Input: When pilsicainide is prescribed in patients with coronary artery disease or renal dysfunction, close attention must be paid to avoid life-threatening arrhythmias due to high plasma concentrations of the drug.

due

patients with coronary artery disease or renal dysfunction,

coronary artery disease

renal dysfunction

life-threatening arrhythmias

pilsicainide

pilsicainide


Input: We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.

induced

a case

severe aplastic anemia (AA)

lenalidomide

lenalidomide


Input: We present a case report of a patient with typhoid fever who experienced a hypersensitivity reaction subsequent to the infusion of chloramphenicol sodium succinate.

subsequent to

a patient with typhoid fever

hypersensitivity reaction

the infusion of chloramphenicol sodium succinate

typhoid fever

chloramphenicol sodium succinate

infusion


Input: This confirmed the history of captopril-related asthma.

related

asthma

captopril

captopril


Input: Four cases of adverse experiences with clonidine are described.

with

Four cases

Four

adverse experiences

clonidine

clonidine


Input: OBJECTIVE: To report a case of reversible nonthrombocytopenic palpable purpura associated with metoclopramide.

associated

reversible nonthrombocytopenic palpable purpura

metoclopramide

metoclopramide


Input: Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.

developed

Three patients

Three

bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia

received respectively 190 mg, 175 mg, and 196 mg of methotrexate

190 mg

175 mg

196 mg

methotrexate


Input: Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia.

cause

SIADH and possibly hypokalemia

vinorelbine

vinorelbine


Input: We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen.

on

a 34-year-old man

man

acute liver and renal failure

carbamazepine

less than 2.5 grams a day of acetaminophen

carbamazepine

acetaminophen

complex partial seizures

less than 2.5 grams

a day

acetaminophen

carbamazepine


Input: Fever and maculopapular rashes appeared at 10 days after phenytoin initiation, and then the drug was discontinued.

appeared

Fever and maculopapular rashes

phenytoin

10 days

phenytoin


Input: We report AZA-induced drug eruption that developed in two cases of systemic scleroderma with polymyositis.

induced

two cases of systemic scleroderma with polymyositis

two

drug eruption

AZA

AZA

systemic scleroderma with polymyositis


Input: Safety aspects of a coumarin-troxerutin combination regarding liver function in a double-blind placebo-controlled study.

Safety aspects

liver function

coumarin-troxerutin combination

coumarin

troxerutin

troxerutin

coumarin


Input: Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C.

occurring

Vogt-Koyanagi-Harada disease

interferon alpha

interferon alpha

chronic hepatitis C.


Input: Glucose and insulin exert additive ocular and renal vasodilator effects on healthy humans.

exert

healthy humans

additive ocular and renal vasodilator effects

Glucose and insulin

Glucose

insulin

Glucose

insulin


Input: Two patients with osteomyelitis who developed reversible cholestatic jaundice during treatment with oxacillin derivatives are described.

developed

Two patients with osteomyelitis

Two

reversible cholestatic jaundice

oxacillin

osteomyelitis

oxacillin


Input: DATA SYNTHESIS: A 49-year-old man developed symptoms of severe psychosis concomitant with ciprofloxacin (250 mg bid) treatment.

developed

A 49-year-old man

man

psychosis

ciprofloxacin

ciprofloxacin

250 mg bid


Input: Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.

induced

obsessive-compulsive patient

akathisia

fluvoxamine

obsessive-compulsive

fluvoxamine


Input: Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.

related

keratitis

methamphetamine

methamphetamine


Input: Pulmonary oedema after hexoprenaline administration in preterm labour.

after

Pulmonary oedema

hexoprenaline

preterm labour

hexoprenaline


Input: Venlafaxine-associated seizures at therapeutic doses have not been reported in the literature.

associated

seizures

Venlafaxine

Venlafaxine


Input: Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature.

induced

patients with rheumatoid arthritis and psoriatic arthritis

pneumonitis

Methotrexate

rheumatoid arthritis

psoriatic arthritis

Methotrexate


Input: She was receiving phenytoin sodium 300 mg/day; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia.

because

leukopenia

carbamazepine 200 mg four times daily

carbamazepine

200 mg

four times daily


Input: Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.

attributable

fibrotic lesions

bleomycin or cyclophosphamide

bleomycin

cyclophosphamide


Input: We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.

developed

hemolytic-uremic syndrome

during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin

oxaliplatin

fluorouracil

leucovorin


Input: We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.

after

lung cancer patient with bronquiloalveolar carcinoma (BAC)

producing severe respiratory insufficiency, and simulating a progression of the tumor

BOOP

chemotherapy with docetaxel and gemcitabine

lung cancer

bronquiloalveolar carcinoma (BAC)

docetaxel

gemcitabine

chemotherapy

docetaxel

gemcitabine


Input: Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.

after

Relapse in the external auditory canal of acute promyelocytic leukemia

treatment with all-trans retinoic acid

all-trans retinoic acid


Input: Acute neutrophilic dermatosis induced by all-trans-retinoic acid treatment for acute promyelocytic leukemia.

induced by

Acute neutrophilic dermatosis

all-trans-retinoic acid

acute promyelocytic leukemia

all-trans-retinoic acid


Input: Fluphenazine-induced neuroleptic malignant syndrome in a schizophrenic patient.

induced

a schizophrenic patient

neuroleptic malignant syndrome

Fluphenazine

Fluphenazine

schizophrenic


Input: Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?

associated

acute interstitial nephritis

tyrosine kinase inhibitor sunitinib

sunitinib


Input: We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.

after

two women

two

women

HUS

massive pulmonary bleeding

MMC

MMC


Input: Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.

treatment

a 57-year-old woman

woman

Alternating sinus rhythm and intermittent sinoatrial (S-A) block

80 mg propranolol daily.

80 mg

propranolol

daily

angina


Input: These case reports provide evidence that 5-aminosalicylic acid may induce acute pancreatitis after long term treatment.

induce

acute pancreatitis

5-aminosalicylic acid

5-aminosalicylic acid

long term


Input: During that time, he had also been taking amphetamine-dextroamphetamine (Adderall) on work days for his ADHD.

taking

he

he

amphetamine-dextroamphetamine (Adderall)

ADHD

amphetamine-dextroamphetamine


Input: Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite.

diagnosed

her eruption as contact dermatitis

sodium bisulfite

sodium bisulfite


Input: Macular infarction after endophthalmitis treated with vitrectomy and intravitreal gentamicin.

after

Macular infarction

endophthalmitis treated with vitrectomy and intravitreal gentamicin

endophthalmitis

vitrectomy and intravitreal

gentamicin


Input: Since tamoxifen therapy can induce endometrial disorders, surveillance schemes of women taking tamoxifen have been recommended.

induce

women

women

endometrial disorders

tamoxifen therapy

tamoxifen


Input: Warfarin-associated bleeding complication saved life.

associated

bleeding complication saved life

Warfarin

Warfarin


Input: METHODS/RESULTS: This paper presents a new case of rifabutin uveitis and a review of the various published reports to date.

presents

new case

uveitis

rifabutin

rifabutin


Input: Acute abdomen due to endometriosis in a premenopausal woman taking tamoxifen.

taking

Acute abdomen due to endometriosis

tamoxifen

tamoxifen


Input: DISCUSSION: Methotrexate-induced papular eruption is rarely reported shortly after beginning methotrexate therapy in patients with acute exacerbation of collagen vascular diseases.

induced

patients with acute exacerbation of collagen vascular diseases

acute exacerbation of collagen vascular diseases

papular eruption

Methotrexate

Methotrexate

shortly after


Input: We describe 3 patients on concomitant amiodarone and warfarin who developed amiodarone-induced thyrotoxicosis heralded by a significant decrease in warfarin requirements.

developed

3 patients

amiodarone-induced thyrotoxicosis

concomitant amiodarone and warfarin

amiodarone

warfarin

amiodarone

warfarin


Input: The aim of this post-hoc analysis of data from a Phase III clinical trial (VISTA; NCT00298831) was to investigate the impact of antibiotics on recovery from rocuronium-induced NMB after administration of sugammadex for reversal, and compared the neuromuscular recovery in patients who received antibiotics preoperatively with those who did not.

induced

NMB

rocuronium

rocuronium


Input: All patients had taken phenytoin for variable time periods (range 16-80 days; mean: 40) and were on the medication when the skin lesions first appeared.

appeared.

All patients

skin lesions

phenytoin for variable time periods (range 16-80 days; mean: 40)

phenytoin

16-80 days;


Input: One should therefore be aware of possible extrapyramidal side effects with olanzapine that are reduced compared to classical neuroleptic drugs but not completely eliminated.

with

extrapyramidal side effects

olanzapine

olanzapine


Input: A patient who had been treated with large doses of thyroid hormone for several years developed features of secondary hypothyroidism after thyroid hormone withdrawal.

developed

A patient

secondary hypothyroidism

thyroid hormone withdrawal

thyroid hormone


Input: This article discusses the possibility that simultaneous use of valproic acid, lamotrigine, and phenytoin could give this combination of toxicities and that concurrent viral infection may increase this risk.

give

toxicities

concurrent viral infection

valproic acid, lamotrigine, and phenytoin

valproic acid

lamotrigine

phenytoin

valproic acid

lamotrigine

phenytoin


Input: A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.

showed

postprandial hyperglycemia

betamethasone valerate cream 0.1%

betamethasone valerate

cream


Input: Phenytoin-induced hypersensitivity reactions.

induced

hypersensitivity reactions.

