{"paperId": "10.59350/9pq7c-g5073", "doi": "10.59350/9pq7c-g5073", "title": "Screenager: screening times at bioRxiv", "publicationYear": 2020, "publicationDate": "2020-03-30", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Royle", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/9pq7c-g5073", "pdfUrl": null, "abstract": "When a preprint is uploaded to bioRxiv, it undergoes screening before it appears online. How long does it take for Affiliates to screen preprints at bioRxiv? tl;dr I used R to look at bioRxiv screening times.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1101/777284", "doi": "10.1101/777284", "title": "Files removed following a technical error", "publicationYear": 2019, "publicationDate": "2019-10-17", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "bioRxiv", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/777284", "pdfUrl": null, "abstract": "This manuscript was removed because it posted owing to a technical error", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/hp99g-j5r37", "doi": "10.59350/hp99g-j5r37", "title": "ShoRtcut from bioRxiv to GigaScience", "publicationYear": 2017, "publicationDate": "2017-03-23", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Hans Zauner", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/hp99g-j5r37", "pdfUrl": null, "abstract": "<em> <strong> Authors can now submit their bioRxiv preprints directly to GigaScience via the biorXiv platform, at the push of a button. This handy technical integration is another hallmark of biology preprints becoming a normal, accepted, and speedy way of communicating research results. </strong> </em> Pre-prints, versions of a scholarly paper that precede formal publication in a peer-reviewed journal are  becoming increasingly mainstream.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/v86s3-e7x22", "doi": "10.59350/v86s3-e7x22", "title": "ShoRtcut from bioRxiv to GigaScience", "publicationYear": 2017, "publicationDate": "2017-03-23", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Hans Zauner", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/v86s3-e7x22", "pdfUrl": "https://api.rogue-scholar.org/posts/10.59350/v86s3-e7x22.pdf", "abstract": "<em> <strong> Authors can now submit their bioRxiv preprints directly to GigaScience via the biorXiv platform, at the push of a button. This handy technical integration is another hallmark of biology preprints becoming a normal, accepted, and speedy way of communicating research results. </strong> </em> Pre-prints, versions of a scholarly paper that precede formal publication in a peer-reviewed journal are  becoming increasingly mainstream.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/q8emx-zgr60", "doi": "10.59350/q8emx-zgr60", "title": "Screenager: screening times at bioRxiv", "publicationYear": 2020, "publicationDate": "2020-03-30", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Royle", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/q8emx-zgr60", "pdfUrl": null, "abstract": "When a preprint is uploaded to bioRxiv, it undergoes screening before it appears online. How long does it take for Affiliates to screen preprints at bioRxiv? tl;dr I used R to look at bioRxiv screening times.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/xnncd-29243", "doi": "10.59350/xnncd-29243", "title": "White label: the growth of bioRxiv", "publicationYear": 2015, "publicationDate": "2015-12-11", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Royle", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/xnncd-29243", "pdfUrl": null, "abstract": "bioRxiv, the preprint server for biology, recently turned 2 years old. This seems a good point to take a look at how bioRxiv has developed over this time and to discuss any concerns sceptical people may have about using the service.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/g47rj-ep603", "doi": "10.59350/g47rj-ep603", "title": "Over and Over: Preprint revisions on bioRxiv", "publicationYear": 2021, "publicationDate": "2021-04-07", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Royle", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/g47rj-ep603", "pdfUrl": null, "abstract": "The aim of this post is to look at revisions of bioRxiv preprints. I'm interested how long preprint versions exist on bioRxiv. In other words: how long do revisions to preprints take? The data from bioRxiv is a complex dataset with many caveats as I'll explain further down, but some interesting details do emerge.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/r62d8-b9s16", "doi": "10.59350/r62d8-b9s16", "title": "White label: the growth of bioRxiv", "publicationYear": 2015, "publicationDate": "2015-12-11", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Royle", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/r62d8-b9s16", "pdfUrl": null, "abstract": "bioRxiv, the preprint server for biology, recently turned 2 years old. This seems a good point to take a look at how bioRxiv has developed over this time and to discuss any concerns sceptical people may have about using the service.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/xxgtd-nvb53", "doi": "10.59350/xxgtd-nvb53", "title": "Searching medRxiv and bioRxiv Preprint Data", "publicationYear": 2020, "publicationDate": "2020-10-20", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Luke McGuinness", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/xxgtd-nvb53", "pdfUrl": null, "abstract": "Background & motivation medRxiv, as the preprint repository for papers in the medical, clinical, and related health sciences, <sup> 1 </sup> has become a central source of new studies related to the COVID-19 pandemic.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/14zwp-04124", "doi": "10.59350/14zwp-04124", "title": "Over and Over: Preprint revisions on bioRxiv", "publicationYear": 2021, "publicationDate": "2021-04-07", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Royle", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/14zwp-04124", "pdfUrl": null, "abstract": "The aim of this post is to look at revisions of bioRxiv preprints. I'm interested how long preprint versions exist on bioRxiv. In other words: how long do revisions to preprints take? The data from bioRxiv is a complex dataset with many caveats as I'll explain further down, but some interesting details do emerge.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/5av02-39j79", "doi": "10.59350/5av02-39j79", "title": "Searching medRxiv and bioRxiv Preprint Data", "publicationYear": 2020, "publicationDate": "2020-10-20", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Luke McGuinness", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/5av02-39j79", "pdfUrl": "https://api.rogue-scholar.org/posts/10.59350/5av02-39j79.pdf", "abstract": "Background & motivation medRxiv, as the preprint repository for papers in the medical, clinical, and related health sciences, <sup> 1 </sup> has become a central source of new studies related to the COVID-19 pandemic.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/83pea-v6z98", "doi": "10.59350/83pea-v6z98", "title": "Ozymandias: A biodiversity knowledge graph available as a preprint on Biorxiv", "publicationYear": 2018, "publicationDate": "2018-12-05", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Roderic Page", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/83pea-v6z98", "pdfUrl": null, "abstract": "I've written up my entry for the 2018 GBIF Challenge (\"Ozymandias\") and posted a preprint on Biorxiv (https://www.biorxiv.org/content/early/2018/12/04/485854). The DOI is https://doi.org/10.1101/485854 which, last time I checked, still needs to be registered. The abstract appears below. I'll let the preprint sit there for a little while before I summon the enthusiasm to revisit it, tidy it up, and submit it for publication.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/y6g6m-f4688", "doi": "10.59350/y6g6m-f4688", "title": "The Rise and Fall: impact of the COVID-19 pandemic on bioRxiv preprints", "publicationYear": 2021, "publicationDate": "2021-03-20", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Royle", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/y6g6m-f4688", "pdfUrl": null, "abstract": "As the COVID-19 pandemic continues, different countries are experiencing various restrictions including lockdowns. Some of these restrictions alter our ability to do science: by hindering lab access or taking time away from researchers for homeschooling. So, what impact has the pandemic had on scientific output?", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/zar9k-43785", "doi": "10.59350/zar9k-43785", "title": "Exploring the bioRxiv API with R, httr2, rvest, tidytext, and Datawrapper", "publicationYear": 2025, "publicationDate": "2025-02-10", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen D. Turner", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/zar9k-43785", "pdfUrl": null, "abstract": "Collect metadata and publication details for >200k preprints over a 10 year period, investigate trends, and scrape full text for sentiment analysis", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/6q4ez-3kt89", "doi": "10.59350/6q4ez-3kt89", "title": "Exploding, Impacting: looking at bioRxiv preprint view dynamics with R", "publicationYear": 2024, "publicationDate": "2024-09-24", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Royle", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/6q4ez-3kt89", "pdfUrl": "https://api.rogue-scholar.org/posts/10.59350/6q4ez-3kt89.pdf", "abstract": "One of the joys of posting a preprint is seeing that people are viewing, downloading and (hopefully) reading your paper. On bioRxiv you can check out the statistics for your paper in the metrics tab.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.22541/au.153252412.28244185", "doi": "10.22541/au.153252412.28244185", "title": "PREreview of bioRxiv article “Subfamily-specific functionalization of diversified immune receptors in wild barley”", "publicationYear": 2018, "publicationDate": "2018-07-25", "type": "posted-content", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Sophien Kamoun", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22541/au.153252412.28244185", "pdfUrl": null, "abstract": "This is a review of Maekawa et al. bioRxiv 293050; doi: https://doi.org/10.1101/352278 posted on June 20, 2018. In this paper, the authors mined the transcriptomes of 50 different accession of wild barley, generating a rich library of natural variants of the MLA immune receptor—a classical nucleotide-binding domain and leucine-rich repeat-containing (NLR) protein. They grouped the MLA variants in two subfamilies with all receptors known to be effective against the powdery mildew fungus grouping in one subfamily.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/yqc0n-gxn10", "doi": "10.59350/yqc0n-gxn10", "title": "Analyzing Preprints: The challenges of working with metadata from bioRxiv", "publicationYear": 2019, "publicationDate": "2019-10-10", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "ScholCommLab", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 7, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/yqc0n-gxn10", "pdfUrl": null, "abstract": "<strong> By Mario Malički, Maria Janina Sarol, and Juan Pablo Alperin </strong> <em> This blog post is the third in a four part series documenting the methodological challenges we faced during our </em> <em> project </em> <em> investigating preprint growth and uptake. </em>", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1242/prelights.15240", "doi": "10.1242/prelights.15240", "title": "bioRxiv: the preprint server for biology", "publicationYear": 2019, "publicationDate": "2019-11-19", "type": "posted-content", "publisher": "The Company of Biologists", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Jonny Coates", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1242/prelights.15240", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1242/prelights.7905", "doi": "10.1242/prelights.7905", "title": "Tracking the popularity and outcomes of all bioRxiv preprints", "publicationYear": 2019, "publicationDate": "2019-01-30", "type": "posted-content", "publisher": "The Company of Biologists", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Gautam Dey", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1242/prelights.7905", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/mq5ye-p7c14", "doi": "10.59350/mq5ye-p7c14", "title": "Llama 3.2 summaries of bioRxiv and medRxiv preprints with biorecap", "publicationYear": 2024, "publicationDate": "2024-09-26", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen D. Turner", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/mq5ye-p7c14", "pdfUrl": "https://api.rogue-scholar.org/posts/10.59350/mq5ye-p7c14.pdf", "abstract": "The biorecap package can now summarize bioRxiv and medRxiv preprints, and uses the llama-3.2-3b model by default.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/7jf02-j3e58", "doi": "10.59350/7jf02-j3e58", "title": "Exploding, Impacting: looking at bioRxiv preprint view dynamics with R", "publicationYear": 2024, "publicationDate": "2024-09-24", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Royle", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/7jf02-j3e58", "pdfUrl": null, "abstract": "One of the joys of posting a preprint is seeing that people are viewing, downloading and (hopefully) reading your paper. On bioRxiv you can check out the statistics for your paper in the metrics tab.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/f09fr-rq427", "doi": "10.59350/f09fr-rq427", "title": "Llama 3.2 summaries of bioRxiv and medRxiv preprints with biorecap", "publicationYear": 2024, "publicationDate": "2024-09-26", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen D. Turner", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/f09fr-rq427", "pdfUrl": null, "abstract": "The biorecap package can now summarize bioRxiv and medRxiv preprints, and uses the llama-3.2-3b model by default.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.22541/au.156460759.93613361", "doi": "10.22541/au.156460759.93613361", "title": "PREreview of bioRxiv article \"A generalist pathogen view of diverse host evolutionary histories through polygenic virulence\"", "publicationYear": 2019, "publicationDate": "2019-07-31", "type": "posted-content", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Sophien Kamoun", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22541/au.156460759.93613361", "pdfUrl": null, "abstract": "This is a review of Caseys et al. bioRxiv doi: https://doi.org/10.1101/507491 posted on June 25, 2019. This study aims at addressing whether coevolutionary models of host-pathogen interactions apply to a generalist pathogen that exhibits quantitative virulence across a broad range of plants. They generated an exhaustive virulence matrix for the nectrophic fungus Botrytis cinerea on 90 genotypes of 8 plant species. They conclude that this pathosystem doesn’t fit traditional arms-race coevolution models with quantitative variation in susceptibility distinct from the phylogenetic relationships between the examined plants.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/xnhk1-bq814", "doi": "10.59350/xnhk1-bq814", "title": "The Rise and Fall: impact of the COVID-19 pandemic on bioRxiv preprints", "publicationYear": 2021, "publicationDate": "2021-03-20", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Royle", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/xnhk1-bq814", "pdfUrl": null, "abstract": "As the COVID-19 pandemic continues, different countries are experiencing various restrictions including lockdowns. Some of these restrictions alter our ability to do science: by hindering lab access or taking time away from researchers for homeschooling. So, what impact has the pandemic had on scientific output?", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.7490/f1000research.1116822.1", "doi": "10.7490/f1000research.1116822.1", "title": "Tracking the popularity and outcomes of all bioRxiv preprints", "publicationYear": 2019, "publicationDate": "2019-06-03", "type": "posted-content", "publisher": "F1000 Research Ltd", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Richard J. Abdill, Ran Blekhman", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.7490/f1000research.1116822.1", "pdfUrl": null, "abstract": "(Presented by Richard Abdill.) Researchers in the life sciences are posting work to preprint servers at an unprecedented and increasing rate, sharing papers online before (or instead of) publication in peer-reviewed journals. Though the increasing acceptance of preprints is driving policy changes for journals and funders, there is little information about their usage. Here, we collected and analyzed data on all 37,648 preprints uploaded to bioRxiv.org, the largest biology-focused preprint server, in its first five years. We find preprints are being read more than ever before (1.1 million downloads in October 2018 alone) and that the rate of preprints being posted has increased to a recent high of 2,100 per month, driven primarily by exponential growth in the number of papers in neuroscience and bioinformatics. We also find that two-thirds of preprints posted before 2017 were later published in peer-reviewed journals, and that preprints with more downloads tend to appear in journals with a higher impact factor. The age of preprints appearing in journals also differs by publication, with journals such as G3 publishing most preprints within four months of their appearance on bioRxiv. Lastly, we developed Rxivist.org, a web application providing multiple ways of interacting with preprint metadata, including an API and website that allows users to sort preprints related to their interests based on Twitter activity or bioRxiv download metrics.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/ac5v9-9pk08", "doi": "10.59350/ac5v9-9pk08", "title": "Analyzing Preprints: The challenges of working with metadata from bioRxiv", "publicationYear": 2019, "publicationDate": "2019-10-10", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "ScholCommLab", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 7, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/ac5v9-9pk08", "pdfUrl": null, "abstract": "<strong> By Mario Malički, Maria Janina Sarol, and Juan Pablo Alperin </strong> <em> This blog post is the third in a four part series documenting the methodological challenges we faced during our </em> <em> project </em> <em> investigating preprint growth and uptake. </em>", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/a9pcd-7nw25", "doi": "10.59350/a9pcd-7nw25", "title": "biorecap: an R package for summarizing bioRxiv preprints with a local LLM", "publicationYear": 2024, "publicationDate": "2024-08-24", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Turner", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/a9pcd-7nw25", "pdfUrl": "https://api.rogue-scholar.org/posts/10.59350/a9pcd-7nw25.pdf", "abstract": "This is re-posted from my newsletter, where I'll be posting from now on: https://blog.stephenturner.us/p/biorecap-r-package-for-summarizing-biorxiv-preprints-local-llm ---TL;DR I wrote an R package that summarizes recent bioRxiv preprints using a locally running LLM via Ollama+ollamar, and produces a summary HTML report from a parameterized RMarkdown template.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/jw07y-48b02", "doi": "10.59350/jw07y-48b02", "title": "Ozymandias: A biodiversity knowledge graph available as a preprint on Biorxiv", "publicationYear": 2018, "publicationDate": "2018-12-05", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Roderic Page", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/jw07y-48b02", "pdfUrl": "https://api.rogue-scholar.org/posts/10.59350/jw07y-48b02.pdf", "abstract": "I've written up my entry for the 2018 GBIF Challenge (\"Ozymandias\") and posted a preprint on Biorxiv (https://www.biorxiv.org/content/early/2018/12/04/485854). The DOI is https://doi.org/10.1101/485854 which, last time I checked, still needs to be registered. The abstract appears below. I'll let the preprint sit there for a little while before I summon the enthusiasm to revisit it, tidy it up, and submit it for publication.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/qbh61-w9c06", "doi": "10.59350/qbh61-w9c06", "title": "biorecap: an R package for summarizing bioRxiv preprints with a local LLM", "publicationYear": 2024, "publicationDate": "2024-08-24", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen D. Turner", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/qbh61-w9c06", "pdfUrl": null, "abstract": "The biorecap package summarizes bioRxiv preprints using a local LLM. I used two LLMs to help me write the package, and two other LLMs to help me write a paper about the package, published on arXiv.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.22541/au.156173835.50161858", "doi": "10.22541/au.156173835.50161858", "title": "PREreview of bioRxiv article “Convergent evolution of effector protease recognition by Arabidopsis and barley”", "publicationYear": 2019, "publicationDate": "2019-06-28", "type": "posted-content", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Sophien Kamoun", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22541/au.156173835.50161858", "pdfUrl": null, "abstract": "This is a review of Carter, Helm et al. bioRxiv 374264; doi: https://doi.org/10.1101/374264 posted on July 23, 2018. In this paper, the authors showed that diverse barley cultivars are able to respond to the Pseudomonas syringae effector AvrPphB and they characterized both the effector target (PBS1) and the receptor (PBR1) responsible for this recognition. Furthermore, their phylogenetic analyses revealed that the immune receptor involved in this response is not orthologous to a previously characterized receptor (RPS5) from Arabidopsis thaliana that has a functionally analogous AvrPphB recognition mechanism. This leads the authors to conclude that recognition of the AvrPphB protease has evolved independently in Arabidopsis and barley.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/wztpw-wey45", "doi": "10.59350/wztpw-wey45", "title": "Exploring the bioRxiv API with R, httr2, rvest, tidytext, and Datawrapper", "publicationYear": 2025, "publicationDate": "2025-02-10", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen D. Turner", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/wztpw-wey45", "pdfUrl": "https://api.rogue-scholar.org/posts/10.59350/wztpw-wey45.pdf", "abstract": "Collect metadata and publication details for >200k preprints over a 10 year period, investigate trends, and scrape full text for sentiment analysis", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/8vtcm-c5c82", "doi": "10.59350/8vtcm-c5c82", "title": "biorecap: an R package for summarizing bioRxiv preprints with a local LLM", "publicationYear": 2024, "publicationDate": "2024-08-24", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen D. Turner", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/8vtcm-c5c82", "pdfUrl": "https://api.rogue-scholar.org/posts/10.59350/8vtcm-c5c82.pdf", "abstract": "The biorecap package summarizes bioRxiv preprints using a local LLM. I used two LLMs to help me write the package, and two other LLMs to help me write a paper about the package, published on arXiv.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1242/prelights.12267", "doi": "10.1242/prelights.12267", "title": "The effect of bioRxiv preprints on citations and altmetrics", "publicationYear": 2019, "publicationDate": "2019-07-18", "type": "posted-content", "publisher": "The Company of Biologists", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Jonny Coates", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1242/prelights.12267", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.22541/au.156259046.61263831", "doi": "10.22541/au.156259046.61263831", "title": "PREreview of bioRxiv article “Structure-function analysis of ZAR1 immune receptor reveals key molecular interactions for activity”", "publicationYear": 2019, "publicationDate": "2019-07-08", "type": "posted-content", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Sophien Kamoun", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22541/au.156259046.61263831", "pdfUrl": null, "abstract": "This is a review of Baudin, Schreiber, Martin et al. bioRxiv doi: https://doi.org/10.1101/592824 posted on March 29, 2019. The authors used structural modelling to identify elements required for self-association of the NLR immune receptor ZAR1, specifically its N-terminal CC-domain ZAR1CC. They discovered that the N-terminal α1 helix and EDVID motif in ZAR1CC are important for oligomerization and function of ZAR1. This complements recent findings by Wang et al. (2019) based on cryo-EM structures, highlighting the importance of the α1 helix for the activity of ZAR1 although some differences were noted that could reflect the different experimental set ups (CC domain vs full-length protein) as discussed in the paper.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.22541/au.158680337.76671114", "doi": "10.22541/au.158680337.76671114", "title": "PREreview of bioRxiv article “The vesicular trafficking system component MIN7 is required for minimizing Fusarium graminearum infection”", "publicationYear": 2020, "publicationDate": "2020-04-13", "type": "posted-content", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Matthew Helm", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22541/au.158680337.76671114", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.22541/au.158217227.77505452", "doi": "10.22541/au.158217227.77505452", "title": "Pre-print journal club review of BioRxiv article: Uncovering the hidden antibiotic potential of Cannabis", "publicationYear": 2020, "publicationDate": "2020-02-20", "type": "posted-content", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Craig McCormick", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22541/au.158217227.77505452", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.22541/au.157530334.44787108", "doi": "10.22541/au.157530334.44787108", "title": "PREreview of bioRxiv article “Roq1 confers resistance to Xanthomonas, Pseudomonas syringae and Ralstonia solanacearum in tomato”", "publicationYear": 2019, "publicationDate": "2019-12-02", "type": "posted-content", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Matthew Helm", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22541/au.157530334.44787108", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.59350/q35zx-zf568", "doi": "10.59350/q35zx-zf568", "title": "biorecap: an R package for summarizing bioRxiv preprints with a local LLM", "publicationYear": 2024, "publicationDate": "2024-08-24", "type": "posted-content", "publisher": "Front Matter", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Turner", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.59350/q35zx-zf568", "pdfUrl": null, "abstract": "This is re-posted from my newsletter, where I'll be posting from now on: https://blog.stephenturner.us/p/biorecap-r-package-for-summarizing-biorxiv-preprints-local-llm ---TL;DR I wrote an R package that summarizes recent bioRxiv preprints using a locally running LLM via Ollama+ollamar, and produces a summary HTML report from a parameterized RMarkdown template.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1101/673665", "doi": "10.1101/673665", "title": "The effect of bioRxiv preprints on citations and altmetrics", "publicationYear": 2019, "publicationDate": "2019-06-22", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Nicholas Fraser, Fakhri Momeni, Philipp Mayr, Isabella Peters", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 18, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/673665", "pdfUrl": null, "abstract": "1. Abstract A potential motivation for scientists to deposit their scientific work as preprints is to enhance its citation or social impact, an effect which has been empirically observed for preprints in physics, astronomy and mathematics deposited to arXiv. In this study we assessed the citation and altmetric advantage of bioRxiv, a preprint server for the biological sciences. We retrieved metadata of all bioRxiv preprints deposited between November 2013 and December 2017, and matched them to articles that were subsequently published in peer-reviewed journals. Citation data from Scopus and altmetric data from Altmetric.com were used to compare citation and online sharing behaviour of bioRxiv preprints, their related journal articles, and non-deposited articles published in the same journals. We found that bioRxiv-deposited journal articles received a sizeable citation and altmetric advantage over non-deposited articles. Regression analysis reveals that this advantage is not explained by multiple explanatory variables related to the article and its authorship. bioRxiv preprints themselves are being directly cited in journal articles, regardless of whether the preprint has been subsequently published in a journal. bioRxiv preprints are also shared widely on Twitter and in blogs, but remain relatively scarce in mainstream media and Wikipedia articles, in comparison to peer-reviewed journal articles.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1101/515643", "doi": "10.1101/515643", "title": "Tracking the popularity and outcomes of all bioRxiv preprints", "publicationYear": 2019, "publicationDate": "2019-01-13", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Richard J. Abdill, Ran Blekhman", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 71, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/515643", "pdfUrl": null, "abstract": "Abstract Researchers in the life sciences are posting work to preprint servers at an unprecedented and increasing rate, sharing papers online before (or instead of) publication in peer-reviewed journals. Though the increasing acceptance of preprints is driving policy changes for journals and funders, there is little information about their usage. Here, we collected and analyzed data on all 37,648 preprints uploaded to bioRxiv.org, the largest biology-focused preprint server, in its first five years. We find preprints are being downloaded more than ever before (1.1 million tallied in October 2018 alone) and that the rate of preprints being posted has increased to a recent high of 2,100 per month. We also find that two-thirds of preprints posted before 2017 were later published in peer-reviewed journals, and find a relationship between journal impact factor and preprint downloads. Lastly, we developed Rxivist.org, a web application providing multiple ways of interacting with preprint metadata.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1101/2021.03.04.433874", "doi": "10.1101/2021.03.04.433874", "title": "Linguistic Analysis of the bioRxiv Preprint Landscape", "publicationYear": 2021, "publicationDate": "2021-03-04", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "David N. Nicholson, Vincent Rubinetti, Dongbo Hu, Marvin Thielk, Lawrence E. Hunter, Casey S. Greene", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 79, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/2021.03.04.433874", "pdfUrl": null, "abstract": "Abstract Preprints allow researchers to make their findings available to the scientific community before they have undergone peer review. Studies on preprints within bioRxiv have been largely focused on article metadata and how often these preprints are downloaded, cited, published, and discussed online. A missing element that has yet to be examined is the language contained within the bioRxiv preprint repository. We sought to compare and contrast linguistic features within bioRxiv preprints to published biomedical text as a whole as this is an excellent opportunity to examine how peer review changes these documents. The most prevalent features that changed appear to be associated with typesetting and mentions of supplementary sections or additional files. In addition to text comparison, we created document embeddings derived from a preprint-trained word2vec model. We found that these embeddings are able to parse out different scientific approaches and concepts, link unannotated preprint-peer reviewed article pairs, and identify journals that publish linguistically similar papers to a given preprint. We also used these embeddings to examine factors associated with the time elapsed between the posting of a first preprint and the appearance of a peer reviewed publication. We found that preprints with more versions posted and more textual changes took longer to publish. Lastly, we constructed a web application ( https://greenelab.github.io/preprint-similarity-search/ ) that allows users to identify which journals and articles that are most linguistically similar to a bioRxiv or medRxiv preprint as well as observe where the preprint would be positioned within a published article landscape.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1101/2020.03.06.981589", "doi": "10.1101/2020.03.06.981589", "title": "Quantifying and contextualizing the impact of bioRxiv preprints through automated social media audience segmentation", "publicationYear": 2020, "publicationDate": "2020-03-10", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Jedidiah Carlson, Kelley Harris", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 70, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/2020.03.06.981589", "pdfUrl": null, "abstract": "Abstract Engagement with scientific manuscripts is frequently facilitated by Twitter and other social media platforms. As such, the demographics of a paper’s social media audience provide a wealth of information about how scholarly research is transmitted, consumed, and interpreted by online communities. By paying attention to public perceptions of their publications, scientists can learn whether their research is stimulating positive scholarly and public thought. They can also become aware of potentially negative patterns of interest from groups that misinterpret their work in harmful ways, either willfully or unintentionally, and devise strategies for altering their messaging to mitigate these impacts. In this study, we collected 331,696 Twitter posts referencing 1,800 highly tweeted bioRxiv preprints and leveraged topic modeling to infer the characteristics of various communities engaging with each preprint on Twitter. We agnostically learned the characteristics of these audience sectors from keywords each user’s followers provide in their Twitter biographies. We estimate that 96% of the preprints analyzed are dominated by academic audiences on Twitter, suggesting that social media attention does not always correspond to greater public exposure. We further demonstrate how our audience segmentation method can quantify the level of interest from non-specialist audience sectors such as mental health advocates, dog lovers, video game developers, vegans, bitcoin investors, conspiracy theorists, journalists, religious groups, and political constituencies. Surprisingly, we also found that 10% of the highly tweeted preprints analyzed have sizable (>5%) audience sectors that are associated with right-wing white nationalist communities. Although none of these preprints intentionally espouse any right-wing extremist messages, cases exist where extremist appropriation comprises more than 50% of the tweets referencing a given preprint. These results present unique opportunities for improving and contextualizing research evaluation as well as shedding light on the unavoidable challenges of scientific discourse afforded by social media.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1101/2020.04.25.060756", "doi": "10.1101/2020.04.25.060756", "title": "International authorship and collaboration across bioRxiv preprints", "publicationYear": 2020, "publicationDate": "2020-04-25", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Richard J. Abdill, Elizabeth M. Adamowicz, Ran Blekhman", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 60, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/2020.04.25.060756", "pdfUrl": null, "abstract": "Abstract As preprints become integrated into conventional avenues of scientific communication, it’s critical to understand who is included and who is not. However, little is known about which countries are participating or how they collaborate with each other. Here, we present an analysis of all 67,885 preprints posted on bioRxiv (through 2019) using the first comprehensive dataset of country-level preprint author affiliations. We find the plurality of preprints (39%) come from the United States, and that countries such as the U.S. and U.K. are overrepresented on bioRxiv relative to their overall scientific output, while countries including China, Russia, and Turkey show lower bioRxiv adoption. We describe a set of “contributor countries” including Uganda, Croatia and Thailand that appear almost exclusively as non-senior authors on international collaborations. Lastly, we find multiple journals that publish a disproportionate number of preprints from some countries, a dynamic that almost always benefits manuscripts from the U.S.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1101/2023.02.14.23285870", "doi": "10.1101/2023.02.14.23285870", "title": "Indian COVID-19 Preprints Submissions in bioRxiv and medRxiv Preprint Servers", "publicationYear": 2023, "publicationDate": "2023-02-16", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Narayanaswamy Vasantha Raju, Murtala Ismail Adakawa, N.S. Harinarayana, Chandrappa", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/2023.02.14.23285870", "pdfUrl": null, "abstract": "ABSTRACT This research aimed at determining the growth of deposition of preprints on servers by Indian researchers during COVID-19 pandemic. In the pre-pandemic period, the dominant server was arXiv upon which research from physics and other related domains have been the most predominant depositors. When the pandemic erupted and the need to share research findings became imperative, many previously dormant preprint servers received vibrant activations from several scientists across the globe. This is with the intention of bridging the gap between delays inherent in reviewing process and the dire need to share information for finding everlasting solutions to the raging pandemic. Many researchers, institutions, countries, etc. have contributed in this regard. The study used quantitative method and iSearch Portfolio expert-curated source for publications and preprints related to either COVID-19 or the novel coronavirus SARS-CoV-2 developed and maintained by National Institute of Health (NIH), US iSearch COVID-19 Portfolio. The study examined the Indian COVID-19 preprints deposited in bioRxiv and medRxiv preprint servers. The findings indicated that, Indian researchers have posted their papers in large numbers in bioRxiv and medRxiv servers with the medRxiv having the highest preprints (417, 40.44%) in 2020 against its counterpart bioRxiv (118, 10.96%) in the same year. Similarly, infectious diseases (except HIV/AIDS) (311) had the highest recurrence of the preprints submitted for deposition in servers. This is followed by epidemiology (263), public and global health (122), bioinformatics (59), among others. There is high collaboration among researchers who deposited their preprints in these servers where about 257 (24.93%) preprints were co-authored by 11+ authors followed by 3-authored and 4-authored with 124 preprints respectively (together accounts for 24.06%) and 2-authroed (114 (11.04%) preprints) respectively in a diminishing manner. The study concluded that, Indian researchers are actively participating in depositing preprints in servers notably bioRxiv and medRxiv.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.22541/au.156173836.60281638", "doi": "10.22541/au.156173836.60281638", "title": "PREreview of bioRxiv article \"NRG1-mediated recognition of HopQ1 reveals a link between PAMP and Effector-triggered Immunity\"", "publicationYear": 2019, "publicationDate": "2019-06-28", "type": "posted-content", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Sophien Kamoun", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22541/au.156173836.60281638", "pdfUrl": null, "abstract": "This is a review of Brendolise et al. bioRxiv 293050; doi: https://doi.org/10.1101/293050 posted on April 1, 2018. This paper adds to a current body of research detailing the resistance mechanism triggered by the Pseudomonas syringe pv. tomato effector HopQ1 in the model plant Nicotiana benthamiana . This plant can be used as a source of novel disease resistance genes against plant pathogens.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.22541/au.157928045.50414963", "doi": "10.22541/au.157928045.50414963", "title": "Pre-print journal club review of BioRxiv article: Discovery of a prevalent picornavirus by visualizing zebrafish immune responses", "publicationYear": 2020, "publicationDate": "2020-01-17", "type": "posted-content", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Craig McCormick", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22541/au.157928045.50414963", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1101/2021.09.07.459259", "doi": "10.1101/2021.09.07.459259", "title": "Motivations, concerns and selection biases when posting preprints: a survey of bioRxiv authors", "publicationYear": 2021, "publicationDate": "2021-09-07", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Nicholas Fraser, Philipp Mayr, Isabella Peters", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 37, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/2021.09.07.459259", "pdfUrl": null, "abstract": "Abstract Since 2013, the usage of preprints as a means of sharing research in biology has rapidly grown, in particular via the preprint server bioRxiv. Recent studies have found that journal articles that were previously posted to bioRxiv received a higher number of citations or mentions/shares on other online platforms compared to articles in the same journals that were not posted. However, the exact causal mechanism for this effect has not been established, and may in part be related to authors’ biases in the selection of articles that are chosen to be posted as preprints. We aimed to investigate this mechanism by conducting a mixed-methods survey of 1,444 authors of bioRxiv preprints, to investigate the reasons that they post or do not post certain articles as preprints, and to make comparisons between articles they choose to post and not post as preprints. We find that authors are most strongly motivated to post preprints to increase awareness of their work and increase the speed of its dissemination; conversely, the strongest reasons for not posting preprints centre around a lack of awareness of preprints and reluctance to publicly post work that has not undergone a peer review process. We additionally find weak evidence that authors preferentially select their highest quality, most novel or most significant research to post as preprints, however, authors retain an expectation that articles they post as preprints will receive more citations or be shared more widely online than articles not posted.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.31219/osf.io/wr6d9", "doi": "10.31219/osf.io/wr6d9", "title": "Một bản thảo về virus corona trên bioRxiv bị rút: Khoảnh khắc quan trọng đối với xuất bản học thuật", "publicationYear": 2022, "publicationDate": "2022-06-01", "type": "posted-content", "publisher": "Center for Open Science", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Sri Ants", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.31219/osf.io/wr6d9", "pdfUrl": null, "abstract": "SSHPA (05-02-2020; Nguyễn Thị Linh) — Bài viết này tóm lược thảo luận quan trọng của hai tác giả Ivan Oransky và Adam Marcus về câu chuyện một bản thảo trên bioRxiv bị rút bỏ và ý nghĩa của nó với xuất bản học thuật hiện nay (nguồn ghi ở mục Tham khảo, dẫn chiếu Retraction Watch và STAT News).", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.22541/au.158567360.08742076", "doi": "10.22541/au.158567360.08742076", "title": "PREreview of bioRxiv article “Ptr1 evolved convergently with RPS2 and Mr5 to mediate recognition of AvrRpt2 in diverse solanaceous species\"", "publicationYear": 2020, "publicationDate": "2020-03-31", "type": "posted-content", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Matthew Helm, Morgan E. Carter", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22541/au.158567360.08742076", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1101/2023.10.31.565037", "doi": "10.1101/2023.10.31.565037", "title": "VLIB: Unveiling insights through Visual and Linguistic Integration of Biorxiv data relevant to cancer via Multimodal Large Language Model", "publicationYear": 2023, "publicationDate": "2023-11-03", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Vignesh Prabhakar, Kai Liu", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/2023.10.31.565037", "pdfUrl": null, "abstract": "Abstract The field of cancer research has greatly benefited from the wealth of new knowledge provided by research articles and preprints on platforms like Biorxiv. This study investigates the role of scientific figures and their accompanying captions in enhancing our comprehension of cancer. Leveraging the capabilities of Multimodal Large Language Models (MLLMs), we conduct a comprehensive analysis of both visual and linguistic data in biomedical literature. Our work introduces VLIB, a substantial scientific figure-caption dataset generated from cancer biology papers on Biorxiv. After thorough preprocessing, which includes figure-caption pair extraction, sub-figure identification, and text normalization, VLIB comprises over 500,000 figures from more than 70,000 papers, each accompanied by relevant captions. We fine-tune baseline MLLMs using our VLIB dataset for downstream vision-language tasks, such as image captioning and visual question answering (VQA), to assess their performance. Our experimental results underscore the vital role played by scientific figures, including molecular structures, histological images, and data visualizations, in conjunction with their captions, in facilitating knowledge translation through MLLMs. Specifically, we achieved a ROUGE score of 0.66 for VQA and 0.68 for image captioning, as well as a BLEU score of 0.72 for VQA and 0.70 for image captioning. Furthermore, our investigation highlights the potential of MLLMs to bridge the gap between artificial intelligence and domain experts in the field of cancer biology.", "subject": null, "language": null, "_run_id": "ZI3Oirsf5ESNRmwgf", "_dataset_id": "Gd7LJBsgdWbGUR6mv"}
{"paperId": "10.1093/nar/gkh340", "doi": "10.1093/nar/gkh340", "title": "MUSCLE: multiple sequence alignment with high accuracy and high throughput", "publicationYear": 2004, "publicationDate": "2004-03-08", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Nucleic Acids Research", "volume": "32", "issue": "5", "page": "1792-1797", "issn": "1362-4962", "isbn": null, "authors": "R. C. Edgar", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 38137, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/nar/gkh340", "pdfUrl": "http://academic.oup.com/nar/article-pdf/32/5/1792/7055030/gkh340.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1038/nmeth.3869", "doi": "10.1038/nmeth.3869", "title": "DADA2: High-resolution sample inference from Illumina amplicon data", "publicationYear": 2016, "publicationDate": "2016-07", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Methods", "volume": "13", "issue": "7", "page": "581-583", "issn": "1548-7091, 1548-7105", "isbn": null, "authors": "Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P Holmes", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 32805, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nmeth.3869", "pdfUrl": "http://www.nature.com/articles/nmeth.3869.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1038/nmeth.f.303", "doi": "10.1038/nmeth.f.303", "title": "QIIME allows analysis of high-throughput community sequencing data", "publicationYear": 2010, "publicationDate": "2010-05", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Methods", "volume": "7", "issue": "5", "page": "335-336", "issn": "1548-7091, 1548-7105", "isbn": null, "authors": "J Gregory Caporaso, Justin Kuczynski, Jesse Stombaugh, Kyle Bittinger, Frederic D Bushman, Elizabeth K Costello, Noah Fierer, Antonio Gonzalez Peña, Julia K Goodrich, Jeffrey I Gordon, Gavin A Huttley, Scott T Kelley, Dan Knights, Jeremy E Koenig, Ruth E Ley, Catherine A Lozupone, Daniel McDonald, Brian D Muegge, Meg Pirrung, Jens Reeder, Joel R Sevinsky, Peter J Turnbaugh, William A Walters, Jeremy Widmann, Tanya Yatsunenko, Jesse Zaneveld, Rob Knight", "authorCount": 27, "firstAuthorAffiliation": null, "isReferencedByCount": 30937, "referenceCount": 6, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nmeth.f.303", "pdfUrl": "http://www.nature.com/articles/nmeth.f.303.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.14806/ej.17.1.200", "doi": "10.14806/ej.17.1.200", "title": "Cutadapt removes adapter sequences from high-throughput sequencing reads", "publicationYear": 2011, "publicationDate": "2011-05-02", "type": "journal-article", "publisher": "EMBnet Stichting", "containerTitle": "EMBnet.journal", "volume": "17", "issue": "1", "page": "10", "issn": "2226-6089", "isbn": null, "authors": "Marcel Martin", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 30548, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.14806/ej.17.1.200", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1038/353737a0", "doi": "10.1038/353737a0", "title": "A low-cost, high-efficiency solar cell based on dye-sensitized colloidal TiO2 films", "publicationYear": 1991, "publicationDate": "1991-10", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "353", "issue": "6346", "page": "737-740", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Brian O'Regan, Michael Grätzel", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 26519, "referenceCount": 19, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/353737a0", "pdfUrl": "http://www.nature.com/articles/353737a0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1016/j.softx.2015.06.001", "doi": "10.1016/j.softx.2015.06.001", "title": "GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers", "publicationYear": 2015, "publicationDate": "2015-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "SoftwareX", "volume": "1-2", "issue": null, "page": "19-25", "issn": "2352-7110", "isbn": null, "authors": "Mark James Abraham, Teemu Murtola, Roland Schulz, Szilárd Páll, Jeremy C. Smith, Berk Hess, Erik Lindahl", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 25268, "referenceCount": 47, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "European Research Council, Swedish Research Council, ScalaLife EU infrastructure", "funderIds": "10.13039/501100000781, 10.13039/501100004359", "url": "https://doi.org/10.1016/j.softx.2015.06.001", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1001/jama.285.19.2486", "doi": "10.1001/jama.285.19.2486", "title": "Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)", "publicationYear": 2001, "publicationDate": "2001-05-16", "type": "journal-article", "publisher": "American Medical Association (AMA)", "containerTitle": "JAMA: The Journal of the American Medical Association", "volume": "285", "issue": "19", "page": "2486-2497", "issn": "0098-7484, 1538-3598", "isbn": null, "authors": "Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 23253, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1001/jama.285.19.2486", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1093/bioinformatics/btu638", "doi": "10.1093/bioinformatics/btu638", "title": "HTSeq—a Python framework to work with high-throughput sequencing data", "publicationYear": 2015, "publicationDate": "2015-01-15", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Bioinformatics", "volume": "31", "issue": "2", "page": "166-169", "issn": "1367-4811, 1367-4803", "isbn": null, "authors": "Simon Anders, Paul Theodor Pyl, Wolfgang Huber", "authorCount": 3, "firstAuthorAffiliation": "Genome Biology Unit, European Molecular Biology Laboratory, 69111 Heidelberg, Germany", "isReferencedByCount": 19533, "referenceCount": 14, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/bioinformatics/btu638", "pdfUrl": "https://academic.oup.com/bioinformatics/article-pdf/31/2/166/49011133/bioinformatics_31_2_166.pdf", "abstract": "Abstract Motivation: A large choice of tools exists for many standard tasks in the analysis of high-throughput sequencing (HTS) data. However, once a project deviates from standard workflows, custom scripts are needed. Results: We present HTSeq, a Python library to facilitate the rapid development of such scripts. HTSeq offers parsers for many common data formats in HTS projects, as well as classes to represent data, such as genomic coordinates, sequences, sequencing reads, alignments, gene model information and variant calls, and provides data structures that allow for querying via genomic coordinates. We also present htseq-count, a tool developed with HTSeq that preprocesses RNA-Seq data for differential expression analysis by counting the overlap of reads with genes. Availability and implementation: HTSeq is released as an open-source software under the GNU General Public Licence and available from http://www-huber.embl.de/HTSeq or from the Python Package Index at https://pypi.python.org/pypi/HTSeq . Contact: sanders@fs.tum.de", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1083/jcb.17.1.208", "doi": "10.1083/jcb.17.1.208", "title": "THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY", "publicationYear": 1963, "publicationDate": "1963-04-01", "type": "journal-article", "publisher": "Rockefeller University Press", "containerTitle": "The Journal of Cell Biology", "volume": "17", "issue": "1", "page": "208-212", "issn": "1540-8140, 0021-9525", "isbn": null, "authors": "Edward S. Reynolds", "authorCount": 1, "firstAuthorAffiliation": "From the Department of Anatomy, Harvard Medical School, Boston", "isReferencedByCount": 18991, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1083/jcb.17.1.208", "pdfUrl": "https://rupress.org/jcb/article-pdf/17/1/208/1534055/208.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1063/1.447334", "doi": "10.1063/1.447334", "title": "A unified formulation of the constant temperature molecular dynamics methods", "publicationYear": 1984, "publicationDate": "1984-07-01", "type": "journal-article", "publisher": "AIP Publishing", "containerTitle": "The Journal of Chemical Physics", "volume": "81", "issue": "1", "page": "511-519", "issn": "0021-9606, 1089-7690", "isbn": null, "authors": "Shuichi Nosé", "authorCount": 1, "firstAuthorAffiliation": "Division of Chemistry, National Research Council of Canada, Ottawa, Ontario, Canada, K1A OR6", "isReferencedByCount": 17988, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1063/1.447334", "pdfUrl": "https://pubs.aip.org/aip/jcp/article-pdf/81/1/511/18949062/511_1_online.pdf", "abstract": "Three recently proposed constant temperature molecular dynamics methods by: (i) Nosé (Mol. Phys., to be published); (ii) Hoover et al. [Phys. Rev. Lett. 48, 1818 (1982)], and Evans and Morriss [Chem. Phys. 77, 63 (1983)]; and (iii) Haile and Gupta [J. Chem. Phys. 79, 3067 (1983)] are examined analytically via calculating the equilibrium distribution functions and comparing them with that of the canonical ensemble. Except for effects due to momentum and angular momentum conservation, method (1) yields the rigorous canonical distribution in both momentum and coordinate space. Method (2) can be made rigorous in coordinate space, and can be derived from method (1) by imposing a specific constraint. Method (3) is not rigorous and gives a deviation of order N−1/2 from the canonical distribution (N the number of particles). The results for the constant temperature–constant pressure ensemble are similar to the canonical ensemble case.", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1002/joc.1276", "doi": "10.1002/joc.1276", "title": "Very high resolution interpolated climate surfaces for global land areas", "publicationYear": 2005, "publicationDate": "2005-12", "type": "journal-article", "publisher": "Wiley", "containerTitle": "International Journal of Climatology", "volume": "25", "issue": "15", "page": "1965-1978", "issn": "0899-8418, 1097-0088", "isbn": null, "authors": "Robert J. Hijmans, Susan E. Cameron, Juan L. Parra, Peter G. Jones, Andy Jarvis", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 16639, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/joc.1276", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1086/307221", "doi": "10.1086/307221", "title": "Measurements of Ω and Λ from 42 High‐Redshift Supernovae", "publicationYear": 1999, "publicationDate": "1999-06", "type": "journal-article", "publisher": "American Astronomical Society", "containerTitle": "The Astrophysical Journal", "volume": "517", "issue": "2", "page": "565-586", "issn": "0004-637X, 1538-4357", "isbn": null, "authors": "S. Perlmutter, G. Aldering, G. Goldhaber, R. A. Knop, P. Nugent, P. G. Castro, S. Deustua, S. Fabbro, A. Goobar, D. E. Groom, I. M. Hook, A. G. Kim, M. Y. Kim, J. C. Lee, N. J. Nunes, R. Pain, C. R. Pennypacker, R. Quimby, C. Lidman, R. S. Ellis, M. Irwin, R. G. McMahon, P. Ruiz‐Lapuente, N. Walton, B. Schaefer, B. J. Boyle, A. V. Filippenko, T. Matheson, A. S. Fruchter, N. Panagia, H. J. M. Newberg, W. J. Couch, The Supernova Cosmology Project", "authorCount": 33, "firstAuthorAffiliation": null, "isReferencedByCount": 15585, "referenceCount": 106, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1086/307221", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1109/cvpr52688.2022.01042", "doi": "10.1109/cvpr52688.2022.01042", "title": "High-Resolution Image Synthesis with Latent Diffusion Models", "publicationYear": 2022, "publicationDate": "2022-06", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR)", "volume": null, "issue": null, "page": "10674-10685", "issn": null, "isbn": null, "authors": "Robin Rombach, Andreas Blattmann, Dominik Lorenz, Patrick Esser, Bjorn Ommer", "authorCount": 5, "firstAuthorAffiliation": "Ludwig Maximilian University of Munich & IWR, Heidelberg University,Germany", "isReferencedByCount": 15107, "referenceCount": 105, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": "German Research Foundation", "funderIds": "10.13039/100004807", "url": "https://doi.org/10.1109/cvpr52688.2022.01042", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1001/jama.289.19.2560", "doi": "10.1001/jama.289.19.2560", "title": "The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>", "publicationYear": 2003, "publicationDate": "2003-05-21", "type": "journal-article", "publisher": "American Medical Association (AMA)", "containerTitle": "JAMA", "volume": "289", "issue": "19", "page": "2560", "issn": "0098-7484", "isbn": null, "authors": "Aram V. Chobanian", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 14642, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1001/jama.289.19.2560", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1038/nbt.1511", "doi": "10.1038/nbt.1511", "title": "MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification", "publicationYear": 2008, "publicationDate": "2008-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Biotechnology", "volume": "26", "issue": "12", "page": "1367-1372", "issn": "1087-0156, 1546-1696", "isbn": null, "authors": "Jürgen Cox, Matthias Mann", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 14587, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nbt.1511", "pdfUrl": "http://www.nature.com/articles/nbt.1511.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1016/s0021-9258(19)41496-8", "doi": "10.1016/s0021-9258(19)41496-8", "title": "High resolution two-dimensional electrophoresis of proteins.", "publicationYear": 1975, "publicationDate": "1975-05", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Biological Chemistry", "volume": "250", "issue": "10", "page": "4007-4021", "issn": "0021-9258", "isbn": null, "authors": "PH O'Farrell", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 14539, "referenceCount": 36, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0021-9258(19)41496-8", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1002/adem.200300567", "doi": "10.1002/adem.200300567", "title": "Nanostructured High‐Entropy Alloys with Multiple Principal Elements: Novel Alloy Design Concepts and Outcomes", "publicationYear": 2004, "publicationDate": "2004-05", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Engineering Materials", "volume": "6", "issue": "5", "page": "299-303", "issn": "1438-1656, 1527-2648", "isbn": null, "authors": "J.‐W. Yeh, S.‐K. Chen, S.‐J. Lin, J.‐Y. Gan, T.‐S. Chin, T.‐T. Shun, C.‐H. Tsau, S.‐Y. Chang", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 14514, "referenceCount": 26, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/adem.200300567", "pdfUrl": null, "abstract": "A new approach for the design of alloys is presented in this study. These “high‐entropy alloys” with multi‐principal elements were synthesized using well‐developed processing technologies. Preliminary results demonstrate examples of the alloys with simple crystal structures, nanostructures, and promising mechanical properties. This approach may be opening a new era in materials science and engineering.", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1038/msb.2011.75", "doi": "10.1038/msb.2011.75", "title": "Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega", "publicationYear": 2011, "publicationDate": "2011-10-11", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Molecular Systems Biology", "volume": "7", "issue": "1", "page": null, "issn": "1744-4292", "isbn": null, "authors": "Fabian Sievers, Andreas Wilm, David Dineen, Toby J Gibson, Kevin Karplus, Weizhong Li, Rodrigo Lopez, Hamish McWilliam, Michael Remmert, Johannes Söding, Julie D Thompson, Desmond G Higgins", "authorCount": 12, "firstAuthorAffiliation": null, "isReferencedByCount": 14484, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-sa/3.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/msb.2011.75", "pdfUrl": "https://link.springer.com/content/pdf/10.1038/msb.2011.75.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1016/0003-2697(83)90418-9", "doi": "10.1016/0003-2697(83)90418-9", "title": "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity", "publicationYear": 1983, "publicationDate": "1983-07", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Analytical Biochemistry", "volume": "132", "issue": "1", "page": "6-13", "issn": "0003-2697", "isbn": null, "authors": "Andrew P. Feinberg, Bert Vogelstein", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 14332, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/0003-2697(83)90418-9", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1007/bf00656997", "doi": "10.1007/bf00656997", "title": "Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches", "publicationYear": 1981, "publicationDate": "1981-08", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Pflügers Archiv - European Journal of Physiology", "volume": "391", "issue": "2", "page": "85-100", "issn": "0031-6768, 1432-2013", "isbn": null, "authors": "O. P. Hamill, A. Marty, E. Neher, B. Sakmann, F. J. Sigworth", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 13509, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/bf00656997", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/BF00656997.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1093/nar/gkq603", "doi": "10.1093/nar/gkq603", "title": "ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data", "publicationYear": 2010, "publicationDate": "2010-09-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Nucleic Acids Research", "volume": "38", "issue": "16", "page": "e164-e164", "issn": "0305-1048, 1362-4962", "isbn": null, "authors": "K. Wang, M. Li, H. Hakonarson", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 13303, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/2.5", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/nar/gkq603", "pdfUrl": "http://academic.oup.com/nar/article-pdf/38/16/e164/7701417/gkq603.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1007/bf01303701", "doi": "10.1007/bf01303701", "title": "Possible highT c superconductivity in the Ba?La?Cu?O system", "publicationYear": 1986, "publicationDate": "1986-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Zeitschrift f�r Physik B Condensed Matter", "volume": "64", "issue": "2", "page": "189-193", "issn": "0722-3277, 1434-6036", "isbn": null, "authors": "J. G. Bednorz, K. A. M�ller", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 12930, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/bf01303701", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/BF01303701.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1161/circ.106.25.3143", "doi": "10.1161/circ.106.25.3143", "title": "Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report", "publicationYear": 2002, "publicationDate": "2002-12-17", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "106", "issue": "25", "page": "3143-3143", "issn": "0009-7322, 1524-4539", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 11991, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circ.106.25.3143", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1021/cr980032t", "doi": "10.1021/cr980032t", "title": "Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis", "publicationYear": 1999, "publicationDate": "1999-08-11", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Chemical Reviews", "volume": "99", "issue": "8", "page": "2071-2084", "issn": "0009-2665, 1520-6890", "isbn": null, "authors": "Thomas Welton", "authorCount": 1, "firstAuthorAffiliation": "Department of Chemistry, Imperial College of Science Technology and Medicine, South Kensington, London SW7 2AY, U.K.", "isReferencedByCount": 11542, "referenceCount": 147, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/cr980032t", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1103/physrev.108.1175", "doi": "10.1103/physrev.108.1175", "title": "Theory of Superconductivity", "publicationYear": 1957, "publicationDate": "1957-12-01", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Physical Review", "volume": "108", "issue": "5", "page": "1175-1204", "issn": "0031-899X", "isbn": null, "authors": "J. Bardeen, L. N. Cooper, J. R. Schrieffer", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 11070, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "http://link.aps.org/licenses/aps-default-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1103/physrev.108.1175", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1126/science.1171245", "doi": "10.1126/science.1171245", "title": "Large-Area Synthesis of High-Quality and Uniform Graphene Films on Copper Foils", "publicationYear": 2009, "publicationDate": "2009-06-05", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "324", "issue": "5932", "page": "1312-1314", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "Xuesong Li, Weiwei Cai, Jinho An, Seyoung Kim, Junghyo Nah, Dongxing Yang, Richard Piner, Aruna Velamakanni, Inhwa Jung, Emanuel Tutuc, Sanjay K. Banerjee, Luigi Colombo, Rodney S. Ruoff", "authorCount": 13, "firstAuthorAffiliation": "Department of Mechanical Engineering and the Texas Materials Institute, 1 University Station C2200, The University of Texas at Austin, Austin, TX 78712–0292, USA.", "isReferencedByCount": 10397, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.1171245", "pdfUrl": null, "abstract": "Growing Graphene The highest quality graphene samples, single-atom-thick layers of carbon, are suspended flakes exfoliated from graphite, but these samples are very small in size (square micrometers). For many electronics applications, larger areas are needed. Li et al. (p. 1312 , published online 7 May) show that graphene grows in a self-limiting way on copper films as large-area sheets (one square centimeter) from methane through a chemical vapor deposition process. The films, which are mainly one layer in thickness, can be transferred to other substrates and have electron mobilities as high as 4300 square centimeters per volt second.", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1161/01.hyp.0000107251.49515.c2", "doi": "10.1161/01.hyp.0000107251.49515.c2", "title": "Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure", "publicationYear": 2003, "publicationDate": "2003-12", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Hypertension", "volume": "42", "issue": "6", "page": "1206-1252", "issn": "0194-911X, 1524-4563", "isbn": null, "authors": "Aram V. Chobanian, George L. Bakris, Henry R. Black, William C. Cushman, Lee A. Green, Joseph L. Izzo, Daniel W. Jones, Barry J. Materson, Suzanne Oparil, Jackson T. Wright, Edward J. Roccella, the National High Blood Pressure Education Program Coordinating Committee", "authorCount": 12, "firstAuthorAffiliation": "From Boston University School of Medicine (A.V.C.), Boston, Mass; Rush University Medical Center (G.L.B., H.R.B.), Chicago, Ill; Veterans Affairs Medical Center (W.C.C.), Memphis, Tenn; University of Michigan (L.A.G.), Ann Arbor, Mich; State University of New York at Buffalo School of Medicine (J.L.I. Jr.), Buffalo, NY; University of Mississippi Medical Center (D.W.J.), Jackson, Miss; University of Miami (B.J.M.), Miami, Fla; University of Alabama at Birmingham (S.O.), Birmingham, Ala; Case Western...", "isReferencedByCount": 10087, "referenceCount": 386, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/01.hyp.0000107251.49515.c2", "pdfUrl": null, "abstract": "The National High Blood Pressure Education Program presents the complete Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Like its predecessors, the purpose is to provide an evidence-based approach to the prevention and management of hypertension. The key messages of this report are these: in those older than age 50, systolic blood pressure (BP) of greater than 140 mm Hg is a more important cardiovascular disease (CVD) risk factor than diastolic BP; beginning at 115/75 mm Hg, CVD risk doubles for each increment of 20/10 mm Hg; those who are normotensive at 55 years of age will have a 90% lifetime risk of developing hypertension; prehypertensive individuals (systolic BP 120–139 mm Hg or diastolic BP 80–89 mm Hg) require health-promoting lifestyle modifications to prevent the progressive rise in blood pressure and CVD; for uncomplicated hypertension, thiazide diuretic should be used in drug treatment for most, either alone or combined with drugs from other classes; this report delineates specific high-risk conditions that are compelling indications for the use of other antihypertensive drug classes (angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, beta-blockers, calcium channel blockers); two or more antihypertensive medications will be required to achieve goal BP (<140/90 mm Hg, or <130/80 mm Hg) for patients with diabetes and chronic kidney disease; for patients whose BP is more than 20 mm Hg above the systolic BP goal or more than 10 mm Hg above the diastolic BP goal, initiation of therapy using two agents, one of which usually will be a thiazide diuretic, should be considered; regardless of therapy or care, hypertension will be controlled only if patients are motivated to stay on their treatment plan. Positive experiences, trust in the clinician, and empathy improve patient motivation and satisfaction. This report serves as a guide, and the committee continues to recognize that the responsible physician’s judgment remains paramount.", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1126/science.1244693", "doi": "10.1126/science.1244693", "title": "High-Resolution Global Maps of 21st-Century Forest Cover Change", "publicationYear": 2013, "publicationDate": "2013-11-15", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "342", "issue": "6160", "page": "850-853", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "M. C. Hansen, P. V. Potapov, R. Moore, M. Hancher, S. A. Turubanova, A. Tyukavina, D. Thau, S. V. Stehman, S. J. Goetz, T. R. Loveland, A. Kommareddy, A. Egorov, L. Chini, C. O. Justice, J. R. G. Townshend", "authorCount": 15, "firstAuthorAffiliation": "Department of Geographical Sciences, University of Maryland, College Park, MD 20742, USA.", "isReferencedByCount": 9623, "referenceCount": 40, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.1244693", "pdfUrl": null, "abstract": "Forests in Flux Forests worldwide are in a state of flux, with accelerating losses in some regions and gains in others. Hansen et al. (p. 850 ) examined global Landsat data at a 30-meter spatial resolution to characterize forest extent, loss, and gain from 2000 to 2012. Globally, 2.3 million square kilometers of forest were lost during the 12-year study period and 0.8 million square kilometers of new forest were gained. The tropics exhibited both the greatest losses and the greatest gains (through regrowth and plantation), with losses outstripping gains.", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1093/nar/8.19.4321", "doi": "10.1093/nar/8.19.4321", "title": "Rapid isolation of high molecular weight plant DNA", "publicationYear": 1980, "publicationDate": "1980", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Nucleic Acids Research", "volume": "8", "issue": "19", "page": "4321-4326", "issn": "0305-1048, 1362-4962", "isbn": null, "authors": "M.G. Murray, W.F. Thompson", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 9610, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/nar/8.19.4321", "pdfUrl": "http://academic.oup.com/nar/article-pdf/8/19/4321/7056145/8-19-4321.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1038/nature12340", "doi": "10.1038/nature12340", "title": "Sequential deposition as a route to high-performance perovskite-sensitized solar cells", "publicationYear": 2013, "publicationDate": "2013-07", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "499", "issue": "7458", "page": "316-319", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Julian Burschka, Norman Pellet, Soo-Jin Moon, Robin Humphry-Baker, Peng Gao, Mohammad K. Nazeeruddin, Michael Grätzel", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 9144, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nature12340", "pdfUrl": "http://www.nature.com/articles/nature12340.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1038/nmat3191", "doi": "10.1038/nmat3191", "title": "Li–O2 and Li–S batteries with high energy storage", "publicationYear": 2012, "publicationDate": "2012-01", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Materials", "volume": "11", "issue": "1", "page": "19-29", "issn": "1476-1122, 1476-4660", "isbn": null, "authors": "Peter G. Bruce, Stefan A. Freunberger, Laurence J. Hardwick, Jean-Marie Tarascon", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 9118, "referenceCount": 137, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nmat3191", "pdfUrl": "https://www.nature.com/articles/nmat3191.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1029/2002jd002670", "doi": "10.1029/2002jd002670", "title": "Global analyses of sea surface temperature, sea ice, and night marine air temperature since the late nineteenth century", "publicationYear": 2003, "publicationDate": "2003-07-27", "type": "journal-article", "publisher": "American Geophysical Union (AGU)", "containerTitle": "Journal of Geophysical Research: Atmospheres", "volume": "108", "issue": "D14", "page": null, "issn": "0148-0227", "isbn": null, "authors": "N. A. Rayner, D. E. Parker, E. B. Horton, C. K. Folland, L. V. Alexander, D. P. Rowell, E. C. Kent, A. Kaplan", "authorCount": 8, "firstAuthorAffiliation": "Hadley Centre for Climate Prediction and Research Met Office  Bracknell UK", "isReferencedByCount": 9100, "referenceCount": 84, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1029/2002jd002670", "pdfUrl": null, "abstract": "We present the Met Office Hadley Centre's sea ice and sea surface temperature (SST) data set, HadISST1, and the nighttime marine air temperature (NMAT) data set, HadMAT1. HadISST1 replaces the global sea ice and sea surface temperature (GISST) data sets and is a unique combination of monthly globally complete fields of SST and sea ice concentration on a 1° latitude‐longitude grid from 1871. The companion HadMAT1 runs monthly from 1856 on a 5° latitude‐longitude grid and incorporates new corrections for the effect on NMAT of increasing deck (and hence measurement) heights. HadISST1 and HadMAT1 temperatures are reconstructed using a two‐stage reduced‐space optimal interpolation procedure, followed by superposition of quality‐improved gridded observations onto the reconstructions to restore local detail. The sea ice fields are made more homogeneous by compensating satellite microwave‐based sea ice concentrations for the impact of surface melt effects on retrievals in the Arctic and for algorithm deficiencies in the Antarctic and by making the historical in situ concentrations consistent with the satellite data. SSTs near sea ice are estimated using statistical relationships between SST and sea ice concentration. HadISST1 compares well with other published analyses, capturing trends in global, hemispheric, and regional SST well, containing SST fields with more uniform variance through time and better month‐to‐month persistence than those in GISST. HadMAT1 is more consistent with SST and with collocated land surface air temperatures than previous NMAT data sets.", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1093/biostatistics/4.2.249", "doi": "10.1093/biostatistics/4.2.249", "title": "Exploration, normalization, and summaries of high density oligonucleotide array probe level data", "publicationYear": 2003, "publicationDate": "2003-04-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Biostatistics", "volume": "4", "issue": "2", "page": "249-264", "issn": "1465-4644, 1468-4357", "isbn": null, "authors": "R. A. Irizarry", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 8667, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/biostatistics/4.2.249", "pdfUrl": "http://academic.oup.com/biostatistics/article-pdf/4/2/249/677018/040249.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1016/j.actamat.2016.08.081", "doi": "10.1016/j.actamat.2016.08.081", "title": "A critical review of high entropy alloys and related concepts", "publicationYear": 2017, "publicationDate": "2017-01", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Acta Materialia", "volume": "122", "issue": null, "page": "448-511", "issn": "1359-6454", "isbn": null, "authors": "D.B. Miracle, O.N. Senkov", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 8610, "referenceCount": 352, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Air Force", "funderIds": null, "url": "https://doi.org/10.1016/j.actamat.2016.08.081", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1038/s41591-018-0300-7", "doi": "10.1038/s41591-018-0300-7", "title": "High-performance medicine: the convergence of human and artificial intelligence", "publicationYear": 2019, "publicationDate": "2019-01", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Medicine", "volume": "25", "issue": "1", "page": "44-56", "issn": "1078-8956, 1546-170X", "isbn": null, "authors": "Eric J. Topol", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 8441, "referenceCount": 216, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/s41591-018-0300-7", "pdfUrl": "http://www.nature.com/articles/s41591-018-0300-7.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1126/science.1060367", "doi": "10.1126/science.1060367", "title": "Room-Temperature Ultraviolet Nanowire Nanolasers", "publicationYear": 2001, "publicationDate": "2001-06-08", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "292", "issue": "5523", "page": "1897-1899", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "Michael H. Huang, Samuel Mao, Henning Feick, Haoquan Yan, Yiying Wu, Hannes Kind, Eicke Weber, Richard Russo, Peidong Yang", "authorCount": 9, "firstAuthorAffiliation": "Department of Chemistry, University of California,", "isReferencedByCount": 8388, "referenceCount": 19, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.1060367", "pdfUrl": null, "abstract": "Room-temperature ultraviolet lasing in semiconductor nanowire arrays has been demonstrated. The self-organized, <0001> oriented zinc oxide nanowires grown on sapphire substrates were synthesized with a simple vapor transport and condensation process. These wide band-gap semiconductor nanowires form natural laser cavities with diameters varying from 20 to 150 nanometers and lengths up to 10 micrometers. Under optical excitation, surface-emitting lasing action was observed at 385 nanometers, with an emission linewidth less than 0.3 nanometer. The chemical flexibility and the one-dimensionality of the nanowires make them ideal miniaturized laser light sources. These short-wavelength nanolasers could have myriad applications, including optical computing, information storage, and microanalysis.", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1093/bib/bbs017", "doi": "10.1093/bib/bbs017", "title": "Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration", "publicationYear": 2013, "publicationDate": "2013-03-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Briefings in Bioinformatics", "volume": "14", "issue": "2", "page": "178-192", "issn": "1467-5463, 1477-4054", "isbn": null, "authors": "H. Thorvaldsdottir, J. T. Robinson, J. P. Mesirov", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 8354, "referenceCount": 17, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/bib/bbs017", "pdfUrl": "http://academic.oup.com/bib/article-pdf/14/2/178/546734/bbs017.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1038/s42256-019-0048-x", "doi": "10.1038/s42256-019-0048-x", "title": "Stop explaining black box machine learning models for high stakes decisions and use interpretable models instead", "publicationYear": 2019, "publicationDate": "2019-05-13", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Machine Intelligence", "volume": "1", "issue": "5", "page": "206-215", "issn": "2522-5839", "isbn": null, "authors": "Cynthia Rudin", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 8316, "referenceCount": 52, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/s42256-019-0048-x", "pdfUrl": "https://www.nature.com/articles/s42256-019-0048-x.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1038/ismej.2012.8", "doi": "10.1038/ismej.2012.8", "title": "Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms", "publicationYear": 2012, "publicationDate": "2012-08-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "The ISME Journal", "volume": "6", "issue": "8", "page": "1621-1624", "issn": "1751-7362, 1751-7370", "isbn": null, "authors": "J Gregory Caporaso, Christian L Lauber, William A Walters, Donna Berg-Lyons, James Huntley, Noah Fierer, Sarah M Owens, Jason Betley, Louise Fraser, Markus Bauer, Niall Gormley, Jack A Gilbert, Geoff Smith, Rob Knight", "authorCount": 14, "firstAuthorAffiliation": "Department of Computer Science, Northern Arizona University , Flagstaff, AZ , USA", "isReferencedByCount": 8047, "referenceCount": 9, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-sa/3.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/ismej.2012.8", "pdfUrl": "http://www.nature.com/articles/ismej20128.pdf", "abstract": "Abstract DNA sequencing continues to decrease in cost with the Illumina HiSeq2000 generating up to 600 Gb of paired-end 100 base reads in a ten-day run. Here we present a protocol for community amplicon sequencing on the HiSeq2000 and MiSeq Illumina platforms, and apply that protocol to sequence 24 microbial communities from host-associated and free-living environments. A critical question as more sequencing platforms become available is whether biological conclusions derived on one platform are consistent with what would be derived on a different platform. We show that the protocol developed for these instruments successfully recaptures known biological results, and additionally that biological conclusions are consistent across sequencing platforms (the HiSeq2000 versus the MiSeq) and across the sequenced regions of amplicons.", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1016/0022-2836(77)90052-3", "doi": "10.1016/0022-2836(77)90052-3", "title": "Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I", "publicationYear": 1977, "publicationDate": "1977-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Molecular Biology", "volume": "113", "issue": "1", "page": "237-251", "issn": "0022-2836", "isbn": null, "authors": "Peter W.J. Rigby, Marianne Dieckmann, Carl Rhodes, Paul Berg", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 7911, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "American Cancer Society, U.S. Public Health Service", "funderIds": "10.13039/100000048, 10.13039/100007197", "url": "https://doi.org/10.1016/0022-2836(77)90052-3", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1093/nar/gkab1061", "doi": "10.1093/nar/gkab1061", "title": "AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models", "publicationYear": 2022, "publicationDate": "2022-01-07", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Nucleic Acids Research", "volume": "50", "issue": "D1", "page": "D439-D444", "issn": "0305-1048, 1362-4962", "isbn": null, "authors": "Mihaly Varadi, Stephen Anyango, Mandar Deshpande, Sreenath Nair, Cindy Natassia, Galabina Yordanova, David Yuan, Oana Stroe, Gemma Wood, Agata Laydon, Augustin Žídek, Tim Green, Kathryn Tunyasuvunakool, Stig Petersen, John Jumper, Ellen Clancy, Richard Green, Ankur Vora, Mira Lutfi, Michael Figurnov, Andrew Cowie, Nicole Hobbs, Pushmeet Kohli, Gerard Kleywegt, Ewan Birney, Demis Hassabis, Sameer Velankar", "authorCount": 27, "firstAuthorAffiliation": "European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK", "isReferencedByCount": 7854, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "DeepMind", "funderIds": "10.13039/100017149", "url": "https://doi.org/10.1093/nar/gkab1061", "pdfUrl": "https://academic.oup.com/nar/article-pdf/50/D1/D439/43502749/gkab1061.pdf", "abstract": "Abstract The AlphaFold Protein Structure Database (AlphaFold DB, https://alphafold.ebi.ac.uk) is an openly accessible, extensive database of high-accuracy protein-structure predictions. Powered by AlphaFold v2.0 of DeepMind, it has enabled an unprecedented expansion of the structural coverage of the known protein-sequence space. AlphaFold DB provides programmatic access to and interactive visualization of predicted atomic coordinates, per-residue and pairwise model-confidence estimates and predicted aligned errors. The initial release of AlphaFold DB contains over 360,000 predicted structures across 21 model-organism proteomes, which will soon be expanded to cover most of the (over 100 million) representative sequences from the UniRef90 data set.", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1145/37402.37422", "doi": "10.1145/37402.37422", "title": "Marching cubes: A high resolution 3D surface construction algorithm", "publicationYear": 1987, "publicationDate": "1987-08", "type": "journal-article", "publisher": "Association for Computing Machinery (ACM)", "containerTitle": "ACM SIGGRAPH Computer Graphics", "volume": "21", "issue": "4", "page": "163-169", "issn": "0097-8930", "isbn": null, "authors": "William E. Lorensen, Harvey E. Cline", "authorCount": 2, "firstAuthorAffiliation": "General Electric Company, Schenectady, NY", "isReferencedByCount": 7853, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "https://www.acm.org/publications/policies/copyright_policy#Background", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1145/37402.37422", "pdfUrl": null, "abstract": "We present a new algorithm, called marching cubes , that creates triangle models of constant density surfaces from 3D medical data. Using a divide-and-conquer approach to generate inter-slice connectivity, we create a case table that defines triangle topology. The algorithm processes the 3D medical data in scan-line order and calculates triangle vertices using linear interpolation. We find the gradient of the original data, normalize it, and use it as a basis for shading the models. The detail in images produced from the generated surface models is the result of maintaining the inter-slice connectivity, surface data, and gradient information present in the original 3D data. Results from computed tomography (CT), magnetic resonance (MR), and single-photon emission computed tomography (SPECT) illustrate the quality and functionality of marching cubes . We also discuss improvements that decrease processing time and add solid modeling capabilities.", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1177/1745691610393980", "doi": "10.1177/1745691610393980", "title": "Amazon's Mechanical Turk", "publicationYear": 2011, "publicationDate": "2011-01", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Perspectives on Psychological Science", "volume": "6", "issue": "1", "page": "3-5", "issn": "1745-6916, 1745-6924", "isbn": null, "authors": "Michael Buhrmester, Tracy Kwang, Samuel D. Gosling", "authorCount": 3, "firstAuthorAffiliation": "Department of Psychology, University of Texas at Austin", "isReferencedByCount": 7764, "referenceCount": 5, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/1745691610393980", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/1745691610393980", "abstract": "Amazon’s Mechanical Turk (MTurk) is a relatively new website that contains the major elements required to conduct research: an integrated participant compensation system; a large participant pool; and a streamlined process of study design, participant recruitment, and data collection. In this article, we describe and evaluate the potential contributions of MTurk to psychology and other social sciences. Findings indicate that (a) MTurk participants are slightly more demographically diverse than are standard Internet samples and are significantly more diverse than typical American college samples; (b) participation is affected by compensation rate and task length, but participants can still be recruited rapidly and inexpensively; (c) realistic compensation rates do not affect data quality; and (d) the data obtained are at least as reliable as those obtained via traditional methods. Overall, MTurk can be used to obtain high-quality data inexpensively and rapidly.", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1038/nature26160", "doi": "10.1038/nature26160", "title": "Unconventional superconductivity in magic-angle graphene superlattices", "publicationYear": 2018, "publicationDate": "2018-04", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "556", "issue": "7699", "page": "43-50", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Yuan Cao, Valla Fatemi, Shiang Fang, Kenji Watanabe, Takashi Taniguchi, Efthimios Kaxiras, Pablo Jarillo-Herrero", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 7684, "referenceCount": 65, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nature26160", "pdfUrl": "http://www.nature.com/articles/nature26160.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1103/physrevb.40.3616", "doi": "10.1103/physrevb.40.3616", "title": "High-precision sampling for Brillouin-zone integration in metals", "publicationYear": 1989, "publicationDate": "1989-08-15", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Physical Review B", "volume": "40", "issue": "6", "page": "3616-3621", "issn": "0163-1829", "isbn": null, "authors": "M. Methfessel, A. T. Paxton", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 7492, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": "http://link.aps.org/licenses/aps-default-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1103/physrevb.40.3616", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1109/tcsvt.2012.2221191", "doi": "10.1109/tcsvt.2012.2221191", "title": "Overview of the High Efficiency Video Coding (HEVC) Standard", "publicationYear": 2012, "publicationDate": "2012-12", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Circuits and Systems for Video Technology", "volume": "22", "issue": "12", "page": "1649-1668", "issn": "1051-8215, 1558-2205", "isbn": null, "authors": "Gary J. Sullivan, Jens-Rainer Ohm, Woo-Jin Han, Thomas Wiegand", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 7486, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tcsvt.2012.2221191", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1016/j.cpc.2021.108033", "doi": "10.1016/j.cpc.2021.108033", "title": "VASPKIT: A user-friendly interface facilitating high-throughput computing and analysis using VASP code", "publicationYear": 2021, "publicationDate": "2021-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Computer Physics Communications", "volume": "267", "issue": null, "page": "108033", "issn": "0010-4655", "isbn": null, "authors": "Vei Wang, Nan Xu, Jin-Cheng Liu, Gang Tang, Wen-Tong Geng", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 7372, "referenceCount": 98, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.cpc.2021.108033", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1126/science.235.4793.1196", "doi": "10.1126/science.235.4793.1196", "title": "The Resonating Valence Bond State in La <sub>2</sub> CuO <sub>4</sub> and Superconductivity", "publicationYear": 1987, "publicationDate": "1987-03-06", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "235", "issue": "4793", "page": "1196-1198", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "P. W. Anderson", "authorCount": 1, "firstAuthorAffiliation": "Department of Physics, Princeton University, Princeton, NJ 08544.", "isReferencedByCount": 7284, "referenceCount": 28, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.235.4793.1196", "pdfUrl": null, "abstract": "The oxide superconductors, particularly those recently discovered that are based on La 2 CuO 4 , have a set of peculiarities that suggest a common, unique mechanism: they tend in every case to occur near a metal-insulator transition into an odd-electron insulator with peculiar magnetic properties. This insulating phase is proposed to be the long-sought \"resonating-valence-bond\" state or \"quantum spin liquid\" hypothesized in 1973. This insulating magnetic phase is favored by low spin, low dimensionality, and magnetic frustration. The preexisting magnetic singlet pairs of the insulating state become charged superconducting pairs when the insulator is doped sufficiently strongly. The mechanism for superconductivity is hence predominantly electronic and magnetic, although weak phonon interactions may favor the state. Many unusual properties are predicted, especially of the insulating state.", "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1021/ja01619a008", "doi": "10.1021/ja01619a008", "title": "The Temperature Dependence of Relaxation Mechanisms in Amorphous Polymers and Other Glass-forming Liquids", "publicationYear": 1955, "publicationDate": "1955-07", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "77", "issue": "14", "page": "3701-3707", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Malcolm L. Williams, Robert F. Landel, John D. Ferry", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 7192, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/ja01619a008", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.1038/nature03090", "doi": "10.1038/nature03090", "title": "Room-temperature fabrication of transparent flexible thin-film transistors using amorphous oxide semiconductors", "publicationYear": 2004, "publicationDate": "2004-11", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "432", "issue": "7016", "page": "488-492", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Kenji Nomura, Hiromichi Ohta, Akihiro Takagi, Toshio Kamiya, Masahiro Hirano, Hideo Hosono", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 7159, "referenceCount": 26, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nature03090", "pdfUrl": "http://www.nature.com/articles/nature03090.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "9WddRhkpMxzPxbohI", "_dataset_id": "ht85FQO4K7dxTUpo9"}
{"paperId": "10.22323/1.297.0272", "doi": "10.22323/1.297.0272", "title": "Coupling measurements for the 125 GeV Higgs Boson in the fermion decay channels with the ATLAS detector5 GeV Higgs Boson in the fermion decay channels", "publicationYear": 2017, "publicationDate": "2017-09-12", "type": "proceedings-article", "publisher": "Sissa Medialab", "containerTitle": "Proceedings of XXV International Workshop on Deep-Inelastic Scattering and Related Subjects — PoS(DIS2017)", "volume": null, "issue": null, "page": "272", "issn": null, "isbn": null, "authors": "Duc Bao TA, ATLAS Collaboration", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22323/1.297.0272", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "wavbPRUqk76QEvsjN", "_dataset_id": "HEUtkTF7mk4gH0mpb"}
{"paperId": "10.22323/1.340.0616", "doi": "10.22323/1.340.0616", "title": "Measurements of Higgs boson properties using a combination of different Higgs decay channels", "publicationYear": 2019, "publicationDate": "2019-08-02", "type": "proceedings-article", "publisher": "Sissa Medialab", "containerTitle": "Proceedings of The 39th International Conference on High Energy Physics — PoS(ICHEP2018)", "volume": null, "issue": null, "page": "616", "issn": null, "isbn": null, "authors": "Nicolas Morange, ATLAS Collaboration", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22323/1.340.0616", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "wavbPRUqk76QEvsjN", "_dataset_id": "HEUtkTF7mk4gH0mpb"}
