Input: Reversible leukopenia was documented in an 81-year-old woman treated with adjunctive ibopamine 100 mg t.i.d. for chronic congestive heart failure.

documented

an 81-year-old woman

woman

Reversible leukopenia

adjunctive ibopamine 100 mg t.i.d.

chronic congestive heart failure

ibopamine

100 mg


Input: We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.

side effects

anti-natriuresis and increased vascular permeability

insulin

insulin


Input: Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer.

in

patients

Acute myelogenous leukemia

receiving chlorambucil as long-term adjuvant chemotherapy

chlorambucil

stage II breast cancer.

chemotherapy


Input: We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.

exposed to

generalized cutaneous sclerosis associated with muscle and oesophageal involvement

herbicides containing bromocil, diuron and aminotriazole

bromocil

diuron

aminotriazole

diuron

bromocil

aminotriazole


Input: Only 3 cases of imatinib-induced tumor lysis syndrome have been reported.

induced

tumor lysis syndrome

imatinib

imatinib


Input: A 61-year-old patient who had been treated with lisinopril in the past without any problems was commenced on ramipril for left ventricular dysfunction.

commenced

A 61-year-old patient who had been treated with lisinopril in the past without any problems

ramipril

ramipril

left ventricular dysfunction


Input: However, repeated intracameral tPA injections may cause unwanted complications such as vitreous hemorrhage.

cause

unwanted complications such as vitreous hemorrhage

repeated intracameral tPA injections

tPA

intracameral

injections


Input: In this article, we present the case of a vitiligo patient who was admitted to our facility with an intense burn after the topical use of 8-methoxypsoralen solution as a suntanning agent.

after

a vitiligo patient

vitiligo

intense burn

topical use of 8-methoxypsoralen solution as a suntanning agent

topical


Input: The frequency and relationship of granulocytopenia caused by sustained-release procainamide in patients with tachyarrhythmias are briefly discussed, and prior reported cases are reviewed.

caused

patients with tachyarrhythmias

granulocytopenia

procainamide

procainamide

tachyarrhythmias


Input: Cicatricial entropion associated with chronic dipivefrin application.

associated

Cicatricial entropion

chronic dipivefrin application

dipivefrin


Input: Nine delirious patients suffering from lithium intoxication were examined with the Mini-Mental State Exam (MMS) to describe the clinical course of the disorder.

suffering from

Nine delirious patients

Nine

delirious

lithium intoxication

lithium

lithium


Input: Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature.

in

a chronic lymphocytic leukemia patient

Cryptococcus neoformans fatal sepsis

alemtuzumab

chronic lymphocytic leukemia

alemtuzumab


Input: Cholestyramine induced hyperchloremic metabolic acidosis.

induced

hyperchloremic metabolic acidosis.

Cholestyramine

Cholestyramine


Input: Methadone is recommended as being free of some of the neuropsychological side effects noticed with morphine, which are attributed to active metabolites.

noticed

neuropsychological side effects

morphine

morphine


Input: This is the first reported case of BOOP associated with single-agent rituximab, and along with two other patients we describe, as well as two prior reports of BOOP in NHL patients receiving rituximab-based combinations, strengthens the possibility of a causal relationship.

associated

BOOP

single-agent rituximab

rituximab


Input: The treatment for acidosis and hyperkalaemia should be started as soon as RTA is diagnosed, and the dosage of FK506 should also be reduced if possible.

of

acidosis and hyperkalaemia

RTA


Input: A 62-year-old woman treated with pranlukast for 2 months developed interstitial pneumonitis with a high fever.

developed

A 62-year-old woman

woman

interstitial pneumonitis with a high fever

treated with pranlukast for 2 months

pranlukast

2 months


Input: Neurotoxicity of valacyclovir in peritoneal dialysis: a pharmacokinetic study.

Neurotoxicity

Neurotoxicity

valacyclovir in peritoneal dialysis

valacyclovir


Input: He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.

taking

He

He

headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs

maculopapular rash

trimethoprim-sulfamethoxazole for approximately eight days

trimethoprim

sulfamethoxazole

eight days

trimethoprim

sulfamethoxazole


Input: We present an AIDS patient with severe and prolonged lactic acidosis on stavudine and lamivudine.

present

an AIDS patient

severe and prolonged lactic acidosis

stavudine and lamivudine

AIDS

stavudine

lamivudine

stavudine

lamivudine


Input: Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.

during

Sudden cardiac death due to hypersensitivity myocarditis

clozapine

clozapine


Input: It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium.

contributes

hypertension

lead exposure

lead

exposure


Input: We report an allogeneic bone marrow transplant recipient who developed CMV infection refractory to sequential therapy with ganciclovir, foscarnet, and cidofovir.

refractory

allogeneic bone marrow transplant recipient

allogeneic bone marrow transplant

sequential therapy with ganciclovir, foscarnet, and cidofovir

CMV infection

ganciclovir

foscarnet

cidofovir

ganciclovir

foscarnet

cidofovir


Input: Acute interstitial pneumonia induced by ONO-1078 (pranlukast), a leukotriene receptor antagonist.

induced

Acute interstitial pneumonia

ONO-1078 (pranlukast)


Input: CONCLUSION: Significant ocular complications such as an irreversible decrease of visual acuity may develop in patients treated with pegylated interferon.

treated

patients

irreversible decrease of visual acuity

pegylated interferon

pegylated interferon


Input: CONCLUSIONS: This case report showed that the clinical appearance of Hashimoto's disease after IFN-alpha therapy for chronic C hepatitis in our patient was associated with a specific genetic predisposition (DR5) for this pathology.

after

our patient

a specific genetic predisposition (DR5) for this pathology

clinical appearance of Hashimoto's disease

IFN-alpha

chronic C hepatitis

IFN-alpha


Input: We present here a female patient who developed acute bilateral parotitis within minutes of i.v. enalaprilat injection and recovered within 24 hours of stopping the drug and with symptomatic treatment.

developed

a female patient

female

acute bilateral parotitis

i.v. enalaprilat injection

enalaprilat

injection

within minutes


Input: We describe 2 patients with prior amputation who experienced phantom limb pain (PLP) after receiving paclitaxel therapy.

after

2 patients with prior amputation

prior amputation

phantom limb pain (PLP)

paclitaxel therapy

paclitaxel


Input: There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule.

increases

increases urate excretion

reducing reabsorption of urate in the renal proximal tubule.

angiotensin II receptor antagonist, losartan

losartan


Input: Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.

favored

hemorrhage

metformin

metformin


Input: We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.

associated

one patient

peripheral neuropathy

infliximab therapy

necrotizing vasculitis

infliximab


Input: Upper tract urothelial malignancy after cyclophosphamide therapy: a case report and literature review.

after

Upper tract urothelial malignancy

cyclophosphamide therapy

cyclophosphamide


Input: BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.

induce

liver damage, which in some psoriatics will lead to fibrosis or cirrhosis

Methotrexate (MTX)

Methotrexate

psoriatics


Input: The infection proceeded even after treatment with fluconazole.

after

infection proceeded

fluconazole

fluconazole


Input: We report the case of intoxication of a 41-year-old female patient suffering from major depression with mirtazapine complicated by severe hypothermia.

with

a 41-year-old female patient

female

intoxication

hypothermia

mirtazapine

major depression

mirtazapine


Input: The bilateral ptosis markedly improved after 7 days of pyridoxine and pyridostigmine treatment and completely resolved after two weeks.

improved

pyridoxine and pyridostigmine treatment

7 days

pyridoxine

pyridostigmine

pyridoxine

pyridostigmine


Input: PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.

developed

a patient

aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension

trimethoprim-sulfamethoxazole

trimethoprim-sulfamethoxazole


Input: Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.

treated

a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis

Seizures and extrapyramidal symptoms

interferon beta-1a and clomipramine

clomipramine

interferon beta-1a

Tourette's syndrome

Asperger's syndrome

multiple sclerosis

interferon beta-1a

clomipramine


Input: Psychotic disorder associated with isoniazid.

associated

Psychotic disorder

isoniazid

isoniazid


Input: The azathioprine dose was low (1 mg/kg) and pancytopenia occurred after 56 days therapy.

occurred

pancytopenia

56 days therapy

The azathioprine dose was low (1 mg/kg)

56 days

azathioprine

1 mg/kg


Input: Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine.

side effect

hair loss

paroxetine.

paroxetine


Input: The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases.

have

patients

anaphylactic reactions

MTX

MTX


Input: Clomiphene is a first line treatment for anovulation, a common cause of infertility.

treatment

Clomiphene

Clomiphene

anovulation


Input: A new case of Creutzfeldt-Jakob disease associated with human growth hormone therapy in New Zealand.

associated

A new case

Creutzfeldt-Jakob disease

human growth hormone

human growth hormone


Input: This case study is the second report of localized purpura after prolonged lamotrigine treatment suggesting this may be an atypical lamotrigine-induced drug reaction.

induced

localized purpura

drug reaction

lamotrigine

lamotrigine

prolonged


Input: Extrapyramidal symptoms are well-documented complications of therapy with haloperidol, even when small doses are used.

complications

Extrapyramidal symptoms

haloperidol

small doses

haloperidol

small doses


Input: Although cetirizine has less potential for causing arrhythmias than other histamine 1 blockers, such an interaction should be considered, especially in patients with renal insufficiency who are receiving pilsicainide.

causing

patients with renal insufficiency

renal insufficiency

arrhythmias

cetirizine

cetirizine


Input: Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non-Hodgkin's lymphoma.

after

Bronchiolitis obliterans with organizing pneumonia

rituximab therapy

rituximab

non-Hodgkin's lymphoma


Input: The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.

to

hypersensitivity reaction

pranlukast

pranlukast

pranlukast


Input: Successful desensitization to high-dose methotrexate after systemic anaphylaxis.

after

systemic anaphylaxis.

high-dose methotrexate

methotrexate

high-dose


Input: The patient's clinical presentation, histologic features on liver biopsy and favorable course after stopping the drug suggest that barbiturates can be added to the list of agents which can cause submassive hepatic necrosis.

