Input: Physicians should be aware that PLP can occur after initiation of paclitaxel.

occur

PLP

paclitaxel

paclitaxel


Input: Heparin-dependent antibodies and thrombosis without heparin-induced thrombocytopenia.

induced

thrombocytopenia

heparin

heparin


Input: Treatment of lithium tremor with metoprolol.

Treatment of

metoprolol

lithium tremor

lithium

metoprolol


Input: A 54-year-old man, treated with amiodarone, developed thyrotoxicosis.

developed

A 54-year-old man

man

thyrotoxicosis

amiodarone

amiodarone


Input: Gynaecomastia is a rarely reported adverse drug reaction due to isoniazid therapy.

adverse drug reaction

Gynaecomastia

isoniazid therapy

isoniazid


Input: The authors performed a literature search using PubMed and the search terms "gemcitabine" and "radiation recall" to find prior cases of radiation recall attributed to gemcitabine.

attributed

prior cases

radiation recall

gemcitabine

gemcitabine


Input: Carbamazepine-induced Diabetes mellitus.

induced

Diabetes mellitus

Carbamazepine

Carbamazepine


Input: She displayed symptoms of ST 8 days after the introduction of linezolid.

displayed

She

She

symptoms of ST

8 days after the introduction of linezolid

8 days

introduction

linezolid


Input: Naproxen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) whose side effects include tinnitus and transient hearing loss.

include

tinnitus and transient hearing loss

Naproxen

Naproxen


Input: The allopurinol hypersensitivity syndrome is a rare adverse drug reaction.

adverse

hypersensitivity syndrome

allopurinol

allopurinol


Input: The pulmonary toxicity is probably induced by piritrexim.

induced

pulmonary toxicity

piritrexim

piritrexim


Input: BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.

associated

retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus

Interferon (IFN)

Interferon


Input: We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.

complicated

a patient with a liver abscess due to Entamoeba histolytica

reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess

metronidazole therapy (total dose, 21 g over 14 days)

metronidazole

21 g

14 days

liver abscess

Entamoeba histolytica


Input: We present a Japanese male patient who underwent a living-donor kidney transplantation having received tacrolimus, mycophenolate mofetil, and prednisolone for immunosuppression.

received

a Japanese male patient who underwent a living-donor kidney transplantation

immunosuppression

Japanese

male

kidney transplantation

tacrolimus, mycophenolate mofetil, and prednisolone

immunosuppression

tacrolimus

mycophenolate mofetil

prednisolone

tacrolimus

mycophenolate mofetil

prednisolone


Input: Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.

due

Gold nephropathy

auranofin

Gold

auranofin

tolmetin


Input: We report three cases of amiodarone-induced torsades de pointe.

induced

three cases

three

torsades de pointe

amiodarone

amiodarone


Input: Torsades de pointes due to drug interaction between disopyramide and clarithromycin.

due to

Torsades de pointes

drug interaction between disopyramide and clarithromycin

disopyramide

clarithromycin

disopyramide

clarithromycin


Input: We describe a patient who developed HUS after treatment with mitomycin C (total dose 144 mg/m2) due to a carcinoma of the ascending colon.

developed

a patient

HUS

mitomycin C (total dose 144 mg/m2)

mitomycin C

144 mg/m2

carcinoma of the ascending colon


Input: In this case, 5-FU increased PHT, which in turn may have increased the PB concentration, suggesting that when fluoropyrimidine antitumor agents are administered to patients receiving PHT in combination with other drugs, some measures should be taken in consideration of secondary effects of antitumor agents on other drugs that may possibly interact with PHT, including frequent monitoring of blood drug concentration.

interact

patients

secondary effects of antitumor agents on other drugs

5-FU increased PHT, which in turn may have increased the PB concentration

PHT

PHT


Input: Severe loss of vision after removal of cataract caused by intravitreal triamcinolone in combination with photodynamic therapy for exudative age-related macular degeneration.

caused

Severe loss of vision

intravitreal triamcinolone

photodynamic

triamcinolone

photodynamic

exudative age-related macular degeneration

triamcinolone

photodynamic


Input: The CATAPULT I study shows that tirapazamine enhances the activity of cisplatin in patients with advanced NSCLC and confirms that hypoxia is an exploitable therapeutic target in human malignancies.

enhances

patients with advanced NSCLC

enhances the activity of cisplatin

tirapazamine

tirapazamine

advanced NSCLC


Input: Cardiac arrest associated with sulprostone use during caesarean section.

associated

Cardiac arrest

sulprostone

sulprostone


Input: Linear IgA bullous dermatosis occurring after carbamazepine.

occurring

Linear IgA bullous dermatosis

carbamazepine

carbamazepine


Input: Erythropoietin is beneficial in mitomycin-induced hemolytic-uremic syndrome.

beneficial

Erythropoietin

mitomycin-induced hemolytic-uremic syndrome

Erythropoietin


Input: Hypothyroidism, occurring in up to 11 percent of patients treated with amiodarone, can also alter drug metabolism and sensitize the central nervous system, thus increasing the potential for toxicity.

occurring

11 percent of patients

11 percent

Hypothyroidism

amiodarone

amiodarone


Input: We report the first case of herpes esophagitis in a renal transplant patient treated with Cyclosporine A while on chronic steroid therapy.

in

a renal transplant patient

herpes esophagitis

Cyclosporine A while on chronic steroid therapy

Cyclosporine A

chronic steroid

renal transplant

Cyclosporine A

chronic steroid


Input: Severe hepatocellular dysfunction following cyproterone acetate therapy.

following

Severe hepatocellular dysfunction

cyproterone acetate

cyproterone acetate


Input: It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.

immunoallergic reaction

3-week sulphasalazine syndrome

sulphasalazine

sulphasalazine


Input: Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy.

experienced

Two patients with bipolar affective disorder and a history of bronchospastic phenomena

Two

a history of bronchospastic phenomena

tremor

lithium carbonate therapy

lithium carbonate

bipolar affective disorder


Input: Acute renal failure most likely was secondary to the nephrotoxic effect of captopril on chronically hypoperfused kidneys.

nephrotoxic effect

chronically hypoperfused kidneys

chronically hypoperfused kidneys

Acute renal failure

captopril

captopril


Input: We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer.

toxicity

a patient with metastatic breast cancer

skin toxicity

radiotherapy-enhanced aminoglutethimide

metastatic breast cancer

aminoglutethimide


Input: Clinicians should also be aware of the possibility of serotonin syndrome when encountering a patient taking serotonergic drugs who presents with characteristic symptoms of serotonin syndrome.

taking

a patient

serotonin syndrome

serotonergic drugs

serotonergic drugs


Input: Such a rapid and relentless progression of methyldopa-induced liver injury is undoubtedly rare, but it may be prevented by careful supervision of patients who exhibit liver function abnormalities early in the course of therapy.

induced

liver injury

methyldopa

methyldopa


Input: In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.

observed

eight patients

eight

mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L

a single 200 mg intravenous dose of lorcainide

a single 200 mg

intravenous

lorcainide


Input: Nitrendipine-induced gingival hyperplasia.

induced

gingival hyperplasia

Nitrendipine

Nitrendipine


Input: Extensive immunological investigations were performed in a patient with definite seronegative rheumatoid arthritis who developed hypogammaglobulinemia in the course of gold therapy.

developed

a patient with definite seronegative rheumatoid arthritis

hypogammaglobulinemia

gold therapy

rheumatoid arthritis

gold


Input: When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.

developed

he

weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.

SASP was changed to 5-aminosalicylic acid (5-ASA)

SASP

5-aminosalicylic acid


Input: One case of tacrolimus-induced hepatic VOD developing after lung transplantation (LT) has been recently reported.

induced

hepatic VOD

tacrolimus

after lung transplantation (LT)

tacrolimus


Input: We describe a case of an NHL patient who received rituximab and developed symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP).

developed

an NHL patient

symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP)

rituximab

NHL

rituximab


Input: We describe a case of TdP caused by a drug interaction in a 76-year-old woman taking long-term disopyramide after she was given clarithromycin concomitantly for chronic bronchitis.

taking

76-year-old woman

woman

TdP

long-term disopyramide

clarithromycin

chronic bronchitis

long-term disopyramide

clarithromycin

long-term disopyramide

clarithromycin


Input: Thus, clinical recognition of sleep disordered breathing should be taken into account when rheumatoid arthritis patients are to be treated with infliximab.

with

rheumatoid arthritis patients

sleep disordered breathing

infliximab

infliximab

rheumatoid arthritis


Input: We present a case of a sustained monomorphic ventricular tachycardia following adenosine infusion.

following

sustained monomorphic ventricular tachycardia

adenosine infusion

adenosine

infusion


Input: Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.

Provocation

three adolescent patients

three

adolescent

non-convulsive status epilepticus

tiagabine

tiagabine


Input: We recommend that a TMA in association with quinine be consistently referred to as quinine-associated thrombotic microangiopathy (quinine-TMA) to better distinguish this entity from idiopathic TTP.

associated

quinine-associated thrombotic microangiopathy (quinine-TMA)

quinine

quinine


Input: The authors describe a case of oral-facial dyskinesia that occurred after discontinuation of amoxapine, and antidepressant which may also have neuroleptic effects.

occurred

oral-facial dyskinesia

discontinuation of amoxapine, and antidepressant which may also have neuroleptic effects

antidepressant

amoxapine


Input: A 34-year-old HIV-infected man who had recently initiated efavirenz-based antiretroviral therapy was diagnosed with disseminated Histoplasma capsulatum infection.

initiated

A 34-year-old HIV-infected man

disseminated Histoplasma capsulatum infection

man

initiated efavirenz-based antiretroviral therapy

HIV

efavirenz

antiretroviral

efavirenz

antiretroviral


Input: Aminoglutethimide was discontinued until completion of radiotherapy, and the rash resolved.

and

the rash resolved

Aminoglutethimide was discontinued until completion of radiotherapy

Aminoglutethimide


Input: We explored ophthalmic and neurologic findings in two children who have been exposed prenatally to VGB.

explored

two children

two

children

ophthalmic and neurologic findings

exposed prenatally to VGB

VGB


Input: Two cases are described of chronic schizophrenic patients maintained on depot neuroleptics, who developed severe extrapyramidal symptoms following a period of heavy betel nut consumption.