{"paperId": "10.22323/1.282.0407", "doi": "10.22323/1.282.0407", "title": "Search for invisible decay modes of the Higgs boson with the ATLAS detector.", "publicationYear": 2017, "publicationDate": "2017-02-06", "type": "proceedings-article", "publisher": "Sissa Medialab", "containerTitle": "Proceedings of 38th International Conference on High Energy Physics — PoS(ICHEP2016)", "volume": null, "issue": null, "page": "407", "issn": null, "isbn": null, "authors": "Monica Trovatelli, ATLAS Collaboration", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22323/1.282.0407", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "wavbPRUqk76QEvsjN", "_dataset_id": "HEUtkTF7mk4gH0mpb"}
{"paperId": "10.1063/1.4826769", "doi": "10.1063/1.4826769", "title": "Search for the standard model Higgs boson through the H → ZZ decay channels with the ATLAS detector", "publicationYear": 2013, "publicationDate": "2013", "type": "proceedings-article", "publisher": "AIP", "containerTitle": "AIP Conference Proceedings", "volume": null, "issue": null, "page": "262-264", "issn": "0094-243X", "isbn": null, "authors": "Jochen Meyer, ATLAS Collaboration", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1063/1.4826769", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "wavbPRUqk76QEvsjN", "_dataset_id": "HEUtkTF7mk4gH0mpb"}
{"paperId": "10.22323/1.282.0415", "doi": "10.22323/1.282.0415", "title": "Search for the decay of the Higgs boson into two nMSSM pseudo-scalar particles.", "publicationYear": 2017, "publicationDate": "2017-02-06", "type": "proceedings-article", "publisher": "Sissa Medialab", "containerTitle": "Proceedings of 38th International Conference on High Energy Physics — PoS(ICHEP2016)", "volume": null, "issue": null, "page": "415", "issn": null, "isbn": null, "authors": "Lidija Zivkovic, ATLAS Collaboration", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22323/1.282.0415", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "wavbPRUqk76QEvsjN", "_dataset_id": "HEUtkTF7mk4gH0mpb"}
{"paperId": "10.22323/1.390.0093", "doi": "10.22323/1.390.0093", "title": "Higgs Boson measurements in the H$\\rightarrow$WW$\\rightarrow\\ell\\nu\\ell\\nu$ decay channel", "publicationYear": 2020, "publicationDate": "2020-12-01", "type": "proceedings-article", "publisher": "Sissa Medialab", "containerTitle": "Proceedings of 40th International Conference on High Energy physics — PoS(ICHEP2020)", "volume": null, "issue": null, "page": "093", "issn": null, "isbn": null, "authors": "Anamika Aggarwal, ATLAS Collaboration", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22323/1.390.0093", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "wavbPRUqk76QEvsjN", "_dataset_id": "HEUtkTF7mk4gH0mpb"}
{"paperId": "10.22323/1.314.0293", "doi": "10.22323/1.314.0293", "title": "Search for the decay of the Higgs boson into two nMSSM pseudo-scalar particles.", "publicationYear": 2017, "publicationDate": "2017-10-20", "type": "proceedings-article", "publisher": "Sissa Medialab", "containerTitle": "Proceedings of The European Physical Society Conference on High Energy Physics — PoS(EPS-HEP2017)", "volume": null, "issue": null, "page": "293", "issn": null, "isbn": null, "authors": "Michel Janus, ATLAS Collaboration", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22323/1.314.0293", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "wavbPRUqk76QEvsjN", "_dataset_id": "HEUtkTF7mk4gH0mpb"}
{"paperId": "10.22323/1.245.0082", "doi": "10.22323/1.245.0082", "title": "Standard Model Higgs boson production in the decay mode H-&gt;bb in association with a W or Z boson for High Luminosity LHC Running", "publicationYear": 2016, "publicationDate": "2016-11-28", "type": "proceedings-article", "publisher": "Sissa Medialab", "containerTitle": "Proceedings of XXVII International Symposium on Lepton Photon Interactions at High Energies — PoS(LeptonPhoton2015)", "volume": null, "issue": null, "page": "082", "issn": null, "isbn": null, "authors": "Flavia De Almeida Dias, ATLAS Collaboration", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22323/1.245.0082", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "wavbPRUqk76QEvsjN", "_dataset_id": "HEUtkTF7mk4gH0mpb"}
{"paperId": "10.22323/1.314.0288", "doi": "10.22323/1.314.0288", "title": "Measurement of the Higgs boson coupling properties in the diphoton and $ZZ$ decay channels using the ATLAS detector", "publicationYear": 2017, "publicationDate": "2017-11-27", "type": "proceedings-article", "publisher": "Sissa Medialab", "containerTitle": "Proceedings of The European Physical Society Conference on High Energy Physics — PoS(EPS-HEP2017)", "volume": null, "issue": null, "page": "288", "issn": null, "isbn": null, "authors": "Ruchi Gupta, ATLAS Collaboration", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22323/1.314.0288", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "wavbPRUqk76QEvsjN", "_dataset_id": "HEUtkTF7mk4gH0mpb"}
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{"paperId": "10.1016/j.bpj.2024.11.2193", "doi": "10.1016/j.bpj.2024.11.2193", "title": "BPS2025 - Concentration-dependent role of apolipoprotein E in amyloid beta clearance by human astrocytes", "publicationYear": 2025, "publicationDate": "2025-02", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Biophysical Journal", "volume": "124", "issue": "3", "page": "407a-408a", "issn": "0006-3495", "isbn": null, "authors": "Kamila Nurmakova, Zachary Levine", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.bpj.2024.11.2193", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1212/wnl.0000000000205068", "doi": "10.1212/wnl.0000000000205068", "title": "Binding Characteristics of PRX012 Surrogate Demonstrate Potent Engagement of Toxic Amyloid Beta Protofibrils and Robust Clearance of Pyroglutamate-modified Amyloid Beta (P7-9.003)", "publicationYear": 2024, "publicationDate": "2024-04-09", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Neurology", "volume": "102", "issue": "7_supplement_1", "page": null, "issn": "0028-3878, 1526-632X", "isbn": null, "authors": "Brian Campbell, Gang Zhang, Joshua Salmans, Abderrahman Elmaarouf, Stephen Tam, Amir Porat, Michael Skov, Philip Dolan, Gene Kinney, Wagner Zago", "authorCount": 10, "firstAuthorAffiliation": "Prothena Biosciences Inc", "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1212/wnl.0000000000205068", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.2139/ssrn.5217308", "doi": "10.2139/ssrn.5217308", "title": "Polystyrene Nanoplastics Induce Alzheimer's Disease Through Itpkb-Mediated Neuroinflammation, Mitochondrial Dysfunction, and Compromised Amyloid-Beta Clearance", "publicationYear": 2025, "publicationDate": "2025", "type": "posted-content", "publisher": "Elsevier BV", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Junjie Shao, Amin Guo, Shuangshuang Tian, Fang Zhang, Junhu Li, Yanqin Liu, Xiu-zhao Fan, Xiaoshuang Zhou", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.5217308", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1016/s0016-5085(26)03414-1", "doi": "10.1016/s0016-5085(26)03414-1", "title": "525 REVERSING LIVER SINUSOIDAL ENDOTHELIAL AGING RESTORES CLEARANCE OF AMYLOID BETA AND LDL CHOLESTEROL", "publicationYear": 2026, "publicationDate": "2026-05", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gastroenterology", "volume": "170", "issue": "6", "page": "S-1383", "issn": "0016-5085", "isbn": null, "authors": "Sam de Leve, Xiangdong Wang, Helia Alavifard, Lily Dara, Laurie DeLeve", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0016-5085(26)03414-1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1212/wnl.0000000000205138", "doi": "10.1212/wnl.0000000000205138", "title": "Dual Amyloid Beta/Tau Vaccine PRX123 Surrogate Results in Robust Clearance of Amyloid Plaques in Brains of Aggressive APP/PS1 Mouse Model (P7-9.015)", "publicationYear": 2024, "publicationDate": "2024-04-09", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Neurology", "volume": "102", "issue": "7_supplement_1", "page": null, "issn": "0028-3878, 1526-632X", "isbn": null, "authors": "Robin Barbour, Clara Tourino, Alyssa Trumble, LeeAnn Louie, Gene Kinney, Wagner Zago, Brian Campbell", "authorCount": 7, "firstAuthorAffiliation": "Current and former employees of Prothena Biosciences Inc", "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1212/wnl.0000000000205138", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1016/s0016-5107(26)03345-6", "doi": "10.1016/s0016-5107(26)03345-6", "title": "525 REVERSING LIVER SINUSOIDAL ENDOTHELIAL AGING RESTORES CLEARANCE OF AMYLOID BETA AND LDL CHOLESTEROL", "publicationYear": 2026, "publicationDate": "2026-05", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gastrointestinal Endoscopy", "volume": "103", "issue": "5", "page": "S-1383", "issn": "0016-5107", "isbn": null, "authors": "Sam de Leve, Xiangdong Wang, Helia Alavifard, Lily Dara, Laurie DeLeve", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0016-5107(26)03345-6", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1101/2025.11.14.688256", "doi": "10.1101/2025.11.14.688256", "title": "Repeat Opioid Use Modulates Microglia Activity and Amyloid Beta Clearance in a Mouse Model of Alzheimer’s Disease", "publicationYear": 2025, "publicationDate": "2025-11-16", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Joseph V Gogola, Sung Won Stephanie Wee, Alfredo J Garcia", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 64, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "NIH, NIH, NIH, NIH", "funderIds": null, "url": "https://doi.org/10.1101/2025.11.14.688256", "pdfUrl": null, "abstract": "Abstract In addition to driving dependency and overdose, illicit use of opioids, such as fentanyl, is linked to the risk for cognitive decline and dementia. Growing evidence also indicates that opioid use is associated with pathological features, paralleled early in Alzheimer’s disease (AD), which raises the possibility of the involvement of mechanistic interactions between opioid use and AD progression. Here, we investigate how chronic fentanyl use (i.e., 20 days) influences the neuroimmune state, microglial activity, and amyloid burden in wildtype and APPPS1-21 mice, a transgenic model of AD. In wild-type mice, fentanyl use promoted a pro-inflammatory state without increasing the incidence of disease-associated microglia. In APPPS1-21 mice, chronic fentanyl use led to a shift favoring an anti-inflammatory state, which was associated with increased microglia clustering and activation at Aβ plaques, increased Aβ internalization in plaque-associated activated microglia, decreased soluble Aβ, and decreased plaque burden. Our findings indicate that chronic fentanyl use fundamentally changes the trajectory of neuroimmune activity and features characteristic of early AD by enabling microglia to enhance Aβ clearance. The interactions demonstrate how substance use can reshape the neuroimmune landscape in neurodegenerative disease, emphasizing the importance of tailored treatment strategies.", "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1016/j.sleep.2025.106992", "doi": "10.1016/j.sleep.2025.106992", "title": "Modelling Amyloid-beta clearance dynamics across sleep-wake cycles in healthy conditions", "publicationYear": 2026, "publicationDate": "2026-02", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Sleep Medicine", "volume": "138", "issue": null, "page": "106992", "issn": "1389-9457", "isbn": null, "authors": "S. Sangeet, A. D'Rozario, C. Phillips, C. Hoyos, S. Postnova", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Woolcock Institute of Medical Research, University of Sydney", "funderIds": "10.13039/100031320, 10.13039/501100001774", "url": "https://doi.org/10.1016/j.sleep.2025.106992", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.2139/ssrn.5336841", "doi": "10.2139/ssrn.5336841", "title": "Rapid Brain Hemorrhage in Mice Treated with Anti-Amyloid-Beta Immunotherapy in the Absence of Amyloid Plaque Clearance or Marked Astrocyte Dysfunction", "publicationYear": 2025, "publicationDate": "2025", "type": "posted-content", "publisher": "Elsevier BV", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Rebecca  L. Gillani, Maria V. Sanchez-Mico, Moustafa Algamal, Sarena Abdallah, Sara Whiteman, Rachel Paredes, Wadzanai  H. Ndambakuwa, Uma Sanker, Ashley  A. Scherlek, Steven  S. Hou, Thierry Bussière, Michael Levy, Brian  J. Bacskai", "authorCount": 13, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.5336841", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.64898/2026.04.07.717091", "doi": "10.64898/2026.04.07.717091", "title": "Investigating a Relation between Amyloid Beta Plaque Burden and Accumulated Neurotoxicity Caused by Amyloid Beta Oligomers", "publicationYear": 2026, "publicationDate": "2026-04-10", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Andrey V. Kuznetsov", "authorCount": 1, "firstAuthorAffiliation": "Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910, USA", "isReferencedByCount": 1, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "U.S. National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.64898/2026.04.07.717091", "pdfUrl": null, "abstract": "Abstract Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ), yet the specific link between plaque burden and cognitive decline remains a subject of intense investigation. This paper presents a mathematical model that simulates the coupled dynamics of Aβ monomers, soluble oligomers, and fibrillar species in the brain tissue. By modifying existing moment equations to include a dedicated conservation equation for Aβ monomers, the model explores how various microscopic processes, such as primary nucleation, surface-catalyzed secondary nucleation, fibril elongation, and fragmentation, contribute to macroscopic disease progression. Central to this study is the concept of “accumulated neurotoxicity” as a surrogate marker of biological age, defined as the time-integrated concentration of soluble Aβ oligomers. Unlike plaque burden, accumulated neurotoxicity cannot be reversed, and the harm it causes depends critically on the sequence of events that produced it. Numerical results demonstrate that while plaque burden and neurotoxicity both increase over time, their relationship is non-linear and highly sensitive to the efficiency of protein degradation machinery. Specifically, impaired degradation leads to a rapid advancement of biological age relative to calendar age. The model further identifies oligomer dissociation and fibril fragmentation as potential protective mechanisms that can counterintuitively reduce neurotoxic burden by diverting monomers away from the soluble oligomer pool. These findings provide a quantitative framework for understanding why individuals with similar plaque burdens may experience vastly different cognitive outcomes, underscoring the importance of targeting soluble oligomers early in therapeutic interventions.", "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1007/s12035-024-04320-3", "doi": "10.1007/s12035-024-04320-3", "title": "Long-Term High-Fat Diet Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta", "publicationYear": 2025, "publicationDate": "2025-01", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Molecular Neurobiology", "volume": "62", "issue": "1", "page": "1079-1093", "issn": "0893-7648, 1559-1182", "isbn": null, "authors": "Wei Peng, Ye Yuan, Jingna Lei, Yi Zhao, Yan Li, Qiumin Qu, Jin Wang", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 21, "referenceCount": 59, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s12035-024-04320-3", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s12035-024-04320-3.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.2139/ssrn.4560767", "doi": "10.2139/ssrn.4560767", "title": "Synchrotron Fourier Transform Infrared Microspectroscopy (Sftirm) Analysis of Beta Amyloid Aggregation/Clearance in Al-Induced Alzheimer’S’ Disease in Rat Brain Hippocampal Tissue", "publicationYear": 2023, "publicationDate": "2023", "type": "posted-content", "publisher": "Elsevier BV", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Safaa  K. H. Khalil, Waleed El hotaby, Gehan  Abdel-Raouf Ahmed, Gihan Kamel, Hadeer  H.A. Sherif, Lamyaa Abbas", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.4560767", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1016/j.carbpol.2026.125541", "doi": "10.1016/j.carbpol.2026.125541", "title": "Corrigendum to “Heparan sulfate from porcine mucosa promotes amyloid-beta clearance in APP/PS1 mice and alleviates Alzheimer's pathology” [Carbohydrate Polymers 285 (2022) 119205]", "publicationYear": 2026, "publicationDate": "2026-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Carbohydrate Polymers", "volume": "388", "issue": null, "page": "125541", "issn": "0144-8617", "isbn": null, "authors": "Lidan Wu, Wenjie Jiang, Na Zhao, Fengshan Wang", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.carbpol.2026.125541", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.53347/rid-167371", "doi": "10.53347/rid-167371", "title": "Amyloid beta related angiitis", "publicationYear": 2023, "publicationDate": "2023-04-26", "type": "reference-entry", "publisher": "Radiopaedia.org", "containerTitle": "Radiopaedia.org", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Francis Deng", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.53347/rid-167371", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1038/s41398-024-03019-2", "doi": "10.1038/s41398-024-03019-2", "title": "Switch to phagocytic microglia by CSFR1 inhibition drives amyloid-beta clearance from glutamatergic terminals rescuing LTP in acute hippocampal slices", "publicationYear": 2024, "publicationDate": "2024-08-23", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Translational Psychiatry", "volume": "14", "issue": "1", "page": null, "issn": "2158-3188", "isbn": null, "authors": "Gaia Piccioni, Nunzia Maisto, Asia d’Ettorre, Georgios Strimpakos, Robert Nisticò, Viviana Triaca, Dalila Mango", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 10, "referenceCount": 98, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/s41398-024-03019-2", "pdfUrl": "https://www.nature.com/articles/s41398-024-03019-2.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.26434/chemrxiv-2024-z4k0k", "doi": "10.26434/chemrxiv-2024-z4k0k", "title": "Identification of Inhibitors for Amyloid-beta in Alzheimer's Disease and Cerebral Amyloid Angiopathy", "publicationYear": 2024, "publicationDate": "2024-11-08", "type": "posted-content", "publisher": "American Chemical Society (ACS)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Aarav Vakani, Gaurav Sharma", "authorCount": 2, "firstAuthorAffiliation": "Wake Early College of Health and Sciences", "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26434/chemrxiv-2024-z4k0k", "pdfUrl": null, "abstract": "The neurodegenerative illness Alzheimer's disease causes 70% of cases of dementia, leading to the impairment of behavioral and cognitive functions such as language, attention, memory, judgment, and reasoning. The disease is caused by the buildup of amyloid fibrils in brain neurons. Recently, in 2023, a new type of amyloid fibril extracted from the leptomeninges of Alzheimer’s disease patients has been resolved. This structure has a different shape and size than the earlier 2019 structure. We hypothesize that since the two structures are different, the ligands binding and inhibiting the structure should also be different. Therefore, a rigorous research process was undertaken, including molecular docking simulations to identify inhibitors that can bind at the fibril interface and prevent fibril formation. A total of 8216 ligands were docked on the amyloid protein, and the best five ligands based on the binding interactions were selected for further evaluation. These results were further validated using a machine-learning technique called P2Rank. Finally, molecular docking and molecular dynamics simulations in the protein-fibril complex were performed to understand the interactions between amyloid peptide/fibril and the plasma membrane. The thoroughness of our research process instills confidence in the potential of developing inhibitors that can prevent fibril formation, potentially leading to new treatments for the disease.", "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1242/prelights.43263", "doi": "10.1242/prelights.43263", "title": "Exogenous Amyloid Sequences: Their Role in Amyloid-Beta Heterotypic Aggregation", "publicationYear": 2026, "publicationDate": "2026-04-15", "type": "posted-content", "publisher": "The Company of Biologists", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Cyntia Alves Conceição", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1242/prelights.43263", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.32388/2esvyp.2", "doi": "10.32388/2esvyp.2", "title": "Amyloid Beta Revisited: A Versatile Immune Polypeptide", "publicationYear": 2026, "publicationDate": "2026-04-22", "type": "posted-content", "publisher": "Qeios Ltd", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Patrick Slama", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 138, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.32388/2esvyp.2", "pdfUrl": "https://www.qeios.com/read/2ESVYP.2/pdf", "abstract": "Alzheimer's disease affects about fifty million people worldwide. Its main symptoms are the formation of amyloid deposits and of neurofibrillary tangles, and cognition loss. To date, no clear etiology for this disease could be identified. Metal ions have been shown to accumulate in amyloid deposits. Moreover, multiple infections have been shown to be risk factors for the development of Alzheimer's and other dementia, with vaccines playing protective roles. I will here elaborate on the likelihood that Amyloid b is not a toxic molecule, but a protective protein fragment, targeted both against infections and metals. A combination of chemical and biological exposures, with metals playing a key role, would thus be key factors in the triggering of Alzheimer's disease.", "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.32388/2esvyp", "doi": "10.32388/2esvyp", "title": "Amyloid Beta Revisited: A Versatile Immune Polypeptide", "publicationYear": 2026, "publicationDate": "2026-03-07", "type": "posted-content", "publisher": "Qeios Ltd", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Patrick Slama", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 95, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.32388/2esvyp", "pdfUrl": "https://www.qeios.com/read/2ESVYP/pdf", "abstract": "Alzheimer's disease affects about fifty million people worldwide. Its main symptoms are the formation of amyloid deposits and of neurofibrillary tangles, and cognition loss. To date, no clear etiology for this disease could be identified. I will here elaborate on the likelihood that Amyloid b is not a toxic molecule but a protective protein fragment, and that a combination of chemical and biological exposures, with metals playing a key role, are the triggering factors for Alzheimer's type dementia.", "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.4103/nrr.nrr-d-24-00865", "doi": "10.4103/nrr.nrr-d-24-00865", "title": "Systematic review of amyloid-beta clearance proteins from the brain to the periphery: implications for Alzheimer’s disease diagnosis and therapeutic targets", "publicationYear": 2025, "publicationDate": "2025-12", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Neural Regeneration Research", "volume": "20", "issue": "12", "page": "3574-3590", "issn": "1673-5374, 1876-7958", "isbn": null, "authors": "Letian Huang, Mingyue Liu, Ze Li, Bing Li, Jiahe Wang, Ke Zhang", "authorCount": 6, "firstAuthorAffiliation": "Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China", "isReferencedByCount": 9, "referenceCount": 189, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4103/nrr.nrr-d-24-00865", "pdfUrl": null, "abstract": "Amyloid-beta clearance plays a key role in the pathogenesis of Alzheimer’s disease. However, the variation in functional proteins involved in amyloid-beta clearance and their correlation with amyloid-beta levels remain unclear. In this study, we conducted meta-analyses and a systematic review using studies from the PubMed, Embase, Web of Science, and Cochrane Library databases, including journal articles published from inception to June 30, 2023. The inclusion criteria included studies comparing the levels of functional proteins associated with amyloid-beta clearance in the blood, cerebrospinal fluid, and brain of healthy controls, patients with mild cognitive impairment, and patients with Alzheimer’s disease. Additionally, we analyzed the correlation between these functional proteins and amyloid-beta levels in patients with Alzheimer’s disease. The methodological quality of the studies was assessed via the Newcastle‒Ottawa Scale. Owing to heterogeneity, we utilized either a fixed-effect or random-effect model to assess the 95% confidence interval (CI) of the standard mean difference (SMD) among healthy controls, patients with mild cognitive impairment, and patients with Alzheimer’s disease. The findings revealed significant alterations in the levels of insulin-degrading enzymes, neprilysin, matrix metalloproteinase-9, cathepsin D, receptor for advanced glycation end products, and P-glycoprotein in the brains of patients with Alzheimer’s disease, patients with mild cognitive impairment, and healthy controls. In cerebrospinal fluid, the levels of triggering receptor expressed on myeloid cells 2 and ubiquitin C-terminal hydrolase L1 are altered, whereas the levels of TREM2, CD40, CD40L, CD14, CD22, cathepsin D, cystatin C, and α2 M in peripheral blood differ. Notably, TREM2 and cathepsin D showed changes in both brain (SMD = 0.31, 95% CI: 0.16–0.47, P &lt; 0.001, I 2 = 78.4%; SMD = 1.24, 95% CI: 0.01–2.48, P = 0.048, I 2 = 90.1%) and peripheral blood (SMD = 1.01, 95% CI: 0.35–1.66, P = 0.003, I 2 = 96.5%; SMD = 7.55, 95% CI: 3.92–11.18, P &lt; 0.001, I 2 = 98.2%) samples. Furthermore, correlations were observed between amyloid-beta levels and the levels of TREM2 ( r = 0.16, 95% CI: 0.04–0.28, P = 0.009, I 2 = 74.7%), neprilysin ( r = –0.47, 95% CI: –0.80–0.14, P = 0.005, I 2 = 76.1%), and P-glycoprotein ( r = –0.31, 95% CI: –0.51–0.11, P = 0.002, I 2 = 0.0%) in patients with Alzheimer’s disease. These findings suggest that triggering receptor expressed on myeloid cells 2 and cathepsin D could serve as potential diagnostic biomarkers for Alzheimer’s disease, whereas triggering receptor expressed on myeloid cells 2, neprilysin, and P-glycoprotein may represent potential therapeutic targets.", "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.4103/1673-5374.391305", "doi": "10.4103/1673-5374.391305", "title": "Liver as a new target organ in Alzheimer’s disease: insight from cholesterol metabolism and its role in amyloid-beta clearance", "publicationYear": 2025, "publicationDate": "2025-03", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Neural Regeneration Research", "volume": "20", "issue": "3", "page": "695-714", "issn": "1673-5374, 1876-7958", "isbn": null, "authors": "Beibei Wu, Yuqing Liu, Hongli Li, Lemei Zhu, Lingfeng Zeng, Zhen Zhang, Weijun Peng", "authorCount": 7, "firstAuthorAffiliation": "Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China", "isReferencedByCount": 15, "referenceCount": 272, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4103/1673-5374.391305", "pdfUrl": null, "abstract": "Alzheimer’s disease, the primary cause of dementia, is characterized by neuropathologies, such as amyloid plaques, synaptic and neuronal degeneration, and neurofibrillary tangles. Although amyloid plaques are the primary characteristic of Alzheimer’s disease in the central nervous system and peripheral organs, targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer’s disease treatment. Metabolic abnormalities are commonly observed in patients with Alzheimer’s disease. The liver is the primary peripheral organ involved in amyloid-beta metabolism, playing a crucial role in the pathophysiology of Alzheimer’s disease. Notably, impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer’s disease. In this review, we explore the underlying causes of Alzheimer’s disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol metabolism. Furthermore, we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer’s disease.", "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.2139/ssrn.5886175", "doi": "10.2139/ssrn.5886175", "title": "Anti-amyloid-β monoclonal antibodies induce brain atrophy through amyloid clearance cascade reaction", "publicationYear": 2025, "publicationDate": "2025", "type": "posted-content", "publisher": "Elsevier BV", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yu-Hui Qiu, He-Jin Wang, Min-Hua Zheng, Shijie Zhang, See PDF", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.5886175", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.2139/ssrn.7078701", "doi": "10.2139/ssrn.7078701", "title": "N-Terminal-Targeted Anti-Amyloid-β Monoclonal Antibodies Induce Brain Atrophy through Amyloid Clearance Cascade Reaction", "publicationYear": 2026, "publicationDate": "2026", "type": "posted-content", "publisher": "Elsevier BV", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yu-Hui Qiu, He-Jin Wang, Shijie Zhang, See PDF", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.7078701", "pdfUrl": null, "abstract": "Three anti-amyloid-β (Aβ) monoclonal antibodies (mAbs) have been approved by FDA for&amp;nbsp;Alzheimer’s disease(AD) therapy. However, a reduction of brain volume was also been observed. In this analysis, we aimed to identify whether the brain volume reduction was induced by N-terminal-targeted mAbs via Aβ clearance. All the published RCTs of mAbs in AD were included, which reported detailed magnetic resonance imaging data. The literature search identified&amp;nbsp;totally 22 RCTs. The&amp;nbsp;N-terminal-targeted mAbs&amp;nbsp;accelerated whole-brain atrophy and ventricular enlargement,&amp;nbsp;with limited hippocampal&amp;nbsp;atrophy. The N-terminal-targeted mAbs significantly reduced amyloid-PET. Additionally, amyloid-PET change was correlated with&amp;nbsp;the whole-brain atrophy and the ventricular&amp;nbsp;enlargements. The mediation analysis showed that the association between&amp;nbsp;N-terminal-targeted mAbs&amp;nbsp;and whole-brain and ventricular volumetric changes were mediated by amyloid-PET reduction. These findings constitute a “phenomenological theory”: The whole-brain atrophy and ventricular enlargement were mainly induced by N-terminal-targeted mAbs through amyloid clearance cascade reaction.", "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.3389/fnagi.2026.1801267", "doi": "10.3389/fnagi.2026.1801267", "title": "Aging modulates amyloid clearance kinetics during anti-amyloid therapy: evidence from real-world serial amyloid PET", "publicationYear": 2026, "publicationDate": "2026-05-08", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Aging Neuroscience", "volume": "18", "issue": null, "page": null, "issn": "1663-4365", "isbn": null, "authors": "Tomomichi Iizuka, Toshiaki Watanabe, Masashi Kameyama", "authorCount": 3, "firstAuthorAffiliation": "Center for Dementia, Fukujuji Hospital", "isReferencedByCount": 1, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3389/fnagi.2026.1801267", "pdfUrl": null, "abstract": "Background Anti-amyloid antibodies have been shown to reduce cerebral amyloid burden in early Alzheimer’s disease (AD), yet considerable interindividual variability in treatment-associated amyloid reduction has been observed. The biological factors underlying this variability remain unclear. In particular, the influence of aging on amyloid clearance dynamics during anti-amyloid therapy has not been well characterized in real-world clinical settings. Methods We conducted a prospective observational study of 23 patients with early-stage AD receiving lecanemab who underwent serial 18 F-flutemetamol amyloid PET at baseline and after 6 and 12 months. Amyloid burden was quantified in centiloid units. Cognitive outcomes were assessed using the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating–Sum of Boxes (CDR-SB). Baseline cerebral perfusion was evaluated using 123 I-IMP SPECT with three-dimensional stereotactic surface projection (3D-SSP) analysis. Results All participants showed reductions in amyloid burden on serial PET; however, the magnitude of reduction varied substantially across individuals. Older patients tended to exhibit larger and more rapid reductions in amyloid burden, whereas younger patients demonstrated more modest decreases despite comparable baseline amyloid levels and standardized dosing. Amyloid reduction at 6 months strongly predicted the magnitude of reduction at 12 months, suggesting that early PET changes capture subsequent amyloid clearance trajectories. Cognitive decline occurred in a subset of patients despite substantial amyloid reduction and was associated with marked baseline temporo-parietal hypoperfusion on SPECT rather than insufficient amyloid removal. Conclusion In this real-world cohort, aging appeared to influence the observable kinetics of amyloid reduction during anti-amyloid therapy. Early serial amyloid PET may provide useful information regarding longer-term amyloid dynamics, while baseline perfusion imaging may help identify patients with substantial downstream neurodegenerative burden who remain at risk for cognitive decline despite amyloid clearance. These findings highlight biological heterogeneity in treatment response and underscore the value of multimodal imaging for monitoring disease-modifying therapies in AD.", "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1007/978-981-99-9283-6_149", "doi": "10.1007/978-981-99-9283-6_149", "title": "Amyloid Beta", "publicationYear": 2024, "publicationDate": "2024", "type": "book-chapter", "publisher": "Springer Nature Singapore", "containerTitle": "Dictionary of Toxicology", "volume": null, "issue": null, "page": "60-60", "issn": null, "isbn": "9789819992829, 9789819992836", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-981-99-9283-6_149", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1111/ejn.16332/v2/review1", "doi": "10.1111/ejn.16332/v2/review1", "title": "Review for \"ArcheD, a residual neural network for prediction of cerebrospinal fluid amyloid-beta from amyloid PET images\"", "publicationYear": 2024, "publicationDate": "2024-02-29", "type": "peer-review", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1111/ejn.16332/v2/review1", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.7554/elife.111724.1.sa1", "doi": "10.7554/elife.111724.1.sa1", "title": "Reviewer #2 (Public review): Connections across regional glymphatic clearance, neural activity and amyloid-β deposition in cortex", "publicationYear": 2026, "publicationDate": "2026-07-16", "type": "peer-review", "publisher": "eLife Sciences Publications, Ltd", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.7554/elife.111724.1.sa1", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.7554/elife.111724.1.sa3", "doi": "10.7554/elife.111724.1.sa3", "title": "eLife Assessment: Connections across regional glymphatic clearance, neural activity and amyloid-β deposition in cortex", "publicationYear": 2026, "publicationDate": "2026-07-16", "type": "peer-review", "publisher": "eLife Sciences Publications, Ltd", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Amreen Mughal", "authorCount": 1, "firstAuthorAffiliation": "National Institute of Neurological Disorders and Stroke, National Institute of Health", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.7554/elife.111724.1.sa3", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.2139/ssrn.4356804", "doi": "10.2139/ssrn.4356804", "title": "ApoE Mimic Peptide COG1410 Enhances Beta-Amyloid Clearance and Improves Cognitive Function by Inducing&amp;nbsp;The Transformation of A1/ A2 Reactive Astrocytes And&amp;nbsp;Increasing the BDNF Concentration in Brain of APP/PS1 Double Transgenic Mice", "publicationYear": 2023, "publicationDate": "2023", "type": "posted-content", "publisher": "Elsevier BV", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Ying Ma, Yue Qiao, Hang Liu, Chaoying He", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.4356804", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.2139/ssrn.5178912", "doi": "10.2139/ssrn.5178912", "title": "Structural and Functional Analysis of TREM2 Interactions with Amyloid Beta Reveal Molecular Mechanisms That Mediate Phagocytosis of Oligomeric Amyloid Beta", "publicationYear": 2025, "publicationDate": "2025", "type": "posted-content", "publisher": "Elsevier BV", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Jessica Greven, Omar Osorio, Jay Nix, Jen Alexander-Brett, Thomas J. Brett", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.5178912", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.3724/zdxbyxb-2025-0549", "doi": "10.3724/zdxbyxb-2025-0549", "title": "Research progress on vascular endothelial growth factor C in meningeal lymphatic vessel-mediated clearance of amyloid &amp;beta;-protein", "publicationYear": 2026, "publicationDate": "2026-07-01", "type": "journal-article", "publisher": "China Science Publishing & Media Ltd.", "containerTitle": "Journal of Zhejiang University (Medical Sciences)", "volume": "55", "issue": "5", "page": "383-390", "issn": "1008-9292", "isbn": null, "authors": "Zhaoxie YU, Yao WANG, Yanan LI, Feng SHEN, Yanchun WANG", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 53, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3724/zdxbyxb-2025-0549", "pdfUrl": "https://www.sciengine.com/sci-open/api/v1/open/file/pdf/668C335ABB8E4FF2A2AD2C4DEC39D876", "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1111/ejn.16332/v1/review1", "doi": "10.1111/ejn.16332/v1/review1", "title": "Review for \"ArcheD, a residual neural network for prediction of cerebrospinal fluid amyloid-beta from amyloid PET images\"", "publicationYear": 2023, "publicationDate": "2023-12-06", "type": "peer-review", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1111/ejn.16332/v1/review1", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.7554/elife.111724.1.sa0", "doi": "10.7554/elife.111724.1.sa0", "title": "Reviewer #3 (Public review): Connections across regional glymphatic clearance, neural activity and amyloid-β deposition in cortex", "publicationYear": 2026, "publicationDate": "2026-07-16", "type": "peer-review", "publisher": "eLife Sciences Publications, Ltd", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.7554/elife.111724.1.sa0", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.21203/rs.3.rs-3762830/v1", "doi": "10.21203/rs.3.rs-3762830/v1", "title": "Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in 5XFAD mice", "publicationYear": 2023, "publicationDate": "2023-12-20", "type": "posted-content", "publisher": "Research Square Platform LLC", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Dilpreet Kour, Parul Khajuria, Kuhu Sharma, Alpa Sharma, Ankita Sharma, Syed Mudassir Ali, Priya Wazir, P Ramajayan, Sanghapal D. Sawant, Utpal Nandi, Zabeer Ahmed, Ajay Kumar", "authorCount": 12, "firstAuthorAffiliation": "CSIR-Indian Institute of Integrative Medicine", "isReferencedByCount": 2, "referenceCount": 40, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.21203/rs.3.rs-3762830/v1", "pdfUrl": null, "abstract": "Abstract The complex pathology of Alzheimer disease (AD) has led to failure of multiple drugs in clinical trials. We hypothesized that targeting multiple aspects AD pathology may yield better results. Therefore, we identified isobavachalcone (IBC) as a natural compound with dual activity against AD pathology. IBC caused AMPK phosphorylation through CAMKK2 to induce autophagy and inhibit NLRP3 inflammasome in primary astrocytes. The inhibition of NLRP3 inflammasome by IBC was completely reversed when autophagy was inhibited by siAMPK or bafilomycin A1. Further, the primary astrocytes treated with IBC showed a significant intracellular clearance of amyloid beta, which was added externally to the culture. However, when autophagy was inhibited by siRNA-mediated downregulation of AMPK, the clearance of amyloid beta was significantly reduced. Moreover, the inflammatory phenotype of astrocytes also displayed a sharp decline, as indicated by the reduced levels of GFAP and IL-1β. We validated the anti-Alzheimer effect of IBC by treating transgenic 5XFAD mice for two months with IBC. The 5XFAD mice showed a significant improvement in brain health as indicated by improved memory behavior in the radial arm maze test, along with better performance in the open field and rotarod tests. The data revealed that IBC upregulated the autophagic proteins, which led to decreased levels of amyloid beta in the brain and plasma, which further led to reduced levels of neuroinflammation and improved brain health. This study highlights the importance of autophagy in the simultaneous clearance of amyloid beta and inhibition of NLRP3 inflammasome to ameliorate AD pathology.", "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.7554/elife.111724.1.sa2", "doi": "10.7554/elife.111724.1.sa2", "title": "Reviewer #1 (Public review): Connections across regional glymphatic clearance, neural activity and amyloid-β deposition in cortex", "publicationYear": 2026, "publicationDate": "2026-07-16", "type": "peer-review", "publisher": "eLife Sciences Publications, Ltd", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.7554/elife.111724.1.sa2", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1111/ejn.16332/v1/decision1", "doi": "10.1111/ejn.16332/v1/decision1", "title": "Decision letter for \"ArcheD, a residual neural network for prediction of cerebrospinal fluid amyloid-beta from amyloid PET images\"", "publicationYear": 2023, "publicationDate": "2023-12-17", "type": "peer-review", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1111/ejn.16332/v1/decision1", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1111/ejn.16332/v2/decision1", "doi": "10.1111/ejn.16332/v2/decision1", "title": "Decision letter for \"ArcheD, a residual neural network for prediction of cerebrospinal fluid amyloid-beta from amyloid PET images\"", "publicationYear": 2024, "publicationDate": "2024-03-07", "type": "peer-review", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1111/ejn.16332/v2/decision1", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.15616/bsl.2025.31.3.236", "doi": "10.15616/bsl.2025.31.3.236", "title": "The Neuroprotective Effects of Berberine in Alzheimer’s Disease Mouse Model via Improvement of Mitochondrial Dysfunction and Enhanced Amyloid-beta Peptide Clearance", "publicationYear": 2025, "publicationDate": "2025-09-30", "type": "journal-article", "publisher": "The Korean Society for Biomedical Laboratory Sciences", "containerTitle": "Biomedical Science Letters", "volume": "31", "issue": "3", "page": "236-246", "issn": "2288-7415", "isbn": null, "authors": "Jin-Seok Kim, Hyun-Jeong Cho", "authorCount": 2, "firstAuthorAffiliation": "Department of Biomedical Laboratory Science, College of Medical Science, Konyang University, Daejeon 35365, Korea", "isReferencedByCount": 0, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/3.0/", "funderNames": "National Research Foundation of Korea", "funderIds": "10.13039/501100003725", "url": "https://doi.org/10.15616/bsl.2025.31.3.236", "pdfUrl": "https://pdf.medrang.co.kr/BSL/2025/031/BSL031-03-236.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1101/2024.05.23.595586", "doi": "10.1101/2024.05.23.595586", "title": "Structural and functional analysis of TREM2 interactions with amyloid beta reveal molecular mechanisms that mediate phagocytosis of oligomeric amyloid beta", "publicationYear": 2024, "publicationDate": "2024-05-25", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Jessica A. Greven, Omar Osario, Jay C. Nix, Jennifer M. Alexander-Brett, Tom J. Brett", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/2024.05.23.595586", "pdfUrl": null, "abstract": "Abstract The TREM2 receptor is expressed on microglia in the brain, where it plays critical roles regulating microglia function. TREM2 engages a number of ligands involved in Alzheimer’s disease, and consequent signaling triggers phagocytosis, activation, survival, and proliferation. TREM2 has emerged as a drug target for AD, however very little is known regarding the structural basis for TREM2 microglial functions. Here we investigated the engagement of oligomeric amyloid beta (oAβ42) with TREM2. Using familial variants of amyloid beta, we show that mutations in the N-terminal portion of Aβ, notably residues H6 and D7, disrupt binding to TREM2. We then co-crystallized TREM2 with Aβ(1-8) peptide and determined the high resolution crystal structure. The structure revealed the peptide binds to the hydrophobic site of TREM2, closest to CDR1. Mutational and binding studies using BLI confirmed that mutations to the hydrophobic site ablate binding to oAβ42. Finally, we show that these interactions are critical to triggering phagocytosis of oAβ42, as oAβ42 variants H6R and D7N are not phagocytosed. Altogether, these data indicate that TREM2 engages oAβ42 using the hydrophobic site on TREM2 and the N-terminal portion of Aβ, and that this interaction is critical to trigger signaling and phagocytosis.", "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.3389/fnins.2023.1107436", "doi": "10.3389/fnins.2023.1107436", "title": "Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease", "publicationYear": 2023, "publicationDate": "2023-03-14", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Neuroscience", "volume": "17", "issue": null, "page": null, "issn": "1662-453X", "isbn": null, "authors": "Printha Wijesinghe, Clayton A. Whitmore, Matthew Campbell, Charles Li, Miranda Tsuyuki, Eleanor To, Justin Haynes, Wellington Pham, Joanne A. Matsubara", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 33, "referenceCount": 70, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3389/fnins.2023.1107436", "pdfUrl": null, "abstract": "IntroductionErgothioneine (Ergo) is a naturally occurring dietary antioxidant. Ergo uptake is dependent on the transporter, organic cation transporter novel-type 1 (OCTN1) distribution. OCTN1 is highly expressed in blood cells (myeloid lineage cells), brain and ocular tissues that are likely predisposed to oxidative stress. Ergo may protect the brain and eye against oxidative damage and inflammation, however, the underlying mechanism remains unclear. Amyloid beta (Aβ) clearance is a complex process mediated by various systems and cell types including vascular transport across the blood–brain barrier, glymphatic drainage, and engulfment and degradation by resident microglia and infiltrating innate immune cells. Impaired Aβ clearance is a major cause for Alzheimer’s disease (AD). Here we investigated neuroretinas to explore the neuroprotective effect of Ergo in a transgenic AD mouse model.MethodsAge-matched groups of Ergo-treated 5XFAD, non-treated 5XFAD, and C57BL/6J wildtype (WT controls) were used to assess Ergo transporter OCTN1 expression and Aβ load along with microglia/macrophage (IBA1) and astrocyte (GFAP) markers in wholemount neuroretinas (n = 26) and eye cross-sections (n = 18). Immunoreactivity was quantified by fluorescence or by semi-quantitative assessments.Results and discussionOCTN1 immunoreactivity was significantly low in the eye cross-sections of Ergo-treated and non-treated 5XFAD vs. WT controls. Strong Aβ labeling, detected in the superficial layers in the wholemounts of Ergo-treated 5XFAD vs. non-treated 5XFAD reflects the existence of an effective Aβ clearance system. This was supported by imaging of cross-sections where Aβ immunoreactivity was significantly low in the neuroretina of Ergo-treated 5XFAD vs. non-treated 5XFAD. Moreover, semi-quantitative analysis in wholemounts identified a significantly reduced number of large Aβ deposits or plaques, and a significantly increased number of IBA1(+)ve blood-derived phagocytic macrophages in Ergo-treated 5XFAD vs. non-treated 5XFAD. In sum, enhanced Aβ clearance in Ergo-treated 5XFAD suggests that Ergo uptake may promote Aβ clearance possibly by blood-derived phagocytic macrophages and via perivascular drainage.", "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.3389/fphar.2026.1839516", "doi": "10.3389/fphar.2026.1839516", "title": "Chronic inhibition of receptor protein tyrosine phosphatase β/ζ reduces amyloid plaque load and modulates pleiotrophin-expressing glial cells, glial-plaque interactions and genes related to amyloid beta clearance", "publicationYear": 2026, "publicationDate": "2026-06-19", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Pharmacology", "volume": "17", "issue": null, "page": null, "issn": "1663-9812", "isbn": null, "authors": "Teresa Fontán-Baselga, Héctor Cañeque-Rufo, Elisa Rivera-Illades, Esther Gramage, José María Zapico, Beatriz de Pascual-Teresa, María del Pilar Ramos-Álvarez, Marta Vicente-Rodríguez, Gonzalo Herradón", "authorCount": 9, "firstAuthorAffiliation": "Department of Health and Pharmaceutical Sciences, Faculty of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe", "isReferencedByCount": 0, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3389/fphar.2026.1839516", "pdfUrl": null, "abstract": "Alzheimer’s disease (AD) is the most common cause of dementia. Pleiotrophin (PTN) is a neurotrophic factor relevant for central nervous system repair, neuron differentiation and survival. It is upregulated in different neuroinflammatory conditions. PTN is an endogenous inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ. In a previous study, we showed that a short treatment with the RPTPβ/ζ inhibitor MY10 reduced amyloid beta (Aβ) plaque formation and glial activation in old APP/PS1 mice. Nevertheless, these preliminary data required new studies to prove the disease-modifying potential of RPTPβ/ζ inhibition by using younger animals and a longer treatment with MY10. Thus, we have now treated for 3 months five- to seven-month-old wild type (WT) and APP/PS1 mice with MY10. This treatment decreased Aβ plaque formation and increased the number of microglial cells in the dorsal subiculum of APP/PS1 mice. In addition, MY10 reduced the number of GFAP+, not Iba1+, cells surrounding Aβ plaques. As expected, PTN expression was upregulated in the brain of APP/PS1 compared to WT mice and it was mainly found in Iba1+ and GFAP+ cells. Interestingly, treatment with MY10 significantly decreased the expression of PTN and the number of PTN-expressing Iba1+ and GFAP+ cells. MY10 induced a significant decrease of Mmp9 expression in the hippocampus of APP/PS1 mice, a key enzyme in AD progression. In summary, chronic inhibition of RPTPβ/ζ in APP/PS1 mice reduces Aβ plaque deposition, modulating glial-plaque interactions and the expression of specific genes including Ptn and its receptor.", "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1016/j.ibneur.2023.08.913", "doi": "10.1016/j.ibneur.2023.08.913", "title": "SAMHWANG-SASIM DECOCTION ATTENUATES COGNITIVE DECLINE AND NEURONAL CELL DEATH THROUGH AMYLOID-BETA CLEARANCE AND BDNF SIGNALING IN ALZHEIMER’S DISEASE MOUSE MODELS", "publicationYear": 2023, "publicationDate": "2023-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "IBRO Neuroscience Reports", "volume": "15", "issue": null, "page": "S470", "issn": "2667-2421", "isbn": null, "authors": "Malk Eun Pak, Yeo Jin Park, Buyun Kim, Hye Jin Yang, Wei Li, Younghoon Go", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.ibneur.2023.08.913", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.17504/protocols.io.j8nlk8ky1l5r/v1", "doi": "10.17504/protocols.io.j8nlk8ky1l5r/v1", "title": "Protein Extraction for Amyloid Beta Fractionation v1", "publicationYear": 2024, "publicationDate": "2024-05-08", "type": "posted-content", "publisher": "ZappyLab, Inc.", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Lisa Blackmer-Raynolds, Tim Sampson", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.17504/protocols.io.j8nlk8ky1l5r/v1", "pdfUrl": null, "abstract": "This protocol can be used to isolate protein from murine brain tissue (volumes listed are for hippocampal samples) by solubility. It creates three protein fractions: tris soluble, triton soluble, and formic acid soluble. This protocol can be helpful when evaluating amyloid beta pathology as different amyloid beta structures can be found within each fraction. For example, insoluble amyloid beta associated with amyloid plaques will be found within the formic acid soluble fraction, whereas more soluble non-plaque associated amyloid beta will be found within the other two fractions.", "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1002/cne.25679/v2/review2", "doi": "10.1002/cne.25679/v2/review2", "title": "Review for \"Amyloid‐Beta, Tau, and Microglial Activation in Aged Felid Brains\"", "publicationYear": 2024, "publicationDate": "2024-09-21", "type": "peer-review", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/cne.25679/v2/review2", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "fiVOrfRRn52zVCBdw", "_dataset_id": "b9x3rvZTp8aLHbWyS"}
{"paperId": "10.1109/iciip68302.2025.11346348", "doi": "10.1109/iciip68302.2025.11346348", "title": "Speech-to-Image Generation Using Audio Embeddings and Latent Diffusion Models", "publicationYear": 2025, "publicationDate": "2025-11-27", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 Eighth International Conference on Image Information Processing (ICIIP)", "volume": null, "issue": null, "page": "793-799", "issn": null, "isbn": null, "authors": "Chandan Rani S R, N P Kavya", "authorCount": 2, "firstAuthorAffiliation": "Visvesvaraya Technological University,Department of CS&#x0026;E RNS Institute of Technology,Bangalore,India", "isReferencedByCount": 0, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/iciip68302.2025.11346348", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "XIxrTQL3H6jKmydBt", "_dataset_id": "wX7cAUINab8tz5cV8"}
{"paperId": "10.1109/gcwkshps68340.2025.11591056", "doi": "10.1109/gcwkshps68340.2025.11591056", "title": "High-resolution efficient image generation from WiFi CSI using a pretrained latent diffusion model", "publicationYear": 2025, "publicationDate": "2025-12-08", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 IEEE Globecom Workshops (GC Wkshps)", "volume": null, "issue": null, "page": "709-714", "issn": null, "isbn": null, "authors": "Eshan Ramesh, Takayuki Nishio", "authorCount": 2, "firstAuthorAffiliation": "Institute of Science Tokyo,School of Engineering", "isReferencedByCount": 0, "referenceCount": 13, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/gcwkshps68340.2025.11591056", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "XIxrTQL3H6jKmydBt", "_dataset_id": "wX7cAUINab8tz5cV8"}
{"paperId": "10.1109/icaace69793.2026.11508827", "doi": "10.1109/icaace69793.2026.11508827", "title": "Controllability and Structural Stability in Latent Diffusion Image Generation", "publicationYear": 2026, "publicationDate": "2026-03-20", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2026 9th International Conference on Advanced Algorithms and Control Engineering (ICAACE)", "volume": null, "issue": null, "page": "990-995", "issn": null, "isbn": null, "authors": "Shaoyi Guo, Yinan Xu", "authorCount": 2, "firstAuthorAffiliation": "Shenyang Jianzhu University,Department of Artistic Design,Shenyang,China", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/icaace69793.2026.11508827", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "XIxrTQL3H6jKmydBt", "_dataset_id": "wX7cAUINab8tz5cV8"}
{"paperId": "10.1117/12.3046462", "doi": "10.1117/12.3046462", "title": "CT cardiac image and label generation by a 3D latent diffusion model", "publicationYear": 2025, "publicationDate": "2025-04-11", "type": "proceedings-article", "publisher": "SPIE", "containerTitle": "Medical Imaging 2025: Image Processing", "volume": null, "issue": null, "page": "51", "issn": null, "isbn": null, "authors": "Ashok Vardhan Addala, Quanqi Hu, Masaki Ikuta, Ravi Soni, Gopal Avinash", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 10, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1117/12.3046462", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "XIxrTQL3H6jKmydBt", "_dataset_id": "wX7cAUINab8tz5cV8"}
{"paperId": "10.1109/icip55913.2025.11084366", "doi": "10.1109/icip55913.2025.11084366", "title": "Efficient Atlas Generation for Medical Imaging Via Groupwise Latent Diffusion Models", "publicationYear": 2025, "publicationDate": "2025-09-14", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 IEEE International Conference on Image Processing (ICIP)", "volume": null, "issue": null, "page": "2534-2539", "issn": null, "isbn": null, "authors": "Ziyi He, Albert C. S. Chung", "authorCount": 2, "firstAuthorAffiliation": "The Hong Kong University of Science and Technology,Department of Computer Science and Engineering", "isReferencedByCount": 0, "referenceCount": 18, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/icip55913.2025.11084366", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "XIxrTQL3H6jKmydBt", "_dataset_id": "wX7cAUINab8tz5cV8"}
{"paperId": "10.1117/12.3038549", "doi": "10.1117/12.3038549", "title": "LSGDM: shadow generation for composite image with latent diffusion model", "publicationYear": 2024, "publicationDate": "2024-08-23", "type": "proceedings-article", "publisher": "SPIE", "containerTitle": "Fourth International Conference on Image Processing and Intelligent Control (IPIC 2024)", "volume": null, "issue": null, "page": "69", "issn": null, "isbn": null, "authors": "Yong Lu, Guangxi Chen, Xiaolin Xiang", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1117/12.3038549", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "XIxrTQL3H6jKmydBt", "_dataset_id": "wX7cAUINab8tz5cV8"}
{"paperId": "10.1109/isriti56927.2022.10052908", "doi": "10.1109/isriti56927.2022.10052908", "title": "Text to Image Latent Diffusion Model with Dreambooth Fine Tuning for Automobile Image Generation", "publicationYear": 2022, "publicationDate": "2022-12-08", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2022 5th International Seminar on Research of Information Technology and Intelligent Systems (ISRITI)", "volume": null, "issue": null, "page": "440-445", "issn": null, "isbn": null, "authors": "Muhammad Fariz Sutedy, Nunung Nurul Qomariyah", "authorCount": 2, "firstAuthorAffiliation": "School of Computing and Creative Arts, Bina Nusantara University,Computer Science Department,Jakarta,Indonesia,11480", "isReferencedByCount": 5, "referenceCount": 17, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/isriti56927.2022.10052908", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "XIxrTQL3H6jKmydBt", "_dataset_id": "wX7cAUINab8tz5cV8"}
{"paperId": "10.1109/qce65121.2025.10364", "doi": "10.1109/qce65121.2025.10364", "title": "Hybrid Quantum-Classical Latent Diffusion Models for Medical Image Generation", "publicationYear": 2025, "publicationDate": "2025-08-30", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 IEEE International Conference on Quantum Computing and Engineering (QCE)", "volume": null, "issue": null, "page": "398-399", "issn": null, "isbn": null, "authors": "Nora Bauer, Kübra Yeter-Aydeniz, Max Masnick", "authorCount": 3, "firstAuthorAffiliation": "The MITRE Corporation,Quantum Information Sciences, Optics and Imaging Department,McLean,USA", "isReferencedByCount": 0, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/qce65121.2025.10364", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "XIxrTQL3H6jKmydBt", "_dataset_id": "wX7cAUINab8tz5cV8"}
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{"paperId": "10.1021/jacs.5c14935", "doi": "10.1021/jacs.5c14935", "title": "Spin-State and Reorganization Energy Considerations for Metal-Centered Photoredox Catalysis", "publicationYear": 2025, "publicationDate": "2025-10-29", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "147", "issue": "43", "page": "39898-39911", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Bekah E. Bowers, Björn Pfund, Hayden F. Beissel, Atanu Ghosh, James K. McCusker", "authorCount": 5, "firstAuthorAffiliation": "Contribution from the Department of Chemistry, Michigan State University, 578 South Shaw Lane, East Lansing, Michigan 48824, United States", "isReferencedByCount": 14, "referenceCount": 110, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Basic Energy Sciences", "funderIds": "10.13039/100006151", "url": "https://doi.org/10.1021/jacs.5c14935", "pdfUrl": "https://pubs.acs.org/doi/pdf/10.1021/jacs.5c14935", "abstract": null, "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1021/ja309580a", "doi": "10.1021/ja309580a", "title": "Oxygen Switch in Visible-Light Photoredox Catalysis: Radical Additions and Cyclizations and Unexpected C–C-Bond Cleavage Reactions", "publicationYear": 2013, "publicationDate": "2013-02-06", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "135", "issue": "5", "page": "1823-1829", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Shaoqun Zhu, Arindam Das, Lan Bui, Hanjun Zhou, Dennis P. Curran, Magnus Rueping", "authorCount": 6, "firstAuthorAffiliation": "RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, D-52074 Aachen, Germany", "isReferencedByCount": 407, "referenceCount": 113, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/ja309580a", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1021/jacs.1c01083", "doi": "10.1021/jacs.1c01083", "title": "Bifunctional Metal–Organic Layer with Organic Dyes and Iron Centers for Synergistic Photoredox Catalysis", "publicationYear": 2021, "publicationDate": "2021-03-03", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "143", "issue": "8", "page": "3075-3080", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Yangjian Quan, Wenjie Shi, Yang Song, Xiaomin Jiang, Cheng Wang, Wenbin Lin", "authorCount": 6, "firstAuthorAffiliation": "Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States", "isReferencedByCount": 106, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": "University of Chicago, National Science Foundation", "funderIds": "10.13039/100007234, 10.13039/100000001", "url": "https://doi.org/10.1021/jacs.1c01083", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1021/jacs.3c02832", "doi": "10.1021/jacs.3c02832", "title": "Two-Photon Excitation Photoredox Catalysis Enabled Atom Transfer Radical Polymerization", "publicationYear": 2023, "publicationDate": "2023-06-14", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "145", "issue": "23", "page": "12737-12744", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Yu-Ying Yang, Pengfei Zhang, Nikos Hadjichristidis", "authorCount": 3, "firstAuthorAffiliation": "Polymer Synthesis Laboratory, Chemistry Program, KAUST Catalysis Center, Physical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955, Saudi Arabia", "isReferencedByCount": 38, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "King Abdullah University of Science and Technology", "funderIds": "10.13039/501100004052", "url": "https://doi.org/10.1021/jacs.3c02832", "pdfUrl": "https://pubs.acs.org/doi/pdf/10.1021/jacs.3c02832", "abstract": null, "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1021/jacs.2c08039", "doi": "10.1021/jacs.2c08039", "title": "Remote and Proximal Hydroaminoalkylation of Alkenes Enabled by Photoredox/Nickel Dual Catalysis", "publicationYear": 2022, "publicationDate": "2022-10-05", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "144", "issue": "39", "page": "17776-17782", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Songlin Zheng, Wenlong Wang, Weiming Yuan", "authorCount": 3, "firstAuthorAffiliation": "Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), 1037 Luoyu Road, Wuhan 430074, China", "isReferencedByCount": 88, "referenceCount": 47, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": "Guangdong Science and Technology Department, Guangdong Science and Technology Department, Guangdong Provincial Key Laboratory Of Catalysis, Central University Basic Research Fund of China, Huazhong University of Science and Technology", "funderIds": "10.13039/501100007162, 10.13039/501100007162, 10.13039/501100021174, 10.13039/501100018594, 10.13039/501100003397", "url": "https://doi.org/10.1021/jacs.2c08039", "pdfUrl": "https://pubs.acs.org/doi/pdf/10.1021/jacs.2c08039", "abstract": null, "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1021/jacs.6b05934", "doi": "10.1021/jacs.6b05934", "title": "A Luminescent Zirconium(IV) Complex as a Molecular Photosensitizer for Visible Light Photoredox Catalysis", "publicationYear": 2016, "publicationDate": "2016-10-12", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "138", "issue": "40", "page": "13115-13118", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Yu Zhang, Jeffrey L. Petersen, Carsten Milsmann", "authorCount": 3, "firstAuthorAffiliation": "C. Eugene\rBennett Department\rof Chemistry, West Virginia University, 100 Prospect Street, Morgantown, West Virginia 26506, United States", "isReferencedByCount": 179, "referenceCount": 52, "isOpenAccess": true, "licenseUrl": null, "funderNames": "West Virginia University, Don and Linda Brodie Resource Fund for Innovation", "funderIds": "10.13039/100009455", "url": "https://doi.org/10.1021/jacs.6b05934", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1021/jacs.7b08086", "doi": "10.1021/jacs.7b08086", "title": "Intermolecular Radical Addition to Carbonyls Enabled by Visible Light Photoredox Initiated Hole Catalysis", "publicationYear": 2017, "publicationDate": "2017-10-04", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "139", "issue": "39", "page": "13652-13655", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Lena Pitzer, Frederik Sandfort, Felix Strieth-Kalthoff, Frank Glorius", "authorCount": 4, "firstAuthorAffiliation": "Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster, Germany", "isReferencedByCount": 142, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": null, "funderNames": "Alfried Krupp von Bohlen und Halbach-Stiftung, Deutsche Forschungsgemeinschaft", "funderIds": "10.13039/501100005306, 10.13039/501100001659", "url": "https://doi.org/10.1021/jacs.7b08086", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1021/jacs.8b08052", "doi": "10.1021/jacs.8b08052", "title": "Diastereoselective Allylation of Aldehydes by Dual Photoredox and Chromium Catalysis", "publicationYear": 2018, "publicationDate": "2018-10-10", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "140", "issue": "40", "page": "12705-12709", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "J. Luca Schwarz, Felix Schäfers, Adrian Tlahuext-Aca, Lukas Lückemeier, Frank Glorius", "authorCount": 5, "firstAuthorAffiliation": "Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster, Germany", "isReferencedByCount": 251, "referenceCount": 79, "isOpenAccess": true, "licenseUrl": null, "funderNames": "Deutsche Forschungsgemeinschaft, Alfried Krupp von Bohlen and Halbach-Stiftung", "funderIds": "10.13039/501100001659", "url": "https://doi.org/10.1021/jacs.8b08052", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1021/ja511913h", "doi": "10.1021/ja511913h", "title": "Merging Photoredox and Nickel Catalysis: Decarboxylative Cross-Coupling of Carboxylic Acids with Vinyl Halides", "publicationYear": 2015, "publicationDate": "2015-01-21", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "137", "issue": "2", "page": "624-627", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Adam Noble, Stefan J. McCarver, David W. C. MacMillan", "authorCount": 3, "firstAuthorAffiliation": "Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States", "isReferencedByCount": 442, "referenceCount": 53, "isOpenAccess": true, "licenseUrl": "http://pubs.acs.org/page/policy/authorchoice_termsofuse.html", "funderNames": "National Institute of General Medical Sciences", "funderIds": "10.13039/100000057", "url": "https://doi.org/10.1021/ja511913h", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1021/ja406311g", "doi": "10.1021/ja406311g", "title": "Mechanistic Insights and Kinetic Analysis for the Oxidative Hydroxylation of Arylboronic Acids by Visible Light Photoredox Catalysis: A Metal-Free Alternative", "publicationYear": 2013, "publicationDate": "2013-09-11", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "135", "issue": "36", "page": "13286-13289", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Spencer P. Pitre, Christopher D. McTiernan, Hossein Ismaili, Juan C. Scaiano", "authorCount": 4, "firstAuthorAffiliation": "Department of Chemistry and Centre\rfor Catalysis Research\rand Innovation, University of Ottawa, 10\rMarie Curie, Ottawa K1N 6N5, Canada", "isReferencedByCount": 279, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/ja406311g", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1021/jacs.1c11667", "doi": "10.1021/jacs.1c11667", "title": "High Triplet Energy Iridium(III) Isocyanoborato Complex for Photochemical Upconversion, Photoredox and Energy Transfer Catalysis", "publicationYear": 2022, "publicationDate": "2022-01-19", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "144", "issue": "2", "page": "963-976", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Lucius Schmid, Felix Glaser, Raoul Schaer, Oliver S. Wenger", "authorCount": 4, "firstAuthorAffiliation": "Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland", "isReferencedByCount": 96, "referenceCount": 173, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung", "funderIds": "10.13039/501100001711", "url": "https://doi.org/10.1021/jacs.1c11667", "pdfUrl": "https://pubs.acs.org/doi/pdf/10.1021/jacs.1c11667", "abstract": null, "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1039/c6cc04636c", "doi": "10.1039/c6cc04636c", "title": "Organic photoredox catalysis for the oxidation of silicates: applications in radical synthesis and dual catalysis", "publicationYear": 2016, "publicationDate": "2016", "type": "journal-article", "publisher": "Royal Society of Chemistry (RSC)", "containerTitle": "Chemical Communications", "volume": "52", "issue": "64", "page": "9877-9880", "issn": "1359-7345, 1364-548X", "isbn": null, "authors": "Christophe Lévêque, Ludwig Chenneberg, Vincent Corcé, Cyril Ollivier, Louis Fensterbank", "authorCount": 5, "firstAuthorAffiliation": "Institut Parisien de Chimie Moléculaire", "isReferencedByCount": 92, "referenceCount": 52, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1039/c6cc04636c", "pdfUrl": null, "abstract": "Metal free photooxidation of alkyl bis(catecholato)silicates with the organic dye 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyano-benzene (4CzIPN) allows the smooth formation of alkyl radicals.", "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1021/jacs.0c06976", "doi": "10.1021/jacs.0c06976", "title": "Highly Effective Near-Infrared Activating Triplet–Triplet Annihilation Upconversion for Photoredox Catalysis", "publicationYear": 2020, "publicationDate": "2020-10-28", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "142", "issue": "43", "page": "18460-18470", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Ling Huang, Wenting Wu, Yang Li, Kai Huang, Le Zeng, Wenhai Lin, Gang Han", "authorCount": 7, "firstAuthorAffiliation": "Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States", "isReferencedByCount": 174, "referenceCount": 79, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": "University of Massachusetts Medical School", "funderIds": "10.13039/100007920", "url": "https://doi.org/10.1021/jacs.0c06976", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YFrCvFQl2vLp8jIog", "_dataset_id": "7GxQIgm1gmUcWhrlo"}
{"paperId": "10.1093/oncolo/oyag155", "doi": "10.1093/oncolo/oyag155", "title": "KRAS G12R in pancreatic cancer: why this mutation resists current inhibitor strategies", "publicationYear": 2026, "publicationDate": "2026-06-06", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "The Oncologist", "volume": "31", "issue": "7", "page": null, "issn": "1083-7159, 1549-490X", "isbn": null, "authors": "Kenneth A Kern", "authorCount": 1, "firstAuthorAffiliation": "Affiliate Faculty, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , San Diego, CA 92109,", "isReferencedByCount": 0, "referenceCount": 48, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/oncolo/oyag155", "pdfUrl": "https://academic.oup.com/oncolo/advance-article-pdf/doi/10.1093/oncolo/oyag155/68446122/oyag155.pdf", "abstract": "Abstract Background Pancreatic ductal adenocarcinoma (PDAC) remains among the most lethal solid malignancies, with limited therapeutic progress despite decades of cytotoxic chemotherapy. About 90% of PDAC tumors harbor activating mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS), making oncogenic KRAS signaling a longstanding therapeutic target. Although KRAS G12C inhibitors have demonstrated clinical success in lung and colorectal cancers, this strategy has not translated to the same degree in the glycine-to-arginine substitution at codon 12 (G12R), present in 15%-20% of PDAC tumors. Methods A focused narrative review of the literature was conducted using PubMed and Google Scholar to examine structural, biochemical, and clinical data relevant to KRAS G12R, binding pocket dynamics, therapeutic outcomes, and novel approaches. Results G12R substitution introduces a bulky, positively charged arginine side chain that sterically occludes the binding pocket of KRAS (Switch II pocket), precluding both covalent and competitive inhibitor engagement. In addition to structural inaccessibility, G12R mutations exhibit distinct signaling rewiring, including impaired phosphoinositide 3-kinase alpha (PI3Kα) and mitogen-activated protein kinase (MEK) interactions, along with increased survival driven by amplified autophagy. These features limit the efficacy of pocket-directed inhibitors and downstream MEK blockade. Emerging pan-RAS(ON) ternary complex inhibitors bypass the occluded pocket by recruiting cyclophilin A to block effector signaling and may provide an effective means to address KRAS G12R-mutated disease. Conclusions KRAS G12R defines a structurally and biologically distinct subset of PDAC characterized by binding-pocket occlusion and increased survival pathways. Effective treatment will require pocket-independent strategies or targeting of G12R-specific biological vulnerabilities.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1535-7163.targ-15-b90", "doi": "10.1158/1535-7163.targ-15-b90", "title": "Abstract B90: HSP90 inhibitor NVP-AUY922 sensitizes intrinsic MEK inhibitor Trametinib-resistant NSCLC cells harboring KRAS mutation", "publicationYear": 2015, "publicationDate": "2015-12-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Molecular Cancer Therapeutics", "volume": "14", "issue": "12_Supplement_2", "page": "B90-B90", "issn": "1535-7163, 1538-8514", "isbn": null, "authors": "Dae Ho Lee, Kang-Seo Park, Bora Oh, Mi-Hee Lee, Hannah Yang", "authorCount": 5, "firstAuthorAffiliation": "1Univ. of Ulsan Asan Medical Ctr., Seoul, Korea, Republic of;", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1535-7163.targ-15-b90", "pdfUrl": "https://aacrjournals.org/mct/article/14/12_Supplement_2/B90/232668/Abstract-B90-HSP90-inhibitor-NVP-AUY922-sensitizes", "abstract": "Abstract Introduction: Mutant KRAS is feature of more than 25% of non-small cell lung cancers (NSCLC) and exemplifies one of the most popular oncogenic drivers. Ras-driven tumors are often hard to cure with conventional therapies and are necessary novel treatment strategies. Experiment: Using the HSP90 inhibitor NVP-AUY922, we investigated the potential of HSP90 inhibition to overcome the resistance to Trametinib, MEK inhibitor, in lung cancers harboring K-RAS mutant cell lines (H23, H358, H647, H1944, and A549). The synergistic effect of AUY-922 and trametinib was determined by analysis of the combination index (CI). After performing western blotting, we underwent following xenograft study with 6-week-old Balb/c-nu/nu female using H649 and H1944 cell lines. The mice were randomized into groups of 5, and NVP-AUY922 (5 mg/kg) was administered 3 days/week and GSK1120212 (300 μg/kg) was administered 5 days/week for up to 21 days in total. Result: NSCLC cells harboring G13D KRAS mutation showed intrinsic MEK inhibitor resistance via PI3K activation by highly expressed AKT as a bypass pathway. And then, HSP90 inhibitor AUY-922 suppresses both PI3K-AKT-mTOR and RAF-MEK-ERK reactivated by MEK inhibitor GSK1120212 and finally AUY-922 renders intrinsic MEK inhibitor resistant NSCLC cells sensitive to GSK1120212 with significant synergy. Furthermore, we showed this synergistic effect is occurred on sub-effective dose of either drug. Conclusion: The dual inhibition of HSP90 and MEK signaling pathways on sub-effective dose may constitute a potent therapeutic strategy to treat intrinsic MEK inhibitor resistant G13DKRAS mutant NSCLCs for resolving toxicity problem of dual inhibition of AKT and MEK in clinical trials. Citation Format: Dae Ho Lee, Kang-Seo Park, Bora Oh, Mi-Hee Lee, Hannah Yang. HSP90 inhibitor NVP-AUY922 sensitizes intrinsic MEK inhibitor Trametinib-resistant NSCLC cells harboring KRAS mutation. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B90.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.2174/0929867329666220907161505", "doi": "10.2174/0929867329666220907161505", "title": "Sotorasib: First Approved <i>KRAS</i> Mutation Inhibitor for the Treatment of Non-small Cell Lung Cancer", "publicationYear": 2023, "publicationDate": "2023-03", "type": "journal-article", "publisher": "Bentham Science Publishers Ltd.", "containerTitle": "Current Medicinal Chemistry", "volume": "30", "issue": "9", "page": "1000-1002", "issn": "0929-8673", "isbn": null, "authors": "Surya K. De", "authorCount": 1, "firstAuthorAffiliation": "Conju-probe, San Diego, California, USA", "isReferencedByCount": 5, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2174/0929867329666220907161505", "pdfUrl": "https://www.eurekaselect.com/article/download?doi=10.2174/0929867329666220907161505", "abstract": "", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/2159-8290.cd-rw2023-090", "doi": "10.1158/2159-8290.cd-rw2023-090", "title": "A Pan-KRAS Inhibitor Impedes Common KRAS Oncoproteins and Tumor Growth", "publicationYear": 2023, "publicationDate": "2023-08-04", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Discovery", "volume": "13", "issue": "8", "page": "1757-1757", "issn": "2159-8274, 2159-8290", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/2159-8290.cd-rw2023-090", "pdfUrl": "https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-RW2023-090/727234/A-Pan-KRAS-Inhibitor-Impedes-Common-KRAS", "abstract": "Abstract A pan-KRAS inhibitor is selec­tive for the inactive state of multiple KRAS mutants, sparing other RAS isoforms.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1093/ajcp/aqaf121.447", "doi": "10.1093/ajcp/aqaf121.447", "title": "20 Beyond KRAS G12D Mutation: The Prognostic Significance of The KRAS Mutation Variants on Progression-Free Survival in Pancreatic Ductal Adenocarcinoma", "publicationYear": 2025, "publicationDate": "2025-11-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "American Journal of Clinical Pathology", "volume": "164", "issue": "Supplement_1", "page": null, "issn": "0002-9173, 1943-7722", "isbn": null, "authors": "Ahmed Younes, Haider Mejbel", "authorCount": 2, "firstAuthorAffiliation": "Emory University School of Medicine", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/ajcp/aqaf121.447", "pdfUrl": "https://academic.oup.com/ajcp/article-pdf/164/Supplement_1/aqaf121.447/65271120/aqaf121.447.pdf", "abstract": "Abstract Pancreatic ductal adenocarcinomas (PDACs) are aggressive neoplasms with poor outcomes. The prognostic significance of major driver gene mutation, beyond KRAS G12D, is yet to be explored. A 10-year retrospective comprehensive study of the prognostic significance of major driver genes in PDACs was conducted. Next-generation sequencing was performed on 131 PDACs. The highest mutation rates observed were in KRAS (n = 121; 92.4%), followed by TP53 (n = 92; 70.2%), SMAD4 (n = 38; 29%), and CDKN2A (n = 30; 22.9%). Among KRAS-mutated PDACs that underwent neoadjuvant chemotherapy (n = 96; 73.3%), the presence of SMAD4 and/or TP53 mutations was associated with worse progression-free survival (PFS). Patients with KRAS G12V mutations exhibited a trend where those with SMAD4/TP53 wild-type had better PFS compared to those with the mutated SMAD4/TP53, particularly during the early months of follow-up. KRAS G12R mutations showed the most distinct separation pattern in PFS, with SMAD4/TP53 wild-type PDACs showing relatively better PFS. In contrast, KRAS G12D had a more uniform effect on disease progression, regardless of SMAD4 and TP53 mutation status. Our study shows that the prognostic impact of SMAD4 and TP53 mutations in PDACs may vary depending on the specific KRAS variants. The presence of SMAD4/TP53 mutations was generally associated with poorer survival outcomes in KRAS-mutated cases receiving neoadjuvant chemotherapy, especially among those with the KRAS G12R mutation. Patients with KRAS G12V and G12R mutations had better PFS when SMAD4/TP53 were wild-type, while the impact of KRAS G12D mutations on PFS remained consistent regardless of SMAD4/TP53 mutation status.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1111/joim.13057", "doi": "10.1111/joim.13057", "title": "Targeting Kras<sup>g12c</sup>‐mutant cancer with a mutation‐specific inhibitor", "publicationYear": 2020, "publicationDate": "2020-08", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Journal of Internal Medicine", "volume": "288", "issue": "2", "page": "183-191", "issn": "0954-6820, 1365-2796", "isbn": null, "authors": "J. G. Christensen, P. Olson, T. Briere, C. Wiel, M. O. Bergo", "authorCount": 5, "firstAuthorAffiliation": "From the Mirati Therapeutics, Inc. San Diego CA USA", "isReferencedByCount": 69, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1111/joim.13057", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjoim.13057", "abstract": "AbstractThe RAS genes, which include H, N, and KRAS, comprise the most frequently mutated family of oncogenes in cancer. Mutations in KRAS – such as the G12C mutation – are found in most pancreatic, half of colorectal and a third of lung cancer cases and is thus responsible for a substantial proportion of cancer deaths. Consequently, KRAS has been the subject of exhaustive drug‐targeting efforts over the past 3–4 decades. These efforts have included targeting the KRAS protein itself but also its posttranslational modifications, membrane localization, protein–protein interactions and downstream signalling pathways. Most of these strategies have failed and no KRAS‐specific drugs have yet been approved. However, for one specific mutation, KRASG12C, there is light on the horizon. MRTX849 was recently identified as a potent, selective and covalent KRASG12C inhibitor that possesses favourable drug‐like properties. MRTX849 selectively modifies the mutant cysteine residue in GDP‐bound KRASG12C and inhibits GTP‐loading and downstream KRAS‐dependent signalling. The drug inhibits the in vivo growth of multiple KRASG12C‐mutant cell line xenografts, causes tumour regression in patient‐derived xenograft models and shows striking responses in combination with other agents. It has also produced objective responses in patients with mutant‐specific lung and colorectal cancer. In this review, we discuss the history of RAS drug‐targeting efforts, the discovery of MRTX849, and how this drug provides an exciting and long‐awaited opportunity to selectively target mutant KRAS in patients.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1007/s00280-023-04545-4", "doi": "10.1007/s00280-023-04545-4", "title": "A phase I trial of the pan-ERBB inhibitor neratinib combined with the MEK inhibitor trametinib in patients with advanced cancer with EGFR mutation/amplification, HER2 mutation/amplification, HER3/4 mutation or KRAS mutation", "publicationYear": 2023, "publicationDate": "2023-08", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Cancer Chemotherapy and Pharmacology", "volume": "92", "issue": "2", "page": "107-118", "issn": "0344-5704, 1432-0843", "isbn": null, "authors": "Sarina A. Piha-Paul, Chieh Tseng, Hai T. Tran, Meng Gao, Daniel D. Karp, Vivek Subbiah, Apostolia Maria Tsimberidou, Jitesh D. Kawedia, Siqing Fu, Shubham Pant, Timothy A. Yap, Van K. Morris, Bryan K. Kee, Mariela Blum Murphy, JoAnn Lim, Funda Meric-Bernstam", "authorCount": 16, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "Puma Biotechnology", "funderIds": "10.13039/100019402", "url": "https://doi.org/10.1007/s00280-023-04545-4", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s00280-023-04545-4.pdf", "abstract": "Abstract Purpose Aberrant alterations of ERBB receptor tyrosine kinases lead to tumorigenesis. Single agent therapy targeting EGFR or HER2 has shown clinical successes, but drug resistance often develops due to aberrant or compensatory mechanisms. Herein, we sought to determine the feasibility and safety of neratinib and trametinib in patients with EGFR mutation/amplification, HER2 mutation/amplification, HER3/4 mutation and KRAS mutation. Methods Patients with actionable somatic mutations or amplifications in ERBB genes or actionable KRAS mutations were enrolled to receive neratinib and trametinib in this phase I dose escalation trial. The primary endpoint was determination of the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT). Secondary endpoints included pharmacokinetic analysis and preliminary anti-tumor efficacy. Results Twenty patients were enrolled with a median age of 50.5 years and a median of 3 lines of prior therapy. Grade 3 treatment-related toxicities included: diarrhea (25%), vomiting (10%), nausea (5%), fatigue (5%) and malaise (5%). The MTD was dose level (DL) minus 1 (neratinib 160 mg daily with trametinib 1 mg, 5 days on and 2 days off) given 2 DLTs of grade 3 diarrhea in DL1 (neratinib 160 mg daily with trametinib 1 mg daily). The treatment-related toxicities of DL1 included: diarrhea (100%), nausea (55.6%) and rash (55.6%). Pharmacokinetic data showed trametinib clearance was significantly reduced leading to high drug exposures of trametinib. Two patients achieved stable disease (SD) ≥ 4 months. Conclusion Neratinib and trametinib combination was toxic and had limited clinical efficacy. This may be due to suboptimal drug dosing given drug–drug interactions. Trial registration ID: NCT03065387.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.c.7429504", "doi": "10.1158/1078-0432.c.7429504", "title": "Data from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.c.7429504", "pdfUrl": null, "abstract": "&lt;div&gt;AbstractPurpose:&lt;p&gt;To inform prognosis, treatment response, disease biology, and &lt;i&gt;KRAS G12C&lt;/i&gt; mutation heterogeneity, we conducted exploratory circulating tumor DNA (ctDNA) profiling on 134 patients with solid tumors harboring a &lt;i&gt;KRAS G12C&lt;/i&gt; mutation treated with single-agent divarasib (GDC-6036) in a phase 1 study.&lt;/p&gt;Experimental Design:&lt;p&gt;Plasma samples were collected for serial ctDNA profiling at baseline (cycle 1 day 1 prior to treatment) and multiple on-treatment time points (cycle 1 day 15 and cycle 3 day 1).&lt;/p&gt;Results:&lt;p&gt;&lt;i&gt;KRAS G12C&lt;/i&gt; ctDNA was detectable from plasma samples in 72.9% (43/59) and 92.6% (50/54) of patients with non–small cell lung cancer and colorectal cancer, respectively, the majority of whom were eligible for study participation based on a local test detecting the &lt;i&gt;KRAS G12C&lt;/i&gt; mutation in tumor tissue. Baseline ctDNA tumor fraction was associated with tumor type, disease burden, and metastatic sites. A decline in ctDNA level was observed as early as cycle 1 day 15. Serial assessment showed a decline in ctDNA tumor fraction associated with response and progression-free survival. Except for a few cases of &lt;i&gt;KRAS G12C&lt;/i&gt; sub-clonality, on-treatment changes in &lt;i&gt;KRAS G12C&lt;/i&gt; variant allele frequency mirrored changes in the overall ctDNA tumor fraction.&lt;/p&gt;Conclusions:&lt;p&gt;Across tumor types, the &lt;i&gt;KRAS G12C&lt;/i&gt; mutation likely represents a truncal mutation in the majority of patients. Rapid and deep decline in ctDNA tumor fraction was observed in patients responding to divarasib treatment. Early on-treatment dynamics of ctDNA were associated with patient outcomes and tumor response to divarasib treatment.&lt;/p&gt;&lt;/div&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1535-7163.targ-09-c108", "doi": "10.1158/1535-7163.targ-09-c108", "title": "Abstract C108: A novel mitotic kinesin Eg5 inhibitor exerts the growth-inhibitory effect in cancer cells in a manner independent of induction of monoastral formation but dependent of KRAS mutation status", "publicationYear": 2009, "publicationDate": "2009-12-10", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Molecular Cancer Therapeutics", "volume": "8", "issue": "12_Supplement", "page": "C108-C108", "issn": "1535-7163, 1538-8514", "isbn": null, "authors": "Toshimitsu Tanaka", "authorCount": 1, "firstAuthorAffiliation": "Shizuoka Cancer Center Research Institute, Suntou-gun, Japan.", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1535-7163.targ-09-c108", "pdfUrl": "https://aacrjournals.org/mct/article/8/12_Supplement/C108/237744/Abstract-C108-A-novel-mitotic-kinesin-Eg5", "abstract": "Abstract Mitotic kinesin Eg5 plays an important role in mitosis, as it is critical for proper bipolar spindle assembly. After the discovery of the first Eg5 inhibitor monastrol, a number of Eg5 inhibitors have been developed as anticancer drugs. We have previously synthesized a series of S-trityl-L-cysteine (STLC) derivatives as Eg5 inhibitors and demonstrated potent inhibitory effect on Eg5 ATPase activity and induction of mitotic arrest with characteristic monoastral spindles in HeLa cells. In this study, we evaluated the growth-inhibitory acitivities of novel STLC derivatives, Compound1, Compound2, and Compound3 by MTT assay in a wide range of human cancer cell lines derived from gastric (MKN1, MKN45, MKN74, NUGC3, NUGC4, NCI-N87), colon (C170, DLD1, HCT15, COLO205), pancreatic (AsPC1, BxPC3, SUIT2) and lung (PC-9, PC-14, H1975, H441, A549) cancers and investigated possible predictive biomarkers. Among the derivatives, Compound3 showed the most potent growth-inhibitory effect and sensitivity between cell lines showed marked differences, with IC50 values ranging from 0.134 to 7.14 M. Pancreatic cancer cell line AsPC1 and non-small cell lung cancer (NSCLC) cell lines H441 and A549 which harbor KRAS mutation showed relatively high IC50 values compared to other cell lines without KRAS mutation. Compound3 induced G2/M arrest in all cell lines as early as 8 hours after the treatment by flowcytometry, while the increase of the apoptotic sub-G1 fraction was not observed in these AsPC1, H441 and A549 cells harboring KRAS mutation. These results suggested that differential sensitivity to Compound3 and attenuated induction of apoptosis by Compound3 were attributed to KRAS mutation. Induction of monoastral spindles formation by Compound3 was observed as early as 8 hours after the treatment not only in sensitive cell lines but in refractory cell lines such as AsPC1 and H441 cells by immunocytochemistry, suggesting the induction of monoastral spindles formation does not work as a predictive biomarker for clinical development. There was no correlation observed between the growth-inhibitory effect and the basal Eg5 expression level of each cell line by western blot analysis. No significant difference was observed in the induction of a spindle checkpoint kinase BubR1 phosphorylation among the cells, a possible predictive biomarker in response to the Eg5 inhibitor treatment by western blot analysis. Taken together, a novel mitotic kinesin Eg5 inhibitor Compound3 should be considered for further exploration and development and KRAS mutation status was suggested to be a candidate for a predictive biomarker of poor response to Eg5 inhibitors. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):C108.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.c.7429504.v1", "doi": "10.1158/1078-0432.c.7429504.v1", "title": "Data from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.c.7429504.v1", "pdfUrl": null, "abstract": "&lt;div&gt;AbstractPurpose:&lt;p&gt;To inform prognosis, treatment response, disease biology, and &lt;i&gt;KRAS G12C&lt;/i&gt; mutation heterogeneity, we conducted exploratory circulating tumor DNA (ctDNA) profiling on 134 patients with solid tumors harboring a &lt;i&gt;KRAS G12C&lt;/i&gt; mutation treated with single-agent divarasib (GDC-6036) in a phase 1 study.&lt;/p&gt;Experimental Design:&lt;p&gt;Plasma samples were collected for serial ctDNA profiling at baseline (cycle 1 day 1 prior to treatment) and multiple on-treatment time points (cycle 1 day 15 and cycle 3 day 1).&lt;/p&gt;Results:&lt;p&gt;&lt;i&gt;KRAS G12C&lt;/i&gt; ctDNA was detectable from plasma samples in 72.9% (43/59) and 92.6% (50/54) of patients with non–small cell lung cancer and colorectal cancer, respectively, the majority of whom were eligible for study participation based on a local test detecting the &lt;i&gt;KRAS G12C&lt;/i&gt; mutation in tumor tissue. Baseline ctDNA tumor fraction was associated with tumor type, disease burden, and metastatic sites. A decline in ctDNA level was observed as early as cycle 1 day 15. Serial assessment showed a decline in ctDNA tumor fraction associated with response and progression-free survival. Except for a few cases of &lt;i&gt;KRAS G12C&lt;/i&gt; sub-clonality, on-treatment changes in &lt;i&gt;KRAS G12C&lt;/i&gt; variant allele frequency mirrored changes in the overall ctDNA tumor fraction.&lt;/p&gt;Conclusions:&lt;p&gt;Across tumor types, the &lt;i&gt;KRAS G12C&lt;/i&gt; mutation likely represents a truncal mutation in the majority of patients. Rapid and deep decline in ctDNA tumor fraction was observed in patients responding to divarasib treatment. Early on-treatment dynamics of ctDNA were associated with patient outcomes and tumor response to divarasib treatment.&lt;/p&gt;&lt;/div&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1200/jco.2012.30.15_suppl.e14102", "doi": "10.1200/jco.2012.30.15_suppl.e14102", "title": "KRAS mutation profile in Puerto Rican patients with colorectal cancer: Trends in expression of KRAS mutation in PR between April 2009 to January 2011.", "publicationYear": 2012, "publicationDate": "2012-05-20", "type": "journal-article", "publisher": "American Society of Clinical Oncology (ASCO)", "containerTitle": "Journal of Clinical Oncology", "volume": "30", "issue": "15_suppl", "page": "e14102-e14102", "issn": "0732-183X, 1527-7755", "isbn": null, "authors": "Yelitza Ruiz, Christine Miranda, Robert F. Hunter", "authorCount": 3, "firstAuthorAffiliation": "PRHOG, Bayamon, PR", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1200/jco.2012.30.15_suppl.e14102", "pdfUrl": null, "abstract": "e14102 Background: The prevalence of a mutated KRAS gene in colorectal cancer shows ethnic variation with a range between 30-48% among the Caucasian, Asian, and European populations. The purpose of this study was to define the profile of KRAS mutation in colorectal cancer patients in Puerto Rico. Methods: Between April 2009 and January 2011, we collected the expression of KRAS gene among colorectal cancer patients in Puerto Rico. The assay was performed by a central laboratory which began to offer the test in the island in April 2009 (GENOPTIX). Data for the presence and type of mutation, age, sex, cancer histology, site of tumor, and cancer stage were collected. The site of the mutation in codon 12 and 13 were identified by the real time polymerase chain reaction (PCR). The study was approved by IRB. A total of 501 cases were available for study. SPPS version 14 was used for statistical analysis. Results: A mutated KRAS was present in 39% (n=195) of the cohort, more commonly in the 51-69 age group (55.4%; p=0.004), in females (55.4%; p=0.095), in the proximal area of colon (43.8%; p=0.017), in the codon 12 (91.2%), and 8.8% in the codon 13. The majority of mutated genes were in codon 12 (91.2%) with 12 ASP (39.5%) and 12 VAL (25.4%) most often seen. Mucinous histology was associated with 46.7% mutated KRAS, poorly differentiated tumor with 40.0% of KRAS mutation. The mutant expression of KRAS in cases with rectum carcinoma was 39.5%, where the most common mutation was 12 VAL. Conclusions: The prevalence of KRAS mutation in Puerto Rican population is similar to other reported studies. A higher prevalence of 12 VAL mutation in rectal carcinoma and a trend towards a higher mutation rate in females are different in this cohort as compared with published studies. This study was supported by NIH grant numbers G12RR-03035 &amp; 8U54MD007587-03.