Phenytoin

Phenytoin


Input: A 54-year-old man developed TEN 4 weeks after beginning lamotrigine for complex partial seizures related to a glioblastoma multiforme brain tumor.

developed

A 54-year-old man

complex partial seizures related to a glioblastoma multiforme brain tumor

man

glioblastoma multiforme brain tumor

TEN

4 weeks after beginning lamotrigine

4 weeks

lamotrigine

complex partial seizures


Input: The occurrence of acute hepatitis is best known for ketoconazole.

for

acute hepatitis

ketoconazole

ketoconazole


Input: Optic neuropathy developed in a patient with rheumatoid arthritis who had been receiving D-penicillamine for about 1 year.

developed

a patient with rheumatoid arthritis

Optic neuropathy

D-penicillamine for about 1 year

rheumatoid arthritis

D-penicillamine

1 year


Input: Stupor and fast activity on electroencephalography in a child treated with valproate.

with

a child

child

Stupor

fast activity on electroencephalography

valproate

valproate


Input: During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.

developed

she

she

palmar pruritus, urticaria, and edema

cisplatin 100 mg/m2 over 30 minutes

30 minutes

100 mg/m2

cisplatin


Input: The case of a patient with infectious mononucleosis treated with cephalexin who later showed a rash is presented and the previous literature is reviewed.

showed

a patient with infectious mononucleosis

rash

cephalexin

cephalexin

infectious mononucleosis


Input: After 1 week of nefazodone therapy the patient experienced headache, confusion, and "gray areas" in her vision, without abnormal ophthalmologic findings.

experienced

patient

her

her

headache, confusion, and "gray areas" in her vision, without abnormal ophthalmologic findings

After 1 week of nefazodone therapy

1 week

nefazodone


Input: Nitrofurantoin-induced pulmonary toxicity during pregnancy: a report of a case and review of the literature.

induced

pulmonary toxicity

Nitrofurantoin

Nitrofurantoin


Input: Methylphenidate-associated enuresis in attention deficit hyperactivity disorder.

associated

enuresis

Methylphenidate

Methylphenidate


Input: To our knowledge, this is the first case report that demonstrates the occurrence of fever with low-dose amifostine therapy without the manifestation of accompanying rash or hypotension.

occurrence

the first case

fever

low-dose amifostine

low-dose

amifostine


Input: Administration of excessive insulin induced hypoglycemia within 4 to 8 hours, followed by rebound hyperglycemia.

induced

hypoglycemia

rebound hyperglycemia

Administration of excessive insulin

insulin

excessive

4 to 8 hours


Input: In both cases, symptoms of autonomic instability and severe agitation started within hours of initiation of cyclobenzaprine and fully resolved within 3 days after discontinuing the proserotoninergic drugs.

started

symptoms of autonomic instability and severe agitation

within hours of initiation of cyclobenzaprine

cyclobenzaprine

within hours of initiation


Input: Secondary leukemia in a child with neuroblastoma while on oral etoposide: what is the cause?

in

a child with neuroblastoma

child

Secondary leukemia

oral etoposide

neuroblastoma

oral

etoposide


Input: Atorvastatin induced multiple organ failure.

induced

multiple organ failure

Atorvastatin

Atorvastatin


Input: While serotonin syndrome has become more frequent in an overdose situation and when an interacting drug is given, the toxicity of SSIRs is less than that of most other psychiatric drugs.

toxicity

serotonin syndrome

SSIRs

SSIRs


Input: A 73-year-old woman with non-Hodgkin's lymphoma had two episodes of severe, bilateral, sensori-neural hearing loss after vincristine therapy.

after

A 73-year-old woman with non-Hodgkin's lymphoma

woman

two episodes of severe, bilateral, sensori-neural hearing loss

vincristine therapy

vincristine

non-Hodgkin's lymphoma


Input: Severe hemolytic uremic syndrome in an advanced ovarian cancer patient treated with carboplatin and gemcitabine.

in

an advanced ovarian cancer patient

Severe hemolytic uremic syndrome

carboplatin and gemcitabine

ovarian cancer

carboplatin

gemcitabine

carboplatin

gemcitabine


Input: Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment.

after

Ulcerative proctitis in juvenile systemic lupus erythematosus

ibuprofen

ibuprofen


Input: Acute asthma associated with sustained-release verapamil.

associated

Acute asthma

sustained-release verapamil

sustained-release verapamil


Input: The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor.

implicate

three patients

three

renal insufficiency

seizures

accumulation of ofloxacin

ofloxacin


Input: Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin.

in

a patient

Hemolytic uremic syndrome

cis-platinum, vinblastine and bleomycin

cis-platinum

vinblastine

bleomycin


Input: A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia.

following

15 patients

acute hemoglobinemia or hemoglobinuria

anti-D IGIV

ITP or secondary thrombocytopenia

anti-D IGIV

administration


Input: Amiodarone was discontinued, and thyrotoxicosis gradually abated.

was discontinued,

thyrotoxicosis gradually abated

Amiodarone

Amiodarone


Input: De novo absence status of late onset following withdrawal of lorazepam: a case report.

following

De novo absence status of late onset

withdrawal of lorazepam

lorazepam


Input: Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.

associated

two HIV-infected adolescent males

two

adolescent

males

nephrotoxicity

Tenofovir

Tenofovir

HIV-infected


Input: Reports of colonic perforation as a result of the administration of calcium polystyrene sulfonate and sorbitol are rare.

result

colonic perforation

calcium polystyrene sulfonate

sorbitol

calcium polystyrene sulfonate

sorbitol

the administration

calcium polystyrene sulfonate

sorbitol


Input: Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.

of

neurotoxic effects

ofloxacin

ofloxacin


Input: Atypical neuroleptic malignant syndrome associated with olanzapine.

associated

Atypical neuroleptic malignant syndrome

olanzapine

olanzapine


Input: OBJECTIVE: The authors described a case of interferon-induced psychosis as a framework to review the literature and discuss the decision to pursue antiviral treatment in psychiatrically ill patients with hepatitis C.

induced

psychiatrically ill patients with hepatitis C.

psychiatrically ill

psychosis

interferon

interferon

hepatitis C.


Input: We believe that methotrexate represents a relatively effective alternative to surgery in patients with early unruptured tubal pregnancy, but suggest that it be used with caution in view of possible systemic toxicity.

caution

patients with early unruptured tubal pregnancy

systemic toxicity

methotrexate

methotrexate

early unruptured tubal pregnancy


Input: After intravitreal injection of triamcinolone acetonide, cataract may rapidly develop in eyes that have been intensively treated, topically and systemically, by corticosteroids for several years.

develop

cataract

intravitreal injection of triamcinolone acetonide

intravitreal injection

triamcinolone acetonide


Input: Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection.

following

Acute endophthalmitis

intravitreal bevacizumab (Avastin) injection

intravitreal

injection

bevacizumab


Input: We report a case of bullous eruption, one month after starting nicardipine and lercanidipine.

after

bullous eruption,

starting nicardipine and lercanidipine.

one month

nicardipine

lercanidipine

nicardipine

lercanidipine


Input: Pulmonary fibrosis associated with nabumetone.

associated

Pulmonary fibrosis

nabumetone

nabumetone


Input: The ability of tumor necrosis factor (TNF)-alpha inhibitors to impair pivotal pro-inflammatory host defenses may facilitate the development of disseminated cryptococcosis.

development

disseminated cryptococcosis

tumor necrosis factor (TNF)-alpha inhibitors

tumor necrosis factor (TNF)-alpha inhibitors


Input: This was accepted as evidence for propranolol being the cause of this conduction disorder.

cause

conduction disorder

propranolol

propranolol


Input: We report a third case of a 6-week-old infant with Escherichia coli sepsis who received ampicillin and other antibiotics and subsequently developed TEN.

developed

6-week-old infant with Escherichia coli sepsis

infant

TEN

received ampicillin and other antibiotics

ampicillin

other antibiotics

Escherichia coli sepsis

ampicillin

other antibiotics


Input: PURPOSE: To report a case of bilateral anterior uveitis associated with ovulation induction therapy using clomiphene citrate.

associated

case

bilateral anterior uveitis

ovulation induction therapy using clomiphene citrate

clomiphene citrate


Input: A 57-year-old woman presented with a 3-week history of dysphagia for solids, 6 months after starting treatment with nifedipine.

presented

A 57-year-old woman

woman

dysphagia for solids

nifedipine

6 months

nifedipine


Input: Although combinations of belladonna, ergotamine, and phenobarbital have been used for medical treatment of menopausal symptoms since the 1960s, this is the first known case report of its association with anticonvulsant hypersensitivity syndrome.

association

anticonvulsant hypersensitivity syndrome

combinations of belladonna, ergotamine, and phenobarbital

belladonna

ergotamine

phenobarbital

menopausal symptoms

belladonna

ergotamine

phenobarbital


Input: Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.

associated

hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia

Rifampin

Rifampin


Input: It is believed that this is the first reported case of reversible azathioprine-induced cholestasis associated with histological evidence of bile duct injury.

induced

cholestasis

azathioprine

azathioprine


Input: We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.

associated

diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression

methanol

methanol


Input: Patients with inoperable or metastatic colorectal cancer were randomized to receive monthly FU 400 mg/m2/day plus LV 20 mg/m2/day as intravenous push daily for five days, or FU alone.

receive

Patients with inoperable or metastatic colorectal cancer

monthly FU 400 mg/m2/day plus LV 20 mg/m2/day as intravenous push daily for five days

metastatic colorectal cancer

inoperable

400 mg/m2/day

20 mg/m2/day

FU

LV

intravenous push

daily

monthly

five days

FU

LV


Input: The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.

induces

carbamazepine

increased plasma carbamazepine concentrations

carbamazepine toxicity.

clarithromycin

carbamazepine

carbamazepine

clarithromycin


Input: In this case, interferon alpha induced polymyositis and cardiomyopathy is diagnosed in a 33-yr-old male patient with history of chronic hepatitis B.

induced

a 33-yr-old male patient with history of chronic hepatitis B.

male

polymyositis and cardiomyopathy

interferon alpha

interferon alpha

history of chronic hepatitis B.