developed

Two cases

Two

severe extrapyramidal symptoms

heavy betel nut consumption

depot neuroleptics

chronic schizophrenic

depot neuroleptics

betel nut


Input: Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature.

after

younger individuals

younger

acute amnestic episode

intake of clioquinol

clioquinol

intake


Input: In a patient with severe renovascular hypertension, nonoliguric acute renal failure developed after she received captopril treatment.

after

a patient with severe renovascular hypertension

she

nonoliguric acute renal failure

captopril

renovascular hypertension

captopril


Input: A 30-year-old pharmacist suffered from acute allergic contact dermatitis due to 4-chloro-7-nitrobenzofurazan (NBD-Cl).

suffered

A 30-year-old pharmacist

acute allergic contact dermatitis

4-chloro-7-nitrobenzofurazan (NBD-Cl)


Input: CONCLUSION: This rare case of PTU-induced ANCA-associated vasculitis manifested with ototoxicity in combination with systemic involvement.

induced

ANCA-associated vasculitis manifested with ototoxicity in combination with systemic involvement

PTU

PTU


Input: A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.

induced

unilateral gingival hyperplasia

phenytoin

phenytoin


Input: We describe two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis in whom accelerated nodulosis developed during methotrexate therapy.

developed

two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis

two

accelerated nodulosis

methotrexate therapy

methotrexate

rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis


Input: The clinical data suggest that anterior lumbosacral radiculopathy is also a type of neurologic complication associated with intrathecal methotrexate treatment.

associated

anterior lumbosacral radiculopathy

intrathecal methotrexate

intrathecal

methotrexate


Input: At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected.

due

toxicity

simvastatin and all antiviral drugs

simvastatin


Input: A major limitation in the use of amphotericin B is its potential to cause nephrotoxicity.

cause

nephrotoxicity

amphotericin B

amphotericin B


Input: We report a case of hyperpigmentation due to bleomycin treatment in a patient with acquired immune deficiency syndrome (AIDS).

due

a patient with acquired immune deficiency syndrome (AIDS)

hyperpigmentation

bleomycin

bleomycin

acquired immune deficiency syndrome


Input: Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.

induced

a patient with autoimmune hepatitis

myelosuppression

Azathioprine

thiopurine methyltransferase deficiency

autoimmune hepatitis

Azathioprine


Input: Captopril-associated "pseudocholangitis'.

associated

pseudocholangitis

Captopril

Captopril


Input: A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman.

caused

psoriasis

a 47-year-old woman

woman

toxic hepatitis

combination therapy with methotrexate and etretinate

etretinate

methotrexate

severe psoriasis

methotrexate

etretinate


Input: Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.

stopping

highly effective

Thrombin

intractable arterial hemorrhage

Thrombin


Input: Carboplatin hypersensitivity presenting as coronary vasospasm - a case report.

presenting

coronary vasospasm

Carboplatin

Carboplatin


Input: Severe hypoglycemia from Helicobacter pylori triple-drug therapy and insulin detemir drug interaction.

from

Severe hypoglycemia

Helicobacter pylori triple-drug therapy and insulin detemir drug interaction

Helicobacter pylori triple-drug

insulin detemir drug

insulin detemir drug

Helicobacter pylori triple-drug


Input: The aim of this study was to describe the occurrence of acute coronary syndromes in 3 cases of rituximab infusions.

occurrence

acute coronary syndromes

rituximab infusions

rituximab

infusions


Input: Acute pharmacokinetic and pharmacodynamic interactions between phenytoin and isradipine were probably responsible for the lethargy, dysarthria, ataxia, and weakness our patient developed.

responsible

the lethargy, dysarthria, ataxia, and weakness

Acute pharmacokinetic and pharmacodynamic interactions between phenytoin and isradipine

phenytoin

isradipine

phenytoin

isradipine


Input: A patient suffering from a rare enzyme deficiency developed a malignant neuroleptic syndrome after having been treated with one single dose of haloperidol.

treated

A patient suffering from a rare enzyme deficiency

malignant neuroleptic syndrome

one single dose of haloperidol

haloperidol

one single dose

enzyme deficiency


Input: Captopril is known to be associated with dermatologic, hematologic, and pulmonary adverse effects.

associated

dermatologic, hematologic, and pulmonary adverse effects

Captopril

Captopril


Input: Here, we present a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient that resolved completely with withdrawal of the drug and treatment with corticosteroids.

resolved

a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient

withdrawal of the drug and treatment with corticosteroids

corticosteroids


Input: Other upper tract neoplasms after cyclophosphamide are reviewed.

after

upper tract neoplasms

cyclophosphamide

cyclophosphamide


Input: Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes.

receiving

Four patients

Four

retinal changes

high-dose tamoxifen for greater than 1 year

1 year

high-dose

tamoxifen


Input: Retinal dysfunction and anterior segment deposits in a patient treated with rifabutin.

treated

patient

Retinal dysfunction and anterior segment deposits

rifabutin

rifabutin


Input: Carbamazepine induced right bundle branch block in a Greenlandic patient.

induced

Greenlandic patient

Greenlandic

right bundle branch block

Carbamazepine

Carbamazepine


Input: RESULTS: Both cases presented here describe corneal ulcers that persisted and showed signs of worsening during weeks of frequent topical dosing with moxifloxacin.

worsening

Both cases

corneal ulcers that persisted

weeks of frequent topical dosing with moxifloxacin

topical

moxifloxacin

frequent


Input: We describe a case of poisoning with 3,4-methylenedioxymet-amphetamine Ecstasy that presented with all the features suggestive of a fatal outcome, including a creatinine phosphokinase level markedly higher than any previously reported.

presented

a case

poisoning

creatinine phosphokinase level markedly higher

3,4-methylenedioxymet-amphetamine Ecstasy


Input: Ramipril-induced cutaneous vasculitis is particularly rare and our case was atypical because the patient had tolerated lisinopril before.

induced

the patient had tolerated lisinopril before

tolerated lisinopril

cutaneous vasculitis

Ramipril

Ramipril


Input: To date, this is the first reported case of what appears to be isolated thrombocytopenia associated with lansoprazole.

associated

isolated thrombocytopenia

lansoprazole

lansoprazole


Input: A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.

developed

A 7-year-old girl

girl

diabetes mellitus and exocrine pancreatic insufficiency

3.5 years of almost continuous treatment with azathioprine and/or prednisone

azathioprine

prednisone

azathioprine

prednisone

idiopathic auto-immune haemolytic anaemia

3.5 years

azathioprine

prednisone


Input: The human immunodeficiency virus protease inhibitor ritonavir is a potent inhibitor of the cytochrome P450 3A4 enzyme, and ritonavir's concomitant administration with the substrates of this enzyme may lead to dangerous drug interactions.

lead

drug interactions

ritonavir's concomitant administration with the substrates of this enzyme

ritonavir

substrates of this enzyme

substrates of this enzyme

ritonavir


Input: There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.

induced

children

children

thrombocytopenia

heparin

heparin


Input: Unintended exposure to acyclovir early in pregnancy, which is not uncommon, may cause excessive maternal and physician anxiety.

cause

excessive maternal and physician anxiety

Unintended exposure to acyclovir

acyclovir


Input: The ACE inhibitors can cause various skin side effects; however, it rarely causes cutaneous vasculitis.

cause

skin side effects

ACE inhibitors

ACE inhibitors


Input: Salicylate intoxication was excluded, and theophylline was finally incriminated.

incriminated.

theophylline

theophylline


Input: We present a case of stroke after PPA ingestion that occurred 4 months after the recall in an 8-year-old boy on chronic peritoneal dialysis.

after

an 8-year-old boy on chronic peritoneal dialysis

boy

stroke

PPA

PPA

4 months


Input: Cerebral infarcts in a pediatric patient secondary to phenylpropanolamine, a recalled medication.

secondary

pediatric patient

pediatric

Cerebral infarcts

phenylpropanolamine

phenylpropanolamine


Input: To our knowledge, our report is one of the first on shock and angio-oedema from irbesartan.

from

shock and angio-oedema

irbesartan

irbesartan


Input: Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography.

associated

two cases

two

macular edema

retinopathy

interferon

interferon


Input: This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy.

after

a 13-year-old female with a right frontal high-grade glioma and complex partial seizures

female

right frontal high-grade glioma

localized purpura

23 months of lamotrigine monotherapy

lamotrigine

23 months

complex partial seizures


Input: Patient 1 presented bilateral ballism 1 week after intravenous heroin injection.

presented

Patient 1

bilateral ballism

intravenous heroin injection

intravenous

injection

heroin


Input: He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal.

following

He

He

hyperkalemic

timolol

timolol


Input: Ischaemic colitis in a patient taking meloxicam.

taking

a patient

Ischaemic colitis

meloxicam

meloxicam


Input: Leflunomide-associated infections in rheumatoid arthritis.

associated

infections

Leflunomide

Leflunomide

rheumatoid arthritis


Input: Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases.

during

two cases

two

Cutaneous sarcoidosis

interferon alfa and ribavirin treatment of hepatitis C virus infection

alfa

ribavirin

hepatitis C virus infection

alfa

ribavirin


Input: Acute renal failure in a child associated with acyclovir.

associated

a child

child

Acute renal failure

acyclovir

acyclovir


Input: Bevacizumab is a recently developed monoclonal antibody against vascular endothelial growth factor receptor used to inhibit angiogenesis.

inhibit

Bevacizumab is a recently developed monoclonal antibody

angiogenesis

Bevacizumab


Input: Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine.

developed

Two patients with rheumatoid arthritis

Two

hepatotoxicity

D-penicillamine

D-penicillamine

rheumatoid arthritis


Input: Fatal venous thrombembolism complicating imatinib therapy in a patient with metastatic gastrointestinal stromal tumor.

complicating

a patient with metastatic gastrointestinal stromal tumor

Fatal venous thrombembolism

imatinib

imatinib

metastatic gastrointestinal stromal tumor


Input: However, acute cardiomyopathy and pericarditis secondary to methylphenidate use has been rarely reported.

use

acute cardiomyopathy and pericarditis

methylphenidate

methylphenidate


Input: Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.

induced

wide QRS complex dysrhythmia

Propoxyphene

Propoxyphene


Input: Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood.

