Input: One case of priapism occurred during heparin therapy for a previous surgical operation to the knee is reported.

occurred

One case

priapism

during heparin therapy

heparin

surgical operation to the knee


Input: While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.

cause

permanent visual changes

amiodarone and digoxin

amiodarone

digoxin

amiodarone

digoxin


Input: AIM: Report of a case of a woman patient who developed celiac disease after pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C.

developed

a woman patient

woman

celiac disease

pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C.

pegylated interferon alpha-2a

ribavirin

chronic hepatitis C.

ribavirin

pegylated interferon alpha-2a


Input: Differential diagnoses included ocular rosacea with cicatrizing conjunctivitis and 5-FU-induced ectropion.

induced

ectropion


Input: In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.

induce

In rare cases

cancer-associated hemolytic uremic syndrome

hemolytic anemia, thrombocytopenia and progressive renal failure

mitomycin C (MMC)

mitomycin C


Input: Hemolytic uremic syndrome following the infusion of oxaliplatin: case report.

following

Hemolytic uremic syndrome

oxaliplatin

oxaliplatin


Input: Tacrolimus (FK506)-induced mutism after liver transplant.

induced

mutism

Tacrolimus (FK506)

Tacrolimus


Input: Though proteinuria and nephrotic syndrome is a rare adverse effect of IFN-beta-1b therapy, physicians treating MS patients with this agent should pay careful attention to new clinical symptoms and laboratory findings.

adverse effect

MS patients

proteinuria and nephrotic syndrome

MS


Input: It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms.

induced

lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms

sulfasalazine

sulfasalazine


Input: By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.

induced

platelet activation

standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG)

Fragmin

Fraxiparin

Clexane


Input: DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse.

lead

This case

hyperlactatemia relapse

zidovudine

zidovudine


Input: Acute leukaemia during tamoxifen therapy.

during

Acute leukaemia

tamoxifen therapy

tamoxifen


Input: Heparin-associated thrombocytopenia: successful therapy with the heparinoid Org 10172 in a patient showing cross-reaction to LMW heparins.

associated

a patient

thrombocytopenia

Heparin

Heparin


Input: A patient presented with a painful, oedematous, cyanosed hand having injected a solution of diamorphine and methylphenidate into his radial artery.

presented

A patient

painful, oedematous, cyanosed hand

injected a solution of diamorphine and methylphenidate into his radial artery

injected

into his radial artery

diamorphine

methylphenidate

diamorphine

methylphenidate


Input: We conclude that vincristine and actinomycin D were the cause of this rare from of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.

cause

hepatotoxicity

vincristine and actinomycin D

vincristine

actinomycin D

vincristine

actinomycin D


Input: Pure red cell aplasia associated with fenoprofen.

associated

Pure red cell aplasia

fenoprofen

fenoprofen


Input: A 56-year-old white woman with a diagnosis of reactive depression developed severe UI after a 30 days' treatment with venlafaxine 75 mg/day.

after

A 56-year-old white woman with a diagnosis of reactive depression

white

woman

severe UI

30 days' treatment with venlafaxine 75 mg/day.

reactive depression

30 days

venlafaxine

75 mg/day


Input: PATIENTS: Three patients developed a reproductive endocrine disorder during treatment with valproate.

developed

Three patients

Three

reproductive endocrine disorder

valproate

valproate


Input: OBJECTIVE: To report a case of marked elevation of serum creatine kinase (CK) associated with olanzapine therapy.

associated

marked elevation of serum creatine kinase

olanzapine

olanzapine


Input: Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.

occurred

2 patients (6.1%)

Severe C. difficile colitis

cisplatin-based combination chemotherapy

cisplatin

ovarian malignancies

chemotherapy


Input: A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.

developed

A 56-year-old woman with scleroderma

woman

rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis

27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.

scleroderma

27 months

D-penicillamine

1,200 g.


Input: High-dose phosphate treatment leads to hypokalemia in hypophosphatemic osteomalacia.

leads

hypokalemia

High-dose phosphate

hypophosphatemic osteomalacia

phosphate

High-dose


Input: We report a patient who developed heparin associated thrombocytopenia during continuous arteriovenous haemofiltration and discuss its implications and alternative anticoagulant treatment.

during

a patient

heparin associated thrombocytopenia

heparin

continuous arteriovenous haemofiltration

heparin


Input: We describe a detailed case of fulminant hepatitis induced by nevirapine (Viramune) and treated by liver transplantation.

induced

fulminant hepatitis

nevirapine

nevirapine


Input: The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.

associated

patients

ARF

mannitol infusion

mannitol

infusion


Input: In this case report, we present clinical and laboratory findings of a case with chronic hepatitis B that developed acute dystonia soon after the first dose of pegylated interferon alpha.

after

a case with chronic hepatitis B

a

acute dystonia

the first dose of pegylated interferon alpha.

chronic hepatitis B

first dose

pegylated interferon alpha


Input: Trichiasis associated with prostaglandin analog use.

associated

Trichiasis

prostaglandin analog

prostaglandin analog


Input: The possible development of a drug-induced vasculitis or lupus-like syndrome should be added to the list of rare toxic effects of vancomycin.

development

drug-induced vasculitis or lupus-like syndrome

vancomycin

vancomycin


Input: Healthcare professionals should be aware of the possible development of serotonin syndrome as a complication of initiation of fentanyl and other phenylpiperidine opioids in patients treated with SSRIs.

development

patients

serotonin syndrome

fentanyl and other phenylpiperidine opioids

treated with SSRIs

fentanyl

phenylpiperidine opioids

SSRIs

phenylpiperidine opioids

fentanyl

SSRIs


Input: Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.

following

Acute myocardial ischemia

accidental intravenous administration of epinephrine in high concentration

intravenous administration

epinephrine

high concentration


Input: Bromide intoxication secondary to pyridostigmine bromide therapy.

secondary

Bromide intoxication

pyridostigmine bromide

pyridostigmine bromide


Input: We have recently encountered a patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke while being treated with pFVIII.

treated

patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke

thrombotic left middle cerebral artery distribution stroke

pFVIII

acquired haemophilia

pFVIII


Input: We present a case of serotonin syndrome, which was precipitated by this medicine in a patient who had been predisposed by long-term treatment with sertraline, a selective serotonin reuptake inhibitor.

precipitated

a patient

serotonin syndrome

long-term treatment with sertraline

sertraline

long-term


Input: Of the 15 patients treated with tizanidine and mexiletine, 4 suffered tizanidine-induced adverse effects such as drowsiness and dry mouth in the retrospective survey.

induced

15 patients

drowsiness and dry mouth

tizanidine and mexiletine

tizanidine

mexiletine

tizanidine

tizanidine

mexiletine


Input: Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.

during

Type I second-degree AV block (Mobitz type I, Wenckebach AV block)

ritodrine

preterm labor

ritodrine


Input: After other potential causes of liver toxicity were excluded, TMP-SMX was determined to be the cause of his acute liver toxicity.

determined

acute liver toxicity

TMP-SMX

TMP

SMX

TMP

SMX


Input: One of the patients had a dexamethasone dependent brain metastatic condition.

had

One of the patients

One

brain metastatic condition

dexamethasone

dexamethasone

brain metastatic condition


Input: Biomicroscopy revealed amiodarone corneal deposits.

revealed

amiodarone corneal deposits

Biomicroscopy

Biomicroscopy


Input: This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.

unpredictable

irreversible vision loss

ethambutol

ethambutol


Input: Recently, some studies have also reported association between patients with juvenile rheumatoid arthritis (JRA) treated with Methotrexate (MTX) and malignant lymphoma developing.

association

patients with juvenile rheumatoid arthritis (JRA

malignant lymphoma

Methotrexate (MTX)

Methotrexate

juvenile rheumatoid arthritis


Input: The two middle aged women presented with respiratory symptoms after prolonged treatment with nitrofurantoin.

presented

The two middle aged women

two

middle aged

women

respiratory symptoms

prolonged treatment with nitrofurantoin

prolonged treatment

nitrofurantoin


Input: OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.

developed

a patient with rheumatoid arthritis

rheumatoid arthritis

fever, pancytopenia, splenomegaly, and extreme hyperferritinemia

adalimumab

adalimumab


Input: Visual hallucinations associated with zonisamide.

associated with

Visual hallucinations

zonisamide

zonisamide


Input: Milk-alkali syndrome induced by 1,25(OH)2D in a patient with hypoparathyroidism.

induced

a patient with hypoparathyroidism.

