Input: OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions.

induced

lipoatrophies

insulin

insulin

diabetic


Input: An evaluation of ovarian structure and function should be considered in women of reproductive age being treated with valproate for epilepsy, especially if they develop menstrual cycle disturbances during treatment.

develop

women of reproductive age

women

reproductive age

menstrual cycle disturbances

valproate for epilepsy

valproate

epilepsy


Input: Phenobarbital hepatotoxicity in an 8-month-old infant.

in

an 8-month-old infant

8-month-old infant

hepatotoxicity

Phenobarbital

Phenobarbital


Input: The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.

following

Balint syndrome with irreversible posterior leukoencephalopathy on MRI

intrathecal methotrexate and cytarabine

intrathecal

methotrexate

cytarabine

cytarabine

methotrexate


Input: According to the Naranjo probability scale, flecainide was the probable cause of the patient's delirium; the Horn Drug Interaction Probability Scale indicates a possible pharmacokinetic drug interaction between flecainide and paroxetine.

cause

the patient

delirium

flecainide

flecainide

flecainide

paroxetine

flecainide

paroxetine


Input: Contact dermatitis due to budesonide: report of five cases and review of the Japanese literature.

due

Contact dermatitis

budesonide

budesonide


Input: Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.

following

a Japanese patient with vivax malaria

Japanese

Prolongation of the QT interval

halofantrine

vivax malaria

halofantrine


Input: We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.

related

three cases

three

severe hepatotoxicity

benzarone

benzarone


Input: Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported.

symptoms of

Four patients

Four

hypersensitivity syndrome

antiepileptic drug (AED)

during therapy with carbamazepine

antiepileptic drug (AED)

carbamazepine


Input: Minocycline as a cause of drug-induced autoimmune hepatitis.

induced

autoimmune hepatitis

Minocycline

Minocycline


Input: Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis.

after

Secondary acute myeloid leukemia

etoposide therapy

etoposide

haemophagocytic lymphohistiocytosis


Input: Allergic contact angioedema to benzoyl peroxide.

to

Allergic contact angioedema

benzoyl peroxide

benzoyl peroxide


Input: A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.

develop

A 60-year-old white man with chronic bronchitis

white

man

chronic bronchitis

acute respiratory failure and metabolic acidosis

methazolamide (Neptazane)

methazolamide

ophthalmologic problem

four days after


Input: L-DOPA-induced excessive daytime sleepiness in PD: a placebo-controlled case with MSLT assessment.

induced

daytime sleepiness

L-DOPA

DOPA


Input: CONCLUSIONS: It is probable that foscarnet contributed to the electrolyte disorders and symptomatology in this patient.

contributed

this patient

electrolyte disorders and symptomatology

foscarnet

foscarnet


Input: Acute drug induced hepatitis due to erlotinib.

due

Acute drug induced hepatitis

erlotinib

erlotinib


Input: We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.

after

3 diabetic patients

intolerable dizziness followed by nausea and vomiting

an initial administration of the alpha-glucosidase inhibitor, voglibose

diabetic

voglibose


Input: Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.

induced

the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA

3 out of 5

pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA

pulmonary toxicity

MTX

MTX


Input: Acute esmolol toxicity may be self-limiting because of its extremely short half-life.

be

toxicity

esmolol

esmolol


Input: The association with prolonged unopposed estrogen-like stimulation with tamoxifen as a possible factor in the development of ovarian endometrioid carcinoma is discussed.

with

development of ovarian endometrioid carcinoma

prolonged unopposed estrogen-like stimulation with tamoxifen

prolonged

tamoxifen


Input: The other woman had rheumatoid arthritis and developed acute tubular necrosis after treatment with gentamicin and cefoxitin.

developed

The other woman had rheumatoid arthritis

woman

acute tubular necrosis

gentamicin and cefoxitin

rheumatoid arthritis

gentamicin

cefoxitin

gentamicin

cefoxitin


Input: One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).

had

One patient

One

marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia)

clindamycin

clindamycin


Input: A MEDLINE search (1966-January 2009) revealed one in vivo pharmacokinetic study on the interaction between flecainide, a CYP2D6 substrate, and paroxetine, a CYP2D6 inhibitor, as well as 3 case reports of flecainide-induced delirium.

induced

3 case reports

delirium

flecainide

flecainide


Input: As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.

develops.

patients

diarrhoea

spironolactone

spironolactone


Input: When these cells are exposed to nicotinic acid, an exaggerated immune response is produced that may lead to pain, redness, and swelling at the injection site.

produced

exaggerated immune response

pain, redness, and swelling at the injection site

nicotinic acid

nicotinic acid


Input: A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy.

reported

a 32-year-old man diagnosed with schizophrenia

man

heatstroke

clozapine monotherapy

clozapine

schizophrenia


Input: Paraplegia following intrathecal cytosine arabinoside.

following

Paraplegia

intrathecal cytosine arabinoside

intrathecal

cytosine arabinoside


Input: Cimetidine-induced fever.

induced

fever

Cimetidine

Cimetidine


Input: This case report illustrates the neurotoxicity unique to HDARAC.

to

This case

neurotoxicity unique

HDARAC

HDARAC


Input: Agranulocytosis associated with ticlopidine: a possible benefit with filgastim.

associated

Agranulocytosis

ticlopidine

ticlopidine


Input: Since SS is a clinical diagnosis, heightened clinician awareness of the possibility of SS among patients receiving SSRI or mirtazapine in combination with opioids may lead to earlier detection and avoidance of potentially lethal consequences.

lead to

patients

potentially lethal consequences

SSRI or mirtazapine in combination with opioids

SSRI

mirtazapine

opioids

mirtazapine

opioids

SSRI


Input: The mechanism by which sunitinib induces gynaecomastia is thought to be associated with an unknown direct action on breast hormonal receptors.

induces

gynaecomastia

sunitinib

sunitinib


Input: Some patients develop hypersensitivity rash in response to HCQ.

develop

Some patients

Some

hypersensitivity rash

HCQ

HCQ


Input: To report a case of serotonin toxicity, presenting in the postoperative period, caused by an interaction between paroxetine (a selective serotonin reuptake inhibitor, SSRI) and fentanyl (a phenylpiperidine opioid).

caused

serotonin toxicity

paroxetine

fentanyl

paroxetine

fentanyl

paroxetine

fentanyl


Input: However, to our knowledge, in newborns there have been no reported cases to date of thrombocytosis induced by enoxaparin.

induced

newborns

newborns

thrombocytosis

enoxaparin

enoxaparin


Input: The case presented here documents adverse cardiac effects in a 28-year-old man who intentionally ingested 24 mg of risperidone--4 times the recommended dose.

ingested

28-year-old man

man

adverse cardiac effects

24 mg of risperidone

24 mg

risperidone


Input: Anaphylaxis to cisplatin following nine previous uncomplicated cycles.

to

Anaphylaxis

cisplatin following nine previous uncomplicated cycles

cisplatin

nine previous uncomplicated cycles


Input: To the best of the authors' knowledge, this is the first reported case of Propecia-associated cataract.

associated

cataract

Propecia

Propecia


Input: Serotonin syndrome caused by interaction between citalopram and fentanyl.

caused

Serotonin syndrome

citalopram and fentanyl

citalopram

fentanyl

citalopram

fentanyl


Input: We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.

induced

parkinsonian patients

parkinsonian

diphasic dyskinesias

levo-dopa

levo-dopa


Input: This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.

after

acute lung injury

persistent despite halofantrine therapy

administration of mefloquine for a low-level Plasmodium falciparum malaria

halofantrine therapy

within hours

mefloquine

halofantrine

low-level Plasmodium falciparum malaria


Input: Warfarin-associated bleeding generally is considered deleterious; however, in our patient it unmasked an early stage of colon cancer and thus may have saved the patient's life.

associated

bleeding

Warfarin

Warfarin


Input: The clinical use of itraconazole in patients receiving multiple doses of oxycodone for pain relief may increase the risk of opioid-associated adverse effects.

increase

patients

opioid-associated adverse effects

itraconazole

receiving multiple doses of oxycodone

pain relief

oxycodone

itraconazole

multiple doses

itraconazole

oxycodone


Input: Three cases of gold-related neuropathy are reported.

related

Three cases

Three

neuropathy

gold

gold


Input: We report the case of a man, treated with mesalazine for Crohn's disease who developed drug-induced pericarditis.

developed

a man

man

drug-induced pericarditis

mesalazine

Crohn's disease

mesalazine


Input: We report the occurrence of spontaneous intracranial bleeding in an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A who was receiving amprenavir (APV).

occurrence

an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A

spontaneous intracranial bleeding

amprenavir (APV)

immunodeficiency virus (HIV)-infected adolescent with hemophilia A

amprenavir (APV)


Input: Under the suspicion of amiodarone-induced acute pancreatitis, amiodarone was substituted by propafenone.

induced

acute pancreatitis

amiodarone

amiodarone


Input: Evidence is shown in this report that adenosine was associated with dangerous worsening of arrhythmia in patients with atrial flutter.

associated

patients with atrial flutter

dangerous worsening of arrhythmia

adenosine

atrial flutter.

adenosine


Input: Salicylate hepato toxicity in rheumatic fever.

toxicity

hepato toxicity

Salicylate

rheumatic fever

Salicylate


Input: A case of serotonin syndrome that developed during concurrent linezolid and fluoxetine is presented.

developed

serotonin syndrome

concurrent linezolid and fluoxetine

linezolid

fluoxetine

linezolid

fluoxetine


Input: Herein we report four patients who underwent liver transplantation and developed neutropenia while receiving MMF.

developed

four patients who underwent liver transplantation

four

liver transplantation

neutropenia

MMF

MMF


Input: A study of in vitro reactivity to L-T4, as assessed by peripheral blood lymphocyte transformation, was carried out in a patient with Hashimoto's disease who developed leukopenia during treatment with L-T4.

developed

a patient with Hashimoto's disease

leukopenia

Hashimoto's disease


Input: Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent symptoms other than transient pallor.