induced

Simvastatin plasma concentration increased 30 times in this patient

Simvastatin plasma concentration increased 30 times

muscle toxicity

statin

statin


Input: Poorly controlled hypertension in a painter with chronic lead toxicity.

with

a painter

Poorly controlled hypertension

lead

lead


Input: It was concluded that ANCA is closely related to the pathogenesis of crescentic glomerulonephritis and that treatment with PTU appeared to induce ANCA.

induce

ANCA

PTU

PTU


Input: Gelatinous transformation of bone marrow following chemotherapy for myeloma.

following

Gelatinous transformation of bone marrow

chemotherapy

chemotherapy

myeloma


Input: We discuss a case with significant progressive peripheral neurological deterioration following administration of both fludarabine and cytarabine as part of the FLA (fludarabine and cytarabine) regime.

following

a case

significant progressive peripheral neurological deterioration

fludarabine and cytarabine

FLA (fludarabine and cytarabine) regime

fludarabine

cytarabine

FLA (fludarabine and cytarabine)

fludarabine

cytarabine


Input: The course of delirium due to lithium intoxication.

due

delirium

lithium intoxication

lithium


Input: Preadmission warfarin use was not associated with any secondary intracerebral hemorrhage (OR, 1.2; 95% CI, 0.7 to 2.2), symptomatic intracerebral hemorrhage (OR, 1.1; 95% CI, 0.5 to 2.3), or gastrointestinal hemorrhage (OR, 1.1; 95% CI, 0.2 to 5.6).

associated

any secondary intracerebral hemorrhage (OR, 1.2; 95% CI, 0.7 to 2.2), symptomatic intracerebral hemorrhage (OR, 1.1; 95% CI, 0.5 to 2.3), or gastrointestinal hemorrhage (OR, 1.1; 95% CI, 0.2 to 5.6)

Preadmission warfarin

warfarin


Input: In this case of a possible drug-drug interaction between IFN alfa 11 MU TIW and gemfibrozil 600 mg BID in a patient undergoing treatment for IFN-induced hypertriglyceridemia, the Naranjo Adverse Drug Reactions (ADR) Probability Scale score was 7 (ie, ADR possibly related to treatment).

Probability

a patient undergoing treatment for IFN-induced hypertriglyceridemia

Naranjo Adverse Drug Reactions

IFN alfa 11 MU TIW

gemfibrozil 600 mg BID

IFN alfa 11

gemfibrozil

600 mg

IFN-induced hypertriglyceridemia

IFN alfa 11

gemfibrozil


Input: Stupor from lamotrigine toxicity.

from

Stupor

lamotrigine

lamotrigine


Input: Autopsy findings were consistent with bleomycin and oxygen-induced pulmonary damage.

induced

pulmonary damage

bleomycin and oxygen

oxygen

bleomycin

oxygen

bleomycin


Input: We report a case of vitiligo that occurred during the second month of interferon alpha 2a therapy for chronic active hepatitis C.

occurred

vitiligo

during the second month of interferon alpha 2a therapy

chronic active hepatitis C.

the second month

interferon alpha 2a


Input: Vardenafil is a new oral phosphodiesterase inhibitor used for erectile dysfunction.

used for

Vardenafil is a new oral phosphodiesterase inhibitor

erectile dysfunction

Vardenafil

oral


Input: CONCLUSION: A patient with CHF and ESRD developed myoclonic muscle spasms after receiving dobutamine by continuous i.v.

after

A patient with CHF and ESRD

ESRD

myoclonic muscle spasms

dobutamine by continuous i.v

dobutamine

continuous

i.v

CHF


Input: Nail-changes induced by penicillamine.

induced

Nail-changes

penicillamine

penicillamine


Input: The fourth patient showed RLS symptoms that were initially caused by a 20-mg daily olanzapine dosage and were later mitigated when olanzapine was reduced and ropinirole was administered.

caused

The fourth patient

RLS symptoms

20-mg daily olanzapine dosage

daily

olanzapine


Input: Naproxen-associated sudden sensorineural hearing loss.

associated

sudden sensorineural hearing loss

Naproxen

Naproxen


Input: Retinoic acid may increase the risk of bone marrow transplant nephropathy.

increase

bone marrow transplant nephropathy

Retinoic acid

Retinoic acid


Input: A review of published case reports showed a short time to onset of symptoms following the introduction of linezolid, generally within 1-3 days.

following

a short time to onset of symptoms

introduction of linezolid, generally within 1-3 days

linezolid

within 1-3 days


Input: Intrathecal chemotherapy with methotrexate or cytosine arabinoside is the standard approach to prophylaxis and treatment of central nervous system leukemia in children.

treatment

children

children

Intrathecal chemotherapy with methotrexate or cytosine arabinoside

central nervous system leukemia

methotrexate

cytosine arabinoside

Intrathecal chemotherapy


Input: The following day, the patient developed anxiety, panic attacks, tremors, tachycardia, and hypertension that persisted throughout linezolid treatment.

developed

patient

anxiety, panic attacks, tremors, tachycardia, and hypertension

linezolid

linezolid


Input: Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review.

induced

premature infants

premature

infants

hypertrophic obstructive cardiomyopathy

dexamethasone

dexamethasone


Input: Although transient increases in ectopy after bretylium therapy have been described, presumably due to catecholamine release, the occurrence of life-threatening ventricular arrhythmia leading to cardiac arrest has not previously been emphasized.

after

transient increases in ectopy

life-threatening ventricular arrhythmia leading to cardiac arrest

bretylium

bretylium


Input: We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.

induced

three cases

three

hepatitis in MS

IFN beta

IFN beta


Input: RTA is one type of nephrotoxicity induced by FK506, and it is reversible in mild cases when appropriately treated.

induced

RTA

nephrotoxicity


Input: The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.

associated

nausea, vomiting, hypotension, hypocalcemia

allergic reactions.

amifostine

amifostine


Input: Nonconvulsive status epilepticus due to ifosfamide.

due

Nonconvulsive status epilepticus

ifosfamide

ifosfamide


Input: Clinical experience in infectious patients has shown that oral telithromycin 800mg once daily for 5-10 days is effective for the treatment of community-acquired upper and lower respiratory tract infections.

treatment

infectious patients

infectious

oral telithromycin 800mg once daily for 5-10 days

telithromycin

once daily

5-10 days

community-acquired upper and lower respiratory tract infections

oral


Input: Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia.

developed

Five patients

Five

akathisia

fluoxetine

fluoxetine


Input: This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to be a new entity.

be

hyperpigmentation

minocycline

minocycline


Input: Phenytoin/isradipine interaction causing severe neurologic toxicity.

causing

neurologic toxicity

Phenytoin/isradipine interaction

Phenytoin

isradipine

isradipine

Phenytoin


Input: We report a case of torsade de pointes following a single oral dose of amiodarone (1400 mg or 30 mg kg-1) administered after short intravenous loading for prevention of paroxysmal atrial flutter.

following

torsade de pointes

a single oral dose of amiodarone (1400 mg or 30 mg kg-1)

single oral dose

1400 mg

30 mg kg-1

amiodarone

prevention of paroxysmal atrial flutter


Input: Traditionally, children with acute lymphoblastic leukemia receive prednisone, as part of multiagent remission-induction chemotherapy.

receive

children with acute lymphoblastic leukemia

children

prednisone

acute lymphoblastic leukemia

prednisone


Input: Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies.

induced

sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies

Propylthiouracil

Propylthiouracil


Input: Acute respiratory depression as a complication of nebulised morphine.

complication

Acute respiratory depression

nebulised morphine

morphine


Input: We report on a patient with an embryonal teratocarcinoma of the testicle who had the syndrome of inappropriate secretion of antidiuretic hormone after receiving a high dose of vinblastine.

had

a patient with an embryonal teratocarcinoma of the testicle

syndrome of inappropriate secretion of antidiuretic hormone

a high dose of vinblastine

high dose

vinblastine

embryonal teratocarcinoma of the testicle


Input: Methotrexate-induced liver cirrhosis.

induced

liver cirrhosis

Methotrexate

Methotrexate


Input: A case of oculogyric crisis induced by metoclopramide is described in this paper.

induced

oculogyric crisis

metoclopramide

metoclopramide


Input: Early-onset acute transverse myelitis following hepatitis B vaccination and respiratory infection: case report.

following

case

Early-onset acute transverse myelitis

hepatitis B vaccination

hepatitis B vaccination


Input: The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway.

of

pro-arrhythmic effects

procainamide

procainamide


Input: We present the management of agranulocytosis and neutropenic sepsis secondary to carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF).

secondary

agranulocytosis and neutropenic sepsis

carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF)

carbimazole

recombinant human granulocyte colony stimulating factor

recombinant human granulocyte colony stimulating factor

carbimazole


Input: Cutaneous mycobacterial infection post intravesical BCG installation.

post

Cutaneous mycobacterial infection

intravesical BCG installation

intravesical


Input: On day 4, following 3 doses of dalteparin, the patient developed acute respiratory distress attributable to a massive right hemothorax confirmed by computed tomography pulmonary angiography (CTPA) and intercostal drainage of 1500 mL of frank blood.

following

the patient

acute respiratory distress attributable to a massive right hemothorax

3 doses of dalteparin

dalteparin

3 doses


Input: A 4-month regimen of gatifloxacin with rifampin, isoniazid, and pyrazinamide is being evaluated for the treatment of tuberculosis in a phase 3 randomized controlled trial (OFLOTUB).

treatment

gatifloxacin

rifampin

isoniazid

pyrazinamide

gatifloxacin

rifampin

isoniazid

pyrazinamide

tuberculosis

isoniazid

pyrazinamide


Input: We postulate that the bolus of sulprostone resulted in possible coronary spasm that resulted in cardiac arrest.

resulted

coronary spasm that resulted in cardiac arrest

sulprostone

sulprostone


Input: A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole.

presented

72-year-old woman with a history of thyrotoxicosis

thyrotoxicosis

woman

sore throat and fever

two weeks after starting carbimazole

carbimazole

two weeks


Input: Without other causes for the hyponatremia, she was diagnosed with the syndrome of inappropriate antidiuretic hormone, presumably caused by desmopressin.

diagnosed

she

she

hyponatremia

syndrome of inappropriate antidiuretic hormone

desmopressin

desmopressin


Input: Fatal peripheral neuropathy following FLA chemotherapy.

