Input: Although they had complex medical problems, the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy.

related

seizures

ampicillin therapy

ampicillin


Input: Glaucoma secondary to epithelial downgrowth and 5-fluorouracil.

secondary

Glaucoma


Input: Of particular interest in this patient is the fluctuation of the QT interval at a stable dose of methadone, suggesting that a single normal electrocardiogram (ECG) does not guarantee that the patient is not at risk of ventricular arrhythmias.

at

this patient

fluctuation of the QT interval

a stable dose of methadone

methadone

a stable dose


Input: This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.

induced

acute kidney injury due to

DRESS/DIHS

zonisamide

zonisamide


Input: Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine.

considered

SLE

carbamazepine

carbamazepine


Input: BACKGROUND: Cyanamide, an aversive agent widely used in Japan, is known to induce various degrees of hepatic lesion with ground-glass inclusion bodies.

induce

various degrees of hepatic lesion with ground-glass inclusion bodies

Cyanamide

Cyanamide


Input: Oxcarbazepine-associated angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both) is a rare but potentially life-threatening reaction for which early recognition and management are vital.

associated

angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both)

Oxcarbazepine

Oxcarbazepine


Input: The combination therapy of interferon alpha and ribavirin was given to a 50-year-old female with CHC who had not responded to a previous treatment by interferon alpha.

given

a 50-year-old female with CHC who had not responded to a previous treatment by interferon alpha

female

combination therapy of interferon alpha and ribavirin

CHC

interferon alpha

ribavirin

interferon alpha

ribavirin


Input: Peripheral neuropathy associated with capecitabine.

associated

Peripheral neuropathy

capecitabine.

capecitabine


Input: DESIGN: We reviewed the medical records of four patients, who were seen by us between July 2000 and February 2004 for sudden onset of a central neurological syndrome within days of intrathecal MTX.

intrathecal

medical records of four patients

four

a central neurological syndrome

MTX

MTX

within days


Input: Prothipendylhydrochloride-induced priapism: case report.

induced

priapism

Prothipendylhydrochloride

Prothipendylhydrochloride


Input: Interstitial pneumonia probably associated with sorafenib treatment: An alert of an adverse event.

associated

Interstitial pneumonia

sorafenib treatment:

sorafenib


Input: He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy.

induced

hypokalemia (K 2.3 mmol/L)

licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy

licorice

disopyramide

bicalutamide

silodosin

prostate hypertrophy

prostate cancer

arrhythmia

disopyramide

bicalutamide

silodosin

licorice


Input: Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 5) between the patient's development of hepatotoxicity and the TMP-SMX therapy.

development

patient's

hepatotoxicity

TMP-SMX therapy

TMP-SMX


Input: Since its introduction in 2012, vismodegib has been implicated as a possible factor in seven reports of patient deaths.

implicated

seven reports of patient

seven

deaths

vismodegib

vismodegib


Input: Acceleration of ventricular response to atrial flutter after intravenous adenosine.

after

Acceleration of ventricular response

intravenous adenosine.

adenosine

intravenous

atrial flutter


Input: Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).

induction

diabetes

indapamide

hypertension

indapamide


Input: Physicians should be aware of the potential for the development of RS among children who are receiving long-term aspirin therapy for the treatment of systemic inflammatory illnesses.

development

children

children

RS

long-term aspirin therapy

systemic inflammatory illnesses

aspirin


Input: While a lower systemic steroid dosage may have been the provoking factor, we feel that an adverse reaction to oleic acid, a dispersing agent in the aerosol freon vehicle, is a strong possibility.

to

adverse reaction

oleic acid

oleic acid


Input: Baclofen withdrawal syndrome resulting from underdosing of oral baclofen should be considered as a potential source of prolonged fever in the intensive care unit.

resulting

Baclofen withdrawal syndrome

prolonged fever in the intensive care unit

underdosing of oral baclofen

oral

baclofen


Input: We present a case of sotalol-induced bradycardia reversed by glucagon.

induced

a case

bradycardia

sotalol

sotalol


Input: Hyperammonemia has been described as a complication of valproic acid therapy but may often be overlooked as a cause of lethargy in the postictal patient who presents to the emergency department.

complication

Hyperammonemia

valproic acid therapy

valproic acid


Input: Methylene blue has been found to be a potent inhibitor of monoamine oxidase (MAO), and several cases of serotonin toxicity have been reported recently following its administration.

following

several cases

serotonin toxicity

Methylene blue

Methylene blue


Input: She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough level 1 week before the onset of tetany.

had

elevated serum tobramycin trough level 1 week before the onset of tetany

a 3-week course of intravenous tobramycin

tobramycin

3-week course

intravenous

bronchiectasis


Input: In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.

after

blood pressure decreased

syncope

a sudden decrease in pulse rate

administration of isosorbide dinitrate (5 mg)

isosorbide dinitrate

5 mg


Input: The condition improved slowly after stopping medication and systemic steroids.

stopping

condition improved

steroids

steroids


Input: Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose.

cause

acute liver failure

Acetaminophen

Acetaminophen


Input: Patients treated with 5-ASA compounds who experience acute inflammatory symptoms or clinical deterioration not related to their gastrointestinal disease should be screened to rule out a lupus-like reaction.

experience

Patients

who experience acute inflammatory symptoms or clinical deterioration not related to their gastrointestinal disease

lupus-like reaction

5-ASA compounds

gastrointestinal disease


Input: Successful treatment with arsenic trioxide of a patient with ATRA-resistant relapse of acute promyelocytic leukemia.

treatment

a patient with ATRA-resistant relapse of acute promyelocytic leukemia

arsenic trioxide

arsenic trioxide

ATRA-resistant relapse of acute promyelocytic leukemia


Input: Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia.

after

Drug rash with eosinophilia and systemic symptoms

chlorambucil

chlorambucil

chronic lymphocytic leukaemia


Input: She manifested all the clinical symptoms and signs of caffeine toxicity.

manifested

She

She

all the clinical symptoms and signs of caffeine toxicity.

caffeine

caffeine


Input: Quinine-induced hearing loss.

induced

hearing loss

Quinine

Quinine


Input: Ezetimibe-induced acute pancreatitis.

induced

acute pancreatitis

Ezetimibe

Ezetimibe


Input: We report a case of drug-induced pemphigus caused by an angiotensin-converting enzyme inhibitor, captopril.

induced

a case

pemphigus

captopril

captopril


Input: We conclude that low-dose HU therapy in patients with thalassemia intermedia may increase total Hb levels sufficiently to eliminate the need for transfusions.

therapy

in patients with thalassemia intermedia

increase total Hb levels

low-dose HU therapy

thalassemia intermedia

HU

low-dose


Input: There is the risk of convulsions occurring in susceptible patients following the use of the new anaesthetic agents which are capable of inducing CNS excitability.

occurring

susceptible patients

convulsions

the use of the new anaesthetic agents which are capable of inducing CNS excitability

anaesthetic


Input: A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion.

developed

A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes

an abnormal response to the glucose tolerance test without other evidence of diabetes

postprandial hyperglycemia and glycosuria

a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion

psoriasis

halcinonide

cream


Input: Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations (N Engl J Med 321:1270, 1989), this is the first reported case of atheroembolic acute renal failure following t-PA therapy.

following

atheroembolic acute renal failure

t-PA therapy

t-PA


Input: A young woman developed galactorrhea during treatment with a new dibenzoxazepine antidepressant, amoxapine.

developed

A young woman

young

woman

galactorrhea

during treatment with a new dibenzoxazepine antidepressant, amoxapine

amoxapine


Input: After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.

linked to

the patient's

fluorosis

chronic use of niflumic acid

niflumic acid

chronic


Input: The hospital course of the acute renal failure is presented with a review of the literature on cases of acute renal failure after IVIG.

after

acute renal failure

IVIG

IVIG


Input: We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy.

after

3 cases of children with acute lymphoblastic leukemia

children

seizures and altered sensorium

L-asparaginase

acute lymphoblastic leukemia

L-asparaginase


Input: Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding.

induced

upper gastrointestinal bleeding

tolazoline

tolazoline


Input: Other thiazolidinediones currently in clinical trials may be able to provide the therapeutic benefits of troglitazone without significant hepatotoxicity.

provide

thiazolidinediones

thiazolidinediones


Input: OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.

associated

schizophrenic patient

a case of neuroleptic malignant syndrome (NMS)

fluphenazine

schizophrenic

fluphenazine


Input: CONCLUSIONS: Because of its structural similarity to the other vinca alkaloids, vinorelbine is believed to be responsible for SIADH in our patient.

responsible

SIADH

vinorelbine

vinorelbine


Input: Abnormal retinal function associated with isotretinoin therapy for acne.

associated

Abnormal retinal function

isotretinoin

acne

isotretinoin


Input: To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration.

due

first reported case

first

bromide intoxication

pyridostigmine bromide

pyridostigmine bromide


Input: In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma.

associated with

potentially life-threatening adverse events

including endometrial adenocarcinoma or uterine sarcoma

tamoxifen

tamoxifen

tamoxifen

tamoxifen


Input: We report the case of a patient with chronic lymphocytic leukemia (CLL) who developed fatal intravascular autoimmune hemolytic anemia (AIHA) after fludarabine treatment.

after

a patient with chronic lymphocytic leukemia (CLL)

fatal intravascular autoimmune hemolytic anemia (AIHA)

fludarabine treatment

fludarabine

chronic lymphocytic leukemia


Input: A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication.

developed

A 59-year-old woman with myasthenia gravis

woman

postoperative psychosis and was diagnosed as having bromide intoxication.

a large dose of pyridostigmine bromide

pyridostigmine bromide

myasthenia gravis

a large dose


Input: This is a report of a renal transplant patient with Pneumocystis pneumonia who developed chemical cellulitis and ulceration following the extravasation of intravenous pentamidine into the soft tissues of the left hand and forearm.

