Input: After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.

After

jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy

parenteral amiodarone (2300 mg in 3 days) and other measures

amiodarone

parenteral

2300 mg in 3 days

congestive heart failure


Input: We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period.

taking

a patient, with a 30-year history of rheumatoid arthritis

a

non-Hodgkin lymphoma

low dose methotrexate weekly over a 10-month period

rheumatoid arthritis

methotrexate

weekly

10-month period.

low dose


Input: We recommend the cautious use of alum irrigation in patients with renal impairment and monitoring of serum aluminum levels to prevent excessive accumulation and toxicity.

to

patients

excessive accumulation and toxicity.

alum irrigation

renal impairment

alum

irrigation


Input: RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.

presented

a 20-year-old woman

woman

tense bullae and cutaneous fragility on the face and the back of the hands

oxaprozin

rheumatoid arthritis

oxaprozin


Input: CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.

occurring

middle-aged man who suffered from chronic sinusitis

middle-aged

man

intracerebral hemorrhage

ingesting pseudoephedrine daily for one year

ingesting

pseudoephedrine

daily

for one year

chronic sinusitis


Input: Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.

developing

a patient with rheumatoid arthritis

Lymphoma

methotrexate

methotrexate

rheumatoid arthritis


Input: The Naranjo probability scale suggests a highly probable relationship between AIN and pantoprazole therapy in this patient.

relationship

patient

AIN

pantoprazole

pantoprazole


Input: In one case, disulfiram was the only potential teratogen exposed to the fetus.

exposed

fetus

fetus

teratogen

disulfiram

disulfiram


Input: Pancreatitis has been noted to be a complication in 2-16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms.

complication

in 2-16% of patients

Pancreatitis

L-asparaginase for a variety of pediatric neoplasms

a variety of pediatric neoplasms

L-asparaginase


Input: Myopathy, including rhabdomyolysis, is a well-known, albeit rare complication of statin therapy.

complication

Myopathy, including rhabdomyolysis

statin

statin


Input: Management and successful desensitization in methotrexate-induced anaphylaxis.

induced

anaphylaxis

methotrexate

methotrexate


Input: Mitomycin-C induced hemolytic uremic syndrome: a case report.

induced

hemolytic uremic syndrome

Mitomycin-C

Mitomycin-C


Input: Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism.

complication

Acute hepatic failure

propylthiouracil (PTU)

hyperthyroidism

propylthiouracil


Input: Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.

on

a patient

Monoclonal gammopathy and subsequent multiple myeloma

chronic diphenylhydantoin therapy.

chronic

diphenylhydantoin


Input: Unexpected severe reversible cyclosporine A-induced nephrotoxicity in a patient with systemic lupus erythematosus and tubulointerstitial renal disease.

induced

a patient with systemic lupus erythematosus and tubulointerstitial renal disease

nephrotoxicity

cyclosporine A

cyclosporine A

systemic lupus erythematosus

tubulointerstitial renal disease


Input: As far as we know, this is the first case report of acute hemorrhagic gastritis associated with AZ intoxication.

associated

acute hemorrhagic gastritis

AZ intoxication

AZ

AZ


Input: Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.

after

Toxic epidermal necrolysis

19 days of treatment with 5-fluorocytosine and amphotericin B.

19 days

amphotericin B.

amphotericin B.


Input: Since 1979, over 30 published case reports have documented the relationship between phenylpropanolamine and stroke.

relationship

stroke

phenylpropanolamine

phenylpropanolamine


Input: CASE SUMMARY: A 61-year-old woman with no apparent risk factors for liver injury developed acute hepatitis one week after the final dose of a long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk) for onychomycosis.

developed

A 61-year-old woman with no apparent risk factors for liver injury

woman

acute hepatitis

long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk)

onychomycosis

itraconazole

200 mg

orally

twice daily


Input: We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication.

associated with

a case of chronic renal failure in a patient

chronic renal failure

acute hemorrhagic gastritis

AZ

AZ


Input: Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy.

caused

a pregnant patient with myotonic dystrophy

myotonic dystrophy

Rhabdomyolysis

tocolysis with oral ritodrine hydrochloride

oral

ritodrine hydrochloride


Input: While sulindac failed to affect significantly warfarin-induced hypoprothrombinemia in normal male volunteers, it markedly prolonged prothrombin time in a patient with a renal tubular defect who had been anticoagulated with warfarin.

in

a patient with a renal tubular defect

renal tubular defect

markedly prolonged prothrombin time

sulindac

had been anticoagulated with warfarin

sulindac

warfarin

warfarin

sulindac


Input: Painful erosion of psoriatic plaques is a less common sign of methotrexate toxicity that may precede evidence of bone marrow suppression.

sign

Painful erosion of psoriatic plaques

methotrexate toxicity

bone marrow suppression

methotrexate

methotrexate

psoriatic plaques


Input: Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.

induced

an acromegalic patient

hepatitis

combined treatment with pegvisomant and octreotide long-acting repeatable

acromegalic

pegvisomant

octreotide

pegvisomant

octreotide


Input: We report the first case of a patient in a promethazine-induced coma responding to treatment with flumazenil.

responding to

a patient in a promethazine-induced coma

treatment with flumazenil

flumazenil

promethazine

coma


Input: Ocular hypertension occurred 1 month after the second ranibizumab injection in patients 1 and 3, and 1 month after the first ranibizumab in patient 2.

occurred

patients 1 and 3

in patient 2

Ocular hypertension

1 month after the second ranibizumab injection

ranibizumab

ranibizumab

1 month after the second

1 month after the first

injection


Input: Priapism associated with zuclopenthixol.

associated

Priapism

zuclopenthixol

zuclopenthixol


Input: Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy.

association

Reversible MR imaging and MR spectroscopy abnormalities

metronidazole therapy

metronidazole


Input: PURPOSE: The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.

resulting

corneal endothelial deposits

rifabutin

rifabutin


Input: OBJECTIVE: To report a case of calcineurin-induced pain syndrome (CIPS) in a child undergoing his second hematopoietic stem cell transplant (HSCT).

induced

a child undergoing his second hematopoietic stem cell transplant (HSCT)

child

his

pain syndrome (CIPS)

calcineurin

calcineurin

hematopoietic stem cell transplant


Input: We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.

resulting

a male patient with psoriasis and hypertension

male

hypercalciuria and hypercalcemia

tacalcitol ointment and thiazide

psoriasis

hypertension

tacalcitol

thiazide

ointment

tacalcitol

thiazide


Input: To our knowledge, this is the first granulomatous reaction described after calcium hydroxylapatite injection.

after

granulomatous reaction

calcium hydroxylapatite injection

calcium hydroxylapatite

injection


Input: Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.

manifestations

acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia

MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs)

MTX

non-steroidal, anti-inflammatory drugs


Input: We present a case report of a patient with alveolar hydatid disease, whose treatment with mebendazole was brief due to side effects of alopecia and granulocytopenia; and review the features of this disease which, with increasing international migration, may be encountered more frequently in Australia.

due

a patient with alveolar hydatid disease

alopecia and granulocytopenia

mebendazole

mebendazole

alveolar hydatid disease


Input: Niacin causes a reversible toxic cystoid maculopathy that occurs in approximately 0.67% of patients taking high doses of the drug.

causes

approximately 0.67% of patients

reversible toxic cystoid maculopathy

Niacin

high doses

Niacin

high doses


Input: When tuberculosis patients on isoniazid eat certain varieties of fish they may develop a histamine reaction.

develop

tuberculosis patients

histamine reaction

isoniazid

isoniazid

tuberculosis


Input: CONCLUSIONS: Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.

serious adverse effect

Priapism

zuclopenthixol

zuclopenthixol


Input: To report a case of possible interaction of smokeless tobacco with warfarin in a patient treated after several thromboembolic events.

treated

possible interaction of smokeless tobacco with warfarin

warfarin

several thromboembolic events

warfarin


Input: Hepatotoxicity induced by cyproterone acetate: a report of three cases.

induced by

Hepatotoxicity

cyproterone acetate

cyproterone acetate


Input: Neurotoxicity of intrathecal methotrexate: MR imaging findings.

of

Neurotoxicity

intrathecal methotrexate

intrathecal

methotrexate


Input: Isonicotinic acid hydrazide induced anagen effluvium and associated lichenoid eruption.

induced

anagen effluvium and associated lichenoid eruption

Isonicotinic acid hydrazide

Isonicotinic acid hydrazide


Input: Only one case of severe symptomatic hepatitis occurring after pulse therapy with itraconazole for onychomycosis and requiring transplantation has been reported previously.

occurring

one case

one

severe symptomatic hepatitis

pulse therapy with itraconazole

onychomycosis

itraconazole


Input: The elicitation of a movement disorder by trazodone: case report.

by

movement disorder

trazodone

trazodone


Input: Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.

subsequent

Pulmonary fibrosis

high doses of CCNU

chronic myeloid leukemia

high doses

CCNU


Input: PURPOSE/OBJECTIVES: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy.

predisposes

dihydropyrimidine dehydrogenase (DPD) deficiency

dihydropyrimidine dehydrogenase (DPD) deficiency

lethal adverse reactions

5-fluorouracil (5-FU)-based chemotherapy

cancer

chemotherapy


Input: We report a case of sustained hypotension after administration of parenteral verapamil.

after

sustained hypotension

administration of parenteral verapamil

verapamil


Input: Methadone has two roles in human immunodeficiency viral infection: pain management and treatment of opioid abuse.

has two roles

pain management and treatment of opioid abuse

Methadone

human immunodeficiency viral infection

Methadone


Input: Each time he arrived at the anticoagulation clinic after his BCG therapy, his INR was supratherapeutic, except after his fourth treatment (INR of 2.5), which can be explained by residual effects from the phytonadione he received a week earlier.

residual effects

INR was supratherapeutic

BCG

phytonadione

BCG

phytonadione

a week earlier

after his fourth treatment

BCG

phytonadione


Input: A 70-year-old man had been treated with warfarin for atrial fibrillation.

treated

A 70-year-old man

man

warfarin

warfarin

atrial fibrillation


Input: This is a case report of fatal cryptococcal meningitis in a child with systemic lupus erythematosus being treated with prednisolone and azathioprine.

in

a child with systemic lupus erythematosus

child

fatal cryptococcal meningitis

prednisolone and azathioprine

systemic lupus erythematosus

prednisolone

azathioprine

prednisolone

azathioprine


Input: Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.

associated

a patient with chronic renal failure

chronic renal failure

Acute hemorrhagic gastritis

acetazolamide

acetazolamide


Input: Although the movement disorder could not with certainty be attributed to trazodone alone, the drug at least acted as an eliciting agent.

attributed

movement disorder

trazodone

trazodone


Input: CONCLUSIONS: Prolonged exposure to itraconazole, administered either continuously or intermittently, may precipitate severe and irreversible hepatotoxic events.

precipitate

severe and irreversible hepatotoxic events

Prolonged exposure to itraconazole, administered either continuously or intermittently

itraconazole

Prolonged exposure

continuously or intermittently


Input: In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA).

developed

two patients with mycosis fungoides

two

squamous cell carcinoma

psoralens plus long-wave ultraviolet radiation (PUVA)

mycosis fungoides

psoralens


Input: Scrotal ulceration induced by all-trans retinoic acid in a patient with acute promyelocytic leukemia.

induced

a patient with acute promyelocytic leukemia.

