Input: Extensive forearm deep venous thrombosis following a severe infliximab infusion reaction.

following

Extensive forearm deep venous thrombosis

infusion reaction

infliximab

infliximab


Input: Severe acidosis from acetazolamide in a diabetic patient.

from

a diabetic patient

diabetic

Severe acidosis

acetazolamide

acetazolamide


Input: CONCLUSIONS: Clinicians should be aware that Crohn's disease is a potential novel adverse drug effect of Copaxone.

effect

Crohn's disease

Copaxone

Copaxone


Input: ADR induced by drug treatment can be a side effect of treatment with antipsychotic drugs and other drugs; however, there have been no reports of lamivudine-induced ADR in the English literature.

induced

ADR

lamivudine

lamivudine


Input: CONCLUSIONS: The piloerection observed after the replacement of fluvoxamine with milnacipran in this patient appears to have been due to an increase in the alpha(1)-adrenoceptor occupancy by endogenous norepinephrine induced by milnacipran.

induced

an increase in the alpha(1)-adrenoceptor occupancy by endogenous norepinephrine

milnacipran

milnacipran


Input: Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs.

from

Serotonin syndrome

interaction of cyclobenzaprine with other serotoninergic drugs

cyclobenzaprine

serotoninergic drugs


Input: However, a recent post-marketing survey in Japan revealed that interstitial pneumonia occurred in 4 among approximately 2 000 Japanese patients treated with sorafenib.

occurred

4 among approximately 2 000 Japanese patients

Japanese

4 among approximately 2 000

interstitial pneumonia

sorafenib

sorafenib


Input: The other patient developed transient intraoperative hypertension immediately after inadvertent submucosal injection of concentrated epinephrine.

developed

The other patient

transient intraoperative hypertension immediately

inadvertent submucosal injection of concentrated epinephrine

epinephrine

injection


Input: This experience supports the hypothesis that heparin can be readministered early to patients with heparin-associated thrombocytopenia and thrombosis, provided antiplatelet therapy is given.

readministered

heparin

antiplatelet therapy is given

heparin-associated thrombocytopenia

heparin

antiplatelet

antiplatelet

heparin


Input: Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.

during

Pneumonitis with pleural and pericardial effusion and neuropathy

amiodarone therapy

amiodarone


Input: We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.

induced

a case

interstitial pneumonitis

bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer

prostate cancer

bicalutamide

leuprorelin acetate

bicalutamide

leuprorelin acetate


Input: For those patients with a history of NMS, or even of isolated serum CK elevation during antipsychotic therapy, follow-up should be stricter.

during

patients with a history of NMS

a history of NMS

isolated serum CK elevation

antipsychotic therapy


Input: Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies.

risk

Children with acute lymphoblastic leukemia (ALL)

Children

cerebral thrombosis or hemorrhage

coagulation protein deficiencies

L-asparaginase

L-asparaginase

acute lymphoblastic leukemia (ALL)


Input: Two of the five patients who worsened motorically also developed encephalopathy during risperidone treatment; the encephalopathy resolved when the patients were switched to clozapine treatment.

developed

Two of the five patients who worsened motorically

Two of the five

worsened motorically

encephalopathy

risperidone treatment

risperidone


Input: The effectiveness of sugammadex in reversing rocuronium-induced neuromuscular blockade (NMB) in the presence of drugs that may potentiate NMB remains to be fully established.

induced

neuromuscular blockade (NMB)

rocuronium

rocuronium


Input: Dexamethasone treatment of amiodarone-induced thyrotoxicosis (AIT) with or without persistent administration of the drug.

induced

thyrotoxicosis (AIT)

amiodarone

amiodarone


Input: Acyclovir neurotoxicity: clinical experience and review of the literature.

experience

neurotoxicity

Acyclovir

Acyclovir


Input: Inadvertent exaggerated anticoagulation following use of bismuth subsalicylate in an enterally fed patient receiving warfarin therapy.

following

an enterally fed patient

Inadvertent exaggerated anticoagulation

bismuth subsalicylate

warfarin therapy

warfarin

bismuth subsalicylate


Input: We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both.

after

12 cases

hypertension

intraoperative use of topical phenylephrine, submucosal epinephrine, or both

phenylephrine

epinephrine

topical

submucosal

epinephrine

phenylephrine


Input: The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.

experienced

patient

muscle twitches, tremulousness, and anxiety

foscarnet therapy

foscarnet

on day 17


Input: A case of timolol-associated heart failure in a 73-year old white man is reported.

associated

a 73-year old white man

73-year old

white

man

heart failure

timolol

timolol


Input: In December, he was prescribed 160 mg/day tebipenem pivoxil by an otolaryngologist for inflammation of the tympanic membrane.

for

he

he

160 mg/day tebipenem pivoxil

inflammation of the tympanic membrane

160 mg/day

tebipenem pivoxil


Input: A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.

presented

A 65-year-old female patient

female

jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat

1 week after the fourth dose of adalimumab

adalimumab

1 week after

fourth dose


Input: Renal failure is a rare complication associated with the use of rifampicin for the treatment of tuberculosis, usually occurring well into the course of therapy.

associated

Renal failure

rifampicin

rifampicin

tuberculosis


Input: An autopsy case of multiple psychotropic drug poisoning.

poisoning.

An autopsy case

poisoning

multiple psychotropic drug

psychotropic


Input: Severe heparin associated thrombocytopenia is a rare complication of heparin therapy.

associated

thrombocytopenia

heparin

heparin


Input: Six patients at steady state in treatment with indinavir participated in the study.

treatment

Six patients

Six

indinavir

indinavir


Input: RESULTS: A 52-year-old woman with Parkinson disease who had taken amantadine for 6 years had bilateral corneal edema for 2 months at baseline.

had

A 52-year-old woman with Parkinson disease

woman

bilateral corneal edema for 2 months at baseline

taken amantadine for 6 years

Parkinson disease

amantadine

6 years


Input: We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.

presented

a patient with pulmonary hypertension and undifferentiated connective tissue disease

rapidly progressive erythema, scaling, nausea and vomiting, and fever

2 months of treatment with epoprostenol

epoprostenol

after 2 months

pulmonary hypertension

undifferentiated connective tissue disease


Input: Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.

receiving

adolescent

Neuroleptic malignant syndrome

olanzapine-lithium combination therapy

olanzapine

lithium

lithium

olanzapine


Input: A lethal complication of peripheral vein vasopressin infusion.

complication

complication

peripheral vein vasopressin infusion

peripheral vein

vasopressin


Input: Cutaneous eruptions occur in 3% of individuals administered carbamazepine.

occur

Cutaneous eruptions

carbamazepine

carbamazepine


Input: A 27 year old female with a complex history of congenital heart disease, cardiac surgery, heart failure, and arrhythmias was admitted for a Pseudomonas aeruginosa sternal wound infection and treated with intravenous antibiotics.

treated

A 27 year old female with a complex history of congenital heart disease, cardiac surgery, heart failure, and arrhythmias

27 year old

female

congenital heart disease

cardiac surgery

heart failure

arrhythmias

intravenous antibiotics

antibiotics

intravenous

a Pseudomonas aeruginosa sternal wound infection


Input: Hyperkalaemia with renal tubular dysfunction by oral therapy of sulfamethoxazole-trimethoprim (co-trimoxazole) is described in 2 elderly Japanese patients with lymphoid malignancy, who developed Pneumocystis carinii pneumonia and improved.

described

2 elderly Japanese patients with lymphoid malignancy

elderly

Japanese

lymphoid malignancy

Hyperkalaemia with renal tubular dysfunction

oral therapy of sulfamethoxazole-trimethoprim (co-trimoxazole)

oral

sulfamethoxazole-trimethoprim

Pneumocystis carinii pneumonia


Input: This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism.

induced

hypothyroidism

amiodarone

amiodarone


Input: Acute pulmonary reactions to nitrofurantoin are an uncommon side effect of therapy and can cause minor or life-threatening pulmonary dysfunction.

are

Acute pulmonary reactions

can cause minor or life-threatening pulmonary dysfunction

nitrofurantoin

nitrofurantoin


Input: High-dose cytosine arabinoside may benefit patients with refractory acute leukemia.

benefit

patients with refractory acute leukemia

High-dose cytosine arabinoside

refractory acute leukemia

High-dose

cytosine arabinoside


Input: Life-threatening hyponatremia caused by vinblastine.

caused

hyponatremia

vinblastine

vinblastine


Input: We report a myeloma patient who developed severe paralytic ileus during bortezomib therapy, which presented in the context of progressive constipation without other known causes and which regressed promptly with medical management after drug cessation, suggesting a direct causal relationship.

developed

a myeloma patient

paralytic ileus

presented in the context of progressive constipation without other known causes and which regressed promptly with medical management after drug cessation

bortezomib therapy

myeloma

bortezomib


Input: Here, we report on the drug safety of coumarin with special respect to liver reaction.

respect

liver reaction

coumarin

coumarin


Input: However, EO-induced noncardiogenic pulmonary edema has not been reported in human.

induced

human

noncardiogenic pulmonary edema

EO

EO


Input: Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.

Since

the thrombocyte count started to increase immediately after initiation and dropped immediately

discontinuation of ciprofloxacin and tazobactam/piperacillin

ciprofloxacin

tazobactam/piperacillin

discontinuation

tazobactam/piperacillin

ciprofloxacin


Input: However, in 1993, a clinical study involving 400 patients on the Thai-Burmese border revealed cardiac effects of antimalarial treatment with halofantrine, including one sudden death after the treatment.

effects

400 patients on the Thai-Burmese border

cardiac effects

sudden death

halofantrine

halofantrine

antimalarial treatment

halofantrine

antimalarial treatment


Input: Tetracycline-induced benign intracranial hypertension.

induced

benign intracranial hypertension

Tetracycline

Tetracycline


Input: Only one case of a generalized maculopapular rash with enoxaparin has been reported in Europe.

with

one case

one

generalized maculopapular rash

enoxaparin

enoxaparin


Input: After 3- to 13-month period of therapy without indapamide, glucose levels of all patients decreased and diabetes disappeared.