Milk-alkali syndrome

hypoparathyroidism


Input: We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis.

appeared

a female acromegalic patient

acromegalic

female

hepatic adenomas

danazol treatment

uterine fibromatosis.

danazol


Input: Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients.

induced

psychiatric patients

psychiatric

Carbamazepine toxicity

clarithromycin

clarithromycin

Carbamazepine

clarithromycin

Carbamazepine


Input: Thrombolytic therapy with tissue plasminogen activator (tPA) for acute myocardial infarction may result in major bleeding complications such as gastrointestinal or intracranial bleeding.

result

gastrointestinal or intracranial bleeding

tissue plasminogen activator

acute myocardial infarction

tissue plasminogen activator


Input: CONCLUSION: The hemolytic-uremic syndrome may be a rare complication of oxaliplatin-based chemotherapy.

complication

hemolytic-uremic syndrome

oxaliplatin-based chemotherapy

oxaliplatin

chemotherapy


Input: However, recurrent staphylococcus aureus sepsis developed during CyA therapy.

developed

staphylococcus aureus sepsis

CyA therapy

CyA


Input: Nabumetone-associated interstitial nephritis.

associated

interstitial nephritis

Nabumetone

Nabumetone


Input: A short review on imatinib-related hepatotoxicity is also presented.

related

hepatotoxicity

imatinib

imatinib


Input: Fatal interstitial pneumonitis associated with docetaxel administration in a patient with hormone-refractory prostate cancer.

associated

a patient with hormone-refractory prostate cancer

Fatal interstitial pneumonitis

docetaxel

docetaxel

hormone-refractory prostate cancer


Input: BACKGROUND: Etanercept is a tumor necrosis factor (TNF) inhibitor that has been licensed in the United States for the treatment of adult and juvenile rheumatoid arthritis as well as psoriatic arthritis.

licensed

adult and juvenile rheumatoid arthritis as well as psoriatic arthritis

adult

juvenile

Etanercept

a tumor necrosis factor (TNF) inhibitor

Etanercept

adult and juvenile rheumatoid arthritis

psoriatic arthritis


Input: Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.

following

Reye-like syndrome

calcium hopantenate

calcium hopantenate


Input: Sudden death in an infant from methemoglobinemia after administration of "sweet spirits of nitre".

after

an infant

infant

Sudden death

methemoglobinemia

sweet spirits of nitre

sweet spirits of nitre


Input: FINDINGS: Six children with growth retardation noted after treatment with high-dose fluticasone propionate were found to have adrenal suppression.

have

Six children with growth retardation

Six

children

adrenal suppression

high-dose fluticasone propionate

high-dose

fluticasone propionate

growth retardation


Input: Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.

associated

nephropathy

Methotrexate

Methotrexate


Input: Four cases of oesophageal damage associated with ingestion of the urinary anti-spasmodic agent emepronium bromide are described.

associated

Four cases

Four

oesophageal damage

ingestion of the urinary anti-spasmodic agent emepronium bromide

ingestion

emepronium bromide


Input: A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.

developed

A 66-year-old Japanese woman with severe scleroderma

Japanese

woman

anemia and thrombocytopenia

D-penicillamine (D-Pen) treatment

severe scleroderma

D-penicillamine


Input: Corticosteroid injections are commonly used as effective treatments for a variety of pain disorders.

treatments

Corticosteroid injections

Corticosteroid

injections

pain disorders


Input: We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol.

occurred

return of spontaneous circulation

epinephrine

administration of the alpha-agonist metaraminol

anaphylaxis under anaesthesia

metaraminol

epinephrine

epinephrine

metaraminol


Input: A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure.

developed

A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria

male

attacks of asthma

captopril was added to the nadolol and dyazide

high blood pressure

captopril

nadolol

dyazide

captopril

nadolol

dyazide


Input: After ticlopidine was discontinued, the patient was rechallenged with the same dose of phenytoin without symptoms of toxicity.

toxicity.

toxicity

After ticlopidine was discontinued

rechallenged with the same dose of phenytoin

ticlopidine

phenytoin


Input: Rhabdomyolysis due to an uncommon interaction of ciprofloxacin with simvastatin.

due

Rhabdomyolysis

interaction of ciprofloxacin with simvastatin

ciprofloxacin

simvastatin

ciprofloxacin

simvastatin


Input: After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive.

found

she

she

unresponsive

ifosfamide/mesna

ifosfamide

mesna

ifosfamide

mesna


Input: Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction.

secondary to

Symptomatic hypoglycemia

glipizide-trimethoprim/sulfamethoxazole drug interaction

glipizide

trimethoprim

sulfamethoxazole

glipizide

trimethoprim

sulfamethoxazole


Input: A 51-year-old man developed type 1 diabetes mellitus following 24 weeks of treatment with recombinant alpha-2b peginterferon plus ribavirin for chronic hepatitis C.

developed

A 51-year-old man

man

type 1 diabetes mellitus

24 weeks of treatment with recombinant alpha-2b peginterferon plus ribavirin

24 weeks

recombinant alpha-2b peginterferon

ribavirin

chronic hepatitis C.

recombinant alpha-2b peginterferon

ribavirin


Input: A noninvasive method in the differential diagnosis of vecuronium-induced and magnesium-induced protracted neuromuscular block in a severely preeclamptic patient.

induced

severely preeclamptic patient

severely preeclamptic

protracted neuromuscular block

vecuronium

vecuronium


Input: Paroxysmal supraventricular tachycardia during treatment with cisplatin and etoposide combination.

during

Paroxysmal supraventricular tachycardia

cisplatin and etoposide combination

cisplatin

etoposide

etoposide

cisplatin


Input: Conversely, diffuse interstitial pulmonary fibrosis should be considered in the differential diagnosis of patients receiving methotrexate who develop bilateral pulmonary infiltrates seen on chest roentgenograms.

develop

patients

diffuse interstitial pulmonary fibrosis

bilateral pulmonary infiltrates

methotrexate

methotrexate


Input: An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.

developed

An 83-year-old man

man

symptomatic hypoglycemia

receiving glipizide 10 mg

three days of adding trimethoprim/sulfamethoxazole (TMP/SMX)

three days

trimethoprim

sulfamethoxazole

glipizide

10 mg

glipizide

trimethoprim

sulfamethoxazole


Input: In this case senna was likely the cause of a subacute cholestatic hepatitis exemplifying again the potential role of herbal related liver injury.

cause

a subacute cholestatic hepatitis

herbal related liver injury

senna

senna


Input: Early peritoneal dialysis has not previously been reported for lisinopril induced multiorgan failure.

induced

multiorgan failure

lisinopril

lisinopril


Input: Various case reports concerning dapsone-induced agranulocytosis are reviewed.

induced

agranulocytosis

dapsone

dapsone


Input: We report the first case of a 54-year-old Turkish woman who presented with ceftriaxone-induced FDE.

induced

a 54-year-old Turkish woman

Turkish

woman

FDE

ceftriaxone

ceftriaxone


Input: In all cases, seizures were controlled by withdrawal of phenytoin and reduction of drug levels.

controlled

seizures

withdrawal of phenytoin and reduction of drug levels

phenytoin


Input: This case describes fulminant hepatic failure in a patient taking disulfiram with no previous liver disease and report of being compliant with alcohol abstinence.

in

a patient

fulminant hepatic failure

disulfiram

disulfiram


Input: Fungal infection is a significant comorbidity in patients with diabetes mellitus, and ketoconazole, an antifungal agent, causes a number of drug interactions with coadministered drugs.

causes

patients with diabetes mellitus

diabetes mellitus

a number of drug interactions with coadministered drugs

ketoconazole

ketoconazole

Fungal infection


Input: Dorzolamide-induced choroidal detachment in a surgically untreated eye.

induced

a surgically untreated eye

choroidal detachment

Dorzolamide

Dorzolamide


Input: Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.

contribute

impaired tissue perfusion

vasopressin

vasopressin


Input: Rapid resolution of topiramate-induced angle-closure glaucoma with methylprednisolone and mannitol.

resolution

methylprednisolone and mannitol

topiramate-induced angle-closure glaucoma

methylprednisolone

mannitol

methylprednisolone

mannitol


Input: A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments.

took

A 66-year-old mand suffering from severe coronary heart disease

mand

coronary heart disease

complete atrioventricular block

digoxin

digoxin


Input: A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment.

managed

MM

generalized MG

MM


Input: Epoprostenol may be associated rarely with severe erythroderma.

associated

severe erythroderma.

Epoprostenol

Epoprostenol


Input: We report the case of a patient with increased cerebral cortical excitability following intoxication with flupirtine, a centrally acting analgesic and antispastic drug.

following

a patient

increased cerebral cortical excitability

flupirtine

flupirtine


Input: This case represents the third example of erythroid aplasia associated with an anti-inflammatory agent and the first instance due to fenoprofen.

associated

erythroid aplasia

fenoprofen

fenoprofen


Input: Lichenoid drug eruption to salsalate.

eruption

Lichenoid drug eruption

salsalate

salsalate


Input: Two pediatric oncology patients with Ewing's sarcoma and one with mixed germ cell tumor were treated with drug regimens that included bleomycin or cyclophosphamide.

treated with

Two pediatric oncology patients with Ewing's sarcoma and one with mixed germ cell tumor

Two

one

pediatric

drug regimens that included bleomycin or cyclophosphamide

bleomycin

cyclophosphamide

Ewing's sarcoma

mixed germ cell tumor


Input: Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: "the retinoic acid syndrome".

complication

fatal complication

retinoic acid

retinoic acid


Input: Three of 38 children given high-dose cytosine arabinoside therapy developed a previously undescribed complication.

developed

38 children

children

complication

high-dose cytosine arabinoside

high-dose

cytosine arabinoside


Input: A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy.

in

a patient with chronic plaque psoriasis

aseptic pleuropericarditis

methotrexate therapy

methotrexate

chronic plaque psoriasis


Input: Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.

induced

dyserythropoiesis

Linezolid

Linezolid


Input: CONCLUSION: The present findings suggest that fluvoxamine can cause increased libido in some patients.

cause

some patients

increased libido

fluvoxamine

fluvoxamine


Input: A unique case of a transient, nonpigmenting fixed drug eruption caused by the radiopaque contrast medium iothalamate is reported.

caused

a transient, nonpigmenting fixed drug eruption

iothalamate

iothalamate


Input: Mucosal pigmentation after oral lichen planus treatment with topical tacrolimus.

treatment

Mucosal pigmentation

topical tacrolimus

oral lichen planus

tacrolimus

topical


Input: We now report the first known cancer patient who developed life-threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency.

developed

cancer patient

life-threatening complications

have profound DPD deficiency

topical 5-FU

cancer

topical


Input: When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.

associated with

acute manic state is characterized by marked psychotic symptoms and intense anxiety

lithium

lithium


Input: Clinicians who manage cachectic patients, particularly those with protracted diarrhoea and/or receiving anti-malarial drugs including mefloquine, should be aware of the risk of severe hypoglycaemia.

risk

cachectic patients

with protracted diarrhoea

severe hypoglycaemia

anti-malarial drugs including mefloquine

mefloquine

cachectic

protracted diarrhoea


Input: Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them.