cause

submassive hepatic necrosis

barbiturates

barbiturates


Input: Although there have been numerous reports of effusions, none have provided complete pleural fluid analysis; therefore, we report 2 patients with dasatinib-induced pleural effusion with complete pleural fluid analysis.

induced

2 patients

pleural effusion

dasatinib

dasatinib


Input: Morphea after bromocriptine therapy.

after

Morphea

bromocriptine therapy

bromocriptine


Input: PURPOSE: To describe the clinical and electrophysiological findings in a young boy with decreased vision possibly due to retinal damage by rifabutin.

due

a young boy

young

boy

decreased vision

retinal damage

rifabutin

rifabutin


Input: We reported a case of disulfiram-induced hepatitis with unique clinical features and compared our case with others in the literature.

induced

a case

hepatitis

disulfiram

disulfiram


Input: We report a patient receiving chronic lithium therapy who presented with a transient CDI occurring in the setting of underlying chronic NDI.

presented

patient

underlying chronic NDI

transient CDI

chronic lithium therapy

lithium

chronic


Input: Here we report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all-trans retinoic acid therapy.

developed

a patient with newly diagnosed acute promyelocytic leukemia

acute focal myositis, synovitis, and possible vasculitis

all-trans retinoic acid

acute promyelocytic leukemia

all-trans retinoic acid


Input: We report a case of methotrexate toxicity potentially induced by a drug interaction between methotrexate and omeprazole in a 25-year-old man with osteosarcoma.

induced

a 25-year-old man with osteosarcoma

man

osteosarcoma

methotrexate toxicity

methotrexate and omeprazole

methotrexate

omeprazole

methotrexate

omeprazole


Input: Increasing the olanzapine dosage severely aggravated the symptoms of RLS.

aggravated

symptoms of RLS

Increasing the olanzapine dosage

olanzapine


Input: We report a case of 48-year-old woman with seizure disorder on divalproex sodium (Depakote) who presented with dyspnea.

presented

a case of 48-year-old woman with seizure disorder

woman

dyspnea

divalproex sodium (Depakote)

seizure disorder

divalproex sodium


Input: To report a probable interaction between warfarin and marijuana smoking, resulting in increased international normalized ratio (INR) values and bleeding complications.

resulting

increased international normalized ratio (INR) values and bleeding complications

interaction between warfarin and marijuana smoking

warfarin

marijuana

smoking

warfarin

marijuana


Input: Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection.

related

two patients with HIV infection

two

Transient cardiac arrhythmias

lopinavir/ritonavir

HIV infection

lopinavir

ritonavir

lopinavir

ritonavir


Input: Interestingly, the use of carboplatin (CBDCA) and VDS in the subsequent treatment course was well tolerated indicating that the SIADH was most likely to have been induced by administration of CDDP.

induced

SIADH

CDDP

CDDP


Input: Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts.

manifest

thrombocytopenia

heparin-dependent antibodies (HDAs)

heparin


Input: A 69-year-old white female whose anticoagulation treatment had been stable for 18 months with warfarin 2.5 mg daily (17.5 mg/wk) presented to an anticoagulation clinic with a critically elevated INR of greater than 12.3 after a dose increase in extended-release niacin (Niaspan) from 500 mg to 1000 mg daily the previous week.

after

69-year-old white female

white

female

elevated INR of greater than 12.3

anticoagulation treatment had been stable for 18 months with warfarin 2.5 mg daily (17.5 mg/wk)

dose increase in extended-release niacin (Niaspan) from 500 mg to 1000 mg daily the previous week

extended-release niacin

warfarin

1000 mg

2.5 mg

daily

daily

extended-release niacin

warfarin


Input: The most serious dental side effect of bisphosphonate treatment (particularly when it is administered intravenously) is, paradoxically, osteonecrosis of the mandible or the maxilla represented by exposed nonhealing bone.

side effect

osteonecrosis of the mandible or the maxilla represented by exposed nonhealing bone

bisphosphonate treatment (particularly when it is administered intravenously)

bisphosphonate

intravenously


Input: Pericardial hemorrhage due to acetylsalicylic acid in a patient with essential thrombocythemia.

due

Pericardial hemorrhage

acetylsalicylic acid

acetylsalicylic acid


Input: These cases and a review of the literature suggested that hepatotoxicity, though rare, should be added to the list of adverse reactions to D-penicillamine.

adverse

These cases

hepatotoxicity

D-penicillamine

D-penicillamine


Input: After four months, while receiving RH, he developed painful bilateral gynaecomastia.

developed

painful bilateral gynaecomastia

receiving RH

RH

After four months


Input: The plasma concentrations of both drugs were significantly increased during the coadministration, and the cetirizine concentration decreased on cessation of pilsicainide despite the fact that treatment with cetirizine was continued, which suggested that the fainting was induced by the pharmacokinetic drug interaction.

induced

fainting

pilsicainide

cetirizine

pilsicainide

cetirizine

pilsicainide

cetirizine


Input: OBJECTIVE: To report a case of multiple episodes of seizure activity in an AIDS patent following amphotericin B infusion.

following

an AIDS patent

multiple episodes of seizure activity

amphotericin B infusion

AIDS

amphotericin B

infusion


Input: The vomiting occurred on switching to different pancreatic enzymes preparations, ie, Creon 10, Viokase, and Pancrease MT 16.

switching

vomiting

different pancreatic enzymes preparations, ie, Creon 10, Viokase, and Pancrease MT 16

Creon 10

Viokase

Pancrease MT 16


Input: Although tardive dyskinesia is a known adverse reaction of sustained treatment with traditional neuroleptic agents, it was only rarely reported in association with sulpiride, a selective D2-receptor antagonist.

association

tardive dyskinesia

sulpiride

sulpiride


Input: This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.

induced

a patient

dysphagia

haloperidol

haloperidol

obsessive nocturnal thoughts and auditory disturbances


Input: In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.

during

disease progression from chronic phase to blast crisis

imatinib therapy

imatinib


Input: We report a typical case of transient serotonin syndrome secondary to tramadol-Citalopram combination.

secondary

a typical case

transient serotonin syndrome

tramadol-Citalopram combination

tramadol

Citalopram

tramadol

Citalopram


Input: Although use of the Naranjo adverse reaction probability scale indicated a probable relationship (score of 6) between the patient's development of methotrexate toxicity and omeprazole use, we believe this was a drug-drug interaction case consistent with previous reports in the literature.

relationship

the patient

methotrexate toxicity

methotrexate

and omeprazole use

methotrexate

omeprazole

methotrexate

omeprazole


Input: Systemic cyclosporin (10 mg/kg/day) resulted in resolution of the corneal ulceration within two weeks of beginning treatment, and the patient has remained in remission after 15 months of therapy.

resulted

patient

resolution of the corneal ulceration

Systemic cyclosporin (10 mg/kg/day)

10 mg/kg/day

Systemic cyclosporin


Input: We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.

developed

a 59-year-old patient with chronic myeloid leukemia

interstitial lung fibrosis

short term and sequential treatment with melphalan and busulfan

chronic myeloid leukemia

short term

melphalan

busulfan

melphalan

busulfan


Input: Does the use of insulin in a patient with liver dysfunction increase water retention in the body, i.e. cause insulin oedema?

use

a patient with liver dysfunction

increase water retention in the body, i.e. cause insulin oedema?

insulin

insulin

liver dysfunction


Input: Sustained hypothyroidism induced by recombinant alpha interferon in patients with chronic hepatitis C.

induced

patients with chronic hepatitis C.

Sustained hypothyroidism

recombinant alpha interferon

chronic hepatitis C.

recombinant alpha interferon


Input: Withdrawal of Depakote resulted in resolution of the effusion.

resulted

resolution of the effusion

Withdrawal of Depakote

Depakote


Input: Adenosine-induced ventricular fibrillation.

induced

ventricular fibrillation

Adenosine

Adenosine


Input: Evaluation of initial and steady-state gatifloxacin pharmacokinetics and dose in pulmonary tuberculosis patients by using monte carlo simulations.

in

pulmonary tuberculosis patients

gatifloxacin

pulmonary tuberculosis

gatifloxacin


Input: We report two patients with acne vulgaris with a fourth type of minocycline-induced cutaneous pigmentation.

induced

two patients with acne vulgaris

two

fourth type of

cutaneous pigmentation

minocycline

minocycline

acne vulgaris


Input: Budesonide is a synthetic glucocorticosteroid that is commonly used in topical treatment of asthma and rhinitis.

used in

Budesonide

asthma and rhinitis.

