Input: Recently, it has been reported that terfenadine and astemizole, which have antiallergic actions similar to those of oxatomide, show side effects on the cardiovascular system, such as QT prolongation, ventricular arrhythmia and cardiac arrest.

show

side effects on the cardiovascular system, such as QT prolongation, ventricular arrhythmia and cardiac arrest

terfenadine and astemizole

terfenadine

astemizole

terfenadine

astemizole


Input: We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d-penicillamine 125-500 mg daily.

following

3 patients

acute generalized dystonia and akinetic rigid syndrome

d-penicillamine 125-500 mg daily

d-penicillamine

125-500 mg daily


Input: Priapism associated with olanzapine.

associated

Priapism

olanzapine

olanzapine


Input: Thus, an immunological mechanism might be involved in the mechanism of pirmenol-induced QT prolongation and T wave inversion on the electrocardiogram.

induced

QT prolongation and T wave inversion

pirmenol

pirmenol


Input: Five months after initiating mirtazapine therapy, she developed symptomatic hyponatremia.

developed

she

she

symptomatic hyponatremia

Five months after initiating mirtazapine

Five months

mirtazapine


Input: Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.

cause

babies

babies

apnea, hypotension, and bradycardia

Intravenous verapamil

Intravenous

verapamil


Input: The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNalpha.

reported

two cases

two

The renal biopsy showed focal segmental glomerulosclerosis

IFNalpha

CML

IFNalpha


Input: Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.

reported

neurologic toxic effects

Sulindac (Clinoril)

Sulindac


Input: The second patient was a 32-year-old woman with HIV, anxiety disorder, and a history of intravenous drug abuse who developed increased sedation and mental confusion when an atazanavir-ritonavir-based antiretroviral regimen was added to her stable antianxiety drug regimen, which included quetiapine.

developed

a 32-year-old woman with HIV, anxiety disorder, and a history of intravenous drug abuse

woman

intravenous drug abuse

increased sedation and mental confusion

atazanavir-ritonavir-based antiretroviral regimen was added to her stable antianxiety drug regimen, which included quetiapine

quetiapine

atazanavir

ritonavir

HIV

anxiety disorder

ritonavir

atazanavir

quetiapine


Input: Fulminant hepatitis associated with disulfiram.

associated

Fulminant hepatitis

disulfiram

disulfiram


Input: Anhedonic ejaculation with desipramine.

with

Anhedonic ejaculation

desipramine

desipramine


Input: Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports.

induced

four patient

Serotonin syndrome

phenelzine to venlafaxine

phenelzine

venlafaxine


Input: Lower extremity arterial thrombosis following sonographically guided thrombin injection of a femoral pseudoaneurysm.

following

Lower extremity arterial thrombosis

thrombin injection of a femoral pseudoaneurysm

thrombin

injection

femoral pseudoaneurysm


Input: A severe form of exophthalmos resulting from lithium therapy has not been described in the literature.

resulting

exophthalmos

lithium

lithium


Input: No cases of renal acidosis, and only one case of nephrogenic diabetes insipidus, has been previously reported as a complication of foscarnet treatment.

reported

nephrogenic diabetes insipidus

foscarnet treatment

foscarnet


Input: Cough induced by quinapril with resolution after changing to fosinopril.

resolution

Cough

fosinopril

quinapril

fosinopril


Input: INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.

cause

interstitial lung disease (ILD)

gefitinib

non-small-cell lung cancer

gefitinib


Input: We report a case in which a potential drug interaction resulted in elevated phenytoin levels after initiation of erlotinib therapy in a patient who was receiving phenytoin.

resulted in

a patient

elevated phenytoin levels

a potential drug interaction

initiation of erlotinib therapy

receiving phenytoin

phenytoin

erlotinib

erlotinib

phenytoin


Input: Anastrozole-associated sclerosing glomerulonephritis in a patient with breast cancer.

associated

a patient with breast cancer.

sclerosing glomerulonephritis

Anastrozole

Anastrozole

breast cancer


Input: BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.

associated

cases

hemolytic-uremic syndrome (HUS)

renal toxicity

gemcitabine

gemcitabine


Input: Recurrent palmar-plantar erythrodysaesthesia following high-dose cytarabine treatment for acute lymphoblastic leukemia.

treatment

palmar-plantar erythrodysaesthesia

high-dose cytarabine

cytarabine

high-dose

acute lymphoblastic leukemia


Input: CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications.

risk

ischemic skin complications

Peripheral administration of low-dose vasopressin

septic shock

vasopressin

low-dose

Peripheral administration


Input: Many types of medicaments can cause akathisia as an adverse event of their use and they include: antipsychotics, antidepressants, antiemetics, antihistamines, and psychoactive substances.

adverse event

akathisia

antipsychotics, antidepressants, antiemetics, antihistamines, and psychoactive substances

antipsychotics

antidepressants

antiemetics

antihistamines

psychoactive substances.

antipsychotics

antidepressants

antiemetics

antihistamines

psychoactive substances.


Input: We report the case of a 60-year-old woman who developed erythema and erosions in the axilla and groin while on PLD for breast cancer.

developed

a 60-year-old woman

breast cancer

woman

erythema

erosions in the axilla and groin

PLD

PLD

breast cancer


Input: Serotonin syndrome has been reported with administration of linezolid and serotonin reuptake inhibitors.

reported with

Serotonin syndrome

administration of linezolid and serotonin reuptake inhibitors

linezolid

serotonin reuptake inhibitors

linezolid

serotonin reuptake inhibitors


Input: We suggest that the treatment of hypoglycaemia with 50% solution of dextrose is associated with a significant risk factor in those diabetic individuals who are either allergic or are receiving beta-adrenoreceptor blocking drugs.

associated

diabetic individuals who are either allergic or are receiving beta-adrenoreceptor blocking drugs

diabetic

a significant risk factor

50% solution of dextrose

hypoglycaemia

dextrose

50% solution


Input: A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.

exacerbation

preexisting maladaptive behavior

preexisting maladaptive behavior

exacerbation of a preexisting maladaptive behavior

phenobarbital

partially suppressed by chlorpromazine

phenobarbital

chlorpromazine

phenobarbital

chlorpromazine


Input: Colchicine-induced myopathy in a teenager with familial Mediterranean fever.

induced

a teenager with familial Mediterranean fever

teenager

myopathy

Colchicine

Mediterranean fever

Colchicine


Input: Levofloxacin-induced delirium with psychotic features.

induced

delirium with psychotic features

Levofloxacin

Levofloxacin


Input: Methemoglobinemia: an occupational hazard of phenylpropanolamine production.

production.

Methemoglobinemia

phenylpropanolamine

phenylpropanolamine


Input: Destructive thyrotoxicosis appeared 4-6 months after starting IFN-alpha, followed by Graves' hyperthyroidism within 8 to 11 months.

after

Destructive thyrotoxicosis

Graves' hyperthyroidism

IFN-alpha

IFN-alpha

4-6 months


Input: CASE SUMMARIES: In each case, the patients were treated over 5 years with lovastatin and developed rhabdomyolysis that coincided with the completion of a prescribed regimen of a newer macrolide antibiotic.

developed

patients

rhabdomyolysis

5 years with lovastatin

a newer macrolide antibiotic

5 years

lovastatin

macrolide antibiotic

lovastatin

macrolide antibiotic


Input: Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia.

associated

patient with acquired haemophilia

Thrombotic stroke

porcine factor VIII

porcine factor VIII

acquired haemophilia


Input: PURPOSE: The intravitreal application of triamcinolone acetonide as treatment of long-standing, therapy-resistant cystoid macular edema after penetrating keratoplasty is reported.

treatment

The intravitreal application of triamcinolone acetonide

intravitreal

triamcinolone acetonide

cystoid macular edema


Input: Patients receiving ciprofloxacin and digoxin should be monitored closely for the risk of digoxin toxicity.

the risk

Patients

digoxin toxicity

ciprofloxacin and digoxin

ciprofloxacin

digoxin

digoxin

ciprofloxacin


Input: To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.

due

pancytopenia

MMI

MMI


Input: The following is a report of 2 cases of rifampicin-induced renal insufficiency.

induced

renal insufficiency

rifampicin

rifampicin


Input: Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan.

attributed

marrow transplant patient

Fatal eosinophilia myalgia syndrome

total parenteral nutrition with a solution containing tryptophan

tryptophan

parenteral


Input: We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol.

developed

43-year-old man

man

bilateral optic neuropathy

ethambutol

ethambutol


Input: The patient described in this paper was a 78-year-old diabetic man who developed oral lesions of PV following institution of glibenclamide therapy.

following

The patient described in this paper was a 78-year-old diabetic man

man

oral lesions of PV

institution of glibenclamide

glibenclamide

diabetic


Input: Since elevated cortisol levels in Cushing's disease poses a threat for pancreatitis, there is a possibility that patients with Cushing's disease might be more prone to acute pancreatitis following propofol administration.

following

patients with Cushing's disease

acute pancreatitis

propofol

propofol

Cushing's disease


Input: Ticlopidine is an oral antiplatelet agent frequently utilized in the treatment of cerebrovascular disease and is rarely associated with severe bone marrow suppression, typically aplastic anemia.

associated

severe bone marrow suppression, typically aplastic anemia

Ticlopidine is an oral antiplatelet agent

cerebrovascular disease

Ticlopidine

oral


Input: Moxifloxacin and lomefloxacin are fluoroquinolone antibiotics used in treating urinary and respiratory tract infections.

treating

Moxifloxacin and lomefloxacin

fluoroquinolone antibiotics

Moxifloxacin

lomefloxacin

fluoroquinolone antibiotics

urinary and respiratory tract infections


Input: To our knowledge, this case report represents only the third description of laxative-induced TEN.

induced

TEN

laxative

laxative


Input: Prompted by the advent of potentially life-threatening neuromuscular symptoms following initiation of linezolid therapy in two patients receiving treatment with a serotonin reuptake inhibitor antidepressant, an evaluation was conducted to determine the incidence and characteristics of symptomatic serotonin toxicity among hospitalized patients receiving combined treatment with these medications.

