Input: After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually.

increased

serum level of calcium and urinary excretion of calcium increased

After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day

skin lesions,

vitamin D3

topical

20 micro g/g

10 g

10 g/day


Input: Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD.

cause

LABD

Vancomycin

Vancomycin


Input: Vision declined after treatment with methylprednisolone, after which fundus examination became consistent with progressive outer retinal necrosis.

after

Vision declined

methylprednisolone

methylprednisolone


Input: Eight days after the end of interferon treatment, he showed signs of inability to sit still for ten seconds and walked around constantly.

inability

he

he

signs of inability to sit still for ten seconds and walked around constantly

Eight days after the end of interferon treatment

Eight days

interferon


Input: Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy.

during

Drug-induced agranulocytosis

infliximab

infliximab

enteropathic spondyloarthropathy


Input: Aripiprazole-induced hiccups: a case report.

induced

hiccups

Aripiprazole

Aripiprazole


Input: The hepatic enzyme disturbances normalized after discontinuation of pegvisomant.

after

The hepatic enzyme disturbances

pegvisomant

pegvisomant


Input: We present a case of a 58-year-old female patient with Graves' disease who developed AA in the third exposure to methimazole (MMI).

developed

a 58-year-old female patient with Graves' disease

female

Graves' disease

AA

in the third exposure to methimazole (MMI)

methimazole


Input: CONCLUSIONS: This is the second case report that describes gemcitabine-induced radiation recall in rectus abdominus muscles after gemcitabine-based radiation therapy.

induced

radiation recall in rectus abdominus muscles

gemcitabine

gemcitabine


Input: One patient was an 80-year-old woman who was admitted for Staphylococcus aureus knee arthritis after several intraarticular injections of sodium hyaluronate and corticosteroids.

after

an 80-year-old woman

woman

Staphylococcus aureus knee arthritis

sodium hyaluronate and corticosteroids

sodium hyaluronate

corticosteroids

injections

several

sodium hyaluronate

corticosteroids


Input: Association of zomepirac administration with renal cortical necrosis is not known to have been previously demonstrated.

Association

renal cortical necrosis

zomepirac

zomepirac


Input: Vasomotor reactions after gold sodium thiomalate are well recognized.

after

Vasomotor reactions

gold sodium thiomalate

gold sodium thiomalate


Input: Moxifloxacin-acetaminophen-warfarin interaction during bacille Calmette-Guerin treatment for bladder cancer.

during

Moxifloxacin-acetaminophen-warfarin interaction

bacille Calmette-Guerin treatment

Moxifloxacin

acetaminophen

warfarin

bacille Calmette-Guerin

bladder cancer

warfarin

acetaminophen

Moxifloxacin

bacille Calmette-Guerin


Input: In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.

secondary

four patients

four

thrombosis occurred

severe hepatic veno-occlusive disease (HVOD)

intensive chemotherapy containing busulfan

2-45 days after

busulfan


Input: An adolescent male developed acute pancreatitis and pseudocyst of the pancreas 16 weeks after cessation of intramuscular L-asparaginase.

after

An adolescent male

adolescent

male

acute pancreatitis and pseudocyst of the pancreas

cessation of intramuscular L-asparaginase

L-asparaginase

intramuscular

16 weeks


Input: A CFTR potentiator in patients with cystic fibrosis and the G551D mutation.

in

patients with cystic fibrosis and the G551D mutation

G551D mutation

CFTR potentiator

cystic fibrosis

CFTR potentiator


Input: Quinapril is an angiotensin-converting enzyme inhibitor (ACE-inhibitor) and overdose can lead to prolonged hypotension and, less frequently, transient renal impairment.

can lead to

prolonged hypotension and, less frequently, transient renal impairment

Quinapril

Quinapril

overdose


Input: We describe a renal transplant recipient maintained on cyclosporine and prednisone developing Nocardia Asteroides brain abscess.

developing

a renal transplant recipient

Nocardia Asteroides brain abscess

maintained on cyclosporine and prednisone

cyclosporine

prednisone

renal transplant recipient

prednisone

cyclosporine


Input: After an extensive review of the literature, we believe that this is the first communication of the successful use of amiodarone to control hyperthyroidism in a patient with PTU-induced fulminant hepatitis.

control

a patient with PTU-induced fulminant hepatitis

PTU-induced fulminant hepatitis

amiodarone

hyperthyroidism

amiodarone


Input: After identification of the index patient, additional inquiry revealed that the patient's mother was hospitalized previously for overwhelming sepsis associated with metamizole use.

associated

the patient's mother

overwhelming sepsis

metamizole

metamizole


Input: We report here on a heretofore undescribed respiratory syncytial virus (RSV) infection in a patient with a long-standing history of refractory CLL that was treated with fludarabine phosphate.

treated

a patient with a long-standing history of refractory CLL

respiratory syncytial virus (RSV) infection

fludarabine phosphate

fludarabine phosphate

refractory CLL


Input: A 77-year-old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma.

receiving

A 77-year-old woman with no history of epilepsy

woman

no history of epilepsy

a probable nonconvulsive status epilepticus

continuous intravenous morphine

morphine

intravenous

continuous

back pain relating to vertebral metastasis of a malignant lymphoma


Input: Oral corticosteroids (OCS) may be associated with systemic adverse events (AEs), which can be reduced by replacing OCS with inhaled corticosteroids (ICS).

associated

systemic adverse events (AEs)

Oral corticosteroids (OCS)

corticosteroids

Oral


Input: Development of Peyronie's disease during long-term colchicine treatment.

during

Peyronie's disease

long-term colchicine treatment

colchicine

long-term


Input: The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.

reverse

DPD-deficient patients with severe acute 5-FU reactions

DPD-deficient

thymidine

5-FU-induced neurologic symptoms such as encephalopathy and coma

severe acute 5-FU reactions

thymidine


Input: Adverse reaction in a patient with aspirin-induced asthma treated with zafirlukast.

induced

a patient

asthma

aspirin

aspirin

zafirlukast

zafirlukast

aspirin


Input: The nephrotic syndrome developed in a patient receiving therapy with gold for rheumatoid arthritis.

developed

a patient

nephrotic syndrome

therapy with gold

rheumatoid arthritis

gold


Input: This observation adds another dimension to the previously reported renal complications of nonsteroidal anti-inflammatory agents, especially zomepirac.

reported

renal complications

nonsteroidal anti-inflammatory agents, especially zomepirac

nonsteroidal anti-inflammatory

zomepirac


Input: Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole.

resolved

Clinical, spectroscopic, and imaging abnormalities

metronidazole

metronidazole


Input: In two other patients (one after OLTX and one with Crohn's disease), a raltegravir-based HIV therapy was started while patients received 1 or 2 mg of tacrolimus twice daily.

received

two other patients (one after OLTX and one with Crohn's disease)

two

raltegravir

1 or 2 mg of tacrolimus twice daily.

HIV

Crohn's disease

OLTX

raltegravir

tacrolimus

1 or 2 mg

twice daily

raltegravir

tacrolimus


Input: Reversible cardiomyopathy caused by administration of interferon alpha.

caused by

Reversible cardiomyopathy

administration of interferon alpha

interferon alpha


Input: Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought.

associated

granulomatous anterior uveitis

Metipranolol

Metipranolol


Input: There was an increase in serious adverse events with bleeding in the tifacogin group in both cohorts (6.5% tifacogin and 4.8% placebo for high INR; 6.0% tifacogin and 3.3% placebo for low INR).

adverse events

bleeding

tifacogin

tifacogin

high INR

low INR


Input: We also describe a case of timolol-induced ocular pemphigoid.

induced

a case

ocular pemphigoid

timolol

timolol


Input: A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching.

taking

A 70-year-old man

man

dyspnea

an antihistaminic agent (homochlorcyclizine hydrochloride)

itching

homochlorcyclizine hydrochloride


Input: Methadone withdrawal when starting an antiretroviral regimen including nevirapine.

starting

Methadone withdrawal

an antiretroviral regimen including nevirapine

nevirapine


Input: The oligohidrosis caused by zonisamide was reversible in that the patient regained the ability to sweat within 2 weeks of the cessation of drug administration.

of the

the patient

regained the ability to sweat within 2 weeks

zonisamide

cessation of drug administration

zonisamide

cessation

within 2 weeks


Input: Radiation recall related to gemcitabine has been reported in lung and breast cancer.

related

Radiation recall

gemcitabine

lung and breast cancer

gemcitabine


Input: It carries a well-known risk of neutropenia and agranulocytosis, which necessitates the immediate discontinuation of clozapine.

risk

neutropenia and agranulocytosis

clozapine

clozapine


Input: Vicriviroc (SCH 417690), a CCR5 receptor antagonist, is currently under investigation for the treatment of human immunodeficiency virus infection.

treatment

Vicriviroc (SCH 417690), a CCR5 receptor antagonist

human immunodeficiency virus infection

Vicriviroc


Input: Children receiving zonisamide should be monitored for oligohidrosis and the development of neurological symptoms associated with an elevation of body temperature.

monitored

Children

Children

oligohidrosis

development of neurological symptoms associated

zonisamide

zonisamide


Input: This concerns 2 male patients who experienced incontinence while taking venlafaxine.

experienced

2 male patients

male

incontinence

venlafaxine

venlafaxine


Input: Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.

after

Polyarthritis, hepatitis and anti-native DNA antibodies

ethambutol and rifampicin

ethambutol

rifampicin

ethambutol

rifampicin


Input: We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.

developed

HIV-infected woman

woman

mild leukopenia

followed by skin and hepatic toxicity associated with a more severe leukopenia

nevirapine

nevirapine

HIV


Input: OBJECTIVE: To report a case of rapidly occurring hyperglycemia that occurred in a geriatric patient 3 days after treatment with olanzapine.

occurring

a geriatric patient

geriatric

hyperglycemia

olanzapine

olanzapine

3 days


Input: Tifacogin administration was associated with an increase in risk of bleeding, irrespective of baseline INR.

associated

an increase in risk of bleeding

Tifacogin

Tifacogin


Input: Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.

developed

two epileptic patients

two

Gynecomastia

some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered

oral

fluoresone

phenobarbital

phenytoin

750 mg

daily

epileptic

some months after

fluoresone

phenobarbital

phenytoin


Input: The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.