developed

a renal transplant patient with Pneumocystis pneumonia

renal transplant

chemical cellulitis and ulceration

intravenous pentamidine into the soft tissues of the left hand and forearm

Pneumocystis pneumonia

intravenous

pentamidine


Input: Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).

became

patient

reaction to the drug became more toxic

theophylline therapy

theophylline

99.9 and 149.9 micromol/L

18 and 27 microg/mL


Input: Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.

occurred

Dyspnea, hypoxemia, and pleuritic chest pain

rituximab administration

24 hours

rituximab


Input: Dermatitis to captopril.

to

captopril

captopril

Dermatitis


Input: Histological examination of the dacryolith suggested its derivation from breakdown products of adrenaline.

from

dacryolith

breakdown products of adrenaline

adrenaline


Input: Two patients developed diabetic coma when taking a combination of a thiazide diuretic and propranolol.

developed

Two patients

Two

diabetic coma

a combination of a thiazide diuretic and propranolol

thiazide

propranolol

thiazide

propranolol


Input: Platinum-resistant ovarian cancer (PROC) constitutes a therapeutic dilemma with limited efficacy from traditional cytotoxic agents.

from

limited efficacy

traditional cytotoxic agents

Platinum-resistant ovarian cancer (PROC)

traditional cytotoxic agents


Input: A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.

after

A patient

thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure

standard heparin

heparin


Input: Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.

associated

increased risk of lymphoproliferative

MG with MM

MG

MM


Input: We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide.

developed

a patient with multiple myeloma

acute life-threatening water intoxication

oral indomethacin and low dose intravenous cyclophosphamide

multiple myeloma

oral

intravenous

indomethacin

cyclophosphamide

low dose

indomethacin

cyclophosphamide


Input: Multifocal electroretinographic abnormalities in ethambutol-induced visual loss.

induced

visual loss

ethambutol

ethambutol


Input: She was on etanercept and methotrexate for rheumatoid arthritis.

for

She

She

etanercept and methotrexate

rheumatoid arthritis

etanercept

methotrexate

etanercept

methotrexate


Input: Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.

consist

minor dizziness or mild headache, although rare occurrences of seizures and hallucinations

secondary to ciprofloxacin treatment

ciprofloxacin


Input: We present a case of a 20-year-old woman who ingested 900 mg of glyburide causing refractory hypoglycemia resistant to treatment with intravenous dextrose, glucagon, and diazoxide.

ingested

a 20-year-old woman

woman

refractory hypoglycemia

900 mg of glyburide

900 mg

glyburide


Input: Etoposide-related myocardial infarction.

related

myocardial infarction

Etoposide

Etoposide


Input: Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.

toxicity

PPE

high-dose cytarabine

high-dose

cytarabine

haematologic malignancies


Input: She had been on Copaxone 20 mg/day treatment for 2 years when she first exhibited gastrointestinal symptoms.

exhibited

she

she

gastrointestinal symptoms

Copaxone 20 mg/day treatment for 2 years

Copaxone

20 mg/day

2 years


Input: The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.

developed

elderly patient with mixed dementia

elderly

TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia)

abrupt withdrawal of risperidone therapy

risperidone

mixed dementia


Input: Interferon-based treatments have the potential to decrease the burden of disease, but are complicated by side effects, including neuropsychiatric symptoms.

complicated

neuropsychiatric symptoms

Interferon

Interferon


Input: Long-term efficacy of adding fenofibric acid to moderate-dose statin therapy in patients with persistent elevated triglycerides.

efficacy

patients with persistent elevated triglycerides

adding fenofibric acid to moderate-dose statin therapy

persistent elevated triglycerides

fenofibric acid

statin

moderate-dose

fenofibric acid

statin


Input: Type 1 diabetes mellitus provoked by peginterferon alpha-2b plus ribavirin treatment for chronic hepatitis C.

provoked

Type 1 diabetes mellitus

peginterferon alpha-2b plus ribavirin treatment

peginterferon alpha-2b

ribavirin

chronic hepatitis C.

ribavirin

peginterferon alpha-2b


Input: A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia developed generalized erythema with high fever 3 weeks after taking sulfamethoxazole/trimethoprim.

taking

A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia

man

early diffuse cutaneous scleroderma with myositis

progressive interstitial pneumonia

generalized erythema with high fever

sulfamethoxazole/trimethoprim

sulfamethoxazole

trimethoprim

3 weeks after

trimethoprim

sulfamethoxazole


Input: Serotonin toxicity caused by an interaction between fentanyl and paroxetine.

caused

Serotonin toxicity

an interaction between fentanyl and paroxetine

fentanyl

paroxetine

fentanyl

paroxetine


Input: The sub-conjunctival haematoma in a patient receiving warfarin can pose a significant management challenge.

receiving

sub-conjunctival haematoma

warfarin

warfarin


Input: Toxic optic neuropathy associated with ethambutol: implications for current therapy.

associated

Toxic optic neuropathy

ethambutol

ethambutol


Input: The site of thrombosis and the chronological relationship with the IIR implicates a hypersensitivity to infliximab in the causation of the venous thrombosis in this case.

causation

venous thrombosis

infliximab

infliximab


Input: One week after the initial-dose of adalimumab (160 mg), which was initiated due to an acute exacerbation of Crohn's disease, the patient developed a fulminant cardiomyopathy.

developed

an acute exacerbation of Crohn's disease, the patient

fulminant cardiomyopathy

One week after the initial-dose of adalimumab (160 mg)

Crohn's disease

adalimumab

160 mg

One week


Input: RESULTS: Ethambutol, and to a lesser extent isoniazid, are both implicated in the development of visually related side effects.

development

visually related side effects

Ethambutol

isoniazid

isoniazid

Ethambutol

Ethambutol

isoniazid


Input: We report a case of an inadvertent increase in the international normalized ratio (INR) after the addition of bismuth subsalicylate for the treatment of diarrhea in an enterally fed patient receiving warfarin therapy.

after

an enterally fed patient

inadvertent increase in the international normalized ratio (INR)

addition of bismuth subsalicylate

warfarin therapy

diarrhea

bismuth subsalicylate

warfarin

bismuth subsalicylate

warfarin


Input: Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole.

to

patients

hazardous

triazolam

triazolam

ketoconazole

itraconazole

Oral


Input: LFT elevation is transient and the low risk of the SB-LOT therapy to increase LFT value can be limited when risk factors are considered.

the low risk

SB-LOT

increase LFT value

SB-LOT


Input: Nineteen cases of unusual enhanced vincristine neurotoxicity related to itraconazole have been reported in children.

related

Nineteen cases

children

Nineteen

children

unusual enhanced vincristine neurotoxicity

itraconazole

itraconazole


Input: Extended-release tolterodine 4 mg/day was then prescribed to manage overactive bladder.

prescribed

Extended-release tolterodine 4 mg/day

overactive bladder

Extended-release tolterodine

4 mg/day


Input: Although it is difficult to be certain of the direct link of amiodarone on the basis of a single case, it is reasonable to presume that this histopathology is associated with amiodarone-induced hypothyroidism and that involution changes represent the hypofunctional status of this drug-induced disorder.

induced

a single case

single

hypothyroidism

amiodarone

amiodarone

amiodarone


Input: The present report describes the first case of acute pancreatitis associated with danazol treatment of endometriosis.

associated

the first case

acute pancreatitis

danazol treatment of endometriosis

endometriosis

danazol


Input: Awareness of this route of intoxication might be important in patients in whom neurologic or psychiatric symptoms develop while large amounts of lidocaine cream are being used.

develop

neurologic or psychiatric symptoms

large amounts of lidocaine cream are being used

lidocaine

cream

large amounts


Input: Cephalosporin-induced leukopenia following rechallenge with cefoxitin.

induced

leukopenia

cefoxitin

Cephalosporin

Cephalosporin

cefoxitin


Input: Thrombotic thrombocytopenic purpura induced by trimethoprim-sulfamethoxazole in a Jehovah's Witness.

induced

a Jehovah's Witness

Thrombotic thrombocytopenic purpura

trimethoprim-sulfamethoxazole

trimethoprim-sulfamethoxazole


Input: This eruption appears to be a distinct cutaneous toxicity of PLD.

of

eruption

distinct cutaneous toxicity

PLD

PLD


Input: Granulocytopenia and agranulocytosis are considered among the most dangerous adverse effects of clozapine.

among

Granulocytopenia and agranulocytosis

clozapine

clozapine


Input: RESULTS: We recently experienced a case of fatal erlotinib-induced ILD, diagnosed based on clinical and radiologic findings, which occurred in a patient with radiation fibrosis.

induced

a patient with radiation fibrosis

radiation fibrosis

ILD

erlotinib

erlotinib


Input: Unusual hypersensitivity to warfarin in a critically ill patient.

to

a critically ill patient

critically ill

Unusual hypersensitivity

warfarin

warfarin


Input: Flumazenil reversal of benzodiazepine-induced sedation for a patient with severe pre-ECT anxiety.

induced

a patient with severe pre-ECT anxiety

severe pre-ECT anxiety

sedation

benzodiazepine

benzodiazepine


Input: We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.

associated

seizure

L-asparaginase therapy

L-asparaginase


Input: Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.

developed

a patient with Crohn's disease

severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral

infliximab infusion

infliximab

infusion

Crohn's disease


Input: She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.

despite

died within six weeks of developing congestive heart failure coupled with liver failure

regular use of desferrioxamine

desferrioxamine

haemosiderosis


Input: A 56-year-old Caucasian man who received concomitant chemotherapy and radiation for head and neck cancer developed fever concurrent with the administration of amifostine.

