Input: To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.

induced

patient

pemphigus

captopril

captopril


Input: Fortunately, a hypersensitivity reaction to one formulation of cyclosporine does not preclude use of a different formulation.

to

hypersensitivity reaction

one formulation of cyclosporine

cyclosporine


Input: She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.

developed

urticarial rash

Enoxaparin

3 weeks following

Enoxaparin


Input: Fatal toxic epidermal necrolysis related to lamotrigine administration.

related to

Fatal toxic epidermal necrolysis

lamotrigine administration

lamotrigine


Input: OBJECTIVE: To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction.

associated

a case

serotonin syndrome (SS)

mirtazapine monotherapy

mirtazapine


Input: CONCLUSION: Therapy with indapamide may induce diabetes in essential hypertension patients.

induce

essential hypertension patients

diabetes

indapamide

indapamide

essential hypertension


Input: Placebo-controlled clinical trials of recombinant human interleukin-11 (rhIL-11, also known as oprelvekin [Neumega]) in patients with nonmyeloid malignancies have demonstrated significant efficacy in preventing postchemotherapy platelet nadirs of < or = 20,000/microL, and reducing the need for platelet transfusions while continuing chemotherapy without dose reductions.

preventing

patients with nonmyeloid malignancies

nonmyeloid malignancies

recombinant human interleukin-11 (rhIL-11, also known as oprelvekin [Neumega])

postchemotherapy platelet nadirs of < or = 20,000/microL

recombinant human interleukin-11


Input: A patient with rheumatoid arthritis developed an acute intrahepatic cholestasis after 100 mg of sodium aurothiomalate.

developed

A patient with rheumatoid arthritis

acute intrahepatic cholestasis

100 mg of sodium aurothiomalate

rheumatoid arthritis

100 mg

sodium aurothiomalate


Input: We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.

caused

colonic ulcer and the sigmoidovesical fistula

calcium polystyrene sulfonate and sorbitol

calcium polystyrene sulfonate

sorbitol

sorbitol

calcium polystyrene sulfonate


Input: Rosiglitazone, a thiazolidinedione antidiabetic medication used in the treatment of Type 2 diabetes mellitus, is predominantly metabolized by the cytochrome P450 (CYP) enzyme CYP2C8.

used

Rosiglitazone

a thiazolidinedione antidiabetic medication

Rosiglitazone

thiazolidinedione antidiabetic medication

Type 2 diabetes mellitus


Input: Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported.

related

Interstitial lung disease (ILD)

therapy with the drug gefitinib

gefitinib


Input: According to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of her acute pancreatitis.

cause

acute pancreatitis

tigecycline

tigecycline


Input: We report a case of severe anemia, which responded well to steroid therapy, in a patient receiving IL-2 plus IFN-alpha for metastatic renal cell carcinoma.

receiving

a patient

severe anemia

IL-2 plus IFN-alpha

metastatic renal cell carcinoma

IFN-alpha

IFN-alpha


Input: The patient's movements resolved following diphenhydramine administration.

resolved

diphenhydramine

diphenhydramine

movements


Input: The spectrum of nitrofurantoin lung injury continues to widen.

widen.

lung injury

nitrofurantoin

nitrofurantoin


Input: We describe a patient with a complex medication regimen who was admitted for rhabdomyolysis and accompanying acute renal failure, along with acute hepatitis, thought to be secondary to a drug interaction between atorvastatin and diltiazem.

secondary

a patient

rhabdomyolysis and accompanying acute renal failure, along with acute hepatitis

atorvastatin

diltiazem

atorvastatin

diltiazem

atorvastatin

diltiazem


Input: The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously.

attributed

eight patients

eight

visual field loss

vigabatrin

vigabatrin


Input: Although the literature on the use of risperidone in elderly patients with dementia consists largely of uncontrolled trials, case reports, and chart reviews, it appears that this agent is effective for managing agitation in this population and does so with a low frequency of extrapyramidal symptoms (EPS).

is

elderly patients with dementia

elderly

use of risperidone

risperidone

dementia


Input: Temozolomide-induced desquamative skin rash in a patient with metastatic melanoma.

induced

a patient with metastatic melanoma

desquamative skin rash

Temozolomide

Temozolomide

metastatic melanoma


Input: The calcium channel blockers are a group of drugs that have recently become available for the treatment of angina.

treatment

calcium channel blockers

angina

calcium channel blockers


Input: We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.

attribute

a young adolescent

young adolescent

benign intracranial hypertension

minocycline

minocycline

acne


Input: A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate.

after

A 10-year-old asthmatic boy

boy

urticarial rash and moderately severe bronchospasm

8 weeks' treatment with disodium cromoglycate

8 weeks'

disodium cromoglycate

asthmatic


Input: Panic anxiety after abrupt discontinuation of mianserin.

after

Panic anxiety

abrupt discontinuation of mianserin

mianserin


Input: This case and other published evidence should alert physicians to the possibility of fatal erlotinib-induced ILD.

induced

This case

ILD

erlotinib

erlotinib


Input: Recent reports suggest that concomitant administration of CYP3A inhibitors with fentanyl may lead to dangerous drug interactions.

lead

drug interactions

concomitant administration of CYP3A inhibitors with fentanyl

CYP3A inhibitors

fentanyl

CYP3A inhibitors

fentanyl


Input: Post-exposure prophylaxis of H1N1 with oseltamivir was safe, effective and well tolerated to prevent H1N1 influenza A virus infection in newly transplanted renal allograft recipient receiving triple immunosuppression without any interaction with tacrolimus level.

prophylaxis

newly transplanted renal allograft recipient

transplanted renal allograft

safe, effective and well tolerated to prevent H1N1 influenza A virus infection

oseltamivir

without any interaction with tacrolimus level

oseltamivir

tacrolimus

tacrolimus

oseltamivir


Input: DISCUSSION: Central nervous system (CNS) toxicity has been described with ifosfamide, with most cases reported in the pediatric population.

described

in the pediatric population

pediatric

Central nervous system (CNS) toxicity

ifosfamide

ifosfamide


Input: Despite the underlying hepatitis C, this case represents renal abnormalities consistent with IFNalpha therapy for CML.

consistent

this case

renal abnormalities

IFNalpha therapy

IFNalpha

CML


Input: CONCLUSION: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.

intoxication

colchicine intoxication

colchicine

colchicine


Input: We have seen a case of terminal malignant melanoma in which clinical manifestations, indicative of anterior spinal artery syndrome, developed following the injection of 0.3 ml of 10% phenol-glycerine into the cervical subarachnoid space at the C4--C5 level for the control of severe right arm pain.

developed

terminal malignant melanoma in which clinical manifestations, indicative of anterior spinal artery syndrome

the injection of 0.3 ml of 10% phenol-glycerine into the cervical subarachnoid space at the C4--C5 level

10% phenol-glycerine

severe right arm pain

injection

cervical subarachnoid space at the C4--C5 level

0.3 ml


Input: Colchicine-induced myopathy in renal failure.

induced

myopathy

Colchicine

Colchicine

renal failure


Input: This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.

toxicity

lung toxicity

bleomycin

bleomycin


Input: DISCUSSION: NMS is a rare but potentially fatal reaction associated with neuroleptic drugs.

associated

NMS

neuroleptic drugs

neuroleptic


Input: Scleroderma in association with the use of bleomycin: a report of 3 cases.

association

3 cases

Scleroderma

bleomycin

bleomycin


Input: Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.

associated

acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome

Linezolid

Linezolid


Input: A 3-year-old boy diagnosed with acute lymphoblastic leukemia received induction chemotherapy.

received

A 3-year-old boy diagnosed with acute lymphoblastic leukemia

boy

induction chemotherapy

acute lymphoblastic leukemia

induction chemotherapy


Input: Interferon and other immunostimulatory medications can lead to an exacerbation of this preexisting low-grade chronic inflammation that is quite similar to interferon-triggered sarcoidosis.

lead

exacerbation of this preexisting low-grade chronic inflammation

Interferon and other immunostimulatory medications

Interferon


Input: Intravenous cytarabine and methotrexate appear to act synergistically to enhance the potential for central nervous system toxicity.

enhance

central nervous system toxicity

Intravenous cytarabine and methotrexate

methotrexate

cytarabine

Intravenous

methotrexate

cytarabine


Input: We suggest adding this side effect to the list of untoward effects of lidocaine and to the differential diagnosis of fixed dilated pupils in neonates treated with lidocaine.

treated

neonates

neonates

side effect

lidocaine

lidocaine


Input: CONCLUSIONS: Topical INF alpha 2-beta is a valid choice for the treatment of CIN in patients for whom surgery is not possible.

a valid choice

patients for whom surgery is not possible

Topical INF alpha 2-beta

CIN

Topical

INF alpha 2-beta


Input: We report 3 patients who developed cutaneous vasculitis which is a rare and serious side-effect during antithyroid drug therapy.

developed

3 patients

cutaneous vasculitis

during antithyroid drug therapy

antithyroid


Input: Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder.

associated

depression and obsessive-compulsive disorder

Prominent eye movements during NREM sleep and REM sleep behavior disorder

fluoxetine treatment

fluoxetine

depression

obsessive-compulsive disorder


Input: Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis.