After

glucose levels of all patients decreased and diabetes disappeared

3- to 13-month period of therapy without indapamide

indapamide

3- to 13-month


Input: The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP.

induced

two patients

two

BOOP

nitrofurantoin

nitrofurantoin


Input: Skin necrosis after extravasation of low-dose vasopressin administered for septic shock.

extravasation

Skin necrosis

vasopressin

vasopressin

septic shock


Input: The patient was previously on phenytoin and was initiated on ticagrelor for antiplatelet therapy following stent placement.

for

The patient

previously on phenytoin

initiated on ticagrelor

following stent placement

antiplatelet therapy

phenytoin

ticagrelor


Input: Clonidine-induced bradycardia in patients with spinal cord injury.

induced

patients with spinal cord injury

bradycardia

Clonidine

spinal cord injury

Clonidine


Input: MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history of, or risk factors for, MI and tends to be associated with large cumulative doses of concentrate.

related

young patients who often have no preceding history of, or risk factors for, MI

young

MI

activated and non-activated PCCs

large cumulative doses of concentrate

non-activated PCCs

activated

PCCs

large cumulative doses


Input: To our knowledge, we describe the first reported case of isolated paresthesia and peripheral neuropathy, without systemic involvement, secondary to sulindac administration.

secondary

isolated paresthesia and peripheral neuropathy

sulindac administration

sulindac


Input: To report a probable case of ticlopidine-induced phenytoin toxicity.

induced

a probable case

phenytoin toxicity

phenytoin

ticlopidine

ticlopidine

phenytoin

ticlopidine

phenytoin


Input: Two patients are described in whom subtle cognitive impairments are associated with therapeutic doses of amoxapine.

associated

Two patients

Two

subtle cognitive impairments

therapeutic doses of amoxapine

therapeutic doses

amoxapine


Input: Itraconazole is particularly attractive in fungal prophylaxis for cancer patients due to its broad spectrum, including Candida and Aspergillus.

prophylaxis

cancer patients

cancer

Itraconazole

fungal

Itraconazole


Input: The authors think that although lamivudine is widely used and well tolerated, it can cause ADRs, which are reversible after drug withdrawal.

cause

ADRs

lamivudine

lamivudine


Input: Psoriasis induced by interferon-alpha.

induced

Psoriasis

interferon-alpha

interferon-alpha


Input: We report the first case of IHA associated with cefuroxime administration.

associated

the first case

IHA

cefuroxime

cefuroxime


Input: We report a 16-year-old male who developed nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus after treatment with griseofulvin.

after

a 16-year-old male

male

nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus

treatment with griseofulvin

griseofulvin


Input: CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.

In

some abstainers

thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes

take cyanamide for several years

cyanamide

several years


Input: Metabolic acidosis induced by acetazolamide.

induced

Metabolic acidosis

acetazolamide

acetazolamide


Input: In this paper we report a case of nimodipine overdosage resulting in prolonged hypotension and hypoxemia, which was successfully treated with calcium gluconate.

resulting

prolonged hypotension and hypoxemia

nimodipine overdosage

overdosage

nimodipine


Input: Valproic acid also displaces warfarin from the protein binding sites resulting in significant INR changes but this type of drug interaction is less well known.

resulting

significant INR changes

Valproic acid also displaces warfarin from the protein binding sites

Valproic acid

warfarin

Valproic acid

warfarin


Input: Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.

associated with

neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders

Therapy with IFN-alpha

IFN-alpha


Input: DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.

effects

diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions

leflunomide

leflunomide


Input: In a single practice during the 21 years 1971-1991, the incidence of gestational diabetes in pregnancies in which norethisterone was prescribed was 32.4% (22 of 69) in comparison with 7.1% in pregnancies in which the women did not take norethisterone (137 of 1,684) (p < 0.001).

incidence

pregnancies

gestational diabetes

norethisterone

norethisterone


Input: The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.

development

a patient with rheumatoid arthritis.

systemic lupus erythematosus

after 38 months

recombinant human interferon gamma

after 38 months

recombinant human interferon gamma

rheumatoid arthritis.


Input: To the best of our knowledge no comparable case and no discussion of possible complications of aspirin prophylaxis in patients with brain tumours have been published.

complications

patients with brain tumours

brain tumours

aspirin prophylaxis

aspirin


Input: CASE REPORT: We present a case of a 28-yr-old male who developed a severe case of nephrotic syndrome while being treated for relapsing/remitting Multiple Sclerosis (RRMS) with weekly injections of interferon beta 1a.

developed

28-yr-old male

relapsing/remitting Multiple Sclerosis (RRMS)

male

nephrotic syndrome

weekly injections of interferon beta 1a

weekly

injections

interferon beta 1a

relapsing/remitting Multiple Sclerosis


Input: This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis.

associated

patients with rheumatoid arthritis

reversible hepatic decompensation

MTX

rheumatoid arthritis

MTX


Input: CONCLUSIONS: Acute severe hepatitis though rare is occasionally observed with EGFR inhibitors gefitinib or erlotinib.

observed

Acute severe hepatitis

EGFR inhibitors gefitinib or erlotinib

gefitinib

erlotinib


Input: Propafenone is an established class IC antiarrhythmic drug commonly used in the treatment of atrial fibrillation.

treatment

Propafenone

atrial fibrillation

Propafenone


Input: Reversible nonthrombocytopenic palpable purpura associated with metoclopramide.

associated

Reversible nonthrombocytopenic palpable purpura

metoclopramide

metoclopramide


Input: Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine-induced lupus syndrome.

induced

lupus syndrome

sulfasalazine

sulfasalazine

sulfasalazine

sulfasalazine

inflammatory bowel disease


Input: Transient hemiparesis caused by phenytoin toxicity.

caused

Transient hemiparesis

phenytoin toxicity

phenytoin


Input: Sensorineural hearing loss due to quinine therapy for malaria has frequently been mentioned in the literature but has not been a subject of research during the last decades.

due

Sensorineural hearing loss

quinine

malaria

quinine


Input: We report a 78-year-old man who had acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia.

after

a 78-year-old man

man

acute unilateral total visual loss

retrogasserian phenol injection

trigeminal neuralgia

injection

phenol


Input: Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus.

due to

Four months after receiving an orthotopic liver transplant, a 51-year-old man

a 51-year-old

progressive liver failure and severe hepatocellular necrosis

tacrolimus

tacrolimus

Four months


Input: Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.

development

Patients

protamine hypersensitivity

neutral protamine Hagedorn (NPH) insulin

neutral protamine Hagedorn (NPH) insulin


Input: The second patient, who developed cholestasis after receiving trimethoprim-sulfamethoxazole, had marked duct paucity in the liver biopsy.

developed

The second patient

cholestasis

duct paucity

trimethoprim-sulfamethoxazole

trimethoprim-sulfamethoxazole


Input: We describe a patient who became hypothyroid while taking ferrous sulfate.

became

a patient

hypothyroid

ferrous sulfate

ferrous sulfate


Input: Allergy to cloxacillin with normal tolerance to amoxicillin and cefuroxime.

to

Allergy

cloxacillin

cloxacillin

amoxicillin

cefuroxime


Input: Triazolam-induced nocturnal bingeing with amnesia.

induced

nocturnal bingeing with amnesia

Triazolam

Triazolam


Input: Ticlopidine-induced aplastic anemia (TIAA) is considered very uncommon.

induced

aplastic anemia (TIAA)

Ticlopidine

Ticlopidine


Input: One case report describes an interaction between simvastatin and the anticoagulant acenocoumarol, which resulted in an elevated INR.

resulted

One case

One

elevated INR

simvastatin and the anticoagulant acenocoumarol

simvastatin

anticoagulant acenocoumarol

simvastatin

anticoagulant acenocoumarol


Input: A 35-year-old woman presented with neurotoxicity correlated to an i.v. regimen of 5-fluorouracil as episodes of acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum.

correlated

A 35-year-old woman

woman

neurotoxicity

acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum

an i.v. regimen of 5-fluorouracil

i.v.


Input: Ampicillin may aggravate clinical and experimental myasthenia gravis.

aggravate

myasthenia gravis

Ampicillin

Ampicillin


Input: In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine.

after

Japanese vivax malaria patient

Japanese

QT interval was prolonged

halofantrine

vivax malaria

halofantrine


Input: The Center for Disease Control has received numerous reports of an eosinophilia-myalgia syndrome related to products containing L-tryptophan.

related

eosinophilia-myalgia syndrome

products containing L-tryptophan

L-tryptophan


Input: Disopyramide (Norpace)-induced hypoglycemia.

induced

hypoglycemia

Disopyramide (Norpace)

Disopyramide


Input: A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.

treated

a patient

hypersensitivity syndrome

dapsone

dapsone

brown recluse spider bite


Input: AIMS: To present a case of piloerection after replacing fluvoxamine maleate with milnacipran hydrochloride, and to analyse this effect based on receptor occupancy theory.

after

piloerection

fluvoxamine maleate

fluvoxamine maleate

milnacipran hydrochloride


Input: Serotonin syndrome after concomitant linezolid and meperidine therapy has not been described.

after

Serotonin syndrome

linezolid and meperidine

linezolid

meperidine

linezolid

meperidine


Input: She presented to clinic with nausea and anorexia within a few days of addition of ciprofloxacin to her current regimen of medications, which included digoxin.

presented

She

She

nausea and anorexia

addition of ciprofloxacin to her current regimen of medications, which included digoxin

within a few days

ciprofloxacin

digoxin

ciprofloxacin

digoxin


Input: Disulfiram-induced fulminant hepatic failure in an active duty soldier.

induced

an active duty soldier

fulminant hepatic failure

Disulfiram

Disulfiram


Input: BACKGROUND: We report six cases of psychosis in patients with akinetic-rigid syndromes who were treated with risperidone.