Scrotal ulceration

all-trans retinoic acid

all-trans retinoic acid

acute promyelocytic leukemia


Input: A 61 year-old male patient developed gynecomastia after starting theophylline.

developed

A 61 year-old male patient

61 year-old

male

gynecomastia

theophylline

theophylline


Input: Several possible explanations of the mechanism of renal failure associated with the use of dextran-40 are discussed.

associated

renal failure


Input: We present a case of the syndrome of inappropriate antidiuretic hormone (SIADH) secondary to cisplatin therapy in a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix.

secondary

a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix

syndrome of inappropriate antidiuretic hormone (SIADH)

cisplatin therapy

cisplatin

advanced-stage large cell neuroendocrine carcinoma of the cervix


Input: An 80-year-old white female, followed up at the Memory Clinic for mild cognitive impairment, had been taking propafenone 900 mg/d for >10 years for paroxysmal atrial fibrillation without adverse effects.

for

An 80-year-old white female

white

female

mild cognitive impairment

propafenone 900 mg/d for >10 years

paroxysmal atrial fibrillation

propafenone

900 mg/d

>10 years


Input: A total of 109 patients had a cardiovascular event, with event rates of 4.9% with omeprazole and 5.7% with placebo (hazard ratio with omeprazole, 0.99; 95% CI, 0.68 to 1.44; P = 0.96); high-risk subgroups did not show significant heterogeneity.

had

109 patients

cardiovascular event

4.9% with omeprazole and 5.7% with placebo

omeprazole

placebo


Input: The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.

reaction

anaphylactoid

zomepirac

zomepirac


Input: New onset of CD may be considered as an immune-mediated injury induced by etanercept.

induced

CD

immune-mediated injury

etanercept

etanercept


Input: This supports the well-reported potential of bleomycin to trigger acral vascular toxicity.

trigger

acral vascular toxicity

bleomycin

bleomycin


Input: Results of a Phase III, double-blind, randomized, parallel-group, non-inferiority study evaluating the safety and efficacy of isotretinoin-Lidose in patients with severe recalcitrant nodular acne.

of

patients with severe recalcitrant nodular acne

evaluating the safety and efficacy

isotretinoin-Lidose

severe recalcitrant nodular acne

isotretinoin-Lidose


Input: This treatment has the potential to cause severe vision loss as a result of intractable corticosteroid-induced glaucoma.

induced

severe vision loss

glaucoma

corticosteroid

corticosteroid


Input: Therefore, parenteral amiodarone was implicated as the cause of acute hepatitis in this patient.

cause

this patient

acute hepatitis

parenteral amiodarone

amiodarone

parenteral


Input: Twenty-four hours after the administration of gemcitabine, a symmetric, bullous, herpetiform eruption appeared on his trunk and upper limbs.

after

a symmetric, bullous, herpetiform eruption appeared on his trunk and upper limbs

administration of gemcitabine

gemcitabine

Twenty-four hours


Input: The rate of overt upper gastrointestinal bleeding was also reduced with omeprazole as compared with placebo (hazard ratio, 0.13; 95% CI, 0.03 to 0.56; P = 0.001).

reduced

omeprazole

upper gastrointestinal bleeding

omeprazole

placebo


Input: The association of phenothiazine overdose and respiratory distress syndrome merits consideration.

association

respiratory distress syndrome

phenothiazine overdose

phenothiazine

overdose


Input: Patients from endemic areas referred to transplant centers may be at high risk for disseminated histoplasmosis when treated with long-term prednisone for graft-versus-host disease.

with

Patients

disseminated histoplasmosis

long-term prednisone

prednisone

graft-versus-host disease.


Input: Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.

induced

malignant transformation of endometriosis

tamoxifen

tamoxifen


Input: A 28 year old white schizophrenic male has been under risperidone monotherapy for about one year when he developed dyskinetic movements.

developed

A 28 year old white schizophrenic male

28 year old

white

male

dyskinetic movements

risperidone monotherapy

risperidone

about one year

schizophrenic


Input: Subjects receiving ivacaftor were 55% less likely to have a pulmonary exacerbation than were patients receiving placebo, through week 48 (P<0.001).

receiving

ivacaftor

pulmonary exacerbation

ivacaftor


Input: Spinal cord infarction during use of zolmitriptan: a case report.

during

Spinal cord infarction

use of zolmitriptan

zolmitriptan


Input: Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.

after

a 29-year-old woman

woman

bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction

22-month use of recombinant interferon alpha-2b

interferon alpha-2b

chronic myelogenous leukemia


Input: These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent.

occur

intrahepatic cholestasis

chlorpropamide

chlorpropamide


Input: Risperidone-induced tardive dyskinesia.

induced

tardive dyskinesia

Risperidone

Risperidone


Input: Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.

complication

toxicity

pentazocine

pentazocine


Input: Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.

observed

fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria

cyclosporine A

cyclosporine A


Input: Niacin maculopathy.

maculopathy.

maculopathy

Niacin

Niacin


Input: We report a case in which a potential drug interaction between clobazam and etravirine may have led to increased concentrations of clobazam and its pharmacologically active metabolite, N-desmethylclobazam, causing neurotoxic symptoms.

led

increased concentrations of clobazam and its pharmacologically active metabolite, N-desmethylclobazam

neurotoxic symptoms

interaction between clobazam and etravirine

etravirine

clobazam

clobazam

etravirine


Input: A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.

after

patients

hepatic angiosarcoma

long-term cyclophosphamide treatment

long-term

cyclophosphamide


Input: We present a case of cutaneous leucocytoclastic vasculitis in which amphotericin B might presumably be the aetiological factor.

be

a case

cutaneous leucocytoclastic vasculitis

amphotericin B

amphotericin B


Input: There have been numerous case reports of hyperglycemia with olanzapine in the literature, but none reported hyperglycemia within days of initiation of the medication.

with

hyperglycemia

olanzapine

olanzapine

within days of initiation


Input: This case report describes two severe antiretroviral drug adverse reactions that occurred in the same patient.

occurred

same patient

adverse reactions

antiretroviral drug

antiretroviral drug


Input: We report the first case presenting with successive anaphylactic reaction and extra-pyramidal syndrome after treatment with thiethylperazine maleate (thiethylperazine).

after

successive anaphylactic reaction and extra-pyramidal syndrome

treatment with thiethylperazine maleate (thiethylperazine)

thiethylperazine maleate


Input: Renal failure associated with the use of dextran-40.

associated

Renal failure


Input: Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy.

associated

Acute lung injury

5-fluorouracil and oxaliplatinum combined chemotherapy

oxaliplatinum

chemotherapy

oxaliplatinum


Input: Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications.

induced

thrombocytopenia

Type II heparin

heparin


Input: RESULTS: Similar to previous findings of drug-induced vortex keratopathy, atovaquone vortex keratopathy is presumably caused by its lipophilic properties.

caused

vortex keratopathy

atovaquone

its lipophilic properties

atovaquone


Input: Gangrene of the fingertips after bleomycin and methotrexate.

after

Gangrene of the fingertips

bleomycin and methotrexate

bleomycin

methotrexate

methotrexate

bleomycin


Input: These cases demonstrate that CBZ can induce simple motor tics in children.

induce

children

children

simple motor tics

CBZ

CBZ


Input: Esophageal spasm following propranolol overdose relieved by glucagon.

following

Esophageal spasm

propranolol overdose

propranolol

overdose


Input: She was thus diagnosed as having AZ intoxication.

having

She

She

AZ intoxication

AZ

AZ


Input: Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.

following

caffeine intoxication with coexisting hyponatremia

massive ingestion of oolong tea

oolong tea

caffeine

massive

ingestion


Input: The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.

respond

antibiotic treatment


Input: Gemfibrozil-warfarin drug interaction resulting in profound hypoprothrombinemia.

resulting

profound hypoprothrombinemia

Gemfibrozil-warfarin drug interaction

warfarin

Gemfibrozil

Gemfibrozil

warfarin


Input: Drug-induced eosinophilia is a non-dose-dependent side effect of clozapine.

induced

eosinophilia

clozapine

clozapine

non-dose-dependent


Input: Vortex keratopathy associated with atovaquone.

associated with

Vortex keratopathy

atovaquone

atovaquone


Input: DIAGNOSIS: Sustained ventricular tachycardia possibly owing to thalidomide treatment.

owing to

Sustained ventricular tachycardia

thalidomide

thalidomide


Input: In one instance a systemic hypoglycemic reaction resulting in head trauma and confusion ended in an emegency hospital admission following the substitution of acetohexamide for acetazolamide.