Allergic reaction

eosinophilic gastroenteritis

gemfibrozil

gemfibrozil


Input: We suggest that sarcoidosis may develop in chronic hepatitis C patients during interferon alpha and/or ribavirin treatment, and diagnostic tests for this adverse effect should be performed during the follow-ups.

develop

chronic hepatitis C patients

sarcoidosis

interferon alpha and/or ribavirin

chronic hepatitis C

interferon alpha

ribavirin


Input: Azole antifungals, prescribed prophylactically to avoid severe infections in immunosuppressed organ transplant recipients, can interact with drug substrates of CYP3A4.

interact

immunosuppressed organ transplant recipients

immunosuppressed organ transplant

Azole antifungals

drug substrates of CYP3A4

severe infections

Azole antifungals

drug substrates of CYP3A4

drug substrates of CYP3A4

Azole antifungals


Input: We present the case of a 5-year-old girl who developed bilateral vocal cord paralysis following preoperative peritonsillar bupivacaine infiltration.

following

a 5-year-old girl

girl

bilateral vocal cord paralysis

preoperative peritonsillar bupivacaine infiltration

bupivacaine

peritonsillar

infiltration


Input: One patient suffered coronary artery vasospasm, attributed to the use of topical 1:1000 epinephrine during surgery.

attributed

One patient

One

coronary artery vasospasm

topical 1:1000 epinephrine during surgery

epinephrine


Input: Trimethoprim-sulfamethoxazole-induced aseptic meningitis.

induced

aseptic meningitis

Trimethoprim-sulfamethoxazole

Trimethoprim-sulfamethoxazole


Input: We describe a patient with metastatic prostate cancer who developed nonoliguric renal failure during treatment with suramin.

during

a patient with metastatic prostate cancer

nonoliguric renal failure

suramin

suramin

metastatic prostate cancer


Input: In conclusion, this case strongly suggests that gliclazide can induce acute icteric liver necro-inflammation which may be misdiagnosed clinically as acute viral hepatitis.

induce

this case

acute icteric liver necro-inflammation

gliclazide

gliclazide


Input: After administration of Oxybutynin concomitantly with an increase in the dose of Dantrolene, she presented the clinical symptoms and laboratory finding of Carbamazepine intoxication.

After

she

she

clinical symptoms and laboratory finding of Carbamazepine intoxication

Oxybutynin concomitantly with an increase in the dose of Dantrolene

Carbamazepine

Carbamazepine

Oxybutynin

Dantrolene

Oxybutynin

Dantrolene


Input: A methotrexate overdosage was shown at 36 h after infusion associated with a severe renal failure.

associated

methotrexate overdosage was shown at 36 h after infusion

severe renal failure

methotrexate

methotrexate


Input: Ceftriaxone-induced fixed drug eruption: first report.

induced

fixed drug eruption

Ceftriaxone

Ceftriaxone


Input: We report the case of a 20-year-old female with polyarteritis nodosa (PAN) who developed bilateral sensorineural hearing loss 25 minutes after receiving 30 mg of intravenous ketoralac.

developed

20-year-old female with polyarteritis nodosa (PAN)

female

bilateral sensorineural hearing loss

30 mg of intravenous ketoralac

polyarteritis nodosa

25 minutes after

30 mg

intravenous

ketoralac


Input: We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia.

after

an 82-year-old man

man

ventricular tachycardia and Torsades de Pointes (TdP)

oral administration of garenoxacin

pneumonia

oral

garenoxacin


Input: Lethargy in a newborn: lithium toxicity or lab error?

toxicity

a newborn

newborn

Lethargy

lithium

lithium


Input: Simultaneous toxicities in a child on multiple anticonvulsants.

on

a child

child

Simultaneous toxicities

multiple anticonvulsants.

anticonvulsants


Input: We report a 71-year male with castration-resistant metastatic prostate cancer who was treated with weekly docetaxel for 12 weeks and developed significant eye irritation and dryness during treatment.

developed

a 71-year male with castration-resistant metastatic prostate cancer

male

significant eye irritation and dryness

weekly docetaxel for 12 weeks

castration-resistant metastatic prostate cancer

docetaxel

weekly

12 weeks


Input: In addition, a 31-year-old man with obsessive-compulsive disorder developed RBD soon after starting fluoxetine therapy, which persisted at PSG study 19 months after fluoxetine discontinuation.

developed

a 31-year-old man with obsessive-compulsive disorder

man

RBD

which persisted at PSG study 19 months after fluoxetine discontinuation

starting fluoxetine therapy

fluoxetine

soon after starting

obsessive-compulsive disorder


Input: Propafenone associated severe central nervous system and cardiovascular toxicity due to mirtazapine: a case of severe drug interaction.

due to

central nervous system and cardiovascular toxicity

Propafenone

mirtazapine

mirtazapine

Propafenone

Propafenone

mirtazapine


Input: Neurotoxicity of intrathecal administration of amphotericin B.

of

Neurotoxicity

intrathecal administration of amphotericin B.

amphotericin B.

intrathecal


Input: Parenteral pyridoxine, the specific antidote for INH-induced refractory seizures, should be readily available in every emergency department in the areas similarly experiencing increasing trends of TB.

induced

refractory seizures

INH

INH


Input: DISCUSSION: Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis, including lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor.

associated

Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure

lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor

lovastatin


Input: Thrombocytosis associated with enoxaparin: A very rare cause in newborns.

associated

newborns

newborns

Thrombocytosis

enoxaparin

enoxaparin


Input: The spectrum of renal lesions occurring during antituberculous therapy, particularly in association with rifampin, may be wider than previously suspected.

during

The spectrum of renal lesions occurring

antituberculous therapy, particularly in association with rifampin

rifampin

antituberculous therapy

rifampin

antituberculous therapy


Input: Native arterial thrombosis, though recognized as a severe complication of thrombin injection, has not been well described in the literature.

complication

Native arterial thrombosis

thrombin injection

thrombin

injection


Input: After treatment with levetiracetam, seizures recurred and intravenous loading with valproic acid was administered, but resulted in a rapid increase in international normalized ratio (INR) to 7.6.

recurred

seizures

levetiracetam

levetiracetam


Input: Acute hepatitis with prolonged cholestasis and disappearance of interlobular bile ducts following tibolone and Hypericum perforatum (St. John's wort).

following

Acute hepatitis with prolonged cholestasis and disappearance of interlobular bile ducts

tibolone and Hypericum perforatum (St. John's wort)

tibolone

Hypericum perforatum


Input: METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.

due to

Five cases

Five

contact dermatitis

budesonide

budesonide


Input: This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.

related

calcium phosphate nephrolithiasis.

acetazolamide

acetazolamide


Input: Aripiprazole was subsequently discontinued secondary to its lack of efficacy for OCD and the development of a movement disorder.

development

a movement disorder

Aripiprazole

OCD

Aripiprazole


Input: Gigantomastia induced by bucillamine.

induced

Gigantomastia

bucillamine

bucillamine


Input: Hypersensitivity to carboplatin has been reported in up to 44% of patients receiving this antineoplastic agent, usually occurring after several courses of treatment.

to

44% of patients

Hypersensitivity

carboplatin

after several courses of treatment

carboplatin


Input: CONCLUSIONS: In our reported case, a local hyperproduction of TNF-alpha from macrophages that was induced by the injected insulin could explain the dedifferentiation of the adipocytes of the subcutaneous tissue and the reversion that was induced by the local injection of dexamethasone.

induced

reported case

local hyperproduction of TNF-alpha from macrophages

dedifferentiation of the adipocytes of the subcutaneous tissue

injected insulin

injected

insulin


Input: Both venlafaxine and trimipramine have been associated with seizures, mainly after overdose.

associated

seizures

overdose

venlafaxine and trimipramine

venlafaxine

trimipramine

overdose


Input: Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.

experienced

five

five

fever, infectious complications, gastrointestinal tract symptoms and severe myalgias

chemotherapy

cytosine arabinoside (ARA-C)

cytosine arabinoside

three-month


Input: Infliximab-induced lupus in Crohn's disease: a case report.

induced

a case

lupus

Infliximab

Infliximab


Input: The infection tended to subside with the AMPH administration.

subside

infection tended

AMPH administration

AMPH


Input: CONTEXT: Acute drug induced hepatitis has not been commonly associated with epidermal growth factor receptor (EGFR) inhibitors.

associated

Acute drug induced hepatitis

epidermal growth factor receptor (EGFR) inhibitors

epidermal growth factor receptor

inhibitors


Input: We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib.

received

a patient with advanced non-small cell lung cancer

pulmonary toxicity

erlotinib

advanced non-small cell lung cancer

erlotinib


Input: We describe a patient with idiopathic RLS who developed augmentation after 8 months of levodopa treatment.

developed

a patient with idiopathic RLS

augmentation

after 8 months of levodopa treatment

idiopathic RLS

8 months

levodopa


Input: This communication describes a patient who developed Schneiderian first-rank symptoms in the course of treatment with fluvoxamine.

developed

a patient

Schneiderian first-rank symptoms

fluvoxamine

fluvoxamine


Input: In addition to the recognized arrhythmic complications, the authors emphasize myocardial necrosis as a possible further manifestation of amsacrine-related cardiotoxicity.

related

myocardial necrosis

cardiotoxicity

amsacrine

amsacrine


Input: The authors caution that treatment with alprazolam may be complicated by the induction of mania.

induction of

mania

treatment with alprazolam

alprazolam


Input: The use of rituximab has been uncommonly associated with delayed pulmonary toxicity.

associated

delayed pulmonary toxicity

rituximab

rituximab


Input: We believe that the acute renal failure in our patient was associated with anastrozole.

associated

patient

acute renal failure

anastrozole

anastrozole


Input: On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.

developed

edema

in both labia

On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone

the fifth day

magnesium sulfate

nifedipine

terbutaline

betamethasone

magnesium sulfate

nifedipine

terbutaline

betamethasone


Input: Two patients with extrinsic asthma and coexistent insulin-dependent diabetes mellitus sustained an anaphylactoid reaction after the intravenous administration of 50% solution of dextrose.

after

Two patients with extrinsic asthma and coexistent insulin-dependent diabetes mellitus

Two

extrinsic asthma

insulin-dependent diabetes mellitus

anaphylactoid reaction

intravenous administration of 50% solution of dextrose

intravenous

dextrose


Input: Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity.

after

Cardiac arrest

esmolol

esmolol


Input: We suggest that nicotinic acid was the cause of his liver disease, that this case is of particular note because of the rather short period of therapy before the onset of liver injury and the severity of the hepatic failure, and that the probable increased use of nicotinic acid for serum cholesterol control makes it especially important for physicians and their patients to be alert to the signs of hepatotoxicity.

cause

liver disease

nicotinic acid

nicotinic acid


Input: METHODS: Two patients with exudative age-related macular degeneration were treated sequentially with an intravitreal injection of bevacizumab and developed signs of severe but painless infectious endophthalmitis 2 days later.

developed

Two patients

Two

infectious endophthalmitis

intravitreal injection of bevacizumab

2 days later

exudative age-related macular degeneration

intravitreal injection

bevacizumab

2 days later.