following

Fatal peripheral neuropathy

FLA chemotherapy

FLA

chemotherapy


Input: Rhabdomyolysis caused by a potential sitagliptin-lovastatin interaction.

caused

Rhabdomyolysis

potential sitagliptin-lovastatin interaction

sitagliptin

lovastatin

lovastatin

sitagliptin


Input: A 78-year-old man with a history of congestive heart failure and coronary artery disease began taking amiodarone to suppress sustained ventricular tachycardia.

suppress

A 78-year-old man with a history of congestive heart failure and coronary artery disease

man

congestive heart failure

coronary artery disease

amiodarone

amiodarone

sustained ventricular tachycardia


Input: A patient with severe cholestatic jaundice induced by captopril is presented.

induced

A patient

severe cholestatic jaundice

captopril

captopril


Input: Three distinct types of minocycline-induced cutaneous pigmentation have been described.

induced

cutaneous pigmentation

minocycline

minocycline


Input: The occurrence of symptoms that could be ascribed to an acute coronary syndrome should always be taken seriously during the first rituximab infusion and investigated aggressively.

during

acute coronary syndrome

first rituximab infusion

first

rituximab

infusion


Input: Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).

resulted

12th week of pregnancy

pregnancy

elevated hepatic enzymes

propylthiouracil (PTU)

propylthiouracil


Input: Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with propylthiouracil therapy.

associated

Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis

propylthiouracil therapy

propylthiouracil


Input: ADH hypersecretion in relation to plasma osmolality was reversed by mizoribin withdrawal, suggesting that bredinin might adversely induce SIADH.

reversed

plasma osmolality

plasma osmolality

mizoribin withdrawal

ADH hypersecretion

mizoribin


Input: Heparin-induced thrombocytopenia is a rare and serious complication of anticoagulation therapy.

complication

thrombocytopenia

anticoagulation therapy

Heparin


Input: Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.

after

an HIV type 1-infected patient

Iatrogenic Cushing syndrome

receiving therapy with ritonavir-lopinavir

epidural triamcinolone injections

HIV type 1

epidural triamcinolone

ritonavir-lopinavir

injections

epidural triamcinolone

ritonavir-lopinavir


Input: Otolaryngologists should be made aware of a newer cause of nasal septal perforations resulting from the more recent antiangiogenic therapy used to treat malignancies.

resulting

nasal septal perforations

the more recent antiangiogenic therapy

the more recent antiangiogenic therapy

malignancies


Input: Following several of these courses of therapy, respiratory distress occurred 9 to 12 days after the chlorambucil was given.

after

respiratory distress

the chlorambucil

9 to 12 days

chlorambucil


Input: Possible mechanisms for damage to the urothelium by ketamine are suggested.

by

damage to the urothelium

ketamine

ketamine


Input: Persistent hypoglycemia in a patient with diabetes taking etanercept for the treatment of psoriasis.

taking

a patient with diabetes

diabetes

Persistent hypoglycemia

etanercept

etanercept

psoriasis


Input: Cutaneous necrosis after injection of polyethylene glycol-modified interferon alfa.

after

Cutaneous necrosis

injection of polyethylene glycol-modified interferon alfa

polyethylene glycol-modified interferon alfa.

injection


Input: We report an unusual case of simultaneous transitional cell carcinoma of the renal pelvis and distal ureter without transitional cell carcinoma of the bladder occurring after chronic cyclophosphamide therapy for nonHodgkin's lymphoma.

after

simultaneous transitional cell carcinoma of the renal pelvis and distal ureter without transitional cell carcinoma of the bladder

chronic cyclophosphamide therapy

cyclophosphamide

nonHodgkin's lymphoma

chronic


Input: In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine.

treatment

two patients with active UC

two

severe systemic CMV infection

oral microemulsion form of cyclosporine

oral

cyclosporine

active UC


Input: Prior to surgery, the patient received droperidol, an agent known to prolong the QT interval.

received

the patient

droperidol

Prior to surgery

droperidol


Input: OBJECTIVE: We report a case of cutaneous KS lesions in a patient affected by CML treated with imatinib.

treated with

a patient affected by CML

cutaneous KS lesions

imatinib

imatinib

CML


Input: The FK 506 dose was constant within 21 days after discontinuing phenytoin in Patient 1 who had 36 days of phenytoin therapy.

discontinuing

Patient 1

The FK 506 dose was constant within 21 days

phenytoin

phenytoin

phenytoin therapy

36 days


Input: In patients receiving antithrombin III and concomitant heparin, a significantly increased bleeding incidence was observed (23.8% for antithrombin III group vs 13.5% for placebo group; P<.001).

increased

patients

bleeding incidence

antithrombin III and concomitant heparin

concomitant heparin

antithrombin III

antithrombin III

concomitant heparin


Input: Bone marrow chromosomes were studied in 2 patients with polycythaemia vera (PV) at the time of diagnosis and several times subsequently during therapy with chlorambucil.

therapy

2 patients with polycythaemia vera (PV)

chlorambucil

polycythaemia vera (PV)

chlorambucil


Input: Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.

induced

incessant supraventricular tachycardia

Procainamide

Wolff-Parkinson-White syndrome

Procainamide


Input: To our knowledge, however, this is the first case report of a possible sitagliptin-lovastatin interaction that may have caused rhabdomyolysis.

caused

rhabdomyolysis

sitagliptin-lovastatin interaction

sitagliptin

lovastatin

lovastatin

sitagliptin


Input: A drug addict with staphylococcal endocarditis treated with methicillin, who developed massive proteinuria and acute nephritic syndrome is described.

developed

A drug addict

drug addict

massive proteinuria and acute nephritic syndrome

methicillin

staphylococcal endocarditis

methicillin


Input: Although inhibition of the angiotensin-converting enzyme is considered to be efficient treatment for hypertension associated with chronic renal failure, care should be taken when captopril is administered initially to a patient with decreased renal function, under the conditions of sodium and water depletion.

treatment

a patient with decreased renal function

decreased renal function

captopril

hypertension associated with chronic renal failure

captopril


Input: Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT.

after

Two patients

Two

extrapyramidal side effects

fluphenazine decanoate

fluphenazine decanoate


Input: The clinical course suggests that the interstitial pneumonitis was induced by hydroxyurea.

induced

interstitial pneumonitis

hydroxyurea

hydroxyurea


Input: Disulfiram-induced hepatitis.

induced

hepatitis

Disulfiram

Disulfiram


Input: The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.

attributed

radiation recall reactions

gemcitabine

gemcitabine


Input: The known side effects of sibutramine, ie, hypertension and tachycardia, depend on its adrenergic and serotoninergic effects.

of

hypertension and tachycardia

sibutramine

sibutramine


Input: Because at the end of the first month the patient's platelet counts were normal and the thrombocytopenia developed after the co-medication with conventional drugs, it was suspected that the thrombocytopenia might not be attributed to the use of FHP.

attributed

thrombocytopenia

FHP

FHP


Input: Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described.

induced

Two cases of childhood-onset schizophrenia

Two

childhood

akathisia responsive

clozapine

clozapine

schizophrenia


Input: Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.

following

a pulmonary adenocarcinoma patient with a malignant pleural effusion

malignant pleural effusion

Syndrome of inappropriate secretion of ADH (SIADH)

cisplatin

pulmonary adenocarcinoma

cisplatin


Input: He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.

during

hypersensitivity reaction

with diffuse urticaria, facial swelling, cough, and chest tightness

MTX infusion

immediate

MTX

infusion


Input: CONCLUSIONS: We present a case of a patient with CML who developed KS 12 months after starting treatment with imatinib 400 mg/d.

developed

a patient

KS

12 months

imatinib 400 mg/d

12 months

imatinib

400 mg/d


Input: Grade 3 hepatotoxicity (AST and ALT > 5 to 20 upper limit normal) or higher has been observed in as many as 1.4% of MS patients on IFN beta.

observed

1.4% of MS patients

Grade 3 hepatotoxicity

IFN beta

IFN beta

MS


Input: The second patient was a girl of 6, already on risperidone for ADHD and borderline intellectual functioning when referred.

on

a girl of 6

girl

risperidone

risperidone

ADHD

borderline intellectual functioning


Input: To report a young man on phenytoin who developed acute neurologic symptoms after isradipine was introduced to his treatment regimen and discuss the possible causes of this drug interaction.

developed

a young man

young

man

acute neurologic symptoms

phenytoin

isradipine

isradipine

phenytoin

phenytoin

isradipine


Input: Reversible sirolimus-associated pneumonitis after heart transplantation.

associated

pneumonitis

sirolimus

sirolimus


Input: We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA).

induced

a girl

girl

Rett syndrome

acute encephalopathy

calcium hopantenate (HOPA)

calcium hopantenate


Input: Only after three subsequent episodes of severe, symptomatic thrombocytopenia over the next four weeks did he say, upon repeat questioning, that he had continued to take quinine for night leg cramps.

take

he

night leg cramps

he

symptomatic thrombocytopenia

continued to take quinine

quinine

night leg cramps

over the next four weeks


Input: An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.

after

a young adult with metastastic gastric cancer

young adult

subacute encephalopathy

a moderate dose of methotrexate (1500 mg/m2) (MTX)

1500 mg/m2

methotrexate

metastastic gastric cancer


Input: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.

treated

hepatitis C virus infected patient

Rhabdomyolysis

telaprevir and simvastatin

telaprevir

simvastatin

hepatitis C virus

telaprevir

simvastatin


Input: Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.

complaints

patient

carpopedal spasm and bronchospasm

Four days after intravenous Zoledronic acid

Four days after

intravenous

Zoledronic acid


Input: Ulcerating enteritis associated with flucytosine therapy.

associated with

Ulcerating enteritis

flucytosine therapy

flucytosine


Input: OBJECTIVES: To describe clinical and pathologic findings in patients noted to develop lower gastrointestinal symptoms when exposed to rofecoxib.

develop

patients

lower gastrointestinal symptoms

rofecoxib

rofecoxib


Input: Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and, in some patients with CML, imatinib may promote cytogenetic clonal evolution, resulting in a poor response to treatment.

during

significant progression of marrow reticulin fibrosis

imatinib

imatinib


Input: Metabolic acidosis induced by cetrimide-chlorhexidine solution in hydatid cyst surgery.