following

two patients

two

life-threatening neuromuscular symptoms

linezolid

with a serotonin reuptake inhibitor antidepressant

serotonin reuptake inhibitor antidepressant

linezolid

linezolid

serotonin reuptake inhibitor antidepressant


Input: Celiac disease onset after pegylated interferon and ribavirin treatment of chronic hepatitis C.

onset

Celiac disease

pegylated interferon and ribavirin treatment of chronic hepatitis C.

pegylated interferon

ribavirin treatment

chronic hepatitis C.

pegylated interferon

ribavirin treatment


Input: Hyperkalaemia with renal tubular dysfunction by sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia in patients with lymphoid malignancy.

by

patients with lymphoid malignancy

lymphoid malignancy

Hyperkalaemia with renal tubular dysfunction

sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia

Pneumocystis carinii pneumonia

sulfamethoxazole-trimethoprim


Input: Following 7 days of tigecycline she developed severe abdominal pain and elevated pancreatic enzymes suggesting acute pancreatitis.

developed

she

abdominal pain and elevated pancreatic enzymes

7 days of tigecycline

7 days

tigecycline


Input: To treat hepatitis B, interferon alpha was administered until the proximal muscle weakness developed.

developed.

proximal muscle weakness

interferon alpha

hepatitis B

interferon alpha


Input: We report a case of the serotonin syndrome during treatment with lithium and venlafaxine, an antidepressant with a dual selective re-uptake inhibition mechanism, and review the literature for similar cases.

during

a case

serotonin syndrome

lithium and venlafaxine

lithium

venlafaxine

lithium

venlafaxine


Input: Supratherapeutic flecainide plasma concentrations may cause delirium.

cause

delirium

Supratherapeutic flecainide plasma concentrations

flecainide


Input: At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.

development

the patient

abnormally large mammary glands associated with pain and peri-areolar erythema

fifth cycle of sunitinib therapy

sunitinib

fifth cycle


Input: This is a case report of possible association of methylphenidate and enuresis in an 11-year-old boy with attention deficit hyperactivity disorder.

association

an 11-year-old boy with attention deficit hyperactivity disorder

boy

enuresis

methylphenidate

methylphenidate

attention deficit hyperactivity disorder


Input: This report describes a case of neuroleptic malignant syndrome due to risperidone in a child with Joubert syndrome.

due to

a child with Joubert syndrome

child

neuroleptic malignant syndrome

risperidone

Joubert syndrome

risperidone


Input: A 47-year-old HIV-infected man with dilated cardiomyopathy and prolonged QT syndrome with an automatic implantable cardiovascular defibrillator device was prescribed subcutaneous enfuvirtide 90 mg twice daily as part of his antiretroviral regimen and oral extended-release niacin 500 mg/day for a high-density lipoprotein level of 8 mg/dL. After 1 week of concomitant therapy, the patient began experiencing extreme redness, edema, and swelling at the injection site that corresponded with the flushing sensation due to niacin.

experiencing

A 47-year-old HIV-infected man with dilated cardiomyopathy and prolonged QT syndrome with an automatic implantable cardiovascular defibrillator device

dilated cardiomyopathy

prolonged QT syndrome

man

extreme redness, edema, and swelling at the injection site that corresponded with the flushing sensation due to niacin

subcutaneous enfuvirtide 90 mg twice daily as part of his antiretroviral regimen and oral extended-release niacin 500 mg/day for a high-density lipoprotein level of 8 mg/dL.

HIV-infected

90 mg

500 mg

twice daily

day

enfuvirtide

niacin

subcutaneous

oral

1 week

niacin

enfuvirtide


Input: Acute INH neurotoxicity was not suspected on the first admission; however, when readmitted 4 weeks later with another seizure, the diagnosis of acute INH neurotoxicity was made.

diagnosis

seizure

acute INH neurotoxicity

INH

INH


Input: Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.

induced

an elderly patient.

elderly

toxic epidermal necrolysis

Levofloxacin

Levofloxacin


Input: The incidence of 5-fluorouracil (5-FU)-related cardiotoxicity seems to be dosage and schedule dependent.

related

cardiotoxicity

dosage

schedule

5-fluorouracil (5-FU)


Input: Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.

induced

Torsades de Pointes

a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs

garenoxacin

disopyramide

cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs

garenoxacin

disopyramide

cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs


Input: Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature.

caused

Ataxia

propafenone

propafenone


Input: The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.

developed

The first patient

mild nitritoid symptoms and pain in a band-like distribution

gold sodium thiomalate (GSTM) injection

gold sodium thiomalate

injection


Input: A case is reported of an elderly woman who developed febrile agranulocytosis several weeks after commencing ticlopidine but who had a favorable outcome after cessation of that drug and treatment with filgastrim.

developed

an elderly woman

elderly

woman

febrile agranulocytosis

several weeks after commencing ticlopidine

several weeks

ticlopidine


Input: Two 65-year-old white men with coronary heart disease, given niacin therapy for dyslipidemia for 5 months, developed intense dental and gingival pain that was associated with increases in dose and that was relieved with discontinuance of niacin treatment.

developed

Two 65-year-old white men with coronary heart disease

coronary heart disease

Two

white

men

intense dental and gingival pain

niacin therapy for dyslipidemia for 5 months

increases in dose

dyslipidemia

niacin

increases in dose

5 months


Input: Two patients are described who developed testicular swelling and pain during treatment with desipramine.

during

Two patients

Two

testicular swelling and pain

desipramine

desipramine


Input: Metabolic balance studies and rechallenge with hydrochlorothiazide were undertaken to investigate the mechanism of the thiazide-induced hyponatremia.

induced

hyponatremia

thiazide

hydrochlorothiazide

thiazide


Input: Paradoxical pulmonary vasoconstriction induced by nitroglycerin in idiopathic pulmonary hypertension.

induced

Paradoxical pulmonary vasoconstriction

nitroglycerin

nitroglycerin

idiopathic pulmonary hypertension


Input: Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased.

after

complex visual hallucinations and altered mental status

zonisamide

zonisamide


Input: Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review.

related

case

angioneurotic edema

oxcarbazepine

oxcarbazepine


Input: Extra caution should be taken in using octreotide or its long-acting analog in patients otherwise predisposed to intrahepatic bile stasis.

predisposed

patients

intrahepatic bile stasis

octreotide or its long-acting analog

octreotide

long-acting analog


Input: BACKGROUND: Fluoxetine, a highly specific serotonin reuptake inhibitor, has been reported to cause sexual dysfunction in a minority of patients.

cause

minority of patients

sexual dysfunction

Fluoxetine

Fluoxetine


Input: We report a 45-year-old Chinese man with CML and chronic hepatitis B virus infection, on imatinib treatment, presenting with herpetic rash and acute liver failure.

presenting

a 45-year-old Chinese man with CML and chronic hepatitis B virus infection

Chinese

man

herpetic rash and acute liver failure

on imatinib treatment

imatinib

CML and chronic hepatitis B


Input: One patient had severe temporary weakness after an ampicillin sodium challenge.

after

One patient

One

temporary weakness

an ampicillin sodium challenge

ampicillin sodium


Input: Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation.

occurring

a chronic lymphocytic leukemia patient

Acute myeloid leukemia and lung cancer

fludarabine and autologous peripheral blood stem-cell transplantation

fludarabine

chronic lymphocytic leukemia


Input: Despite a very low complication rate, several severe arterial thrombotic events have been reported following thrombin injection of pseudoaneurysms.

following

arterial thrombotic

thrombin injection

thrombin

injection

pseudoaneurysms


Input: The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.

associated

suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism


Input: Exposure of the fetus to indomethacin by administration of the drug to the mother may cause many side effects, including premature closure of the ductus arteriosus.

side effects,

fetus

fetus

premature closure of the ductus arteriosus

indomethacin

indomethacin


Input: She was diagnosed with Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD) due to immunodeficiency caused by MTX administration.

due

She

She

Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD)

immunodeficiency caused by MTX administration

MTX


Input: Pulmonary hypertension during lithium therapy: clinical case study.

during

Pulmonary hypertension

lithium therapy

lithium


Input: CONCLUSIONS: Clinicians should be aware of this adverse reaction when facing similar complex neurologic symptoms in patients who are receiving the antibiotic treatment described here, especially vancomycin.

adverse reaction

patients

neurologic symptoms

vancomycin

vancomycin


Input: Corneal edema recurred when the administration of amantadine was resumed.

when

Corneal edema

the administration of amantadine was resumed

amantadine


Input: Vitamin K1 caused skin rash possibly because of the distribution and metabolism characteristic of the drug in this patient.

caused

skin rash

Vitamin K1

Vitamin K1


Input: Initial treatment with heparin was substituted with thrombolysis, which resulted in clinical improvement and dissolution of right heart thrombus but was followed by fatal intracerebral haemorrhage.

resulted

fatal intracerebral haemorrhage

thrombolysis

thrombolysis


Input: The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature.

effect

optic neuropathy

ethambutol

ethambutol


Input: A case of congestive heart failure in a child with Wilms' tumor treated Adriamycin is presented and discussed.

in

a child with Wilms' tumor

child

congestive heart failure

Adriamycin

Adriamycin

Wilms' tumor


Input: BACKGROUND: Hypersensitivity reactions to cyclosporine are rare.

to

Hypersensitivity reactions

cyclosporine

cyclosporine


Input: This is the first case of TMP-SMX-induced hypersensitivity syndrome associated with the reactivation of a latent viral infection.

induced

first case

hypersensitivity syndrome

reactivation of a latent viral infection

TMP-SMX

TMP

SMX

SMX

TMP


Input: In addition, single-agent weekly AUC2-carboplatin appeared to be inactive by response criteria in a homogenously defined population of PROC.