following

systemic hypoglycemic reaction resulting in head trauma and confusion

acetohexamide

acetohexamide

acetazolamide


Input: However, an association of Ritalin with glaucoma has been reported.

association

glaucoma

Ritalin

Ritalin


Input: After a two-month interruption of interferon administration, natural interferon alpha was given but followed by another episode of the same neurological manifestations.

followed by

neurological manifestations

interferon alpha

interferon alpha


Input: This article discusses the clinical manifestations of the serotonin syndrome and highlights reported cases of serotonin syndrome specifically related to an interaction between SSRIs and fentanyl, a commonly used opioid in anesthesia practice.

related

cases

serotonin syndrome

SSRIs and fentanyl

SSRIs

fentanyl

SSRIs

fentanyl


Input: While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.

associated

renal failure

dextran

dextran


Input: The use of pamidronate for hypercalcemia secondary to acute vitamin D intoxication.

for

pamidronate

hypercalcemia secondary to acute vitamin D intoxication

pamidronate


Input: Early overanticoagulation with acenocoumarol due to a genetic polymorphism of cytochrome P450 CYP2C9.

with

Early overanticoagulation

acenocoumarol

acenocoumarol


Input: We report an unusual pattern of supravenous hyperpigmentation occurring after CHOP chemotherapy.

after

supravenous hyperpigmentation

CHOP

CHOP


Input: Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment.

during

persistent lactate elevation

metronidazole

metronidazole


Input: Encephalopathy and seizures induced by intravesical alum irrigations.

induced

Encephalopathy and seizures

intravesical alum irrigations

alum

intravesical

irrigations


Input: Dermal side reactions to SSRI-drugs in these patients may be due to high activity in the serotonergic system at the dermal and epidermo-dermal junctional area rather than a hypersensitivity to the drug molecule itself.

to

these patients

Dermal side reactions

SSRI-drugs

SSRI


Input: CASE SUMMARY: A febrile 36-year-old seaman from Mumbai (Bombay) was prescribed >5 times the usual dose of chloroquine for malaria diagnosed empirically onboard ship.

prescribed

A febrile 36-year-old seaman from Mumbai (Bombay)

febrile

Mumbai (Bombay)

>5 times the usual dose of chloroquine

malaria

chloroquine

>5 times the usual dose


Input: MATERIALS AND METHODS: We present two cases of significant morbidity related to primary and secondary perforation of the bladder following two instillations of epirubicin.

following

two cases

two

significant morbidity related to primary and secondary perforation of the bladder

two instillations of epirubicin

instillations

epirubicin


Input: Angio-oedema as an unusual tolerable side effect of voriconazole therapy.

as

Angio-oedema

voriconazole

voriconazole


Input: Oxycodone-gabapentin reduced pain score by 33% from baseline to end of treatment.

reduced

reduced pain score by 33% from baseline

Oxycodone-gabapentin

pain

Oxycodone

gabapentin

Oxycodone

gabapentin


Input: OBJECTIVE: We report a patient who developed neutropenia on clozapine, but behind the cell count decrease showed to be a diurnal variation of the white blood cells (WBC).

developed

a patient

neutropenia

diurnal variation of the white blood cells (WBC)

clozapine

clozapine


Input: RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.

had

Five of 70 patients

Five of 70

significant weight loss

leflunomide

leflunomide


Input: Only one report links phenylpropanolamine consumption to an intracerebral hemorrhage in a patient with an AVM.

links

a patient with an AVM

AVM

intracerebral hemorrhage

phenylpropanolamine

phenylpropanolamine


Input: Anaphylactic reaction and unrelated, subsequent, known side effects during therapy with thiethylperazine.

during

Anaphylactic reaction

thiethylperazine

thiethylperazine


Input: PURPOSE: To investigate the concentration-side effect relationship in a patient with severe acyclovir-induced neurotoxicity and to summarize the information available in the literature about central nervous system side effects due to acyclovir.

induced

neurotoxicity

central nervous system side effects

acyclovir

acyclovir


Input: Radiation recall from gemcitabine is rare, but can potentially arise in any site that has been previously irradiated.

from

Radiation recall

gemcitabine

gemcitabine


Input: Most cases of pancreatitis associated with L-asparaginase toxicity are self-limiting and respond favorably to nasogastric decompression and intravenous hyperalimentation.

associated

Most cases

pancreatitis

L-asparaginase

L-asparaginase


Input: Shortly after commencing the drug, the patient developed a severe adverse drug reaction manifesting as Drug Reaction (or Rash) with Eosinophilia and Systemic Symptoms (DRESS) syndrome.

developed

the patient

severe adverse drug reaction manifesting as Drug Reaction (or Rash) with Eosinophilia and Systemic Symptoms (DRESS) syndrome

Shortly after commencing the drug

Shortly after


Input: This report presents a potential case of risperidone-induced tardive dyskinesia.

induced

a potential case

tardive dyskinesia

risperidone

risperidone


Input: The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.

after

The patient

feeling cold with worsening headache and chills

one hour after infusion of the first dose of penicillin

one hour

infusion

penicillin


Input: Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature.

associated

case

Early-onset

second-degree heart block and sinus bradycardia

pentamidine

pentamidine


Input: Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2.

associated

pulmonary fibrosis

BCNU

BCNU


Input: CONCLUSIONS: This case suggests that losartan can induce late-onset angioedema in patients with normal renal function and that the reaction can recur after initial resolution of the symptoms.

induce

patients with normal renal function

late-onset angioedema

losartan

losartan


Input: Two cases of widespread cutaneous vasculitis are described in association with diltiazem, a recently introduced calcium antagonist.

association

widespread cutaneous vasculitis

diltiazem, a recently introduced calcium antagonist

diltiazem


Input: The incidence of angioedema secondary to losartan, an angiotensin II receptor antagonist, is unknown.

secondary

angioedema

losartan, an angiotensin II receptor antagonist

losartan


Input: We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide.

developed

a young man

young

a rapid-onset short-of-breath, hemoptysis, and severe weakness

about 2 weeks after the administration of leflunomide

rheumatoid arthritis

leflunomide

2 weeks

the administration


Input: Toxicity related to chloroquine treatment of resistant vivax malaria.

related

Toxicity

chloroquine

chloroquine

resistant vivax malaria


Input: Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia.

following

Patients with vitamin B12 deficiency

vitamin B12 deficiency

neurologic deterioration

nitrous oxide anesthesia

nitrous oxide


Input: However here we reported two patients, presenting with PD during high dose colchicine treatment for familiar mediterranean fever (FMF).

during

two patients,

two

PD

high dose colchicine treatment

high dose

colchicine


Input: We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).

induced

two patients

two

infectious mononucleosis-like syndrome

salazosulfapyridine (SASP).

salazosulfapyridine


Input: Myocardial ischemia associated with high-dose carmustine infusion.

associated

Myocardial ischemia

high-dose carmustine infusion

high-dose

carmustine

infusion


Input: Hepatic drug interaction between tacrolimus and lansoprazole in a bone marrow transplant patient receiving voriconazole and harboring CYP2C19 and CYP3A5 heterozygous mutations.

between

a bone marrow transplant patient receiving voriconazole and harboring CYP2C19 and CYP3A5 heterozygous mutations

CYP2C19 and CYP3A5 heterozygous mutations

Hepatic drug interaction

tacrolimus and lansoprazole

voriconazole

bone marrow transplant

tacrolimus

lansoprazole

voriconazole

tacrolimus

lansoprazole

voriconazole


Input: Gabapentin withdrawal presenting as status epilepticus.

presenting

status epilepticus

Gabapentin withdrawal

Gabapentin


Input: Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.

induced

Atypical ventricular tachycardia (torsade de pointes)

amiodarone

amiodarone


Input: Colchicine-induced rhabdomyolysis is a rare complication, and the postulated mechanisms and risk factors for this severe complication are discussed.

induced

rhabdomyolysis

Colchicine

Colchicine


Input: Spindle coma in benzodiazepine toxicity: case report.

in

Spindle coma

benzodiazepine

benzodiazepine


Input: A typical case of dextran-40 associated acute renal failure is presented.

associated

acute renal failure


Input: After the second infliximab infusion, he was found to have a severe transient neutropenia (0.5 x 10(9)/L).

found

he

he

severe transient neutropenia (0.5 x 10(9)/L)

infliximab

infliximab

infusion


Input: Lithium for irritability in post-traumatic stress disorder.

for

Lithium

irritability in post-traumatic stress disorder

Lithium


Input: Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis.

due

Iatrogenic hypercalcemia

vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics

psoriasis

vitamin D3

thiazide diuretics

ointment

vitamin D3

thiazide diuretics


Input: A case of mania associated with fluoxetine.

associated

A case

mania

fluoxetine

fluoxetine


Input: RESULTS: Extensive squamous metaplasia was found in endometrial glands following progestin therapy.

following

Extensive squamous metaplasia was found in endometrial glands

progestin therapy

progestin


Input: Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test.

caused

Acute generalized exanthematous pustulosis

morphine

morphine


Input: Eleven days after initiation of therapy with amiodarone, the patient experienced syncope and was noted to have recurrent episodes of polymorphous ventricular tachycardia.

experienced

the patient

syncope and was noted to have recurrent episodes of polymorphous ventricular tachycardia

Eleven days after initiation of therapy with amiodarone

Eleven days after

amiodarone


Input: Prolonged used of hydroxyurea in patients with ET may lead to therapy-associated acute leukemia.

associated

patients with ET

therapy-associated acute leukemia

hydroxyurea

hydroxyurea

ET

Prolonged used


Input: Metastatic osteomyelitis following BCG vaccination.

following

Metastatic osteomyelitis

BCG vaccination

BCG vaccination


Input: Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.

induced

coma

Carbamyl phosphate synthetase-1 deficiency

valproic acid

valproic acid


Input: We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature, emphasizing the risk factors associated with this manifestation.