Budesonide


Input: Cyclosporin therapy in Mooren's ulcer.

therapy

Cyclosporin

Mooren's ulcer

Cyclosporin


Input: She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.

developed

She

She

neurotoxicity

adjustment dosage of valacyclovir

adjustment dosage

valacyclovir

cutaneous zoster infection


Input: Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.

after

Nine eyes from 6 patients, 74 years to 90 years of age

74 years to 90 years

cicatricial entropion

at least 2 years of twice-a-day application of dipivefrin

2 years

twice-a-day

dipivefrin


Input: We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.

developed

two patients with chronic myelocytic leukemia

local cutaneous reactions at sites of injection

administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses

chronic myelocytic leukemia

pegylated interferon alfa-2b

different doses

weekly

subcutaneous injections


Input: Artemether-lumefantrine (AL) is first-line treatment for uncomplicated malaria in many African countries.

first-line treatment

Artemether-lumefantrine (AL)

uncomplicated malaria

Artemether-lumefantrine


Input: Functional regulation of certain neuroreceptors during risperidone treatment may lead to altered behavioural responses upon switching to methylphenidate.

lead

altered behavioural responses

risperidone

switching to methylphenidate

risperidone

methylphenidate


Input: Transient leucopenia and thrombocytopenia associated with sodium nitroprusside infusion.

associated

Transient leucopenia and thrombocytopenia

sodium nitroprusside infusion

infusion

sodium nitroprusside


Input: This unusual pattern of low-grade endometrial carcinoma adds to the spectrum of uterine neoplasia associated with tamoxifen therapy.

associated

unusual pattern of low-grade endometrial carcinoma adds to the spectrum of uterine neoplasia

tamoxifen

tamoxifen


Input: Inappropriate antidiuretic hormone secretion after high dose vinblastine.

after

Inappropriate antidiuretic hormone secretion

high dose vinblastine

vinblastine

high dose


Input: Osteomyelitis occurring during infliximab treatment of severe psoriasis.

treatment

Osteomyelitis

infliximab

infliximab

severe psoriasis


Input: We describe a patient with transitional cell carcinoma of the renal pelvis who developed respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities while on chemotherapy with piritrexim, a methotrexate analog.

developed

a patient with transitional cell carcinoma of the renal pelvis

respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities

chemotherapy with piritrexim, a methotrexate analog

transitional cell carcinoma of the renal pelvis

piritrexim

chemotherapy


Input: Amiodarone induced torsades de pointe.

induced

torsades de pointe

Amiodarone

Amiodarone


Input: A patient with Wegener's granulomatosis rapidly developed a circumferential subglottic stenosis while on a cyclophosphamide regimen that had caused resolution of systemic symptoms and pulmonary infiltrates.

developed

A patient with Wegener's granulomatosis

circumferential subglottic stenosis

resolution of systemic symptoms and pulmonary infiltrates

cyclophosphamide regimen

cyclophosphamide

Wegener's granulomatosis


Input: A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder.

between

A case

coagulation disorder

fatal interaction

minoxidil

minoxidil


Input: Methadone-induced myoclonus in advanced cancer.

induced

myoclonus

Methadone

advanced cancer

Methadone


Input: Life-threatening anaphylactoid reaction to amifostine used with concurrent chemoradiotherapy for nasopharyngeal cancer in a patient with dermatomyositis: a case report with literature review.

to

a patient with dermatomyositis

dermatomyositis

Life-threatening anaphylactoid reaction

amifostine used with concurrent chemoradiotherapy

nasopharyngeal cancer

amifostine

chemoradiotherapy

amifostine

chemoradiotherapy


Input: We conclude that while thrombocytopenia and schistocytosis can be seen in quinine-associated TTP/HUS, the pathophysiology seems to be distinct from that seen in most cases of idiopathic TTP (i.e., severely decreased ADAMTS13 with an inhibitor).

associated

thrombocytopenia and schistocytosis

TTP/HUS

quinine

quinine


Input: CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.

considered

Spontaneous hemothorax

acute respiratory distress

LMWH

LMWH


Input: CONCLUSION: These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers.

interfere

These cases

interfere with the healing of corneal ulcers

moxifloxacin

moxifloxacin


Input: Reinstitution of penicillamine treatment caused a recurrence thus proving a causal relationship between penicillamine and the described nail-changes.

causal relationship

nail-changes

penicillamine

penicillamine

penicillamine


Input: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.

developed

A 34-year-old lady

lady

a constellation of dermatitis, fever, lymphadenopathy and hepatitis

a course of oral sulphasalazine

oral

sulphasalazine

sero-negative rheumatoid arthritis

17th day


Input: He had been commenced on a course of fusidic acid at discharge in addition to his ongoing statin prescription and presented 4 weeks later with symptoms consistent with rhabdomyolysis.

presented

symptoms consistent with rhabdomyolysis

a course of fusidic acid at discharge in addition to his ongoing statin prescription

statin

fusidic acid

4 weeks later

fusidic acid

statin


Input:
1.
Artelinic acid (AL), a water-soluble artemisinin analogue for treatment of multidrug resistant malaria, is metabolized to the active metabolite dihydroqinghaosu (DQHS) solely by  CYP3A4/5.

treatment

Artelinic acid (AL), a water-soluble artemisinin analogue

multidrug resistant malaria

Artelinic acid


Input: Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.

associated

a patient with cystic fibrosis

recurrent eosinophilia and severe persistent bronchospasm

Inhaled tobramycin

cystic fibrosis

tobramycin

Inhaled


Input: The occurrence of BMTN in two children treated with RA in our unit is unlikely to be coincidental.

treated

two children

two

children

BMTN

RA

RA


Input: Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.

after

Comeoscleral perforation

pterygium excision and intraoperative mitomycin C.

mitomycin C.


Input: Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.

induced

five cases

five

multifocal leukoencephalopathy

Capecitabine

Capecitabine


Input: Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug.

induced

visual field defects

Vigabatrin

Vigabatrin


Input: Serotonin syndrome in elderly patients treated for psychotic depression with atypical antipsychotics and antidepressants: two case reports.

with

elderly patients

elderly

Serotonin syndrome

atypical antipsychotics

antidepressants

atypical antipsychotics

antidepressants

psychotic depression

atypical antipsychotics

antidepressants


Input: We report two new cases of sarcoidosis in two patients with hepatitis C virus infection treated with interferon alfa and ribavirin.

in

two patients with hepatitis C virus infection

two

sarcoidosis

interferon alfa and ribavirin

hepatitis C virus infection

interferon alfa

ribavirin

interferon alfa

ribavirin


Input: A 57-year-old man developed morphea while taking bromocriptine.

taking

A 57-year-old man

man

morphea

bromocriptine

bromocriptine


Input: Potential mechanisms regarding the pathophysiology of lithium-associated CDI are discussed.

associated

CDI

lithium

lithium


Input: Acute coronary syndromes complicating the first infusion of rituximab.

complicating

Acute coronary syndromes

the first infusion of rituximab

infusion

rituximab


Input: Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin.

with

Spontaneous hemothorax following anticoagulation

low-molecular-weight heparin

low-molecular-weight heparin


Input: There were no incremental increases in myelosuppression, peripheral neuropathy, or renal, hepatic, or cardiac toxicity and no deaths related to tirapazamine.

related

no incremental increases in myelosuppression, peripheral neuropathy, or renal, hepatic, or cardiac toxicity and no deaths

tirapazamine

tirapazamine


Input: A phase III trial, Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors (CATAPULT I), was designed to determine the efficacy and safety of tirapazamine plus cisplatin for the treatment of non-small-cell lung cancer (NSCLC).

treatment

tirapazamine plus cisplatin

tirapazamine

cisplatin

non-small-cell lung cancer (NSCLC)

tirapazamine

cisplatin


Input: Combination antimicrobial regimens (e.g., linezolid with rifampin) aimed at improving bacterial eradication and preventing resistance are often used; however, most data supporting this treatment strategy are not from randomized controlled trials.

aimed

improving bacterial eradication and preventing resistance

Combination antimicrobial regimens (e.g., linezolid with rifampin)

linezolid

rifampin

linezolid

rifampin


Input: Clinicians treating elderly patients with a combination of serotonergic antidepressants and atypical antipsychotics for psychotic depression should be aware of the potential for serotonin syndrome.

be aware

elderly patients

elderly

serotonin syndrome

a combination of serotonergic antidepressants and atypical antipsychotics for psychotic depression

psychotic depression

serotonergic antidepressants

atypical antipsychotics

serotonergic antidepressants

atypical antipsychotics


Input: Enalaprilat induced acute parotitis.

induced

acute parotitis

Enalaprilat

Enalaprilat


Input: We believe the most likely cause was hepatic inhibition of the CYP3A4 hepatic isoenzyme by fusidic acid resulting in an acute severe rise in plasma simvastatin level and extensive myocellular damage.

resulting

an acute severe rise in plasma simvastatin level and extensive myocellular damage

fusidic acid

fusidic acid


Input: The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia.

related

a patient with essential thrombocythemia

pericardial hemorrhage

low-dose acetylsalicylic acid

acetylsalicylic acid

low-dose

essential thrombocythemia


Input: This complex pattern of nail and skin changes is accounted by synergy or an additive effect of chemotherapy agents on cellular proliferation of nail compartments.

synergy or an additive effect

complex pattern of nail and skin changes

chemotherapy agents

chemotherapy agents


Input: Akathisia is a relatively rare side effect with the newer atypical antipsychotic agents, particularly clozapine, and is easily misdiagnosed in children.

with

children

Akathisia

clozapine

clozapine


Input: In this case, discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment plan helped resolve a patient's ulcers.

resolve

a patient's

discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment

ulcers

piroxicam


Input: Eosinophilia has been encountered from 0.2 to 61.7% in clozapine-treated patients, mostly with a transient course and spontaneous remission.

encountered

patients

Eosinophilia

clozapine

clozapine


Input: We presented a patient with status asthmaticus treated with a combination of theophylline and prednisone who developed a perforated gastric ulcer.

developed

a patient with status asthmaticus

perforated gastric ulcer

theophylline and prednisone

theophylline

prednisone

status asthmaticus

theophylline

prednisone


Input: We speculate on a causal relationship between the assumption of the additives and the fatal hepatitis and envisage a synergy between the additives and montelukast, which per se has well been studied as a hepatotoxic drug.

relationship

the fatal hepatitis

montelukast

montelukast


Input: Fatal liver failure following food supplements during chronic treatment with montelukast.

following

Fatal liver failure

food supplements during chronic treatment with montelukast

food supplements

montelukast

food supplements

montelukast


Input: The nodules regressed after withdrawal of methotrexate therapy in one patient and were arrested with the addition of hydroxychloroquine in the other.

after

one patient

one

regressed

withdrawal of methotrexate therapy

nodules

methotrexate


Input: Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor.