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1538-7445.am2022-2667", "doi": "10.1158/1538-7445.am2022-2667", "title": "Abstract 2667: Trial in progress: Phase 1 study of BI 1823911, an irreversible KRASG12C inhibitor targeting KRAS in its GDP-loaded state, as monotherapy and in combination with the pan-KRAS SOS1 inhibitor BI 1701963 in solid tumors expressing KRASG12C mutation", "publicationYear": 2022, "publicationDate": "2022-06-15", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Research", "volume": "82", "issue": "12_Supplement", "page": "2667-2667", "issn": "1538-7445", "isbn": null, "authors": "Irene C. Waizenegger, Hengyu Lu, Claus Thamer, Fabio Savarese, Daniel Gerlach, Dorothea Rudolph, Christopher P. Vellano, Marcelo Marotti, John Heymach, Scott Kopetz, Timothy P. Heffernan, Joseph R. Marszalek, Mark P. Petronczki, Marco H. Hofmann, Norbert Kraut", "authorCount": 15, "firstAuthorAffiliation": "1Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria;", "isReferencedByCount": 19, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1538-7445.am2022-2667", "pdfUrl": "https://aacrjournals.org/cancerres/article/82/12_Supplement/2667/699883/Abstract-2667-Trial-in-progress-Phase-1-study-of", "abstract": "Abstract Inhibition of KRASG12C mediated signaling and the therapeutic impact in non-small cell lung cancer (NSCLC) whose tumors carry this mutation was demonstrated clinically by sotorasib and adagrasib leading to approval of sotorasib in KRASG12C mutant NSCLC. These encouraging data are currently changing the treatment paradigm for patients with KRASG12C-mutated tumors. However only a fraction of patients is initially responding to these compounds and patients who achieved an objective response ultimately progressed on-treatment. It became clear from these studies that KRASG12C inhibitors require a combination partner to either achieve a deeper response initially or to prevent development of resistance. Multiple rational combination approaches are currently investigated with the goal to prolong duration of response or to overcome KRASG12C inhibitor resistance. The KRASG12C inhibitor BI 1823911 is more potent compared to sotorasib or adagrasib and showed comparable in vivo efficacy at a dose of 60 mg/kg vs. 100 mg/kg of either sotorasib or adagrasib in preclinical studies. The pan-KRAS SOS1 inhibitor BI 1701963 is the first direct KRAS signaling modifier, which entered phase I clinical trials both as a monotherapy as well as in combination with KRASG12C inhibitors, MEK inhibitors and irinotecan. Pan-KRAS SOS1 inhibitors exhibit activity against a broad spectrum of KRAS alleles, including the major G12D/V/C and G13D oncoproteins, while sparing the interaction of KRAS with SOS2. In the presented combination concept BI 1701963 shifts the balance of KRASG12C to its GDP-loaded form, which is the state to which BI 1823911 covalently binds to. Here, we present pre-clinical data showing enhanced pathway modulation and synergistic anti-tumor effects following vertical pathway inhibition of BI 1823911 in combination with BI 1701963. Our preclinical results supported the start of a phase I trial (NCT04973163), investigating the safety, tolerability, recommended dose and preliminary efficacy of BI 1823911 alone and in combination with the pan-KRAS SOS1 inhibitor BI 1701963. The trial includes cohorts of patients with KRASG12C mutant solid tumors, such as NSCLC, CRC, cholangiocarcinoma, and pancreatic adenocarcinoma, both KRAS therapy naïve or KRAS therapy relapsed. The first patients in the trial were treated in the monotherapy arm, dose escalation started at a dose of 50 mg. The combination therapy part is expected to start in Q1 2022. Primary endpoints include dose-limiting toxicities, treatment-emergent or -related adverse events. Secondary endpoints include pharmacokinetic properties of combination regimens and preliminary efficacy. Citation Format: Irene C. Waizenegger, Hengyu Lu, Claus Thamer, Fabio Savarese, Daniel Gerlach, Dorothea Rudolph, Christopher P. Vellano, Marcelo Marotti, John Heymach, Scott Kopetz, Timothy P. Heffernan, Joseph R. Marszalek, Mark P. Petronczki, Marco H. Hofmann, Norbert Kraut. Trial in progress: Phase 1 study of BI 1823911, an irreversible KRASG12C inhibitor targeting KRAS in its GDP-loaded state, as monotherapy and in combination with the pan-KRAS SOS1 inhibitor BI 1701963 in solid tumors expressing KRASG12C mutation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2667.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926606.v1", "doi": "10.1158/1078-0432.26926606.v1", "title": "Supplementary Figure S3 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926606.v1", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Figure S3&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.21203/rs.3.rs-1675918/v1", "doi": "10.21203/rs.3.rs-1675918/v1", "title": "Differences in gene mutation profiles of colon cancer patients with or without a KRAS mutation", "publicationYear": 2022, "publicationDate": "2022-06-03", "type": "posted-content", "publisher": "Research Square Platform LLC", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Shujian Chang, Yudan Zhou, Ruirong Wu, Xiaosong Ge, Yong Pu", "authorCount": 5, "firstAuthorAffiliation": "Affiliated Hospital of Jiangnan University", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.21203/rs.3.rs-1675918/v1", "pdfUrl": null, "abstract": "Abstract RAS plays an important role in the carcinogenesis of colorectal epithelial cells, but RAS mutations are only present, at most, in approximately 50% of patients. In order to compare the gene mutation profiles of patients with or without a KRAS mutation, the clinicopathological data of 858 patients and NGS test results of 1697 patients with colorectal cancer were used in this analysis. In 858 patients, the mutation rate of KRAS was 50.8% (i.e., 436/858). Only 2 out of 349 (0.5%) KRAS mutant patients had a BRAF mutation, while 25 out of 422 (5.9%) KRAS wild-type patients had a BRAF mutation (p &lt; 0.0001). The median OS of patients with a mutant or wild-type KRAS were 83.47 months and not reached, respectively (HR: 0.8147; 95% CI: 0.6271–1.051; p = 0.1153). The NGS results showed that in RAS mutant patients, genes with a high mutation rate mainly included APC, TP53, PIK3CA, Smad4, and Fbxw7, and in RAS wild-type patients, genes with a high mutation rate mainly included TP53, APC, LRP1B, MYC, and BRAF. The mutation rates of BRAF and EGFR in the RAS wild-type group were 15% and 9%, respectively, while they were only 3% in the RAS mutant group. The mutation rate of PIK3CA in the RAS mutant group was 31%, while that in the RAS wild-type group was 14%. The mutation rate of APC was 72.2% (i.e., 687/952). The mutation rate of the gene, RNF43, in the APC wild-type group was 5.23 times higher than that in the APC mutant group, and the gene, NSD1, in the APC wild-type group was 0.07 times higher than that in the APC mutant group. The mutation rate of TP53 was 78.2% (i.e., 744/952). The mutation rate of MLH1 in the TP53 wild-type group was 8.42 times higher than that in the TP53 mutant group, which was significantly higher than that in the TP53 mutant group. Generally, the gene mutation profiles were significantly different between KRAS mutation and wild-type colorectal cancer patients. A single gene mutation may be sufficient to cause the dysfunction of a signal transduction pathway, and APC, TP53, or RAS are not necessary for the carcinogenesis of sporadic colorectal cancer.", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926615", "doi": "10.1158/1078-0432.26926615", "title": "GO42144 INVESTIGATORS AND STUDY GROUP1 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926615", "pdfUrl": null, "abstract": "&lt;p&gt;GO42144 INVESTIGATORS AND STUDY GROUP&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926597", "doi": "10.1158/1078-0432.26926597", "title": "Supplementary Table S1 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926597", "pdfUrl": null, "abstract": "&lt;p&gt;Representativeness of Study Participants&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926600", "doi": "10.1158/1078-0432.26926600", "title": "Supplementary Figure S5 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926600", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Figure S5&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926609", "doi": "10.1158/1078-0432.26926609", "title": "Supplementary Figure S2 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926609", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Figure S2&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926597.v1", "doi": "10.1158/1078-0432.26926597.v1", "title": "Supplementary Table S1 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926597.v1", "pdfUrl": null, "abstract": "&lt;p&gt;Representativeness of Study Participants&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/2159-8290.cd-nb2019-092", "doi": "10.1158/2159-8290.cd-nb2019-092", "title": "Researchers Reveal Another KRAS Inhibitor", "publicationYear": 2019, "publicationDate": "2019-09-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Discovery", "volume": "9", "issue": "9", "page": "1152-1152", "issn": "2159-8274, 2159-8290", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/2159-8290.cd-nb2019-092", "pdfUrl": "https://aacrjournals.org/cancerdiscovery/article-pdf/9/9/1152/1847633/1152.pdf", "abstract": "Abstract Researchers have developed a KRAS inhibitor, BI-2852, that inhibits ERK phosphorylation and reduces proliferation of KRAS-mutant cancer cells. A drug based on the molecule may be effective in patients who don't respond to the KRASG12C inhibitors currently in clinical trials.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926600.v1", "doi": "10.1158/1078-0432.26926600.v1", "title": "Supplementary Figure S5 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926600.v1", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Figure S5&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926609.v1", "doi": "10.1158/1078-0432.26926609.v1", "title": "Supplementary Figure S2 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926609.v1", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Figure S2&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1538-7445.am2014-lb-209", "doi": "10.1158/1538-7445.am2014-lb-209", "title": "Abstract LB-209: Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance", "publicationYear": 2014, "publicationDate": "2014-10-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Research", "volume": "74", "issue": "19_Supplement", "page": "LB-209-LB-209", "issn": "0008-5472, 1538-7445", "isbn": null, "authors": "Meng Wang, Ashley M. Kern, Marieke Hülskötter, Patricia Greninger, Anurag Singh, Yunfeng Pan, Dipanjan Chowdhury, Mechthild Krause, Michael Baumann, Cyril H. Benes, Jason A. Efstathiou, Jeff Settleman, Henning Willers", "authorCount": 13, "firstAuthorAffiliation": "1Department of Radiation Oncology, Mass. General Hospital, Boston, MA;", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1538-7445.am2014-lb-209", "pdfUrl": "https://aacrjournals.org/cancerres/article/74/19_Supplement/LB-209/598543/Abstract-LB-209-Chromatin-condensation-in-KRAS", "abstract": "Abstract Non-small cell lung cancer (NSCLC) with mutations in the KRAS oncogene is generally resistant to targeted agents directed against the epidermal growth factor receptor (EGFR). Although EGFR is active in KRAS-mutant cancers its role in supporting cell survival and its potential utility as a therapeutic target have remained unclear. EGFR-targeted drugs have been shown to enhance the cytotoxic effects of radiation treatments (RT). However, clinical results have been inconsistent suggesting the need for genomic biomarkers to better identify a subset of patients in whom the combination of EGFR inhibitors and RT can be further developed. By carrying out a screen of 40 human NSCLC-derived cell lines, we establish a surprising positive correlation between the presence of a KRAS mutation and radiosensitization by the EGFR tyrosine kinase inhibitor erlotinib and the monoclonal antibody cetuximab. EGFR signaling in KRAS-mutant NSCLC cells promotes chromatin condensation in-vitro and in-vivo, thereby restricting the number of DNA double-strand breaks (DSB) produced by a given dose of RT. Chromatin condensation in interphase cells is characterized by an unexpected mitosis-like co-localization of serine 10 phosphorylation and lysine 9 trimethylation on histone H3. Aurora B kinase promotes this process in a manner that is co-dependent upon EGFR and protein kinase C alpha (PKCα) in KRAS-mutant but not wild-type cells. In keeping with a recently reported role of PKCα in breast cancer stem cells, disrupting the EGFR-PKCα pathway is particularly effective under experimental conditions that enrich for stem cell-like cancer cells including spheres. Interestingly, PKCα as well as MEK/ERK signaling is required for suppression of DSB-inducible premature senescence by EGFR. Blockade of autophagy results in a mutant KRAS-dependent senescence-to-apoptosis switch in cancer cells or spheres treated with RT. In conclusion, we identify EGFR as a molecular target to overcome a novel chromatin-mediated mechanism of RT resistance in KRAS-mutant tumor cells, thereby challenging the current paradigm of resistance of KRAS-mutant cancers to EGFR inhibitors. Our findings may reposition EGFR-targeted agents for combination with DSB-inducing therapies in KRAS-mutant NSCLC, and yield novel therapeutic opportunities to target chromatin modifications in cancer stem cells. Supported by the Dana-Farber/Harvard Cancer Center SPORE in Lung Cancer, NCI P50 CA090578, NCI R01 CA142698, American Cancer Society 123420RSG-12-224-01-DMC and RSG-12-079-01, UK Wellcome Trust 086357, Deutsche Forschungsgemeinschaft DFG-PAK-190, Federal Share of program income earned by Massachusetts General Hospital on C06 CA059267, Proton Therapy Research and Treatment Center. Citation Format: Meng Wang, Ashley M. Kern, Marieke Hülskötter, Patricia Greninger, Anurag Singh, Yunfeng Pan, Dipanjan Chowdhury, Mechthild Krause, Michael Baumann, Cyril H. Benes, Jason A. Efstathiou, Jeff Settleman, Henning Willers. Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-209. doi:10.1158/1538-7445.AM2014-LB-209", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926615.v1", "doi": "10.1158/1078-0432.26926615.v1", "title": "GO42144 INVESTIGATORS AND STUDY GROUP1 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926615.v1", "pdfUrl": null, "abstract": "&lt;p&gt;GO42144 INVESTIGATORS AND STUDY GROUP&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926603", "doi": "10.1158/1078-0432.26926603", "title": "Supplementary Figure S4 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926603", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Figure S4&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926612", "doi": "10.1158/1078-0432.26926612", "title": "Supplementary Figure S1 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926612", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Figure S1&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926606", "doi": "10.1158/1078-0432.26926606", "title": "Supplementary Figure S3 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926606", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Figure S3&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/2159-8290.cd-nb2021-0335", "doi": "10.1158/2159-8290.cd-nb2021-0335", "title": "Mechanisms of KRAS Inhibitor Resistance Revealed", "publicationYear": 2021, "publicationDate": "2021-06-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Discovery", "volume": "11", "issue": "6", "page": "1311-1312", "issn": "2159-8274, 2159-8290", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/2159-8290.cd-nb2021-0335", "pdfUrl": "https://aacrjournals.org/cancerdiscovery/article-pdf/11/6/1311/3104989/1311.pdf", "abstract": "Abstract A recent study revealed diverse mechanisms of acquired resistance in patients with non–small cell lung cancer or colorectal cancer who stop responding to a KRASG12C inhibitor. These patients developed secondary KRAS mutations, MAPK pathway alterations, or genomic rearrangements—and in some cases multiple resistance mechanisms occurred simultaneously.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1538-7445.am2025-6390", "doi": "10.1158/1538-7445.am2025-6390", "title": "Abstract 6390: Identification of novel pan-KRAS mutation inhibitor shows significant efficacy in pancreatic cancer with no toxicity, offering hope beyond current therapies", "publicationYear": 2025, "publicationDate": "2025-04-21", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Research", "volume": "85", "issue": "8_Supplement_1", "page": "6390-6390", "issn": "0008-5472, 1538-7445", "isbn": null, "authors": "Pinar Atalay, Asli Ture, Nermin Kahraman, Izabela Fokt, Waldemar Priebe, Erdem Buyukbingol, Bulent Ozpolat", "authorCount": 7, "firstAuthorAffiliation": "1Houston Methodist Research Institute, Houston, TX;", "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1538-7445.am2025-6390", "pdfUrl": "https://aacrjournals.org/cancerres/article/85/8_Supplement_1/6390/761122/Abstract-6390-Identification-of-novel-pan-KRAS", "abstract": "Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most challenging cancers to treat, with current therapies providing a median survival of just six months. The intrinsic chemoresistance and genetic heterogeneity of PDAC tumors complicate the development of effective targeted therapies. Approximately 90% of PDAC cases harbor KRAS mutations, which drive tumor initiation and progression, making KRAS a critical therapeutic target. Although the FDA has approved two KRAS inhibitors (Sotorasib and Adagrasib) for lung cancer, these drugs specifically target the KRAS-G12C mutation, found in only 2% of PDAC cases. Most PDAC tumors carry other KRAS mutations, particularly KRAS-G12D, leaving patients with limited targeted treatment options. To address this, we synthesized 21 compounds and identified 3E as a novel pan-KRAS inhibitor targeting KRAS-G12D, KRAS-G12C, and KRAS-G12S. Kaplan-Meier analysis of the TCGA PDAC database (n=177, p=0.00036) showed that elevated KRAS expression correlates with shorter survival, highlighting KRAS's role in PDAC progression. In vitro, treatment with 3E inhibited KRAS signaling in PDAC cells (PANC1, Miapaca-2) and KPC transgenic cells, as indicated by p-ERK suppression. 3E significantly reduced cell proliferation, migration, and invasion. Clonogenic assays demonstrated that 3E was more effective than Adagrasib and Salirasib (a non-specific RAS inhibitor in Phase II trials) at inhibiting PDAC cell growth. Moreover, 3E showed synergy with gemcitabine, a first-line chemotherapeutic agent for PDAC, enhancing its antiproliferative effects. In vivo, systemic delivery of 3E encapsulated in single lipid nanoparticles (SLNP) delayed tumor growth in PDAC xenograft and KPC transgenic mouse models without toxicity, as shown by blood chemistry markers. Tumor analysis after 3E treatment revealed reduced intra-tumoral proliferation (Ki-67 by IHC) and increased apoptosis (TUNEL assay). These findings suggest that 3E is a promising therapeutic candidate for KRAS-driven PDAC and other cancers. Its superior efficacy over FDA-approved KRAS inhibitors and synergy with gemcitabine support its clinical potential as a novel treatment approach for this aggressive cancer. Citation Format: Pinar Atalay, Asli Ture, Nermin Kahraman, Izabela Fokt, Waldemar Priebe, Erdem Buyukbingol, Bulent Ozpolat. Identification of novel pan-KRAS mutation inhibitor shows significant efficacy in pancreatic cancer with no toxicity, offering hope beyond current therapies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 6390.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926612.v1", "doi": "10.1158/1078-0432.26926612.v1", "title": "Supplementary Figure S1 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926612.v1", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Figure S1&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.26926603.v1", "doi": "10.1158/1078-0432.26926603.v1", "title": "Supplementary Figure S4 from Circulating Tumor DNA Dynamics Reveal &lt;i&gt;KRAS G12C&lt;/i&gt; Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors", "publicationYear": 2024, "publicationDate": "2024-09-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yoonha Choi, Neekesh V. Dharia, Tomi Jun, Julie Chang, Stephanie Royer-Joo, Kenneth K. Yau, Zoe J. Assaf, Junko Aimi, Smruthy Sivakumar, Meagan Montesion, Adrian Sacher, Patricia LoRusso, Jayesh Desai, Jennifer L. Schutzman, Zhen Shi", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.26926603.v1", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Figure S4&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1538-7445.am2026-2441", "doi": "10.1158/1538-7445.am2026-2441", "title": "Abstract 2441: The myCAF and ECM landscape in KRAS-mutated cancer: Utilizing liquid biomarkers to track KRAS-induced fibrosis and KRAS inhibitor efficacy", "publicationYear": 2026, "publicationDate": "2026-04-03", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Research", "volume": "86", "issue": "7_Supplement", "page": "2441-2441", "issn": "0008-5472, 1538-7445", "isbn": null, "authors": "Martin Birkmose Rasmussen, Rasmus Sund Pedersen, Nicholas Willumsen, Morten Karsdal", "authorCount": 4, "firstAuthorAffiliation": "Nordic Bioscience, Copenhagen, Denmark.", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1538-7445.am2026-2441", "pdfUrl": "https://aacrjournals.org/cancerres/article/86/7_Supplement/2441/778838/Abstract-2441-The-myCAF-and-ECM-landscape-in-KRAS", "abstract": "Abstract Background: KRAS-driven cancer represents ∼25% of cancers, with high rates in pancreatic cancer (PDAC), colorectal cancer (CRC), and non-small cell lung cancer (NSCLC). Mutated KRAS and TGF-β signaling activate cancer-associated fibroblasts (CAFs), creating a fibrotic extracellular matrix (ECM). The fibrotic ECM promotes immunosuppression and tumor growth but is potentially reversible with KRAS inhibitors (KRASi). We have recently demonstrated that myofibroblast CAFs (myCAFs) in KRAS-mutated PDAC express high levels of collagens III, V, VIII, XI, and XII. In this study, we investigated the landscape of KRAS-induced myCAF activation and ECM change across KRAS-mutated cancers. We utilized these changes to identify biomarkers for KRASi efficacy. Methods: Patients with KRAS-mutated PDAC (n=141), CRC (n=223), or NSCLC (n=74) were evaluated for collagen expression and gene-set variation analysis (GSVA) was used for hallmark KRAS and TGF-β signaling. Correlations of KRAS and TGF-β signaling, and collagen expressions across cancers, were evaluated using Spearman correlation. Single-cell RNA-seq data from KRASi treated KPPC mice was analyzed using Seurat. CAFs were subclustered and subtypes identified from marker genes (myCAF, inflammatory CAF, and antigen-presenting CAF). CAF subtype and collagen expression were compared between KRASi and vehicle with Fisher’s exact test and Wilcoxon rank-sum test, respectively. Biomarkers for formation of collagens I (PRO-C1), III (PRO-C3), V (PRO-C5), VIII (PRO-C8), XI (PRO-C11), and XII (PRO-C12) were measured in serum from healthy controls and patients with PDAC, CRC, or NSCLC. Differences between cancer and control were evaluated by Wilcoxon rank-sum test. Results: KRAS signaling was significantly correlated with TGF-β signaling and expression of COL3A1, COL5A2, and COL8A1 across patients with KRAS-mutated PDAC, CRC, and NSCLC (R&amp;gt;0.4, p&amp;lt;0.05). Significantly increased expression of Col3a1, Col5a2, Col8a1, Col11a1, and Col12a1 was observed from fibroblasts in KRASi treated PDAC compared to vehicle (p&amp;lt;0.001). Significantly fewer myCAFs in KRASi treated PDAC (p&amp;lt;0.001) suggested reduced myCAF-derived ECM with KRAS inhibition. Serum biomarkers for formation of myCAF collagens (PRO-C3, PRO-C5, PRO-C8, PRO-C11, and PRO-C12) were significantly upregulated in patients with PDAC, CRC, and NSCLC compared to healthy controls (p&amp;lt;0.001). Type I collagen formation was unaffected (PRO-C1, p=0.37), suggesting KRAS-specific collagen formation. Conclusion: KRAS-mutated tumors have a myCAF-enriched microenvironment with a unique collagen expression profile that is altered by KRAS inhibition. Non-invasive myCAF-derived collagen biomarkers that are elevated in serum from patients with KRAS-driven cancers, can potentially quantify KRAS signaling and track KRASi efficacy to guide clinical decision-making. Citation Format: Martin Birkmose Rasmussen, Rasmus Sund Pedersen, Nicholas Willumsen, Morten Karsdal. The myCAF and ECM landscape in KRAS-mutated cancer: Utilizing liquid biomarkers to track KRAS-induced fibrosis and KRAS inhibitor efficacy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 2441.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.4103/crst.crst_145_21", "doi": "10.4103/crst.crst_145_21", "title": "Sotorasib – an inhibitor of KRAS p.G12c mutation in advanced non-small cell carcinoma", "publicationYear": 2021, "publicationDate": "2021-07", "type": "journal-article", "publisher": "Medknow", "containerTitle": "Cancer Research, Statistics, and Treatment", "volume": "4", "issue": "3", "page": "524-528", "issn": "2590-3233", "isbn": null, "authors": "Amit Kumar Agrawal, Ramya Pragya, Amit Choudhary, Anuj Gupta, Kuraparthy Sambasivaiah, Bal Krishna Mishra, Satvik Khaddar, Akhil Kapoor", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4103/crst.crst_145_21", "pdfUrl": null, "abstract": "The KRAS p.G12C mutation occurs in seen in 13% of non-small cell lung cancers (NSCLCs) and in approximately 1%–3% of colorectal and other cancers. Until the last decade, there were no approved therapies for targeting the KRAS mutation, but recently, drugs targeting the mutation have been discovered. KRAS is a small protein structurally without any deep pockets making it almost impossible to target. Furthermore, it binds in its active state with the GTP protein, with remarkably close affinity making blockage of the KRAS mutation challenging. Sotorasib is a nanomolecule that selectively and irreversibly targets the KRAS mutation. The phase 2 trial (CodeBreaK100) conducted in a total of 129 patients with advanced solid tumors harboring the KRAS p.G12C mutation showed anticancer activity in patients following multiple lines of treatment. We searched for the articles published online between 2018 and May 2021 with keywords, “KRAS mutation,” “lung cancer,” and “sotorasib.” In this review article, we have discussed the history, pharmacokinetics, dosing, important studies, toxicities, and other pertinent details of sotorasib.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/2159-8290.cd-nb2020-098", "doi": "10.1158/2159-8290.cd-nb2020-098", "title": "Another KRAS Inhibitor Holds Its Own", "publicationYear": 2020, "publicationDate": "2020-12-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Discovery", "volume": "10", "issue": "12", "page": "OF2-OF2", "issn": "2159-8274, 2159-8290", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/2159-8290.cd-nb2020-098", "pdfUrl": "https://aacrjournals.org/cancerdiscovery/article/10/12/OF2/2593/Another-KRAS-Inhibitor-Holds-Its-OwnAnother-KRAS", "abstract": "Abstract According to the KRYSTAL-1 study, the KRASG12c inhibitor adagrasib, also known as MRTX849, is largely well tolerated and shows considerable efficacy in patients with non–small cell lung cancer harboring this mutation. The drug is also active, albeit more modestly, in colorectal cancer and several other solid tumor types.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/2159-8290.cd-nb2021-0362", "doi": "10.1158/2159-8290.cd-nb2021-0362", "title": "FDA Approves First KRAS Inhibitor: Sotorasib", "publicationYear": 2021, "publicationDate": "2021-08-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Discovery", "volume": "11", "issue": "8", "page": "OF4-OF4", "issn": "2159-8274, 2159-8290", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 39, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/2159-8290.cd-nb2021-0362", "pdfUrl": "https://aacrjournals.org/cancerdiscovery/article/11/8/OF4/666268/FDA-Approves-First-KRAS-Inhibitor-SotorasibFDA", "abstract": "Abstract The FDA has approved the first KRAS-targeted therapy, sotorasib, for patients with previously treated non-small cell lung cancer with KRASG12C mutations. In a phase II trial, the drug yielded a median progression-free survival of 6.8 months in patients whose disease had advanced despite treatment with standard therapies, namely platinum-based chemotherapy and PD-1–PD-L1 inhibitors.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.31466/kfbd.981849", "doi": "10.31466/kfbd.981849", "title": "Comparison of KRAS Mutation Status with Clinical Parameters in Colon Adenocarcinoma", "publicationYear": 2021, "publicationDate": "2021-12-15", "type": "journal-article", "publisher": "Karadeniz Fen Bilimleri Dergisi", "containerTitle": "Karadeniz Fen Bilimleri Dergisi", "volume": "11", "issue": "2", "page": "648-662", "issn": "2564-7377", "isbn": null, "authors": "Barış BOYLU, Mustafa TÜRKMEN", "authorCount": 2, "firstAuthorAffiliation": "Giresun Üniversitesi", "isReferencedByCount": 0, "referenceCount": 38, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.31466/kfbd.981849", "pdfUrl": null, "abstract": "KRAS mutations are mutually exclusive with other activating mutations on EGFR pathway. Detection of KRAS mutations associated with tumorigenesis, predicates the lack of other mutations on the same pathway and shows that the application of targeted therapy approaches which target other proteins in EGFR-MAPK pathway ineffective. In this study, frequency of KRAS mutations in colorectal cancer and relationship between KRAS mutation status and other clinical features were assessed. KRAS mutations were detected in 47,7% of the cases included in our study. We determined that 76% of the mutations were located in codon 12, 9% of the mutations were located in codon 13, 9% of the mutations were located in codon 61 and 6% of the mutations located in codon 117 or codon 146. Determination of mutation rates and association of mutations with clinical features for different populations are important for planning of the treatment strategies nationwide. In our study, we have demonstrated that KRAS mutation status and clinical features associated with KRAS mutation is in accordance with the literature. We have determined that there is statistically significant correlation between grade and KRAS mutation status.", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/2159-8290.cd-nb2020-089", "doi": "10.1158/2159-8290.cd-nb2020-089", "title": "KRAS Inhibitor Continues to Impress in NSCLC", "publicationYear": 2020, "publicationDate": "2020-11-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Discovery", "volume": "10", "issue": "11", "page": "1617-1617", "issn": "2159-8274, 2159-8290", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/2159-8290.cd-nb2020-089", "pdfUrl": "https://aacrjournals.org/cancerdiscovery/article-pdf/10/11/1617/1816282/1617.pdf", "abstract": "Abstract Evidence continues to grow that KRAS, once considered an “undruggable” target, can be targeted successfully in non–small cell lung cancer. In a phase I trial, the KRASG12C inhibitor sotorasib elicited responses in about a third of patients with the disease and was generally well tolerated.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.26434/chemrxiv.15002376/v1", "doi": "10.26434/chemrxiv.15002376/v1", "title": "D33E mutation reshapes active and inactive conformations of KRAS", "publicationYear": 2026, "publicationDate": "2026-04-24", "type": "posted-content", "publisher": "American Chemical Society (ACS)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Nicholas A. Carton, Maxim Mulligan, Brajesh Narayan, Nicolae-Viorel Buchete", "authorCount": 4, "firstAuthorAffiliation": "School of Physics", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26434/chemrxiv.15002376/v1", "pdfUrl": null, "abstract": "GTP-bound KRAS cycles between inactive and active conformations through coordinated rearrangements of Switch I and Switch II, yet the structural and kinetic consequences of many clinically observed mutations remain unresolved. The rare D33E substitution lies within the electrostatic network of Switch I and, despite being chemically conservative, exhibits tumorigenesis. Here, we use extensive atomistic simulations and Markov state models (MSMs) of GTP-bound KRAS to characterize how D33E reshapes its conformational landscape and kinetics, including its propensity to sample conformations associated with CRAF binding. Free energy projections along established distance-based reaction coordinates d 1 and d 2 (distances from C a atoms of residues 60 and 35 to γ phosphate) reveal that D33E stabilises switch GTP engaged conformations. Structural mapping of experimentally derived RAS structures onto the simulated landscape identifies two clusters: an inactive cluster and an active, effector binding competent cluster. MSM analysis reveals that D33E substantially enriches the fully switch engaged S1 ensemble, primarily through a sevenfold reduction in exit rates rather than accelerated entry. The negatively charged E37 side chain adopts a new conformation in low d 2 states, not observed in the wildtype, correlating with movements in E62 towards the GTP nucleotide, promoting the S 1 state. S 1 overlaps with experimentally observed effector-bound and GAP-bound complexes in the structural mapping. Within this binding-competent ensemble, D33E rigidifies both switch regions locally and reduces the frequency at which Q61 adopts the catalytic approach geometry required for GAP-stimulated hydrolysis. Together, these observations are consistent with the biochemical profile of D33E, in which enhanced effector binding coincides with substantially reduced GAP stimulated catalysis. This suggests ensemble level population redistribution as a potential contributing mechanism to the oncogenic signaling of D33E. These results shed new light on understanding how mutations modulate KRAS activity.", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.70389/pjs.100001", "doi": "10.70389/pjs.100001", "title": "Targeting the Undruggable KRAS Mutation in Lung Cancer: A Review", "publicationYear": 2024, "publicationDate": "2024-10-27", "type": "journal-article", "publisher": "Premier Science", "containerTitle": "Premier Journal of Science", "volume": null, "issue": null, "page": null, "issn": "3049-9011", "isbn": null, "authors": "Clark Jones", "authorCount": 1, "firstAuthorAffiliation": "Pharmaceutical Scientist and Molecular Biologist", "isReferencedByCount": 0, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/3.0/deed.en_US", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.70389/pjs.100001", "pdfUrl": null, "abstract": "Targeting the KRAS mutation in lung cancer has proven to be a challenging yet essential task due to its intricate signaling mechanisms and high prevalence in non-small cell lung cancer (NSCLC). Despite historical setbacks, recent advancements have led to the approval of targeted therapies such as sotorasib and adagrasib, offering new hope for patients with KRAS-mutated lung cancer. Ongoing research and development efforts have introduced several promising candidates in the pipeline, showcasing promising compounds like a pan-KRAS inhibitor, which could potentially transform the treatment landscape for KRAS-mutant cancers. Artificial intelligence (AI) in accelerating drug discovery for KRAS-targeted therapies, leveraging machine learning algorithms to analyze vast amounts of data and predict the efficacy of potential drug candidates. AI- driven drug discovery is revolutionizing the field by enabling researchers to explore novel treatment strategies and develop innovative therapies for KRAS-mutant cancers. AI may be utilized to develop personalized treatment regimens, predict outcomes, and revolutionize the landscape of precision medicine for lung cancer patients with KRAS mutations. Through a combination of cutting-edge research, combination therapies, and AI-driven innovation, recent advancements illustrate profound hope in the field of targeting the historically undruggable KRAS mutation in lung cancer.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.c.8630813", "doi": "10.1158/1078-0432.c.8630813", "title": "Data from The SOS1 Inhibitor BI 1701963 as Monotherapy or in Combination with Trametinib in Patients with &lt;i&gt;KRAS&lt;/i&gt; Mutation-Positive Solid Tumors", "publicationYear": 2026, "publicationDate": "2026-08-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Pasi A. Jänne, Melissa L. Johnson, Jin Li, Shubham Pant, Ulrich Dünzinger, Luis Ilia, Kerstin Möldner, Jae Eui Soh, Noboru Yamamoto", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.c.8630813", "pdfUrl": null, "abstract": "&lt;div&gt;Abstract Purpose:&lt;p&gt;BI 1701963 is a small-molecule son of sevenless 1 (SOS1) inhibitor that selectively binds to SOS1, blocking the protein–protein interaction of SOS1 with guanosine diphosphate-bound rat sarcoma virus (RAS) proteins [Kirsten RAS (KRAS), Harvey RAS, and neuroblastoma RAS], thereby inhibiting the growth of RAS-dependent cancer cells.&lt;/p&gt; Patients and Methods:&lt;p&gt;Three phase I dose-escalation studies evaluated BI 1701963 as monotherapy (starting dose of 50 mg) or in combination with trametinib (starting dose of 100 mg/1 mg) in patients with &lt;i&gt;KRAS&lt;/i&gt; mutation-positive solid tumors (NCT04111458, USA and Europe; NCT04835714, Japan; and NCT04627142, China). Primary endpoints were maximum tolerated dose (MTD) based on dose-limiting toxicities (DLT; part A NCT04111458) and the number of patients with DLT in the MTD evaluation period (part A NCT04111458 and NCT04835714) or the on-treatment period (Part B NCT04835714).&lt;/p&gt; Results:&lt;p&gt;Ninety-four patients were treated: 75 with monotherapy (50–800 mg) and 19 in combination (100 mg/1 mg; 100 mg/1.5 mg; and 200 mg/1 mg). Six monotherapy patients (8%) and six combination patients (31.6%) experienced DLT in the MTD evaluation period. All patients experienced adverse events; of note, three monotherapy patients had interstitial lung disease during the first treatment cycle, leading to death, which was considered drug-related by the investigator. In the monotherapy group, one patient (1.8%) experienced a partial response, and 12 patients (21.8%) had stable disease. In the combination group, four patients (33.3%) had stable disease, carrying different KRAS alleles.&lt;/p&gt; Conclusions:&lt;p&gt;BI 1701963 treatment demonstrated limited efficacy as monotherapy. MTD was determined to be 800-mg monotherapy (NCT04111458) and 100 mg/1 mg in combination with trametinib (NCT04111458).&lt;/p&gt;&lt;/div&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1101/2022.12.16.520846", "doi": "10.1101/2022.12.16.520846", "title": "A non-conserved histidine residue on KRAS drives paralog selectivity of the KRAS G12D inhibitor MRTX1133", "publicationYear": 2022, "publicationDate": "2022-12-19", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Miles A. Keats, John J. W. Han, Yeon-Hwa Lee, Chih-Shia Lee, Ji Luo", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 15, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/2022.12.16.520846", "pdfUrl": null, "abstract": "Abstract The discovery of small molecule inhibitors against mutant KRAS protein was a recent breakthrough in targeted therapy. Understanding the mechanism of selectivity by KRAS inhibitors and the mechanism of resistance to them can guide the future development of KRAS inhibitors. MRTX1133 was the first non-covalent inhibitor against the KRAS G12D mutant that demonstrated specificity and potency in pre-clinical tumor models. We used isogenic cell lines expressing a single RAS allele to evaluate the selectivity of this compound. We found that in addition to KRAS G12D, MRTX1133 shows significant activity against several other KRAS mutants as well as wildtype KRAS protein. In contrast, MRTX1133 exhibits no activity against both G12D and wildtype forms of HRAS and NRAS proteins. Functional analysis revealed that the selectivity of MRTX1133 towards KRAS is associated with its binding to histidine 95 on KRAS, a residue that is not conserved in HRAS and NRAS. Reciprocal mutation of amino acid 95 among the three RAS paralogs resulted in reciprocal change in their sensitivity towards MRTX1133. Thus, histidine 95 is an essential selectivity handle for MRTX1133 towards KRAS. This knowledge could aid the development of future KRAS-selective inhibitors.", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/2159-8290.cd-rw2021-167", "doi": "10.1158/2159-8290.cd-rw2021-167", "title": "Resistant KRAS(G12C) Inhibitor Subclones Exhibit Heterogeneous Alterations", "publicationYear": 2022, "publicationDate": "2022-01-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Discovery", "volume": "12", "issue": "1", "page": "13-13", "issn": "2159-8274, 2159-8290", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/2159-8290.cd-rw2021-167", "pdfUrl": "https://aacrjournals.org/cancerdiscovery/article-pdf/12/1/13/3019863/13a.pdf", "abstract": "Abstract KRAS(G12C) inhibitor (G12Ci) resistance exhibits a heterogeneous pattern with no one dominant alteration.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.33143537", "doi": "10.1158/1078-0432.33143537", "title": "Supplementary Table S4 from The SOS1 Inhibitor BI 1701963 as Monotherapy or in Combination with Trametinib in Patients with &lt;i&gt;KRAS&lt;/i&gt; Mutation-Positive Solid Tumors", "publicationYear": 2026, "publicationDate": "2026-08-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Pasi A. Jänne, Melissa L. Johnson, Jin Li, Shubham Pant, Ulrich Dünzinger, Luis Ilia, Kerstin Möldner, Jae Eui Soh, Noboru Yamamoto", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.33143537", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Table S4: Pharmacokinetic parameters of BI 1701963 monotherapy (Studies NCT04111458, NCT04835714 and NCT04627142)&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.3390/cancers17071237", "doi": "10.3390/cancers17071237", "title": "Trends in Overall Survival in Lung Adenocarcinoma with EGFR Mutation, KRAS Mutation, or No Mutation", "publicationYear": 2025, "publicationDate": "2025-04-05", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Cancers", "volume": "17", "issue": "7", "page": "1237", "issn": "2072-6694", "isbn": null, "authors": "Martin Faehling, Sabine Fallscheer, Birgit Schwenk, Harald Seifarth, Jörn Sträter, Claudia Lengerke, Petros Christopoulos", "authorCount": 7, "firstAuthorAffiliation": "Clinic of Cardiology and Pneumology, Esslingen Hospital, 73730 Esslingen, Germany", "isReferencedByCount": 2, "referenceCount": 56, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "German Cancer Consortium", "funderIds": "10.13039/501100012353", "url": "https://doi.org/10.3390/cancers17071237", "pdfUrl": null, "abstract": "Background: Treatment of lung adenocarcinoma has changed and now includes checkpoint inhibitors (CPIs) or, in the case of an EGFR mutation, third-generation EGFR TKI osimertinib. Few data compare the long-term overall survival (OS) of current and historic subgroups. Methods: This real-world analysis (KOMPASS study) included stage IV lung-adenocarcinoma patients with either EGFR, KRAS, or no mutation. Patients were assigned to the “current” EGFR, KRAS, or no-mutation cohort if they had mutation testing using NGS (n = 199; median date of diagnosis 2021). If they had an EGFR PCR test only, they were assigned to the “historic” EGFR or no-mutation cohort (n = 127; median date of diagnosis 2014). Results: Both the current and the historic EGFR cohorts had significantly longer OS than the respective no-mutation cohorts (HR 0.58 and 0.60, respectively). The current no-mutation and EGFR cohorts had a strong trend to longer OS than the respective historic cohorts. In the no-mutation cohorts, the improvement was due to an increase in long-term survivors (HR 0.71), whereas in the EGFR mutation cohorts, the median OS was improved without long-term survivors (HR 0.70). The KRAS cohort showed OS like the no-mutation cohort, with a plateau of long-term survivors around 20%. Conclusions: A comparison of our data with that of the phase III trials KEYNOTE-189 and FLAURA suggests that the improved outcomes are due to the use of CPIs or osimertinib. The clinical trial results are well translated into real-world clinical practice with comparable OS. KRAS patients benefit from CPI treatment like no-mutation patients.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.33143549", "doi": "10.1158/1078-0432.33143549", "title": "Supplementary Figure S2 from The SOS1 Inhibitor BI 1701963 as Monotherapy or in Combination with Trametinib in Patients with &lt;i&gt;KRAS&lt;/i&gt; Mutation-Positive Solid Tumors", "publicationYear": 2026, "publicationDate": "2026-08-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Pasi A. Jänne, Melissa L. Johnson, Jin Li, Shubham Pant, Ulrich Dünzinger, Luis Ilia, Kerstin Möldner, Jae Eui Soh, Noboru Yamamoto", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.33143549", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Figure S2. Ki67 Proliferative Index from tumor biopsies taken at screening and at Day 16 of Cycle 1 in patients treated in NCT04111458&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1538-7445.am2019-2197", "doi": "10.1158/1538-7445.am2019-2197", "title": "Abstract 2197: The AXL kinase inhibitor, TP-0903, demonstrates efficacy in preclinical models of colorectal cancer independent of KRAS mutation status", "publicationYear": 2019, "publicationDate": "2019-07-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Research", "volume": "79", "issue": "13_Supplement", "page": "2197-2197", "issn": "0008-5472, 1538-7445", "isbn": null, "authors": "Ryan Mangelson, Peter Peterson, Jason M. Foulks, Yuta Matsumura, Lars Mouritsen, Clifford J. Whatcott, David J. Bearss, Steven L. Warner", "authorCount": 8, "firstAuthorAffiliation": "Tolero Pharmaceuticals, Inc., Lehi, UT.", "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1538-7445.am2019-2197", "pdfUrl": "https://aacrjournals.org/cancerres/article/79/13_Supplement/2197/634210/Abstract-2197-The-AXL-kinase-inhibitor-TP-0903", "abstract": "Abstract Colorectal cancer (CRC) is the third leading cause of cancer-related mortality in the US (2017). Most patients present with stage II or III disease at diagnosis, with the 5-year survival rate between 53-89%. Survival in patients with stage IV CRC, however, is a discouraging 11%. Metastasis in CRC is linked to a mesenchymal phenotype, which is associated with chemoresistance. AXL, a receptor tyrosine kinase, promotes the mesenchymal phenotype in cancer cells and its expression is associated with drug resistance and poor outcomes. TP-0903, a clinical-stage, investigational small molecule inhibitor of AXL has been shown to reverse the mesenchymal phenotype and restore drug sensitivity in cells that no longer respond to standard agents in preclinical models. TP-0903 is hypothesized to be an active agent in CRC through reversal of the mesenchymal phenotype. In cell viability assays of CRC lines, TP-0903 treatment resulted in IC50 values ranging from 4.5 – 123 nM. Notably, cell growth inhibition by TP-0903 was independent of KRAS mutation status; the KRAS mutant HCT-116 line was the most sensitive CRC cell line tested. Mesenchymal markers, including Snail, were suppressed by 7.6-fold (mRNA) and 4.9-fold (protein) in the HCT-116 line at 500 nM. TP-0903 activity was also assessed in vivo using two KRAS mutant CRC models: HCT-116 and a patient-derived xenograft (PDX) model. In the HCT-116 xenograft model, single agent TP-0903 treatment achieved 69% tumor growth inhibition (%TGI) with an oral dosing schedule at 40 mg/kg. In a KRAS-mutant PDX model, TP-0903 achieved 44% TGI when mice were dosed at 40 mg/kg. Pharmacodynamic analyses were performed on tissues from the HCT-116 and PDX models. The ligand for AXL, GAS6, was significantly upregulated in tissues after TP-0903 treatment in both CRC in vivo models while soluble AXL and GAS6 were significantly downregulated in plasma in the PDX model. Furthermore, Axin2, a Wnt/β-catenin regulated gene, was downregulated by TP-0903 in tumor tissue from the PDX model, suggesting inhibition of the Wnt/βcatenin pathway. These data support a potential role for AXL in the promotion of the mesenchymal phenotype in CRC, and showed that AXL inhibition by TP-0903 suppressed the mesenchymal phenotype and was effective against CRC cells regardless of KRAS mutation status. These observations support further clinical investigation of TP-0903 as a potential therapeutic agent in metastatic CRC. A Phase I trial with this investigational agent is ongoing, including patients with KRAS mutant CRC (clincaltrials.gov, NCT02729298). Citation Format: Ryan Mangelson, Peter Peterson, Jason M. Foulks, Yuta Matsumura, Lars Mouritsen, Clifford J. Whatcott, David J. Bearss, Steven L. Warner. The AXL kinase inhibitor, TP-0903, demonstrates efficacy in preclinical models of colorectal cancer independent of KRAS mutation status [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2197.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.20944/preprints202105.0471.v1", "doi": "10.20944/preprints202105.0471.v1", "title": "The KRAS G12C mutation in NSCLC: from target to resistance", "publicationYear": 2021, "publicationDate": "2021-05-20", "type": "posted-content", "publisher": "MDPI AG", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Alfredo Addeo, Giuseppe Luigi Banna, Alex Friedlaender", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 15, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.20944/preprints202105.0471.v1", "pdfUrl": null, "abstract": "Lung cancer represents the most common form of cancer accounting for 1.8 million deaths globally in 2020.The 5-year relative survival rate for lung cancer is lower than many other leading cancer types. Over the last decade the treatment for advanced and metastatic non small cell lung cancer have dramatically improved due to the development of immune checkpoint inhibitors and the identification of targetable driver mutations. Recently, potentially effective inhibitors of a hitherto untargetable oncogenic driver mutation in NSCLC, Kirsten Rat Sarcoma (KRAS) have been developed. KRAS mutations are found in 20-25% of NSCLC and represent the most frequent mutation. The mutation is almost exclusively detected in adenocarcinoma and is found among smokers 90% of the time. Along with the development of new drugs that have been showing promising activity, resistance mechanisms have begun to be clarified. The aim of this review is to unwrap the biology of KRAS in NSCLC with a specific focus on primary and secondary resistance mechanisms and their possible clinical implications.", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.33143552", "doi": "10.1158/1078-0432.33143552", "title": "Supplementary Figure S1 from The SOS1 Inhibitor BI 1701963 as Monotherapy or in Combination with Trametinib in Patients with &lt;i&gt;KRAS&lt;/i&gt; Mutation-Positive Solid Tumors", "publicationYear": 2026, "publicationDate": "2026-08-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Pasi A. Jänne, Melissa L. Johnson, Jin Li, Shubham Pant, Ulrich Dünzinger, Luis Ilia, Kerstin Möldner, Jae Eui Soh, Noboru Yamamoto", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.33143552", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Figure S1: Geometric mean drug plasma concentration-time profiles of BI 1701963 QD after single and multiple administrations.&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1078-0432.33143543", "doi": "10.1158/1078-0432.33143543", "title": "Supplementary Table S2 from The SOS1 Inhibitor BI 1701963 as Monotherapy or in Combination with Trametinib in Patients with &lt;i&gt;KRAS&lt;/i&gt; Mutation-Positive Solid Tumors", "publicationYear": 2026, "publicationDate": "2026-08-03", "type": "posted-content", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Pasi A. Jänne, Melissa L. Johnson, Jin Li, Shubham Pant, Ulrich Dünzinger, Luis Ilia, Kerstin Möldner, Jae Eui Soh, Noboru Yamamoto", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1078-0432.33143543", "pdfUrl": null, "abstract": "&lt;p&gt;Supplementary Table S2: Representativeness of study participants with KRAS mutation-positive solid tumors&lt;/p&gt;", "subject": null, "language": null, "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.1158/1557-3125.ras18-ia19", "doi": "10.1158/1557-3125.ras18-ia19", "title": "Abstract IA19: Insight towards therapeutic susceptibility of KRAS-mutant cancers from MRTX1257, a novel KRAS G12C mutant-selective small-molecule inhibitor", "publicationYear": 2020, "publicationDate": "2020-05-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Molecular Cancer Research", "volume": "18", "issue": "5_Supplement", "page": "IA19-IA19", "issn": "1541-7786, 1557-3125", "isbn": null, "authors": "James G. Christensen", "authorCount": 1, "firstAuthorAffiliation": "Mirati Therapeutics, San Diego, CA.", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1557-3125.ras18-ia19", "pdfUrl": "https://aacrjournals.org/mcr/article/18/5_Supplement/IA19/233844/Abstract-IA19-Insight-towards-therapeutic", "abstract": "Abstract The ability to effectively target mutated KRAS has remained elusive despite decades of research. By solving a highly informative set of ligand-complexed co-crystal structures coupled with iterative structure-based drug design, substituted tetrahydropyridopyrimidines were identified as selective, covalent inhibitors of mutant KRAS G12C. MRTX1257 emerged from this chemical series as a research tool compound that demonstrates the ability to irreversibly bind to the KRAS G12C variant, trap it in the inactive GDP-bound state, and inhibit ERK1/2 phosphorylation with an IC50 value of 1 nM. Therefore, a number of studies with MRTX1257 (and other prototype inhibitors) were designed to provide insight towards the breadth of therapeutic response and the underlying molecular mechanisms of sensitivity and resistance to KRAS inhibition. The evaluation of an extended panel of KRAS G12C mutant cell lines in cell viability and survival assays indicated that the vast majority of cell lines responded at concentrations under 50 nM, but that the concentration-response range varied by two orders of magnitude (0.2-62 nM). To extend these analyses to in vivo studies, MRTX1257 demonstrated clear evidence of dose-dependent irreversible modification of KRAS G12C and inhibition of KRAS-dependent signal transduction in multiple KRAS G12C mutant tumor models. MRTX1257 was then evaluated at a fixed dose that yielded near-complete KRAS target inhibition across an additional large panel of KRAS G12C-mutant subcutaneous cell-derived and patient-derived xenografts and demonstrated broad-spectrum antitumor activity including frank tumor regressions (often exceeding 50% tumor reduction) in approximately 80% of all models evaluated (n = 23). In contrast, MRTX1257 was inactive in non-KRAS G12C-mutant cell lines in vitro and tumor models in vivo, indicating that the antitumor activity of this molecule was mediated through binding to and inhibition of the KRAS G12C variant. The antitumor response across tumor models varied in KRAS G12C positive models from complete tumor regression with no evidence of recovery after treatment cessation, to partial response, to tumor stasis. In addition, a small subset of models demonstrated rapid initial tumor regression followed by tumor stasis, suggesting that there may be mechanisms of adaptive tolerance to MRTX1257 treatment. Based on this response pattern, temporal effects on signal transduction and molecules implicated in feedback signaling were evaluated. In a temporal pattern consistent with drug tolerance kinetics, MAP kinase pathway reactivation was observed based on rebound of pERK and pS6 signaling despite continuous treatment. Also consistent with signaling rebound dynamics and drug tolerance, downregulation of dual specificity phosphatases (DUSPs), Sprouty family (SPRY), and ETVs along with decoupling of cell cycle from KRAS regulatory constraints was observed. Based on these observations, a number of combination strategies designed to co-target signaling feedback pathways were evaluated in tumor models and provided direct insight into the importance of rebound pathways and response and the practical value of rational combination approaches. Together, these data indicate the therapeutic susceptibility and broad dependence of KRAS G12C mutation-positive tumors on KRAS for tumor cell growth and survival and provide insight toward the molecular basis of response to single-agent and combinatorial therapies. Citation Format: James G. Christensen. Insight towards therapeutic susceptibility of KRAS-mutant cancers from MRTX1257, a novel KRAS G12C mutant-selective small-molecule inhibitor [abstract]. In: Proceedings of the AACR Special Conference on Targeting RAS-Driven Cancers; 2018 Dec 9-12; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Res 2020;18(5_Suppl):Abstract nr IA19.", "subject": null, "language": "en", "_run_id": "qo8UvdggP3AX1mbfD", "_dataset_id": "gjZobmodLEvlFmgXK"}
{"paperId": "10.2139/ssrn.5205537", "doi": "10.2139/ssrn.5205537", "title": "Emergent Sentience in Large Language Models Emergent Sentience in Large Language Models: Transformer Architecture and the Neurological Foundations of Consciousness", "publicationYear": 2025, "publicationDate": "2025", "type": "posted-content", "publisher": "Elsevier BV", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Michael Rivera", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 20, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.5205537", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.5220/0012960200004508", "doi": "10.5220/0012960200004508", "title": "Comparison and Analysis of Large Language Models Based on Transformer", "publicationYear": 2024, "publicationDate": "2024", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the 1st International Conference on Engineering Management, Information Technology and Intelligence", "volume": null, "issue": null, "page": "597-602", "issn": null, "isbn": null, "authors": "Yingying Chang", "authorCount": 1, "firstAuthorAffiliation": "School of Information and Management Sciences, Henan Agricultural University, Zhengzhou, China, --- Select a Country ---", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0012960200004508", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1007/979-8-8688-2733-4_2", "doi": "10.1007/979-8-8688-2733-4_2", "title": "Inside the Transformer: Core Architectures", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Apress", "containerTitle": "Mastering Large Language Models", "volume": null, "issue": null, "page": "33-76", "issn": null, "isbn": "9798868827327, 9798868827334", "authors": "Ajay Rawat, Vardan Pathak", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/979-8-8688-2733-4_2", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.2139/ssrn.6199178", "doi": "10.2139/ssrn.6199178", "title": "Security and Risk Implications of Transformer-Based Large Language Models", "publicationYear": 2026, "publicationDate": "2026", "type": "posted-content", "publisher": "Elsevier BV", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Sergey Saburov", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.6199178", "pdfUrl": null, "abstract": "The growing adoption of Large Language Models (LLMs) across a wide range of applications has introduced new challenges in application security, complementing traditional deterministic software approaches rather than replacing them entirely. While this transition enables advanced capabilities in automated reasoning and content generation, it also exposes architectural characteristics that remain insufficiently addressed by many existing cybersecurity frameworks. A core security challenge arises from the use of natural language as a unified representational medium for both instructions and data within modern generative systems. Unlike classical computing architectures, where a strict separation exists between executable instructions and passive data, LLMs process system instructions and user inputs as undifferentiated sequences of natural-language tokens. This architectural property introduces a form of semantic ambiguity in which untrusted data may be interpreted as instructions under certain contextual conditions, leading to unintended model behaviour. This paper examines the security and risk implications of this ambiguity through architectural, operational, and legal lenses. Particular attention is given to agent-based systems and Retrieval-Augmented Generation (RAG) pipelines, where indirect prompt injection, tool abuse, and excessive model agency expand the attack surface beyond purely digital environments into physical systems and complex organizational supply chains. The analysis highlights the limitations of existing security assumptions and motivates the need for systemic resilience strategies tailored to LLM-driven systems.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.4018/979-8-3373-2038-0.ch005", "doi": "10.4018/979-8-3373-2038-0.ch005", "title": "Transformative Role of Transformer Models in Healthcare", "publicationYear": 2025, "publicationDate": "2025-08-29", "type": "book-chapter", "publisher": "IGI Global Scientific Publishing", "containerTitle": "Transformative Role of Transformer Models in Healthcare", "volume": null, "issue": null, "page": "123-160", "issn": null, "isbn": "9798337320380, 9798337320403", "authors": "Deepa Lakshmi S.", "authorCount": 1, "firstAuthorAffiliation": "PG & Research Department of Computer Science, Dwaraka Doss Goverdhan Doss Vaishnav College, India", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4018/979-8-3373-2038-0.ch005", "pdfUrl": null, "abstract": "Artificial Intelligence (AI) is a field of computer science that enables machines to learn, interpret, and make decisions like humans. In healthcare, AI is driving transformation by introducing systems that simulate human behavior and reasoning. The sector produces vast amounts of structured and unstructured data. AI tools can process this information, integrate data from various sources, and identify patterns to support predictive decision-making. Machine Learning (ML), a subset of AI, and Deep Learning (DL), a subset of ML, play a key role in this advancement. Large Language Models (LLMs), part of DL, help machines analyze and generate human-like language. These models use Transformer architectures, known for capturing long-range dependencies in text. This chapter focuses on transformer-based models, especially BERT (Bidirectional Encoder Representations from Transformers), an encoder-only model. It also includes a practical application of BERT for detecting suicidal ideation in Reddit posts, highlighting its value in clinical sentiment analysis.", "subject": null, "language": "ng", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.20944/preprints202602.0680.v1", "doi": "10.20944/preprints202602.0680.v1", "title": "Security and Risk Implications of Transformer-Based Large Language Models", "publicationYear": 2026, "publicationDate": "2026-02-09", "type": "posted-content", "publisher": "MDPI AG", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Sergey Saburov", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.20944/preprints202602.0680.v1", "pdfUrl": null, "abstract": "The growing adoption of Large Language Models (LLMs) across a wide range of applications has introduced new challenges in application security, complementing traditional deterministic software approaches rather than replacing them entirely. While this transition enables advanced capabilities in automated reasoning and content generation, it also exposes architectural characteristics that remain insufficiently addressed by many existing cybersecurity frameworks.A core security challenge arises from the use of natural language as a unified representational medium for both instructions and data within modern generative systems. Unlike classical computing architectures, where a strict separation exists between executable instructions and passive data, LLMs process system instructions and user inputs as undifferentiated sequences of natural-language tokens. This architectural property introduces a form of semantic ambiguity in which untrusted data may be interpreted as instructions under certain contextual conditions, leading to unintended model behaviour.This paper examines the security and risk implications of this ambiguity through architectural, operational, and legal lenses. Particular attention is given to agent-based systems and Retrieval-Augmented Generation (RAG) pipelines, where indirect prompt injection, tool abuse, and excessive model agency expand the attack surface beyond purely digital environments into physical systems and complex organizational supply chains. The analysis highlights the limitations of existing security assumptions and motivates the need for systemic resilience strategies tailored to LLM-driven systems.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.21203/rs.3.rs-4640131/v1", "doi": "10.21203/rs.3.rs-4640131/v1", "title": "AI Content Self-Detection for Transformer-based large Language Models", "publicationYear": 2024, "publicationDate": "2024-07-31", "type": "posted-content", "publisher": "Springer Science and Business Media LLC", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Antonio Caiado, Michael Hahsler", "authorCount": 2, "firstAuthorAffiliation": "Southern Methodist University", "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.21203/rs.3.rs-4640131/v1", "pdfUrl": null, "abstract": "Abstract The usage of generative artificial intelligence (AI)tools based on large language models, including ChatGPT, Bard, and Claude, for text generation, has many exciting applications with the potential for phenomenal productivity gains. One issue is authorship attribution when using AI tools. This is especially important in an academic setting where the inappropriate use regenerative AI tools may hinder student learning or stifle research by, creating a large amount of automatically generated derivative work. Existing plagiarism detection systems can trace the source of submitted text but are not yet equipped with methods to accurately detect AI-generated text. This paper introduces the dea of direct origin detection and evaluates whether generative AI systems can recognize their output and distinguish it from human-written texts. We argue why current transformer-based models may be able to self-detect their own generated text and perform a small empirical study using zero-shot learning to investigate if that is the case. Results reveal varying capabilities of AI systems to identify their generated text. Google’s Bard model exhibits the largest capability of self-detection with an accuracy of 94%, followed by OpenAI’s ChatGPT with 83%.On the other hand, Anthropic’s Claude model seems to be not able to self-detect.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.36227/techrxiv.171925719.97800486/v1", "doi": "10.36227/techrxiv.171925719.97800486/v1", "title": "Mathematical Foundations of Hallucination in Transformer-Based Large Language Models for Improvisation", "publicationYear": 2024, "publicationDate": "2024-06-24", "type": "posted-content", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Ahmet Gundogmusler, Fatma Bayindiroglu, Mustafa Karakucukoglu", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-sa/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.36227/techrxiv.171925719.97800486/v1", "pdfUrl": null, "abstract": "Transformer architectures have revolutionized natural language processing through their ability to handle longrange dependencies and generate contextually coherent text. Despite their impressive capabilities, these models frequently produce outputs that are not directly grounded in the input data, a phenomenon known as hallucination. The paper posits that hallucination is not merely a flaw but a mathematical necessity for enabling improvisation within transformer-based large language models. Through rigorous theoretical analysis, the relationship between hallucination and improvisation is explored, demonstrating that the probabilistic nature of language generation inherently leads to outputs extending beyond the training data. The proofs and lemmas presented substantiate the claim that hallucinations are essential for the model's ability to generate novel and creative responses. The research further delves into the implications of this necessity, suggesting a reevaluation of performance metrics and training strategies to balance accuracy with creativity. The findings highlight the intricate dynamics between hallucination and improvisation, providing foundational insights into the design and evaluation of transformer-based models.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.36227/techrxiv.171865245.51607046/v1", "doi": "10.36227/techrxiv.171865245.51607046/v1", "title": "Mathematical Foundations of Hallucination in Transformer-Based Large Language Models for Improvisation", "publicationYear": 2024, "publicationDate": "2024-06-17", "type": "posted-content", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Ahmet Gundogmusler, Fatma Bayindiroglu, Mustafa Karakucukoglu", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-sa/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.36227/techrxiv.171865245.51607046/v1", "pdfUrl": null, "abstract": "Transformer architectures have revolutionized natural language processing through their ability to handle longrange dependencies and generate contextually coherent text. Despite their impressive capabilities, these models frequently produce outputs that are not directly grounded in the input data, a phenomenon known as hallucination. The paper posits that hallucination is not merely a flaw but a mathematical necessity for enabling improvisation within transformer-based large language models. Through rigorous theoretical analysis, the relationship between hallucination and improvisation is explored, demonstrating that the probabilistic nature of language generation inherently leads to outputs extending beyond the training data. The proofs and lemmas presented substantiate the claim that hallucinations are essential for the model’s ability to generate novel and creative responses. The research further delves into the implications of this necessity, suggesting a reevaluation of performance metrics and training strategies to balance accuracy with creativity. The findings highlight the intricate dynamics between hallucination and improvisation, providing foundational insights into the design and evaluation of transformer-based models.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.36227/techrxiv.173610898.84404151/v1", "doi": "10.36227/techrxiv.173610898.84404151/v1", "title": "A Systematic Review on Optimization Approaches for Transformer and Large Language Models", "publicationYear": 2025, "publicationDate": "2025-01-05", "type": "posted-content", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Atefeh Hemmati, Fatemeh Bazikar, Amir Masoud Rahmani, Hossein Moosaei", "authorCount": 4, "firstAuthorAffiliation": "Department of Computer Engineering, Science and Research Branch, Islamic Azad University", "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.36227/techrxiv.173610898.84404151/v1", "pdfUrl": null, "abstract": "Large language models (LLMs) are deep learning (DL) algorithms that can perform a range of natural language processing (NLP) tasks. LLMs use transformer models trained using large datasets and have revolutionized NLP tasks. However, their large-scale implementation poses significant computational resources, efficiency, and scalability challenges. This systematic literature review (SLR) examines optimization techniques applied to transformer and LLM models from 2020 to 2024. We analyzed 32 papers to provide an overview of optimization methods and highlight their impact on model performance and computational efficiency. Additionally, we examine the evolution of these techniques, highlight implementation challenges, and propose future research directions for optimization. In addition, we discuss the evaluation factors, environments, and datasets commonly used to evaluate optimization techniques and explore the applications of LLMs in real-world scenarios. Finally, we emphasize the critical role of optimization in improving the performance, reducing costs, and enhancing the scalability of transformer models and LLMs and provide insights into emerging trends and opportunities for future research in this area.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.20944/preprints202410.1348.v1", "doi": "10.20944/preprints202410.1348.v1", "title": "Investigating the Predominance of Large Language Models in Low-Resource Bangla Language Over Transformer Models for Hate Speech Detection: A Comparative Analysis", "publicationYear": 2024, "publicationDate": "2024-10-17", "type": "posted-content", "publisher": "MDPI AG", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Fatema Tuj Johora Faria, Laith H. Baniata, Sangwoo Kang", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.20944/preprints202410.1348.v1", "pdfUrl": null, "abstract": "The rise of abusive language on social media is a significant threat to mental health and 1 social cohesion. For Bengali speakers, the need for effective detection is critical. However, current 2 methods fall short in addressing the massive volume of content. Improved techniques are urgently 3 needed to combat online hate speech in Bengali. Traditional machine learning techniques, while 4 useful, often require large, linguistically diverse datasets to train models effectively. This paper 5 addresses the urgent need for improved hate speech detection methods in Bengali, aiming to fill the 6 existing research gap. Contextual understanding is crucial in differentiating between harmful speech 7 and benign expressions. Large language models (LLMs) have shown state-of-the-art performance in 8 various natural language tasks due to their extensive training on vast amounts of data. We explore the 9 application of LLMs, specifically GPT-3.5 Turbo and Gemini 1.5 Pro, for Bengali hate speech detection 10 using Zero-Shot and Few-Shot Learning approaches. Unlike conventional methods, Zero-Shot 11 Learning identifies hate speech without task-specific training data, making it highly adaptable to new 12 datasets and languages. Few-Shot Learning, on the other hand, requires minimal labeled examples, 13 allowing for efficient model training with limited resources. Our experimental results show that 14 LLMs outperform traditional approaches. In this study, we evaluated GPT-3.5 Turbo and Gemini 1.5 15 Pro on multiple datasets. To further enhance our study, we considered the distribution of comments 16 in different datasets and the challenge of class imbalance, which can affect model performance. The 17 BD-SHS dataset consists of 35,197 comments in the training set, 7,542 in the validation set, and 7,542 18 in the test set. The Bengali Hate Speech Dataset v1.0 &amp;amp; v2.0 includes comments distributed across 19 various hate categories: personal hate (629), political hate (1,771), religious hate (502), geopolitical hate 20 (1,179), and gender abusive hate (316). The Bengali Hate Dataset comprises 7,500 non-hate and 7,500 21 hate comments. GPT-3.5 Turbo achieved impressive results with 97.33%, 98.42%, and 98.53% accuracy. 22 In contrast, Gemini 1.5 Pro showed lower performance across all datasets. Specifically, GPT-3.5 Turbo 23 excelled with significantly higher accuracy compared to Gemini 1.5 Pro. These outcomes highlight a 24 6.28% increase in accuracy compared to traditional methods, which achieved 92.25%. Our research 25 contributes to the growing body of literature on LLM applications in natural language processing, 26 particularly in the context of low-resource languages.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.36227/techrxiv.173337226.68077827/v1", "doi": "10.36227/techrxiv.173337226.68077827/v1", "title": "Contextual Pathway Reconfiguration for Efficient Multimodal Understanding in Transformer-based Large Language Models", "publicationYear": 2024, "publicationDate": "2024-12-05", "type": "posted-content", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Michael Kobrun, Jacob Fitzwilliam, Isabella Montmorency, Alexander Krajewski, Edward Sandringham", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-sa/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.36227/techrxiv.173337226.68077827/v1", "pdfUrl": null, "abstract": "Contextual pathway reconfiguration introduces a dynamic approach to enhancing the performance and adaptability of transformer-based architectures in multimodal settings. By incorporating hierarchical gating mechanisms and auxiliary embedding layers, the proposed framework efficiently prioritizes and synthesizes information across diverse input modalities, addressing long-standing challenges in feature alignment and integration. Extensive experiments demonstrated consistent improvements in performance metrics across a variety of tasks, including image captioning and video question answering, showcasing the model's ability to generalize effectively while maintaining computational efficiency. The reinforcement learning-driven pathway evaluation mechanism emerged as a critical component, enabling real-time adjustments to computational pathways based on contextual input demands. Comparisons with traditional transformer methodologies highlighted the modular design's superiority in both scalability and robustness, particularly in handling noise-prone and unbalanced datasets. An in-depth analysis of latency and throughput further demonstrated the model's potential for deployment in high-demand, real-time applications. Error analysis revealed specific cases of improvement in cross-modal reasoning while identifying areas where input noise posed residual challenges. Ablation studies validated the significance of individual architectural components, confirming their contribution to overall model performance. The novel approach to dynamically reconfiguring attention mechanisms has broad implications for advancing multimodal applications, offering a versatile solution to integrate textual, visual, and auditory data. Additionally, energy efficiency assessments demonstrated the model's practicality for both training and inference scenarios, enhancing its viability for large-scale use. The findings present a compelling case for redefining multimodal transformer architectures to balance precision, efficiency, and adaptability, paving the way for more robust and versatile implementations.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.7551/mitpress/15517.003.0003", "doi": "10.7551/mitpress/15517.003.0003", "title": "Large Language Models", "publicationYear": 2025, "publicationDate": "2025-10-28", "type": "book-chapter", "publisher": "The MIT Press", "containerTitle": "Large Language Models", "volume": null, "issue": null, "page": "1-18", "issn": null, "isbn": "9780262383523", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.7551/mitpress/15517.003.0003", "pdfUrl": "https://direct.mit.edu/books/book/chapter-pdf/2560640/c000400_9780262383523.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1109/fllm67465.2025.11391180", "doi": "10.1109/fllm67465.2025.11391180", "title": "Automating Sarcasm Identification from App Reviews Using Transformer-based Language Models", "publicationYear": 2025, "publicationDate": "2025-11-25", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 3rd International Conference on Foundation and Large Language Models (FLLM)", "volume": null, "issue": null, "page": "1116-1118", "issn": null, "isbn": null, "authors": "Khubaib Amjad Alam, Bisma Shahid, Muhammad Haroon, Qaisar Shafi, Momina Kamal Cheema", "authorCount": 5, "firstAuthorAffiliation": "Al Ain University,College of Engineering,United Arab Emirates", "isReferencedByCount": 0, "referenceCount": 8, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/fllm67465.2025.11391180", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1007/979-8-8688-2297-1_9", "doi": "10.1007/979-8-8688-2297-1_9", "title": "Transformer Block and Full Transformer Model—It’s Time to Put the Puzzle Together", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Apress", "containerTitle": "Building Large Language Models from Scratch", "volume": null, "issue": null, "page": "325-366", "issn": null, "isbn": "9798868822964, 9798868822971", "authors": "Dilyan Grigorov", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/979-8-8688-2297-1_9", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.31219/osf.io/k495f", "doi": "10.31219/osf.io/k495f", "title": "Semantic Layer Reconstruction in Large Language Models Using Multi-Level Transformer Feedback Mechanisms", "publicationYear": 2024, "publicationDate": "2024-12-05", "type": "posted-content", "publisher": "Center for Open Science", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Charles Welling, Beatrix Longborough, Barnaby Winterbourne, Isabella Eisenhardt", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.31219/osf.io/k495f", "pdfUrl": null, "abstract": "Semantic Layer Reconstruction introduces a transformative mechanism for refining the interactions between transformer layers, leveraging recursive feedback to enhance semantic coherence across linguistic tasks. The framework incorporates a multi-level feedback mechanism that recalibrates token embeddings through bidirectional propagation of semantic cues, addressing challenges such as semantic drift and alignment inefficiencies. By dynamically integrating higher-layer abstractions into earlier computational processes, the approach fosters a more coherent synthesis of token-level and contextual representations. Experimental evaluations reveal significant improvements in perplexity, BLEU scores, and semantic similarity indices, highlighting the framework's ability to address complex linguistic phenomena. Layer-wise analyses underscore the critical contributions of middle layers in achieving optimal semantic alignment, while attention-weight distributions demonstrate a more balanced contextual focus. The recursive feedback mechanism also proved instrumental in capturing long-range dependencies, showcasing its utility in tasks requiring deep contextual understanding. Comparative configurations further validated the adaptability of the mechanism, with dynamic recursive intervals outperforming static approaches across all metrics. Noise-resilience experiments highlighted the model's robustness, while visualizations of semantic drift reduction provided compelling evidence of improved coherence. The integration of the mechanism into existing transformer architectures maintained computational efficiency through optimizations such as sparse attention and modularity. The study bridges theoretical innovations with empirical validation, offering a scalable and adaptable solution for advancing the semantic capabilities of transformer-based architectures. The findings provide a foundation for redefining the paradigms of contextual representation and layer-wise interaction in contemporary language modeling.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1109/iisec59749.2023.10391040", "doi": "10.1109/iisec59749.2023.10391040", "title": "Enhancing Text Summarization: Evaluating Transformer-Based Models and the Role of Large Language Models like ChatGPT", "publicationYear": 2023, "publicationDate": "2023-12-21", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2023 4th International Informatics and Software Engineering Conference (IISEC)", "volume": null, "issue": null, "page": "1-4", "issn": null, "isbn": null, "authors": "Pınar Savcı, Bihter Das", "authorCount": 2, "firstAuthorAffiliation": "Ar&#x00E7;elik A.&#x015E;.,Istanbul,Turkey", "isReferencedByCount": 4, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/iisec59749.2023.10391040", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.31219/osf.io/7qbsa_v1", "doi": "10.31219/osf.io/7qbsa_v1", "title": "Contextual Residual Inversion in Transformer-Based Large Language Models: A Reversibility Paradigm for Studying Representational Fidelity", "publicationYear": 2025, "publicationDate": "2025-03-24", "type": "posted-content", "publisher": "Center for Open Science", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Daniel Arthev, Richard Abercrombie, Clive Fenwick", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.31219/osf.io/7qbsa_v1", "pdfUrl": null, "abstract": "Contextual Residual Inversion introduces a theoretical and computational approach for estimating partial reversibility of internal residual streams in transformer-based LLMs through non-invasive linear inversion operators applied to frozen inference passes. The method defines invertibility over structured prompt families by quantifying layer-wise reconstruction fidelity using projection-constrained residual approximations. Inversion accuracy is examined under varying lexical entropy, token classes, and layer depth, revealing substantial directional drift and energy compression patterns in deeper layers. Semantic stability of inverted representations is further analyzed through KL divergence and centroid shift in token distributions, demonstrating mild correlation between residual fidelity and generative coherence. Residual operators trained on specific prompt clusters show degradation when generalized across structurally divergent prompts, suggesting sensitivity to latent representation regimes not apparent from surface form alone. Metrics including cosine similarity, semantic drift score, and re-alignment ratio provide modest insight into the underlying activation structure governing token-wise representation. Experimental data is drawn from controlled synthetic prompts using a sparse Mixture-of-Experts LLM architecture, enabling reproducible assessments of inversion fragility and directional bias. The findings offer an interpretable, layer-sensitive perspective on the reversibility and geometric constraints of contextual encoding in high-capacity generative systems.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.22541/au.173145004.42488699/v1", "doi": "10.22541/au.173145004.42488699/v1", "title": "Dynamic Probabilistic Contextual Realignment in Transformer-Based Large Language Models for Semantic Consistency", "publicationYear": 2024, "publicationDate": "2024-11-12", "type": "posted-content", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yukito Odorico, Kousuke Hayashi, Isamu Kiryu, Kenta Yamagata, Daiki Masuda, Shohei Shinohara", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-sa/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22541/au.173145004.42488699/v1", "pdfUrl": null, "abstract": "The rapid evolution of artificial intelligence has led to the development of sophisticated language models capable of generating human-like text. However, maintaining semantic consistency throughout extended text generation remains a significant challenge. Introducing Dynamic Probabilistic Contextual Realignment (DPCR), a novel methodology that dynamically adjusts contextual embeddings through probabilistic realignment, addresses this issue by mitigating semantic drift. The integration of DPCR into transformer-based large language models (LLMs) has demonstrated substantial improvements in semantic coherence and contextual relevance. Quantitative analyses reveal enhanced performance metrics, while qualitative assessments highlight more coherent and contextually appropriate text generation. The findings demonstrate the potential of DPCR to advance LLM development and applications across various domains, emphasizing the importance of dynamic context management in achieving semantic consistency.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1109/fllm63129.2024.10852494", "doi": "10.1109/fllm63129.2024.10852494", "title": "Enhancing Named Entity Recognition in Arabic: Leveraging Transformer-Based Models and Open Data Sources", "publicationYear": 2024, "publicationDate": "2024-11-26", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2024 2nd International Conference on Foundation and Large Language Models (FLLM)", "volume": null, "issue": null, "page": "357-361", "issn": null, "isbn": null, "authors": "Faiza Belbachir, Assia Soukane", "authorCount": 2, "firstAuthorAffiliation": "Laboratoire de Recherche LYRIDS,Ecole d&#x2019;ing&#x00E9;nieurs Campus de Paris (ECE),Paris,France", "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/fllm63129.2024.10852494", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.18653/v1/2024.clinicalnlp-1.16", "doi": "10.18653/v1/2024.clinicalnlp-1.16", "title": "Conversational Topic Recommendation in Counseling and Psychotherapy with Decision Transformer and Large Language Models", "publicationYear": 2024, "publicationDate": "2024", "type": "proceedings-article", "publisher": "Association for Computational Linguistics", "containerTitle": "Proceedings of the 6th Clinical Natural Language Processing Workshop", "volume": null, "issue": null, "page": "196-201", "issn": null, "isbn": null, "authors": "Aylin Gunal, Baihan Lin, Djallel Bouneffouf", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.18653/v1/2024.clinicalnlp-1.16", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1007/979-8-8688-2785-3_3", "doi": "10.1007/979-8-8688-2785-3_3", "title": "Advanced Transformer Architectures", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Apress", "containerTitle": "Transformers and Large Language Models", "volume": null, "issue": null, "page": "123-183", "issn": null, "isbn": "9798868827846, 9798868827853", "authors": "Ahmed Fawzy Gad", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/979-8-8688-2785-3_3", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1007/979-8-8688-0515-8_1", "doi": "10.1007/979-8-8688-0515-8_1", "title": "Introduction to Large Language Models with OpenAI", "publicationYear": 2024, "publicationDate": "2024", "type": "book-chapter", "publisher": "Apress", "containerTitle": "Large Language Models Projects", "volume": null, "issue": null, "page": "3-29", "issn": null, "isbn": "9798868805141, 9798868805158", "authors": "Pere Martra", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/979-8-8688-0515-8_1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1007/979-8-8688-2216-2_7", "doi": "10.1007/979-8-8688-2216-2_7", "title": "Unpacking the Transformer Architecture", "publicationYear": 2025, "publicationDate": "2025", "type": "book-chapter", "publisher": "Apress", "containerTitle": "The Practical Guide to Large Language Models", "volume": null, "issue": null, "page": "295-348", "issn": null, "isbn": "9798868822155, 9798868822162", "authors": "Ivan Gridin", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/979-8-8688-2216-2_7", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1109/i3ctcon68242.2026.11507131", "doi": "10.1109/i3ctcon68242.2026.11507131", "title": "Context-Aware Transformer Optimization for Improved Generalization in Large Language Models", "publicationYear": 2026, "publicationDate": "2026-03-14", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2026 IEEE International Conference for Convergence in Computing Technology (I3CTCON)", "volume": null, "issue": null, "page": "1-6", "issn": null, "isbn": null, "authors": "Santosh Datta Bompally", "authorCount": 1, "firstAuthorAffiliation": "Webster University,Independent Security Researcher,MO,63119", "isReferencedByCount": 0, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/i3ctcon68242.2026.11507131", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.3905/jfds.2025.1.198", "doi": "10.3905/jfds.2025.1.198", "title": "Quantitative Models with Qualitative Scenarios: Simulation with Transformer and Large Language Models", "publicationYear": 2025, "publicationDate": "2025-07-31", "type": "journal-article", "publisher": "With Intelligence LLC", "containerTitle": "The Journal of Financial Data Science", "volume": "7", "issue": "3", "page": "116-131", "issn": "2640-3943", "isbn": null, "authors": "Irene Aldridge, Daham Kim", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3905/jfds.2025.1.198", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.3390/electronics15142988", "doi": "10.3390/electronics15142988", "title": "Hierarchical Classification of Arabic Legal Cases Using Transformer Architectures and Large Language Models", "publicationYear": 2026, "publicationDate": "2026-07-08", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Electronics", "volume": "15", "issue": "14", "page": "2988", "issn": "2079-9292", "isbn": null, "authors": "Nourah Alangari, Nouf Alshenaifi, Huda Almuzaini", "authorCount": 3, "firstAuthorAffiliation": "Computer Science Department, College of Computer and Information Sciences, King Saud University, Riyadh 11543, Saudi Arabia", "isReferencedByCount": 0, "referenceCount": 26, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/electronics15142988", "pdfUrl": null, "abstract": "Automated classification of Arabic legal texts presents unique challenges stemming from the formal register of judicial language, domain-specific Sharī‘a terminology, and the severe class imbalance inherent in hierarchical legal taxonomies. This paper addresses these challenges through a systematic investigation of hierarchical multi-class classification applied to a dataset of 1146 Arabic judicial cases sourced from the Saudi Ministry of Justice open data portal. Cases are annotated at two hierarchical levels: a binary main-class distinction between criminal and civil cases (L1), and a fine-grained sub-category classification across 63 legal topics (L2), exhibiting a class imbalance ratio of 43:1. We evaluate three methodological families under four classification architectures. For encoder-only models, we fine-tune AraBERT, CAMeL-BERT, MARBERTv2, and XLM-RoBERTa under Flat (Bottom-Up), Hierarchical Multi-Task, Two-Stage, and Hierarchy-Aware configurations. For encoder–decoder models, we adapt AraT5v2 under the same four architectures. Finally, we conduct a prompt-based evaluation of GPT-4o under zero-shot and targeted few-shot settings. The experimental results demonstrate that the Hierarchy-Aware architecture consistently achieves the strongest fine-grained classification performance across both model families. AraBERTv2 with Hierarchy-Aware training achieves the best overall L2 accuracy of 83.04% and a Macro-F1 of 76.07%, while the Single Multi-Task configuration achieves the highest L1 accuracy of 99.57%. GPT-4o under 5-shot prompting achieves 99.13% L1 accuracy and a competitive L2 Macro-F1 of 74.30% without task-specific fine-tuning, though supervised models maintain stronger overall fine-grained performance. These findings highlight the importance of explicit hierarchical supervision and domain-adapted pre-training for Arabic legal text classification, and establish strong baselines for future research in this underexplored domain.", "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1007/979-8-8688-2733-4_1", "doi": "10.1007/979-8-8688-2733-4_1", "title": "Introduction to Large Language Models", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Apress", "containerTitle": "Mastering Large Language Models", "volume": null, "issue": null, "page": "3-31", "issn": null, "isbn": "9798868827327, 9798868827334", "authors": "Ajay Rawat, Vardan Pathak", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/979-8-8688-2733-4_1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.5220/0012717200003756", "doi": "10.5220/0012717200003756", "title": "Artificial Intelligence-Powered Large Language Transformer Models for Opioid Abuse and Social Determinants of Health Detection for the Underserved Population", "publicationYear": 2024, "publicationDate": "2024", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the 13th International Conference on Data Science, Technology and Applications", "volume": null, "issue": null, "page": "15-26", "issn": null, "isbn": null, "authors": "Don Roosan, Yanting Wu, Jay Chok, Christopher Sanine, Tiffany Khou, Yawen Li, Hasiba Khan", "authorCount": 7, "firstAuthorAffiliation": "Western University of Health Sciences, College of Pharmacy, 309 E 2nd Street, Pomona, CA, U.S.A.", "isReferencedByCount": 9, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0012717200003756", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.18653/v1/2025.xllm-1.10", "doi": "10.18653/v1/2025.xllm-1.10", "title": "Seamlessly Integrating Tree-Based Positional Embeddings into Transformer Models for Source Code Representation", "publicationYear": 2025, "publicationDate": "2025", "type": "proceedings-article", "publisher": "Association for Computational Linguistics", "containerTitle": "Proceedings of the 1st Joint Workshop on Large Language Models and Structure Modeling (XLLM 2025)", "volume": null, "issue": null, "page": "91-98", "issn": null, "isbn": null, "authors": "Patryk Bartkowiak, Filip Graliński", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.18653/v1/2025.xllm-1.10", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1007/978-3-031-76646-6_26", "doi": "10.1007/978-3-031-76646-6_26", "title": "In the Engine Room: Transformer Models", "publicationYear": 2025, "publicationDate": "2025", "type": "book-chapter", "publisher": "Springer Nature Switzerland", "containerTitle": "Synthesis Lectures on Human-Centered Informatics", "volume": null, "issue": null, "page": "193-202", "issn": "1946-7680, 1946-7699", "isbn": "9783031766459, 9783031766466", "authors": "Clayton Lewis", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-3-031-76646-6_26", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1007/979-8-8688-0540-0_2", "doi": "10.1007/979-8-8688-0540-0_2", "title": "What Are Large Language Models?", "publicationYear": 2024, "publicationDate": "2024", "type": "book-chapter", "publisher": "Apress", "containerTitle": "Introduction to Python and Large Language Models", "volume": null, "issue": null, "page": "59-100", "issn": null, "isbn": "9798868805394, 9798868805400", "authors": "Dilyan Grigorov", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/979-8-8688-0540-0_2", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.31219/osf.io/bj7xc_v1", "doi": "10.31219/osf.io/bj7xc_v1", "title": "Large Language Models with Novel Token Processing Architecture: A Study of the Dynamic Sequential Transformer", "publicationYear": 2024, "publicationDate": "2024-10-22", "type": "posted-content", "publisher": "Center for Open Science", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Kusi Men, Na Pin, Shumei Lu, Qian Zhang, Huanhuan Wang", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.31219/osf.io/bj7xc_v1", "pdfUrl": null, "abstract": "The increasing complexity and scale of language models have introduced significant challenges related to computational efficiency, inference speed, and the generation of factually accurate responses. Addressing these issues, a novel architectural enhancement known as the Dynamic Sequential Transformer (DST) has been proposed, offering a groundbreaking approach to token processing through dynamic token sequencing and adaptive attention recalibration. By introducing a more flexible and context-aware method for handling tokenized inputs, DST improves both accuracy and speed while reducing the occurrence of hallucinations, which are a common problem in language generation tasks. The experimental results have demonstrated that the DST architecture significantly reduces memory usage, accelerates inference times, and improves model convergence rates, making it an efficient solution for large-scale deployments without sacrificing output quality. Additionally, DST's modular design ensures scalability and robustness across diverse language processing tasks, positioning it as a promising advancement for practical real-world applications. Through extensive evaluation, the study confirms that DST not only optimizes resource utilization but also enhances the linguistic coherence and factual consistency of generated text, establishing a new benchmark for architectural efficiency in modern language models.