of

two patients

two

painful erosions of their psoriasis

methotrexate

psoriasis

methotrexate


Input: Methysergide-induced retroperitoneal fibrosis: successful outcome and two new laboratory features.

induced

retroperitoneal fibrosis

Methysergide

Methysergide


Input: We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.

suffered

2 children with cerebral palsy

children

significant morbidity immediately

treatment with hyperbaric oxygen

cerebral palsy

hyperbaric oxygen


Input: A patient is described with polycythemia vera who was taking anticoagulants and developed a spontaneous retropharyngeal hemorrhage after a violent sneezing episode.

developed

A patient

polycythemia vera

a spontaneous retropharyngeal hemorrhage after a violent sneezing episode

anticoagulants

anticoagulants


Input: CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections are the major side effects of fludarabine phosphate therapy.

of

CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections

fludarabine phosphate

fludarabine phosphate


Input: Penicillin-induced Jarisch-Herxheimer reaction.

induced

Jarisch-Herxheimer reaction

Penicillin

Penicillin


Input: The authors suggest that risperidone may increase affect in patients with schizophrenia and that some patients, especially those with anxiety, may have difficulty managing the increase.

increase

patients with schizophrenia

increase affect

risperidone

risperidone

schizophrenia


Input: We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.

due

a patient with progressive renal impairment

progressive renal impairment

blurred vision, QRS broadening and cardiac failure

chronic cibenzoline intoxication

cibenzoline

intoxication

chronic


Input: In a postoperative patient with pre-existent myasthenia gravis, oral verapamil caused a marked exacerbation in myasthenic weakness.

caused

a postoperative patient with pre-existent myasthenia gravis

pre-existent myasthenia gravis

marked exacerbation in myasthenic weakness

oral verapamil

oral

verapamil


Input: An objective causality assessment suggests that the JHR in our patient was probably related to penicillin.

related

patient

JHR

penicillin

penicillin


Input: RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.

after

A 34-year-old man

man

visual field defects and severe vision loss in both eyes

intravitreal injection of triamcinolone

diabetic macular edema

intravitreal injection

triamcinolone


Input: Simvastatin-amiodarone interaction resulting in rhabdomyolysis, azotemia, and possible hepatotoxicity.

resulting

rhabdomyolysis, azotemia, and possible hepatotoxicity

Simvastatin-amiodarone interaction

amiodarone

Simvastatin

amiodarone

Simvastatin


Input: A 73-year-old woman receiving high-dosage olanzapine for bipolar disorder developed parkinsonism after smoking cessation.

after

A 73-year-old woman

woman

parkinsonism

high-dosage olanzapine

smoking cessation

bipolar disorder

olanzapine

smoking

high-dosage


Input: Fatal pulmonary fibrosis induced by paclitaxel: a case report and review of the literature.

induced

pulmonary fibrosis

paclitaxel

paclitaxel


Input: Raltegravir-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome - implications for clinical practice and patient safety.

induced

Eosinophilia and Systemic Symptoms (DRESS) syndrome

Raltegravir

Raltegravir


Input: A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.

develop

10-year-old boy with osteosarcoma and normal renal function

boy

impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase

acute renal failure with life-threatening hyperkalemia 29 hours later

4-hour infusion of high-dose methotrexate (MTX) (12 g/m2)

within 2 hours

29 hours later

infusion

methotrexate

high-dose

12 g/m2

osteosarcoma


Input: Transient trazodone-induced hypomanic symptoms occurred in three depressed patients.

induced

three depressed patients

three

hypomanic symptoms

trazodone

depressed

trazodone


Input: We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.

induced

a case

disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci)

praziquantel therapy

praziquantel


Input: Drug-induced fever should be considered in patients who have unexplained high temperatures during diltiazem therapy.

induced

fever

unexplained high temperatures

diltiazem therapy

diltiazem


Input: Hemodialysis was also shown to reverse ifosfamide-related neurotoxicity.

related

neurotoxicity

ifosfamide

ifosfamide


Input: Palpable purpuric skin lesions on the anterior surface of both legs appeared on the 55th day of amphotericin B treatment.

appeared

Palpable purpuric skin lesions on the anterior surface of both legs

55th day of amphotericin B treatment

55th day

amphotericin B


Input: Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.

following

Transient left homonymous hemianopsia and encephalopathy

cisplatinum, vinblastine, and bleomycin

testicular carcinoma

cisplatinum

vinblastine

bleomycin

cisplatinum

vinblastine

bleomycin


Input: We report a 46-yr-old woman with ovarian carcinoma who developed porphyria cutanea tarda while undergoing treatment with cisplatin and cyclophosphamide.

developed

a 46-yr-old woman with ovarian carcinoma

woman

porphyria cutanea tarda

cisplatin and cyclophosphamide

cisplatin

cyclophosphamide

ovarian carcinoma

cisplatin

cyclophosphamide


Input: In one child, a second course of carbamazepine resulted in a return of the dystonia.

resulted

one child

one

child

a return of the dystonia

a second course of carbamazepine

second course

carbamazepine


Input: Does acyclovir increase serum lithium levels?

increase

serum lithium levels

acyclovir

lithium

acyclovir

lithium

acyclovir

lithium


Input: Sulfadiazine crystalluria revisited.

revisited.

crystalluria

Sulfadiazine

Sulfadiazine


Input: Administration of sumatriptan in subarachnoid haemorrhage (SAH) patients, misdiagnosed as migraine patients, may induce symptomatic cerebral vasospasm with potentially dangerous consequences.

induce

patients

symptomatic cerebral vasospasm

sumatriptan

subarachnoid haemorrhage

sumatriptan


Input: Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.

development

Six of 13 outpatients with schizophrenia

Six of 13

intolerable affect, including feelings of agitation and depression and periods of crying and insomnia

a ten-week open trial of risperidone

risperidone

a ten-week

schizophrenia


Input: Pulmonary edema during acute infusion of epoprostenol in a patient with pulmonary hypertension and limited scleroderma.

during

a patient with pulmonary hypertension and limited scleroderma

acute infusion of epoprostenol

epoprostenol

acute infusion

pulmonary hypertension and limited scleroderma


Input: Recent reports have shown that Decadron (dexamethasone; Merck Sharp & Dohme, West Point, Pa) has a significant antiemetic effect on cisplatin-induced vomiting.

antiemetic

Decadron

cisplatin-induced vomiting

Decadron


Input: Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.

after

Pleuropulmonary fibrosis

long-term treatment with the dopamine agonist pergolide

pergolide

Parkinson Disease


Input: An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.

after

An infertile patient with amenorrhea-galactorrhea syndrome

infertile

lost vision

Bromocryptine

Bromocryptine

amenorrhea-galactorrhea syndrome


Input: CONCLUSIONS: The observation that neurotoxicity developed with a delay of 24 to 48 hours after acyclovir peak serum concentrations could explain the wide range of acyclovir levels reported in similar cases.

developed

neurotoxicity

acyclovir

24 to 48 hours after

acyclovir


Input: Two cases of mequitazine-induced photosensitivity reactions.

induced

photosensitivity reactions

mequitazine

mequitazine


Input: Rhabdomyolysis associated with clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes.

with

a patient with decreased calcium-dependent potassium permeability of cell membranes

decreased calcium-dependent potassium permeability of cell membranes

Rhabdomyolysis

clozapine

clozapine


Input: A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities, developed gradual stiffness and weakness of the lower extremities.

developed

A 47 year-old woman

47 year-old

woman

gradual stiffness and weakness of the lower extremities

a 4-year history of intramuscular pentazocine injections in the lower extremities

intramuscular

injections

pentazocine


Input: The possibility of severe rhabdomyolysis should be considered in a patient with water intoxication due to massive ingestion of caffeine-containing beverages.

due to

a patient

severe rhabdomyolysis

water intoxication

massive ingestion of caffeine-containing beverages

caffeine

ingestion

massive


Input: CASE SUMMARY: A 25-year-old postpartum white woman developed multiple watery stools and abdominal cramping on day 6 of therapy with clindamycin vaginal cream for bacterial vaginosis.

developed

A 25-year-old postpartum white woman

postpartum

white

woman

multiple watery stools and abdominal cramping

clindamycin vaginal cream for bacterial vaginosis

bacterial vaginosis

vaginal cream

clindamycin

day 6


Input: Dose-dependent olanzapine-associated leukopenia: three case reports.

associated

three case

three

leukopenia

olanzapine

olanzapine


Input: He became completely premorbid 2 weeks after administration of levodopa.

after

He

He

premorbid

levodopa

levodopa

2 weeks


Input: The authors describe a case of interstitial granulomatous dermatitis associated with darifenacin.

associated

interstitial granulomatous dermatitis

darifenacin

darifenacin


Input: Amiodarone was the third drug to induce AVT in this patient; she received 200 mg/day six days per week for six months.

induce

patient

she

she

AVT

Amiodarone

200 mg/day six days per week for six months

Amiodarone

200 mg/day

six days per week

six months


Input: A young diamond dealer developed visual impairment attributed to bilateral posterior subcapsular cataracts following only four courses of intermittent Decadron used as part of a five-drug antiemetic regimen for cisplatin-associated nausea.

following

A young diamond dealer

young

visual impairment attributed to bilateral posterior subcapsular cataracts

only four courses of intermittent Decadron used as part of a five-drug antiemetic regimen

cisplatin-associated nausea

Decadron

five-drug antiemetic regimen

four courses

Decadron

five-drug antiemetic regimen


Input: OBJECTIVE: To report a case of angioedema associated with losartan administration.

associated

a case

angioedema

losartan administration

losartan


Input: The authors present a case report of a granulomatous reaction leading to urethral prolapse, 3 months after the transurethral injection of calcium hydroxylapatite.

leading

a case report

granulomatous reaction

urethral prolapse

3 months after the transurethral injection of calcium hydroxylapatite

3 months

transurethral injection

calcium hydroxylapatite


Input: Epstein-Barr virus-associated lymphoproliferative disorder in a patient with rheumatoid arthritis on methotrexate and rofecoxib: idiosyncratic reaction or pharmacogenetics?

in

a patient with rheumatoid arthritis

Epstein-Barr virus-associated lymphoproliferative disorder

methotrexate and rofecoxib

rheumatoid arthritis

methotrexate

rofecoxib


Input: On the other hand, aspirin may have promoted the enlargement of spontaneous hemorrhage from meningioma.

promoted

enlargement of spontaneous hemorrhage from meningioma

aspirin

aspirin


Input: The two groups did not differ significantly in the rate of serious adverse events, though the risk of diarrhea was increased with omeprazole.

increased

risk of diarrhea was increased

omeprazole

omeprazole


Input: Treatment of a patient with severe digitoxin intoxication by Fab fragments of anti-digitalis antibodies.