developed

A 56-year-old Caucasian man

Caucasian

man

fever

concomitant chemotherapy and radiation for head and neck cancer

concurrent with the administration of amifostine

head and neck cancer

amifostine

radiation

chemotherapy

amifostine

radiation

chemotherapy


Input: In this study, we report on three individual patients who received BTX-B and who subsequently developed parasympathetic dysfunction of the visual system after injections of BTX-B at remote sites.

developed

three individual patients

three

parasympathetic dysfunction of the visual system

BTX-B

BTX-B

BTX-B

BTX-B


Input: Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.

induced

autoimmune hepatitis

Minocycline

sporadic autoimmune hepatitis

Minocycline


Input: BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.

treated

women

women

Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism

sodium valproate for epilepsy

sodium valproate

epilepsy


Input: Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.

showed

Two cases of lepromatous leprosy with erythema nodosum leprosum

Two

discoloration of nail plate, subungual hyperkeratosis and onycholysis

high doses of clofazimine

lepromatous leprosy with erythema nodosum leprosum

clofazimine

high doses


Input: Doxycycline-induced photo-onycholysis.

induced

photo-onycholysis

Doxycycline

Doxycycline


Input: Case report: acute renal failure after administering intravenous immunoglobulin.

after

acute renal failure

administering intravenous immunoglobulin

immunoglobulin

intravenous


Input: Sweet's syndrome associated with sargramostim (granulocyte-macrophage colony stimulating factor) treatment.

associated

Sweet's syndrome

sargramostim (granulocyte-macrophage colony stimulating factor) treatment

sargramostim


Input: This is a rare case of ARDS associated with lithium intoxication.

associated

ARDS

lithium

lithium


Input: Intravenous haloperidol is generally well tolerated, but multiform ventricular tachycardia has been reported.

reported.

multiform ventricular tachycardia

Intravenous haloperidol


Input: To report a case of rhabdomyolysis and acute hepatitis associated with the coadministration of atorvastatin and diltiazem.

associated

rhabdomyolysis and acute hepatitis

coadministration of atorvastatin and diltiazem

atorvastatin

diltiazem

atorvastatin

diltiazem


Input: Ten hours after the second methotrexate injection, the patient experienced a diffuse pruritic papular eruption located mainly on the limbs.

experienced

the patient

diffuse pruritic papular eruption located mainly on the limbs

Ten hours after the second methotrexate injection

methotrexate

injection

Ten hours

second


Input: Flecainide and pharmacologically similar agents that interact with sodium channels may cause delirium in susceptible patients.

cause

susceptible patients

delirium

Flecainide and pharmacologically similar agents that interact with sodium channels

Flecainide


Input: An elderly man with procainamide hydrochloride-induced lupus syndrome had a circulating anticoagulant against factor XI and a biologic false-positive (BFP) test result for syphilis.

induced

An elderly man

elderly

man

lupus

procainamide hydrochloride

procainamide hydrochloride


Input: In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later.

associated

one patient

one

decrease in blood lactate levels

DCA

DCA

16 h later


Input: We report a case of noncardiogenic pulmonary edema developed after therapeutic trial of EO as sclerosing agent for esophageal varix.

developed

noncardiogenic pulmonary edema

EO

EO

esophageal varix


Input: That review suggested that patients receiving anti-D IGIV be monitored for those and other potential complications of hemoglobinemia, particularly disseminated intravascular coagulation (DIC).

complications

patients

hemoglobinemia, particularly disseminated intravascular coagulation (DIC)

receiving anti-D IGIV

anti-D IGIV


Input: Seizures associated with therapeutic doses of venlafaxine and trimipramine.

associated

Seizures

therapeutic doses of venlafaxine and trimipramine

venlafaxine

trimipramine

therapeutic doses

venlafaxine

trimipramine


Input: BACKGROUND: The risk/benefit ratio of warfarin therapy changes in the over 75s, when haemorrhagic side-effects become more common.

become

over 75s

over 75s

haemorrhagic side-effects

warfarin therapy

warfarin


Input: Norethisterone in these 69 pregnancies accounted for 33.3% (5 of 15) cases of clitoral hypertrophy diagnosed in 100,756 consecutive births.

accounted

69 pregnancies

clitoral hypertrophy

Norethisterone

Norethisterone


Input: Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.

complication

Interstitial fibrosis of the lung

methotrexate

methotrexate

psoriasis


Input: This is the first reported fatality due to this drug interaction and only the second case of serotonin syndrome reported with oxcarbazepine.

reported

serotonin syndrome

oxcarbazepine

oxcarbazepine


Input: Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.

complication

Purple glove syndrome

purple discoloration and swelling of the hands in the distribution of a glove

intravenous phenytoin administration through small dorsal veins of the hands

intravenous

phenytoin


Input: Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac.

linkage

an HIV-infected hemophiliac

intracranial bleeding

amprenavir

amprenavir

HIV


Input: Inadvertent subsequent rechallenge with celiprolol led to recurrence of the pneumonitis, 10 weeks after drug readministration.

led to

recurrence of the pneumonitis

Inadvertent subsequent rechallenge with celiprolol

10 weeks after drug readministration

celiprolol

10 weeks


Input: Flecainide had been started 2 weeks prior for atrial fibrillation.

for

Flecainide

atrial fibrillation

Flecainide


Input: In the absence of evidence of a potential role for concomitant medication i.e. hydroxychloroquine sulfate to play a role in the clinical, biochemical and morphological picture, an interaction between the herbal preparation and tibolone was suspected as the likely cause of liver damage.

suspected

liver damage

an interaction between the herbal preparation and tibolone

herbal preparation

tibolone

herbal preparation

tibolone


Input: Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as "retinoic acid syndrome." This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.

developed

a patient with APL

symptom complex referred to as "retinoic acid syndrome."

a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis

ATRA

a few weeks

APL


Input: During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes.

developed

a 50-year-old male with no history of heart disease

male

a newly prolonged QT interval and torsade de pointes

During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding

intravenous

terlipressin

recurrent gastrointestinal


Input: It is concluded that chloral hydrate and methaqualone may be administered safely without additional caution in prothrombin test monitoring during oral anticoagulant therapy.

caution

chloral hydrate and methaqualone

during oral anticoagulant therapy

chloral hydrate

methaqualone

anticoagulant

oral

chloral hydrate

methaqualone

anticoagulant


Input: Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.

associated

pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates

Amiodarone hydrochloride

Amiodarone hydrochloride


Input: Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.

major hazards

secondary hyperparathyroidism and vitamin D intoxication, potassium loss

hypophosphatemic osteomalacia with phosphate and calcitriol

phosphate

calcitriol

hypophosphatemic osteomalacia

phosphate

calcitriol


Input: He had priapism following the use of olanzapine.

following

priapism

olanzapine

olanzapine


Input: CONCLUSION: Our case shows a fatal side effect of erlotinib.

of

side effect

erlotinib

erlotinib


Input: Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients.

responsible

these patients

subsequent development of carcinoma of the corpus uteri

tamoxifen

tamoxifen


Input: Corticosteroids may be useful for therapy of some features of this syndrome, such as thrombocytopenia.

be useful

Corticosteroids

Corticosteroids

thrombocytopenia


Input: Eosinophilic cystitis after bladder instillation with dimethyl sulfoxide.

after

Eosinophilic cystitis

bladder instillation with dimethyl sulfoxide

dimethyl sulfoxide

bladder instillation


Input: Beginning ductopenia was present in two, suggesting that itraconazole might be responsible for the occurrence of prolonged drug-induced cholangiopathy.

responsible

two

ductopenia

itraconazole

prolonged drug-induced cholangiopathy

itraconazole


Input: A 15-kg weight gain developed in a patient during the third week of ibuprofen therapy.

developed

a patient

A 15-kg weight gain

ibuprofen

ibuprofen

the third week


Input: Cefoxitin-associated renal failure.

associated

renal failure

Cefoxitin

Cefoxitin


Input: The rash seen in this patient, who was treated with cephalexin, may be similar to the rash seen with ampicillin treatment of patients with infectious mononucleosis.

seen

patient

rash

cephalexin

cephalexin


Input: Two of our patients developed TD after 23 months and 34 months of ziprasidone monotherapy, respectively.

developed

Two of our patients

Two

TD

ziprasidone

ziprasidone

23 months

34 months


Input: We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.

during

two dark-skinned patients

two

dark-skinned

hyperpigmented skin and tongue lesions

combination therapy with IFN and ribavirin.

IFN

ribavirin

IFN

ribavirin


Input: Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.

after

Attenuation of asparaginase-induced hyperglycemia

substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation

Erwinia carotovora

Escherichia coli enzyme preparation


Input: It remains to be seen whether the hepatotoxicity associated with troglitazone is a drug-class effect or specific to troglitazone.

associated

hepatotoxicity

troglitazone

troglitazone


Input: Ampicillin-induced interstitial nephritis with generalised exfoliative dermatitis.

induced

interstitial nephritis with generalised exfoliative dermatitis

Ampicillin

Ampicillin


Input: High-dose intravenous mannitol infusion in various clinical settings may result in acute renal failure (ARF).

result

acute renal failure

High-dose intravenous mannitol infusion

mannitol

intravenous

infusion

High-dose


Input: A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.

therapy.