inactive

a homogenously defined population of PROC

single-agent weekly AUC2-carboplatin

PROC

weekly


Input: CONCLUSIONS: Intrathecal baclofen can impair sexual function and ejaculation in some patients.

impair

some patients

impair sexual function and ejaculation

Intrathecal baclofen

Intrathecal

baclofen


Input: A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care.

induced

A case

tonic-clonic seizures

clozapine

clozapine


Input: Serum sickness consists of a systemic reaction resulting from the formation of soluble circulating immunocomplexes after the introduction of a foreign substance into the body We studied a 38-year-old woman diagnosed with anxiety, depression and right sacroileitis who was treated with phenylbutazone, ranitidine, clomipramine and levomepromazine.

treated

a 38-year-old woman diagnosed with anxiety, depression and right sacroileitis

woman

phenylbutazone, ranitidine, clomipramine and levomepromazine

phenylbutazone

clomipramine

levomepromazine

ranitidine

anxiety, depression and right sacroileitis

levomepromazine

clomipramine

ranitidine

phenylbutazone


Input: The symptomatology of 18 other paediatric cases of naphthylimidazoline exposure reported to the Belgian National Poison Centre, is also discussed.

symptomatology

18 other paediatric cases

paediatric

naphthylimidazoline exposure

naphthylimidazoline

naphthylimidazoline


Input: Anterior spinal artery syndrome--a complication of cervical intrathecal phenol injection.

complication

Anterior spinal artery syndrome

cervical intrathecal phenol injection

phenol

injection


Input: Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.

developed.

swelling of the face and legs and pruritus

phenytoin 1 g i.v.

a tonic-clonic seizure

phenytoin

1 g

i.v.


Input: To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-beta therapy for the malignant melanoma.

associated

histological abnormalities of the glomerulus

postoperative IFN-beta therapy

IFN-beta

malignant melanoma


Input: Protease inhibitor-induced carbamazepine toxicity.

induced

carbamazepine toxicity

Protease inhibitor

Protease inhibitor


Input: This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.

receiving

a patient

bilateral avascular necrosis of the femoral heads

'standard' doses of dexamethasone

'standard' doses

dexamethasone


Input: He recovered successfully after treatment with very high doses of corticosteroids and azathioprine.

recovered

He

He

very high doses of corticosteroids and azathioprine

very high doses

corticosteroids

azathioprine

corticosteroids

azathioprine


Input: Marked hyperkalemia was observed during and immediately after an infusion of arginine monohydrochloride in two patients with severe hepatic disease and moderate renal insufficiency.

observed

two patients with severe hepatic disease and moderate renal insufficiency

two

moderate renal insufficiency

Marked hyperkalemia

during and immediately after an infusion of arginine monohydrochloride

arginine monohydrochloride

infusion

immediately

hepatic disease


Input: Finally, reserpine toxicity, in particular central nervous system (CNS) disturbances, was reported more frequently in patients also receiving barbiturates, suggesting additive CNS effects.

reported

reserpine toxicity, in particular central nervous system (CNS) disturbances

additive CNS effects

reserpine

also receiving barbiturates,

barbiturates

reserpine

barbiturates

reserpine


Input: Patients receiving amifostine who develop only fever should be evaluated for an adverse drug reaction, as well as for sepsis and fevers of neutropenia, and it may be necessary to discontinue the drug.

develop

fever

sepsis and fevers of neutropenia

amifostine

amifostine


Input: Clinical signs of hypermagnesemia are an uncommon complication following oral administration of magnesium sulfate.

complication

hypermagnesemia

oral administration of magnesium sulfate

magnesium sulfate

oral


Input: Markedly increased pigmementation of skin immediately overlying veins used for multiple 5-fluorouracil infusions was noted.

noted.

Markedly increased pigmementation of skin immediately overlying veins

multiple 5-fluorouracil infusions

infusions


Input: Severe hepatitis caused by cyproterone acetate.

caused

Severe hepatitis

cyproterone acetate

cyproterone acetate


Input: Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature.

associated

three patients

three

Erythema multiforme

phenytoin and cranial radiation therapy

phenytoin


Input: Chloroquine has been used for many decades in the prophylaxis and treatment of malaria.

of

prophylaxis and treatment

Chloroquine

Chloroquine

malaria


Input: Before ICU admission, the patient had suffered from painful mucositis causing severe dysphagia and bleeding, which was thought to be the result of chemotherapy.

result

the patient had suffered from painful mucositis

mucositis

severe dysphagia and bleeding

chemotherapy

chemotherapy


Input: We report the case of a patient with the acquired immunodeficiency syndrome treated with rifampicin who had a 'normal' screening test for adrenal insufficiency, yet had clinical evidence of adrenal failure.

had

a patient with the acquired immunodeficiency syndrome

adrenal failure

rifampicin

rifampicin

acquired immunodeficiency syndrome


Input: We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.

produce

occasional patients

transient brain stem or neuromuscular dysfunction with eye movement abnormality

cyclosporin

together with ganciclovir

ganciclovir

cyclosporin

cyclosporin

ganciclovir


Input: Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.

resulted

Three patients

Three

'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment)

cytotoxic treatment, including high dose methotrexate with folinic acid rescue

tumour

cytotoxic

methotrexate

folinic acid rescue

high dose

folinic acid rescue

methotrexate

cytotoxic


Input: Methylene blue-associated serotonin toxicity has been described before but usually as mild toxicity.

associated

serotonin toxicity

Methylene blue

Methylene blue


Input: The second was an 82-year-old man receiving ticlopidine for 2 years when, during a febrile episode, he was found neutropenic with marrow aplasia.

found

82-year-old man

man

neutropenic with marrow aplasia.

receiving ticlopidine for 2 years

2 years

ticlopidine


Input: INTRODUCTION: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative.

induced

patients on antiretroviral treatment

hyperlactatemia

stavudine

stavudine


Input: We report a case of pediatric bupropion ingestion resulting in multiple seizures.

resulting

pediatric

pediatric

multiple seizures

bupropion ingestion

bupropion

ingestion


Input: The co-administration of SSRIs and fentanyl may precipitate serotonin toxicity.

precipitate

serotonin toxicity

co-administration of SSRIs and fentanyl

SSRIs

fentanyl

SSRIs

fentanyl


Input: Three days after intravitreal injection of bevacizumab, acute ocular ischemic syndrome occurred.

occurred.

acute ocular ischemic syndrome

Three days after intravitreal injection of bevacizumab

bevacizumab

intravitreal injection

Three days


Input: After addition of lopinavir/ritonavir, eight volunteers suffered from both nausea and vomiting, one from nausea only, and one from vomiting only.

After

eight volunteers

eight

nausea and vomiting

lopinavir/ritonavir

lopinavir

ritonavir

lopinavir

ritonavir


Input: Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common.

cause

irritation of the skin

Calcipotriol

Calcipotriol


Input: After discontinuation of danazol the diabetes completely resolved.

resolved.

discontinuation of danazol

diabetes

danazol


Input: We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.

development

woman

woman

ischemic colitis

tegaserod

tegaserod


Input: We presented the case of a patient who developed a cutaneous reaction induced by captopril with positive patch test.

induced

a patient

cutaneous reaction

captopril

captopril


Input: Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.

attributed

Three of these patients

Three

convulsions

imipenem/cilastatin

imipenem

cilastatin

imipenem

cilastatin


Input: This latest (third) report suggests that the safety profile should be reexamined and at least raises the question of potential renal toxicity of interferons in MS.

raises

potential renal toxicity

interferons

interferons

MS.


Input: Co-trimoxazole red cell aplasia in leukaemia.

in

red cell aplasia

Co-trimoxazole

leukaemia

Co-trimoxazole


Input: Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.

occurrence

MPGN

Interferon-alpha (IFN-alpha)

Interferon-alpha (IFN-alpha)


Input: Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.

after

Toxic epidermal necrolysis

high-dose cytosine arabinoside

cytosine arabinoside


Input: We describe 3 elderly patients with moderate to severe ataxia that occurred while they were taking propafenone.

occurred

3 elderly patients

elderly

moderate to severe ataxia

taking propafenone

propafenone


Input: Gestational diabetes was no less severe (degree of hyperglycaemia, need for insulin therapy) when associated with norethisterone.

associated

Gestational diabetes

norethisterone

norethisterone


Input: However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.

emerging

diabetes mellitus and impaired glucose tolerance

norethisterone

norethisterone


Input: Because the cerebellar toxicity may be worsened by continuation of therapy after initial onset of symptoms, prompt termination of HDARAC is recommended.

of

cerebellar toxicity

HDARAC

HDARAC


Input: We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus.

after

a girl with juvenile systemic lupus erythematosus

girl

ulcerative proctitis

ibuprofen treatment

ibuprofen

juvenile systemic lupus erythematosus


Input: Clinicians should include phenolphthalein in their list of possible causes of drug-induced TEN.

induced

TEN

phenolphthalein

phenolphthalein


Input: Methotrexate-induced diffuse interstitial pulmonary fibrosis.

induced

diffuse interstitial pulmonary fibrosis

Methotrexate

Methotrexate


Input: Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.

secondary

Abdominal wall ulceration and mucinosis

recombinant human interferon-beta-1b

recombinant human interferon-beta-1b


Input: Asthenozoospermia: possible association with long-term exposure to an anti-epileptic drug of carbamazepine.

association

Asthenozoospermia

long-term exposure to an anti-epileptic drug of carbamazepine

carbamazepine

long-term


Input: Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors.

triggered

Psoriasis

imiquimod

dermal plasmacytoid dendritic cell precursors

imiquimod


Input: A 52-year-old Black woman on phenytoin therapy for post-traumatic epilepsy developed transient hemiparesis contralateral to the injury.

developed

A 52-year-old Black woman

Black

woman

transient hemiparesis contralateral to the injury

phenytoin

post-traumatic epilepsy

phenytoin


Input: Use of the Naranjo probability scale determined the association between cephalosporin use and leukopenia to be probable.