Treatment

granulocyte colony stimulating factor

carbimazole-induced agranulocytosis and sepsis

granulocyte colony stimulating factor


Input: A study following large patient groups on theophylline and a combination of theophylline and steroids might clarify the risk of ulcer formation in patients being treated with these medications for asthma.

risk

large patient groups

ulcer

theophylline and a combination of theophylline and steroids

theophylline

theophylline

steroids

asthma

theophylline

steroids


Input: The combination of cyclobenzaprine and fluoxetine resulted in significant QT prolongation in our patient that progressed to torsade de pointes after preoperative droperidol administration.

resulted

our patient

significant QT prolongation

progressed to torsade de pointes

The combination of cyclobenzaprine and fluoxetine

preoperative droperidol administration

cyclobenzaprine

fluoxetine

droperidol

preoperative

cyclobenzaprine

fluoxetine

droperidol


Input: INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH).

intoxication

a patient

phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH)

phenytoin

phenytoin


Input: This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.

caused

severe illness

minocycline

minocycline


Input: RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.

developed

Three patients

Three

symptoms of inflammatory bowel disease (IBD)

rofecoxib exposure

rofecoxib

exposure


Input: Radiation recall refers to inflammatory reactions triggered by cytotoxic agents and develops in previously irradiated areas.

triggered

Radiation recall

inflammatory reactions

cytotoxic agents

cytotoxic


Input: Herein, we describe 2 patients who developed unusual CD8+ cutaneous lymphoproliferative disorders after treatment with efalizumab and infliximab.

developed

2 patients

CD8+ cutaneous lymphoproliferative

efalizumab and infliximab

efalizumab

infliximab

efalizumab

infliximab


Input: Intrathecal methotrexate-induced acute cerebellar syndrome.

induced

acute cerebellar syndrome

methotrexate

methotrexate


Input: Barbiturate-induced submassive hepatic necrosis.

induced

submassive hepatic necrosis

Barbiturate

Barbiturate


Input: The possible effects of tamoxifen upon the uterus are discussed in this article, in view of reports of tamoxifen associated with endometrial carcinoma and endometriosis.

associated

endometrial carcinoma and endometriosis

tamoxifen

tamoxifen


Input: Three patients who had experienced neuroleptic-induced akathisia in the past reported that the symptoms of fluoxetine-induced akathisia were identical, although somewhat milder.

induced

Three patients

neuroleptic-induced akathisia

Three

akathisia

fluoxetine

fluoxetine


Input: Intranasal desmopressin-induced hyponatremia.

induced

hyponatremia

Intranasal desmopressin

Intranasal

desmopressin


Input: Sunburn may sometimes be a major injury in psoralen users because high doses or inappropriate use of the drug may render the skin extremely sensitive.

render

users

Sunburn

skin extremely sensitive

psoralen users because high doses or inappropriate use

psoralen

high doses


Input: Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature.

treatable

high-dose folinic acid

Methotrexate-induced leukoencephalopathy

high-dose

folinic acid


Input: We reviewed the records of 3 patients with lymphoproliferative disorders who experienced acute coronary syndromes associated with their initial infusion of rituximab.

associated

3 patients with lymphoproliferative disorders

acute coronary syndromes

their initial infusion of rituximab

lymphoproliferative disorders

rituximab

infusion


Input: Previous successful treatment with one ACE inhibitor does not rule out the vasculitis caused by the drug from the same group.

caused

vasculitis

ACE inhibitor

ACE inhibitor


Input: We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).

following

a patient with pulmonary adenocarcinoma

the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)

systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS)

pulmonary adenocarcinoma

cisplatin

vindesine

vindesine

cisplatin


Input: Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.

after

headache, mild fever, nausea, vomiting, rash, and eosinophilia

after 3 weeks of disulfiram

disulfiram

after 3 weeks


Input: Decreased serum linezolid levels in a critically ill patient receiving concomitant linezolid and rifampin.

receiving

a critically ill patient

critically ill

Decreased serum linezolid levels

concomitant linezolid and rifampin

linezolid

rifampin

linezolid

rifampin


Input: OBJECTIVE: To report the first five cases of amphotericin B overdose with secondary cardiac complications in a pediatric population.

secondary

first five cases of

a pediatric population

pediatric

five

cardiac complications

amphotericin B overdose

amphotericin B

overdose


Input: CONCLUSIONS: Amphotericin B seems to be the probable cause of the seizures.

cause

seizures

Amphotericin B

Amphotericin B


Input: We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously.

developed

a patient

acute cerebellar syndrome

prophylactic intrathecal methotrexate administration

methotrexate

intrathecal


Input: Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.

induced

polymorphic ventricular tachycardia with normal QT interval

Levofloxacin

Levofloxacin


Input: Most physicians are aware of serotonin syndrome secondary to antidepressants but do not think about other classes of medications such as analgesics.

secondary

serotonin syndrome

antidepressants

antidepressants

analgesics


Input: Renal toxicity signs, induced by amphotericin B, progression of infection after fluconazole, and likely in vivo resistance to this triazole made this case difficult to treat.

induced

Renal toxicity signs

amphotericin B

amphotericin B


Input: We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation.

following

two patients

two

aspergillus arthritis of the knee joint

fludarabine-based non-myeloablative stem cell transplantation

fludarabine


Input: A case of fluoxetine induced seizures, in a person with Down syndrome, is described.

induced

a person with Down syndrome

Down syndrome

seizures

fluoxetine

fluoxetine


Input: We report a case of acute generalized exanthematous pustulosis (AGEP) induced by salazosulfapyridine in a patient with ulcerative colitis.

induced by

a patient with ulcerative colitis

acute generalized exanthematous pustulosis (AGEP)

salazosulfapyridine

ulcerative colitis

salazosulfapyridine


Input: Diclofenac-associated hepatitis.

associated

hepatitis

Diclofenac

Diclofenac


Input: Angioimmunoblastic lymphadenopathy with dysproteinemia following doxycycline administration.

following

Angioimmunoblastic lymphadenopathy with dysproteinemia

doxycycline administration

doxycycline


Input: Doxycycline-induced hypoglycemia in a nondiabetic young man.

induced

a nondiabetic young man

man

young

hypoglycemia

Doxycycline

Doxycycline


Input: Case 2 demonstrated after 40 months on chlorambucil the presence of a balanced translocation, t (1;5) (p36;q31) in 90% of the cells.

presence of

Case 2

a balanced translocation, t (1;5) (p36;q31) in 90% of the cells

40 months on chlorambucil

chlorambucil

40 months


Input: Within 6 months of pranlukast withdrawal, anemia resolved and urinary sediment and renal function normalized.

withdrawal,

anemia resolved and urinary sediment and renal function normalized

pranlukast

pranlukast

6 months

anemia

urinary sediment

renal function


Input: Sirolimus-associated hepatotoxicity in the kidney graft recipient.

associated

kidney graft recipient.

hepatotoxicity

Sirolimus

Sirolimus

kidney graft recipient


Input: Although vasculitis has been reported in the course of hairy cell leukaemia, it has only rarely been reported as the consequence of cladribine treatment.

consequence

vasculitis

cladribine

hairy cell leukaemia

cladribine


Input: Despite aggressive medical management, including intravenous hydration and broad-spectrum antibiotics, the patient continued to become more confused, agitated, and despondent over the subsequent 24 hours.

continued

patient

become more confused, agitated, and despondent over the subsequent 24 hours

intravenous hydration and broad-spectrum antibiotics

hydration

broad-spectrum antibiotics

intravenous

hydration

broad-spectrum antibiotics


Input: Cyclosporine is a potent inhibitor of simvastatin metabolism, and may therefore facilitate simvastatin-induced rhabdomyolysis.

facilitate

Cyclosporine is a potent inhibitor of simvastatin metabolism

Cyclosporine


Input: The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria.

receiving

African children

African

children

artemether-lumefantrine crushed or dispersible tablets (Coartem)

acute uncomplicated Plasmodium falciparum malaria

artemether

lumefantrine

dispersible tablets

crushed

tablets

lumefantrine

artemether


Input: To report 2 cases of serotonin toxicity (ST) associated with concomitant use of linezolid and serotonergic drugs and review previously published case reports.

associated

2 cases

serotonin toxicity (ST)

concomitant use of linezolid and serotonergic drugs

linezolid

serotonergic

linezolid

serotonergic


Input: This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine.

occur

the hemophagocytic syndrome associated with reactivation of EBV

sulfasalazine

sulfasalazine


Input: Tardive dyskinesia induced by sulpiride.

induced

Tardive dyskinesia

sulpiride

sulpiride


Input: Seizures occurred in two patients with probable Alzheimer's disease who were receiving long-term treatment with metrifonate, an irreversible acetylcholinesterase inhibitor.

occurred

two patients with probable Alzheimer's disease

two

Seizures

long-term treatment with metrifonate

Alzheimer's disease

metrifonate


Input: High-dose antithrombin III was associated with an increased risk of hemorrhage when administered with heparin.

increased

hemorrhage

High-dose antithrombin III

heparin

High-dose

antithrombin III

heparin

antithrombin III

heparin


Input: With the increasing use of Cyclosporine A in transplant patients, the incidence of herpes esophagitis may increase.

incidence

transplant patients

transplant

herpes esophagitis may increase.