treated

six cases

patients with akinetic-rigid syndromes

six

akinetic-rigid syndromes

risperidone

psychosis

risperidone


Input: Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol.

following

Colonic necrosis

Kayexalate (sodium polystryrene sulfonate) in sorbitol

Kayexalate

sorbitol

sorbitol

Kayexalate


Input: Anaphylaxis to cisplatin is an infrequent life-threatening complication which may occur even in patients who have received prior treatment with cisplatin.

occur

patients

Anaphylaxis

cisplatin

cisplatin


Input: Piloerection induced by replacing fluvoxamine with milnacipran.

induced

Piloerection

replacing fluvoxamine with milnacipran

milnacipran

fluvoxamine


Input: Ethambutol is an antimicrobial agent used frequently to treat tuberculosis.

treat

Ethambutol

tuberculosis

Ethambutol


Input: The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment.

complication

DIC

anti-D IGIV

anti-D IGIV


Input: Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis developed transient episodes of thyrotoxicosis during maintenance lithium therapy.

during

Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis

Four

Chinese

female

underlying autoimmune thyroiditis

transient episodes of thyrotoxicosis

maintenance lithium therapy

manic-depressive disorder

lithium


Input: Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication.

caused

raised intracranial pressure

valproic acid

valproic acid


Input: Primary ovarian large B-cell lymphoma in patient with juvenile rheumatoid arthritis treated with low dose Methotrexate.

in

patient with juvenile rheumatoid arthritis

Primary ovarian large B-cell lymphoma

low dose Methotrexate

juvenile rheumatoid arthritis

Methotrexate

low dose


Input: Asterixis induced by carbamazepine therapy.

induced

Asterixis

carbamazepine

carbamazepine


Input: Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies.

with

tubulopathies

Ifosfamide

Ifosfamide


Input: A case of noncardiogenic pulmonary edema by ethanolamine oleate.

by

A case

noncardiogenic pulmonary edema

ethanolamine oleate

ethanolamine oleate


Input: A boy with chronic neutropenia and recurrent inflammatory skin lesions developed multiple erythematous nodules following administration of G-CSF.

developed

A boy with chronic neutropenia and recurrent inflammatory skin lesions

boy

multiple erythematous nodules

G-CSF

chronic neutropenia and recurrent inflammatory skin lesions

G-CSF


Input: Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil.

due

Fulminant hepatitis

lymphocyte sensitization

propylthiouracil

propylthiouracil


Input: We report on three patients with acute schizophrenia, who developed severe akathisia during treatment with olanzapine (20-25 mg/d).

with

three patients with acute schizophrenia

three

akathisia

olanzapine (20-25 mg/d)

acute schizophrenia

olanzapine

20-25 mg/d


Input: AIMS/HYPOTHESIS: There is evidence that insulin and glucose cause renal and ocular vasodilation.

cause

renal and ocular vasodilation

insulin and glucose

glucose

insulin

insulin

glucose


Input: A cause-effect relationship to capecitabine was suggested due to resolution of headache with capecitabine withdrawal and reappearance with capecitabine rechallenge.

relationship to

headache

capecitabine

capecitabine


Input: This is a report of a case of anuric ARF after high-dose mannitol infusion for treatment of narrow-angle glaucoma that readily responded to acute hemodialysis.

after

a case

anuric ARF

high-dose mannitol infusion

mannitol

infusion

high-dose

narrow-angle glaucoma


Input: She was treated with sorafenib at 400 mg daily.

treated

She

She

sorafenib at 400 mg daily

sorafenib

400 mg

daily


Input: The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus, therefore, in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment.

provoked

type 1 diabetes mellitus

recombinant alpha-2b peginterferon plus ribavirin

recombinant alpha-2b peginterferon

ribavirin

ribavirin

recombinant alpha-2b peginterferon


Input: Rhabdomyolysis following clarithromycin monotherapy.

following

Rhabdomyolysis

clarithromycin monotherapy

clarithromycin


Input: In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.

effect on

gallbladder stasis

alters bile acid composition and may thus hasten intrahepatic sludge and stone formation

octreotide

octreotide


Input: A 17-year-old boy with acute lymphoblastic leukemia developed acute renal failure within 48 h of an intravenous high-dose methotrexate (5 g/m2) infusion.

developed

17-year-old boy with acute lymphoblastic leukemia

boy

acute renal failure

intravenous high-dose methotrexate (5 g/m2) infusion

intravenous

methotrexate

5 g/m2

within 48 h

acute lymphoblastic leukemia


Input: Splenic hemorrhage: a complication of tissue plasminogen activator treatment.

complication of

Splenic hemorrhage

tissue plasminogen activator treatment

tissue plasminogen activator


Input: CONCLUSIONS: Cefazolin was a probable cause of this patient's leukopenia.

cause

patient

leukopenia

Cefazolin

Cefazolin


Input: Paradoxical cerebral cortical hyperexcitability following flupirtine overdose.

following

Paradoxical cerebral cortical hyperexcitability

flupirtine overdose

flupirtine

overdose


Input: Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.

found

four leukemic patients

four

herpesvirus infection

large doses of cytarabine

cytarabine (cytosine arabinoside; Ara-C)

leukemic


Input: Heparin-induced hyperkalemia.

induced

hyperkalemia

Heparin

Heparin


Input: Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with DCF.

hazards

myelosuppression

immunosuppression and superinfection

DCF

DCF


Input: The photosensitivity is still present 3 years after the withdrawal of quinine.

after

photosensitivity is still present 3 years

withdrawal of quinine

quinine


Input: Interference with the cortisol axis by the microtubule antagonist, CPH82.

by

Interference with the cortisol axis


Input: Physicians should be aware of the possible association between the use of alteplase and the development of subfascial hemorrhage.

development

subfascial hemorrhage

alteplase

alteplase


Input: The clinical findings and laboratory studies suggested an autoimmune cell-mediated hypersensitivity reaction triggered by phenobarbital.

triggered

an autoimmune cell-mediated hypersensitivity reaction

phenobarbital

phenobarbital


Input: Anaphylactic reaction to oral prednisone: a case report and review of the literature.

to

a case

Anaphylactic reaction

oral prednisone

prednisone

oral


Input: Prolonged prostate-specific antigen response in flutamide withdrawal syndrome despite disease progression.

in

Prolonged prostate-specific antigen response

flutamide

flutamide


Input: None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.

received

the patient

cardiac arrest

doxorubicin

doxorubicin


Input: We report a case of IDDM which occurred during interferon therapy for chronic hepatitis.

occurred

a case

IDDM

interferon therapy

interferon

chronic hepatitis.


Input: Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.

associated

patients with HIV

SJS

nevirapine

nevirapine

HIV


Input: We report a case of baclofen withdrawal syndrome resulting from oral baclofen underdosing.

resulting

baclofen withdrawal syndrome

oral baclofen underdosing

oral

baclofen

underdosing


Input: A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril.

after

A 35-year-old nephrotic man

man

acute renal failure with serum creatinine to 1543 micromol/l

a month of therapy with enalapril

nephrotic

a month

enalapril


Input: Comparable adverse effects, such as disorientation and temporary amnesia, have been reported in patients in the analogous agent, propranolol.

been reported

patients

disorientation and temporary amnesia

propranolol

propranolol


Input: This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine.

after

a 13-year-old boy

boy

severe rash and systemic symptoms

oxcarbazepine

oxcarbazepine


Input: Renal damage associated with long term use of lithium carbonate.

associated

Renal damage

lithium carbonate

lithium carbonate.


Input: Triamcinolone acetonide induced secondary adrenal insufficiency related to impaired CYP3A4 metabolism by coadministration of nefazodone.

induced

secondary adrenal insufficiency

Triamcinolone acetonide

coadministration of nefazodone

Triamcinolone acetonide

nefazodone

nefazodone

Triamcinolone acetonide


Input: Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.

following

a child

child

Hepatocellular damage

intravenous iron sucrose infusion

iron sucrose

intravenous

infusion


Input: We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.

developed

a 43-year-old woman

woman

sore throat, swelling of the lips and oral cavity and dysphagia

2 weeks after the use of budesonide spray (Budefat)

2 weeks after

budesonide

Budefat

bronchial asthma.

spray


Input: Among the risk factors studied, two appear to increase the risk of ARE: the prescription of thiabendazole to treat strongyloidiasis during the melarsoprol cure and the bad general clinical conditions of patients.

appear to

increase the risk of ARE

prescription of thiabendazole

during the melarsoprol cure

thiabendazole

melarsoprol

strongyloidiasis


Input: Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.

of

pneumonitis

amiodarone

amiodarone


Input: A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine.

increasing

hepatic toxicity

interaction between clarithromycin and isradipine

clarithromycin

isradipine

clarithromycin

isradipine


Input: We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.

secondary

two cases

two

cerebrospinal fluid eosinophilia (CSFE)

intraventricular administration of vancomycin

intraventricular

vancomycin


Input: We describe two patients who experienced serious quetiapine adverse effects potentially mediated through an interaction with ritonavir-boosted atazanavir.

experienced

two patients

two

serious quetiapine adverse effects

ritonavir-boosted atazanavir

ritonavir

atazanavir

ritonavir

atazanavir


Input: The patient was diagnosed with carbamazepine toxicity related to the introduction of ritonavir.

related

patient

carbamazepine toxicity

ritonavir

ritonavir


Input: Caution should be exercised, especially in patients who are given voriconazole or fluconazole during long-lasting fentanyl treatment, because insidiously elevated fentanyl concentration may lead to respiratory depression.

lead

patients

respiratory depression

fentanyl

voriconazole

fluconazole

fentanyl

voriconazole

fluconazole


Input: This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.