Input: Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.

induced

meningitis

Ibuprofen

Ibuprofen


Input: Tardive oculogyric crisis during treatment with clozapine: report of three cases.

with

three cases

three

Tardive oculogyric crisis

clozapine

clozapine


Input: Myasthenia gravis during low-dose IFN-alpha therapy for chronic hepatitis C.

during

Myasthenia gravis

low-dose IFN-alpha therapy

low-dose

IFN-alpha

chronic hepatitis C.


Input: We herein report this rare case of acute onset of nephrotic syndrome during interferon-alpha retreatment.

during

acute onset of nephrotic syndrome

interferon-alpha

interferon-alpha


Input: Para-aminosalicylic acid-induced hypoglycaemia in a patient with diabetic nephropathy.

induced

a patient with diabetic nephropathy

diabetic nephropathy

hypoglycaemia

Para-aminosalicylic acid

Para-aminosalicylic acid


Input: Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine.

following

Ischaemia

selfadministered intra-arterial injection of methylphenidate and diamorphine

methylphenidate

diamorphine

intra-arterial injection

methylphenidate

diamorphine


Input: Mitomycin C-related hemolytic uremic syndrome in cancer patients.

related

cancer patients

hemolytic uremic syndrome

Mitomycin C

Mitomycin C

cancer


Input: The second had acute cystitis and was treated by sulphonamide and the third developed myopia coincident with metronidazole treatment for trichomonas vaginalis.

developed

the third

myopia

metronidazole treatment

metronidazole

trichomonas vaginalis


Input: Acute bilateral phrenic neuropathy following treatment with adalimumab.

following

Acute bilateral phrenic neuropathy

adalimumab

adalimumab


Input: Hypoxemia improved during continuous tolazoline infusion, but gastrointestinal bleeding occurred.

occurred.

gastrointestinal bleeding

Hypoxemia improved during continuous tolazoline infusion

Hypoxemia

tolazoline

infusion


Input: BACKGROUND: NVP is a non-nucleoside reverse transcriptase inhibitor used in the treatment of Human Immunodeficiency Virus (HIV) infection.

used

NVP

Human Immunodeficiency Virus (HIV) infection

NVP


Input: A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.

developed

A 62-year-old Indian with diabetic nephropathy

Indian

miliary tuberculosis

metformin

diabetic nephropathy

metformin


Input: A patient with acute esophageal variceal bleeding developed fatal rhabdomyolysis during treatment with a continuous intravenous infusion of vasopressin.

during

A patient with acute esophageal variceal bleeding

fatal rhabdomyolysis

continuous intravenous infusion of vasopressin

continuous intravenous infusion

vasopressin

acute esophageal variceal bleeding


Input: Preliminary results suggest that the higher concentrations of dextrose induce increased histamine release from blood cells, and that this phenomenon is more marked in diabetic, and particularly diabetic-allergic, individuals.

induce

diabetic, and particularly diabetic-allergic, individuals

diabetic

diabetic-allergic

increased histamine release from blood cells

higher concentrations of dextrose

dextrose

higher concentrations


Input: All patients beginning HMG-CoA reductase inhibitor therapy should be counseled regarding the signs and symptoms of muscle injury; particular attention should be paid to those patients who are taking medications that may interact.

regarding

All patients

the signs and symptoms of muscle injury

HMG-CoA reductase inhibitor

HMG-CoA reductase inhibitor


Input: Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease.

induced

hyperthyroidism

Graves' disease

Interferon-alpha

Interferon-alpha


Input: Acute severe intoxication with carbamazepine is associated with seizures, coma and respiratory depression.

associated

Acute severe intoxication

carbamazepine

carbamazepine


Input: CONCLUSION: We have introduced a case of anaphylaxis by calcitonin that suggest an IgE mediated hypersensitivity reaction.

by

a case

anaphylaxis

calcitonin

calcitonin


Input: PURPOSE: To describe transient structured visual hallucinations in a patient with vascular age-related macular degeneration (AMD), following an intravitreal Avastin-injection.

following

a patient with vascular age-related macular degeneration (AMD)

transient structured visual hallucinations

an intravitreal Avastin-injection

vascular age-related macular degeneration (AMD)

Avastin

intravitreal

injection


Input: Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor.

induced

paralytic ileus

Bortezomib

Bortezomib


Input: Fatal gemcitabine-induced pulmonary toxicity in metastatic   gallbladder adenocarcinoma.

induced

pulmonary toxicity

gemcitabine

metastatic   gallbladder adenocarcinoma

gemcitabine


Input: It is suggested that the fatal stroke may have resulted from arterial spasm caused by ergotamine overdosage and possibly complicated by thrombosis.

caused

stroke

arterial spasm

ergotamine overdosage

ergotamine


Input: During the anti-tuberculous therapy, visual loss can be related to ethambutol toxicity or the tuberculosis infection itself.

related

visual loss

ethambutol

ethambutol

tuberculosis infection


Input: Elevated International Normalized Ratio in a patient concurrently using warfarin and vismodegib.

using

a patient

Elevated International Normalized Ratio

warfarin and vismodegib

warfarin

vismodegib

warfarin

vismodegib


Input: Occurrence of IDDM during interferon therapy for chronic viral hepatitis.

during

IDDM

interferon therapy

interferon

chronic viral hepatitis


Input: Pseudomembranous colitis readily occurs in at least certain population groups receiving trimethoprim-sulfamethoxazole.

occurs

certain population groups

Pseudomembranous colitis

trimethoprim-sulfamethoxazole

trimethoprim

sulfamethoxazole

sulfamethoxazole

trimethoprim


Input: RESULTS: Budesonide use can cause contact dermatitis.

cause

contact dermatitis

Budesonide

Budesonide


Input: Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone.

when

most patients

most

Hypertension

after transplantation

immunosuppression is based on cyclosporine and prednisone

cyclosporine

prednisone


Input: It was concluded that potassium loss occurred by a non-renal (intestinal) route in phosphate-induced hypokalemia.

induced

potassium loss

hypokalemia

phosphate

phosphate


Input: We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.

developed

three patients with hepatitis C

three

Graves' disease

two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease

IFN-alpha and ribavirin

hepatitis C

IFN-alpha

ribavirin


Input: Hepatotoxicity associated with choline magnesium trisalicylate: case report and review of salicylate-induced hepatotoxicity.

associated

case

Hepatotoxicity

choline magnesium trisalicylate

choline magnesium trisalicylate


Input: CONCLUSIONS: The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy.

development

The 3 cases

women with epilepsy

women

reproductive endocrine disorders

after the initiation of valproate therapy

valproate

epilepsy


Input: A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate.

after

A 43-year-old white man

white

man

shallow erosion of a psoriatic plaque

chronic administration of methotrexate

methotrexate

psoriatic plaque

chronic


Input: CONCLUSIONS: SD-OCT and AO detected abnormalities that correlate topographically with visual field loss from hydroxychloroquine toxicity as demonstrated by HVF 10-2 and may be useful in the detection of subclinical abnormalities that precede symptoms or objective visual field loss.

from

visual field loss

hydroxychloroquine

hydroxychloroquine


Input: Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis.

induced

a patient with rheumatoid arthritis

toxic epidermal necrolysis

Leflunomide

rheumatoid arthritis

Leflunomide


Input: Delayed bowel injury is an infrequently observed complication of chromic phosphate administration.

complication

Delayed bowel injury

chromic phosphate administration

chromic phosphate


Input: Therefore, amantadine was permanently discontinued and the cornea cleared again.

was

cornea cleared

amantadine

amantadine


Input: CONCLUSION: We believe that risperidone is not a substitute for clozapine in treating psychosis in parkinsonian patients and should be used with caution.

treating

parkinsonian patients

parkinsonian

risperidone

psychosis

risperidone


Input: Spontaneous splenic infarction associated with sumatriptan use.

associated

Spontaneous splenic infarction

sumatriptan

sumatriptan


Input: DISCUSSION: Anaphylactoid reactions have been described previously with cisplatin administration.

with

Anaphylactoid reactions

cisplatin

cisplatin


Input: The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.

developed

a man

man

widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer

zonisamide for epilepsy

epilepsy

zonisamide


Input: The toxicity of cadmium, zinc, and cadmium/zinc mixtures at concentrations ranging from 10000 to 10 microg/l was investigated.

of

toxicity

cadmium, zinc, and cadmium/zinc mixtures at concentrations ranging from 10000 to 10 microg/l

from 10000 to 10 microg/l

cadmium

zinc

cadmium

zinc

cadmium

zinc


Input: We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.

developed

an elderly woman with a pre-existing history of ischaemic heart disease

elderly

woman

ischaemic heart disease

acute myocardial ischaemia within the first week of treatment

venlafaxine

venlafaxine

within the first week


Input: Here, we describe a case of Vogt-Koyanagi-Harada disease occurring 4 months after the start of interferon alpha treatment, probably induced by the immunomodulatory effects of interferon.

occurring

a case

Vogt-Koyanagi-Harada disease

4 months after the start of interferon alpha

4 months

interferon alpha


Input: Capecitabine-induced headache responding to diltiazem.

induced

headache

Capecitabine

Capecitabine


Input: Serotonin syndrome after concomitant treatment with linezolid and meperidine.

after

Serotonin syndrome

concomitant treatment with linezolid and meperidine

linezolid

meperidine

linezolid

meperidine


Input: We report on a child with fatal valproate-related hepatotoxic effects despite this supplementation.

related

a child

child

hepatotoxic effects

valproate

valproate


Input: Acute isoniazid neurotoxicity in an urban hospital.