toxicity

hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia

combined lithium and haloperidol

lithium

haloperidol

lithium

haloperidol


Input: Occasionally, despite good therapeutic response, clozapine must be stopped due to dangerous side effects such as agranulocytosis.

due to

dangerous side effects such as agranulocytosis

clozapine

clozapine


Input: Three cases of pseudocyst of the pancreas in two women and one man have previously been reported with the use of intravenous L-asparaginase.

reported

two women and one man

two

one

women

man

pseudocyst of the pancreas

intravenous L-asparaginase

L-asparaginase

intravenous


Input: We report a case of Ritalin-associated cataract and glaucoma.

associated

cataract and glaucoma

Ritalin

Ritalin


Input: We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.

developed

severe renal tubular dysfunction

resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria

short-term therapy with Amikacin

Amikacin

short-term


Input: Cardiac toxicity related to BCNU has not been described well.

related

Cardiac toxicity

BCNU

BCNU


Input: Aprepitant is a neurokinin(1) receptor antagonist that enhances prevention of chemotherapy-induced nausea and vomiting when added to conventional therapy with a corticosteroid and a 5-hydroxytryptamine(3) (5-HT(3)) antagonist.

enhances

prevention of chemotherapy-induced nausea and vomiting

Aprepitant

added to conventional therapy with a corticosteroid and a 5-hydroxytryptamine(3) (5-HT(3)) antagonist

Aprepitant

corticosteroid

5-hydroxytryptamine(3) (5-HT(3)) antagonist

Aprepitant

corticosteroid

5-hydroxytryptamine(3) (5-HT(3)) antagonist


Input: Thus, tacrolimus-induced HUS is a rare cause of ARF in nephrotic syndrome.

induced

HUS

tacrolimus

tacrolimus

nephrotic syndrome


Input: Clinicians should be vigilant when monitoring for cardiotoxicity in patients receiving pentamidine throughout the duration of therapy.

receiving

patients

cardiotoxicity

pentamidine

pentamidine


Input: The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.

induced

The present case

hypercalcemia

vitamin D3 ointment and thiazide simultaneously

vitamin D3

thiazide

ointment

vitamin D3

thiazide


Input: CONCLUSION: Significant weight loss is a potential adverse event in patients with rheumatoid arthritis treated with leflunomide.

potential adverse event

Significant weight loss

leflunomide

leflunomide

rheumatoid arthritis


Input: We have described a man with classic rheumatoid arthritis who had membranous nephropathy associated with nephrotic syndrome not related to gold or penicillamine therapy.

not related

a man with classic rheumatoid arthritis

man

membranous nephropathy associated with nephrotic syndrome

gold or penicillamine therapy

gold

penicillamine

classic rheumatoid arthritis


Input: Pharmacokinetics of etravirine in HIV-infected patients concomitantly treated with rifampin for tuberculosis.

for

HIV-infected patients

Pharmacokinetics of etravirine

concomitantly treated with rifampin

etravirine

rifampin

HIV

tuberculosis

etravirine

rifampin


Input: We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis.

had

destroyed the gastric mucosal barrier or thrombocytopenia

hemorrhagic gastritis

excessive dose of AZ

excessive dose

AZ


Input: Acyclovir-induced neurotoxicity: concentration-side effect relationship in acyclovir overdose.

induced

neurotoxicity

Acyclovir

Acyclovir

overdose


Input: Psoriasis-like skin reaction in a patient with rheumatoid arthritis after sulphasalazine therapy.

after

a patient with rheumatoid arthritis

Psoriasis-like skin reaction

sulphasalazine therapy

rheumatoid arthritis

sulphasalazine


Input: We describe the clinical course of 2 patients with Crohn's disease (CD) in whom lymphoma was diagnosed after treatment with infliximab.

diagnosed

2 patients with Crohn's disease (CD)

lymphoma

treatment with infliximab

Crohn's disease

infliximab


Input: Valproic acid is commonly and effectively used in the treatment of idiopathic generalized epilepsies, including juvenile absence epilepsy.

used

Valproic acid

Valproic acid

idiopathic generalized epilepsies

juvenile absence epilepsy


Input: We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia.

manifesting

a case

left arm weakness and aphasia

intrathecal methotrexate neurotoxicity

methotrexate


Input: According to the Drug Interaction Probability Scale, a causal relationship between the warfarin-cloxacillin interaction and increased INR value was rated "probable".

relationship

increased INR value

warfarin

cloxacillin

warfarin

cloxacillin

warfarin

cloxacillin


Input: We present the cases of two female patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) who developed inflammatory musculoskeletal manifestations, following IFN-beta therapy.

developed

two female patients diagnosed with relapsing-remitting multiple sclerosis (RRMS)

two

female

inflammatory musculoskeletal manifestations

IFN-beta

IFN-beta

relapsing-remitting multiple sclerosis


Input: Dystonia associated with carbamazepine administration: experience in brain-damaged children.

associated with

brain-damaged children

brain-damaged

children

Dystonia

carbamazepine administration

carbamazepine


Input: In all, 51 patients had a gastrointestinal event; the event rate was 1.1% with omeprazole and 2.9% with placebo at 180 days (hazard ratio with omeprazole, 0.34, 95% confidence interval [CI], 0.18 to 0.63; P<0.001).

had

51 patients

gastrointestinal event

1.1% with omeprazole and 2.9% with placebo

omeprazole

placebo

180 days


Input: CONCLUSION: We report a case of the use of pamidronate for significant hypercalcemia secondary to acute vitamin D poisoning.

for

a case

pamidronate

hypercalcemia

vitamin D

pamidronate


Input: Clopidogrel with or without omeprazole in coronary artery disease.

in

Clopidogrel with or without omeprazole

coronary artery disease

Clopidogrel

omeprazole

Clopidogrel

Clopidogrel

omeprazole


Input: The cases are important in documenting that drug-induced dystonias do occur in patients with dementia, that risperidone appears to have contributed to dystonia among elderly patients, and that the categorization of dystonic reactions needs further clarification.

contributed

patients with dementia

elderly patients

dementia

elderly

dystonia

risperidone

risperidone


Input: In addition, there is a report on prolonged ECT seizure related to ciprofloxacin, which has an epileptogenic property with a similar action to beta-lactam antibiotics.

related

prolonged ECT seizure

ciprofloxacin

ciprofloxacin


Input: After abstinence from oolong tea his delirium resolved.

After

oolong tea

delirium


Input: Anaphylaxis to intrathecal diamorphine.

to

Anaphylaxis

intrathecal diamorphine

intrathecal

diamorphine


Input: This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.

result

increased serum lithium concentrations

acyclovir

acyclovir

10 mg/kg


Input: After approximately two weeks of sertraline treatment he noted an intense itching sensation in his scalp after eating a piece of chocolate cake.

noted

intense itching sensation in his scalp

two weeks of sertraline

sertraline

chocolate

two weeks

chocolate

sertraline


Input: Pigmentary aberrations are well known side effects of cytostatic chemotherapeutic agents.

side effects

Pigmentary aberrations

cytostatic chemotherapeutic agents

cytostatic chemotherapeutic agents


Input: CONCLUSION: Atovaquone should be added to the list of agents causing vortex keratopathy involving the corneal epithelium.

causing

vortex keratopathy involving the corneal epithelium

Atovaquone

Atovaquone


Input: A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.

occurred

generalized tonic-clonic seizure

a few minutes after injection of the morphine antagonist naloxone

a few minutes

injection

naloxone


Input: CONCLUSION: Squamous metaplasia in these cases appears to be a consequence of progestin therapy.

consequence

these cases

Squamous metaplasia

progestin therapy

progestin


Input: This association should be considered in the period after vasopressin-treated gastrointestinal hemorrhage.

after

gastrointestinal hemorrhage

vasopressin

vasopressin

gastrointestinal hemorrhage


Input: The gynecomastia regressed when the theophylline was discontinued.

discontinued.

gynecomastia

theophylline

theophylline


Input: Renal hypophosphatemia in this patient was caused by the erroneous intake of 1 g doxycycline.

caused

this patient

Renal hypophosphatemia

the erroneous intake of 1 g doxycycline.

doxycycline

1 g


Input: Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.

developed

the patient

a progressive visual loss and loss of consciousness

led to death

MTX treatment

subsequent Ara-C treatment

within 3 weeks.

meningeal tumor

MTX

Ara-C

3 weeks.

MTX

Ara-C


Input: After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.

developed

a nine-year-old boy

nine-year-old

boy

polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor

seven months' continuous treatment

with rifampicin and ethambutol

rifampicin

ethambutol

tuberculosis

seven months

ethambutol

rifampicin


Input: A few recent individual case reports have suggested that a myasthenic syndrome may be associated with statin treatment, but this association is not well described.

associated

A few recent individual case

myasthenic syndrome

statin treatment

statin


Input: Topical imiquimod and tumor necrosis factor (TNF)-alpha inhibitors have gained wide acceptance as safe and effective treatments for non-melanoma skin cancer (NMSC) and moderate to severe psoriasis, respectively.

treatments

Topical imiquimod

non-melanoma skin cancer (NMSC)

Topical

imiquimod


Input: Focal renal cortical necrosis associated with zomepirac.

associated

Focal renal cortical necrosis

zomepirac

zomepirac


Input: We experienced 2 cases of mequitazine-induced photosensitivity reaction in patients who took mequitazine for their dermatologic problems.

induced

patients

photosensitivity reaction

mequitazine

dermatologic problems

mequitazine


Input: Carboplatin was substituted for cisplatin, and there were no further episodes of SIADH.

substituted

Carboplatin was substituted for cisplatin

SIADH

cisplatin


Input: Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.

induced

glaucoma

intravitreal injection of triamcinolone acetonide

steroid

triamcinolone acetonide

intravitreal injection


Input: CD20-negative T-cell-rich B-cell lymphoma as a progression of a nodular lymphocyte-predominant Hodgkin's lymphoma treated with rituximab: a molecular analysis using laser capture microdissection.

treated

CD20-negative T-cell-rich B-cell lymphoma

rituximab

rituximab

nodular lymphocyte-predominant Hodgkin's lymphoma


Input: We report the case of an adult patient with acute lymphoblastic leukemia who presented with repeated transient ischemic attacks followed by a seizure during consolidation treatment with L-asparaginase.