induced

Metabolic acidosis

cetrimide-chlorhexidine solution

hydatid cyst

cetrimide

chlorhexidine

solution

chlorhexidine

cetrimide


Input: Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF).

induced

granulocyte colony-stimulating factor

neutropenia

gold

granulocyte colony-stimulating factor (G-CSF)

gold


Input: Methyldopa-induced liver injury.

induced

liver injury

Methyldopa

Methyldopa


Input: After infliximab treatment, additional sleep studies revealed an increase in the number of apneic events and SaO2 dips suggesting that TNFalpha plays an important role in the pathophysiology of sleep apnea.

increase

increase in the number of apneic events and SaO2 dips

infliximab

pathophysiology of sleep apnea

infliximab


Input: One patient developed severe hyponatremia with serum Na+ of 108 mEq/L when hydrochlorothiazide was given to control hypertension.

developed

One patient

One

severe hyponatremia with serum Na+ of 108 mEq/L

hydrochlorothiazide

hypertension

hydrochlorothiazide


Input: Thyroid dysfunction has been reported in patients with malignant disease treated with recombinant alpha interferon.

reported

patients with malignant disease

Thyroid dysfunction

recombinant alpha interferon

malignant disease

recombinant alpha interferon


Input: The authors also determined that their case of myositis developing in the rectus abdominus muscle of a patient with pancreatic adenocarcinoma was the manifestation of radiation recall, thereby bringing the number of patients who developed radiation recall to gemcitabine and were discussed in the current study to 13.

developed

a patient with pancreatic adenocarcinoma

myositis developing in the rectus abdominus muscle

radiation recall

gemcitabine

pancreatic adenocarcinoma

gemcitabine


Input: Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia.

triggered

severe thrombocytopenia

quinine tablet

quinine

tablet


Input: Case 1 presented after 25 months of myelosuppressive therapy a deletion of chromosome no. 12, del (12) (p11), in 60% of the diploid cells.

after

Case 1

a deletion of chromosome no. 12, del (12) (p11), in 60% of the diploid cells

25 months of myelosuppressive therapy

25 months

myelosuppressive


Input: Diabetes Mellitus was observed in a patient given carbamazepine.

given

a patient

Diabetes Mellitus

carbamazepine

carbamazepine


Input: Anxiety is common in patients with schizophrenia and pregabalin has been suggested as an off-label add-on treatment.

treatment.

patients with schizophrenia

schizophrenia

pregabalin has been suggested as an off-label add-on treatment

pregabalin

Anxiety


Input: Large cerebral infarction during praziquantel therapy in neurocysticercosis.

during

Large cerebral infarction

praziquantel

praziquantel

neurocysticercosis


Input: We report a 13 year-old male who developed life-threatening anaphylaxis early in the course of Increlex therapy.

developed

a 13 year-old male

13 year-old

anaphylaxis

Increlex

Increlex


Input: Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis.

secondary

liver injury

interferon-beta (IFN-beta)

interferon-beta

multiple sclerosis


Input: CONCLUSION: Lipoid pneumonia as a result of mineral oil aspiration still occurs in the pediatric population.

result

pediatric

pediatric

Lipoid pneumonia

mineral oil aspiration

mineral oil


Input: The results from the present study suggest that tissue plasminogen activator treatment appears to be safe in patients with acute ischemic stroke taking warfarin with an international normalized ratio <1.7 and may reduce the risk of poor functional outcome.

appears

patients with acute ischemic stroke

may reduce the risk of poor functional outcome

taking warfarin with an international normalized ratio <1.7

tissue plasminogen activator treatment

acute ischemic stroke

tissue plasminogen activator

warfarin

tissue plasminogen activator

warfarin


Input: Because of chronic asthma, she had been receiving a leukotriene receptor antagonist (montelukast) for 5 years before the current presentation; 1 week before onset she had had 1 week of treatment with two dietary supplements for weight control; one of these included Garcinia Cambogia, a possible cause of two recent cases of hepatitis in the USA; in addition, both formulas contained a citrus derivative that interferes cytochrome functions.

receiving

she

a leukotriene receptor antagonist (montelukast) for 5 years

chronic asthma

montelukast

5 years


Input: An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.

after

13-year-old girl who

girl

leukoencephalopathy

standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate

radiotherapy

methotrexate

intrathecal methotrexate

infusion

500 mg/m2

12 mg


Input: BACKGROUND: Accutane a teratogenic prescription drug licensed to treat severe, recalcitrant nodular acne.

treat

Accutane

severe, recalcitrant nodular acne

Accutane


Input: OBJECTIVE: To report the safe use of fluorouracil in a patient with breast cancer who had allergic reactions to capecitabine.

safe

a patient with breast cancer who had allergic reactions to capecitabine

allergic reactions to capecitabine

fluorouracil

fluorouracil

breast cancer


Input: Esophageal candidiasis following omeprazole therapy: a report of two cases.

following

two cases

two

Esophageal candidiasis

omeprazole

omeprazole


Input: We describe a 10-year-old boy with ulcerative colitis who developed acute pancreatitis while on long-term treatment with 5-aminosalicylic acid.

developed

a 10-year-old boy with ulcerative colitis

boy

acute pancreatitis

long-term treatment with 5-aminosalicylic acid

long-term treatment

5-aminosalicylic acid

ulcerative colitis


Input: The mechanism of niacin-induced coagulopathy is theorized to be related to diminished coagulation factors, and limited data suggest that this may be more pronounced with extended-release niacin.

induced

coagulopathy

niacin

niacin

extended-release niacin


Input: OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide.

following

nonconvulsive status epilepticus (NCSE)

infusion of ifosfamide

infusion

ifosfamide


Input: We conclude that the observed toxicity with jaundice was probably caused by an interaction of this popular Chinese formula and temozolomide.

caused

toxicity with jaundice

temozolomide

temozolomide


Input: Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.

adverse

Pigmentary disorders

semi-synthetic tetracycline derivative antibiotic, minocycline

minocycline


Input: Pregabalin is an antiepileptic drug with anti-anxiety properties and is approved for treatment of generalized anxiety disorder.

treatment

Pregabalin is an antiepileptic drug with anti-anxiety properties

Pregabalin

generalized anxiety disorder


Input: We report a case of chronic use of HCQ associated with torsade de pointes.

associated

torsade de pointes

chronic use of HCQ

HCQ

chronic


Input: PURPOSE: The occurrence of myoclonus associated with continuous i.v. infusion of dobutamine in a patient with end-stage renal disease (ESRD) is described.

associated with

a patient with end-stage renal disease (ESRD)

end-stage renal disease (ESRD)

myoclonus

continuous i.v. infusion of dobutamine

dobutamine

infusion


Input: The case concerns the sudden death of a 29-year-old male during clozapine therapy started 2 weeks before.

during

a 29-year-old male

male

sudden death

clozapine

clozapine

2 weeks before


Input: In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination.

developed

3 years-old boy

3 years-old

boy

a viral respiratory infecction

acute onset tetraparesia

hepatitis B vaccination

hepatitis B vaccination


Input: Treatment of ELP in children is generally supportive, with the symptoms and roentgenographic abnormalities resolving within months after stopping the use of mineral oil.

after

symptoms and roentgenographic abnormalities resolving

stopping the use of mineral oil

mineral oil

ELP


Input: PET scintigraphy of etoposide-induced pulmonary toxicity.

induced

pulmonary toxicity

etoposide

etoposide


Input: We report a patient who experienced LABD shortly after starting carbamazepine therapy.

after

a patient

experienced LABD shortly

starting carbamazepine therapy

carbamazepine

starting


Input: Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene.

induced

neuroleptic malignant syndrome

Fulminant metoclopramide

metoclopramide


Input: Can ketamine prescribed for pain cause damage to the urinary tract?

cause

damage to the urinary tract

ketamine

pain

ketamine


Input: Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF).

suspended

congestive heart failure (CHF)

IFN

IFN


Input: We believe this is the first report of myocardial infarction due to coronary spasm, demonstrated by angiography associated with L-thyroxine therapy.

associated

myocardial infarction

coronary spasm

L-thyroxine

L-thyroxine


Input: A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.

developed

58-year-old woman with rheumatoid arthritis (RA)

woman

fever, skin eruptions, leukocytopenia, and thrombocytopenia

3 weeks after treatment with sulfasalazine

sulfasalazine

3 weeks after

rheumatoid arthritis (RA)


Input: Gold-induced aplastic anemia.

induced

aplastic anemia

Gold

Gold


Input: One patient developed large intramural esophageal hematoma as a complication of heparin therapy.

developed

One patient

large intramural esophageal hematoma

a complication of heparin therapy

heparin


Input: Mammary gigantism is a rare complication of D-penicillamine treatment.

complication of

Mammary gigantism

D-penicillamine treatment

D-penicillamine


Input: Cyclobenzaprine shares anticholinergic effects, tachycardia, and dysrhythmic potential with the tricyclic antidepressants (TCAs).

potential

anticholinergic effects, tachycardia, and dysrhythmic

Cyclobenzaprine

with the tricyclic antidepressants (TCAs)

Cyclobenzaprine

tricyclic antidepressants


Input: The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.

induced

hypersensitivity myocarditis

death

clozapine

clozapine


Input: PURPOSE: To present a case of respiratory depression following the administration of nebulised morphine.

following

respiratory depression

nebulised morphine

morphine

nebulised


Input: METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.

became

A 55-year-old woman

woman

stuporous

overdose with lamotrigine (LTG) and valproic acid (VPA) tablets

overdose

lamotrigine

valproic acid

tablets

lamotrigine

valproic acid


Input: Recrudescence of imported falciparum malaria after quinine therapy: potential drug interaction with phenytoin.

after

Recrudescence of imported falciparum malaria

quinine

phenytoin

quinine

phenytoin

phenytoin

quinine


Input: CONCLUSIONS: Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent.

association

thrombocytopenia

lansoprazole

lansoprazole


Input: One of the subjects who was using extemporaneous topical minoxidil had hypertension and arteriosclerotic disease and the other died of a myocardial infarction.

had

One of the subjects

One

hypertension and arteriosclerotic disease

extemporaneous topical minoxidil

topical

minoxidil


Input: CONCLUSION: Long-term treatment with rifabutin may have a reversible and previously undescribed side-effect on retinal function.