in

Acute

neurotoxicity

isoniazid

isoniazid


Input: In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine.

inhibition

a patient with systemic sclerosis

vitro inhibition of hematopoiesis

D-penicillamine

systemic sclerosis

D-penicillamine


Input: Rhabdomyolysis has been reported in patients receiving hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors when coadministered with agents that may inhibit their metabolism.

receiving

patients

Rhabdomyolysis

hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors when coadministered with agents that may inhibit their metabolism

hydroxymethylglutaryl coenzyme A

agents that may inhibit their metabolism

hydroxymethylglutaryl coenzyme A

agents that may inhibit their metabolism


Input: A 55-year-old woman presented an episode of acute urticaria and labial angioedema 60 minutes after ingesting 500 mg of cloxacillin for a skin abscess.

presented

A 55-year-old woman

a skin abscess

woman

acute urticaria and labial angioedema

ingesting 500 mg of cloxacillin

60 minutes

ingesting

500 mg

cloxacillin

skin abscess


Input: Acne provoked by gold seems not to have been described elsewhere.

provoked

Acne

gold

gold


Input: Taxanes are widely used chemotherapeutic agents with the potential to induce pulmonary injury through a variety of mechanisms.

induce

pulmonary injury

Taxanes

Taxanes


Input: PURPOSE: To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.

following

two cases

two

acute endophthalmitis

intravitreal bevacizumab injection

intravitreal

injection

bevacizumab


Input: This is a case report of subtle, mild hypothermia in a 54-year old female patient receiving risperidone for schizophrenia.

receiving

a 54-year old female patient

54-year old

female

mild hypothermia

risperidone

risperidone

schizophrenia


Input: Mycophenolate mofetil-induced neutropenia in liver transplantation.

induced

neutropenia in liver transplantation

Mycophenolate mofetil

Mycophenolate mofetil


Input: Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period, while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred.

development

new brain lesions

six weeks and 11 months of penicillamine therapy

six weeks and 11 months

penicillamine


Input: According to the literature, chlorambucil central nervous toxicity is found almost exclusively in childhood nephrotic syndrome.

found

childhood nephrotic syndrome

childhood

nephrotic syndrome

central nervous toxicity

chlorambucil

chlorambucil


Input: Administration of lamotrigine, especially in combination with valproic acid, may lead to the development of TEN.

development

TEN

Administration of lamotrigine

with valproic acid

valproic acid

lamotrigine

valproic acid

lamotrigine


Input: Docetaxel induced Meibomian duct inflammation and blockage is the likely cause of this presentation in a patient with no history of eyelid masses in the past.

induced

a patient with no history of eyelid masses in the past

Meibomian duct inflammation and blockage

Docetaxel

Docetaxel


Input: We describe a unique case of disseminated cryptococcosis presenting as colitis that mimicked an exacerbation of Crohn's disease in a TNF-alpha inhibitor recipient.

in

recipient

an exacerbation of Crohn's disease

a TNF-alpha inhibitor

TNF-alpha inhibitor


Input: Rhabdomyolysis associated with the use of intravenous vasopressin.

associated

Rhabdomyolysis

intravenous vasopressin

vasopressin


Input: Administration of intravenous nitroglycerin in a patient with idiopathic pulmonary hypertension resulted in an increase in pulmonary artery pressure associated with a decrease in blood flow that is best explained by an increase in pulmonary vascular resistance.

Administration

a patient with idiopathic pulmonary hypertension

increase in pulmonary artery pressure associated with a decrease in blood flow that is best explained by an increase in pulmonary vascular resistance

intravenous nitroglycerin

idiopathic pulmonary hypertension

intravenous

nitroglycerin


Input: The increased libido disappeared after fluvoxamine was discontinued.

after

increased libido

fluvoxamine

fluvoxamine


Input: Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.

interfere

tacrolimus metabolism

tacrolimus

Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily

tacrolimus

nefazodone

nefazodone

tacrolimus


Input: CONCLUSIONS: We conclude that a high dose combined with a short infusion time increases the risk of anaphylactoid reactions with the administration of intraperitoneal cisplatin.

with

anaphylactoid reactions

a high dose combined with a short infusion time

administration of intraperitoneal cisplatin

high dose

cisplatin

intraperitoneal


Input: Human insulin-induced lipoatrophy.

induced

lipoatrophy

Human insulin

Human insulin


Input: Severe hepatotoxicity from phenobarbital occurred in an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis.

from

an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis.

infant

boy

Severe hepatotoxicity

phenobarbital

phenobarbital

chronic bilateral subdural hematomas

sepsis


Input: Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.

after

Cholestatic liver disease with ductopenia (vanishing bile duct syndrome)

clindamycin and trimethoprim-sulfamethoxazole

clindamycin

trimethoprim

sulfamethoxazole

clindamycin

sulfamethoxazole

trimethoprim


Input: The authors suggest that in the absence of any proven benefit of itraconazole prophylaxis, and given the interaction of this drug with vincristine leading to severe and even potentially fatal toxicities, the combination use of these drugs should be avoided.

leading

severe and even potentially fatal toxicities

itraconazole

vincristine

itraconazole

vincristine

itraconazole

vincristine


Input: The determinant role of individual pharmacogenetic profile in the occurrence of tacrolimus nephrotoxicity is presented and discussed.

occurrence

tacrolimus nephrotoxicity

tacrolimus

tacrolimus


Input: These findings suggest that bicytopenia in this patient was caused by D-Pen and may be due to different sensitivities in the hematopoietic lineage.

caused

patient

bicytopenia

D-Pen

D-Pen


Input: We strongly suspect that this lethal anuria was mainly due to ifosfamide, occurring in a patient having received previous cisplatin chemotherapy and with poor kidney perfusion due to transient hypotension.

occurring

a patient having received previous cisplatin chemotherapy and with poor kidney perfusion due to transient hypotension

poor kidney perfusion

lethal anuria

ifosfamide

having received previous cisplatin chemotherapy

ifosfamide

cisplatin

ifosfamide

cisplatin


Input: Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.

administered

thiazide diuretics

polyuria

nephrogenic diabetes insipidus

thiazide diuretics


Input: We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren.

associated

acute renal failure with hyperkalemia

renin inhibitor aliskiren

aliskiren


Input: The authors describe a patient with hemiparesis who developed the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) while being treated with lithium for a manic episode.

developed

a patient with hemiparesis

hemiparesis

irreversible lithium-effectuated neurotoxicity (SILENT)

lithium for a manic episode

lithium

manic episode


Input: over the past 3 years there have been several reports of uveitis associated with rifabutin therapy.

associated

uveitis

rifabutin therapy

rifabutin


Input: Propylthiouracil-induced cutaneous vasculitis.

induced

cutaneous vasculitis

Propylthiouracil

Propylthiouracil


Input: It has been reported that fluoroquinolone antimicrobials prolong the corrected QT interval but rarely cause torsade de pointes.

prolong

corrected QT interval but rarely cause torsade de pointes

fluoroquinolone antimicrobials

fluoroquinolone


Input: Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy.

induced

a patient with mucositis

mucositis

hyperkalemia

Succinylcholine

Succinylcholine


Input: To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.

associated

the first case

gastric LPD

MTX

MTX

MTX


Input: We describe a patient with acute myeloblastic leukemia (AML) who developed nephrotic syndrome after receiving several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF).

after

a patient with acute myeloblastic leukemia (AML)

nephrotic syndrome

several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF)

acute myeloblastic leukemia

macrophage-colony-stimulating factor

chemotherapy


Input: Actinomycin D associated hepatic veno-occlusive disease--a report of 2 cases.

associated

hepatic veno-occlusive disease

Actinomycin D

Actinomycin D


Input: Our patient developed both nephrogenic diabetes insipidus and renal tubular acidosis with a temporal pattern that demonstrated a link between foscarnet therapy and these abnormalities.

developed

patient

nephrogenic diabetes insipidus and renal tubular acidosis

foscarnet

foscarnet


Input: We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne.

occurring

a case

acne fulminans

13-cis-retinoic acid

13-cis-retinoic acid

cystic acne


Input: Verapamil is widely used for the termination of paroxysmal supraventricular tachycardia (PSVT) with little proarrhythmic effect.

with

proarrhythmic effect

Verapamil

Verapamil

paroxysmal supraventricular tachycardia


Input: Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.

induced

hypersensitivity syndrome

zonisamide

zonisamide


Input: Our findings suggest that hyperkalemia can develop with the use of low-dose heparin, within seven days of initiating heparin therapy, and that patients with diabetes mellitus or chronic renal insufficiency are especially predisposed to this complication.

develop

patients with diabetes mellitus or chronic renal insufficiency

diabetes mellitus

chronic renal insufficiency

hyperkalemia

low-dose heparin, within seven days of initiating heparin therapy

low-dose

heparin

within seven days


Input: We report a case of Zidovudine induced anaemia and bone marrow aplasia in a patient infected with HIV.

induced

a patient infected with HIV

anaemia and bone marrow aplasia

Zidovudine

Zidovudine

HIV


Input: We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy.

during

adult Crohn's disease patient

adult

a parvovirus B19 infection and leukopenia

long-term AZA therapy

Crohn's disease

AZA

long-term


Input: Pathogenesis of methotrexate-induced papular eruption in psoriasis may involve immune mechanisms other than those of methotrexate-induced cutaneous vasculitis in collagen vascular disease.

induced

papular eruption in psoriasis

cutaneous vasculitis in collagen vascular disease

methotrexate

methotrexate


Input: CASES: Two postmenopausal women treated with tamoxifen and progestational agents for breast carcinoma developed uterine enlargement and intermittent spotting.

developed

Two postmenopausal women

Two

women

uterine enlargement and intermittent spotting

tamoxifen and progestational

tamoxifen

breast carcinoma


Input: Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma.

after

Tumor lysis syndrome

transcatheter arterial infusion of cisplatin and embolization

liver metastases of melanoma

transcatheter arterial infusion

cisplatin


Input: Oxcarbazepine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).