Input: To describe the potential for interaction between opioids and serotonergic antidepressants leading to the development of serotonin syndrome (SS), mechanism of the interaction, and the spectrum of SS in elderly residents of a long-term care facility.

leading

elderly residents

elderly

serotonin syndrome

opioids

serotonergic antidepressants

opioids

serotonergic antidepressants

opioids

serotonergic antidepressants


Input: Erythema multiforme bullosum due to rifampicin.

due

Erythema multiforme bullosum

rifampicin

rifampicin


Input: We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.

developed

a patient with acute leukemia

Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death

high-dose cytosine arabinoside.

acute leukemia

cytosine arabinoside

high-dose


Input: This profile should trigger a "red flag" as to the possibility of phenobarbital behavioral side effects or exacerbation of preexisting maladaptive behaviors.

trigger

behavioral side effects or exacerbation of preexisting maladaptive behaviors

phenobarbital

phenobarbital


Input: Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C.

occur

patients with chronic hepatitis C.

Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots

interferon

8 weeks

interferon

chronic hepatitis C.


Input: Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.

induced

pneumonitis

Rapamycin/sirolimus

Rapamycin

sirolimus

Rapamycin

sirolimus


Input: IFNalpha-induced recurrence of Graves' disease ten years after thyroidectomy in chronic viral hepatitis C.

induced

recurrence of Graves' disease

IFNalpha

ten years after thyroidectomy

chronic viral hepatitis C.

IFNalpha


Input: Risperidone withdrawal-related respiratory dyskinesia: a case diagnosed by spirography and fibroscopy.

related

respiratory dyskinesia

Risperidone

Risperidone


Input: Paralytic ileus in patients undergoing bortezomib treatment has been reported, although a definite attribution to bortezomib administration has not been established.

reported,

patients

Paralytic ileus

bortezomib treatment

bortezomib


Input: Severe serotonin syndrome induced by mirtazapine monotherapy.

induced by

serotonin syndrome

mirtazapine monotherapy

mirtazapine


Input: Three days after starting fluconazole, she developed polyuria and polydipsia and was found to have severe hyperglycemia, which led to the diagnosis of Cushing syndrome.

developed

polyuria and polydipsia and was found to have severe hyperglycemia, which led to the diagnosis of Cushing syndrome

Three days after starting fluconazole

fluconazole

Three days


Input: Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case.

caused

patient

hypocalcemic tetany

fleet phospho-soda

alendronate sodium

fleet phospho-soda

alendronate sodium


Input: Observations in our patient suggest that the leukoencephalopathy that developed in previously reported patients who received 5-fluorouracil and levamisole may have been caused at least partly by levamisole.

caused

patients

leukoencephalopathy

levamisole

levamisole


Input: We describe the clinical response, as determined by increases in total Hb and decreased transfusion needs, in five patients with thalassemia intermedia treated with HU alone or in combination with SPB.

treated

in five patients with thalassemia intermedia

five

increases in total Hb and decreased transfusion needs

HU alone or in combination with SPB

HU

SPB

thalassemia intermedia

HU

SPB


Input: According to the Naranjo et al. adverse-reaction probability scale, enoxaparin was the probable cause of hepatotoxicity in this patient.

cause

this patient

hepatotoxicity

enoxaparin

enoxaparin


Input: This is the first reported case of hepatolithiasis during octreotide therapy.

during

hepatolithiasis

octreotide

octreotide


Input: Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective.

induced

thyrotoxicosis (AIT)

amiodarone

amiodarone


Input: Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.

developed

Six patients with no previous signs or symptoms suggestive of coronary artery disease

Six

acute coronary ischemia/infarction

cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy

cis-diamine-dichloroplatinum II

chemotherapy


Input: RESULTS: Replacing valproate with lamotrigine resulted in a decrease in serum testosterone concentrations in all 3 women.

resulted

all 3 women

women

a decrease in serum testosterone concentrations

Replacing valproate with lamotrigine

lamotrigine


Input: A 65-year-old woman, in the intensive care unit because of septic shock and acute renal failure, had a small-bowel obstruction due to Amphojel concretions.

due

A 65-year-old woman, in the intensive care unit because of septic shock and acute renal failure

septic shock

acute renal failure

woman

small-bowel obstruction

concretions

Amphojel

Amphojel


Input: After the first oral dose of propranolol, syncope developed together with atrioventricular block.

developed

syncope

atrioventricular block

oral dose of propranolol

oral

propranolol


Input: Sorafenib induced tumor lysis syndrome in an advanced hepatocellular carcinoma patient.

induced

an advanced hepatocellular carcinoma patient

tumor lysis syndrome

Sorafenib

Sorafenib

hepatocellular carcinoma


Input: The symptoms did not recur during the 36 months of itraconazole treatment after discharge, and it was concluded that ITCZ was effective for A. flavus hypertrophic pachymeningitis.

effective

The symptoms did not recur

the 36 months of itraconazole treatment after discharge

A. flavus hypertrophic pachymeningitis

36 months

itraconazole


Input: A prospective randomized clinical trial was implemented to assess whether the concomitant or the sequential addition of tamoxifen to chemotherapy provides improved clinical benefit in the adjuvant treatment of breast cancer in postmenopausal patients.

provides

postmenopausal patients

postmenopausal

improved clinical benefit in the adjuvant treatment

the concomitant or the sequential addition of tamoxifen to chemotherapy

tamoxifen

chemotherapy

breast cancer


Input: Increased libido in a woman treated with fluvoxamine: a case report.

in

a woman

woman

Increased libido

fluvoxamine

fluvoxamine


Input: In the following case report, a patient developed acute interstitial nephritis with renal failure and exfoliative dermatitis following ampicillin therapy.

developed

patient

acute interstitial nephritis with renal failure and exfoliative dermatitis

ampicillin therapy

ampicillin


Input: Severe symptoms associated with serotonin toxicity were shown to be uncommon in patients receiving linezolid and selected serotonin reuptake inhibitors.

receiving

patients

Severe symptoms associated with serotonin toxicity

linezolid and selected serotonin reuptake inhibitors

serotonin

linezolid

serotonin reuptake inhibitors

linezolid

serotonin reuptake inhibitors


Input: We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.

of

colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit

mucositis

desquamating dermatitis

myelosuppression

neurologic toxicity

side effects

colon cancer


Input: There have been many reports of probable lithium-induced organic brain syndromes occurring when serum lithium levels are within or close to the therapeutic range.

induced

organic brain syndromes

lithium

when serum lithium levels are within or close to the therapeutic range

lithium


Input: The patient was enrolled in a weight-loss clinic, and his diabetes medications were adjusted.Subsequently, olanzapine was discontinued because of weight gain and uncontrolled diabetes.

because

patient

weight gain and uncontrolled diabetes

olanzapine was discontinued

olanzapine


Input: While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.

induced

thrombocytopenia and skin necrosis

heparin

heparin


Input: Gefitinib (IRESSA, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, has been approved in several countries for the treatment of advanced non-small-cell lung cancer.

treatment

Gefitinib

advanced non-small-cell lung cancer

Gefitinib

IRESSA

epidermal growth factor receptor tyrosine kinase inhibitor


Input: The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported.

induced

a 4-year-old girl

girl

stupor and electroencephalographic pattern of increased fast activity

valproate

valproate


Input: Prior to surgery, levodopa induced dyskinesia had improved (< or = 50%) under treatment with amantadine (400 mg/day, po) in all three patients.

improved

all three patients

three

levodopa induced dyskinesia

treatment with amantadine (400 mg/day, po)

amantadine

400 mg/day


Input: Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.

induced

hypomagnesemia and other electrolyte disorders

Foscarnet

Foscarnet


Input: A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.

following

child with fatal pulmonary fibrosis

child

fatal pulmonary fibrosis

BCNU therapy

BCNU


Input: A 64-year-old man with schizophrenia developed myoclonic jerks when given higher doses of quetiapine.

developed

A 64-year-old man with schizophrenia

man

myoclonic jerks

higher doses of quetiapine

schizophrenia

quetiapine

higher doses


Input: The etiology of neurotoxicity in our two patients remains unclear; however, as CAP is rapidly metabolized to 5-FU in patients with normal liver function, it is likely that 5-FU or its active metabolites (fluoro-beta-alanine) were contributing factors.

contributing

two patients

two

neurotoxicity

5-FU or its active metabolites (fluoro-beta-alanine)

fluoro-beta-alanine


Input: CONCLUSIONS: Amantadine can cause reversible corneal edema but can irreversibly reduce the density of endothelial cells.

cause

reversible corneal edema

Amantadine

Amantadine


Input: After gastric-outlet obstruction was recognized in several infants who received prostaglandin E1, we studied the association between the drug and this complication.

received

several infants

infants

gastric-outlet obstruction

prostaglandin E1

prostaglandin E1


Input: A wide variety of adverse central nervous system effects have been reported in association with propafenone; dizziness is the most common.

association

adverse central nervous system effects

dizziness

propafenone

propafenone


Input: Iatrogenic Cushing syndrome has been reported in patients with CF treated concomitantly, and for extended duration, with inhaled corticosteroids and CYP3A4 inhibitors.

reported

patients with CF

CF

Iatrogenic Cushing syndrome

inhaled corticosteroids and CYP3A4 inhibitors

inhaled

corticosteroids

CYP3A4 inhibitors

corticosteroids

CYP3A4 inhibitors


Input: Red blood cell anemia in a patient with pemphigus vulgaris induced by the use of mycophenolate mofetil and prednisone.

induced

a patient with pemphigus vulgaris

Red blood cell anemia

mycophenolate mofetil and prednisone

pemphigus vulgaris

mycophenolate mofetil

prednisone

mycophenolate mofetil

prednisone


Input: Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.

by

a patient with rheumatoid arthritis

systemic lupus erythematosus

interferon-gamma

interferon-gamma

rheumatoid arthritis.