Cyclosporine A

Cyclosporine A


Input: After starting nevirapine treatment, nine out of ten patients experienced symptoms of abstinence syndrome, and methadone dose had to be increased by 20% on average during the course of the study.

experienced

nine out of ten patients

nine out of ten

abstinence syndrome

nevirapine

nevirapine


Input: Treatment was begun with amphotericin B-deoxycholate but renal toxicity signs led to its substitution by fluconazole.

signs

renal toxicity

amphotericin B-deoxycholate

amphotericin B-deoxycholate

fluconazole


Input: Post marketing studies of Interferon-beta (IFN beta) therapy in multiple sclerosis (MS) have demonstrated surprisingly high rates of hepatotoxicity.

demonstrated

hepatotoxicity

Interferon-beta

Interferon-beta (IFN beta)


Input: We describe the first case of disseminated salmonellosis in a patient treated with temozolomide.

in

a patient

disseminated salmonellosis

temozolomide

temozolomide


Input: OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction.

related

exacerbated mania

interaction between lopinavir/ritonavir and valproic acid

lopinavir

ritonavir

valproic acid

valproic acid

lopinavir

ritonavir


Input: The first reported case, in an adult, of cholestyramine induced hyperchloremic metabolic acidosis is a 70 year old female with a two year history of primary biliary cirrhosis confirmed by histologic and immunologic criteria.

induced

a 70 year old female with a two year history of primary biliary cirrhosis

70 year old

female

hyperchloremic metabolic acidosis

cholestyramine

cholestyramine

primary biliary cirrhosis


Input: We report a case of fatal C. neoformans fungemia in a neutropenic patient with a history of chronic lymphocytic leukemia treated with alemtuzumab.

treated with

a neutropenic patient with a history of chronic lymphocytic leukemia

fatal C. neoformans fungemia

alemtuzumab

alemtuzumab

chronic lymphocytic leukemia


Input: Aggressive hydration, urinary alkalinization, and leucovorin were continued during the period of elevated methotrexate levels, with the patient receiving a course of hemodialysis and a dose of carboxypeptidase G2.

continued

the patient

Aggressive hydration, urinary alkalinization, and leucovorin

elevated methotrexate

course of hemodialysis and a dose of carboxypeptidase G2

leucovorin

methotrexate

carboxypeptidase G2

a dose


Input: Acute myocardial infarction due to coronary spasm associated with L-thyroxine therapy.

associated

Acute myocardial infarction due to coronary spasm

L-thyroxine

L-thyroxine


Input: Only patients on DT-PACE but not DCEP-T experienced an increased incidence of DVT.

experienced

patients

an increased incidence of DVT

DT-PACE but not DCEP-T

DT-PACE

DCEP-T


Input: To our knowledge, this is the first published report of a possible drug interaction in a critically ill patient receiving concomitant linezolid and rifampin.

receiving

a critically ill patient

critically ill

drug interaction

concomitant linezolid and rifampin

linezolid

rifampin

linezolid

rifampin


Input: Within 24 hours of fluid restriction and cessation of desmopressin, her symptoms and hyponatremia resolved.

resolved.

her

her

symptoms and hyponatremia

24 hours of fluid restriction and cessation of desmopressin

24 hours

desmopressin


Input: An adverse reaction to IFN was strongly suspected as the cause of CHF.

cause

CHF

IFN

IFN


Input: A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.

experienced

A 51-year old physically fit woman

51-year old

woman

angio-oedema and hypotensive shock

irbesartan ingestion

irbesartan

ingestion


Input: Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.

correlated

CBDCA hypersensitivity

total dose of previously administered platinum agents

platinum agents


Input: Lansoprazole-induced thrombocytopenia.

induced

thrombocytopenia

Lansoprazole

Lansoprazole


Input: Cutaneous necrosis as a result of interferon alfa is an infrequent complication with unknown pathogenesis, in which a cutaneous local immune-mediated inflammatory process might be involved.

result

Cutaneous necrosis

interferon alfa

interferon alfa


Input: Torsade de pointes resulting from the addition of droperidol to an existing cytochrome P450 drug interaction.

resulting

Torsade de pointes

droperidol

cytochrome P450

droperidol

cytochrome P450


Input: Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus.

induced

hypersensitivity syndrome and hemophagocytic syndrome

Sulfasalazine

Sulfasalazine


Input: OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease.

during

a patient with the specific genetic susceptibility associated with the thyroid disease

specific genetic susceptibility

Hashimoto's disease

interferon-alpha (IFN-alpha) treatment

interferon-alpha

chronic viral C hepatitis


Input: Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.

complication

Nephrogenic diabetes insipidus (NDI)

lithium

lithium


Input: Serotonin toxicity associated with concomitant use of linezolid.

associated

Serotonin toxicity

concomitant use of linezolid

Serotonin

linezolid

Serotonin

Serotonin

linezolid


Input: We report the case of a 30-year-old male after kidney transplantation, treated with steroids, cyclosporin A and SRL, with steroid-resistant acute rejection in anamnesis.

after

the case of a 30-year-old male

male

steroid-resistant acute rejection

kidney transplantation, treated with steroids, cyclosporin A and SRL

steroids

cyclosporin A

SRL

steroids

cyclosporin A

SRL


Input: Infants are particularly susceptible to chronic nitrate-induced methemoglobinemia because of their low stomach acid production, large numbers of nitrite-reducing bacteria, and the relatively easy oxidation of fetal hemoglobin.

induced

Infants

Infants

methemoglobinemia

nitrate

nitrate


Input: A 72-year-old woman with renal insufficiency who was taking oral pilsicainide (150 mg/d) complained of feeling faint 3 days after she was prescribed oral cetirizine (20 mg/d).

complained

A 72-year-old woman with renal insufficiency

renal insufficiency

woman

feeling faint

taking oral pilsicainide (150 mg/d)

3 days after she was prescribed oral cetirizine (20 mg/d)

oral

oral

pilsicainide

cetirizine

150 mg/d

20 mg/d

3 days

cetirizine

pilsicainide


Input: Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia.

associated

QT prolongation and refractory ventricular arrhythmia

Chronic hydroxychloroquine

hydroxychloroquine


Input: This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.

consistent

patients

clozapine was switched to risperidone and vice versa

elevated serum triglyceride levels

clozapine

risperidone


Input: Sensorimotor polyneuropathy with 5-aminosalicylic acid: a case report.

with

a case

Sensorimotor polyneuropathy

5-aminosalicylic acid

5-aminosalicylic acid


Input: Hydrocortisone prophylaxis and verapamil therapy were the primary therapies used in patient 1 (the only survivor).

therapies

patient 1 (the only survivor)

Hydrocortisone prophylaxis and verapamil therapy

Hydrocortisone

verapamil


Input: The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently.

after

classical transient global amnesia

a more or less extensive retrograde amnesia

clioquinol

clioquinol


Input: We report a case of AILD in an 80-year-old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration.

presented

a case of AILD in an 80-year-old male

AILD

male

generalized pruritic maculopapular eruption and fever

doxycycline administration

doxycycline


Input: OBJECTIVE: To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone.

during

an adolescent girl with a mitochondrial disorder and depression

adolescent

girl

new-onset psychotic and increased mood symptoms

risperidone

risperidone

mitochondrial disorder

depression


Input: Young children undergoing cisplatin chemotherapy are known to be at risk for progressive sensorineural hearing loss.

risk

Young children

Young

children

progressive sensorineural hearing loss

undergoing cisplatin chemotherapy

cisplatin

chemotherapy


Input: Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).

after

Systemic capillary leak syndrome

granulocyte colony-stimulating factor (G-CSF)

granulocyte colony-stimulating factor


Input: CASE SUMMARIES: Two patients who received ifosfamide-containing chemotherapy developed NCSE.

developed

Two patients

Two

NCSE

ifosfamide-containing chemotherapy

ifosfamide

chemotherapy


Input: One of the monohydroxy-metabolites has been incriminated with tacrine-induced hepatotoxicity.

induced

hepatotoxicity

tacrine

tacrine


Input: BACKGROUND: To assess the nature, incidence, and risk factors of retinopathy associated with pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients.

associated

chronic hepatitis C patients

retinopathy

pegylated interferon and ribavirin combination therapy

ribavirin

pegylated interferon

chronic hepatitis C

ribavirin

pegylated interferon


Input: Thrombogenic activity of doxorubicin in myeloma patients receiving thalidomide: implications for therapy.

receiving

myeloma patients

Thrombogenic activity

doxorubicin

thalidomide

myeloma

doxorubicin

thalidomide


Input: Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.

associated

end stage renal disease (ESRD) patients

Agranulocytosis

prolonged vancomycin therapy

prolonged

vancomycin

end stage renal disease (ESRD)


Input: Thiopurine methyltransferase deficiency occurs at a frequency of one in 300 and is associated with profound myelosuppression after a short course of azathioprine.

after

profound myelosuppression

a short course of azathioprine

azathioprine

a short course


Input: Hypotension and sinus arrest with nifedipine in pulmonary hypertension.

with

Hypotension and sinus arrest

nifedipine

nifedipine

pulmonary hypertension


Input: We describe children and adolescents with chronic hematologic and oncologic diseases who exhibited drug-seeking behavior or anticholinergic symptoms with the use of diphenhydramine.

exhibited

children and adolescents with chronic hematologic and oncologic diseases

children

adolescents

drug-seeking behavior or anticholinergic symptoms

diphenhydramine

diphenhydramine

chronic hematologic and oncologic diseases


Input: Transient central diabetes insipidus in the setting of underlying chronic nephrogenic diabetes insipidus associated with lithium use.

associated

Transient central diabetes insipidus

lithium

chronic nephrogenic diabetes insipidus

lithium


Input: A macrophage activation syndrome, possibly related to methotrexate toxicity, developed in a boy with systemic juvenile rheumatoid arthritis.

developed

a boy with systemic juvenile rheumatoid arthritis

boy

macrophage activation syndrome

methotrexate toxicity

methotrexate

systemic juvenile rheumatoid arthritis


Input: Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.

treated

patients

Hyponatremia

lorcainide

lorcainide


Input: Electrical proarrhythmia with procainamide: a new ICD-drug interaction.

with

Electrical proarrhythmia

procainamide

procainamide


Input: To report a case of QT prolongation associated with concomitant cyclobenzaprine and fluoxetine administration followed by torsade de pointes potentiated by droperidol.

associated

QT prolongation

concomitant cyclobenzaprine and fluoxetine administration

cyclobenzaprine

fluoxetine

cyclobenzaprine

fluoxetine


Input: It is presumed that her hyperchloremic metabolic acidosis was secondary to cholestyramine because of the similarity to pediatric reports; the rapid and lasting response to intravenous sodium bicarbonate; the absence of another etiology; normal serum potassium, chloride and bicarbonate despite continued spironolactone therapy after recovery.

secondary

hyperchloremic metabolic acidosis

cholestyramine

cholestyramine


Input: Azathioprine can cause severe myelosuppression.

cause

severe myelosuppression

Azathioprine

Azathioprine


Input: Secretory endometrial adenocarcinoma in a patient on tamoxifen for breast cancer: a report of a case.

on

a patient

Secretory endometrial adenocarcinoma

tamoxifen for breast cancer

breast cancer

tamoxifen


Input: It was postulated that the allergic reaction was most likely caused by capecitabine or the intermediate metabolites based on the immediate reappearance of symptoms from the rechallenge, pharmacokinetic data, and well-tolerance of fluorouracil.