during

Arrhythmias and cardiac arrest

amphotericin B administration

amphotericin B


Input: Based upon the literature review, the hypotension in this patient was possibly due to the interaction between tizanidine and lisinopril.

due

this patient

the hypotension

the interaction between tizanidine and lisinopril

tizanidine

lisinopril

tizanidine

lisinopril


Input: Baclofen withdrawal: a cause of prolonged fever in the intensive care unit.

cause

prolonged fever

Baclofen withdrawal

Baclofen


Input: Interstitial pneumonitis and alveolar hemorrhage complicating use of rituximab: case report and review of the literature.

complicating

Interstitial pneumonitis and alveolar hemorrhage

rituximab

rituximab


Input: We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).

after

a sixty years old woman

sixty years old

woman

several previous episodes of rhinitis, conjunctivitis and perspiration immediately

salmon calcitonin with nasal spray or intramuscular administration (Calsynar)

nasal spray

intramuscular

salmon calcitonin


Input: In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.

following

a 46-year-old female patient

female

subcutaneous changes

presented as localized panniculitis in the area around the injection sites

repeated glatiramer acetate injection

glatiramer acetate

injection


Input: Eighty-two patients with various malignancies who received imipenem/cilastatin 143 times for neutropenic fever between March 1994 and October 1999 in Department of Pediatric Oncology, Gazi University, were identified.

received

Eighty-two patients with various malignancies

Eighty-two

various malignancies

imipenem/cilastatin 143 times for neutropenic fever

imipenem

cilastatin

neutropenic fever

imipenem

cilastatin


Input: The present report first highlights the potentially life-threatening side effects associated with over-the-counter NSAIDs during DDAVP replacement therapy for central DI.

associated with

potentially life-threatening side effects

NSAIDs

NSAIDs

DDAVP

NSAIDs

DDAVP


Input: Case report: lack of control of diabetes and weight gain in a patient on initiation and rechallenge of therapy with olanzapine.

initiation and rechallenge

a patient

diabetes

weight gain

olanzapine

olanzapine


Input: Intravenous azithromycin-induced ototoxicity.

induced

ototoxicity

azithromycin

azithromycin


Input: Orally delivered PXD showed no evidence of clinical activity, when combined with weekly AUC2-carboplatin in PROC.

clinical activity,

Orally delivered PXD

weekly AUC2-carboplatin

PROC

Orally

PXD

weekly

PXD


Input: We report such a series of patients who had transient asymptomatic bradycardia after being treated with continuous infusion 5-FU.

after

a series of patients

a series

transient asymptomatic bradycardia

continuous infusion 5-FU

continuous

infusion


Input: Consolidation therapy with bortezomib/lenalidomide/ dexamethasone versus bortezomib/dexamethasone after a dexamethasone-based induction regimen in patients with multiple myeloma: a randomized phase III trial.

in

patients with multiple myeloma

Consolidation therapy with bortezomib/lenalidomide/ dexamethasone versus bortezomib/dexamethasone after a dexamethasone-based induction regimen

multiple myeloma

bortezomib

lenalidomide/

dexamethasone

bortezomib

dexamethasone

bortezomib

lenalidomide/

dexamethasone

bortezomib

dexamethasone


Input: Based on prior data suggesting that scheduling alterations of platinum would increase activity, the aim of the present study was to assess the potential therapeutic benefit of phenoxodiol (PXD), a novel biomodulator shown to have chemoresistance reversing potential, when combined with weekly AUC2-carboplatin in PROC patients.

assess

PROC patients

potential therapeutic benefit

phenoxodiol (PXD), a novel biomodulator shown to have chemoresistance reversing potential, when combined with weekly AUC2-carboplatin

phenoxodiol

carboplatin

PROC

weekly

carboplatin

phenoxodiol


Input: We also describe a new, noninvasive method to assess magnesium-induced neuromuscular block when curariform muscle relaxant was given simultaneously.

induced

neuromuscular block

curariform muscle relaxant was given simultaneously

magnesium

curariform muscle relaxant

magnesium

curariform muscle relaxant


Input: Our series of 3 patients supports a causal connection between bleomycin and scleroderma.

supports

3 patients

scleroderma

bleomycin

bleomycin


Input: In this paper, we report a patient with primary anti-phospholipid syndrome treated by corticosteroid, who developed disseminated nocardiosis.

developed

a patient

disseminated nocardiosis

corticosteroid

corticosteroid

anti-phospholipid syndrome


Input: Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir.

on

bone marrow transplant patients

bone marrow transplant

Eye movement disorders

cyclosporin and ganciclovir

cyclosporin

ganciclovir

cyclosporin

ganciclovir


Input: Prolonged severe cholestasis induced by oxacillin derivatives.

induced

Prolonged severe cholestasis

oxacillin derivatives

oxacillin


Input: Cisplatin was the common drug in the cases presented and therefore could be related to the INR elevations.

related

the cases

INR elevations

Cisplatin

Cisplatin


Input: 5-Fluorouracil cardiotoxicity complicating treatment of stage IIB cervical cancer--case report.

complicating

cardiotoxicity

cervical cancer


Input: RESULTS: A clinical diagnosis of fixed drug eruption owing to use of the PDE5 inhibitor tadalafil (Cialis) was made.

owing

fixed drug eruption

PDE5 inhibitor tadalafil (Cialis)

tadalafil


Input: Pancytopenia associated with 5-aminosalicylic acid use in a patient with Crohn's disease.

associated

a patient with Crohn's disease

Pancytopenia

5-aminosalicylic acid

Crohn's disease

5-aminosalicylic acid


Input: Fludarabine induced lung toxicity must be considered in all patients who develop unexplained lung disease while receiving fludarabine.

receiving

all patients who develop unexplained lung disease

lung disease

Fludarabine induced lung toxicity

fludarabine

fludarabine


Input: Although other nitrites induce methemoglobinemia, exposure to methyl nitrite during phenylpropanolamine production appears to be a new cause of occupational methemoglobinemia.

cause

occupational methemoglobinemia

methyl nitrite

methyl nitrite


Input: We report four cases of sensorimotor axonal neuropathy in children aged 10-15 years, treated with thalidomide for myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration.

treated

four cases

children aged 10-15 years

myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration

four

10-15 years

sensorimotor axonal neuropathy

thalidomide

thalidomide

myxopapillary ependymoma

Crohn's disease

recurrent giant aphthous ulceration


Input: The patient died of respiratory failure after 8 days of steroid infusion and erlotinib discontinuation.

after

The patient

The

died of respiratory failure

8 days of steroid infusion and erlotinib discontinuation.

after 8 days

steroid

erlotinib

infusion


Input: Hypo-oestrogenic and anabolic/androgenic side-effects of danazol are well known by the gynaecologist and some of them are present in > 50% of patients being treated for endometriosis.

side-effects

Hypo-oestrogenic and anabolic/androgenic

danazol

danazol

endometriosis


Input: We believe that this is the first description of acute hepatitis caused by an idiosyncratic adverse reaction to gliclazide or to one of its metabolites.

idiosyncratic adverse reaction

acute hepatitis

gliclazide

gliclazide


Input: In view of our experience in the present case, it should be stressed that close monitoring of coagulation capacity is necessary in critically ill patients in order to avoid fatal haemorrhage after initiating warfarin therapy regardless of the dosage.

after

haemorrhage

initiating warfarin therapy regardless of the dosage

warfarin


Input: We report a patient who developed acute pancreatitis during amiodarone therapy.

during

a patient

acute pancreatitis

amiodarone

amiodarone


Input: We report a 76-year-old man who developed an acute blistering eruption following high-dose penicillin treatment for pneumococcal septicaemia.

developed

76-year-old man

man

acute blistering eruption

high-dose penicillin treatment

penicillin

high-dose

pneumococcal septicaemia


Input: OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).

induced

a teenager with familial Mediterranean fever (FMF)

teenager

myopathy

colchicine

familial Mediterranean fever

colchicine


Input: We believe that mucositis was a contributing factor to this case of fatal hyperkalemia after administration of succinylcholine, with a mechanism similar to that reported with thermal injury.

after

mucositis

mucositis

fatal hyperkalemia

succinylcholine

succinylcholine


Input: Our experience supports hemodialysis for ESRF patients with atenolol toxicity.

for

ESRF patients with atenolol toxicity

ESRF

hemodialysis

hemodialysis

atenolol toxicity


Input: Epirubicin-cyclophosphamide adjuvant chemotherapy plus tamoxifen administered concurrently versus sequentially: randomized phase III trial in postmenopausal node-positive breast cancer patients.

administered

postmenopausal node-positive breast cancer patients

Epirubicin-cyclophosphamide adjuvant chemotherapy plus tamoxifen administered concurrently

tamoxifen

Epirubicin-cyclophosphamide

node-positive breast cancer

tamoxifen

Epirubicin-cyclophosphamide


Input: Rupture of a cerebral aneurysm associated with nifedipine treatment.

associated

Rupture of a cerebral aneurysm

nifedipine

nifedipine


Input: An immediate hemolytic reaction induced by repeated administration of oxaliplatin.

induced

immediate hemolytic reaction

repeated administration of oxaliplatin

repeated

oxaliplatin


Input: Patient B developed perioral and upper extremity paresthesias during the fourth cycle of CAP alone (2500 mg/m2).

developed

Patient B

perioral and upper extremity paresthesias

the fourth cycle of CAP alone (2500 mg/m2)

CAP

the fourth cycle

2500 mg/m2


Input: We describe four patients who had seizures while receiving ofloxacin; no other causes were evident.

receiving

four patients

four

seizures

ofloxacin

ofloxacin


Input: The case history and toxicological findings of an infant fatality involving pseudoephedrine, brompheniramine, and dextromethorphan are presented.

involving

an infant

infant

infant fatality

pseudoephedrine, brompheniramine, and dextromethorphan

pseudoephedrine

brompheniramine

dextromethorphan


Input: A drug interaction between zafirlukast and theophylline.