induced

Eosinophilia and Systemic Symptoms (DRESS)

Oxcarbazepine

Oxcarbazepine


Input: Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.

in

patients with Wilson's disease

Worsening of neurologic syndrome

penicillamine therapy

penicillamine

Wilson's disease


Input: Patient A reported right leg weakness (foot drop) during week 4 of CAP-XRT (1600 mg/m2).

during

Patient A

right leg weakness

week 4 of CAP-XRT (1600 mg/m2)

week 4

CAP-XRT

1600 mg/m2


Input: A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.

developed

A child

child

hypersensitivity drug reaction

which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis

phenobarbital

phenobarbital


Input: Detection of activated eosinophils in nasal polyps of an aspirin-induced asthma patient.

induced

asthma

aspirin

aspirin


Input: We recommend that clinicians monitor patients for signs and symptoms of pancreatitis, including abdominal pain, during treatment with tigecycline.

treatment

pancreatitis, including abdominal pain

tigecycline

tigecycline


Input: We describe a patient who experienced a lichenoid eruption after the initiation of salsalate for relief of arthritic pain.

after

a patient

lichenoid eruption

the initiation of salsalate

initiation

salsalate

arthritic pain


Input: Concomitant administration of lithium with olanzapine may place patients at risk for NMS.

administration

patients

NMS

lithium

olanzapine

lithium

olanzapine

lithium

olanzapine


Input: We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).

presented

an 87-year-old white woman with myasthenia gravis

white

woman

nausea, shortness of breath, azotemia, and hyperkalemia

intravenous immunoglobulin

immunoglobulin

myasthenia gravis

intravenous


Input: Linezolid should be discontinued immediately in patients experiencing these adverse effects.

discontinued

patients

adverse effects

Linezolid

Linezolid


Input: PURPOSE: Symptomatic visual field constriction thought to be associated with vigabatrin has been reported.

associated

Symptomatic visual field constriction

vigabatrin

vigabatrin


Input: Clinically significant adverse events from a drug interaction between quetiapine and atazanavir-ritonavir in two patients.

adverse events

two patients

two

Clinically significant

interaction between quetiapine and atazanavir-ritonavir

quetiapine

atazanavir-ritonavir

quetiapine

atazanavir-ritonavir


Input: OBJECTIVE: To report two cases of fixed drug eruption induced by methylphenidate.

induced

two cases

two

fixed drug eruption

methylphenidate

methylphenidate


Input: Linezolid is an oxazolidinone antibacterial agent indicated for serious gram-positive infections.

indicated

Linezolid

serious gram-positive infections

Linezolid


Input: A search of the United States Food and Drug Administration's Adverse Event Reporting System identified nine cases of oxcarbazepine-associated angioedema in pediatric patients aged 16 years and younger.

associated

pediatric patients aged 16 years and younger

16 years and younger

pediatric

angioedema

oxcarbazepine

oxcarbazepine


Input: Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.

abnormal

patients

abnormal liver function

receiving high doses of cyproterone acetate

cyproterone acetate

high doses


Input: In six cases CT scans did not return to their original state after ACTH therapy.

after

six cases

six

CT scans did not return to their original state

ACTH

ACTH


Input: This report describes a probable case of infliximab-induced membranous nephropathy.

induced

membranous nephropathy

infliximab

infliximab


Input: Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis.

during

Thrombotic thrombocytopenic purpura

penicillamine

rheumatoid arthritis

penicillamine


Input: OBJECTIVE: The purpose of this study was to determine whether desensitization to NPH insulin, as well as standard insulin desensitization, could control allergic symptoms in a patient allergic to both NPH and regular insulin.

control

a patient allergic to both NPH and regular insulin

desensitization to NPH insulin, as well as standard insulin desensitization

allergic symptoms in a patient allergic to both NPH and regular insulin

NPH insulin

standard insulin

desensitization

desensitization

NPH insulin

standard insulin


Input: Fulminant hepatic failure developed in a 24-year-old black woman who had been treated with propylthiouracil and propranolol for hyperthyroidism.

developed

a 24-year-old black woman

black

woman

Fulminant hepatic failure

propylthiouracil and propranolol

propylthiouracil

propranolol

hyperthyroidism

propranolol

propylthiouracil


Input: However, as the use of hepatitis B vaccination is growing, adverse side effects, including mental nerve neuropathy, should be observed with an increased frequency.

observed

mental nerve neuropathy

hepatitis B vaccination

hepatitis B vaccination


Input: Acute coronary events following cisplatin-based chemotherapy.

following

Acute coronary events

cisplatin-based chemotherapy

cisplatin

chemotherapy


Input: Capecitabine (CAP) is a pro-drug of 5-FU and peripheral neuropathy associated with CAP has not been reported.

associated

peripheral neuropathy

CAP


Input: PURPOSE: To report a case of angiographically documented cystoid macula edema occurring after switching a pseudophakic patient from latanoprost to bimatoprost.

switching

a pseudophakic patient

case of angiographically documented cystoid macula edema

from latanoprost to bimatoprost.

latanoprost

bimatoprost

pseudophakic


Input: The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.

identical

maculopathy

chloroquine and hydroxychloroquine

chloroquine

hydroxychloroquine


Input: CONCLUSION: A woman receiving enoxaparin every 12 hours developed signs and symptoms of hepatotoxicity after the second dose.

developed

A woman

woman

signs and symptoms of hepatotoxicity

enoxaparin every 12 hours

after the second dose

enoxaparin

every 12 hours

the second dose.


Input: A case of liver damage following treatment with Danazol for fibrocystic breast disease is reported.

following

liver damage

Danazol

Danazol

fibrocystic breast disease


Input: Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature.

induced

a case

hypophosphatemic osteomalacia

Antacid and sucralfate

sucralfate

Antacid


Input: We report a case of senna-induced cholestatic hepatitis which was not diagnosed at presentation.

induced

a case

cholestatic hepatitis

senna

senna


Input: Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure.

responsible

Five patients

Five

acute renal failure

gentamicin sulfate

gentamicin sulfate


Input: However, in order to avoid neuropathic side effects, patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug.

under

patients

neuropathic side effects

thalidomide therapy

thalidomide


Input: Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.

demonstrated

marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia

levodopa

levodopa


Input: Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.

developed

four patients with spinal cord injury

four

Antibiotic-associated colitis (pseudomembranous colitis)

oral trimethoprim-sulfamethoxazole

sulfamethoxazole

trimethoprim

oral

spinal cord injury

trimethoprim

sulfamethoxazole


Input: We report the case of a 27-year-old Indian woman who developed maculopapular rash and angioedema secondary to carbamazepine administration.

developed

a 27-year-old Indian woman

Indian

woman

maculopapular rash and angioedema

carbamazepine administration

carbamazepine

administration


Input: We reviewed the literature in an attempt to characterize the pattern and predictors of TMP/SMX-induced aseptic meningitis.

induced

aseptic meningitis

TMP/SMX

TMP

SMX

SMX

TMP


Input: Mean time between initiation of gemcitabine therapy and onset of HUS was 7.4 +/- 3.5 months, or 21.9 +/- 10.9 doses of gemcitabine.

onset

HUS

7.4 +/- 3.5 months, or 21.9 +/- 10.9 doses of gemcitabine

gemcitabine

7.4 +/- 3.5 months

21.9 +/- 10.9 doses


Input: Aluminum intoxication, along with other factors, was considered to be the cause of TC development.

cause

TC development

Aluminum intoxication

Aluminum


Input: Agranulocytosis during clozapine therapy.

during

Agranulocytosis

clozapine therapy

clozapine


Input: It was highly suspected that finasteride was associated with the anterior subcapsular opacity on the lens, and the patient therefore discontinued use of finasteride.

associated

the patient

anterior subcapsular opacity on the lens

finasteride

finasteride


Input: Life-threatening cranial dystonia following trihexyphenidyl withdrawal.

following

cranial dystonia

trihexyphenidyl withdrawal

trihexyphenidyl


Input: The risk of cardiac decompensation in infants with supraventricular tachycardia and congestive cardiac failure should be kept in mind prior to administration of verapamil.

risk

infants with supraventricular tachycardia and congestive cardiac failure

congestive cardiac failure

infants

cardiac decompensation

verapamil

verapamil

supraventricular tachycardia


Input: We describe serotonin syndrome after concomitant use of linezolid and meperidine in a 27-year-old man with acute leukemia.

after

a 27-year-old man with acute leukemia

acute leukemia

man

serotonin syndrome

concomitant use of linezolid and meperidine

linezolid

meperidine

linezolid

meperidine


Input: Recent studies have shown that under experimental conditions ferrous sulfate may reduce the gastrointestinal absorption of orally administered levothyroxine sodium in patients with primary hypothyroidism.

reduce

patients with primary hypothyroidism

primary hypothyroidism

reduce the gastrointestinal absorption of orally administered levothyroxine sodium

ferrous sulfate

orally administered levothyroxine sodium

ferrous sulfate

levothyroxine sodium

orally

ferrous sulfate

levothyroxine sodium


Input: We report here a case of cardiovascular and neurological depression induced by oxymetalzoline in a toddler.

induced

a toddler

toddler

cardiovascular and neurological depression

oxymetalzoline

oxymetalzoline


Input: The association between heparin and priapism is often recognized; abnormal platelet aggregation could play a role in the pathogenesis of this side effect.

association

priapism

heparin

heparin


Input: Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary.

following

Posterior leukoencephalopathy

cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary

germ cell tumor of the ovary

cisplatin

bleomycin

vinblastine

vinblastine

bleomycin

cisplatin


Input: OBJECTIVE: To report a case of cutaneous and hematologic toxicity in a patient treated with IL-2.

case

a patient

cutaneous and hematologic toxicity


Input: Flecainide is a rare cause of hypersensitivity pneumonitis, and few cases have been reported.

cause

hypersensitivity pneumonitis

Flecainide

Flecainide


Input: The patient developed grade 3 capecitabine-induced headache.