presented

an adult patient with acute lymphoblastic leukemia

adult

repeated transient ischemic attacks followed by a seizure

consolidation treatment with L-asparaginase

acute lymphoblastic leukemia

L-asparaginase


Input: Gemcitabine-related radiation recall in a patient with pancreatic cancer.

related

a patient with pancreatic cancer

radiation recall

Gemcitabine

Gemcitabine

pancreatic cancer


Input: After development of the tics in 2, CBZ was continued at the same or higher dose, and the tics abated and then ceased spontaneously < or = 6 months.

development

tics

CBZ

CBZ

the same or higher dose


Input: Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.

occurring

a patient

severe neutropenia

olanzapine

olanzapine


Input: We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.

developed

3 AS patients

CD

etanercept for active AS

active AS

AS

etanercept


Input: It is concluded that the aforementioned pathological manifestations were due to chemotherapy and included a pulmonary adverse reaction, a feature never previously associated with oxaliplatinum and 5-fluorouracil regimens.

associated

a pulmonary adverse reaction

oxaliplatinum and 5-fluorouracil regimens

oxaliplatinum

oxaliplatinum


Input: A case of colchicine-induced rhabdomyolysis is reported.

induced

rhabdomyolysis

colchicine

colchicine


Input: Because of a recurrence of paroxysmal atrial fibrillation, the dose of the drug was increased to 1.4 g/day; 24 hours later AVT with syncope developed but responded promptly to atropine.

developed

paroxysmal atrial fibrillation

paroxysmal atrial fibrillation

AVT with syncope

the dose of the drug was increased to 1.4 g/day

24 hours

1.4 g/day

the drug


Input: Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration.

after

Three male patients aged 78-83 years

Three

male

78-83 years

severe hepatotoxic reactions

CPA

CPA


Input: Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559).

related

Exacerbations of the heart failure

antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559)

actinomycin-D

mithramycin


Input: Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis.

after

a patient with rheumatoid arthritis

Diffuse alveolar hemorrhage

leflunomide

rheumatoid arthritis

leflunomide


Input: We report a case of a 64-year-old man with secondary adrenocortical insufficiency who has been on a chronic transdermal fentanyl treatment because of sciatic pain syndrome.

with

a 64-year-old man

man

secondary adrenocortical insufficiency

a chronic transdermal fentanyl treatment

fentanyl

sciatic pain syndrome

transdermal

chronic


Input: A 52-year-old, white female developed low-grade fever, cough, and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis.

developed

A 52-year-old

white female

white

female

low-grade fever, cough, and dyspnea

sodium aurothiomalate

8 weeks

sodium aurothiomalate

rheumatoid arthritis


Input: In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.

developed

In both cases

both

high fever, skin rash, liver dysfunction and atypical lymphocytosis

SASP

SASP


Input: OBJECTIVE: To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax.

toxicity

high-grade chloroquine-resistant Plasmodium vivax

high-grade chloroquine-resistant Plasmodium vivax

severe chloroquine toxicity

chloroquine

chloroquine


Input: RESULTS: All cases developed corneal endothelial deposits after previous use of rifabutin.

developed

All cases

corneal endothelial deposits

rifabutin

rifabutin


Input: Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.

developed

Two infants

Two

infants

hyperkalemia

shortly after cessation of prolonged ACTH therapy

infantile spasms

shortly after

cessation

ACTH


Input: In this case, CIPS was considered to be probably associated with cyclosporine according to the Naranjo probability scale.

associated

CIPS

cyclosporine

cyclosporine


Input: Acute syphilitic posterior placoid chorioretinitis following intravitreal triamcinolone acetonide injection.

following

Acute syphilitic posterior placoid chorioretinitis

intravitreal triamcinolone acetonide injection

intravitreal

injection

triamcinolone acetonide


Input: Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.

can

Delayed pseudocyst of the pancreas

intramuscular L-asparaginase

L-asparaginase

intramuscular


Input: I report a 35-year-old woman with occult coronary artery disease who experienced cardiac arrest within minutes after receiving a first-time dose of subcutaneous sumatriptan for migraine.

experienced

a 35-year-old woman with occult coronary artery disease

woman

occult coronary artery disease

cardiac arrest

within minutes after receiving a first-time dose of subcutaneous sumatriptan

sumatriptan

migraine

subcutaneous

within minutes

a first-time dose


Input: Epoprostenol (prostacyclin) is currently approved for treatment of primary pulmonary hypertension; however, it is being evaluated in other forms of pulmonary hypertension, particularly scleroderma.

treatment

Epoprostenol (prostacyclin)

Epoprostenol

prostacyclin

primary pulmonary hypertension


Input: OBJECTIVE: To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis.

treated

man

man

fatal case of toxic epidermal necrolysis

oral ofloxacin

oral

ofloxacin

epididymitis


Input: Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.

due

Massive pulmonary embolism

heparin

heparin


Input: Value of high-dose cytarabine during interval therapy of a Berlin-Frankfurt-Munster-based protocol in increased-risk children with acute lymphoblastic leukemia and lymphoblastic lymphoma: results of the European Organization for Research and Treatment of Cancer 58881 randomized phase III trial.

Value

increased-risk children with acute lymphoblastic leukemia and lymphoblastic lymphoma

children

high-dose cytarabine during interval therapy of a Berlin-Frankfurt-Munster-based protocol

acute lymphoblastic leukemia

lymphoblastic lymphoma

cytarabine

high-dose


Input: We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously.

associated

a case

fulminant hepatic failure

didanosine

didanosine


Input: An objective causal assessment suggests that rhabdomyolysis, renal failure, and possibly hepatotoxicity were probably related to an amiodarone-simvastatin interaction.

related

rhabdomyolysis, renal failure, and possibly hepatotoxicity

an amiodarone-simvastatin interaction

amiodarone

simvastatin

amiodarone

simvastatin


Input: Nail staining from hydroquinone cream.

from

Nail staining

hydroquinone cream

hydroquinone

cream


Input: The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.

development

an epilepsy patient

an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma

diphenylhydantoin (DILANTIN) therapy for 20 years

epilepsy

diphenylhydantoin

for 20 years


Input: Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.

characterized

GI upset, dizziness, and mild sedation

Ibuprofen overdose

Ibuprofen

overdose


Input: His PD medications (pramipexole, entacapone, and immediate-release levodopa/carbidopa 100 mg/25 mg, 1.5 tablets 4 times daily) were administered via nasogastric tube.

administered

His PD

His

pramipexole, entacapone, and immediate-release levodopa/carbidopa 100 mg/25 mg, 1.5 tablets 4 times daily

via nasogastric tube

PD

pramipexole

entacapone

levodopa

carbidopa

100 mg/25

mg/25 mg

1.5 tablets

4 times daily

nasogastric tube

pramipexole

entacapone

levodopa

carbidopa


Input: CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.

caused

adverse effects (eg, dizziness, falls) and mimicked coronary artery disease

propafenone

citalopram

propafenone

citalopram

propafenone

citalopram


Input: We report the case of a young healthy woman who presented an early overanticoagulation when receiving acenocoumarol for a first thromboembolic episode.

presented

a young healthy woman

young

woman

early overanticoagulation

acenocoumarol

thromboembolic

acenocoumarol


Input: A patient with acute changes suggesting acute hepatitis after parenteral amiodarone administration is described.

after

A patient

acute changes suggesting acute hepatitis

parenteral amiodarone administration

amiodarone


Input: Subsequently, he developed hyperglycemia (fasting blood glucose 138 mg/dL) that resolved when olanzapine was stopped and recurred (fasting blood glucose 150 mg/dL) after 2 days of rechallenge with olanzapine 2.5 mg twice daily.

resolved

olanzapine was stopped

hyperglycemia (fasting blood glucose 138 mg/dL)

olanzapine


Input: Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.

on

HIV-infected patients

Fulminant hepatitis with severe lactate acidosis

didanosine

HIV

didanosine


Input: Persisent ocular hypertension following intravitreal ranibizumab.

following

Persisent ocular hypertension

intravitreal ranibizumab

ranibizumab


Input: STUDY DESIGN: Case report of a 31-year-old woman who presented with toxic myelopathy due to intrathecal administration of doxorubicin.

due

a 31-year-old woman

woman

toxic myelopathy

intrathecal administration of doxorubicin.

doxorubicin

intrathecal


Input: The patient had a background of obsessive compulsive disorder treated with paroxetine.

treated

The patient had a background of obsessive compulsive disorder

paroxetine

obsessive compulsive disorder

paroxetine


Input: Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels.

cause

patients with defective calcium-activated K+ channels

defective calcium-activated K+ channels

rhabdomyolysis

Clozapine

Clozapine


Input: CONCLUSIONS: We report the first case of gemcitabine-induced LABD.

induced

LABD

gemcitabine

gemcitabine


Input: Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities.

induced

lung disease

Nitrofurantoin

Nitrofurantoin


Input: Trazodone-induced transient hypomanic symptoms and their management.

induced

transient hypomanic symptoms

Trazodone

Trazodone


Input: Acute aluminum toxicity after continuous intravesical alum irrigation for hemorrhagic cystitis.

after

Acute aluminum toxicity

continuous intravesical alum irrigation

hemorrhagic cystitis

intravesical

irrigation

alum


Input: Amphotericin B-induced cutaneous leucocytoclastic vasculitis: case report.

induced

cutaneous leucocytoclastic vasculitis

Amphotericin B

Amphotericin B


Input: When measured, the serum lithium level had increased 4-fold during acyclovir therapy.

during

serum lithium level had increased 4-fold

acyclovir

acyclovir

lithium

lithium

acyclovir


Input: In this paper it is reported an evidence of pharmacokinetic interaction between clarithromycin and sirolimus in a kidney transplanted woman, suffering from pulmonary infection sustained by a bacterial pathogen, in particular Hemophilus Influenzae.

between

a kidney transplanted woman, suffering from pulmonary infection sustained by a bacterial pathogen, in particular Hemophilus Influenzae

kidney transplanted

woman

pharmacokinetic interaction

clarithromycin and sirolimus

clarithromycin

sirolimus

pulmonary infection

clarithromycin

sirolimus


Input: A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented.