receiving

patients

Methemoglobinemia

transient pallor

dapsone therapy

dapsone


Input: During the first treatment, dysarthria and ataxia were seen after completion of the patient's eighth and final dose of HDARAC.

seen

the patient's

dysarthria and ataxia

HDARAC

HDARAC


Input: Four weeks earlier she had developed hepatopathy during a regimen of carbamazepine, lynestrenol and sodium valproate.

developed

she

she

hepatopathy

carbamazepine, lynestrenol and sodium valproate

carbamazepine

lynestrenol

sodium valproate


Input: We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.

occur

asterixis

even at low or moderate dosage levels

certain drugs as lithium or clozapine are used in combination with CBZ

CBZ

lithium

clozapine

low or moderate dosage

CBZ

lithium

CBZ

clozapine


Input: We report here a rare case of pleuropericarditis due to methotrexate.

due

a rare case

pleuropericarditis

methotrexate

methotrexate


Input: A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.

induced

hepatitis with mononucleosis

phenytoin

phenytoin


Input: We also discuss whether screening for DPD deficiency is warranted to identify patients at risk for severe toxicities from 5-FU treatment.

risk

patients

severe toxicities

5-FU treatment


Input: We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin.

undergoing

a 16-year-old girl with acute myelogenous leukemia (AML)

girl

reversible encephalopathy syndrome

consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin

acute myelogenous leukemia

idarubicin

BH-AC

idarubicin

BH-AC


Input: Concurrent use of vismodegib and warfarin was deemed the probable cause of acute INR elevation in this case, suggesting the need for close monitoring of INR values in patients receiving this combination of drugs.

cause

acute INR elevation

vismodegib and warfarin

vismodegib

warfarin

vismodegib

warfarin


Input: Captopril is an angiotensin-converting enzyme (ACE) inhibitor and their cutaneous side-effects are documented, but little has been published concerning the usefulness of patch test when they occur.

documented,

cutaneous side-effects

Captopril

Captopril


Input: High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn.

in

a pregnant woman with Crohn's disease

pregnant

woman

adrenal suppression in her newborn

High-dose methylprednisolone

Crohn's disease

High-dose

methylprednisolone


Input: Cardiac hypersensitivity and myopericarditis have been reported during long-term treatment with mesalazine.

reported

Cardiac hypersensitivity and myopericarditis

long-term treatment with mesalazine

long-term

mesalazine


Input: It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.

represent

cerebral atrophy

ACTH

ACTH

ACTH


Input: Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia.

induced

polymorphic ventricular tachycardia

verapamil

paroxysmal supraventricular tachycardia

verapamil


Input: Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate.

after

Fatal acute encephalomyelitis

single dose of intrathecal methotrexate

single dose

intrathecal

methotrexate


Input: The authors report one case of incomplete posterior hyaloid detachment (PHD) following intravitreal pegaptanib to treat DME.

following

one case

incomplete posterior hyaloid detachment (PHD)

intravitreal pegaptanib

intravitreal

pegaptanib

DME


Input: Pulmonary edema as a delayed complication of ritodrine therapy.

complication

Pulmonary edema

ritodrine

ritodrine


Input: Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.

following

Carbamazepine toxicity

Oxybutynin and Dantrolene

Oxybutynin

Dantrolene

Dantrolene

Oxybutynin


Input: Multiple seizures after bupropion overdose in a small child.

after

a small child

small child

Multiple seizures

bupropion overdose

bupropion

overdose


Input: Sorafenib, a multitargeted kinase inhibitor used for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinomas, received FDA approval in 2005.

treatment

Sorafenib

a multitargeted kinase inhibitor

Sorafenib

unresectable hepatocellular carcinoma

advanced renal cell carcinomas


Input: Triiodothyronine-induced thyrotoxicosis in ophthalmic Graves disease.

induced

thyrotoxicosis

Triiodothyronine

ophthalmic Graves

Triiodothyronine


Input: Bleomycin induced hyperpigmentation with yolk sac tumor.

induced

hyperpigmentation with yolk sac tumor

Bleomycin

Bleomycin


Input: PURPOSE: To describe bilateral corneal endothelial dysfunction in a patient with Parkinson disease who was treated with long-term amantadine.

in

a patient with Parkinson disease

bilateral corneal endothelial dysfunction

long-term amantadine

Parkinson disease

amantadine

long-term


Input: A case of severe acute hepatitis caused by cyproterone acetate in a 71 year old man with prostatic carcinoma is reported with a review of the literature on hepatic reactions to this drug.

caused

a 71 year old man with prostatic carcinoma

71 year old

man

acute hepatitis

cyproterone acetate

cyproterone acetate

prostatic carcinoma


Input: Insulin-dependent diabetes mellitus associated with danazol.

associated

Insulin-dependent diabetes mellitus

danazol

danazol


Input: CONCLUSIONS: Topical brimonidine may be associated with central nervous system depression in infants.

associated

infants

infants

central nervous system depression

Topical brimonidine

brimonidine

Topical


Input: Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome.

associated

a patient with the LEOPARD syndrome

pneumonitis with acute respiratory failure

Flecainide

Flecainide

LEOPARD syndrome.


Input: Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis.

in

a child

child

Seizure with hyponatremia

desmopressin

desmopressin

nocturnal enuresis


Input: Risks and benefits of co-treatment should be carefully considered and therapeutic alternatives to NSAIDs should be recommended to patients with central DI in order to improve DDAVP safety.

recommended

patients with central DI

in order to improve DDAVP safety

therapeutic alternatives to NSAIDs

central DI

NSAIDs


Input: She had been treated by Carbamazepine 1000 mg/day for neuropathic pain for 2 years without clinical or laboratory signs of toxicity.

treated

She

Carbamazepine 1000 mg/day

neuropathic pain

Carbamazepine

1000 mg/day

2 years


Input: The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.

given

hepatotoxicity developed

vincristine and actinomycin D

vincristine

actinomycin D

vincristine

actinomycin D


Input: After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.

associated

confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension

second dose of metoclopramide

metoclopramide


Input: We report the first case of tuberculous uveitis due to etanercept.

due to

tuberculous uveitis

etanercept

etanercept


Input: Acute hyperphosphatemia caused by sodium phosphate enema in a patient with liver dysfunction and chronic renal failure.

caused

a patient with liver dysfunction and chronic renal failure

liver dysfunction and chronic renal failure

Acute hyperphosphatemia

sodium phosphate enema

sodium phosphate

enema


Input: We discuss the association between carbamazepine and hyponatremia and the causes of hyponatremia after cardiopulmonary bypass.

association

hyponatremia

carbamazepine

carbamazepine


Input: Use of the Naranjo adverse drug reaction probability algorithm indicated a probable relationship between serotonin syndrome and treatment with lithium and venlafaxine.

a probable relationship between

serotonin syndrome

treatment with lithium and venlafaxine

lithium

venlafaxine

lithium

venlafaxine


Input: The exact mechanism of IVIG-associated acute renal failure remains unclear.

associated

acute renal failure

IVIG

IVIG


Input: We report on 7 patients (2 women, 5 men) with chronic renal failure, who developed under a high dosage of the new diuretic muzolimine (range 240 to 1440 mg per day) fatal neuromyeloencephalopathy.

developed

7 patients (2 women, 5 men) with chronic renal failure

chronic renal failure

fatal neuromyeloencephalopathy

a high dosage of the new diuretic muzolimine (range 240 to 1440 mg per day)

diuretic muzolimine

per day

range 240 to 1440 mg


Input: Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication.

developed

Two renal transplant patients

Two

renal transplant

anemia

enalapril medication

hypertension

enalapril


Input: Sotalol-induced bradycardia reversed by glucagon.

reversed

glucagon

Sotalol-induced bradycardia

glucagon


Input: The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.

development

cutaneous ecchymosis

a sudden fall in hemoglobin

diffuse subfascial hematoma

alteplase

alteplase


Input: We report a case of papillary necrosis in a patient treated with indinavir.

treated

a patient

papillary necrosis

indinavir

indinavir


Input: Generalized maculopapular and papular purpuric eruptions are perhaps the most common thionamide-induced reactions.

induced

Generalized maculopapular and papular purpuric eruptions

reactions

thionamide

thionamide


Input: Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.

due

children

children

intoxication

Imidazoline

overdose or accidental ingestion but also after normal therapeutic usage

ingestion

overdose or accidental

but also after normal therapeutic usage


Input: A 50-year-old diabetic and hypertensive male patient is reported who had ticlopidine-induced marrow aplasia partially responsive to colony-stimulating factors and corticosteroids, but experienced complete recovery with cyclosporine.

induced

50-year-old diabetic and hypertensive male patient

diabetic and hypertensive

male

marrow aplasia

ticlopidine

ticlopidine


Input: A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.

developed

A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma

hereditary retinoblastoma

cerebral edema and brainstem herniation

a single dose of intravenous methotrexate

intracranial osteosarcoma

a single dose

intravenous

methotrexate


Input: Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril.

following

Neutropenia

the angiotensin-converting enzyme (ACE) inhibitor, captopril

captopril


Input: INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.

after

patient

severe cerebral swelling and raised intracranial pressure (ICP)

intoxication

sodium valproic acid (VPA)

sodium valproic acid


Input: Lithium therapy was discontinued because of poor compliance to the medication and intolerable polyuria.

because

polyuria

Lithium


Input: Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss.

cause

sensorineural hearing loss

PAN and methotrexate

PAN

methotrexate

PAN

methotrexate


Input: CONCLUSION: A 26-year-old man with bipolar disorder developed hyperammonemia three weeks after initiating carbamazepine therapy.

developed

A 26-year-old man with bipolar disorder

man

hyperammonemia

three weeks after initiating carbamazepine therapy

three weeks

carbamazepine

bipolar disorder


Input: We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects.

developed

two adults

two

adults

behavioural side effects

gabapentin (GBP)

gabapentin


Input: Atrial fibrillation was induced by diltiazem in two patients and verapamil induced syncope in one patient.