Treatment

a patient with severe digitoxin intoxication

Fab fragments of anti-digitalis antibodies

digitoxin intoxication

Fab fragments of anti-digitalis antibodies


Input: Development of porphyria cutanea tarda after treatment with cyclophosphamide.

after

porphyria cutanea tarda

cyclophosphamide

cyclophosphamide.


Input: We report a premature infant who developed seizures associated with intraventricular administration of nafcillin and discuss the need for electroencephalographic monitoring of patients receiving intraventricular antibiotics.

associated with

a premature infant

infant

premature

seizures

intraventricular administration of nafcillin

nafcillin

intraventricular


Input: OBJECTIVE: To present a single case of zuclopenthixol-induced priapism and a literature review.

induced

priapism

zuclopenthixol

zuclopenthixol


Input: CASE REPORT: We hereby report a case of radiation recall dermatitis and myositis occurring on gemcitabine monotherapy, five months after completing chemoradiation for locally advanced pancreatic cancer.

occurring

radiation recall dermatitis and myositis

gemcitabine monotherapy, five months after completing chemoradiation

gemcitabine

locally advanced pancreatic cancer

five months after


Input: Stroke-like syndrome after gold sodium thiomalate induced vasomotor reaction.

after

vasomotor reaction

Stroke-like syndrome

gold sodium thiomalate

gold sodium thiomalate


Input: MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis.

induced

hepatic injury and liver enzyme elevations

MTX

MTX


Input: An adverse drug reaction (ADR) induced by fluoxetine was suspected and fluoxetine treatment was discontinued.

induced

An adverse drug reaction (ADR)

fluoxetine

fluoxetine

fluoxetine


Input: New onset of Crohn's disease during treatment of active ankylosing spondylitis with etanercept.

during

New onset of Crohn's disease

etanercept

etanercept

active ankylosing spondylitis


Input: Fatal hepatitis after long-term pulse itraconazole treatment for onychomycosis.

after

Fatal hepatitis

long-term pulse itraconazole treatment

itraconazole

long-term

pulse

onychomycosis


Input: Fatal outcome of intravesical formalin instillation, with changes mimicking renal tuberculosis.

of

with changes mimicking renal tuberculosis

Fatal outcome

intravesical formalin instillation

formalin

intravesical

instillation


Input: Both reactions were caused due to this anti-emetic drug, but an additive effect of clemastine fumarate, prescribed to treat the anaphylactic reaction, is suggested by the sequence of events.

suggested

additive effect

clemastine fumarate

anaphylactic reaction

clemastine fumarate


Input: Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine.

treated

cyclosporine

cyclosporine

systemic lupus erythematosus with thrombocytopenia


Input: Among patients receiving aspirin and clopidogrel, prophylactic use of a PPI reduced the rate of upper gastrointestinal bleeding.

prophylactic use

patients receiving aspirin and clopidogrel

reduced the rate of upper gastrointestinal bleeding

PPI

aspirin

clopidogrel

PPI

aspirin

clopidogrel

PPI


Input: Clofazimine enteropathy in a pediatric bone marrow transplant recipient.

in

a pediatric bone marrow transplant recipient

enteropathy

Clofazimine

Clofazimine


Input: Anisocoria from transdermal scopolamine.

from

Anisocoria

transdermal scopolamine

transdermal scopolamine


Input: His fever resolved, but he developed symptoms consistent with those of chloroquine toxicity.

developed

he

he

symptoms consistent with those of chloroquine toxicity

chloroquine

chloroquine


Input: A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.

developed

A 36-year-old man

testicular carcinoma

man

dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome

cisplatinum, vinblastine, and bleomycin

testicular carcinoma

cisplatinum

vinblastine

bleomycin

cisplatinum

vinblastine

bleomycin


Input: We report the first death associated with rhabdomyolysis in a patient treated with a statin and a protease inhibitor, which produced a significant drug-drug interaction.

treated

a patient

death associated with rhabdomyolysis

a statin and a protease inhibitor

statin

protease inhibitor

statin

protease inhibitor


Input: Methotrexate (MTX) is a commonly used second line agent for RA, and there have been several recent reports of Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder in MTX-treated RA patients.

reports

RA patients

Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder

MTX-treated

MTX

RA


Input: To describe a case of azathioprine-induced warfarin resistance, present a literature review on warfarin-azathioprine interactions, and provide recommendations on appropriate management of this clinically significant interaction.

induced

warfarin resistance

azathioprine

azathioprine


Input: Pulmonary fibrosis is a complication of paclitaxel therapy that may occur despite treatments with corticosteroids.

complication

Pulmonary fibrosis

paclitaxel therapy

paclitaxel


Input: Two patients with adrenal carcinoma treated with 2,2-bis (2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane (o,p'-DDD) as adjuvant therapy were studied.

treated

Two patients with adrenal carcinoma

Two

2,2-bis (2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane (o,p'-DDD) as adjuvant therapy

2,2-bis (2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane

adrenal carcinoma


Input: METHODS: Repeated blood samples were drawn in a patient with severe acyclovir overdose who developed coma and nonoliguric renal failure.

developed

a patient

coma and nonoliguric renal failure

acyclovir overdose

overdose

acyclovir


Input: An 8-year-old girl, who had been vaccinated with BCG without subsequent regional reactions, developed osteomyelitis in the left calcaneus 7 months later.

developed

8-year-old girl

girl

osteomyelitis

BCG

BCG


Input: Since this amount of FAB was insufficient to bind all DGTX present in the serum, cardiac DGTX toxicity (total AV-block) persisted.

persisted.

cardiac DGTX toxicity (total AV-block)

DGTX

DGTX

FAB


Input: Abnormalities of the pupil and visual-evoked potential in quinine amblyopia.

in

amblyopia

Abnormalities of the pupil and visual-evoked potential

quinine

quinine


Input: A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy.

resulted

severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration

magnesium sulfate

toxemia of pregnancy

magnesium sulfate


Input: Concurrent acute megaloblastic anaemia and pneumonitis: a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis.

of

Concurrent acute megaloblastic anaemia and pneumonitis

low-dose methotrexate

rheumatoid arthritis

low-dose

methotrexate


Input: Patients should be informed about the risk of osteonecrosis when taking dexamethasone as an antiemetic drug.

risk

Patients

osteonecrosis

dexamethasone

dexamethasone


Input: We report a patient with inoperable pancreatic cancer who developed gastrointestinal bleeding secondary to radiation-recall related to gemcitabine and review literature.

developed

a patient with inoperable pancreatic cancer

gastrointestinal bleeding

radiation-recall

gemcitabine

inoperable pancreatic cancer

gemcitabine


Input: We report a case of SJS in a 14-year-old male with nephrotic syndrome, who was treated with oral prednisolone for 6 weeks.

with

a 14-year-old male

male

SJS

oral prednisolone for 6 weeks

oral

prednisolone

6 weeks


Input: A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil.

developed

A 45-year-old woman with thyrotoxicosis

woman

agranulocytosis

propylthiouracil

thyrotoxicosis

propylthiouracil


Input: We wish to call for cautious approach at time of cessation of prolonged ACTH therapy because of possible unexpected and only partially understood hazardous side effects such as hyperkalemia.

of

hyperkalemia

cessation of prolonged ACTH

ACTH


Input: Haemolytic-uraemic syndrome complicating long-term mitomycin C and 5-fluorouracil therapy for gastric carcinoma.

complicating

Haemolytic-uraemic syndrome

long-term mitomycin C and 5-fluorouracil therapy

gastric carcinoma

mitomycin C

mitomycin C


Input: Although this article focuses on serotonin syndrome as a result of an adverse interaction of selective serotonin reuptake inhibitors (SSRI) and fentanyl, it is important for not only anesthesia professionals, but all clinicians--such as those in emergency medicine and critical care--to be aware of this syndrome and its management.

result

serotonin syndrome

selective serotonin reuptake inhibitors

fentanyl

selective serotonin reuptake inhibitors (SSRI)

fentanyl

selective serotonin reuptake inhibitors (SSRI)

fentanyl


Input: Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.

associated

a 61-year-old diabetic patient who presented wit hypoglycaemic coma

hypoglycaemic coma

Intrahepatic cholestasis and cutaneous bullae

glibenclamide

glibenclamide

diabetic


Input: In the presented case, the temporal relationship between the administration of cloxacillin and increased INR suggests that the cloxacillin was responsible for the enhanced warfarin activity.

administration

case

enhanced warfarin activity.

increased INR

cloxacillin

cloxacillin

warfarin

warfarin

cloxacillin


Input: Cardiac arrest following use of sumatriptan.

following

Cardiac arrest

sumatriptan

sumatriptan


Input: We report four cases of encephalopathy coincident with elevated aluminum levels as well as one patient who developed seizures while receiving continuous bladder irrigations with alum.

developed

one patient

one

seizures

receiving continuous bladder irrigations with alum

alum


Input: Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.

associated

Nine azotemic patients

Nine

azotemic

coagulopathy

cephalosporin or moxalactam antibiotics

cephalosporin

moxalactam


Input: This report suggests that the poor prognosis previously given to fetuses exposed to disulfiram in the first trimester may not be warranted.