use

leukopenia

cephalosporin

cephalosporin


Input: Sister chromatid exchanges (SCEs), a sensitive measure of chromosome damage, were counted in peripheral-blood lymphocytes from 10 patients with Behcet's syndrome receiving chlorambucil.

receiving

10 patients with Behcet's syndrome

chromosome damage

chlorambucil

Behcet's syndrome

chlorambucil


Input: Sarcoma complicating therapy with cyclophosphamide.

complicating

Sarcoma

cyclophosphamide

cyclophosphamide


Input: Clozapine induced polyserositis.

induced

polyserositis

Clozapine

Clozapine


Input: Fatal interstitial lung disease after erlotinib administration in a patient with radiation fibrosis.

after

a patient with radiation fibrosis

radiation fibrosis

interstitial lung disease

erlotinib

erlotinib


Input: The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.

reported

8 cardiac arrests

6 deaths

Halfan

when a higher dose than recommended was used

Halfan

mefloquine

a higher dose than recommended


Input: CONCLUSIONS: Fixed drug rash induced by methylphenidate is a possible but rare phenomenon.

induced

Fixed drug rash

methylphenidate

methylphenidate


Input: Special care should be taken when pulmonary symptoms appear in association with ticlopidine treatment.

appear

pulmonary symptoms

ticlopidine treatment

ticlopidine


Input: CONCLUSION: Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine.

using

agranulocytosis

quetiapine

quetiapine


Input: Acute renal failure is a rare complication following the administration of intravenous immunoglobulin (IVIG).

complication

Acute renal failure

intravenous immunoglobulin (IVIG)

intravenous

immunoglobulin


Input: We report four patients, three of whom first developed psoriasis and one who had an aggravation of the condition during treatment with interferon-alpha.

with

one

one

had an aggravation of the condition

interferon-alpha

interferon-alpha


Input: Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine.

followed

Reactivation of cytomegalovirus

corticosteroids and azathioprine

Wegener's granulomatosis

corticosteroids

azathioprine

corticosteroids

azathioprine


Input: We present a case of respiratory failure occurring in a woman at 16 weeks' gestation who was being treated with nitrofurantoin for a urinary tract infection.

occurring

a woman at 16 weeks' gestation

woman

16 weeks' gestation

respiratory failure

being treated with nitrofurantoin for a urinary tract infection

nitrofurantoin

urinary tract infection


Input: We describe a case of EGE manifested as an allergy to gemfibrozil.

manifested

a case of EGE

EGE

allergy

gemfibrozil

gemfibrozil


Input: RESULTS: At our institution, no children appeared with acute INH neurotoxicity in the period 1985 through 1990, whereas seven patients were treated from 1991 through 1993.

appeared with

children

children

neurotoxicity

INH

INH


Input: Two patients on long-term lithium therapy developed the nephrotic syndrome.

developed

Two patients

Two

nephrotic syndrome

long-term lithium therapy

lithium


Input: Acute psychosis associated with levetiracetam.

associated

Acute psychosis

levetiracetam

levetiracetam


Input: Hypoglycemia induced by long-acting somatostatin analogues in a patient with nonfunctional neuroendocrine tumor.

induced

a patient with nonfunctional neuroendocrine tumor

Hypoglycemia

long-acting somatostatin analogues

nonfunctional neuroendocrine tumor

long-acting somatostatin analogues


Input: CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin.

after

a patient

developed a DAT-positive hemolytic episode

a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin

oxaliplatin

a red cell

infusion

transfusion

17th cycle

oxaliplatin

a red cell


Input: Regression of thyrotoxic ophthalmopathy following lithium withdrawal.

Regression

lithium withdrawal

lithium

thyrotoxic ophthalmopathy


Input: Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.

induced

acute-onset myopia and angle closure glaucoma

topiramate

topiramate


Input: The clinical symptoms of gastric mucosa foveolar hyperplasia due to long-term PGE1 therapy simulate hypertrophic pyloric stenosis.

due

gastric mucosa foveolar hyperplasia

simulate hypertrophic pyloric stenosis

long-term PGE1 therapy

long-term


Input: Aggressive management of doxorubicin-induced cardiomyopathy associated with 'low' doses of doxorubicin.

induced

cardiomyopathy

doxorubicin

'low' doses

doxorubicin

'low' doses


Input: Generalized argyria after habitual use of AgNO3.

after

Generalized argyria

habitual use of AgNO3


Input: The authors report the first case of bucillamine-induced giant mammary hyperplasia.

induced

giant mammary hyperplasia

bucillamine

bucillamine


Input: Hydroxyurea (HU) and sodium phenylbutyrate (SPB) have been shown to increase fetal hemoglobin (Hb F) levels in patients with thalassemia intermedia.

increase

patients with thalassemia intermedia

hemoglobin (Hb F) levels

Hydroxyurea (HU) and sodium phenylbutyrate (SPB)

Hydroxyurea

sodium phenylbutyrate

thalassemia intermedia

Hydroxyurea

sodium phenylbutyrate


Input: We report a case of biopsy proven myositis whose symptoms began within 10 days of receiving leuprolide acetate therapy for prostate cancer.

symptoms began

a case

myositis

within 10 days of receiving leuprolide acetate therapy

leuprolide acetate

10 days

prostate cancer


Input: Venlafaxine-induced urinary incontinence resolved after switching to sertraline.

induced

urinary incontinence

Venlafaxine

Venlafaxine


Input: We report two cases of severe serotonin syndrome induced by the administration of cyclobenzaprine in postoperative patients already receiving another proserotoninergic drug (phenelzine in one case and duloxetine in the other).

induced

postoperative patients

postoperative

serotonin syndrome

cyclobenzaprine

duloxetine

duloxetine

cyclobenzaprine

duloxetine


Input: OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.

occurring

2 cases

serotonin syndrome with serious extrapyramidal movement disorders

metoclopramide was coadministered with sertraline or venlafaxine

metoclopramide

sertraline

venlafaxine

metoclopramide

sertraline

venlafaxine

metoclopramide


Input: We report a 31-year-old women with recurrent Hodgkin's lymphoma and unrecognized HMSN-1 who developed severe motor neuropathy 3 weeks after the first cycle of treatment including 2 mg of vincristine.

developed

a 31-year-old women with recurrent Hodgkin's lymphoma and unrecognized HMSN-1

women

unrecognized HMSN-1

severe motor neuropathy

3 weeks after the first cycle of treatment including 2 mg of vincristine

recurrent Hodgkin's lymphoma

3 weeks

2 mg

vincristine


Input: When the patient was treated again with fludarabine nine months later, the DAT became positive with anti-IgG and anti-C3d antiglobulins after the second course of treatment.

treated

the patient

the DAT became positive with anti-IgG and anti-C3d antiglobulins

fludarabine

second course of treatment

fludarabine

nine months later


Input: This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.

presented

patient

postoperative hypophosphatemia and hypocalcemic tetany

alendronate (Fosamax)

after bowel preparation with Fleet Phospho-Soda

alendronate

Fleet Phospho-Soda

alendronate

Fleet Phospho-Soda


Input: Acute dystonic reaction with low-dose pimozide.

with

Acute dystonic reaction

low-dose pimozide

low-dose

pimozide


Input: There are, however, case studies describing patients experiencing recurrences of tics following treatment with atomoxetine.

following

recurrences of tics

treatment with atomoxetine

atomoxetine


Input: Nicotinic acid-induced fulminant hepatic failure.

induced

fulminant hepatic failure

Nicotinic acid

Nicotinic acid


Input: Ketanserin in the treatment of protamine-induced pulmonary hypertension.

induced

pulmonary hypertension.

protamine

protamine


Input: We have safely used recombinant factor VIIa to treat bleeding in the immediate and long-term period following PCC-related MI.

treat

PCC-related MI

PCC-related MI

recombinant factor VIIa

bleeding

immediate and long-term period

recombinant factor VIIa


Input: Lithium and venlafaxine interaction: a case of serotonin syndrome.

case

serotonin syndrome

Lithium and venlafaxine interaction

Lithium

venlafaxine

Lithium

venlafaxine


Input: The seizures were suspected to be caused by a reduced concentration of VPA in the blood.

caused

seizures

reduced concentration of VPA in the blood

reduced concentration

VPA


Input: D-penicillamine induced crescentic glomerulonephritis: report and review of the literature.

induced

crescentic glomerulonephritis

D-penicillamine

D-penicillamine


Input: We offered several tentative explanations for this event, including an adverse interaction between paroxetine and other agent(s) used in the course of the anaesthesia.

between

adverse interaction

paroxetine and other agent(s)

paroxetine

anaesthesia

anaesthesia

paroxetine


Input: Neuroleptic malignant syndrome is an uncommon and potentially fatal idiosynchratic reaction of antipsychotic drugs, in which the clinical scenario encompass muscular rigidity, hyperthermia, autonomic dysfunction, altered consciousness, high creatinine phosphokinase levels, and leukocytosis.

reaction

Neuroleptic malignant syndrome

muscular rigidity, hyperthermia, autonomic dysfunction, altered consciousness, high creatinine phosphokinase levels, and leukocytosis

antipsychotic drugs

antipsychotic


Input: Indinavir-associated nephrolithiasis and chronic interstitial nephritis were the only possible causes identified in this patient.

associated

nephrolithiasis and chronic interstitial nephritis

Indinavir

Indinavir


Input: Gemcitabine is a chemotherapy agent that may cause unpredictable side effects.

cause

unpredictable side effects

Gemcitabine

Gemcitabine


Input: Albendazole-induced pseudomembranous colitis.

induced

pseudomembranous colitis

Albendazole

Albendazole


Input: Tuberculous uveitis after treatment with etanercept.

after

Tuberculous uveitis

etanercept

etanercept


Input: Salicylate-induced hepatotoxicity is reviewed.

induced

hepatotoxicity

Salicylate

Salicylate


Input: To describe a case of flecainide-induced delirium associated with a pharmacokinetic drug interaction with paroxetine.