induced

two patients

two

Atrial fibrillation

diltiazem

diltiazem


Input: We can conclude that in this case, as in many others, akathisia as a possible adverse effect of psychopharmacs was very hard to identify.

adverse effect

this case

akathisia

psychopharmacs

psychopharmacs


Input: Although HAART is very important in the treatment of HIV, its side effects are responsible for patients' non-adherence to medications.

side effects

patients

non-adherence to medications

HAART

HIV

HAART


Input: A case of acute subdural haematoma originating spontaneously from an angiomatous meningioma in a patient receiving prophylactic aspirin therapy is presented.

presented.

an angiomatous meningioma in a patient

acute subdural haematoma

aspirin

aspirin


Input: Long known to psychiatrists, monoamine oxidase inhibitors (MAOIs) and complications of their use may be unfamiliar to medical and surgical practitioners who may thus unwittingly precipitate a hypertensive crisis or serotonin syndrome.

precipitate

hypertensive crisis or serotonin syndrome

monoamine oxidase inhibitors (MAOIs)

monoamine oxidase inhibitors


Input: According to the Naranjo adverse drug reaction probability scale, the likelihood that temozolomide was responsible for the adverse drug reaction of fever was probable (score of 6).

adverse drug reaction

fever

temozolomide

temozolomide


Input: OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy.

related

women with epilepsy

women

reproductive endocrine disorders

valproate

valproate

epilepsy


Input: Alprazolam-induced mania: two clinical cases.

induced

two clinical cases

two

mania

Alprazolam

Alprazolam


Input: Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.

associated with

Bronchiolitis obliterans organising pneumonia

use of nitrofurantoin

nitrofurantoin


Input: To our knowledge, this recurrence of amiodarone pulmonary toxicity has not been reported previously.

toxicity

pulmonary toxicity

amiodarone

amiodarone


Input: A patient treated with itraconazole (ITCZ) under the diagnosis of Aspergillus flavus-induced chronic hypertrophic pachymeningitis is presented.

treated

A patient

itraconazole (ITCZ)

itraconazole

Aspergillus flavus-induced chronic hypertrophic pachymeningitis


Input: Severe autoimmune hemolytic anemia following rituximab therapy in a patient with a lymphoproliferative disorder.

following

a patient with a lymphoproliferative disorder

Severe autoimmune hemolytic anemia

rituximab therapy

rituximab

lymphoproliferative disorder


Input: The renal consequences of indinavir-associated nephrotoxicity are uncertain.

associated

nephrotoxicity

indinavir

indinavir


Input: BACKGROUND: reports on delated cutaneous reactions to captopril have been seldom reported.

reported.

delated cutaneous reactions

captopril

captopril


Input: Bismuth subsalicylate 30 mL every 4 hours was prescribed for diarrhea.

prescribed

Bismuth subsalicylate 30 mL every 4 hours

Bismuth subsalicylate

30 mL

every 4 hours

diarrhea


Input: A drug interaction between the alpha(2)-adrenergic agonist medetomidine and lignocaine is suspected and highlights the potential for seizures following the subcutaneous administration of relatively large doses of lignocaine under medetomidine sedation.

following

seizures

subcutaneous administration of relatively large doses of lignocaine under medetomidine sedation

lignocaine

medetomidine

subcutaneous

medetomidine

lignocaine


Input: Oesophageal ulceration due to emepronium bromide.

due to

Oesophageal ulceration

emepronium bromide

emepronium bromide


Input: Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.

Development

sarcoidosis

interferon alpha 2b and ribavirin

interferon alpha 2b

ribavirin

chronic hepatitis C

ribavirin

interferon alpha 2b


Input: CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.

delay

two patients

two

delay corneal wound healing

colchicine

colchicine

corneal wound


Input: Gemcitabine-associated hemolytic-uremic syndrome.

associated

hemolytic-uremic syndrome

Gemcitabine

Gemcitabine


Input: Case study: adverse response to clonidine.

to

adverse response

clonidine

clonidine


Input: In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation.

developed

a patient

malignant hypertension

thrombosis of the central retinal vein

on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine

undergone a renal transplantation as a result of malignant hypertension

cyclosporin

prednisone

azathioprine

5 years

cyclosporin

prednisone

azathioprine


Input: In each of the three reported patients, alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy.

evident

three reported patients

three

alteration of eyelid appearance with deepening of the lid sulcus

topical bimatoprost

bimatoprost


Input: PURPOSE: To report a case of traumatic flap dehiscence and Enterobacter keratitis 34 months after LASIK.

after

traumatic flap dehiscence and Enterobacter keratitis

34 months after LASIK

34 months after


Input: CONCLUSIONS: The risk of drug-induced rhabdomyolysis due to the potential interaction between lovastatin and azithromycin or clarithromycin should be considered before the concomitant use of these agents.

due

rhabdomyolysis

lovastatin

azithromycin

clarithromycin

lovastatin

azithromycin

clarithromycin

lovastatin

azithromycin

clarithromycin


Input: Ten years of behavioral data are presented to support the hypothesis that phenobarbital was exacerbating maladaptive behaviors.

exacerbating

maladaptive behaviors

phenobarbital

phenobarbital


Input: Terbinafine-induced cholestatic liver disease.

induced

cholestatic liver disease.

Terbinafine

Terbinafine


Input: The proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL-induced apoptosis in several human cancers.

induced

apoptosis in several human cancers

proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL

Bortezomib


Input: METHODS: A retrospective report of the first case of gemcitabine-related HUS, in a patient with metastatic pancreatic adenocarcinoma, treated with a variety of standard therapies in addition to rituximab is presented.

related

a patient with metastatic pancreatic adenocarcinoma

HUS

gemcitabine

gemcitabine

metastatic pancreatic adenocarcinoma,


Input: Their parkinsonism improved on discontinuation of metoclopramide therapy.

improved

Their parkinsonism

discontinuation of metoclopramide therapy

metoclopramide

parkinsonism


Input: Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.

induced

Lichen planus

hepatitis B vaccination

hepatitis B vaccination


Input: A total of 40 healthy volunteers were planned to start with 600 mg rifampicin once daily from days 1-5.

start

40 healthy volunteers

600 mg rifampicin once daily from days 1-5

600 mg

rifampicin

once daily


Input: Skin necrosis secondary to low-molecular weight heparin in a patient with antiphospholipid antibody syndrome.

secondary to

a patient with antiphospholipid antibody syndrome

Skin necrosis

low-molecular weight heparin

antiphospholipid antibody syndrome

low-molecular weight heparin


Input: Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction.

induced

early chronic cardiomyopathy

anthracycline

with ATRA

anthracycline

ATRA

anthracycline

ATRA


Input: Fixed drug eruption in hands caused by omeprazole.

caused

Fixed drug eruption in hands

omeprazole

omeprazole


Input: FK506, which began to be administered 12 days earlier, rose to a level of 44 ng/mL (normal range, 10-20 ng/mL) 1 day before neurologic abnormalities began.

before

neurologic abnormalities began

FK506, which began to be administered 12 days earlier, rose to a level of 44 ng/mL (normal range, 10-20 ng/mL)

12 days earlier


Input: Sweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation.

causes

Sweet's syndrome is an acute febrile neutrophilic dermatosis

increased neutrophil proliferation and differentiation

filgrastim

filgrastim


Input: Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated.

induced

cardiotoxicity

diphenhydramine

diphenhydramine


Input: We describe a patient who experienced chronic nausea and an episode of confusion while treated with a small, stable dose of oral morphine in the setting of mild renal insufficiency.

experienced

a patient

mild renal insufficiency

chronic nausea and an episode of confusion

a small, stable dose of oral morphine

small, stable dose

oral

morphine


Input: Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia.

complicating

children with leukemia

children

Bulbar and pseudobulbar palsy

high-dose cytosine arabinoside

cytosine arabinoside

high-dose

leukemia


Input: The development of erythroid leukemia plus carcinoma in these two men suggests mutagenic change secondary to cyclophosphamide therapy.

suggests

two men

two

men

development of erythroid leukemia plus carcinoma

mutagenic change

cyclophosphamide therapy

cyclophosphamide


Input: Administration of thiazide diuretics also has been the cause of hyponatremia.

cause

hyponatremia

thiazide diuretics

thiazide diuretics


Input: Serotonin syndrome is a potentially lethal adverse drug reaction that may occur in patients taking proserotoninergic medications.

occur

patients

Serotonin syndrome

proserotoninergic medications

proserotoninergic

Serotonin syndrome


Input: However, there remain questions concerning whether these drugs, especially methimazole (MMI), may be associated with aplasia cutis congenita (ACC) and how best to avoid impairment of fetal thyroid function during their use.

associated

aplasia cutis congenita

methimazole

methimazole (MMI)


Input: An 18-year-old man with attention-deficit-hyperactivity disorder (ADHD) was prescribed varenicline for smoking cessation.

prescribed

An 18-year-old man with attention-deficit-hyperactivity disorder (ADHD)

man

attention-deficit-hyperactivity disorder (ADHD)

varenicline

varenicline

smoking cessation


Input: The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.

develop

patients

unexplained abdominal pain or collapse

vasopressin

vasopressin


Input: The present observation suggests, that a batch of different testing doses, including lower testing doses may help to differentiate between an allergic type of contact dermatitis and an irritant type of reaction after treatment with calcipotriol.

after treatment

an allergic type of contact dermatitis

an irritant type of reaction

calcipotriol

calcipotriol


Input: Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.

after

two cases

two

Acute erythroid leukemia

cyclophosphamide therapy

cyclophosphamide

multiple myeloma


Input: A combination of behavioural and cognitive adverse effects is illustrated in this case report of a recurrent triazolam-induced eating disorder.

induced

eating disorder

triazolam

triazolam


Input: 5-fluorouracil (5-FU)-associated peripheral neuropathy is an uncommon event.

associated

peripheral neuropathy


Input: Insulin-induced lipoatrophy in type I diabetes.

induced

lipoatrophy

Insulin

type I diabetes

Insulin


Input: This article describes a patient with suspected ciprofloxacin-induced interstitial nephritis.