between

drug interaction

zafirlukast and theophylline

zafirlukast

theophylline

zafirlukast

theophylline


Input: Dipyrone, also known as metamizole, is an analgesic and antipyretic drug that was banned by the United States Food and Drug Administration because of its association with agranulocytosis.

association

agranulocytosis

Dipyrone, also known as metamizole

Dipyrone


Input: A fatal case of pancytopenia due to levomepromazine.

due

A fatal case

pancytopenia

levomepromazine

levomepromazine


Input: Reversible heart failure in a patient receiving etanercept for ankylosing spondylitis.

in

a patient

Reversible heart failure

etanercept

etanercept

ankylosing spondylitis


Input: The most likely cause of liver failure in this patient was, therefore, clarithromycin, which undergoes hepatic metabolism and has been reported to cause fulminant hepatic failure.

cause

liver failure

clarithromycin

clarithromycin


Input: Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.

with

Localized panniculitis and subsequent lipoatrophy

subcutaneous glatiramer acetate (Copaxone) injection

glatiramer acetate (Copaxone)

injection

multiple sclerosis


Input: glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.

resulting

resolution of bradycardia

an exaggerated increase of arterial blood pressure

glycopyrrolate (5.0 microg/kg)

glycopyrrolate

5.0 microg/kg


Input: This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis.

hypersensitivity,

hypersensitivity

sulfadiazine

sulfadiazine


Input: CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.

treating

patients with clozapine-induced granulocytopenia

without the risk of recurrence of hematologic side effects

olanzapine

olanzapine


Input: CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.

resolution

Patients with insulin allergy

concomitant protamine allergy

insulin allergy

protamine allergy

standard desensitization


Input: To our knowledge, the syndrome of fever, pulmonary infiltrates, and pleural effusion following use of acyclovir has not been previously reported.

following

fever, pulmonary infiltrates, and pleural effusion

acyclovir

acyclovir


Input: We are concerned that the macular lesion was a retinal toxic effect of gentamicin because of the recent description of similar lesions occurring after the inadvertent intraocular injection of massive doses of this drug.

of

macular lesion

gentamicin

gentamicin


Input: Acute myocardial infarction during high-dose methylprednisolone therapy for Graves' ophthalmopathy.

during

Acute myocardial infarction

high-dose methylprednisolone therapy

methylprednisolone

Graves' ophthalmopathy

high-dose


Input: With itraconazole, hepatotoxic reactions have only very rarely been reported, and histologic data are lacking.

reported,

hepatotoxic

itraconazole

itraconazole


Input: We describe in detail the first U.S. case report, of a 4(1/2)-year-old boy who experienced angioedema during treatment with oxcarbazepine.

treatment

a 4(1/2)-year-old boy

boy

angioedema

oxcarbazepine

oxcarbazepine


Input: Caution should be used when coadministering enfuvirtide and niacin to HIV-infected patients.

used

HIV-infected patients

Caution

coadministering enfuvirtide and niacin

enfuvirtide

niacin

HIV

enfuvirtide

niacin


Input: Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature.

reports

Several case

Several

aplastic anemia

acetazolamide

acetazolamide


Input: SSRIs and fentanyl are commonly co-administered, especially in the setting of chronic or malignant pain, as underlying depression may contribute to the pathogenesis of pain.

in

SSRIs and fentanyl are commonly co-administered

chronic or malignant pain

underlying depression

SSRIs

fentanyl

SSRIs

fentanyl


Input: In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.

triggered

four patients

four

asterixis

carbamazepine

carbamazepine


Input: Squamous-cell carcinoma arising in a basal-cell epithelioma treated with 5-fluorouracil.

treated

Squamous-cell carcinoma arising


Input: The case of a bipolar patient who developed thyrotoxicosis with severe exophthalmos while on lithium therapy is described.

on

The case of a bipolar patient

thyrotoxicosis with severe exophthalmos

lithium

lithium

bipolar


Input: The patient received only the ophthalmic sulfonamide, and it was used for one day, but he developed Stevens-Johnson syndrome.

developed

The patient

he

he

Stevens-Johnson syndrome

ophthalmic sulfonamide, and it was used for one day

ophthalmic

sulfonamide

one day


Input: Papillary necrosis associated with the HIV protease inhibitor indinavir.

associated

Papillary necrosis

indinavir

indinavir

HIV


Input: A case is reported of a 40 year old woman treated with intraventricular IL-2 for leptomeningeal disease who developed progressive cognitive dysfunction.

developed

a 40 year old woman

40 year old

woman

progressive cognitive dysfunction

intraventricular IL-2

leptomeningeal disease

intraventricular


Input: We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.

development

surgically untreated eye with primary open-angle glaucoma

extensive choroidal detachment

dorzolamide therapy

dorzolamide

surgically untreated eye with primary open-angle glaucoma


Input: Serotonin toxicity as a consequence of linezolid use in revision hip arthroplasty.

consequence

Serotonin toxicity

linezolid use in revision hip arthroplasty

Serotonin

Serotonin

linezolid


Input: Gallstones and bile sludge are common side effects of octreotide therapy but rarely become symptomatic or require treatment.

side effects of

Gallstones and bile sludge

octreotide therapy

octreotide


Input: The authors' results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson's disease.

cause

some patients with Parkinson's disease

daytime somnolence

L-dopa

L-dopa

Parkinson's disease


Input: Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.

had

Seventy-four per cent of patients with epileptogenic disorders

11.6% of these

Seventy-four per cent

blood levels in the toxic range

phenytoin

phenytoin

epileptogenic


Input: Based on the history and clinical features, a diagnosis of insulin-induced lipohypertrophy was made.

induced

lipohypertrophy

insulin

insulin


Input: An unusual presentation of spontaneous sub-conjunctival haematoma in a patient receiving warfarin.

in

a patient

spontaneous sub-conjunctival haematoma

warfarin

warfarin


Input: He developed congestive heart failure 5 days after administration of cyclophosphamide.

developed

congestive heart failure

5 days after administration of cyclophosphamide

5 days

cyclophosphamide


Input: Fulminant liver failure associated with clarithromycin.

associated

Fulminant liver failure

clarithromycin

clarithromycin


Input: Nifedipine may induce, or aggravate, pre-existing, gastro-oesophageal reflux.

induce, or aggravate,

gastro-oesophageal reflux

Nifedipine

Nifedipine


Input: Rifampin-associated thrombocytopenia secondary to poor compliance.

associated

thrombocytopenia secondary to poor compliance

Rifampin

Rifampin


Input: CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.

relationship

onset of nonconvulsive status epilepticus

initiation of ifosfamide infusion

ifosfamide

infusion


Input: Gemcitabine-induced pericardial effusion and tamponade after unblocked cardiac irradiation.

induced

pericardial effusion and tamponade

Gemcitabine

Gemcitabine

unblocked cardiac irradiation


Input: Although useful in the management of chronic alcoholism, disulfiram is being increasingly associated with a wide spectrum of side effects and untoward medical sequelae, which now include catatonia.

associated

a wide spectrum of side effects and untoward medical sequelae, which now include catatonia

disulfiram

disulfiram

chronic alcoholism


Input: DISCUSSION: The Naranjo probability scale indicated a probable relationship between sertraline treatment and the onset of rhabdomyolysis.

relationship

rhabdomyolysis

sertraline

sertraline


Input: Severe Raynaud's phenomenon with yohimbine therapy for erectile dysfunction.

with

Raynaud's phenomenon

yohimbine

yohimbine

erectile dysfunction


Input: Possible theophylline toxicity during anesthesia.

during

theophylline toxicity

anesthesia

anesthesia


Input: Calcification and ossification of the spinal arachnoid after intrathecal administration of Depo-Medrol.

after

Calcification and ossification of the spinal arachnoid

intrathecal administration of Depo-Medrol

intrathecal

Depo-Medrol


Input: Circulating anticoagulant in the procainamide-induced lupus syndrome.

induced

lupus syndrome

procainamide

procainamide


Input: This report describes a case of bilateral ptosis induced by chloroquine.

induced

a case

bilateral ptosis

chloroquine

chloroquine


Input: When the data of the 57 patients are evaluated, a reversible direct cytotoxic effect of ticlopidine on the pluripotent/bipotent hematopoietic progenitor stem cell is proposed.

proposed.

57 patients

cytotoxic effect

ticlopidine

ticlopidine


Input: We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin.

after

a child with yolk sac tumor

child

localized pigmentation

the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin

the first course

cisplatin

etoposide

bleomycin

yolk sac tumor

cisplatin

etoposide

bleomycin


Input: Except hypothyroidism after radioiodine treatment (euthyroid under substitutional therapy), she suffered from no other diseases.

after

she

she

hypothyroidism

radioiodine treatment (euthyroid under substitutional therapy)

radioiodine


Input: Late lethal hepatitis B virus reactivation after rituximab treatment of low-grade cutaneous B-cell lymphoma.

after

Late lethal hepatitis B virus reactivation

rituximab

low-grade cutaneous B-cell lymphoma

rituximab


Input: Despite the low dosage of warfarin, international normalized ratio (INR) was markedly elevated from 1.15 to 11.28 for only 4 days, and bleeding symptoms concurrently developed.

developed.

international normalized ratio (INR) was markedly elevated

bleeding symptoms

low dosage of warfarin

warfarin

low dosage

4 days


Input: The possible role of interferon beta in the pathogenesis of sarcoidosis in this patient is discussed.

role

this patient

sarcoidosis

interferon beta

interferon beta


Input: We hypothesize that a pharmacodynamic or pharmacokinetic drug interaction between venlafaxine and trimipramine involving the CYP2D6 isoenzyme may have played a role in inducing the seizures.

inducing

seizures

venlafaxine and trimipramine

venlafaxine

trimipramine

venlafaxine

trimipramine


Input: A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction.