A 7-year-old boy developed a severe unilateral grand mal seizure

boy

a severe unilateral grand mal seizure

at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.

phenobarbitone

valproate

1.5 years later

valproate

phenobarbitone


Input: We report the first case of rhabdomyolysis related to the administration of clarithromycin without concurrent use of other medications.

related to

rhabdomyolysis

administration of clarithromycin without concurrent use of other medications

clarithromycin


Input: The authors report a further case of methimazole-associated liver damage and present a brief review of eleven previous cases found in the literature.

associated

a further case

eleven previous cases

eleven

liver damage

methimazole

methimazole


Input: A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy.

developed

A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease

cholestasis

3 months after initiation of azathioprine

azathioprine

3 months

primary polymyositis


Input: Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever.

following

a patient with typhoid fever

Hypersensitivity reaction

chloramphenicol

chloramphenicol

typhoid fever


Input: Allergic and irritant contact dermatitis to calcipotriol.

to

contact dermatitis

calcipotriol

calcipotriol


Input: A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen.

had

A 23-year-old woman with systemic lupus erythematosus

woman

hypersensitivity reaction

ibuprofen

systemic lupus erythematosus

ibuprofen


Input: We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.

case

an infant born to a mother

infant

WES

haloperidol

haloperidol


Input: Despite treatment with levofloxacin, acyclovir, and voriconazole, the patient developed high fevers.

developed

patient

high fevers

levofloxacin, acyclovir, and voriconazole

levofloxacin

acyclovir

voriconazole


Input: The 5 patients had severe renovascular disease which might thus represent a significant risk factor in the development of captopril-induced acute renal failure.

induced

The 5 patients had severe renovascular disease

renovascular disease

acute renal failure

captopril

captopril


Input: METHODS: Growth retardation was observed in six severely asthmatic children after introduction of high-dose fluticasone propionate treatment (dry powder).

after

six severely asthmatic children

six

children

Growth retardation

introduction of high-dose fluticasone propionate treatment (dry powder)

severely asthmatic

high-dose

fluticasone propionate

dry powder


Input: The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).

of

toxic effects

elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4)

methotrexate

methotrexate


Input: CONCLUSION: Zidovudine is well a known cause of anaemia and thus should be used with caution in the initiation of antiretroviral therapy.

cause

anaemia

Zidovudine

Zidovudine


Input: A 60-yr-old woman, established on paroxetine for depression, underwent excision of a chest wall myxofibrosarcoma and chest wall reconstruction.

established

A 60-yr-old woman

depression

woman

paroxetine

underwent excision of a chest wall myxofibrosarcoma and chest wall reconstruction

paroxetine

depression

myxofibrosarcoma


Input: Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).

induced

Papilloedema and hepatic dysfunction

perhexiline maleate (Pexid)

perhexiline maleate


Input: The volatile anesthetic halothane undergoes substantial biotransformation generating metabolites that mediate hepatotoxicity.

mediate

hepatotoxicity

volatile anesthetic halothane

halothane

volatile


Input: Case 4: A 61-year-old male alcoholic who remained completely abstinent while taking cyanamide for 3 years showed slight elevation of serum transaminases.

taking

61-year-old male alcoholic who remained completely abstinent

male

elevation of serum transaminases

cyanamide for 3 years

cyanamide

3 years

alcoholic


Input: These observations indicate that submassive hepatic necrosis may result from treatment with propylthiouracil and are consistent with the notion that sensitization mechanisms may be responsible for the hepatic injury induced by this drug.

result

submassive hepatic necrosis

propylthiouracil

propylthiouracil


Input: Two children with rheumatic fever developed anicteric hepatitis while on high-dose aspirin therapy.

developed

Two children with rheumatic fever

Two

children

anicteric hepatitis

high-dose aspirin

rheumatic fever

aspirin

high-dose


Input: The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.

induced

an 88-year-old man

man

hyperammonemia and mental status changes

valproate

valproate


Input: The mechanism of the decrease in plasma potassium induced by phosphate treatment was investigated in a 24-year-old hypertensive patient with hypophosphatemic osteomalacia, who was the youngest of four patients, belonging to a 23 number kindred of five generations.

induced

a 24-year-old hypertensive patient with hypophosphatemic osteomalacia, who was the youngest of four patients, belonging to a 23 number kindred of five generations

hypertensive

decrease in plasma potassium

phosphate treatment

phosphate

hypophosphatemic osteomalacia


Input: In the two cases, a combination of iloprost, a stable prostacyclin analogue (1 to 2 ng/kg/mn) with aspirin and dipyridamole was shown to inhibit ex vivo the heparin-induced platelet aggregation.

inhibit ex vivo

two cases

two

iloprost, a stable prostacyclin analogue (1 to 2 ng/kg/mn) with aspirin and dipyridamole

heparin-induced platelet aggregation

1 to 2 ng/kg/mn

iloprost

aspirin

dipyridamole

iloprost

aspirin

dipyridamole


Input: Adrenaline dacryolith: detection by ultrasound examination of the nasolacrimal duct.

Adrenaline dacryolith:

dacryolith

Adrenaline

Adrenaline

nasolacrimal duct


Input: Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.

developed

paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities

itraconazole

itraconazole


Input: OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.

during

a case

increased libido

fluvoxamine therapy.

fluvoxamine


Input: An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug.

exhibited

An 8-year-old child

child

colchicine intoxication

prophylactic doses of the drug

prophylactic doses

familial Mediterranean fever

colchicine


Input: Furthermore, the warfarin dose was again increased after discontinuation of ropinirole due to common gastrointestinal adverse effects.

due to

the warfarin dose was again increased after discontinuation of ropinirole

gastrointestinal adverse effects

warfarin


Input: Serotonin syndrome following metaxalone overdose and therapeutic use of a selective serotonin reuptake inhibitor.

following

Serotonin syndrome

metaxalone overdose

metaxalone

selective serotonin reuptake inhibitor

overdose

metaxalone

selective serotonin reuptake inhibitor


Input: The aim of this report is to describe the clinical and electroencephalographic findings seen in an elderly woman without previous history of seizures who developed a nonconvulsive generalized status epilepticus following acute withdrawal of lorazepam.

following

an elderly woman

elderly

woman

nonconvulsive generalized status epilepticus

acute withdrawal of lorazepam

lorazepam


Input: We describe a patient with androgen-independent prostate cancer in whom PSA continued to decrease for a period of 15 months after flutamide withdrawal.

after

a patient with androgen-independent prostate cancer

PSA continued to decrease for a period of 15 months

flutamide withdrawal

flutamide

androgen-independent prostate cancer


Input: Acute renal failure following intravenous immunoglobulin therapy in a HIV-infected patient.

following

a HIV-infected patient

HIV

Acute renal failure

intravenous immunoglobulin therapy

immunoglobulin

intravenous


Input: After a total of four doses of linezolid, the patient reported further discomfort.

reported

the patient

further discomfort

a total of four doses of linezolid

linezolid

four doses


Input: Although moderate myelosuppression is not uncommonly seen in patients treated with lenalidomide, aplastic anemia has not previously been reported to be associated with this agent.

associated

aplastic anemia

lenalidomide

lenalidomide


Input: This paper contributed to the identification of possible reactions in the oral cavity due to antiretroviral medication.

due

reactions in the oral cavity

antiretroviral medication

antiretroviral medication


Input: Persistent light reactivity from systemic quinine.

from

Persistent light reactivity

systemic quinine

quinine


Input: Based on the clinical status of the patient, it was suspected that several conditions contributed to the abnormal hypersensitivity to warfarin.

to

the patient

abnormal hypersensitivity

warfarin

warfarin


Input: Treatment of APL in pregnancy is controversial as the use of ATRA has been questioned due to the teratogenic effect of retinoids.

due

teratogenic effect

retinoids

retinoids


Input: Diazepam use by pregnant women can be associated with a later presentation of withdrawal symptoms in the neonate than that induced by the use of other drugs.

associated

neonate

neonate

later presentation of withdrawal symptoms in the neonate

Diazepam

Diazepam


Input: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.

developed

A 65-year-old patient

confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome

chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram

following initiation of fentanyl

citalopram

fentanyl

chronically

citalopram

fentanyl


Input: This case highlights rapid onset of adrenal insufficiency in a patient with CF-related liver disease treated briefly with a moderate CYP3A4 inhibitor.

onset

a patient with CF-related liver disease

rapid onset of adrenal insufficiency

briefly with a moderate CYP3A4 inhibitor

CYP3A4 inhibitor

CF-related liver disease


Input: The biochemistry of paracetamol hepatotoxicity is outlined and the increased susceptibility of alcoholic patients to the hepatotoxic effects of paracetamol is remarked upon.

remarked

alcoholic patients

hepatotoxic effects

paracetamol

paracetamol


Input: The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.

manifested

newborn

newborn

four day course of lethargy with unexplained high lithium levels

lithium

lithium


Input: The occurrence of severe AIHA in CLL patients treated with fludarabine has been reported by several authors.

treated

CLL patients

severe AIHA

fludarabine

CLL

fludarabine


Input: Corneal endothelial dysfunction associated with amantadine toxicity.

associated

Corneal endothelial dysfunction

amantadine

amantadine


Input: We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U.

development

3 patients

cutaneous scleroderma

the use of bleomycin in low cumulative doses of less than 100 U.

bleomycin

less than 100 U.