after

A 25-year-old man with a history of mid-borderline (BB) Hansen's disease

man

mid-borderline (BB) Hansen's disease

a reversal reaction

dapsone and rifampin therapy

dapsone

rifampin

dapsone

rifampin


Input: In all cases, drugs in addition to quetiapine were detected, but in cases #1 and #2, the cause of death was considered to be a quetiapine overdose and the other drugs were not considered to be contributory.

cause

cases #1 and #2

death

quetiapine overdose

quetiapine

quetiapine

overdose


Input: Similar to antiarrhythmic drugs aggravating particular arrhythmias, antiepileptic drugs can paradoxically induce new seizure types or exacerbate existing ones.

induce

new seizure types or exacerbate existing ones

antiepileptic drugs

antiarrhythmic drugs

antiepileptic drugs


Input: We report here a rare case of ritodrine-hydrochloride-induced rhabdomyolysis in a pregnant patient with myotonic dystrophy.

induced

pregnant patient with myotonic dystrophy.

pregnant

rhabdomyolysis

ritodrine-hydrochloride

ritodrine-hydrochloride

myotonic dystrophy


Input: OBJECTIVE: To report the finding of squamous metaplasia within endometrial glands occurring as a result of progestin therapy of hyperplasia.

as a result of

squamous metaplasia within endometrial glands

progestin therapy

hyperplasia

progestin


Input: IMPLICATIONS FOR NURSING PRACTICE: Nurses must understand the pharmacology, mechanism of action, clinical presentation, potentially lethal risks, and traumatic psychosocial stresses experienced by DPD-deficient patients with cancer receiving 5-FU therapy in order to develop timely interventions and alternative plans of care.

receiving

DPD-deficient patients with cancer

DPD-deficient

5-FU therapy

cancer


Input: Methotrexate is an effective but potentially toxic treatment for psoriasis.

treatment

Methotrexate

Methotrexate

psoriasis


Input: Typical symptoms of active CD occurred 11, 12, and 26 months after start of etanercept therapy, respectively.

occurred

Typical symptoms of active CD

etanercept therapy

etanercept

11, 12, and 26 months after start


Input: This progressed to tracheal compression with stridor after he had taken some aspirin for relief of the neck pain.

progressed

he

he

tracheal compression with stridor

aspirin

aspirin

neck pain


Input: OBJECTIVE: To report a case of toxin-positive Clostridium difficile-induced colitis (CDIC) after use of clindamycin phosphate vaginal cream.

after

toxin-positive Clostridium difficile-induced colitis

clindamycin phosphate vaginal cream

toxin

clindamycin phosphate

vaginal cream


Input: Severe vancomycin-induced anaphylactic reaction.

induced

anaphylactic reaction

vancomycin

vancomycin


Input: We report the case of a 74-year-old female patient who received the antide-pressant amitriptyline because of a major depression.

received

a 74-year-old female patient

a major depression

female

antide-pressant amitriptyline

major depression

amitriptyline


Input: Rhabdomyolysis has been recognized as a complication of tocolytic therapy with ritodrine hydrochloride.

complication

Rhabdomyolysis

ritodrine hydrochloride

ritodrine hydrochloride.


Input: Voriconazole (VRC) has not previously been reported to cause angio-oedema.

cause

angio-oedema

Voriconazole (VRC)

Voriconazole


Input: CONCLUSION: Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state.

cause

malignant transformation of endometriosis through atypical endometriosis

Tamoxifen

Tamoxifen


Input: One patient had an episode of prostatitis, which was treated with levofloxacin immediately prior to tolterodine initiation.

treated

One patient

One

levofloxacin

tolterodine

prostatitis

levofloxacin

tolterodine

levofloxacin

tolterodine


Input: The first patient developed a monoarthritis 2 weeks after initiation of IFN-beta, which persisted during the 14 months of therapy and resolved with discontinuation of the medication.

initiation

The first patient

monoarthritis

IFN-beta

IFN-beta


Input: The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.

after

refractory akathisia

interferon-alpha treatment

interferon-alpha


Input: Rosaceiform eruption induced by erlotinib.

induced

Rosaceiform eruption

erlotinib.

erlotinib


Input: The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.

induced

hypotension

oral-verapamil

in the presence of concomitant beta-adrenergic blockade

verapamil

oral

oral


Input: Until additional data are available, if intravenous acyclovir is administered concurrently with lithium, we recommend closely monitoring patients for signs of lithium toxicity and measuring serum lithium levels every second or third day.

signs

lithium toxicity

intravenous acyclovir is administered concurrently with lithium

acyclovir

lithium

intravenous

lithium

acyclovir


Input: Disappointingly, with the dose schedule used in this protocol, HD Ara-C added to HD MTX, although well tolerated, failed to further decrease the incidence of CNS relapse or to improve the overall DFS.

failed

further decrease the incidence of CNS relapse or to improve the overall DFS

HD Ara-C

HD MTX

HD Ara-C

HD MTX

HD Ara-C

HD MTX


Input: Theophylline intoxication following viloxazine induced decrease in clearance.

following

Theophylline intoxication

viloxazine

viloxazine

Theophylline

viloxazine

Theophylline


Input: Cercarial encystment at concentrations of 25000 microg/l or higher was significantly impaired by all test metals; however, at lower concentrations only zinc demonstrated toxicity.

demonstrated

toxicity

lower concentrations

zinc

lower concentrations

zinc


Input: PURPOSE: We report an unusual paradoxical effect of brimonidine.

of

unusual paradoxical effect

brimonidine

brimonidine


Input: Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism.

after

a child homozygous for MTHFR C677T polymorphism

child

homozygous for MTHFR C677T polymorphism

Renal failure

high-dose methotrexate

high-dose

methotrexate


Input: Although his renal function recovered completely with high-dose leucovorin, hemodialysis, charcoal hemoperfusion, and carboxypeptidase G2, we present this case to emphasize that signs of renal toxicity may be present as early as 2 hours after the completion of a 4-hour MTX infusion, and to suggest that monitoring for MTX toxicity should perhaps begin within a few hours after the completion of 4-hour MTX infusion.

after

renal toxicity

2 hours after the completion of a 4-hour MTX infusion

MTX

infusion

2 hours


Input: Ten to 15% of patients treated with ifosfamide develop an encephalopathy.

develop

Ten to 15% of patients

Ten to 15%

encephalopathy.

ifosfamide

ifosfamide


Input: METHODS: We queried 35 rheumatologists at the Robert Breck Brigham Arthritis Center to determine if weight loss had occurred as an adverse event in patients treated with leflunomide between November 1998 and January 2000.

occurred

patients

weight loss

leflunomide

leflunomide


Input: This is the first report of a catatonic syndrome occurring in a patient receiving disulfiram treatment.

occurring

catatonic syndrome

disulfiram treatment

disulfiram


Input: Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate.

Management

intravenous phosphorus

phosphorus-enriched dialysate

hypophosphatemia

intravenous

dialysate

phosphorus

phosphorus


Input: Two weeks following rechallenge with alendronate sodium resulted in recurrence of his scleritis.

resulted

scleritis

alendronate sodium

Two weeks following

alendronate sodium

Two weeks following


Input: We believe this is the first report of intrathecal diamorphine causing anaphylaxis.

causing

anaphylaxis

intrathecal diamorphine

diamorphine

intrathecal


Input: Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis.

induced

rhabdomyolysis

cerivastatin

cerivastatin


Input: This case report and several others point toward azathioprine as a clinically significant inducer of warfarin resistance.

inducer

warfarin resistance

azathioprine

warfarin

azathioprine


Input: PURPOSE: To report a case of nodular scleritis following alendronate sodium.

following

nodular scleritis

alendronate sodium

alendronate sodium


Input: Most cardiac surgical patients have had previous exposure to heparin for diagnostic or therapeutic interventions and hence have an increased susceptibility to developing heparin-induced thrombocytopenia (HIT) postoperatively.

developing

Most cardiac surgical patients

cardiac surgical

heparin-induced thrombocytopenia (HIT)

heparin

heparin


Input: PURPOSE: We studied a case of vortex keratopathy that was associated with the use of atovaquone.

associated

a case

vortex keratopathy

atovaquone

atovaquone


Input: While on a maximal dose of phenylephrine she developed prominent positive U waves, which disappeared with the cessation of the drug.

developed

she

she

positive U waves

maximal dose of phenylephrine

maximal dose

phenylephrine


Input: RESULTS: Two patients with ocular inflammation of unknown origin developed severe chorioretinitis after IVTA injection.

developed

Two patients with ocular inflammation

ocular inflammation

Two

severe chorioretinitis

IVTA injection

IVTA

injection


Input: Disopyramide was started on admission for supraventricular tachycardia.

started

Disopyramide

supraventricular tachycardia

Disopyramide


Input: A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.

developed

A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods

woman

a spinal cord lesion

zolmitriptan

zolmitriptan

migraine without aura


Input: The skin rash effect was most probably due, in first line, to olanzapine, but the cutaneous skin condition was triggered and aggravated by pravastatin, a 3-hydoxy-3-methylglutaryl-coenzyme A-(HMG-CoA)-reductase inhibitor, and lithium medication.

due,

skin rash effect

cutaneous skin condition

olanzapine,

by pravastatin, a 3-hydoxy-3-methylglutaryl-coenzyme A-(HMG-CoA)-reductase inhibitor, and lithium

olanzapine

pravastatin

lithium

lithium

pravastatin

olanzapine


Input: CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa.

complicate

Anterior ischemic optic neuropathy

interferon alfa

interferon alfa


Input: After 5 weeks of therapy, she stopped taking pantoprazole due to general malaise.

due to

general malaise

taking pantoprazole

After 5 weeks of therapy

5 weeks

pantoprazole


Input: We report the use of pamidronate for acute, severe hypercalcemia secondary to iatrogenic vitamin D poisoning.

for

pamidronate

acute, severe hypercalcemia secondary to iatrogenic vitamin D poisoning

pamidronate


Input: According to the Naranjo probability scale, the relationship of gemcitabine treatment with cutaneous eruption in our patient is possible.

with

our patient

cutaneous eruption

gemcitabine treatment

gemcitabine


Input: Methylene blue was administered to a 58-yr-old woman undergoing a parathyroidectomy under general anesthesia.

administered to

a 58-yr-old woman undergoing a parathyroidectomy under general anesthesia

woman

Methylene blue

Methylene blue


Input: We describe two cases that illustrate the use of lithium in the treatment of veterans with PTSD who complained of serious problems with irritability or angry outbursts.

complained of

veterans with PTSD

serious problems with irritability or angry outbursts

lithium

lithium

PTSD


Input: It is well-recognized that flucloxacillin may occasionally result in fatal hepatic injury.

result

hepatic injury

flucloxacillin

flucloxacillin


Input: Neurologic toxicity associated with hepatic artery infusion HAI of FUdR.

associated with

Neurologic toxicity

hepatic artery infusion HAI of FUdR.