induced

a patient

interstitial nephritis

ciprofloxacin

ciprofloxacin


Input: We report 3 cases of HIV-1 infected patients who experienced symptomatic angiolipomas shortly after starting antiretroviral therapy including the protease inhibitor indinavir.

experienced

3 cases of HIV-1 infected patients

symptomatic angiolipomas

antiretroviral therapy including the protease inhibitor indinavir

indinavir


Input: Depressive symptoms disappeared after interferon therapy was stopped.

after

Depressive symptoms

interferon therapy

interferon


Input: Coumarin is reported to elevate liver function tests (LFT) values.

reported

elevate liver function tests (LFT) values

Coumarin

Coumarin


Input: Decreased plasma cortisol level during alprazolam treatment of panic disorder: a case report.

during

Decreased plasma cortisol level

alprazolam

alprazolam

panic disorder


Input: Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).

induced

diffuse interstitial pneumonitis

carmustine (BCNU)

carmustine


Input: Fever, pulmonary infiltrates, and pleural effusion following acyclovir therapy for herpes zoster ophthalmicus.

following

Fever, pulmonary infiltrates, and pleural effusion

acyclovir therapy for herpes zoster ophthalmicus

herpes zoster ophthalmicus

acyclovir


Input: We propose a mechanism of vancomycin-induced mast cell degranulation and subsequent release of eosinophil chemotactic factor as a cause of CSFE.

induced

mast cell degranulation and subsequent release of eosinophil chemotactic factor as a cause of CSFE

vancomycin

vancomycin


Input: Within 3 weeks of beginning continuous daily isoniazid and rifampin therapy for pulmonary tuberculosis, a patient developed acute renal failure.

developed

a patient

acute renal failure

Within 3 weeks of beginning continuous daily isoniazid and rifampin

pulmonary tuberculosis

Within 3 weeks of beginning

daily

isoniazid

rifampin

isoniazid

rifampin


Input: We report four cases of severe corneal ulceration in methamphetamine abusers.

in

four cases

four

corneal ulceration

methamphetamine

methamphetamine


Input: Diagnosis: practolol induced sclerosing peritonitis.

induced

sclerosing peritonitis

practolol

practolol


Input: We report the first biopsy confirmed occurrence of acute interstitial nephritis in a patient receiving treatment with Sunitinib for metastatic renal cell cancer.

occurrence

patient

acute interstitial nephritis

Sunitinib

metastatic renal cell cancer

Sunitinib


Input: Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.

presentation

Multiple pulmonary nodules

fludarabine

fludarabine


Input: Clozapine-induced tardive dyskinesia in schizophrenic patients taking clozapine as a first-line antipsychotic drug.

induced

schizophrenic patients

tardive dyskinesia

Clozapine

Clozapine

schizophrenic


Input: Recently, her serum theophylline levels had increased to the toxic range (133.2 micromol/L [24 microg/mL]) shortly after the addition of zafirlukast (Accolate, Zeneca Pharmaceuticals, Wilmington, Del) to her regimen.

after

her

her

theophylline levels had increased to the toxic range

zafirlukast

zafirlukast


Input: Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy.

associated

an infant

infant

Withdrawal emergent syndrome

maternal haloperidol therapy

haloperidol

maternal


Input: Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria.

affected

adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria

Diphenylhydantoin

Diphenylhydantoin


Input: Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer.

induced

interstitial pneumonitis

bicalutamide and leuprorelin acetate

bicalutamide

leuprorelin acetate

prostate cancer

bicalutamide

leuprorelin acetate


Input: Gold-induced pneumonitis.

induced

pneumonitis

Gold

Gold


Input: OBJECTIVE: To report a case of significant hepatic and renal failure with the use of argatroban in a patient with heparin-induced thrombocytopenia (HIT) requiring continuous veno-veno hemodialysis (CVVHD).

use

a patient with heparin-induced thrombocytopenia (HIT) requiring continuous veno-veno hemodialysis (CVVHD)

heparin-induced thrombocytopenia (HIT)

significant hepatic and renal failure

argatroban

argatroban


Input: Visceral leishmaniasis and macrophagic activation syndrome in a patient with rheumatoid arthritis under treatment with adalimumab.

under

a patient with rheumatoid arthritis

Visceral leishmaniasis and macrophagic activation syndrome

adalimumab

rheumatoid arthritis

adalimumab


Input: He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later.

resolved

He

He

possible serotonin syndrome

clozapine

clozapine


Input: Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura.

following

Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria

Rh(0)(D) immune globulin intravenous

Rh(0)(D) immune globulin

intravenous

immune thrombocytopenic purpura


Input: Two patients had ampicillin-associated seizures.

associated

seizures

ampicillin

ampicillin


Input: A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.

developed

A patient

restless legs symptoms

interferon-alpha (IFN alpha) therapy

interferon-alpha

chronic hepatitis C.


Input: While many can benefit from coadministration of serotonergic antidepressants and opioids, it appears that some individuals are at increased risk for SS.

risk

some individuals

SS

coadministration of serotonergic antidepressants and opioids

serotonergic antidepressants

opioids

opioids

serotonergic antidepressants


Input: Stomatitis, diarrhea, dermatitis, and myelosuppression are the main toxicities of 5-FU.

toxicities

diarrhea

dermatitis

myelosuppression

Stomatitis


Input: After treatment with cimetidine, there was a rapid deterioration with decreased oxygen saturation and arterial PO2 values.

was

a rapid deterioration with decreased oxygen saturation and arterial PO2 values

cimetidine

cimetidine


Input: We describe a case of advanced ovarian carcinoma who developed difficulty walking because of marked pain in the lower extremities and loss of proprioception 25 days after treatment with weekly taxol (80 mg/m(2)x3).

developed

a case of advanced ovarian carcinoma

difficulty walking because of marked pain in the lower extremities and loss of proprioception

25 days after treatment with weekly taxol (80 mg/m(2)x3)

25 days

taxol

weekly

80 mg/m(2)x3

advanced ovarian carcinoma


Input: Agranulocytosis and granulocytopenia associated with quetiapine.

associated

Agranulocytosis and granulocytopenia

quetiapine

quetiapine


Input: The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy.

reported

multiple comedones and ruptured epidermoid cysts

imiquimod therapy

imiquimod


Input: We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimodipine.

related

patients

ileus

calcium antagonist

nimodipine

nimodipine


Input: Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection.

during

Hyperpigmentation

interferon-alpha therapy

interferon-alpha

chronic hepatitis C virus infection


Input: Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.

induced

chromosome damage

Chlorambucil

Chlorambucil


Input: Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition.

is

hypersensitivity syndrome

Carbamazepine

Carbamazepine


Input: Case report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider.

associated

hypersensitivity syndrome

dapsone

dapsone


Input: Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate.

exposed

a healthy normal volunteer

Acute asymptomatic hepatitis

2 oral doses of amodiaquine and artesunate

oral

amodiaquine

artesunate

artesunate

amodiaquine


Input: The authors report a case of focal myocardial necrosis, presenting clinically as an acute myocardial infarction during the administration of the antineoplastic drug, amsacrine, in a patient without coronary artery disease.

during

a patient without coronary artery disease

focal myocardial necrosis, presenting clinically as an acute myocardial infarction

amsacrine

amsacrine


Input: Baclofen and oxazepam were prescribed secondary to right-sided hemiparesis contractures.

prescribed

oxazepam

Baclofen

right-sided hemiparesis contractures

Baclofen

oxazepam

oxazepam

Baclofen


Input: DISCUSSION: A review of the cases of SS with implication of mirtazapine as the cause was performed.

implication of

SS

mirtazapine

mirtazapine


Input: A small number of oxaliplatin-related hemolytic and/or thrombocytopenic reactions have been reported.

related

hemolytic and/or thrombocytopenic reactions

oxaliplatin

oxaliplatin


Input: CASE SUMMARY: A 39-year-old white Jewish schizophrenic man treated with olanzapine developed an elevated serum CK concentration with a peak concentration of 4000 IU/L (normal < 230).

developed

A 39-year-old white Jewish schizophrenic man

white Jewish

man

an elevated serum CK concentration

olanzapine

schizophrenic

olanzapine


Input: Severe water intoxication secondary to the concomitant intake of non-steroidal anti-inflammatory drugs and desmopressin: a case report and review of the literature.

secondary to

Severe water intoxication

the concomitant intake of non-steroidal anti-inflammatory drugs and desmopressin

non-steroidal anti-inflammatory drugs

desmopressin

non-steroidal anti-inflammatory drugs

desmopressin


Input: An apparent link is described between the use of MMF with prednisone to treat pemphigus vulgaris and the development of red blood cell anemia.

development

red blood cell anemia

MMF with prednisone to treat pemphigus vulgaris

pemphigus vulgaris

MMF

prednisone

MMF

prednisone


Input: Other potential causes of renal failure were not present in our patient and his renal function gradually recovered with the cessation of suramin treatment.

recovered

our patient

his renal function gradually recovered

cessation of suramin treatment

suramin

cessation


Input: Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.

produce

reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia

Massive CBZ OD

OD

CBZ


Input: This is the first report of a fluoxetine-related death in a child with a confirmed genetic polymorphism of the CYP2D6 gene that results in impaired drug metabolism.

related

a child with a confirmed genetic polymorphism of the CYP2D6 gene that results in impaired drug metabolism

child

genetic polymorphism of the CYP2D6 gene that results in impaired drug metabolism

death

fluoxetine

fluoxetine


Input: We report a case of reversible DKA and new-onset DM that developed in a demented patient who was treated with quetiapine for 14 days.

developed

demented patient

reversible DKA and new-onset DM

quetiapine for 14 days

demented

quetiapine

14 days


Input: We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate.

induced

3 cases

cardiac toxicity

diphenhydramine

diphenhydramine


Input: The patient's arthritis flared after the second infusion of infliximab, which was discontinued.

after

patient's

arthritis flared

second infusion of infliximab

infliximab

infusion

second


Input: CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy.

associated

Marked visual field constriction

vigabatrin therapy

vigabatrin


Input: Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine.

after

serotonin syndrome associated with clomipramine

withdrawal of clozapine

clozapine

clomipramine


Input: A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.

developed

A 14-year-old female

female

systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA)

administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy

carbamazepine

benign Rolandic epilepsy


Input: There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.

a clear relationship

recurrence of the transient myopia

Accutane

Accutane


Input: Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C.

during

Graves' hyperthyroidism following transient thyrotoxicosis

interferon therapy

interferon therapy

chronic hepatitis type C.