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1201/9781003474173-5", "doi": "10.1201/9781003474173-5", "title": "Deep Learning Transformer Architecture", "publicationYear": 2024, "publicationDate": "2024-05-28", "type": "book-chapter", "publisher": "Chapman and Hall/CRC", "containerTitle": "Artificial Intelligence and Large Language Models", "volume": null, "issue": null, "page": "153-190", "issn": null, "isbn": "9781003474173", "authors": "Kutub Thakur, Helen G. Barker, Al-Sakib Khan Pathan", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1201/9781003474173-5", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.2139/ssrn.5175593", "doi": "10.2139/ssrn.5175593", "title": "Construction of Collaborative Intelligent Manufacturing Agents For Special Transformer Coil Workshop Based on Large Language Models And Digital Twins", "publicationYear": 2025, "publicationDate": "2025", "type": "posted-content", "publisher": "Elsevier BV", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Xuedong Zhang, Wenlei Sun, Ke Chen, Renben Jiang", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.5175593", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.5220/0014649700004058", "doi": "10.5220/0014649700004058", "title": "Large Language Models for Quality Control of Large Language Models", "publicationYear": 2026, "publicationDate": "2026", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the 14th International Conference on Model-Based Software and Systems Engineering", "volume": null, "issue": null, "page": "150-161", "issn": null, "isbn": null, "authors": "Preethika Chandrasekaran, Imron Shajahan, Saran Sankaran, Benjamin Nast, Kurt Sandkuhl", "authorCount": 5, "firstAuthorAffiliation": "Institute of Computer Science, University of Rostock, Albert-Einstein-Str. 22, 18059 Rostock, Germany", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0014649700004058", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1109/acet67282.2025.11430384", "doi": "10.1109/acet67282.2025.11430384", "title": "On the Interpretability of Transformer Based Large Language Models", "publicationYear": 2025, "publicationDate": "2025-11-21", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 2nd International Conference on Advanced Computing and Emerging Technologies (ACET)", "volume": null, "issue": null, "page": "1-6", "issn": null, "isbn": null, "authors": "Aarush Sharma, Lavika Goel, VK Panchal", "authorCount": 3, "firstAuthorAffiliation": "Meerut institute of engineering and technology,Computer Science and Engineering,Meerut,India", "isReferencedByCount": 0, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/acet67282.2025.11430384", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1038/s41598-026-43507-7", "doi": "10.1038/s41598-026-43507-7", "title": "Transparent AI for mathematics: transformer-based large language models for mathematical entity relationship extraction with XAI", "publicationYear": 2026, "publicationDate": "2026-03-11", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Scientific Reports", "volume": "16", "issue": "1", "page": null, "issn": "2045-2322", "isbn": null, "authors": "Tanjim Taharat Aurpa", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 35, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/s41598-026-43507-7", "pdfUrl": "https://www.nature.com/articles/s41598-026-43507-7.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1201/9781003517245-3", "doi": "10.1201/9781003517245-3", "title": "Large Language Models", "publicationYear": 2024, "publicationDate": "2024-08-20", "type": "book-chapter", "publisher": "CRC Press", "containerTitle": "Large Language Models", "volume": null, "issue": null, "page": "70-108", "issn": null, "isbn": "9781003517245", "authors": "John Atkinson-Abutridy", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1201/9781003517245-3", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1101/2025.01.28.635344", "doi": "10.1101/2025.01.28.635344", "title": "Database-Augmented Transformer-Based Large Language Models Achieve High Accuracy in Mapping Gene-Phenotype Relationships", "publicationYear": 2025, "publicationDate": "2025-02-01", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Nicolas Matthew Suhardi, Anastasia Oktarina, Mathias P.G. Bostrom, Xu Yang, Vincentius Jeremy Suhardi", "authorCount": 5, "firstAuthorAffiliation": "Skeletal Health and Orthopedic Research Program, Hospital for Special Surgery, New York, NY 10021, USA", "isReferencedByCount": 0, "referenceCount": 26, "isOpenAccess": true, "licenseUrl": "https://www.biorxiv.org/about/FAQ#license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/2025.01.28.635344", "pdfUrl": null, "abstract": "Abstract Transformer-based large language models (LLMs) have demonstrated significant potential in the biological and medical fields due to their ability to effectively learn from large-scale, diverse datasets and perform a wide range of downstream tasks. However, LLMs are limited by issues such as information processing inaccuracies and data confabulation, which hinder their utility for literature searches and other tasks requiring accurate and comprehensive extraction of information from extensive scientific literature. In this study, we evaluated the performance of various LLMs in accurately retrieving peer-reviewed literature and mapping correlations between 102 genes and four phenotypes: bone formation, cartilage formation, fibrosis, and cell proliferation. Our analysis included standard transformer-based LLMs (ChatGPT4o and Gemini1.5 Pro), fine-tuned LLMs with dedicated custom databases containing peer-reviewed articles (SciSpace and ScholarAI), and fine-tuned LLMs without dedicated databases (PubMedGPT and ScholarGPT). Using human-curated gene-to-phenotype mappings as the ground truth, we found that fine-tuned LLMs with dedicated databases (SciSpace and ScholarAI) achieved high accuracy (&gt;80%) in gene-to-phenotype mapping. Additionally, these models were able to provide relevant peer-reviewed publications supporting each gene-to-phenotype correlation. These findings underscore the importance of database augmentation and finetuning in enhancing the reliability and utility of LLMs for biomedical research applications.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.2139/ssrn.5149339", "doi": "10.2139/ssrn.5149339", "title": "The Mathematics of Large Language Diffusion Models versus Large Language Autoregressive Models", "publicationYear": 2025, "publicationDate": "2025", "type": "posted-content", "publisher": "Elsevier BV", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Miquel Noguer I Alonso", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.5149339", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1007/979-8-8688-0515-8_4", "doi": "10.1007/979-8-8688-0515-8_4", "title": "Evaluating Models", "publicationYear": 2024, "publicationDate": "2024", "type": "book-chapter", "publisher": "Apress", "containerTitle": "Large Language Models Projects", "volume": null, "issue": null, "page": "133-190", "issn": null, "isbn": "9798868805141, 9798868805158", "authors": "Pere Martra", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/979-8-8688-0515-8_4", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1007/979-8-8688-0515-8", "doi": "10.1007/979-8-8688-0515-8", "title": "Large Language Models Projects", "publicationYear": 2024, "publicationDate": "2024", "type": "book", "publisher": "Apress", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9798868805141, 9798868805158", "authors": "Pere Martra", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/979-8-8688-0515-8", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/979-8-8688-0515-8.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.36548/jiip.2025.2.005", "doi": "10.36548/jiip.2025.2.005", "title": "Improving Narrative Coherence in Dense Video Captioning through Transformer and Large Language Models", "publicationYear": 2025, "publicationDate": "2025-06-03", "type": "journal-article", "publisher": "Inventive Research Organization", "containerTitle": "Journal of Innovative Image Processing", "volume": "7", "issue": "2", "page": "333-361", "issn": "2582-4252", "isbn": null, "authors": "Dvijesh Bhatt, Priyank Thakkar", "authorCount": 2, "firstAuthorAffiliation": "Department of Computer Science and Engineering, Institute of Technology, Nirma University, Ahmedabad", "isReferencedByCount": 3, "referenceCount": 53, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.36548/jiip.2025.2.005", "pdfUrl": "https://irojournals.com/iroiip/article/download/783/696", "abstract": "Dense video captioning aims to identify events within a video and generate natural language descriptions for each event. Most existing approaches adhere to a two-stage framework consisting of an event proposal module and a caption generation module. Previous methodologies have predominantly employed convolutional neural networks and sequential models to describe individual events in isolation. However, these methods limit the influence of neighboring events when generating captions for a specific segment, often resulting in descriptions that lack coherence with the broader storyline of the video. To address this limitation, we propose a captioning module that leverages both Transformer architecture and a Large Language Model (LLM). A convolutional and LSTM-based proposal module is used to detect and localize events within the video. An encoder-decoder-based Transformer model generates an initial caption for each proposed event. Additionally, we introduce a Large Language Model (LLM) that takes the set of individually generated event captions as input and produces a coherent, multi-sentence summary. This summary captures cross-event dependencies and provides a contextually unified and narratively rich description of the entire video. Extensive experiments on the ActivityNet dataset demonstrate that the proposed model, Transformer-LLM based Dense Video Captioning (TL-DVC), achieves a 9.22% improvement over state-of-the-art models, increasing the Meteor score from 11.28 to 12.32.", "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1007/979-8-8688-0540-0_1", "doi": "10.1007/979-8-8688-0540-0_1", "title": "Evolution and Significance of Large Language Models", "publicationYear": 2024, "publicationDate": "2024", "type": "book-chapter", "publisher": "Apress", "containerTitle": "Introduction to Python and Large Language Models", "volume": null, "issue": null, "page": "1-57", "issn": null, "isbn": "9798868805394, 9798868805400", "authors": "Dilyan Grigorov", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/979-8-8688-0540-0_1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1109/isscc49657.2024.10454330", "doi": "10.1109/isscc49657.2024.10454330", "title": "20.5 C-Transformer: A 2.6-18.1μJ/Token Homogeneous DNN-Transformer/Spiking-Transformer Processor with Big-Little Network and Implicit Weight Generation for Large Language Models", "publicationYear": 2024, "publicationDate": "2024-02-18", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2024 IEEE International Solid-State Circuits Conference (ISSCC)", "volume": null, "issue": null, "page": "368-370", "issn": null, "isbn": null, "authors": "Sangyeob Kim, Sangjin Kim, Wooyoung Jo, Soyeon Kim, Seongyon Hong, Hoi-Jun Yoo", "authorCount": 6, "firstAuthorAffiliation": "Korea Advanced Institute of Science and Technology,Daejeon,Korea", "isReferencedByCount": 39, "referenceCount": 9, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/isscc49657.2024.10454330", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1145/3644116.3644226", "doi": "10.1145/3644116.3644226", "title": "Research and Application of Large Language Models in HealthcareCurrent Development of Large Language Models in the Healthcare FieldA Framework for Applying Large Language Models and the Opportunities and Challenges of Large Language Models in Healthcare: A Framework for Applying Large Language Models and the Opportunities and Challenges of Large Language Models in Healthcare", "publicationYear": 2023, "publicationDate": "2023-10-20", "type": "proceedings-article", "publisher": "ACM", "containerTitle": "Proceedings of the 2023 4th International Symposium on Artificial Intelligence for Medicine Science", "volume": null, "issue": null, "page": "664-670", "issn": null, "isbn": null, "authors": "Chunfang Zhou, Qingyue Gong, Jinyang Zhu, Huidan Luan", "authorCount": 4, "firstAuthorAffiliation": "School of Artificial Intelligence and Information Technology, Nanjing University of Chinese Medicine, China", "isReferencedByCount": 1, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": "https://www.acm.org/publications/policies/copyright_policy#Background", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1145/3644116.3644226", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1007/978-981-95-1050-4_18", "doi": "10.1007/978-981-95-1050-4_18", "title": "Symbolic Constraint-Solving Capabilities of Transformer Large Language Models", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Springer Nature Singapore", "containerTitle": "Proceedings of 1st GENZERO Workshop", "volume": null, "issue": null, "page": "147-154", "issn": null, "isbn": "9789819510498, 9789819510504", "authors": "Leyan Pan, Chris Esposo, Jacob Abernethy, Vijay Ganesh, Wenke Lee", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 5, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "Technology Innovation Institute (TII) - Abu Dhabi", "funderIds": null, "url": "https://doi.org/10.1007/978-981-95-1050-4_18", "pdfUrl": null, "abstract": "Abstract The empirical success of Transformer-based Large Language Models (LLMs) has elicited significant interest in their application for security domains such as formal verification and program analysis. However, their application in formal domains, such as formal verification and program analysis, is constrained by the lack of mechanical understanding and the risk of hallucinations. To address these challenges, we present a robust theoretical construction establishing that transformer-LLMs with CoT can solve an NP-Hard logical reasoning problem, specifically 3-SAT. Our construction provides theoretical guarantees that these models can either simulate the deductive search processes of SAT-solving or probabilistically generate correct solutions as the most likely completion. Empirically, we demonstrate that transformers can generalize these procedures across different formula distributions, reinforcing their potential for reliable formal reasoning.", "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1201/9781003669012-4", "doi": "10.1201/9781003669012-4", "title": "Large Language Models in Chemistry", "publicationYear": 2025, "publicationDate": "2025-12-18", "type": "book-chapter", "publisher": "CRC Press", "containerTitle": "Large Language Models for Chemists", "volume": null, "issue": null, "page": "49-67", "issn": null, "isbn": "9781003669012", "authors": "Zhiling Zheng", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1201/9781003669012-4", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1201/9781003595533-3", "doi": "10.1201/9781003595533-3", "title": "Large Language Models", "publicationYear": 2025, "publicationDate": "2025-02-27", "type": "book-chapter", "publisher": "Chapman and Hall/CRC", "containerTitle": "Concept Drift in Large Language Models", "volume": null, "issue": null, "page": "14-22", "issn": null, "isbn": "9781003595533", "authors": "Ketan Sanjay Desale", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1201/9781003595533-3", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sXpd57pG3k5WBybtZ", "_dataset_id": "qfe2K10al8pHlHiyK"}
{"paperId": "10.1253/circj.cj-15-0857", "doi": "10.1253/circj.cj-15-0857", "title": "“The Third Man” in Heart Failure – Heart Failure With Reduce Ejection Fraction Evolved From Heart Failure With Preserved Ejection Fraction –", "publicationYear": 2015, "publicationDate": "2015", "type": "journal-article", "publisher": "Japanese Circulation Society", "containerTitle": "Circulation Journal", "volume": "79", "issue": "10", "page": "2108-2109", "issn": "1346-9843, 1347-4820", "isbn": null, "authors": "Kazuhiro Yamamoto", "authorCount": 1, "firstAuthorAffiliation": "Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University", "isReferencedByCount": 1, "referenceCount": 14, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1253/circj.cj-15-0857", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1253/circj.cj-15-0016", "doi": "10.1253/circj.cj-15-0016", "title": "Statins Beneficial for Heart Failure With Preserved Ejection Fraction But Not Heart Failure With Reduced Ejection Fraction?", "publicationYear": 2015, "publicationDate": "2015", "type": "journal-article", "publisher": "Japanese Circulation Society", "containerTitle": "Circulation Journal", "volume": "79", "issue": "3", "page": "508-509", "issn": "1346-9843, 1347-4820", "isbn": null, "authors": "Nobuyuki Ohte, William C. Little", "authorCount": 2, "firstAuthorAffiliation": "Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences", "isReferencedByCount": 7, "referenceCount": 13, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1253/circj.cj-15-0016", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circ.144.suppl_1.13703", "doi": "10.1161/circ.144.suppl_1.13703", "title": "Abstract 13703: Outpatient Cardiac Rehabilitation Reduces Heart Failure Re-Hospitalization in Patient With Heart Failure With Reduced Ejection Fraction When Compared to Patients With Heart Failure With Preserved Ejection Fraction", "publicationYear": 2021, "publicationDate": "2021-11-16", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "144", "issue": "Suppl_1", "page": null, "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "KELECHI EMMANUEL, Halimat Lawal, Guillermo Valenzuela, Yijin Wert", "authorCount": 4, "firstAuthorAffiliation": "Internal Medicine, UPMC Harrisburg, Harrisburg, PA", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circ.144.suppl_1.13703", "pdfUrl": null, "abstract": "Introduction: Cardiac rehabilitation has been increasingly recognized as an integral part in the management of patients with congestive heart failure. It has been shown to improve the quality of life in this patient population. However, It is unknown how much cardiac rehabilitation reduces heart failure hospitalizations in patients with heart failure with reduced ejection fraction (HFrEF) versus heart failure with preserved ejection fraction (HFpEF). Hypothesis: We hypothesize that outpatient cardiac rehabilitation is associated with reduced re-hospitalization for heart failure symptoms in patients with heart failure with HFrEF when compared with patients with HFpEF. Methods: We retrospectively analyzed data from 128 heart failure patients enrolled in an outpatient cardiac rehabilitation center from January 2015 to December 2020. The number of heart failure re-hospitalizations was measured in each of these patients. A Student t-test was used to analyze the difference between the two groups, while fisher’s test or chi square was used to analyze categorical variables. Results: Among the 128 patients enrolled in the outpatient cardiac rehabilitation center, age 68.1+-14 years, 63 (57.1%) were males. There were 70 patients (54.6%) in the HFrEF group and 58 (55.28%) in the HFpEF group. Hospitalization for acute exacerbation of heart failure symptoms was lower in the patients with HFrEF when compared with patients with HFpEF (41.3% vs 70.69% p value &lt;0.0009). Conclusion: Outpatient cardiac rehabilitation program is associated with reduced hospitalization for heart failure symptoms in patients with HFrEF when compared to patients with HFpEF.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/cir.151.suppl_1.p1084", "doi": "10.1161/cir.151.suppl_1.p1084", "title": "Abstract P1084: Association of Body Composition and Incident Heart Failure and Heart Failure with Preserved Ejection Fraction and Heart Failure with Reduced Ejection Fraction in postmenopausal women", "publicationYear": 2025, "publicationDate": "2025-03-11", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "151", "issue": "Suppl_1", "page": null, "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "Charles Eaton, mir mad madani, Connor Miller, Andrew Odegaard, Michael LaMonte", "authorCount": 5, "firstAuthorAffiliation": "Charles Eaton, Plymouth, Massachusetts, United States", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/cir.151.suppl_1.p1084", "pdfUrl": null, "abstract": "Background: As the US population ages, Heart Failure (HF) is reaching epidemic proportions, with heart failure with preserved ejection fraction (HFpEF) placing a particular burden on elderly women. While the association of obesity with the risk of heart failure is well established, the role of visceral adiposity and other measures of body composition have had limited research. Methods: A cohort of 10,527 postmenopausal women, mean age 63.3 (7.4) at baseline had DXA measures of VAT area ( cm 2 ), SAT area (cm 2 ), VAT/SAT ratio, Fat mass(kg), Lean mass (kg), % body fat and BMI (kg/m 2 ) and were followed for 16.7 years with 852 cases of incident HF . A sub-cohort of 3528 women were followed for the same period were evaluated for adjudicated HFpEF and HFrEF with 116 cases of HFpEF and 107 cases of HFrEF. We evaluate the association of the above body composition variables using multiple variable cox proportional hazards models (see tables below) .We also evaluated a comprehensive model including all sociodemographic and lifestyle variables as well as potential confounders/mediators of medical co-morbidities. Results: Both quartile and continuous measures of VAT, SAT, VAT/SAT ratio, Fat mass, lean mass, and BMI were associated with increased risk of HF and HFpEF with stronger associations with HFpEF but not HFrEF in our main model. The comprehensive model including potential mediators showed persistent but diminished associations for VAT, VAT/SAT ratio, Fat mass, Lean mass, and BMI but not SAT or %body fat. Time varying measures of VAT, VAT/SAT ratio showed persistent and stronger associations than baseline measures for HF and HFpEF but not HFrEF. Competing risk models for death and HF subtype when evaluating HFpEF or HFrEF showed similar but slightly attenuated results. Conclusion: Visceral Fat and VAT/SAT ratio, Fat mass, and Lean mass are associated with increased risk of HF and HFpEF but not HFrEF in this cohort of elderly women. Whether new treatments for weight loss that reduce visceral fat will reduce the risk of HF and HFpEF is worthy of future research.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.112.972638", "doi": "10.1161/circheartfailure.112.972638", "title": "Letter by Nunez et al Regarding Article, “Longitudinal Changes in Ejection Fraction in Heart Failure Patients With Preserved and Reduced Ejection Fraction”", "publicationYear": 2013, "publicationDate": "2013-03", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "6", "issue": "2", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Eduardo Nunez, Juan Sanchis, Julio Nunez", "authorCount": 3, "firstAuthorAffiliation": "Servicio de CardiologíaHospital Clínico Universitario, INCLIVAUniversitat de ValenciaValencia, Spain", "isReferencedByCount": 1, "referenceCount": 5, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.112.972638", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.115.002962", "doi": "10.1161/circheartfailure.115.002962", "title": "Changes in Left Ventricular Ejection Fraction Predict Survival and Hospitalization in Heart Failure With Reduced Ejection Fraction", "publicationYear": 2016, "publicationDate": "2016-10", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "9", "issue": "10", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Khadijah Breathett, Larry A. Allen, James Udelson, Gordon Davis, Michael Bristow", "authorCount": 5, "firstAuthorAffiliation": "From the Division of Cardiology, University of Colorado, Aurora (K.B., L.A.A., M.B.); Division of Cardiology, Tufts Medical Center, Boston, MA (J.U.); and ARCA Biopharma, Westminster, CO (G.D., M.B.).", "isReferencedByCount": 111, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.115.002962", "pdfUrl": null, "abstract": "Background— Left ventricular remodeling, as commonly measured by left ventricular ejection fraction (LVEF), is associated with clinical outcomes. Although change in LVEF over time should reflect response to therapy and clinical course, serial measurement of LVEF is inconsistently performed in observational settings, and the incremental prognostic value of change in LVEF has not been well characterized. Methods and Results— The β-Blocker Evaluation of Survival Trial measured LVEF by radionuclide ventriculography at baseline and at 3 and 12 months after randomization. We built a series of multivariable models with 16 clinical parameters plus change in LVEF for predicting 4 major clinical end points, including the trial’s primary end point of all-cause mortality. Among 2484 patients with at least 1 follow-up LVEF, change in LVEF was the second most significant predictor (behind baseline creatinine) of all-cause mortality (adjusted hazard ratio for improvement in LVEF by ≥5 U responder versus nonresponder [95% confidence intervals] for all-cause mortality=0.62 [0.52–0.73]). Other end points, including heart failure hospitalization or the composite of all-cause mortality and heart failure hospitalization, yielded similar results. LVEF change ≥5 U was associated with a modest increase in discrimination when added to traditional predictors and was predictive of outcomes in both the bucindolol and placebo treatment groups. LVEF change as a predictor of outcomes was affected by sex and race, with evidence that LVEF improvement is associated with less survival benefit in African Americans and women. Conclusions— Serial evaluation for LVEF change predicts both survival and heart failure hospitalization and provides a dynamic/real-time measure of prognosis in heart failure with reduced LVEF. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00000560.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circ.144.suppl_1.9704", "doi": "10.1161/circ.144.suppl_1.9704", "title": "Abstract 9704: Mortality and Readmissions in Patients With Heart Failure With Preserved Ejection Fraction versus Heart Failure With Reduced Ejection Fraction", "publicationYear": 2021, "publicationDate": "2021-11-16", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "144", "issue": "Suppl_1", "page": null, "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "Yaser Carcora, Amy Gravely, Venkatakrishna N Tholakanahalli, Selcuk Adabag", "authorCount": 4, "firstAuthorAffiliation": "Dept of Cardiology, Univ of Minnesota, Minneapolis, MN", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circ.144.suppl_1.9704", "pdfUrl": null, "abstract": "Introduction: Heart failure (HF) is a large public health problem with a 12 month mortality rate of 22% and a 30 day standardized readmission rate of 23%. We aimed to determine the differences in readmissions and long-term survival in patients with Heart Failure with Preserved Ejection Fraction (HFpEF) compared to Heart Failure with Reduced Ejection Fraction (HFrEF). Hypothesis: Heart Failure patients will have high mortality regardless of ejection fraction, with similar readmission rates across groups. Methods: We studied 3200 consecutive patients discharged from the hospital with a primary diagnosis of HF from October 2015 to March 2019. Patients were classified as HFpEF (EF &gt;50%) or HFrEF (EF&lt;50%). Results: At baseline, patients had a mean age of 75.0±10.3 and 97.9% were male. Patients with HFrEF were more likely to have coronary artery disease, myocardial infraction, diabetes, and more likely to be on beta blockers and ACE inhibitors (all p&lt;0.0001)(Table 1). Over 11.2±11.3 months of follow-up, patients with HFrEF were more likely to be readmitted (49.2 vs 37.5%, p&lt;0.0001)(Table 2). However, 3-year cumulative all cause death was no different between groups (34.6% vs. 34%; p=0.512) (Figure). Conclusions: Patients with HFrEF were more likely to have readmissions than those with HFpEF. But the long-term mortality was unacceptably high in both groups.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.111.966366", "doi": "10.1161/circheartfailure.111.966366", "title": "Longitudinal Changes in Ejection Fraction in Heart Failure Patients With Preserved and Reduced Ejection Fraction", "publicationYear": 2012, "publicationDate": "2012-11", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "5", "issue": "6", "page": "720-726", "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Shannon M. Dunlay, Véronique L. Roger, Susan A. Weston, Ruoxiang Jiang, Margaret M. Redfield", "authorCount": 5, "firstAuthorAffiliation": "From the Division of Cardiovascular Diseases in the Department of Internal Medicine (S.M.D., V.L.R., M.M.R.), and Department of Health Sciences Research (V.L.R., S.A.W., R.J.), Mayo Clinic, Rochester, Minnesota.", "isReferencedByCount": 279, "referenceCount": 39, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.111.966366", "pdfUrl": null, "abstract": "Background— Heart failure (HF) can occur in patients with preserved (HFpEF, EF≥50%) or reduced (HFrEF, EF&lt;50%) ejection fraction (EF), but changes in EF after HF diagnosis are not well described. Methods and Results— Among a community cohort of incident HF patients diagnosed from 1984 to 2009 in Olmsted County, Minnesota, we obtained all EFs assessed by echocardiography from initial HF diagnosis until death or last follow-up through March 2010. Mixed effects models fit a unique linear regression line for each person using serial EF data. Compiled results allowed estimates of the change in EF over time in HFpEF and HFrEF. Among 1233 HF patients (48.3% male, mean age 75.0 years, mean follow-up 5.1 years), 559 (45.3%) had HFpEF at diagnosis. In HFpEF, on average, EF decreased by 5.8% over 5 years ( P &lt;0.001) with greater declines in older individuals and those with coronary disease. Conversely, EF increased in HFrEF (average increase 6.9% over 5 years, P &lt;0.001). Greater increases were noted in women, younger patients, individuals without coronary disease, and those treated with evidence-based medications. Overall, 39% of HFpEF patients had an EF&lt;50% and 39% of HFrEF patients had an EF≥50% at some point after diagnosis. Decreases in EF over time were associated with reduced survival whereas increases in EF were associated with improved survival. Conclusions— These data suggest that progressive contractile dysfunction may contribute to the pathophysiology of HFpEF. Prospective longitudinal studies are needed to confirm these observations and establish the mechanism and clinical relevance of decline in EF over time in HFpEF.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.115.002826", "doi": "10.1161/circheartfailure.115.002826", "title": "Heart Failure and Midrange Ejection Fraction", "publicationYear": 2016, "publicationDate": "2016-04", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "9", "issue": "4", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Wilson Nadruz, Erin West, Mário Santos, Hicham Skali, John D. Groarke, Daniel E. Forman, Amil M. Shah", "authorCount": 7, "firstAuthorAffiliation": "From the Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA (W.N., E.W., H.S., J.D.G., A.M.S.); Department of Internal Medicine, University of Campinas, Campinas, Brazil (W.N.); Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine of University of Porto, Porto, Portugal (M.S.); and Department of Medicine, Section of Geriatric Cardiology, University of Pittsburgh Medical Center, PA (D.E.F.).", "isReferencedByCount": 88, "referenceCount": 22, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.115.002826", "pdfUrl": null, "abstract": "Background— Evidence-based therapies for heart failure (HF) differ significantly according to left ventricular ejection fraction (LVEF). However, few data are available on the phenotype and prognosis of patients with HF with midrange LVEF of 40% to 55%, and the impact of recovered systolic function on the clinical features, functional capacity, and outcomes of this population is not known. Methods and Results— We studied 944 patients with HF who underwent clinically indicated cardiopulmonary exercise testing. The study population was categorized according to LVEF as follows: HF with reduced LVEF (HFrEF; LVEF&lt;40%; n=620); HF with midrange ejection fraction and no recovered ejection fraction (LVEF was consistent between 40% and 55%; n=107); HF with recovered midrange ejection fraction (LVEF, 40%–55% but previous LVEF&lt;40%; n=170); and HF with preserved LVEF (HFpEF; LVEF&gt;55%; n=47). HF with midrange ejection fraction and no recovered ejection fraction and HF with recovered midrange ejection fraction had similar clinical characteristics, which were intermediate between those of HFrEF and HFpEF, and comparable values of predicted peak oxygen consumption and minute-ventilation/carbon dioxide production slope, which were better than HFrEF and similar to HFpEF. After a median of 4.4 (2.9–5.7) years, there were 253 composite events (death, left ventricular assistant device implantation, or transplantation). In multivariable Cox-regression analysis, HF with recovered midrange ejection fraction had lower risk of composite events than HFrEF (hazard ratio, 0.25; 95% confidence interval, 0.13–0.47) and HF with midrange ejection fraction and no recovered ejection fraction (hazard ratio, 0.31; 95% confidence interval, 0.15–0.67), and similar prognosis when compared with HFpEF. In contrast, HF with midrange ejection fraction and no recovered ejection fraction tended to show intermediate risk of outcomes in comparison with HFpEF and HFrEF, albeit not reaching statistical significance in fully adjusted analyses. Conclusions— Patients with HF with midrange LVEF demonstrate a distinct clinical profile from HFpEF and HFrEF patients, with objective measures of functional capacity similar to HFpEF. Within the midrange LVEF HF population, recovered systolic function is a marker of more favorable prognosis.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.113.000154", "doi": "10.1161/circheartfailure.113.000154", "title": "Response to Letter Regarding Article, “Longitudinal Changes in Ejection Fraction in Heart Failure Patients With Preserved and Reduced Ejection Fraction”", "publicationYear": 2013, "publicationDate": "2013-03", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "6", "issue": "2", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Shannon M. Dunlay, Véronique L. Roger, Susan A. Weston, Ruoxiang Jiang, Margaret M. Redfield", "authorCount": 5, "firstAuthorAffiliation": "Division of Cardiovascular DiseasesDepartment of Internal MedicineMayo ClinicRochester, MN", "isReferencedByCount": 1, "referenceCount": 3, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.113.000154", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circ.135.suppl_1.mp031", "doi": "10.1161/circ.135.suppl_1.mp031", "title": "Abstract MP031: Prospective Association of Obstructive Sleep Apnea Risk Factors with Heart Failure with Preserved Ejection Fraction and Not Heart Failure with Reduced Ejection Fraction in Postmenopausal Women", "publicationYear": 2017, "publicationDate": "2017-03-07", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "135", "issue": "suppl_1", "page": null, "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "Patrick Koo, Umama Gorsi, Mary Roberts, Charles Eaton", "authorCount": 4, "firstAuthorAffiliation": "Erlanger Health System, Univ of Tennessee College of Medicine Chattanooga, Chattanooga, TN", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circ.135.suppl_1.mp031", "pdfUrl": null, "abstract": "Background: The relationship between obstructive sleep apnea (OSA) and heart failure (HF) has been under-researched especially in postmenopausal women. We therefore evaluated relationship between OSA risk factors and HFpEF and HFrEF in post-menopausal women. Methods: We performed a prospective analysis of a subset of participants who had adjudicated heart failure outcomes (n=42,362) in the Women Health Initiative Observational, Clinical Trial, and Extension Studies (1998-Present). The cohort was followed over an average of 13.4 years. Inverse probability weighting was employed to account for potential selection bias. Cox proportional hazards regression was used to examine the association between OSA risk factors and time to first hospitalized HF. Type of heart failure was determined using the ejection fraction (EF) obtained from 2D echocardiography. EF of ≥45% was categorized as HFpEF, and EF of &lt; 45% was categorized as HFrEF. Models were adjusted for age, race/ethnicity, education, income, marital status, systolic blood pressure, waist-to-hip ratio, diabetes, coronary heart disease, atrial fibrillation, use of hormone replacement therapy, use of sleep medications, modified Charlson comorbidity index, smoking, alcohol consumption, physical activity, and hysterectomy. We also created an OSA summary score (obesity, snoring, poor sleep quality, sleep fragmentation, daytime sleepiness, and hypertension) based on the Berlin questionnaire, which reliably predicts OSA, to examine its relationship with HF. Results: Of the 42,362 women, 1,054 (2.49%) had preserved EF, and 631 (1.49%) had reduced EF. Four of the 6 risk factors (obesity (HR=1.51, 95% CI 1.29-1.76), snoring (HR=1.23, 95% CI 1.04-1.45), sleep fragmentation (HR=1.15, 95% CI 1.01-1.31), and hypertension (HR=1.46, 95% CI 1.31-1.62)) were associated HFpEF after adjusting for confounders. Each additional OSA risk factor in an OSA summary score compared to no risk factors significantly increased the risk of HFpEF in a dose-response fashion (HR=1.36, 1.61, 2.01, 1.97, 2.02, and 2.74 for scores of 1-6, respectively; P trend &lt;0.001) and not HFrEF (P trend =0.26). Only hypertension was associated with HFrEF (HR=1.39, 95% CI 1.22-1.60). Conclusion: Having more OSA risk factors increases the risk of HFpEF but not HFrEF in postmenopausal women. Early recognition and management of OSA risk factors may play an important role in reducing risk of HFpEF in this population.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.120.007840", "doi": "10.1161/circheartfailure.120.007840", "title": "Right Heart Phenotype in Heart Failure With Preserved Ejection Fraction", "publicationYear": 2021, "publicationDate": "2021-04", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "14", "issue": "4", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Marco Guazzi, Robert Naeije", "authorCount": 2, "firstAuthorAffiliation": "Department of Biological Sciences, University of Milano, Italy (M.G.).", "isReferencedByCount": 47, "referenceCount": 88, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.120.007840", "pdfUrl": null, "abstract": "The health burden of heart failure with preserved ejection fraction is increasingly recognized. Despite improvements in diagnostic algorithms and established knowledge on the clinical trajectory, effective treatment options for heart failure with preserved ejection fraction remain limited, mainly because of the high mechanistic heterogeneity. Diagnostic scores, big data, and phenomapping categorization are proposed as key steps needed for progress. In the meantime, advancements in imaging techniques combined to high-fidelity pressure signaling analysis have uncovered right ventricular dysfunction as a mediator of heart failure with preserved ejection fraction progression and as major independent determinant of poor outcome. This review summarizes the current understanding of the pathophysiology of right ventricular dysfunction in heart failure with preserved ejection fraction covering the different right heart phenotypes and offering perspectives on new treatments targeting the right ventricle in its function and geometry.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1253/circj.cj-11-0568", "doi": "10.1253/circj.cj-11-0568", "title": "Prognostic Impact of Myocardial Interstitial Fibrosis in Non-Ischemic Heart Failure - Comparison Between Preserved and Reduced Ejection Fraction Heart Failure -", "publicationYear": 2011, "publicationDate": "2011", "type": "journal-article", "publisher": "Japanese Circulation Society", "containerTitle": "Circulation Journal", "volume": "75", "issue": "11", "page": "2605-2613", "issn": "1346-9843, 1347-4820", "isbn": null, "authors": "Tatsuo Aoki, Yoshihiro Fukumoto, Koichiro Sugimura, Minako Oikawa, Kimio Satoh, Makoto Nakano, Masaharu Nakayama, Hiroaki Shimokawa", "authorCount": 8, "firstAuthorAffiliation": "Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine", "isReferencedByCount": 160, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1253/circj.cj-11-0568", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/hhf.0000000000000036", "doi": "10.1161/hhf.0000000000000036", "title": "Correction to: Sex-Related Differences in Heart Failure With Preserved Ejection Fraction", "publicationYear": 2020, "publicationDate": "2020-01", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "13", "issue": "1", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/hhf.0000000000000036", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.119.005956", "doi": "10.1161/circheartfailure.119.005956", "title": "Phenotypic Persistence in Heart Failure With Preserved Ejection Fraction", "publicationYear": 2019, "publicationDate": "2019-03", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "12", "issue": "3", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Walter J. Paulus", "authorCount": 1, "firstAuthorAffiliation": "Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, The Netherlands.", "isReferencedByCount": 8, "referenceCount": 15, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.119.005956", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circ.150.suppl_1.4146021", "doi": "10.1161/circ.150.suppl_1.4146021", "title": "Abstract 4146021: Post transcatheter aortic valve replacement outcomes among patients with heart failure with preserved ejection fraction versus heart failure with reduced ejection fraction.", "publicationYear": 2024, "publicationDate": "2024-11-12", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "150", "issue": "Suppl_1", "page": null, "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "Vikash Jaiswal, Muhammad Hanif, Akash Jaiswal, Adriana Mares, FNU Sundas, Ramesh Daggubati, Kendra Grubb", "authorCount": 7, "firstAuthorAffiliation": "JCCR Cardiology Research, Jaunpur, India", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circ.150.suppl_1.4146021", "pdfUrl": null, "abstract": "Background: Heart failure with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction (HFrEF) is a common comorbidity in patients undergoing transcatheter aortic valve replacement (TAVR). However, post-TAVR outcomes among HFpEF and HFrEF patients have not been well studied. Objective: This study aims to investigate the clinical outcomes post-TAVR among patients with HFrEF vs. HFpEF. Methods: The TriNeTX Global Collaborative Network research database was used to identify patients aged ≥18 years from January 2005 to May 2023. Patients were categorized into two groups: HFpEF and a control group with HFrEF, with both groups of patients undergoing TAVR and followed for 1-month and 1-year. Propensity score-matched analysis (PSM) (1:1) was performed on age, gender, race, body mass index, hypertension, diabetes mellitus, chronic kidney disease, smoking status, hemoglobin level, low density lipid (LDL) level, and various drugs including ACEi, ARBi, beta-blockers, SGLT2i and statins. Primary outcome was all-cause mortality (ACM), while secondary outcomes were acute myocardial infarction (AMI), ischemic stroke, hemorrhagic stroke, major bleeding and major adverse cardiovascular event (MACE) (composite of ACM, AMI and ischemic stroke). Results: After 1:1 propensity score matching ( Figure 1 ), the study cohort comprised of 11, 982 patients in HFpEF with TAVR and 11, 982 patients in the control group. The mean age of patients in HFpEF and HFrEF was 81.7 and 81.5 years, respectively. PSM analysis showed that post-TAVR outcomes among HFpEF patients were significantly associated with lower risk of ACM after 1-month (RR, 0.88 (95%CI: 0.707-0.953), P =0.009), and after 1-year (RR, 0.93 (95% CI: 0.87-0.99), P =0.041) compared with the HFrEF group. A similar trend was observed with a significant reduction in the risk of MACE after 1-month (RR, 0.86, (95% CI: 0.74-0.99), P =0.043), however, it was non-significant after 1-year (RR, 0.942 (95% CI: 0.881-1.007), P =0.077). However, the risk of AMI, ischemic stroke, hemorrhagic stroke, major bleeding both at 1-month and 1-year follow up were comparable between the HFpEF and HFrEF post-TAVR. Conclusion: In patients with HFpEF post-TAVR, there was a significant decrease in ACM at 1-month and 1-year, while there was a significant reduction in MACE only at 1-month. Further investigation is warranted to determine whether HFpEF has better clinical outcomes than patients with HFrEF.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1253/circj.cj-18-0663", "doi": "10.1253/circj.cj-18-0663", "title": "Monitoring Changes in Ejection Fraction in Patients With Heart Failure and Mid-Range Ejection Fraction", "publicationYear": 2018, "publicationDate": "2018-07-25", "type": "journal-article", "publisher": "Japanese Circulation Society", "containerTitle": "Circulation Journal", "volume": "82", "issue": "8", "page": "1991-1993", "issn": "1346-9843, 1347-4820", "isbn": null, "authors": "Masahiko Kato, Kazuhiro Yamamoto", "authorCount": 2, "firstAuthorAffiliation": "Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University", "isReferencedByCount": 0, "referenceCount": 13, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1253/circj.cj-18-0663", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.122.010252", "doi": "10.1161/circheartfailure.122.010252", "title": "Echocardiographic Features Beyond Ejection Fraction and Associated Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction", "publicationYear": 2023, "publicationDate": "2023-05", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "16", "issue": "5", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Anthony E. Peters, Robert M. Clare, Karen Chiswell, G. Michael Felker, Anita Kelsey, Robert Mentz, Adam D. DeVore", "authorCount": 7, "firstAuthorAffiliation": "Division of Cardiology, Duke University School of Medicine, Durham, NC (A.E.P., G.M.F., A.K., R.M., A.D.D.).", "isReferencedByCount": 6, "referenceCount": 47, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.122.010252", "pdfUrl": null, "abstract": "Background: Heart failure (HF) guidelines recommend assessment of left ventricular ejection fraction (LVEF) to classify patients and guide therapy implementation. However, LVEF alone may be insufficient to adequately characterize patients with HF, especially those with mildly reduced or preserved LVEF. Recommendations on additional testing are lacking, and there are limited data on use of echocardiographic features beyond LVEF in patients with heart failure with mildly reduced or preserved LVEF. Methods: In patients with HF with mildly reduced or preserved LVEF identified in a large US health care system, the association of the following metrics with mortality was evaluated: LV global longitudinal strain (LV GLS&gt;–16), left atrial volume index (&gt;28 mL/m 2 ), left ventricular hypertrophy (LVH), and E/e´&gt;13 and e´&lt;9. A multivariable model for mortality was constructed including age, sex, and key comorbidities followed by stepwise selection of echocardiographic features. Characteristics and outcomes of subgroups with normal versus abnormal LV GLS and LVEF were evaluated. Results: Among 2337 patients with complete echocardiographic data assessed between 2017 and 2020, the following features were associated with all-cause mortality on univariate analysis over 3 years of follow-up: E/e´+e´, LV GLS, left atrial volume index (all P &lt;0.01). In the multivariable model ( C -index=0.65), only abnormal LV GLS was independently associated with all-cause mortality (HR, 1.35 [95% CI, 1.11–1.63]; P =0.002). Among patients with LVEF&gt;55%, 498/1255 (40%) demonstrated abnormal LV GLS. Regardless of specific LVEF, patients with abnormal LV GLS demonstrated a higher burden of multiple comorbidities and higher event rates compared with patients with normal LV GLS. Conclusions: In a large, real-world HF with mildly reduced or preserved LVEF population, echocardiographic features, led by LV GLS, were associated with adverse outcomes irrespective of LVEF. A large proportion of patients demonstrate adverse myocardial function by LV GLS despite preserved LVEF and may represent a key cohort of interest for HF medical therapies and future clinical studies.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.117.003971", "doi": "10.1161/circheartfailure.117.003971", "title": "Pericardiectomy to Treat Heart Failure With Preserved Ejection Fraction", "publicationYear": 2017, "publicationDate": "2017-04", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "10", "issue": "4", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Martin M. LeWinter", "authorCount": 1, "firstAuthorAffiliation": "From the Cardiology Unit, University of Vermont, Burlington.", "isReferencedByCount": 2, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.117.003971", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circ.146.suppl_1.15630", "doi": "10.1161/circ.146.suppl_1.15630", "title": "Abstract 15630: Association of Frailty With 30- and 90-day Outcomes in Patients Admitted With Heart Failure With Reduced Ejection Fraction (hfref) and Heart Failure With Preserved Ejection Fraction (hfpef)", "publicationYear": 2022, "publicationDate": "2022-11-08", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "146", "issue": "Suppl_1", "page": null, "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "Sumitabh Singh, Neha Mulpuri, Nitin Kondamudi, Lin Zhong, Ambarish Pandey", "authorCount": 5, "firstAuthorAffiliation": "Dept of Internal Medicine, UTSW MEDICAL CENTER, Dallas, TX", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circ.146.suppl_1.15630", "pdfUrl": null, "abstract": "Background: Frailty is associated with adverse post-hospitalization outcomes among patients admitted with heart failure. Whether frailty associated risk of adverse events among HF patients differs by HF subtype (HFpEF vs. HFrEF) is not well-established. Methods: Using Medicare claims data, we identified patients newly hospitalized for HF in 2016 within a cohort of 5% fee-for-service Medicare beneficiaries and used ICD-10 codes to specify HF subtype. Frailty was quantified using the Hospital Frailty Risk Score (HFRS), which computes frailty using 109 ICD-10 codes within 3 months of the index HF hospitalization. The association of HFRS with risk of outcomes were assessed using adjusted Cox proportional hazard models and multiplicative interaction testing was performed for HF subtype and HFRS. Improvement in model discrimination with addition of HFRS was assessed using change in the C-statistic and the integrated discrimination improvement test (IDI). Results: The study cohort included 14,276 Medicare beneficiaries hospitalized for HF [mean age (SD), 79 (8.4); 53 % women; 88 % white], among them 6836 (48%) with HFpEF and 3586 (25%) with HFrEF. In adjusted Cox models, higher frailty burden was associated with greater risk of 30- and 90- day mortality among beneficiaries hospitalized for HFrEF and HFpEF (Table 1). For readmission outcomes, higher frailty burden was associated with a significantly higher risk of 30-day and 90-day readmission among patients with HFpEF but not HFrEF (p-interaction HFRS * HF subtypes = 0.03 for both, Table 1). Addition of HFRS significantly improve discrimination to predict readmission. [30-day readmission, IDI (95%CI) = 0.011 (0.006-0.016)]. Conclusion: Higher frailty burden is significantly associated with increased risk of mortality in patients with HFpEF and HFrEF. In contrast, frailty is more strongly associated with risk of readmission (30-day and 90-day) among patients with HFpEF only but not among HFrEF.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.109.932996", "doi": "10.1161/circheartfailure.109.932996", "title": "Factors Associated With Outcome in Heart Failure With Preserved Ejection Fraction", "publicationYear": 2011, "publicationDate": "2011-01", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "4", "issue": "1", "page": "27-35", "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Michel Komajda, Peter E. Carson, Scott Hetzel, Robert McKelvie, John McMurray, Agata Ptaszynska, Michael R. Zile, David DeMets, Barry M. Massie", "authorCount": 9, "firstAuthorAffiliation": "From the Pitie Salpetriere Hospital–University Pierre and Marie Curie Paris VI (M.K.), Paris, France; Georgetown University and Washington DC Veterans Affairs Medical Center (P.E.C.), Washington, DC; the Department of Biostatistics and Medical Informatics (S.H.), University of Wisconsin-Madison, Madison, Wis; Hamilton Health Sciences (R.M.), McMaster University, Hamilton, Ontario, Canada; British Heart Foundation Glasgow Cardiovascular Research Centre (J.M.), University of Glasgow, Glasgow, United...", "isReferencedByCount": 228, "referenceCount": 40, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.109.932996", "pdfUrl": null, "abstract": "Background— The determinants of prognosis in patients with heart failure and preserved ejection fraction (HF-PEF) are poorly documented. Methods and Results— We evaluated data from 4128 patients in the I-PRESERVE trial (Irbesartan in Heart Failure with Preserved Ejection Fraction Study). Multivariable Cox regression models were developed using 58 baseline demographic, clinical, and biological variables to model the primary outcome of all-cause mortality or cardiovascular hospitalization (1505 events), all-cause mortality (881 events), and HF death or hospitalization (716 events). Log N-terminal pro–B-type natriuretic peptide, age, diabetes mellitus, and previous hospitalization for HF were the most powerful factors associated with the primary outcome and with the HF composite. For all-cause mortality, log N-terminal pro–B-type natriuretic peptide, age, diabetes mellitus, and left ventricular EF were the strongest independent factors. Other independent factors associated with poor outcome included quality of life, a history of chronic obstructive lung disease, log neutrophil count, heart rate, and estimated glomerular filtration rate. The models accurately stratified the actual 3-year rate of outcomes from 8.1% to 59.9% (primary outcome) 2.7% to 36.5% (all-cause mortality), and 2.1% to 38.9% (HF composite) for the lowest to highest septiles of predicted risks. Conclusions— In a large sample of elderly patients with HF and preserved EF enrolled in I-Preserve, simple clinical, demographic, and biological variables were associated with outcome and identified subgroups at very high and very low risk of events. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00095238.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.110.959890", "doi": "10.1161/circheartfailure.110.959890", "title": "Body Mass Index and Adverse Cardiovascular Outcomes in Heart Failure Patients With Preserved Ejection Fraction", "publicationYear": 2011, "publicationDate": "2011-05", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "4", "issue": "3", "page": "324-331", "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Markus Haass, Dalane W. Kitzman, Inder S. Anand, Alan Miller, Michael R. Zile, Barry M. Massie, Peter E. Carson", "authorCount": 7, "firstAuthorAffiliation": "From the Department of Cardiology, Theresienkrankenhaus, Mannheim, Germany (M.H.); Wake Forest University School of Medicine, Winston-Salem, NC (D.W.K.); VA Medical Center, Minneapolis, MN (I.S.A.); University of Florida, Jacksonville, FL (A.M.); Ralph H. Johnson Veterans Affairs Medical Center and Medical University of South Carolina, Charleston, SC (M.R.Z.); University of California, San Francisco, and San Francisco VAMC, San Francisco, CA (B.M.M.); and Washington VAMC and Georgetown University,...", "isReferencedByCount": 303, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.110.959890", "pdfUrl": null, "abstract": "Background— Obesity is a major risk factor for incident heart failure (HF). Paradoxically, in HF with reduced left ventricular ejection fraction (HFREF), a high body mass index (BMI) appears to be beneficial. Approximately 50% of HF patients have a preserved left ventricular ejection fraction (HFPEF). However, there are few data regarding the relationship between BMI and outcomes in HFPEF. Methods and Results— Baseline characteristics and cardiovascular outcomes were assessed in the 4109 patients (mean age, 72 years; mean follow-up, 49.5 months) in the Irbesartan in HF with Preserved Ejection Fraction (I-PRESERVE) trial. Based on the BMI distribution, 5 BMI categories were defined: &lt;23.5, 23.5 to 26.4, 26.5 to 30.9, 31 to 34.9, and ≥35 kg/m 2 . Most patients (71%) had a BMI ≥26.5, 21% had a BMI between 23.5 and 26.4, and 8% had a BMI &lt;23.5 kg/m 2 . Patients with higher BMI were younger, more often women, and more likely to have hypertension and diabetes and higher left ventricular ejection fraction. Patients with BMI of 26.5 to 30.9 kg/m 2 had the lowest rate for the primary composite outcome (death or cardiovascular hospitalization) and were used as reference group. After adjustment for 21 risk variables including age, sex, and N-terminal pro-brain natriuretic peptide, the hazard ratio for the primary outcome was increased in patients with BMI &lt;23.5 (hazard ratio, 1.27; 95% confidence interval, 1.04 to 1.56; P =0.019) and in those with BMI ≥35 kg/m 2 (hazard ratio, 1.27; 95% confidence interval, 1.06 to 1.52; P =0.011) compared with the referent group. A similar relationship was found for all-cause mortality and for HF hospitalization. Conclusions— Obesity is common in HFPEF patients and is accompanied by multiple differences in clinical characteristics. Independent of other key prognostic variables, there was a U-shaped relationship, with the greatest rate of adverse outcomes in the lowest and highest BMI categories. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT000095238.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.113.000422", "doi": "10.1161/circheartfailure.113.000422", "title": "<i>Circulation: Heart Failure</i> Editors’ Picks", "publicationYear": 2013, "publicationDate": "2013-05", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "6", "issue": "3", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Robb D. Kociol", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.113.000422", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.116.003318", "doi": "10.1161/circheartfailure.116.003318", "title": "Heart Failure With a Better Ejection Fraction", "publicationYear": 2016, "publicationDate": "2016-07", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "9", "issue": "7", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Anupam Basuray, James C. Fang", "authorCount": 2, "firstAuthorAffiliation": "From the OhioHealth Heart &amp; Vascular Department, Riverside Methodist Hospital, Columbus (A.B.); and Division of Cardiovascular Medicine, University of Utah Health Sciences Center, Salt Lake City (J.C.F.).", "isReferencedByCount": 3, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.116.003318", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circulationaha.111.071696", "doi": "10.1161/circulationaha.111.071696", "title": "Heart Failure With Preserved Ejection Fraction", "publicationYear": 2011, "publicationDate": "2011-11-22", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "124", "issue": "21", "page": null, "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "James E. Udelson", "authorCount": 1, "firstAuthorAffiliation": "From the Division of Cardiology and the CardioVascular Center, Tufts Medical Center, Boston, MA.", "isReferencedByCount": 96, "referenceCount": 22, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circulationaha.111.071696", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1016/j.hlc.2018.06.094", "doi": "10.1016/j.hlc.2018.06.094", "title": "Characteristics and Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction Compared with Heart Failure with Reduced Ejection Fraction: Insights from the Victorian Cardiac Outcomes Registry Heart Failure Module", "publicationYear": 2018, "publicationDate": "2018", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Heart, Lung and Circulation", "volume": "27", "issue": null, "page": "S84-S85", "issn": "1443-9506", "isbn": null, "authors": "C. Tan, D. Dinh, A. Brennan, C. Reid, A. Driscoll, J. Lefkovits, D. Stub", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.hlc.2018.06.094", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circ.134.suppl_1.11839", "doi": "10.1161/circ.134.suppl_1.11839", "title": "Abstract 11839: Comparisons of Cardiopulmonary Exercise Testing Between Heart Failure With Reduced Ejection Fraction and Preserved Ejection Fraction", "publicationYear": 2016, "publicationDate": "2016-11-11", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "134", "issue": "suppl_1", "page": null, "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "Takamasa Sato, Yuki Kanno, Akiomi Yoshihisa, Yasuchika Takeishi", "authorCount": 4, "firstAuthorAffiliation": "Dept of Cardiovascular Medicine, Fukushima Med Univ, Fukushima, Japan", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circ.134.suppl_1.11839", "pdfUrl": null, "abstract": "Background: Parameters derived from cardiopulmonary exercise testing (CPET) are important prognostic markers, especially peak oxygen consumption (VO 2 ), the minute ventilation carbon dioxide production slope (VE/VCO 2 slope), exertional oscillatory ventilation (EOV) and oxygen uptake efficiency slope (OUES) in chronic heart failure (CHF). However, the significance of these parameters has not been examined in terms of left ventricular ejection fraction (EF). We aimed to compare the impacts of these exercise parameters on clinical outcomes between CHF patients with reduced EF (HFrEF) and preserved EF (HFpEF). Methods: We analyzed 1190 patients (969 males, mean age 61.0 years) with CHF who admitted to our hospital and performed CPET. We divided subjects into two groups: HFrEF (LVEF&lt;45%, n=655) and HFpEF (LVEF≥45%, n=535). We compared the independent factors to predict adverse composite cardiac events (cardiac deaths and rehospitalization due to worsening heart failure), cardiac deaths and all-cause deaths between HFrHF and HFpEF. Results: In the follow-up period (mean 1155 days), 407 adverse cardiac events (rehospitalization due to worsening heart failure and cardiac deaths), 172 cardiac deaths and 247 all-cause deaths were occurred. Kaplan-Meier analyses demonstrated that composite cardiac event rates, cardiac and all-cause mortalities were significantly higher in HFrEF than in HFpEF (P&lt;0.001, respectively). In Cox proportional hazard multivariate analyses, independent predictors of composite adverse events were peak VO 2 , VE/VCO 2 slope and OUES in HFrEF (P&lt;0.001, P&lt;0.001 and P=0.001, respectively), those of cardiac deaths were peak VO 2 , OUES and VE/VO 2 slope (P=0.002, P=0.005 and P=0.008, respectively), and those of all-cause deaths were peak VO 2 , OUES and VE/VCO 2 slope (P=0.001 and P=0.023 and P=0.041, respectively) in HFrEF. On the other hands, the independent predictors of composite adverse events were peak VO2 and VE/VCO2 slope (P&lt;0.001 and P=0.041), and those of cardiac deaths and all cause deaths were peak VO 2 in HFpEF (P&lt;0.001 and P=0.001, respectively). Conclusion: Impacts of these parameters were different between HFrEF and HFpEF based on several clinical outcomes.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.124.012187", "doi": "10.1161/circheartfailure.124.012187", "title": "Heart Failure With Preserved Ejection Fraction: From a Vascular Perspective", "publicationYear": 2024, "publicationDate": "2024-09", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "17", "issue": "9", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Guillaume Goudot, Marie Denise Gerhard-Herman", "authorCount": 2, "firstAuthorAffiliation": "Vascular Medicine Department, Université Paris Cité, Vascular Medicine Department, Georges Pompidou European Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France. Vascular Medicine Department, Université Paris Cité, Georges Pompidou European Hospital, Assistance Publique - Hôpitaux de Paris, France (G.G.).", "isReferencedByCount": 3, "referenceCount": 9, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.124.012187", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1253/circj.cj-18-1305", "doi": "10.1253/circj.cj-18-1305", "title": "Heart Failure Mid-Range Ejection Fraction ― Heart Failure With Multiple Personalities ―", "publicationYear": 2019, "publicationDate": "2019-01-25", "type": "journal-article", "publisher": "Japanese Circulation Society", "containerTitle": "Circulation Journal", "volume": "83", "issue": "2", "page": "274-276", "issn": "1346-9843, 1347-4820", "isbn": null, "authors": "Shin-ichi Momomura, Miyuki Ito", "authorCount": 2, "firstAuthorAffiliation": "Cardiovascular Medicine, Saitama Medical Center Jichi Medical University", "isReferencedByCount": 0, "referenceCount": 14, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1253/circj.cj-18-1305", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.112.000216", "doi": "10.1161/circheartfailure.112.000216", "title": "Effects of Exercise on Left Ventricular Systolic and Diastolic Properties in Patients With Heart Failure and a Preserved Ejection Fraction Versus Heart Failure and a Reduced Ejection Fraction", "publicationYear": 2013, "publicationDate": "2013-05", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "6", "issue": "3", "page": "508-516", "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Michael R. Zile, Barbro Kjellstrom, Tom Bennett, Yong Cho, Catalin F. Baicu, Mark F. Aaron, William T. Abraham, Robert C. Bourge, Fred J. Kueffer", "authorCount": 9, "firstAuthorAffiliation": "From the Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, SC (M.R.Z., C.F.B.); Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (B.K.); Medtronic, Inc, Minneapolis, MN (T.B., Y.C., F.J.K.); St Thomas Hospital, Nashville, TN (M.F.A.); Ohio State University, Columbus, OH (W.T.A.), and University of Alabama at Birmingham, Birmingham, AL (R.C.B.).", "isReferencedByCount": 58, "referenceCount": 31, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.112.000216", "pdfUrl": null, "abstract": "Background— The purpose of the current study was to define exercise-induced changes in indices of left ventricular (LV) systolic and diastolic properties in patients with chronic heart failure (HF), compare these changes in patients with HF and a reduced ejection fraction (EF) versus HF and a preserved EF, and compare the hemodynamic responses to activities of daily living with symptom-limited upright exercise. Methods and Results— Subjects with HF and a preserved EF (n=8) and subjects with HF and a reduced EF (n=5) underwent symptom-limited Naughton protocol treadmill exercise tests. Implantable hemodynamic monitor data and echocardiographic data were obtained before exercise and at peak exercise. Implantable hemodynamic monitor data were obtained during activities of daily living during a 24-hour time period. In patients with HF and a reduced EF, limited exercise time (639±164 seconds) was associated with a marked rise in right ventricular systolic, diastolic, and estimated pulmonary artery diastolic (ePAD) pressures and an increase in LV end diastolic volume (EDV). LV systolic properties, namely EF, end systolic elastance, stroke work, and preload recruitable stroke work, all decreased. The ePAD/EDV ratio increased; to a large extent, this was dependent on an increase in EDV. By contrast, in HF and a preserved EF, limited exercise time (411±128 seconds) and the marked rise in right ventricular systolic, diastolic, and ePAD pressures were associated with no change in LV EDV. LV systolic properties increased or were unchanged; ePAD/EDV ratio increased during exercise, but the increase was independent of a change in EDV. The ranges of right ventricular systolic, diastolic, and ePAD pressures during activities of daily living were higher than the ranges of these values during the exercise stress test. Conclusions— Although exercise limitations were similar between HF and a reduced EF and HF and a preserved EF, there were significant differences in exercise-induced changes in LV systolic and diastolic properties. These differences likely reflect the different pathophysiologies of these clinical syndromes of HF.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.113.000823", "doi": "10.1161/circheartfailure.113.000823", "title": "Pulmonary Hypertension in Heart Failure Preserved Ejection Fraction", "publicationYear": 2014, "publicationDate": "2014-03", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "7", "issue": "2", "page": "367-377", "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Marco Guazzi", "authorCount": 1, "firstAuthorAffiliation": "From the Heart Failure Unit and Cardiopulmonary Laboratory, Cardiology, IRCCS, Policlinico San Donato University Hospital, Milan, Italy.", "isReferencedByCount": 113, "referenceCount": 66, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.113.000823", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1016/j.hlc.2026.07.339", "doi": "10.1016/j.hlc.2026.07.339", "title": "Prescription Rates of Guideline-Directed Medical Therapy in Cardiology Patients Admitted With Heart Failure With Reduced Ejection Fraction (HFrEF) or Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)", "publicationYear": 2026, "publicationDate": "2026-08", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Heart, Lung and Circulation", "volume": "35", "issue": null, "page": "S258", "issn": "1443-9506", "isbn": null, "authors": "R. Lambert, J. Ang, A. Hijazi, R. Useelananthan, U. Premawardhana, K. Kadappu", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.hlc.2026.07.339", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.119.006213", "doi": "10.1161/circheartfailure.119.006213", "title": "Heart Rate and Heart Failure With Preserved Ejection Fraction", "publicationYear": 2019, "publicationDate": "2019-08", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "12", "issue": "8", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Markus Meyer, Martin M LeWinter", "authorCount": 2, "firstAuthorAffiliation": "Cardiology Unit, Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington.", "isReferencedByCount": 79, "referenceCount": 28, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.119.006213", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circ.150.suppl_1.4141805", "doi": "10.1161/circ.150.suppl_1.4141805", "title": "Abstract 4141805: High Frequency of Ejection Fraction Decline in Patients with Heart Failure with Improved Ejection Fraction", "publicationYear": 2024, "publicationDate": "2024-11-12", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "150", "issue": "Suppl_1", "page": null, "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "Anthony Pensa, Lucia Davis, Tingqing Wu, Veronica Zheng, Rebecca Harap, Jane Wilcox", "authorCount": 6, "firstAuthorAffiliation": "Northwestern University, Chicago, Illinois, United States", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circ.150.suppl_1.4141805", "pdfUrl": null, "abstract": "Background: Heart failure with improved ejection fraction (HFimpEF) is defined by prior HF with reduced EF (HFrEF) and evidence of systolic improvement and is associated with improved outcomes. Despite this, HFimpEF patients remain at risk of future adverse events, including EF decline. However, little is known about factors associated with EF trajectory in this population. Question: Are baseline clinical characteristics associated with future EF decline in HFimpEF? Goals: To describe the EF trajectory in HFimpEF and to identify if clinical characteristics are predictive of eventual EF decline. Methods: This was a retrospective observational study of 115 patients in our HFimpEF registry. Inclusion criteria were a history of HFimpEF (prior HFrEF [EF ≤40%] with subsequent EF improvement ≥10% and resulting EF &gt;40%) and at least one follow-up echocardiogram after improvement. The primary outcome was EF decline (EF drop ≥10% from peak improvement EF). Cox proportional hazard models were built using baseline factors at time of HFrEF diagnosis to identify predictors of EF decline. Results: The median time from initial HFrEF diagnosis to development of HFimpEF was 0.61 years (IQR 0.26-1.17). Most patients (77%) continued to have EF improvement after HFimpEF diagnosis, and the peak EF was 60% (IQR 54-65%). Over a mean follow-up of 4.7±3.2 years, 35 (30%) HFimpEF patients developed EF decline. Baseline characteristics were similar between those with sustained EF and EF decline ( Table 1 ), as was peak EF (60.0% vs 60.3%, p=0.571). Indexed end-systolic dimension (1.78 vs 1.93 cm/m 2 , p=0.014) was smaller at time of HFimpEF diagnosis in those with sustained EF. In multivariate analysis, current/former tobacco use was associated with EF decline (HR 2.60, 95% CI 1.02-6.63, p=0.045; Table 2 ). Conclusions: Many HFimpEF patients develop EF decline, highlighting the need for continual clinical follow up in this high-risk patient population.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1253/circrep.cr-20-0021", "doi": "10.1253/circrep.cr-20-0021", "title": "Heart Failure With Preserved Ejection Fraction vs. Reduced Ejection Fraction ― Mechanisms of Ventilatory Inefficiency During Exercise in Heart Failure ―", "publicationYear": 2020, "publicationDate": "2020-05-08", "type": "journal-article", "publisher": "Japanese Circulation Society", "containerTitle": "Circulation Reports", "volume": "2", "issue": "5", "page": "271-279", "issn": "2434-0790", "isbn": null, "authors": "Shingo Tsujinaga, Hiroyuki Iwano, Yasuyuki Chiba, Suguru Ishizaka, Miwa Sarashina, Michito Murayama, Masahiro Nakabachi, Hisao Nishino, Shinobu Yokoyama, Kazunori Okada, Sanae Kaga, Toshihisa Anzai", "authorCount": 12, "firstAuthorAffiliation": "Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University", "isReferencedByCount": 7, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1253/circrep.cr-20-0021", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circulationaha.108.819318", "doi": "10.1161/circulationaha.108.819318", "title": "Hypertension, Heart Failure, and Ejection Fraction", "publicationYear": 2008, "publicationDate": "2008-11-25", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "118", "issue": "22", "page": "2223-2223", "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "William C. Little", "authorCount": 1, "firstAuthorAffiliation": "From the Section of Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC.", "isReferencedByCount": 12, "referenceCount": 14, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circulationaha.108.819318", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/hhf.0000000000000075", "doi": "10.1161/hhf.0000000000000075", "title": "Correction to: “Polygenic Score for β-Blocker Survival Benefit in European Ancestry Patients With Reduced Ejection Fraction Heart Failure”", "publicationYear": 2022, "publicationDate": "2022-04", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "15", "issue": "4", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/hhf.0000000000000075", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.122.009867", "doi": "10.1161/circheartfailure.122.009867", "title": "Why We Should Care About Who Cares for Patients With Heart Failure With Preserved Ejection Fraction", "publicationYear": 2022, "publicationDate": "2022-08", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "15", "issue": "8", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Sanjiv J. Shah", "authorCount": 1, "firstAuthorAffiliation": "Division of Cardiology, Department of Medicine, and Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL.", "isReferencedByCount": 6, "referenceCount": 14, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.122.009867", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/cir.0000000000000464", "doi": "10.1161/cir.0000000000000464", "title": "Correction to: Heart Failure With Preserved Ejection Fraction: A Kidney Disorder?", "publicationYear": 2016, "publicationDate": "2016-10-04", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "134", "issue": "14", "page": null, "issn": "0009-7322, 1524-4539", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/cir.0000000000000464", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/res.133.suppl_1.p2086", "doi": "10.1161/res.133.suppl_1.p2086", "title": "Abstract P2086: Targeting Endothelial Dysfunction And Senescence An Heart Failure With Preserved Ejection Fraction - A Whole Transcriptome Analysis Of Heart Failure With Preserved Ejection Fraction-patients To Identify New Therapeutic Targets", "publicationYear": 2023, "publicationDate": "2023-08-04", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation Research", "volume": "133", "issue": "Suppl_1", "page": null, "issn": "0009-7330, 1524-4571", "isbn": null, "authors": "Leonie Wurmbrand, Katrin Kalies, Kai Knoepp, Jochen Dutzmann, Daniel SEDDING", "authorCount": 5, "firstAuthorAffiliation": "Univ Hosp Halle (Saale), Halle, Germany", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/res.133.suppl_1.p2086", "pdfUrl": null, "abstract": "Heart failure with preserved ejection fraction (HFpEF) remains a disease with a poor prognosis and increasing incidence in all Western countries mainly affecting the aging population. A deeper understanding of pathogenesis at the cellular level, particularly the central role of endothelial dysfunction in cellular senescence, is required for the development of new therapeutic approaches. Circulating endothelial cells as a marker for endothelial damage and dysfunction, have already been examined quantitatively in general HF patients, HFpEF patients and healthy subjects. Here, we aim to isolate circulating endothelial cells to target endothelial dysfunction and identify new therapeutic targets by whole transcriptome analysis.Methods included the isolation of circulating endothelial cells (CEC) from whole blood samples via a newly established FACS panel. HFpEF patients were included based on their HFA-PEFF score. Young and old subjects served as non-diseased controls and were matched as closely as possible for sex and age. CEC were further processed for a whole transcriptome analysis. In total, we collected samples from n=15 patients per group. Mean age was 82.3 for the HFpEF group, 64.5 for the non-diseased control ‘old’, and 25 years for the non- diseased control ‘young’, HFA-PEFF score was 5, 0, and 0 points (P&lt;0.05), and the proportion of female patients was 66%, 78%, and 77%, respectively. Including additional patient data, our collective was shown to be comparable to large HFpEF studies and clinical registries. CEC cells were sorted based on CD45-, CD11b- CD34+, CD31+ and CD146+ marker expression. The CEC of the aged group revealed upregulated expression of senescence markers p16, p21 and CD44. In gene set enrichment analysis, we see trends of differentiation of mainly proliferation- and transcription-associated gene sets in heart failure with preserved ejection fraction. In summary, we achieved to isolate CEC from whole blood of HFpEF-patients and matched controls. The whole transcriptome analyses may provide new clues for therapeutic strategies, which is now the subject of further in vitro and in vivo studies. Our goal is to develop new therapeutic targets after successful evaluation and modulation of the target genes.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.119.006833", "doi": "10.1161/circheartfailure.119.006833", "title": "Improvement in Left Ventricular Ejection Fraction in Outpatients With Heart Failure With Reduced Ejection Fraction", "publicationYear": 2020, "publicationDate": "2020-07", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "13", "issue": "7", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Adam D. DeVore, Anne S. Hellkamp, Laine Thomas, Nancy M. Albert, Javed Butler, J. Herbert Patterson, John A. Spertus, Fredonia B. Williams, Carol I. Duffy, Adrian F. Hernandez, Gregg C. Fonarow", "authorCount": 11, "firstAuthorAffiliation": "Duke Clinical Research Institute, Durham, NC (A.D.D., A.S.H., L.T., A.F.H.).", "isReferencedByCount": 43, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.119.006833", "pdfUrl": null, "abstract": "Background: Among patients with heart failure (HF) with reduced ejection fraction (EF), improvements in left ventricular EF (LVEF) are associated with better outcomes and remain an important treatment goal. Patient factors associated with LVEF improvement in routine clinical practice have not been clearly defined. Methods: CHAMP-HF (Change the Management of Patients with Heart Failure) is a prospective registry of outpatients with HF with reduced EF. Assessments of LVEF are recorded when performed for routine care. We analyzed patients with both baseline and ≥1 follow-up LVEF assessments to describe factors associated with LVEF improvement. Results: In CHAMP-HF, 2623 patients had a baseline and follow-up LVEF assessment. The median age was 67 (interquartile range, 58–75) years, 40% had an ischemic cardiomyopathy, and median HF duration was 2.8 years (0.7–6.8). Median LVEF was 30% (23–35), and median change on follow-up was 4% (−2 to −13); 19% of patients had a decrease in LVEF, 31% had no change, 49% had a ≥5% increase, and 34% had a ≥10% increase. In a multivariable model, the following factors were associated with ≥5% LVEF increase: shorter HF duration (odds ratio [OR], 1.21 [95% CI, 1.17–1.25]), no implantable cardioverter defibrillator (OR, 1.46 [95% CI, 1.34–1.55]), lower LVEF (OR, 1.15 [95% CI, 1.10–1.19]), nonischemic cardiomyopathy (OR, 1.24 [95% CI, 1.09–1.36]), and no coronary disease (OR, 1.20 [95% CI, 1.03–1.35]). Conclusions: In a large cohort of outpatients with chronic HF with reduced EF, improvements in LVEF were common. Common baseline cardiac characteristics identified a population that was more likely to respond over time. These data may inform clinical decision making and should be the basis for future research on myocardial recovery.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/hhf.0000000000000031", "doi": "10.1161/hhf.0000000000000031", "title": "Correction to: Prognostic Value of Albuminuria and Influence of Spironolactone in Heart Failure With Preserved Ejection Fraction: The TOPCAT Trial", "publicationYear": 2018, "publicationDate": "2018-12", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "11", "issue": "12", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/hhf.0000000000000031", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circulationaha.115.018954", "doi": "10.1161/circulationaha.115.018954", "title": "Conventional Wisdom in Heart Failure Treatment Challenged Again", "publicationYear": 2015, "publicationDate": "2015-11-03", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "132", "issue": "18", "page": "1687-1689", "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "Dalane W. Kitzman", "authorCount": 1, "firstAuthorAffiliation": "From Sections on Cardiovascular Medicine and Gerontology, Wake Forest School of Medicine, Winston-Salem, NC.", "isReferencedByCount": 2, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circulationaha.115.018954", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.125.013183", "doi": "10.1161/circheartfailure.125.013183", "title": "Atrioventricular Dyssynchrony and Dyspnea in Heart Failure With Preserved Ejection Fraction", "publicationYear": 2025, "publicationDate": "2025-07", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "18", "issue": "7", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Teodora Donisan, Sara Inglis, Samuel J. Asirvatham, Barry A. Borlaug", "authorCount": 4, "firstAuthorAffiliation": "Division of Cardiovascular Diseases, Department of Medicine (T.D., S.I., S.J.A., B.A.B.), Mayo Clinic, Rochester, MN.", "isReferencedByCount": 0, "referenceCount": 4, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.125.013183", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.109.924191", "doi": "10.1161/circheartfailure.109.924191", "title": "Letter by Prakash Regarding Article “Impaired Heart Rate Recovery and Chronotropic Incompetence in Patients With Heart Failure With Preserved Ejection Fraction”", "publicationYear": 2010, "publicationDate": "2010-03", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "3", "issue": "2", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "E.S. Prakash", "authorCount": 1, "firstAuthorAffiliation": "Department of Physiology, Faculty of Medicine, AIMST University, Bedong, Kedah, Malaysia", "isReferencedByCount": 0, "referenceCount": 5, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.109.924191", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.117.004179", "doi": "10.1161/circheartfailure.117.004179", "title": "Microvascular Paradigm in Heart Failure With Preserved Ejection Fraction", "publicationYear": 2017, "publicationDate": "2017-06", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "10", "issue": "6", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Mark T. Waddingham, Walter J. Paulus", "authorCount": 2, "firstAuthorAffiliation": "From the Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, The Netherlands.", "isReferencedByCount": 12, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.117.004179", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circulationaha.117.031622", "doi": "10.1161/circulationaha.117.031622", "title": "Sex and Race Differences in Lifetime Risk of Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction", "publicationYear": 2018, "publicationDate": "2018-04-24", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "137", "issue": "17", "page": "1814-1823", "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "Ambarish Pandey, Wally Omar, Colby Ayers, Michael LaMonte, Liviu Klein, Norrina B. Allen, Lewis H. Kuller, Philip Greenland, Charles B. Eaton, John S. Gottdiener, Donald M. Lloyd-Jones, Jarett D. Berry", "authorCount": 12, "firstAuthorAffiliation": "Division of Cardiology (A.P., W.O., C.A., J.D.B.)", "isReferencedByCount": 204, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circulationaha.117.031622", "pdfUrl": null, "abstract": "Background: Lifetime risk of heart failure has been estimated to range from 20% to 46% in diverse sex and race groups. However, lifetime risk estimates for the 2 HF phenotypes, HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF), are not known. Methods: Participant-level data from 2 large prospective cohort studies, the CHS (Cardiovascular Health Study) and MESA (Multiethnic Study of Atherosclerosis), were pooled, excluding individuals with prevalent HF at baseline. Remaining lifetime risk estimates for HFpEF (EF ≥45%) and HFrEF (EF &lt;45%) were determined at different index ages with the use of a modified Kaplan-Meier method with mortality and the other HF subtype as competing risks. Results: We included 12 417 participants &gt;45 years of age (22.2% blacks, 44.8% men) who were followed up for median duration of 11.6 years with 2178 overall incident HF events with 561 HFrEF events and 726 HFpEF events. At the index age of 45 years, the lifetime risk for any HF through 90 years of age was higher in men than women (27.4% versus 23.8%). Among HF subtypes, the lifetime risk for HFrEF was higher in men than women (10.6% versus 5.8%). In contrast, the lifetime risk for HFpEF was similar in men and women. In race-stratified analyses, lifetime risk for overall HF was higher in nonblacks than blacks (25.9% versus 22.4%). Among HF subtypes, the lifetime risk for HFpEF was higher in nonblacks than blacks (11.2% versus 7.7%), whereas that for HFrEF was similar across the 2 groups. Among participants with antecedent myocardial infarction before HF diagnosis, the remaining lifetime risks for HFpEF and HFrEF were up to 2.5-fold and 4-fold higher, respectively, compared with those without antecedent myocardial infarction. Conclusions: Lifetime risks for HFpEF and HFrEF vary by sex, race, and history of antecedent myocardial infarction. These insights into the distribution of HF risk and its subtypes could inform the development of targeted strategies to improve population-level HF prevention and control.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circ.146.suppl_1.13786", "doi": "10.1161/circ.146.suppl_1.13786", "title": "Abstract 13786: Effectiveness of Ambulatory Pulmonary Artery Pressure-Guided Therapy in Reducing Readmissions in Patients With Heart Failure With Reduced Ejection Fraction versus Heart Failure With Preserved Ejection Fraction", "publicationYear": 2022, "publicationDate": "2022-11-08", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation", "volume": "146", "issue": "Suppl_1", "page": null, "issn": "0009-7322, 1524-4539", "isbn": null, "authors": "Akshay Goel, Aaqib H Malik, Dhrubajyoti Bandyopadhyay, Rahul Gupta, Adrija Hajra, Alexandros Briasoulis, Wilbert S Aronow, Julio A Panza, Gregg Lanier", "authorCount": 9, "firstAuthorAffiliation": "Westchester Med Cntr, New York Med College, Valhalla, NY", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circ.146.suppl_1.13786", "pdfUrl": null, "abstract": "Introduction: The cardio-microelectromechanical system (CardioMEMS) is an implantable pulmonary artery pressure monitoring device that aims to avoid decompensated heart failure (HF) admissions through hemodynamic-guided care. The aim of our study was to compare the impact of CardioMEMS implantation on hospital readmissions between HFrEF and HFpEF patients. Methods: Data from the National Readmission Database 2015 to 2019 were analyzed. International Classification of Diseases codes were used to identify patients hospitalized for HF and those with CardioMEMS implantation. The outcome of interest was the 30-day readmission rate. Multivariate logistic regression analysis was done to account for possible confounders. Results: We identified 3,801,661 admissions with a primary diagnosis of HF. Of these, 2,279,203 (59.95%) patients carried a diagnosis of HFrEF, while 1,522,458 (40.05%) had HFpEF. Patient characteristics are shown in the table. CardioMEMS was implanted in 1100 patients with HFrEF, and 297 patients with HFpEF. Among patients with HFrEF, those who received CardioMEMS implantation during the index admission had a significantly lower 30-day readmission rate compared to those who did not (16.4% vs 21.0%, adjusted odds ratio [OR] 0.74, 95% confidence interval [CI] 0.63-0.87, p &lt;0.01) (Figure). However, among HFpEF patients, there was no significant reduction in 30-day readmissions after CardioMEMS implantation (19.8% vs 20.7%, adjusted OR 0.95, 95% CI 0.72-1.27, p = 0.37) (Figure). CardioMEMS implantation was not associated with a higher rate of complications such as major bleeding, acute kidney injury, or stroke, in both HFrEF and HFpEF groups. Conclusions: Our findings suggest that ambulatory pulmonary artery pressure-guided therapy may be more effective in reducing HF readmissions in patients with HFrEF than in those with HFpEF. This may have significant clinical implication in appropriate patient selection for CardioMEMS implantation.", "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1161/circheartfailure.116.003272", "doi": "10.1161/circheartfailure.116.003272", "title": "Zooming in on the Microvasculature in Heart Failure With Preserved Ejection Fraction", "publicationYear": 2016, "publicationDate": "2016-07", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Circulation: Heart Failure", "volume": "9", "issue": "7", "page": null, "issn": "1941-3289, 1941-3297", "isbn": null, "authors": "Selma F. Mohammed, David T. Majure, Margaret M. Redfield", "authorCount": 3, "firstAuthorAffiliation": "From the MedStar Cardiovascular Research Network, Washington, DC (S.F.M., D.T.M.); and Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN (M.M.R.).", "isReferencedByCount": 26, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1161/circheartfailure.116.003272", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.1016/j.hlc.2023.06.054", "doi": "10.1016/j.hlc.2023.06.054", "title": "Changes in Left Ventricular Ejection Fraction (LVEF) Predict Mortality in Heart Failure Patients With Reduced Ejection Fraction", "publicationYear": 2023, "publicationDate": "2023-07", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Heart, Lung and Circulation", "volume": "32", "issue": null, "page": "S146", "issn": "1443-9506", "isbn": null, "authors": "L. Kearney, A. Williamson, E. Chowdhury, M. Duong, J. McGillion, N. Schwarz, D. Eccleston", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.hlc.2023.06.054", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "nj5YG48JjwL87PJPG", "_dataset_id": "4bGdorXWrGItmYWNp"}