Input: In this case, unlike those previously reported, hyponatremia recurred 5 months after switching from citalopram to mirtazapine, which is believed to be a safe antidepressant.

after

hyponatremia

switching from citalopram to mirtazapine

citalopram

mirtazapine

5 months


Input: This report describes a case of acute compromise of renal function associated with hypotension in a 7-year-old boy treated with the ACE inhibitor lisinopril and the ARB losartan.

associated

a 7-year-old boy

boy

acute compromise of renal function

hypotension

ACE inhibitor lisinopril and the ARB losartan

lisinopril

losartan

lisinopril

losartan


Input: We report a male patient with advanced AIDS who developed hypercalcemia 2 weeks after institution of rhGH therapy.

developed

a male patient with advanced AIDS

male

hypercalcemia

2 weeks after institution of rhGH therapy

advanced AIDS

rhGH

2 weeks


Input: RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.

associated

Both patients

Both

falling backward

bupropion

bupropion


Input: A second episode of jaundice followed the intravaginal administration of a mixture of furazolidone and nifuroxime.

followed

jaundice

intravaginal administration of a mixture of furazolidone and nifuroxime

furazolidone

nifuroxime

intravaginal

furazolidone

nifuroxime


Input: Clinicians should be aware that an erythematous and exfoliative rash may be induced by temozolomide, and be familiar with the pharmacologic and supportive measures necessary for its treatment.

induced

an erythematous and exfoliative rash

temozolomide

temozolomide


Input: Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21.

induced

two cardiac patients with trisomy 21

two

cardiac

trisomy 21

bone marrow suppression

Captopril

Captopril


Input: A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate (5 mg).

presented

A 65-year-old woman with angina pectoris

woman

syncope

sublingual ingestion of isosorbide dinitrate (5 mg)

angina pectoris

sublingual ingestion

isosorbide dinitrate

5 mg


Input: The authors present a case study of a mentally healthy man who repeatedly experienced short-lived, obsessional-like suicidal ideas and images after ingestion of the anti-fungal drug ketoconazole.

experienced

a mentally healthy man

man

short-lived, obsessional-like suicidal ideas and images

ingestion of the anti-fungal drug ketoconazole

ingestion

ketoconazole


Input: Flaccid quadriparesis was noted after discontinuation of vecuronium.

noted

Flaccid quadriparesis

vecuronium

vecuronium


Input: AIMS: The aim of this study was to report on the effectiveness and tumor side effects of topical interferon (INF) alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia (CIN) of a patient that rejected any surgical procedure.

side effects

conjunctiva-cornea intraepithelial neoplasia (CIN) of a patient that rejected any surgical procedure

tumor side effects

topical interferon (INF) alpha 2-beta

topical

interferon

alpha 2-beta

conjunctiva-cornea intraepithelial neoplasia


Input: Herein is reported an unusual case of coexistent warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for thromboembolic phenomena associated with marantic endocarditis and bronchial adenocarcinoma.

induced

skin necrosis

warfarin

warfarin


Input: We present a case of severe unilateral posterior scleritis associated with zoledronic acid administration that was recognized and treated in a timely manner.

associated

severe unilateral posterior scleritis

zoledronic acid

zoledronic acid


Input: The patient's other comorbidities and medications have not been suggested as possible interactions with sertraline that can cause rhabdomyolysis.

cause

rhabdomyolysis

sertraline

sertraline


Input: L-asparaginase-provoked seizures as singular expression of central nervous toxicity.

provoked

seizures as singular expression of central nervous toxicity

L-asparaginase

L-asparaginase


Input: Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan).

following

patients with ovarian carcinoma

Acute non-lymphocytic leukemia

long-term treatment with Treosulfan (= dihydroxybusulfan)

Treosulfan

ovarian carcinoma


Input: Children treated with thalidomide should undergo regular neurophysiologic studies in order to detect presymptomatic or progressive peripheral neuropathy.

detect

Children

Children

presymptomatic or progressive peripheral neuropathy

thalidomide

thalidomide


Input: Nevirapine is a non-nucleoside reverse transcriptase inhibitor widely used in combination with other antiretroviral agents for the treatment of HIV infection.

treatment

Nevirapine is a non-nucleoside reverse transcriptase inhibitor widely used in combination with other antiretroviral agents

Nevirapine

other antiretroviral agents

HIV infection

Nevirapine

other antiretroviral agents


Input: The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment.

developed

a 72-year-old man with hormone-refractory prostate cancer

man

subacute interstitial pneumonitis-related pulmonary fibrosis

and died

weekly administration of 30 mg/m2 docetaxel

seven doses

despite mechanical ventilation and high-dose corticosteroid treatment

weekly

administration

30 mg/m2

seven doses

high-dose

docetaxel

corticosteroid

hormone-refractory prostate cancer


Input: In this case, it was suspected that a combination of cigarette smoking, pulmonary fibrosis, and low-dose methotrexate therapy might have promoted the development of lung cancer.

promoted

pulmonary fibrosis

pulmonary fibrosis

the development of lung cancer

low-dose methotrexate therapy

low-dose

methotrexate


Input: Rapid onset of iatrogenic adrenal insufficiency in a patient with cystic fibrosis-related liver disease treated with inhaled corticosteroids and a moderate CYP3A4 inhibitor.

onset

a patient with cystic fibrosis-related liver disease

cystic fibrosis-related liver disease

iatrogenic adrenal insufficiency

inhaled corticosteroids and a moderate CYP3A4 inhibitor

inhaled corticosteroids

CYP3A4 inhibitor.

inhaled corticosteroids

CYP3A4 inhibitor.


Input: Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.

associated

thrombocytopenia and thrombosis

Heparin

Heparin

heparin


Input: The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.

disappeared

2 of the women

women

polycystic changes disappeared from the ovaries

lost weight and resumed menstruating

after valproate therapy was discontinued

valproate


Input: The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.

induced

thrombocytopoaenia

chronic ingestion of quinine

ingestion

quinine


Input: The concomitant use of antidepressant drugs associated with lithium as a co-adjuvant seems to increase the risk of this adverse reaction.

increase

adverse reaction

concomitant use of antidepressant drugs associated with lithium as a co-adjuvant

antidepressant drugs

lithium

antidepressant drugs

lithium


Input: Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported.

caused

Peripheral nervous system disturbances

cytosine arabinoside

cytosine arabinoside


Input: We report an unusually short lived and asymptomatic episode of severe cisplatin-induced renal tubular salt wasting in a fit 41-year-old patient with malignant teratoma.

induced

a fit 41-year-old patient with malignant teratoma

renal tubular salt wasting

cisplatin

malignant teratoma

cisplatin


Input: This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.

cause

This case

reversible encephalopathy syndrome

BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine)

BH-AC


Input: She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.

developed

agitation, dysarthria, diaphoresis, and a movement disorder

metoclopramide

metoclopramide

nausea

within 2 hours


Input: This article describes two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, and one case of agranulocytosis related to the use of methazolamide.

induced

two cases

aplastic anemia

methazolamide

methazolamide


Input: Amprenavir is a human immunodeficiency virus-1 (HIV-1) protease inhibitor intended to be used to treat HIV-infected children.

treat

children

children

Amprenavir

HIV-infected

Amprenavir


Input: Methotrexate-induced papular eruption following treatment of psoriasis has not been previously reported.

induced

papular eruption

Methotrexate

Methotrexate


Input: On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.

developed

the patient

pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level

hepatitis

linezolid

linezolid


Input: We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor.

treated with

a patient

for a brain tumor

acute interstitial pneumonitis

carmustine (BCNU)

carmustine (BCNU)

a brain tumor


Input: The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury.

lead

three reported cases

three

irreversible liver injury

troglitazone

troglitazone


Input: High-grade atrioventricular block during dipyridamole stress testing.

during

High-grade atrioventricular block

dipyridamole stress testing

dipyridamole


Input: We describe a case of intraoperative gelatine-induced anaphylaxis whose diagnosis was delayed as the use of gelatine during surgical procedures was omitted for two times in patient's medical records.

induced

anaphylaxis

intraoperative gelatine

gelatine

intraoperative


Input: The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is presented.

got

a 29-year-old man suffering from falciparum malaria disease

man

reversible hearing loss

quinine

falciparum malaria disease

quinine


Input: The cases of two asthmatic patients who became hypokalemic after inhalation of normal doses of albuterol are presented.

after

two asthmatic patients

two

hypokalemic

inhalation of normal doses of albuterol

asthmatic

inhalation

normal doses

albuterol


Input: This article presents a case of an atypical localized cutaneous eruption with an unusual course and protracted resolution time associated with sorafenib therapy.

associated with

an atypical localized cutaneous eruption with an unusual course and protracted resolution time

sorafenib therapy

sorafenib


Input: METHOD: We describe two patients who presented with diabetic ketoacidosis after treatment with quetiapine and risperidone, respectively.

presented

two patients

two

diabetic ketoacidosis

quetiapine and risperidone

quetiapine

risperidone


Input: We suspect that nefazodone inhibits metabolism of tacrolimus.

inhibits

metabolism of tacrolimus

nefazodone

nefazodone


Input: Our review of 194 RA patients and 38 PsA patients receiving MTX has identified four RA patients and one PsA patient with MTX-induced pneumonitis, giving a prevalence of 2.1% and 0.03%, respectively.

induced

194 RA patients and 38 PsA patients receiving MTX has identified four RA patients and one PsA patient

four

one

pneumonitis

MTX

RA

PsA

MTX


Input: A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient.

induced

an Indian mid-borderline leprosy patient

Indian

mid-borderline leprosy

agranulocytosis

dapsone

dapsone


Input: Autoimmune thyroid disease is a common side-effect of interferon-alpha (IFN-alpha) treatment of viral hepatitis C.

side-effect

Autoimmune thyroid disease

interferon-alpha (IFN-alpha)

interferon-alpha

viral hepatitis C.