FUdR.

hepatic artery infusion


Input: Hyperkalemia as a late side effect of prolonged adrenocorticotropic hormone therapy for infantile spasms.

of

infantile spasms

infantile

Hyperkalemia

adrenocorticotropic hormone

infantile spasms

adrenocorticotropic hormone


Input: METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.

caused

two cases

two

pseudoporphyria

naproxen and oxaprozin

naproxen

oxaprozin

oxaprozin

naproxen


Input: She was treated with an average weekly warfarin dose of 39 mg (5.5 mg daily) prior to beginning azathioprine therapy.

treated

She

She

average weekly warfarin dose of 39 mg (5.5 mg daily) prior to beginning azathioprine therapy

warfarin

azathioprine

weekly

daily

39 mg

5.5 mg


Input: When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects.

of

side effects

amphotericin B

amphotericin B


Input: Widespread cutaneous vasculitis associated with diltiazem.

associated

cutaneous vasculitis

diltiazem

diltiazem


Input: The following describes a patient on a stable regimen of warfarin who developed severe hypoprothrombinemia and bleeding 4 weeks after starting gemfibrozil.

developed

a patient

hypoprothrombinemia and bleeding

on a stable regimen of warfarin

4 weeks after starting gemfibrozil

warfarin

gemfibrozil

4 weeks


Input: We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin.

developed

a 40-year-old woman

woman

fulminant hepatic failure and aplastic anaemia

a course of oral flucloxacillin

oral

flucloxacillin

a course


Input: This case highlights the possible development of acute coronary syndrome as a side effect of Capecitabine therapy.

development

This case

acute coronary syndrome

Capecitabine

Capecitabine


Input: These results indicate that lithium may cause biochemical hyperparathyroidism.

may

biochemical hyperparathyroidism

lithium

lithium


Input: The relationship between infliximab treatment and lymphoma in Crohn's disease.

between

lymphoma

infliximab

Crohn's disease

infliximab


Input: CONCLUSION: There may be an association between raloxifene and the development of malignant mixed mesodermal tumor.

association

malignant mixed mesodermal tumor

raloxifene

raloxifene


Input: Early recognition of renal toxicity of high-dose methotrexate therapy: a case report.

recognition

renal toxicity

high-dose methotrexate therapy

high-dose

methotrexate


Input: The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoproliferative diseases, but coincidence cannot be excluded.

developing

patients with rheumatoid arthritis

mild immunosuppression

lymphoproliferative diseases

methotrexate

rheumatoid arthritis

methotrexate


Input: We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.

attribute

cytotoxic edema

intrathecal methotrexate

methotrexate


Input: Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed.

causes

hyperhidrosis

facial flushing

Morphine

Morphine


Input: Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors.

associated

Severe aphthous stomatitis

oral calcineurin and mTOR inhibitors

oral

mTOR inhibitors

calcineurin

calcineurin

mTOR inhibitors


Input: A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.

after

A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis

man

ischemic heart disease

chronic atrial fibrillation

chronic renal failure

hypothyroidism

fatigue, myalgia, and leg weakness

treatment with colchicine

colchicine

shortly

gout arthritis


Input: This report describes a case of paradoxical, intravenous valproic acid-induced seizure exacerbation in a child with juvenile absence epilepsy, documented by video-electroencephalography.

induced

a child with juvenile absence epilepsy

child

seizure exacerbation

intravenous valproic acid

valproic acid

intravenous

juvenile absence epilepsy


Input: She was treated with acyclovir and subsequently developed VZV antigen-positive zoster.

developed

She

She

VZV antigen-positive zoster

acyclovir

acyclovir


Input: CONCLUSIONS: In these 3 cases, the unique positive ocular finding was corneal endothelial deposits, which may be related to the use of rifabutin.

related

corneal endothelial deposits

rifabutin

rifabutin


Input: Response of a promethazine-induced coma to flumazenil.

induced

coma

promethazine

promethazine


Input: First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.

during

41 anecdotic cases

neutropenia or agranulocytosis

olanzapine (Zyprexa)

olanzapine


Input: Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.

associated

patients with vitamin B12 deficiency

vitamin B12 deficiency

Neurologic degeneration

nitrous oxide anesthesia

nitrous oxide


Input: Previous therapy with antiarrhythmics had resulted in intolerable adverse effects or no effect on the arrhythmia.

resulted

intolerable adverse effects

antiarrhythmics

arrhythmia

antiarrhythmics


Input: Allergic contact dermatitis to compound tincture of benzoin.

to

Allergic contact dermatitis

compound tincture of benzoin

benzoin


Input: PURPOSE: To determine the cause of spontaneous choroidal hemorrhage in a 67-year-old man after a myocardial infarction and administration of tissue plasminogen activator.

in

67-year-old man after a myocardial infarction

man

spontaneous choroidal hemorrhage

tissue plasminogen activator

myocardial infarction

tissue plasminogen activator


Input: Forty-one days later, she developed severe iatrogenic Cushing's syndrome due to the drug-drug interaction between triamcinolone and her boosted protease inhibitor therapy.

developed

she

she

Forty-one days later

severe iatrogenic Cushing's syndrome

triamcinolone and her boosted protease inhibitor

triamcinolone

protease inhibitor

triamcinolone

protease inhibitor


Input: Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.

taking

five female patients

five

female

Pheripheral edema

omeprazole, lansoprazole, or pantoprazole

omeprazole

lansoprazole

pantoprazole

7-15 days

peptic acid diseases

standard doses.


Input: We report the case of a child with metastatic osteosarcoma, who experienced an anaphylactic/anaphylactoid reaction to methotrexate.

experienced

a child with metastatic osteosarcoma

child

anaphylactic/anaphylactoid reaction

methotrexate

methotrexate


Input: It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus.

involved

lichen nitidus

interferon alpha

interferon alpha


Input: CONCLUSION: Alendronate led to nodular scleritis and rechallenge caused recurrence of scleritis.

led to

nodular scleritis

Alendronate

Alendronate


Input: A massive digitoxin (DGTX) intoxication in a 36-year-old man (35 mg DGTX) was treated by prolonged and repeated i.v.-infusions of Fab fragments of anti-digitalis antibodies (FAB).

treated

A massive digitoxin (DGTX) intoxication in a 36-year-old man (35 mg DGTX)

man

prolonged and repeated i.v.-infusions of Fab fragments of anti-digitalis antibodies (FAB)

massive digitoxin (DGTX) intoxication

i.v.-infusions

anti-digitalis antibodies


Input: Gold-salt therapy may result in damage to proximal tubules that leak renal tubular antigens, which in turn complex with autoantibody and produce an autoimmune membranous nephropathy.

result

damage to proximal tubules

Gold-salt

Gold-salt


Input: Only two case reports of adults with allergic contact dermatitis to this chemical exist in the literature, and we describe three more cases of children with recalcitrant atopic dermatitis found to have potential allergic contact dermatitis to bisabolol- a component of the Aquaphor emollient they were using to treat their atopic dermatitis.

have

three more cases of children with recalcitrant atopic dermatitis

three

children

potential allergic contact dermatitis

bisabolol- a component of the Aquaphor emollient

recalcitrant atopic dermatitis

bisabolol


Input: Recently, CD20-negative tumors have been described after Rituximab therapy.

after

CD20-negative tumors

Rituximab

Rituximab


Input: A 48-year-old woman who was treated for thyrotoxicosis with methimazole developed agranulocytosis.

developed

A 48-year-old woman

woman

agranulocytosis

methimazole

thyrotoxicosis

methimazole


Input: Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.

induced

encephalopathy

ifosfamide

ifosfamide


Input: We report a case of a women in whom a malignant mixed mesodermal tumor was diagnosed while she was taking raloxifene, which is also a selective estrogen receptor modulator.

diagnosed

a women

women

a malignant mixed mesodermal tumor

while she was taking raloxifene

raloxifene


Input: Interactions between warfarin and cloxacillin can result in serious adverse reactions.

result

serious adverse reactions

Interactions between warfarin and cloxacillin

warfarin

cloxacillin

warfarin

cloxacillin


Input: However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.

associated

three cases

three

Stevens-Johnson syndrome or toxic epidermal necrolysis

ofloxacin

ofloxacin


Input: Acetazolamide may have accelerated the development of osteomalacia by several mechanisms, including increased renal calcium excretion.

accelerated

osteomalacia

Acetazolamide

Acetazolamide


Input: In conclusion, RSDS is a relevant osteoarticular complication in patients receiving either anticalcineurinic drug (CyA or tacrolimus), even under monotherapy or with a low steroid dose.

osteoarticular complication

RSDS

anticalcineurinic drug (CyA or tacrolimus)

CyA

tacrolimus


Input: There have been several reported cases of omeprazole-induced AIN.

induced

AIN

omeprazole

omeprazole


Input: This interaction may be overlooked by clinicians, which may result in a serious bleeding risk for patients on warfarin.

result in

patients

serious bleeding risk

warfarin

warfarin


Input: Adriamycin-induced cardiomyopathy aggravated by cis-platinum nephrotoxicity requiring dialysis.

induced

cardiomyopathy

Adriamycin

Adriamycin


Input: An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome.

suffering

An 11-year-old boy

boy

respiratory distress syndrome

relatively high dose of methotrimeprazine meleate (Levemepromazine)

relatively high dose

methotrimeprazine meleate


Input: An adult male presented with central blindness after ingesting methanol.

presented

An adult male

adult

male

central blindness

ingesting methanol

ingesting

methanol


Input: All developed mucocutaneous side effects within 20 weeks of beginning im gold therapy, at a time when RA had improved markedly compared to pretreatment status.

beginning

mucocutaneous side effects

im gold therapy

gold

im

within 20 weeks

RA


Input: Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.

after

Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis

Two

seizures and transient blindness

i.v. pulse methylprednisolone (IVPMP) treatment

idiopathic nephrotic syndrome

endo-extracapillary glomerulonephritis,

methylprednisolone

i.v. pulse


Input: Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy.