have

side-effect on retinal function

rifabutin

rifabutin


Input: Toxic hepatitis due to combination therapy with methotrexate and etretinate in psoriasis.

due

Toxic hepatitis

methotrexate and etretinate

methotrexate

etretinate

psoriasis

methotrexate

etretinate


Input: To report the results of therapeutic drug monitoring of lopinavir/ritonavir and itraconazole concentrations in an HIV-infected male who was treated for histoplasmosis.

treated

an HIV-infected male

male

lopinavir/ritonavir and itraconazole concentrations

histoplasmosis

HIV

itraconazole

ritonavir

lopinavir

lopinavir

ritonavir

itraconazole


Input: Ulcer became worse after tobramycin and gentamycin treatment for 2 days.

after

Ulcer became worse

tobramycin and gentamycin

Ulcer

tobramycin

gentamycin

gentamycin

tobramycin


Input: Thalidomide has proven activity in refractory multiple myeloma (MM), and although single-agent thalidomide has minimal prothrombogenic activity, its combination with cytotoxic chemotherapy is associated with a significantly increased risk of DVT.

associated

significantly increased risk of DVT

single-agent thalidomide

combination with cytotoxic chemotherapy

refractory multiple myeloma (MM)

thalidomide

cytotoxic

chemotherapy

thalidomide

cytotoxic


Input: These cases indicate that sulpiride can cause tardive dyskinesia and that this drug should be administered with caution.

cause

tardive dyskinesia

sulpiride

sulpiride


Input: Well-differentiated endometrial adenocarcinoma of the secretory type (FIGO Grade 1) with minimal myometrial invasion occurred in a postmenopausal patient on tamoxifen therapy 5 years after mastectomy for breast carcinoma.

occurred

a postmenopausal patient

postmenopausal

Well-differentiated endometrial adenocarcinoma of the secretory type (FIGO Grade 1) with minimal myometrial invasion

tamoxifen therapy 5 years after mastectomy for breast carcinoma.

tamoxifen

breast carcinoma


Input: Secondary hematologic neoplasm after intravesical chemotherapy for superficial bladder carcinoma.

after

Secondary hematologic neoplasm

intravesical chemotherapy

bladder carcinoma

intravesical

chemotherapy


Input: Ciprofloxacin-induced renal insufficiency in cystic fibrosis.

induced

renal insufficiency

Ciprofloxacin

Ciprofloxacin

cystic fibrosis


Input: While the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity has been shown to be a beneficial therapy for malignant glioma, it is recognized that clinically significant cerebral edema is a potential adverse effect.

adverse

significant cerebral edema

the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity

malignant glioma

carmustine wafers


Input: Didanosine also has a potential for inducing seizures.

inducing

seizures

Didanosine

Didanosine


Input: Obsessive-compulsive symptoms suddenly emerged 10 days after starting risperidone and resolved within 3 days of discontinuation.

emerged

Obsessive-compulsive symptoms

risperidone

risperidone


Input: Refractory hypoglycemia from ciprofloxacin and glyburide interaction.

from

Refractory hypoglycemia

ciprofloxacin and glyburide interaction

ciprofloxacin

glyburide

glyburide

ciprofloxacin


Input: Anaphylactic reaction to recombinant insulin-like growth factor-I.

to

Anaphylactic reaction

recombinant insulin-like growth factor-I.

recombinant insulin-like growth factor-I.


Input: Subtherapeutic warfarin is not associated with increased hemorrhage rates in ischemic strokes treated with tissue plasminogen activator.

associated

increased hemorrhage rates

Subtherapeutic warfarin

treated with tissue plasminogen activator

ischemic strokes

tissue plasminogen activator

warfarin

warfarin

tissue plasminogen activator


Input: Pediatric heparin-induced thrombocytopenia: management with Danaparoid (orgaran).

management

Pediatric

Pediatric

Danaparoid (orgaran)

heparin-induced thrombocytopenia

Danaparoid


Input: Teicoplanin-induced agranulocytosis that followed vancomycin-induced agranulocytosis suggests a possible cross-reactivity between the 2 drugs.

induced

agranulocytosis

Teicoplanin

followed vancomycin

Teicoplanin

vancomycin

Teicoplanin

vancomycin


Input: A 55-year-old woman developed symptoms suggestive of hepatitis 12 weeks after first receiving methyldopa for hypertension.

developed

A 55-year-old woman

woman

hepatitis

methyldopa

hypertension

12 weeks

methyldopa


Input: Cyclophosphamide can rarely cause interstitial pneumonitis and fibrosis.

cause

interstitial pneumonitis and fibrosis

Cyclophosphamide

Cyclophosphamide


Input: Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug.

associated

6%-10% of patients

diarrhea

Flucytosine

Flucytosine


Input: IV propranolol was used as the initial treatment for his hyperadrenergic state, resulting in a decrease in heart rate but a paroxsymal increase in blood pressure.

resulting

his hyperadrenergic state

his

decrease in heart rate but a paroxsymal increase in blood pressure

IV propranolol

propranolol

hyperadrenergic state

IV


Input: We believe that this is the first report of secretory carcinoma of the endometrium associated with tamoxifen use.

associated

secretory carcinoma of the endometrium

tamoxifen

tamoxifen


Input: Herpes simplex esophagitis in a renal transplant patient treated with cyclosporine A: a case report.

treated

renal transplant patient

Herpes simplex esophagitis

cyclosporine

cyclosporine

renal transplant


Input: This clinical course suggests that the sensorimotor polyneuropathy may have been caused by 5-ASA.

caused

sensorimotor polyneuropathy


Input: Spontaneous nasal septal perforation with antiangiogenic bevacizumab therapy.

with

Spontaneous nasal septal perforation

antiangiogenic bevacizumab therapy

bevacizumab


Input: There are a few case reports on hair loss associated with tricyclic antidepressants and serotonin selective reuptake inhibitors (SSRIs), but none deal specifically with paroxetine.

associated

hair loss

tricyclic antidepressants and serotonin selective reuptake inhibitors

tricyclic antidepressants

serotonin selective reuptake inhibitors

tricyclic antidepressants

serotonin selective reuptake inhibitors


Input: There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin.

with

more than 20 observations of the appearance or aggravation of this granulomatosis

interferon alfa and more recently with the combination of interferon alfa plus ribavirin

interferon alfa

interferon alfa

ribavirin

interferon alfa

ribavirin


Input: CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.

developed

A 37-year-old African- American man with G6PD deficiency

G6PD deficiency

African- American

man

hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis

trimethoprim-sulfamethoxazole

trimethoprim-sulfamethoxazole


Input: All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.

induced

focal myositis, synovitis, and mononeuritis

All-trans retinoic acid

All-trans retinoic acid


Input: Oxygen potentiation of bleomycin-induced pulmonary toxicity is discussed.

induced

pulmonary toxicity

Oxygen potentiation of bleomycin

Oxygen

bleomycin

bleomycin

Oxygen


Input: CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.

result

reversible encephalopathy

LTG overdose

LTG

overdose


Input: In this report, we describe a case of rhabdomyolysis and acute renal failure secondary to the interaction between danazol and simvastatin.

secondary

rhabdomyolysis and acute renal failure

interaction between danazol and simvastatin

danazol

simvastatin

danazol

simvastatin


Input: Infectious toxicity of dexamethasone during all remission-induction chemotherapy: report of two cases and literature review.

during

two cases

two

Infectious toxicity

dexamethasone

all remission-induction chemotherapy

dexamethasone

chemotherapy


Input: A 56-year-old white male had been receiving chronic warfarin therapy for 11 years after mechanical heart valve replacement.

receiving

A 56-year-old white male

white

male

chronic warfarin therapy for 11 years after mechanical heart valve replacement

warfarin


Input: Isoniazid associated, painful, bilateral gynaecomastia.

associated,

painful, bilateral gynaecomastia

Isoniazid

Isoniazid


Input: Electrocardiographic findings and laboratory data indicated a diagnosis of acute myocardial infarction due to the L-thyroxine therapy.

due to

acute myocardial infarction

the L-thyroxine therapy.

L-thyroxine


Input: Combining methylephedrine and Chinese herbal drugs might carry a risk of stroke.

carry

risk of stroke

Combining methylephedrine and Chinese herbal drugs

methylephedrine

Chinese herbal drugs

methylephedrine

Chinese herbal drugs


Input: Coadministration of 200 mg bid voriconazole with 400 mg (or higher) qd efavirenz is contraindicated due to the clinically significant effect of efavirenz on voriconazole pharmacokinetics.

contraindicated

clinically significant effect

Coadministration of 200 mg bid voriconazole with 400 mg (or higher) qd efavirenz

efavirenz on voriconazole

200 mg

400 mg

voriconazole

efavirenz

efavirenz

voriconazole

voriconazole

efavirenz


Input: An interaction between niacin and warfarin likely elevated the INR in this patient because of synergistic coagulopathy and pharmacokinetic effects of niacin.

elevated

this patient

elevated the INR

interaction between niacin and warfarin

niacin

warfarin

niacin

warfarin


Input: We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously.

administration

two cases in which both patients suffered with CLS

two

CLS

granulocyte colony-stimulating factor

granulocyte colony-stimulating factor


Input: Capecitabine was discontinued and the allergic reactions resolved after the woman took diphenhydramine for 1 week.

took

woman

woman

Capecitabine was discontinued and the allergic reactions resolved

diphenhydramine for 1 week

diphenhydramine

1 week


Input: Intravenous fluconazole 400 mg, followed by 100 mg every 24 hours according to impaired renal function, was immediately started; to avoid further nephrotoxicity, immunosuppressant therapy was switched from cyclosporine plus mycophenolate mofetil to oral everolimus 0.75 mg every 12 hours.

avoid

Intravenous fluconazole 400 mg, followed by 100 mg every 24 hours

immunosuppressant therapy was switched from cyclosporine plus mycophenolate mofetil to oral everolimus 0.75 mg every 12 hours

nephrotoxicity

oral

Intravenous

everolimus

mycophenolate mofetil

cyclosporine

fluconazole

0.75 mg every 12 hours

400 mg, followed by 100 mg every 24 hours

cyclosporine

mycophenolate mofetil

fluconazole

everolimus


Input: We report 3 patients with severe hepatocellular damage due to CPA therapy, 2 with fatal fulminant hepatitis.

due

3 patients

severe hepatocellular damage

CPA

CPA


Input: Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.

developed

she

she

anasarca, including marked peripheral oedema, ascites and pleural effusion

insulin

insulin


Input: We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia.

induced

a continuous ambulatory peritoneal dialysis (CAPD) patient

continuous ambulatory peritoneal dialysis (CAPD)

agranulocytosis

vancomycin

methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia

vancomycin


Input: In both cases, we believe that serotonin syndrome was produced by a combination of an antidepressant and an atypical antipsychotic.

produced

In both cases

both

serotonin syndrome

a combination of an antidepressant and an atypical antipsychotic

antidepressant

atypical antipsychotic

antidepressant

atypical antipsychotic


Input: Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.

side effects

hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.