caused

allergic reaction

capecitabine or the intermediate metabolites

capecitabine


Input: Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.

after

Anterior lumbosacral radiculopathy

intrathecal methotrexate

methotrexate

intrathecal


Input: Divalproex sodium-induced eosinophilic pleural effusion.

induced

eosinophilic pleural effusion

Divalproex sodium

Divalproex sodium


Input: A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.

after

A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year

man

Japanese

diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C

salazosulfapyridine

ulcerative colitis

one day

salazosulfapyridine


Input: Amphotericin B-induced seizures in a patient with AIDS.

induced

a patient with AIDS

AIDS

seizures

Amphotericin B

Amphotericin B


Input: Concomitant irradiation apparently enhanced the skin toxicity of aminoglutethimide or possibly aminoglutethimide had a radiosensitizing role in this patient.

enhanced

this patient

skin toxicity

Concomitant irradiation

aminoglutethimide

aminoglutethimide

irradiation

irradiation

aminoglutethimide


Input: CASE DESCRIPTION: A 59-year-old man with known neurocysticercosis developed a large cerebral infarction during praziquantel therapy.

developed

A 59-year-old man with known neurocysticercosis

man

a large cerebral infarction

during praziquantel therapy

neurocysticercosis

praziquantel


Input: We describe a 73-year-old woman who developed serious systemic vasculitis with associated thrombocytopenia in the course of treatment with cladribine.

developed

a 73-year-old woman

woman

systemic vasculitis with associated thrombocytopenia

cladribine

cladribine


Input: All changes disappeared 4 months after the discontinuation of VAD chemotherapy, which further pointed out towards adriamycin and vincristine as possible etiologic agents.

etiologic agents.

All changes

adriamycin and vincristine

adriamycin

vincristine

adriamycin

vincristine


Input: Because of further progression combination treatment of bevacizumab and irinotecan was started and again no liver toxicity was observed.

observed.

liver toxicity

bevacizumab and irinotecan

bevacizumab

irinotecan

bevacizumab

irinotecan


Input: Torsade de pointes represents a potential complication of chronic amiodarone therapy.

complication

Torsade de pointes

chronic amiodarone therapy

amiodarone


Input: Eosinophilia caused by clozapine was observed in challenge, preceded by a faster neutrophil production and consecutive decrease (z = 2.27, p = 0.01).

caused

Eosinophilia

preceded by a faster neutrophil production and consecutive decrease (z = 2.27, p = 0.01)

clozapine

clozapine


Input: The first case is a 69-year-old man who was admitted for depression with psychosis and treated with trazodone, risperidone, and sertraline.

treated

a 69-year-old man who was admitted for depression with psychosis

man

trazodone, risperidone, and sertraline

trazodone

risperidone

sertraline

depression with psychosis

risperidone

sertraline

trazodone


Input: Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.

complications

granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization

propylthiouracil

propylthiouracil


Input: Whether concomitant fluvoxamine treatment reduces tacrine-induced hepatotoxicity needs further study.

induced

hepatotoxicity

tacrine

tacrine


Input: Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy.

after

a patient with radiation pneumonitis and glaucoma

glaucoma

Severe hyperkalemia

prednisone

radiation pneumonitis

prednisone


Input: She was treated with Pancrease MT 16, but had consistent vomiting 1 to 2 hours after administration of enzymes.

after

vomiting

enzymes

Pancrease MT 16

enzymes

1 to 2 hours


Input: Following are two clinical case reports demonstrating profound cerebral edema associated with implantation of Gliadel wafers.

associated

two clinical case

two

profound cerebral edema

implantation of Gliadel wafers

implantation

Gliadel wafers


Input: At this point, a new antifungal agent had been commenced, suggesting a possible drug interaction enhancing the risk of known neurological toxicity with this regime.

suggesting

a possible drug interaction enhancing the risk of known neurological toxicity with this regime

a new antifungal agent

antifungal agent


Input: The knowledge concerning VGB-associated visual dysfunction in pediatric patients, particularly in those who have been exposed to VGB in utero is limited.

associated

pediatric patients

pediatric

visual dysfunction

VGB

VGB


Input: We herein described an additional patient with BCR-ABL (ela2) positive acute lymphoblastic leukemia who developed tumor lysis syndrome after 10-day treatment with imatinib.

developed

patient with BCR-ABL (ela2) positive acute lymphoblastic leukemia

tumor lysis syndrome

10-day treatment with imatinib

imatinib

BCR-ABL (ela2) positive acute lymphoblastic leukemia


Input: Tubulointerstitial nephritis induced by the leukotriene receptor antagonist pranlukast.

induced

Tubulointerstitial nephritis

pranlukast

pranlukast


Input: Two drugs commonly used in triple-drug therapy for treatment of a Helicobacter pylori infection, clarithromycin and omeprazole, have rarely been associated with hypoglycemia when given alone.

associated

hypoglycemia

clarithromycin and omeprazole

clarithromycin

omeprazole

a Helicobacter pylori infection

clarithromycin

omeprazole


Input: We describe the infectious toxicities experienced by the first two patients in our institution treated with dexamethasone (10 mg/m(2)/day for 4 weeks with gradual tapering) during induction according to the dexamethasone arm of BFM 2000 and review the relevant literature that suggests an increased risk of infectious complications with dexamethasone.

experienced by

first two patients in our institution

two

infectious toxicities

treated with dexamethasone (10 mg/m(2)/day for 4 weeks with gradual tapering) during induction according to the dexamethasone arm of BFM 2000

dexamethasone

dexamethasone

10 mg/m(2)/day

4 weeks


Input: This case demonstrates that there is no cross reactivity between glyburide and chlorpropamide in producing hemolytic anemia.

producing

hemolytic anemia

glyburide and chlorpropamide

glyburide

chlorpropamide

glyburide

chlorpropamide


Input: Codeine intoxication in the neonate.

in

neonate

neonate

Codeine intoxication

Codeine

Codeine


Input: However, 1 eye had vitreous hemorrhage after repeated injections of tPA.

after

1 eye had vitreous hemorrhage

repeated injections of tPA

injections

tPA


Input: Dilated cardiomyopathy associated with chronic overuse of an adrenaline inhaler.

associated

Dilated cardiomyopathy

chronic overuse of an adrenaline inhaler

adrenaline

chronic overuse

inhaler


Input: Surgeons and physicians should therefore be aware of the potential for RTA to occur with FK506 after any organ transplantation.

occur

RTA

FK506 after any organ transplantation


Input: Thirty patients with hepatic reactions to cyclofenil, a non-steroidal drug with a stimulating effect on ovulation, are reviewed.

reactions

Thirty patients

Thirty

hepatic

cyclofenil

cyclofenil


Input: Though serotonin syndrome is most often associated with ingestion of more than one serotonergic drug, many other mechanisms have been associated with serotonergic excess.

associated with

serotonin syndrome

ingestion of more than one serotonergic drug

serotonergic drug


Input: Because of a hypersensitivity reaction, initial therapy with penicillin G and gentamicin was stopped and substituted with cefazolin.

with

hypersensitivity reaction

penicillin G

gentamicin

penicillin G

gentamicin

cefazolin

penicillin G

gentamicin


Input: Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.

aware

patients

ocular side effects

hypoalbuminemia and thrombocytopenia

IFN

IFN


Input: The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.

suffering

The third patient

akathisia

risperidone

risperidone


Input: Chlorpropamide-induced hemolytic anemia.

induced

hemolytic anemia

Chlorpropamide

Chlorpropamide


Input: We report recrudescence of imported Plasmodium falciparum malaria following quinine treatment in the context of concurrent phenytoin use.

following

Plasmodium falciparum malaria

quinine treatment in the context of concurrent phenytoin use

quinine

phenytoin

phenytoin

quinine


Input: It is likely that RA contributed to the deterioration in renal function in these patients.

contributed

deterioration in renal function

RA

RA


Input: Marked sinus tachycardia resulting from the synergistic effects of marijuana and nortriptyline.

resulting

Marked sinus tachycardia

marijuana and nortriptyline

marijuana

nortriptyline

marijuana

nortriptyline


Input: Infliximab and its serious adverse effects are discussed, and other cases of osteomyelitis with infliximab use are also reviewed.

with

osteomyelitis

infliximab

infliximab

Infliximab


Input: A new type of minocycline-induced cutaneous hyperpigmentation.

induced

cutaneous hyperpigmentation

minocycline

minocycline


Input: Stroke is an infrequent but recognized complication of heroin addiction.

complication

Stroke

heroin addiction

heroin


Input: Although this type of hyperpigmentation has been previously seen in patients with cancer who are receiving bleomycin, this is, to our knowledge, the first reported case of bleomycin-induced hyperpigmentation in an AIDS patient and should be added to the growing list of cutaneous eruptions seen in these patients.

induced

an AIDS patient

hyperpigmentation

bleomycin

bleomycin

AIDS


Input: Case report of withdrawal dyskinesia associated with amoxapine.

associated

Case

withdrawal dyskinesia

amoxapine

amoxapine


Input: Concern exists that preadmission warfarin use may be associated with an increased risk of intracerebral hemorrhage in patients with ischemic stroke receiving intravenous tissue plasminogen activator, even in those with an international normalized ratio <1.7.

associated

patients with ischemic stroke

increased risk of intracerebral hemorrhage

receiving intravenous tissue plasminogen activator

preadmission warfarin

ischemic stroke

warfarin

intravenous tissue plasminogen activator

warfarin

intravenous tissue plasminogen activator


Input: Transient anuria following administration of angiotensin I-converting enzyme inhibitor (SQ 14225) in a patient with renal artery stenosis of the solitary kidney successfully treated with renal autotransplantation.

following

a patient with renal artery stenosis of the solitary kidney

Transient anuria

angiotensin I-converting enzyme inhibitor (SQ 14225)

renal artery stenosis of the solitary kidney

angiotensin I-converting enzyme inhibitor


Input: Development of essential thrombocythemia in a patient treated with interferon alfa and pentostatin for hairy cell leukemia.