developed

severe splenic hemorrhage and rupture

3 h after completion of tPA infusion

suspected acute myocardial infarction

3 h

tPA

infusion


Input: Three weeks later, the decerebrate rigidity and high BP remained, and tizanidine was initiated to see whether the decrease in muscle tone could facilitate hypertension control and motor recovery.

initiated

decerebrate rigidity and high BP

hypertension control and motor recovery

tizanidine

tizanidine

decerebrate rigidity and high BP


Input: CONCLUSIONS: The administration of prostaglandin E1 to neonates can cause gastric-outlet obstruction due to antral hyperplasia.

cause

neonates

neonates

gastric-outlet obstruction due to antral hyperplasia

prostaglandin E1

prostaglandin E1


Input: During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully.

occurrence

IDDM as well as other autoimmune diseases

IFN therapy

IFN therapy

During and after


Input: In two of these cases akathisia resolved after withdrawal of olanzapine and substitution by a classical or an atypical neuroleptic agent, respectively.

resolved

two of these cases

two

akathisia

withdrawal of olanzapine and substitution by a classical

neuroleptic agent

olanzapine

neuroleptic agent


Input: Captopril-related (and -induced?) asthma.

related

asthma

Captopril

Captopril


Input: These findings suggest that clozapine-induced seizures can be successfully treated, that gradual dose titration can reduce the likelihood of further episodes of seizures and that concomitant use of a suitable mood stabilizer/anti-epileptic medication can improve the outcome of treatment-resistant schizophrenia.

induced

seizures

clozapine

clozapine


Input: According to the Naranjo probability scale, the papular eruption was probably caused by methotrexate.

caused

papular eruption

methotrexate

methotrexate


Input: The patient's defects may be due to methimazole teratogenicity or could represent a previously undescribed syndrome affecting ectodermal structures.

due

teratogenicity

methimazole

methimazole


Input: CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia.

induced

liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia

Itraconazole

Itraconazole


Input: Rhabdomyolysis resulting from the drug interaction between diltiazem and other HMG-CoA reductase inhibitors has been described in the literature.

resulting

Rhabdomyolysis

diltiazem and other HMG-CoA reductase inhibitors

diltiazem

HMG-CoA reductase inhibitors

diltiazem

HMG-CoA reductase inhibitors


Input: Acute angioedema response to topical 5-fluorouracil therapy.

response

angioedema


Input: Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature.

due

Hypersensitivity reactions

chloramphenicol

chloramphenicol


Input: Diagnosis of sclerosing glomerulonephritis occurred in this patient during anastrozole use, suggesting a newly defined side effect of anastrozole.

during

patient

sclerosing glomerulonephritis

anastrozole

anastrozole


Input: A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed.

treated with

A patient with coccidioidal meningitis

an acute toxic delirium with EEG abnormalities

intrathecally administered amphotericin B

coccidioidal meningitis

amphotericin B

intrathecally


Input: This case raises important questions about non-ketotic, hyperosmolar diabetic coma with antipsychotics, the possible association between hyperglycaemia and hyperthermia, and the direction of causality in this, the recognition of either syndrome when they co-exist and management issues in such patients.

association

non-ketotic, hyperosmolar diabetic coma

hyperglycaemia and hyperthermia

antipsychotics

antipsychotics


Input: CONCLUSIONS: Reversible lupus-like syndrome appears to be a rare but significant side effect of 5-ASA compounds.

side effect

Reversible lupus-like syndrome


Input: A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.

developed

A patient with chronic myeloid leukaemia

busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice

busulphan for 4-5 years

4-5 years

busulphan

chronic myeloid leukaemia


Input: Several cases of lithium-induced Creutzfeldt-Jakob syndrome have been reported to date; all of them were elderly patients and a half had "therapeutic" lithium serum levels.

induced

elderly patients

elderly

Creutzfeldt-Jakob syndrome

lithium

"therapeutic" lithium serum levels

lithium

lithium


Input: There is, however, currently no data on the effect of combined hyperglycaemia and hyperinsulinaemia on the renal and ocular blood flow seen in diabetic patients on insulin therapy.

on

combined hyperglycaemia and hyperinsulinaemia

diabetic patients

renal and ocular blood flow

insulin therapy

hyperglycaemia

hyperinsulinaemia

diabetic

hyperglycaemia

hyperinsulinaemia


Input: Pemphigus vulgaris precipitated by glibenclamide therapy.

precipitated

Pemphigus vulgaris

glibenclamide

glibenclamide


Input: Methimazole-associated cholestatic liver injury: case report and brief literature review.

associated

cholestatic liver injury

Methimazole

Methimazole


Input: The most likely cause of such hyponatremic episode is vinblastine.

is

hyponatremic episode

vinblastine

vinblastine


Input: Anti-tuberculous drugs had been stopped on the 2nd day of therapy due to development of optic neuritis secondary to ethambutol administration at another hospital.

to

optic neuritis secondary

ethambutol

ethambutol


Input: Based on this experience, we suggest that low-dose ketamine added to propofol may be associated with prevention of EA in children with a history of EA with propofol TIVA.

prevention

children with a history of EA with propofol TIVA

EA with propofol TIVA

children

low-dose ketamine added to propofol

EA

ketamine

propofol

low-dose

ketamine

propofol


Input: Tetany in a child with AIDS receiving intravenous tobramycin.

in

a child with AIDS

child

AIDS

Tetany

intravenous tobramycin

tobramycin

intravenous


Input: Sideroblastic anemia due to linezolid in a patient with a left ventricular assist device.

due

patient with a left ventricular assist device

Sideroblastic anemia

linezolid

linezolid

left ventricular assist device


Input: Oral dapsone has been available for over 60 years and has been used to treat severe acne vulgaris; however, the oral formulation is known to cause dose-dependent haematological reactions and is currently indicated only for diseases such as dermatitis herpetiformis and Hansen's disease.

cause

dose-dependent haematological reactions

Oral dapsone

dapsone

Oral

dermatitis herpetiformis

Hansen's disease


Input: Enalapril-induced anemia in two kidney transplant recipients.

induced

two kidney transplant recipients

anemia

Enalapril

Enalapril

kidney transplant


Input: PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant.

resulted

an infant

infant

apparent central nervous system depression and unresponsiveness

topical brimonidine

topical

brimonidine


Input: BACKGROUND: Interferon beta has become standard therapy for reducing relapse frequency in relapsing/remitting Multiple Sclerosis (RRMS).

standard therapy

Interferon beta

Interferon beta

relapsing/remitting Multiple Sclerosis


Input: In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.

implicated

Epstein's anomaly

lithium

lithium


Input: The risk of gastrointestinal bleeding during the treatment with antiagregants and anticoagulants, the risk of bradycardia in beta-blockade, possible interactions with other medications lowering the heart rate are discussed.

during

gastrointestinal bleeding

antiagregants and anticoagulants

antiagregants

anticoagulants

antiagregants

anticoagulants


Input: Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.

enhanced

two cases.

two

Hepatotoxicity

paracetamol

ingestion of alcohol

paracetamol

alcohol

ingestion

alcohol

paracetamol


Input: Cancer patients who are receiving 5-FU treatment and are DPD deficient can develop severe side effects.

develop

Cancer patients

are DPD deficient

DPD deficient

severe side effects

receiving 5-FU

Cancer


Input: A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.

developed

A patient

his rheumatoid arthritis

his

poorly differentiated sarcoma

cyclophosphamide

cyclophosphamide

rheumatoid arthritis


Input: Photo-onycholysis caused by olanzapine and aripiprazole.

caused

Photo-onycholysis

olanzapine and aripiprazole

olanzapine

aripiprazole


Input: We observed 5 reactions in 3 patients that appear to be related to a high dose-infusion time ratio, indicating that dose and rate of infusion may be important factors in precipitating anaphylactoid reactions with cisplatin.

precipitating

3 patients

anaphylactoid reactions

high dose-infusion time ratio

cisplatin

high dose

cisplatin


Input: CONCLUSION: Fixed drug eruption is associated with many drugs but this is the first such report with omeprazole.

associated

Fixed drug eruption

omeprazole

omeprazole


Input: One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol.

association

SMON

acrodermatitis enteropathica

clioquinol

clioquinol


Input: We report a case of amiodarone-induced thyrotoxicosis of protracted duration, unresponsive to conventional thionamide therapy, with therapy limited by severe adverse drug reactions.

induced

a case

thyrotoxicosis

amiodarone

amiodarone


Input: The addition of ciprofloxacin to chronic simvastatin therapy led to the development of rhabdomyolysis.

led

rhabdomyolysis

ciprofloxacin

chronic simvastatin

ciprofloxacin

chronic simvastatin

ciprofloxacin

chronic simvastatin


Input: Nephropathy caused by methicillin therapy for staphylococcal septicemia.

caused

Nephropathy

methicillin therapy for staphylococcal septicemia

staphylococcal septicemia

methicillin


Input: Four patients in whom pulmonary oedema developed during tocolysis with hexoprenaline are described and the aetiological factors and pathogenesis of this potentially lethal complication discussed.

developed

Four patients

Four

pulmonary oedema

tocolysis with hexoprenaline

hexoprenaline


Input: A case of skeletal fluorosis induced by prolonged treatment with niflumic acid, a fast-acting non-steroid antiinflammatory agent, is reported in a 35-year-old woman suffering from rheumatoid arthritis and treated, in addition, with corticosteroids.

induced

a 35-year-old woman suffering from rheumatoid arthritis

woman

skeletal fluorosis

niflumic acid

in addition, with corticosteroids

niflumic acid

corticosteroids

rheumatoid arthritis

corticosteroids

niflumic acid


Input: A 65-year-old man on warfarin therapy with a sudden spontaneous onset of sub-conjunctival haematoma associated with bloody tears was assessed in the clinic following a referral from an optometrist.