induced

a case

delirium

flecainide

interaction with paroxetine

flecainide

paroxetine

paroxetine

flecainide


Input: We report on a patient who developed hypersensitivity pneumonitis during treatment with the beta-blocker, celiprolol.

developed

a patient

hypersensitivity pneumonitis

celiprolol

celiprolol


Input: dexmedetomidine is used to provide sedation for pediatric patients undergoing nonpainful radiological imaging studies.

used to

pediatric patients undergoing nonpainful radiological imaging studies

pediatric

provide sedation

dexmedetomidine

dexmedetomidine


Input: A 71-year-old woman developed serotonin syndrome while receiving treatment with moderate doses of lithium and venlafaxine for refractory depression.

developed

A 71-year-old woman

woman

serotonin syndrome

moderate doses of lithium and venlafaxine

refractory depression

moderate doses

lithium

venlafaxine

lithium

venlafaxine


Input: Four years after the beginning of IFN therapy, he acutely developed moderate hyperglycemia and severe ketonuria with positive islet cell antibody, and then 28 units/day of insulin injection was started.

developed

he

he

acutely developed moderate hyperglycemia and severe ketonuria with positive islet cell antibody

Four years after the beginning of IFN therapy

Four years after

IFN


Input: Tardive dyskinesia in 2 patients treated with ziprasidone.

in

2 patients

Tardive dyskinesia

ziprasidone

ziprasidone


Input: The mean time from starting MMF to the development of neutropenia was 4 months.

development

neutropenia

MMF

MMF


Input: Fulminant hepatic failure associated with bicalutamide.

associated

Fulminant hepatic failure

bicalutamide

bicalutamide


Input: A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer.

treatment

melanonychia and onycholysis

pemetrexed for lung cancer

lung cancer

pemetrexed


Input: Hypernatraemia induced by sodium polystyrene sulphonate (Kayexalate) in two extremely low birth weight newborns.

induced by

two extremely low birth weight newborns

two

newborns

Hypernatraemia

sodium polystyrene sulphonate (Kayexalate)

sodium polystyrene sulphonate (Kayexalate


Input: Hypoxia is a predisposing factor for premature ductal closure and often occurs after maternal indomethacin therapy.

after

premature ductal closure

maternal indomethacin therapy

indomethacin

maternal


Input: Severe histological osteomalacia developed in a woman with Crohn's disease 2 years after ileal resection and the start of cholestyramine therapy.

developed

a woman with Crohn's disease

woman

histological osteomalacia

2 years after ileal resection and the start of cholestyramine

cholestyramine

start

Crohn's disease


Input: Serotonin syndrome (SS) and neuroleptic malignant syndrome (NMS) are medical emergencies associated with psychotropic administration.

associated

Serotonin syndrome (SS) and neuroleptic malignant syndrome (NMS)

psychotropic administration

psychotropic


Input: Drug eruption caused by azathioprine: value of using the drug-induced lymphocytes stimulation test for diagnosis.

caused

Drug eruption

azathioprine

azathioprine


Input: Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.

occur

seizures

a complication of CBZ OD

CBZ OD


Input: The fluorine contained in niflumic acid induced a marked densification of trabecular bone in all 3 cases.

induced

all 3 cases

marked densification of trabecular bone

fluorine

niflumic acid

fluorine

niflumic acid


Input: A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency who developed a syringotropic hypersensitivity reaction after 9 months of therapy with infliximab and leflunomide is described.

developed

A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency

boy

alpha-1 antitrypsin deficiency

syringotropic hypersensitivity reaction

9 months of therapy with infliximab and leflunomide

refractory psoriatic arthritis

infliximab

leflunomide

9 months

infliximab

leflunomide


Input: Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.

in

cardiovascular collapse

severe flecainide overdose

flecainide

overdose


Input: A 53-year-old Caucasian male victim of suicide was suspected of overdose with sertraline and alprazolam after death-scene investigation.

with

53-year-old Caucasian male victim of suicide

Caucasian

male

overdose

sertraline and alprazolam

overdose

sertraline

alprazolam

sertraline

alprazolam


Input: Infliximab therapy may cause a lupus-like syndrome that is reversible upon discontinuing this agent.

cause

lupus-like syndrome

Infliximab therapy

Infliximab


Input: A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.

developed

A 7-year-old with congenital toxoplasmosis

fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis

pyrimethamine and sulfadiazine for reactivated chorioretinitis

reactivated chorioretinitis

congenital toxoplasmosis

pyrimethamine

sulfadiazine

pyrimethamine

sulfadiazine


Input: Pain management discussion forum: serious interaction among frequently used drugs for chronic pain.

among

serious interaction

frequently used drugs

chronic pain

frequently

drugs


Input: This kind of reaction is seldom mentioned as occurring during co-administration with tizanidine.

occurring

This kind of reaction

co-administration with tizanidine

tizanidine


Input: A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.

associated

37 (22%)

hepatic angiosarcoma

vinyl chloride, 'Thorotrast', and inorganic arsenic

vinyl chloride

Thorotrast

inorganic arsenic

vinyl chloride

Thorotrast

inorganic arsenic


Input: Progressive hypokalemia developed during phosphate treatment.

developed

Progressive hypokalemia

phosphate

phosphate


Input: A 69-year-old man developed pure red cell aplasia after taking fenoprofen for ten months.

developed

A 69-year-old man

man

pure red cell aplasia

taking fenoprofen for ten months

fenoprofen

ten months


Input: Introduction of etanercept was also clinically effective but followed by development of severe heart failure.

development

severe heart failure.

etanercept

etanercept


Input: Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma.

developing

Minimal change nephrotic syndrome

postoperative interferon-beta therapy for malignant melanoma

malignant melanoma

postoperative interferon-beta


Input: She was admitted following a fall and, after being given metoclopramide, developed movement disorder and a period of unresponsiveness.

developed

She was admitted following a fall

She

fall

movement disorder and a period of unresponsiveness

metoclopramide

metoclopramide


Input: We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.

treatment

a patient with neuropsychiatric SLE

transient panhypogammaglobulinaemia

prednisolone and cyclophosphamide

prednisolone

cyclophosphamide

neuropsychiatric SLE

prednisolone

cyclophosphamide


Input: Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.

induce

poorly nourished patients

poorly nourished

pellagra

Isoniazid

Isoniazid


Input: The authors suggest that in patients with corneal ulcers refractory to conventional treatment who are receiving colchicine, cessation of colchicine therapy should be considered.

receiving

patients with corneal ulcers

colchicine

colchicine

corneal ulcers


Input: After the patient discontinued rifampicin, the skin lesions cleared completely within 5 weeks without any systemic medication.

After

skin lesions cleared completely within 5 weeks

patient discontinued rifampicin

rifampicin

skin lesions

within 5 weeks


Input: Ziprasidone is an atypical antipsychotic drug that is believed to have a low propensity for inducing extrapyramidal symptoms, including tardive dyskinesia (TD).

inducing

extrapyramidal symptoms, including tardive dyskinesia (TD)

Ziprasidone

Ziprasidone

antipsychotic


Input: Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets.

following

Acute ischaemia of the leg

intra-arterial injection of dissolved flunitrazepam tablets

injection

flunitrazepam


Input: These findings suggest that prophylactic antibiotic use is unlikely to have a major impact on the recovery time from rocuronium-induced NMB with sugammadex reversal.

use

unlikely to have a major impact on the recovery time

prophylactic antibiotic

rocuronium-induced NMB with sugammadex reversal

prophylactic antibiotic


Input: Emphasis is given to the differentiation of diphenylhydantoin induced gingival hyperplasia from the angiomatous enlargement of the gingiva before any treatment is planned.

induced

gingival hyperplasia

the angiomatous enlargement of the gingiva

diphenylhydantoin

diphenylhydantoin


Input: Electro-oculography, electroretinography, visual evoked potentials, and multifocal electroretinography in patients with vigabatrin-attributed visual field constriction.

attributed

patients

visual field constriction

vigabatrin

vigabatrin


Input: CASE SUMMARIES: Two patients with stable hypothyroidism experienced symptoms of hypothyroidism with increased serum thyroid-stimulating hormone (TSH) concentrations after switching from 1 levothyroxine product to another.

after

Two patients with stable hypothyroidism

Two

hypothyroidism with increased serum thyroid-stimulating hormone

switching from 1 levothyroxine product to another

stable hypothyroidism

levothyroxine


Input: An objective causality assessment indicated a probable relationship between clotting abnormality and warfarin administration, although the degree of elevation of the INR was unusual in the light of the daily warfarin dose and duration of its exposure.

relationship

clotting abnormality

warfarin

warfarin


Input: The pathophysiological mechanisms remain unknown, although the drug could act through massive cytokines liberation after destruction of CD20 positive cells by rituximab.

act

massive cytokines liberation

destruction of CD20 positive cells

rituximab

rituximab


Input: The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.

adverse effects

hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia

sunitinib

sunitinib


Input: We report a 45-year-old psoriasis patient who developed eruptive mollusca contagiosa during an antipsoriatic treatment with efalizumab.

developed

45-year-old psoriasis patient

eruptive mollusca contagiosa

antipsoriatic treatment with efalizumab

psoriasis

efalizumab


Input: Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites.

complication

Skin necrosis

subcutaneous heparin therapy

heparin

subcutaneous


Input: Epsilon-aminocaproic acid and renal complications: case report and review of the literature.

complications:

renal complications

Epsilon-aminocaproic acid

Epsilon-aminocaproic acid


Input: Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.

implicated in

systemic and local side effects in patients with lupus

Ibuprofen

Ibuprofen


Input: CASE SUMMARIES: While conducting a protocol evaluating the efficacy of intraperitoneal cisplatin and hyperthermia in the treatment of recurrent ovarian cancer, 3 patients were noted to exhibit anaphylactoid reactions.

exhibit

3 patients

anaphylactoid reactions

intraperitoneal cisplatin and hyperthermia

cisplatin

intraperitoneal

recurrent ovarian cancer


Input: Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.