{"paperId": "10.5772/intechopen.78235", "doi": "10.5772/intechopen.78235", "title": "Carbon Dioxide Utilization and Sequestration in Kerogen Nanopores", "publicationYear": 2018, "publicationDate": "2018-09-12", "type": "book-chapter", "publisher": "InTech", "containerTitle": "Carbon Capture, Utilization and Sequestration", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9781789237641, 9781789237658", "authors": "Cudjoe Sherifa, Barati Reza", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/3.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5772/intechopen.78235", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.5772/intechopen.79414", "doi": "10.5772/intechopen.79414", "title": "Interfacial Tension and Contact Angle Data Relevant to Carbon Sequestration", "publicationYear": 2018, "publicationDate": "2018-09-12", "type": "book-chapter", "publisher": "InTech", "containerTitle": "Carbon Capture, Utilization and Sequestration", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9781789237641, 9781789237658", "authors": "Prem Bikkina, Imran Shaik", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 81, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/3.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5772/intechopen.79414", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.5772/intechopen.78394", "doi": "10.5772/intechopen.78394", "title": "An Innovative Approach in Post Combustion Carbon Capture and Sequestration towards Reduction of Energy Penalty in Regeneration of Solvent", "publicationYear": 2018, "publicationDate": "2018-09-12", "type": "book-chapter", "publisher": "InTech", "containerTitle": "Carbon Capture, Utilization and Sequestration", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9781789237641, 9781789237658", "authors": "Vinod Krishna Sethi, Partha S. Dutta", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/3.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5772/intechopen.78394", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1016/j.ccst.2024.100257", "doi": "10.1016/j.ccst.2024.100257", "title": "Biomimetic mineralization for carbon capture and sequestration", "publicationYear": 2024, "publicationDate": "2024-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Carbon Capture Science &amp; Technology", "volume": "13", "issue": null, "page": "100257", "issn": "2772-6568", "isbn": null, "authors": "Yifei Ma, Shouliang Yi, Meng Wang", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 17, "referenceCount": 202, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.ccst.2024.100257", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.5772/intechopen.79347", "doi": "10.5772/intechopen.79347", "title": "Carbon Sequestration in Soils: The Opportunities and Challenges", "publicationYear": 2018, "publicationDate": "2018-09-12", "type": "book-chapter", "publisher": "InTech", "containerTitle": "Carbon Capture, Utilization and Sequestration", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9781789237641, 9781789237658", "authors": "Ahmed Chinade Abdullahi, Chamhuri Siwar, Mohamad Isma’il Shaharudin, Isahak Anizan", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 16, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/3.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5772/intechopen.79347", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.58445/rars.770", "doi": "10.58445/rars.770", "title": "Assessment of carbon capture techniques and their carbon sequestration potential, technical characteristics, and cost.", "publicationYear": 2023, "publicationDate": "2023-12-03", "type": "posted-content", "publisher": "Polygence", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Connor Yu", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.58445/rars.770", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.5772/intechopen.84428", "doi": "10.5772/intechopen.84428", "title": "Carbon Capture and Storage (CCS): Geological Sequestration of CO<sub>2</sub>", "publicationYear": 2020, "publicationDate": "2020-07-22", "type": "book-chapter", "publisher": "IntechOpen", "containerTitle": "CO2 Sequestration", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9781839629921, 9781839629938", "authors": "Nediljka Gaurina-Međimurec, Karolina Novak Mavar", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 20, "referenceCount": 53, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/3.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5772/intechopen.84428", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
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{"paperId": "10.1039/c9nr10552b", "doi": "10.1039/c9nr10552b", "title": "Transformation of carbon dioxide into carbon nanotubes for enhanced ion transport and energy storage", "publicationYear": 2020, "publicationDate": "2020", "type": "journal-article", "publisher": "Royal Society of Chemistry (RSC)", "containerTitle": "Nanoscale", "volume": "12", "issue": "14", "page": "7822-7833", "issn": "2040-3364, 2040-3372", "isbn": null, "authors": "Gi Mihn Kim, Won-Gwang Lim, Dohyung Kang, Jae Hyun Park, Hyunjoo Lee, Jinwoo Lee, Jae W. Lee", "authorCount": 7, "firstAuthorAffiliation": "Department of Chemical and Biomolecular Engineering", "isReferencedByCount": 59, "referenceCount": 61, "isOpenAccess": true, "licenseUrl": "http://rsc.li/journals-terms-of-use", "funderNames": "Korea Carbon Capture and Sequestration R and D Center, Korea Carbon Capture and Sequestration R and D Center", "funderIds": "10.13039/501100010239, 10.13039/501100010239", "url": "https://doi.org/10.1039/c9nr10552b", "pdfUrl": null, "abstract": "CO 2 -derived-CNTs (CCNTs) prepared at 500–700 °C (1 atm) show excellent supercapacitance due to B/O doping and fast ion transport through mesoporous CCNT fibers.", "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
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{"paperId": "10.3390/thermo5010008", "doi": "10.3390/thermo5010008", "title": "Power and Energy Requirements for Carbon Capture and Sequestration", "publicationYear": 2025, "publicationDate": "2025-03-02", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Thermo", "volume": "5", "issue": "1", "page": "8", "issn": "2673-7264", "isbn": null, "authors": "Efstathios E. Michaelides", "authorCount": 1, "firstAuthorAffiliation": "Department of Engineering, Texas Christian University, Fort Worth, TX 76129, USA", "isReferencedByCount": 10, "referenceCount": 60, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/thermo5010008", "pdfUrl": null, "abstract": "Carbon capture and sequestration have been recently presented as a viable option to reduce atmospheric carbon dioxide emissions and mitigate global climate change. The concept entails the capture, compression, transportation, and injection of the gas into a medium suitable for storage. This paper examines the thermodynamic and transport properties of carbon dioxide that are pertinent to its sequestration and storage, describes the various methods that have been recommended for its separation from the mixture of the flue gases, and determines the mechanical power and heat rate required for the capture of the gas. The power required for the compression and transportation of the gas by a pipeline is also determined, as well as the effect of the ambient temperature on the transportation power. Calculations for the total power required are performed for two cases, one a cement production unit and the second a coal power plant. The mechanical power needed for the sequestration of CO2 is substantial in both cases, with the cement unit needing less power because of the availability of high-temperature waste heat. In both cases, the equivalent mechanical work needed for the sequestration and storage of this gas is on the order of 1 MJ per kg CO2 sequestered.", "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1017/9781009008877.012", "doi": "10.1017/9781009008877.012", "title": "Direct Air Carbon Capture and Sequestration", "publicationYear": 2022, "publicationDate": "2022-02-28", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Pandora's Toolbox", "volume": null, "issue": null, "page": "187-198", "issn": null, "isbn": "9781009008877, 9781316518434, 9781009009225", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/9781009008877.012", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1016/j.ccst.2026.100570", "doi": "10.1016/j.ccst.2026.100570", "title": "Investigating carbon sequestration in cementitious mortars with low-carbon binders and carbonated water", "publicationYear": 2026, "publicationDate": "2026-03", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Carbon Capture Science &amp; Technology", "volume": "18", "issue": null, "page": "100570", "issn": "2772-6568", "isbn": null, "authors": "Aswathy Rajendran, Sripriya Rengaraju, Abir Al-Tabbaa", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 99, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Engineering and Physical Sciences Research Council", "funderIds": "10.13039/501100000266", "url": "https://doi.org/10.1016/j.ccst.2026.100570", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.5772/intechopen.79082", "doi": "10.5772/intechopen.79082", "title": "CO2 Miscible Flooding for Enhanced Oil Recovery", "publicationYear": 2018, "publicationDate": "2018-09-12", "type": "book-chapter", "publisher": "InTech", "containerTitle": "Carbon Capture, Utilization and Sequestration", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9781789237641, 9781789237658", "authors": "Abdelaziz Nasr El-hoshoudy, Saad Desouky", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 22, "referenceCount": 80, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/3.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5772/intechopen.79082", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1016/j.fuel.2017.11.106", "doi": "10.1016/j.fuel.2017.11.106", "title": "Chemical looping partial oxidation of methane with CO2 utilization on the ceria-enhanced mesoporous Fe2O3 oxygen carrier", "publicationYear": 2018, "publicationDate": "2018-03", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Fuel", "volume": "215", "issue": null, "page": "787-798", "issn": "0016-2361", "isbn": null, "authors": "Dohyung Kang, Minbeom Lee, Hyun Suk Lim, Jae W. Lee", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 87, "referenceCount": 56, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Korea Carbon Capture and Sequestration R and D Center, Korea Carbon Capture and Sequestration R and D Center", "funderIds": "10.13039/501100010239, 10.13039/501100010239", "url": "https://doi.org/10.1016/j.fuel.2017.11.106", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.5772/intechopen.105949", "doi": "10.5772/intechopen.105949", "title": "Carbon Capture, Use and Storage (CCUS) as Enhanced Oil Recovery (EOR): Llanos Orientales Basin (Colombia)", "publicationYear": 2022, "publicationDate": "2022-09-28", "type": "book-chapter", "publisher": "IntechOpen", "containerTitle": "Carbon Sequestration", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9781803556871, 9781803556888", "authors": "Jorge Eliecer Mariño Martínez, Luisa Epimenia Moreno Reyes", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 13, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/3.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5772/intechopen.105949", "pdfUrl": null, "abstract": "At present, it is essential to take actions to minimize CO2 emissions into the atmosphere, and one way to use and exploit it is through the use of carbon dioxide for industry processes, such as enhanced oil recovery. By carrying out carbon capture, geological storage and improving oil recovery by applying the selection criteria to determine suitability for CO2 sequestration in the Llanos Orientales Basin as a tool to improve hydrocarbon production. It would be a first step in the sustainable development of the extractive oil industry in Colombia, which is one of the participants in greenhouse gas releases. The above can be achieved through the application of CO2–EOR processes, which are mainly miscible or immiscible methods. Finally, the importance of identifying existing CO2 sources is highlighted, in order to carry out the application of a CO2–EOR project.", "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.5772/intechopen.78386", "doi": "10.5772/intechopen.78386", "title": "Geophysical Monitoring of CO2 Injection at Citronelle Field, Alabama", "publicationYear": 2018, "publicationDate": "2018-09-12", "type": "book-chapter", "publisher": "InTech", "containerTitle": "Carbon Capture, Utilization and Sequestration", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9781789237641, 9781789237658", "authors": "Shen-En Chen, Yangguang Liu", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/3.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5772/intechopen.78386", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1007/978-981-16-0029-6_2", "doi": "10.1007/978-981-16-0029-6_2", "title": "Carbon Capture and Sequestration: Implications and Opportunities for India", "publicationYear": 2021, "publicationDate": "2021", "type": "book-chapter", "publisher": "Springer Singapore", "containerTitle": "Green Energy and Technology", "volume": null, "issue": null, "page": "19-25", "issn": "1865-3529, 1865-3537", "isbn": "9789811600289, 9789811600296", "authors": "Anjan Ray", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 8, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-981-16-0029-6_2", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1002/9781119510079.ch16", "doi": "10.1002/9781119510079.ch16", "title": "Potential Evaluation Method of Carbon Dioxide Flooding and Sequestration", "publicationYear": 2019, "publicationDate": "2019-05-20", "type": "other", "publisher": "Wiley", "containerTitle": "The Three Sisters", "volume": null, "issue": null, "page": "311-331", "issn": null, "isbn": "9781119510062, 9781119510079", "authors": "Yongle Hu, Mingqiang Hao, Chao Wang, Xinwei Liao, Lina Song", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781119510079.ch16", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F9781119510079.ch16", "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1016/j.ccst.2025.100511", "doi": "10.1016/j.ccst.2025.100511", "title": "Accelerating CO2 sequestration in cementitious materials using carbonic anhydrase: Experimental insights into performance and mechanisms", "publicationYear": 2025, "publicationDate": "2025-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Carbon Capture Science &amp; Technology", "volume": "17", "issue": null, "page": "100511", "issn": "2772-6568", "isbn": null, "authors": "Xiulin Chen, Zhidong Zhang, Ueli Angst", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 105, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "ETH Zurich", "funderIds": "10.13039/501100003006", "url": "https://doi.org/10.1016/j.ccst.2025.100511", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.3390/en12091603", "doi": "10.3390/en12091603", "title": "Optimization of the Energy Consumption of a Carbon Capture and Sequestration Related Carbon Dioxide Compression Processes", "publicationYear": 2019, "publicationDate": "2019-04-26", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Energies", "volume": "12", "issue": "9", "page": "1603", "issn": "1996-1073", "isbn": null, "authors": "Steven Jackson, Eivind Brodal", "authorCount": 2, "firstAuthorAffiliation": "Instituttet for ingeniørvitenskap og sikkerhet IVT, UiT Norges Arktiske Universitet, 9019 Tromsø, Norway", "isReferencedByCount": 46, "referenceCount": 22, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/en12091603", "pdfUrl": null, "abstract": "It is likely that the future availability of energy from fossil fuels, such as natural gas, will be influenced by how efficiently the associated CO2 emissions can be mitigated using carbon capture and sequestration (CCS). In turn, understanding how CCS affects the efficient recovery of energy from fossil fuel reserves in different parts of the world requires data on how the performance of each part of a particular CCS scheme is affected by both technology specific parameters and location specific parameters, such as ambient temperature. This paper presents a study into how the energy consumption of an important element of all CCS schemes, the CO2 compression process, varies with compressor design, CO2 pipeline pressure, and cooling temperature. Post-combustion, pre-combustion, and oxyfuel capture scenarios are each considered. A range of optimization algorithms are used to ensure a consistent approach to optimization. The results show that energy consumption is minimized by compressor designs with multiple impellers per stage and carefully optimized stage pressure ratios. The results also form a performance map illustrating the energy consumption for CO2 compression processes that can be used in further study work and, in particular, CCS system models developed to study performance variation with ambient temperature.", "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1515/ci-2024-0219", "doi": "10.1515/ci-2024-0219", "title": "Advanced Technologies for Carbon Sequestration and Capture", "publicationYear": 2024, "publicationDate": "2024-04-01", "type": "journal-article", "publisher": "Walter de Gruyter GmbH", "containerTitle": "Chemistry International", "volume": "46", "issue": "2", "page": "33-34", "issn": "1365-2192, 0193-6484", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1515/ci-2024-0219", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1016/b978-0-12-819455-3.00007-8", "doi": "10.1016/b978-0-12-819455-3.00007-8", "title": "Membrane-based technology for carbon dioxide capture and sequestration", "publicationYear": 2020, "publicationDate": "2020", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "Membrane-Based Technologies for Environmental Pollution Control", "volume": null, "issue": null, "page": "359-368", "issn": null, "isbn": "9780128194553", "authors": "Parimal Pal", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 5, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-12-819455-3.00007-8", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1002/9781119510079.fmatter", "doi": "10.1002/9781119510079.fmatter", "title": "Front Matter", "publicationYear": 2019, "publicationDate": "2019-05-20", "type": "other", "publisher": "Wiley", "containerTitle": "The Three Sisters", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9781119510062, 9781119510079", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781119510079.fmatter", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F9781119510079.fmatter", "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1016/b978-0-08-101036-5.00005-7", "doi": "10.1016/b978-0-08-101036-5.00005-7", "title": "Biogenic Carbon—Capture and Sequestration", "publicationYear": 2018, "publicationDate": "2018", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "Greenhouse Gases Balances of Bioenergy Systems", "volume": null, "issue": null, "page": "55-76", "issn": null, "isbn": "9780081010365", "authors": "Zoe M. Harris, Suzanne Milner, Gail Taylor", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 16, "referenceCount": 96, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-08-101036-5.00005-7", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1002/9781119363804.ch4", "doi": "10.1002/9781119363804.ch4", "title": "Feasibility of Ex‐Situ Dissolution for Carbon Dioxide Sequestration", "publicationYear": 2018, "publicationDate": "2018-04-16", "type": "other", "publisher": "Wiley", "containerTitle": "Cutting‐Edge Technology for Carbon Capture, Utilization, and Storage", "volume": null, "issue": null, "page": "47-58", "issn": null, "isbn": "9781119363484, 9781119363804", "authors": "Yuri Leonenko", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781119363804.ch4", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F9781119363804.ch4", "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1016/b978-0-443-21927-6.00013-1", "doi": "10.1016/b978-0-443-21927-6.00013-1", "title": "Carbon capture and sequestration: a critical view of its future", "publicationYear": 2025, "publicationDate": "2025", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "Energy and Climate Change", "volume": null, "issue": null, "page": "505-524", "issn": null, "isbn": "9780443219276", "authors": "Patrick Moriarty, Damon Honnery", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 69, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-443-21927-6.00013-1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1016/j.ccst.2024.100306", "doi": "10.1016/j.ccst.2024.100306", "title": "Carbon capture and sequestration with in-situ CO2 and steam integrated 3D concrete printing", "publicationYear": 2024, "publicationDate": "2024-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Carbon Capture Science &amp; Technology", "volume": "13", "issue": null, "page": "100306", "issn": "2772-6568", "isbn": null, "authors": "Sean Gip Lim, Yi Wei Daniel Tay, Suvash Chandra Paul, Junghyun Lee, Issam T. Amr, Bandar A. Fadhel, Aqil Jamal, Ahmad O. Al-Khowaiter, Ming Jen Tan", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 78, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.ccst.2024.100306", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1016/j.egypro.2014.07.275", "doi": "10.1016/j.egypro.2014.07.275", "title": "Carbon Dioxide Capture and Sequestration by Adsorption on Activated Carbon", "publicationYear": 2014, "publicationDate": "2014", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Energy Procedia", "volume": "54", "issue": null, "page": "320-329", "issn": "1876-6102", "isbn": null, "authors": "Reema Saxena, Vinod Kumar Singh, E. Anil Kumar", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 52, "referenceCount": 17, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.egypro.2014.07.275", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1016/j.egypro.2011.02.108", "doi": "10.1016/j.egypro.2011.02.108", "title": "Coupling carbon dioxide sequestration with geothermal energy capture in naturally permeable, porous geologic formations: Implications for CO2 sequestration", "publicationYear": 2011, "publicationDate": "2011", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Energy Procedia", "volume": "4", "issue": null, "page": "2206-2213", "issn": "1876-6102", "isbn": null, "authors": "Jimmy B. Randolph, Martin O. Saar", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 175, "referenceCount": 28, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.egypro.2011.02.108", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1038/s41467-022-28807-6", "doi": "10.1038/s41467-022-28807-6", "title": "Sex-linked deubiquitinase establishes uniparental transmission of chloroplast DNA", "publicationYear": 2022, "publicationDate": "2022-03-03", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Communications", "volume": "13", "issue": "1", "page": null, "issn": "2041-1723", "isbn": null, "authors": "Sunjoo Joo, Thamali Kariyawasam, Minjae Kim, EonSeon Jin, Ursula Goodenough, Jae-Hyeok Lee", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 18, "referenceCount": 55, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "Korea Polar Research Institute, Korea Carbon Capture and Sequestration R and D Center, Korea Carbon Capture and Sequestration R and D Center, National Science Foundation, UBC | Faculty of Graduate Studies, University of British Columbia, Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada, Korea Carbon Capture and Sequestration R and D Center", "funderIds": "10.13039/501100004230, 10.13039/501100010239, 10.13039/501100010239, 10.13039/100000001, 10.13039/501100000187, 10.13039/501100000038, 10.13039/501100010239", "url": "https://doi.org/10.1038/s41467-022-28807-6", "pdfUrl": "https://www.nature.com/articles/s41467-022-28807-6.pdf", "abstract": "AbstractMost sexual organisms inherit organelles from one parent, commonly by excluding organelles from the smaller gametes. However, post-mating elimination of organelles derived from one gamete ensures uniparental inheritance, where the underlying mechanisms to distinguish organelles by their origin remain obscure. Mating in Chlamydomonas reinhardtii combines isomorphic plus and minus gametes, but chloroplast DNA from minus gametes is selectively degraded in zygotes. Here, we identify OTU2p (otubain protein 2), encoded in the plus mating-type locus MT+, as the protector of plus chloroplast. Otu2p is an otubain-like deubiquitinase, which prevents proteasome-mediated degradation of the preprotein translocase of the outer chloroplast membrane (TOC) during gametogenesis. Using OTU2p-knockouts and proteasome inhibitor treatment, we successfully redirect selective DNA degradation in chloroplasts with reduced TOC levels regardless of mating type, demonstrating that plus-specific Otu2p establishes uniparental chloroplast DNA inheritance. Our work documents that a sex-linked organelle quality control mechanism drives the uniparental organelle inheritance without dimorphic gametes.", "subject": null, "language": "en", "_run_id": "G6qprqZbD7XMLoddZ", "_dataset_id": "ATUypp8JCOYgQSsPO"}
{"paperId": "10.1201/9781420065756-8", "doi": "10.1201/9781420065756-8", "title": "Effects of climate -induced coral bleaching on coral -reef fishes — ecological and economic consequences", "publicationYear": 2008, "publicationDate": "2008-06-05", "type": "book-chapter", "publisher": "CRC Press", "containerTitle": "Oceanography and Marine Biology", "volume": null, "issue": null, "page": "257-302", "issn": null, "isbn": "9780429137259", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 1, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1201/9781420065756-8", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-007-0900-0", "doi": "10.1007/s00227-007-0900-0", "title": "Coral bleaching, bleaching-induced mortality, and the adaptive significance of the bleaching response", "publicationYear": 2008, "publicationDate": "2008-04", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "154", "issue": "1", "page": "65-80", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Ross J. Jones", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 90, "referenceCount": 78, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-007-0900-0", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-007-0900-0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-002-0982-7", "doi": "10.1007/s00227-002-0982-7", "title": "Alternate coral–bryozoan competitive superiority during coral bleaching", "publicationYear": 2003, "publicationDate": "2003-05", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "142", "issue": "5", "page": "989-996", "issn": "0025-3162", "isbn": null, "authors": "M. Fine, Y. Loya", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 24, "referenceCount": 66, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-002-0982-7", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-002-0982-7.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1016/s0025-326x(18)30514-9", "doi": "10.1016/s0025-326x(18)30514-9", "title": "Coral Bleaching and Climate Change", "publicationYear": 1999, "publicationDate": "1999-07", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Marine Pollution Bulletin", "volume": "38", "issue": "7", "page": "521", "issn": "0025-326X", "isbn": null, "authors": "Dan Harries", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0025-326x(18)30514-9", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/bf00349482", "doi": "10.1007/bf00349482", "title": "Evidence that reef-wide patterns of coral bleaching may be the result of the distribution of bleaching-susceptible clones", "publicationYear": 1994, "publicationDate": "1994-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "121", "issue": "1", "page": "137-142", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "P. J. Edmunds", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 84, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/bf00349482", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/BF00349482.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1071/mf99078", "doi": "10.1071/mf99078", "title": "Climate change, coral bleaching and the future of the world's coral reefs", "publicationYear": 1999, "publicationDate": "1999-11-23", "type": "journal-article", "publisher": "CSIRO Publishing", "containerTitle": "Marine and Freshwater Research", "volume": "50", "issue": "8", "page": "839-866", "issn": "1323-1650, 1448-6059", "isbn": null, "authors": "Ove Hoegh-Guldberg", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2186, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.1071/journalslicense", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1071/mf99078", "pdfUrl": "https://connectsci.au/mf/article-pdf/50/8/839/365383/mf99078.pdf", "abstract": "Sea temperatures in many tropical regions have increased by almost 1°C over the past 100 years, and are currently increasing at ~1–2°C per century. Coral bleaching occurs when the thermal tolerance of corals and their photosynthetic symbionts (zooxanthellae) is exceeded. Mass coral bleaching has occurred in association with episodes of elevated sea temperatures over the past 20 years and involves the loss of the zooxanthellae following chronic photoinhibition. Mass bleaching has resulted in significant losses of live coral in many parts of the world. This paper considers the biochemical, physiological and ecological perspectives of coral bleaching. It also uses the outputs of four runs from three models of global climate change which simulate changes in sea temperature and hence how the frequency and intensity of bleaching events will change over the next 100 years. The results suggest that the thermal tolerances of reef-building corals are likely to be exceeded every year within the next few decades. Events as severe as the 1998 event, the worst on record, are likely to become commonplace within 20 years. Most information suggests that the capacity for acclimation by corals has already been exceeded, and that adaptation will be too slow to avert a decline in the quality of the world’s reefs. The rapidity of the changes that are predicted indicates a major problem for tropical marine ecosystems and suggests that unrestrained warming cannot occur without the loss and degradation of coral reefs on a global scale.", "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-008-0972-5", "doi": "10.1007/s00227-008-0972-5", "title": "Symbiont specificity and bleaching susceptibility among soft corals in the 1998 Great Barrier Reef mass coral bleaching event", "publicationYear": 2008, "publicationDate": "2008-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "154", "issue": "5", "page": "795-804", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Tamar L. Goulet, Todd C. LaJeunesse, Katharina E. Fabricius", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 56, "referenceCount": 74, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-008-0972-5", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-008-0972-5.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-019-3515-3", "doi": "10.1007/s00227-019-3515-3", "title": "Two time losers: selective feeding by crown-of-thorns starfish on corals most affected by successive coral-bleaching episodes on western Australian coral reefs", "publicationYear": 2019, "publicationDate": "2019-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "166", "issue": "6", "page": null, "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "John K. Keesing, Damian P. Thomson, Michael D. E. Haywood, Russell C. Babcock", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 43, "referenceCount": 74, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-019-3515-3", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-019-3515-3.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1201/9781420065756.ch6", "doi": "10.1201/9781420065756.ch6", "title": "Effects Of Climate-Induced Coral Bleaching On Coral-Reef Fishes — Ecological And Economic Consequences", "publicationYear": 2008, "publicationDate": "2008-06-05", "type": "book-chapter", "publisher": "CRC Press", "containerTitle": "Oceanography and Marine Biology - An Annual Review", "volume": null, "issue": null, "page": "251-296", "issn": "2154-9125", "isbn": "9781420065749, 9781420065756", "authors": "Morgan Pratchett, Philip Munday, Shaun Wilson, Nicholas Graham, Joshua Cinner, David Bellwood, Geoffrey Jones, Nicholas Polunin, Tim Mcclanahan", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 330, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1201/9781420065756.ch6", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1016/s0065-2881(03)46004-5", "doi": "10.1016/s0065-2881(03)46004-5", "title": "Coral bleaching — capacity for acclimatization and adaptation", "publicationYear": 2003, "publicationDate": "2003", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "Advances in Marine Biology", "volume": null, "issue": null, "page": "183-223", "issn": "0065-2881", "isbn": "9780120261468", "authors": "S.L. Coles, Barbara E. Brown", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 307, "referenceCount": 198, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0065-2881(03)46004-5", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-018-3354-7", "doi": "10.1007/s00227-018-3354-7", "title": "Resilience in carbonate production despite three coral bleaching events in 5 years on an inshore patch reef in the Florida Keys", "publicationYear": 2018, "publicationDate": "2018-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "165", "issue": "6", "page": null, "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Derek P. Manzello, Ian C. Enochs, Graham Kolodziej, Renée Carlton, Lauren Valentino", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 34, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "NOAA Coral Reef Conservation Program and Ocean Acidification Program", "funderIds": null, "url": "https://doi.org/10.1007/s00227-018-3354-7", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-018-3354-7.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-002-0842-5", "doi": "10.1007/s00227-002-0842-5", "title": "The 1998 bleaching event and its aftermath on a coral reef in Belize", "publicationYear": 2002, "publicationDate": "2002-09-01", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "141", "issue": "3", "page": "435-447", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Aronson R., Precht W., Toscano M., Koltes K.", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 176, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-002-0842-5", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-002-0842-5.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/978-3-031-73584-4_19", "doi": "10.1007/978-3-031-73584-4_19", "title": "Marine Water Acidification and Coral Bleaching", "publicationYear": 2024, "publicationDate": "2024", "type": "book-chapter", "publisher": "Springer Nature Switzerland", "containerTitle": "Arctic Marine Ecotoxicology", "volume": null, "issue": null, "page": "403-420", "issn": null, "isbn": "9783031735837, 9783031735844", "authors": "Saidat Omowunmi Adeniran-Obey, Patrick Omoregie Isibor, Tunde Ohiokhioya Imoobe", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 54, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-3-031-73584-4_19", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-021-04013-8", "doi": "10.1007/s00227-021-04013-8", "title": "Recovery trajectories of oceanic reef ecosystems following multiple mass coral bleaching events", "publicationYear": 2022, "publicationDate": "2022-02", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "169", "issue": "2", "page": null, "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Fanny Vessaz, Charles J. Marsh, Jude Bijoux, Gilberte Gendron, Christophe Mason-Parker", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 62, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-021-04013-8", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s00227-021-04013-8.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-006-0318-0", "doi": "10.1007/s00227-006-0318-0", "title": "Coefficient of variation of sea surface temperature (SST) as an indicator of coral bleaching", "publicationYear": 2006, "publicationDate": "2006-09", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "149", "issue": "6", "page": "1337-1344", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Paul W. Sammarco, Amos Winter, J. Cody Stewart", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 25, "referenceCount": 66, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-006-0318-0", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-006-0318-0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-007-0786-x", "doi": "10.1007/s00227-007-0786-x", "title": "Ecological versatility and the decline of coral feeding fishes following climate driven coral mortality", "publicationYear": 2007, "publicationDate": "2007-11-14", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "153", "issue": "2", "page": "119-127", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Nicholas A. J. Graham", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 68, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-007-0786-x", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-007-0786-x.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-024-04495-2", "doi": "10.1007/s00227-024-04495-2", "title": "Back-to-back bleaching events in Peninsular Malaysia (2019–2020) selectively affect hard coral taxa across- and within-reef scales", "publicationYear": 2024, "publicationDate": "2024-09", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "171", "issue": "9", "page": null, "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Sebastian Szereday, Christian R. Voolstra, Affendi Y. Amri", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 20, "referenceCount": 102, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "Universität Konstanz", "funderIds": "10.13039/501100010583", "url": "https://doi.org/10.1007/s00227-024-04495-2", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s00227-024-04495-2.pdf", "abstract": "AbstractThe impacts of (repeat) bleaching events and the differential heat stress susceptibility of hard coral taxa are largely unknown in Malaysia, although it is part of the greater coral triangle. Here we determined bleaching trajectories of 46 hard coral taxa across- and within-reef scales based on data recorded during the first reported back-to-back coral bleaching occurrences in Malaysia between May 2019 and September 2020. Although the severity of coral bleaching in both years did not correspond to the rather small magnitude of heat stress observed, i.e., Degree Heating Weeks (DHW) of 1.05 °C-weeks and 0 °C-weeks in 2019 and 2020 respectively, we observed high levels of bleaching (55.21% and 26.63% of all surveyed colonies in 2019 and 2020, respectively). Notably, the bleaching response for both consecutive years was highly taxon-specific and significantly varied across- and within-reef scales. Mortality rates overall were low following the 2019 event, likely due to a rapid decrease in heat stress. Five of the 46 surveyed hard coral taxa exhibited more severe bleaching in 2020, despite a lower heat stress load. Interestingly, we observed low bleaching of ascribed susceptible taxa such as Acropora and Montipora, while we found taxa considered to be resilient, e.g. Heliopora and Porites, to exhibit severe bleaching, suggesting a reversal of bleaching hierarchies of taxa over time. Our findings provide a foundation for further coral bleaching studies in a region with few published records to enable more accurate regional assessments and to follow the trajectory of future coral bleaching events.", "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-007-0844-4", "doi": "10.1007/s00227-007-0844-4", "title": "Long-term changes in coral colony size distributions on Kenyan reefs under different management regimes and across the 1998 bleaching event", "publicationYear": 2008, "publicationDate": "2008-02", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "153", "issue": "5", "page": "755-768", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "T. R. McClanahan, M. Ateweberhan, J. Omukoto", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 69, "referenceCount": 58, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-007-0844-4", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-007-0844-4.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-011-1752-1", "doi": "10.1007/s00227-011-1752-1", "title": "Photoinhibition of Symbiodinium spp. within the reef corals Montastraea faveolata and Porites astreoides: implications for coral bleaching", "publicationYear": 2011, "publicationDate": "2011-11", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "158", "issue": "11", "page": "2515-2526", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Sebastian J. Hennige, Michael P. McGinley, Andréa G. Grottoli, Mark E. Warner", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 47, "referenceCount": 62, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-011-1752-1", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-011-1752-1.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1111/j.1365-2486.2009.02155.x", "doi": "10.1111/j.1365-2486.2009.02155.x", "title": "Interpreting the sign of coral bleaching as friend vs. foe", "publicationYear": 2011, "publicationDate": "2011-01", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Global Change Biology", "volume": "17", "issue": "1", "page": "45-55", "issn": "1354-1013", "isbn": null, "authors": "DAVID J. SUGGETT, DAVID J. SMITH", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 48, "referenceCount": 82, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1111/j.1365-2486.2009.02155.x", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-005-0230-z", "doi": "10.1007/s00227-005-0230-z", "title": "Increased mortality and photoinhibition in the symbiotic dinoflagellates of the Indo–Pacific coral Stylophora pistillata (Esper) after summer bleaching", "publicationYear": 2006, "publicationDate": "2006-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "149", "issue": "3", "page": "633-642", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Daniel J. Franklin, Cristina M. Molina Cedrés, Ove Hoegh-Guldberg", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 31, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-005-0230-z", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-005-0230-z.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1016/j.marpolbul.2023.114907", "doi": "10.1016/j.marpolbul.2023.114907", "title": "Differential bleaching susceptibility among coral taxa and colony sizes, relative to bleaching severity across Australia's Great Barrier Reef and Coral Sea Marine Parks", "publicationYear": 2023, "publicationDate": "2023-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Marine Pollution Bulletin", "volume": "191", "issue": null, "page": "114907", "issn": "0025-326X", "isbn": null, "authors": "D. Burn, A.S. Hoey, S. Matthews, H.B. Harrison, M.S. Pratchett", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 39, "referenceCount": 82, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.marpolbul.2023.114907", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-014-2509-4", "doi": "10.1007/s00227-014-2509-4", "title": "Growth and bleaching of the coral Oculina patagonica under different environmental conditions in the western Mediterranean Sea", "publicationYear": 2014, "publicationDate": "2014-10", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "161", "issue": "10", "page": "2333-2343", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Esther Rubio-Portillo, Maite Vázquez-Luis, Carlos Valle, Andrés Izquierdo-Muñoz, Alfonso A. Ramos-Esplá", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 12, "referenceCount": 47, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-014-2509-4", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-014-2509-4.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-005-0114-2", "doi": "10.1007/s00227-005-0114-2", "title": "Multi-year, seasonal genotypic surveys of coral-algal symbioses reveal prevalent stability or post-bleaching reversion", "publicationYear": 2006, "publicationDate": "2006-02", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "148", "issue": "4", "page": "711-722", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Daniel J. Thornhill, Todd C. LaJeunesse, Dustin W. Kemp, William K. Fitt, Gregory W. Schmidt", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 330, "referenceCount": 61, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-005-0114-2", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-005-0114-2.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.3354/meps09272", "doi": "10.3354/meps09272", "title": "Recolonisation of Acropora hyacinthus following climate-induced coral bleaching on the Great Barrier Reef", "publicationYear": 2011, "publicationDate": "2011-10-05", "type": "journal-article", "publisher": "Inter-Research Science Center", "containerTitle": "Marine Ecology Progress Series", "volume": "438", "issue": null, "page": "97-104", "issn": "0171-8630, 1616-1599", "isbn": null, "authors": "C Linares, MS Pratchett, DJ Coker", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 57, "referenceCount": 52, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3354/meps09272", "pdfUrl": "http://www.int-res.com/articles/meps2011/438/m438p097.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-014-2426-6", "doi": "10.1007/s00227-014-2426-6", "title": "Porites and the Phoenix effect: unprecedented recovery after a mass coral bleaching event at Rangiroa Atoll, French Polynesia", "publicationYear": 2014, "publicationDate": "2014-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "161", "issue": "6", "page": "1385-1393", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "George Roff, Sonia Bejarano, Yves-Marie Bozec, Maggy Nugues, Robert S. Steneck, Peter J. Mumby", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 51, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-014-2426-6", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-014-2426-6.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.29103/joms.v2i1.19332", "doi": "10.29103/joms.v2i1.19332", "title": "Coral gardening in a changing climate: Rapid assessment of the 4th recorded bleaching event at the Anantara Lagoon and reef system, South Male Atoll, Maldives", "publicationYear": 2024, "publicationDate": "2024-11-28", "type": "journal-article", "publisher": "LPPM Universitas Malikussaleh", "containerTitle": "Journal of Marine Studies", "volume": null, "issue": null, "page": "2101", "issn": "3047-406X", "isbn": null, "authors": "Oriana Migliaccio", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.29103/joms.v2i1.19332", "pdfUrl": "https://ojs.unimal.ac.id/JoMS/article/download/19332/pdf", "abstract": "Coral reefs are crucial to marine biodiversity and provide essential ecosystem services, but they face severe threats from climate change, particularly through coral bleaching events. The Maldives, renowned for its diverse coral reefs, has experienced increasing coral bleaching incidents, impacting both marine biodiversity and the tourism-dependent economy. This study investigates the effects of the 2024 coral bleaching event on coral nurseries within the Anantara Lagoon and reef system, South Male Atoll, Maldives. Monitoring was conducted across two coral nurseries in the lagoon and one coral nursery on the natural reef, focusing on species-specific responses to bleaching, predation, and survival rate. Results revealed variability in bleaching impacts among species and locations. Acropora aspera and Acropora muricata exhibited high mortality rates and increased predation, particularly at greater depths (~5 m), while Montipora digitata, Pocillopora damicornis, and Porites cylindrica showed greater resilience. The findings highlight the importance of adaptive management strategies for coral nurseries, emphasizing real-time environmental monitoring and strategic nursery placement to bolster coral reef resilience. This study underscores the need for integrated approaches combining coral restoration with broader reef management practices to enhance ecosystem recovery and sustainability.", "subject": null, "language": null, "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1016/j.margeo.2019.106041", "doi": "10.1016/j.margeo.2019.106041", "title": "Reef development on a remote coral atoll before and after coral bleaching: A geospatial assessment", "publicationYear": 2019, "publicationDate": "2019-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Marine Geology", "volume": "418", "issue": null, "page": "106041", "issn": "0025-3227", "isbn": null, "authors": "S.M. Hamylton, J. Mallela", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 12, "referenceCount": 61, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Australian Research Council", "funderIds": "10.13039/501100000923", "url": "https://doi.org/10.1016/j.margeo.2019.106041", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1016/0025-326x(88)90774-6", "doi": "10.1016/0025-326x(88)90774-6", "title": "Widespread coral bleaching in Caribbean", "publicationYear": 1988, "publicationDate": "1988-02", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Marine Pollution Bulletin", "volume": "19", "issue": "2", "page": "50", "issn": "0025-326X", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/0025-326x(88)90774-6", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1111/j.1365-2486.2010.02366.x", "doi": "10.1111/j.1365-2486.2010.02366.x", "title": "How much time can herbivore protection buy for coral reefs under realistic regimes of hurricanes and coral bleaching?", "publicationYear": 2011, "publicationDate": "2011-06", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Global Change Biology", "volume": "17", "issue": "6", "page": "2033-2048", "issn": "1354-1013", "isbn": null, "authors": "HELEN J. EDWARDS, IAN A. ELLIOTT, C. MARK EAKIN, AKIYUKI IRIKAWA, JOSHUA S. MADIN, MELANIE MCFIELD, JESSICA A. MORGAN, ROBERT Van WOESIK, PETER J. MUMBY", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 57, "referenceCount": 77, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1111/j.1365-2486.2010.02366.x", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1016/j.marenvres.2009.06.001", "doi": "10.1016/j.marenvres.2009.06.001", "title": "Hurricanes and coral bleaching linked to changes in coral recruitment in Tobago", "publicationYear": 2009, "publicationDate": "2009-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Marine Environmental Research", "volume": "68", "issue": "4", "page": "158-162", "issn": "0141-1136", "isbn": null, "authors": "J. Mallela, M.J.C. Crabbe", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 47, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.marenvres.2009.06.001", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-022-04091-2", "doi": "10.1007/s00227-022-04091-2", "title": "Rapid recovery of coral communities from a mass bleaching event in the summer of 2016, observed in Amitori Bay, Iriomote Island, Japan", "publicationYear": 2022, "publicationDate": "2022-08", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "169", "issue": "8", "page": null, "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Masako Nakamura, Tomokazu Murakami, Hiroyoshi Kohno, Akira Mizutani, Shinya Shimokawa", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 15, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": "jsps kakenhi, tokai university general research organaization grant", "funderIds": null, "url": "https://doi.org/10.1007/s00227-022-04091-2", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s00227-022-04091-2.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1046/j.1523-1739.2000.99145.x", "doi": "10.1046/j.1523-1739.2000.99145.x", "title": "Coral Bleaching and Global Climate Change: Scientific Findings and Policy Recommendations", "publicationYear": 2000, "publicationDate": "2000-10-18", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Conservation Biology", "volume": "14", "issue": "5", "page": "1500-1511", "issn": "0888-8892, 1523-1739", "isbn": null, "authors": "Jamie K. Reaser, Rafe Pomerance, Peter O. Thomas", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 99, "referenceCount": 99, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1046/j.1523-1739.2000.99145.x", "pdfUrl": null, "abstract": "Abstract: In 1998, tropical sea surface temperatures were the highest on record, topping off a 50‐year trend for some tropical oceans. In the same year, coral reefs around the world suffered the most extensive and severe bleaching ( loss of symbiotic algae) and subsequent mortality on record. These events may not be attributable to local stressors or natural variability alone but were likely induced by an underlying global phenomenon. It is probable that anthropogenic global warming has contributed to the extensive coral bleaching that has occurred simultaneously throughout the reef regions of the world. The geographic extent, increasing frequency, and regional severity of mass bleaching events are an apparent result of a steadily rising baseline of marine temperatures, combined with regionally specific El Niño and La Niña events. The repercussions of the 1998 mass bleaching and mortality events will be far‐reaching. Human populations dependent on reef services face losses of marine biodiversity, fisheries, and shoreline protection. Coral bleaching events may become more frequent and severe as the climate continues to warm, exposing coral reefs to an increasingly hostile environment. This global threat to corals compounds the effects of more localized anthropogenic factors that already place reefs at risk. Significant attention needs to be given to the monitoring of coral reef ecosystems, research on the projected and realized effects of global climate change, and measures to curtail greenhouse gas emissions. Even those reefs with well‐enforced legal protection as marine sanctuaries, or those managed for sustainable use, are threatened by global climate change.", "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.30564/jms.v2i2.1666", "doi": "10.30564/jms.v2i2.1666", "title": "Exhibition of bleaching resistance via adaptive bleaching pattern by coral reefs of the Gulf of Mannar during massive bleaching event 2019", "publicationYear": 2020, "publicationDate": "2020-06-30", "type": "journal-article", "publisher": "Bilingual Publishing Group", "containerTitle": "Journal of Marine Science", "volume": "2", "issue": "2", "page": null, "issn": "2661-3239", "isbn": null, "authors": "CH. Ramesh, S. Koushik, T. Shunmugaraj, M.V. Ramana Murthy", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.30564/jms.v2i2.1666", "pdfUrl": "https://ojs.bilpublishing.com/index.php/jms/article/viewFile/1666/1605", "abstract": "Coral reefs in the Gulf of Mannar (GoM) and Palk Bay regions are facing potential threats from climate change, sedimentation and anthropogenic activities. Considerably, coral reefs in these two regions are highly damaged due to frequent bleaching events caused by increased sea surface temperature (SST) recorded over the past two decades. Recently, during February to May 2019, mass bleaching event of corals was documented again in GoM and Palk Bay regions due to increased sea surface temperatures ranged between 32°C to 36°C. Despite of completely bleached corals, some coral colonies of the same bleached coral species have displayed adaptive bleaching pattern (ABP) for survival. This incidence is displayed by the symbiotic zooxanthellae to protect coral polyps from environmental stress such as elevated temperatures. These observations infer that coral colonies with preferential bleaching pattern ability would serve as environmental stress resisting coral colonies which can be used for restoration activities and cryopreservation. Further studies are needed to explain the potential mechanisms or specific environmental drivers responsible for ABP.", "subject": null, "language": null, "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1016/j.jembe.2012.01.014", "doi": "10.1016/j.jembe.2012.01.014", "title": "Influence of coral bleaching, coral mortality and conspecific aggression on movement and distribution of coral-dwelling fish", "publicationYear": 2012, "publicationDate": "2012-03", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Experimental Marine Biology and Ecology", "volume": "414-415", "issue": null, "page": "62-68", "issn": "0022-0981", "isbn": null, "authors": "Darren J. Coker, Morgan S. Pratchett, Philip L. Munday", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 40, "referenceCount": 69, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Ian Potter Cultural Trust, Centre of Excellence for Coral Reef Studies, Australian Research Council", "funderIds": "10.13039/501100001210, 10.13039/100014402", "url": "https://doi.org/10.1016/j.jembe.2012.01.014", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1016/s0025-326x(03)00037-7", "doi": "10.1016/s0025-326x(03)00037-7", "title": "Coral bleaching––how and why?", "publicationYear": 2003, "publicationDate": "2003-04", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Marine Pollution Bulletin", "volume": "46", "issue": "4", "page": "385-392", "issn": "0025-326X", "isbn": null, "authors": "A.E. Douglas", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 435, "referenceCount": 57, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0025-326x(03)00037-7", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1016/j.jembe.2009.02.016", "doi": "10.1016/j.jembe.2009.02.016", "title": "Effects of coral bleaching on the feeding response of two species of coral-feeding fish", "publicationYear": 2009, "publicationDate": "2009-05", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Experimental Marine Biology and Ecology", "volume": "373", "issue": "1", "page": "11-15", "issn": "0022-0981", "isbn": null, "authors": "A.J. Cole, M.S. Pratchett, G.P. Jones", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 33, "referenceCount": 49, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.jembe.2009.02.016", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-015-2633-9", "doi": "10.1007/s00227-015-2633-9", "title": "White but not bleached: photophysiological evidence from white Montastraea cavernosa reveals potential overestimation of coral bleaching", "publicationYear": 2015, "publicationDate": "2015-04", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "162", "issue": "4", "page": "889-899", "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Igor C. S. Cruz, Miguel C. Leal, Carlos R. Mendes, Ruy K. P. Kikuchi, Rui Rosa, Amadeu M. V. M. Soares, João Serôdio, Ricardo Calado, Rui J. M. Rocha", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 86, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s00227-015-2633-9", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-015-2633-9.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-021-03847-6", "doi": "10.1007/s00227-021-03847-6", "title": "Heating rate modulates the metabolic response of the staghorn coral Acropora cervicornis (Lamarck, 1816)", "publicationYear": 2021, "publicationDate": "2021-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "168", "issue": "6", "page": null, "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "Harmony A. Martell, Richard C. Zimmerman", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 15, "referenceCount": 59, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": "Generosity Crowdfunding Campaign, Old Dominion University Biology Graduate Student Organization, Old Dominion University", "funderIds": "10.13039/100009980", "url": "https://doi.org/10.1007/s00227-021-03847-6", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s00227-021-03847-6.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.3389/fmars.2020.00346", "doi": "10.3389/fmars.2020.00346", "title": "Commentary: Managing Recovery Resilience in Coral Reefs Against Climate-Induced Bleaching and Hurricanes: A 15 Year Case Study From Bonaire, Dutch Caribbean", "publicationYear": 2020, "publicationDate": "2020-06-04", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Marine Science", "volume": "7", "issue": null, "page": null, "issn": "2296-7745", "isbn": null, "authors": "Erik H. Meesters, Rolf P. M. Bak, Fleur C. van Duyl", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3389/fmars.2020.00346", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1007/s00227-019-3543-z", "doi": "10.1007/s00227-019-3543-z", "title": "Crown-of-thorns starfish impede the recovery potential of coral reefs following bleaching", "publicationYear": 2019, "publicationDate": "2019-07", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Marine Biology", "volume": "166", "issue": "7", "page": null, "issn": "0025-3162, 1432-1793", "isbn": null, "authors": "M. D. E. Haywood, D. P. Thomson, R. C. Babcock, R. D. Pillans, J. K. Keesing, M. Miller, W. A. Rochester, A. Donovan, R. D. Evans, G. Shedrawi, S. N. Field", "authorCount": 11, "firstAuthorAffiliation": null, "isReferencedByCount": 30, "referenceCount": 107, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": "Gorgon Barrow Island Net Conservation Benefits Fund", "funderIds": "10.13039/100012169", "url": "https://doi.org/10.1007/s00227-019-3543-z", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00227-019-3543-z.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1109/oceans.1988.794900", "doi": "10.1109/oceans.1988.794900", "title": "Disturbances in coral reefs: lessons from DIADEMA mass mortality and coral bleaching", "publicationYear": 1988, "publicationDate": "1988", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "OCEANS '88. 'A Partnership of Marine Interests'. Proceedings", "volume": null, "issue": null, "page": "803-807", "issn": null, "isbn": null, "authors": "C.F. D'Elia, P.R. Taylor", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/oceans.1988.794900", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.3389/fmars.2021.666825", "doi": "10.3389/fmars.2021.666825", "title": "Differential Symbiodiniaceae Association With Coral and Coral-Eroding Sponge in a Bleaching Impacted Marginal Coral Reef Environment", "publicationYear": 2021, "publicationDate": "2021-06-08", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Marine Science", "volume": "8", "issue": null, "page": null, "issn": "2296-7745", "isbn": null, "authors": "Sambhaji Mote, Vishal Gupta, Kalyan De, Afreen Hussain, Kuldeep More, Mandar Nanajkar, Baban Ingole", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 13, "referenceCount": 108, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3389/fmars.2021.666825", "pdfUrl": null, "abstract": "Marginal reefs are known for severe stress-inducible perturbations such as high sedimentation, eutrophication, ocean warming, and acidification from anthropogenic climate change. The corals striving in such stressful environments develop physiological adaptations induced by differential genomic expressions or association with thermal stress-tolerant algal symbionts (Symbiodiniaceae). Despite such adaptations, corals are threatened by other space competitors such as algae and sponges. Coral-eroding sponges belonging to the Cliona viridis complex are one such space competitors that also associate with Symbiodiniaceae algal photosymbiont. The diversity of Symbiodiniaceae associates with the coral and sponge from the same ecosystems is scarcely known. In the present study, Symbiodiniaceae community structure in the coral Turbinaria mesenterina, a newly described coral-eroding sponge Cliona thomasi, and their surrounding seawater was determined from the nearshore marginal reef along the central west coast of India. The results revealed a significantly higher relative abundance of Durusdinium and Gerakladium than Symbiodinium and Cladocopium in the seawater. Interestingly, both investigated host species showed differential Symbiodiniaceae association with significantly higher abundance of Durusdinium in coral and Gerakladium in sponge. The beta diversity analysis by Permutational multivariate analysis of variance (PERMANOVA) confirmed significant differences in Symbiodiniaceae profiles between sponge and coral. Durusdinium and Gerakladium are thermotolerant genera known to associate with different hosts in suboptimal conditions. Our field surveys suggested the bleaching resistance of the coral T. mesenterina despite the fact that the sea surface temperature reached the coral thermal threshold of 31°C during different periods of the years 2015, 2016, 2017, 2018, and 2019. Therefore, the thermal tolerance of the investigated coral and sponge species may be attributed to their respective thermotolerant photosymbiont associations. Furthermore, the results also indicated the host-specific photosymbiont selection from the local environment. Although these observations provide valuable biological insight, more research is needed to understand the tripartite association of sponge-coral-symbiont together to evaluate the competitive fitness of holobionts.", "subject": null, "language": null, "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1016/j.marenvres.2023.106152", "doi": "10.1016/j.marenvres.2023.106152", "title": "Optimized spatial and temporal pattern for coral bleaching heat stress alerts for China's coral reefs", "publicationYear": 2023, "publicationDate": "2023-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Marine Environmental Research", "volume": "191", "issue": null, "page": "106152", "issn": "0141-1136", "isbn": null, "authors": "Xiuling Zuo, Binni Qin, Juncan Teng, Xiaopeng Duan, Kefu Yu, Fenzhen Su", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 69, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.marenvres.2023.106152", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1046/j.1439-0485.2002.02773.x", "doi": "10.1046/j.1439-0485.2002.02773.x", "title": "Coral Recruitment and Regeneration on a Maldivian Reef 21 Months after the Coral Bleaching Event of 1998", "publicationYear": 2002, "publicationDate": "2002-09", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Marine Ecology", "volume": "23", "issue": "3", "page": "219-236", "issn": "0173-9565, 1439-0485", "isbn": null, "authors": "Karen Loch, Wolfgang Loch, Helmut Schuhmacher, Wolf R. See", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 45, "referenceCount": 36, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1046/j.1439-0485.2002.02773.x", "pdfUrl": null, "abstract": "Abstract. This paper describes the quantitative inventory of stony corals on a Maldivian reef after the bleaching event of 1998. The detailed data, collected in March 1999 and March 2000, comprise survival, new recruitment and regenerates. They were obtained in 6 transects laid out randomly on the reef flat, on 22 Acropora tables on 6 sites at the reef edge and on 39 Porites lobata blocks and 1 Diploastrea heliopora colony. The present cover of living zooxanthellate corals is reduced to ca. 2 – 5 % of its previous state. Acroporidae and Pocilloporidae were practically wiped out, while Poritidae survived partly and Agariciidae (esp. Pavona) are now the dominant group. New settlements on dead Acropora tables were mainly Agariciidae, followed by Acroporidae and Pocilloporidae. Regenerates on Porites were pronounced and the apparent yearly increase in mass was about threefold that of Diploastrea, which is 3 – 4 mm per year. The influence on reef ecology in terms of coral substrate and species, possible sources of larvae, change of guilds in reef builders, other species and the prospect for further development of the reef, with respect to growth versus erosion, is discussed.", "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1071/mf19220", "doi": "10.1071/mf19220", "title": "Diverse symbiont bleaching responses are evident from 2-degree heating week bleaching conditions as thermal stress intensifies in coral", "publicationYear": 2020, "publicationDate": "2020-08-26", "type": "journal-article", "publisher": "CSIRO Publishing", "containerTitle": "Marine and Freshwater Research", "volume": "71", "issue": "9", "page": "1149-1160", "issn": "1323-1650, 1448-6059", "isbn": null, "authors": "Sarah Gierz, Tracy D. Ainsworth, William Leggat", "authorCount": 3, "firstAuthorAffiliation": "AAustralian Research Council Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, Qld 4810, Australia.", "isReferencedByCount": 12, "referenceCount": 52, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.1071/journalslicense", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1071/mf19220", "pdfUrl": "https://connectsci.au/mf/article-pdf/71/9/1149/391986/mf19220.pdf", "abstract": "Coral bleaching is the dysfunction of the coral–algal endosymbiosis and is characterised as a loss of Symbiodiniaceae cells from host tissues or the loss of photosynthetic pigments. This breakdown of symbiosis occurs as a result of elevated temperature beyond the organism’s thermal threshold. The thermal tipping points within the symbiosis have not yet been well resolved, and the mechanisms underlying the various cellular processes of the corals bleaching response remain unknown. This study characterised the cellular responses of the symbiont Cladocopium sp. (syn. clade C3) within the host coral Acropora aspera during exposure to thermal stress. Exposure to temperatures between 2 and 3°C below the bleaching threshold, equating to 2-degree heating weeks (DHWs), results in changes to the symbiont cell morphology and cell division rates. Once corals were exposed to 4 DHWs, over 90% of the symbiont cells showed signs of degradation. Although sub-bleaching thermal stress is not sufficient to trigger bleaching alerts at an ecological scale, this stressor substantially affects the coral symbiosis. It is therefore vital that we begin to quantify how sub-bleaching thermal stress affects the fitness of Symbiodiniacea populations, their coral hosts and subsequently reefs worldwide.", "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1016/s0025-326x(00)00064-3", "doi": "10.1016/s0025-326x(00)00064-3", "title": "Bleaching Damage and Recovery Potential of Maldivian Coral Reefs", "publicationYear": 2000, "publicationDate": "2000-07", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Marine Pollution Bulletin", "volume": "40", "issue": "7", "page": "587-597", "issn": "0025-326X", "isbn": null, "authors": "T.R. McClanahan", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 123, "referenceCount": 68, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0025-326x(00)00064-3", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1111/gcb.70661", "doi": "10.1111/gcb.70661", "title": "Structural Climate Drivers of Global Coral Bleaching", "publicationYear": 2026, "publicationDate": "2026-01", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Global Change Biology", "volume": "32", "issue": "1", "page": null, "issn": "1354-1013, 1365-2486", "isbn": null, "authors": "Jungang Lu, Wenqi Xing, Huazhu Zheng, Zhengyu Yao, Nian Wei, Hongming He", "authorCount": 6, "firstAuthorAffiliation": "State Key Laboratory of Estuarine and Coastal Research East China Normal University  Shanghai China", "isReferencedByCount": 0, "referenceCount": 83, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": "National Natural Science Foundation of China", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.1111/gcb.70661", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/gcb.70661", "abstract": "ABSTRACT Mass coral bleaching has become a hallmark ecological signature of anthropogenic climate change, yet the structural mechanisms governing its spatial and temporal evolution remain poorly resolved. Traditional assessments emphasize surface thermal anomalies and strong El Niño phases but increasingly fail to explain the persistence of bleaching, its regional asymmetry, and the instability of ecological thresholds. Here, using long‐term datasets (1993–2020) of ocean temperature, bleaching alerts, El Niño–Southern Oscillation (ENSO) indices, coral–algal cover, and subsurface thermal profiles, we identify a regime shift from episodic bleaching toward chronic thermal exposure. This shift reflects a reduced dependence of bleaching on ENSO intensity, as even moderate ENSO phases, including both El Niño and La Niña events, are now associated with widespread bleaching, suggesting progressive erosion of thermal thresholds under sustained ocean warming. We further propose a “Structure–Pathway–Response” framework to capture the structural reconfiguration of bleaching risk: (i) heat convergence along eastern continental margins (e.g., East Asian Seas, Caribbean); (ii) poleward transport and topographic retention of subsurface heat along continental slopes; and (iii) vertical accumulation through isotherm deepening that elevates bleaching risk. We identify two dominant heat‐retention regimes: a current‐deflection mode in the Northern Hemisphere and a thermal‐stacking mode in the Southern Hemisphere. These patterns increase regional vulnerability by broadening the spatial extent and persistence of thermal anomalies, reflecting processes not fully captured by surface Sea Surface Temperature (SST) variability. Our findings highlight the limitations of surface‐only monitoring systems and underscore the need for thermodynamically informed, region‐specific early‐warning frameworks. Protecting structural thermal refugia and managing heat pathways will be critical for sustaining coral reef resilience in a rapidly warming ocean.", "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1155/2010/415167", "doi": "10.1155/2010/415167", "title": "Experimental Bleaching of a Reef-Building Coral Using a Simplified Recirculating Laboratory Exposure System", "publicationYear": 2010, "publicationDate": "2010", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Journal of Marine Biology", "volume": "2010", "issue": null, "page": "1-8", "issn": "1687-9481, 1687-949X", "isbn": null, "authors": "Mace G. Barron, Cheryl J. McGill, Lee A. Courtney, Dragoslav T. Marcovich", "authorCount": 4, "firstAuthorAffiliation": "Gulf Ecology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, 1 Sabine Island Drive, Gulf Breeze, FL 32561, USA", "isReferencedByCount": 8, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/3.0/", "funderNames": "U.S. Environmental Protection Agency", "funderIds": "10.13039/100000139", "url": "https://doi.org/10.1155/2010/415167", "pdfUrl": "http://downloads.hindawi.com/journals/jmb/2010/415167.pdf", "abstract": "Determining stressor-response relationships in reef building corals continues to be a critical research need due to global declines in coral reef ecosystems and projected declines for the future. A simplified recirculating coral exposure system was coupled to a solar simulator to allow laboratory testing of a diversity of species and morphologies of reef building corals under ecologically relevant conditions of temperature and solar radiation. Combinations of lamps and attenuating filters allowed for assignment of solar radiation treatments in experimental bleaching studies. Three bleaching experiments were performed using the reef building coral,Pocillopora damicornis, to assess the reproducibility of system performance and coral responses under control and stress conditions. Experiments showed consistent temperature- and solar radiation dependent-changes in pigment, numbers of symbiotic algae, photosystem II quantum yield, and tissue loss during exposure and recovery. The laboratory exposure system is recommended for use in experimental bleaching studies with reef building corals.", "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1016/j.marpolbul.2020.111008", "doi": "10.1016/j.marpolbul.2020.111008", "title": "Succession of delayed fluorescence correlated with coral bleaching in the hermatypic coral Acropora tenuis", "publicationYear": 2020, "publicationDate": "2020-05", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Marine Pollution Bulletin", "volume": "154", "issue": null, "page": "111008", "issn": "0025-326X", "isbn": null, "authors": "Ichiro Takeuchi, Daisuke Takaichi, Masakazu Katsumata, Hiroshi Ishibashi", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 11, "referenceCount": 48, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Japan Society for the Promotion of Science", "funderIds": "10.13039/501100001691", "url": "https://doi.org/10.1016/j.marpolbul.2020.111008", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "PD8DCDt4ewU3eewSJ", "_dataset_id": "Yaf2oiMLXHTljc0Wc"}
{"paperId": "10.1037/0021-9010.88.5.879", "doi": "10.1037/0021-9010.88.5.879", "title": "Common method biases in behavioral research: A critical review of the literature and recommended remedies.", "publicationYear": 2003, "publicationDate": "2003", "type": "journal-article", "publisher": "American Psychological Association (APA)", "containerTitle": "Journal of Applied Psychology", "volume": "88", "issue": "5", "page": "879-903", "issn": "1939-1854, 0021-9010", "isbn": null, "authors": "Philip M. Podsakoff, Scott B. MacKenzie, Jeong-Yeon Lee, Nathan P. Podsakoff", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 67562, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1037/0021-9010.88.5.879", "pdfUrl": "http://psycnet.apa.org/journals/apl/88/5/879.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1016/0749-5978(91)90020-t", "doi": "10.1016/0749-5978(91)90020-t", "title": "The theory of planned behavior", "publicationYear": 1991, "publicationDate": "1991-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Organizational Behavior and Human Decision Processes", "volume": "50", "issue": "2", "page": "179-211", "issn": "0749-5978", "isbn": null, "authors": "Icek Ajzen", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 67196, "referenceCount": 100, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/0749-5978(91)90020-t", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.3758/bf03193146", "doi": "10.3758/bf03193146", "title": "G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences", "publicationYear": 2007, "publicationDate": "2007-05", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Behavior Research Methods", "volume": "39", "issue": "2", "page": "175-191", "issn": "1554-351X, 1554-3528", "isbn": null, "authors": "Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 54633, "referenceCount": 70, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3758/bf03193146", "pdfUrl": "http://link.springer.com/content/pdf/10.3758/BF03193146.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1037/0033-295x.84.2.191", "doi": "10.1037/0033-295x.84.2.191", "title": "Self-efficacy: Toward a unifying theory of behavioral change.", "publicationYear": 1977, "publicationDate": "1977", "type": "journal-article", "publisher": "American Psychological Association (APA)", "containerTitle": "Psychological Review", "volume": "84", "issue": "2", "page": "191-215", "issn": "1939-1471, 0033-295X", "isbn": null, "authors": "Albert Bandura", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 50545, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1037/0033-295x.84.2.191", "pdfUrl": "http://psycnet.apa.org/journals/rev/84/2/191.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.2307/1914185", "doi": "10.2307/1914185", "title": "Prospect Theory: An Analysis of Decision under Risk", "publicationYear": 1979, "publicationDate": "1979-03", "type": "journal-article", "publisher": "JSTOR", "containerTitle": "Econometrica", "volume": "47", "issue": "2", "page": "263", "issn": "0012-9682", "isbn": null, "authors": "Daniel Kahneman, Amos Tversky", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 40231, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1914185", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1016/0377-2217(78)90138-8", "doi": "10.1016/0377-2217(78)90138-8", "title": "Measuring the efficiency of decision making units", "publicationYear": 1978, "publicationDate": "1978-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "European Journal of Operational Research", "volume": "2", "issue": "6", "page": "429-444", "issn": "0377-2217", "isbn": null, "authors": "A. Charnes, W.W. Cooper, E. Rhodes", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 21790, "referenceCount": 28, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/0377-2217(78)90138-8", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.4324/9780203771587", "doi": "10.4324/9780203771587", "title": "Statistical Power Analysis for the Behavioral Sciences", "publicationYear": 2013, "publicationDate": "2013-05-13", "type": "book", "publisher": "Routledge", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9781134742707", "authors": "Jacob Cohen", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 16881, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4324/9780203771587", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1006/jcss.1997.1504", "doi": "10.1006/jcss.1997.1504", "title": "A Decision-Theoretic Generalization of On-Line Learning and an Application to Boosting", "publicationYear": 1997, "publicationDate": "1997-08", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Computer and System Sciences", "volume": "55", "issue": "1", "page": "119-139", "issn": "0022-0000", "isbn": null, "authors": "Yoav Freund, Robert E Schapire", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 13685, "referenceCount": 26, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1006/jcss.1997.1504", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1080/00273171.2011.568786", "doi": "10.1080/00273171.2011.568786", "title": "An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies", "publicationYear": 2011, "publicationDate": "2011-05-31", "type": "journal-article", "publisher": "Informa UK Limited", "containerTitle": "Multivariate Behavioral Research", "volume": "46", "issue": "3", "page": "399-424", "issn": "0027-3171, 1532-7906", "isbn": null, "authors": "Peter C. Austin", "authorCount": 1, "firstAuthorAffiliation": "Policy and Evaluation, University of Toronto", "isReferencedByCount": 10541, "referenceCount": 83, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1080/00273171.2011.568786", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.2307/1884852", "doi": "10.2307/1884852", "title": "A Behavioral Model of Rational Choice", "publicationYear": 1955, "publicationDate": "1955-02", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "The Quarterly Journal of Economics", "volume": "69", "issue": "1", "page": "99", "issn": "0033-5533", "isbn": null, "authors": "Herbert A. Simon", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 10006, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1884852", "pdfUrl": "http://academic.oup.com/qje/article-pdf/69/1/99/5413375/69-1-99.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1207/s15327906mbr0102_10", "doi": "10.1207/s15327906mbr0102_10", "title": "The Scree Test For The Number Of Factors", "publicationYear": 1966, "publicationDate": "1966-04", "type": "journal-article", "publisher": "Informa UK Limited", "containerTitle": "Multivariate Behavioral Research", "volume": "1", "issue": "2", "page": "245-276", "issn": "0027-3171, 1532-7906", "isbn": null, "authors": "Raymond B. Cattell", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 9650, "referenceCount": 31, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1207/s15327906mbr0102_10", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1017/s0140525x0999152x", "doi": "10.1017/s0140525x0999152x", "title": "The weirdest people in the world?", "publicationYear": 2010, "publicationDate": "2010-06", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Behavioral and Brain Sciences", "volume": "33", "issue": "2-3", "page": "61-83", "issn": "0140-525X, 1469-1825", "isbn": null, "authors": "Joseph Henrich, Steven J. Heine, Ara Norenzayan", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 9608, "referenceCount": 296, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/s0140525x0999152x", "pdfUrl": null, "abstract": "AbstractBehavioral scientists routinely publish broad claims about human psychology and behavior in the world's top journals based on samples drawn entirely from Western, Educated, Industrialized, Rich, and Democratic (WEIRD) societies. Researchers – often implicitly – assume that either there is little variation across human populations, or that these “standard subjects” are as representative of the species as any other population. Are these assumptions justified? Here, our review of the comparative database from across the behavioral sciences suggests both that there is substantial variability in experimental results across populations and that WEIRD subjects are particularly unusual compared with the rest of the species – frequent outliers. The domains reviewed include visual perception, fairness, cooperation, spatial reasoning, categorization and inferential induction, moral reasoning, reasoning styles, self-concepts and related motivations, and the heritability of IQ. The findings suggest that members of WEIRD societies, including young children, are among the least representative populations one could find for generalizing about humans. Many of these findings involve domains that are associated with fundamental aspects of psychology, motivation, and behavior – hence, there are no obviousa priorigrounds for claiming that a particular behavioral phenomenon is universal based on sampling from a single subpopulation. Overall, these empirical patterns suggests that we need to be less cavalier in addressing questions ofhumannature on the basis of data drawn from this particularly thin, and rather unusual, slice of humanity. We close by proposing ways to structurally re-organize the behavioral sciences to best tackle these challenges.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1007/bf00116251", "doi": "10.1007/bf00116251", "title": "Induction of decision trees", "publicationYear": 1986, "publicationDate": "1986-03", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Machine Learning", "volume": "1", "issue": "1", "page": "81-106", "issn": "0885-6125, 1573-0565", "isbn": null, "authors": "J. R. Quinlan", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 9139, "referenceCount": 35, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/bf00116251", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/BF00116251.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.2307/2392498", "doi": "10.2307/2392498", "title": "Job Demands, Job Decision Latitude, and Mental Strain: Implications for Job Redesign", "publicationYear": 1979, "publicationDate": "1979-06", "type": "journal-article", "publisher": "JSTOR", "containerTitle": "Administrative Science Quarterly", "volume": "24", "issue": "2", "page": "285", "issn": "0001-8392", "isbn": null, "authors": "Robert A. Karasek", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 8647, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2392498", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1080/00273170701341316", "doi": "10.1080/00273170701341316", "title": "Addressing Moderated Mediation Hypotheses: Theory, Methods, and Prescriptions", "publicationYear": 2007, "publicationDate": "2007-06-29", "type": "journal-article", "publisher": "Informa UK Limited", "containerTitle": "Multivariate Behavioral Research", "volume": "42", "issue": "1", "page": "185-227", "issn": "0027-3171, 1532-7906", "isbn": null, "authors": "Kristopher J. Preacher, Derek D. Rucker, Andrew F. Hayes", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 8248, "referenceCount": 67, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1080/00273170701341316", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1177/002224299606000203", "doi": "10.1177/002224299606000203", "title": "The Behavioral Consequences of Service Quality", "publicationYear": 1996, "publicationDate": "1996-04", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Journal of Marketing", "volume": "60", "issue": "2", "page": "31-46", "issn": "0022-2429, 1547-7185", "isbn": null, "authors": "Valarie A. Zeithaml, Leonard L. Berry, A. Parasuraman", "authorCount": 3, "firstAuthorAffiliation": "Partners for Service Excellence, a consulting firm specializing in strategy, measurement, and implementation of service quality.", "isReferencedByCount": 7534, "referenceCount": 47, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/002224299606000203", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/002224299606000203", "abstract": "If service quality relates to retention of customers at the aggregate level, as other research has indicated, then evidence of its impact on customers’ behavioral responses should be detectable. The authors offer a conceptual model of the impact of service quality on particular behaviors that signal whether customers remain with or defect from a company. Results from a multicompany empirical study examining relationships from the model concerning customers’ behavioral intentions show strong evidence of their being influenced by service quality. The findings also reveal differences in the nature of the quality-intentions link across different dimensions of behavioral intentions. The authors’ discussion centers on ways the results and research approach of their study can be helpful to researchers and managers.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.2307/2137284", "doi": "10.2307/2137284", "title": "Revisiting the Behavioral Model and Access to Medical Care: Does it Matter?", "publicationYear": 1995, "publicationDate": "1995-03", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Journal of Health and Social Behavior", "volume": "36", "issue": "1", "page": "1", "issn": "0022-1465", "isbn": null, "authors": "Ronald M. Andersen", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 7425, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2137284", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1023/b-joba.0000007455.08539.94", "doi": "10.1023/b:joba.0000007455.08539.94", "title": "Multidimensional Assessment of Emotion Regulation and Dysregulation: Development, Factor Structure, and Initial Validation of the Difficulties in Emotion Regulation Scale", "publicationYear": 2004, "publicationDate": "2004-03", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Journal of Psychopathology and Behavioral Assessment", "volume": "26", "issue": "1", "page": "41-54", "issn": "0882-2689, 1573-3505", "isbn": null, "authors": "Kim L. Gratz, Lizabeth Roemer", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 7300, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1023/b:joba.0000007455.08539.94", "pdfUrl": "https://link.springer.com/content/pdf/10.1023/B:JOBA.0000007455.08539.94.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1007/978-3-030-00889-5_1", "doi": "10.1007/978-3-030-00889-5_1", "title": "UNet++: A Nested U-Net Architecture for Medical Image Segmentation", "publicationYear": 2018, "publicationDate": "2018", "type": "book-chapter", "publisher": "Springer International Publishing", "containerTitle": "Lecture Notes in Computer Science", "volume": null, "issue": null, "page": "3-11", "issn": "0302-9743, 1611-3349", "isbn": "9783030008888, 9783030008895", "authors": "Zongwei Zhou, Md Mahfuzur Rahman Siddiquee, Nima Tajbakhsh, Jianming Liang", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 7236, "referenceCount": 11, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-3-030-00889-5_1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1016/0377-2217(90)90057-i", "doi": "10.1016/0377-2217(90)90057-i", "title": "How to make a decision: The analytic hierarchy process", "publicationYear": 1990, "publicationDate": "1990-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "European Journal of Operational Research", "volume": "48", "issue": "1", "page": "9-26", "issn": "0377-2217", "isbn": null, "authors": "Thomas L. Saaty", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 7219, "referenceCount": 15, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/0377-2217(90)90057-i", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1007/978-3-642-48318-9", "doi": "10.1007/978-3-642-48318-9", "title": "Multiple Attribute Decision Making", "publicationYear": 1981, "publicationDate": "1981", "type": "book", "publisher": "Springer Berlin Heidelberg", "containerTitle": "Lecture Notes in Economics and Mathematical Systems", "volume": null, "issue": null, "page": null, "issn": "0075-8442", "isbn": "9783540105589, 9783642483189", "authors": "Ching-Lai Hwang, Kwangsun Yoon", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 6748, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-3-642-48318-9", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/978-3-642-48318-9.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1007/s12160-013-9486-6", "doi": "10.1007/s12160-013-9486-6", "title": "The Behavior Change Technique Taxonomy (v1) of 93 Hierarchically Clustered Techniques: Building an International Consensus for the Reporting of Behavior Change Interventions", "publicationYear": 2013, "publicationDate": "2013-08", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Annals of Behavioral Medicine", "volume": "46", "issue": "1", "page": "81-95", "issn": "0883-6612, 1532-4796", "isbn": null, "authors": "Susan Michie, Michelle Richardson, Marie Johnston, Charles Abraham, Jill Francis, Wendy Hardeman, Martin P. Eccles, James Cane, Caroline E. Wood", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 6514, "referenceCount": 48, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s12160-013-9486-6", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1207/s15327906mbr3901_4", "doi": "10.1207/s15327906mbr3901_4", "title": "Confidence Limits for the Indirect Effect: Distribution of the Product and Resampling Methods", "publicationYear": 2004, "publicationDate": "2004-01", "type": "journal-article", "publisher": "Informa UK Limited", "containerTitle": "Multivariate Behavioral Research", "volume": "39", "issue": "1", "page": "99-128", "issn": "0027-3171, 1532-7906", "isbn": null, "authors": "David P. MacKinnon, Chondra M. Lockwood, Jason Williams", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 6294, "referenceCount": 65, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1207/s15327906mbr3901_4", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1139/z90-092", "doi": "10.1139/z90-092", "title": "Behavioral decisions made under the risk of predation: a review and prospectus", "publicationYear": 1990, "publicationDate": "1990-04-01", "type": "journal-article", "publisher": "Canadian Science Publishing", "containerTitle": "Canadian Journal of Zoology", "volume": "68", "issue": "4", "page": "619-640", "issn": "0008-4301, 1480-3283", "isbn": null, "authors": "Steven L. Lima, Lawrence M. Dill", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 6294, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1139/z90-092", "pdfUrl": null, "abstract": "Predation has long been implicated as a major selective force in the evolution of several morphological and behavioral characteristics of animals. The importance of predation during evolutionary time is clear, but growing evidence suggests that animals also have the ability to assess and behaviorally influence their risk of being preyed upon in ecological time (i.e., during their lifetime). We develop an abstraction of the predation process in which several components of predation risk are identified. A review of the literature indicates that an animal's ability to assess and behaviorally control one or more of these components strongly influences decision making in feeding animals, as well as in animals deciding when and how to escape predators, when and how to be social, or even, for fishes, when and how to breathe air. This review also reveals that such decision making reflects apparent trade-offs between the risk of predation and the benefits to be gained from engaging in a given activity. Despite this body of evidence, several areas in the study of animal behavior have received little or no attention from a predation perspective. We identify several such areas, the most important of which is that dealing with animal reproduction. Much work also remains regarding the precise nature of the risk of predation and how it is actually perceived by animals, and the extent to which they can behaviorally control their risk of predation. Mathematical models will likely play a major role in future work, and we suggest that modelers strive to consider the potential complexity in behavioral responses to predation risk. Overall, since virtually every animal is potential prey for others, research that seriously considers the influence of predation risk will provide significant insight into the nature of animal behavior.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1109/tsmc.1973.5408575", "doi": "10.1109/tsmc.1973.5408575", "title": "Outline of a New Approach to the Analysis of Complex Systems and Decision Processes", "publicationYear": 1973, "publicationDate": "1973", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Systems, Man, and Cybernetics", "volume": "SMC-3", "issue": "1", "page": "28-44", "issn": "0018-9472", "isbn": null, "authors": "Lotfi A. Zadeh", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 6258, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tsmc.1973.5408575", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.2307/258867", "doi": "10.2307/258867", "title": "Ethical Decision Making by Individuals in Organizations: An Issue-Contingent Model", "publicationYear": 1991, "publicationDate": "1991-04", "type": "journal-article", "publisher": "Academy of Management", "containerTitle": "The Academy of Management Review", "volume": "16", "issue": "2", "page": "366", "issn": "0363-7425", "isbn": null, "authors": "Thomas M. Jones", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 6095, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/258867", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1111/j.1540-5915.2008.00192.x", "doi": "10.1111/j.1540-5915.2008.00192.x", "title": "Technology Acceptance Model 3 and a Research Agenda on Interventions", "publicationYear": 2008, "publicationDate": "2008-05", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Decision Sciences", "volume": "39", "issue": "2", "page": "273-315", "issn": "0011-7315, 1540-5915", "isbn": null, "authors": "Viswanath Venkatesh, Hillol Bala", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 5971, "referenceCount": 122, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1111/j.1540-5915.2008.00192.x", "pdfUrl": null, "abstract": "ABSTRACTPrior research has provided valuable insights into how and why employees make a decision about the adoption and use of information technologies (ITs) in the workplace. From an organizational point of view, however, the more important issue is how managers make informed decisions about interventions that can lead to greater acceptance and effective utilization of IT. There is limited research in the IT implementation literature that deals with the role of interventions to aid such managerial decision making. Particularly, there is a need to understand how various interventions can influence the known determinants of IT adoption and use. To address this gap in the literature, we draw from the vast body of research on the technology acceptance model (TAM), particularly the work on the determinants of perceived usefulness and perceived ease of use, and: (i) develop a comprehensive nomological network (integrated model) of the determinants of individual level (IT) adoption and use; (ii) empirically test the proposed integrated model; and (iii) present a research agenda focused on potential pre‐ and postimplementation interventions that can enhance employees' adoption and use of IT. Our findings and research agenda have important implications for managerial decision making on IT implementation in organizations.