with

A 65-year-old man

man

a sudden spontaneous onset of sub-conjunctival haematoma associated with bloody tears

warfarin therapy

warfarin


Input: This case report describes the development of asymptomatic visual field defects (VFDs) in a psychiatric patient with bipolar disorder receiving adjunctive tiagabine treatment.

development

patient

asymptomatic visual field defects

tiagabine

bipolar disorder

tiagabine


Input: Cardiorespiratory toxicity due to miconazole.

due to

Cardiorespiratory toxicity

miconazole

miconazole


Input: Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin.

induced

rhabdomyolysis

clarithromycin

azithromycin

Lovastatin

clarithromycin

azithromycin

Lovastatin

clarithromycin

azithromycin


Input: For prevention of CYP2E1-mediated bioactivation, depending on protoxicant disposition, a second DSF dose might be necessary to completely prevent toxicity.

to

a second DSF dose

protoxicant

DSF

a second DSF dose


Input: We describe a patient with rheumatoid arthritis treated with gold salts, who developed bilateral interstitial pulmonary abnormalities and showed a dramatic response on corticosteroid therapy.

treated with

a patient with rheumatoid arthritis

bilateral interstitial pulmonary abnormalities

gold salts

gold salts

corticosteroid

rheumatoid arthritis


Input: Pneumonitis is emerging as one of the most unpredictable and potentially serious, adverse effects of treatment with MTX.

with

Pneumonitis

MTX

MTX


Input: A chronic reaction associated with long-term treatment with nitrofurantoin has also been reported and causes irreversible pulmonary fibrosis.

causes

irreversible pulmonary fibrosis

long-term treatment with nitrofurantoin

long-term treatment

nitrofurantoin


Input: Nitrofurantoin-induced acute liver damage in pregnancy.

induced

pregnancy

acute liver damage

Nitrofurantoin

Nitrofurantoin


Input: A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr.

developed

A 58-yr-old male patient with essential thrombocythaemia (ET)

male

chronic myeloid leukaemia (CML)

continuous uneventful treatment with hydroxyurea for 18 yr

essential thrombocythaemia (ET)

hydroxyurea

18 yr


Input: A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).

developed

A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck

64 year old

man

skin rash and bone marrow aplasia

a single dose of 40 mg/m2 methotrexate (MTX)

recurrent metastatic squamous cell carcinoma of the head and neck

40 mg/m2

methotrexate

a single dose

4 and 7 days


Input: We present four cases in which the use of heparin was associated with hyperkalemia and discuss the pathophysiology.

associated

four cases

four

hyperkalemia

heparin

heparin


Input: Three cycles of chemotherapy had been administered without complications when, at the beginning of the fourth cycle, the patient developed clinical and laboratory abnormalities consistent with the development of the hemolytic-uremic syndrome.

developed

the patient

hemolytic-uremic syndrome.

chemotherapy

at the beginning of the fourth cycle

chemotherapy

fourth cycle


Input: Keratitis in methamphetamine abusers.

in

Keratitis

methamphetamine abusers

methamphetamine


Input: A rechallenge, performed in both patients, confirmed the diagnosis of mesalamine-induced pancreatitis.

induced

both patients

pancreatitis

mesalamine

mesalamine


Input: Central nervous system toxicity associated with meperidine use in hepatic disease.

associated

Central nervous system toxicity

meperidine

hepatic disease

meperidine


Input: To our knowledge, this case is the first published report of levofloxacin-induced TEN.

induced

TEN

levofloxacin

levofloxacin


Input: On the second day of hospitalization, it was noted that the patient's dyspnea and sinus bradycardia could be related to a recent increase in his timolol dosage.

related

patient

dyspnea and sinus bradycardia

a recent increase in his timolol dosage

timolol


Input: Three months following splenectomy, multiple abscesses occurred in the muscles of both thighs while the patient was receiving the third course of the CHOP regimen.

while

the patient

multiple abscesses occurred in the muscles of both thighs

Three months following splenectomy

third course of the CHOP regimen

Three months

splenectomy

CHOP

third course

CHOP

splenectomy


Input: Methylene blue is used in a variety of surgical settings as well as for treatment of various types of hypotensive shock and methemoglobinaemia.

treatment

Methylene blue

hypotensive shock

methemoglobinaemia

Methylene blue


Input: Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.

cause

central nervous system insult

Methanol toxicity

Methanol


Input: We believe that these skin eruptions belong to a spectrum of neutrophilic dermatoses that can be induced or aggravated by G-CSF therapy.

induced

skin eruptions

G-CSF

G-CSF


Input: Although adverse reactions to protamine are reported infrequently and are usually mild, we recently observed the first fatal case of type I anaphylaxis resulting from protamine.

resulting

fatal case of type I anaphylaxis

protamine

protamine


Input: We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.

induced

six cases

six

parkinsonism

metoclopramide

metoclopramide


Input: Neutrophilic eccrine hidradenitis mimicking cutaneous vasculitis in a lupus patient: a complication of cyclophosphamide.

complication

a lupus patient

Neutrophilic eccrine hidradenitis

cyclophosphamide

lupus

cyclophosphamide


Input: Gliclazide-induced acute hepatitis.

induced

acute hepatitis

Gliclazide

Gliclazide


Input: A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation.

developed

A 16-year-old white male with acute biphenotypic leukemia

white

male

acute biphenotypic leukemia

eosinophilia myalgia syndrome

total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation

tryptophan

parenteral


Input: Subacute cholestatic hepatitis likely related to the use of senna for chronic constipation.

related to

Subacute cholestatic hepatitis

use of senna

senna

chronic constipation.


Input: Palmar-plantar erythrodysaesthesia (PPE) is an uncommon cutaneous complication of cytotoxic chemotherapy which generally presents as a painful erythema involving the palms and soles.

complication

Palmar-plantar erythrodysaesthesia (PPE)

an uncommon cutaneous complication

a painful erythema involving the palms and soles

cytotoxic chemotherapy

cytotoxic

chemotherapy


Input: We report a case of an 11-year-old boy who experienced an anaphylactic reaction after administration of bacitracin ointment.

experienced

an 11-year-old boy

boy

an anaphylactic reaction

after administration of bacitracin ointment

bacitracin


Input: The patient was found to have no motile sperm with a normal sperm count, while taking a dose of 400 mg/day of carbamazepine.

found

The patient

no motile sperm with a normal sperm count

400 mg/day of carbamazepine

400 mg/day

carbamazepine


Input: A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.

occurred

a patient with an history of depression with hypomanic rebounds

depression

hypomanic rebounds

A fatal pancytopenia

treated with levomepromazine, diazepam and lithium carbonate

a manic episode

levomepromazine

diazepam

lithium carbonate

levomepromazine

diazepam

lithium carbonate


Input: Oxatomide is an antiallergic drug used for the treatment of diseases mediated by type I allergy.

used

Oxatomide

diseases mediated by type I allergy

Oxatomide


Input: Toxic hepatitis induced by disulfiram in a non-alcoholic.

induced

a non-alcoholic

Toxic hepatitis

disulfiram

disulfiram


Input: Accordingly, camptocormia is a dose-dependent side effect of valproate.

effect

camptocormia

valproate

valproate


Input: The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia.

cause

leukopenia

long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency

long-term

adequately-dosed

AZA


Input: CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.

developed

65-year-old patient

confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome

chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram

following initiation of fentanyl

fentanyl

citalopram

chronically

fentanyl

citalopram


Input: Such a case induced by hypothyroidism complicating long-term therapy with amiodarone in a 45 year old woman with pre-excitation is presented.

complicating

a 45 year old woman with pre-excitation

45 year old

woman

hypothyroidism

long-term therapy with amiodarone

amiodarone

long-term

pre-excitation


Input: The diagnosis was based on the rapid onset of renal failure, presence of eosinophilia, skin rash, and characteristic renal biopsy finding, following the administration of ampicillin.

following

rapid onset of renal failure, presence of eosinophilia, skin rash, and characteristic renal biopsy

ampicillin

ampicillin


Input: 46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis.

developed

46-year-old woman

woman

painful ulcers over her lower abdomen in the form of reticulate erythema

injecting interferon beta-1b subcutaneously

interferon beta-1b

injecting

multiple sclerosis


Input: Lupus-like syndrome caused by 5-aminosalicylic acid in patients with inflammatory bowel disease.

caused

patients with inflammatory bowel disease

Lupus-like syndrome

5-aminosalicylic acid

inflammatory bowel disease

5-aminosalicylic acid


Input: Fatal acute tubular necrosis occurred in 1 patient in whom intravesical formalin was used to control massive persistent hemorrhage from radiation cystitis.

occurred

1 patient

acute tubular necrosis

intravesical formalin

massive persistent hemorrhage from radiation cystitis

intravesical

formalin


Input: The hypercalcemia responded to discontinuation of rhGH and a single dose of intravenous pamidronate disodium and has not recurred in 8 months of follow-up.

responded

has not recurred in 8 months of follow-up

discontinuation of rhGH and a single dose of intravenous pamidronate disodium

hypercalcemia

rhGH

pamidronate disodium

intravenous


Input: The administration of "sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.

followed

infant twins

infant

acute methemoglobinemia and severe anoxic metabolic acidosis

"sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol)

sweet spirits of nitre


Input: The authors describe three families in whom the occurrence of FVS in all the siblings strongly suggests hereditary susceptibility to valproic acid-induced adverse outcome.

susceptibility

three families

all the siblings

three

FVS

valproic acid-induced

valproic acid


Input: We hypothesize that capecitabine-induced headache is vascular in nature.

induced

headache

capecitabine

capecitabine


Input: A lupus-like syndrome associated with infliximab therapy.

associated

A lupus-like syndrome

infliximab

infliximab


Input: A case report of a patient with probable cisplatin and bleomycin-induced TMA is presented.