following

DIC associated with acute hemoglobinemia or hemoglobinuria

anti-D IGIV administration

IGIV administration

anti-D

ITP


Input: Risperidone is a frequently used member of a new class of atypical antipsychotics-the serotonin-dopamine antagonists (SDAs)-due to its comparatively high efficacy and low D2/5HT2 binding ratio, which results in a low incidence of extrapyramidal side effects including tardive dyskinesia (TD).

results

tardive dyskinesia

Risperidone

Risperidone


Input: A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.

became

A 5-month-old infant

infant

lethargic and poorly responsive

receiving 1 drop of brimonidine in each eye

brimonidine

1 drop

in each eye


Input: The authors report 2 cases of renal damage associated with lithium carbonate treatment.

associated

2 cases

renal damage

lithium carbonate treatment

lithium carbonate


Input: It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.

leading

increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite

valproic acid may interfere with glucuronidation of lamotrigine

valproic acid

lamotrigine

valproic acid

lamotrigine


Input: Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.

during

a patient with severe haemophilia A and F V G1691A mutation

haemophilia A and F V G1691A mutation

Portal vein thrombosis

continuous infusion of F VIII

intramural jejunal bleeding

continuous infusion

F VIII


Input: A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.

exposed

A healthy, 30-year-old man

man

incapacitating isolated idential sensory neuropathy

sulindac

sulindac


Input: Clofibrate-induced myopathy in patients with diabetes insipidus.

induced

patients with diabetes insipidus

myopathy

Clofibrate

diabetes insipidus

Clofibrate


Input: This is the first histologically confirmed case of NASH that was aggravated by raloxifene.

aggravated

the first histologically confirmed case

NASH

raloxifene

raloxifene


Input: To date, eight cases of TEN and one of SJS related to lamotrigine administration have been reported in the literature.

related

TEN

SJS

lamotrigine

lamotrigine


Input: ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.

associated

dermatologic toxicity

ARA-C

ARA-C


Input: Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.

to

Hyperglycemia and diabetic coma

propranolol

propranolol


Input: Potential mechanisms involved in the occurrence of ischemic colitis in patients receiving tegaserod are also discussed.

occurrence

patients

ischemic colitis

tegaserod

tegaserod


Input: Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine: case report and review.

to

case

Anaphylaxis

intravenous cyclosporine

cyclosporine

intravenous


Input: CASE REPORT: A woman of 80 years, on long-term warfarin therapy presented with an acute dissecting thoracic aortic aneurysm; on investigation the only precipitating factor found was an international normalised ratio of 4.8.

presented

A woman of 80 years

woman

80 years

acute dissecting thoracic aortic aneurysm

on long-term warfarin

long-term

warfarin


Input: A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.

developed

A patient with an allergy to a macrolide antibiotic

allergy to a macrolide antibiotic

sudden cutaneous reaction

given tacrolimus

tacrolimus


Input: This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA.

treated

patients

extramedullary relapse

ATRA

ATRA


Input: Olanzapine-associated neuroleptic malignant syndrome.

associated

neuroleptic malignant syndrome

Olanzapine

Olanzapine


Input: Acute dystonia induced by lamivudine.

induced

Acute dystonia

lamivudine

lamivudine


Input: We report in detail an unusual adverse reaction to infliximab therapy, a drug-induced lupus-like clinical syndrome.

induced

lupus-like clinical syndrome

infliximab

infliximab


Input: RESULTS: Quetiapine was associated with leucopenia in two patients and clinically apparent agranulocytosis in one patient.

associated

two patients

two

leucopenia

Quetiapine

Quetiapine


Input: Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days.

after

the ileus spontaneously resolved

Oral intake and acarbose

acarbose

Oral intake


Input: No explanation for this delay was found, other than the possibility that magnesium sulfate treatment impeded lactogenesis.

impeded

lactogenesis

magnesium sulfate

magnesium sulfate


Input: Although its side effects are few, tamoxifen increases the incidence of proliferative lesions of the endometrium, which theoretically should be preventable with progestational agents.

increases

incidence of proliferative lesions of the endometrium

tamoxifen

tamoxifen


Input: Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate.

developed

Three senile patients

Three

senile

encephalopathy

calcium hopantenate

calcium hopantenate


Input: Renal injury due to anastrozole has not been published in the English literature.

due

Renal injury

anastrozole

anastrozole


Input: Facial, tongue, and arm movements were first reported approximately five weeks after the initiation of aripiprazole.

after

Facial, tongue, and arm movements

initiation of aripiprazole

five weeks

aripiprazole


Input: Restless legs syndrome due to interferon-alpha.

due

Restless legs syndrome

interferon-alpha

interferon-alpha


Input: HUS has been reported after several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens.

reported

HUS

several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens

mitomycin C


Input: Although the association between SJS/TEN and the sulfonamide class of antibiotics is well established, the increasing prevalence of CA-MRSA has left practitioners with limited regimens to effectively treat skin and soft tissue infections (SSTIs) in the outpatient setting.

association

CA-MRSA

CA-MRSA

SJS/TEN

sulfonamide class of antibiotics

sulfonamide class of antibiotics

skin and soft tissue infections (SSTIs)


Input: Acute non-lymphocytic leukemia occurred in eight women following long-term treatment with Treosulfan (= dihydroxybusulfan) for ovarian carcinoma.

occurred

eight women

eight

women

Acute non-lymphocytic leukemia

Treosulfan (= dihydroxybusulfan)

Treosulfan

dihydroxybusulfan

ovarian carcinoma


Input: Elderly patients for whom nitrate has been prescribed should be warned of the occurrence of hypotension, leading to unconsciousness.

occurrence

Elderly patients

Elderly

hypotension

unconsciousness

nitrate

nitrate


Input: A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.

had

a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips

vancomycin

vancomycin

serious staphylococcal infection


Input: Seven patients with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections developed eight episodes of major adverse cardiorespiratory and anaphylactic reactions.

developed

Seven patients with hematologic malignancies

Seven

hematologic malignancies

eight episodes of major adverse cardiorespiratory and anaphylactic reactions

miconazole

miconazole

fungal infections


Input: We report the first case, to our knowledge, of rituximab-related autoimmune hemolytic anemia.

related

autoimmune hemolytic anemia

rituximab

rituximab


Input: Anaphylactoid reactions with intraperitoneal cisplatin.

with

Anaphylactoid reactions

intraperitoneal cisplatin

intraperitoneal

cisplatin


Input: Tremor: a newly described adverse event with long-term itraconazole therapy.

with

Tremor

long-term itraconazole therapy

itraconazole

long-term


Input: Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma.

after

myelodysplastic syndrome

temozolomide

temozolomide

recurrent high-grade glioma


Input: It occasionally accompanies the heparin-associated thrombocytopenia and thrombosis syndrome.

associated

thrombocytopenia and thrombosis syndrome

heparin

heparin


Input: We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death.

resulting in

an unusual case

neurological and cardiovascular toxicity resulting in death

massive fluoxetine ingestion

fluoxetine

massive

ingestion


Input: Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration.

developed

an elderly asymptomatic asthmatic patient with hypertension

elderly

asymptomatic asthmatic

an acute asthma attack

sustained-release verapamil administration

sustained-release verapamil

hypertension


Input: The bleeding resolved on discontinuation of APV.

resolved

discontinuation of APV

The bleeding

APV


Input: We describe a case of infection with Mycobacterium abscessus in a 67-year-old woman receiving infliximab as a component of her therapy for RA.

receiving

a 67-year-old woman

RA

woman

infection with Mycobacterium abscessus

infliximab as a component of her therapy

infliximab

RA


Input: Renal toxicities have been reported in less than one percent of the patients receiving ciprofloxacin therapy.

reported

less than one percent of the patients

less than one percent

Renal toxicities

ciprofloxacin therapy.

ciprofloxacin


Input: Taxane-induced glaucoma.

induced

glaucoma

Taxane

Taxane


Input: Ciprofloxacin-induced toxic epidermal necrolysis in a patient with systemic lupus erythematosus.

induced

a patient with systemic lupus erythematosus.

toxic epidermal necrolysis

Ciprofloxacin

Ciprofloxacin

systemic lupus erythematosus


Input: Hypotension due to interaction between lisinopril and tizanidine.

due to

Hypotension

interaction between lisinopril and tizanidine

tizanidine

lisinopril

lisinopril

tizanidine


Input: Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.

following

extensive skin rash

MTX

MTX


Input: Anaphylactoid reaction to 50% solution of dextrose.

to

Anaphylactoid reaction

50% solution of dextrose

dextrose


Input: Hypokalemia after normal doses of neubulized albuterol (salbutamol).

after

Hypokalemia

normal doses of neubulized albuterol (salbutamol)

albuterol

salbutamol

normal doses


Input: Although praziquantel administration may have been effective in killing the parasite in both patients, we are concerned about the production of marked inflammation as a result of treatment.

production

parasite in both patients

both

marked inflammation

praziquantel

praziquantel

parasite


Input: We describe a patient who developed granulocytopenia and fever after taking dipyrone and discuss the available literature.

developed

a patient

granulocytopenia and fever

taking dipyrone

dipyrone


Input: Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.

before

symptomatic vision loss

hydroxychloroquine

hydroxychloroquine


Input: A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-beta therapy against malignant melanoma.

during

A 64-year-old man

man

proteinuria

postoperative interferon (IFN)-beta therapy

interferon (IFN)-beta

malignant melanoma


Input: Ethambutol toxicity manifesting as acute onset psychosis.

toxicity

acute onset psychosis

Ethambutol

Ethambutol


Input: Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.

after

Cholesterol crystal embolization-associated renal failure

therapy with recombinant tissue-type plasminogen activator

plasminogen activator


Input: METHODS: A 76-year-old woman with primary open-angle glaucoma and no history of ocular surgery developed a choroidal detachment 12 hours after initiation of therapy with dorzolamide eye drops.

developed

A 76-year-old woman with primary open-angle glaucoma and no history of ocular surgery

woman

choroidal detachment

12 hours after initiation of therapy with dorzolamide eye drops

12 hours

dorzolamide

open-angle glaucoma

eye drops


Input: Life-threatening hyperkalemia induced by arginine.