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1287/mnsc.17.4.b141", "doi": "10.1287/mnsc.17.4.b141", "title": "Decision-Making in a Fuzzy Environment", "publicationYear": 1970, "publicationDate": "1970-12", "type": "journal-article", "publisher": "Institute for Operations Research and the Management Sciences (INFORMS)", "containerTitle": "Management Science", "volume": "17", "issue": "4", "page": "B-141-B-164", "issn": "0025-1909, 1526-5501", "isbn": null, "authors": "R. E. Bellman, L. A. Zadeh", "authorCount": 2, "firstAuthorAffiliation": "University of Southern California", "isReferencedByCount": 5896, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1287/mnsc.17.4.b141", "pdfUrl": null, "abstract": "By decision-making in a fuzzy environment is meant a decision process in which the goals and/or the constraints, but not necessarily the system under control, are fuzzy in nature. This means that the goals and/or the constraints constitute classes of alternatives whose boundaries are not sharply defined. An example of a fuzzy constraint is: “The cost of A should not be substantially higher than α,” where α is a specified constant. Similarly, an example of a fuzzy goal is: “x should be in the vicinity of x0 ,” where x0 is a constant. The italicized words are the sources of fuzziness in these examples. Fuzzy goals and fuzzy constraints can be defined precisely as fuzzy sets in the space of alternatives. A fuzzy decision, then, may be viewed as an intersection of the given goals and constraints. A maximizing decision is defined as a point in the space of alternatives at which the membership function of a fuzzy decision attains its maximum value. The use of these concepts is illustrated by examples involving multistage decision processes in which the system under control is either deterministic or stochastic. By using dynamic programming, the determination of a maximizing decision is reduced to the solution of a system of functional equations. A reverse-flow technique is described for the solution of a functional equation arising in connection with a decision process in which the termination time is defined implicitly by the condition that the process stops when the system under control enters a specified set of states in its state space.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1207/s15327558ijbm0401_6", "doi": "10.1207/s15327558ijbm0401_6", "title": "You want to measure coping but your protocol’ too long: Consider the brief cope", "publicationYear": 1997, "publicationDate": "1997-03", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "International Journal of Behavioral Medicine", "volume": "4", "issue": "1", "page": "92-100", "issn": "1070-5503, 1532-7558", "isbn": null, "authors": "Charles S. Carver", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5756, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1207/s15327558ijbm0401_6", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1207/s15327906mbr2502_4", "doi": "10.1207/s15327906mbr2502_4", "title": "Structural Model Evaluation and Modification: An Interval Estimation Approach", "publicationYear": 1990, "publicationDate": "1990-04", "type": "journal-article", "publisher": "Informa UK Limited", "containerTitle": "Multivariate Behavioral Research", "volume": "25", "issue": "2", "page": "173-180", "issn": "0027-3171, 1532-7906", "isbn": null, "authors": "James H. Steiger", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5637, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1207/s15327906mbr2502_4", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1017/s0140525x00076512", "doi": "10.1017/s0140525x00076512", "title": "Does the chimpanzee have a theory of mind?", "publicationYear": 1978, "publicationDate": "1978-12", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Behavioral and Brain Sciences", "volume": "1", "issue": "4", "page": "515-526", "issn": "0140-525X, 1469-1825", "isbn": null, "authors": "David Premack, Guy Woodruff", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 5576, "referenceCount": 8, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/s0140525x00076512", "pdfUrl": null, "abstract": "AbstractAn individual has a theory of mind if he imputes mental states to himself and others. A system of inferences of this kind is properly viewed as a theory because such states are not directly observable, and the system can be used to make predictions about the behavior of others. As to the mental states the chimpanzee may infer, consider those inferred by our own species, for example, purpose or intention, as well as knowledge, belief, thinking, doubt, guessing, pretending, liking, and so forth. To determine whether or not the chimpanzee infers states of this kind, we showed an adult chimpanzee a series of videotaped scenes of a human actor struggling with a variety of problems. Some problems were simple, involving inaccessible food – bananas vertically or horizontally out of reach, behind a box, and so forth – as in the original Kohler problems; others were more complex, involving an actor unable to extricate himself from a locked cage, shivering because of a malfunctioning heater, or unable to play a phonograph because it was unplugged. With each videotape the chimpanzee was given several photographs, one a solution to the problem, such as a stick for the inaccessible bananas, a key for the locked up actor, a lit wick for the malfunctioning heater. The chimpanzee's consistent choice of the correct photographs can be understood by assuming that the animal recognized the videotape as representing a problem, understood the actor's purpose, and chose alternatives compatible with that purpose.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1111/j.1559-1816.2002.tb00236.x", "doi": "10.1111/j.1559-1816.2002.tb00236.x", "title": "Perceived Behavioral Control, Self‐Efficacy, Locus of Control, and the Theory of Planned Behavior<sup>1</sup>", "publicationYear": 2002, "publicationDate": "2002-04", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Journal of Applied Social Psychology", "volume": "32", "issue": "4", "page": "665-683", "issn": "0021-9029, 1559-1816", "isbn": null, "authors": "Icek Ajzen", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5575, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1111/j.1559-1816.2002.tb00236.x", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1559-1816.2002.tb00236.x", "abstract": "Conceptual and methodological ambiguities surrounding the concept of perceived behavioral control are clarified. It is shown that perceived control over performance of a behavior, though comprised of separable components that reflect beliefs about self‐efficacy and about controllability, can nevertheless be considered a unitary latent variable in a hierarchical factor model. It is further argued that there is no necessary correspondence between self‐efficacy and internal control factors, or between controllability and external control factors. Self‐efficacy and controllability can reflect internal as well as external factors and the extent to which they reflect one or the other is an empirical question. Finally, a case is made that measures of perceived behavioral control need to incorporate self‐efficacy as well as controllability items that are carefully selected to ensure high internal consistency.Summary and ConclusionsPerceived control over performance of a behavior can account for consider‐ able variance in intentions and actions. However, ambiguities surrounding the concept of perceived behavioral control have tended to create uncertainties and to impede progress. The present article attempted to clarify conceptual ambiguities and resolve issues related to the operationalization of perceived behavioral control. Recent research has demonstrated that the overarching concept of perceived behavioral control, as commonly assessed, is comprised of two components: self‐efficacy (dealing largely with the ease or difficulty of performing a behavior) and controllability (the extent to which performance is up to the actor). Contrary to a widely accepted view, it was argued that self‐efficacy expectations do not necessarily correspond to beliefs about internal control factors, and that controllability expectations have no necessary basis in the perceived operation of external factors. Instead, it was suggested that self‐efficacy and controllability may both reflect beliefs about the presence of internal as well as external factors. Rather than making a priori assumptions about the internal or external locus of self‐efficacy and controllability, this issue is best treated as an empirical question.Also of theoretical significance, the present article tried to dispel the notion that self‐efficacy and controllability are incompatible with, or independent of, each other. Although factor analyses of perceived behavioral control items provide clear and consistent evidence for the distinction, there is sufficient commonality between self‐efficacy and controllability to suggest a two‐level hierarchical model. In this model, perceived behavioral control is the overarching, superordinate construct that is comprised of two lower‐level components: self‐efficacy and controllability. This view of the control component in the theory of planned behavior implies that measures of perceived behavioral control should contain items that assess self‐efficacy as well as controllability. Depending on the purpose of the investigation, a decision can be made to aggregate over all items, treating perceived behavioral control as a unitary factor, or to distinguish between self‐efficacy and controllability by entering separate indices into the prediction equation.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1037/0022-3514.67.2.319", "doi": "10.1037/0022-3514.67.2.319", "title": "Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: The BIS/BAS Scales.", "publicationYear": 1994, "publicationDate": "1994-08", "type": "journal-article", "publisher": "American Psychological Association (APA)", "containerTitle": "Journal of Personality and Social Psychology", "volume": "67", "issue": "2", "page": "319-333", "issn": "1939-1315, 0022-3514", "isbn": null, "authors": "Charles S. Carver, Teri L. White", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 5479, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1037/0022-3514.67.2.319", "pdfUrl": "http://psycnet.apa.org/journals/psp/67/2/319.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1109/34.709601", "doi": "10.1109/34.709601", "title": "The random subspace method for constructing decision forests", "publicationYear": 1998, "publicationDate": "1998", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Pattern Analysis and Machine Intelligence", "volume": "20", "issue": "8", "page": "832-844", "issn": "0162-8828", "isbn": null, "authors": "Tin Kam Ho", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5374, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/34.709601", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1037/0033-2909.121.1.65", "doi": "10.1037/0033-2909.121.1.65", "title": "Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD.", "publicationYear": 1997, "publicationDate": "1997-01", "type": "journal-article", "publisher": "American Psychological Association (APA)", "containerTitle": "Psychological Bulletin", "volume": "121", "issue": "1", "page": "65-94", "issn": "1939-1455, 0033-2909", "isbn": null, "authors": "Russell A. Barkley", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5295, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1037/0033-2909.121.1.65", "pdfUrl": "http://psycnet.apa.org/journals/bul/121/1/65.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1080/10705500802222972", "doi": "10.1080/10705500802222972", "title": "The brief resilience scale: Assessing the ability to bounce back", "publicationYear": 2008, "publicationDate": "2008-09", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "International Journal of Behavioral Medicine", "volume": "15", "issue": "3", "page": "194-200", "issn": "1070-5503, 1532-7558", "isbn": null, "authors": "Bruce W. Smith, Jeanne Dalen, Kathryn Wiggins, Erin Tooley, Paulette Christopher, Jennifer Bernard", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 5278, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1080/10705500802222972", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1177/0272989x06295361", "doi": "10.1177/0272989x06295361", "title": "Decision Curve Analysis: A Novel Method for Evaluating Prediction Models", "publicationYear": 2006, "publicationDate": "2006-11", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Medical Decision Making", "volume": "26", "issue": "6", "page": "565-574", "issn": "0272-989X, 1552-681X", "isbn": null, "authors": "Andrew J. Vickers, Elena B. Elkin", "authorCount": 2, "firstAuthorAffiliation": "Department of Epidemiology and Biostatistics, Department of Urology, and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York; .", "isReferencedByCount": 4845, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/0272989x06295361", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/0272989X06295361", "abstract": "Background. Diagnostic and prognostic models are typically evaluated with measures of accuracy that do not address clinical consequences. Decision-analytic techniques allow assessment of clinical outcomes but often require collection of additional information and may be cumbersome to apply to models that yield a continuous result. The authors sought a method for evaluating and comparing prediction models that incorporates clinical consequences, requires only the data set on which the models are tested, and can be applied to models that have either continuous or dichotomous results. Method. The authors describe decision curve analysis, a simple, novel method of evaluating predictive models. They start by assuming that the threshold probability of a disease or event at which a patient would opt for treatment is informative of how the patient weighs the relative harms of a false-positive and a false-negative prediction. This theoretical relationship is then used to derive the net benefit of the model across different threshold probabilities. Plotting net benefit against threshold probability yields the “decision curve.” The authors apply the method to models for the prediction of seminal vesicle invasion in prostate cancer patients. Decision curve analysis identified the range of threshold probabilities in which a model was of value, the magnitude of benefit, and which of several models was optimal. Conclusion. Decision curve analysis is a suitable method for evaluating alternative diagnostic and prognostic strategies that has advantages over other commonly used measures and techniques.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1016/0749-5978(91)90022-l", "doi": "10.1016/0749-5978(91)90022-l", "title": "Social cognitive theory of self-regulation", "publicationYear": 1991, "publicationDate": "1991-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Organizational Behavior and Human Decision Processes", "volume": "50", "issue": "2", "page": "248-287", "issn": "0749-5978", "isbn": null, "authors": "Albert Bandura", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4775, "referenceCount": 104, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/0749-5978(91)90022-l", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1504/ijssci.2008.017590", "doi": "10.1504/ijssci.2008.017590", "title": "Decision making with the analytic hierarchy process", "publicationYear": 2008, "publicationDate": "2008", "type": "journal-article", "publisher": "Inderscience Publishers", "containerTitle": "International Journal of Services Sciences", "volume": "1", "issue": "1", "page": "83", "issn": "1753-1446, 1753-1454", "isbn": null, "authors": "Thomas L. Saaty", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4752, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1504/ijssci.2008.017590", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.3389/fpubh.2018.00149", "doi": "10.3389/fpubh.2018.00149", "title": "Best Practices for Developing and Validating Scales for Health, Social, and Behavioral Research: A Primer", "publicationYear": 2018, "publicationDate": "2018-06-11", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Public Health", "volume": "6", "issue": null, "page": null, "issn": "2296-2565", "isbn": null, "authors": "Godfred O. Boateng, Torsten B. Neilands, Edward A. Frongillo, Hugo R. Melgar-Quiñonez, Sera L. Young", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 4602, "referenceCount": 141, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Institute of Mental Health", "funderIds": "10.13039/100000025", "url": "https://doi.org/10.3389/fpubh.2018.00149", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1017/s0140525x01003922", "doi": "10.1017/s0140525x01003922", "title": "The magical number 4 in short-term memory: A reconsideration of mental storage capacity", "publicationYear": 2001, "publicationDate": "2001-02", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Behavioral and Brain Sciences", "volume": "24", "issue": "1", "page": "87-114", "issn": "0140-525X, 1469-1825", "isbn": null, "authors": "Nelson Cowan", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4599, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/s0140525x01003922", "pdfUrl": null, "abstract": "Miller (1956) summarized evidence that people can remember about seven chunks in short-term memory (STM) tasks. However, that number was meant more as a rough estimate and a rhetorical device than as a real capacity limit. Others have since suggested that there is a more precise capacity limit, but that it is only three to five chunks. The present target article brings together a wide variety of data on capacity limits suggesting that the smaller capacity limit is real. Capacity limits will be useful in analyses of information processing only if the boundary conditions for observing them can be carefully described. Four basic conditions in which chunks can be identified and capacity limits can accordingly be observed are: (1) when information overload limits chunks to individual stimulus items, (2) when other steps are taken specifically to block the recoding of stimulus items into larger chunks, (3) in performance discontinuities caused by the capacity limit, and (4) in various indirect effects of the capacity limit. Under these conditions, rehearsal and long-term memory cannot be used to combine stimulus items into chunks of an unknown size; nor can storage mechanisms that are not capacity-limited, such as sensory memory, allow the capacity-limited storage mechanism to be refilled during recall. A single, central capacity limit averaging about four chunks is implicated along with other, noncapacity-limited sources. The pure STM capacity limit expressed in chunks is distinguished from compound STM limits obtained when the number of separately held chunks is unclear. Reasons why pure capacity estimates fall within a narrow range are discussed and a capacity limit for the focus of attention is proposed.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1002/9780470316887", "doi": "10.1002/9780470316887", "title": "Markov Decision Processes", "publicationYear": 1994, "publicationDate": "1994-04-15", "type": "monograph", "publisher": "Wiley", "containerTitle": "Wiley Series in Probability and Statistics", "volume": null, "issue": null, "page": null, "issn": "1940-6347", "isbn": "9780471619772, 9780470316887", "authors": "Martin L. Puterman", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4596, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9780470316887", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9780470316887", "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1145/37402.37406", "doi": "10.1145/37402.37406", "title": "Flocks, herds and schools: A distributed behavioral model", "publicationYear": 1987, "publicationDate": "1987-08", "type": "journal-article", "publisher": "Association for Computing Machinery (ACM)", "containerTitle": "ACM SIGGRAPH Computer Graphics", "volume": "21", "issue": "4", "page": "25-34", "issn": "0097-8930", "isbn": null, "authors": "Craig W. Reynolds", "authorCount": 1, "firstAuthorAffiliation": "Symbolics Graphics Division, Los Angeles, CA", "isReferencedByCount": 4566, "referenceCount": 40, "isOpenAccess": true, "licenseUrl": "https://www.acm.org/publications/policies/copyright_policy#Background", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1145/37402.37406", "pdfUrl": null, "abstract": "The aggregate motion of a flock of birds, a herd of land animals, or a school of fish is a beautiful and familiar part of the natural world. But this type of complex motion is rarely seen in computer animation. This paper explores an approach based on simulation as an alternative to scripting the paths of each bird individually. The simulated flock is an elaboration of a particle systems, with the simulated birds being the particles. The aggregate motion of the simulated flock is created by a distributed behavioral model much like that at work in a natural flock; the birds choose their own course. Each simulated bird is implemented as an independent actor that navigates according to its local perception of the dynamic environment, the laws of simulated physics that rule its motion, and a set of behaviors programmed into it by the \"animator.\" The aggregate motion of the simulated flock is the result of the dense interaction of the relatively simple behaviors of the individual simulated birds.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1016/s0149-7634(00)00014-2", "doi": "10.1016/s0149-7634(00)00014-2", "title": "The adolescent brain and age-related behavioral manifestations", "publicationYear": 2000, "publicationDate": "2000-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Neuroscience &amp; Biobehavioral Reviews", "volume": "24", "issue": "4", "page": "417-463", "issn": "0149-7634", "isbn": null, "authors": "L.P. Spear", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4395, "referenceCount": 611, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0149-7634(00)00014-2", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1001/jama.1992.03480090092034", "doi": "10.1001/jama.1992.03480090092034", "title": "The Concepts of Stress and Stress System Disorders", "publicationYear": 1992, "publicationDate": "1992-03-04", "type": "journal-article", "publisher": "American Medical Association (AMA)", "containerTitle": "JAMA", "volume": "267", "issue": "9", "page": "1244", "issn": "0098-7484", "isbn": null, "authors": "George P. Chrousos", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4258, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1001/jama.1992.03480090092034", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1017/s0140525x12000477", "doi": "10.1017/s0140525x12000477", "title": "Whatever next? Predictive brains, situated agents, and the future of cognitive science", "publicationYear": 2013, "publicationDate": "2013-06", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Behavioral and Brain Sciences", "volume": "36", "issue": "3", "page": "181-204", "issn": "0140-525X, 1469-1825", "isbn": null, "authors": "Andy Clark", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4123, "referenceCount": 214, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/s0140525x12000477", "pdfUrl": null, "abstract": "AbstractBrains, it has recently been argued, are essentially prediction machines. They are bundles of cells that support perception and action by constantly attempting to match incoming sensory inputs with top-down expectations or predictions. This is achieved using a hierarchical generative model that aims to minimize prediction error within a bidirectional cascade of cortical processing. Such accounts offer a unifying model of perception and action, illuminate the functional role of attention, and may neatly capture the special contribution of cortical processing to adaptive success. This target article critically examines this “hierarchical prediction machine” approach, concluding that it offers the best clue yet to the shape of a unified science of mind and action. Sections 1 and 2 lay out the key elements and implications of the approach. Section 3 explores a variety of pitfalls and challenges, spanning the evidential, the methodological, and the more properly conceptual. The paper ends (sections 4 and 5) by asking how such approaches might impact our more general vision of mind, experience, and agency.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.3102/10769986031004437", "doi": "10.3102/10769986031004437", "title": "Computational Tools for Probing Interactions in Multiple Linear Regression, Multilevel Modeling, and Latent Curve Analysis", "publicationYear": 2006, "publicationDate": "2006-12", "type": "journal-article", "publisher": "American Educational Research Association (AERA)", "containerTitle": "Journal of Educational and Behavioral Statistics", "volume": "31", "issue": "4", "page": "437-448", "issn": "1076-9986, 1935-1054", "isbn": null, "authors": "Kristopher J. Preacher, Patrick J. Curran, Daniel J. Bauer", "authorCount": 3, "firstAuthorAffiliation": "University of North Carolina at Chapel Hill", "isReferencedByCount": 4088, "referenceCount": 13, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3102/10769986031004437", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.3102/10769986031004437", "abstract": "Simple slopes, regions of significance, and confidence bands are commonly used to evaluate interactions in multiple linear regression (MLR) models, and the use of these techniques has recently been extended to multilevel or hierarchical linear modeling (HLM) and latent curve analysis (LCA). However, conducting these tests and plotting the conditional relations is often a tedious and error-prone task. This article provides an overview of methods used to probe interaction effects and describes a unified collection of freely available online resources that researchers can use to obtain significance tests for simple slopes, compute regions of significance, and obtain confidence bands for simple slopes across the range of the moderator in the MLR, HLM, and LCA contexts. Plotting capabilities are also provided.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1016/s0022-4359(00)00028-2", "doi": "10.1016/s0022-4359(00)00028-2", "title": "Assessing the effects of quality, value, and customer satisfaction on consumer behavioral intentions in service environments", "publicationYear": 2000, "publicationDate": "2000-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Retailing", "volume": "76", "issue": "2", "page": "193-218", "issn": "0022-4359", "isbn": null, "authors": "J.Joseph Cronin, Michael K Brady, G.Tomas M Hult", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 4087, "referenceCount": 89, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0022-4359(00)00028-2", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.1017/s0140525x00005756", "doi": "10.1017/s0140525x00005756", "title": "Minds, brains, and programs", "publicationYear": 1980, "publicationDate": "1980-09", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Behavioral and Brain Sciences", "volume": "3", "issue": "3", "page": "417-424", "issn": "0140-525X, 1469-1825", "isbn": null, "authors": "John R. Searle", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4037, "referenceCount": 86, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/s0140525x00005756", "pdfUrl": null, "abstract": "AbstractThis article can be viewed as an attempt to explore the consequences of two propositions. (1) Intentionality in human beings (and animals) is a product of causal features of the brain. I assume this is an empirical fact about the actual causal relations between mental processes and brains. It says simply that certain brain processes are sufficient for intentionality. (2) Instantiating a computer program is never by itself a sufficient condition of intentionality. The main argument of this paper is directed at establishing this claim. The form of the argument is to show how a human agent could instantiate the program and still not have the relevant intentionality. These two propositions have the following consequences: (3) The explanation of how the brain produces intentionality cannot be that it does it by instantiating a computer program. This is a strict logical consequence of 1 and 2. (4) Any mechanism capable of producing intentionality must have causal powers equal to those of the brain. This is meant to be a trivial consequence of 1. (5) Any attempt literally to create intentionality artificially (strong AI) could not succeed just by designing programs but would have to duplicate the causal powers of the human brain. This follows from 2 and 4.“Could a machine think?” On the argument advanced here only a machine could think, and only very special kinds of machines, namely brains and machines with internal causal powers equivalent to those of brains. And that is why strong AI has little to tell us about thinking, since it is not about machines but about programs, and no program by itself is sufficient for thinking.", "subject": null, "language": "en", "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.2307/258069", "doi": "10.2307/258069", "title": "Toward a Behavioral Theory of Charismatic Leadership in Organizational Settings", "publicationYear": 1987, "publicationDate": "1987-10", "type": "journal-article", "publisher": "Academy of Management", "containerTitle": "The Academy of Management Review", "volume": "12", "issue": "4", "page": "637", "issn": "0363-7425", "isbn": null, "authors": "Jay A. Conger, Rabindra N. Kanungo", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 4003, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/258069", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mpWYfYgBA5IkaUt39", "_dataset_id": "hjr0ffFzF18NHHhX9"}
{"paperId": "10.3389/fgeed.2022.937853", "doi": "10.3389/fgeed.2022.937853", "title": "Natural and artificial sources of genetic variation used in crop breeding: A baseline comparator for genome editing", "publicationYear": 2022, "publicationDate": "2022-08-22", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Genome Editing", "volume": "4", "issue": null, "page": null, "issn": "2673-3439", "isbn": null, "authors": "Jorge Martínez-Fortún, Dylan W. Phillips, Huw D. Jones", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 26, "referenceCount": 242, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Biotechnology and Biological Sciences Research Council", "funderIds": "10.13039/501100000268", "url": "https://doi.org/10.3389/fgeed.2022.937853", "pdfUrl": null, "abstract": "Traditional breeding has successfully selected beneficial traits for food, feed, and fibre crops over the last several thousand years. The last century has seen significant technological advancements particularly in marker assisted selection and the generation of induced genetic variation, including over the last few decades, through mutation breeding, genetic modification, and genome editing. While regulatory frameworks for traditional varietal development and for genetic modification with transgenes are broadly established, those for genome editing are lacking or are still evolving in many regions. In particular, the lack of “foreign” recombinant DNA in genome edited plants and that the resulting SNPs or INDELs are indistinguishable from those seen in traditional breeding has challenged development of new legislation. Where products of genome editing and other novel breeding technologies possess no transgenes and could have been generated via traditional methods, we argue that it is logical and proportionate to apply equivalent legislative oversight that already exists for traditional breeding and novel foods. This review analyses the types and the scale of spontaneous and induced genetic variation that can be selected during traditional plant breeding activities. It provides a base line from which to judge whether genetic changes brought about by techniques of genome editing or other reverse genetic methods are indeed comparable to those routinely found using traditional methods of plant breeding.", "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.3389/fgeed.2023.1289416", "doi": "10.3389/fgeed.2023.1289416", "title": "CRISPR gene editing to improve crop resistance to parasitic plants", "publicationYear": 2023, "publicationDate": "2023-10-25", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Genome Editing", "volume": "5", "issue": null, "page": null, "issn": "2673-3439", "isbn": null, "authors": "Min-Yao Jhu, Evan E. Ellison, Neelima R. Sinha", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 16, "referenceCount": 89, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Bill and Melinda Gates Foundation, National Science Foundation, California Tomato Research Institute", "funderIds": "10.13039/100000865, 10.13039/100000001, 10.13039/100017813", "url": "https://doi.org/10.3389/fgeed.2023.1289416", "pdfUrl": null, "abstract": "Parasitic plants pose a significant threat to global agriculture, causing substantial crop losses and hampering food security. In recent years, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene-editing technology has emerged as a promising tool for developing resistance against various plant pathogens. Its application in combating parasitic plants, however, remains largely unexplored. This review aims to summarise current knowledge and research gaps in utilising CRISPR to develop resistance against parasitic plants. First, we outline recent improvements in CRISPR gene editing tools, and what has been used to combat various plant pathogens. To realise the immense potential of CRISPR, a greater understanding of the genetic basis underlying parasitic plant-host interactions is critical to identify suitable target genes for modification. Therefore, we discuss the intricate interactions between parasitic plants and their hosts, highlighting essential genes and molecular mechanisms involved in defence response and multilayer resistance. These include host resistance responses directly repressing parasitic plant germination or growth and indirectly influencing parasitic plant development via manipulating environmental factors. Finally, we evaluate CRISPR-mediated effectiveness and long-term implications for host resistance and crop improvement, including inducible resistance response and tissue-specific activity. In conclusion, this review highlights the challenges and opportunities CRISPR technology provides to combat parasitic plants and provides insights for future research directions to safeguard global agricultural productivity.", "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2021.100002", "doi": "10.1016/j.ggedit.2021.100002", "title": "A short, idiosyncratic history of genome editing", "publicationYear": 2021, "publicationDate": "2021-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "1", "issue": null, "page": "100002", "issn": "2666-3880", "isbn": null, "authors": "Dana Carroll", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 64, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.ggedit.2021.100002", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1186/s13059-018-1586-y", "doi": "10.1186/s13059-018-1586-y", "title": "Applications and potential of genome editing in crop improvement", "publicationYear": 2018, "publicationDate": "2018-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Genome Biology", "volume": "19", "issue": "1", "page": null, "issn": "1474-760X", "isbn": null, "authors": "Yi Zhang, Karen Massel, Ian D. Godwin, Caixia Gao", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 392, "referenceCount": 117, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Natural Science Foundation of China, Natural Science Foundation of Shandong Province", "funderIds": "10.13039/501100001809, 10.13039/501100007129", "url": "https://doi.org/10.1186/s13059-018-1586-y", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s13059-018-1586-y.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2022.100024", "doi": "10.1016/j.ggedit.2022.100024", "title": "GEM: Genome Editing Meta-database, a dataset of genome editing related metadata systematically extracted from PubMed literatures", "publicationYear": 2023, "publicationDate": "2023-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "5", "issue": null, "page": "100024", "issn": "2666-3880", "isbn": null, "authors": "Takayuki Suzuki, Hidemasa Bono", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Research Organization of Information and Systems, Japan Science and Technology Agency", "funderIds": "10.13039/100013328, 10.13039/501100002241", "url": "https://doi.org/10.1016/j.ggedit.2022.100024", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.cj.2017.09.009", "doi": "10.1016/j.cj.2017.09.009", "title": "Wheat genome editing expedited by efficient transformation techniques: Progress and perspectives", "publicationYear": 2018, "publicationDate": "2018-02", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "The Crop Journal", "volume": "6", "issue": "1", "page": "22-31", "issn": "2214-5141", "isbn": null, "authors": "Ke Wang, Bisma Riaz, Xingguo Ye", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 39, "referenceCount": 95, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Natural Science Foundation of Beijing Municipality", "funderIds": "10.13039/501100004826", "url": "https://doi.org/10.1016/j.cj.2017.09.009", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2021.100007", "doi": "10.1016/j.ggedit.2021.100007", "title": "TALE and TALEN genome editing technologies", "publicationYear": 2021, "publicationDate": "2021-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "2", "issue": null, "page": "100007", "issn": "2666-3880", "isbn": null, "authors": "Sebastian Becker, Jens Boch", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 145, "referenceCount": 225, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "BMBF Berlin, Bundesministerium für Bildung und Forschung", "funderIds": "10.13039/501100004937, 10.13039/501100002347", "url": "https://doi.org/10.1016/j.ggedit.2021.100007", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2022.100022", "doi": "10.1016/j.ggedit.2022.100022", "title": "Facilitating genome function understanding using genome editing dependent bioimaging techniques", "publicationYear": 2023, "publicationDate": "2023-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "5", "issue": null, "page": "100022", "issn": "2666-3880", "isbn": null, "authors": "Hiroshi Ochiai", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Government of Japan Ministry of Education Culture Sports Science and Technology, JST", "funderIds": "10.13039/501100001700, 10.13039/501100002241", "url": "https://doi.org/10.1016/j.ggedit.2022.100022", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2021.100006", "doi": "10.1016/j.ggedit.2021.100006", "title": "Assignment of responsibility for creating persons using germline genome-editing", "publicationYear": 2021, "publicationDate": "2021-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "1", "issue": null, "page": "100006", "issn": "2666-3880", "isbn": null, "authors": "Tetsuya Ishii", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 47, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Japan Society for the Promotion of Science", "funderIds": "10.13039/501100001691", "url": "https://doi.org/10.1016/j.ggedit.2021.100006", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.15252/embr.202050680", "doi": "10.15252/embr.202050680", "title": "The evolving landscape around genome editing in agriculture", "publicationYear": 2020, "publicationDate": "2020-06-04", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "The EMBO Reports", "volume": "21", "issue": "6", "page": null, "issn": "1469-221X, 1469-3178", "isbn": null, "authors": "Sarah M Schmidt, Melinda Belisle, Wolf B Frommer", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 169, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Alexander von Humboldt Professorship, Bill and Melinda Gates Foundation", "funderIds": "10.13039/100000865", "url": "https://doi.org/10.15252/embr.202050680", "pdfUrl": "https://link.springer.com/content/pdf/10.15252/embr.202050680.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2021.100010", "doi": "10.1016/j.ggedit.2021.100010", "title": "Genome editing of therapeutic T cells", "publicationYear": 2021, "publicationDate": "2021-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "2", "issue": null, "page": "100010", "issn": "2666-3880", "isbn": null, "authors": "Waseem Qasim", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Medical Research Council, National Institute for Health Research, Wellcome Trust, Blood Cancer UK", "funderIds": "10.13039/501100000265, 10.13039/501100000272, 10.13039/100010269, 10.13039/501100015570", "url": "https://doi.org/10.1016/j.ggedit.2021.100010", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2022.100018", "doi": "10.1016/j.ggedit.2022.100018", "title": "Genome editing and bioinformatics", "publicationYear": 2022, "publicationDate": "2022-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "3-4", "issue": null, "page": "100018", "issn": "2666-3880", "isbn": null, "authors": "Kazuki Nakamae, Hidemasa Bono", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 13, "referenceCount": 259, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Japan Society for the Promotion of Science, Japan Science and Technology Agency", "funderIds": "10.13039/501100001691, 10.13039/501100002241", "url": "https://doi.org/10.1016/j.ggedit.2022.100018", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2022.100021", "doi": "10.1016/j.ggedit.2022.100021", "title": "Understanding RNA editing and its use in gene editing", "publicationYear": 2022, "publicationDate": "2022-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "3-4", "issue": null, "page": "100021", "issn": "2666-3880", "isbn": null, "authors": "Ruchika, Takahiro Nakamura", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 65, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Japan Society for the Promotion of Science, JST", "funderIds": "10.13039/501100000646, 10.13039/501100002241", "url": "https://doi.org/10.1016/j.ggedit.2022.100021", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1007/s11248-025-00432-1", "doi": "10.1007/s11248-025-00432-1", "title": "Genome editing research initiatives and regulatory landscape of genome edited crops in India", "publicationYear": 2025, "publicationDate": "2025-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Transgenic Research", "volume": "34", "issue": "1", "page": null, "issn": "0962-8819, 1573-9368", "isbn": null, "authors": "Neha Sharma, Kanika Thakur, Rasna Zinta, Vikas Mangal, Dalamu, Jagesh Kumar Tiwari, Salej Sood, Som Dutt, Vinod Kumar, Brajesh Singh, Ajay Kumar Thakur", "authorCount": 11, "firstAuthorAffiliation": null, "isReferencedByCount": 16, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": "Indian Council of Agricultural Research, Indian Council of Agricultural Research, Indian Council of Agricultural Research, Indian Council of Agricultural Research, Indian Council of Agricultural Research, Indian Council of Agricultural Research, Indian Council of Agricultural Research, Indian Council of Agricultural Research, Indian Council of Agricultural Research, Indian Council of Agricultural Research, Indian Council of Agricultural Research", "funderIds": "10.13039/501100001503, 10.13039/501100001503, 10.13039/501100001503, 10.13039/501100001503, 10.13039/501100001503, 10.13039/501100001503, 10.13039/501100001503, 10.13039/501100001503, 10.13039/501100001503, 10.13039/501100001503, 10.13039/501100001503", "url": "https://doi.org/10.1007/s11248-025-00432-1", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s11248-025-00432-1.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2022.100015", "doi": "10.1016/j.ggedit.2022.100015", "title": "Genome editing in chickens", "publicationYear": 2022, "publicationDate": "2022-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "3-4", "issue": null, "page": "100015", "issn": "2666-3880", "isbn": null, "authors": "Kennosuke Ichikawa, Mei Matsuzaki, Ryo Ezaki, Hiroyuki Horiuchi", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 75, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Japan Society for the Promotion of Science, JST COI, Kieikai Research Foundation", "funderIds": "10.13039/501100001691, 10.13039/501100009033, 10.13039/501100012014", "url": "https://doi.org/10.1016/j.ggedit.2022.100015", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1007/s10343-026-01328-8", "doi": "10.1007/s10343-026-01328-8", "title": "CRISPR/Cas9 Genome Editing in Rice (Oryza sativa L.) for Multi-Stress Resilience and Prospects for Agricultural Sustainability", "publicationYear": 2026, "publicationDate": "2026-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Journal of Crop Health", "volume": "78", "issue": "3", "page": null, "issn": "2948-264X, 2948-2658", "isbn": null, "authors": "Abdul Malik, Nur Ardiyana Rejab, Muhamad Afiq Aziz", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 232, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": "Universiti Malaya", "funderIds": "10.13039/501100004386", "url": "https://doi.org/10.1007/s10343-026-01328-8", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s10343-026-01328-8.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ocsci.2020.03.001", "doi": "10.1016/j.ocsci.2020.03.001", "title": "Genome editing technology and application in soybean improvement", "publicationYear": 2020, "publicationDate": "2020-03", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Oil Crop Science", "volume": "5", "issue": "1", "page": "31-40", "issn": "2096-2428", "isbn": null, "authors": "Aili Bao, Chanjuan Zhang, Yi Huang, Haifeng Chen, Xinan Zhou, Dong Cao", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 59, "referenceCount": 136, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Genetically Modified Organisms Breeding Major Projects", "funderIds": null, "url": "https://doi.org/10.1016/j.ocsci.2020.03.001", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2023.100027", "doi": "10.1016/j.ggedit.2023.100027", "title": "Genome editing for biodiesel production in oleaginous microalga, Nannochloropsis species", "publicationYear": 2023, "publicationDate": "2023-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "6", "issue": null, "page": "100027", "issn": "2666-3880", "isbn": null, "authors": "Tomokazu Kurita, Masako Iwai, Hiroyuki Ohta, Tetsushi Sakuma, Takashi Yamamoto", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 14, "referenceCount": 100, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Co-creation place formation support program, JST", "funderIds": "10.13039/501100020953, 10.13039/501100002241", "url": "https://doi.org/10.1016/j.ggedit.2023.100027", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2021.100005", "doi": "10.1016/j.ggedit.2021.100005", "title": "Base editors: Expanding the types of DNA damage products harnessed for genome editing", "publicationYear": 2021, "publicationDate": "2021-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "1", "issue": null, "page": "100005", "issn": "2666-3880", "isbn": null, "authors": "Sifeng Gu, Zsolt Bodai, Quinn T. Cowan, Alexis C. Komor", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 39, "referenceCount": 116, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institute of General Medical Sciences", "funderIds": "10.13039/100000057", "url": "https://doi.org/10.1016/j.ggedit.2021.100005", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1007/s11101-021-09749-1", "doi": "10.1007/s11101-021-09749-1", "title": "Advanced genome editing strategies for manipulation of plant specialized metabolites pertaining to biofortification", "publicationYear": 2022, "publicationDate": "2022-02", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Phytochemistry Reviews", "volume": "21", "issue": "1", "page": "81-99", "issn": "1568-7767, 1572-980X", "isbn": null, "authors": "Sweta Bhambhani, Kirtikumar R. Kondhare, Ashok P. Giri", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 13, "referenceCount": 129, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": "Council of Scientific and Industrial Research, India, Council of Scientific and Industrial Research (CSIR), India, Department of Science and Technology (DST) - Inspire Faculty program", "funderIds": "10.13039/501100001412", "url": "https://doi.org/10.1007/s11101-021-09749-1", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s11101-021-09749-1.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ocsci.2021.07.002", "doi": "10.1016/j.ocsci.2021.07.002", "title": "CRISPR-based genome editing technology and its applications in oil crops", "publicationYear": 2021, "publicationDate": "2021-07", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Oil Crop Science", "volume": "6", "issue": "3", "page": "105-113", "issn": "2096-2428", "isbn": null, "authors": "Jianjie He, Kai Zhang, Mi Tang, Weixian Zhou, Liurong Chen, Zhaobo Chen, Maoteng Li", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 23, "referenceCount": 164, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Natural Science Foundation of China", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.1016/j.ocsci.2021.07.002", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1007/s13562-026-01079-7", "doi": "10.1007/s13562-026-01079-7", "title": "Advancements in genome editing tools and technologies for improvement of horticultural crops", "publicationYear": 2026, "publicationDate": "2026-06-15", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Journal of Plant Biochemistry and Biotechnology", "volume": null, "issue": null, "page": null, "issn": "0971-7811, 0974-1275", "isbn": null, "authors": "Kasireddy Sivasanakarreddy, Vikramaditya Pandey, Sudhakar Pandey, Sanjay Kumar Singh, Basavaprabhu L. Patil", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 192, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": "Indian Council of Agricultural Research, Indian Council of Agricultural Research", "funderIds": "10.13039/501100001503, 10.13039/501100001503", "url": "https://doi.org/10.1007/s13562-026-01079-7", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s13562-026-01079-7.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.cj.2023.01.001", "doi": "10.1016/j.cj.2023.01.001", "title": "Multiplex genome editing targeting soybean with ultra-low anti-nutritive oligosaccharides", "publicationYear": 2023, "publicationDate": "2023-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "The Crop Journal", "volume": "11", "issue": "3", "page": "825-831", "issn": "2214-5141", "isbn": null, "authors": "Wenxin Lin, Huaqin Kuang, Mengyan Bai, Xiaomeng Jiang, Pengfei Zhou, Yinghua Li, Bo Chen, Huarong Li, Yuefeng Guan", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 15, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Fujian Agriculture and Forestry University", "funderIds": "10.13039/501100008766", "url": "https://doi.org/10.1016/j.cj.2023.01.001", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.3389/fgeed.2022.875243", "doi": "10.3389/fgeed.2022.875243", "title": "Potential of Genome Editing to Capture Diversity From Australian Wild Rice Relatives", "publicationYear": 2022, "publicationDate": "2022-04-27", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Genome Editing", "volume": "4", "issue": null, "page": null, "issn": "2673-3439", "isbn": null, "authors": "Muhammad Abdullah, Pauline Okemo, Agnelo Furtado, Robert Henry", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 104, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "University of Queensland", "funderIds": "10.13039/501100001794", "url": "https://doi.org/10.3389/fgeed.2022.875243", "pdfUrl": null, "abstract": "Rice, a staple food worldwide and a model crop, could benefit from the introduction of novel genetics from wild relatives. Wild rice in the AA genome group closely related to domesticated rice is found across the tropical world. Due to their locality outside the range of domesticated rice, Australian wild rice populations are a potential source of unique traits for rice breeding. These rice species provide a diverse gene pool for improvement that could be utilized for desirable traits such as stress resistance, disease tolerance, and nutritional qualities. However, they remain poorly characterized. The CRISPR/Cas system has revolutionized gene editing and has improved our understanding of gene functions. Coupled with the increasing availability of genomic information on the species, genes in Australian wild rice could be modified through genome editing technologies to produce new domesticates. Alternatively, beneficial alleles from these rice species could be incorporated into cultivated rice to improve critical traits. Here, we summarize the beneficial traits in Australian wild rice, the available genomic information and the potential of gene editing to discover and understand the functions of novel alleles. Moreover, we discuss the potential domestication of these wild rice species for health and economic benefits to rice production globally.", "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.3389/fgeed.2020.571239", "doi": "10.3389/fgeed.2020.571239", "title": "β-Hemoglobinopathies: The Test Bench for Genome Editing-Based Therapeutic Strategies", "publicationYear": 2020, "publicationDate": "2020-12-03", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Genome Editing", "volume": "2", "issue": null, "page": null, "issn": "2673-3439", "isbn": null, "authors": "Gloria Barbarani, Agata Łabedz, Antonella Ellena Ronchi", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 97, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "H2020 Marie Sklodowska-Curie Actions", "funderIds": "10.13039/100010665", "url": "https://doi.org/10.3389/fgeed.2020.571239", "pdfUrl": null, "abstract": "Hemoglobin is a tetrameric protein composed of two α and two β chains, each containing a heme group that reversibly binds oxygen. The composition of hemoglobin changes during development in order to fulfill the need of the growing organism, stably maintaining a balanced production of α-like and β-like chains in a 1:1 ratio. Adult hemoglobin (HbA) is composed of two α and two β subunits (α2β2 tetramer), whereas fetal hemoglobin (HbF) is composed of two γ and two α subunits (α2γ2 tetramer). Qualitative or quantitative defects in β-globin production cause two of the most common monogenic-inherited disorders: β-thalassemia and sickle cell disease. The high frequency of these diseases and the relative accessibility of hematopoietic stem cells make them an ideal candidate for therapeutic interventions based on genome editing. These strategies move in two directions: the correction of the disease-causing mutation and the reactivation of the expression of HbF in adult cells, in the attempt to recreate the effect of hereditary persistence of fetal hemoglobin (HPFH) natural mutations, which mitigate the severity of β-hemoglobinopathies. Both lines of research rely on the knowledge gained so far on the regulatory mechanisms controlling the differential expression of globin genes during development.", "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2022.100017", "doi": "10.1016/j.ggedit.2022.100017", "title": "From nuclease-based gene knock-in to prime editing – promising technologies of precision gene engineering", "publicationYear": 2022, "publicationDate": "2022-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "3-4", "issue": null, "page": "100017", "issn": "2666-3880", "isbn": null, "authors": "Tetsushi Sakuma", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 88, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Japan Society for the Promotion of Science", "funderIds": "10.13039/501100001691", "url": "https://doi.org/10.1016/j.ggedit.2022.100017", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.cj.2025.12.003", "doi": "10.1016/j.cj.2025.12.003", "title": "Genetic transformation and genome editing in wild soybean (Glycine soja)", "publicationYear": 2026, "publicationDate": "2026-04", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "The Crop Journal", "volume": "14", "issue": "2", "page": "684-689", "issn": "2214-5141", "isbn": null, "authors": "Li Chen, Meng Tang, Weiwei Yao, Wensheng Hou, Yupeng Cai", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Key Research and Development Program of China, National Science and Technology Major Project", "funderIds": "10.13039/501100012166, 10.13039/501100018537", "url": "https://doi.org/10.1016/j.cj.2025.12.003", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.cj.2015.12.002", "doi": "10.1016/j.cj.2015.12.002", "title": "CRISPR/Cas9: A powerful tool for crop genome editing", "publicationYear": 2016, "publicationDate": "2016-04", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "The Crop Journal", "volume": "4", "issue": "2", "page": "75-82", "issn": "2214-5141", "isbn": null, "authors": "Gaoyuan Song, Meiling Jia, Kai Chen, Xingchen Kong, Bushra Khattak, Chuanxiao Xie, Aili Li, Long Mao", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 155, "referenceCount": 75, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Ministry of Agriculture of China, Ministry of Agriculture of China, Agricultural Science and Technology Innovation Program", "funderIds": "10.13039/501100012421", "url": "https://doi.org/10.1016/j.cj.2015.12.002", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2022.100011", "doi": "10.1016/j.ggedit.2022.100011", "title": "Risk assessment in gene therapy and somatic genome-editing: An expert interview study", "publicationYear": 2022, "publicationDate": "2022-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "3-4", "issue": null, "page": "100011", "issn": "2666-3880", "isbn": null, "authors": "Merlin Bittlinger, Dirk Hoffmann, Anna Karolina Sierawska, Marcel Mertz, Axel Schambach, Daniel Strech", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 8, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Bundesministerium für Bildung und Forschung, BMBF Berlin, Deutsche Forschungsgemeinschaft, Medizinischen Hochschule Hannover", "funderIds": "10.13039/501100002347, 10.13039/501100004937, 10.13039/501100001659, 10.13039/501100005624", "url": "https://doi.org/10.1016/j.ggedit.2022.100011", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.3389/fgeed.2024.1380682", "doi": "10.3389/fgeed.2024.1380682", "title": "Genome editing in macroalgae: advances and challenges", "publicationYear": 2024, "publicationDate": "2024-03-06", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Genome Editing", "volume": "6", "issue": null, "page": null, "issn": "2673-3439", "isbn": null, "authors": "Jonas De Saeger, Emma Coulembier Vandelannoote, Hojun Lee, Jihae Park, Jonas Blomme", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 21, "referenceCount": 122, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Fonds Wetenschappelijk Onderzoek, National Research Foundation of Korea", "funderIds": "10.13039/501100003130, 10.13039/501100003725", "url": "https://doi.org/10.3389/fgeed.2024.1380682", "pdfUrl": null, "abstract": "This minireview examines the current state and challenges of genome editing in macroalgae. Despite the ecological and economic significance of this group of organisms, genome editing has seen limited applications. While CRISPR functionality has been established in two brown (Ectocarpus species 7 and Saccharina japonica) and one green seaweed (Ulva prolifera), these studies are limited to proof-of-concept demonstrations. All studies also (co)-targeted ADENINE PHOSPHORIBOSYL TRANSFERASE to enrich for mutants, due to the relatively low editing efficiencies. To advance the field, there should be a focus on advancing auxiliary technologies, particularly stable transformation, so that novel editing reagents can be screened for their efficiency. More work is also needed on understanding DNA repair in these organisms, as this is tightly linked with the editing outcomes. Developing efficient genome editing tools for macroalgae will unlock the ability to characterize their genes, which is largely uncharted terrain. Moreover, given their economic importance, genome editing will also impact breeding campaigns to develop strains that have better yields, produce more commercially valuable compounds, and show improved resilience to the impacts of global change.", "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2022.100013", "doi": "10.1016/j.ggedit.2022.100013", "title": "Genome editing technology and applications with the type I CRISPR system", "publicationYear": 2022, "publicationDate": "2022-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "3-4", "issue": null, "page": "100013", "issn": "2666-3880", "isbn": null, "authors": "Kazuto Yoshimi, Tomoji Mashimo", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 10, "referenceCount": 80, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Japan Society for the Promotion of Science, Japan Society for the Promotion of Science, Japan Society for the Promotion of Science", "funderIds": "10.13039/501100001691, 10.13039/501100001691, 10.13039/501100001691", "url": "https://doi.org/10.1016/j.ggedit.2022.100013", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2022.100023", "doi": "10.1016/j.ggedit.2022.100023", "title": "The methylation inhibitor 3DZNep promotes HDR pathway choice during CRISPR-Cas9 genome editing", "publicationYear": 2023, "publicationDate": "2023-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "5", "issue": null, "page": "100023", "issn": "2666-3880", "isbn": null, "authors": "Nadja Bischoff, Sandra Wimberger, Ralf Kühn, Anne Laugesen, Volkan Turan, Brian Daniel Larsen, Claus Storgaard Sørensen, Kristian Helin, Eric Paul Bennett, Marcello Maresca, Cord Brakebusch", "authorCount": 11, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 28, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "European Union", "funderIds": "10.13039/501100000780", "url": "https://doi.org/10.1016/j.ggedit.2022.100023", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.3389/fgeed.2020.613252", "doi": "10.3389/fgeed.2020.613252", "title": "Gene Editing and Genotoxicity: Targeting the Off-Targets", "publicationYear": 2020, "publicationDate": "2020-12-10", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Genome Editing", "volume": "2", "issue": null, "page": null, "issn": "2673-3439", "isbn": null, "authors": "Georges Blattner, Alessia Cavazza, Adrian J. Thrasher, Giandomenico Turchiano", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 60, "referenceCount": 122, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.3389/fgeed.2020.613252", "pdfUrl": null, "abstract": "Gene editing technologies show great promise for application to human disease as a result of rapid developments in targeting tools notably based on ZFN, TALEN, and CRISPR-Cas systems. Precise modification of a DNA sequence is now possible in mature human somatic cells including stem and progenitor cells with increasing degrees of efficiency. At the same time new technologies are required to evaluate their safety and genotoxicity before widespread clinical application can be confidently implemented. A number of methodologies have now been developed in an attempt to predict expected and unexpected modifications occurring during gene editing. This review surveys the techniques currently available as state of the art, highlighting benefits and limitations, and discusses approaches that may achieve sufficient accuracy and predictability for application in clinical settings.", "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2022.100019", "doi": "10.1016/j.ggedit.2022.100019", "title": "CRISPR-Cas systems in diagnostics: A comprehensive assessment of Cas effectors and biosensors", "publicationYear": 2022, "publicationDate": "2022-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "3-4", "issue": null, "page": "100019", "issn": "2666-3880", "isbn": null, "authors": "Reha Onur Azizoglu", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 72, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "TÜBİTAK", "funderIds": "10.13039/501100004410", "url": "https://doi.org/10.1016/j.ggedit.2022.100019", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.tplants.2025.10.016", "doi": "10.1016/j.tplants.2025.10.016", "title": "Promoter/enhancer replacement by genome editing for crop improvement", "publicationYear": 2026, "publicationDate": "2026-03", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Trends in Plant Science", "volume": "31", "issue": "3", "page": "273-281", "issn": "1360-1385", "isbn": null, "authors": "Takashi Nobusawa, Hiroshi Yamatani, Makoto Kusaba", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 39, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Kato Foundation for Promotion of Science, Naito Foundation", "funderIds": "10.13039/501100004050, 10.13039/100007428", "url": "https://doi.org/10.1016/j.tplants.2025.10.016", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.64898/2026.04.22.720221", "doi": "10.64898/2026.04.22.720221", "title": "Turnip mosaic virus-based gRNA delivery system for plant genome editing", "publicationYear": 2026, "publicationDate": "2026-04-24", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Ekkachai Khwanbua, Ryan R. Lappe, Austin A. Bierl, Steven A. Whitham", "authorCount": 4, "firstAuthorAffiliation": "Department of Plant Pathology, Entomology and Microbiology, Iowa State University, Ames, IA 50011, USA", "isReferencedByCount": 0, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/4.0/", "funderNames": "Iowa State University Plant Sciences Institute, Iowa State University Crop Bioengineering Center", "funderIds": null, "url": "https://doi.org/10.64898/2026.04.22.720221", "pdfUrl": null, "abstract": "Abstract Plant virus-based gRNA delivery systems offer a rapid alternative to stable transformation for CRISPR-mediated genome editing, but potyvirus-based platforms in Cas9-expressing plants are still underexplored. Here, we developed a turnip mosaic virus (TuMV)-based system for gRNA delivery in Cas9-expressing Nicotiana benthamiana and tested whether Csy4-mediated gRNA processing could improve editing efficiency. A TuMV construct carrying a gRNA targeting PHYTOENE DESATURASE ( NbPDS ) induced detectable editing in both infiltrated and systemic tissues, although editing frequencies were low. Incorporation of the bacterial endoribonuclease Csy4 increased editing efficiencies in the two NbPDS genes, raising editing in infiltrated leaves to 7.1–13.8% for NbPDSa and 7.6–23.0% for NbPDSb , while lower but reproducible editing was detectable in systemic leaves. The TuMV-Csy4 platform also supported editing of a second endogenous target, MAGNESIUM CHELATASE SUBUNIT H ( NbChlH ), and enabled multiplex editing of NbPDS and NbChlH regardless of guide order. Editing efficiencies were consistently higher in infiltrated leaves than in systemic leaves, and no visible photobleaching or chlorosis was observed in systemic tissues despite confirmed molecular editing. To assess the potential for heritable editing, a tRNA Ile mobility element was fused to the NbPDS gRNA. Although this construct increased somatic editing, no albino progeny were recovered after screening approximately 20,000 seedlings, indicating that heritable editing was not achieved under these conditions. Together, these results establish TuMV as a platform for Cas9-based gRNA delivery and show that Csy4-mediated processing improves editing efficiency, supports multiplex targeting, and demonstrates the feasibility of potyvirus-based genome editing systems in plants.", "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.xplc.2021.100141", "doi": "10.1016/j.xplc.2021.100141", "title": "Advancing organelle genome transformation and editing for crop improvement", "publicationYear": 2021, "publicationDate": "2021-03", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Plant Communications", "volume": "2", "issue": "2", "page": "100141", "issn": "2590-3462", "isbn": null, "authors": "Shengchun Li, Ling Chang, Jiang Zhang", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 63, "referenceCount": 146, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Natural Science Foundation of China, Science and Technology Department of Hubei Province", "funderIds": "10.13039/501100001809, 10.13039/501100018806", "url": "https://doi.org/10.1016/j.xplc.2021.100141", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.3390/plants11020212", "doi": "10.3390/plants11020212", "title": "Genome Editing in Crop Plant Research—Alignment of Expectations and Current Developments", "publicationYear": 2022, "publicationDate": "2022-01-14", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Plants", "volume": "11", "issue": "2", "page": "212", "issn": "2223-7747", "isbn": null, "authors": "Meike Hüdig, Natalie Laibach, Anke-Christiane Hein", "authorCount": 3, "firstAuthorAffiliation": "Molecular Plant Physiology Division, Institute of Molecular Physiology and Biotechnology of Plants, University of Bonn, Kirschallee 1, 53115 Bonn, Germany", "isReferencedByCount": 16, "referenceCount": 170, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety", "funderIds": "10.13039/501100005910", "url": "https://doi.org/10.3390/plants11020212", "pdfUrl": null, "abstract": "The rapid development of genome editing and other new genomic techniques (NGT) has evoked manifold expectations on purposes of the application of these techniques to crop plants. In this study, we identify and align these expectations with current scientific development. We apply a semi-quantitative text analysis approach on political, economic, and scientific opinion papers to disentangle and extract expectations towards the application of NGT-based plants. Using the sustainable development goals (SDG) of the 2030 agenda as categories, we identify contributions to food security or adaptation to climatic changes as the most frequently mentioned expectations, accompanied by the notion of sustainable agriculture and food systems. We then link SDG with relevant plant traits and review existing research and commercial field trials for genome-edited crop plants. For a detailed analysis we pick as representative traits drought tolerance and resistance against fungal pathogens. Diverse genetic setscrews for both traits have been identified, modified, and tested under laboratory conditions, although there are only a few in the field. All in all, NGT-plants that can withstand more than one stressor or different environments are not documented in advanced development states. We further conclude that developing new plants with modified traits will not be sufficient to reach food security or adaption to climatic changes in a short time frame. Further scientific development of sustainable agricultural systems will need to play an important role to tackle SDG challenges, as well.", "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2021.100008", "doi": "10.1016/j.ggedit.2021.100008", "title": "Moving from in vitro to in vivo CRISPR screens", "publicationYear": 2021, "publicationDate": "2021-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "2", "issue": null, "page": "100008", "issn": "2666-3880", "isbn": null, "authors": "Maria Kuhn, António J. Santinha, Randall J. Platt", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 41, "referenceCount": 115, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "ETH Zurich", "funderIds": "10.13039/501100003006", "url": "https://doi.org/10.1016/j.ggedit.2021.100008", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.3389/fgeed.2023.1138843", "doi": "10.3389/fgeed.2023.1138843", "title": "Genome editing in rice mediated by miniature size Cas nuclease SpCas12f", "publicationYear": 2023, "publicationDate": "2023-03-13", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Genome Editing", "volume": "5", "issue": null, "page": null, "issn": "2673-3439", "isbn": null, "authors": "Satoru Sukegawa, Osamu Nureki, Seiichi Toki, Hiroaki Saika", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 31, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Cabinet Office, Government of Japan, Ministry of Agriculture, Forestry and Fisheries", "funderIds": "10.13039/501100002770, 10.13039/501100003993", "url": "https://doi.org/10.3389/fgeed.2023.1138843", "pdfUrl": null, "abstract": "Cas9 derived from Streptococcus pyogenes (SpCas9) is used widely in genome editing using the CRISPR-Cas system due to its high activity, but is a relatively large molecule (1,368 amino acid (a.a.) residues). Recently, targeted mutagenesis in human cells and maize using Cas12f derived from Syntrophomonas palmitatica (SpCas12f)—a very small Cas of 497 a.a, which is a more suitable size for virus vectors—was reported. However, there are no reports of genome editing using SpCas12f in crops other than maize. In this study, we applied SpCas12f to genome editing in rice—one of the most important staple crops in the world. An expression vector encoding rice codon-optimized SpCas12f and sgRNA for OsTubulin as a target was introduced into rice calli by Agrobacterium-mediated transformation. Molecular analysis of SpCas12f-transformed calli showed that mutations were introduced successfully into the target region. Detailed analysis by amplicon sequencing revealed estimated mutation frequencies (a ratio of the number of mutated calli to that of SpCas12f-transformed calli) of 28.8% and 55.6% in two targets. Most mutation patterns were deletions, but base substitutions and insertions were also confirmed at low frequency. Moreover, off-target mutations by SpCas12f were not found. Furthermore, mutant plants were regenerated successfully from the mutated calli. It was confirmed that the mutations in the regenerated plants were inherited to the next-generation. In the previous report in maize, mutations were introduced by treatment with heat shock at 45°C for 4 h per day for 3 days; no mutations were introduced under normal growth conditions at 28°C. Surprisingly, however, mutations can be introduced without heat-shock treatment in rice. This might be due to the culture conditions, with relatively higher temperature (30°C or higher) and constant light during callus proliferation. Taken together, we demonstrated that SpCas12f can be used to achieve targeted mutagenesis in rice. SpCas12f is thus a useful tool for genome editing in rice and is suitable for virus vector-mediated genome editing due to its very small size.", "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.3389/fgeed.2025.1542487", "doi": "10.3389/fgeed.2025.1542487", "title": "CRISPR-mediated genome editing of wheat for enhancing disease resistance", "publicationYear": 2025, "publicationDate": "2025-02-25", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Genome Editing", "volume": "7", "issue": null, "page": null, "issn": "2673-3439", "isbn": null, "authors": "Joshua Waites, V. Mohan Murali Achary, Easter D. Syombua, Sarah J. Hearne, Anindya Bandyopadhyay", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 23, "referenceCount": 123, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Bill and Melinda Gates Foundation", "funderIds": "10.13039/100000865", "url": "https://doi.org/10.3389/fgeed.2025.1542487", "pdfUrl": null, "abstract": "Wheat is cultivated across diverse global environments, and its productivity is significantly impacted by various biotic stresses, most importantly but not limited to rust diseases, Fusarium head blight, wheat blast, and powdery mildew. The genetic diversity of modern cultivars has been eroded by domestication and selection, increasing their vulnerability to biotic stress due to uniformity. The rapid spread of new highly virulent and aggressive pathogen strains has exacerbated this situation. Three strategies can be used for enhancing disease resistance through genome editing: introducing resistance (R) gene-mediated resistance, engineering nucleotide-binding leucine-rich repeat receptors (NLRs), and manipulating susceptibility (S) genes to stop pathogens from exploiting these factors to support infection. Utilizing R gene-mediated resistance is the most common strategy for traditional breeding approaches, but the continuous evolution of pathogen effectors can eventually overcome this resistance. Moreover, modifying S genes can confer pleiotropic effects that hinder their use in agriculture. Enhancing disease resistance is paramount for sustainable wheat production and food security, and new tools and strategies are of great importance to the research community. The application of CRISPR-based genome editing provides promise to improve disease resistance, allowing access to a broader range of solutions beyond random mutagenesis or intraspecific variation, unlocking new ways to improve crops, and speeding up resistance breeding. Here, we first summarize the major disease resistance strategies in the context of important wheat diseases and their limitations. Next, we turn our attention to the powerful applications of genome editing technology in creating new wheat varieties against important wheat diseases.", "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2022.100012", "doi": "10.1016/j.ggedit.2022.100012", "title": "Epigenome editing in mice: The dawn of the reverse epigenetics era", "publicationYear": 2022, "publicationDate": "2022-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "3-4", "issue": null, "page": "100012", "issn": "2666-3880", "isbn": null, "authors": "Izuho Hatada, Sumiyo Morita, Takuro Horii", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 40, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Ministry of Education, Culture, Sports, Science and Technology, Japan Agency for Medical Research and Development", "funderIds": "10.13039/501100001700, 10.13039/100009619", "url": "https://doi.org/10.1016/j.ggedit.2022.100012", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.3389/fgeed.2023.1068637", "doi": "10.3389/fgeed.2023.1068637", "title": "In search of an ideal template for therapeutic genome editing: A review of current developments for structure optimization", "publicationYear": 2023, "publicationDate": "2023-02-22", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Genome Editing", "volume": "5", "issue": null, "page": null, "issn": "2673-3439", "isbn": null, "authors": "Alena Shakirova, Timofey Karpov, Yaroslava Komarova, Kirill Lepik", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 28, "referenceCount": 174, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Russian Science Support Foundation", "funderIds": "10.13039/100009409", "url": "https://doi.org/10.3389/fgeed.2023.1068637", "pdfUrl": null, "abstract": "Gene therapy is a fast developing field of medicine with hundreds of ongoing early-stage clinical trials and numerous preclinical studies. Genome editing (GE) now is an increasingly important technology for achieving stable therapeutic effect in gene correction, with hematopoietic cells representing a key target cell population for developing novel treatments for a number of hereditary diseases, infections and cancer. By introducing a double strand break (DSB) in the defined locus of genomic DNA, GE tools allow to knockout the desired gene or to knock-in the therapeutic gene if provided with an appropriate repair template. Currently, the efficiency of methods for GE-mediated knock-in is limited. Significant efforts were focused on improving the parameters and interaction of GE nuclease proteins. However, emerging data suggests that optimal characteristics of repair templates may play an important role in the knock-in mechanisms. While viral vectors with notable example of AAVs as a donor template carrier remain the mainstay in many preclinical trials, non-viral templates, including plasmid and linear dsDNA, long ssDNA templates, single and double-stranded ODNs, represent a promising alternative. Furthermore, tuning of editing conditions for the chosen template as well as its structure, length, sequence optimization, homology arm (HA) modifications may have paramount importance for achieving highly efficient knock-in with favorable safety profile. This review outlines the current developments in optimization of templates for the GE mediated therapeutic gene correction.", "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.cj.2022.07.004", "doi": "10.1016/j.cj.2022.07.004", "title": "See the color, see the seed: GmW1 as a visual reporter for transgene and genome editing in soybean", "publicationYear": 2023, "publicationDate": "2023-02", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "The Crop Journal", "volume": "11", "issue": "1", "page": "311-315", "issn": "2214-5141", "isbn": null, "authors": "Li Chen, Shan Yuan, Yupeng Cai, Weiwei Yao, Qiang Su, Yingying Chen, Jialing Zhang, Wensheng Hou", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 13, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "The Agricultural Science and Technology Innovation Program", "funderIds": "10.13039/501100012421", "url": "https://doi.org/10.1016/j.cj.2022.07.004", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1007/s00425-026-05007-w", "doi": "10.1007/s00425-026-05007-w", "title": "CRISP-PTG-Assembler Ver. 1.0: a primer design tool for polycistronic tRNA-gRNA (PTG) assembly for Cas9-based multiplex genome editing in plants", "publicationYear": 2026, "publicationDate": "2026-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Planta", "volume": "263", "issue": "6", "page": null, "issn": "0032-0935, 1432-2048", "isbn": null, "authors": "Soham Ray, Joshitha Vijayan, S. Vanchinathan, Rajkumar Dhakar, Nazima Nasrullah, Shivani Nagar, Tushar Kanti Dutta, Viswanthan Chinnusamy", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 35, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": "Science and Engineering Research Board (SERB), GoI, Indian Council of Agricultural Research, Indian Council of Agricultural Research", "funderIds": "10.13039/501100001503, 10.13039/501100001503", "url": "https://doi.org/10.1007/s00425-026-05007-w", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s00425-026-05007-w.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.3389/fgeed.2020.604876", "doi": "10.3389/fgeed.2020.604876", "title": "Establishment of CRISPR/Cas9 Genome Editing in Witloof (Cichorium intybus var. foliosum)", "publicationYear": 2020, "publicationDate": "2020-12-21", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Genome Editing", "volume": "2", "issue": null, "page": null, "issn": "2673-3439", "isbn": null, "authors": "Charlotte De Bruyn, Tom Ruttink, Tom Eeckhaut, Thomas Jacobs, Ellen De Keyser, Alain Goossens, Katrijn Van Laere", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 33, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Fonds Wetenschappelijk Onderzoek", "funderIds": "10.13039/501100003130", "url": "https://doi.org/10.3389/fgeed.2020.604876", "pdfUrl": null, "abstract": "Cichorium intybus var. foliosum (witloof) is an economically important crop with a high nutritional value thanks to many specialized metabolites, such as polyphenols and terpenoids. However, witloof plants are rich in sesquiterpene lactones (SL) which are important for plant defense but also impart a bitter taste, thus limiting industrial applications. Inactivating specific genes in the SL biosynthesis pathway could lead to changes in the SL metabolite content and result in altered bitterness. In this study, a CRISPR/Cas9 genome editing workflow was implemented for witloof, starting with polyethylene glycol (PEG) mediated protoplast transfection for CRISPR/Cas9 vector delivery, followed by whole plant regeneration and mutation analysis. Protoplast transfection efficiencies ranged from 20 to 26 %. A CRISPR/Cas9 vector targeting the first exon of the phytoene desaturase (CiPDS) gene was transfected into witloof protoplasts and resulted in the knockout of CiPDS, giving rise to an albino phenotype in 23% of the regenerated plants. Further implementing our protocol, the SL biosynthesis pathway genes germacrene A synthase (GAS), germacrene A oxidase (GAO), and costunolide synthase (COS) were targeted in independent experiments. Highly multiplex (HiPlex) amplicon sequencing of the genomic target loci revealed plant mutation frequencies of 27.3, 42.7, and 98.3% in regenerated plants transfected with a CRISPR/Cas9 vector targeting CiGAS, CiGAO, and CiCOS, respectively. We observed different mutation spectra across the loci, ranging from consistently the same +1 nucleotide insertion in CiCOS across independent mutated lines, to a complex set of 20 mutation types in CiGAO across independent mutated lines. These results demonstrate a straightforward workflow for genome editing based on transfection and regeneration of witloof protoplasts and subsequent HiPlex amplicon sequencing. Our CRISPR/Cas9 workflow can enable gene functional research and faster incorporation of novel traits in elite witloof lines in the future, thus facilitating the development of novel industrial applications for witloof.", "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1016/j.ggedit.2024.100033", "doi": "10.1016/j.ggedit.2024.100033", "title": "On the edge of deletion: Using natural and engineered microhomology to edit the human genome", "publicationYear": 2024, "publicationDate": "2024-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene and Genome Editing", "volume": "7", "issue": null, "page": "100033", "issn": "2666-3880", "isbn": null, "authors": "Gabriel Martínez-Gálvez, Suji Lee, Ryo Niwa, Knut Woltjen", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 69, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Japan Agency for Medical Research and Development", "funderIds": "10.13039/100009619", "url": "https://doi.org/10.1016/j.ggedit.2024.100033", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.3389/fgeed.2023.1247702", "doi": "10.3389/fgeed.2023.1247702", "title": "Cytosine base editors optimized for genome editing in potato protoplasts", "publicationYear": 2023, "publicationDate": "2023-08-30", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Genome Editing", "volume": "5", "issue": null, "page": null, "issn": "2673-3439", "isbn": null, "authors": "Ida Westberg, Frida Meijer Carlsen, Ida Elisabeth Johansen, Bent Larsen Petersen", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Novo Nordisk Fonden, Danmarks Frie Forskningsfond, Grønt Udviklings-og Demonstrations Program", "funderIds": "10.13039/501100009708, 10.13039/501100011958, 10.13039/501100022592", "url": "https://doi.org/10.3389/fgeed.2023.1247702", "pdfUrl": null, "abstract": "In this study, we generated and compared three cytidine base editors (CBEs) tailor-made for potato (Solanum tuberosum), which conferred up to 43% C-to-T conversion of all alleles in the protoplast pool. Earlier, gene-edited potato plants were successfully generated by polyethylene glycol-mediated CRISPR/Cas9 transformation of protoplasts followed by explant regeneration. In one study, a 3–4-fold increase in editing efficiency was obtained by replacing the standard Arabidopsis thaliana AtU6-1 promotor with endogenous potato StU6 promotors driving the expression of the gRNA. Here, we used this optimized construct (SpCas9/StU6-1::gRNA1, target gRNA sequence GGTC4C5TTGGAGC12AAAAC17TGG) for the generation of CBEs tailor-made for potato and tested for C-to-T base editing in the granule-bound starch synthase 1 gene in the cultivar Desiree. First, the Streptococcus pyogenes Cas9 was converted into a (D10A) nickase (nCas9). Next, one of three cytosine deaminases from human hAPOBEC3A (A3A), rat (evo_rAPOBEC1) (rA1), or sea lamprey (evo_PmCDA1) (CDA1) was C-terminally fused to nCas9 and a uracil-DNA glycosylase inhibitor, with each module interspaced with flexible linkers. The CBEs were overall highly efficient, with A3A having the best overall base editing activity, with an average 34.5%, 34.5%, and 27% C-to-T conversion at C4, C5, and C12, respectively, whereas CDA1 showed an average base editing activity of 34.5%, 34%, and 14.25% C-to-T conversion at C4, C5, and C12, respectively. rA1 exhibited an average base editing activity of 18.75% and 19% at C4 and C5 and was the only base editor to show no C-to-T conversion at C12.", "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1186/s13059-017-1324-x", "doi": "10.1186/s13059-017-1324-x", "title": "Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome", "publicationYear": 2017, "publicationDate": "2017-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Genome Biology", "volume": "18", "issue": "1", "page": null, "issn": "1474-760X", "isbn": null, "authors": "Chammiran Daniel, Albin Widmark, Ditte Rigardt, Marie Öhman", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 39, "referenceCount": 54, "isOpenAccess": true, "licenseUrl": null, "funderNames": "Vetenskapsrådet", "funderIds": "10.13039/501100004359", "url": "https://doi.org/10.1186/s13059-017-1324-x", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s13059-017-1324-x.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.35802/208189", "doi": "10.35802/208189", "title": null, "publicationYear": 2017, "publicationDate": "2017-09-01", "type": "grant", "publisher": "Wellcome", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.35802/208189", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "sRQXmOoiUjxjBPJca", "_dataset_id": "r4fQY6S49ihIXTtEH"}