induced

headache

capecitabine

capecitabine


Input: We report a case of biopsy-proven acute tubulointerstitial nephritis associated with a second course of flurbiprofen, a nonsteroidal anti-inflammatory drug of the propionic acid class.

associated

biopsy-proven acute tubulointerstitial nephritis

a second course of flurbiprofen

flurbiprofen

second course


Input: Although an association between exposure to bleomycin and the development of scleroderma has been suspected, few cases are reported.

development

few cases

scleroderma

bleomycin

bleomycin


Input: A 74-year-old man received oral administration of pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert paroxysmal atrial fibrillation to sinus rhythm and developed loss of consciousness two days later.

developed

A 74-year-old man

man

loss of consciousness

oral administration of pilsicainide

two days later

oral

pilsicainide

paroxysmal atrial fibrillation

two days later


Input: Aggressive endometrial carcinoma in a breast cancer patient treated with tamoxifen with normal transvaginal ultrasonography.

treated

breast cancer patient

with normal transvaginal ultrasonography

Aggressive endometrial carcinoma

tamoxifen

breast cancer

tamoxifen


Input: Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.

include

the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints

dapsone

dapsone


Input: The association of venlafaxine treatment with ischaemic events could be explained by its unique pharmacological and haemodynamic properties.

association

ischaemic events

venlafaxine treatment

venlafaxine


Input: This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure.

response

ductal closure

indomethacin exposure

indomethacin

exposure


Input: This pattern is suggestive of renal toxicity due to tobramycin.

due to

renal toxicity

tobramycin

tobramycin


Input: OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy.

induced

severe human

lipoatrophy

insulin

insulin


Input: This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer.

related

a unique autopsy case

hepatocellular carcinoma

diethylstilbestrol (DES)

prostatic cancer

diethylstilbestrol


Input: Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.

for

Argatroban

hepato-renal failure

Argatroban


Input: Falling backward in two elderly patients taking bupropion.

taking

two elderly patients

two

elderly

Falling backward

bupropion

bupropion


Input: METHODS: Three patients with apparent itraconazole-induced liver injury were studied.

induced

Three patients

Three

liver injury

itraconazole

itraconazole


Input: Six patients developed peripheral neuropathy and five patients bone marrow depression, blood transfusions were given to three patients and in all five patients bone marrow function normalized after cessation of linezolid.

normalized

all five patients

five

cessation of linezolid

bone marrow depression

linezolid


Input: To our knowledge, four cases of interstitial pneumonitis associated with fludarabine have been reported in medical literature.

associated

interstitial pneumonitis

fludarabine

fludarabine


Input: Normalization of generalized retinal function and progression of maculopathy after cessation of therapy in a case of severe hydroxychloroquine retinopathy with 19 years follow-up.

after

a case of severe hydroxychloroquine retinopathy

Normalization of generalized retinal function and progression of maculopathy

cessation of therapy

hydroxychloroquine

hydroxychloroquine

hydroxychloroquine retinopathy

19 years


Input: Interferon-induced psychosis as a "psychiatric contraindication" to hepatitis C treatment: a review and case-based discussion.

induced

psychosis

Interferon

Interferon

hepatitis C


Input: Prolongation of the QT interval and ventricular tachyarrhymias have been described in patients on amiodarone therapy.

described

patients

Prolongation of the QT interval and ventricular tachyarrhymias

amiodarone therapy

amiodarone


Input: Aripiprazole, 5 mg daily, was initiated in November 2004 as an augmentation strategy for the diagnosis of OCD.

augmentation

Aripiprazole

5 mg daily

OCD

Aripiprazole

5 mg

daily


Input: Serious adverse events experienced by patients with chronic heart failure taking spironolactone.

experienced

patients with chronic heart failure

chronic heart failure

Serious adverse events

spironolactone

spironolactone


Input: Review of the literature relating to methicillin-induced nephropathy suggests a hypersensitivity origin for this disorder, but immunologic and ultrastructural investigation to date has failed to elucidate pathogenesis.

induced

nephropathy

hypersensitivity

methicillin

methicillin


Input: ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.

associated

ARDS

the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3

infliximab

gemtuzumab

ozogamicin


Input: CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual "shining," glare, color vision anomalies, and gradually decreased vision.

after initiation

a 76-year-old man

man

symptoms of visual "shining," glare, color vision anomalies, and gradually decreased vision

amiodarone HCl

amiodarone HCl

(200 mg

day


Input: An insulin-dependent diabetic patient with nephropathy developed severe acidosis after treatment with acetazolamide for glaucoma.

developed

An insulin-dependent diabetic patient with nephropathy

diabetic

nephropathy

severe acidosis

acetazolamide for glaucoma

glaucoma

acetazolamide


Input: Severe hypo-alpha-lipoproteinemia during treatment with rosiglitazone.

during

hypo-alpha-lipoproteinemia

rosiglitazone

rosiglitazone


Input: Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.

associated

Peripheral neuropathy and cerebellar syndrome

amiodarone

amiodarone


Input: CONCLUSIONS: We report this case of the concomitant appearance of multiple skin cancers and nail changes associated with hydroxyurea use.

associated

case

multiple skin cancers and nail changes

hydroxyurea

hydroxyurea


Input: As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen-specific cellular immunity.

development

a strong delayed-type hypersensitivity response

tuberculin

tuberculin


Input: Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.

related

increased vincristine neurotoxicity

Itraconazole

Itraconazole

vincristine

Itraconazole

vincristine


Input: A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.

episode

A 62-year-old Caucasian man with atrial fibrillation

Caucasian

man

hematochezia

warfarin

atrial fibrillation

warfarin


Input: Severe anaemia related to oseltamivir during treatment of chronic hepatitis C: a new drug interaction?

related

anaemia

oseltamivir during treatment of chronic hepatitis C

oseltamivir

chronic hepatitis C


Input: BACKGROUND: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.

induced

psychotic patients

agranulocytosis or granulocytopenia

clozapine

clozapine

psychotic


Input: Cystoid macular edema in a low-risk patient after switching from latanoprost to bimatoprost.

in

low-risk patient

Cystoid macular edema

switching from latanoprost to bimatoprost

bimatoprost

latanoprost

latanoprost

bimatoprost


Input: Physicians should therefore be aware of its occurrence and carefully monitor serum levels of CPK, GOT and GPT during the treatment of diabetes insipidus with clofibrate, especially in patients with associated hypothyroidism, latent or overt, which possibly favors the development of myopathy.

development

patients with associated hypothyroidism, latent or overt

hypothyroidism

latent

overt

myopathy.

clofibrate

diabetes insipidus

clofibrate


Input: Flurbiprofen-associated acute tubulointerstitial nephritis.

associated

acute tubulointerstitial nephritis

Flurbiprofen

Flurbiprofen


Input: CONCLUSION: We believe this to be the first reported case of rhGH-induced hypercalcemia in an HIV-infected patient.

induced

an HIV-infected patient

hypercalcemia

rhGH

rhGH

HIV


Input: A case of basilar invagination which is thought to have arisen from the patient's intrauterine exposure to phenytoin is presented.

exposure

basilar invagination

phenytoin

phenytoin

intrauterine


Input: Methotrexate pneumonitis in nonsurgical treatment of ectopic pregnancy.

in

Methotrexate pneumonitis

nonsurgical treatment

ectopic pregnancy


Input: Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation.

developed

Two patients

Two

duodenal ulceration and subsequent intestinal perforation

receiving Tolazoline by infusion

Tolazoline

infusion


Input: We report the case of a 14-year-old female with acute promyelocytic leukemia who developed symptomatic cardiomyopathy only 4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA).

developed

a 14-year-old female with acute promyelocytic leukemia

female

symptomatic cardiomyopathy

4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA)

acute promyelocytic leukemia

4 months

daunomycin

all-trans retinoic acid

daunomycin

all-trans retinoic acid


Input: Hepatotoxicity seen with erlotinib, a small molecule tyrosine kinase inhibitor to EGFR, is usually transient with mild elevation of transaminases.

seen

Hepatotoxicity

transient with mild elevation of transaminases

erlotinib

erlotinib


Input: RESULTS: A previously healthy 42-year-old woman presented with acute-onset delirium with psychotic features as a consequence of levofloxacin therapy.

as a consequence of

A previously healthy 42-year-old woman

woman

acute-onset delirium with psychotic features

levofloxacin therapy

levofloxacin


Input: Although limb dyskinesia after methylphenidate is a commonly reported side effect, to the authors' knowledge this is only the second reported case to develop both orofacial and limb dyskinesia in the acute period after the first dose of methylphenidate.

develop

the second reported case

orofacial and limb dyskinesia

methylphenidate

methylphenidate

methylphenidate


Input: Phenylpropanolamine-induced psychosis.

induced

psychosis

Phenylpropanolamine

Phenylpropanolamine


Input: Graft versus host-like illness in a child with phenobarbital hypersensitivity.

hypersensitivity.

a child

child

Graft versus host-like illness

hypersensitivity

phenobarbital

phenobarbital


Input: The wide use of phenytoin during the recent tuberculosis epidemic makes it imperative to suspect this drug interaction in patients exhibiting clinical features that might be related to phenytoin toxicity.

suspect

patients

phenytoin toxicity

phenytoin

tuberculosis

phenytoin


Input: We report a case of MMC-related hemolytic uremic syndrome, and discuss the etiologic parameters, clinical aspects, prognosis and treatment modalities of this severe syndrome.

related

hemolytic uremic syndrome

MMC

MMC


Input: Myasthenic patients receiving ampicillin should be closely monitored for possible acute exacerbations.

receiving

Myasthenic patients

acute exacerbations

ampicillin

Myasthenic

ampicillin


Input: The male patient was treated with 225-mg/day clozapine and the time to the diagnosis of agranulocytosis was 6 weeks.

diagnosis

The male patient

male

agranulocytosis

225-mg/day clozapine

clozapine

6 weeks


Input: Alprazolam withdrawal delirium unresponsive to diazepam: case report.