associated

Perinatal vasoconstrictive renal insufficiency

maternal nimesulide use

nimesulide


Input: Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.

developed

the patient

progressive ataxia related to carbamazepine toxicity

Protease inhibitors (ritonavir and saquinavir) were added to the treatment

carbamazepine

carbamazepine

Protease inhibitors

Protease inhibitors

carbamazepine


Input: The medical examiner's report indicated death caused by fluoxetine toxicity.

caused

death

fluoxetine toxicity

fluoxetine


Input: Hypertonic sodium bicarbonate is recognized as effective therapy for hypotension and arrhythmias.

effective

Hypertonic sodium bicarbonate

hypotension and arrhythmias

sodium bicarbonate


Input: Because toxicity may occur when flecainide is prescribed with paroxetine and other potent CYP2D6 inhibitors, flecainide plasma concentrations should be monitored closely with commencement of CYP2D6 inhibitors.

occur

toxicity

flecainide is prescribed with paroxetine and other potent CYP2D6 inhibitors

flecainide

paroxetine

flecainide

paroxetine


Input: Gentamicin-associated acute renal failure.

associated

acute renal failure

Gentamicin

Gentamicin


Input: Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.

induced

lung disorder

Sulfasalazine

Sulfasalazine


Input: Suspected ciprofloxacin-induced interstitial nephritis.

induced

interstitial nephritis

ciprofloxacin

ciprofloxacin


Input: Tegaserod-associated ischemic colitis.

associated

ischemic colitis

Tegaserod

Tegaserod


Input: Clinicians should be aware of the signs and symptoms of neurotoxicity during treatment, as well as predisposing factors that put patients receiving methotrexate at risk for neurotoxic effects.

risk

patients

neurotoxic effects

methotrexate

methotrexate


Input: We report the first case of chlorambucil-induced DRESS syndrome in a 70-year-old man recently diagnosed with chronic lymphocytic leukaemia.

induced

a 70-year-old man

man

DRESS syndrome

chlorambucil

chlorambucil

chronic lymphocytic leukaemia


Input: Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncope.

induced

syncope

oxymetazoline

oxymetazoline


Input: Marked elevation of serum creatine kinase associated with olanzapine therapy.

associated

Marked elevation of serum creatine kinase

olanzapine therapy

olanzapine


Input: After cessation of amantadine, the edema resolved, and the endothelial cell densities were <or=600/mm.

After

the edema resolved, and the endothelial cell densities were <or=600/mm

cessation of amantadine

amantadine


Input: DISCUSSION: Olanzapine, like other atypical antipsychotic drugs, may cause muscle injury with concomitant elevations of serum CK of muscle origin.

cause

muscle injury with concomitant elevations of serum CK of muscle origin

Olanzapine

atypical antipsychotic drugs

Olanzapine


Input: Study 202 was an open-label, add-on study in patients with partial or generalized epilepsy treated with valproic acid (VPA), carbamazepine (CBZ), phenytoin (PHT), or topiramate (TPM) as monotherapy.

treated

patients with partial or generalized epilepsy

valproic acid (VPA), carbamazepine (CBZ), phenytoin (PHT), or topiramate (TPM) as monotherapy

valproic acid

carbamazepine

phenytoin

topiramate

valproic acid

carbamazepine

phenytoin

topiramate


Input: Dual antiplatelet therapy with aspirin and a P2Y12 receptor antagonist following placement of coronary stents is critical to prevent stent thrombosis and subsequent myocardial infarction.

prevent

aspirin and a P2Y12 receptor antagonist following placement of coronary stents

stent thrombosis and subsequent myocardial infarction

aspirin

P2Y12 receptor antagonist

aspirin

P2Y12 receptor antagonist


Input: Organometals also compromise the limbic system and result in deficits in learning and memory.

result

compromise the limbic system

deficits in learning and memory

Organometals

Organometals


Input: Optic neuropathy associated with penicillamine therapy in a patient with rheumatoid arthritis.

associated

a patient with rheumatoid arthritis

Optic neuropathy

penicillamine

rheumatoid arthritis

penicillamine


Input: We present the first case of ovarian endometrioid carcinoma and endometriosis in a postmenopausal patient who was treated with tamoxifen for breast cancer.

treated with

postmenopausal patient

breast cancer.

ovarian endometrioid carcinoma and endometriosis

tamoxifen

tamoxifen

breast cancer


Input: There was a good correlation between the total dose of ACTH and the percentage decrease of brain parenchyma.

correlation

percentage decrease of brain parenchyma

total dose of ACTH

ACTH


Input: We noted that the delirium resembled serotonin toxicity and that the patient had been taking paroxetine until 2 days before surgery.

taking

delirium resembled serotonin toxicity

paroxetine until 2 days before surgery

paroxetine


Input: Primary central nervous system lymphoma in a patient treated with natalizumab.

treated

a patient

Primary central nervous system lymphoma

natalizumab

natalizumab


Input: We retrospectively reviewed the records of 7 pediatric oncology patients who received low-dose ketamine in conjunction with propofol for total intravenous anesthesia (TIVA) repeatedly for radiation therapy.

received

7 pediatric oncology patients

pediatric

low-dose ketamine in conjunction with propofol for total intravenous anesthesia (TIVA) repeatedly for radiation therapy

propofol

ketamine

low-dose

oncology

propofol

ketamine


Input: We presume the cause for multiple organ failure could be the result of drug-drug interaction, atorvastatin and verapamil, as verapamil is known to increase the serum concentration of atorvastatin significantly.

cause

multiple organ failure

interaction, atorvastatin and verapamil

atorvastatin

verapamil

atorvastatin

verapamil


Input: Hypersensitivity to zonisamide was confirmed by the skin patch test.

to

Hypersensitivity

zonisamide

zonisamide


Input: Pulmonary edema occurred 24 hours after intravenous ritodrine therapy and 10 hours after subcutaneous terbutaline therapy.

occurred

Pulmonary edema

24 hours after intravenous ritodrine therapy and 10 hours after subcutaneous terbutaline therapy

24 hours

10 hours

intravenous

subcutaneous

ritodrine

terbutaline

ritodrine

terbutaline


Input: Transient acute myopia resulting from isotretinoin (accutane) therapy.

resulting

Transient acute myopia

isotretinoin (accutane) therapy

isotretinoin


Input: We report a case of fatal fulminant hepatitis caused by the use of disulfiram in a man with previously normal hepatocellular function.

caused

a man

man

fatal fulminant hepatitis

disulfiram

disulfiram


Input: OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.

taking

two cases

patients

two

rhabdomyolysis

lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin

lovastatin

clarithromycin

azithromycin

clarithromycin

azithromycin


Input: Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.

association

two children with idiopathic neutropenia

two

children

Neutrophilic dermatoses

granulocyte colony-stimulating factor (G-CSF) therapy

idiopathic neutropenia

granulocyte colony-stimulating factor


Input: The zinc/o-cymen-5-ol system has direct antimicrobial effects and inhibits oral disease-related processes.

inhibits

antimicrobial effects

inhibits oral disease-related processes

zinc/o-cymen-5-ol system

zinc

zinc


Input: Paroxetine is a selective serotonin reuptake inhibitor possessing anti-depressant activity.

possessing

Paroxetine

anti-depressant activity

Paroxetine


Input: A case of polymyositis with dilated cardiomyopathy associated with interferon alpha treatment for hepatitis B.

associated

A case

polymyositis with dilated cardiomyopathy

interferon alpha

hepatitis B.

interferon alpha


Input: Phenytoin toxicity: an easily missed cause of cerebellar syndrome.

cause

cerebellar syndrome

Phenytoin

Phenytoin


Input: Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate.

treatment

an infant who developed pancreatitis caused by meglumine antimoniate

pancreatitis caused by meglumine antimoniate

infant

visceral leishmaniasis with allopurinol plus ketoconazole

visceral leishmaniasis

allopurinol

ketoconazole

ketoconazole

allopurinol


Input: Hepatotoxicity after high-dose methylprednisolone for demyelinating disease.

after

Hepatotoxicity

high-dose methylprednisolone

high-dose

methylprednisolone

demyelinating disease


Input: Interferon-alpha-induced focal segmental glomerulosclerosis in chronic myelogenous leukemia: a case report and review of the literature.

induced

focal segmental glomerulosclerosis in chronic myelogenous leukemia

Interferon-alpha

Interferon-alpha


Input: Prior reports have emphasized the tubular and interstitial lesions associated with intermittent or discontinuous rifampin therapy for tuberculosis.

associated

tubular and interstitial lesions

intermittent or discontinuous rifampin therapy

rifampin

tuberculosis


Input: Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.

following

an intracranial mass lesion

Transtentorial herniation

high-dose methotrexate

methotrexate

high-dose


Input: A case of prolonged suxamethonium apnoea successfully terminated by the infusion of a commercial preparation of serumcholinesterase is reported.

terminated

prolonged suxamethonium apnoea

the infusion of a commercial preparation of serumcholinesterase

suxamethonium

serumcholinesterase

infusion


Input: 53-year-old woman with a history of deep vein thrombosis and pulmonary embolism was receiving warfarin to prevent thromboembolic complications; her international normalized ratio (INR) had been stable for 1 month.

prevent

53-year-old woman with a history of deep vein thrombosis and pulmonary embolism

woman

warfarin

warfarin

deep vein thrombosis

pulmonary embolism

thromboembolic complications;


Input: OBJECTIVE: To describe a patient with asymptomatic bronchial asthma and hypertension who developed an acute asthma attack after receiving sustained-release verapamil.

after

a patient with asymptomatic bronchial asthma and hypertension

asymptomatic bronchial asthma

acute asthma attack

sustained-release verapamil

hypertension

sustained-release verapamil


Input: Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.