Input: The side effects of MMF, such as bone marrow toxicity, have been reported.

reported.

bone marrow toxicity

MMF

MMF


Input: He developed a late secondary infection in some sites treated with imiquimod.

developed

He

He

late secondary infection

imiquimod

imiquimod


Input: We report the case of a 51-year-old man in whom IFN-alpha treatment was followed by recurrence of Graves' disease 10 years after thyroidectomy was performed and the patient was declared cured.

followed

a 51-year-old man

man

recurrence of Graves' disease

IFN-alpha treatment

10 years after thyroidectomy

IFN-alpha


Input: We report 2 cases of maculopapular eruption and fever in patients infected with human immunodeficiency virus (HIV) on the 2nd day of first administration of ritonavir, a protease inhibitor.

infected

patients

maculopapular eruption and fever

ritonavir

human immunodeficiency virus

ritonavir

2nd day of first administration


Input: We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine.

developed

a woman

woman

photo-onycholysis on multiple nails

uptake of olanzapine

olanzapine

after uptake


Input: Cimetidine is a rare cause of drug-induced fever.

cause

fever

Cimetidine

Cimetidine


Input: Reversible methotrexate-associated lymphoproliferative disorder resembling advanced gastric cancer in a patient with rheumatoid arthritis.

associated

a patient with rheumatoid arthritis

lymphoproliferative disorder

methotrexate

rheumatoid arthritis

methotrexate


Input: The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.

persist

field defects and some electrophysiological abnormalities persist

vigabatrin therapy is withdrawn

vigabatrin


Input: A possible case of carbamazepine induced pancreatitis.

induced

A possible case

pancreatitis

carbamazepine

carbamazepine


Input: Subsequent to the first dose of mirtazapine the patient experienced seizures, bradycardia and prolonged QRS as well as QTc intervals on EKG.

Subsequent

the patient

seizures, bradycardia and prolonged QRS as well as QTc intervals on EKG

mirtazapine

mirtazapine


Input: Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.

in

a patient with protein C deficiency

Stuttering priapism

warfarin

protein C deficiency

warfarin


Input: She had been on a combined treatment of steroid and lobenzarit disodium for the first 3 years, and then continued with a combined treatment of steroid and bucillamine for the following years until she was found to have pulmonary tuberculosis, at which time the steroid was suspended 10 months before she visited the authors' clinic.

treatment

pulmonary tuberculosis

steroid and lobenzarit disodium for the first 3 years, and then continued with a combined treatment of steroid and bucillamine for the following years

steroid

bucillamine

lobenzarit disodium

steroid

3 years

for the following years

steroid

bucillamine

lobenzarit disodium

steroid


Input: We describe a rare case of severe drug-drug interaction between propafenone and mirtazapine leading to propafenone toxicity.

leading

a rare case

propafenone toxicity

propafenone and mirtazapine

propafenone

mirtazapine

propafenone

mirtazapine


Input: Because the combination of bleomycin and vinca alkaloids is commonly used for the treatment of AIDS-related Kaposi's sarcoma, clinicians should be aware of the risk of provoking acral necrosis in patients who develop Raynaud's phenomenon under chemotherapy.

provoking

acral necrosis

Raynaud's phenomenon

bleomycin

vinca alkaloids

bleomycin

vinca alkaloids

bleomycin

vinca alkaloids


Input: The psychotic behavior resolved completely soon after the discontinuation of levetiracetam.

resolved

discontinuation of levetiracetam

psychotic behavior

soon after

levetiracetam


Input: Male volunteers ( n=12) participated in a randomised, two-period, crossover trial evaluating the effect of multiple doses of 600 mg rifampicin once daily for 7 days on repaglinide metabolism.

on

Male volunteers ( n=12)

Male

repaglinide metabolism

multiple doses of 600 mg rifampicin once daily for 7 days

multiple doses of 600 mg

rifampicin

once daily

7 days


Input: This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.

due

anemia

MMF

prednisone

MMF

prednisone

MMF

prednisone


Input: Warfarin was initiated for deep vein thrombosis prophylaxis due to the patient's inability to ambulate.

prophylaxis

patient's inability to ambulate

inability to ambulate

Warfarin was initiated for deep vein thrombosis

deep vein thrombosis

Warfarin


Input: We report a case with chronic hepatitis C (CHC) who developed sarcoidosis after the treatment by interferon alpha and ribavirin.

developed

sarcoidosis

treatment by interferon alpha and ribavirin

chronic hepatitis C (CHC)

interferon alpha

ribavirin

interferon alpha

ribavirin


Input: The relation between tacrolimus treatment and staining was suggested by the appearance of pigmentation during topical tacrolimus treatment and its clinical disappearance when treatment was stopped.

during

appearance of pigmentation

topical tacrolimus

tacrolimus

topical


Input: Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.

induced

bradycardia

clonidine

clonidine


Input: Several hypersensitivity reactions to cloxacillin have been reported, although IgE-mediated allergic reactions to the drug are rare and there is little information about possible tolerance to other semisynthetic penicillins or cephalosporins in patients with cloxacillin allergy.

reactions to

hypersensitivity

cloxacillin

cloxacillin


Input: Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome.

induced

patient with Wolff-Parkinson-White syndrome

Brugada type electrocardiographic changes

concomitant use of lithium and propafenone

Wolff-Parkinson-White syndrome

lithium

propafenone

lithium

propafenone


Input: Docetaxel-induced Meibomian duct inflammation and blockage leading to chalazion formation.

induced

Meibomian duct inflammation and blockage leading to chalazion formation

Docetaxel

Docetaxel


Input: Allergic side effects of AZA are rare, and reported allergic skin eruptions from AZA are very limited in Japan.

from

allergic skin eruptions

AZA

AZA


Input: Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.

induced

obsessive-compulsive symptoms (OCS)

OCS

antipsychotic

antipsychotic


Input: Outcome of pregnancy in women treated with all-trans retinoic acid; a case report and review of literature.

treated

pregnancy in women

women

all-trans retinoic acid

all-trans retinoic acid

pregnancy


Input: The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.

development

patients

SJS/TEN, a severe life-threatening illness

TMP-Sx

SSTIs

TMP

Sx

TMP

Sx


Input: A case history of a 15-year-old boy who developed incapacitating tardive dyskinesia that resolved during treatment with deanol is presented.

resolved

a 15-year-old boy

boy

incapacitating tardive dyskinesia

deanol

deanol


Input: Drug-induced mammary hyperplasias have been reported as rare complications of D-penicillamine and Neothetazone.

induced

mammary hyperplasias

Drug

D-penicillamine and Neothetazone

Drug

Neothetazone

D-penicillamine

D-penicillamine

Neothetazone


Input: The purpose of this report is to document a new case of in utero CP exposure with multiple congenital anomalies and to establish an apparent CP embryopathy phenotype.

exposure

multiple congenital anomalies

CP embryopathy

CP

CP


Input: AIM: The aim of this article is to present the clinical characteristics and management of an oral adverse effect stemming from the use of the antiretroviral medication Nevirapine (NVP).

from

adverse effect

antiretroviral medication Nevirapine (NVP)

Nevirapine


Input: A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.

receiving

A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia

man

bronchial asthma

eosinophilic enteritis

eosinophilic pneumonia

fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia

trimethoprim (TMP)-sulfamethoxazole (SMX)

trimethoprim

sulfamethoxazole

two weeks after

sulfamethoxazole

trimethoprim


Input: Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.

produce

increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease

Treatment with infliximab

infliximab


Input: Serotonin syndrome, which occurs as a result of enhanced serotonin concentration in the central nervous system, is a well-known adverse effect of serotonin-active medications.

occurs

Serotonin syndrome,

serotonin-active medications


Input: Despite the risk of needle-track seeding, PEI remains useful in the treatment of HCC.

remains

PEI

PEI

HCC


Input: Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a pediatric patient.

induced

a pediatric patient

pediatric

hepatotoxicity

Trimethoprim-sulfamethoxazole

Trimethoprim

sulfamethoxazole

Trimethoprim

sulfamethoxazole


Input: Prolonged responses were achieved with low doses of HU (3-10 mg/kg/day) and higher doses were associated with mild reversible hematologic or hepatic toxicity and no further increases in Hb.

associated

mild reversible hematologic or hepatic toxicity and no further increases in Hb

HU (3-10 mg/kg/day) and higher doses

HU

higher doses


Input: Imidazoline intoxication in children.

intoxication

children

children

Imidazoline intoxication

Imidazoline

Imidazoline


Input: Concomitant administration of cytarabine might have affected his liver function and there might have been interaction between the drugs.

affected

liver function

cytarabine

cytarabine


Input: The probability of developing acute leukemia in this study was not significantly correlated to the total cumulative dosage of Treosulfan.

developing

acute leukemia

the total cumulative dosage of Treosulfan

Treosulfan


Input: Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients.

induced

two patients.

two

cerebrospinal fluid eosinophilia

Intraventricular vancomycin

Intraventricular

vancomycin


Input: This case supports the view that in gold-induced pneumonitis a prolonged treatment with corticosteroids may be necessary, as lung function continued to improve.

as

a prolonged treatment with corticosteroids

in gold-induced pneumonitis

gold

corticosteroids


Input: Massive plasmocytosis due to methimazole-induced bone marrow toxicity.

induced

bone marrow toxicity

Massive plasmocytosis

methimazole

methimazole


Input: RESULTS: After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses.

achieve

one patient

one

glucose levels of all patients increased and achieve criteria of diabetes diagnoses

6-month period of monotherapy with indapamide (2.5 mg/day)

indapamide

2.5 mg/day


Input: A reversible toxic liver damage was observed in a non-alcoholic woman treated with disulfiram.

damage

a non-alcoholic woman

non-alcoholic

woman

reversible toxic liver damage

disulfiram

disulfiram


Input: A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness after receiving a regular dosage of colchicine.

developed

A 60 year-old woman with chronic renal failure

60 year-old

woman

acute proximal muscle weakness

regular dosage of colchicine

chronic renal failure

colchicine

regular dosage


Input: The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.

related

prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth

niacin

niacin


Input: Nocardia is an important opportunistic infectious agent in immunocompromised hosts, i.e. in patients taking corticosteroids.