induced

hyperkalemia

arginine

arginine


Input: We report on three patients who developed acute liver damage during therapy with itraconazole, and in whom liver biopsy specimens were obtained.

developed

three patients

three

acute liver damage

itraconazole

itraconazole


Input: METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.

developed

A 68-year-old man

man

intense conjunctival hyperemia and cystoid macula edema

bimatoprost

cataract surgery

bimatoprost


Input: Tacrolimus (FK506), an immunosuppressant, has been associated with mutism in adults after liver transplant.

associated with

adults after liver transplant

adults

liver transplant.

mutism

Tacrolimus (FK506), an immunosuppressant

Tacrolimus


Input: Gemcitabine-induced pulmonary toxicity is usually a dramatic condition.

induced

pulmonary toxicity

Gemcitabine

Gemcitabine


Input: However, the amount of prednisone required to maintain normotension resulted in Cushingoid features and has been discontinued.

resulted in

Cushingoid features

prednisone

to maintain normotension

prednisone


Input: We present the case of a woman undergoing treatment with acenocoumarol for deep vein thrombosis, who maintained an international normalized ratio (INR) of between 2.5 and 4 for 2 months.

treatment

a woman

woman

acenocoumarol

acenocoumarol

deep vein thrombosis


Input: Development of tics in a thirteen-year-old male following atomoxetine use.

following

a thirteen-year-old male

thirteen-year-old

male

Development of tics

atomoxetine

atomoxetine


Input: OBJECTIVE: To report a case of chronic, nonproductive cough secondary to the angiotensin-converting enzyme (ACE) inhibitor quinapril, with complete resolution after switching to another ACE inhibitor, fosinopril.

resolution

chronic, nonproductive cough secondary to the angiotensin-converting enzyme (ACE) inhibitor quinapril

switching to another ACE inhibitor, fosinopril

fosinopril


Input: Cholelithiasis and thrombosis of the central retinal vein in a renal transplant recipient treated with cyclosporin.

in

a renal transplant recipient

renal transplant

Cholelithiasis and thrombosis of the central retinal vein

cyclosporin

cyclosporin


Input: We report a case of hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis in a 37 year old male with acromegaly being treated with octreotide.

in

a 37 year old male with acromegaly

37 year old

male

hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis

octreotide

octreotide

acromegaly


Input: Proliferation of abnormal bone marrow histiocytes, an undesired effect of granulocyte macrophage-colony-stimulating factor therapy in a patient with Hurler's syndrome undergoing bone marrow transplantation.

undesired effect

a patient with Hurler's syndrome

Proliferation of abnormal bone marrow histiocytes

granulocyte macrophage-colony-stimulating factor

granulocyte macrophage-colony-stimulating factor

Hurler's syndrome


Input: We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.

presented

acral cyanosis, livedo reticularis, or Raynaud phenomenon

dextroamphetamine

dextroamphetamine


Input: Described here are 2 patients who developed thrombotic microangiopathy of the kidneys after receiving high cumulative doses of the new anticancer drug gemcitabine.

receiving

2 patients

thrombotic microangiopathy of the kidneys

gemcitabine

high cumulative doses

gemcitabine


Input: CONCLUSIONS: An objective causality assessment revealed that fluphenazine was the probable cause of NMS in this patient.

cause

patient

NMS

fluphenazine

fluphenazine


Input: Like other atypical neuroleptics olanzapine is considered to show a reduced prevalence of extrapyramidal side effects when compared to classical neuroleptic drugs.

show

reduced prevalence of extrapyramidal side effects

olanzapine

olanzapine

neuroleptic drugs.


Input: Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.

present

all ED patients

altered mental status

valproic acid therapy

ED

valproic acid


Input: Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.

associated

myelosuppression, hypertension, hyperlipidemia, and infection

Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia)

Rapamycin/sirolimus


Input: Enoxaparin-induced generalized exanthem.

induced

generalized exanthem

Enoxaparin

Enoxaparin


Input: Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.

of

hepatotoxicity

(sub)fulminant hepatitis and cirrhosis

benzarone

benzarone

benzarone


Input: Within 3 days after starting bismuth subsalicylate therapy, the patient's INR increased from 2.56 to 3.54 and minor bleeding was noted from the patient's tracheostomy site.

noted

the patient

INR increased from 2.56 to 3.54 and minor bleeding was noted from the patient's tracheostomy site

Within 3 days after starting bismuth subsalicylate therapy

3 days

bismuth subsalicylate


Input: After three weeks of carbamazepine therapy, the patient arrived at the emergency department (ED) with severe agitation and aggressive behavior.

After

patient

severe agitation and aggressive behavior

After three weeks of carbamazepine therapy

three weeks

carbamazepine


Input: OBJECTIVE: To report a case of ciprofloxacin-induced psychosis and to discuss occurrence rates, risk factors, possible etiologies, preventive measures, and treatment courses for this adverse reaction.

induced

psychosis

ciprofloxacin

ciprofloxacin


Input: A 77-year-old man developed ankle, hand, and facial swelling 2 weeks after starting rosiglitazone.

developed

A 77-year-old man

man

ankle, hand, and facial swelling

2 weeks after starting rosiglitazone

2 weeks

rosiglitazone


Input: Although rare, massive pulmonary embolus must be considered to be a major risk of thrombolytic therapy for deep venous thrombosis.

risk

massive pulmonary embolus

thrombolytic

thrombolytic


Input: We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.

after

a cachectic AIDS patient with protracted diarrhoea

cachectic AIDS

protracted diarrhoea

hypoglycaemia

mefloquine therapy (1,500 mg over two days)

severe gastrointestinal cryptosporidiasis

mefloquine

1,500 mg


Input: OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.

associated with

syndrome of inappropriate antidiuretic hormone (SIADH)

vinorelbine

vinorelbine

advanced breast cancer


Input: The thiazolidinediones (rosiglitazone and pioglitazone), a new class of oral antidiabetic agents, are "insulin sensitizers" and exert direct effects on the mechanisms of insulin resistance.

exert

thiazolidinediones

insulin resistance


Input: The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy.

detected

exacerbation of psoriasis

a massive induction of lesional type I interferon activity

imiquimod

imiquimod


Input: Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.

developed

Two patients

Two

a bipolar disorder

lithium-responsive manic episodes

alprazolam

alprazolam


Input: Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.

complications

children with leukemia

children

Cerebrovascular complications

aphasia and other neuropsychological deficits

L-asparaginase

L-asparaginase

leukemia


Input: We report two patients who developed intense livedo reticularis clearly related to the administration of interferon alpha 2b as an adjuvant therapy for melanoma.

related

two patients

two

intense livedo reticularis

interferon alpha 2b as an adjuvant therapy for melanoma

interferon alpha 2b

melanoma


Input: A case of SIADH associated with desipramine treatment in an elderly depressed woman is described.

associated

an elderly depressed woman

elderly

woman

SIADH

desipramine treatment

depressed

desipramine


Input: Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis?

induced

skeletal fluorosis

Niflumic acid

Niflumic acid


Input: Both patients developed severe complications when treated with aminoglutethimide as a cancer hormonal therapy.

developed

Both patients

severe complications

aminoglutethimide

cancer

aminoglutethimide


Input: An 11-day-old infant became lethargic and apneic after a single drop of brimonidine.

became

An 11-day-old infant

infant

lethargic and apneic

a single drop of brimonidine

single drop

brimonidine


Input: Investigations suggested that the dextrose, rather than any additives, was responsible for the reaction.

responsible

the reaction

dextrose

dextrose


Input: Since renal insufficiency was induced by AMPH and the other antifungal drugs were ineffective, daily administration of 200 mg of ITCZ was initiated, and the inflammatory signs and symptoms gradually subsided.

initiated,

the inflammatory signs and symptoms gradually subsided.

daily administration of 200 mg of ITCZ

renal insufficiency

200 mg

daily administration

ITCZ


Input: Correction of serum electrolyte imbalance prevents cardiac arrhythmia during amphotericin B administration.

during

cardiac arrhythmia

amphotericin B administration

amphotericin B


Input: Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.

following

Acute myopathy with selective degeneration of myosin filaments

methylprednisolone

vecuronium

asthmaticus

methylprednisolone

vecuronium

vecuronium

methylprednisolone


Input: Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma.

induced

acute renal failure

acetazolamide therapy for glaucoma

acetazolamide

glaucoma


Input: Cyanamide-induced liver dysfunction after abstinence in alcoholics: a long-term follow-up study on four cases.

induced

abstinence in alcoholics

liver dysfunction

Cyanamide

Cyanamide


Input: Fewer subjects reported adverse events following treatment with desipramine alone than when receiving desipramine with cinacalcet (33 versus 86%), the most frequent of which (nausea and headache) have been reported for patients treated with either desipramine or cinacalcet.

reported

patients

nausea and headache

desipramine or cinacalcet

desipramine

cinacalcet

desipramine

desipramine

cinacalcet

desipramine

cinacalcet


Input: Three patients developed proteinuria following gold therapy for rheumatoid arthritis.

following

Three patients

Three

proteinuria

gold

rheumatoid arthritis

gold


Input: The authors report a case of a patient who received alteplase for acute myocardial infarction and developed spontaneous subfascial hematoma without any evidence of direct trauma.

developed

a case of a patient

spontaneous subfascial hematoma without any evidence of direct trauma

alteplase

acute myocardial infarction

alteplase


Input: Ticlopidine-induced marrow aplasia treated with cyclosporine.

induced

marrow aplasia

Ticlopidine

Ticlopidine


Input: Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate, prednisone, and asparaginase.