during

a boy with nephrotic syndrome

boy

Stevens-Johnson syndrome

prednisolone

prednisolone

nephrotic syndrome


Input: To our knowledge, this is the first report of an angio-oedema associated with VRC.

associated

angio-oedema

VRC

VRC


Input: Insulin-induced cardiac failure.

induced

cardiac failure

Insulin

Insulin


Input: The symptoms disappeared with clemastine and betametasone treatment.

disappeared

The symptoms disappeared

clemastine and betametasone

clemastine

betametasone

betametasone

clemastine


Input: This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.

drug-induced

toxic epidermal necrolysis

ofloxacin

ofloxacin


Input: Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.

of

nephrotoxicity

evaluation of renal failure

lithium

lithium


Input: A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator.

developed

A 56-year-old male parkinsonian patient

male

parkinsonian

a unique behavioral change

the oral administration of cinepazide, a cerebral vasodilator

cinepazide

oral administration


Input: The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia.

responsible

dystonia

carbamazepine

carbamazepine


Input: Metamizole, a nonsteroidal antiinflammatory agent, is prohibited in the United States because of the risk of agranulocytosis but is widely used in Mexico and other countries.

risk

agranulocytosis

Metamizole

Metamizole


Input: We conclude that the use of hemopoietic colony stimulating factors might be a suitable means to achieve the correction of severe thionamide-induced hematologic adverse reactions.

induced

hematologic adverse reactions.

thionamide

thionamide


Input: Two case reports of bilateral granulomatous anterior uveitis are described in patients with open angle glaucoma treated with metripranolol 0.6% eye drops.

treated

Two case reports of bilateral granulomatous anterior uveitis

patients with open angle glaucoma

Two

bilateral granulomatous anterior uveitis

metripranolol 0.6% eye drops

open angle glaucoma

metripranolol

eye drops


Input: Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.

complication

life-threatening bronchospasm

propranolol

propranolol


Input: In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine.

developed

2 female patients

female

incontinence

the selective serotonin reuptake inhibitors paroxetine and sertraline

paroxetine

sertraline

venlafaxine

paroxetine

sertraline


Input: Presented is a case story of a woman with classical rheumatoid arthritis, who during introduction of sulphasalazine (SASP) therapy developed a severe and lasting psoriasis-like skin reaction.

developed

a woman with classical rheumatoid arthritis

woman

psoriasis-like skin reaction

during introduction of sulphasalazine (SASP) therapy

sulphasalazine

classical rheumatoid arthritis


Input: Interstitial granulomatous dermatitis associated with darifenacin.

associated

Interstitial granulomatous dermatitis

darifenacin

darifenacin


Input: Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole.

induced

visual impairment

methanol

methanol


Input: Proton-pump inhibitors (PPIs) are believed to decrease the risk of such complications, though no randomized trial has proved this in patients receiving dual antiplatelet therapy.

believed

Proton-pump inhibitors (PPIs)

Proton-pump inhibitors (PPIs)

antiplatelet


Input: The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.

responsible

rhabdomyolysis as well as the delirium

caffeine, which is present in oolong tea

caffeine


Input: Prevention of CNS relapse was satisfactorily achieved with HD IV MTX and intrathecal injections of MTX in children with increased-risk ALL or stage III and IV lymphoblastic lymphoma treated with our BFM-based treatment protocol in which cranial irradiation was omitted.

Prevention

children with increased-risk ALL or stage III and IV lymphoblastic lymphoma

increased-risk ALL or stage III and IV lymphoblastic lymphoma

children

HD IV MTX and intrathecal injections of MTX

CNS relapse

MTX

MTX

intrathecal injections

HD IV

MTX

MTX


Input: Generalized lichen nitidus with involvement of the palms following interferon alpha treatment.

following

Generalized lichen nitidus with involvement of the palms

interferon alpha treatment

interferon alpha


Input: Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy.

significant toxic effect

Hemorrhagic cystitis

cyclophosphamide

cyclophosphamide


Input: Secondary hyperparathyroidism in certain patients with lithium nephrotoxicity is also possible.

in

certain patients

nephrotoxicity

Secondary hyperparathyroidism

lithium

lithium


Input: We report a case in which hemorrhage occurred in an asymptomatic falx meningioma known beforehand, after the internal use of low-dose aspirin for 16 months.

occurred

a case

hemorrhage

low-dose aspirin for 16 months

low-dose

aspirin

16 months


Input: Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain, and none of the 16 who were receiving digoxin.

receiving

four out of six

electrocardiographical changes

ouabain

ouabain


Input: The allergic reaction started to develop after co-administration of pravastatin.

develop

allergic reaction

co-administration of pravastatin

pravastatin


Input: We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.

associated

hepatic angiosarcoma

cyclophosphamide

cyclophosphamide


Input: The ocular motor disturbances are probably an expression of regional 5-FU neurotoxicity primarily affecting the brain stem.

expression

The ocular motor disturbances

neurotoxicity


Input: Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity.

nephrotoxicity

an eight-year old boy

boy

eight-year old

nephrotoxicity

cisplatinum

cisplatinum


Input: Bacterial infection is a frequent event in renal transplant recipients and often requires the use of antimicrobial agents.

event

renal transplant recipients

renal transplant

Bacterial infection

antimicrobial agents

antimicrobial agents


Input: Study results suggest that ciclesonide significantly reduces the need for OCS in patients with severe, persistent asthma, while maintaining asthma control.

reduces

patients with severe, persistent asthma

ciclesonide

OCS

ciclesonide

severe, persistent asthma


Input: CONCLUSION: This is, to our knowledge, the first report of severe myelopathy following accidental intrathecal administration of doxorubicin.

following

severe myelopathy

intrathecal administration of doxorubicin

doxorubicin

intrathecal administration


Input: Multiple sclerosis-like disease secondary to alpha interferon.

secondary

Multiple sclerosis-like disease

alpha interferon

alpha interferon


Input: We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis.

developed

a patient with mild chronic renal insufficiency

mild chronic renal insufficiency

acute weakness

taking simvastatin for over a year

3 weeks after the start of treatment with colchicine for acute gouty bursitis

acute gouty bursitis

simvastatin

colchicine

over a year

3 weeks

simvastatin

colchicine


Input: Shortly after chemotherapy and an injection of pegfilgrastim, the patient developed poorly defined, rapidly progressive erythema, edema, and pain in his right forearm.

developed

the patient

poorly defined, rapidly progressive erythema, edema, and pain in his right forearm

pegfilgrastim

pegfilgrastim


Input: To describe a probable interaction between enteral feeds and levodopa leading to neuroleptic malignant-like syndrome (NMLS) in a polytrauma patient with Parkinson's disease (PD).

leading

a polytrauma patient with Parkinson's disease (PD)

polytrauma

neuroleptic malignant-like syndrome (NMLS)

interaction between enteral feeds and levodopa

levodopa

enteral feeds

Parkinson's disease (PD)

enteral feeds

levodopa


Input: Second, we report a case of neutropenia, which proved to be fatal in a schizophrenia patient receiving olanzapine and thiazide.

receiving

a schizophrenia patient

neutropenia

olanzapine and thiazide

schizophrenia

olanzapine

thiazide

olanzapine

thiazide


Input: While mild to moderate application site reactions (ASRs) are a well-known and common phenomenon associated with imiquimod, the potential of TNF-alpha blockers to elicit cutaneous inflammatory reactions has only recently been recognized.

elicit

cutaneous inflammatory reactions

TNF-alpha blockers

TNF-alpha blockers


Input: Nineteen cases of allergic contact dermatitis to compound tincture of benzoin are described.

described.

Nineteen cases

Nineteen

allergic contact dermatitis

compound tincture of benzoin

benzoin


Input: We report 3 children with epilepsy who developed facial motor tics after initiation of CBZ for complex partial seizures.

after

3 children with epilepsy

children

facial motor tics

CBZ

epilepsy

CBZ


Input: The toxicity of cadmium, zinc and cadmium/zinc mixtures at concentrations ranging from 1000 to 50000 microg/l were investigated against cercariae and metacercariae of Parorchis acanthus obtained from the dog whelk Nucella lapillus.

against

toxicity

cadmium, zinc and cadmium/zinc mixtures at concentrations ranging from 1000 to 50000 microg/l

cadmium

zinc

cadmium

zinc

1000 to 50000 microg/l

cadmium

zinc


Input: We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-elonic seizures.

side-effect

a 29-year Nigerian female patient with generalized tonic-elonic seizures

Nigerian

female

syndrome of inappropriate antidiuresis

carbamazepine

carbamazepine

much earlier

generalized tonic-elonic seizures


Input: A patient was treated with warfarin for atrial fibrillation.

treated

A patient

warfarin

atrial fibrillation

warfarin


Input: Mood stabilizer therapy and pravastatin: higher risk for adverse skin reactions?

risk

adverse skin reactions

Mood stabilizer therapy and pravastatin

Mood stabilizer

pravastatin

Mood stabilizer

pravastatin


Input: Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse.

secondary

Pulmonary leukostasis

all-trans retinoic acid

acute promyelocytic leukemia in first relapse

all-trans retinoic acid


Input: A 74-year-old hypercholestrerolaemic woman taking cerivastatin (0.15 mg/day) for 22 days complained of general muscle weakness and muscle pain.

complained

A 74-year-old hypercholestrerolaemic woman

woman

general muscle weakness and muscle pain.

cerivastatin (0.15 mg/day)

cerivastatin

0.15 mg/day

22 days

hypercholestrerolaemic


Input: There have been only two reports of cimetidine-induced hepatitis.

induced

hepatitis

cimetidine

cimetidine


Input: A case is reported of theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine.

due

theophylline intoxication

concomitant administration of viloxazine

theophylline

viloxazine

viloxazine

theophylline


Input: Anterior ischemic optic neuropathy secondary to interferon alfa.

secondary

Anterior ischemic optic neuropathy

interferon alfa

interferon alfa


Input: PURPOSE: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon alpha administration.

occurred

bilateral optic neuritis

recombinant and natural interferon alpha administration

recombinant and natural interferon alpha


Input: Rofecoxib, used for dysmenorrhea, caused a herpetiform fixed drug eruption predominantly involving the lips with classic clinical and histological findings in a red-brown lesion on the dorsal hand.