exposed

fetuses

fetuses

poor prognosis

disulfiram

disulfiram


Input: We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.

injured

muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis

caffeine toxicity

caffeine


Input: The aim of this paper is to report the case of rosaceiform eruption induced by erlotinib in an 81-year-old-man and to discuss the pathogenetic role of Demodex folliculorum mites, found in the present patient, using skin scraping.

induced

an 81-year-old-man

man

rosaceiform eruption

Demodex folliculorum mites

erlotinib

skin scraping

erlotinib


Input: An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.

developed

An 11-year-old boy

graft-versus-host disease

boy

severe enteropathy

clofazimine treatment

2 years

clofazimine

graft-versus-host disease


Input: The authors conclude that among patients taking high doses of oral niacin only those who experience visual symptoms need to be ophthalmologically evaluated.

taking

patients

visual symptoms

high doses of oral niacin

high doses

oral

niacin


Input: Reflex sympathetic dystrophy syndrome in renal transplanted patients under immunosuppression with tacrolimus.

with

renal transplanted patients

renal transplanted

Reflex sympathetic dystrophy syndrome

tacrolimus

tacrolimus


Input: We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).

presented

an 11-year-old female treated for mediastinal T-cell lymphoma

female

renal failure

following the second cycle of high-dose methotrexate (HDMTX)

methotrexate (HDMTX)

second cycle

high-dose

mediastinal T-cell lymphoma


Input: We report three cases of patients who developed leukopenia during olanzapine treatment.

developed

three cases of patients

three

leukopenia

olanzapine treatment

olanzapine


Input: Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine.

associated with

Rapid onset of muscle weakness (rhabdomyolysis)

the combined use of simvastatin and colchicine

simvastatin

colchicine

simvastatin

colchicine


Input: A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac.

during

A 35-year-old man with seropositive rheumatoid arthritis

man

selective IgA deficiency

fenclofenac

fenclofenac

seropositive rheumatoid arthritis


Input: In this report, two newborns with congenital heart anomalies demonstrated the harlequin color change, one whose skin findings showed a course related to the dose of systemic prostaglandin E1, suggesting a possible association.

related

two newborns with congenital heart anomalies

two

newborns

harlequin color change

prostaglandin E1

congenital heart anomalies

prostaglandin E1


Input: Nonspecific but significant abnormalities have been described in the infants of women treated with disulfiram in the first trimester of their pregnancies.

treated

infants

infants

abnormalities

disulfiram

disulfiram


Input: These data indicated that infliximab possibly triggered production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis.

triggered

production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis

infliximab

infliximab


Input: Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report.

under

a postmenopausal woman

postmenopausal

woman

Ovarian endometrioid adenocarcinoma

tamoxifen therapy

tamoxifen

breast cancer


Input: Tacrolimus-induced HUS: an unusual cause of acute renal failure in nephrotic syndrome.

induced

HUS

Tacrolimus

Tacrolimus

nephrotic syndrome


Input: OBJECTIVE: To report the clinical course of a woman with cryptococcal meningitis and no previous cardiac disease who developed a fatal cardiac arrhythmia after an acute overdose of amphotericin B and to review its toxicity.

developed

a woman with cryptococcal meningitis and no previous cardiac disease

woman

a fatal cardiac arrhythmia

an acute overdose of amphotericin B

cryptococcal meningitis

amphotericin B

overdose


Input: We report a case of a bullous lichenoid eruption due to the intake of captopril.

due

a case

bullous lichenoid eruption

captopril

captopril


Input: The hypoadrenalism was overcome by increasing steroid replacement therapy.

overcome

increasing steroid replacement therapy

The hypoadrenalism

steroid

increasing


Input: DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.

induced

cardiomyopathy

Interferon alpha-2b

Interferon alpha-2b


Input: Choroidal hemorrhage associated with systemic tissue plasminogen activator.

associated

Choroidal hemorrhage

systemic tissue plasminogen activator

systemic tissue plasminogen activator


Input: Clozapine-induced eosinophilia and switch to quetiapine in a patient with chronic schizophrenia with suicidal tendencies.

induced

a patient with chronic schizophrenia with suicidal tendencies

eosinophilia

Clozapine

chronic schizophrenia with suicidal tendencies

Clozapine


Input: Adverse effects of propafenone after long-term therapy with the addition of citalopram.

after

Adverse effects

long-term therapy with the addition of citalopram

propafenone

citalopram

long-term

citalopram

propafenone


Input: The case of an adult who developed both hepatic dysfunction and an impaired macrophage migration after exposure to cimetidine is discussed.

developed

an adult

adult

hepatic dysfunction and an impaired macrophage migration

cimetidine is discussed

cimetidine


Input: We report 4 patients who developed symptoms of myasthenia gravis within 2 weeks of starting treatment with a statin drug.

developed

4 patients

symptoms of myasthenia gravis

within 2 weeks of starting treatment with a statin

statin

2 weeks


Input: After only the third dose of pentamidine, it was noted that the patient's heart rate had decreased to 48 beats/minute.

After

patient's

heart rate had decreased to 48 beats/minute

third dose of pentamidine

third dose

pentamidine


Input: A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).

induced

A 44-year-old woman

woman

atypical ventricular tachycardia (AVT, torsade de pointes)

amiodarone, disopyramide, and quinidine

amiodarone

disopyramide

quinidine


Input: Azathioprine was the probable causative agent of warfarin resistance according to the Naranjo probability scale, and a possible causative agent according to the Drug Interaction Probability Scale.

causative agent

warfarin resistance

Azathioprine

Azathioprine


Input: Disulfiram has been used effectively to deter alcohol consumption in patients with a history of alcohol abuse.

used

patients with a history of alcohol abuse

Disulfiram

Disulfiram

history of alcohol abuse


Input: Nevirapine is a non-nucleoside reverse transcriptase inhibitor used in the treatment of human immunodeficiency virus (HIV)-infected patients and in post-exposure prophylaxis.

treatment

human immunodeficiency virus (HIV)-infected patients

Nevirapine

Nevirapine

immunodeficiency virus


Input: Vasospasm associated with ergotamine is a well-known phenomenon.

associated

Vasospasm

ergotamine

ergotamine


Input: After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.

developed

loss of glomerular filtration rate and effective renal plasma flow

After a six-week course of low-dose cyclosporine A

low-dose

cyclosporine A

six-week course


Input: We report a case of severe simvastatin-induced rhabdomyolysis triggered by the addition of amiodarone to previously well-tolerated chronic statin therapy.

induced

rhabdomyolysis

simvastatin

the addition of amiodarone to previously well-tolerated chronic statin therapy

simvastatin

amiodarone

statin

chronic

amiodarone

simvastatin


Input: In January 2010, a 50-year-old transgender female with HIV infection and recurrent deep vein thrombosis began treatment with the TRIO study regimen.

treatment

a 50-year-old transgender female

transgender female

TRIO

TRIO

HIV infection and recurrent deep vein thrombosis


Input: In vitro inhibition of CYP2C9 by zafirlukast is consistent with clinical studies showing impaired clearance of  S-warfarin and enhanced anti-thrombotic effects, although the in vitro IC(50) value is higher than the usual range of clinically relevant plasma concentrations.

showing

impaired clearance of  S-warfarin and enhanced anti-thrombotic effects

zafirlukast

zafirlukast


Input: Although it is difficult to solely attribute intratumoral hemorrhage to aspirin, we have to be careful when prescribing aspirin for patients who have asymptomatic meningioma.

attribute

patients who have asymptomatic meningioma

intratumoral hemorrhage

aspirin

aspirin

asymptomatic meningioma


Input: CONCLUSIONS: The fundus picture shown in these cases may be typical of ASPPC after IVTA injection.

after

ASPPC

IVTA injection

IVTA

injection


Input: The probable proarrhythmic action of amiodarone, although rare, is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy.

action

proarrhythmic

amiodarone

amiodarone


Input: We present two cases of severe, atypical ASRs which occurred during NMSC treatment with imiquimod in the context of infliximab administration for psoriasis, and consider the grounds supporting a non-fortuitous association.

occurred

atypical ASRs

imiquimod in the context of infliximab administration

NMSC

psoriasis

NMSC

imiquimod

infliximab

imiquimod

infliximab


Input: A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented.

complicated

esophageal spasm preventing extrication of an orogastric lavage tube

propranolol overdose

propranolol

overdose


Input: Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis.

induced

selective IgA deficiency in rheumatoid arthritis

Fenclofenac

Fenclofenac


Input: Naproxen, the most common offender, has been associated with a dimorphic clinical pattern: a PCT-like presentation and one simulating erythropoietic protoporphyria in the pediatric population.

associated

pediatric population

pediatric

erythropoietic protoporphyria

Naproxen

Naproxen


Input: Zafirlukast is a cysteinyl leukotriene antagonist used to treat allergic and exercise-induced asthma.

treat

Zafirlukast is a cysteinyl leukotriene antagonist

allergic and exercise-induced asthma

Zafirlukast


Input: Rapidly developing hyperglycemia during treatment with olanzapine.

during

Rapidly developing hyperglycemia

olanzapine

olanzapine


Input: The first patient was a 61-year-old man with a 30-year history of fistulizing CD in whom B-cell non-Hodgkin's lymphoma was diagnosed 9 months after treatment with infliximab.

diagnosed

The first patient was a 61-year-old man with a 30-year history of fistulizing CD

man

B-cell non-Hodgkin's lymphoma

9 months after treatment with infliximab

fistulizing CD

9 months

infliximab


Input: Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide.

treated

pediatric oncology patients

pediatric

drug-induced Fanconi syndrome

ifosfamide

oncology

ifosfamide


Input: We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field.

developed

a patient with chronic renal failure and ischemic heart disease

clinically significant methemoglobinemia

an axillary block with bupivacaine and additional injection of lidocaine in the operative field

chronic renal failure and ischemic heart disease

bupivacaine

lidocaine

injection

bupivacaine

lidocaine


Input: Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemia.