to

diazepam

Alprazolam withdrawal delirium

diazepam


Input: These findings support previous studies that showed that the use of aspirin during the antecedent illness may be a risk factor for the development of RS.

development

RS

aspirin

the antecedent illness

aspirin


Input: Chloroquine-induced bilateral ptosis.

induced

bilateral ptosis

Chloroquine

Chloroquine


Input: DISCUSSION: To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept.

with

tuberculous uveitis

etanercept

etanercept


Input: Hyponatremia is a known adverse effect of duloxetine, and it can lead to potentially life-threatening complications.

adverse

Hyponatremia

potentially life-threatening complications

duloxetine

duloxetine


Input: A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg.

presented

A 22-year-old drug-abuser

drug-abuser

acute ischaemia of the left leg

injected flunitrazepam tablets dissolved in tap water into her left femoral artery

flunitrazepam

injected

tablets dissolved in tap water


Input: A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive pleuropulmonary abnormalities during the latter therapy.

developed

A patient with Parkinson's disease

progressive pleuropulmonary abnormalities during the latter therapy

initially treated with bromocriptine and subsequently with cabergoline

Parkinson's disease

bromocriptine

cabergoline


Input: Although interferon gamma has been implicated in the pathogenesis of sarcoidosis, only a few cases of sarcoidosis associated with interferon alpha therapy have been reported.

pathogenesis

sarcoidosis

interferon gamma

interferon gamma


Input: Camptocormia, a new side effect of sodium valproate.

of

Camptocormia

sodium valproate

sodium valproate


Input: Many patients with cardiac arrhythmias require concomitant therapy with warfarin and amiodarone.

require

Many patients with cardiac arrhythmias

concomitant therapy with warfarin and amiodarone

warfarin

amiodarone

cardiac arrhythmias

warfarin

amiodarone


Input: We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis.

treated

two patients with histologically confirmed adenocarcinoma of the prostate

two

femoral head avascular necrosis.

steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation

adenocarcinoma of the prostate

cyproterone acetate


Input: Thus, the possible in vivo effects of insulin on adipocytes were clearly observed in this case of insulin-induced lipohypertrophy.

induced

lipohypertrophy

insulin

insulin


Input: After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.

After

desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease

citalopram

citalopram


Input: Here we present the case of a woman who received high doses of methylprednisolone (1 g iv daily) for active Graves' ophthalmopathy, and developed severe hypertension followed by myocardial infarction on the fifth day of treatment.

received

a woman

woman

severe hypertension followed by myocardial infarction on the fifth day of treatment.

high doses of methylprednisolone (1 g iv daily)

methylprednisolone

1 g

iv

daily

active Graves' ophthalmopathy


Input: Severe cardiomyopathy following treatment with the tumour necrosis factor-alpha inhibitor adalimumab for Crohn's disease.

following

cardiomyopathy

treatment with the tumour necrosis factor-alpha inhibitor adalimumab

adalimumab

Crohn's disease


Input: There are now reports of liver failure following treatment of childhood cancers with AMD.

following

childhood cancers

childhood

liver failure

AMD

cancers

AMD


Input: Imatinib mesylate-related fatal acute hepatic failure in a patient with chronic myeloid leukaemia and chronic hepatitis B infection.

related

a patient with chronic myeloid leukaemia and chronic hepatitis B infection

chronic hepatitis B infection

fatal acute hepatic failure

Imatinib mesylate

Imatinib mesylate

chronic myeloid leukaemia


Input: This phase 3, randomized, double-blind 1-yr study assessed the effects of combined RLX and ALN in 331 postmenopausal women with osteoporosis (femoral neck BMD T-score, less than -2).

effects

331 postmenopausal women with osteoporosis (femoral neck BMD T-score, less than -2)

women

postmenopausal

combined RLX and ALN

osteoporosis

RLX

ALN

RLX

ALN


Input: Phenytoin toxicity due to concomitant antituberculosis therapy.

due

Phenytoin toxicity

concomitant antituberculosis therapy.

Phenytoin

antituberculosis

antituberculosis

Phenytoin


Input: Hemodialysis should be performed for rapid reversal of mannitol-induced ARF.

induced

ARF

mannitol

mannitol


Input: Amiodarone is well recognized as an anti-arrhythmic drug containing a high dose of iodine with considerable potential to cause thyroid dysfunction.

recognized

potential to cause thyroid dysfunction

Amiodarone

Amiodarone


Input: Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.

associated

Pulmonary infiltrates and skin pigmentation

sulfasalazine

sulfasalazine


Input: Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.

because

lithium intoxication with a diabetes insipidus-like syndrome

Lithium treatment

Lithium


Input: The authors report a longitudinal case study of a woman with a history of bipolar affective disorder in which L-dopa shortened the manic-depressive cycle length when administered in a double-blind trial.

shortened

a woman with a history of bipolar affective disorder

woman

bipolar affective disorder

shortened the manic-depressive cycle length

L-dopa

L-dopa


Input: Isoniazid causing breast tissue enlargement has been very rarely reported.

causing

breast tissue enlargement

Isoniazid

Isoniazid


Input: The induction of hypoglycaemia with PAS in this patient suggests a potential role for PAS in the treatment of diabetes mellitus.

induction

this patient

hypoglycaemia

PAS

PAS

diabetes mellitus


Input: Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.

recovered

both patients

both

vancomycin

colitis

vancomycin


Input: Acute dystonia during pegylated interferon alpha therapy in a case with chronic hepatitis B infection.

therapy

Acute dystonia

pegylated interferon alpha

chronic hepatitis B infection

pegylated interferon alpha


Input: I saw two patients with kala-azar resistant to sodium stibogluconate who developed cardiac arrest after amphotericin infusion (in spite of tolerating a test dose).

developed

two patients with kala-azar resistant to sodium stibogluconate

two

resistant to sodium stibogluconate

cardiac arrest

amphotericin infusion

kala-azar

amphotericin

infusion


Input: CONCLUSIONS: Anastrozole may be the causative factor in patients with sclerosing glomerulonephritis.

causative

patients

sclerosing glomerulonephritis

Anastrozole

Anastrozole


Input: We describe two cases of acute pancreatitis that occurred after long term mesalamine therapy for ulcerative colitis.

occurred

two cases

acute pancreatitis

mesalamine

ulcerative colitis

mesalamine


Input: Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.

by

toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia

Amphotericin B (AmB)

Amphotericin B


Input: We believe that a drug interaction between terfenadine and ketoconazole resulted in the elevated terfenadine levels in plasma and in the cardiotoxicity previously seen only in cases of terfenadine overdose.

resulted

the elevated terfenadine levels in plasma and in the cardiotoxicity

a drug interaction between terfenadine and ketoconazole

terfenadine

ketoconazole

terfenadine

ketoconazole


Input: A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity.

induced

a middle aged woman

middle aged

woman

hepatitis

halothane

gastric surgery for morbid obesity

halothane

morbid obesity


Input: Carbonic anhydrase inhibitors used in the treatment of glaucoma, seizure disorders, and hypertension are rarely associated with blood dyscrasias.

rarely associated

blood dyscrasias

Carbonic anhydrase inhibitors

Carbonic anhydrase inhibitors

glaucoma, seizure disorders, and hypertension


Input: Administration of intrathecal Ara-C in the same dose over longer intervals within 3-5 days between consecutive doses resulted in mild, transient neurological symptoms (paresthesias) in only one of 30 patients so treated.

resulted

one of 30 patients

one of 30

neurological symptoms

Administration of intrathecal Ara-C in the same dose over longer intervals within 3-5 days between consecutive doses

intrathecal

Ara-C

longer intervals within 3-5 days between consecutive doses


Input: Anaphylaxis from isoniazid is a possible side effect to this commonly prescribed antibiotic.

is

Anaphylaxis

isoniazid

commonly prescribed antibiotic

isoniazid


Input: Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).

developed

a patient with arrhythmogenic right ventricular dysplasia

thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII)

amiodarone for 4 years

4 years

amiodarone

arrhythmogenic right ventricular dysplasia


Input: Methotrexate-induced papular eruption following treatment of psoriasis.

induced

papular eruption

Methotrexate

psoriasis

Methotrexate


Input: Sexual dysfunction associated with intrathecal baclofen use: a report of two cases.

associated

two cases

two

Sexual dysfunction

intrathecal baclofen

intrathecal

baclofen


Input: Patients treated with L-asparaginase may present with hemorrhagic and thrombotic cerebrovascular events.

present

Patients

hemorrhagic and thrombotic cerebrovascular events

L-asparaginase

L-asparaginase


Input: Since imiquimod induces large amounts of type I interferon production from TLR7-expressing plasmacytoid dendritic cell precursors (PDCs), the natural interferon-producing cells of the peripheral blood, we asked whether PDCs are present in psoriatic skin.

induces

large amounts of type I interferon production

imiquimod

imiquimod


Input: Ptosis occurring 24 h after chloroquine therapy, with full recovery 48 h after cessation of chloroquine, has not been described previously.

occurring

Ptosis

full recovery 48 h after cessation of chloroquine

chloroquine therapy

24 h

chloroquine


Input: Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide.

associated

Hypersensitivity pneumonitis-like syndrome

lenalidomide

lenalidomide


Input: Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.

treated

pediatric cancer patients

pediatric

cancer

seizures

imipenem/cilastatin

imipenem

cilastatin

imipenem

cilastatin


Input: One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.

produce

patients treated with this drug or lepromatous leprosy

a ceroid-like pigment

clofazimine

lepromatous leprosy

clofazimine


Input: Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.

treatment

Deposits of plasma proteins in the skin

carbamazepine and diphenylhydantoin

carbamazepine

diphenylhydantoin

carbamazepine

diphenylhydantoin


Input: 2-Chloro-deoxyadenosine induces durable complete remission in Castleman's disease but may accelerate its transformation to non-Hodgkin's lymphoma.

accelerate

non-Hodgkin's lymphoma

Castleman's disease


Input: Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.