caused

herpetiform fixed drug eruption predominantly involving the lips with classic clinical and histological findings in a red-brown lesion on the dorsal hand

Rofecoxib

dysmenorrhea

Rofecoxib


Input: Statin-associated myasthenia gravis: report of 4 cases and review of the literature.

associated

4 cases

myasthenia gravis

Statin

Statin


Input: Two reports of spindle coma are noted with alcohol and imipramine.

noted

Two reports

Two

spindle coma

alcohol and imipramine

alcohol

imipramine

alcohol

imipramine


Input: Cataracts induced by intermittent Decadron used as an antiemetic.

induced

Cataracts

Decadron

Decadron


Input: Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide.

present

two epileptic patients

two

osteomalacia

long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide

epileptic

phenytoin

phenobarbital

acetazolamide

phenytoin

phenobarbital

acetazolamide


Input: Careful observations on hepatotoxicity are suggested when acetaminophen is prescribed with caffeine.

with

hepatotoxicity

acetaminophen

caffeine

acetaminophen

caffeine


Input: Erosion of psoriatic plaques: an early sign of methotrexate toxicity.

of

Erosion of psoriatic plaques

methotrexate

methotrexate


Input: After extensive neurological 'work up', we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid.

related

anisocoria

transdermal scopolamine patch

scopolamine

transdermal

patch

weaning off the opioid


Input: Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial.

in

tifacogin (recombinant tissue factor pathway inhibitor)

severe sepsis

tifacogin (recombinant tissue factor pathway inhibitor)


Input: CASE: A malignant mixed mesodermal tumor was diagnosed in a 64-year-old woman with a bicornuate uterus while she was taking raloxifene for osteoporosis prevention.

diagnosed

a 64-year-old woman with a bicornuate uterus

woman

bicornuate uterus

A malignant mixed mesodermal tumor

raloxifene

raloxifene

osteoporosis


Input: After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.

responsible

hepatic enzyme disturbances reappeared

hepatitis

pegvisomant

within a few weeks

pegvisomant


Input: To evaluate the long-term (up to 5 years exposure) safety and efficacy of lacosamide as adjunctive therapy in patients with uncontrolled partial-onset seizures taking one to three concomitant antiepileptic drugs (AEDs) in open-label extension trial SP756 (NCT00522275).

in

long-term (up to 5 years exposure)

lacosamide as adjunctive therapy

taking one to three concomitant antiepileptic drugs (AEDs)

uncontrolled partial-onset seizures

lacosamide

antiepileptic drugs

long-term (up to 5 years exposure)

lacosamide

antiepileptic drugs


Input: Complete remission of the nephrosis occurred after discontinuation of hydroxychloroquine therapy.

occurred

nephrosis

discontinuation of hydroxychloroquine

discontinuation

hydroxychloroquine


Input: CONCLUSIONS: Clinicians treating elderly patients with olanzapine should be aware of the potential for rapidly developing hyperglycemia and monitor such patients accordingly.

with

elderly patients

elderly

rapidly developing hyperglycemia

olanzapine

olanzapine


Input: We describe a case of PRES in a patient with collapsing focal glomeruloesclerosis (collapsing FGS) with complete recovery after withdrawal of cyclosporine (CSA).

complete recovery

a patient with collapsing focal glomeruloesclerosis (collapsing FGS)

collapsing focal glomeruloesclerosis

withdrawal of cyclosporine (CSA)

PRES

cyclosporine


Input: DISCUSSION: The occurrence of priapism in our patient was related to zuclopenthixol.

related

our patient

priapism

zuclopenthixol

zuclopenthixol


Input: Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature.

occurring

Hepatic angiosarcoma

cyclophosphamide therapy

cyclophosphamide


Input: After completion of induction-consolidation phase, children with increased-risk (risk factor > 0.8 or T-lineage) ALL or stage III and IV lymphoblastic lymphoma were randomized to receive four courses of HD MTX (5 g/m(2) over 24 hours every 2 weeks) and four intrathecal administrations of MTX (Arm A) or the same treatment schedule with additional HD IV Ara-C (1 g/m(2) in bolus injection 12 and 24 hours after the start of each MTX infusion) (Arm B).

receive

children with increased-risk (risk factor > 0.8 or T-lineage) ALL or stage III and IV lymphoblastic lymphoma

children

After completion of induction-consolidation phase

four courses of HD MTX (5 g/m(2) over 24 hours every 2 weeks) and four intrathecal administrations of MTX (Arm A) or the same treatment schedule with additional HD IV Ara-C (1 g/m(2) in bolus injection 12 and 24 hours after the start of each MTX infusion) (Arm B)

lymphoblastic lymphoma

HD MTX

MTX

HD IV Ara-C

MTX

5 g/m(2)

1 g/m(2)

over 24 hours every 2 weeks

bolus injection

MTX

HD IV Ara-C


Input: The dose-limiting toxicity of KW-2149 is pulmonary toxicity.

toxicity.

pulmonary


Input: Flucloxacillin-induced aplastic anaemia and liver failure.

induced

aplastic anaemia and liver failure

Flucloxacillin

Flucloxacillin


Input: Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.

induced

patients with cancer

cancer

anaphylaxis

methotrexate

methotrexate


Input: We further used immunohistochemistry (IHC) to examine the relative role of platelet-derived growth factor-B (PDGF-B), insulin-like growth factor I (IGF-I), transforming growth factor-beta1 (TGF-beta1) and cyclooxygenase-2 (COX-2) in the pathogenesis of BCNU-related pulmonary fibrosis.

related

pulmonary fibrosis

BCNU

BCNU


Input: Physicians using this "new" drug must be aware of the potential danger of sulfonamide-induced injury to the urinary tract.

induced

injury to the urinary tract

sulfonamide

sulfonamide


Input: RESULTS: Brimonidine was observed to cause IOP elevation, confirmed on rechallenge, scoring 8 (strong probability) on an adverse drug reaction probability score.

cause

IOP elevation

Brimonidine

Brimonidine


Input: Severe leukopenia associated with mild hepatotoxicity in an HIV carrier treated with nevirapine.

with

an HIV carrier

leukopenia

nevirapine

nevirapine

HIV carrier


Input: The clinical effect and safety of Lp-TAE alone and combined with radiofrequency (RF) capacitive hyperthermia (HT) were evaluated in 20 patients with hepatocellular carcinoma (HCC) associated with cirrhosis of the liver.

effect and safety

20 patients with hepatocellular carcinoma (HCC)

hepatocellular carcinoma

Lp-TAE alone and combined with radiofrequency (RF) capacitive hyperthermia (HT)

Lp-TAE

radiofrequency (RF) capacitive hyperthermia

cirrhosis of the liver

Lp-TAE

radiofrequency (RF) capacitive hyperthermia


Input: Fibrosis of corpus cavernosum after intracavernous injection of phentolamine/papaverine.

after

Fibrosis of corpus cavernosum

intracavernous injection of phentolamine/papaverine

phentolamine

papaverine

intracavernous injection

phentolamine

papaverine


Input: We have cared for three children in whom four episodes of dystonia proceeding to opisthotonus occurred in association with carbamazepine use.

occurred

three children

three

children

four episodes of dystonia proceeding to opisthotonus

carbamazepine

carbamazepine


Input: Juvenile absence epilepsy exacerbated by valproic acid.

exacerbated

Juvenile absence epilepsy

Juvenile

Juvenile absence epilepsy exacerbated

valproic acid

valproic acid

absence epilepsy


Input: These cases were chosen for study because they were all deaths as a result of suicidal ingestion of drugs in which quetiapine was considered a significant factor.

considered

they were all deaths

quetiapine

quetiapine


Input: We present a case of hypereosinophilia related to zafirlukast therapy.

related

a case

hypereosinophilia

zafirlukast therapy.

zafirlukast


Input: In patients with methotrexate-induced anaphylaxis, discontinuation of treatment may increase the risk of death due to cancer progression.

discontinuation

In patients with methotrexate-induced anaphylaxis

death due to cancer progression

treatment

methotrexate-induced anaphylaxis


Input: Pentazocine-induced fibrous myopathy and localized neuropathy.

induced

fibrous myopathy and localized neuropathy

Pentazocine

Pentazocine


Input: Intensive high-flux hemodiafiltration is often used in the management of vancomycin toxicity.

management

Intensive high-flux hemodiafiltration

vancomycin toxicity


Input: Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin.

after

a patient with hepatitis C

a generalized lichen nitidus with involvement of the palms

systemic treatment with interferon alpha and ribavirin

hepatitis C

interferon alpha

ribavirin

systemic

ribavirin

interferon alpha


Input: The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.

after

a woman with chronic schizophrenia

woman

delirium, grand mal seizure, and photosensitivity

propranolol

propranolol

chronic schizophrenia


Input: We report a case of an infant with complex congenital heart disease who was placed on captopril for afterload reduction following cardiac surgery and subsequently developed pulmonary infiltrates with eosinophilia.

developed

an infant with complex congenital heart disease

infant

pulmonary infiltrates with eosinophilia

captopril

captopril

congenital heart disease


Input: Possible pathophysiological mechanisms which may have been operative in this case include: a direct central nervous system (CNS) toxic effect of valproic acid; a paradoxical epileptogenic effect secondary to the drug; and an indirect CNS toxic effect mediated through valproic acid-induced hyperammonemia.

induced

a direct central nervous system (CNS) toxic effect

a paradoxical epileptogenic effect

hyperammonemia

valproic acid

valproic acid


Input: We report a case of serotonin syndrome induced by pharmacokinetic and pharmacodynamic interactions between three different selective serotonin-reuptake inhibitors (SSRI) and possibly ciprofloxacin.

induced

a case

serotonin syndrome

interactions between three different selective serotonin-reuptake inhibitors (SSRI) and possibly ciprofloxacin

selective serotonin-reuptake inhibitors

ciprofloxacin

ciprofloxacin

selective serotonin-reuptake inhibitors


Input: Generalised pustular psoriasis induced by cyclosporin a withdrawal responding to the tumour necrosis factor alpha inhibitor etanercept.

induced

Generalised pustular psoriasis

cyclosporin a withdrawal

cyclosporin


Input: A 36-y-o patient with schizophrenia, who had consumed gradually increasing quantities of oolong tea that eventually reached 15 L each day, became delirious and was admitted to a psychiatric hospital.