developed

two children with acute lymphoblastic leukemia

two

children

Dural sinus thrombosis

induction treatment with vincristine sulfate, prednisone, and asparaginase

vincristine sulfate

prednisone

asparaginase

acute lymphoblastic leukemia

vincristine sulfate

prednisone

asparaginase


Input: Zolpidem (Ambien), a relatively new nonbenzodiazepine sedative-hypnotic, was involved in the death of a 39-year-old obese male who was being treated for depression and insomnia.

involved

a 39-year-old obese male

obese

male

death

Zolpidem (Ambien)

depression and insomnia

Zolpidem


Input: A MEDLINE search identified all the reported cases of hypersensitivity reactions to cyclosporine.

reactions

hypersensitivity reactions

cyclosporine

cyclosporine


Input: METHODS: A 79-year-old woman being treated with imiquimod 5 days per week for a nodular basal cell developed a verrucous plaque over the treatment area after 7 weeks of therapy.

developed

A 79-year-old woman

woman

verrucous plaque

imiquimod 5 days per week

after 7 weeks

nodular basal cell

imiquimod

5 days per week

7 weeks


Input: Oxcarbazepine, a metabolite of carbamazepine, is used as an antiepileptic, analgesic for neuropathic pain and in the treatment of affective disorders.

used

antiepileptic, analgesic

Oxcarbazepine

neuropathic pain

affective disorders

Oxcarbazepine


Input: PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.

developed

A 34-year-old woman with chronic hepatitis C, genotype 3

woman

genotype 3

progressive malaise and anemia

pegylated interferon alpha-2a and ribavirin for 6 months

6 months

pegylated interferon alpha-2a

ribavirin

6 months

chronic hepatitis C

ribavirin

pegylated interferon alpha-2a


Input: We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v.

induced

bradycardia with i.v

treatment of dexmedetomidine

dexmedetomidine


Input: Esmolol, an ultrashort-acting beta 1-selective antagonist, controlled her multiple dysrhythmias and symptoms of sympathetic nervous system hyperstimulation.

controlled

her

Esmolol, an ultrashort-acting beta 1-selective antagonist

multiple dysrhythmias and symptoms of sympathetic nervous system hyperstimulation

Esmolol


Input: (Case 1) A 29-year-old woman with overdose of metaxalone presented to the emergency department with altered mental status, seizure-like activity, hyperthermia, rigidity in the lower extremities, myoclonus, and hyperreflexia.

presented

A 29-year-old woman

woman

altered mental status, seizure-like activity, hyperthermia, rigidity in the lower extremities, myoclonus, and hyperreflexia

metaxalone

metaxalone

overdose


Input: Warfarin and boceprevir interaction causing subtherapeutic international normalized ratio: a case report.

causing

subtherapeutic international normalized ratio

Warfarin

boceprevir

Warfarin

boceprevir

Warfarin

boceprevir


Input: A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature, as well as possible alternative explanations in this case, are provided.

of

hypersensitivity

chloramphenicol

chloramphenicol


Input: Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy.

following

amiodarone pulmonary toxicity

corticosteroid

amiodarone

corticosteroid


Input: In the present study, arsenic trioxide was given intravenously for 42 days to a 56-year-old female patient suffering from chemotherapy/ATRA-resistant APL, with 43% APL blasts in the bone marrow and elevated D-dimers.

given

56-year-old female patient

female

arsenic trioxide

arsenic trioxide

chemotherapy/ATRA-resistant APL

42 days


Input: We assume that rIFN-gamma induced the de novo development of SLE in our patient.

induced

our patient

the de novo development of SLE

rIFN-gamma

rIFN-gamma


Input: Interstitial pneumopathy and low-dosage amiodarone.

and

Interstitial pneumopathy

low-dosage amiodarone

amiodarone

low-dosage


Input: CONCLUSIONS: These results suggest that clozapine may cause TD; however, the prevalence is low and the severity is relatively mild, with no or mild self-reported discomfort.

cause

TD

clozapine

clozapine


Input: Hepatotoxicity resolved once erlotinib was discontinued and serum transaminases returned to baseline normal values.

discontinued

Hepatotoxicity

erlotinib

Hepatotoxicity

erlotinib


Input: CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustained-release verapamil and were relieved after its discontinuation.

cause

asthma attack

Sustained-release verapamil

verapamil


Input: A patient developed cholestatic hepatitis while being treated with nitrofurantoin.

developed

cholestatic hepatitis

nitrofurantoin

nitrofurantoin


Input: Severe apnea in an infant exposed to lamotrigine in breast milk.

in

an infant

infant

apnea

lamotrigine

lamotrigine

breast milk


Input: Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.

developed

a 43-year-old man

man

Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies

long-term sulfasalazine

chronic ulcerative colitis

sulfasalazine


Input: Bone formation induced in an infant by systemic prostaglandin-E2 administration.

induced

an infant

infant

Bone formation

systemic prostaglandin-E2 administration

systemic

administration


Input: A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.

induced

these patients

hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase

A high dose of cotrimoxazole

after several days of the drug administration

high dose

cotrimoxazole

several days


Input: Angioedema, a rare side effect of carbamazepine, involves vascular leakage in dermis and subcutis mediated by immunoglobulin E and/or bradykinins.

of

Angioedema

involves vascular leakage in dermis and subcutis mediated by immunoglobulin E and/or bradykinins

carbamazepine

carbamazepine


Input: A diagnosis of trastuzumab-induced pneumonitis was made.

induced

pneumonitis

trastuzumab

trastuzumab


Input: We present a case of HUS in an advanced ovarian cancer patient treated with carboplatin and gemcitabine, and described its favorable outcome after chemotherapy interruption and supportive care with a 1 year follow-up.

treated

HUS

carboplatin and gemcitabine

advanced ovarian cancer

carboplatin

gemcitabine

carboplatin

gemcitabine


Input: Several such HBV reactivations were reported after combined rituximab and multiagent chemotherapy for B-cell lymphomas.

after

Several such HBV reactivations

combined rituximab and multiagent chemotherapy

rituximab

B-cell lymphomas

chemotherapy


Input: Thus, the eosinophilia myalgia syndrome can be associated with parenteral tryptophan administration.

associated

eosinophilia myalgia syndrome

parenteral tryptophan

tryptophan

parenteral


Input: Generalized pustular psoriasis precipitated by trazodone in the treatment of depression.

precipitated

Generalized pustular psoriasis

trazodone

depression

trazodone


Input: We report a case of Sweet's syndrome in association with sargramostim treatment following chemotherapy for acute myelogenous leukemia.

association

Sweet's syndrome

sargramostim treatment following chemotherapy

sargramostim

chemotherapy

acute myelogenous leukemia


Input: This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue.

develop

patients

hypersensitivity reactions

carboplatin

carboplatin


Input: We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose.

developed

a neonate with a seizure disorder

neonate

pupillary mydriasis

lidocaine overdose

lidocaine

overdose

seizure disorder


Input: Based on the Naranjo algorithm, the adverse reaction observed was probably related to the hydroxyurea treatment (score = 6); however, the hydroxyurea chemotherapy could not be discontinued because of the myeloproliferative disorder.

related

myeloproliferative disorder

hydroxyurea chemotherapy

hydroxyurea

hydroxyurea

chemotherapy


Input: Extrapyramidal side effects induced by some selective serotonin reuptake inhibitors (SSRIs), i.e. fluoxetine and sertraline, have been previously reported in patients with depression and obsessive-compulsive disorder (OCD).

induced by

patients with depression and obsessive-compulsive disorder (OCD)

Extrapyramidal side effects

some selective serotonin reuptake inhibitors (SSRIs), i.e. fluoxetine and sertraline

depression

obsessive-compulsive disorder (OCD)

fluoxetine

sertraline

serotonin reuptake inhibitors


Input: Ten-17 days after receiving chemotherapy, five patients (4 males and 1 female) with acute lymphoblastic leukemia developed incapacitating myalgias in neck, thighs and arms.

developed

five patients (4 males and 1 female) with acute lymphoblastic leukemia

five

4 males and 1 female

incapacitating myalgias in neck, thighs and arms

Ten-17 days after receiving chemotherapy

acute lymphoblastic leukemia

Ten-17 days

chemotherapy


Input: We report a case of a potential drug-drug interaction in a woman treated by a first injection of high-dose methotrexate for a T-lymphoblastic lymphoma.

treated

a woman

woman

a first injection of high-dose methotrexate

a T-lymphoblastic lymphoma

injection

high-dose

methotrexate


Input: We conclude that myocardial infarction may develop in patients treated with high-dose glucocorticoids for Graves' ophthalmopathy, and increased blood pressure may herald this complication.

develop

patients

myocardial infarction

increased blood pressure

high-dose glucocorticoids

glucocorticoids

high-dose

Graves' ophthalmopathy


Input: A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.

developed

40-year-old man with relapsing-remitting multiple sclerosis (MS)

man

primary central nervous system lymphoma (PCNSL)

21 doses of natalizumab monotherapy

relapsing-remitting multiple sclerosis (MS)

21 doses

natalizumab


Input: Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction.

caused

Serotonin syndrome

selective serotonin reuptake-inhibitors-metoclopramide interaction

metoclopramide

selective serotonin reuptake-inhibitors

metoclopramide

selective serotonin reuptake-inhibitors


Input: This is the first reported case of suspected DIAN due to cefuroxime.

due to

first reported case

DIAN

cefuroxime

cefuroxime


Input: We report a cae of paranoid psychosis following use of a decongestant containing PPA and summarize the case report literature of psychiatric adverse effects to PPA in which doses were known and stated to be within recommended guidelines.

following

a cae

paranoid psychosis

decongestant containing PPA

PPA


Input: Liver transplantation for fulminant hepatitis related to nevirapine therapy.

related

Liver transplantation for fulminant hepatitis

nevirapine therapy

nevirapine


Input: OBJECTIVE: To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy.

owing

a patient with mucositis secondary to chemotherapy

hyperkalemia

succinylcholine administration

mucositis

succinylcholine


Input: We describe a case of prolonged terbinafine-induced cholestatic liver disease.