manifested

acute asthma

urticaria

angioedema

systemic anaphylactoid reaction

Hypersensitivity

aspirin

aspirin


Input: An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine.

associated

bradycardia

high-dose dexmedetomidine

dexmedetomidine

high-dose


Input: Only one patient, the youngest, did well on risperidone therapy.

did well

the youngest

risperidone

risperidone


Input: Two elderly women suffered an acute deterioration of renal function after treatment with cefoxitin sodium.

after

Two elderly women

Two

elderly

women

acute deterioration of renal function

treatment with cefoxitin sodium

cefoxitin sodium


Input: Physicians should suspect pulmonary toxicity in patients with respiratory distress after gemcitabine chemotherapy, mainly in elderly patients.

after

patients with respiratory distress

mainly in elderly patients

pulmonary toxicity

gemcitabine chemotherapy

gemcitabine

respiratory distress

chemotherapy


Input: Delay of corneal wound healing in patients treated with colchicine.

treated

patients

Delay of corneal wound healing

colchicine

colchicine


Input: Amiodarone-induced thyrotoxicosis associated with thyrotropin receptor antibody.

induced

thyrotoxicosis

Amiodarone

Amiodarone


Input: CONCLUSION: All doctors need to be aware of the need to review the indications for gabapentin use during periods of acute illness, especially with regard to renal impairment.

regard

renal impairment

gabapentin

acute illness

gabapentin


Input: EA signs were observed in all 7 patients in association with propofol TIVA but did not recur in any of 123 subsequent anesthetics sessions during which low-dose ketamine was added to propofol.

observed

all 7 patients

EA signs

propofol TIVA

low-dose ketamine was added to propofol

propofol

ketamine

propofol

TIVA

low-dose

propofol

ketamine


Input: The cause of death was multiple drug intoxication following acute use of sertraline, the manner of death was suicide, and the mechanism of death is an unexplained drug interaction and/or toxicity.

following

multiple drug intoxication

sertraline

sertraline


Input: On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred.

occurred.

gingival bleeding and purpura

On the next day, after a total dose of only 600 mg of danazol

danazol

a total dose of only 600 mg


Input: SLE receded after withdrawal of carbamazepine and treatment with anti-inflammatory drugs.

after

withdrawal of carbamazepine and treatment with anti-inflammatory drugs

carbamazepine

anti-inflammatory

SLE


Input: a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.

during

a 67-year-old man with bipolar disorder

man

Creutzfeldt-Jakob like syndrome

lithium carbonate

lithium carbonate

bipolar disorder


Input: A 42 year old man, treated for testicular carcinoma with combination chemotherapy that included bleomycin, developed life threatening interstitial pneumonitis.

developed

42 year old man

42 year old

man

interstitial pneumonitis

combination chemotherapy that included bleomycin,

testicular carcinoma

bleomycin


Input: Disseminated eruptive giant mollusca contagiosa in an adult psoriasis patient during efalizumab therapy.

during

an adult psoriasis patient

adult

Disseminated eruptive giant mollusca contagiosa

efalizumab therapy

psoriasis

efalizumab


Input: Significant clinical improvement of the porphyria followed withdrawal of the diphenylhydantoin.

improvement

withdrawal of the diphenylhydantoin

porphyria

diphenylhydantoin


Input: Temozolomide was restarted 2 months later; the patient again developed a fever.

developed

the patient

fever

Temozolomide

Temozolomide


Input: The patient's previous rash and the temporal relation of this event and the ingestion of phenolphthalein, as well as the similarity of this case to other reports, point to phenolphthalein as the cause of TEN in this patient.

cause

The patient's previous rash

rash

TEN

ingestion of phenolphthalein

phenolphthalein

ingestion


Input: Ciprofloxacin greatly elevates plasma concentrations of tizanidine and dangerously potentiates its hypotensive and sedative effects, mainly by inhibiting its CYP1A2-mediated metabolism, at least when administered 1 hour before tizanidine.

elevates

plasma concentrations of tizanidine and dangerously potentiates its hypotensive and sedative effects

Ciprofloxacin

Ciprofloxacin

tizanidine

tizanidine


Input: RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine.

developed

The patient, a 27-year-old married Japanese woman with borderline personality disorder

Japanese

woman

increased libido

administration of fluvoxamine

borderline personality disorder

fluvoxamine


Input: Acute renal failure with severe tubulointerstitial changes in a patient with minimal change nephrotic syndrome treated with enalapril.

in

a patient with minimal change nephrotic syndrome

Acute renal failure with severe tubulointerstitial changes

enalapril

enalapril

minimal change nephrotic syndrome


Input: PURPOSE: A case of carbamazepine-induced hyperammonemia is presented.

induced

A case

hyperammonemia

carbamazepine

carbamazepine


Input: The cough continued for the duration of therapy with quinapril.

continued

cough

quinapril

quinapril


Input: OBJECTIVE: To report a case of Carbamazepine toxicity following the administration of Oxybutynin and Dantrolene.

following

Carbamazepine toxicity

Carbamazepine

Oxybutynin and Dantrolene

Oxybutynin

Dantrolene

Carbamazepine

Carbamazepine

Oxybutynin

Dantrolene


Input: Danazol induced thrombocytopenia.

induced

thrombocytopenia

Danazol

Danazol


Input: Four elderly LTCF residents treated with serotonergic antidepressants including selective serotonin reuptake inhibitor (SSRI) or mirtazapine and opioids.

treated

Four elderly LTCF residents

Four

elderly

serotonergic antidepressants including selective serotonin reuptake inhibitor (SSRI) or mirtazapine and opioids

LTCF

selective serotonin reuptake inhibitor

mirtazapine

opioids

opioids

mirtazapine


Input: Detection of antineutrophil cytoplasmic antibody in a patient with L-tryptophan induced eosinophilia-myalgia syndrome.

induced

patient

eosinophilia-myalgia syndrome

L-tryptophan

L-tryptophan


Input: His impaired memory was found to be due to the atenolol he was on and he made a complete recovery on withdrawing the beta-blocker.

due

he

he

impaired memory

atenolol

atenolol


Input: Tiagabine overdose causes an unusual array of neurological symptoms, many similar to reported adverse effects during therapeutic use.

causes

an unusual array of neurological symptoms

Tiagabine overdose

Tiagabine

overdose


Input: This paper reports on a 6.9-year-old autistic male who developed repeated episodes of acute dystonic reactions associated with pimozide administration at the doses of 0.096 mg/kg/day and 0.032 mg/kg/day and 32 hours following pimozide withdrawal, as well as during subsequent thioridazine administration.

associated

6.9-year-old autistic male

autistic

male

repeated episodes of acute dystonic reactions

pimozide administration at the doses of 0.096 mg/kg/day and 0.032 mg/kg/day and 32 hours following pimozide withdrawal, as well as during subsequent thioridazine administration

pimozide

pimozide

thioridazine

0.096 mg/kg

0.032 mg/kg

day

day


Input: Cephalexin rash in infectious mononucleosis.

in

Cephalexin rash

Cephalexin

Cephalexin

infectious mononucleosis


Input: He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.

developed

recurrent skin rash, fever, hypereosinophilia, and acute renal failure

rechallenge with chlorambucil

chlorambucil


Input: Lower extremity arterial insufficiency after long-term methysergide maleate therapy.

after

Lower extremity arterial insufficiency

long-term methysergide maleate therapy

methysergide maleate

long-term


Input: Hepatolithiasis (intrahepatic stone) during octreotide therapy for acromegaly: a case report.

during

Hepatolithiasis (intrahepatic stone)

octreotide

octreotide

acromegaly


Input: Acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia: a case report.

after

Acute unilateral total visual loss

retrogasserian phenol injection

injection

retrogasserian phenol

trigeminal neuralgia


Input: OBJECTIVE: Clozapine causes few extrapyramidal symptoms and is recommended as a treatment drug for severe tardive dyskinesia (TD).

causes

few extrapyramidal symptoms

Clozapine

Clozapine


Input: Methylphenidate-induced acute orofacial and extremity dyskinesia.

induced

acute orofacial and extremity dyskinesia

Methylphenidate

Methylphenidate


Input: Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.

due

Basilar invagination and mid-line skeletal abnormalities

utero exposure to phenytoin

phenytoin


Input: DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.

triggered

neuralgic amyotrophy

antibiotics vancomycin, tobramycin, and piperacillin/tazobactam

vancomycin

tobramycin

piperacillin

tazobactam

vancomycin

tobramycin

piperacillin

tazobactam


Input: Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.

after

Alveolar-interstitial pneumopathy

gold-salts compounds administration

gold-salts compounds


Input: This study revealed that ketoconazole affected the disposition of rosiglitazone in humans, probably by the inhibition of CYP2C8 and CYP2C9, leading to increasing rosiglitazone concentrations that could increase the efficacy of rosiglitazone or its adverse events.

leading to

humans

increasing rosiglitazone concentrations that could increase the efficacy of rosiglitazone or its adverse events

ketoconazole

ketoconazole


Input: We report a case of duloxetine-induced hyponatremia in an elderly patient treated with thiazide diuretics.

induced

an elderly patient

elderly

hyponatremia

duloxetine

thiazide diuretics

duloxetine

thiazide diuretics

thiazide diuretics

duloxetine


Input: Protamine-induced fatal anaphylaxis.

induced

anaphylaxis

Protamine

Protamine


Input: We diagnosed this case as danazol induced thrombocytopenia.

induced

this case

thrombocytopenia

danazol

danazol


Input: One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.

treatment,

One patient

One

required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism

risperidone

risperidone


Input: NMS is a drug-related response to various medications, such as Haloperidol, which the patient was receiving.

response

patient

NMS

Haloperidol

Haloperidol


Input: In addition, ethambutol rarely causes visual loss during the early period or when given at lower doses.

causes

visual loss

ethambutol

during the early period or when given at lower doses

ethambutol

early period

lower doses


Input: The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.

stopped,

he

he

behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused

day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d

clozapine

clomipramine

150 mg/d