induced

type 5 Bartter-like syndrome with severe hypocalcemia

Amikacin

Amikacin


Input: L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.

treated

percutaneous drainage

L-asparaginase-induced severe necrotizing pancreatitis


Input: This report describes the first case of insulin-induced cardiac failure in a patient without underlying heart disease.

induced

a patient without underlying heart disease

cardiac failure

insulin

insulin


Input: OBJECTIVE: To determine the frequency of weight loss in patients treated with leflunomide for rheumatoid arthritis at an arthritis referral center.

loss

patients

weight loss

leflunomide

rheumatoid arthritis

leflunomide


Input: INH, which is a leading cause of drug eruptions in the above group of drugs was withdrawn.

a leading cause

drug eruptions

INH

INH


Input: Complications associated with primary and secondary perforation of the bladder following immediate instillations of epirubicin after transurethral resection of superficial urothelial tumours.

following

Complications associated with primary and secondary perforation of the bladder

instillations of epirubicin

epirubicin

instillations


Input: Ofloxacin: a probable cause of toxic epidermal necrolysis.

cause

toxic epidermal necrolysis

Ofloxacin

Ofloxacin


Input: Fatal lung fibrosis caused by paclitaxel toxicity has not been reported In this report, we describe the case of a 62-year-old woman who received six cycles of paclitaxel and carboplatin as combination chemotherapy for advanced ovarian cancer.

received

62-year-old woman

advanced ovarian cancer

woman

Fatal lung fibrosis

six cycles of paclitaxel and carboplatin as combination chemotherapy

six cycles

paclitaxel

carboplatin

advanced ovarian cancer

chemotherapy

paclitaxel

carboplatin


Input: A 21-year-old patient developed rhabdomyolysis during his nineteenth week of treatment with clozapine for drug-resistant schizophrenia.

developed

A 21-year-old patient

rhabdomyolysis

during his nineteenth week of treatment with clozapine

drug-resistant schizophrenia

clozapine

during his nineteenth week


Input: Cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with neuroendocrine tumor of the cervix: a case report and review of the literature.

induced

a patient with neuroendocrine tumor of the cervix

syndrome of inappropriate antidiuretic hormone (SIADH)

Cisplatin

Cisplatin

neuroendocrine tumor of the cervix


Input: Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion.

associated

Myoglobinuria and acute renal failure

intravenous vasopressin infusion

intravenous

infusion

vasopressin


Input: We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.

associated

adult respiratory distress syndrome (ARDS)

pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin

pegylated interferon alpha-2a

ribavirin

hepatitis C


Input: Catatonia associated with disulfiram therapy.

associated

Catatonia

disulfiram therapy

disulfiram


Input: To date, no relation has ever been suggested between TNF-alpha inhibitors and increased susceptibility to developing exaggerated ASRs with imiquimod.

developing

exaggerated ASRs

TNF-alpha inhibitors

imiquimod

TNF-alpha inhibitors

imiquimod

TNF-alpha inhibitors

imiquimod


Input: Losartan-induced angioedema.

induced

angioedema

Losartan

Losartan


Input: However, dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine-derivative drugs.

induced

photosensitivity

mequitazine

mequitazine


Input: Oxycodone-gabapentin also significantly improved pain relief vs gabapentin alone (P = 0.003).

improved

Oxycodone-gabapentin

pain

Oxycodone

gabapentin

Oxycodone

gabapentin


Input: In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the incontinence.

contributed

the patients

incontinence

lithium carbonate and beta-blockers

lithium carbonate

beta-blockers

beta-blockers

lithium carbonate


Input: Pulmonary fibrosis is a severe complication associated with bis-chloronitrosourea (BCNU) therapy.

associated

Pulmonary fibrosis is a severe complication

bis-chloronitrosourea (BCNU) therapy

bis-chloronitrosourea


Input: We report here a 26-year-old female with diffuse large B-cell lymphoma who died of severe pulmonary fibrosis 81 days after the administration of high-dose BCNU (600 mg/m2).

administration

26-year-old female with diffuse large B-cell lymphoma

female

died of severe pulmonary fibrosis

high-dose BCNU (600 mg/m2)

BCNU

600 mg/m2

81 days after

diffuse large B-cell lymphoma


Input: The patient was given methimazole instead of propylthiouracil but, 10 weeks later, agranulocytosis again occurred.

occurred.

The patient

agranulocytosis

methimazole

methimazole

propylthiouracil

10 weeks later


Input: Three months after starting citalopram, she experienced episodes of chest tightness and dizziness.

experienced

she

she

chest tightness and dizziness

citalopram

citalopram

Three months


Input: Although differential diagnostic alternatives can be considered in all described cases it is very likely that vincristine does cause severe visual loss in a small number of patients.

cause

a small number of patients

a small number

severe visual loss

vincristine

vincristine


Input: This case is remarkable since 1) ECM developed after subcutaneous and not after intramuscular injection, 2) the injection was given by the patient himself, and 3) glatiramer acetate can induce skin necrosis as a side effect.

induce

skin necrosis

glatiramer acetate

glatiramer acetate


Input: SSRI-drugs increase serotonin concentrations and are known to have pruritus and other dermal side effects.

increase

increase serotonin concentrations

pruritus and other dermal side effects.

SSRI-drugs

SSRI


Input: Dabigatran etexilate and concomitant use of non-steroidal anti-inflammatory drugs or acetylsalicylic acid in patients undergoing total hip and total knee arthroplasty: no increased risk of bleeding.

in

patients undergoing total hip and total knee arthroplasty

no increased risk of bleeding

Dabigatran etexilate and concomitant use of non-steroidal anti-inflammatory drugs or acetylsalicylic acid

Dabigatran etexilate

non-steroidal anti-inflammatory drugs

acetylsalicylic acid

total hip and total knee arthroplasty

non-steroidal anti-inflammatory drugs

acetylsalicylic acid

Dabigatran etexilate


Input: Our literature review revealed an additional six cases of onset of inflammatory arthritis in MS patients receiving IFN-beta.

onset

six cases

in MS patients

six

inflammatory arthritis

receiving IFN-beta

IFN-beta

MS


Input: Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day, AVT with syncope occurred; isoproterenol abolished the arrhythmia instantly.

occurred;

AVT with syncope

Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day

24 hours

300 to 600 mg/day

disopyramide

Two years


Input: The patient was initially treated with hydration and furosemide but developed congestive heart failure.

developed

The patient

congestive heart failure

furosemide

furosemide


Input: We present an interesting case of an HIV-positive woman on antiretroviral therapy having tubal pregnancies on two separate occasions with Implanon in place.

having

an HIV-positive woman

woman

tubal pregnancies

antiretroviral

HIV-positive

antiretroviral

Implanon


Input: We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.

resulted

enhanced hematopoietic toxicity and immunosuppression

causing the EBV-associated lymphoproliferative disease

MTX

MTX


Input: Temsirolimus-induced glomerulopathy.

induced

glomerulopathy

Temsirolimus

Temsirolimus


Input: OBJECTIVE: To report a case of linear immunoglobulin (Ig) A bullous dermatosis (LABD) induced by gemcitabine.

induced

a case

linear immunoglobulin (Ig) A bullous dermatosis (LABD)

gemcitabine

gemcitabine


Input: This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue.

developed

patient

sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness

the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue

5 days after the second course

MTX

leucovorin rescue

8 gm/m2 by 6 h continuous

infusion

leucovorin rescue

MTX


Input: Adult and adolescent patients (> or = 12 years old; n = 141) with severe, persistent, oral steroid (prednisone)-dependent asthma.

dependent

Adult and adolescent patients

Adult and adolescent

asthma

oral steroid (prednisone)

oral

steroid

prednisone)


Input: DISCUSSION: Amphotericin B deoxycholate has been reported to produce significant cardiac toxicity, with ventricular arrhythmias and bradycardia reported in overdoses in children and in adults with preexisting cardiac disease, even when administered in conventional dosages and infusion rates.

produce

in children and in adults with preexisting cardiac disease

in children and in adults

preexisting cardiac disease

cardiac toxicity, with ventricular arrhythmias and bradycardia

Amphotericin B deoxycholate

conventional dosages and infusion rates

Amphotericin B deoxycholate

conventional dosages

infusion


Input: Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.

developed

male 60 yrs of age

male

60 yrs of age

Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates

oxaliplatinum and 5-fluorouracil

oxaliplatinum

unresectable rectum carcinoma

oxaliplatinum


Input: Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.

related

tardive seizures

piperacillin and cefotiam

piperacillin

cefotiam

piperacillin

cefotiam


Input: A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy.

after

A 55-yr-old man

man

prolonged jaundice and sicca complex

a course of thiabendazole

thiabendazole


Input: Methylphenidate (Ritalin)-associated cataract and glaucoma.

associated

cataract and glaucoma

Methylphenidate (Ritalin)

Methylphenidate


Input: Simvastatin-nelfinavir interaction implicated in rhabdomyolysis and death.

implicated

rhabdomyolysis and death

Simvastatin-nelfinavir interaction

nelfinavir

Simvastatin

nelfinavir

Simvastatin


Input: Uncontrolled headache induced by oxcarbazepine.

induced

Uncontrolled headache

oxcarbazepine

oxcarbazepine


Input: We now present four cases of RSDS in kidney transplant recipients treated with tacrolimus.

treated

four cases

kidney transplant recipients

kidney transplant

four

RSDS

tacrolimus

tacrolimus


Input: Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma.

induced

Transient neurological disturbances

the chemotherapy of high-dose methotrexate

methotrexate

high-dose

osteogenic sarcoma


Input: Long-term safety and efficacy in patients with uncontrolled partial-onset seizures treated with adjunctive lacosamide: results from a Phase III open-label extension trial.

treated

patients with uncontrolled partial-onset seizures

adjunctive lacosamide

lacosamide

uncontrolled partial-onset seizures


Input: A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.