induced

a case

cholestatic liver disease

prolonged terbinafine

terbinafine


Input: We describe a case of interstitial hypoxaemiant pneumonitis probably related to flecainide in a patient with the LEOPARD syndrome, a rare congenital disorder.

related

a patient with the LEOPARD syndrome

interstitial hypoxaemiant pneumonitis

flecainide

flecainide

LEOPARD syndrome


Input: This case showed sequential manifestation from transient thyrotoxicosis to the appearance of TSH-receptor autoantibodies, and then the occurrence of Graves' hyperthyroidism during IFN therapy.

occurrence

This case

Graves' hyperthyroidism

IFN therapy

IFN


Input: Halothane hepatitis and prompt resolution with methionine therapy: case report.

resolution

case

methionine

Halothane hepatitis

methionine


Input: This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate.

exposed

a previously healthy young woman

young

woman

hepatitis

2 doses of amodiaquine and artesunate

2 doses

amodiaquine

artesunate

amodiaquine

artesunate


Input: It was restarted 6 weeks later, and 10 weeks after that, the patient presented with fulminant hepatic failure, which resolved rapidly after cessation of nicotinic acid therapy.

presented

the patient

fulminant hepatic failure

10 weeks after

nicotinic acid

10 weeks after

nicotinic acid


Input: We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low-molecular weight heparin therapy at sites distant from injection sites.

develop

a patient with the antiphospholipid syndrome

skin necrosis

low-molecular weight heparin therapy at sites distant from injection sites

antiphospholipid syndrome

low-molecular weight heparin

injection


Input: While CYP form induction by Pyrethrins, Phenobarbital and related compounds can be associated with liver and thyroid gland tumour formation in rodents, epidemiological data for Phenobarbital suggests that such effects do not occur in humans.

induction

liver and thyroid gland tumour formation in rodents

Pyrethrins, Phenobarbital and related compounds

Pyrethrins

Phenobarbital

related compounds

related compounds

Phenobarbital

Pyrethrins


Input: Disulfiram encephalopathy as a cause of the catatonia syndrome.

cause

catatonia syndrome

encephalopathy

Disulfiram

Disulfiram


Input: Little has been studied of the adverse effects of the exposure of the liver to the interaction of ethanol with its congeners and acetaldehyde, coexisting in the contents of alcoholic beverages.

interaction

adverse effects of the exposure of the liver

ethanol with its congeners and acetaldehyde

acetaldehyde

ethanol

ethanol

acetaldehyde


Input: Fatal serotonin syndrome precipitated by oxcarbazepine in a patient using an selective serotonin reuptake inhibitor.

precipitated

a patient

serotonin syndrome

oxcarbazepine

oxcarbazepine


Input: This eruption emerged after 1 month of therapy with salsalate, persisted for as long as salsalate was administered, and cleared within 3 weeks of discontinuing the medication.

emerged

eruption

after 1 month of therapy with salsalate

1 month

salsalate


Input: A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement.

following

a patient

pulmonary vasoconstriction and right ventricular failure

infusion of protamine

undergoing coronary artery bypass surgery and mitral valve replacement

protamine

infusion


Input: When cyanamide-treated alcoholics relapse into drinking, more severe inflammation develops in the liver.

develops

cyanamide-treated alcoholics

inflammation

cyanamide

cyanamide

alcoholics


Input: Acute renal failure should be recognized as a potential complication of suramin treatment.

complication

Acute renal failure

suramin treatment

suramin


Input: After induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride, her cardiac rhythm progressed to asystole.

After

her

her

asystole

induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride

intravenous

esmolol hydrochloride

general anesthesia

general anesthesia

esmolol hydrochloride


Input: Exacerbation of schizophrenia associated with amantadine.

associated

Exacerbation of schizophrenia

amantadine

amantadine


Input: Priapism as a complication of heparin therapy.

complication

Priapism

heparin

heparin


Input: Torsades de pointes occurring in association with terfenadine use.

association

Torsades de pointes

terfenadine

terfenadine


Input: Protamine allergy as a complication of insulin hypersensitivity: A case report.

complication

hypersensitivity

Protamine allergy

insulin

insulin


Input: We report a case of recurrent torsades de pointes following treatment with pentavalent antimonial drugs and amiodarone.

treatment with

recurrent torsades de pointes

pentavalent antimonial drugs and amiodarone

amiodarone

pentavalent antimonial drugs

pentavalent antimonial drugs

amiodarone


Input: This case presentation is of a patient who had the clinical appearance of epiglottitis, but actually had an oro-pharyngeal dystonic reaction to prochlorperazine.

had

a patient

clinical appearance of epiglottitis

actually had an oro-pharyngeal dystonic reaction

prochlorperazine

prochlorperazine


Input: Localized dyskeratotic plaque with milia associated with sorafenib.

associated

Localized dyskeratotic plaque with milia

sorafenib

sorafenib


Input: The authors describe a case of the catatonia syndrome associated with disulfiram therapy.

associated

catatonia syndrome

disulfiram therapy

disulfiram


Input: Most of the clinical data on the safety profile of desmopressin (DDAVP), which is an effective treatment for both polyuric conditions and bleeding disorders, originate from studies on the tailoring of drug treatment, whereas few reports exist describing severe side effects secondary to drug-drug interaction.

treatment

both polyuric conditions and bleeding disorders

desmopressin (DDAVP)

desmopressin

polyuric conditions

bleeding disorders


Input: Propafenone's distribution, clearance, and structural similarity to propranolol contribute to its central nervous system effects.

contribute

central nervous system effects

Propafenone

propranolol

Propafenone


Input: Risk of severe serotonin toxicity following co-administration of methylene blue and serotonin reuptake inhibitors: an update on a case report of post-operative delirium.

following

serotonin toxicity

post-operative delirium

co-administration of methylene blue and serotonin reuptake inhibitors

methylene blue

serotonin reuptake inhibitors

methylene blue

serotonin reuptake inhibitors


Input: Cyclophosphamide-induced cardiotoxicity occurred, even though the patient had both shown normal cardiac function before high-dose chemotherapy and had received a lower dose of cyclophosphamide.

induced

the patient had both shown normal cardiac function

cardiotoxicity

Cyclophosphamide

high-dose chemotherapy and had received a lower dose of cyclophosphamide

Cyclophosphamide

lower dose


Input: A 64 year old woman with previous history of coronary stenting five days before was admitted in our institution for intracranial bleeding while receiving aspirin and clopidogrel.

receiving

A 64 year old woman with previous history of coronary stenting

64 year old

woman

intracranial bleeding

five days before

aspirin and clopidogrel

clopidogrel

aspirin

coronary stenting

five days

aspirin

clopidogrel


Input: METHODS: A case is presented of a 45-year-old woman on prolonged gemcitabine treatment for ovarian cancer who developed HUS and recovered after drug discontinuation.

developed

a 45-year-old woman

woman

HUS

prolonged gemcitabine treatment

gemcitabine

prolonged

ovarian cancer


Input: A more serious development of adrenal insufficiency may occur upon the improper replacement of systemic steroids.

replacement

development of adrenal insufficiency

systemic steroids

steroids


Input: We describe a case of pneumonitis following local administration of methotrexate for nonsurgical termination of an ectopic pregnancy.

following

a case

pneumonitis

local administration of methotrexate

methotrexate

ectopic pregnancy


Input: There is currently no consensus on the best treatment for unresectable hyaline-vascular variant or for multicentric Castleman's disease (MCD), because none of the reported regimens have consistently produced complete response or durable remission in the majority of patients In the present study, we report on the use of 2-CdA (2-chloro-deoxyadenosine) in three patients, two of them with MCD and one with unresectable hyaline-vascular type disease.

use

one

one


Input: Carbamazepine-induced hyperammonemia.

induced

hyperammonemia

Carbamazepine

Carbamazepine


Input: Case 3: A 29-year-old female alcoholic complained of general fatigue and a slight fever after 1.5 years of abstinence with cyanamide treatment.

complained

A 29-year-old female alcoholic

female

general fatigue and a slight fever

after 1.5 years of abstinence with cyanamide

alcoholic

1.5 years

cyanamide


Input: Caution is, therefore, needed to prevent undesired accumulation of TCA that may lead to protracted Cushing's syndrome.

lead to

protracted Cushing's syndrome

TCA

TCA


Input: Unusual pigmentary changes associated with 5-fluorouracil therapy.

associated

Unusual pigmentary changes


Input: Syndrome of inappropriate antidiuretic hormone associated with vinorelbine therapy.

associated

Syndrome of inappropriate antidiuretic hormone

vinorelbine

vinorelbine


Input: The study showed a high incidence of adverse events when a higher than standard dose of the new lopinavir/ritonavir tablets was combined with rifampicin.

when

adverse events

higher than standard dose of the new lopinavir/ritonavir tablets was combined with rifampicin

higher than standard dose

rifampicin

lopinavir

ritonavir

ritonavir

lopinavir

rifampicin


Input: Onset of male gynaecomastia in a patient treated with sunitinib for metastatic renal cell carcinoma.

Onset

male

a patient

male

gynaecomastia

sunitinib for metastatic renal cell carcinoma

metastatic renal cell carcinoma

sunitinib


Input: Systemic disease, most commonly renal dysfunction, preceded all 30 reported cases of acyclovir neurotoxicity.

preceded

30 reported cases

Systemic disease, most commonly renal dysfunction

neurotoxicity

acyclovir

acyclovir


Input: Rifampicin-induced renal failure.

induced

renal failure

Rifampicin

Rifampicin


Input: A case of high-grade endometrial stromal sarcoma, confined into an intrauterine polypoid growth, in a woman with a history of breast cancer who was treated with adjuvant tamoxifen.

treated

A case of high-grade endometrial stromal sarcoma, confined into an intrauterine polypoid growth, in a woman with a history of breast cancer

woman

breast cancer

A

adjuvant tamoxifen

tamoxifen

high-grade endometrial stromal sarcoma, confined into an intrauterine polypoid growth


Input: After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.