Input: Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment.

exposed

5 of 39 (12.8%)

5 of 39 (12.8%)

Masculinization of a female fetus

clitoral hypertrophy

norethisterone

norethisterone


Input: She continued taking verapamil for 6 months, then, on her own, stopped all medications including the sustained-release verapamil, and her asthma symptoms disappeared.

disappeared.

She

She

continued taking verapamil for 6 months, then, on her own, stopped all medications including the sustained-release verapamil

asthma

verapamil

for 6 months


Input: Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.

reactions

one

manifested general erythema, dyspnea, and hypotension

cisplatin

involving intrahepatic artery infusion

cisplatin

ovarian cancer

intrahepatic artery infusion


Input: CONCLUSION: There are only a few confirmed cases of gemcitabine-associated HUS despite the widespread use of the drug.

associated

HUS

gemcitabine

gemcitabine


Input: In these patients, long-acting octreotide may trigger serious hypoglycemia.

trigger

these patients

serious hypoglycemia

long-acting octreotide

octreotide


Input: Usefulness of antiplatelet drugs in the management of heparin-associated thrombocytopenia and thrombosis.

associated

thrombocytopenia and thrombosis

heparin

heparin


Input: An intertrigo-like eruption from pegylated liposomal doxorubicin.

from

intertrigo-like eruption

pegylated liposomal doxorubicin

doxorubicin


Input: We report a case of NEH masquerading as cutaneous vasculitis in a woman receiving cyclophosphamide for lupus nephritis.

in

a woman

for lupus nephritis

woman

NEH masquerading as cutaneous vasculitis

cyclophosphamide

cyclophosphamide

lupus nephritis.


Input: The diagnosis of hypothermia was delayed until it was apparent for several days but resolved with the discontinuation of risperidone and continuation of clozapine.

resolved

discontinuation of risperidone and continuation of clozapine

clozapine

risperidone

hypothermia


Input: Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol.

treated

patient

Unaccountable severe hypercalcemia

dihydrotachysterol

hypoparathyroidism

dihydrotachysterol


Input: Anaphylaxis to calcitonin.

to

Anaphylaxis

calcitonin

calcitonin


Input: However, he developed acute renal failure, hyperkalemia, and hyperuricemia 30 d after receiving the sorafenib treatment.

developed

he

he

acute renal failure, hyperkalemia, and hyperuricemia

sorafenib

sorafenib

30 d


Input: Mycobacterium marinum infection complicating Crohn's disease, treated with infliximab.

treated

infliximab

Mycobacterium marinum infection complicating Crohn's disease

infliximab


Input: Current immunosuppressive therapies are effective but can be associated with significant adverse reactions.

associated

significant adverse reactions.

Current immunosuppressive therapies

immunosuppressive


Input: This report describes the first association (exclusive of drug overdose) of symptomatic torsades de pointes occurring with the use of terfenadine in a patient who was taking the recommended prescribed dose of this drug in addition to cefaclor, ketoconazole, and medroxyprogesterone.

occurring

a patient

symptomatic torsades de pointes

terfenadine

taking the recommended prescribed dose of this drug in addition to cefaclor, ketoconazole, and medroxyprogesterone

cefaclor

ketoconazole

medroxyprogesterone

terfenadine

terfenadine

cefaclor

ketoconazole

medroxyprogesterone


Input: Tamoxifen is suggested to be carcinogenic both through direct genotoxic and epigenetic mechanisms.

suggested

carcinogenic both through direct genotoxic and epigenetic mechanisms

Tamoxifen

Tamoxifen


Input: DISCUSSION: Colchicine, the most important drug in treatment of FMF, can cause myopathy in patients with impaired renal and hepatic function.

cause

patients with impaired renal and hepatic function

impaired renal and hepatic function

myopathy

Colchicine

Colchicine

FMF


Input: In the presented case fluvoxamine-induced akathisia in an OCD patient was partially resistant to the anticholinergic agent biperiden, and was successfully treated with the 5-HT2A/5-HT2C antagonist mianserin.

treated

fluvoxamine-induced akathisia in an OCD patient

5-HT2A/5-HT2C antagonist mianserin

akathisia

OCD

mianserin


Input: SUBSEQUENT COURSE: The nephrosis resolved almost completely once the interferon was stopped and after immunosuppressive treatment.

resolved

interferon was stopped and after immunosuppressive treatment

interferon

immunosuppressive

nephrosis


Input: In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon.

increased

In two patients

two

intensity of the dyskinesias in the afternoon

apomorphine

apomorphine


Input: Transient asymptomatic bradycardia in patients on infusional 5-fluorouracil.

on

patients

Transient asymptomatic bradycardia

infusional 5-fluorouracil.

infusional


Input: In 2006, he was diagnosed with deep vein thrombosis and pulmonary embolism and was started on warfarin.

started

he

he

warfarin

deep vein thrombosis and pulmonary embolism

warfarin


Input: Scleritis complicating zoledronic acid infusion.

complicating

Scleritis

zoledronic acid infusion

zoledronic acid

infusion


Input: A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.

developed

A 22-year-old black man

black

man

fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption

minocycline therapy

acne

minocycline

3 weeks


Input: Ticlopidine-induced aplastic anemia: two new case reports, review, and meta-analysis of 55 additional cases.

induced

aplastic anemia

Ticlopidine

Ticlopidine


Input: This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.

caused

acute lung injury and diffuse alveolar damage

mefloquine

mefloquine


Input: A case of Erythema Multiforme Bullosum in patient of lepromatous leprosy with pulmonary tuberculosis due to Rifampicin is described.

due to

patient of lepromatous leprosy with pulmonary tuberculosis

Erythema Multiforme Bullosum

Rifampicin

pulmonary tuberculosis

lepromatous leprosy

Rifampicin


Input: Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.

after

Life-threatening alterations in heart rate

adenosine

adenosine


Input: We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.

treated with

a 23-year-old man with Crohn's disease

man

pancytopenia

5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day

Crohn's disease

5-aminosalicylic acid

Pentasa

3.0 g/day


Input: The ampicillin rash occurring in cases of infectious mononucleosis is well documented.

occurring

The ampicillin rash

ampicillin

ampicillin

infectious mononucleosis


Input: The major side effect of infliximab is infection.

of

infection

infliximab

infliximab


Input: An asymptomatic HIV-infected woman experienced right-sided renal colicky pain during treatment with indinavir.

experienced

An asymptomatic HIV-infected woman

woman

right-sided renal colicky pain

indinavir

indinavir

HIV


Input: The case resembles two previously reported cases of optic neuropathy which occurred in patients with Wilson's disease who were receiving penicillamine.

occurred

patients with Wilson's disease

optic neuropathy

penicillamine

penicillamine

Wilson's disease


Input: Cutaneous ulceration: an unusual complication of intravenous pentamidine therapy.

complication

Cutaneous ulceration

intravenous pentamidine

pentamidine

intravenous


Input: Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy.

appear

Pulmonary hemorrhage

MMC

MMC


Input: Immunosuppression elicited by the extensive administration of prednisolone was suspected for the initiation of the generalized mite infestation.

generalized

mite infestation

extensive administration of prednisolone

prednisolone


Input: The episode appeared to have been precipitated by toxicity due to ingestion of a large amount of phenytoin.

due

The episode appeared to have been precipitated by toxicity

a large amount of phenytoin.

ingestion

phenytoin

large amount


Input: Cardiopulmonary arrest following intravenous phenytoin loading.

following

Cardiopulmonary arrest

intravenous phenytoin loading

intravenous

phenytoin


Input: Although taxol has shown significant activity in advanced ovarian cancer, peripheral neuropathy is likely to become the major dose-limiting toxicity.

toxicity.

peripheral neuropathy

taxol

taxol


Input: Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis.

associated

a child with psoriatic arthritis

child

Syringotropic hypersensitivity reaction

infliximab and leflunomide combination therapy

infliximab

leflunomide

psoriatic arthritis

leflunomide

infliximab


Input: Corticosteroid therapy was continued for 8 months since there was still improvement of pulmonary function studies.

improvement

Corticosteroid

for 8 months

pulmonary function

Corticosteroid

for 8 months


Input: OBJECTIVE: To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.

induced

an elderly patient with dementia and comorbidities

elderly

rhabdomyolysis

sertraline

comorbidities

dementia

sertraline


Input: Beyond the predictable pharmacokinetic drug-drug interaction requiring a significant warfarin dose reduction, the iodine-rich amiodarone affects the thyroid gland, causing overt hypothyroidism or thyrotoxicosis in 14%-18% of cases.

causing

overt hypothyroidism or thyrotoxicosis

iodine-rich amiodarone

iodine-rich amiodarone


Input: Toxic epidermal necrolysis associated with interleukin-2.

associated

Toxic epidermal necrolysis


Input: The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure.

cause

pulmonary toxicity

life-threatening respiratory failure

gold salts

gold


Input: With its characteristics, tizanidine has the potential to compromise hemodynamic stability during concomitant angiotensin-converting enzyme inhibitor use.

compromise

compromise hemodynamic stability

tizanidine

during concomitant angiotensin-converting enzyme inhibitor use

tizanidine

angiotensin-converting enzyme inhibitor

tizanidine

angiotensin-converting enzyme inhibitor


Input: Premature closure of the ductus arteriosus: variable response among monozygotic twins after in utero exposure to indomethacin.