Cyclosporin

Cyclosporin


Input: She displayed severe hyperactivity, agitation and irritability upon switching to methylphenidate medication.

displayed

hyperactivity, agitation and irritability

switching to methylphenidate

methylphenidate


Input: To date, only three cases of seizures associated with amphotericin B have been reported in the literature, but healthcare providers should be aware of the potential for this rare adverse effect.

associated

three cases

three

seizures

amphotericin B

amphotericin B


Input: Heparin-induced thrombocytopenia complicated with massive thrombosis of the inferior vena cava after filter placement.

induced

thrombocytopenia complicated with massive thrombosis of the inferior vena cava after filter placement

Heparin

Heparin


Input: Pharmacokinetics of methadone in human-immunodeficiency-virus-infected patients receiving nevirapine once daily.

receiving

human-immunodeficiency-virus-infected patients

methadone

nevirapine once daily

human-immunodeficiency-virus

once daily

nevirapine

methadone

nevirapine

methadone


Input: Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.

developed

Three patients

Three

severe aplastic anemia

gold salt

rheumatoid arthritis

gold salt


Input: A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non-haemorrhagic hypovolaemia is presented, with a discussion on the management and the use of allergy identification jewellery.

reaction

patient with non-haemorrhagic hypovolaemia

anaphylactoid

Gelofusine

non-haemorrhagic hypovolaemia

Gelofusine


Input: Nonoliguric acute renal failure after captopril therapy.

after

Nonoliguric acute renal failure

captopril

captopril


Input: We report a patient with type 2 diabetes mellitus who, while treated with the antitumor necrosis factor-alpha blocking agent etanercept for severe plaque psoriasis, experienced persistent hypoglycemia requiring the lowering and eventual elimination of his previous insulin regimen.

treated

a patient with type 2 diabetes mellitus

persistent hypoglycemia

the antitumor necrosis factor-alpha blocking agent etanercept

previous insulin regimen

type 2 diabetes mellitus

severe plaque psoriasis

etanercept

insulin

insulin

etanercept


Input: We report the first case of doxycycline-induced hypoglycemia in a young nondiabetic man.

induced

a young nondiabetic man

young

nondiabetic

man

hypoglycemia

doxycycline

doxycycline


Input: The time course of events suggested that amphotericin B was the cause of the seizures in this AIDS patient.

cause

AIDS patient

AIDS

seizures

amphotericin B

amphotericin B


Input: Focal glomerulonephritis and interstitial nephritis in methicillin-treated, heroin-related infective endocarditis.

related

infective endocarditis

heroin

heroin


Input: Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan.

from

Allergic contact dermatitis


Input: We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment.

with

a 5-year-old girl

girl

recovery of vincristine induced cranial polyneuropathy

pyridoxine and pyridostigmine treatment

pyridoxine

pyridostigmine

pyridostigmine

pyridoxine


Input: Lipoid pneumonia: a silent complication of mineral oil aspiration.

of

Lipoid pneumonia

mineral oil aspiration

mineral oil


Input: Elevated serum triglycerides with clozapine resolved with risperidone in four patients.

resolved

four patients

four

risperidone

Elevated serum triglycerides with clozapine

risperidone


Input: Seizures associated with fluoxetine therapy.

associated with

Seizures

fluoxetine therapy

fluoxetine


Input: Sustained monomorphic ventricular tachycardia after adenosine infusion.

after

Sustained monomorphic ventricular tachycardia

adenosine infusion.

adenosine

infusion


Input: A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis.

developed

A 9-year-old boy

boy

acute renal failure

intravenous acyclovir

herpetic encephalitis

intravenous acyclovir

30 mg/kg

per day

6 days


Input: We report a 4-year-old girl who presented with acute bilateral blindness, a focal seizure and hypertension 10 days after commencing oxybutynin to treat enuresis.

after

a 4-year-old girl

girl

acute bilateral blindness, a focal seizure and hypertension

oxybutynin

10 days

oxybutynin

enuresis


Input: Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: first case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter 2.

result

a patient with renal insufficiency

renal insufficiency

Severe arrhythmia

interaction of cetirizine and pilsicainide

cetirizine

pilsicainide

cetirizine

pilsicainide


Input: Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery.

developed

three children

three

children

paraparesis

intrathecal methotrexate

methotrexate

intrathecal


Input: We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine.

given

2 patients who presented to the emergency department with pre-excited atrial fibrillation

ventricular fibrillation

12 mg of adenosine

pre-excited atrial fibrillation

12 mg

adenosine


Input: During administration of chemotherapy, the patient progressively developed a complex association of Beau's lines, transverse melanonychia, Muehrcke's lines, and diffuse hyperpigmentation of the skin.

developed

patient

a complex association of Beau's lines, transverse melanonychia, Muehrcke's lines, and diffuse hyperpigmentation of the skin

chemotherapy

chemotherapy


Input: Distinct patterns of chromonychia, Beau's lines, and melanoderma seen with vincristine, adriamycin, dexamethasone therapy for multiple myeloma.

seen

Distinct patterns of chromonychia, Beau's lines, and melanoderma

vincristine, adriamycin, dexamethasone

vincristine

adriamycin

dexamethasone

multiple myeloma


Input: Theophylline intoxication mimicking diabetic ketoacidosis in a child.

in

a child

child

Theophylline intoxication

Theophylline

Theophylline


Input: We describe a patient who, after receiving his first dose of pregabalin to relieve neuropathic pain, presented with a negative myoclonus.

presented

a patient

negative myoclonus

pregabalin

neuropathic pain

pregabalin


Input: CONCLUSIONS: The use of fluorouracil treatment with careful monitoring can be considered in a patient with mild allergic reactions to capecitabine.

can be considered

a patient with mild allergic reactions to capecitabine

allergic reactions to capecitabine

fluorouracil treatment with careful monitoring

fluorouracil


Input: Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma.

associated

patients with multiple myeloma

Symptomatic hypocalcaemia and renal impairment

bisphosphonate treatment

bisphosphonate

multiple myeloma


Input: Although this G-CSF-driven leucocytosis was alarming it did not appear to have adversely affected the patient's prognosis.

driven

leucocytosis

G-CSF

G-CSF


Input: A case of pyridoxine-dependent seizures is reported.

dependent

A case

seizures

pyridoxine

pyridoxine


Input: A case of a 53-year-old man who developed acute pneumonitis after bleomycin and moderate oxygen administration is presented.

after

A case of a 53-year-old man

man

acute pneumonitis

bleomycin and moderate oxygen

bleomycin

oxygen

moderate

bleomycin

oxygen


Input: Renal tubular acidosis secondary to FK506 in living donor liver transplantation: a case report.

secondary

a case

Renal tubular acidosis


Input: Retinopathy in hepatitis C patients due to combination therapy with pegylated interferon and ribavirin.

due

hepatitis C patients

Retinopathy

pegylated interferon and ribavirin

hepatitis C

pegylated interferon

ribavirin

pegylated interferon

ribavirin


Input: After excluding other causes of long QT syndrome, the HCQ was suspected as the cause of her ventricular tachycardia.

suspected

her

her

ventricular tachycardia

HCQ

HCQ


Input: Phantom limb pain as a manifestation of paclitaxel neurotoxicity.

manifestation

Phantom limb pain

paclitaxel

paclitaxel


Input: A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.

of

a black African

black African

hypersensitivity

allopurinol

allopurinol


Input: Ramipril was stopped and he required a course of steroids after which the rash improved slowly.

improved

he

he

the rash improved slowly

a course of steroids

rash

a course

steroids


Input: Late development of diabetes mellitus after interferon-alfa and ribavirin therapy for chronic hepatitis C: a case report.

after

diabetes mellitus

interferon-alfa

ribavirin

chronic hepatitis C

ribavirin

interferon-alfa

ribavirin

interferon-alfa


Input: Second cancers including various types of hematological malignancy have been reported in patients with hairy cell leukemia treated with chemotherapy or interferon alfa.

reported

patients with hairy cell leukemia

Second cancers including various types of hematological malignancy

chemotherapy or interferon alfa

hairy cell leukemia

interferon alfa

chemotherapy


Input: A patient with a large hydatid cyst of the left lobe of the liver developed metabolic acidosis following rather liberal use of cetrimide-chlorhexidine solution as a scolicidal agent.

developed

A patient with a large hydatid cyst of the left lobe of the liver

a large hydatid cyst of the left lobe of the liver

metabolic acidosis

rather liberal use of cetrimide-chlorhexidine solution as a scolicidal agent

cetrimide-chlorhexidine

rather liberal use

a scolicidal agent


Input: INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B.

received

five pediatric patients

five

pediatric

Cardiac complications

between 4.6 and 40.8 mg/kg/d of amphotericin B.

4.6 and 40.8 mg/kg/d

amphotericin B.