{"paperId": "10.1787/888932341176", "doi": "10.1787/888932341176", "title": "1.3. Monetary policy, inflation and exchange rate", "publicationYear": 2010, "publicationDate": "2010-10-11", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/888932341176", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.12120", "doi": "10.1257/rct.12120", "title": "Monetary policy and households macroeconomic expectations", "publicationYear": 2023, "publicationDate": "2023-09-15", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Timo Wochner, Niklas Potrafke, Klaus Gründler, Michael Lamla", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.12120", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.17868-1.0", "doi": "10.1257/rct.17868-1.0", "title": "Survey on understanding and expectations of monetary policy", "publicationYear": 2026, "publicationDate": "2026-02-10", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Aina Puig, Xuguang Sheng", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.17868-1.0", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/888932341366", "doi": "10.1787/888932341366", "title": "1.13. Inflation and monetary policy target range", "publicationYear": 2010, "publicationDate": "2010-10-11", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/888932341366", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.17868", "doi": "10.1257/rct.17868", "title": "Survey on understanding and expectations of monetary policy", "publicationYear": 2026, "publicationDate": "2026-02-10", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Aina Puig, Xuguang Sheng", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.17868", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.12120-1.0", "doi": "10.1257/rct.12120-1.0", "title": "Monetary policy and households macroeconomic expectations", "publicationYear": 2023, "publicationDate": "2023-09-15", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Timo Wochner, Niklas Potrafke, Klaus Gründler, Michael Lamla", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.12120-1.0", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/000282802320189104", "doi": "10.1257/000282802320189104", "title": "Monetary-Policy Rules and the Great Inflation", "publicationYear": 2002, "publicationDate": "2002-04-01", "type": "journal-article", "publisher": "American Economic Association", "containerTitle": "American Economic Review", "volume": "92", "issue": "2", "page": "115-120", "issn": "0002-8282", "isbn": null, "authors": "Athanasios Orphanides", "authorCount": 1, "firstAuthorAffiliation": "Board of Governors of the Federal Reserve System, 20th and C Streets, N.W., Washington, DC 20551.", "isReferencedByCount": 180, "referenceCount": 5, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/000282802320189104", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.8592-2.0", "doi": "10.1257/rct.8592-2.0", "title": "The ECB's 2021 Monetary Policy Reform in the Eyes of the German Population", "publicationYear": 2021, "publicationDate": "2021-11-19", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Bernd Hayo", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.8592-2.0", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/652052036605", "doi": "10.1787/652052036605", "title": "1.7. Inflation, exchange rate and monetary policy, 1999-2009", "publicationYear": 2009, "publicationDate": "2009-06-25", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/652052036605", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/414731445773", "doi": "10.1787/414731445773", "title": "1.6. Inflation, monetary policy and exchange rates, 2000‑08", "publicationYear": 2008, "publicationDate": "2008-09-30", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/414731445773", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.8592-1.2000000000000003", "doi": "10.1257/rct.8592-1.2000000000000003", "title": "The ECB's 2021 Monetary Policy Reform in the Eyes of the German Population", "publicationYear": 2021, "publicationDate": "2021-11-19", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Bernd Hayo", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.8592-1.2000000000000003", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.8592-1.2000000000000002", "doi": "10.1257/rct.8592-1.2000000000000002", "title": "The ECB's 2021 Monetary Policy Reform in the Eyes of the German Population", "publicationYear": 2021, "publicationDate": "2021-11-19", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Bernd Hayo", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.8592-1.2000000000000002", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.8592", "doi": "10.1257/rct.8592", "title": "The ECB's 2021 Monetary Policy Reform in the Eyes of the German Population", "publicationYear": 2021, "publicationDate": "2021-11-19", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Bernd Hayo", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.8592", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.8592-1.0", "doi": "10.1257/rct.8592-1.0", "title": "The ECB's 2021 Monetary Policy Reform in the Eyes of the German Population", "publicationYear": 2021, "publicationDate": "2021-11-19", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Bernd Hayo", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.8592-1.0", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.8592-1.1", "doi": "10.1257/rct.8592-1.1", "title": "The ECB's 2021 Monetary Policy Reform in the Eyes of the German Population", "publicationYear": 2021, "publicationDate": "2021-11-19", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Bernd Hayo", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.8592-1.1", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.16439", "doi": "10.1257/rct.16439", "title": "Revisiting the Monetary Policy Response to the 2021-2022 Inflation Surge: Households' Assessment and Inflation Expectations", "publicationYear": 2025, "publicationDate": "2025-08-01", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Annabell Schneider", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.16439", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.16439-1.0", "doi": "10.1257/rct.16439-1.0", "title": "Revisiting the Monetary Policy Response to the 2021-2022 Inflation Surge: Households' Assessment and Inflation Expectations", "publicationYear": 2025, "publicationDate": "2025-08-01", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Annabell Schneider", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.16439-1.0", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/jep.2.3.73", "doi": "10.1257/jep.2.3.73", "title": "Monetary Policy Lessons of Recent Inflation and Disinflation", "publicationYear": 1988, "publicationDate": "1988-08-01", "type": "journal-article", "publisher": "American Economic Association", "containerTitle": "Journal of Economic Perspectives", "volume": "2", "issue": "3", "page": "73-100", "issn": "0895-3309", "isbn": null, "authors": "William Poole", "authorCount": 1, "firstAuthorAffiliation": "Professor of Economics, Brown University, Providence, Rhode Island.", "isReferencedByCount": 58, "referenceCount": 17, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/jep.2.3.73", "pdfUrl": null, "abstract": "I will consider the monetary policy lessons of the recent inflation and disinflation. The next section of this paper is devoted to the decline of M1 velocity after 1981 and the demise of the “standard” money demand function. Some authors conclude that this evidence leaves us so uncertain about the nature of money demand that policymakers cannot rely at all on any presumed money demand regularities. In contrast, my working hypothesis is that the money demand continues to be a stable function of relatively few variables, but that the interest elasticity of money demand is substantially higher than previously thought. Events have not been kind to Keynesian monetary policy positions either. Keynesians tend to concentrate on interest rates -- especially real interest rates -- as the best guide to the effects of monetary policy on the economy. The real rate is discussed in the third section of the paper. The fourth section is devoted to an analysis of the importance of market expectations about monetary policy, with a particular focus on how market expectations were influenced by the Federal Reserve's introduction of new monetary control procedures in October 1979. The fifth section of the paper contains an evaluation of the contribution of monetary policy to the disinflation of the 1980s. In the sixth and final section, I conclude with some comments on the implications of the previous sections for the debate on monetary rules.", "subject": null, "language": "en", "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.12145-1.0", "doi": "10.1257/rct.12145-1.0", "title": "Inflation Literacy, Inflation Expectations, and Trust in the Central Bank: A Survey Experiment", "publicationYear": 2023, "publicationDate": "2023-09-19", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Giang Nghiem, Lena Dräger", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.12145-1.0", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/652280580731", "doi": "10.1787/652280580731", "title": "2.7. Inflation, exchange rate and monetary policy responses: An event analysis", "publicationYear": 2009, "publicationDate": "2009-06-25", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/652280580731", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/888933221117", "doi": "10.1787/888933221117", "title": "Inflation and monetary policy: Israel", "publicationYear": 2015, "publicationDate": "2015-06-02", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/888933221117", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.12145", "doi": "10.1257/rct.12145", "title": "Inflation Literacy, Inflation Expectations, and Trust in the Central Bank: A Survey Experiment", "publicationYear": 2023, "publicationDate": "2023-09-19", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Giang Nghiem, Lena Dräger", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.12145", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/888932609190", "doi": "10.1787/888932609190", "title": "Inflation and monetary policy: India", "publicationYear": 2012, "publicationDate": "2012-05-21", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/888932609190", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.10620", "doi": "10.1257/rct.10620", "title": "Monetary policy and macroeconomic expectations", "publicationYear": 2022, "publicationDate": "2022-12-10", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Niklas Potrafke, Klaus Gründler, Michael Lamla, Timo Wochner", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.10620", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.10620-1.0", "doi": "10.1257/rct.10620-1.0", "title": "Monetary policy and macroeconomic expectations", "publicationYear": 2022, "publicationDate": "2022-12-10", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Niklas Potrafke, Klaus Gründler, Michael Lamla, Timo Wochner", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.10620-1.0", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.3386/w0203", "doi": "10.3386/w0203", "title": "Taxation, Inflation, and Monetary Policy", "publicationYear": 1977, "publicationDate": "1977-09", "type": "report", "publisher": "National Bureau of Economic Research", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Eytan Sheshinski", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3386/w0203", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/888933169647", "doi": "10.1787/888933169647", "title": "Growth, inflation and monetary policy: Israel", "publicationYear": 2014, "publicationDate": "2014-11-18", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/888933169647", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/aer.101.1.341", "doi": "10.1257/aer.101.1.341", "title": "Monetary Policy, Trend Inflation, and the Great Moderation: An Alternative Interpretation", "publicationYear": 2011, "publicationDate": "2011-02-01", "type": "journal-article", "publisher": "American Economic Association", "containerTitle": "American Economic Review", "volume": "101", "issue": "1", "page": "341-370", "issn": "0002-8282", "isbn": null, "authors": "Olivier Coibion, Yuriy Gorodnichenko", "authorCount": 2, "firstAuthorAffiliation": "Department of Economics, College of William and Mary, 115 Morton Hall, Williamsburg, VA 23187-8795.", "isReferencedByCount": 257, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/aer.101.1.341", "pdfUrl": null, "abstract": "With positive trend inflation, the Taylor principle does not guarantee a determinate equilibrium. We provide new theoretical results on determinacy in New Keynesian models with positive trend inflation and new empirical findings on the Federal Reserve's reaction function before and after the Volcker disinflation to find that, (i) while the Fed likely satisfied the Taylor principle before Volcker, the US economy was still subject to self-fulfilling fluctuations in the 1970s, (ii) the US economy switched to determinacy during the Volcker disinflation, and (iii) the switch reflected changes in the Fed's response to macroeconomic variables and the decline in trend inflation. (JEL E12, E23, E31, E32, E52)", "subject": null, "language": "en", "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/888933339347", "doi": "10.1787/888933339347", "title": "Figure 8. Inflation and monetary policy", "publicationYear": 2016, "publicationDate": "2016-03-07", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/888933339347", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/888932659179", "doi": "10.1787/888932659179", "title": "Figure 7. Inflation and monetary policy", "publicationYear": 2012, "publicationDate": "2012-07-12", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/888932659179", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/888932999393", "doi": "10.1787/888932999393", "title": "Figure 9. Inflation and monetary policy", "publicationYear": 2014, "publicationDate": "2014-02-25", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/888932999393", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.10359", "doi": "10.1257/rct.10359", "title": "Replication of RCT ID AEARCTR-0008592: The ECB's 2021 Monetary Policy Reform in the Eyes of the German Population", "publicationYear": 2022, "publicationDate": "2022-11-04", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Bernd Hayo", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.10359", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/jep.11.2.97", "doi": "10.1257/jep.11.2.97", "title": "Inflation Targeting: A New Framework for Monetary Policy?", "publicationYear": 1997, "publicationDate": "1997-05-01", "type": "journal-article", "publisher": "American Economic Association", "containerTitle": "Journal of Economic Perspectives", "volume": "11", "issue": "2", "page": "97-116", "issn": "0895-3309", "isbn": null, "authors": "Ben S Bernanke, Frederic S Mishkin", "authorCount": 2, "firstAuthorAffiliation": "Class of 1926 Professor of Economics and Public Affairs, Princeton University, Princeton, New Jersey, and Research Associate of the National Bureau of Economic Research, Cambridge, Massachusetts.", "isReferencedByCount": 575, "referenceCount": 18, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/jep.11.2.97", "pdfUrl": null, "abstract": "In recent years, a number of industrialized countries have adopted a strategy for monetary policy known as ‘inflation targeting.’ The authors describe how this approach has been implemented in practice and argue that it is best understood as a broad framework for policy, which allows the central bank ‘constrained discretion,’ rather than as an ironclad policy rule in the Friedman sense. They discuss the potential of the inflation-targeting approach for making monetary policy more coherent and transparent and for increasing monetary policy discipline. The authors' final section addresses some additional practical issues raised by this approach.", "subject": null, "language": "en", "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.3386/w0680", "doi": "10.3386/w0680", "title": "Inflation, Capital Taxation, and Monetary Policy", "publicationYear": 1981, "publicationDate": "1981-05", "type": "report", "publisher": "National Bureau of Economic Research", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Martin Feldstein", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3386/w0680", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.10359-1.0", "doi": "10.1257/rct.10359-1.0", "title": "Replication of RCT ID AEARCTR-0008592: The ECB's 2021 Monetary Policy Reform in the Eyes of the German Population", "publicationYear": 2022, "publicationDate": "2022-11-04", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Bernd Hayo", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.10359-1.0", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.3386/w9321", "doi": "10.3386/w9321", "title": "Asset Price Inflation and Monetary Policy", "publicationYear": 2002, "publicationDate": "2002-11", "type": "report", "publisher": "National Bureau of Economic Research", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Anna Schwartz", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 22, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3386/w9321", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/mac.4.2.33", "doi": "10.1257/mac.4.2.33", "title": "Political Pressures on Monetary Policy During the US Great Inflation", "publicationYear": 2012, "publicationDate": "2012-04-01", "type": "journal-article", "publisher": "American Economic Association", "containerTitle": "American Economic Journal: Macroeconomics", "volume": "4", "issue": "2", "page": "33-64", "issn": "1945-7707, 1945-7715", "isbn": null, "authors": "Charles L Weise", "authorCount": 1, "firstAuthorAffiliation": "Department of Economics, Gettysburg College, 300 N. Washington St., Gettysburg PA 17325.", "isReferencedByCount": 23, "referenceCount": 18, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/mac.4.2.33", "pdfUrl": null, "abstract": "Drawing on an analysis of Federal Open Market Committee (FOMC) documents, this paper argues that political pressures on the Federal Reserve were an important contributor to the rise in inflation in the United States in the 1970s. Members of the FOMC understood that a serious attempt to tackle inflation would generate opposition from Congress and the executive branch. Political considerations contributed to delays in monetary tightening, insufficiently aggressive anti-inflation policies, and the premature abandonment of attempts at disinflation. Empirical analysis verifies that references to the political environment at FOMC meetings are correlated with the stance of monetary policy during this period. (JEL D72, E32, E52, E58, N12)", "subject": null, "language": "en", "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.3386/w33190", "doi": "10.3386/w33190", "title": "Sticky Inflation: Monetary Policy when Debt Drags Inflation Expectations", "publicationYear": 2024, "publicationDate": "2024-11", "type": "report", "publisher": "National Bureau of Economic Research", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Saki Bigio, Nicolas Caramp, Dejanir Silva", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3386/w33190", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/888933388898", "doi": "10.1787/888933388898", "title": "Figure 12. Monetary policy and inflation expectations", "publicationYear": 2016, "publicationDate": "2016-07-13", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/888933388898", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/888933049553", "doi": "10.1787/888933049553", "title": "Economic growth, inflation and monetary policy: Israel", "publicationYear": 2014, "publicationDate": "2014-05-02", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/888933049553", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/aer.102.6.2798", "doi": "10.1257/aer.102.6.2798", "title": "Reset Price Inflation and the Impact of Monetary Policy Shocks", "publicationYear": 2012, "publicationDate": "2012-10-01", "type": "journal-article", "publisher": "American Economic Association", "containerTitle": "American Economic Review", "volume": "102", "issue": "6", "page": "2798-2825", "issn": "0002-8282", "isbn": null, "authors": "Mark Bils, Peter J Klenow, Benjamin A Malin", "authorCount": 3, "firstAuthorAffiliation": "Department of Economics, Harkness Hall, University of Rochester, Rochester, NY 14627.", "isReferencedByCount": 61, "referenceCount": 31, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/aer.102.6.2798", "pdfUrl": null, "abstract": "Many business cycle models use a flat short-run Phillips curve, due to time-dependent pricing and strategic complementarities, to explain fluctuations in real output. But, in doing so, these models predict unrealistically high persistence and stability of US inflation in recent decades. We calculate “reset price inflation”—based on new prices chosen by the subsample of price changers—to dissect this discrepancy. We find that the models generate too much persistence and stability both in reset price inflation and in the way reset price inflation is converted into actual inflation. Our findings present a challenge to existing explanations for business cycles. (JEL E31, E52)", "subject": null, "language": "en", "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1787/888933701775", "doi": "10.1787/888933701775", "title": "Figure 10. Monetary policy and inflation developments", "publicationYear": 2018, "publicationDate": "2018-03-30", "type": "component", "publisher": "Organisation for Economic Co-Operation and Development  (OECD)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1787/888933701775", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.3386/w6157", "doi": "10.3386/w6157", "title": "Inflation Forecasts and Monetary Policy", "publicationYear": 1997, "publicationDate": "1997-09", "type": "report", "publisher": "National Bureau of Economic Research", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Ben Bernanke, Michael Woodford", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 30, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3386/w6157", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.3386/w2300", "doi": "10.3386/w2300", "title": "Monetary Policy Lessons of recent Inflation and Disinflation", "publicationYear": 1987, "publicationDate": "1987-06", "type": "report", "publisher": "National Bureau of Economic Research", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "William Poole", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3386/w2300", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.16834", "doi": "10.1257/rct.16834", "title": "How Inflation Expectations Inform Spending", "publicationYear": 2025, "publicationDate": "2025-09-21", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Aline Scheurer", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.16834", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.3386/w6790", "doi": "10.3386/w6790", "title": "Inflation Targeting as a Monetary Policy Rule", "publicationYear": 1998, "publicationDate": "1998-11", "type": "report", "publisher": "National Bureau of Economic Research", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Lars E.O. Svensson", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 50, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3386/w6790", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.3386/w7482", "doi": "10.3386/w7482", "title": "Understanding Inflation: Implications for Monetary Policy", "publicationYear": 2000, "publicationDate": "2000-01", "type": "report", "publisher": "National Bureau of Economic Research", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Stephen Cecchetti, Erica Groshen", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3386/w7482", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.15732", "doi": "10.1257/rct.15732", "title": "Inflation Expectations in Senegal", "publicationYear": 2025, "publicationDate": "2025-04-03", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Gizem Kosar, Abdoulaye Ndiaye, Anushka Mitra, Ahmadou A. Mbaye", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.15732", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.15732-1.0", "doi": "10.1257/rct.15732-1.0", "title": "Inflation Expectations in Senegal", "publicationYear": 2025, "publicationDate": "2025-04-03", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Gizem Kosar, Abdoulaye Ndiaye, Anushka Mitra, Ahmadou A. Mbaye", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.15732-1.0", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.1257/rct.16834-1.0", "doi": "10.1257/rct.16834-1.0", "title": "How Inflation Expectations Inform Spending", "publicationYear": 2025, "publicationDate": "2025-09-21", "type": "dataset", "publisher": "American Economic Association", "containerTitle": "AEA Randomized Controlled Trials", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Aline Scheurer", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1257/rct.16834-1.0", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "QScE8dHHEgGMFSAht", "_dataset_id": "fcAchFMHYAtxX1m8b"}
{"paperId": "10.5220/0012138800003555", "doi": "10.5220/0012138800003555", "title": "Migrating Applications to Post-Quantum Cryptography: Beyond Algorithm Replacement", "publicationYear": 2023, "publicationDate": "2023", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the 20th International Conference on Security and Cryptography", "volume": null, "issue": null, "page": "857-862", "issn": null, "isbn": null, "authors": "Alexandre Augusto Giron", "authorCount": 1, "firstAuthorAffiliation": "Graduate Program in Computer Science – Federal University of Santa Catarina, Florianópolis-SC, Brazil, --- Select a Country ---", "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0012138800003555", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.5220/0010786200003120", "doi": "10.5220/0010786200003120", "title": "Implementing Post-quantum Cryptography for Developers", "publicationYear": 2022, "publicationDate": "2022", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the 8th International Conference on Information Systems Security and Privacy", "volume": null, "issue": null, "page": "73-83", "issn": null, "isbn": null, "authors": "Julius Hekkala, Kimmo Halunen, Visa Vallivaara", "authorCount": 3, "firstAuthorAffiliation": "VTT Technical Research Centre of Finland, Kaitoväylä 1, Oulu, Finland, --- Select a Country ---", "isReferencedByCount": 6, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0010786200003120", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.26493/978-961-7055-26-9.61-64", "doi": "10.26493/978-961-7055-26-9.61-64", "title": "The problem of quantum computers in cryptography and post-quantum cryptography", "publicationYear": 2010, "publicationDate": "2010-10-01", "type": "proceedings-article", "publisher": "University of Primorska Press", "containerTitle": "StuCoSReC. Proceedings of the 2018 5th Student Computer Science Research Conference.", "volume": null, "issue": null, "page": "61-64", "issn": null, "isbn": null, "authors": "Dino Vlahek", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26493/978-961-7055-26-9.61-64", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.5220/0013091100003899", "doi": "10.5220/0013091100003899", "title": "Quantum-Resilient IoT: Integrating Hardware-Based Post-Quantum Cryptography for Robust Device Security", "publicationYear": 2025, "publicationDate": "2025", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the 11th International Conference on Information Systems Security and Privacy", "volume": null, "issue": null, "page": "419-424", "issn": null, "isbn": null, "authors": "Stephan Spitz, Alexander Lawall, Michal Andrzejczak", "authorCount": 3, "firstAuthorAffiliation": "IU International University of Applied Science, Juri-Gagarin-Ring 152, 99084 Erfurt, Germany", "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0013091100003899", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.5220/0015138600004103", "doi": "10.5220/0015138600004103", "title": "A Capability-Driven Framework for Prioritizing Post-Quantum Cryptography Migration in Enterprise Architectures", "publicationYear": 2026, "publicationDate": "2026", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the 23rd International Conference on Security and Cryptography", "volume": null, "issue": null, "page": "181-192", "issn": null, "isbn": null, "authors": "Francis Naa, Nora Boulahia-Cuppens, Frederic Cuppens", "authorCount": 3, "firstAuthorAffiliation": "Dept. Computer and Software Engineering, Polytechnique Montreal, Canada", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0015138600004103", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.5121/csit.2025.151701", "doi": "10.5121/csit.2025.151701", "title": "HIGH-MEMORY MASKED CONVOLUTIONAL CODES FOR POST-QUANTUM CRYPTOGRAPHY", "publicationYear": 2025, "publicationDate": "2025-09-20", "type": "proceedings-article", "publisher": "Academy & Industry Research Collaboration", "containerTitle": "Cryptography and Information Security Trends 2025", "volume": null, "issue": null, "page": "01-22", "issn": null, "isbn": null, "authors": "Meir Ariel", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5121/csit.2025.151701", "pdfUrl": null, "abstract": "This paper presents a novel post-quantum cryptosystem based on high-memory masked convolutional codes. Unlike conventional code-based schemes that rely on block codes with fixed dimensions and limited error-correction capability, our construction offers both stronger cryptographic security and greater flexibility. It supports arbitrary plaintext lengths with linear-time decryption and uniform per-bit computational cost, enabling seamless scalability to long messages. Security is reinforced through a higher-rate injection of random errors than in block-code approaches, along with additional noise introduced via polynomial division, which substantially obfuscates the underlying code structure. Semi-invertible transformations generate dense, random-like generator matrices that conceal algebraic properties and resist known structural attacks. Consequently, the scheme achieves cryptanalytic security margins exceeding those of the classic McEliece system by factors greater than 2 100. Finally, decryption at the recipient employs an array of parallel Viterbi decoders, enabling efficient hardware and software implementation and positioning the scheme as a strong candidate for deployment in practical quantum-resistant public-key cryptosystems.", "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1145/3733820.3767143", "doi": "10.1145/3733820.3767143", "title": "Advancing Post-Quantum Cryptography: NIST's Standardization Efforts", "publicationYear": 2025, "publicationDate": "2025-10-13", "type": "proceedings-article", "publisher": "ACM", "containerTitle": "Proceedings of the 2025 1st ACM CCS Workshop on Quantum-Resistant Cryptography and Security", "volume": null, "issue": null, "page": "5-5", "issn": null, "isbn": null, "authors": "Dustin Moody", "authorCount": 1, "firstAuthorAffiliation": "National Institute of Standards and Technology, Gaithersburg, Maryland, USA", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1145/3733820.3767143", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.5220/0008162800910098", "doi": "10.5220/0008162800910098", "title": "Paradigm of Post-quantum Cryptography and Crypto-agility: Strategy Approach of Quantum-safe Techniques", "publicationYear": 2019, "publicationDate": "2019", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the 9th International Conference on Pervasive and Embedded Computing and Communication Systems", "volume": null, "issue": null, "page": "91-98", "issn": null, "isbn": null, "authors": "Olaf Grote, Andreas Ahrens, César Benavente-Peces", "authorCount": 3, "firstAuthorAffiliation": "ETS de Ingeniería y Sistemas de Telecomunicación, University Politécnica de Madrid, Campus Sur, Ctra. Valencia, 28031 Madrid and Spain, --- Select a Country ---", "isReferencedByCount": 7, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0008162800910098", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.5220/0013859800004919", "doi": "10.5220/0013859800004919", "title": "Lightweight Quantum Cryptography Integration Framework for Secure IoT-Telecommunication Systems in Post-Quantum Era", "publicationYear": 2025, "publicationDate": "2025", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the 1st International Conference on Research and Development in Information, Communication, and Computing Technologies", "volume": null, "issue": null, "page": "180-186", "issn": null, "isbn": null, "authors": "K. Ajmath, L. Kalaiselvi, Jenifer M., R. Meenakshi, Tandra Nagarjuna, Syed Rashid", "authorCount": 6, "firstAuthorAffiliation": "Department of Computer Science, Samarkand International University of Technology, Uzbekistan", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0013859800004919", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.5220/0010903000003120", "doi": "10.5220/0010903000003120", "title": "Post Quantum Cryptography Analysis of TLS Tunneling on a Constrained Device", "publicationYear": 2022, "publicationDate": "2022", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the 8th International Conference on Information Systems Security and Privacy", "volume": null, "issue": null, "page": "551-561", "issn": null, "isbn": null, "authors": "Jon Barton, William Buchanan, Nikolaos Pitropakis, Sarwar Sayeed, Will Abramson", "authorCount": 5, "firstAuthorAffiliation": "Blockpass ID Lab, School of Computing, Edinburgh Napier University, Edinburgh, U.K., --- Select a Country ---", "isReferencedByCount": 15, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0010903000003120", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/icdsaai65575.2025.11011628", "doi": "10.1109/icdsaai65575.2025.11011628", "title": "Synergizing Quantum Cryptography and Post-Quantum Cryptography: A New Era of Ultra-Secure Data Transmission", "publicationYear": 2025, "publicationDate": "2025-03-28", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 International Conference on Data Science, Agents &amp;amp; Artificial Intelligence (ICDSAAI)", "volume": null, "issue": null, "page": "1-6", "issn": null, "isbn": null, "authors": "A.R Kavitha, Balachandhar R, Harikrishna K", "authorCount": 3, "firstAuthorAffiliation": "Anna University,Chennai Institute of Technology,Dept of Information Technology,Chennai,India,600069", "isReferencedByCount": 4, "referenceCount": 39, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/icdsaai65575.2025.11011628", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/argencon62399.2024.10735956", "doi": "10.1109/argencon62399.2024.10735956", "title": "Current and Future Panorama of Quantum and Post-Quantum Cryptography", "publicationYear": 2024, "publicationDate": "2024-09-18", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2024 IEEE Biennial Congress of Argentina (ARGENCON)", "volume": null, "issue": null, "page": "1-4", "issn": null, "isbn": null, "authors": "Mendilaharzu Claudio, Figueras Fernando", "authorCount": 2, "firstAuthorAffiliation": "Universidad Nacional de San Luis,San Luis,Argentina", "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/argencon62399.2024.10735956", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.5121/csit.2023.132101", "doi": "10.5121/csit.2023.132101", "title": "Lightweight Public Key Encryption in Post-Quantum Computing Era", "publicationYear": 2023, "publicationDate": "2023-11-18", "type": "proceedings-article", "publisher": "Academy & Industry Research Collaboration Center", "containerTitle": "Cryptography and Blockchain", "volume": null, "issue": null, "page": "01-14", "issn": null, "isbn": null, "authors": "Peter Hillmann", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5121/csit.2023.132101", "pdfUrl": null, "abstract": "Confidentiality in our digital world is based on the security of cryptographic algorithms. These are usually executed transparently in the background, with people often relying on them without further knowledge. In the course of technological progress with quantum computers, the protective function of common encryption algorithms is threatened. This particularly affects public-key methods such as RSA and DH based on discrete logarithms and prime factorization. Our concept describes the transformation of a classical asymmetric encryption method to a modern complexity class. Thereby the approach of CramerShoup is put on the new basis of elliptic curves. The system is provable cryptographically strong, especially against adaptive chosen-ciphertext attacks. In addition, the new method features small key lengths, making it suitable for Internet-of-Things. It represents an intermediate step towards an encryption scheme based on isogeny elliptic curves. This approach shows a way to a secure encryption scheme for the post-quantum computing era.", "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/fdtc53659.2021.00015", "doi": "10.1109/fdtc53659.2021.00015", "title": "Safe-Error Analysis of Post-Quantum Cryptography Mechanisms - Short Paper-", "publicationYear": 2021, "publicationDate": "2021-09", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2021 Workshop on Fault Detection and Tolerance in Cryptography (FDTC)", "volume": null, "issue": null, "page": "39-44", "issn": null, "isbn": null, "authors": "Luk Bettale, Simon Montoya, Guenael Renault", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 22, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/fdtc53659.2021.00015", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/icist.2013.6747589", "doi": "10.1109/icist.2013.6747589", "title": "Post-Quantum Crystography: A combination of Post-Quantum Cryptography and Steganography", "publicationYear": 2013, "publicationDate": "2013-12", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2013 IEEE Third International Conference on Information Science and Technology (ICIST)", "volume": null, "issue": null, "page": "449-452", "issn": null, "isbn": null, "authors": "A.J Gabriel, B.K. Alese, A.O. Adetunmbi, O.S. Adewale", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 7, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/icist.2013.6747589", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.23919/indiacom61295.2024.10498577", "doi": "10.23919/indiacom61295.2024.10498577", "title": "Enhancing Post-Quantum Cryptography with Adversarial Neural Cryptography", "publicationYear": 2024, "publicationDate": "2024-02-28", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2024 11th International Conference on Computing for Sustainable Global Development (INDIACom)", "volume": null, "issue": null, "page": "1706-1712", "issn": null, "isbn": null, "authors": "Basil Hanafi, Mohammad Ubaidullah Bokhari, Imran Khan", "authorCount": 3, "firstAuthorAffiliation": "Aligarh Muslim University,Department of Computer Science,Aligarh,India", "isReferencedByCount": 9, "referenceCount": 39, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.23919/indiacom61295.2024.10498577", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/icitst.2013.6750240", "doi": "10.1109/icitst.2013.6750240", "title": "Post-Quantum Crystography: A combination of Post-Quantum Cryptography and Steganography", "publicationYear": 2013, "publicationDate": "2013-12", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "8th International Conference for Internet Technology and Secured Transactions (ICITST-2013)", "volume": null, "issue": null, "page": "449-452", "issn": null, "isbn": null, "authors": "A.J Gabriel, B.K. Alese, A.O. Adetunmbi, O.S. Adewale", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 11, "referenceCount": 14, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/icitst.2013.6750240", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.37962/icydd/2025/70-71", "doi": "10.37962/icydd/2025/70-71", "title": "POST-QUANTUM CRYPTOGRAPHY: CHALLENGES, LIMITATIONS, AND MIGRATION STRATEGIES", "publicationYear": 2025, "publicationDate": "2025-10-25", "type": "proceedings-article", "publisher": "Jinnah University for Women", "containerTitle": "2nd International Conference on Cybersecurity and Digital Defense (ICyDD)", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.37962/icydd/2025/70-71", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.29007/2tpw", "doi": "10.29007/2tpw", "title": "Post-Quantum Cryptography: An Introductory Overview and Implementation Challenges of Quantum-Resistant Algorithms", "publicationYear": 2022, "publicationDate": "2022-06-20", "type": "proceedings-article", "publisher": "EasyChair", "containerTitle": "EPiC Series in Computing", "volume": "84", "issue": null, "page": "61-49", "issn": "2398-7340", "isbn": null, "authors": "Sherdel A. Käppler, Bettina Schneider", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 10, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.29007/2tpw", "pdfUrl": null, "abstract": "Cryptographic algorithms are an essential measure to ensure confidentiality and integrity of internet communication. The development of quantum computers (QCs) and their potential to utilize Shor’s Law, is increasingly recognized as a threat to asymmetric cryptography. In response, post-quantum cryptography (PQC) is gaining prominence as a notable field of research aiming to standardize quantum resistant algorithms before the operational usage of QCs. This paper is addressed to people with preliminary knowledge in the field of cryptography and QC. Based on a literature review, the authors provide an overview of challenges faced by the research community and elaborate the advancements in addressing post-quantum threats. A migration strategy from classical cryptosystems to PQC systems is in development, but obstacles such as time constraints and improper implementation complicate the process. Full implementation could take a decade or more. Until then, our paper aims to create awareness for potential challenges when transitioning towards PQC. As categorization scheme for these potential obstacles, we refer to a well- established model in cybersecurity – the McCumber Cube. Conclusions embrace preparing for risks of improper implementation and deriving a multi-step migration. Special attention is expected to be needed for data migration of existing data sets. As a request for future research in PQC, the authors identified the process of implementing post-cryptography standards, e.g., from the National Institute of Standards and Technology (NIST), and an assessment of the perceived readiness of industry to adapt.", "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/qcnc69040.2026.00088", "doi": "10.1109/qcnc69040.2026.00088", "title": "Obfuscated Quantum and Post-Quantum Cryptography", "publicationYear": 2026, "publicationDate": "2026-04-06", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2026 International Conference on Quantum Communications, Networking, and Computing (QCNC)", "volume": null, "issue": null, "page": "503-512", "issn": null, "isbn": null, "authors": "Anju Rani, Xiaoyu Ai, Aman Gupta, Ravi Singh Adhikari, Robert Malaney", "authorCount": 5, "firstAuthorAffiliation": "School of Electrical Engineering and Telecommunications, University of New South Wales,Sydney,Australia", "isReferencedByCount": 2, "referenceCount": 92, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/qcnc69040.2026.00088", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/mipro65660.2025.11132015", "doi": "10.1109/mipro65660.2025.11132015", "title": "Post-Quantum Cryptography in Secure Instant Messaging Protocols", "publicationYear": 2025, "publicationDate": "2025-06-02", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 MIPRO 48th ICT and Electronics Convention", "volume": null, "issue": null, "page": "855-860", "issn": null, "isbn": null, "authors": "Katarina Boras", "authorCount": 1, "firstAuthorAffiliation": "Faculty of Electrical Engineering and Computing,Zagreb,Croatia", "isReferencedByCount": 1, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/mipro65660.2025.11132015", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/icton62926.2024.10648124", "doi": "10.1109/icton62926.2024.10648124", "title": "Quantum secure communication using hybrid post-quantum cryptography and quantum key distribution", "publicationYear": 2024, "publicationDate": "2024-07-14", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2024 24th International Conference on Transparent Optical Networks (ICTON)", "volume": null, "issue": null, "page": "1-4", "issn": null, "isbn": null, "authors": "Nick Aquina, Simon Rommel, Idelfonso Tafur Monroy", "authorCount": 3, "firstAuthorAffiliation": "Eindhoven University of Technology,Department of Electrical Engineering,Eindhoven,The Netherlands", "isReferencedByCount": 15, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/icton62926.2024.10648124", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.5220/0014999000004103", "doi": "10.5220/0014999000004103", "title": "Federated Attested Custody for Blockchain Assets under Post-Quantum Uncertainty", "publicationYear": 2026, "publicationDate": "2026", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the 23rd International Conference on Security and Cryptography", "volume": null, "issue": null, "page": "591-596", "issn": null, "isbn": null, "authors": "Dominique Bolignano", "authorCount": 1, "firstAuthorAffiliation": "ProvenRun, 77 avenue Niel, Paris, France", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0014999000004103", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/icaisc64594.2025.10959635", "doi": "10.1109/icaisc64594.2025.10959635", "title": "Quantum Cryptography and Post-Quantum Security: Safeguarding Cryptographic Protocols Against Quantum Threats", "publicationYear": 2025, "publicationDate": "2025-02-09", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 2nd International Conference on Advanced Innovations in Smart Cities (ICAISC)", "volume": null, "issue": null, "page": "1-7", "issn": null, "isbn": null, "authors": "Mohammed Ishaque, Bushra Al-Anesi", "authorCount": 2, "firstAuthorAffiliation": "Jeddah International College,Computer Science &#x0026; Information Technology Dept.,Jeddah,Saudi Arabia", "isReferencedByCount": 9, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/icaisc64594.2025.10959635", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.5220/0015169900005051", "doi": "10.5220/0015169900005051", "title": "Ethical AI-Based Health Systems: Analysing Privacy Preserving and Post-Quantum Cryptography Standards for IoT-Based Blockchain Applications", "publicationYear": 2026, "publicationDate": "2026", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the International Conference on Artificial Intelligence and Blockchain in Healthcare", "volume": null, "issue": null, "page": "91-97", "issn": null, "isbn": null, "authors": "Kyriaki Tsantikidou, Nicolas Sklavos", "authorCount": 2, "firstAuthorAffiliation": "SCYTALE Group, Computer Engineering and Informatics Department (CEID), University of Patras, Greece", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0015169900005051", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/icbats66542.2025.11258214", "doi": "10.1109/icbats66542.2025.11258214", "title": "Securing Cryptography in the Quantum Era: A Systematic Review of Post-Quantum Cryptography Solutions", "publicationYear": 2025, "publicationDate": "2025-05-01", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 3rd International Conference on Business Analytics for Technology and Security (ICBATS)", "volume": null, "issue": null, "page": "1-8", "issn": null, "isbn": null, "authors": "Adil Khan, Khawla Khamis, Maitha Al Mesafri, Fatma Mubarak, Rayan Mustafa, Usman Butt", "authorCount": 6, "firstAuthorAffiliation": "College of Engineering and Computing, Liwa University,Al Ain,UAE", "isReferencedByCount": 0, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-009", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/icbats66542.2025.11258214", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.37962/icydd/2024/25-26", "doi": "10.37962/icydd/2024/25-26", "title": "Security in The Quantum Age: Side-Channel Attacks and Countermeasures in Post Quantum Cryptography", "publicationYear": 2024, "publicationDate": "2024-11-23", "type": "proceedings-article", "publisher": "Jinnah University for Women", "containerTitle": "1st International Conference on Cybersecurity and Digital Defense", "volume": null, "issue": null, "page": "25-26", "issn": null, "isbn": null, "authors": "Areesha Nadeem", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.37962/icydd/2024/25-26", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/qcnc64685.2025.00035", "doi": "10.1109/qcnc64685.2025.00035", "title": "Transition of Self-Sovereign Identity to Post-Quantum Cryptography", "publicationYear": 2025, "publicationDate": "2025-03-31", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 International Conference on Quantum Communications, Networking, and Computing (QCNC)", "volume": null, "issue": null, "page": "174-181", "issn": null, "isbn": null, "authors": "Alberto Solavagione, Andrea Vesco", "authorCount": 2, "firstAuthorAffiliation": "LINKS Foundation,Cybersecurity Research Group,Torino,Italy,10138", "isReferencedByCount": 1, "referenceCount": 31, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": "Horizon Europe", "funderIds": "10.13039/100018693", "url": "https://doi.org/10.1109/qcnc64685.2025.00035", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.5220/0012736800003705", "doi": "10.5220/0012736800003705", "title": "Low-Performance Embedded Internet of Things Devices and the Need for Hardware-Accelerated Post-Quantum Cryptography", "publicationYear": 2024, "publicationDate": "2024", "type": "proceedings-article", "publisher": "SCITEPRESS - Science and Technology Publications", "containerTitle": "Proceedings of the 9th International Conference on Internet of Things, Big Data and Security", "volume": null, "issue": null, "page": "329-338", "issn": null, "isbn": null, "authors": "Philipp Grassl, Matthias Hudler, Manuel Koschuch", "authorCount": 3, "firstAuthorAffiliation": "Competence Center for IT-Security, University of Applied Sciences FH Campus Wien, Favoritenstraße 226, 1100 Vienna, Austria, --- Select a Country ---", "isReferencedByCount": 4, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5220/0012736800003705", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1145/3673277.3673313", "doi": "10.1145/3673277.3673313", "title": "Post-Quantum Cryptography Challenges in Connected Vehicles with V2X", "publicationYear": 2024, "publicationDate": "2024-01-19", "type": "proceedings-article", "publisher": "ACM", "containerTitle": "Proceedings of the 2024 3rd International Conference on Cryptography, Network Security and Communication Technology", "volume": null, "issue": null, "page": "205-208", "issn": null, "isbn": null, "authors": "Ge Luo, Jianxin Liu", "authorCount": 2, "firstAuthorAffiliation": "Wuhan Jinyinhu Laboratory, China", "isReferencedByCount": 1, "referenceCount": 9, "isOpenAccess": true, "licenseUrl": "https://www.acm.org/publications/policies/copyright_policy#Background", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1145/3673277.3673313", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/icocics68032.2025.11384041", "doi": "10.1109/icocics68032.2025.11384041", "title": "The Shifted Discrete Logarithm Problem and its Applications in Post-Quantum Cryptography", "publicationYear": 2025, "publicationDate": "2025-10-22", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 IEEE 2nd International Conference on Cryptography, Informatics, and Cybersecurity (ICoCICs)", "volume": null, "issue": null, "page": "198-203", "issn": null, "isbn": null, "authors": "Brayen Damara, Muhammad Imran, Kiki A. Sugeng", "authorCount": 3, "firstAuthorAffiliation": "Universitas Indonesia,Department of Mathematics,Depok,Indonesia", "isReferencedByCount": 0, "referenceCount": 18, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/icocics68032.2025.11384041", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/acm57404.2022.00022", "doi": "10.1109/acm57404.2022.00022", "title": "Performance Evaluation of Classic McEliece Post Quantum Cryptography", "publicationYear": 2022, "publicationDate": "2022-08", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2022 Algorithms, Computing and Mathematics Conference (ACM)", "volume": null, "issue": null, "page": "90-94", "issn": null, "isbn": null, "authors": "Lingeshwaran B, Avtar Singh", "authorCount": 2, "firstAuthorAffiliation": "Nit Jalandhar,Computer science and engineering,Punjab,India", "isReferencedByCount": 0, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/acm57404.2022.00022", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/qce65121.2025.00102", "doi": "10.1109/qce65121.2025.00102", "title": "A Survey of Post-Quantum Cryptography Support in Cryptographic Libraries", "publicationYear": 2025, "publicationDate": "2025-08-30", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 IEEE International Conference on Quantum Computing and Engineering (QCE)", "volume": null, "issue": null, "page": "906-917", "issn": null, "isbn": null, "authors": "Nadeem Ahmed, Lei Zhang, Aryya Gangopadhyay", "authorCount": 3, "firstAuthorAffiliation": "Univ. of Maryland Baltimore County,Department of Information Systems,Baltimore,USA", "isReferencedByCount": 10, "referenceCount": 61, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/qce65121.2025.00102", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1117/12.2677258", "doi": "10.1117/12.2677258", "title": "Quantum-enhanced secure-link architecture with quantum stream cipher Y-00 and post-quantum cryptography: basic structure and experiment", "publicationYear": 2023, "publicationDate": "2023-10-03", "type": "proceedings-article", "publisher": "SPIE", "containerTitle": "Quantum Communications and Quantum Imaging XXI", "volume": null, "issue": null, "page": "11", "issn": null, "isbn": null, "authors": "Kentaro Kato, Fumio Futami, Ken Tanizawa", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 67, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1117/12.2677258", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.1109/rivf68649.2025.11365084", "doi": "10.1109/rivf68649.2025.11365084", "title": "Post-Quantum Cryptography: can Classical Algorithms Resist Quantum Attacks", "publicationYear": 2025, "publicationDate": "2025-12-18", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 RIVF International Conference on Computing and Communication Technologies (RIVF)", "volume": null, "issue": null, "page": "717-722", "issn": null, "isbn": null, "authors": "Dinh Doan Xuan Phuong, Pham Truong Son", "authorCount": 2, "firstAuthorAffiliation": "Le Quy Don Technical University", "isReferencedByCount": 0, "referenceCount": 17, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/rivf68649.2025.11365084", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
{"paperId": "10.66793/titui19proceeding12", "doi": "10.66793/titui19proceeding12", "title": "QUANTUM COMPUTING AND POST-QUANTUM CRYPTOGRAPHY", "publicationYear": 2026, "publicationDate": "2026-06-11", "type": "proceedings-article", "publisher": "Kürşat Çapraz", "containerTitle": "Universitatea Titu Maiorescu, the 19th international conference, education and creativity for a knowledge based society, informatics proceeding book", "volume": null, "issue": null, "page": "75-79", "issn": null, "isbn": null, "authors": "Bogdan ALEXANDRESCU", "authorCount": 1, "firstAuthorAffiliation": "National University of Science and Technology  POLITEHNICA Bucharest", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.66793/titui19proceeding12", "pdfUrl": null, "abstract": "Quantum computing is one of the most significant technological revolutions in the 21st century. Its ability to compute complicated mathematical equations exponentially higher than classical computers poses a risk of becoming outdated to the present cryptographic systems. RSA and Elliptic Curve Cryptography (ECC)-based public key infrastructures are especially susceptible to the Shor algorithm that is capable of factoring large integers and calculating discrete logarithms on a sufficiently large quantum computer. The paper will discuss the principles of quantum computation and their applications in cryptography, as well as a new branch of cryptography, post-quantum cryptography (PQC). It discusses fabrics of key algorithmic contenders, the implementation issues, and the worldwide move to quantum resilient systems. The paper finds that hybrid encryption models, international standardization, and ethical governance are the key elements to achieving the digital future in the quantum era.", "subject": null, "language": null, "_run_id": "kZaVDS3qz0CTH55zI", "_dataset_id": "ZXaj81RNHfsDjFnPp"}
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{"paperId": "10.33483/jfpau.963384", "doi": "10.33483/jfpau.963384", "title": "RNA-DEPENDENT RNA POLYMERASE (RDRP) INHIBITOR DRUGS AGAINST SARS-COV-2: A MOLECULAR DOCKING STUDY", "publicationYear": 2022, "publicationDate": "2022-01-25", "type": "journal-article", "publisher": "Ankara Universitesi Eczacilik Fakultesi Dergisi", "containerTitle": "Ankara Universitesi Eczacilik Fakultesi Dergisi", "volume": null, "issue": null, "page": "62-77", "issn": "1015-3918", "isbn": null, "authors": "Sarah GADO, Zeynep ALAGÖZ", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 23, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.33483/jfpau.963384", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1007/bf00368374", "doi": "10.1007/bf00368374", "title": "A synthetic inhibitor of RNA polymerase", "publicationYear": 1978, "publicationDate": "1978-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Naturwissenschaften", "volume": "65", "issue": "6", "page": "336-336", "issn": "0028-1042, 1432-1904", "isbn": null, "authors": "F. E. Hahn", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 6, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/bf00368374", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/BF00368374.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1358/dof.2021.46.12.3331694", "doi": "10.1358/dof.2021.46.12.3331694", "title": "Molnupiravir. RNA-directed RNA polymerase (RdRp) inhibitor, Treatment of mild to moderate COVID-19", "publicationYear": 2021, "publicationDate": "2021", "type": "journal-article", "publisher": "Portico", "containerTitle": "Drugs of the Future", "volume": "46", "issue": "12", "page": "977", "issn": "2013-0368", "isbn": null, "authors": "Kaul, G., Dasgupta, A., Chopra, S.", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1358/dof.2021.46.12.3331694", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1261/rna.078776.121", "doi": "10.1261/rna.078776.121", "title": "Ribosomal RNA degradation induced by the bacterial RNA polymerase inhibitor rifampicin", "publicationYear": 2021, "publicationDate": "2021-08", "type": "journal-article", "publisher": "Cold Spring Harbor Laboratory", "containerTitle": "RNA", "volume": "27", "issue": "8", "page": "946-958", "issn": "1355-8382, 1469-9001", "isbn": null, "authors": "Lina Hamouche, Leonora Poljak, Agamemnon J. Carpousis", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 37, "referenceCount": 58, "isOpenAccess": true, "licenseUrl": null, "funderNames": "Agence Nationale de la Recherche", "funderIds": "10.13039/501100001665", "url": "https://doi.org/10.1261/rna.078776.121", "pdfUrl": null, "abstract": "Rifampicin, a broad-spectrum antibiotic, inhibits bacterial RNA polymerase. Here we show that rifampicin treatment of Escherichia coli results in a 50% decrease in cell size due to a terminal cell division. This decrease is a consequence of inhibition of transcription as evidenced by an isogenic rifampicin-resistant strain. There is also a 50% decrease in total RNA due mostly to a 90% decrease in 23S and 16S rRNA levels. Control experiments showed this decrease is not an artifact of our RNA purification protocol and therefore due to degradation in vivo. Since chromosome replication continues after rifampicin treatment, ribonucleotides from rRNA degradation could be recycled for DNA synthesis. Rifampicin-induced rRNA degradation occurs under different growth conditions and in different strain backgrounds. However, rRNA degradation is never complete, thus permitting the reinitiation of growth after removal of rifampicin. The orderly shutdown of growth under conditions where the induction of stress genes is blocked by rifampicin is noteworthy. Inhibition of protein synthesis by chloramphenicol resulted in a partial decrease in 23S and 16S rRNA levels whereas kasugamycin treatment had no effect. Analysis of temperature-sensitive mutant strains implicate RNase E, PNPase, and RNase R in rifampicin-induced rRNA degradation. We cannot distinguish between a direct role for RNase E in rRNA degradation versus an indirect role involving a slowdown of mRNA degradation. Since mRNA and rRNA appear to be degraded by the same ribonucleases, competition by rRNA is likely to result in slower mRNA degradation rates in the presence of rifampicin than under normal growth conditions.", "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1126/science.1134830", "doi": "10.1126/science.1134830", "title": "Synthesis-Mediated Release of a Small RNA Inhibitor of RNA Polymerase", "publicationYear": 2006, "publicationDate": "2006-12-08", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "314", "issue": "5805", "page": "1601-1603", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "Karen M. Wassarman, Ruth M. Saecker", "authorCount": 2, "firstAuthorAffiliation": "Department of Bacteriology, University of Wisconsin–Madison, Madison, WI 53706, USA.", "isReferencedByCount": 153, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.1134830", "pdfUrl": null, "abstract": "Noncoding small RNAs regulate gene expression in all organisms, in some cases through direct association with RNA polymerase (RNAP). Here we report that the mechanism of 6 S RNA inhibition of transcription is through specific, stable interactions with the active site of Escherichia coli RNAP that exclude promoter DNA binding. In fact, the DNA-dependent RNAP uses bound 6 S RNA as a template for RNA synthesis, producing 14-to 20-nucleotide RNA products (pRNA). These results demonstrate that 6 S RNA is functionally engaged in the active site of RNAP. Synthesis of pRNA destabilizes 6 S RNA–RNAP complexes leading to release of the pRNA-6 S RNA hybrid. In vivo, 6 S RNA–directed RNA synthesis occurs during outgrowth from the stationary phase and likely is responsible for liberating RNAP from 6 S RNA in response to nutrient availability.", "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.17352/aaa.000003", "doi": "10.17352/aaa.000003", "title": "Thiolutin Derivatives as inhibitor of RNA-Dependent RNA Polymerase (RdRP) of Hepatitis C Virus: An In-silico Approach", "publicationYear": 2018, "publicationDate": "2018-01-26", "type": "journal-article", "publisher": "Peertechz Publications Private Limited", "containerTitle": "Annals of Antivirals and Antiretrovirals", "volume": null, "issue": null, "page": "001-001", "issn": null, "isbn": null, "authors": "Qadir Muhammad Imran", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 8, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.17352/aaa.000003", "pdfUrl": "https://www.peertechzpublications.com/articles/AAA-2-103.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1016/j.bpj.2014.11.2900", "doi": "10.1016/j.bpj.2014.11.2900", "title": "Thumb II Site Inhibitor Allosterically Suppresses the Dynamics of HCV RNA-Dependent RNA Polymerase", "publicationYear": 2015, "publicationDate": "2015-01", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Biophysical Journal", "volume": "108", "issue": "2", "page": "529a", "issn": "0006-3495", "isbn": null, "authors": "Daniel J. Deredge, Kenneth Johnson, Patrick Wintrode", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.bpj.2014.11.2900", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1358/dof.2021.46.2.3176879", "doi": "10.1358/dof.2021.46.2.3176879", "title": "TNP-2092. RNA polymerase (bacterial) inhibitor, DNA gyrase (bacterial) inhibitor, DNA topoisomerase IV (bacterial) inhibitor, Treatment of medical device-associated bacterial biofilm infections", "publicationYear": 2021, "publicationDate": "2021", "type": "journal-article", "publisher": "Portico", "containerTitle": "Drugs of the Future", "volume": "46", "issue": "2", "page": "129", "issn": "2013-0368", "isbn": null, "authors": "Takare, R., Dasgupta, A., Chopra, S.", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1358/dof.2021.46.2.3176879", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1016/s0168-8278(07)62037-6", "doi": "10.1016/s0168-8278(07)62037-6", "title": "[439] ADDITIVE TO SYNERGISTIC ANTIVIRAL EFFECTS OF AN NS3/4A PROTEASE INHIBITOR (ITMN-191) AND AN NS5B RNA-DEPENDENT RNA POLYMERASE INHIBITOR (R1479) IN AN HCV REPLICON SYSTEM", "publicationYear": 2007, "publicationDate": "2007-04", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Hepatology", "volume": "46", "issue": null, "page": "S167", "issn": "0168-8278", "isbn": null, "authors": "S.D. Seiwert, H. Tan, L.M. Blatt", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0168-8278(07)62037-6", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1099/mic.0.062547-0", "doi": "10.1099/mic.0.062547-0", "title": "Substitutions in the Escherichia coli RNA polymerase inhibitor T7 Gp2 that allow inhibition of transcription when the primary interaction interface between Gp2 and RNA polymerase becomes compromised", "publicationYear": 2012, "publicationDate": "2012-11-01", "type": "journal-article", "publisher": "Microbiology Society", "containerTitle": "Microbiology", "volume": "158", "issue": "11", "page": "2753-2764", "issn": "1350-0872, 1465-2080", "isbn": null, "authors": "Andrey Shadrin, Carol Sheppard, Konstantin Severinov, Steve Matthews, Sivaramesh Wigneshweraraj", "authorCount": 5, "firstAuthorAffiliation": "Section of Microbiology and MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, UK", "isReferencedByCount": 12, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1099/mic.0.062547-0", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1158/1538-7445.am2024-5597", "doi": "10.1158/1538-7445.am2024-5597", "title": "Abstract 5597: Clinical significance of RNA polymerase I inhibitor in pancreatic cancer therapy", "publicationYear": 2024, "publicationDate": "2024-03-22", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Research", "volume": "84", "issue": "6_Supplement", "page": "5597-5597", "issn": "1538-7445", "isbn": null, "authors": "Mudassier Ahmad", "authorCount": 1, "firstAuthorAffiliation": "1University of Texas Rio Grande Valley, McAllen, TX.", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/1538-7445.am2024-5597", "pdfUrl": "https://aacrjournals.org/cancerres/article/84/6_Supplement/5597/741729/Abstract-5597-Clinical-significance-of-RNA", "abstract": "Abstract Pancreatic cancer (PanCa) is the third leading cause of cancer-related deaths in the United States with limited therapeutic options available. Gemcitabine (GEM), a deoxycytidine nucleoside analog is currently considered the most effective therapy for PanCa. However, it shows only a marginal survival benefit of six months. Aberrant ribosome biogenesis occurs in most tumor types. We observed that PanCa cells are addicted to ribosome biogenesis (RiBi), which supports their highly aggressive metastatic phenotypes. Thus, strategically targeting RiBi process could be one of the ideal strategies for the prevention and treatment of PanCa. In this study, we elucidated the molecular mechanisms of POLR1A (RPA194) overexpression and how its targeting along with p53 status impacts RNA polymerase I inhibitor therapy against PanCa. The expression level of RPA194 was significantly elevated in pancreatic tumor tissues when compared with adjacent normal pancreatic tissues. BMH-21 is a potent pharmacological inhibitor of RNA Pol I, which is known to degrade RPA194 protein. Our results demonstrated that BMH-21 can selectively induce apoptosis in various PanCa cells but not in HPNE cells. We also found that the cytotoxic effect of BMH-21 was dependent on the expression pattern of RPA-194 and p53 status. We further examined the therapeutic efficacy of BMH-21 in orthotopic xenograft mouse models by using two different PanCa cells, AsPC1 which contains non-functional p53 and MIA PaCa-2 which contains functional mutant p53. We observed that BMH-21 significantly inhibited the growth of tumors derived from both cancer cell lines. Interestingly, BMH-21-mediated inhibition of tumor growth was more significant in tumors derived from MIA PaCa-2 cells compared to AsPC1 cells. Further examination revealed that the inhibition of tumor growth was correlated with RPA194 degradation followed by inhibition of cell proliferation. Overall, our results strongly suggest that BMH-21 is a promising non-toxic agent for the treatment of advanced PanCa and its therapeutic potential depends on RPA194 expression and p53 status in PanCa cells. Citation Format: Mudassier Ahmad. Clinical significance of RNA polymerase I inhibitor in pancreatic cancer therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5597.", "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1358/dof.2020.45.6.3146067", "doi": "10.1358/dof.2020.45.6.3146067", "title": "Remdesivir. RNA-dependent RNA polymerase inhibitor, Treatment of Ebola virus infection, Treatment of SARS-CoV-2 infection (COVID-19)", "publicationYear": 2020, "publicationDate": "2020", "type": "journal-article", "publisher": "Portico", "containerTitle": "Drugs of the Future", "volume": "45", "issue": "6", "page": "369", "issn": "2013-0368", "isbn": null, "authors": "Ahmad, M.N., Dasgupta, A., Chopra, S.", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1358/dof.2020.45.6.3146067", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.3844/ojbsci.2011.48.62", "doi": "10.3844/ojbsci.2011.48.62", "title": "Molecular Dynamics Simulation of DENV RNA-Dependent RNA-Polymerase with Potential Inhibitor of Disulfide Cyclic Peptide", "publicationYear": 2011, "publicationDate": "2011-02-01", "type": "journal-article", "publisher": "Science Publications", "containerTitle": "OnLine Journal of Biological Sciences", "volume": "11", "issue": "2", "page": "48-62", "issn": "1608-4217", "isbn": null, "authors": "Usman", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3844/ojbsci.2011.48.62", "pdfUrl": "http://thescipub.com/PDF/ojbsci.2011.48.62.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.7454/psr.v9i2.1236", "doi": "10.7454/psr.v9i2.1236", "title": "Discovery of SARS-CoV-2 RNA-dependent-RNA-polymerase (RdRp) Inhibitor from Sambiloto (Andrographis paniculata) Based on Molecular Docking and ADMET Prediction Approach", "publicationYear": 2022, "publicationDate": "2022-08-01", "type": "journal-article", "publisher": "Universitas Indonesia", "containerTitle": "Pharmaceutical Sciences and Research", "volume": "9", "issue": "2", "page": null, "issn": "2407-2354, 2477-0612", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.7454/psr.v9i2.1236", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.3851/imp2088", "doi": "10.3851/imp2088", "title": "Resistance to Mericitabine, a Nucleoside Analogue Inhibitor of HCV Rna-Dependent RNA Polymerase", "publicationYear": 2012, "publicationDate": "2012-04", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Antiviral Therapy", "volume": "17", "issue": "3", "page": "411-423", "issn": "1359-6535, 2040-2058", "isbn": null, "authors": "Jean-Michel Pawlotsky, Isabel Najera, Ira Jacobson", "authorCount": 3, "firstAuthorAffiliation": "National Reference Center for Viral Hepatitis B, C and D, Department of Virology, Hôpital Henri Mondor, Université Paris-Est, Créteil, France", "isReferencedByCount": 34, "referenceCount": 62, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3851/imp2088", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.3851/IMP2088", "abstract": "Mericitabine (RG7128), an orally administered prodrug of PSI-6130, is the most clinically advanced nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV. This review describes what has been learnt so far about the resistance profile of mericitabine. A serine to threonine substitution at position 282 (S282T) of the RdRp that reduces its replication capacity to approximately 15% of wild-type is the only variant that has been consistently generated in serial in vitro passage experiments. To date, no evidence of genotypic resistance to mericitabine has been detected by population or clonal sequence analysis in any baseline or on-treatment samples collected from &gt;600 patients enrolled in Phase I/II trials of mericitabine administered as monotherapy, in combination with pegylated interferon/ ribavirin, or in combination with the protease inhibitor, danoprevir, for 14 days in the proof-of-concept study of interferon-free therapy.", "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1128/jvi.66.4.1971-1976.1992", "doi": "10.1128/jvi.66.4.1971-1976.1992", "title": "Gliotoxin: inhibitor of poliovirus RNA synthesis that blocks the viral RNA polymerase 3Dpol", "publicationYear": 1992, "publicationDate": "1992-04", "type": "journal-article", "publisher": "American Society for Microbiology", "containerTitle": "Journal of Virology", "volume": "66", "issue": "4", "page": "1971-1976", "issn": "0022-538X, 1098-5514", "isbn": null, "authors": "P L Rodriguez, L Carrasco", "authorCount": 2, "firstAuthorAffiliation": "Centro de Biología Molecular, Universidad Autónoma, Madrid, Spain.", "isReferencedByCount": 60, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://journals.asm.org/non-commercial-tdm-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1128/jvi.66.4.1971-1976.1992", "pdfUrl": "https://journals.asm.org/doi/pdf/10.1128/jvi.66.4.1971-1976.1992", "abstract": "The mode of action of gliotoxin against poliovirus has been analyzed in detail. This fungal metabolite inhibits the appearance of poliovirus proteins when present from the beginning of infection but has no effect on viral translation when added at late times. In agreement with previous findings, this toxin potently inhibited the incorporation of [3H]uridine into poliovirus RNA soon after its addition to the culture medium. Analysis of the synthesis of poliovirus plus- or minus-stranded RNA in the presence of gliotoxin suggests that this compound effectively hampered both processes. This result contrasts with the mode of action of other inhibitors of poliovirus RNA synthesis, such as guanidine or flavones, that selectively block plus-stranded RNA synthesis and suggests that the target of gliotoxin differs from the target of guanidine, i.e., poliovirus protein 2C. Indeed, gliotoxin was found to be a potent inhibitor of poliovirus RNA synthesis in cell-free systems, using membranous crude replication complexes, a reaction that is not blocked by guanidine or Ro 09-0179. Moreover, in vitro activity of the purified poliovirus polymerase 3Dpol was efficiently inhibited by gliotoxin. These results indicate that this toxin acts on the poliovirus polymerase 3Dpol, providing the first description of an inhibitor of this viral enzyme.", "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1099/0022-1317-18-1-11", "doi": "10.1099/0022-1317-18-1-11", "title": "An Inhibitor of the Particle-associated RNA-dependent RNA Polymerase of Influenza A and B Viruses", "publicationYear": 1973, "publicationDate": "1973-01-01", "type": "journal-article", "publisher": "Microbiology Society", "containerTitle": "Journal of General Virology", "volume": "18", "issue": "1", "page": "11-19", "issn": "0022-1317, 1465-2099", "isbn": null, "authors": "J. S. Oxford", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 21, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1099/0022-1317-18-1-11", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1016/j.insi.2026.100275", "doi": "10.1016/j.insi.2026.100275", "title": "Thevetiaflavone as a novel dengue serotype 3 Rna-dependent rna polymerase inhibitor: Insights from molecular docking and pharmacokinetic predictions", "publicationYear": 2026, "publicationDate": "2026", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "In Silico Research in Biomedicine", "volume": "2", "issue": null, "page": "100275", "issn": "3050-7871", "isbn": null, "authors": "Jaganathan Padmanabhan", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.insi.2026.100275", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1159/000469583", "doi": "10.1159/000469583", "title": "Effect of Tumour Growth on Hepatic Neutral Ribonuclease and Its Inhibitor and on RNA Polymerase Activity of Liver Nuclei", "publicationYear": 2017, "publicationDate": "2017-08-11", "type": "journal-article", "publisher": "S. Karger AG", "containerTitle": "Enzyme", "volume": null, "issue": null, "page": "239-243", "issn": "0013-9432, 2504-2564", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://karger.com/pages/terms-and-conditions", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1159/000469583", "pdfUrl": null, "abstract": "In rats bearing a subcutaneously implanted Walker 256 carcinoma an early rise in liver DNA content was followed by a two-fold increase in RNA content between the 6th and 10th day of tumour growth. Total hepatic neutral ribonuclease and its inhibitor were unaffected by tumour growth. No alteration in RNA polymerase I and II activities of liver nuclei was observed except for a 47 % increase in RNA polymerase I on the 8th day of tumour growth.", "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.4172/2329-9533.1000113", "doi": "10.4172/2329-9533.1000113", "title": "Identification of Potent Inhibitor for RNA Dependent RNA Polymerase (RDRP) of Dengue Virus Serotype-3: A Molecular Docking Study", "publicationYear": 2015, "publicationDate": "2015", "type": "journal-article", "publisher": "OMICS Publishing Group", "containerTitle": "Journal of Applied Bioinformatics &amp; Computational Biology", "volume": "04", "issue": "01", "page": null, "issn": "2329-9533", "isbn": null, "authors": "Sankarasubramanian J", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4172/2329-9533.1000113", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1016/s0021-9258(18)45253-2", "doi": "10.1016/s0021-9258(18)45253-2", "title": "Inhibition of the RNA polymerase-catalyzed synthesis of RNA by daunomycin. Effect of the inhibitor on the late steps of RNA chain initiation.", "publicationYear": 1987, "publicationDate": "1987-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Biological Chemistry", "volume": "262", "issue": "26", "page": "12632-12640", "issn": "0021-9258", "isbn": null, "authors": "T Kriebardis, D Meng, S Aktipis", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0021-9258(18)45253-2", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.2174/22123989mta4unteoz", "doi": "10.2174/22123989mta4unteoz", "title": "In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA Dependent RNA polymerase (RdRp) and Essential Proteases.", "publicationYear": 2021, "publicationDate": "2021", "type": "journal-article", "publisher": "Bentham Science Publishers Ltd.", "containerTitle": "Infectious Disorders - Drug Targets", "volume": "21", "issue": "4", "page": "608-618", "issn": "2212-3989", "isbn": null, "authors": "Trinath Chowdhury", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2174/22123989mta4unteoz", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1096/fasebj.29.1_supplement.lb81", "doi": "10.1096/fasebj.29.1_supplement.lb81", "title": "Thumb II Site Inhibitor Allosterically Suppresses the Dynamics of HCV NS5B RNA‐Dependent RNA Polymerase", "publicationYear": 2015, "publicationDate": "2015-04", "type": "journal-article", "publisher": "Wiley", "containerTitle": "The FASEB Journal", "volume": "29", "issue": "S1", "page": null, "issn": "0892-6638, 1530-6860", "isbn": null, "authors": "Bhavna Jois, Daniel Deredge, Kenneth Johnson, Patrick Wintrode", "authorCount": 4, "firstAuthorAffiliation": "Department of Chemistry and Biochemistry University of Maryland Baltimore County Baltimore Maryland United States", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1096/fasebj.29.1_supplement.lb81", "pdfUrl": null, "abstract": "The NS5B RNA‐dependent RNA polymerase of human hepatitis C virus (HCV) is a major target for drug development in the search for an effective treatment of hepatitis C. Various nucleoside analogs and allosteric non‐nucleoside inhibitors, classified based on the drug binding site, have been shown to bind NS5B and inhibit HCV replication. However, the genetic diversity of HCV and the rapid development of resistance mutations have stressed the need for better understanding of the mechanism of inhibition at a molecular level. With this intention, we have used hydrogen/deuterium exchange coupled with mass spectrometry to characterize the local dynamics of NS5B in the presence and absence of these inhibitors. We have verified that the inhibitor binding to the polymerase causes significant loss of exchange at the binding site and in regions adjacent. Additionally, we have seen that large regions of NS5B that are distant from the drug‐binding site show a significant loss in protein dynamics as detected by H/D exchange. This allosteric inhibition encompasses specific regions of NS5B that are involved in its catalytic cycle, including the fingers, finger extensions and thumb. Funding Source: University of Maryland School of Pharmacy", "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1038/350439a0", "doi": "10.1038/350439a0", "title": "Blocking of Tat-dependent HIV-1 RNA modification by an inhibitor of RNA polymerase II processivity", "publicationYear": 1991, "publicationDate": "1991-04", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "350", "issue": "6317", "page": "439-441", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Martin Braddock, Andrew M. Thorburn, Alan J. Kingsman, Susan M. Kingsman", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 42, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/350439a0", "pdfUrl": "http://www.nature.com/articles/350439a0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.56042/ijnpr.v12i4.43764", "doi": "10.56042/ijnpr.v12i4.43764", "title": "Terpenoids from Centella asiatica, a novel inhibitor against RNA-dependent-RNA polymerase activity of NSP12 of the SARS CoV-2 (COVID-19)", "publicationYear": 2022, "publicationDate": "2022", "type": "journal-article", "publisher": "CSIR-National Institute of Science Communication and Policy Research (NIScPR)", "containerTitle": "Indian Journal of Natural Products and Resources", "volume": null, "issue": null, "page": null, "issn": "0976-0504, 0976-0512", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.56042/ijnpr.v12i4.43764", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1006/viro.1996.0639", "doi": "10.1006/viro.1996.0639", "title": "RNA Polymerase Activity Catalyzed by a Potyvirus-Encoded RNA-Dependent RNA Polymerase", "publicationYear": 1996, "publicationDate": "1996-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Virology", "volume": "226", "issue": "1", "page": "146-151", "issn": "0042-6822", "isbn": null, "authors": "Yiling Hong, Arthur G. Hunt", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 88, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1006/viro.1996.0639", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1021/bi00619a029", "doi": "10.1021/bi00619a029", "title": "Escherichia coli RNA polymerase-rifampicin complexes bound at promoter sites block RNA chain elongation by Escherichia coli/RNA polymerase and T7-specific RNA polymerase", "publicationYear": 1978, "publicationDate": "1978-12-01", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Biochemistry", "volume": "17", "issue": "26", "page": "5798-5804", "issn": "0006-2960, 1520-4995", "isbn": null, "authors": "George A. Kassavetis, Kathleen M. Kaya, Michael J. Chamberlin", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 26, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/bi00619a029", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1016/s0960-894x(04)00460-3", "doi": "10.1016/s0960-894x(04)00460-3", "title": "The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase", "publicationYear": 2004, "publicationDate": "2004-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Bioorganic &amp; Medicinal Chemistry Letters", "volume": "14", "issue": "12", "page": "3257-3261", "issn": "0960-894X", "isbn": null, "authors": "P PACE", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0960-894x(04)00460-3", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1016/j.antiviral.2016.09.007", "doi": "10.1016/j.antiviral.2016.09.007", "title": "Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor", "publicationYear": 2016, "publicationDate": "2016-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Antiviral Research", "volume": "134", "issue": null, "page": "226-235", "issn": "0166-3542", "isbn": null, "authors": "Delia Tarantino, Rolando Cannalire, Eloise Mastrangelo, Romina Croci, Gilles Querat, Maria Letizia Barreca, Martino Bolognesi, Giuseppe Manfroni, Violetta Cecchetti, Mario Milani", "authorCount": 10, "firstAuthorAffiliation": null, "isReferencedByCount": 68, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.antiviral.2016.09.007", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.37358/rc.20.11.8376", "doi": "10.37358/rc.20.11.8376", "title": "Potency of Three Brown Seaweeds Species as the Inhibitor of RNA-dependent RNA Polymerase of SARS-CoV-2", "publicationYear": 2020, "publicationDate": "2020-12-04", "type": "journal-article", "publisher": "Revista de Chimie SRL", "containerTitle": "Revista de Chimie", "volume": "71", "issue": "11", "page": "80-86", "issn": "0034-7752, 2668-8212", "isbn": null, "authors": "Muhamad Firdaus, Rahmi Nurdiani, Indri Novita Artasasta, Sayyidah Mutoharoh, Oni Pratiwi", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.37358/rc.20.11.8376", "pdfUrl": "https://revistadechimie.ro/pdf/9%20FIRDAUS%2011%2020.pdf", "abstract": "The objective of this study was to evaluate the binding activity of bioactive compounds from three brown seaweed on RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 by docking method. The bioactive identification of Sargassum cristaefolium, S. echinocarpum, and Padina australis was carried out using HPLC-HRMS. The ligand structures in PDB format were obtained from the PubChem website and the RdRp from the RCSB website. The binding affinity of the interaction of bioactive components with the RdRp Covid-19 was determined by docking method using AutoDock Vina on PyRx software. The visualization of 2D and 3D interactions between ligands and macromolecules were carried out with the Biovia Discovery Studio and PyMol software. The decoction of S. cristaefolium, S. echinocarpum, and P. australis contained ninety one compounds, and there were twenty compounds with a strong affinity for RdRp. Rhamnetin was a compound of the Sargassum species have the strongest binding affinity of -7.6 kcal/mol. Its affinity bonds were hydrogen bonds in Val315, Arg349, Phe396, Asn628, and hydrophobic bonds in the form of bonds to - and -alkyl from Pro461. Taribavirin bound to RdRp in hydrogen bonds at Thr393, Thr394, and Phe396 and bound hydrophobically to -alkyl from Cys395. Rhamnetin has the same binding affinity region as taribavirin, which was the subdomain finger of the RdRp. In conclusion, rhamnetin is a compound of Sargassum sp that can inhibit the replication and transcription of RdRp SARS-CoV-2 and further studies using the molecular dynamics method on the mechanism of interaction between rhamnetin and the viral RdRp of SARS-CoV-2 are mandatory.", "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1002/ange.201200871", "doi": "10.1002/ange.201200871", "title": "Total Synthesis of the Bacterial RNA Polymerase Inhibitor Ripostatin B", "publicationYear": 2012, "publicationDate": "2012-04-02", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Angewandte Chemie", "volume": "124", "issue": "14", "page": "3461-3465", "issn": "0044-8249, 1521-3757", "isbn": null, "authors": "Florian Glaus, Karl‐Heinz Altmann", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 14, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/ange.201200871", "pdfUrl": null, "abstract": null, "subject": null, "language": "de", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1016/s0168-8278(10)60741-6", "doi": "10.1016/s0168-8278(10)60741-6", "title": "739 DISCOVERY OF A NOVEL, POTENT FLAVONOID INHIBITOR OF HCV RNA-DEPENDENT RNA POLYMERASE", "publicationYear": 2010, "publicationDate": "2010-04", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Hepatology", "volume": "52", "issue": null, "page": "S288", "issn": "0168-8278", "isbn": null, "authors": "A. Ahmed-Belkacem, R. Brillet, C. Pallier, C. Wychowski, J.-F. Guichou, J.-M. Pawlotsky", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0168-8278(10)60741-6", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1038/2261209a0", "doi": "10.1038/2261209a0", "title": "Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses", "publicationYear": 1970, "publicationDate": "1970-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "226", "issue": "5252", "page": "1209-1211", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "DAVID BALTIMORE", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1626, "referenceCount": 17, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/2261209a0", "pdfUrl": "http://www.nature.com/articles/2261209a0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1074/jbc.rev120.013746", "doi": "10.1074/jbc.rev120.013746", "title": "Mechanistic cross-talk between DNA/RNA polymerase enzyme kinetics and nucleotide substrate availability in cells: Implications for polymerase inhibitor discovery", "publicationYear": 2020, "publicationDate": "2020-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Biological Chemistry", "volume": "295", "issue": "39", "page": "13432-13443", "issn": "0021-9258", "isbn": null, "authors": "Si'Ana A. Coggins, Bijan Mahboubi, Raymond F. Schinazi, Baek Kim", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 146, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1074/jbc.rev120.013746", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1006/jmbi.2000.4309", "doi": "10.1006/jmbi.2000.4309", "title": "RNA Polymerase: Structural Similarities Between Bacterial RNA Polymerase and Eukaryotic RNA Polymerase II", "publicationYear": 2000, "publicationDate": "2000-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Molecular Biology", "volume": "304", "issue": "5", "page": "687-698", "issn": "0022-2836", "isbn": null, "authors": "Richard H. Ebright", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 217, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institutes of Health, National Institutes of Health", "funderIds": "10.13039/100000002, 10.13039/100000002", "url": "https://doi.org/10.1006/jmbi.2000.4309", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1093/emboj/17.14.4101", "doi": "10.1093/emboj/17.14.4101", "title": "Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme", "publicationYear": 1998, "publicationDate": "1998-07-15", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "The EMBO Journal", "volume": "17", "issue": "14", "page": "4101-4113", "issn": "0261-4189, 1460-2075", "isbn": null, "authors": "David Jeruzalmi, Thomas A Steitz", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 157, "referenceCount": 79, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/emboj/17.14.4101", "pdfUrl": "https://link.springer.com/content/pdf/10.1093/emboj/17.14.4101.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.2174/1871526520666200727153643", "doi": "10.2174/1871526520666200727153643", "title": "In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA Dependent RNA polymerase (RdRp) and Essential Proteases", "publicationYear": 2021, "publicationDate": "2021-06", "type": "journal-article", "publisher": "Bentham Science Publishers Ltd.", "containerTitle": "Infectious Disorders - Drug Targets", "volume": "21", "issue": "4", "page": "608-618", "issn": "1871-5265", "isbn": null, "authors": "Trinath Chowdhury, Gourisankar Roymahapatra, Santi M. Mandal", "authorCount": 3, "firstAuthorAffiliation": "Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur 721302,India", "isReferencedByCount": 7, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2174/1871526520666200727153643", "pdfUrl": "https://www.eurekaselect.com/article/download/184168", "abstract": "Background: COVID-19 is a life-threatening novel corona viral infection to our civilization and spreading rapidly. Tremendousefforts have been made by the researchers to search for a drug to control SARS-CoV-2. Methods: Here, a series of arsenical derivatives were optimized and analyzed with in silico study to search the inhibitor of RNA dependent RNA polymerase (RdRp), the major replication factor of SARS-CoV-2. All the optimized derivatives were blindly docked with RdRp of SARS-CoV-2 using iGEMDOCK v2.1. Results: Based on the lower idock score in the catalytic pocket of RdRp, darinaparsin (-82.52 kcal/- mol) was revealed to be the most effective among them. Darinaparsin strongly binds with both Nsp9 replicase protein (-8.77 kcal/mol) and Nsp15 endoribonuclease (-8.3 kcal/mol) of SARS-- CoV-2 as confirmed from the AutoDock analysis. During infection, the ssRNA of SARS-CoV-2 is translated into large polyproteins forming viral replication complex by specific proteases like 3CL protease and papain protease. This is also another target to control the virus infection where darinaparsin also performs the inhibitory role to proteases of 3CL protease (-7.69 kcal/mol) and papain protease (-8.43 kcal/mol). Conclusion: In the host cell, the furin protease serves as a gateway to the viral entry and darinaparsin docked with furin protease, which revealed a strong binding affinity. Thus, screening of potential arsenic drugs would help in providing the fast in-vitro to in-vivo analysis towards the development of therapeutics against SARS-CoV-2.", "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1002/ange.201108749", "doi": "10.1002/ange.201108749", "title": "Total Synthesis of RNA‐Polymerase Inhibitor Ripostatin B and 15‐Deoxyripostatin A", "publicationYear": 2012, "publicationDate": "2012-04-02", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Angewandte Chemie", "volume": "124", "issue": "14", "page": "3457-3460", "issn": "0044-8249, 1521-3757", "isbn": null, "authors": "Wufeng Tang, Evgeny V. Prusov", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/ange.201108749", "pdfUrl": null, "abstract": null, "subject": null, "language": "de", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.6026/97320630006221", "doi": "10.6026/97320630006221", "title": "Binding mode prediction and inhibitor design of anti-influenza virus diketo acids targeting metalloenzyme RNA polymerase by molecular docking", "publicationYear": 2011, "publicationDate": "2011-06-06", "type": "journal-article", "publisher": "Biomedical Informatics", "containerTitle": "Bioinformation", "volume": "6", "issue": "6", "page": "221-225", "issn": "0973-8894, 0973-2063", "isbn": null, "authors": "Yoshinobu Ishikawa, Satoshi Fujii", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 20, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.6026/97320630006221", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1212/wnl.82.10_supplement.p1.179", "doi": "10.1212/wnl.82.10_supplement.p1.179", "title": "Amelioration of Experimental Autoimmune Encephalomyelitis by RNA Polymerase 1 Inhibitor: Molecular and Cellular Mechanisms (P1.179)", "publicationYear": 2014, "publicationDate": "2014-04-08", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Neurology", "volume": "82", "issue": "10_supplement", "page": null, "issn": "0028-3878, 1526-632X", "isbn": null, "authors": "Michael Gurevich, Rina Falb, Anat Achiron", "authorCount": 3, "firstAuthorAffiliation": "Multiple Sclerosis Center Sheba Medical Center Ramat Gan  Israel", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1212/wnl.82.10_supplement.p1.179", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1016/0378-1119(94)90022-1", "doi": "10.1016/0378-1119(94)90022-1", "title": "Human RNA polymerase II subunit hRPB14 is homologous to yeast RNA polymerase I, II, and III subunits (AC19 and RPB11) and is similar to a portion of the bacterial RNA polymerase α subunit", "publicationYear": 1994, "publicationDate": "1994-08", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gene", "volume": "145", "issue": "2", "page": "289-292", "issn": "0378-1119", "isbn": null, "authors": "Uttam K. Pati", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 27, "referenceCount": 22, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/0378-1119(94)90022-1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1016/j.bpj.2011.11.2537", "doi": "10.1016/j.bpj.2011.11.2537", "title": "Mechanism of Inhibition By, and of Drug Resistance to, a Benzimidazole Inhibitor of the RNA-Dependent RNA Polymerase of Bovine Viral Diarrhoea Virus", "publicationYear": 2012, "publicationDate": "2012-01", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Biophysical Journal", "volume": "102", "issue": "3", "page": "462a", "issn": "0006-3495", "isbn": null, "authors": "Saumya S. Pandey, Shailendra Asthana, Paolo Lacola, Attillio Vargiu, Paolo Ruggerone", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.bpj.2011.11.2537", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mf330Iekj69NdaGTN", "_dataset_id": "wpRFiGgfnaHk20RQ8"}
{"paperId": "10.1109/lra.2023.3272285/mm1", "doi": "10.1109/lra.2023.3272285/mm1", "title": "Design, Modeling and Control of a Quadruped Robot SPIDAR: Spherically Vectorable and Distributed Rotors Assisted Air-Ground Quadruped Robot_supp1-3272285.mp4", "publicationYear": 2023, "publicationDate": "2023-05-02", "type": "component", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Moju Zhao", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/lra.2023.3272285/mm1", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/icarsc.2014.6849778", "doi": "10.1109/icarsc.2014.6849778", "title": "Exploring surface detection for a quadruped robot in households", "publicationYear": 2014, "publicationDate": "2014-05", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2014 IEEE International Conference on Autonomous Robot Systems and Competitions (ICARSC)", "volume": null, "issue": null, "page": "152-157", "issn": null, "isbn": null, "authors": "Csaba Kertesz", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/icarsc.2014.6849778", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/roman.1997.646972", "doi": "10.1109/roman.1997.646972", "title": "Master-slave quadruped walking robot", "publicationYear": 2002, "publicationDate": "2002-11-22", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "Proceedings 6th IEEE International Workshop on Robot and Human Communication. RO-MAN'97 SENDAI", "volume": null, "issue": null, "page": "148-153", "issn": null, "isbn": null, "authors": "S. Aoshima, F. Sato, M. Shiraishi", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 9, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/roman.1997.646972", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/iccas.2010.5669784", "doi": "10.1109/iccas.2010.5669784", "title": "Quadruped walking robot with multi PIC microcomputer system", "publicationYear": 2010, "publicationDate": "2010-10", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "ICCAS 2010", "volume": null, "issue": null, "page": "953-956", "issn": null, "isbn": null, "authors": "Yoshihiko Takahashi, Mitsuyasu Watanabe, Shingo Tsuchiya", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/iccas.2010.5669784", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/tase.2023.3345876/mm1", "doi": "10.1109/tase.2023.3345876/mm1", "title": "Max: A Wheeled-Legged Quadruped Robot for Multimodal Agile Locomotion_supp1-3345876.mp4", "publicationYear": 2023, "publicationDate": "2023-12-29", "type": "component", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yu Zheng", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tase.2023.3345876/mm1", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/lra.2023.3272285", "doi": "10.1109/lra.2023.3272285", "title": "Design, Modeling, and Control of a Quadruped Robot SPIDAR: Spherically Vectorable and Distributed Rotors Assisted Air-Ground Quadruped Robot", "publicationYear": 2023, "publicationDate": "2023-07", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Robotics and Automation Letters", "volume": "8", "issue": "7", "page": "3923-3930", "issn": "2377-3766, 2377-3774", "isbn": null, "authors": "Moju Zhao, Tomoki Anzai, Takuzumi Nishio", "authorCount": 3, "firstAuthorAffiliation": "Department of Mechanical Engineering, The University of Tokyo, Tokyo, Japan", "isReferencedByCount": 27, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": "JSPS KAKENHI", "funderIds": null, "url": "https://doi.org/10.1109/lra.2023.3272285", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/ccdc.2010.5498555", "doi": "10.1109/ccdc.2010.5498555", "title": "Reliable gait planning for a quadruped walking robot", "publicationYear": 2010, "publicationDate": "2010-05", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2010 Chinese Control and Decision Conference", "volume": null, "issue": null, "page": "1783-1787", "issn": null, "isbn": null, "authors": "Huai Chuangfeng, Liu Pingan", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 15, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/ccdc.2010.5498555", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/robot.1996.509167", "doi": "10.1109/robot.1996.509167", "title": "Perception-based control for a quadruped walking robot", "publicationYear": 2002, "publicationDate": "2002-12-23", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "Proceedings of IEEE International Conference on Robotics and Automation", "volume": "4", "issue": null, "page": "2994-3001", "issn": null, "isbn": null, "authors": "D.J. Pack", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 13, "referenceCount": 13, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/robot.1996.509167", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/iccas.2010.5669954", "doi": "10.1109/iccas.2010.5669954", "title": "Navigation strategy for a quadruped robot on soft flat ground", "publicationYear": 2010, "publicationDate": "2010-10", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "ICCAS 2010", "volume": null, "issue": null, "page": "62-65", "issn": null, "isbn": null, "authors": "Masaaki Ikeda, Kiyotaka Izumi, Keigo Watanabe", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/iccas.2010.5669954", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/ro-man60168.2024.10731277", "doi": "10.1109/ro-man60168.2024.10731277", "title": "Learning Human-Robot Handshaking Preferences for Quadruped Robots", "publicationYear": 2024, "publicationDate": "2024-08-26", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2024 33rd IEEE International Conference on Robot and Human Interactive Communication (ROMAN)", "volume": null, "issue": null, "page": "216-223", "issn": null, "isbn": null, "authors": "Alessandra Chappuis, Guillaume Bellegarda, Auke Ijspeert", "authorCount": 3, "firstAuthorAffiliation": "Ecole Polytechnique Federale de Lausanne (EPFL),BioRobotics Laboratory", "isReferencedByCount": 2, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1109/ro-man60168.2024.10731277", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/indicon56171.2022.10039800", "doi": "10.1109/indicon56171.2022.10039800", "title": "Reinforcement Learning based Control of a Quadruped Robot", "publicationYear": 2022, "publicationDate": "2022-11-24", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2022 IEEE 19th India Council International Conference (INDICON)", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Ancy A, V R Jisha", "authorCount": 2, "firstAuthorAffiliation": "College of Engineering,Dept of ECE,Trivandrum,Trivandrum,India", "isReferencedByCount": 2, "referenceCount": 11, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/indicon56171.2022.10039800", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/icnn.1993.298516", "doi": "10.1109/icnn.1993.298516", "title": "A distributed adaptive control system for a quadruped mobile robot", "publicationYear": 2002, "publicationDate": "2002-12-30", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "IEEE International Conference on Neural Networks", "volume": null, "issue": null, "page": "144-149", "issn": null, "isbn": null, "authors": "B. Digney, M.M. Gupta", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 7, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/icnn.1993.298516", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/isr.2013.6695686", "doi": "10.1109/isr.2013.6695686", "title": "Attitude stabilization of quadruped walking robot", "publicationYear": 2013, "publicationDate": "2013-10", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "IEEE ISR 2013", "volume": null, "issue": null, "page": "1-6", "issn": null, "isbn": null, "authors": "Muhammad Ilyas, Jung San Cho, Sangdeok Park, Seung-Ho Baeg", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 13, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/isr.2013.6695686", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/access.2017.2652128", "doi": "10.1109/access.2017.2652128", "title": "Robot Simulations Based on Bipedal Spring-Mass Model With Variable Slack Length and Stiffness", "publicationYear": 2017, "publicationDate": "2017", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Access", "volume": "5", "issue": null, "page": "1156-1163", "issn": "2169-3536", "isbn": null, "authors": "Zhe Xu, Junyao Gao", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 37, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/OAPA.html", "funderNames": "National High Technology Project (863) Research and Development for Quadruped Bionic Robot in Outdoor Environment, Hydraulic Bipedal Robot Project, High Power-to-weight Ratio Quadruped Robot Research", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1109/access.2017.2652128", "pdfUrl": "https://ieeexplore.ieee.org/ielam/6287639/7859429/7814262-aam.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/carpathiancc.2019.8765958", "doi": "10.1109/carpathiancc.2019.8765958", "title": "Modeling and simulation of a parallel quadruped robot", "publicationYear": 2019, "publicationDate": "2019-05", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2019 20th International Carpathian Control Conference (ICCC)", "volume": null, "issue": null, "page": "1-5", "issn": null, "isbn": null, "authors": "Piotr Wasilewski, Justyna Tolstoj-Sienkiewicz", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 11, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/carpathiancc.2019.8765958", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