Development

a patient

essential thrombocythemia

interferon alfa and pentostatin

hairy cell leukemia

interferon alfa

pentostatin

interferon alfa

pentostatin


Input: A case of SIADH induced by mizoribin administration.

induced

A case

SIADH

mizoribin administration

mizoribin


Input: The agranulocytosis was rapidly resolved by granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin.

resolved

agranulocytosis

granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin

granulocyte colony-stimulating factor

vancomycin


Input: A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.

developed

A patient

myoclonus

methadone

cancer-associated pain

methadone


Input: These cases were considered unusual in light of the short delay of their onset after initiation of immunosuppressive therapy and their fulminant course: 3 of these patients died of PCP occurring during the first month of treatment with prednisone.

died

3 of these patients

PCP

first month of treatment with prednisone

first month

prednisone


Input: Five days after the fourth dose of vincristine, she presented with bilateral ptosis.

presented

she

she

bilateral ptosis

Five days after the fourth dose of vincristine

Five days

vincristine


Input: As it had been 10 months since her last dosage adjustment of diltiazem, it was unlikely that the statin-induced rhabdomyolysis was precipitated by diltiazem.

precipitated

statin-induced rhabdomyolysis

diltiazem

diltiazem


Input: After the chlorambucil was discontinued, the wbc count began to slowly rise and the patient developed clinical AML.

developed

the patient

wbc count began to slowly rise

clinical AML

chlorambucil

chlorambucil


Input: She received 3.8 mg cumulative dose of vincristin before development of ptosis.

development

She

She

ptosis

3.8 mg cumulative dose of vincristin

3.8 mg

vincristin


Input: In addition, the tachycardia persisted and was repeatedly spontaneously reinitiated for prolonged periods after procainamide.

after

tachycardia persisted and was repeatedly spontaneously reinitiated for prolonged periods

procainamide

procainamide


Input: One patient had a lower average heart rate and two patients had lower average mean blood pressure values during propranolol treatment, none of which was clinically significant.

during

two patients

two

lower average mean blood pressure values

propranolol

propranolol


Input: We have successfully overcome severe neutropenia in an RA patient treated with gold salts, using granulocyte colony-stimulating factor (G-CSF), reducing the duration of neutropenia and risk of infection.

overcome

an RA patient treated with gold salts

RA

reducing the duration of neutropenia and risk of infection

granulocyte colony-stimulating factor (G-CSF)

severe neutropenia

granulocyte colony-stimulating factor


Input: A third patient experienced disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition after receiving paclitaxel.

experienced

A third patient

disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition

paclitaxel

paclitaxel


Input: While 40 mg/day of prednisolone improved hepatic dysfunction dramatically, her diabetic milieu deteriorated seriously.

deteriorated

diabetic milieu deteriorated

40 mg/day of prednisolone

hepatic dysfunction

prednisolone

40 mg/day


Input: Acute renal insufficiency is known to occur in patients who are taking ciprofloxacin, particularly the elderly.

occur

patients

elderly

elderly

Acute renal insufficiency

ciprofloxacin

ciprofloxacin


Input: A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy.

developed

61-year-old man

man

clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis

26 months of procainamide therapy

procainamide

26 months


Input: We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).

induced

a 2-year-old child

2-year-old child

thrombocytopenia and subsequent hemorrhagic complications

heparin

heparin


Input: Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.

relation

Laryngeal dyspnea

acenocoumarol

topical econazole lotion

acenocoumarol

topical econazole

acenocoumarol

topical econazole


Input: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.

received

A 46-year old man with a chronic hepatitis C virus infection

46-year old

man

triple therapy with ribavirin, pegylated interferon and telaprevir

a chronic hepatitis C virus infection

ribavirin

pegylated interferon

telaprevir

ribavirin

pegylated interferon

telaprevir


Input: Leishmania infantum leishmaniasis in corticosteroid--treated patients.

treated

Leishmania infantum leishmaniasis

corticosteroid

corticosteroid


Input: The patient developed occipital infarcts and was found to have extremely elevated levels of PPA in his blood and dialysis fluid.

developed

The patient

occipital infarcts

extremely elevated levels of PPA

PPA


Input: As atypical antipsychotics are increasingly used in the treatment of childhood behavioural disorders either as monotherapy or in combination with other medications, there is a need to know more about their safety, in particular during switching to and from methylphenidate treatment, as antipsychotics and methylphenidate have opposing effects on dopaminergic neurotransmission.

treatment

atypical antipsychotics

as monotherapy or in combination with other medications

childhood behavioural disorders

atypical antipsychotics


Input: Sensory neuropathy revealing necrotizing vasculitis during infliximab therapy for rheumatoid arthritis.

during

Sensory neuropathy revealing necrotizing vasculitis

infliximab therapy

infliximab

rheumatoid arthritis


Input: Because etoposide-induced pulmonary toxicity is an uncommon but serious adverse event, clinicians must be vigilant about the possibility of it, so that the optimal treatment can start as soon as possible.

induced

pulmonary toxicity

etoposide

etoposide


Input: On March 13 the patient was again admitted for worsening CHF and was started on continuous dobutamine infusion.

started on

the patient was again admitted for worsening CHF

continuous dobutamine infusion

dobutamine

infusion

continuous


Input: Suspected methotrexate toxicity from omeprazole: a case review of carboxypeptidase G2 use in a methotrexate-experienced patient with methotrexate toxicity and a review of the literature.

from

methotrexate toxicity

omeprazole

omeprazole


Input: We report a 53-year-old-man who developed rippling muscle disease (RMD) 2 months after starting simvastatin therapy for hypercholesterolemia.

developed

a 53-year-old-man

man

rippling muscle disease (RMD)

2 months after starting simvastatin therapy

hypercholesterolemia

simvastatin

2 months


Input: After taking cholestyramine II sachets twice daily for two months she presented with lethargy, confusion and drowsiness.

After

she

lethargy, confusion and drowsiness

cholestyramine II sachets twice daily for two months

cholestyramine II

sachets

twice daily

two months


Input: Escape atrial complexes, which occurred following junctional premature complexes, failed to initiate tachycardia in the control state but tachycardia was always reinitiated by an identical escape sequence after procainamide.

reinitiated

tachycardia

procainamide

procainamide


Input: Ten percent of newly diagnosed myeloma patients treated with any type of chemotherapy develop deep venous thrombosis (DVT).

develop

myeloma patients

deep venous thrombosis (DVT)

any type of chemotherapy

myeloma

chemotherapy


Input: In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.

adverse effect

the first case

SIADH

mizoribin

mizoribin


Input: Isoniazid and ethambutol as a cause of optic neuropathy.

cause

optic neuropathy

Isoniazid and ethambutol

Isoniazid

ethambutol

Isoniazid

ethambutol


Input: Fluorouracil for allergic reactions to capecitabine.

to

allergic reactions

capecitabine

capecitabine


Input: Administration of pyridoxine to an infant after a long period of convulsions was followed by acute hypotonia.

followed

an infant

infant

acute hypotonia

pyridoxine

pyridoxine

convulsions


Input: Acute pancreatitis in a child with idiopathic ulcerative colitis on long-term 5-aminosalicylic acid therapy.

in

a child with idiopathic ulcerative colitis

child

Acute pancreatitis

long-term 5-aminosalicylic acid therapy

5-aminosalicylic acid

idiopathic ulcerative colitis

long-term


Input: High-dose antithrombin III in severe sepsis: a randomized controlled trial.

in

High-dose antithrombin III

severe sepsis

High-dose

antithrombin III


Input: Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.

following

Fatal interstitial pneumonitis

high-dose intermittent chlorambucil therapy

high-dose

chlorambucil

chronic lymphocyte leukemia


Input: These findings suggest that the corneal and retinal changes are the result of a toxic effect of tamoxifen when used in the doses and duration described.

result

corneal and retinal changes

tamoxifen

tamoxifen


Input: Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).

include

nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence)

lacosamide doses up to 600 mg/day

lacosamide

600 mg/day


Input: We report two cases of serotonin syndrome in elderly patients during treatment of psychotic depression with atypical antipsychotics and antidepressants.

during

elderly patients

elderly

serotonin syndrome

atypical antipsychotics and antidepressants

psychotic depression

atypical antipsychotics

antidepressants

atypical antipsychotics

antidepressants


Input: Piritrexim-induced pulmonary toxicity.

induced

pulmonary toxicity

Piritrexim

Piritrexim


Input: Progression of chronic myeloid leukemia to blast crisis during treatment with imatinib mesylate.

during

Progression of chronic myeloid leukemia to blast crisis

imatinib mesylate

imatinib mesylate


Input: Presentation of three palliative care patients who were given ketamine as an analgesic and subsequently developed significant and debilitating urological symptoms.

developed

three palliative care patients

three

urological symptoms

ketamine

ketamine


Input: A 52 year-old male patient diagnosed of ankylosing spondylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate.

presented

A 52 year-old male patient diagnosed of ankylosing spondylitis

52 year-old

male

an iron deficiency anemia

a ten-month treatment of methotrexate

ten-month

methotrexate

ankylosing spondylitis


Input: The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.

after

opportunistic infections

immunosuppressive therapy with alemtuzumab

alemtuzumab


Input: Clinicians should be aware of the dysrhythmic potential of cyclobenzaprine and fluoxetine, monitor for other cytochrome P450 inhibitors, and avoid concomitant drugs known to prolong the QT interval.

potential

dysrhythmic

cyclobenzaprine and fluoxetine

cyclobenzaprine

fluoxetine

cyclobenzaprine

fluoxetine


Input: Acute generalized exanthematous pustulosis induced by salazosulfapyridine in a patient with ulcerative colitis.

induced

a patient with ulcerative colitis

Acute generalized exanthematous pustulosis

salazosulfapyridine

salazosulfapyridine

ulcerative colitis


Input: CONCLUSION: Acetic acid is corrosive and may cause vagina bleeding.