Input: In this case report, we have described a patient with Crohn's disease who developed subfulminant hepatitis B after the fourth infusion of infliximab due to an unrecognized HBs-antigen carrier state.

developed

a patient with Crohn's disease

subfulminant hepatitis B

fourth infusion of infliximab

Crohn's disease

fourth

infliximab

infusion


Input: We analyzed the incidence of DVT in 232 MM patients who received a combination of chemotherapy and thalidomide on 2 protocols that differed only by the inclusion of doxorubicin in one.

incidence

232 MM patients

DVT

chemotherapy

thalidomide

MM

chemotherapy

thalidomide

chemotherapy

thalidomide


Input: Valvular heart disease in a patient taking benfluorex.

taking

a patient

Valvular heart disease

benfluorex


Input: The fifth patient exhibited paraesthesia and agitation caused by olanzapine that was misdiagnosed as psychotic agitation.

caused

The fifth patient

paraesthesia and agitation

olanzapine

olanzapine


Input: Hydrocortisone may decrease the incidence of mortality associated with cardiac arrhythmias in children receiving amphotericin B overdoses.

decrease

cardiac arrhythmias in children

children

Hydrocortisone

incidence of mortality

Hydrocortisone


Input: A review of the literature found 11 children and 2 adults in whom intranasal desmopressin was associated with hyponatremia, all of whom experienced seizures or altered mental status.

associated

11 children and 2 adults

children

adults

hyponatremia

seizures or altered mental status

intranasal desmopressin

desmopressin

intranasal


Input: Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.

associated

Hepatotoxicity

D-penicillamine

rheumatoid arthritis

D-penicillamine


Input: Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.

during

Accelerated nodulosis

methotrexate

methotrexate

juvenile rheumatoid arthritis


Input: Amiodarone is a Class III antiarrhythmic with an adverse-effect profile involving many different organ systems.

adverse-effect

an adverse-effect profile involving many different organ systems

Amiodarone


Input: Nail and skin alterations associated with the use of chemotherapy have been described in the last decade involving various combinations of two different types of nail changes.

associated

Nail and skin alterations

chemotherapy

chemotherapy


Input: This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.

associated

ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel

flucytosine

flucytosine


Input: Chromosome abnormalities after chlorambucil therapy of polycythaemia vera.

after

Chromosome abnormalities

chlorambucil therapy

chlorambucil

polycythaemia vera


Input: With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.

associated

retinopathy

macular edema and reduced visual acuity

IFN

IFN


Input: Atrial fibrillation after vardenafil therapy.

after

Atrial fibrillation

vardenafil therapy

vardenafil


Input: In phase III clinical trials, the telithromycin 800 mg once-daily dose has been shown to provide close to the maximum antimicrobial activity against S. pneumoniae, Haemophilus influenzae and Staphylococcus aureus in patients with community-acquired pneumonia.

provide

patients with community-acquired pneumonia

telithromycin 800 mg once-daily dose

S. pneumoniae

Haemophilus influenzae

Staphylococcus aureus

pneumonia

telithromycin

800 mg

once-daily


Input: We suggest that meloxicam might have intestinal toxic effects when taken in high doses, because of reduced COX-2 selectivity.

have

intestinal toxic effects

meloxicam

meloxicam

high doses


Input: Atrial fibrillation following methylprednisolone pulse therapy.

following

Atrial fibrillation

methylprednisolone pulse therapy

methylprednisolone


Input: Subglottic stenosis in Wegener's granulomatosis: development during cyclophosphamide treatment with response to carbon dioxide laser therapy.

during

Subglottic stenosis in Wegener's granulomatosis

cyclophosphamide treatment with response to carbon dioxide laser therapy

cyclophosphamide

Wegener's granulomatosis


Input: Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain.

induced

a patient with neuropathic pain

cortical negative myoclonus

Pregabalin

neuropathic pain

Pregabalin


Input: We conclude that quinine does not improve the survival of adult patients with de novo AML, even though it improves CR rate in a small subgroup of patients defined by rhodamine 123 efflux.

improves

a small subgroup of patients defined by rhodamine 123 efflux

rhodamine 123 efflux

a small subgroup

improves CR rate

quinine

de novo AML

quinine


Input: The mechanism of RTA induced by FK506 has not yet been clearly elucidated.

induced

RTA


Input: The risk of new-onset diabetic ketoacidosis in patients with diabetic risk factors who are taking perospirone hydrochloride or other atypical antipsychotics should be kept in mind.

risk

patients with diabetic risk factors

diabetic risk factors

new-onset diabetic ketoacidosis

perospirone hydrochloride or other atypical antipsychotics

perospirone hydrochloride


Input: Severe symptomatic hyponatremia during sibutramine therapy: a case report.

during

Severe symptomatic hyponatremia

sibutramine

sibutramine


Input: Zoledronic acid-induced severe hypocalcaemia in a prostate cancer patient with extensive osteoblastic bone metastases.

induced

prostate cancer patient with extensive osteoblastic bone metastases

severe hypocalcaemia

Zoledronic acid

Zoledronic acid

prostate cancer

extensive osteoblastic bone metastases


Input: MM patients treated with thalidomide and doxorubicin have a high risk of developing DVT.

have

MM patients

a high risk of developing DVT

thalidomide and doxorubicin

MM

thalidomide

doxorubicin

thalidomide

doxorubicin


Input: These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals.

induced

HIV-positive individuals

arrhythmias

lopinavir/ritonavir

lopinavir

ritonavir

HIV

lopinavir

ritonavir


Input: Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis.

taking

a patient

Atrial fibrillation

etanercept plus methotrexate for rheumatoid arthritis

etanercept

methotrexate

rheumatoid arthritis

etanercept

methotrexate


Input: We describe a 52-year-old male diagnosed with stage III multiple myeloma, who was treated with 5-monthly cycles of VAD (vincristine, adriamycin and dexamathasone).

treated

a 52-year-old male

male

5-monthly cycles of VAD (vincristine, adriamycin and dexamathasone)

stage III multiple myeloma

vincristine

adriamycin

dexamathasone

vincristine

adriamycin

dexamathasone


Input: We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved.

after

cutaneous necrosis

standard interferon alfa

pegylated interferon alfa-2b

injection

standard interferon alfa

pegylated interferon alfa-2b


Input: Our cohort included 1739 patients with acute ischemic stroke treated with intravenous tissue plasminogen activator of whom 125 (7.2%) were receiving warfarin before admission and had an international normalized ratio <1.7.

treated

1739 patients

intravenous tissue plasminogen activator

intravenous

tissue plasminogen activator


Input: Used injudiciously, naloxone can lead to withdrawal syndrome, return of severe pain, and other adverse effects.

lead

withdrawal syndrome, return of severe pain, and other adverse effects

Used injudiciously, naloxone

naloxone


Input: When vague symptoms develop during desmopressin therapy, hyponatremia must be considered as part of the differential diagnosis.

during

vague symptoms

hyponatremia

desmopressin

desmopressin


Input: Intravesical chemotherapy may be associated with a risk of secondary malignancy.

associated

secondary malignancy

Intravesical chemotherapy

Intravesical

chemotherapy


Input: In all the cases described here, it is only with the discontinuation of methylphenidate that the adverse reactions resolved and readministration of methylphenidate in two patients did not produce any adverse effect after a drug-free interval.

resolved

adverse reactions

discontinuation of methylphenidate

methylphenidate


Input: Discontinuation of methicillin therapy and appropriate antibiotic treatment of endocarditis led to clinical improvement, emphasizing the need to promptly discontinue potential nephrotoxic agents when abnormalities in renal function appear.

appear.

abnormalities in renal function

methicillin

methicillin

antibiotic

nephrotoxic agents

endocarditis


Input: CONCLUSIONS: This study confirmed that in most patients MTX-induced liver cirrhosis is not aggressive.

induced

most patients

liver cirrhosis is not aggressive

MTX

MTX


Input: We report the case of severe liver toxicity with jaundice during radiochemotherapy with temozolomide likely due to interaction with a popular Chinese herbal formula after surgery for glioblastoma.

due

severe liver toxicity with jaundice

temozolomide

a popular Chinese herbal formula

glioblastoma

temozolomide

Chinese herbal formula

temozolomide

Chinese herbal formula


Input: He was started on oral lansoprazole 60 mg twice daily and, on hospital day 2, his platelet count decreased to 102 x 10(3)/mm(3); on hospital day 3, the platelet count was 36 x 10(3)/mm(3).

on

He

He

platelet count decreased

oral lansoprazole 60 mg twice daily

oral

lansoprazole

60 mg

twice daily

day 2


Input: She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.

developed

She

She

hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure

450-mg bolus injection of morphine

morphine

bolus injection


Input: We describe six patients who developed tardive dyskinesia after treatment with sulpiride for depression or gastrointestinal symptoms.

developed

six patients

six

tardive dyskinesia

sulpiride

sulpiride

depression

gastrointestinal symptoms


Input: A 38-year-old white female with cystic fibrosis treated with venlafaxine 300 mg/day for one year was prescribed linezolid 600 mg intravenously every 12 hours for treatment of methicillin-resistant Staphylococcus aureus (MRSA) pulmonary infection.

treated

A 38-year-old white female

white

female

venlafaxine 300 mg/day for one year

cystic fibrosis

300 mg/day

venlafaxine

one year


Input: Hepatotoxicity of hycanthone in patients with metastatic breast cancer.

of

patients with metastatic breast cancer

Hepatotoxicity

hycanthone

metastatic breast cancer

hycanthone


Input: The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.

induced

multifocal leukoencephalopathy

capecitabine

capecitabine


Input: Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer.

under

Chlormadinone acetate

androgen blockade

advanced prostate cancer

Chlormadinone acetate

androgen blockade

androgen blockade

Chlormadinone acetate


Input: Restless legs syndrome and periodic limb movements during sleep probably associated with olanzapine.

associated

Restless legs syndrome

periodic limb movements during sleep

olanzapine

olanzapine


Input: Evaluation of the literature provides substantial evidence for the use of hydrocortisone in prevention of cardiac arrhythmias.

prevention

hydrocortisone

hydrocortisone

cardiac arrhythmias


Input: We report a case of RTA secondary to FK506 administration in liver transplantation.

secondary

a case of RTA

RTA

FK506 administration in liver transplantation


Input: Myoclonus associated with continuous dobutamine infusion in a patient with end-stage renal disease.

associated

a patient with end-stage renal disease

Myoclonus

continuous dobutamine infusion

dobutamine

infusion

end-stage renal disease


Input: Amphotericin B nephrotoxicity in humans decreased by salt repletion.

decreased

humans

Amphotericin B nephrotoxicity in humans decreased

salt repletion

salt


Input: Only a few reports of overt jaundice are associated with streptokinase.

associated

overt jaundice

streptokinase

streptokinase


Input: Possible heart failure exacerbation associated with rosiglitazone: case report and literature review.

associated

heart failure exacerbation

rosiglitazone

rosiglitazone


Input: We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.

associated

the first case

polymorphic ventricular tachycardia with normal QT interval

arrhythmias

oral use of levofloxacin

oral

levofloxacin