After

the patient

increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness

therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions

diabetic coma

insulin

preservative cresol

electrolyte solutions

electrolyte solutions

preservative cresol

insulin


Input: A case of severe aplastic anemia secondary to treatment with lenalidomide for multiple myeloma.

secondary

A case

severe aplastic anemia

lenalidomide for multiple myeloma

multiple myeloma

lenalidomide


Input: Seven weeks after the initiation of inhaled fluticasone, she developed vaginal candidiasis and was prescribed fluconazole 100 mg/day, a CYP3A4 inhibitor.

developed

vaginal candidiasis

Seven weeks after the initiation of inhaled fluticasone

inhaled

fluticasone

Seven weeks


Input: The introduction of para-aminosalicylic acid (PAS) led to hypoglycaemic coma.

led to

hypoglycaemic coma

The introduction of para-aminosalicylic acid (PAS)

para-aminosalicylic acid


Input: The risk of developing sAML is estimated to be between 1% and 5%, 2-20 years after exposure to etoposide but may also be related to cumulative drug doses, treatment schedules, host factors and co-administration of other antineoplastic agents.

after

sAML

2-20 years after exposure to etoposide

etoposide

2-20 years


Input: An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.

with

a woman

woman

An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation

methimazole and propranolol

methimazole

propranolol

hyperthyroidism

methimazole

propranolol


Input: Ethambutol is frequently used in the treatment of tuberculosis, and, although optic neuropathies have been reported with the use of ethambutol, this adverse side effect has been considered to be rare and generally reversible with discontinuation of the medication.

used

Ethambutol

tuberculosis

Ethambutol


Input: Skin manifestations of a case of phenylbutazone-induced serum sickness-like reactions.

induced

serum sickness-like reactions

phenylbutazone

phenylbutazone


Input: Development of Crohn's disease in a patient with multiple sclerosis treated with copaxone.

Development

a patient with multiple sclerosis

Crohn's disease

copaxone

multiple sclerosis

copaxone


Input: Aliskiren-associated acute renal failure with hyperkalemia.

associated

acute renal failure

Aliskiren

Aliskiren


Input: Fever caused by the use of furosemide was proved; the fever resolved after discontinuation of this medication and recurred after its reintroduction.

caused

Fever

furosemide

furosemide


Input: The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.

accelerate

HIV disease

MTX

methotrexate (MTX)

MTX


Input: Pharmacokinetics of dapsone gel, 5% for the treatment of acne vulgaris.

treatment

dapsone gel, 5%

dapsone

acne vulgaris


Input: To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.

associated

pediatric patients

pediatric

irreversible renal failure and rickets

TDF

TDF


Input: In particular, this adverse effect has never been described with mefloquine (Lariam).

described

adverse effect

mefloquine (Lariam)

mefloquine


Input: A potential role for renal and hepatic impairment in the observed protracted course of amiodarone-induced thyrotoxicosis is suggested.

induced

thyrotoxicosis

amiodarone

amiodarone


Input: The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.

associated

The patient

a painful hand ulcer

new skin cancers

hydroxyurea

skin lesions

hydroxyurea


Input: Potential aripiprazole-mediated extrapyramidal symptoms in an adult with developmental disabilities.

mediated

an adult with developmental disabilities

adult

extrapyramidal symptoms

aripiprazole

aripiprazole

developmental disabilities


Input: We describe a patient with extranodal non-Hodgkin lymphoma who developed systemic candidiasis after treatment with a cyclophosphamide-based chemotherapy regimen.

treatment

a patient with extranodal non-Hodgkin lymphoma

systemic candidiasis

a cyclophosphamide-based chemotherapy regimen.

extranodal non-Hodgkin lymphoma

cyclophosphamide-based chemotherapy


Input: We describe the first case of de novo asthma following treatment with the angiotensin converting enzyme (ACE) inhibitor captopril.

treatment with

de novo asthma

the angiotensin converting enzyme (ACE) inhibitor captopril

captopril


Input: A 53-year-old male, without any prior history of psychosis, developed schizophrenia 4 days after starting low-dose bromocriptine therapy for a macroprolactinoma.

developed

A 53-year-old male, without any prior history of psychosis

macroprolactinoma

male

schizophrenia

4 days after starting low-dose bromocriptine therapy

bromocriptine

macroprolactinoma

4 days after

low-dose


Input: Six days after taking erlotinib, a chest radiograph showed rapid progression of reticular infiltration in both lung fields.

after

rapid progression of reticular infiltration in both lung fields

Six days

erlotinib

Six days

erlotinib


Input: Because of suspected drug-induced seizures, both antidepressants were stopped.

stopped.

seizures

antidepressants

antidepressants


Input: Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.

associated

serotonin syndrome

co-administration of citalopram and fentanyl

citalopram

fentanyl

citalopram

fentanyl


Input: We report a case of a patient with rheumatoid arthritis treated with low-dose methotrexate (15 mg/week) who developed infection with both M. tuberculosis and M. chelonae after the revision of a prosthetic hip.

developed

patient with rheumatoid arthritis

infection with both M. tuberculosis and M. chelonae

low-dose methotrexate (15 mg/week)

15 mg/week

methotrexate

rheumatoid arthritis


Input: Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy.

undergoing

two patients

two

Thrombotic microangiopathy with renal failure

gemcitabine chemotherapy

gemcitabine

chemotherapy


Input: Despite the known pulmonary side effects of nitrofurantoin, there is no report of this toxicity occurring in pregnant patients.

of

pulmonary side effects

nitrofurantoin

nitrofurantoin


Input: However, several case reports have suggested that clozapine could also cause TD.

cause

TD

clozapine

clozapine


Input: A case is presented in which a 68-year-old man became delirious after being withdrawn from a low dosage of alprazolam.

after

68-year-old man

man

delirious

withdrawn from a low dosage of alprazolam

alprazolam

low dosage


Input: However, re-initiation of sunitinib treatment was followed by bilateral breast enlargement again.

followed

bilateral breast enlargement

sunitinib

sunitinib


Input: BACKGROUND: Hydroxyurea is a cytostatic agent used to treat myeloproliferative disorders and long-term treatment is associated with mucocutaneous adverse events and nail hyperpigmentation.

associated

mucocutaneous adverse events and nail hyperpigmentation

Hydroxyurea is a cytostatic agent

Hydroxyurea

myeloproliferative disorders


Input: Captopril-induced acute reversible renal failure.

induced

acute reversible renal failure

Captopril

Captopril


Input: Hence, hyperthyroidism induced by IFN-alpha could correspond to the first phase of silent thyroiditis, to Graves' disease or to the succession of both.

induced

hyperthyroidism

IFN-alpha

IFN-alpha


Input: The epivodes of NMS occured under treatment with clozapine, risperidone, and amisulpride.

occured

NMS

clozapine, risperidone, and amisulpride

clozapine

risperidone

amisulpride

clozapine

risperidone

amisulpride


Input: During the first days of arsenic trioxide treatment a rapid decrease in the D-dimers was seen (normal values reached until day 7), together with a slight decrease in peripheral blood leukocytes.

During

a rapid decrease in the D-dimers was seen (normal values reached until day 7), together with a slight decrease in peripheral blood leukocytes

the first days of arsenic trioxide treatment

arsenic trioxide

the first days


Input: In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis.

for

Graves' disease

Graves' disease

IFN-alpha

chronic viral C hepatitis

IFN-alpha


Input: We postulate that gastritis caused by dexamethasone, mucositis caused by doxorubicin, and the unique anatomic nature of a Meckel diverticulum may have contributed to this extremely unlikely and previously unreported event.

caused

gastritis

dexamethasone

dexamethasone


Input: Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.

cause

patients with Crohn's disease

hypersensitivity pneumonitis

Mesalamine

Crohn's disease

Mesalamine


Input: We present a case in which dipyridamole induced high-grade atrioventricular (AV) block that responded promptly to intravenous aminophylline but not to atropine.

induced

high-grade atrioventricular (AV) block

dipyridamole

dipyridamole


Input: This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.

developed

an autopsy case of a 78-year-old male

prostatic cancer

male

multiple nodules in the liver

phosphate diethylstilbestrol (PDES)

prostatic cancer

phosphate diethylstilbestrol


Input: Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.

occurred

one patient

one

Fracture of the femoral neck

PSL therapy

PSL


Input: This panic anxiety was not relieved by taking etizolam and flunitrazepam again, but subsided rapidly by the re-administration of mianserin 30 mg/day, and because of that the depressive symptom also disappeared.

subsided

because of that the depressive symptom also disappeared

etizolam and flunitrazepam

mianserin 30 mg/day

panic anxiety

depressive symptom

flunitrazepam

etizolam

mianserin

30 mg/day

etizolam

flunitrazepam

mianserin


Input: When co-trimoxazole was stopped the red cell aplasia resolved.

stopped

red cell aplasia resolved

co-trimoxazole

co-trimoxazole


Input: Interaction of sildenafil and indinavir when co-administered to HIV-positive patients.

co-administered

HIV-positive patients

Interaction of sildenafil and indinavir

HIV-positive

sildenafil

indinavir

sildenafil

indinavir


Input: Cerebral and ocular toxicity induced by desferrioxamine.

induced

Cerebral and ocular toxicity

desferrioxamine

desferrioxamine


Input: A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.

while

A patient

papilloedema and hepatic dysfunction

perhexiline maleate

perhexiline maleate


Input: We describe a case of subcutaneous metastasis along the needle track after percutaneous ethanol injection (PEI) for treatment of hepatocellular carcinoma.

after

a case

subcutaneous metastasis

percutaneous ethanol injection (PEI)

ethanol

injection

hepatocellular carcinoma


Input: He developed episodic movements possibly consistent with EPS secondary to aripiprazole usage.

developed

episodic movements possibly consistent with EPS

secondary to aripiprazole usage

aripiprazole