Input: This case suggests that sarcoidosis and pravastatin, two entities not frequently associated with myotonia, may interact in a synergistic manner to produce severe clinical myotonia in humans.

interact

humans.

severe clinical myotonia

pravastatin

pravastatin


Input: Disopyramide-induced heart block.

induced

heart block

Disopyramide

Disopyramide


Input: Telescoped digits of the hands and feet developed in a 69-year-old male with severe chronic tophaceous gout during allopurinol treatment.

developed

a 69-year-old male with severe chronic tophaceous gout

male

Telescoped digits of the hands and feet

allopurinol treatment

severe chronic tophaceous gout

allopurinol


Input: CONCLUSIONS: Jet-injection devices might constitute a helpful method to treat those patients affected by severe human insulin-induced lipoatrophy.

treat

patients

Jet-injection devices

insulin-induced lipoatrophy

Jet-injection


Input: We describe a relatively healthy, 9-year-old boy who developed a CA-MRSA skin and soft tissue infection and was treated with TMP-SMX.

treated

a relatively healthy, 9-year-old boy

boy

TMP-SMX

CA-MRSA skin and soft tissue infection

TMP-SMX


Input: Recurrent septicemia with lethal outcome during and after cyclosporine therapy in severe ulcerative colitis.

after

Recurrent septicemia with lethal outcome

cyclosporine

severe ulcerative colitis

cyclosporine


Input: Amifostine-induced fever: case report and review of the literature.

induced

fever

Amifostine

Amifostine


Input: We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache.

developed

a patient

spontaneous splenic infarction

sumatriptan

migraine headache

sumatriptan


Input: Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.

associated

Hepatotoxicity

Crohn's disease


Input: Neuropathy is a significant side effect of thalidomide therapy, which may limit its clinical use.

side effect

Neuropathy

thalidomide

thalidomide


Input: A possible mechanism for focal neurological deficit in brain-damaged patients on phenytoin therapy is discussed.

mechanism

brain-damaged patients

focal neurological deficit

phenytoin therapy

phenytoin

brain-damaged


Input: Pulmonary toxicity with mefloquine.

with

Pulmonary toxicity

mefloquine

mefloquine


Input: Ciprofloxacin is one drug that has been reported to cause interstitial nephritis.

cause

interstitial nephritis

Ciprofloxacin

Ciprofloxacin


Input: Acute renal failure during lisinopril and losartan therapy for proteinuria.

during

Acute renal failure

lisinopril and losartan

proteinuria

lisinopril

losartan

lisinopril

losartan


Input: We present the first case of a patient with priapism after oral intake of the phenothiazine prothipendylhydrochloride.

after

a patient

priapism

oral intake of the phenothiazine prothipendylhydrochloride

prothipendylhydrochloride

oral


Input: However, because diphenhydramine also exhibits type IA sodium channel blockade, cardiac toxicity is also possible.

because

also exhibits type IA sodium channel blockade, cardiac toxicity

diphenhydramine

diphenhydramine


Input: Ticlopidine-induced interstitial pulmonary disease: a case report.

induced

interstitial pulmonary disease

Ticlopidine

Ticlopidine


Input: Linezolid is a popular choice of antibiotic, especially for the treatment of orthopedic-related MRSA infections.

treatment

Linezolid

orthopedic-related MRSA infections

Linezolid


Input: We present a case of photo-onycholysis in a patient treated with doxycycline for acne vulgaris.

treated

a patient

photo-onycholysis

doxycycline

doxycycline

acne vulgaris


Input: Anticonvulsant hypersensitivity syndrome associated with Bellamine S, a therapy for menopausal symptoms.

associated

Anticonvulsant hypersensitivity syndrome

Bellamine S, a therapy for menopausal symptoms

menopausal symptoms.

Bellamine S


Input: CASE SUMMARY: A 66-year-old white woman with a 10-year history of hypertension and bronchial asthma was switched from immediate-release verapamil hydrocloride 40 mg tid to sustained-release verapamil 240 mg/d po for better hypertension control.

control.

A 66-year-old white woman with a 10-year history of hypertension and bronchial asthma

white

woman

bronchial asthma

switched from immediate-release verapamil hydrocloride 40 mg tid to sustained-release verapamil 240 mg/d po

hypertension

hypertension

immediate-release verapamil hydrocloride

sustained-release verapamil

240 mg/d

40 mg tid

po


Input: Due to the severity of the rash, temozolomide was permanently discontinued.

Due

rash

temozolomide

temozolomide


Input: Ovarian endometrioid carcinoma and endometriosis developing in a postmenopausal breast cancer patient during tamoxifen therapy: a case report and review of the literature.

during

a postmenopausal breast cancer patient

postmenopausal

Ovarian endometrioid carcinoma and endometriosis

tamoxifen therapy

tamoxifen

breast cancer


Input: CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.

cause

central nervous system-related adverse effects, including headache, dizziness and insomnia

The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors

levofloxacin

sparfloxacin

grepafloxacin

trovafloxacin

gatifloxacin

moxifloxacin


Input: Terlipressin-induced ventricular arrhythmia.

induced

ventricular arrhythmia

Terlipressin

Terlipressin


Input: CASE REPORT: We report a case of acute severe hepatitis resulting from erlotinib monotherapy in a patient with locally advanced pancreatic cancer.

resulting

a patient with locally advanced pancreatic cancer

acute severe hepatitis

erlotinib monotherapy

erlotinib

locally advanced pancreatic cancer


Input: We highlight two instances of systemic allergic reaction, and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use.

of

two instances

two

systemic allergic reaction

potential side effects

aprotinin

aprotinin

injections


Input: Acute pancreatitis associated with danazol treatment for endometriosis.

associated

Acute pancreatitis

danazol treatment

danazol

endometriosis


Input: CASE REPORT: We report the case of a 58 year old patient who, after 2 days of treatment with roxithromycin and betamethasone, manifested acute pancreatitis.

manifested

a 58 year old patient

58 year old

acute pancreatitis

after 2 days of treatment with roxithromycin

betamethasone

roxithromycin

betamethasone

2 days

roxithromycin

betamethasone


Input: It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.

associated

salt and water retention

ibuprofen

ibuprofen

phenylbutazone

indomethacin


Input: Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ were detected after treatment with tamoxifen for breast cancer.

detected

Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ

tamoxifen

breast cancer

tamoxifen


Input: This therapy was also complicated by Warfarin-induced skin necrosis.

induced

skin necrosis

Warfarin

Warfarin


Input: Immobilization, while Paget's bone disease was present, and perhaps enhanced activation of dihydrotachysterol by rifampicin, could have led to increased calcium-release into the circulation.

led

increased calcium-release

dihydrotachysterol

dihydrotachysterol


Input: Failure of plasmapheresis, corticosteroids and thionamides to ameliorate a case of protracted amiodarone-induced thyroiditis.

induced

thyroiditis

amiodarone

amiodarone


Input: Although neurotoxicity is a frequent complication of methotrexate therapy, fatal acute neurotoxicity is extremely uncommon, especially in adults.

complication

neurotoxicity

methotrexate therapy

methotrexate


Input: Intravenous sodium bicarbonate appears to be indicated prophylactically in combating the associated metabolic acidosis due to absorbed formic acid.

due

metabolic acidosis

absorbed formic acid

formic acid


Input: Allopurinol-associated hand and foot deformities in chronic tophaceous gout.

associated

hand and foot deformities

Allopurinol

Allopurinol

chronic tophaceous gout


Input: The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.

reaction.

anaphylactic reaction

25 UI of Miacalcic

immediate

Miacalcic

25 UI

immediate


Input: There are several documented case reports of serotonin toxicity when used with selective serotonin reuptake inhibitors.

reports

several documented case

several

serotonin toxicity

selective serotonin reuptake inhibitors

selective serotonin reuptake inhibitors

serotonin

selective serotonin reuptake inhibitors

serotonin


Input: A literature review revealed 83 other reported cases of rifampicin-induced renal insufficiency.

induced

83 other reported cases

renal insufficiency

rifampicin

rifampicin


Input: Complete regression of iatrogenic Kaposi's sarcoma due to corticosteroid treatment in a patient with tubercular pericarditis.

regression

a patient with tubercular pericarditis

tubercular pericarditis

corticosteroid

Kaposi's sarcoma

corticosteroid


Input: DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.

induced

immunosuppression

T-cell lymphocytopenia

Pneumocystis jiroveci pneumonia

brain abscess with Listeria monocytogenes

cutaneous Kaposi's sarcoma

temozolomide

exacerbated by corticosteroids

temozolomide

corticosteroids

corticosteroids

temozolomide


Input: The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients.

development

transplant recipients

transplant

cholelithiasis

cyclosporin

cyclosporin


Input: Rifampicin-induced adrenal insufficiency in the acquired immunodeficiency syndrome: difficulties in diagnosis and treatment.

induced

adrenal insufficiency

Rifampicin

Rifampicin


Input: Bisphosphonate-related osteonecrosis of the skull base.

related

osteonecrosis of the skull base

Bisphosphonate

Bisphosphonate


Input: Angioedema and dysphagia caused by contact allergy to inhaled budesonide.

inhaled

contact allergy

Angioedema and dysphagia

budesonide

budesonide


Input: Emergence of Philadelphia positive chronic myeloid leukaemia during treatment with hydroxyurea for Philadelphia negative essential thrombocythaemia.

treatment

Emergence of Philadelphia positive chronic myeloid leukaemia

hydroxyurea

hydroxyurea

Philadelphia negative essential thrombocythaemia


Input: Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism.

increases

concentrations and hypotensive effect of tizanidine

Ciprofloxacin

Ciprofloxacin

tizanidine


Input: 2-CdA induces lymphocytopenia, which may explain the improvement in this patient's psoriasis.

induces

patient's psoriasis

lymphocytopenia

psoriasis


Input: There is a dose-effect relationship between doxorubicin and the incidence of symptomatic cardiac failure.

relationship

symptomatic cardiac failure

doxorubicin

doxorubicin


Input: These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina.

evidence

damages the retina

ethambutol

ethambutol


Input: Two days after administration of Kalimate enema, he had profuse hematochezia, and a sigmoidoscopy showed diffuse colonic mucosal necrosis in the rectum and sigmoid colon.

after

he

he

profuse hematochezia

diffuse colonic mucosal necrosis in the rectum

Two days after administration of Kalimate enema

enema

Kalimate

Two days


Input: Conventional and diffusion-weighted MRI findings of methotrexate related sub-acute neurotoxicity.

related

sub-acute neurotoxicity

methotrexate

methotrexate


Input: Scleromyxedema in a patient with multiple sclerosis and monoclonal gammopathy on interferon beta-1a.

on

a patient with multiple sclerosis and monoclonal gammopathy

monoclonal gammopathy

Scleromyxedema

interferon beta-1a

interferon beta-1a

multiple sclerosis


Input: The literature search revealed 22 cases of hypersensitivity reaction to cyclosporine.

to

22 cases

hypersensitivity reaction

cyclosporine

cyclosporine


Input: The presence of a lymphocyte alveolitis with a predominance of CD4+ T cells in 3 RA patients and CD8+ T cells with a concomitant increase in neutrophils in another case suggests that immunologically mediated reactions may be one damage mechanism in MTX-induced pneumonitis.

induced

3 RA patients

a lymphocyte alveolitis with a predominance of CD4+ T cells

pneumonitis

CD8+ T cells with a concomitant increase in neutrophils

MTX

RA

MTX


Input: The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.

of

patients receiving ciprofloxacin

delayed elimination

methotrexate

methotrexate


Input: Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration.

following

Severe acute encephalopathy

intrathecal doxorubicin administration

intrathecal

doxorubicin


Input: Porcine factor VIII (pFVIII), which is used to control bleeding in patients with congenital or acquired haemophilia who have high-titre neutralizing antibodies to human FVIII, is not known to increase the risk of arterial or venous thrombosis.

increase

patients with congenital or acquired haemophilia who have high-titre neutralizing antibodies to human FVIII

risk of arterial or venous thrombosis.