after

monozygotic twins

Premature closure of the ductus arteriosus

in utero exposure to indomethacin

indomethacin

in utero exposure


Input: Possible mechanisms by which clonidine decreases spasticity are described, probable mechanisms of induced bradycardia are reviewed, and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented.

induced

bradycardia

clonidine

clonidine

spinal cord injured


Input: This is the first report of a possible association between an acute cardiovascular event and venlafaxine.

association

an acute cardiovascular event

venlafaxine

venlafaxine


Input: Since early symptoms of the toxic effects of theophylline can mimic peptic ulcer disease, cimetidine might be prescribed for the gastrointestinal symptoms with subsequent worsening of theophylline poisoning.

prescribed

cimetidine

gastrointestinal symptoms

cimetidine


Input: Acute renal failure in a patient receiving treatment with suramin.

in

a patient

Acute renal failure

suramin

suramin


Input: A further case of anaphylactoid reaction to methylprednisolone is reported.

to

anaphylactoid reaction

methylprednisolone

methylprednisolone


Input: Pulmonary hemorrhage as a clinical manifestation of hemolytic-uremic syndrome associated with mitomycin C therapy.

associated

Pulmonary hemorrhage

hemolytic-uremic syndrome

mitomycin C therapy

mitomycin C


Input: EEG abnormalities were observed in two of the nine children during chlorambucil therapy.

observed

two of the nine children

two of the nine

children

EEG abnormalities

chlorambucil

chlorambucil


Input: Discontinuation of the itraconazole caused resolution of the drug eruption.

caused

drug eruption

itraconazole

itraconazole


Input: The addition of intrathecal methotrexate to treatment protocols has increased survival rates in children with acute lymphoblastic leukemia but is also associated with varying degrees of neurotoxicity.

associated

in children with acute lymphoblastic leukemia

children

varying degrees of neurotoxicity

The addition of intrathecal methotrexate to treatment protocols

methotrexate

acute lymphoblastic leukemia


Input: We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.

results in

this metabolic defect

metabolic defect

unusual presentation of life-threatening toxicity

topical 5-FU (a drug demonstrating a narrow therapeutic index)

topical


Input: Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine.

developed

Six patients with rheumatoid arthritis

Six

syndrome resembling lupus erythematosus

penicillamine

penicillamine

rheumatoid arthritis


Input: This case highlights the need to monitor liver enzymes in patients treated with 6-TG and identifies the need for additional research focused on the mechanism of thiopurine-induced hepatic injury.

induced

patients treated with 6-TG

hepatic injury

thiopurine

thiopurine


Input: During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.

developed

four out of the seven patients

four out of the seven

moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia

During clarithromycin coadministration

carbamazepine

During

clarithromycin

carbamazepine

clarithromycin

carbamazepine


Input: 5-Fluorouracil (5-FU) is an analogue of pyrimidine nucleosides that is widely used in the treatment of head and neck, breast, ovarian, and colon cancer.

used

5-Fluorouracil (5-FU) is an analogue of pyrimidine nucleosides

5-Fluorouracil (5-FU)

head and neck, breast, ovarian, and colon cancer


Input: Fulminant fatal cardiotoxicity following cyclophosphamide therapy.

following

Fulminant fatal cardiotoxicity

cyclophosphamide

cyclophosphamide


Input: The reaction in our patient appeared after tizanidine initiation and improved after both lisinopril and tizanidine were discontinued.

after

patient

reaction

tizanidine initiation

tizanidine


Input: We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation.

development

a patient with previously diagnosed CLL in minimal residual disease status

AML

lung cancer

fludarabine

autologous peripheral blood stem-cell transplantation

CLL in minimal residual disease status

fludarabine

autologous peripheral blood stem-cell

transplantation

fludarabine

autologous peripheral blood stem-cell


Input: Valproate-induced hyperammonemia as a cause of altered mental status.

induced

altered mental status

hyperammonemia

Valproate

Valproate


Input: We report 5 cases of acute reversible renal failure coinciding with the onset of treatment with captopril in patients with severe drug-resistant hypertension.

onset of treatment

patients with severe drug-resistant hypertension

acute reversible renal failure

captopril

captopril

severe drug-resistant hypertension


Input: We report a case of contact dermatitis due to sodium bisulfite in Tathion eye drops.

due

contact dermatitis

sodium bisulfite

sodium bisulfite


Input: The first patient is undergoing hemodialysis and, though responding to sunitinib, is having significant fatigue and hypertension.

having

The first patient

significant fatigue and hypertension

sunitinib

sunitinib


Input: CCBs should be considered in the treatment of 5-FU or capecitabine-induced headaches.

treatment

CCBs

CCBs

headaches


Input: Furosemide, spironolactone, allopurinol, and hydroxyurea were considered possible causes of the reaction and were discontinued.

causes

reaction

Furosemide, spironolactone, allopurinol, and hydroxyurea

Furosemide

spironolactone

allopurinol

hydroxyurea


Input: PATIENTS: One patient with mucositis secondary to chemotherapy.

secondary

One patient

One

mucositis

chemotherapy

chemotherapy


Input: A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog.

had

A patient with monocular open-angle glaucoma

trichiasis

a prostaglandin analog

monocular open-angle glaucoma

prostaglandin analog


Input: A 53-year-old African American male with HIV was prescribed warfarin 5 mg/day for 12 months after diagnosis of idiopathic deep vein thrombosis and bilateral pulmonary emboli (target INR 2.5 [range 2.0-3.0]).

prescribed

A 53-year-old African American male with HIV

African American

male

HIV

warfarin 5 mg/day for 12 months

warfarin

5 mg/day

12 months

idiopathic deep vein thrombosis and bilateral pulmonary emboli


Input: After treatment with a beta-sympathomimetic drug (Partusisten) one fetus developed supraventricular tachycardia.

developed

one fetus

fetus

supraventricular tachycardia.

a beta-sympathomimetic drug (Partusisten)

Partusisten


Input: Serotonin syndrome developed in a patient taking concurrent linezolid and fluoxetine.

developed

a patient

Serotonin syndrome

concurrent linezolid and fluoxetine

linezolid

fluoxetine

linezolid

fluoxetine


Input: RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment.

treated

A male and a female patient with spasticity

male

female

sexual dysfunction

intrathecal baclofen

spasticity

baclofen

intrathecal


Input: OBJECTIVE: To describe a patient with ifosfamide-induced nonconvulsive status epilepticus.

induced

patient

nonconvulsive status epilepticus

ifosfamide

ifosfamide


Input: Upper gastrointestinal haemorrhage is a serious complication of aspirin and clopidogrel (dual) anti-platelet therapy with a high morbidity and mortality.

complication

Upper gastrointestinal haemorrhage

aspirin and clopidogrel (dual)


Input: Flecainide overdose can rapidly result in profound cardiovascular collapse, and is associated with a relatively high mortality.

result

profound cardiovascular collapse, and is associated with a relatively high mortality

Flecainide overdose

Flecainide

overdose


Input: Sulfasalazine-induced lupus erythematosus.

induced

lupus erythematosus

Sulfasalazine

Sulfasalazine


Input: Reye syndrome (RS) is believed to occur infrequently among children receiving long-term aspirin therapy.

occur

children

children

Reye syndrome (RS)

long-term aspirin

aspirin


Input: Propecia-associated bilateral cataract.

associated

bilateral cataract

Propecia

Propecia


Input: After 39 hours on argatroban, the infusion was stopped when minor bleeding was observed with a concurrent activated partial thromboplastin time (aPTT) of 100 seconds.

After

minor bleeding was observed with a concurrent activated partial thromboplastin time (aPTT) of 100 seconds

argatroban

39 hours

argatroban


Input: Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis.

to

Anaphylactoid reaction

methylprednisolone pulsed therapy

multiple sclerosis

methylprednisolone


Input: Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis.

induced

skin necrosis

Warfarin

Warfarin


Input: Surprisingly, we found that three patients appeared to develop tardive OGC while taking clozapine.

develop

three patients

three

tardive OGC

clozapine

clozapine


Input: We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).

resulting from

toxic epidermal necrolysis (TEN)

high dose of cytosine arabinoside (ARA-C)

cytosine arabinoside (ARA-C)

high dose


Input: On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.

developed

bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death

high dose of ARA-C

ARA-C

high dose

2 g/m2

the fifth day

the 22nd day

12 hours


Input: We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.

after

2 patients with cutaneous lupus erythematosus

severe dapsone reaction

with a fatal outcome in one

low dose therapy

cutaneous lupus erythematosus

low dose

dapsone


Input: A patient with ulcerative colitis developed skin pigmentation and diffuse pulmonary shadowing without respiratory symptomatology, while taking sulfasalazine.

developed

A patient with ulcerative colitis

skin pigmentation and diffuse pulmonary shadowing without respiratory symptomatology

sulfasalazine

sulfasalazine

ulcerative colitis


Input: This is a case report involving a patient who was treated with topical 5-FU cream and subsequently developed a severe case of angioedema.

developed

a patient

a severe case of angioedema

topical 5-FU cream

topical


Input: Cessation of D-Pen and the start of corticosteroid therapy were followed by recovery from bicytopenia.

followed

recovery from bicytopenia

Cessation of D-Pen and the start of corticosteroid therapy

D-Pen

corticosteroid

bicytopenia


Input: Prevention of infection by immunization, together with early recognition and prompt antiviral treatment are critical.