occur

adults and children

adults

children

movement disorders

carbamazepine (CBZ) therapy

carbamazepine

Tourette's syndrome


Input: On the day before this visit, he had received the third of six serial weekly BCG bladder instillations for the treatment of bladder cancer.

received

he

bladder cancer

he

the third of six serial weekly BCG bladder instillations

bladder instillations

bladder cancer

BCG

weekly


Input: Following a closed mitral valvotomy, she received quinidine, 1.2 g/day, without interruption for 17 years.

received

quinidine, 1.2 g/day

quinidine

1.2 g/day

17 years


Input: We describe a patient in whom noncardiogenic pulmonary edema developed during intrabiliary infusion of monooctanoin.

developed

a patient

noncardiogenic pulmonary edema

intrabiliary infusion of monooctanoin

infusion

monooctanoin


Input: Mitomycin-C is used widely in the treatment of malignancies and is associated with serious dose related adverse effects including the occurrence of hemolytic uremic syndrome.

associated

hemolytic uremic syndrome

Mitomycin-C

malignancies

Mitomycin-C


Input: Valproic acid induced coma is presented in an adult patient without a history of metabolic disease.

induced

adult patient without a history of metabolic disease

adult

coma

Valproic acid

Valproic acid


Input: Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.

developed

Three patients with no history of asthma or allergy

Three

bronchospasm

propranolol

hypertension

propranolol


Input: To report two cases of warfarin therapy in which the addition of tolterodine resulted in prolonged international normalized ratios (INRs).

resulted

two cases

two

prolonged international normalized ratios (INRs)

warfarin therapy in which the addition of tolterodine

warfarin

tolterodine

warfarin

tolterodine


Input: In addition, an immediate erythematous macule was observed on the photopatch test site of mequitazine directly after UV exposure which was similar to the immediate erythema noted in chlorpromazine photoallergy.

observed

an immediate erythematous macule

mequitazine directly after UV exposure

mequitazine

UV exposure


Input: Acetazolamide-accelerated anticonvulsant osteomalacia.

accelerated

anticonvulsant osteomalacia

Acetazolamide

Acetazolamide

anticonvulsant


Input: Both patients suddenly became hypotensive after injection of chymopapain into a disk.

became

Both patients

hypotensive

injection of chymopapain into a disk

injection

chymopapain


Input: Large dose of methylphenidate may cause cataract and glaucoma.

cause

cataract and glaucoma

methylphenidate

methylphenidate


Input: Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.

after

a 54-year-old man

man

Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked

quinine sulfate

leg cramps

quinine sulfate


Input: Carbamazepine-induced tics.

induced

tics

Carbamazepine

Carbamazepine


Input: Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.

had

Three patients are reported without a history of angina pectoris

Three

myocardial ischemia

during and immediately after BCNU infusion

BCNU

immediately after

infusion


Input: A rare debilitating neurological adverse effect of ranolazine due to drug interaction with clarithromycin.

adverse effect

debilitating neurological

ranolazine

clarithromycin

clarithromycin

ranolazine

clarithromycin

ranolazine


Input: Septic knee arthritis after intra-articular hyaluronate injection.

after

Septic knee arthritis

intra-articular hyaluronate injection

injection

hyaluronate


Input: The concomitant use, however, of colchicine and statin has been associated with the rapid onset of muscle weakness.

associated

the rapid onset of muscle weakness

colchicine and statin

colchicine

statin

colchicine

statin


Input: Successful treatment of hyperthyroidism with amiodarone in a patient with propylthiouracil-induced acute hepatic failure.

treatment

a patient with propylthiouracil-induced acute hepatic failure

propylthiouracil-induced acute hepatic failure

amiodarone

hyperthyroidism

amiodarone


Input: Olanzapine-induced parkinsonism associated with smoking cessation.

induced

parkinsonism

associated with smoking cessation

Olanzapine

Olanzapine

cessation


Input: CASE: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.

experienced

an 11-year old male with Budd-Chiari syndrome

11-year old

male

Budd-Chiari syndrome

profound worsening of chronic aphthous ulcers

immunosuppressive therapy was changed from tacrolimus to sirolimus

tacrolimus

sirolimus


Input: We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.

taking

two patients

two

acute hepatitis

riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks

riluzole

7 and 4 weeks

100 mg

daily


Input: An interaction between levodopa and enteral nutrition resulting in neuroleptic malignant-like syndrome and prolonged ICU stay.

resulting

neuroleptic malignant-like syndrome and prolonged ICU stay

levodopa and enteral nutrition

levodopa


Input: Until further data are available, clinicians should be vigilant for a possible drug interaction when tolterodine therapy is initiated in a patient maintained on warfarin therapy.

initiated

a patient

possible drug interaction

tolterodine therapy

tolterodine

warfarin

tolterodine

warfarin


Input: The itch spread to the arms, abdomen and legs and the patient treated himself with clemastine and the itch disappeared.

disappeared.

The itch spread to the arms, abdomen and legs and the patient

himself

himself

itch disappeared

clemastine

clemastine

itch


Input: In this case report we present a rare drug interaction between erythromycin and ergotamine at normal doses causing lower extremity ischemia in a 36-year-old woman.

causing

a 36-year-old woman

woman

lower extremity ischemia

a rare drug interaction between erythromycin and ergotamine at normal doses

erythromycin

ergotamine

normal doses

erythromycin

ergotamine


Input: Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.

occur

Neutropenia and agranulocytosis

phenothiazines and clozapine.

phenothiazines

clozapine


Input: She had been taking rifampin prior to admission for acid-fast bacilli.

taking

She

She

rifampin

acid-fast bacilli


Input: The responsibility of CCNU in the pathogenesis of pulmonary fibrosis seems very likely.

responsibility

pathogenesis of pulmonary fibrosis

CCNU

CCNU


Input: Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.

taking

a patient

Malignant mixed mullerian tumor of the uterus

raloxifene

raloxifene


Input: Fatal overdoses associated with quetiapine.

associated

Fatal overdoses

quetiapine

quetiapine


Input: Gemcitabine-induced rectus abdominus radiation recall.

induced

rectus abdominus radiation recall

Gemcitabine

Gemcitabine


Input: We report on a serious side effect in a severely depressed 55-year-old woman, who presented an erythematous pigmented skin rash on the whole body under combination treatment with antidepressants, atypical antipsychotic drugs, the mood stabilizer lithium and the lipid-lowering drug pravastatin.

presented

depressed 55-year-old woman

woman

erythematous pigmented skin rash on the whole body

combination treatment with antidepressants, atypical antipsychotic drugs, the mood stabilizer lithium and the lipid-lowering drug pravastatin

depressed

antidepressants

atypical antipsychotic

lithium

pravastatin

antidepressants

atypical antipsychotic

lithium

pravastatin


Input: We present a 20-year-old woman with Basedow-Graves' disease who developed PTU-induced fulminant hepatitis, which progressed to acute hepatic failure with grade III hepatic encephalopathy.

induced

a 20-year-old woman with Basedow-Graves' disease

woman

fulminant hepatitis, which progressed to acute hepatic failure with grade III hepatic encephalopathy

PTU

Basedow-Graves' disease

PTU


Input: The European Organization for Research and Treatment of Cancer 58881 study was designed to test in a prospective multicentric randomized trial the value of high-dose (HD) intravenous (IV) cytarabine (Ara-C) added to HD IV methotrexate (MTX) to reduce the incidence of CNS and systemic relapses in children with increased-risk acute lymphoblastic leukemia (ALL) or stage III and IV lymphoblastic lymphoma treated with a Berlin-Frankfurt-Munster (BFM)-based regimen.

to

children with increased-risk acute lymphoblastic leukemia (ALL) or stage III and IV lymphoblastic lymphoma

children

reduce the incidence of CNS and systemic relapses

high-dose (HD) intravenous (IV) cytarabine (Ara-C) added to HD IV methotrexate (MTX)

high-dose

intravenous

cytarabine

methotrexate

acute lymphoblastic leukemia

stage III and IV lymphoblastic lymphoma

cytarabine

methotrexate


Input: The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.

occur:

neuroleptic toxicity

lithium

lithium


Input: Trans-catheter hepatic arterial injection of lipiodol soluble anti-cancer agent SMANCS and ADR suspension in lipiodol combined with arterial embolization and local hyperthermia for treatment of hepatocellular carcinoma.

treatment

Trans-catheter hepatic arterial injection of lipiodol soluble anti-cancer agent SMANCS and ADR suspension in lipiodol combined with arterial embolization and local hyperthermia

hepatocellular carcinoma

arterial injection

SMANCS

ADR

ADR

SMANCS


Input: Gynecomastia associated with theophylline.

associated

Gynecomastia

theophylline

theophylline


Input: Arthritis and bursitis in multiple sclerosis patients treated with interferon-beta.

treated

multiple sclerosis patients

interferon-beta

interferon-beta

multiple sclerosis


Input: To our knowledge, drug-induced fever has not been reported with the use of diltiazem hydrochloride, a commonly prescribed calcium channel blocker.

induced

fever

drug

with the use of diltiazem hydrochloride, a commonly prescribed calcium channel blocker

diltiazem hydrochloride


Input: Case studies in heparin-induced thrombocytopenia.

induced

thrombocytopenia

heparin

heparin


Input: We describe a 41 yr old leprosy patient treated for 10 yrs with clofazimine who underwent laparotomy for severe abdominal pain.

for

a 41 yr old leprosy patient

41 yr old

severe abdominal pain

10 yrs with clofazimine

leprosy

10 yrs

clofazimine


Input: Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines.

side effect

Osteonecrosis

antiemetic treatment with dexamethasone

dexamethasone


Input: We report the development of scrotal ulcer in a patient with acute promyleocytic leukemia (APL) within 10 days of treatment with ATRA at a dose of 40 mg orally twice daily.

development

a patient with acute promyleocytic leukemia (APL)

scrotal ulcer

within 10 days of treatment with ATRA at a dose of 40 mg orally twice daily

within 10 days

ATRA

40 mg

orally

twice daily

acute promyleocytic leukemia (APL)