Porcine factor VIII (pFVIII)

high-titre neutralizing antibodies to human FVIII

bleeding

congenital or acquired haemophilia

Porcine factor VIII


Input: In all the patients, pellagra symptoms appeared during isoniazid therapy.

appeared

all the patients

pellagra symptoms

isoniazid therapy

isoniazid


Input: Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma.

induced

pulmonary toxicity

gemcitabine

gemcitabine

metastatic gallbladder adenocarcinoma


Input: Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature.

induced

hyperglycaemic coma and neuroleptic malignant syndrome

Olanzapine

Olanzapine


Input: Neurologic symptoms resolved after stopping CAP for 4 weeks in Patient A, with no recurrence after reinitiating CAP alone at 2000 mg/m2.

after

Neurologic symptoms resolved

stopping CAP for 4 weeks

CAP

4 weeks


Input: OBJECTIVE: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.

interaction

a case

serotonin syndrome

fentanyl and citalopram

fentanyl

citalopram

fentanyl

citalopram


Input: We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.

emergence

a 12-year old white girl

heterozygous gene polymorphism of the CYP2B6-G516T.

12-year old

white

girl

psychosis

increased efavirenz concentration

efavirenz


Input: Severe erythroderma as a complication of continuous epoprostenol therapy.

complication

Severe erythroderma

continuous epoprostenol

epoprostenol

continuous


Input: FDE from cephalosporins has been rarely reported, and to the best of our knowledge there is no published report of ceftriaxone-induced FDE in the literature.

from

FDE

cephalosporins

cephalosporins


Input: CASE SUMMARY: A 58-year-old white woman developed fulminant liver failure while being treated with the macrolide antibiotic clarithromycin for pneumonia.

developed

A 58-year-old white woman

white

woman

fulminant liver failure

macrolide antibiotic clarithromycin for pneumonia

pneumonia

clarithromycin


Input: CONCLUSIONS: Marked elevation of serum CK may be a possible complication of olanzapine therapy.

complication

Marked elevation of serum CK

olanzapine therapy

olanzapine


Input: OBJECTIVE: To describe a case of severe skin necrosis resulting from peripheral intravenous administration of low-dose vasopressin in a patient with catecholamine-resistant septic shock.

resulting

a patient with catecholamine-resistant septic shock

skin necrosis

peripheral intravenous administration of low-dose vasopressin

peripheral intravenous administration

low-dose

vasopressin

catecholamine-resistant septic shock


Input: Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine.

associated

PV

penicillamine

penicillamine


Input: Recurrent hypotension immediately after seizures in nortriptyline overdose.

in

Recurrent hypotension immediately after seizures

nortriptyline overdose

nortriptyline

overdose


Input: We report a patient with recurrent, increasingly severe episodes of PPE, ultimately complicated by a severe bullous eruption, following successive cycles of high-dose cytarabine for the treatment of acute lymphoblastic leukaemia.

following

a patient

recurrent, increasingly severe episodes of PPE, ultimately complicated by a severe bullous eruption

cycles of high-dose cytarabine for the treatment of acute lymphoblastic leukaemia

acute lymphoblastic leukaemia

high-dose

cytarabine


Input: Intravenous diazepam exacerbated the seizures.

exacerbated

seizures

Intravenous diazepam

Intravenous

diazepam


Input: After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.

developed

she

she

severe anaphylaxis

cisplatin

cisplatin


Input: Cefuroxime-induced acute renal failure.

induced

acute renal failure

Cefuroxime

Cefuroxime


Input: We describe the clinical and liver biopsy morphologic features for 4 patients with minocycline-induced autoimmune hepatitis (group 1).

induced

4 patients

autoimmune hepatitis

minocycline

minocycline


Input: Intravitreal triamcinolone acetonide for persisting cystoid macular edema after penetrating keratoplasty.

for

Intravitreal triamcinolone acetonide

persisting cystoid macular edema

triamcinolone acetonide

Intravitreal


Input: We report a case of a 29-year-old liver transplant patient who suffered liver injury most likely induced by drug interaction between capecitabine and warfarin.

induced

a 29-year-old liver transplant patient

liver transplant

liver injury

drug interaction between capecitabine and warfarin

capecitabine

warfarin

capecitabine

warfarin


Input: DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.

induced

Patients with 5-FU-induced ectropion

ectropion

tender, red, scaled lids


Input: Restless legs syndrome may thus be an adverse effect of IFN alpha treatment.

adverse effect

Restless legs syndrome

IFN alpha treatment.

IFN alpha


Input: Treatment of chronic hepatitis C with interferon alpha (IFN-alpha) is relatively contraindicated in patients with psychiatric disorders because of possible severe psychiatric side effects.

contraindicated

patients with psychiatric disorders

psychiatric disorders

possible severe psychiatric side effects

interferon alpha (IFN-alpha)

chronic hepatitis C

interferon alpha


Input: METHODS: We report a patient who had an anaphylactic reaction during the intravenous infusion of cyclosporine.

during

a patient

anaphylactic reaction

intravenous infusion of cyclosporine

cyclosporine

intravenous infusion


Input: Gabapentin toxicity in renal failure: the importance of dose adjustment.

toxicity

renal failure

Gabapentin

Gabapentin


Input: We describe a case of a man treated with an EGFR-inhibitor (erlotinib) for a cell lung cancer who developed skin manifestations localized in an uncommon area and with an atypical evolution.

developed

a man

man

skin manifestations localized in an uncommon area and with an atypical evolution

EGFR-inhibitor (erlotinib)

cell lung cancer

EGFR-inhibitor


Input: We describe a case of clozapine-induced seizures in a patient with treatment-resistant schizophrenia.

induced

a patient with treatment-resistant schizophrenia

seizures

clozapine

clozapine

treatment-resistant schizophrenia


Input: Two fatal cases of poisoning by paracetamol are described.

by

Two fatal cases

Two

poisoning

paracetamol

paracetamol


Input: The neurotoxicity seen with HDARAC is dose-related and has occurred in up to 60 percent of treated patients.

related

60 percent of treated patients

60 percent

neurotoxicity

HDARAC

HDARAC


Input: The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis.

cause

nephrolithiasis and interstitial nephritis

HIV protease inhibitor indinavir

indinavir


Input: BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation.

adverse effect

wound healing

Colchicine

Colchicine


Input: Pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma.

complication

Pneumocystis carinii pneumonia

methotrexate

methotrexate

asthma


Input: 2-CdA typically causes a long-lasting state of immunodeficiency and the profound influence of this drug on the immune system has raised questions concerning the emergence of secondary neoplasms after its use.

causes

a long-lasting state of immunodeficiency

emergence of secondary neoplasms after its use


Input: CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.

resulting

acute myopia and angle-closure glaucoma

Topiramate

Topiramate


Input: Increased awareness is needed on the possible occurrence of LPD resembling gastric cancer in rheumatoid arthritis patients treated with MTX.

occurrence

rheumatoid arthritis patients

LPD

MTX

rheumatoid arthritis

MTX


Input: A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.

treated

patients

hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis

dapsone

dapsone

leprosy


Input: CONCLUSIONS: Intravitreal injection of triamcinolone acetonide may be an additional tool in the treatment of therapy-resistant cystoid macular edema after penetrating keratoplasty.

treatment

Intravitreal injection of triamcinolone acetonide

Intravitreal injection

triamcinolone acetonide

therapy-resistant cystoid macular edema


Input: Since its FDA approval in 2002, there are no known citations of ezetimibe-induced pancreatitis.

induced

pancreatitis

ezetimibe

ezetimibe


Input: Acute acoustic nerve palsy associated with vincristine therapy.

associated

Acute acoustic nerve palsy

vincristine therapy

vincristine


Input: Review of all reported cases of the use of ATRA in pregnancy revealed no serious adverse outcomes or congenital anomalies although only very few cases had exposure in the first trimester.

revealed

in pregnancy

pregnancy

adverse outcomes or congenital anomalies

ATRA

ATRA


Input: The first patient was a 57-year-old man with HIV and bipolar disease who developed rapid and severe weight gain when quetiapine was added to a stable atazanavir-ritonavir-based antiretroviral regimen.

developed

a 57-year-old man with HIV and bipolar disease

man

rapid and severe weight gain

quetiapine was added to a stable atazanavir-ritonavir-based antiretroviral regimen

HIV

bipolar disease

atazanavir

ritonavir

quetiapine

quetiapine

atazanavir

ritonavir


Input: A 43-year-old woman with multiple sclerosis (MS) had nephrotic syndrome 21 months after starting treatment with interferon (IFN)-beta-1b (subcutaneous administration).