infectious agent

immunocompromised hosts

immunocompromised

Nocardia

corticosteroids

corticosteroids


Input: Hepatobiliary disorders associated with orally administered terbinafine have rarely been reported.

associated

Hepatobiliary disorders

orally administered terbinafine

terbinafine

orally


Input: We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).

provoked

a patient

generalized pustular psoriasis (GPP)

trazodone hydrochloride (Molipaxin, Roussel)

trazodone hydrochloride


Input: Early recognition of hereditary motor and sensory neuropathy type 1 can avoid life-threatening vincristine neurotoxicity.

can

Early recognition of hereditary motor and sensory neuropathy type 1


Input: Probable enoxaparin-induced hepatotoxicity.

induced

hepatotoxicity

enoxaparin

enoxaparin


Input: Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation.

associated

Interstitial pneumonitis

sirolimus

sirolimus


Input: He had also developed elevated serum ammonia levels while on valproic acid.

developed

He

He

elevated serum ammonia levels

valproic acid

valproic acid


Input: Cutaneous rashes and eruptions can be caused by many medications, including carbamazepine.

caused

Cutaneous rashes and eruptions

carbamazepine

carbamazepine


Input: In this case, the increase in the INR value with associated bruising after the addition of amoxycillin suggests a drug interaction between acenocoumarol and amoxycillin, other possible causes having been eliminated.

after

the increase in the INR value with associated bruising

amoxycillin

amoxycillin

acenocoumarol

amoxycillin

acenocoumarol

amoxycillin


Input: Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.

induce

serious interstitial lung disease

sorafenib

sorafenib

lung cancer


Input: SUMMARY: A 26-year-old man with bipolar disorder, seizures, and mild mental retardation secondary to a traumatic brain injury began treatment with carbamazepine for aggression and seizure control.

treatment

A 26-year-old man with bipolar disorder, seizures, and mild mental retardation secondary to a traumatic brain injury

bipolar disorder

seizures

mild mental retardation secondary to a traumatic brain injury

man

carbamazepine

carbamazepine

aggression

seizure


Input: Serotonin toxicity precipitated by fentanyl is unusual and has not previously been described in combination with SSRIs in the perioperative setting.

precipitated

Serotonin toxicity

fentanyl

fentanyl

SSRIs

fentanyl

SSRIs


Input: It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome.

cause

hypersensitivity syndrome

a severe adverse drug reaction

dapsone

dapsone


Input: Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.

after

Visual system side effects caused by parasympathetic dysfunction

botulinum toxin type B injections

botulinum toxin type B

injections


Input: Renal failure associated with acetazolamide therapy for glaucoma.

associated

Renal failure

acetazolamide therapy

acetazolamide

glaucoma


Input: Acute onset of nephrotic syndrome during interferon-alpha retreatment for chronic active hepatitis C.

during

Acute onset of nephrotic syndrome

interferon-alpha retreatment

interferon-alpha

chronic active hepatitis C.


Input: A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.

while

A 16-year-old boy

boy

fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels

olanzapine and lithium

olanzapine

lithium

olanzapine

lithium


Input: The hyperpigmentation was diffuse scattered, flagellate like and linear streaking which was thought to be mainly related to the skin toxicity of bleomycin.

toxicity

hyperpigmentation was diffuse scattered, flagellate like and linear streaking

bleomycin

bleomycin


Input: Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions.

toxicities

dermatologic toxicities


Input: Bowel perforation associated with intraperitoneal chromic phosphate instillation.

associated

Bowel perforation

intraperitoneal chromic phosphate instillation

intraperitoneal

instillation

chromic phosphate


Input: A 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate.

developed

A 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck

woman

a chemotherapy-related hemolytic-uremic syndrome

the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate

squamous cell carcinoma of the head and neck

second cycle

cisplatin

bleomycin

methotrexate

cisplatin

bleomycin

methotrexate


Input: These data confirm the therapeutic value of arsenic trioxide in relapsed/resistant APL.

therapeutic value

arsenic trioxide

relapsed/resistant APL


Input: Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy.

in

patients with prostate cancer

Avascular necrosis of the femoral head

cyproterone acetate and radiotherapy

prostate cancer

cyproterone acetate


Input: Ectropion secondary to bolus injection of 5-fluorouracil.

secondary

Ectropion

bolus injection of 5-fluorouracil

bolus injection


Input: Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.

induced

patients with renal failure

renal failure

parkinsonism

Metoclopramide

Metoclopramide


Input: Posterior reversible encephalopathy syndrome associated with methotrexate neurotoxicity: conventional magnetic resonance and diffusion-weighted imaging findings.

associated

Posterior reversible encephalopathy syndrome

methotrexate neurotoxicity

methotrexate


Input: A 6-year-old boy (weight: 16 kg, at the start of treatment) began sodium valproate (valproate syrup 5%) treatment for epilepsy in February 2012.

treatment

A 6-year-old boy (weight: 16 kg, at the start of treatment)

boy

sodium valproate (valproate syrup 5%)

epilepsy

sodium valproate


Input: Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.

in

children with acute lymphoblastic leukemia

children

myelotoxicity and therapeutic failure

acute lymphoblastic leukemia


Input: We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.

developed

identical twin brothers

brothers

leukoencephalopathy and hydrocephalus

intrathecally administered methotrexate

intrathecally administered methotrexate and cranial irradiation

methotrexate

methotrexate

intrathecally

intrathecally


Input: Considering the increasing use of TMZ, which is regarded as a drug with moderate toxicity, careful follow-up with routine blood testing is vital.

with

moderate toxicity

TMZ

TMZ


Input: While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.

prevent

antidepressants

changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha

antidepressants


Input: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.

associated

a case

serotonin syndrome

interaction between fentanyl and citalopram

fentanyl

citalopram

fentanyl

citalopram


Input: We report a case of ibuprofen-induced meningitis in an otherwise healthy individual.

induced

an otherwise healthy individual

meningitis

ibuprofen

ibuprofen


Input: The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.

shared

patient

growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly

in utero exposure to cyclosposphamide

cyclosposphamide


Input: L-Thyroxine-induced leukopenia in a patient with Hashimoto's disease: involvement of suppressor-cytotoxic T cells.

induced

a patient with Hashimoto's disease

leukopenia

L-Thyroxine

L-Thyroxine

Hashimoto's disease


Input: Carbamazepine-induced systemic lupus erythematosus-like disease.

induced

systemic lupus erythematosus-like disease

Carbamazepine

Carbamazepine


Input: CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.

in

an elderly patient

elderly

increase of INR

levamisole and 5-FU

warfarin

levamisole

warfarin

levamisole

warfarin


Input: These results suggest that the hepatoxicity of ethanol in alcoholic beverages is enhanced by interaction with its congeners and acetaldehyde; they also suggest that alcoholic beverages are not equivalent in their potential to cause liver damage.

enhanced

hepatoxicity

alcoholic

alcoholic


Input: The dermatology literature heretofore has not noted that anemia is a side effect of patients taking MMF to treat pemphigus.

is

patients

anemia

MMF

pemphigus


Input: The 9 other reported cases of D-penicillamine induced rapidly progressive glomerulonephritis have been reviewed.

induced

rapidly progressive glomerulonephritis

D-penicillamine

D-penicillamine


Input: We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant.

after

a heroin abuser

acute hepatitis B and C

subcutaneous naltrexone implant

heroin abuser

subcutaneous

naltrexone


Input: Ciprofloxacin-induced psychosis.

induced

psychosis

Ciprofloxacin

Ciprofloxacin


Input: Thalidomide was withdrawn from world markets in 1961 following recognition of its teratogenic effects.

following

teratogenic effects

Thalidomide

Thalidomide


Input: Weekly AUC2 carboplatin in acquired platinum-resistant ovarian cancer with or without oral phenoxodiol, a sensitizer of platinum cytotoxicity: the phase III OVATURE multicenter randomized study.

in

Weekly AUC2 carboplatin

with or without oral phenoxodiol

Weekly

AUC2 carboplatin

phenoxodiol

platinum-resistant ovarian cancer

oral

phenoxodiol

AUC2 carboplatin


Input: We suggest the use of esmolol for treatment of dysrhythmias secondary to caffeine toxicity; to the best of our knowledge, the use of esmolol has not been reported for this purpose.

treatment

esmolol

esmolol

caffeine

esmolol

dysrhythmias


Input: To date, there have been few reports of visual disturbances associated with BTX-B use.

associated

visual disturbances

BTX-B

BTX-B


Input: Gemcitabine is a known risk factor for hemolytic uremic syndrome (HUS), which can often have a rapidly fatal clinical course despite intervention with steroids, plasmapheresis and hemodialysis.

risk

hemolytic uremic syndrome

Gemcitabine

Gemcitabine


Input: Our objective is to present a retrospective analysis of the DWI findings in four patients who suffered subacute neurotoxicity after intrathecal MTX.

after

four patients

four

subacute neurotoxicity

intrathecal MTX

intrathecal MTX


Input: We report a case of ST elevation in right precordial leads compatible with type 1 Brugada syndrome following administration of propafenone in a patient with Wolff-Parkinson-White syndrome who was receiving lithium at concentrations within therapeutic levels.

following

a patient with Wolff-Parkinson-White syndrome

ST elevation in right precordial leads compatible with type 1 Brugada syndrome

administration of propafenone

receiving lithium at concentrations within therapeutic levels

propafenone

lithium

Wolff-Parkinson-White syndrome

propafenone

lithium


Input: The spectrum of cutaneous eruptions associated with dihydropyridines is extensive, varying from exanthemas to severe adverse events.

associated

cutaneous eruptions

exanthemas

dihydropyridines

dihydropyridines


Input: Polymyositis after propylthiouracil treatment for hyperthyroidism.

after

Polymyositis

propylthiouracil

propylthiouracil

hyperthyroidism


Input: Methamphetamine's extensive physiologic effects, inconsistent street purity, and multiple routes of administration offer many possibilities for injury to the cornea.