became

A 36-y-o patient with schizophrenia

schizophrenia

delirious

gradually increasing quantities of oolong tea that eventually reached 15 L each day

15 L

each day

oolong tea


Input: Intraventricular nafcillin-induced seizures in a neonate.

induced

a neonate

neonate

Intraventricular

seizures

nafcillin

nafcillin


Input: Nevertheless, the coagulopathy seemed to be most closely associated with the administration of the cephalosporin.

associated with

coagulopathy

cephalosporin

cephalosporin


Input: Intrahepatic cholestasis and sicca complex after thiabendazole.

after

Intrahepatic cholestasis and sicca complex

thiabendazole

thiabendazole


Input: We recommended periodic examination of the serum proteins in patients receiving diphenylhydantoin in order to detect development of monoclonal gammopathy.

receiving

patients

detect development of monoclonal gammopathy

diphenylhydantoin

diphenylhydantoin


Input: Moxalactam is more likely to be associated with platelet dysfunction.

associated

platelet dysfunction

Moxalactam

Moxalactam


Input: This prompted us to suspect that ddI might be responsible for fulminant hepatitis in all three AIDS patients.

be responsible for

three AIDS patients

three

fulminant hepatitis

ddI

AIDS

ddI


Input: Two patients, each receiving warfarin for stroke prophylaxis in association with chronic atrial fibrillation, developed adverse effects after the initiation of tolterodine for urinary disorders.

developed

Two patients

Two

chronic atrial fibrillation

adverse effects

receiving warfarin for stroke prophylaxis in association with chronic atrial fibrillation

after the initiation of tolterodine for urinary disorders

stroke

urinary disorders

tolterodine

warfarin

tolterodine

warfarin


Input: CASE SUMMARY: A 45-year-old HIV-positive man (CD4+ count 450 cells/mm(3) and history of AIDS-defining illness) presented with JHR after an initial intravenous dose of penicillin G for presumed neurosyphilis.

after

A 45-year-old HIV-positive man (CD4+ count 450 cells/mm(3) and history of AIDS-defining illness)

HIV-positive

JHR

an initial intravenous dose of penicillin G

penicillin G

neurosyphilis

intravenous

an initial intravenous dose


Input: The second patient developed both autoimmune thyroid disease and a refractory pre-patellar bursitis after 50 months of IFN-beta therapy.

developed

second patient

both autoimmune thyroid disease and a refractory pre-patellar bursitis

50 months of IFN-beta therapy

IFN-beta

50 months


Input: We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.

teratogenicity

patient

agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts

isotretinoin

isotretinoin


Input: Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.

due

Reversible sclerotic changes of lumbar spine and femur

long-term oral isotretinoin

isotretinoin

oral

long-term


Input: A case of priapism associated with trazodone is described.

associated

A case

priapism

trazodone

trazodone


Input: Severe adenovirus pneumonia (AVP) following infliximab infusion for the treatment of Crohn's disease.

following

adenovirus pneumonia

infliximab infusion

infliximab

infusion

Crohn's disease


Input: No other endogenous or exogenous cause for the gynecomastia could be found except for the theophylline.

cause

gynecomastia

theophylline

theophylline


Input: This is a case of pseudoephedrine-induced intracerebral hemorrhage in a patient with an underlying vascular malformation.

induced

a patient with an underlying vascular malformation

vascular malformation

intracerebral hemorrhage

pseudoephedrine

pseudoephedrine


Input: A 58-year-old woman developed unilateral acute angle-closure glaucoma four days after the application of a patch of transdermal scopolamine delivery system (TRANSDERM-V).

after

A 58-year-old woman

woman

unilateral acute angle-closure glaucoma

four days after the application of a patch of transdermal scopolamine delivery system (TRANSDERM-V)

patch

scopolamine

four days


Input: We report a 50-year-old male patient with a 15-year history of psoriasis including mutilating psoriatic arthritis, in whom the withdrawal of cyclosporin A induced a generalised pustular exacerbation and a aggravation of the joint condition.

induced

a 50-year-old male patient with a 15-year history of psoriasis including mutilating psoriatic arthritis

male

psoriasis including mutilating psoriatic arthritis

a generalised pustular exacerbation and a aggravation of the joint condition

the withdrawal of cyclosporin A

cyclosporin A


Input: Six days after starting acyclovir she exhibited signs of lithium toxicity.

after

she

she

lithium toxicity

Six days after starting acyclovir

Six days

acyclovir


Input: Toxicity of cadmium and zinc to encystment and in vitro excystment of Parorchis acanthus (Digenea: Philophthalmidae).

Toxicity

Toxicity

cadmium and zinc

cadmium

zinc


Input: The syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).

effectuated

syndrome of irreversible lithium-effectuated neurotoxicity (SILENT)

lithium

lithium


Input: One patient on ouabain also developed cardiomyopathy.

developed

One patient

One

cardiomyopathy

ouabain

ouabain


Input: Data suggest that tamoxifen is involved in the pathogenesis.

involved

pathogenesis

tamoxifen

tamoxifen


Input: Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy.

associated

Intrahepatic cholestasis and cutaneous bullae

glibenclamide therapy

glibenclamide


Input: Prolonged-release oxycodone enhances the effects of existing gabapentin therapy in painful diabetic neuropathy patients.

enhances

painful diabetic neuropathy patients

Prolonged-release oxycodone

gabapentin therapy

Prolonged-release oxycodone

diabetic neuropathy


Input: OBJECTIVE: To describe what is believed, as of November 4, 2003, to be the first case published in the literature of acute interstitial nephritis (AIN) due to pantoprazole.

due

acute interstitial nephritis (AIN)

pantoprazole

pantoprazole


Input: We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole.

developed

a patient of organic bipolar affective disorder

hiccups

the atypical antipsychotic aripiprazole

organic bipolar affective disorder

aripiprazole


Input: A 28 year-old man with chronic hepatitis B was administered interferon-alpha (5 x 10(6) IU) intramuscularly once a day for 28 days.

administered

A 28 year-old man with chronic hepatitis B

28 year-old

man

interferon-alpha (5 x 10(6) IU) intramuscularly once a day for 28 days

chronic hepatitis B

interferon-alpha

intramuscularly

once a day


Input: The case of a patient taking high-dosage olanzapine who experienced parkinsonism after smoking cessation is reported.

experienced

a patient

parkinsonism

high-dosage olanzapine

smoking cessation

high-dosage

olanzapine


Input: A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression.

following

A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy

woman

bipolar disorder

cardiovascular disease

a movement disorder

high doses of trazodone

trazodone

lithium

high doses

acute depression

lithium

trazodone


Input: The most common complication of warfarin use is adverse bleeding.

use

adverse bleeding

warfarin

warfarin


Input: To report a case of autonomic, neurological and neuromuscular instability following methylene blue infusion for parathyroidectomy; to advance the argument for a diagnosis of serotonin syndrome; and to consider this diagnosis in previous, unexplained reports of adverse reactions amongst patients undergoing parathyroidectomy using methylene blue.

following

autonomic, neurological and neuromuscular instability

methylene blue infusion for parathyroidectomy

methylene blue

infusion


Input: PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.

related

PVT

intensive chemotherapy containing busulfan and to be associated with HVOD

HVOD

busulfan

HVOD

busulfan

HVOD


Input: It is hoped that this case report creates awareness that ofloxacin-induced toxic epidermal necrolysis is possible.

induced

toxic epidermal necrolysis is possible

ofloxacin

ofloxacin


Input: Concomitant use of simvastatin and amiodarone resulting in severe rhabdomyolysis: a case report and review of the literature.

resulting

a case

rhabdomyolysis

Concomitant use of simvastatin and amiodarone

simvastatin

amiodarone

simvastatin

amiodarone


Input: CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.

cause

CDIC

clindamycin phosphate vaginal cream

clindamycin phosphate

vaginal cream


Input: A case of intercerebral hematoma due to warfarin-induced coagulopathy is presented.

induced

coagulopathy

intercerebral hematoma

warfarin

warfarin


Input: Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma.

after

a patient with spinal cord astrocytoma

Severe visual loss

a single dose of vincristine

spinal cord astrocytoma

vincristine

a single dose


Input: Clonazepam, thioridazine, beta-blockers, anticholinergics, and bromocriptine did not ameliorate his akathisia.

ameliorate

his

his

Clonazepam, thioridazine, beta-blockers, anticholinergics, and bromocriptine

akathisia

Clonazepam

thioridazine

beta-blockers

anticholinergics

bromocriptine


Input: Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.

with

four of 44 children (9%)

four of 44

children

Musculoskeletal complaints

ifosfamide

relapsed Wilms' tumors

ifosfamide


Input: Cutaneous exposure to warfarin-like anticoagulant causing an intracerebral hemorrhage: a case report.

causing

a case

an intracerebral hemorrhage

Cutaneous exposure to warfarin-like anticoagulant

warfarin-like anticoagulant


Input: Gemcitabine should be added to the list of drugs known to cause radiation recall.

cause

radiation recall

Gemcitabine

Gemcitabine


Input: A paradoxical ocular effect of brimonidine.

of

paradoxical ocular effect

brimonidine

brimonidine


Input: Fixed drug eruption to rofecoxib.

to

Fixed drug eruption

rofecoxib

rofecoxib


Input: DISCUSSION: No published clinical studies in patients receiving clindamycin vaginal cream for bacterial vaginosis have documented C. difficile toxin in stool samples of patients with diarrhea.

for

patients

receiving clindamycin vaginal cream

clindamycin

vaginal cream

bacterial vaginosis


Input: Acute interstitial nephritis due to pantoprazole.

due

Acute interstitial nephritis

pantoprazole

pantoprazole


Input: Physicians should keep in mind that taxanes such as paclitaxel have the potential to cause pneumonitis and lung fibrosis.

cause

pneumonitis and lung fibrosis

taxanes such as paclitaxel

taxanes


Input: Infant twins sustained severe circumoral and pharyngeal burns from a concentrated solution of benzalkonium (Zephiran) chloride prescribed for treatment of candidiasis.

sustained

Infant twins

Infant

severe circumoral and pharyngeal burns

a concentrated solution of benzalkonium (Zephiran) chloride

candidiasis

benzalkonium (Zephiran) chloride