had

A 43-year-old woman with multiple sclerosis (MS)

woman

nephrotic syndrome

21 months after starting treatment with interferon (IFN)-beta-1b (subcutaneous administration)

multiple sclerosis

interferon (IFN)-beta-1b

21 months


Input: RESULTS: An 81-year-old man with a history of neoplasies of the colon and prostate and anticoagulant treatment was referred for treatment of an ocular surface neoplasia on his left eye.

referred

An 81-year-old man with a history of neoplasies of the colon and prostate

man

an ocular surface neoplasia on his left eye

anticoagulant

anticoagulant

neoplasies of the colon and prostate


Input: CONCLUSION: The present findings suggest that: (i) amantadine probably exerts its anti-dyskinetic effect by acting on the "indirect" pathway; (ii) the pathophysiological mechanisms of subthalamotomy induced dyskinesias may differ from those involved in L-dopa induced dyskinesias; (iii) dyskinesias induced by STN surgery resolve spontaneously as compensatory mechanisms develop.

exerts

anti-dyskinetic effect

amantadine

amantadine


Input: We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.

developed

a previously healthy, postmenopausal woman

woman

anticonvulsant hypersensitivity syndrome

Bellamine S (belladonna alkaloids; ergotamine; phenobarbital)

hot flashes

Bellamine S

belladonna alkaloids

ergotamine

phenobarbital


Input: Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.

developed

Skin rash

hepatocellular failure

phenobarbital

3 weeks

2 weeks

phenobarbital


Input: Ceftriaxone was approved in 1997 for the treatment of otitis media despite previous studies that documented an association of ceftriaxone with elevated hepato-biliary enzymes and transient biliary stasis.

association of

elevated hepato-biliary enzymes and transient biliary stasis

ceftriaxone

otitis media

ceftriaxone


Input: A rare case of advanced ovarian carcinoma who developed difficulty walking 25 days after treatment with weekly paclitaxel.

developed

A rare case of advanced ovarian carcinoma

difficulty walking

25 days after treatment with weekly paclitaxel

advanced ovarian carcinoma

25 days

weekly

paclitaxel


Input: We report a case of cough following the administration of quinapril, with complete resolution after changing to the alternative ACE inhibitor fosinopril in a patient with essential hypertension.

following

patient with essential hypertension

cough

the administration of quinapril

quinapril

hypertension


Input: Liver disease induced by perhexiline maleate.

induced by

Liver disease

perhexiline maleate

perhexiline maleate


Input: OBJECTIVE: To report the occurrence of anaphylactoid reactions to intraperitoneal cisplatin in 3 patients.

to

3 patients.

anaphylactoid reactions

intraperitoneal cisplatin

cisplatin

intraperitoneal


Input: In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus.

caused

female with acute lymphoblastic leukemia

female

severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus

inadvertent doxorubicin administration intrathecally

doxorubicin

acute lymphoblastic leukemia

intrathecally


Input: These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN).

induced

skin lesions

antiviral therapy with interferon-alpha (IFN)

interferon-alpha (IFN).


Input: Clinicians should be aware of the proepileptogenic effect of venlafaxine and trimipramine at therapeutic doses and that this combination may eventually increase the risk of seizures.

eventually

increase the risk of seizures

venlafaxine and trimipramine at therapeutic doses

venlafaxine

trimipramine

therapeutic doses

venlafaxine

trimipramine


Input: We report the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin who developed acute respiratory distress syndrome (ARDS) after a single infusion of rituximab.

developed

the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin

man

refractory to steroids and intravenous immunoglobulin

acute respiratory distress syndrome (ARDS)

single infusion of rituximab

infusion

rituximab

ITP


Input: She had been prescribed two mood stabilizers and suffered from anticholinergic adverse effects and the movement disorder tardive dyskinesia (TD).

suffered from

anticholinergic adverse effects and the movement disorder tardive dyskinesia (TD)

prescribed two mood stabilizers

mood stabilizers


Input: CASE REPORT: We describe here a case of a 60 year old female that experienced a relapse of symptomatic hyperlactatemia after being switched from stavudine to zidovudine and how the case was managed at the Infectious Diseases Institute, Kampala, Uganda.

after

a case of a 60 year old female

60 year old

female

relapse of symptomatic hyperlactatemia

switched from stavudine to zidovudine

stavudine

zidovudine


Input: This report describes two patients who developed acute myelocytic leukemia only after exposure to cyclophosphamide, methotrexate, and 5-fluorouracil adjuvant therapy.

developed

two patients

two

acute myelocytic leukemia

exposure to cyclophosphamide, methotrexate, and 5-fluorouracil adjuvant therapy

cyclophosphamide

methotrexate

cyclophosphamide

methotrexate


Input: Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.

following

Reversible corneal keratinization


Input: CASE: We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM.

treated

woman

woman

severe human insulin-induced lipoatrophy

recombinant DNA human insulin

recombinant DNA human insulin


Input: METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.

presenting

mixed SS/NMS features

a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine)

venlafaxine

topiramate

divalproex sodium

risperidone

carbamazepine

overdose


Input: Hyperpigmentation is one of the cutaneous side effects of chemotherapautic agents, but it is usually accepted as a cosmetic problem.

of

Hyperpigmentation

chemotherapautic agents

chemotherapautic agents


Input: Pancreatitis is a very rare adverse effect associated with the use of amiodarone, and only four cases of amiodarone-induced pancreatitis have been reported in literature.

induced

four cases

four

pancreatitis

amiodarone

amiodarone


Input: The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.

adverse effects

one such case

one

less gastrointestinal intolerance

liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions

Macrodantin

Macrodantin


Input: CASE REPORT: A 29-year-old black man, HIV-infected since 1996, began highly active antiretroviral therapy (HAART) with zidovudine, lamivudine, and indinavir.

began

A 29-year-old black man, HIV-infected since 1996

black

man

highly active antiretroviral therapy (HAART) with zidovudine, lamivudine, and indinavir

zidovudine

lamivudine

indinavir

HIV

zidovudine

lamivudine

indinavir


Input: METHOD: The authors followed a patient with chronic HCV who received interferon and ribavirin and who developed hallucinations ultimately requiring psychiatric hospitalization.

developed

a patient with chronic HCV

hallucinations

interferon and ribavirin

interferon

ribavirin

chronic HCV

interferon

ribavirin


Input: This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.

associated

acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome

linezolid

linezolid


Input: Easily reversible hypoxemia and hypotension induced by nimodipine.

induced

hypoxemia and hypotension

nimodipine

nimodipine


Input: Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.

including

pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases

amiodarone

amiodarone


Input: Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients.

associated

four patients

four

Chronic photosensitivity

hydrochlorothiazide ingestion

hydrochlorothiazide

ingestion


Input: Chlorambucil central nervous toxicity: a significant side effect of chlorambucil therapy in childhood nephrotic syndrome.

side effect

central nervous toxicity

Chlorambucil

Chlorambucil

childhood nephrotic syndrome


Input: The mechanism of action of this centrally acting muscle relaxant is unknown; however, the observation of serotonin syndrome in patients with metaxalone overdose suggests a role in the serotonergic pathway.

in

patients

serotonin syndrome

centrally acting muscle relaxant

metaxalone overdose

centrally acting muscle relaxant

metaxalone

overdose


Input: In general, angiotensin converting enzyme (ACE) inhibitors should be discontinued in pregnancy, as they can induce an ACE fetopathy.

induce

pregnancy

pregnancy

ACE fetopathy

angiotensin converting enzyme (ACE) inhibitors

angiotensin converting enzyme (ACE) inhibitors


Input: Of 371 patients treated with 8MOP, three (0.8%) developed an acute dermatitis in the PUVA-treated areas.

developed

Of 371 patients

three (0.8%)

three (0.8%)

acute dermatitis

treated with 8MOP


Input: There is a putative role of liothyronine administration in precipitating or activating hyperthyroidism.

precipitating or activating

hyperthyroidism

liothyronine

liothyronine


Input: Neutropenic colitis during standard dose combination chemotherapy with nedaplatin and irinotecan for testicular cancer.

during

Neutropenic colitis

standard dose combination chemotherapy with nedaplatin and irinotecan for testicular cancer

testicular cancer

standard dose

nedaplatin

irinotecan

nedaplatin

irinotecan


Input: Brain metastases are a frequent finding in patients with advanced non-small cell lung cancer and concomitant administration of antiepileptic and chemotherapeutic drugs or epidermal growth factor receptor (EGFR) inhibitor is necessary in many cases.

necessary

patients with advanced non-small cell lung cancer

advanced non-small cell lung cancer

concomitant administration of antiepileptic and chemotherapeutic drugs or epidermal growth factor receptor (EGFR) inhibitor

antiepileptic

chemotherapeutic

epidermal growth factor receptor (EGFR) inhibitor

Brain metastases

antiepileptic

chemotherapeutic


Input: A female patient with HER2 positive, metastatic breast cancer presented with pulmonary infiltrates, and a plural effusion dyspnoea after several months of trastuzumab treatment.

presented

A female patient with HER2 positive, metastatic breast cancer

female

pulmonary infiltrates, and a plural effusion dyspnoea

trastuzumab

HER2 positive, metastatic breast cancer

trastuzumab

several months


Input: Thrombocytosis under ciprofloxacin and tazobactam/piperacillin.

under

Thrombocytosis

ciprofloxacin and tazobactam/piperacillin

ciprofloxacin

tazobactam

piperacillin

ciprofloxacin

tazobactam

piperacillin


Input: Quinine and its isomer quinidine are well-known causes of iatrogenic hypoglycaemia, due to excessive insulin secretion.

causes

iatrogenic hypoglycaemia, due to excessive insulin secretion

Quinine and its isomer quinidine

Quinine


Input: Therefore, it is reasonable to conclude that: 1) 2-CdA can induce durable complete remission in MCD patients but unfortunately it cannot cure the disease; 2) the possibility that 2-CdA may accelerate the transformation of MCD to NHL cannot be ruled out.

induce

durable complete remission

MCD


Input: Hyperammonemia secondary to valproic acid as a cause of lethargy in a postictal patient.

cause

a postictal patient

Hyperammonemia

valproic acid

valproic acid


Input: OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen.

receiving

patient

serotonin syndrome

clomipramine

clomipramine

clozapine

clomipramine

clozapine


Input: Fatal ventricular fibrillation after treatment with digoxin in a 27-year-old man with mitral leaflet prolapse syndrome.

after

a 27-year-old man with mitral leaflet prolapse syndrome

man

Fatal ventricular fibrillation

digoxin

digoxin

mitral leaflet prolapse syndrome


Input: Clostridium difficile colitis associated with cisplatin-based chemotherapy in ovarian cancer patients.

associated

ovarian cancer patients.