related

three cases

three

hepatotoxicity

benzarone

benzarone


Input: We report on a 56-year-old female who exhibited drug refractory paroxysmal atrial fibrillation, in which marked prolongation of the QT interval and T wave inversion on electrocardiogram was demonstrated reproducibly shortly after the administration of oral pirmenol therapy.

after

a 56-year-old female

female

drug refractory paroxysmal atrial fibrillation, in which marked prolongation of the QT interval and T wave inversion

pirmenol

pirmenol

oral


Input: Insulin-induced lipohypertrophy: report of a case with histopathology.

induced

lipohypertrophy

Insulin

Insulin


Input: OBJECTIVE: To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.

therapy

essential hypertension patients

indapamide

carbohydrate metabolism

hypertension

indapamide


Input: We describe a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) who paradoxically experienced worsening of Raynaud's phenomenon when using yohimbine for ED.

experienced

a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia)

CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia)

worsening of Raynaud's phenomenon

yohimbine

ED

yohimbine


Input: High-dose methotrexate-associated acute renal failure may be an avoidable complication.

associated

acute renal failure

High-dose methotrexate

High-dose

methotrexate


Input: Chronic myelogenous leukemia (CML), hepatitis C, and interferon alpha (IFNalpha) have all been associated with renal dysfunction.

associated

renal dysfunction

interferon alpha (IFNalpha)

interferon alpha


Input: CONCLUSIONS: Infectious endophthalmitis is a potential complication of intravitreal bevacizumab injection.

complication

Infectious endophthalmitis

intravitreal bevacizumab injection

bevacizumab

intravitreal

injection


Input: RESULTS: One case of recurrent primary peritoneal carcinoma previously treated with a carboplatin-based regimen, developed a platinum hypersensitivity.

developed

a platinum hypersensitivity

a carboplatin-based regimen

carboplatin

recurrent primary peritoneal carcinoma


Input: To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.

induced

rhabdomyolysis

lovastatin

associated with azithromycin and clarithromycin

lovastatin

azithromycin

clarithromycin

azithromycin

clarithromycin

lovastatin


Input: Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.

exhibited

three patients

medium and severe hypersensitivity reactions

carboplatin

carboplatin


Input: A case of sideroblastic anemia is presented in a patient with a left ventricular assist device drive-line infection who was receiving linezolid, an antibiotic used for serious infections with gram-positive organisms.

presented

a patient with a left ventricular assist device drive-line infection

left ventricular assist device drive-line infection

sideroblastic anemia

receiving linezolid

linezolid

serious infections with gram-positive organisms


Input: Development of nephrotic syndrome in a patient with acute myeloblastic leukemia after treatment with macrophage-colony-stimulating factor.

after

a patient with acute myeloblastic leukemia

nephrotic syndrome

macrophage-colony-stimulating factor

macrophage-colony-stimulating factor

acute myeloblastic leukemia


Input: In patients with a known access to INH, seizures should be considered to be caused by INH toxicity unless proved otherwise.

caused

seizures

INH

INH


Input: To our knowledge, this is the first case reported in the English literature of a generalized exanthem due to subcutaneous injection of enoxaparin.

due

the first case

generalized exanthem

subcutaneous injection of enoxaparin

subcutaneous injection

enoxaparin


Input: This case illustrates the potential decoupling of PSA response from disease status in flutamide withdrawal.

illustrates

potential decoupling of PSA response

flutamide withdrawal

flutamide


Input: Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active.

resolved,

her

arthritis

her

discontinuation of MTX

ascites

MTX


Input: Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.

administration

uremic patient

Colonic mucosal necrosis

calcium polystryrene sulfonate (Kalimate)

calcium polystryrene sulfonate

uremic


Input: Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.

secondary to

Intracranial hemorrhage and focal seizures

L-asparaginase

L-asparaginase


Input: A fatal poisoning case involving etizolam, phenobarbital, promethazine and chlorpromazine is presented.

involving

A fatal poisoning case

A fatal poisoning

etizolam, phenobarbital, promethazine and chlorpromazine

etizolam

phenobarbital

promethazine

chlorpromazine


Input: Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report.

induced

patient with metastatic pancreatic adenocarcinoma

hemolytic uremic syndrome

gemcitabine

gemcitabine

metastatic pancreatic adenocarcinoma


Input: Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine.

due

parvovirus B19 in a Crohn's disease patient

parvovirus B19

Leukopenia

azathioprine

Crohn's disease

azathioprine


Input: Fixed drug eruption of the scrotum due to methylphenidate.

due

Fixed drug eruption of the scrotum

methylphenidate

methylphenidate


Input: Cytarabine-induced cerebellar syndrome: case report and literature review.

induced

cerebellar syndrome

Cytarabine

Cytarabine


Input: We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer.

induced

a case

glaucoma

doxetaxel therapy for metastatic breast cancer

doxetaxel

metastatic breast cancer


Input: Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures.

induced and enhanced

developing into generalized seizures

Myoclonus

L-dopa

L-dopa


Input: During analysis of 28 patients receiving CAP with concomitant radiation (XRT) for pancreatic cancer (resected or locally advanced), two patients developed signs and symptoms consistent with peripheral neuropathy.

developed

two patients

two

peripheral neuropathy

CAP with concomitant radiation (XRT)

pancreatic cancer

CAP

concomitant radiation


Input: A liver biopsy in 2012 revealed marked fibrosis, leading the patient to start hepatitis C treatment with peginterferon alfa-2a, ribavirin and boceprevir.

treatment

fibrosis, leading the patient

peginterferon alfa-2a, ribavirin and boceprevir

fibrosis

peginterferon alfa-2a

ribavirin

boceprevir

ribavirin

boceprevir

peginterferon alfa-2a


Input: Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity.

adverse effects

neurotoxicity

CAP

CAP


Input: We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy.

over-anticoagulation

protracted diarrhea

warfarin

warfarin


Input: New oral therapies for type 2 diabetes mellitus:

for

oral therapies

type 2 diabetes mellitus

oral


Input: The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.

developed

two patients

two

lung disease

with histological features of bronchiolitis obliterans organising pneumonia (BOOP)

the use of nitrofurantoin

nitrofurantoin


Input: A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).

developed

A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions

woman

right bundle branch block +LPH

ventricular premature contractions

complete heart block (CHB)

disopyramide phosphate (Norpace)

disopyramide phosphate


Input: METHODS: In an institutional practice setting, two women, aged 25 and 45, developed acute myopia after starting topiramate for epilepsy.

developed

two women, aged 25 and 45

two

women

aged 25 and 45

acute myopia

topiramate

topiramate

epilepsy


Input: Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity.

related

subacute

neurotoxicity

methotrexate

methotrexate


Input: ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.

after

a patient

ARDS

severe pulmonary symptoms

infusion

rituximab

infusion

rituximab


Input: Seven of the eight cases of acute leukemia occurred in a series of 553 patients treated with Treosulfan for ovarian cancer in the period from 1970 to 1977 and followed closely for a total of 1159 patient-years up to February 1978.

occurred

Seven of the eight cases

eight

acute leukemia

Treosulfan

Treosulfan

ovarian cancer


Input: Desipramine-associated SIADH in an elderly woman: case report.

associated

an elderly woman

elderly

woman

SIADH

Desipramine

Desipramine


Input: Can propofol precipitate pancreatitis in patients with Cushing's syndrome?

precipitate

patients with Cushing's syndrome?

pancreatitis

propofol

propofol

Cushing's syndrome


Input: This case presents the possibility of anaphylaxis to topical 5-FU treatments and/or the interaction with angiotensin converting enzyme inhibitors.

to

anaphylaxis

angiotensin converting enzyme inhibitors

angiotensin converting enzyme inhibitors

angiotensin converting enzyme inhibitors


Input: After stopping indapamide, glucose tolerance impairing may be reversed.

stopping

indapamide, glucose tolerance impairing

glucose tolerance impairing

indapamide


Input: We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).

after

needle-track cutaneous seeding of hepatocellular carcinoma

sonographically guided percutaneous ethanol injection

injection

ethanol


Input: Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects.

occurrence

birth defects

Zidovudine

Zidovudine


Input: A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX).

developed

A patient with seropositive rheumatoid arthritis

ascites

taking weekly doses of methotrexate (MTX)

seropositive rheumatoid arthritis

weekly

methotrexate


Input: High incidence of adverse events in healthy volunteers receiving rifampicin and adjusted doses of lopinavir/ritonavir tablets.

receiving

healthy volunteers

High incidence of adverse events

rifampicin and adjusted doses of lopinavir/ritonavir tablets

rifampicin

lopinavir

ritonavir

tablets

adjusted doses

rifampicin

lopinavir

ritonavir


Input: We report here a case of TEN after administration of ciprofloxacin.

administration

a case

TEN

ciprofloxacin

ciprofloxacin


Input: Zidovudine induced pure red cell aplasia: a case report.

induced

a case

pure red cell aplasia

Zidovudine

Zidovudine


Input: A case of recall pneumonitis induced by gemcitabine is reported.

induced

A case

recall pneumonitis

gemcitabine

gemcitabine


Input: Albuterol-induced hypokalemia and its potential cardiac toxicity are discussed briefly.

induced

hypokalemia and its potential cardiac toxicity

Albuterol

Albuterol


Input: In the absence of an ideal dose-intense FU monotherapy regimen, monthly FU with low-dose LV provides a simple and economical means by which to achieve adequate FU efficacy in the treatment of advanced colorectal cancer.

treatment

monthly FU with low-dose LV

advanced colorectal cancer

monthly

FU

LV

low-dose

FU

LV


Input: OBJECTIVE: To report a patient developing fulminant liver failure while being treated with clarithromycin for pneumonia.

treated

a patient

fulminant liver failure

clarithromycin

clarithromycin

pneumonia


Input: The abnormal rhythm disappeared with the withdrawal of propranolol and when the drug was restarted a 2/1 S-A block was seen.

seen.