induced

a patient with probable cisplatin

TMA

bleomycin

bleomycin

probable cisplatin


Input: In some cases this seems to happen because spironolactone causes diarrhoea.

causes

diarrhoea

spironolactone

spironolactone


Input: Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.

observed

two children

two

children

Painful neutrophilic skin lesions

granulocyte colony-stimulating factor (G-CSF)

granulocyte colony-stimulating factor

idiopathic neutropenia


Input: Apparent central nervous system depression in infants after the use of topical brimonidine.

after

infants

infants

Apparent central nervous system depression

topical brimonidine

brimonidine

topical


Input: To our knowledge, this is the first report of insulin-induced lipohypertrophy with detailed histological examinations.

induced

lipohypertrophy

insulin

insulin


Input: Tigecycline-induced acute pancreatitis: case report and literature review.

induced

acute pancreatitis

Tigecycline

Tigecycline


Input: Polymyositis is a rare complication of interferon alpha treatment as a result of immune-modulating role of the drug itself.

complication of

Polymyositis

interferon alpha treatment

interferon alpha


Input: Sodium thiosulfate is a neutralizing agent for cisplatin that protects against renal damage.

protects

protects against renal damage

Sodium thiosulfate is a neutralizing agent for cisplatin

cisplatin

Sodium thiosulfate

renal damage

Sodium thiosulfate

cisplatin


Input: Anaphylactic reaction to bacitracin ointment.

reaction

Anaphylactic

bacitracin ointment

bacitracin


Input: Severe bleomycin lung toxicity: reversal with high dose corticosteroids.

toxicity:

Severe bleomycin lung toxicity

bleomycin

bleomycin


Input: CONCLUSIONS: Although mirtazapine offers clinicians a combination of strong efficacy and good safety, we suggest bearing SS in mind when prescribing this drug, especially in frail, elderly patients with underlying chronic conditions.

bearing

frail, elderly patients with underlying chronic conditions

elderly

underlying chronic conditions

SS

mirtazapine

mirtazapine


Input: Five cases of clindamycin-associated pseudomembranous colitis in leukaemic patients are reported.

associated

leukaemic patients

leukaemic

pseudomembranous colitis

clindamycin

clindamycin


Input: Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed acute vision loss and change of consciousness.

developed

he

he

acute vision loss and change of consciousness

intravitreal injection of bevacizumab (1.25 mg in 0.1 ml),

intravitreal injection

bevacizumab

1.25 mg in 0.1 ml


Input: The proposed cause of the nausea and anorexia was digoxin toxicity secondary to a drug-drug interaction with ciprofloxacin.

secondary

nausea and anorexia was digoxin toxicity

ciprofloxacin

ciprofloxacin

digoxin

digoxin

ciprofloxacin


Input: Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).

associated

the hemolytic-uremic syndrome (HUS)

Mitomycin C (MMC)

Mitomycin C


Input: Muscle biopsy revealed variation in muscle fiber size and few vacuolated fibers which were features of colchicine-induced myopathy.

induced

variation in muscle fiber size and few vacuolated fibers

myopathy

colchicine

colchicine


Input: We describe a patient who developed NEH on three separate occasions provoked by two different chemotherapeutic agents--cytarabine and mitoxantrone.

provoked

a patient

NEH

cytarabine and mitoxantrone

cytarabine

mitoxantrone

cytarabine

mitoxantrone


Input: Orofacial dyskinesia appeared 5 hours after methylphenidate administration, persisted for 10 hours, and had completely resolved within 2 days.

appeared

Orofacial dyskinesia

5 hours after methylphenidate

methylphenidate

5 hours after


Input: Present results suggested that coadministration of mexiletine increased blood tizanidine concentrations and enhanced tizanidine pharmacodynamics in terms of reduction in blood pressure and adverse symptoms.

enhanced

tizanidine pharmacodynamics in terms of reduction in blood pressure and adverse symptoms

coadministration of mexiletine increased blood tizanidine concentrations

mexiletine

tizanidine

mexiletine

tizanidine


Input: Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.

most likely

this patient

Bilateral acoustic (VIII) nerve palsy

neurotoxicity

vincristine

vincristine


Input: Acute leukopenia associated with silver sulfadiazine therapy.

associated

Acute leukopenia

silver sulfadiazine

silver sulfadiazine


Input: We describe two cases of PSVT that changed to non-sustained polymorphic ventricular tachycardia after administration of verapamil.

changed

two cases of PSVT

two

non-sustained polymorphic ventricular tachycardia

administration of verapamil.

verapamil

PSVT


Input: We described the occurrence of L-dopa-induced myoclonus and seizures in a case of parkinsonism with its SEPs findings.

induced

case of parkinsonism

myoclonus and seizures

L-dopa

L-dopa

parkinsonism


Input: Retrospectively, bucillamine was believed to be the cause of the giant hypertrophy because of its structural similarity to D-penicillamine, which was the subject of an abundance of reports of mammary hyperplasia.

cause of

giant hypertrophy

bucillamine

bucillamine

D-penicillamine


Input: We speculate that platelet activation induced by pFVIII may have contributed to thrombosis and suggest that pFVIII be used with caution in elderly patients with pre-existing cardiovascular risk factors.

contributed

thrombosis

pFVIII

pFVIII

cardiovascular


Input: Restoration of vancomycin susceptibility in Enterococcus faecalis by antiresistance determinant gene transfer.

by

Restoration of vancomycin susceptibility in Enterococcus faecalis

antiresistance determinant gene transfer

vancomycin


Input: Dental and gingival pain as side effects of niacin therapy.

side effects

Dental and gingival pain

niacin

niacin


Input: We describe a case of significant elevation of serum transaminases in a patient treated with 6-TG for a flare of Crohn's disease.

elevation

a patient

significant elevation of serum transaminases

Crohn's disease


Input: A patient developed transient, acute myopia while on isotretinoin (Accutane) therapy for acne.

developed

acne

A patient

transient, acute myopia

isotretinoin (Accutane)

acne

isotretinoin


Input: CONCLUSIONS: The pathogenesis of methotrexate-induced papular eruption in collagen vascular diseases may suggest cutaneous small-vessel vasculitis.

induced

papular eruption

methotrexate

collagen vascular diseases

methotrexate


Input: Aminophylline hypersensitivity apparently due to ethylenediamine.

due

Aminophylline hypersensitivity

ethylenediamine

ethylenediamine


Input: The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.

demonstrated

this 58-year-old female

female

leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis

antithyroid therapy with 20 mg methimazole daily

20 days after

methimazole

20 mg

daily


Input: In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.

induced

patient

hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation

ciprofloxacin

ciprofloxacin


Input: Excluding other causes, Pentasa-associated pancytopenia was considered.

associated

pancytopenia

Pentasa

Pentasa


Input: RESULTS: A patient developed a bilaterally symmetric bull's-eye maculopathy 45 years after taking quinacrine for 18 months as prophylaxis against malaria.

developed

A patient

bilaterally symmetric bull's-eye maculopathy

45 years after taking quinacrine for 18 months

45 years after

18 months

quinacrine

malaria


Input: Possible digoxin toxicity associated with concomitant ciprofloxacin therapy.

associated

digoxin toxicity

ciprofloxacin

digoxin

ciprofloxacin

digoxin

ciprofloxacin

digoxin


Input: The exophthalmos improved dramatically within 72 hours of the withdrawal of lithium.

improved

within 72 hours of the withdrawal of lithium

exophthalmos

lithium

within 72 hours


Input: We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21.

following

two cases of

cardiac patients with trisomy 21

two

cardiac

trisomy 21

neutropenia

captopril use

captopril


Input: We report a case of hyponatremia associated with a grand mal seizure in a 28 month-old child after intra-nasal desmopressin administration for high fluid intake with nocturnal enuresis.

after

a 28 month-old child

28 month-old child

hyponatremia associated with a grand mal seizure

intra-nasal desmopressin administration

high fluid intake with nocturnal enuresis

desmopressin

intra-nasal


Input: He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.

developed

He

He

fever, nausea, diarrhea, and malaise

Pentasa

Pentasa

third day


Input: Livedo reticularis associated with interferon alpha therapy in two melanoma patients.

associated

two melanoma patients

two

Livedo reticularis

interferon alpha therapy

melanoma

interferon alpha


Input: A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.

developed

A 60-year-old woman with diabetes mellitus (type 2)

woman

an acute icteric hepatitis-like illness

6 weeks after the initiation of gliclazide therapy

6 weeks

gliclazide

diabetes mellitus (type 2)


Input: Thus cabergoline may cause similar pleuropulmonary abnormalities to bromocriptine.

cause

pleuropulmonary abnormalities

bromocriptine

cabergoline

cabergoline

bromocriptine


Input: Although the existence of an acute pericarditis or an acute myocarditis as possible causes of the ST elevation cannot be fully ruled out, the sudden onset, prominent magnitude, and brief duration of the ST elevation are perhaps more indicative of an acute ischemic event, possibly related to a transient coronary vasoconstriction induced by the dopamine infusion.

induced

transient coronary vasoconstriction

dopamine

dopamine


Input: Acute sensorineural hearing loss following intravenous ketoralac administration.

following

Acute sensorineural hearing loss

intravenous ketoralac

ketoralac

intravenous


Input: Trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6.

induced

hypersensitivity syndrome associated with reactivation of human herpesvirus-6

Trimethoprim-sulfamethoxazole

Trimethoprim-sulfamethoxazole


Input: A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone.

developed

A patient

pulmonary fibrosis

nabumetone

nabumetone


Input: To report a case of increased international normalized ratio (INR) in a geriatric patient receiving warfarin and ropinirole.

case

a geriatric patient

geriatric

increased international normalized ratio (INR)

warfarin and ropinirole

warfarin

ropinirole

ropinirole

warfarin


Input: There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.

with

ocular toxicity

ethambutol

ethambutol


Input: k bipolar manic-depressive patient, developed while on lithium prophylaxis, akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia.