Clostridium difficile colitis

cisplatin-based chemotherapy

cisplatin

ovarian cancer

chemotherapy


Input: Lithium-induced Creutzfeldt-Jakob syndrome.

induced

Creutzfeldt-Jakob syndrome

Lithium

Lithium


Input: It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.

cause

marked thrombocytosis

simultaneous administration of ciprofloxacin and tazobactam/piperacillin

ciprofloxacin

tazobactam/piperacillin

ciprofloxacin

tazobactam/piperacillin


Input: Alone or in combination with corticosteroids, cyclosporine is an effective drug of choice for the resistant patients.

is

resistant patients

Alone or in combination with corticosteroids, cyclosporine

corticosteroids

cyclosporine

corticosteroids

cyclosporine


Input: Bull's-eye maculopathy associated with quinacrine therapy for malaria.

associated

Bull's-eye maculopathy

quinacrine

quinacrine

malaria


Input: Physicians should be aware that indinavir nephrolithiasis may cause papillary necrosis.

cause

papillary necrosis

indinavir nephrolithiasis

indinavir


Input: Following the institution of intravenous therapy with acyclovir, the patient developed fever, hemoptysis, and a pleural friction rub.

developed

the patient

fever, hemoptysis, and a pleural friction rub

acyclovir

acyclovir


Input: Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.

Due to

discomfort, diplopia and lagophthalmos, the haematoma

warfarin therapy and a surgical evacuation

warfarin


Input: Acute dystonia with thalamic and brainstem lesions after initial penicillamine treatment in Wilson's disease.

after

Acute dystonia with thalamic and brainstem lesions

penicillamine

penicillamine

Wilson's disease


Input: Fatal agranulocytosis in an Indian male receiving 100mg of dapsone daily, hospitalized for mid-borderline leprosy in type I reaction with triple nerve paralysis is reported.

receiving

mid-borderline leprosy in type I reaction with triple nerve paralysis

Indian

male

Fatal agranulocytosis

100mg of dapsone daily

dapsone

daily

mid-borderline leprosy in type I reaction with triple nerve paralysis


Input: The authors presented a case of pulmonary hypertension during lithium therapy, while she has been on lithium for 6 years.

during

she

she

pulmonary hypertension

lithium therapy

lithium

6 years


Input: BACKGROUND: Oxaliplatin is a platinum derivative, which is used in the treatment of colorectal cancer.

treatment

Oxaliplatin is a platinum derivative

Oxaliplatin

platinum derivative

colorectal cancer


Input: After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h.

developed

the patient

dry cough, subfebrile temperatures and dyspnea within 48 h.

received gemcitabine on day 1 of the second course

gemcitabine

within 48 h.


Input: As linezolid has been shown to have hematologic side effects, blood count monitoring is recommended in patients receiving this drug for long-term therapy.

have

hematologic side effects

linezolid

linezolid

long-term


Input: The role of Adriamycin in the production of cardiotoxicity is reviewed.

production

cardiotoxicity

Adriamycin

Adriamycin


Input: He began taking propafenone only 6 days prior to admission because of uncontrolled atrial fibrillation and symptoms of fatigue.

taking

propafenone

propafenone

atrial fibrillation

fatigue


Input: A 53-year-old man developed NMS without rigidity while taking olanzapine.

developed

A 53-year-old man

man

NMS without rigidity

olanzapine

olanzapine


Input: We report on a 14-year-old boy with severe haemophilia A who developed a portal vein thrombosis during continuous infusion of F VIII.

developed

a 14-year-old boy with severe haemophilia A

boy

a portal vein thrombosis

continuous infusion of F VIII

continuous

infusion

F VIII

haemophilia A


Input: Suxamethonium apnoea terminated with commercial serumcholinesterase.

terminated

Suxamethonium apnoea

commercial serumcholinesterase

commercial serumcholinesterase


Input: Fatal multiple drug intoxication following acute sertraline use.

following

multiple drug intoxication

acute sertraline use

sertraline


Input: OBSERVATIONS: We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll-like receptor (TLR) 7 agonist imiquimod.

observed

aggravation and spreading of a psoriatic plaque

the toll-like receptor (TLR) 7 agonist imiquimod

imiquimod

topically


Input: Hypercalcemia in an AIDS patient treated with growth hormone.

with

an AIDS patient

Hypercalcemia

growth hormone

AIDS

growth hormone


Input: Significant drug interaction: phenytoin toxicity due to erlotinib.

due

phenytoin toxicity

erlotinib

erlotinib


Input: A pharmacokinetic interaction between the selective serotonin reuptake inhibitor citalopram and a tricyclic antidepressant, clomipramine, was noted in a patient treated for major depression and obsessive-compulsive disorder.

interaction

a patient treated for major depression and obsessive-compulsive disorder

A pharmacokinetic interaction

the selective serotonin reuptake inhibitor citalopram and a tricyclic antidepressant, clomipramine

citalopram

clomipramine

depression

obsessive-compulsive disorder

citalopram

clomipramine


Input: They continued to rise for five more days before salicylate hepatotoxicity was suspected.

suspected.

hepatotoxicity

salicylate

salicylate


Input: The occurrence of neuromuscular blockade and the resulting potentiation of muscle relaxants during magnesium sulfate (MgSO4) administration is well known.

during

neuromuscular blockade

potentiation of muscle relaxants

magnesium sulfate

magnesium sulfate (MgSO4)


Input: Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride.

diagnosed

diabetes insipidus

lithium

lithium


Input: Gabapentin-induced mood changes with hypomanic features in adults.

induced

adults

adults

mood changes with hypomanic features

Gabapentin

Gabapentin


Input: Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma.

secondary to

Drug induced polymyositis

leuprolide acetate (Lupron) therapy

prostate carcinoma

leuprolide acetate (Lupron)


Input: Incomplete posterior hyaloid detachment after intravitreal pegaptanib injection in diabetic macular edema.

after

Incomplete posterior hyaloid detachment

intravitreal pegaptanib injection in diabetic macular edema

diabetic macular edema

pegaptanib

intravitreal

injection


Input: This paper reports a case of fatal perhexiline maleate liver injury.

a case of

liver injury

perhexiline maleate

perhexiline maleate


Input: During the second hospitalization it is possible that antipsychotic treatment combined with an antidepressant caused akathisia or there were symptoms of agitated depression and akathisia present at the same time, which is very difficult to determine in everyday clinical practice.

caused

akathisia

antipsychotic treatment combined with an antidepressant

antipsychotic

antidepressant

antidepressant

antipsychotic


Input: OBJECTIVES: To describe the presentation and treatment of acute isoniazid (INH) neurotoxicity appearing at an inner-city municipal hospital.

neurotoxicity

isoniazid (INH) neurotoxicity

isoniazid (INH)

isoniazid


Input: Clozapine, an atypical antipsychotic, can be toxic at doses 4 times a moderate dose.

be

toxic

doses 4 times a moderate dose

Clozapine

4 times a moderate dose

Clozapine


Input: This article presents a 3(1/2)-year-old child on valproic acid, lamotrigine, and phenytoin who developed simultaneous hepatotoxicity and bone marrow toxicity during a parainfluenza virus type 3 infection.

developed

a 3(1/2)-year-old child

child

simultaneous hepatotoxicity and bone marrow toxicity

valproic acid, lamotrigine, and phenytoin

valproic acid

lamotrigine

phenytoin

phenytoin

lamotrigine

valproic acid


Input: Reversible cholestasis with bile duct injury following azathioprine therapy.

following

Reversible cholestasis with bile duct injury

azathioprine

azathioprine


Input: The authors report five cases of tremor related to itraconazole therapy, which occurred within 1-12 months of initiating treatment and resolved gradually following itraconazole withdrawal.

related

tremor

itraconazole therapy,

itraconazole

within 1-12 months


Input: OBJECTIVE: To report a case of phenolphthalein-induced toxic epidermal necrolysis (TEN) in a patient maintained on several other medications more commonly known to be associated with TEN.

induced

a case of

a patient

toxic epidermal necrolysis (TEN)

phenolphthalein

maintained on several other medications more commonly known to be associated with TEN

phenolphthalein


Input: Clinical symptoms and leukopenia normalized after discontinuation of CBZ and administration of prednisolone at 40 mg.

normalized

Clinical symptoms and leukopenia normalized

discontinuation of CBZ and administration of prednisolone at 40 mg

CBZ

prednisolone

40 mg

CBZ

prednisolone


Input: A patient with alcoholic cerebellar degeneration had periodic alternating nystagmus during a period of phenytoin intoxication.

during

A patient with alcoholic cerebellar degeneration

alcoholic cerebellar degeneration

periodic alternating nystagmus

phenytoin

phenytoin