Prevention

immunization, together with early recognition and prompt antiviral treatment

infection


Input: A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment.

after

A case

normotensive scleroderma renal crisis

high-dose methylprednisolone treatment

high-dose

methylprednisolone


Input: OBJECTIVES: A delayed stroke-like leukoencephalopathy has been observed in patients receiving methotrexate (MTX) for childhood leukemia.

has been observed

patients

childhood leukemia

childhood

delayed stroke-like leukoencephalopathy

methotrexate (MTX)

methotrexate

childhood leukemia


Input: Duloxetine-induced hyponatremia in an elderly patient treated with thiazide diuretics.

induced

an elderly patient treated with thiazide diuretics

elderly

hyponatremia

Duloxetine

Duloxetine

thiazide diuretics

thiazide diuretics

Duloxetine


Input: The following is a case report analysis intended to draw attention to the need for better care coordination by describing the observed relationship of olanzapine to metabolic changes manifested as uncontrolled diabetes mellitus and weight gain.

relationship

metabolic changes manifested as uncontrolled diabetes mellitus and weight gain

olanzapine

olanzapine


Input: Arsenic trioxide has recently been introduced as a promising new agent to treat refractory acute promyelocytic leukemia (APL).

treat

Arsenic trioxide

Arsenic trioxide

refractory acute promyelocytic leukemia


Input: Although the t-AML developed following oral etoposide therapy, the child had previously received high-dose, multiagent chemotherapy, and rearrangement of the MLL gene was not demonstrated.

developed

the child

child

the t-AML

oral etoposide therapy

high-dose, multiagent chemotherapy

etoposide

chemotherapy

oral

high-dose

chemotherapy

etoposide


Input: Heat stroke in schizophrenia during clozapine treatment: rapid recognition and management.

during

Heat stroke

clozapine

schizophrenia

clozapine


Input: The same symptoms recurred few days after taking nitrendipine.

taking

same symptoms

nitrendipine

few days after

few days after

nitrendipine


Input: The authors report two cases of acute dystonic reactions (ADRs) as a side effect of lamivudine.

effect

two cases

two

acute dystonic reactions (ADRs)

lamivudine

lamivudine


Input: Isoniazid-induced anaphylaxis.

induced

anaphylaxis

Isoniazid

Isoniazid


Input: Histopathology of the thyroid in amiodarone-induced hypothyroidism.

induced

hypothyroidism

amiodarone

amiodarone


Input: Deepening of lid sulcus from topical bimatoprost therapy.

from

Deepening of lid sulcus

bimatoprost

bimatoprost


Input: Gastro-oesophageal reflux associated with nifedipine.

associated

Gastro-oesophageal reflux

nifedipine

nifedipine


Input: CASE SUMMARY: A 68-year-old woman developed a dry, irritating cough within one month of starting quinapril therapy for the treatment of essential hypertension.

starting

A 68-year-old woman

woman

a dry, irritating cough

quinapril therapy

within one month

quinapril

essential hypertension


Input: Sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.

induced

an elderly patient with dementia and comorbidities

elderly

dementia

comorbidities

rhabdomyolysis

Sertraline

Sertraline


Input: After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.

disappeared

After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer

a few hours later

psychotic reaction

a few hours

methylprednisolone

reduced from 40 mg to 20 mg i.v. q6h

spacer


Input: Sirolimus works differently from the immunosuppressants currently available, and except for increased lipid levels, the adverse reaction profile of sirolimus does not appear to overlap to any great extent with that associated with cyclosporine or tacrolimus.

for

increased lipid levels

Sirolimus works differently from the immunosuppressants currently available

Sirolimus

immunosuppressants

sirolimus

cyclosporine

tacrolimus


Input: Patient was on warfarin for a prior deep venous thrombosis.

for

warfarin

a prior deep venous thrombosis

warfarin


Input: Quetiapine-induced myoclonus.

induced

myoclonus

Quetiapine

Quetiapine


Input: Dyspnea possibly associated with controlled-release morphine sulfate tablets.

associated

Dyspnea

controlled-release morphine sulfate tablets

morphine sulfate

tablets

controlled-release


Input: The incidence of ARE suddenly exceeded 10% of the patients treated by melarsoprol during August 1992 and September 1993.

by

patients

ARE

melarsoprol

melarsoprol

August 1992 and September 1993


Input: A patient with disseminated herpes zoster developed a syndrome of inappropriate antidiuretic hormone and profound hyponatremia secondary to the administration of adenine arabinoside.

developed

A patient with disseminated herpes zoster

syndrome of inappropriate antidiuretic hormone and profound hyponatremia

adenine arabinoside

adenine arabinoside

disseminated herpes zoster


Input: One patient with systemic lupus erythematosus developed erythema multiforme after taking griseofulvin.

after

One patient with systemic lupus erythematosus

One

systemic lupus erythematosus

erythema multiforme

griseofulvin

griseofulvin


Input: We report a rare case of colonic mucosal necrosis following Kalimate (calcium polystryrene sulfonate), an analogue of Kayexalate without sorbitol in a 34-yr-old man.

following

a 34-yr-old man

man

colonic mucosal necrosis

Kalimate (calcium polystryrene sulfonate), an analogue of Kayexalate without sorbitol

Kalimate

(calcium polystryrene sulfonate)

Kayexalate


Input: Bilateral anterior uveitis associated with clomiphene citrate.

associated

Bilateral anterior uveitis

clomiphene citrate

clomiphene citrate


Input: Progressive anemia following combination therapy with interferon-alpha and interleukin-2 in a patient with metastatic renal cell carcinoma.

following

a patient with metastatic renal cell carcinoma

Progressive anemia

combination therapy with interferon-alpha and interleukin-2

metastatic renal cell carcinoma

interferon-alpha

interferon-alpha


Input: Metoclopramide-induced parkinsonism.

induced

parkinsonism

Metoclopramide

Metoclopramide


Input: A 12 year old patient with atrial flutter is presented, in whom intravenous adenosine was followed by acceleration of the heart rate to a potentially dangerous arrhythmia.

followed by

12 year old patient with atrial flutter

12 year old

acceleration of the heart rate to a potentially dangerous arrhythmia

intravenous adenosine

adenosine

intravenous

atrial flutter


Input: Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity.

receiving

patients

erlotinib pulmonary toxicity.

gefitinib

gefitinib


Input: Eleven days after increase of the trimipramine dosage to 100 mg/d, she was hospitalized because of seizures suggesting a secondary generalized grand-mal episode.

hospitalized

she

she

seizures suggesting a secondary generalized grand-mal episode

Eleven days after increase of the trimipramine dosage to 100 mg/d

Eleven days

100 mg/d

trimipramine


Input: AIM: To report a patient with diabetic rubeosis who suffered from acute retinal ischemic change and stroke after intravitreal injection of bevacizumab.

suffered

patient with diabetic rubeosis

acute retinal ischemic change and stroke

intravitreal injection of bevacizumab

diabetic rubeosis

bevacizumab

intravitreal injection


Input: Stevens-Johnson syndrome caused by the antiretroviral drug nevirapine.

caused by

Stevens-Johnson syndrome

antiretroviral drug nevirapine

nevirapine


Input: From these data, acute generalized dystonia with brainstem and thalamic lesions may occur in WD patients after an initial d-penicillamine therapy.

after

WD patients

acute generalized dystonia with brainstem and thalamic lesions

an initial d-penicillamine therapy

WD

d-penicillamine


Input: Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare.

induced

pediatric cases

pediatric

hepatotoxicity

TMP-SMX

TMP-SMX


Input: Drug resistant tuberculosis requires more complex and longer treatment with alternative substances.

requires

complex and longer treatment with alternative substances

Drug resistant tuberculosis

substances

complex and longer treatment


Input: Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report.

in

a patient

Intracranial haemorrhage from a meningioma

aspirin

aspirin


Input: The objective of this report is to describe a case of fixed drug eruption that occurred during omeprazole treatment.

occurred

fixed drug eruption

during omeprazole treatment

omeprazole


Input: Case 2: A 43-year-old male alcoholic remained completely abstinent with cyanamide treatment for 5 years and complained of general fatigue.

complained

A 43-year-old male alcoholic

male

general fatigue

completely abstinent with cyanamide treatment for 5 years

alcoholic

cyanamide

5 years


Input: Delayed hypersensitivity to flurbiprofen.

to

Delayed hypersensitivity

flurbiprofen

flurbiprofen


Input: Propafenone-induced ataxia: report of three cases.

induced

three cases

three

ataxia

Propafenone

Propafenone


Input: Delavirdine and efavirenz (but not nevirapine) also were strong inhibitors of CYP3A, consistent with clinical hazards of initial cotreatment with either of these drugs and substrates of CYP3A.

consistent with

clinical hazards

Delavirdine and efavirenz (but not nevirapine)

Delavirdine

efavirenz


Input: This is the first report of UFT-induced scleroderma-like reaction.

induced

scleroderma-like reaction

UFT

UFT


Input: Can roxithromycin and betamethasone induce acute pancreatitis? A case report.

induce

acute pancreatitis

roxithromycin and betamethasone

roxithromycin

betamethasone

roxithromycin

betamethasone


Input: Up to four percent of patients treated with imatinib may develop hepatotoxicity, which usually resolves with discontinuation of the drug.

develop

Up to four percent of patients

Up to four percent

hepatotoxicity

imatinib

imatinib


Input: Schneiderian first-rank symptoms associated with fluvoxamine treatment: a case report.

associated

Schneiderian first-rank symptoms

fluvoxamine

fluvoxamine


Input: Peripheral and optic neuropathy was usually seen after several months of linezolid therapy (median 5 mo), lactic acidosis after several weeks (median 6 wks), and serotonin syndrome after several days (median 4 days).

after

Peripheral and optic neuropathy

lactic acidosis after several weeks (median 6 wks), and serotonin syndrome after several days (median 4 days)

several months of linezolid therapy (median 5 mo)

linezolid

several months


Input: Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases.

induced

neuromyeloencephalopathy

Muzolimine

Muzolimine


Input: We conclude peripheral neuropathy with 5-FU is rare.

with

peripheral neuropathy


Input: Additionally, danazol produces hepatocellular damage in approximately 10% of women.

produces

10% of women

women

hepatocellular damage

danazol

danazol


Input: CONCLUSIONS: We report a typical symptoms of Charles-Bonnet syndrome (CBS) in patients with severe AMD after intravitreal Avastin-injections.

after

patients with severe AMD

typical symptoms of Charles-Bonnet syndrome (CBS)

intravitreal Avastin-injections

Avastin

intravitreal

injections

AMD


Input: Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects.

side effects.