offer

Methamphetamine's

injury to the cornea

Methamphetamine's


Input: Since ethambutol is actively excreted via the renal system, compromise of renal function such as due to renal tuberculosis may lead to serum concentration elevations of ethambutol sufficient to produce optic neuropathy.

lead

serum concentration elevations of ethambutol sufficient to produce optic neuropathy

ethambutol

ethambutol


Input: Renal failure appeared 8 to 17 days after beginning gentamicin therapy and was characterized by creatinine clearances 4 to 10 ml/min, urine to plasma creatinine ratios less than 20, urinary sodium concentrations 16 to 60 mEq/liter, proteinuria, and cylindruria.

beginning

Renal failure

creatinine clearances 4 to 10 ml/min, urine to plasma creatinine ratios less than 20, urinary sodium concentrations 16 to 60 mEq/liter, proteinuria, and cylindruria

gentamicin therapy

8 to 17 days

gentamicin


Input: Seizures associated with ofloxacin therapy.

associated

Seizures

ofloxacin

ofloxacin


Input: Cutaneous seeding after ultrasound-guided percutaneous ethanol injection for treatment of hepatocellular carcinoma.

after

Cutaneous seeding

ultrasound-guided percutaneous ethanol injection

injection

ethanol

hepatocellular carcinoma


Input: Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.

after

Two patients

Mycobacterium avium-intracellulare infection

Two

decreased visual acuity

bitemporal visual field defects

optic chiasm damage

ethambutol

Mycobacterium avium-intracellulare infection

ethambutol


Input: CONCLUSIONS: Metoclopramide may cause reversible nonthrombocytopenic vascular-type palpable purpura.

cause

reversible nonthrombocytopenic vascular-type palpable purpura

Metoclopramide

Metoclopramide


Input: CONCLUSIONS: Life-threatening adrenal suppression, requiring hydrocortisone supplementation and intensive therapy, was observed and successfully treated in a newborn, whose mother had received high-dose methylprednisolone in late pregnancy.

requiring

a newborn, whose mother had received high-dose methylprednisolone in late pregnancy

newborn

successfully treated

hydrocortisone supplementation and intensive therapy

hydrocortisone


Input: A case of extrapyramidal symptoms (EPS) following administration of aripiprazole to a man with developmental disabilities who had never received antipsychotic medications and had no history of movement disorders is presented.

following

a man with developmental disabilities who had never received antipsychotic medications and had no history of movement disorders is presented

man

developmental disabilities

extrapyramidal symptoms (EPS)

aripiprazole

aripiprazole


Input: Although high-dose methotrexate has been shown to be useful in the treatment of primary osteogenic sarcoma, the tumoricidal effects of therapy appear to have caused a fatal rise in intracranial pressure.

caused

a fatal rise in intracranial pressure

high-dose methotrexate

primary osteogenic sarcoma

high-dose

methotrexate


Input: This case had radiation fibrosis, so we suggest that radiation fibrosis may be another contributor of the occurrence of ILD in patients taking erlotinib.

of

patients

occurrence of ILD

taking erlotinib

erlotinib


Input: Since recent studies have reported no negative interactions with concurrent use, we here report three cases (one case of a prolonged seizure, a serotonin syndrome and a focal seizure) of severe lithium-induced side effects while patients underwent ECT without complications and lithium serum levels were still subtherapeutic.

induced

a prolonged seizure

lithium

lithium


Input: Lithium-associated transient thyrotoxicosis in 4 Chinese women with autoimmune thyroiditis.

associated

4 Chinese women with autoimmune thyroiditis

Chinese

women

autoimmune thyroiditis

transient thyrotoxicosis

Lithium

Lithium


Input: A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain.

on

A patient

an episode of acute chest pain

intravenous ritodrine therapy

intravenous

ritodrine


Input: Subsequent in vivo/vitro studies clearly demonstrated that the neurological effects were due to a synergistic action of desferrioxamine and prochlorperazine, probably resulting in exceptional fluxes of intra/extra cellular iron/copper disturbing noradrenergic and serotonergic systems.

due

neurological effects

desferrioxamine and prochlorperazine

desferrioxamine

prochlorperazine

desferrioxamine

prochlorperazine


Input: Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.

outcome

after liver transplantation with lamivudine and adefovir therapy

lamivudine

adefovir

hepatitis B infection

lamivudine

adefovir


Input: Pemphigus foliaceus was seen in a patient with pulmonary tuberculosis during rifampicin therapy.

seen

a patient with pulmonary tuberculosis

Pemphigus foliaceus

rifampicin

pulmonary tuberculosis

rifampicin


Input: CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.

receiving

patients

serotonin syndrome with serious extrapyramidal reactions

sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose

sertraline

venlafaxine

metoclopramide

single, conventional dose

metoclopramide

venlafaxine

sertraline


Input: We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.

after

a patient

polyserositis (pericardial effusion, pleural effusion, and pericarditis)

started on clozapine

clozapine


Input: Three years later, treatment with ampicillin caused another episode of cholestatic hepatitis with cholestasis and duct paucity on rebiopsy.

caused

cholestatic hepatitis with cholestasis and duct paucity on rebiopsy

ampicillin

ampicillin

Three years later


Input: METHODS: A patient who developed dramatic, permanent vision loss after a 9-month course of treatment with ethambutol and isoniazid for pulmonary tuberculosis is presented.

after

A patient

permanent vision loss

9-month course of treatment with ethambutol and isoniazid

pulmonary tuberculosis

ethambutol

isoniazid

ethambutol

isoniazid


Input: The authors report a case of urinary incontinence (UI) that occurred in a woman after administration of venlafaxine.

occurred

a woman

woman

urinary incontinence (UI)

venlafaxine

venlafaxine


Input: The possibility can be raised that M-CSF accelerated the underlying renal disease in this case through enhancing macrophage accumulation into the glomerulus, leading to the development of nephrotic syndrome.

accelerated

underlying renal disease in this case through enhancing macrophage accumulation into the glomerulus, leading to the development of nephrotic syndrome

M-CSF

M-CSF


Input: We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants.

developed

two ELBW infants affected by hyperkalaemia

two

infants

ELBW

serious hypernatraemia

Kayexalate

hyperkalaemia

Kayexalate


Input: DISCUSSION: Electrolyte disorders associated with foscarnet are reviewed.

associated

Electrolyte disorders

foscarnet

foscarnet


Input: We report two cases that developed acute myeloid leukaemia (AML) during tamoxifen therapy for breast cancer.

developed

two cases

two

acute myeloid leukaemia (AML)

tamoxifen therapy for breast cancer

breast cancer

tamoxifen


Input: Our patient was a 72-year-old man with advanced Parkinson's disease (PD) who received levodopa and anti-cholinergic drugs and whose head had become almost completely bald.

become

a 72-year-old man with advanced Parkinson's disease (PD)

man

completely bald

levodopa and anti-cholinergic drugs

advanced Parkinson's disease (PD)

levodopa

anti-cholinergic drugs


Input: The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.

experienced

hallucinations, agitation, vomiting, tachycardia and seizures

ingestion of 1050 (48 mg/kg) of extended-release bupropion

ingestion

1050 (48 mg/kg)

bupropion


Input: This case report describes a 38-year-old male in whom SIADH was strongly suspected secondary to Tegretol therapy to control a seizure disorder.

suspected

38-year-old male

a seizure disorder

male

SIADH

Tegretol

Tegretol

seizure


Input: However, cyclosporine dependency is associated with the risk of nephrotoxicity.

associated

nephrotoxicity

cyclosporine dependency

cyclosporine


Input: The observations suggest that testicular swelling and pain are side effects of desipramine.

side effects

testicular swelling and pain

desipramine

desipramine


Input: METHOD: We describe three case-reports concerning haematological adverse effects of quetiapine.

adverse effects

haematological adverse effects

quetiapine

quetiapine


Input: Typically, drug-induced neutropenia occurs in a patient receiving a semisynthetic penicillin for two weeks or more.

occurs

a patient

drug-induced neutropenia

a semisynthetic penicillin for two weeks or more

semisynthetic penicillin

two weeks


Input: Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.

of

Peripheral nerve dysfunction

cytosine arabinoside

cytosine arabinoside

high-dose


Input: Tumor-volume increase at beginning of primary treatment with topical interferon alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia.

increase

a case of conjunctiva-cornea intraepithelial neoplasia

Tumor-volume increase

primary treatment with topical interferon alpha 2-beta

interferon alpha 2-beta

topical

beginning

conjunctiva-cornea intraepithelial neoplasia


Input: L-asparaginase-induced posterior reversible encephalopathy syndrome during acute lymphoblastic leukemia treatment in children.

induced

children

children

posterior reversible encephalopathy syndrome

L-asparaginase

L-asparaginase

acute lymphoblastic leukemia


Input: On the other hand, MTX-induced pneumonitis seems to be very rare in psoriatic arthritis (PsA).

induced

pneumonitis

MTX

MTX


Input: Ototoxicity as a result of cis-platinum administration is well documented.

result

Ototoxicity

cis-platinum administration

cis-platinum


Input: Massive subfascial hematoma after alteplase therapy for acute myocardial infarction.

after

Massive subfascial hematoma

alteplase therapy

alteplase

acute myocardial infarction


Input: We suggest that itraconazole should be added to the list of drugs that may be responsible for a drug-induced vanishing bile duct syndrome.

responsible

drug-induced vanishing bile duct syndrome

itraconazole

itraconazole


Input: A 67-year-old man receiving a stable maintenance dosage of warfarin experienced an increased international normalized ratio (INR) without bleeding when his atorvastatin therapy was switched to fluvastatin.

experienced

A 67-year-old man

man

increased international normalized ratio (INR)

warfarin

warfarin


Input: The cases of CBZ-induced SLE reported in the literature were reviewed.

induced

SLE

CBZ

CBZ


Input: Ciprofloxacin-induced hemorrhagic vasculitis.

induced

hemorrhagic vasculitis

Ciprofloxacin

Ciprofloxacin


Input: INTERPRETATION: When high doses of fluticasone propionate are used, growth may be retarded and adrenal suppression may occur.

occur.

growth may be retarded and adrenal suppression

high doses of fluticasone propionate

high doses

fluticasone propionate


Input: To our knowledge, this is the first report of significant hypotension associated with intravenous valproate in the treatment of status epilepticus in the pediatric population.

associated

pediatric population

pediatric

hypotension

intravenous valproate

valproate

intravenous

status epilepticus


Input: While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever.

developed

he

he

worsening diarrhea with abdominal pain and fever

albendazole

albendazole


Input: Linezolid-associated peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome.

associated

peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome.