developed

k bipolar manic-depressive patient

bucco-linguo-masticatory dyskinesia

akathisia

lithium

at therapeutic serum lithium levels

k bipolar manic-depressive

lithium


Input: We describe a patient who had a systemic allergic contact dermatitis to 8-MOP develop during her second course of PUVA treatment for psoriasis.

develop

a patient

systemic allergic contact dermatitis to 8-MOP

PUVA

psoriasis

PUVA


Input: Seizures were treated with diazepam.

treated

diazepam

Seizures

diazepam


Input: Paradoxical seizures in phenytoin toxicity.

seizures

Paradoxical seizures

phenytoin toxicity

phenytoin


Input: CASE SUMMARY: Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum.

developed

Two children with attention deficit disorder

Two

children

fixed drug eruption of the scrotum

methylphenidate as a simple drug

methylphenidate

attention deficit disorder


Input: While the patient was receiving both drugs, platelet aggregation studies revealed less platelet inhibition than would be expected in a patient not taking a concomitant inducer of ticagrelor metabolism.

revealed

a patient

less platelet inhibition than would be expected

taking a concomitant inducer of ticagrelor metabolism.

ticagrelor

inducer of ticagrelor metabolism

inducer of ticagrelor metabolism

ticagrelor


Input: Metformin-associated lactic acidosis precipitated by diarrhea.

associated

lactic acidosis

Metformin

Metformin


Input: To date, only 1 death attributable to risperidone overdose has been reported.

attributable

death

risperidone overdose

risperidone

overdose


Input: Systemic allergic contact dermatitis to 8-methoxypsoralen (8-MOP).

to

Systemic allergic contact dermatitis

8-methoxypsoralen (8-MOP)


Input: A case of a 21-year-old woman who had developed mild hepatotoxicity while receiving choline magnesium trisalicylate therapy is described.

receiving

a 21-year-old woman

woman

mild hepatotoxicity

choline magnesium trisalicylate

choline magnesium trisalicylate


Input: Early ritonavir-induced maculopapular eruption.

induced

maculopapular eruption

ritonavir

ritonavir


Input: In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal.

cause

our patient

his renal and hepatic function were normal

his

myopathy

therapeutic doses of colchicine for FMF

colchicine

FMF

therapeutic doses


Input: Thrombocytosis induced by enoxaparin has been reported as a rare adverse effect of this medication in adults.

induced

Thrombocytosis

enoxaparin

enoxaparin


Input: A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane.

developed

A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs

woman

a B-cell lymphoma of the lip

4 1/2 years of treatment with razoxane

following 4 1/2 years

razoxane

acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs


Input: The evidence of high plasmatic levels of CBZ and the absence of other aetiologic factors lead the authors to conclude that the overdose of CBZ could have represented the precipitating of the episode of acute pancreatitis.

precipitating

acute pancreatitis

overdose of CBZ

CBZ


Input: In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma.

induced

a patient with gallbladder metastatic adenocarcinoma

pulmonary toxicity

gemcitabine

gallbladder metastatic adenocarcinoma

gemcitabine


Input: Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years.

developed

a psoriatic patient

Progressive interstitial fibrosis with roentgenographic honeycombing

a regimen of methotrexate for 18 years

methotrexate

18 years

psoriatic


Input: In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.

developed

one patient

one

gangrene

bleomycin and vincristine/vinblastine

bleomycin

vincristine

vinblastine

bleomycin

vincristine

vinblastine


Input: These multiple overlapping factors probably lead to rhabdomyolysis in a minority of patients receiving vasopressin infusion.

lead

patients

rhabdomyolysis

vasopressin

vasopressin

infusion


Input: Due to the increasing use of TMP-SMX in children, clinicians should be aware of this potentially life-threatening, immunemediated hypersensitivity reaction.

reaction.

children

children

life-threatening, immunemediated hypersensitivity

TMP-SMX

TMP-SMX


Input: Given that discontinuation of nitrofurantoin and introduction of methylprednisolon therapy significantly lowered liver enzyme levels, restoring most of them to normal, we concluded that this was probably the case of toxic liver damage caused by nitrofurantoin.

caused

toxic liver damage

nitrofurantoin

nitrofurantoin


Input: Slow acetylators, who comprise roughly 50% of the South African population, are likely to develop clinical and biochemical features of phenytoin toxicity when this drug is given together with antituberculosis therapy.

develop

Slow acetylators

Slow acetylators

clinical and biochemical features of phenytoin toxicity

phenytoin

together with antituberculosis

antituberculosis

phenytoin

phenytoin

antituberculosis


Input: Therefore there is the potential for significant concentration-related adverse effects when phenytoin is coadministered with other CYP2C9 substrates.

potential

significant concentration-related adverse effects

phenytoin

other CYP2C9 substrates

phenytoin

other CYP2C9 substrates

phenytoin

other CYP2C9 substrates


Input: Putaminal infarct in methanol intoxication: case report and role of brain imaging studies.

intoxication:

Putaminal infarct in methanol intoxication

methanol

methanol


Input: Progressive interstitial lung disease from prolonged methotrexate therapy.

from

Progressive interstitial lung disease

prolonged methotrexate therapy

prolonged

methotrexate


Input: The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity.

developed

a child

child

systemic iron toxicity

a large dose of intravenous iron sucrose

iron sucrose

16 mg/kg

3 hours


Input: We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin.

developed

a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin

a peculiar dermnatitis in the irradiated field

exposed to subsequent chemotherapy with oxaliplatin

advanced colonic carcinoma

concomitant chemoirradiation

oxaliplatin

oxaliplatin


Input: Recombinant human interferon-alpha has been used in the treatment of several cancers, but there have been several reports that it may exacerbate psoriasis or trigger off its onset.

trigger

exacerbate psoriasis

Recombinant human interferon-alpha

Recombinant human interferon-alpha

cancers


Input: This is the first case of HBV reactivation occurring during the year following rituximab monotherapy in the absence of any other immunosuppressive factor.

occurring

HBV reactivation

the year following rituximab monotherapy in the absence of any other immunosuppressive factor

rituximab

year following


Input: Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis.

during

Systemic lupus erythematosus

penicillamine therapy

penicillamine

rheumatoid arthritis.


Input: In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient.

following

this patient

dermatologic toxicity

an 'allergic' or acute hypersensitivity reaction

a single low dose of the drug

MTX

MTX

single low dose


Input: Erosion of psoriatic plaques after chronic methotrexate administration.

after

Erosion of psoriatic plaques

methotrexate

methotrexate


Input: Cardiac decompensation following verapamil therapy in infants with supraventricular tachycardia.

following

infants with supraventricular tachycardia

infants

Cardiac decompensation

verapamil therapy

supraventricular tachycardia

verapamil


Input: We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents.

associated

perinatally HIV-infected adolescents

adolescents

nephrotoxicity

tenofovir (TDF)

tenofovir

HIV


Input: RESULTS: Including our own patient, a total of 26 cases of gemcitabine-associated HUS were identified.

associated

HUS

gemcitabine

gemcitabine


Input: Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.

induced

pulmonary toxicity

respiratory symptoms

docetaxel

docetaxel


Input: In this article, the authors report a 7-year-old male patient who presented with orofacial and limb dyskinesia after his first dose of methylphenidate treatment for a diagnosis of attention-deficit/hyperactivity disorder; he was also receiving sodium valproate treatment for epilepsy.

after

a 7-year-old male patient

male

orofacial and limb dyskinesia

first dose of methylphenidate

attention-deficit/hyperactivity disorder

first dose

methylphenidate


Input: The first case concerns a 70-year-old man who developed severe aplastic anemia 7 weeks after treatment with 500 mg of ticlopidine daily.

developed

70-year-old man

man

severe aplastic anemia

7 weeks after treatment with 500 mg of ticlopidine daily

7 weeks

500 mg

ticlopidine

daily


Input: CASE REPORT: A six-year-old boy with transfusion-dependent beta-thalassaemia developed a unilateral hearing loss shortly after commencing desferrioxamine therapy.

developed

A six-year-old boy with transfusion-dependent beta-thalassaemia

six-year-old

boy

a unilateral hearing loss

commencing desferrioxamine therapy

transfusion-dependent beta-thalassaemia

shortly after

desferrioxamine


Input: Syncope in a 65-year-old woman after nitrate ingestion.

after

a 65-year-old woman

woman

Syncope

nitrate ingestion

nitrate

ingestion


Input: Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment.

appeared

longitudinal melanonychia and the multiple skin cancers

approximately 6 months of hydroxyurea treatment

6 months

hydroxyurea


Input: Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.

associated with

Multifocal inflammatory leukoencephalopathy

levamisole therapy

levamisole


Input: The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.

during

cutaneous vasculitis

propylthiouracil

propylthiouracil


Input: Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion.

induced

radiation recall reaction resulting in hemodynamically significant pericardial effusion

gemcitabine

gemcitabine


Input: OBJECTIVE: To describe a case of cefazolin-induced leukopenia in a critically ill patient who developed this adverse reaction upon rechallenge with cefoxitin.

induced

a critically ill patient

critically ill

leukopenia

cefazolin

cefazolin


Input: The second patient suffered from high blood pressure, which was controlled with beta-blocker drugs.

controlled

The second patient suffered from high blood pressure

beta-blocker drugs

high blood pressure

beta-blocker drugs


Input: The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months.

induced

The female patient

female

agranulocytosis

clozapine in a daily dose of 400 mg

after 2 months

2 months

400 mg

daily

clozapine


Input: We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine.

during

a case

interstitial pulmonary disease

lymphocytic colitis

ticlopidine

ticlopidine


Input: Increased ocular pressure in two patients with narrow angle glaucoma treated with venlafaxine.

in

two patients with narrow angle glaucoma

narrow angle glaucoma

two

Increased ocular pressure

venlafaxine

venlafaxine