Proconvulsive tendency

imipenem/cilastatin

cilastatin

imipenem

imipenem

cilastatin


Input: A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.

developed

49-year-old man with Crohn's disease

man

worsening respiratory distress and fever.

prednisone and mesalamine (5-ASA)

Crohn's disease

mesalamine

prednisone

prednisone

mesalamine


Input: OBJECTIVE: This case report outlines a significant type of morbidity due to continued use of gabapentin during an episode of acute renal failure.

use

This case

a significant type of morbidity

gabapentin

gabapentin


Input: Acute delirium resulting from levofloxacin therapy is an exceedingly rare complication that has been thought to occur more commonly in elderly patients.

resulting

elderly patients

elderly

Acute delirium

levofloxacin

levofloxacin


Input: Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.

associated

aggravation of nonalcoholic steatohepatitis

raloxifene

raloxifene


Input: The day after methotrexate administration, the patient complained of severe back pain and urinary retention.

complained

severe back pain and urinary retention

The day after methotrexate administration

methotrexate

The day after


Input: Pulmonary toxicity secondary to procarbazine.

secondary

Pulmonary toxicity

procarbazine

procarbazine


Input: In keeping with findings in the literature, the aortic wall in this case was damaged by secondary changes following irradiation and Bleomycin treatment.

following

aortic wall in this case was damaged

irradiation and Bleomycin treatment.

Bleomycin


Input: It has been suggested that PPE caused by cytarabine does not recur with subsequent cytarabine re-challenge.

caused

PPE

cytarabine

cytarabine


Input: CONCLUSIONS: The value of multihormonal therapy in breast carcinoma is not established, and the addition of progestogens to tamoxifen may not reduce of developing endometrial lesions, including carcinoma.

may not reduce

endometrial lesions

carcinoma

addition of progestogens to tamoxifen

progestogens

tamoxifen

progestogens

tamoxifen


Input: Inappropriate antidiuretic hormone following adenine arabinoside administration.

following

Inappropriate antidiuretic hormone

adenine arabinoside

adenine arabinoside


Input: Ampicillin-associated seizures.

associated

seizures

Ampicillin

Ampicillin


Input: We describe a case of fibrosing alveolitis, diagnosed by lung biopsy, in a patient receiving amiodarone which responded to corticosteroid therapy.

receiving

a patient

fibrosing alveolitis

amiodarone which responded to corticosteroid therapy

amiodarone

corticosteroid

amiodarone

corticosteroid


Input: Furosemide-associated fever.

associated

fever

Furosemide

Furosemide


Input: Thymic enlargement in a patient with juvenile idiopathic arthritis during etanercept therapy.

during

a patient with juvenile idiopathic arthritis

juvenile

Thymic enlargement

etanercept

etanercept

idiopathic arthritis


Input: Fatal methylene blue associated serotonin toxicity.

associated

serotonin toxicity

methylene blue

methylene blue


Input: Mannitol-induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure.

induced

ARF

anuria

renal failure

Mannitol

Mannitol


Input: We report a rare case of recurrent (stuttering) priapism in a patient with protein C deficiency while maintained on Warfarin therapy.

while

a patient with protein C deficiency

recurrent (stuttering) priapism

maintained on Warfarin therapy

protein C deficiency

Warfarin


Input: Angioedema and maculopapular eruptions associated with carbamazepine administration.

associated

Angioedema and maculopapular eruptions

carbamazepine administration.

carbamazepine


Input: Mental nerve neuropathy as a result of hepatitis B vaccination.

result

Mental nerve neuropathy

hepatitis B vaccination

hepatitis B vaccination.


Input: We describe a premenopausal woman who, while having tamoxifen due to a diagnosis of in situ ductal carcinoma, developed endometriosis requiring surgery.

developed

a premenopausal woman

woman

premenopausal

endometriosis

tamoxifen

tamoxifen

in situ ductal carcinoma


Input: Disseminated cellulitic cryptococcosis in the setting of prednisone monotherapy for pemphigus vulgaris.

in the setting of

Disseminated cellulitic cryptococcosis

prednisone monotherapy

prednisone

pemphigus vulgaris


Input: We describe a 63 year old woman with a suppurative mediastinitis, treated with continuous PI irrigation who developed an acute oliguric renal failure.

developed

a 63 year old woman with a suppurative mediastinitis

63 year old

woman

acute oliguric renal failure

continuous PI irrigation

PI

suppurative mediastinitis

irrigation


Input: A young woman with epilepsy had tonic-clonic seizures during antineoplastic therapy with adriamycin and cisplatin.

had

A young woman with epilepsy

young

woman

tonic-clonic seizures

antineoplastic therapy with adriamycin and cisplatin.

adriamycin

cisplatin

epilepsy

adriamycin

cisplatin


Input: CONCLUSIONS: This patient's rhabdomyolysis was probably induced by sertraline therapy.

induced

This patient

rhabdomyolysis

sertraline

sertraline


Input: Nephrotic syndrome in a multiple sclerosis patient treated with interferon beta 1a.

treated

a multiple sclerosis patient

Nephrotic syndrome

interferon beta 1a

interferon beta 1a

multiple sclerosis


Input: In our patient, DIAN possibly was related to cefuroxime, but the patient did not experience associated allergic symptoms.

related to

our patient

DIAN

cefuroxime

cefuroxime


Input: We describe the case of a nonatopic 17-year-old girl with bronchial asthma and aspirin intolerance who developed a dramatic anaphylactic reaction to oral prednisone.

developed

a nonatopic 17-year-old girl with bronchial asthma and aspirin intolerance

nonatopic

aspirin intolerance

girl

a dramatic anaphylactic reaction

oral prednisone

oral

prednisone

bronchial asthma


Input: CASE SUMMARY: A 10-year-old white girl with bilateral optic glioma developed a hypersensitivity reaction to carboplatin after nine courses.

developed

A 10-year-old white girl with bilateral optic glioma

girl

white

hypersensitivity reaction

carboplatin after nine courses

bilateral optic glioma

carboplatin

nine courses


Input: Liver function should be carefully monitored when rifampicin and lopinavir/ritonavir are combined in patients.

when

patients

Liver function should be carefully monitored

rifampicin and lopinavir/ritonavir are combined

rifampicin

lopinavir/ritonavir

rifampicin

lopinavir/ritonavir


Input: We report three patients, all of whom had preexisting diabetic dyslipidemia, who showed a profound reduction in plasma HDL cholesterol and apolipoprotein AI levels soon after the initiation of rosiglitazone therapy.

initiation

three patients

three

profound reduction in plasma HDL cholesterol and apolipoprotein AI levels

rosiglitazone therapy

rosiglitazone

soon after

preexisting diabetic dyslipidemia


Input: This finding suggests that fluvoxamine can precipitate Schneiderian first-rank symptoms in some susceptible patients.

precipitate

some susceptible patients

Schneiderian first-rank symptoms

fluvoxamine

fluvoxamine


Input: Warfarin-associated thoracic aortic dissection in an elderly woman.

associated

an elderly woman

elderly

woman

thoracic aortic dissection

Warfarin

Warfarin


Input: This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.

adverse effect

first report of an adverse effect of fetal renal circulation

fetal renal circulation

maternal ingestion of nimesulide

nimesulide

nimesulide

maternal ingestion


Input: Diarrhea-associated over-anticoagulation in a patient taking warfarin: therapeutic role of cholestyramine.

over-anticoagulation

patient

Diarrhea-associated over-anticoagulation

warfarin

warfarin


Input: A 72-year-old white man suddenly developed combative behavior, refused to leave his room, stopped eating, and began falling to the floor 6 weeks after being given ticlopidine.

developed

A 72-year-old white man

white

man

combative behavior, refused to leave his room, stopped eating, and began falling to the floor

6 weeks after being given ticlopidine

6 weeks

ticlopidine


Input: The case history confirms that gold treatment, even in the same patient, can give rise to a wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn.

give rise

in the same patient,

wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn

gold

gold


Input: Lithium neurotoxicity should be considered in Creutzfeldt-Jakob disease differential diagnosis, serial electroencephalograms being the most valuable.

considered

Lithium neurotoxicity

Lithium

Creutzfeldt-Jakob disease

Lithium


Input: The authors describe a case of neuroleptic malignant syndrome that occurred in a patient on amitriptyline and lithium carbonate.

occurred

a patient

neuroleptic malignant syndrome

amitriptyline and lithium carbonate

amitriptyline

lithium carbonate

amitriptyline

lithium carbonate


Input: The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.

associated

soft-tissue injury

intravenous administration of phenytoin

intravenous administration

phenytoin


Input: However, as illustrated by these and other cases reported to date, the onset of troglitazone-induced liver injury is insidious and temporally variable.

induced

liver injury is insidious and temporally variable

troglitazone

troglitazone


Input: Soon after its introduction in 1952, chlorpromazine was noted to induce symptoms resembling Parkinson's disease.

induce

symptoms resembling Parkinson's disease

chlorpromazine

chlorpromazine


Input: Erythromycin is a macrolide antibiotic that may increase the risk of lovastatin-induced rhabdomyolysis.

induced

increase the risk of lovastatin-induced rhabdomyolysis

Erythromycin

Erythromycin

lovastatin

lovastatin

Erythromycin


Input: A 23-year-old white male patient was originally admitted to receive intravenous chemotherapy for acute myelogenous leukemia.

receive

A 23-year-old white male patient

white

male

intravenous chemotherapy

chemotherapy

acute myelogenous leukemia

intravenous


Input: We present two children with acute lymphocytic leukemia who developed leukoencephalopathy following administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy.

developed

two children with acute lymphocytic leukemia

two

children

leukoencephalopathy

administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy

acute lymphocytic leukemia

intravenous

ara = C

methotrexate

ara = C

methotrexate


Input: Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.

complicating

a breast cancer patient with an impaired renal function

an impaired renal function

anuria

high dose ifosfamide chemotherapy

breast cancer

ifosfamide

chemotherapy

high dose


Input: CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.

associated

a delayed, severe maculopathy

Low dosages of quinacrine used for malaria prophylaxis

delayed

Low dosages

quinacrine

malaria prophylaxis