2/1 S-A block

propranolol

propranolol


Input: The Naranjo probability scale indicated a probable relationship between apnea and exposure to lamotrigine through breast-feeding in this infant.

a probable relationship

in this infant

infant

apnea

lamotrigine through breast-feeding

lamotrigine

breast-feeding


Input: Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.

after

Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma

temozolomide

temozolomide


Input: Since amiodarone was first marketed in 1992 in Japan, the incidence of amiodarone-induced thyrotoxicosis (AIT) has been increasing.

induced

thyrotoxicosis (AIT)

amiodarone

amiodarone

amiodarone


Input: The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease.

after

a man with no risk factors for coronary heart disease

man

myocardial infarction

chemotherapy containing etoposide

etoposide


Input: The use of beclomethasone diproprionate inhaler complicated by the development of an eosinophilic pneumonia reaction.

development

eosinophilic pneumonia reaction

beclomethasone diproprionate inhaler

inhaler

beclomethasone diproprionate


Input: Nephrotic syndrome related to systemic lupus erythematosus after griseofulvin therapy.

after

Nephrotic syndrome related to systemic lupus erythematosus

griseofulvin

griseofulvin


Input: Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.

mechanisms

poisoning

methanol

methanol


Input: We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.

induced

a case of

a 71-year-old man

for pericardial effusion

man

Kaposi's sarcoma (KS)

6 months with corticosteroid therapy (prednisolone 25 mg/day)

6 months

25 mg/day

prednisolone

pericardial effusion


Input: We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.

toxicity

a young boy with combined variable immunodeficiency syndrome

young

boy

acute myocardial ischemia

severe allergic reaction

acute epinephrine

intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously

epinephrine

immunoglobulin

combined variable immunodeficiency syndrome

intravenously

intravenous


Input: Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese.

associated

Hong Kong Chinese

Hong Kong Chinese

thyroid dysfunctions

lithium

lithium


Input: Metaxalone has only recently been associated with serotonin syndrome.

associated

serotonin syndrome

Metaxalone

Metaxalone


Input: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity.

related

18.6% of patients

osteonecrosis of the jaw (BRONJ)

intravenous bisphosphonates

Bisphosphonate

bisphosphonates

intravenous


Input: Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.

in

asthmatic children

children

Growth and adrenal suppression

high-dose fluticasone propionate

fluticasone propionate

high-dose

asthmatic


Input: A diagnosis of infliximab-induced lupus was made and the drug treatment was withdrawn.

induced

lupus

infliximab

infliximab


Input: AIMS: To identify the  human cytochrome P450 enzyme (s) involved in the in vitro metabolism of rosiglitazone, a potential oral antidiabetic agent for the treatment of type 2 diabetes-mellitus.

potential oral

rosiglitazone

rosiglitazone

type 2 diabetes-mellitus.

oral


Input: Neurotoxicity can occur at any time using high-dose cytosine therapy.

occur

Neurotoxicity

high-dose cytosine

high-dose

cytosine


Input: The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.

receiving

phenytoin hypersensitivity

fever, rash, and lymphadenopathy

phenytoin

phenytoin


Input: Magnesium tocolysis as the cause of urinary calculus during pregnancy.

cause

urinary calculus during pregnancy

Magnesium tocolysis

Magnesium


Input: Ocular ethambutol toxicity.

toxicity.

toxicity

Ocular ethambutol

Ocular

ethambutol


Input: Fatal intravascular autoimmune hemolytic anemia after fludarabine treatment for chronic lymphocytic leukemia.

after

Fatal intravascular autoimmune hemolytic anemia

fludarabine treatment

fludarabine

chronic lymphocytic leukemia


Input: A 74-year-old patient with idiopathic Parkinson's disease was evaluated for unintended sleep episodes that occurred after long-term treatment with 400 mg/day of L-dopa.

after

A 74-year-old patient with idiopathic Parkinson's disease

unintended sleep episodes

long-term treatment with 400 mg/day of L-dopa

idiopathic Parkinson's disease

400 mg/day

L-dopa

long-term treatment


Input: Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine.

developed

a patient with seropositive rheumatoid arthritis (RA)

Thrombotic thrombocytopenic purpura (TTP)

2 1/2 months of treatment with penicillamine

rheumatoid arthritis

penicillamine

2 1/2 months


Input: Phenolphthalein-induced toxic epidermal necrolysis.

induced

toxic epidermal necrolysis

Phenolphthalein

Phenolphthalein


Input: We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation.

induced

a 46-year-old woman

woman

delayed hypersensitivity reaction

ethylenediamine

ethylenediamine


Input: Physicians should be aware of the potentially lethal side effects of dapsone.

of

lethal side effects

dapsone

dapsone


Input: Acute myocardial necrosis during administration of amsacrine.

during

Acute myocardial necrosis

amsacrine

amsacrine


Input: Rapid identification of speech loss linked to FK506 may be important because reduction or cessation of the drug may be associated with reverse of speech loss.

linked

speech loss


Input: Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.

following

pulmonary fibrosis

1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy

1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)


Input: The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis.

related

associated ulcers

keratitis

methamphetamine abuse

methamphetamine

methamphetamine

methamphetamine


Input: MDS was diagnosed 8.4 months after beginning TMZ.

diagnosed

MDS

8.4 months after beginning TMZ

TMZ

8.4 months


Input: Uveitis associated with rifabutin therapy: a clinical alert.

associated

Uveitis

rifabutin therapy

rifabutin


Input: We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.

induced

a patient

SJS

acute onset of VBDS

ciprofloxacin

ciprofloxacin


Input: This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH.

trigger

MH

cresol

cresol


Input: Neonatal mydriasis: intravenous lidocaine adverse reaction.

adverse reaction.

Neonatal

Neonatal

Neonatal mydriasis

lidocaine

lidocaine


Input: Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation.

in

a patient

Acute renal failure

continuous povidone-iodine mediastinal irrigation

povidone

iodine

irrigation

povidone

iodine


Input: To our knowledge, this is the first case of griseofulvin-exacerbated lupus in which nephrotic syndrome has been observed.

exacerbated

the first case

lupus

nephrotic syndrome

griseofulvin

griseofulvin


Input: After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.

complication

CPM

lithium toxicity

blindness

lithium

lithium


Input: A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium.

reaction

A 71-year-old man

man

bullous

sulfonamide

sulfonamide

sulfacetamide sodium


Input: The authors report on two patients with corneal ulcers refractory to conventional treatment while the patients were undergoing oral colchicine therapy.

undergoing

two patients

two

corneal ulcers

oral colchicine therapy

colchicine

oral


Input: Vancomycin-induced vasculitis.

induced

vasculitis

Vancomycin

Vancomycin


Input: Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis.

cause

C. difficile colitis

cisplatin

cisplatin


Input: Nephrotic syndrome associated with lithium therapy.

associated

Nephrotic syndrome

lithium therapy

lithium


Input: We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B.

developed

2 patients

polyarteritis nodosa

vaccination against hepatitis B.

vaccination against hepatitis B.


Input: We recommend the cautious use of ketorolac in patients with underlying illnesses where NSAID-induced ototoxicity could result in adverse otologic consequences.

where

patients with underlying illnesses

underlying illnesses

NSAID-induced ototoxicity could result in adverse otologic consequences

ketorolac

ketorolac


Input: Colitis as a manifestation of infliximab-associated disseminated cryptococcosis.

associated

Colitis

infliximab

infliximab


Input: A 15-month-old girl with rhinopharyngitis was treated with a nasal solution containing the imidazoline derivative naphazoline.

treated

A 15-month-old girl with rhinopharyngitis

girl

a nasal solution containing the imidazoline derivative naphazoline

rhinopharyngitis

imidazoline derivative

naphazoline


Input: Three diabetic cases of acute dizziness due to initial administration of voglibose.

due

Three diabetic cases

Three

acute dizziness

initial administration of voglibose

voglibose

diabetic


Input: Fatal cold medication intoxication in an infant.

in

infant

infant

Fatal cold medication intoxication

cold medication

cold medication


Input: Case study: a modified topical treatment regimen for sodium warfarin-induced necrotizing fasciitis.

induced

necrotizing fasciitis

sodium warfarin

sodium warfarin


Input: Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.

taking

an elderly man

elderly

man

Marked QT prolongation and torsades de pointes secondary to acute ischemia

dofetilide

dofetilide

atrial fibrillation


Input: Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.

induced

peripheral vasculopathy

Methylphenidate and dextroamphetamine

dextroamphetamine

Methylphenidate


Input: The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.

cause

severe hemodynamic deterioration

systemic hypotension, pulmonary hypertension, and bronchoconstriction

The reversal of heparin by protamine

heparin

protamine

heparin

protamine


Input: OBJECTIVE: To report a case of severe apnea in an infant exposed to lamotrigine through breast-feeding.

in

an infant

infant

severe apnea

exposed to lamotrigine through breast-feeding

lamotrigine

breast-feeding


Input: Hemodynamic collapse following labetalol administration in preeclampsia.

following

Hemodynamic collapse

labetalol

labetalol

preeclampsia


Input: We report a case of a 35-year old female who developed new onset type II diabetes mellitus with hyperosmolar hyperglycaemic coma and acute renal failure following treatment with a SGA for a first manic episode.

developed

35-year old female

35-year old

female

type II diabetes mellitus with hyperosmolar hyperglycaemic coma and acute renal failure

treatment with a SGA

SGA


Input: We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).

occurrence

renal failure due to cholesterol crystal embolization

thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA)

intravenous

recombinant tissue-type plasminogen activator


Input: The asthma resolved within 24 hours following three albuterol inhalations.

resolved

three albuterol inhalations

asthma

three

albuterol

within 24 hours

inhalations


Input: Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication.

associated

two schizophrenic patients

two

schizophrenic

psychotic decompensations

concomitant neuroleptic medication

amantadine

amantadine

neuroleptic

neuroleptic

amantadine


Input: Clinicians should be aware of fasting hypoglycemia as an unusual but potentially serious complication of disopyramide therapy.

complication

fasting hypoglycemia

disopyramide

disopyramide