cause

vagina bleeding

Acetic acid

Acetic acid


Input: We report a case admitted with a first-detected, symptomatic paroxysmal atrial fibrillation in a healthy patient after self-medication with vardenafil.

after

a healthy patient

symptomatic paroxysmal atrial fibrillation

vardenafil

vardenafil


Input: Propranolol: an unrecognized cause of central nervous system dysfunction in patients undergoing cardiopulmonary bypass.

cause

patients undergoing cardiopulmonary bypass

cardiopulmonary bypass

central nervous system dysfunction

Propranolol

Propranolol


Input: CONCLUSIONS: Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib.

associated with

Symptoms and pathologic changes of colitis

rofecoxib

rofecoxib

exposure


Input: A possible drug-drug interaction between IFN alfa 11 MU TIW and gemfibrozil 600 mg BID was reported in a patient undergoing treatment for IFN-induced hypertriglyceridemia.

reported

a patient

IFN-induced hypertriglyceridemia

drug-drug interaction between IFN alfa 11 MU TIW and gemfibrozil 600 mg BID

IFN alfa

gemfibrozil

600 mg

11 MU

BID

TIW

IFN alfa

gemfibrozil


Input: Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine.

treatment

Systemic vasculitis

cladribine

hairy cell leukaemia

cladribine


Input: Quinine is universally used for the very common symptom of night leg cramps.

used

Quinine

Quinine

night leg cramps


Input: However, continued low-dose MTX led, in spite of normal liver tests, 8 years after the last biopsy to liver failure and death in 1 of our patients.

led,

liver failure and death

low-dose MTX

MTX

low-dose


Input: Antithrombin III may provide protection from multiorgan failure and improve survival in severely ill patients.

provide protection

severely ill patients

Antithrombin III

multiorgan failure

multiorgan failure

severely ill

Antithrombin III


Input: In the second case, five cardiac arrests due to ventricular tachycardia and fibrillation occurred during several hours after beginning a trial of bretylium maintenance therapy for complex ventricular ectopy.

occurred

In the second case

five cardiac arrests due to ventricular tachycardia and fibrillation

several hours after beginning a trial of bretylium maintenance therapy

complex ventricular ectopy

several hours after

bretylium


Input: The association of central diabetes insipidus (CDI) with lithium use is rare.

association

central diabetes insipidus (CDI)

lithium

lithium


Input: However, a new episode of neutropenia, with a WBC count of 2.8 x 10(3)/mm3 and ANC of 0.448 x 10(3)/mm3, occurred 11 days after teicoplanin initiation.

occurred

neutropenia, with a WBC count of 2.8 x 10(3)/mm3 and ANC of 0.448 x 10(3)/mm3

11 days after teicoplanin initiation

11 days

teicoplanin


Input: In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity, even at lower doses, which resulted in two drug-related deaths.

observed

patients with breast cancer

hepatotoxicity

hycanthone

hycanthone

breast cancer

lower doses


Input: This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.

provoked

adolescent patients

adolescent

non-convulsive status epilepticus

tiagabine

tiagabine


Input: Two patients are described who developed sensory neuropathy after the ingestion of 30.6 and 114 g metronidazole respectively.

after

Two patients

Two

sensory neuropathy

the ingestion of 30.6 and 114 g metronidazole

metronidazole

114 g

g


Input: We report two young patients with cystic fibrosis who presented with acute renal insufficiency after 2-3 weeks of oral ciprofloxacin therapy.

presented

two young patients with cystic fibrosis

two

young

acute renal insufficiency

2-3 weeks of oral ciprofloxacin therapy

cystic fibrosis

2-3 weeks

ciprofloxacin

oral


Input: A 37-year-old male with multiple myeloma received citalopram 40 mg/day and trazodone 150 mg/day for anxiety-related disorders.

for

A 37-year-old male with multiple myeloma

male

multiple myeloma

citalopram 40 mg/day and trazodone 150 mg/day

anxiety-related disorders

citalopram

trazodone

40 mg/day

150 mg/day

citalopram

trazodone


Input: Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease.

during

a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease

specific genetic susceptibility to the thyroid disease

Hashimoto's disease

interferon-alpha

interferon-alpha


Input: Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.

adverse reaction

Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis

minocycline

minocycline


Input: CONCLUSIONS: This observation of "on-off" risperidone treatment suggests that risperidone may have worsened both psychiatric and physical manifestations of the mitochondrial disorder in this adolescent.

have worsened

mitochondrial disorder in this adolescent

adolescent

mitochondrial disorder

psychiatric and physical manifestations

risperidone

risperidone


Input: The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.

following

non-convulsive status epilepticus subsided

reduction in tiagabine dosages

tiagabine


Input: CONCLUSIONS: For all patients with vancomycin-induced neutropenia, possible cross-reactivity of teicoplanin should be monitored.

induced

patients

neutropenia

vancomycin

vancomycin

teicoplanin

teicoplanin

vancomycin


Input: Methotrexate induced sprue-like syndrome.

induced

sprue-like syndrome

Methotrexate

Methotrexate


Input: Because of the described effects of niacin on the coagulation cascade and the possibility for pharmacokinetic interactions, there is a potential for synergistic coagulopathy when combined with warfarin therapy.

potential

synergistic coagulopathy

niacin

combined with warfarin therapy

niacin

warfarin

warfarin

niacin


Input: The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.

response

electrophysiologic effect

procainamide

procainamide


Input: The former patient had complained once that his visual acuity had decreased after the termination of IFN therapy, and the latter patient complained twice during IFN therapy that his visual acuity had decreased.

after

The former patient

visual acuity had decreased

IFN

IFN


Input: Despite administration of phenytoin and lorazepam, the seizures persisted and occurred only during amphotercin B administration.

during

seizures

amphotercin B

amphotercin B


Input: We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis.

after

a patient who presented with bloody diarrhoea

osteoarthritis

bloody diarrhoea

15 mg meloxicam daily for 10 days

15 mg

meloxicam

daily

osteoarthritis

10 days


Input: In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.

occurred

first patient

two episodes of ventricular tachycardia requiring cardioversion

close temporal sequence with administering bretylium

close temporal sequence

bretylium


Input: Transient phenytoin induced IgA deficiency and permanent IgE increase.

induced

IgA deficiency and permanent IgE increase

phenytoin

phenytoin


Input: Cerebral edema associated with Gliadel wafers: two case studies.

associated

Cerebral edema

Gliadel wafers

Gliadel


Input: Following the development of restless leg syndrome, therapy with clonazepam 0.5 mg qhs was initiated.

therapy

clonazepam 0.5 mg qhs

clonazepam

0.5 mg qhs

restless leg syndrome


Input: We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.

developed

a case of a diabetic patient taking glyburide

prolonged hypoglycemia, which persisted for over 24 hours

ciprofloxacin

glyburide

ciprofloxacin

diabetic

glyburide

ciprofloxacin


Input: We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.

developed

a 74-year-old man with rheumatoid arthritis (RA)

man

syndrome of inappropriate secretion of antidiuretic hormone (SIADH)

1.5 months after commencement of mizoribin prescription

1.5 months after

mizoribin

rheumatoid arthritis


Input: To our knowledge, this is the first case of ivermectin-induced severe liver disease published in the literature.

induced

severe liver disease

ivermectin

ivermectin


Input: This is the first case of hydroxyurea-induced acute interstitial pneumonitis reported in the literature.

induced

acute interstitial pneumonitis

hydroxyurea

hydroxyurea


Input: A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan.

after

A 32-year-old man with a family history of type 2 diabetes mellitus

man

type 2 diabetes mellitus

circulatory collapse and deep coma

9 days of treatment with perospirone hydrochloride

perospirone hydrochloride

after 9 days


Input: CONCLUSION: The chronic use of HCQ for rheumatic diseases, or as an anti-malarial drug, should be balanced against the risk of developing potentially lethal cardiac arrhythmias.

against

lethal cardiac arrhythmias

chronic use of HCQ

rheumatic diseases

HCQ

chronic


Input: Myoclonic spasms following intrathecal morphine.

following

Myoclonic spasms

intrathecal morphine

morphine.


Input: This is the first report of a disulfiram-like reaction with cefmenoxime.

with

disulfiram-like reaction

cefmenoxime

cefmenoxime


Input: To report a case of a probable interaction between warfarin and extended-release niacin that may have led to synergistic coagulopathy and to inform health care providers of a need for more frequent monitoring of international normalized ratio (INR) in patients taking these drugs concomitantly.

led

synergistic coagulopathy

warfarin and extended-release niacin

warfarin

niacin

niacin

warfarin


Input: Dasatinib-induced pleural effusions: a lymphatic network disorder?

induced

pleural effusions

Dasatinib

Dasatinib


Input: This article reports the case of an otherwise healthy patient who experienced permanent sensorineural hearing loss after a brief course of naproxen and reviews the literature on NSAID-related permanent sensorineural hearing loss.

after

an otherwise healthy patient

permanent sensorineural hearing loss

a brief course of naproxen

naproxen

brief course


Input: Administration of steroid and decreasing the dose of PTU produced a good clinical response and the ANCA disappeared.

produced

a good clinical response and the ANCA disappeared

steroid

PTU

steroid

PTU


Input: The second patient exhibited sudden PLMS following olanzapine injection.

following

The second patient

sudden PLMS

olanzapine injection

olanzapine

injection


Input: However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation.

cause

acceleration of the ventricular rate during atrial fibrillation

adenosine

adenosine


Input: A cardiology consultation performed on the day of admission determined that a markedly elevated creatine kinase-myocardial band isoenzyme level and borderline-high troponin I level were diagnostic of rhabdomyolysis secondary to statin use.

secondary

elevated creatine kinase-myocardial band isoenzyme level and borderline-high troponin I level

rhabdomyolysis

statin

statin


Input: METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.

resulted in

vomiting

Viokase and Pancrease MT 16

Viokase

Pancrease MT 16

Viokase

Pancrease MT 16