Linezolid

Linezolid


Input: Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.

after

Bone marrow aplasia and severe skin rash

a single low dose of methotrexate

methotrexate

single low dose


Input: A woman 38-year-old, suffering for about ten years from multiple sclerosis and treated with repeated therapy cycles of intrathecal Depo-Medrol, developed a spastic paraparesis at the lower limbs.

developed

A woman 38-year-old, suffering for about ten years from multiple sclerosis

woman

a spastic paraparesis at the lower limbs

repeated therapy cycles of intrathecal Depo-Medrol

Depo-Medrol

multiple sclerosis

intrathecal

repeated


Input: The efficacy of single-dose disulfiram as an inhibitor of human P450 2E1 suggests that this modality for manipulating clinical P450 2E1 activity may provide a useful probe for delineating P450 2E1 participation in human drug biotransformation or for the treatment of poisoning by P450 2E1-activated toxins.

by

poisoning

P450 2E1-activated toxins

disulfiram

P450 2E1-activated toxins

single-dose


Input: To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.

presenting

25 additional patients with Wilson's disease

neurologic disease

penicillamine

penicillamine

Wilson's disease


Input: The authors present a case of t-AML that developed in a child with metastatic neuroblastoma 18 months after he received oral etoposide, given for palliation purpose.

after

a child with metastatic neuroblastoma

child

t-AML

oral etoposide

18 months

oral

etoposide

metastatic neuroblastoma


Input: Mechanisms and triggering factors of hypoglycaemia induced by mefloquine and some other anti-malarial quinine analogues are discussed.

induced

hypoglycaemia

mefloquine and some other anti-malarial quinine analogues

mefloquine

quinine analogues

mefloquine

quinine analogues


Input: Only nondepolarizing muscle relaxants should be used in patients who are at risk for mucositis.

used

patients who are at risk for mucositis

mucositis

nondepolarizing muscle relaxants

nondepolarizing muscle relaxants


Input: CONCLUSION: A possible pharmacokinetic interaction between Dantrolene and Oxybutynin should be borne in mind when considering Carbamazepine medication for a patient with a spinal cord lesion.

medication

a patient

Carbamazepine medication

a spinal cord lesion

Dantrolene

Oxybutynin

Carbamazepine

Dantrolene

Oxybutynin


Input: We describe a 15-year-old female patient diagnosed with acute lymphoblastic leukemia presenting with status epilepticus after receiving intrathecal methotrexate.

after

a 15-year-old female patient diagnosed with acute lymphoblastic leukemia

female

presenting with status epilepticus

receiving intrathecal methotrexate

intrathecal

methotrexate

acute lymphoblastic leukemia


Input: Duodenal ulceration: a complication of tolazoline therapy.

complication

Duodenal ulceration

tolazoline

tolazoline


Input: Hepatic damage after danazol treatment.

after

Hepatic damage

danazol

danazol


Input: Hepato-biliary abnormalities secondary to ceftriaxone use: a case report.

secondary to

Hepato-biliary abnormalities

ceftriaxone use

ceftriaxone


Input: Rhabdomyolysis with concurrent atorvastatin and diltiazem.

with

Rhabdomyolysis

diltiazem

atorvastatin

atorvastatin

diltiazem

atorvastatin

diltiazem


Input: Case report: mannitol nephrotoxicity syndrome: role of hemodialysis and postulate of mechanisms.

syndrome:

nephrotoxicity

mannitol

mannitol


Input: Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.

during

Uveitis

combination of rifabutin, clarithromycin and ethambutol

disseminated Mycobacterium avium-intracellulare complex infection

rifabutin

clarithromycin

ethambutol

rifabutin

clarithromycin

ethambutol


Input: The visual loss in this patient seems to result from phenol neurotoxicity rather than mechanical compression of the intraorbital optic nerve.

result

patient

visual loss

neurotoxicity

phenol

phenol


Input: Polysomnographic and pharmacokinetic findings in levodopa-induced augmentation of restless legs syndrome.

induced

augmentation of restless legs syndrome

levodopa

levodopa


Input: These cases highlight the occurrence of livedo reticularis as an uncommon side-effect of interferon alpha treatment.

side-effect

These cases

livedo reticularis

interferon alpha

interferon alpha


Input: So far, few cases of pulmonary side effects caused by ticlopidine have been reported.

caused

pulmonary side effects

ticlopidine

ticlopidine


Input: Abnormal dexamethasone suppression tests in a rifampicin-treated patient with suspected Cushing's syndrome.

Abnormal

patient with suspected Cushing's syndrome

Abnormal dexamethasone suppression tests

rifampicin

Cushing's syndrome

rifampicin


Input: Gemcitabine therapy has been associated with radiation recall reactions when used in the treatment of carcinoma.

associated

radiation recall reactions

Gemcitabine

Gemcitabine

carcinoma


Input: Increased lash length, thickness, and pigmentation are well-documented side effects of prostaglandin analog glaucoma drops.

are

Increased lash length, thickness, and pigmentation

prostaglandin analog glaucoma drops

drops

prostaglandin analog

glaucoma


Input: Bullous Eruption Associated With Dihydropyridines With Cross Reactivity.

Associated

Bullous Eruption

Dihydropyridines

Dihydropyridines


Input: Ritonavir acted as a CYP3A4 inhibitor, diminishing carbamazepine metabolism and provoking an increase in serum levels and clinical toxicity.

acted

CYP3A4 inhibitor, diminishing carbamazepine metabolism and provoking an increase in serum levels and clinical toxicity

Ritonavir

Ritonavir


Input: Acute generalized exanthematous pustulosis induced by nimesulide.

induced

Acute generalized exanthematous pustulosis

nimesulide

nimesulide


Input: Quinine induced coagulopathy--a near fatal experience.

induced

coagulopathy--a near fatal experience

Quinine

Quinine


Input: A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold.

developed

A 58-year-old man with rheumatoid arthritis

man

lichen planus during

treatment with gold

gold

rheumatoid arthritis


Input: Atenolol-induced pseudolymphoma.

induced

pseudolymphoma

Atenolol

Atenolol


Input: First case report of suspected onset of convulsive seizures due to co-administration of valproic acid and tebipenem.

due

convulsive seizures

co-administration of valproic acid and tebipenem

valproic acid

tebipenem

valproic acid

tebipenem


Input: Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.

related

child with cytochrome P-450 2D6 genetic deficiency

child

cytochrome P-450 2D6 genetic deficiency

death

Fluoxetine

Fluoxetine


Input: Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma.

in

patients

glaucoma

Aplastic anemia and agranulocytosis

methazolamide

methazolamide

glaucoma


Input: We report a 44-year-old woman with t-MDS (refractory anemia with excess blasts) following treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ).

following

a 44-year-old woman

woman

a

t-MDS (refractory anemia with excess blasts)

treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ)

recurrent anaplastic astrocytoma

temozolomide


Input: An infant who developed pancreatitis during meglumine antimoniate treatment for visceral leishmaniasis and who was successfully treated with a combination of allopurinol and ketoconazole is reported.

treated

An infant

infant

pancreatitis

a combination of allopurinol and ketoconazole

allopurinol

ketoconazole

allopurinol

ketoconazole


Input: L-Carnitine supplementation has been recommended to prevent the fatal hepatotoxic effects associated with valproic acid.

associated

hepatotoxic effects

valproic acid

valproic acid


Input: The purpose of this study was to examine the incidence and cause of Clostridium difficile colitis occurring after cisplatin-based combination chemotherapy in ovarian cancer patients.

occurring

ovarian cancer patients

Clostridium difficile colitis

cisplatin-based combination chemotherapy

chemotherapy

cisplatin

ovarian cancer


Input: Cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma.

during

a patient

Cerebral demyelinating disease

adjuvant therapy with levamisole

levamisole

malignant melanoma


Input: Amoxapine-induced cognitive impairment in two patients.

induced

two patients

two

cognitive impairment

Amoxapine

Amoxapine


Input: Granisetron hydrochloride (3 mg on days 1, 8, and 15) and dexamethasone (13.2 mg on day 1 and 6.6 mg on days 2, 3, 8, and 15) were used prior to irinotecan administration in both patients.

used

both patients

Granisetron hydrochloride (3 mg on days 1, 8, and 15) and dexamethasone (13.2 mg on day 1 and 6.6 mg on days 2, 3, 8, and 15)

irinotecan

Granisetron hydrochloride

dexamethasone

3 mg

13.2 mg

6.6 mg

on day 1

on days 1, 8, and 15

on days 2, 3, 8, and 15

dexamethasone

Granisetron hydrochloride


Input: Visceral herpesvirus infections in leukemic patients receiving cytarabine.

in

leukemic patients

Visceral herpesvirus infections

cytarabine

cytarabine.

leukemic


Input: Although a few case reports link metronidazole with the development of pseudomembranous colitis, albendazole has not been associated with the development of this condition.

development

pseudomembranous colitis

metronidazole

metronidazole


Input: CONCLUSION: Oral mucositis is a frequent and potentially severe complication of cancer chemotherapy.

complication

Oral mucositis

cancer chemotherapy

chemotherapy

cancer