{"paperId": "10.1109/med.2014.6961591", "doi": "10.1109/med.2014.6961591", "title": "Multiobjective optimization of a quadruped robot gait", "publicationYear": 2014, "publicationDate": "2014-06", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "22nd Mediterranean Conference on Control and Automation", "volume": null, "issue": null, "page": "1520-1526", "issn": null, "isbn": null, "authors": "Edin Koco, Slaven Glumac, Zdenko Kovacic", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/med.2014.6961591", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FYykZf4oGQBXCC1eW", "_dataset_id": "ohfC5qm18JOyuIGFJ"}
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{"paperId": "10.70675/8e2266a7z34f0z4621z8133zaf62812bfe75", "doi": "10.70675/8e2266a7z34f0z4621z8133zaf62812bfe75", "title": "Graphene-based liquid-gated transistors for biosensing", "publicationYear": 2026, "publicationDate": "2026-04-04", "type": "dissertation", "publisher": "Agence Bibliographique de l'Enseignement Supérieur", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Adrien Hugo", "authorCount": 1, "firstAuthorAffiliation": "Université Grenoble Alpes", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.70675/8e2266a7z34f0z4621z8133zaf62812bfe75", "pdfUrl": null, "abstract": "Capteurs biologiques à base de transistors graphène à grille liquide Avec l'augmentation du nombre de cancers et des maladies infectieuses et cardiovasculaires, la détection précoce et/ou en temps réel des biomarqueurs associés est particulièrement cruciale afin de permettre un diagnostic et un traitement efficace. Compte tenu du vieillissement de la population mondiale, et de la nécessité de perfectionnement des services médicaux dans les pays émergents comme l'Inde ou la Chine, la demande de dispositifs de diagnostic médical représente un domaine d'application majeur pour les capteurs biologiques.Les transistors à grille liquide à base de graphène (SGFET) représentent une génération de biocapteurs très prometteuse, dans la lignée des biocapteurs à haute sensibilité s'appuyant sur les propriétés exceptionnelles des nanofils et nanotubes de carbone. Transformer un dispositif SGFET en biocapteur nécessite d'immobiliser des biorécepteurs à la surface du graphène. Les techniques de fonctionnalisation non covalente sont les plus efficaces, car elles permettent de préserver à la fois l'intégrité structurelle et les propriétés électriques du graphène. Dans cette perspective, le PBASE est largement utilisé, puisque cette molécule peut s'adsorber sur le graphène par des interactions de type pi-pi, tout en exposant un groupement chimique réactif servant d'ancrage pour le greffage de récepteurs biologiques. Cependant, il n'est pas systématiquement démontré que les biorécepteurs restent fonctionnels lorsqu'ils sont greffés au PBASE, car cette molécule est incapable d'empêcher les biorécepteurs de s'adsorber sur le graphène et d'être par conséquent dénaturés. Le \"tripod\" est une molécule se liant de manière multivalente au graphène grâce à trois pieds en pyrène, projetant efficacement toute fonctionnalité active loin de la surface, et formant une couche de reconnaissance biologique prévisible et robuste sur le graphène.Dans ce contexte, ces travaux de thèse ont visé à développer un SGFET à base de graphène fonctionnalisé avec le tripod pour des applications de détection biologique très robustes, fiables et sensibles. Différentes méthodes ont été explorées afin d'établir un procédé de fabrication stable et reproductible. Ce procédé a notamment été caractérisé par un ensemble de mesures AFM, XPS et Raman. La performance des dispositifs fabriqués a été évaluée avant la fonctionnalisation non covalente par des mesures électriques sous air et en milieu liquide, et une première preuve du concept de détection de la streptavidine a été présentée.", "subject": null, "language": null, "_run_id": "j2ba8dZL0Mj0OLXTk", "_dataset_id": "Qr89kqnZPkMYFkUUt"}
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{"paperId": "10.32388/0mcl87", "doi": "10.32388/0mcl87", "title": "Review of: \"Graphene in nMOS field-effect transistors\"", "publicationYear": 2023, "publicationDate": "2023-11-28", "type": "journal-article", "publisher": "Qeios Ltd", "containerTitle": "Qeios", "volume": null, "issue": null, "page": null, "issn": "2632-3834", "isbn": null, "authors": "Sofia Reinhard", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 19, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.32388/0mcl87", "pdfUrl": "https://www.qeios.com/read/0MCL87/pdf", "abstract": "", "subject": null, "language": null, "_run_id": "j2ba8dZL0Mj0OLXTk", "_dataset_id": "Qr89kqnZPkMYFkUUt"}
{"paperId": "10.5772/intechopen.111562", "doi": "10.5772/intechopen.111562", "title": "Graphene-Based Plasmonic Terahertz Laser Transistors", "publicationYear": 2023, "publicationDate": "2023-09-27", "type": "book-chapter", "publisher": "IntechOpen", "containerTitle": "Trends in Terahertz Technology", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9781837681679, 9781837681686", "authors": "Taiichi Otsuji", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/3.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5772/intechopen.111562", "pdfUrl": null, "abstract": "This chapter reviews recent advances in the research of graphene-based plasmonic terahertz laser transistors. Optically or electrically pumped graphene works as a gain medium in the terahertz frequency range. The author’s group theoretically discovered this fact and experimentally verified the single mode terahertz emission, as well as broadband terahertz amplified spontaneous emission from fabricated graphene-channel field-effect transistor (GFET) laser chips. However, its lasing threshold temperature was low (100 K) and emission intensity was weak. To drastically improve the laser performance, the introduction of graphene Dirac plasmons (GDPs) as the gain booster is promising. The author’s group found a novel way to promote the current-driven instability of the GDPs in an asymmetric dual-grating-gate GFET, demonstrating room-temperature amplification of stimulated emission of terahertz radiation with the maximal gain of 9% which is four times larger than the quantum-mechanical limit when terahertz photons directly interact with graphene electrons without excitation of the GDPs. The author also proposes the active controlling of the parity and time-reversal symmetries of the GDPs as a paradigm towards ultrafast direct gain switching in the GFET lasers. Future directions to unite the gain seed and amplifier sections in a single GFET structure will be addressed with several feasible scenarios.", "subject": null, "language": "en", "_run_id": "j2ba8dZL0Mj0OLXTk", "_dataset_id": "Qr89kqnZPkMYFkUUt"}
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{"paperId": "10.1021/acs.macromol.6b01011.s001", "doi": "10.1021/acs.macromol.6b01011.s001", "title": "Conformational Transitions of Polymer Brushes for Reversibly Switching Graphene Transistors", "publicationYear": 2020, "publicationDate": "2020-04-07", "type": "component", "publisher": "American Chemical Society (ACS)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/acs.macromol.6b01011.s001", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "j2ba8dZL0Mj0OLXTk", "_dataset_id": "Qr89kqnZPkMYFkUUt"}
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{"paperId": "10.1021/acsnano.9b01395.s001", "doi": "10.1021/acsnano.9b01395.s001", "title": "Graphene and Carbon Nanotube Heterojunction Transistors with Individual Gate Control", "publicationYear": 2020, "publicationDate": "2020-04-09", "type": "component", "publisher": "American Chemical Society (ACS)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/acsnano.9b01395.s001", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "j2ba8dZL0Mj0OLXTk", "_dataset_id": "Qr89kqnZPkMYFkUUt"}
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{"paperId": "10.1038/480009f", "doi": "10.1038/480009f", "title": "Stretchy graphene transistors", "publicationYear": 2011, "publicationDate": "2011-12-01", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "480", "issue": "7375", "page": "9-9", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 1, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/480009f", "pdfUrl": "https://www.nature.com/articles/480009f.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "j2ba8dZL0Mj0OLXTk", "_dataset_id": "Qr89kqnZPkMYFkUUt"}
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{"paperId": "10.1002/adma.201290171", "doi": "10.1002/adma.201290171", "title": "Lipid Nanoparticles: Peptide Targeted Lipid Nanoparticles for Anticancer Drug Delivery (Adv. Mater. 28/2012)", "publicationYear": 2012, "publicationDate": "2012-07-24", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Materials", "volume": "24", "issue": "28", "page": "3710-3710", "issn": "0935-9648, 1521-4095", "isbn": null, "authors": "Timothy R. Pearce, Kamlesh Shroff, Efrosini Kokkoli", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/adma.201290171", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadma.201290171", "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1007/s40005-015-0224-x", "doi": "10.1007/s40005-015-0224-x", "title": "Development and evaluation of lipid nanoparticles for paclitaxel delivery: a comparison between solid lipid nanoparticles and nanostructured lipid carriers", "publicationYear": 2015, "publicationDate": "2015-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Journal of Pharmaceutical Investigation", "volume": "45", "issue": "7", "page": "675-680", "issn": "2093-5552, 2093-6214", "isbn": null, "authors": "Wenting Xu, Mi-Kyung Lee", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 18, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": "National Research Foundation of Korea", "funderIds": "10.13039/501100003725", "url": "https://doi.org/10.1007/s40005-015-0224-x", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s40005-015-0224-x.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1016/j.ejpb.2008.05.008", "doi": "10.1016/j.ejpb.2008.05.008", "title": "Lipid nanoparticles as vehicles for topical psoralen delivery: Solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC)", "publicationYear": 2008, "publicationDate": "2008-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "European Journal of Pharmaceutics and Biopharmaceutics", "volume": "70", "issue": "2", "page": "633-640", "issn": "0939-6411", "isbn": null, "authors": "Jia-You Fang, Chia-Lang Fang, Chi-Hsien Liu, Yu-Han Su", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 439, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.ejpb.2008.05.008", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1002/chin.200748265", "doi": "10.1002/chin.200748265", "title": "Stability of Lipid Excipients in Solid Lipid Nanoparticles", "publicationYear": 2007, "publicationDate": "2007-11-27", "type": "journal-article", "publisher": "Wiley", "containerTitle": "ChemInform", "volume": "38", "issue": "48", "page": null, "issn": "0931-7597, 1522-2667", "isbn": null, "authors": "Anna Radomska‐Soukharev", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 1, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/chin.200748265", "pdfUrl": null, "abstract": "AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.", "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.53555/af1m3d61", "doi": "10.53555/af1m3d61", "title": "PREPARATION OF SOLID LIPID NANOPARTICLES (SLN) AND NANOSTRUCTURATED LIPID CARRIERS (NLC)", "publicationYear": 2024, "publicationDate": "2024-09-29", "type": "journal-article", "publisher": "Green Publication", "containerTitle": "Journal of Population Therapeutics and Clinical Pharmacology", "volume": null, "issue": null, "page": "187-206", "issn": null, "isbn": null, "authors": "Rabia Taj", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.53555/af1m3d61", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.21608/zjps.2010.162481", "doi": "10.21608/zjps.2010.162481", "title": "PREPARATION AND CHARACTERIZATION OF SOLID LIPID MICRO/NANOPARTICLES I. EFFECT OF LIPID CONCENTRATION, SURFACTANT TYPE AND CONCENTRATION ON PHYSICAL CHARACTERISTICS OF SOLID LIPID MICRO/NANOPARTICLES", "publicationYear": 2010, "publicationDate": "2010-12-01", "type": "journal-article", "publisher": "Egypts Presidential Specialized Council for Education and Scientific Research", "containerTitle": "Zagazig Journal of Pharmaceutical Sciences", "volume": "19", "issue": "2", "page": "1-4", "issn": "2356-9786", "isbn": null, "authors": "Ahmed Gardouh, Hussein Sayed, Mamdouh Ghorab, Shaded Abdel-Rahman", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.21608/zjps.2010.162481", "pdfUrl": "https://zjps.journals.ekb.eg/article_162481_2be68decc4d8ce4d4d10208fdae44793.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.69645/pfky1980", "doi": "10.69645/pfky1980", "title": "Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)", "publicationYear": 2023, "publicationDate": "2023-10-31", "type": "journal-article", "publisher": "Henry Stewart Talks", "containerTitle": "The Biomedical &amp; Life Sciences Collection", "volume": "2023", "issue": "10", "page": "e1005196", "issn": "2056-452X", "isbn": null, "authors": "Ana Catarina Silva", "authorCount": 1, "firstAuthorAffiliation": "University Fernando Pessoa and University of Porto", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.69645/pfky1980", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1016/j.biopha.2019.109057", "doi": "10.1016/j.biopha.2019.109057", "title": "Long-term anesthetic analgesic effects: Comparison of tetracaine loaded polymeric nanoparticles, solid lipid nanoparticles, and nanostructured lipid carriers in vitro and in vivo", "publicationYear": 2019, "publicationDate": "2019-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Biomedicine &amp; Pharmacotherapy", "volume": "117", "issue": null, "page": "109057", "issn": "0753-3322", "isbn": null, "authors": "Xiaoli Liu, Qianqian Zhao", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 21, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.biopha.2019.109057", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.3390/pharmaceutics15041184", "doi": "10.3390/pharmaceutics15041184", "title": "Key Design Features of Lipid Nanoparticles and Electrostatic Charge-Based Lipid Nanoparticle Targeting", "publicationYear": 2023, "publicationDate": "2023-04-07", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Pharmaceutics", "volume": "15", "issue": "4", "page": "1184", "issn": "1999-4923", "isbn": null, "authors": "Vijay Gyanani, Roshan Goswami", "authorCount": 2, "firstAuthorAffiliation": "T.J.L. School of Pharmacy, University of the Pacific, Stockton, CA 95211, USA", "isReferencedByCount": 35, "referenceCount": 120, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/pharmaceutics15041184", "pdfUrl": null, "abstract": "Lipid nanoparticles (LNP) have gained much attention after the approval of mRNA COVID-19 vaccines. The considerable number of currently ongoing clinical studies are testament to this fact. These efforts towards the development of LNPs warrant an insight into the fundamental developmental aspects of such systems. In this review, we discuss the key design aspects that confer efficacy to a LNP delivery system, i.e., potency, biodegradability, and immunogenicity. We also cover the underlying considerations regarding the route of administration and targeting of LNPs to hepatic and non-hepatic targets. Furthermore, since LNP efficacy is also a function of drug/nucleic acid release within endosomes, we take a holistic view of charged-based targeting approaches of LNPs not only in the context of endosomal escape but also in relation to other comparable target cell internalization strategies. Electrostatic charge-based interactions have been used in the past as a potential strategy to enhance the drug release from pH-sensitive liposomes. In this review, we cover such strategies around endosomal escape and cell internalization in low pH tumor micro-environments.", "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.2174/2211738510666220210110003", "doi": "10.2174/2211738510666220210110003", "title": "Optimized Nanoparticles for Enhanced Oral Bioavailability of a Poorly Soluble Drug: Solid Lipid Nanoparticles <i>Versus</i> Nanostructured Lipid Carriers", "publicationYear": 2022, "publicationDate": "2022-02", "type": "journal-article", "publisher": "Bentham Science Publishers Ltd.", "containerTitle": "Pharmaceutical Nanotechnology", "volume": "10", "issue": "1", "page": "69-87", "issn": "2211-7385", "isbn": null, "authors": "Manal K.M. Darwish, Amal S.M. Abu El-Enin, Kamilia H.A. Mohammed", "authorCount": 3, "firstAuthorAffiliation": "Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University (Girls), Cairo,\nEgypt", "isReferencedByCount": 13, "referenceCount": 58, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2174/2211738510666220210110003", "pdfUrl": "https://www.eurekaselect.com/article/download?doi=10.2174/2211738510666220210110003", "abstract": "Introduction: Rosuvastatin calcium (ROSCa) is an anti-hyperlipidemic drug with only 20% oral bioavailability due to its low solubility and high first-pass metabolism. Therefore, the main purpose of this work was to compare solid lipid nanoparticles to nanostructured lipid carriers and evaluate their effect on solubility improvement and hence the bioavailability of a model insoluble drug. Methodology: Different nanosuspensions were formulated using high-speed homogenization and ultrasonication techniques, using Apifil as solid lipid and Maisine as liquid lipid. The effect of different variables on quality attributes (particle size, entrapment efficiency (EE), and in vitro release) was studied using the Box-Behnken design. Then, the optimized nanoparticles were lyophilized, filled into capsules, and evaluated. Finally, the optimized formula was clinically evaluated in six healthy human volunteers. Results: It was observed that the variables had a great impact on EE and particle size. Nanoparticles showed maximum particles of 180.3 nm, and % EE ranged from 40.77% to 91.67%. Capsules loaded with NLCs were found to be more stable than those loaded with SLNs. The clinical study of NLCs-ROSCa showed an enhancement in the C max (8.92 ng/ml) compared to the commercial product (2.56 ng/ml) with approximately 349% relative bioavailability. Conclusion: ROSCa was successfully encapsulated in SLNs and NLCs. The optimized NLCs formulation showed improved quality attributes compared to SLNs. Thus, NLCs loaded formulations could be an effective oral drug delivery system to enhance the bioavailability of insoluble drugs.", "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.4333/kps.2005.35.3.143", "doi": "10.4333/kps.2005.35.3.143", "title": "Preparation and Evaluation of Sold Lipid Nanoparticles(SLNs) containing 5-Fluorouracil and Its Derivative", "publicationYear": 2005, "publicationDate": "2005-06-20", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Journal of Korean Pharmaceutical Sciences", "volume": "35", "issue": "3", "page": "143-150", "issn": "0259-2347", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 12, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4333/kps.2005.35.3.143", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1023/a-1025065418309", "doi": "10.1023/a:1025065418309", "title": "Physicochemical Investigations on Solid Lipid Nanoparticles and on Oil-Loaded Solid Lipid Nanoparticles: A Nuclear Magnetic Resonance and Electron Spin Resonance Study", "publicationYear": 2003, "publicationDate": "2003-08", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Pharmaceutical Research", "volume": "20", "issue": "8", "page": "1274-1283", "issn": "0724-8741, 1573-904X", "isbn": null, "authors": "Katja Jores, Wolfgang Mehnert, Karsten Mäder", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 159, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1023/a:1025065418309", "pdfUrl": "https://link.springer.com/content/pdf/10.1023/A:1025065418309.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.2174/156720108785915087", "doi": "10.2174/156720108785915087", "title": "Solid Lipid Nanoparticles and Nanostructured Lipid Carriers – Innovative Generations of Solid Lipid Carriers", "publicationYear": 2008, "publicationDate": "2008-10-01", "type": "journal-article", "publisher": "Bentham Science Publishers Ltd.", "containerTitle": "Current Drug Delivery", "volume": "5", "issue": "4", "page": "324-331", "issn": "1567-2018", "isbn": null, "authors": "S. Shidhaye, Reshma Vaidya, Sagar Sutar, Arati Patwardhan, V. Kadam", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 180, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2174/156720108785915087", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1016/j.addr.2007.04.004", "doi": "10.1016/j.addr.2007.04.004", "title": "Stability of lipid excipients in solid lipid nanoparticles☆", "publicationYear": 2007, "publicationDate": "2007-07-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Advanced Drug Delivery Reviews", "volume": "59", "issue": "6", "page": "411-418", "issn": "0169-409X", "isbn": null, "authors": "A RADOMSKASOUKHAREV", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 161, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.addr.2007.04.004", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.2174/157488511798109637", "doi": "10.2174/157488511798109637", "title": "Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: A Review", "publicationYear": 2011, "publicationDate": "2011-11-01", "type": "journal-article", "publisher": "Bentham Science Publishers Ltd.", "containerTitle": "Current Drug Therapy", "volume": "6", "issue": "4", "page": "240-250", "issn": "1574-8855", "isbn": null, "authors": "Rajashree Hirlekar, Harshal Garse, Vilasrao Kadam", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 14, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2174/157488511798109637", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.2174/0122117385318686241003103005", "doi": "10.2174/0122117385318686241003103005", "title": "Solid Lipid Nanoparticles and Nanostructured Lipid Particles: A Comparative Review on Lipid-based Nanocarriers", "publicationYear": 2026, "publicationDate": "2026-03", "type": "journal-article", "publisher": "Bentham Science Publishers Ltd.", "containerTitle": "Pharmaceutical Nanotechnology", "volume": "14", "issue": "2", "page": "230-246", "issn": "2211-7385", "isbn": null, "authors": "Anjali Sharma, Devkant Sharma, Pritish Kumar Panda, Niladry Shekhar Ghosh", "authorCount": 4, "firstAuthorAffiliation": "Guru Gobind Singh College of Pharmacy, Yamunanagar, 135001, Haryana, India", "isReferencedByCount": 3, "referenceCount": 156, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2174/0122117385318686241003103005", "pdfUrl": "https://www.eurekaselect.com/article/download?doi=10.2174/0122117385318686241003103005", "abstract": "Lipid-based nanocarriers have emerged as promising vehicles for the delivery of various therapeutic agents, owing to their biocompatibility, stability, and ability to encapsulate both hydrophilic and hydrophobic drugs. Among these lipid-based nanocarriers, Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) have gained significant attention in the field of drug delivery. This comparative review aims to provide a comprehensive analysis of SLNs and NLCs, focusing on their formulation, physicochemical properties, drug-loading capacity, stability, and drug release profiles. The review highlights the differences in preparation techniques, particle size, zeta potential, drug encapsulation efficiency, stability, drug delivery, cosmetic and personal care, and food industry applications between SLN and NLC. Furthermore, the review discusses the toxicity and safety profiles of these nanoparticles, including cytotoxicity, genotoxicity, acute toxicity, and long-term toxicity. Finally, the review identifies the potential applications, limitations, and future research directions of SLN and NLC. In summary, this comparative review provides valuable insights into the formulation, physicochemical properties, drug-loading capacity, stability, and drug release profiles of SLNs and NLCs. By understanding the similarities and differences between these lipid-based nanocarriers, researchers and pharmaceutical scientists can make informed decisions regarding the selection of the most suitable nanocarrier for specific therapeutic applications.", "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1016/s1525-0016(16)35588-5", "doi": "10.1016/s1525-0016(16)35588-5", "title": "575. Chitosan/siRNA Nanoparticles Demonstrate Superior Silencing Efficiency and Lower Toxicity Compared To Lipid Nanoparticles", "publicationYear": 2014, "publicationDate": "2014-05", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Molecular Therapy", "volume": "22", "issue": null, "page": "S223", "issn": "1525-0016", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s1525-0016(16)35588-5", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.2174/1381612823666171115105721", "doi": "10.2174/1381612823666171115105721", "title": "Characterization Methods for Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC)", "publicationYear": 2018, "publicationDate": "2018-02-15", "type": "journal-article", "publisher": "Bentham Science Publishers Ltd.", "containerTitle": "Current Pharmaceutical Design", "volume": "23", "issue": "43", "page": "6630-6642", "issn": "1381-6128", "isbn": null, "authors": "Velichka Andonova, Petya Peneva", "authorCount": 2, "firstAuthorAffiliation": "Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University - Plovdiv, Plovdiv 4002, Bulgaria", "isReferencedByCount": 67, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2174/1381612823666171115105721", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.21275/sr25630213206", "doi": "10.21275/sr25630213206", "title": "Targeted Gene Editing for PKD: Optimizing CRISPR / Cas9 Delivery Through Electroporation and Lipid Nanoparticles", "publicationYear": 2025, "publicationDate": "2025-07-05", "type": "journal-article", "publisher": "International Journal of Science and Research", "containerTitle": "International Journal of Science and Research (IJSR)", "volume": null, "issue": null, "page": "187-200", "issn": "2319-7064", "isbn": null, "authors": "Raksheet Reddy Gummakonda", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.21275/sr25630213206", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.61173/4hhm6b86", "doi": "10.61173/4hhm6b86", "title": "Applications of Lipid Nanoparticles in CRISPR Technology.", "publicationYear": 2024, "publicationDate": "2024-05-16", "type": "journal-article", "publisher": "Dean & Francis Press", "containerTitle": "MedScien", "volume": "1", "issue": "3", "page": null, "issn": "2960-1290", "isbn": null, "authors": "Tianhao Zhang", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.61173/4hhm6b86", "pdfUrl": "https://www.deanfrancis.press/ojs/index.php/ms/article/download/67/MS000852.pdf", "abstract": "Clustered, regularly interspaced short palindromic repeat (CRISPR) genome editing is one of the most popular gene editing techniques with its simpleness, convenience, and efficiency. Nowadays, CRISPR-Cas9 technology has been used in agriculture, medicine, biology, and many other fields for screening target genes, creating modal animals, and gene therapy. However, there are still obstacles before clinical applications of CRISPR-Cas9, and a safe and effective delivery system is required for transportation. Studies have shown that lipid-nanoparticle-based delivery, using lipid nanoparticle (LNP) as the carrier, is a good method of transportation. LNP is a vesica-like globule composed of a lipid shell adorned with signal proteins and goods inside it. LNP improved the stability and immunogenicity of the CRISPR-Cas9 system and has the merits of easy production and high modifiability, making it an ideal carrier with high potential in the future. This review introduces four basic components of LNP: localizable cationic lipids, polyethylene glycol (PEG) lipids, zwitterionic phospholipids, and cholesterol. This review focuses on the applications of LNP, including lipid-encapsulated gold nanoparticles, biocompatible monosized lipid-coated stellate mesoporous silica nanoparticles (LC-MSNs), biodegradable lipid and messenger RNA Nanoparticles, Mulberry leaf lipid nanoparticles, phenylboronic acid-derived lipid nanoparticles, lipid-polymer hybrid nanoparticles combined with ultrasound-mediated microbubble destruction, cationic lipid-assisted PEG-b-PLGA nanoparticles, multi-valent N-Acetylgalactosamine-Lipid nanoparticles, etc. Further research in LNP and CRISPR systems is required to optimize the delivery properties for clinical applications.", "subject": null, "language": null, "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.2174/1389200220666191112145808", "doi": "10.2174/1389200220666191112145808", "title": "Pharmacokinetic Evaluation of <sup>99m</sup>Tc-radiolabeled Solid Lipid Nanoparticles and Chitosan Coated Solid Lipid Nanoparticles", "publicationYear": 2020, "publicationDate": "2020-01-23", "type": "journal-article", "publisher": "Bentham Science Publishers Ltd.", "containerTitle": "Current Drug Metabolism", "volume": "20", "issue": "13", "page": "1044-1052", "issn": "1389-2002", "isbn": null, "authors": "Nasrin Abbasi Gharibkandi, Sajjad Molavipordanjani, Jafar Akbari, Seyed Jalal Hosseinimehr", "authorCount": 4, "firstAuthorAffiliation": "Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran", "isReferencedByCount": 3, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": null, "funderNames": "Mazandaran University of Medical Sciences", "funderIds": "10.13039/501100004160", "url": "https://doi.org/10.2174/1389200220666191112145808", "pdfUrl": null, "abstract": "Background: Solid Lipid Nanoparticles (SLNs) possess unique in vivo features such as high resistivity, bioavailability, and habitation at the target site. Coating nanoparticles with polymers such as chitosan greatly affects their pharmacokinetic behavior, stability, tissue uptake, and controlled drug delivery. The aim of this study was to prepare and evaluate the biodistribution of 99mTc-labeled SLNs and chitosan modified SLNs in mice. Methods: 99mTc-oxine was prepared and utilized to radiolabel pre-papered SLNs or chitosan coated SLNs. After purification of radiolabeled SLNs (99mTc-SLNs) and radiolabeled chitosan-coated SLNs (99mTc-Chi-SLNs) using Amicon filter, they were injected into BALB/c mice to evaluate their biodistribution patterns. In addition, nanoparticles were characterized using Transmission Electron Microscopy (TEM), Fourier-transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), X-ray Powder Diffraction (XRD) and Dynamic Light Scattering (DLS). Results: 99mTc-oxine with high radiochemical purity (RCP~100%) and stability (RCP &gt; 97% at 24 h) was used to provide 99mTc-SLNs and 99mTc-Chi-SLNs with high initial RCP (100%). TEM image and DLS data suggest 99mTc- SLNs susceptibility to aggregation. To that end, the main portion of 99mTc-SLNs radioactivity accumulates in the liver and intestines, while 99mTc-Chi-SLNs sequesters in the liver, intestines and kidneys. The blood radioactivity of 99mTc-Chi-SLNs was higher than that of 99mTc-SLNs by 7.5, 3.17 and 3.5 folds at 1, 4 and 8 h post-injection. 99mTc- Chi-SLNs uptake in the kidneys in comparison with 99mTc-SLNs was higher by 37.48, 5.84 and 11 folds at 1, 4 and 8h. Conclusion: The chitosan layer on the surface of 99mTc-Chi-SLNs reduces lipophilicity in comparison with 99mTc- SLNs. Therefore, 99mTc-Chi-SLNs are less susceptible to aggregation, which leads to their lower liver uptake and higher kidney uptake and blood concentration.", "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1021/acs.molpharmaceut.3c00547", "doi": "10.1021/acs.molpharmaceut.3c00547", "title": "Differences and Similarities of the Intravenously Administered Lipid Nanoparticles in Three Clinical Trials: Potential Linkage between Lipid Nanoparticles and Extracellular Vesicles", "publicationYear": 2023, "publicationDate": "2023-10-02", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Molecular Pharmaceutics", "volume": "20", "issue": "10", "page": "4883-4892", "issn": "1543-8384, 1543-8392", "isbn": null, "authors": "Yuta Suzuki, Yuri Katsurada, Kenji Hyodo", "authorCount": 3, "firstAuthorAffiliation": "Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan", "isReferencedByCount": 22, "referenceCount": 82, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/acs.molpharmaceut.3c00547", "pdfUrl": "https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.3c00547", "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.3390/ph16030474", "doi": "10.3390/ph16030474", "title": "Recent Progress of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Ocular Drug Delivery Platforms", "publicationYear": 2023, "publicationDate": "2023-03-22", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Pharmaceuticals", "volume": "16", "issue": "3", "page": "474", "issn": "1424-8247", "isbn": null, "authors": "Viliana Gugleva, Velichka Andonova", "authorCount": 2, "firstAuthorAffiliation": "Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria", "isReferencedByCount": 69, "referenceCount": 215, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/ph16030474", "pdfUrl": null, "abstract": "Sufficient ocular bioavailability is often considered a challenge by the researchers, due to the complex structure of the eye and its protective physiological mechanisms. In addition, the low viscosity of the eye drops and the resulting short ocular residence time further contribute to the observed low drug concentration at the target site. Therefore, various drug delivery platforms are being developed to enhance ocular bioavailability, provide controlled and sustained drug release, reduce the number of applications, and maximize therapy outcomes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) exhibit all these benefits, in addition to being biocompatible, biodegradable, and susceptible to sterilization and scale-up. Furthermore, their successive surface modification contributes to prolonged ocular residence time (by adding cationic compounds), enhanced penetration, and improved performance. The review highlights the salient characteristics of SLNs and NLCs concerning ocular drug delivery, and updates the research progress in this area.", "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1208/s12249-018-1229-3", "doi": "10.1208/s12249-018-1229-3", "title": "Drug-Lipid-Surfactant Miscibility for the Development of Solid Lipid Nanoparticles", "publicationYear": 2019, "publicationDate": "2019-02", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "AAPS PharmSciTech", "volume": "20", "issue": "2", "page": null, "issn": "1530-9932", "isbn": null, "authors": "Anne Trivino, Ashwini Gumireddy, Harsh Chauhan", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 16, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1208/s12249-018-1229-3", "pdfUrl": "http://link.springer.com/content/pdf/10.1208/s12249-018-1229-3.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1002/chin.200502271", "doi": "10.1002/chin.200502271", "title": "Physical Chemical Considerations of Lipid‐Based Oral Drug Delivery‐Solid Lipid Nanoparticles", "publicationYear": 2005, "publicationDate": "2005-01-11", "type": "journal-article", "publisher": "Wiley", "containerTitle": "ChemInform", "volume": "36", "issue": "2", "page": null, "issn": "0931-7597, 1522-2667", "isbn": null, "authors": "Paul M. Bummer", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 1, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/chin.200502271", "pdfUrl": null, "abstract": "AbstractFor Abstract see ChemInform Abstract in Full Text.", "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1016/j.bpj.2019.11.2207", "doi": "10.1016/j.bpj.2019.11.2207", "title": "The Role of Lipid Structure Indisruption of Lipid Membranes by Silica Nanoparticles", "publicationYear": 2020, "publicationDate": "2020-02", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Biophysical Journal", "volume": "118", "issue": "3", "page": "387a", "issn": "0006-3495", "isbn": null, "authors": "Saeed Nazemidashtarjandi, Amir Farnoud", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.bpj.2019.11.2207", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.2174/0113816128319233240725103706", "doi": "10.2174/0113816128319233240725103706", "title": "Advancements in Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Breast Cancer Therapy", "publicationYear": 2024, "publicationDate": "2024-10", "type": "journal-article", "publisher": "Bentham Science Publishers Ltd.", "containerTitle": "Current Pharmaceutical Design", "volume": "30", "issue": "37", "page": "2922-2936", "issn": "1381-6128", "isbn": null, "authors": "Harneet Marwah, Hitesh Kumar Dewangan", "authorCount": 2, "firstAuthorAffiliation": "University Institute of Pharma Sciences (UIPS), Chandigarh University, NH-95 Chandigarh Ludhiana Highway, Mohali, Punjab,\nIndia", "isReferencedByCount": 21, "referenceCount": 102, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2174/0113816128319233240725103706", "pdfUrl": "https://www.eurekaselect.com/article/download?doi=10.2174/0113816128319233240725103706", "abstract": ": Solid Lipid Nanocarriers (SLNs) offer a promising avenue for breast cancer treatment, a disease that accounts for 12.5% of global cancer cases. Despite strides in combined therapies (surgery, chemotherapy, radiation, and endocrine therapy), challenges like systemic toxicity, drug resistance, and adverse effects persist. The manuscript offers several novel contributions to the field of breast cancer treatment through the use of SLNs, and these are innovative drug delivery systems, multifunctionality, and biocompatibility, the potential to overcome drug resistance, integration with emerging therapies, focus on personalized medicine, ongoing and future research directions and potential for reduced side effects. SLNs present a novel strategy due to their unique physicochemical properties. They can encapsulate both hydrophilic and hydrophobic drugs, ensuring controlled release and targeted delivery, thus enhancing solubility and bioavailability and reducing side effects. The multifunctional nature of SLNs improves drug delivery while their biocompatibility supports their potential in cancer therapy. Challenges for pharmacists include maintaining stability, effective drug loading, and timed delivery. Combining SLNs with emerging therapies like gene and immunotherapy holds promise for more effective breast cancer treatments. SLNs represent a significant advancement, providing precise drug delivery and fewer side effects, with the potential for overcoming drug resistance. Ongoing research will refine SLNs for breast cancer therapy, targeting cells with minimal side effects and integrating with other treatments for comprehensive approaches. Advances in nanotechnology and personalized medicine will tailor SLNs to specific breast cancer subtypes, enhancing effectiveness. Clinical trials and new treatment developments are crucial for realizing SLNs’ full potential in breast cancer care. In conclusion, SLNs offer a transformative approach to breast cancer treatment, addressing issues of drug delivery and side effects. Ongoing research aims to optimize SLNs for targeted therapy, potentially revolutionizing breast cancer care and providing hope for patients.", "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.54085/ap.2022.11.2.85", "doi": "10.54085/ap.2022.11.2.85", "title": "Ranolazine loaded solid lipid nanoparticles for oral delivery: Characterization, pharmacokinetic and pharmacodynamic evaluation", "publicationYear": 2022, "publicationDate": "2022-12", "type": "journal-article", "publisher": "Ukaaz Publications", "containerTitle": "Annals of Phytomedicine: An International Journal", "volume": "11", "issue": "2", "page": null, "issn": "2278-9839, 2393-9885", "isbn": null, "authors": "Abdul Sayeed Khan, Bhupen Chandra Behera", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.54085/ap.2022.11.2.85", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1088/0957-4484/25/10/105101", "doi": "10.1088/0957-4484/25/10/105101", "title": "Sucrose ester stabilized solid lipid nanoparticles and nanostructured lipid carriers: I. Effect of formulation variables on the physicochemical properties, drug release and stability of clotrimazole-loaded nanoparticles", "publicationYear": 2014, "publicationDate": "2014-03-14", "type": "journal-article", "publisher": "IOP Publishing", "containerTitle": "Nanotechnology", "volume": "25", "issue": "10", "page": "105101", "issn": "0957-4484, 1361-6528", "isbn": null, "authors": "Surajit Das, Wai Kiong Ng, Reginald B H Tan", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 31, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": "http://iopscience.iop.org/info/page/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1088/0957-4484/25/10/105101", "pdfUrl": "http://stacks.iop.org/0957-4484/25/i=10/a=105101/pdf", "abstract": null, "subject": null, "language": null, "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.47583/ijpsrr.2023.v83i01.006", "doi": "10.47583/ijpsrr.2023.v83i01.006", "title": "Solid Lipid Nanoparticles (SLNs): A Novel Formulation in Drug Delivery System", "publicationYear": 2023, "publicationDate": "2023-12", "type": "journal-article", "publisher": "Global Research Online", "containerTitle": "International Journal of Pharmaceutical Sciences Review and Research", "volume": "83", "issue": "1", "page": null, "issn": "0976-044X", "isbn": null, "authors": "Shikha Upadhyay, Dr Govind Soni", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.47583/ijpsrr.2023.v83i01.006", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1007/s11094-019-02017-9", "doi": "10.1007/s11094-019-02017-9", "title": "Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Emerging Lipid Based Drug Delivery Systems", "publicationYear": 2019, "publicationDate": "2019-08", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Pharmaceutical Chemistry Journal", "volume": "53", "issue": "5", "page": "440-453", "issn": "0091-150X, 1573-9031", "isbn": null, "authors": "Rupesh K. Shirodkar, Lalit Kumar, Srinivas Mutalik, Shaila Lewis", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 106, "referenceCount": 153, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s11094-019-02017-9", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s11094-019-02017-9.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.25258/ijddt.14.2.90", "doi": "10.25258/ijddt.14.2.90", "title": "Solid lipid Nanoparticles and Nanostructured Lipid Carrier: A Novel Approach for Lipid-Based Drug Delivery System", "publicationYear": 2024, "publicationDate": "2024-06-24", "type": "journal-article", "publisher": "Dr. Yashwant Research Labs Pvt. Ltd.", "containerTitle": "INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY", "volume": "14", "issue": "02", "page": "1232-1238", "issn": "0975-4415", "isbn": null, "authors": "Naimish Nanda, Chozharajan Tharmaraj, Saswati Panigrahi, Mandadi Sandhya Rani", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.25258/ijddt.14.2.90", "pdfUrl": null, "abstract": "Lipid nanoparticles, or LNPs, including nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs), attracted a lot of attention lately. SLNs were formed to circumvent the confines of the most common colloidal carriers because of their benefits, which include a favorable profile of release and precise administration of the drug with great physical stability. NLCs are the succeeding group of lipid nanoparticles with better capacity loading and durability. There are three possible NLC structural models. These LNPs may find usage in clinical medicine, research, cosmetics, and drug delivery.", "subject": null, "language": null, "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1002/chin.200527273", "doi": "10.1002/chin.200527273", "title": "Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) in Cosmetic and Dermatological Preparations", "publicationYear": 2005, "publicationDate": "2005-07-05", "type": "journal-article", "publisher": "Wiley", "containerTitle": "ChemInform", "volume": "36", "issue": "27", "page": null, "issn": "0931-7597, 1522-2667", "isbn": null, "authors": "R. H. Muller", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 1, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/chin.200527273", "pdfUrl": null, "abstract": "AbstractFor Abstract see ChemInform Abstract in Full Text.", "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.2147/ijn.s25825", "doi": "10.2147/ijn.s25825", "title": "Fabrication, appraisal, and transdermal permeation of sildenafil citrate-loaded nanostructured lipid carriers versus solid lipid nanoparticles", "publicationYear": 2011, "publicationDate": "2011-12", "type": "journal-article", "publisher": "Informa UK Limited", "containerTitle": "International Journal of Nanomedicine", "volume": null, "issue": null, "page": "3195", "issn": "1178-2013", "isbn": null, "authors": "Yosra Elnaggar, El-Massik, Abdallah", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 78, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/3.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2147/ijn.s25825", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.2174/1381612823666171122111132", "doi": "10.2174/1381612823666171122111132", "title": "Effective Delivery Routes and Strategies for Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC)", "publicationYear": 2018, "publicationDate": "2018-02-15", "type": "journal-article", "publisher": "Bentham Science Publishers Ltd.", "containerTitle": "Current Pharmaceutical Design", "volume": "23", "issue": "43", "page": "6592-6601", "issn": "1381-6128", "isbn": null, "authors": "Divyesh H. Shastri", "authorCount": 1, "firstAuthorAffiliation": "Department of Pharmaceutics & Pharmaceutical Technology, K. B. Institute of Pharmaceutical Education & Research, Kadi Sarva Vishwavidyalaya, Gandhinagar, Gujarat, India", "isReferencedByCount": 19, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2174/1381612823666171122111132", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1208/s12249-013-0056-9", "doi": "10.1208/s12249-013-0056-9", "title": "Lipid Effects on Expulsion Rate of Amphotericin B from Solid Lipid Nanoparticles", "publicationYear": 2014, "publicationDate": "2014-04", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "AAPS PharmSciTech", "volume": "15", "issue": "2", "page": "287-295", "issn": "1530-9932", "isbn": null, "authors": "See Wei Tan, Nashiru Billa", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 29, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1208/s12249-013-0056-9", "pdfUrl": "http://link.springer.com/content/pdf/10.1208/s12249-013-0056-9.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1038/nindia.2016.63", "doi": "10.1038/nindia.2016.63", "title": "Lipid nanoparticles ferry anticancer drug to brain tumour cells", "publicationYear": 2016, "publicationDate": "2016-05-18", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature India", "volume": null, "issue": null, "page": null, "issn": "1755-3180", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nindia.2016.63", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.31838/ijpr/2020.12.01.407", "doi": "10.31838/ijpr/2020.12.01.407", "title": "Enhanced Antifungal Activity of Voriconazole-Loaded Solid Lipid Nanoparticles and Nanostructured Lipid Carriers Against Aspergillus Flavus Isolates from Goat", "publicationYear": 2020, "publicationDate": "2020-12-02", "type": "journal-article", "publisher": "SynthesisHub Advance Scientific Research", "containerTitle": "International Journal of Pharmaceutical Research", "volume": "12", "issue": "01", "page": null, "issn": "0975-2366", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.31838/ijpr/2020.12.01.407", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.11159/ijtan.2023.001", "doi": "10.11159/ijtan.2023.001", "title": "Development and Evaluation of Lipid-Based Formulations for Liver Cancer: A Comparative Study of Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers", "publicationYear": 2023, "publicationDate": "2023", "type": "journal-article", "publisher": "Avestia Publishing", "containerTitle": "International Journal of Theoretical and Applied Nanotechnology", "volume": "11", "issue": null, "page": null, "issn": "1929-1248", "isbn": null, "authors": "Mina Gayed, Dina M. Gaber, Nabila Borae", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 13, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.11159/ijtan.2023.001", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.17756/nwj.2023-s3-098", "doi": "10.17756/nwj.2023-s3-098", "title": "Formulation and Evaluation of Chitosan Based Sofosbuvir Solid Lipid Nanoparticles", "publicationYear": 2023, "publicationDate": "2023-10-20", "type": "journal-article", "publisher": "United Scientific Group", "containerTitle": "NanoWorld Journal", "volume": "9", "issue": null, "page": null, "issn": "2379-1101", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.17756/nwj.2023-s3-098", "pdfUrl": "https://jnanoworld.com/articles/v9s3/nwj-s3-shanmugam-ramaswamy.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1007/s12668-025-02277-8", "doi": "10.1007/s12668-025-02277-8", "title": "Compatibility Study of Phyto Bioactive Compound with Lipid Excipients for the Development of Solid Lipid Nanoparticles", "publicationYear": 2026, "publicationDate": "2026-01", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BioNanoScience", "volume": "16", "issue": "1", "page": null, "issn": "2191-1630, 2191-1649", "isbn": null, "authors": "Pavithra Kothapalli, Manimaran Vasanthan", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s12668-025-02277-8", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s12668-025-02277-8.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.52547/nanomicrob.2022.1.3", "doi": "10.52547/nanomicrob.2022.1.3", "title": "Lipid nanoparticles and mRNA vaccines", "publicationYear": 2022, "publicationDate": "2022-11-01", "type": "journal-article", "publisher": "CMV Verlag", "containerTitle": "NanoMicrobiology and NanoBiotechnology", "volume": "2022", "issue": "1", "page": "16-24", "issn": "2821-2479", "isbn": null, "authors": "Sedigheh Nakhaee", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.52547/nanomicrob.2022.1.3", "pdfUrl": "https://nanomicrobiology.com/covid-19-pandemic", "abstract": null, "subject": null, "language": "en", "_run_id": "2zlHKQx1bYa6dc4oh", "_dataset_id": "OL1JI8dTvIsWhYByA"}
{"paperId": "10.1017/gmb.2022.10", "doi": "10.1017/gmb.2022.10", "title": "Gut physiology meets microbiome science", "publicationYear": 2023, "publicationDate": "2023", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Gut Microbiome", "volume": "4", "issue": null, "page": null, "issn": "2632-2897", "isbn": null, "authors": "Hannelore Daniel", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 86, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/gmb.2022.10", "pdfUrl": null, "abstract": "Abstract Research on the gut microbiome has gained high popularity and almost every disease has meanwhile been linked to alterations in microbiome composition. Typically assessed via stool samples, the microbiome displays a huge diversity with a multitude of environmental parameters already identified as contributing to its character. Despite impressive scientific progress, normal microbiome diversity remains largely unexplained and it is tempting to speculate some of the yet unexplained variance is hidden in normal gut physiology. Although a few genome/phenome-wide associations studies have recently highlighted physiological parameters such as stool frequency, known as contributing to microbiome diversity, there is a large knowledge base from decades of basic research on gut functions that can be explored for possible links to stool features and microbiome characteristics. And, when extrapolating findings from faecal samples to the biology in the intestinal lumen or the mucosal microenvironment, gut anatomy and physiology features need to be considered. Similarly, differences in anatomy and physiology between rodents and humans need attention when discussing findings in animals in relation to human physiology and nutrition.", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/j.gmh.2025.100001", "doi": "10.1016/j.gmh.2025.100001", "title": "Gut Microbiome and Health: A new forum for integrative microbiome research and its impact on human health", "publicationYear": 2026, "publicationDate": "2026-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gut Microbiome and Health", "volume": "1", "issue": null, "page": "100001", "issn": "3117-3594", "isbn": null, "authors": "Ravinder Nagpal", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.gmh.2025.100001", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1155/2022/9894812", "doi": "10.1155/2022/9894812", "title": "Gut Microbiome: The Cornerstone of Life and Health", "publicationYear": 2022, "publicationDate": "2022-04-26", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Gut &amp; Microbiome Research", "volume": "2022", "issue": null, "page": "1-3", "issn": "2755-1652", "isbn": null, "authors": "Zongxin Ling, Hang Xiao, Wei Chen", "authorCount": 3, "firstAuthorAffiliation": "Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China", "isReferencedByCount": 42, "referenceCount": 11, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1155/2022/9894812", "pdfUrl": "http://downloads.hindawi.com/journals/agmr/2022/9894812.pdf", "abstract": "", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1155/agm3.v2024.1", "doi": "10.1155/agm3.v2024.1", "title": null, "publicationYear": 2024, "publicationDate": "2024-01", "type": "journal-issue", "publisher": "Wiley", "containerTitle": "Advanced Gut &amp; Microbiome Research", "volume": "2024", "issue": "1", "page": null, "issn": "2755-1652, 2755-1652", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1155/agm3.v2024.1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1155/agm3.v2025.1", "doi": "10.1155/agm3.v2025.1", "title": null, "publicationYear": 2025, "publicationDate": "2025-01", "type": "journal-issue", "publisher": "Wiley", "containerTitle": "Advanced Gut &amp; Microbiome Research", "volume": "2025", "issue": "1", "page": null, "issn": "2755-1652, 2755-1652", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1155/agm3.v2025.1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1155/agm3.v2026.1", "doi": "10.1155/agm3.v2026.1", "title": null, "publicationYear": 2026, "publicationDate": "2026-01", "type": "journal-issue", "publisher": "Wiley", "containerTitle": "Advanced Gut &amp; Microbiome Research", "volume": "2026", "issue": "1", "page": null, "issn": "2755-1652, 2755-1652", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1155/agm3.v2026.1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/b978-0-323-91313-3.00015-5", "doi": "10.1016/b978-0-323-91313-3.00015-5", "title": "Role of gut microbiome in obesity", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "Human-Gut Microbiome", "volume": null, "issue": null, "page": "95-106", "issn": null, "isbn": "9780323913133", "authors": "Uday S. Annapure, Pratisha Nair", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-323-91313-3.00015-5", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/b978-0-323-91313-3.00013-1", "doi": "10.1016/b978-0-323-91313-3.00013-1", "title": "Relationship between gut microbiome and diabetes", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "Human-Gut Microbiome", "volume": null, "issue": null, "page": "107-125", "issn": null, "isbn": "9780323913133", "authors": "Uday S. Annapure, Aaditi Bagul", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-323-91313-3.00013-1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.70034/ppp/bk/2026gcm.8", "doi": "10.70034/ppp/bk/2026gcm.8", "title": "Chapter 5 The Role of Diet in Shaping the Gut Microbiome", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Pinkpetals publication", "containerTitle": "The Gut-Brain Connection: How Your Microbiome Affects Mental Health", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9789394156333", "authors": "Dr. Rajesh Ranjan, Dr. Rohit Mishra, Dr. Aishwarya Singh", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.70034/ppp/bk/2026gcm.8", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1155/2022/9976555", "doi": "10.1155/2022/9976555", "title": "Potential Biotics for Nutritional Improvement of Health via Microbiome-Gut-Brain Axis", "publicationYear": 2022, "publicationDate": "2022-11-24", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Gut &amp; Microbiome Research", "volume": "2022", "issue": null, "page": "1-16", "issn": "2755-1652", "isbn": null, "authors": "Madiha Khan Niazi, Farooq Hassan", "authorCount": 2, "firstAuthorAffiliation": "University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Pakistan", "isReferencedByCount": 5, "referenceCount": 146, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1155/2022/9976555", "pdfUrl": "http://downloads.hindawi.com/journals/agmr/2022/9976555.pdf", "abstract": "People’s dietary consumption is significantly influenced by biological, social, and psychological behaviours; as a result, complexes regarding their health arise. Due to the nutraceutical advantages of functional foods and supplements, a variety of fermented foods and beverages are now available to consumers. The properties of probiotics, prebiotics, postbiotics, and paraprobiotics are discussed in this overview along with their importance to diet and long-term health. Several synbiotic products, which are complimentary blends of chosen, defined probiotic cultures and prebiotic substrates, have drawn consumers’ attention in the nutraceutical sector recently. Probiotics and symbiotic preparations are distinct from the traditional fermented foods eaten in various cultures, even if they might be thought of as possible biotics in food. Because they are prepared with seasonal raw ingredients obtained from regional agricultural techniques, fermented foods are affordable and a staple diet component in many nations. All of the biotics mentioned in this article are meant to increase the number of good microbes in the gut, which has been shown to be crucial for the microbiome-gut-brain axis, which affects the activity of the vagus nerve.", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/b978-0-323-91313-3.00009-x", "doi": "10.1016/b978-0-323-91313-3.00009-x", "title": "Human gut microbiome and psychological disorders", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "Human-Gut Microbiome", "volume": null, "issue": null, "page": "285-302", "issn": null, "isbn": "9780323913133", "authors": "Mudassir Azeez Khan, Sunmathi Dhandapani, B.M. Snehalatha", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-323-91313-3.00009-x", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/b978-0-323-91313-3.00014-3", "doi": "10.1016/b978-0-323-91313-3.00014-3", "title": "An introduction to human gut microbiome", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "Human-Gut Microbiome", "volume": null, "issue": null, "page": "3-14", "issn": null, "isbn": "9780323913133", "authors": "Sampan Attri, Saurabh Bansal, Gunjan Goel", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-323-91313-3.00014-3", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1155/agm3/9002193", "doi": "10.1155/agm3/9002193", "title": "Gut Microbiome Variability in Pediatric Patients With Inflammatory Bowel Disease", "publicationYear": 2025, "publicationDate": "2025-01", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Gut &amp; Microbiome Research", "volume": "2025", "issue": "1", "page": null, "issn": "2755-1652, 2755-1652", "isbn": null, "authors": "Katerina Maeder, Mytien Nguyen", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1155/agm3/9002193", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1155/agm3/9002193", "abstract": "The gut microbiome is more than just the gastrointestinal tract and the digestive organ. It is a unique community of microbes, the particular composition of which may play an important role in the development of disease, including inflammatory bowel disease (IBD). Research to date has focused on the role that genetics, the immune system, and environmental conditions may play in IBD, but additional investigations are needed to fully understand the connection between gut microbiota and the development of the disease. To illuminate this connection, data were analyzed from the Integrative Human Microbiome Project from children with Crohn′s disease (CD), and these data were compared to comparable data from healthy children. Data samples were analyzed through statistical analyses including the Welch t ‐test and PERMANOVA test. Significant differences in the composition of the gut microbial communities were observed between individuals with IBD and the control group. Specifically, samples with IBD had an increased abundance o f Escherichia coli and Ruminococcus torques. Additionally, increased levels of Bacteroides fragilis were observed, indicating that elevated levels of Bacteroides fragilis , associated with the Bacteroides fragilis toxin, may have a potential role in the onset of IBD. Furthermore, CD samples exhibited decreased Chao1 richness when compared with healthy control samples. These findings signify a potential connection between the gut microbiome and the abundance of certain microbiota with IBD onset. This paper is aimed at identifying potential connections associated with the presence of specific microbiota in the gut microbiome and the manifestation of chronic disease, particularly IBD.", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.17504/protocols.io.8epv5jk26l1b/v1", "doi": "10.17504/protocols.io.8epv5jk26l1b/v1", "title": "GUT MICROBIOME QUESTIONNAIRE v1", "publicationYear": 2023, "publicationDate": "2023-03-10", "type": "posted-content", "publisher": "Springer Science and Business Media LLC", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.17504/protocols.io.8epv5jk26l1b/v1", "pdfUrl": null, "abstract": "The protocol details the gut microbiome questionnaire_self adminsitered by subjects.", "subject": null, "language": null, "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1017/gmb.2024.13", "doi": "10.1017/gmb.2024.13", "title": "Has the two decades of research on the gut microbiome resulted in making healthier choices?", "publicationYear": 2024, "publicationDate": "2024", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Gut Microbiome", "volume": "5", "issue": null, "page": null, "issn": "2632-2897", "isbn": null, "authors": "M. Andrea Azcarate-Peril", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 73, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/gmb.2024.13", "pdfUrl": null, "abstract": "Abstract The gut microbiome is widely recognized for its significant contribution to maintaining human health across all life stages, from infancy to adulthood and beyond. This perspective article focuses on the impacts of well-supported microbiome research on global caesarean delivery rates, breastfeeding practices, and antimicrobial use. The article also explores the impact of dietary choices, particularly those involving ultra-processed foods, on the gut microbiota and their potential contribution to conditions like obesity, metabolic syndrome, and inflammatory diseases. This perspective aims to emphasize the need for updated guidelines and policy interventions to address the increasing global trends of caesarean deliveries, reduced breastfeeding, overuse of antibiotics, and consumption of highly processed foods to counter their adverse effects on gut health.", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1201/9781003489221-8", "doi": "10.1201/9781003489221-8", "title": "Bisphenols and the Gut Microbiome", "publicationYear": 2025, "publicationDate": "2025-02-10", "type": "book-chapter", "publisher": "CRC Press", "containerTitle": "Gut Microbiome and Environmental Toxicants", "volume": null, "issue": null, "page": "161-182", "issn": null, "isbn": "9781003489221", "authors": "Abida Khan, Mohd Imran", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1201/9781003489221-8", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1017/gmb.2026.10024", "doi": "10.1017/gmb.2026.10024", "title": "Evaluating the gut microbiome, dietary patterns, and cognition: a sub-study protocol from the brain health and the gut microbiome study in cognitive decline (bMicrobiome study)", "publicationYear": 2026, "publicationDate": "2026", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Gut Microbiome", "volume": "7", "issue": null, "page": null, "issn": "2632-2897", "isbn": null, "authors": "Karol Suchowiecki, Patrick G. Corr, Aidan Schurr, Aryan Asemani, Leigh A. Frame", "authorCount": 5, "firstAuthorAffiliation": "University of Connecticut Health Center", "isReferencedByCount": 0, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/gmb.2026.10024", "pdfUrl": null, "abstract": "Abstract The aim of this study is to describe the development and implementation of a novel Readiness to Change Nutritional Habits (RCNH) survey for use along with dietary assessment and gut microbiome profiling in a proof-of-concept study in individuals with early Alzheimer’s disease dementia (eAD), mild cognitive impairment (MCI), and healthy controls (HC). Overall, this methods paper contributes to emerging research examining how behavioural readiness for change can be integrated with dietary assessment and gut microbiome profiling to better understand the microbiome’s influence on the nervous system. This is a sub-study embedded within a multi-prong proof-of-concept, observational study mapping the gut microbiome in 45 participants (15 HC, 15 MCI, 15 eAD) at baseline, 3 months, and 6 months. The parent study collects gut microbiome profiles, dietary patterns, and cognitive assessments. The sub-study develops and administers the 32-item RCNH survey to characterize participants’ readiness to adopt nutritional change. This manuscript reports the RCNH survey, its development process, the sub-study protocol including data collection procedures, and planned exploratory analyses. This protocol presents a novel intervention to assess the gut microbiome, individual dietary patterns, and readiness to make lifestyle changes related to diet.", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.70034/ppp/bk/2026gcm.14", "doi": "10.70034/ppp/bk/2026gcm.14", "title": "Chapter 11 Maternal Gut Microbiome- Role in Maternal and Fetal Mental Health", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Pinkpetals publication", "containerTitle": "The Gut-Brain Connection: How Your Microbiome Affects Mental Health", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9789394156333", "authors": "Dr. Rajesh Ranjan, Dr. Rohit Mishra, Dr. Aishwarya Singh", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.70034/ppp/bk/2026gcm.14", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.55277/researchhub.q2czi9xd", "doi": "10.55277/researchhub.q2czi9xd", "title": "Gut Microbiome", "publicationYear": 2026, "publicationDate": "2026-04-23", "type": "report", "publisher": "ResearchHub Technologies, Inc.", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Ellie Amirova", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.55277/researchhub.q2czi9xd", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/j.gmh.2026.100003", "doi": "10.1016/j.gmh.2026.100003", "title": "Gut microbial strain improvement through genetic and metabolic engineering", "publicationYear": 2026, "publicationDate": "2026-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Gut Microbiome and Health", "volume": "1", "issue": null, "page": "100003", "issn": "3117-3594", "isbn": null, "authors": "Priyankar Dey", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 82, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Indian Council of Medical Research", "funderIds": "10.13039/501100001411", "url": "https://doi.org/10.1016/j.gmh.2026.100003", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1155/2024/6707728", "doi": "10.1155/2024/6707728", "title": "Gut Microbiome: An Intersection between Human Genome, Diet, and Epigenetics", "publicationYear": 2024, "publicationDate": "2024-01-09", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Gut &amp; Microbiome Research", "volume": "2024", "issue": null, "page": "1-17", "issn": "2755-1652", "isbn": null, "authors": "Abdullahi Y. Muhammad, Malik Amonov, Atif A. Baig, Farrukh J. Alvi", "authorCount": 4, "firstAuthorAffiliation": "Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, Malaysia", "isReferencedByCount": 6, "referenceCount": 173, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1155/2024/6707728", "pdfUrl": "http://downloads.hindawi.com/journals/agmr/2024/6707728.pdf", "abstract": "The composition and diversity of gut microbiome are in crosstalk with the genetic makeup and diet of an individual. Under normal health conditions, the gut commensals are in homeostasis with the host; while they inhabit the gut for their normal growth, they protect against invading pathogens through anticolonization mechanisms and contribute largely to the metabolism of several macromolecules in the gut. Specific genetic variants in genes that are responsible for maintaining the composition of the gut commensal, such as genes of the immune system, are described to result in gut dysbiosis that can lead to the development of several autoimmune diseases such as inflammatory bowel disease and type-1 diabetes. Similarly, the diet of an individual shapes the gut microbiota by allowing the predominance of microbes that metabolize an abundant macromolecule in the diet. Epigenetically, the microbial metabolites produced by these microbes can be beneficial in the treatment of cancer or deteriorating by serving as carcinogens. Therefore, the complex association of the gut microbiome with the genetic makeup and diet of an individual plays a significant role in the development of several diseases and health conditions. Recently, the association between the human genome and the gut microbiome has been analyzed and considered a multiomic approach, and extensive genome-wide association studies were conducted to further understand the complex relationship.", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1201/9781003489221-4", "doi": "10.1201/9781003489221-4", "title": "Role of Gut Microbiome on Human Health", "publicationYear": 2025, "publicationDate": "2025-02-10", "type": "book-chapter", "publisher": "CRC Press", "containerTitle": "Gut Microbiome and Environmental Toxicants", "volume": null, "issue": null, "page": "64-85", "issn": null, "isbn": "9781003489221", "authors": "Waleed Hassan Almalki", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1201/9781003489221-4", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.70034/ppp/bk/2026gcm.17", "doi": "10.70034/ppp/bk/2026gcm.17", "title": "Chapter 14 Sleep, Circadian Rhythms, and the Gut Microbiome — Interconnected Systems in Health and Disease", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Pinkpetals publication", "containerTitle": "The Gut-Brain Connection: How Your Microbiome Affects Mental Health", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9789394156333", "authors": "Dr. Rajesh Ranjan, Dr. Rohit Mishra, Dr. Aishwarya Singh", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.70034/ppp/bk/2026gcm.17", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/b978-0-443-29932-2.00010-4", "doi": "10.1016/b978-0-443-29932-2.00010-4", "title": "Protocol - Isolation of gut microbiome from fecal sample", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "Role of Gut Microbiome in Neurodegenerative  Disorders", "volume": null, "issue": null, "page": "205-214", "issn": null, "isbn": "9780443299322", "authors": "H. Nakibapher Jones Shangpliang", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-443-29932-2.00010-4", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.31219/osf.io/ra562", "doi": "10.31219/osf.io/ra562", "title": "A Review of Gut Microbiome Profiling From Metagenomic Analysis &amp;amp; Possible Effects of Antibiotics on Gut Microbiome.", "publicationYear": 2023, "publicationDate": "2023-08-15", "type": "posted-content", "publisher": "Center for Open Science", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "SALMAN IBNE EUNUS", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.31219/osf.io/ra562", "pdfUrl": null, "abstract": "The gut microbiome is the aggregation of all the microorganisms, bacteria, viruses, protozoa and fungi, and their collective genetic material present in the Gastrointestinal Tract (GIT) of human body. Human gut mainly consists of bacteria, both commensal (good) and pathogenic (bad) bacteria in the GIT. It is colonized by 10^14 microbes, which is 10 times more than total human cells. Gut Microbiota has been a topic of research to discover the potential gut microbe-host interactions which includes effects on metabolism, immune system and neuroendocrine responses, etc", "subject": null, "language": null, "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/b978-0-443-40483-2.00040-6", "doi": "10.1016/b978-0-443-40483-2.00040-6", "title": "Role of the gut microbiome in the development of colorectal cancer", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "The Gut Microbiome in Precision Medicine", "volume": null, "issue": null, "page": "477-506", "issn": null, "isbn": "9780443404832", "authors": "Anirudh P. Shanbhag", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 339, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-443-40483-2.00040-6", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/c2021-0-00102-4", "doi": "10.1016/c2021-0-00102-4", "title": "Human-Gut Microbiome", "publicationYear": 2022, "publicationDate": "2022", "type": "edited-book", "publisher": "Elsevier", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780323913133", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/c2021-0-00102-4", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/b978-0-323-91313-3.00008-8", "doi": "10.1016/b978-0-323-91313-3.00008-8", "title": "Gut microbiome-derived metabolites in host health and diseases", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "Human-Gut Microbiome", "volume": null, "issue": null, "page": "81-91", "issn": null, "isbn": "9780323913133", "authors": "Oluwatoyin Sangokunle, Prashant Singh, Ravinder Nagpal", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 66, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-323-91313-3.00008-8", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/b978-0-443-40483-2.00033-9", "doi": "10.1016/b978-0-443-40483-2.00033-9", "title": "Personalized nutrition plans based on gut microbiome analysis", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "The Gut Microbiome in Precision Medicine", "volume": null, "issue": null, "page": "657-669", "issn": null, "isbn": "9780443404832", "authors": "Mark Rector Charles, Denys Charles", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 69, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-443-40483-2.00033-9", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1017/gmb.2024.8", "doi": "10.1017/gmb.2024.8", "title": "“Gut” to grips with the science of the microbiome – a symposium report", "publicationYear": 2024, "publicationDate": "2024", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Gut Microbiome", "volume": "5", "issue": null, "page": null, "issn": "2632-2897", "isbn": null, "authors": "Yvonne E. Finnegan, Holly R. Neill, Emily J. Prpa, Bruno Pot", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 149, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/gmb.2024.8", "pdfUrl": null, "abstract": "Abstract The latest Yakult Science Study Day was held virtually on 2 November 2023. Aimed at healthcare professionals, researchers, and students, a variety of experts explored the latest gut microbiome research and what it means in practice. The morning sessions discussed the role of the microbiome in health and disease, the rapid advancements in DNA sequencing and implications for personalised nutrition, the current state of evidence on health benefits associated with fermented foods, prebiotics and probiotics and the challenges involved in interpreting research in this area. The afternoon session considered the emerging research on the microbiota–gut–brain axis in mediating effects of food on mood, the bidirectional impact of menopause on the gut microbiota, and the interplay between the gut and skin with implications for the treatment of rare and common skin disorders. The session ended with an update on the use of faecal microbiota transplant in both research and clinical practice. Undoubtedly, the gut microbiome is emerging as a key conductor of human health, both in relation to gastrointestinal and non-gastrointestinal outcomes. As research continues to elucidate mechanisms of action and confirm their effects in human trials, the gut microbiome should be a key consideration within a holistic approach to health moving forward.", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1017/gmb.2022.7", "doi": "10.1017/gmb.2022.7", "title": "The microbiome in adult acute appendicitis", "publicationYear": 2022, "publicationDate": "2022", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Gut Microbiome", "volume": "3", "issue": null, "page": null, "issn": "2632-2897", "isbn": null, "authors": "Mei Sze Lee, Arielle Sulit, Frank Frizelle, Rachel Purcell", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/gmb.2022.7", "pdfUrl": null, "abstract": "Abstract Acute appendicitis is a common acute surgical emergency; however, the pathogenesis of adult appendicitis remains poorly understood. The microbiome is increasingly thought to play a key role in inflammatory disease of the bowel and similarly, may play a role in appendicitis. This study aimed to characterise the microbiome of adult acute appendicitis in a prospective cohort. We recruited 60 adults with acute appendicitis and 20 healthy controls. Rectal swabs were taken from each patient. After DNA extraction, 16S rRNA amplicon sequencing was carried out for analysis of diversity and taxonomic abundance. Phylogenetic sequencing of the samples indicated that there is a difference between the microbial composition of those with acute appendicitis and healthy controls, with a statistically significant decrease in alpha diversity in rectal swabs of appendicitis patients compared to healthy controls. At the genus level, we saw an increased abundance of potential pathogens, for example, Parvimonas and Acinetobacter , and a decrease in commensal taxa such as Faecalibacterium, Blautia and Lachnospiraceae in appendicitis patients compared to healthy controls. There was a reduction in diversity and loss of commensals in the microbiome of those with acute appendicitis, which may play a role in the cascade leading to acute appendicitis or the result of this.", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1007/978-981-16-1626-6_8", "doi": "10.1007/978-981-16-1626-6_8", "title": "Gut–Brain Axis: Role of the Gut Microbiome on Human Health", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Springer Nature Singapore", "containerTitle": "Microbiome-Gut-Brain Axis", "volume": null, "issue": null, "page": "187-211", "issn": null, "isbn": "9789811616259, 9789811616266", "authors": "Lipi Poojara, Dhaval K. Acharya, Jalpa Patel, Rakesh M. Rawal", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 136, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-981-16-1626-6_8", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1017/gmb.2023.19", "doi": "10.1017/gmb.2023.19", "title": "List of Reviewers 2023", "publicationYear": 2024, "publicationDate": "2024", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Gut Microbiome", "volume": "5", "issue": null, "page": null, "issn": "2632-2897", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/gmb.2023.19", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.52843/cassyni.7pgg9r", "doi": "10.52843/cassyni.7pgg9r", "title": "Gut Microbiome Wellness Index 2 enhances health status prediction from gut microbiome taxonomic profiles", "publicationYear": 2024, "publicationDate": "2024-10-09", "type": "posted-content", "publisher": "Cassyni", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Jaeyun Sung", "authorCount": 1, "firstAuthorAffiliation": "Mayo Clinic", "isReferencedByCount": 1, "referenceCount": 2, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.52843/cassyni.7pgg9r", "pdfUrl": null, "abstract": "Recent advancements in translational gut microbiome research have revealed its crucial role in shaping predictive healthcare applications. Herein, we introduce the Gut Microbiome Wellness Index 2 (GMWI2), an enhanced version of our original GMWI prototype, designed as a standardized disease-agnostic health status indicator based on gut microbiome taxonomic profiles. Our analysis involves pooling existing 8069 stool shotgun metagenomes from 54 published studies across a global demographic landscape (spanning 26 countries and six continents) to identify gut taxonomic signals linked to disease presence or absence. GMWI2 achieves a cross-validation balanced accuracy of 80% in distinguishing healthy (no disease) from non-healthy (diseased) individuals and surpasses 90% accuracy for samples with higher confidence (i.e., outside the “reject option”). This performance exceeds that of the original GMWI model and traditional species-level α-diversity indices, indicating a more robust gut microbiome signature for differentiating between healthy and non-healthy phenotypes across multiple diseases. When assessed through inter-study validation and external validation cohorts, GMWI2 maintains an average accuracy of nearly 75%. Furthermore, by reevaluating previously published datasets, GMWI2 offers new insights into the effects of diet, antibiotic exposure, and fecal microbiota transplantation on gut health. Available as an open-source command-line tool, GMWI2 represents a timely, pivotal resource for evaluating health using an individual’s unique gut microbial composition.", "subject": null, "language": null, "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1155/agm3/8187081", "doi": "10.1155/agm3/8187081", "title": "Gut Microbiome as a Source and Propagator of Multidrug‐Resistance: Mechanisms and Therapeutic Strategies", "publicationYear": 2026, "publicationDate": "2026-01", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Gut &amp; Microbiome Research", "volume": "2026", "issue": "1", "page": null, "issn": "2755-1652, 2755-1652", "isbn": null, "authors": "Meghana Shashikanth, D. B. M. Virupakshaiah", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 96, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1155/agm3/8187081", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1155/agm3/8187081", "abstract": "Human gut microbiome has risen as a critical nexus in the global landscape of antimicrobial resistance (AMR), acting both as a reservoir and a driver of multidrug‐resistant organisms (MDROs). This review explores the mechanistic foundations by which the gut microbiota contributes to resistance development, focusing on the acquisition and spread of antibiotic resistance genes (ARGs) through horizontal gene transfer, mobile genetic elements, and other ecological imbalances triggered by antibiotic exposure. Strong emphasis is implied on the clinical implications of gut‐mediated resistance in certain high‐exposure settings such as critical care units and immunocompromised patients. We critically evaluate current and emerging therapeutic strategies including fecal microbiota transplantation (FMT), genetically engineered probiotics, phage therapy, enzybiotics, and photodynamic approaches that focus on restoring microbial balance and reducing ARG burden. A novel, three‐tiered microbiome‐aware antimicrobial stewardship model is proposed to guide integration of these strategies into clinical practice. The review concludes with future perspectives on research priorities, including the need for precision resistome surveillance, ethical regulatory frameworks, and microbiome‐informed antibiotic policies. By reframing the gut microbiome from a passive site of colonization to an actionable therapeutic target, this review underscores its centrality in the ongoing battle against AMR.", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1007/978-981-99-8803-7_1", "doi": "10.1007/978-981-99-8803-7_1", "title": "Gut Microbiome and Brain Aging", "publicationYear": 2024, "publicationDate": "2024", "type": "book-chapter", "publisher": "Springer Nature Singapore", "containerTitle": "Gut Microbiome and Brain Ageing", "volume": null, "issue": null, "page": "1-23", "issn": null, "isbn": "9789819988020, 9789819988037", "authors": "Anjana Suresh, Pravi Prasad, Sreejith Parameswara Panicker", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 85, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-981-99-8803-7_1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1017/gmb.2023.1", "doi": "10.1017/gmb.2023.1", "title": "List of Reviewers", "publicationYear": 2023, "publicationDate": "2023", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Gut Microbiome", "volume": "4", "issue": null, "page": null, "issn": "2632-2897", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/gmb.2023.1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1155/2024/9965893", "doi": "10.1155/2024/9965893", "title": "Exploring the Link Between the Gut Mycobiome and Neurological Disorders", "publicationYear": 2024, "publicationDate": "2024-01", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Gut &amp; Microbiome Research", "volume": "2024", "issue": "1", "page": null, "issn": "2755-1652, 2755-1652", "isbn": null, "authors": "Ali Yetgin", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 91, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1155/2024/9965893", "pdfUrl": null, "abstract": "Long‐standing theories link genetics, environmental factors, and microbial dysbiosis as causes of neurological diseases. Even though the role of the human gut mycobiome in these disorders has drawn a lot of attention, recent research has begun to shed light on another microbial component, the gut mycobiome, and its potential involvement in neurological diseases. In an effort to comprehend the connection between the gut mycobiome and neurological illnesses, this exploratory investigation concentrates on the complex interactions between fungal populations and the central nervous system. This study investigates the mechanisms through which fungus species and their metabolites impact brain health and disease progression by evaluating the body of literature and recent discoveries. It also investigates how the gut mycobiome affects the blood–brain barrier’s integrity, the control of neurotransmitters, and immune system modulation. The outcomes provide new information on therapeutic approaches that target the fungal component of the gut microbiota and imply that changes in the composition and function of the gut mycobiome contribute to the onset and progression of neurological diseases. It is necessary to conduct more studies to clarify the precise mechanisms underpinning the gut mycobiome’s impact on neurological illnesses and to investigate the possibility of new diagnostic and therapeutic approaches based on fungus modulation.", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1201/9781003333821-20", "doi": "10.1201/9781003333821-20", "title": "Manipulation of Gut Microbiome to Improve Mental Health", "publicationYear": 2023, "publicationDate": "2023-08-07", "type": "book-chapter", "publisher": "CRC Press", "containerTitle": "Anxiety, Gut Microbiome, and Nutraceuticals", "volume": null, "issue": null, "page": "371-394", "issn": null, "isbn": "9781003333821", "authors": "Sathya Amarasena, Shyamchand Mayengbam", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1201/9781003333821-20", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1007/978-3-031-35064-1_6", "doi": "10.1007/978-3-031-35064-1_6", "title": "Gut Microbiome and Brown Adipose Tissue", "publicationYear": 2024, "publicationDate": "2024", "type": "book-chapter", "publisher": "Springer International Publishing", "containerTitle": "Endocrinology", "volume": null, "issue": null, "page": "157-176", "issn": "2510-1927, 2510-1935", "isbn": "9783031350634, 9783031350641", "authors": "José María Moreno-Navarrete", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 67, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-3-031-35064-1_6", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1201/9781003489221-9", "doi": "10.1201/9781003489221-9", "title": "Effect of Lead on Gut Microbiome", "publicationYear": 2025, "publicationDate": "2025-02-10", "type": "book-chapter", "publisher": "CRC Press", "containerTitle": "Gut Microbiome and Environmental Toxicants", "volume": null, "issue": null, "page": "183-200", "issn": null, "isbn": "9781003489221", "authors": "Yati Sharma, Vibhav Varshney, Ahsas Goyal, Neetu Agrawal", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1201/9781003489221-9", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1186/s40168-023-01565-3", "doi": "10.1186/s40168-023-01565-3", "title": "H2 generated by fermentation in the human gut microbiome influences metabolism and competitive fitness of gut butyrate producers", "publicationYear": 2023, "publicationDate": "2023-06-15", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Microbiome", "volume": "11", "issue": "1", "page": null, "issn": "2049-2618", "isbn": null, "authors": "Austin Campbell, Kristi Gdanetz, Alexander W. Schmidt, Thomas M. Schmidt", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 70, "referenceCount": 79, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1186/s40168-023-01565-3", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s40168-023-01565-3.pdf", "abstract": "Abstract Background Hydrogen gas (H2) is a common product of carbohydrate fermentation in the human gut microbiome and its accumulation can modulate fermentation. Concentrations of colonic H2 vary between individuals, raising the possibility that H2 concentration may be an important factor differentiating individual microbiomes and their metabolites. Butyrate-producing bacteria (butyrogens) in the human gut usually produce some combination of butyrate, lactate, formate, acetate, and H2 in branched fermentation pathways to manage reducing power generated during the oxidation of glucose to acetate and carbon dioxide. We predicted that a high concentration of intestinal H2 would favor the production of butyrate, lactate, and formate by the butyrogens at the expense of acetate, H2, and CO2. Regulation of butyrate production in the human gut is of particular interest due to its role as a mediator of colonic health through anti-inflammatory and anti-carcinogenic properties. Results For butyrogens that contained a hydrogenase, growth under a high H2 atmosphere or in the presence of the hydrogenase inhibitor CO stimulated production of organic fermentation products that accommodate reducing power generated during glycolysis, specifically butyrate, lactate, and formate. Also as expected, production of fermentation products in cultures of Faecalibacterium prausnitzii strain A2-165, which does not contain a hydrogenase, was unaffected by H2 or CO. In a synthetic gut microbial community, addition of the H2-consuming human gut methanogen Methanobrevibacter smithii decreased butyrate production alongside H2 concentration. Consistent with this observation, M. smithii metabolic activity in a large human cohort was associated with decreased fecal butyrate, but only during consumption of a resistant starch dietary supplement, suggesting the effect may be most prominent when H2 production in the gut is especially high. Addition of M. smithii to the synthetic communities also facilitated the growth of E. rectale, resulting in decreased relative competitive fitness of F. prausnitzii. Conclusions H2 is a regulator of fermentation in the human gut microbiome. In particular, high H2 concentration stimulates production of the anti-inflammatory metabolite butyrate. By consuming H2, gut methanogenesis can decrease butyrate production. These shifts in butyrate production may also impact the competitive fitness of butyrate producers in the gut microbiome.", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/b978-0-443-40483-2.00019-4", "doi": "10.1016/b978-0-443-40483-2.00019-4", "title": "Foundations of the gut microbiome: understanding microbial ecology", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "The Gut Microbiome in Precision Medicine", "volume": null, "issue": null, "page": "81-92", "issn": null, "isbn": "9780443404832", "authors": "Priyanshu Kalia, Michael Angelis, Anupama Rani, Danish Qavi", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 58, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-443-40483-2.00019-4", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1155/2022/9695318", "doi": "10.1155/2022/9695318", "title": "Studying the Link between Rheumatoid Arthritis and Gut Dysbiosis: A Mini Review", "publicationYear": 2022, "publicationDate": "2022-11-14", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Gut &amp; Microbiome Research", "volume": "2022", "issue": null, "page": "1-5", "issn": "2755-1652", "isbn": null, "authors": "Mohammad Zulqurnain Haider", "authorCount": 1, "firstAuthorAffiliation": "College of Medicine, QU Health, Qatar University, PO Box 2713, Doha, Qatar", "isReferencedByCount": 2, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1155/2022/9695318", "pdfUrl": "http://downloads.hindawi.com/journals/agmr/2022/9695318.pdf", "abstract": "Rheumatoid arthritis (RA) is an autoimmune disease that affects the joints and may lead to disability. Recent advances have allowed us to study the human gut microbiota in great details. Numerous studies have shown that changes in gut microbiota may be playing a critical role in the pathogenesis of RA. In this review we summarize human and animal studies which show evidence that gut microbiota is directly affecting not only the development of RA but also its progression. In this review we also show evidence on how altering gut microbiota could be used as a treatment for RA.", "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.70034/ppp/bk/2026gcm.18", "doi": "10.70034/ppp/bk/2026gcm.18", "title": "Chapter 15 Microbiome and Gender Differences", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Pinkpetals publication", "containerTitle": "The Gut-Brain Connection: How Your Microbiome Affects Mental Health", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9789394156333", "authors": "Dr. Rajesh Ranjan, Dr. Rohit Mishra, Dr. Aishwarya Singh", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.70034/ppp/bk/2026gcm.18", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/b978-0-323-91313-3.00006-4", "doi": "10.1016/b978-0-323-91313-3.00006-4", "title": "Techniques and challenges in studies related with human gut microbiome", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "Human-Gut Microbiome", "volume": null, "issue": null, "page": "37-57", "issn": null, "isbn": "9780323913133", "authors": "Anamika Verma, Ayushi Sharma, Manoj Kumar, Saurabh Bansal, Rahul Shrivastava", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 56, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-323-91313-3.00006-4", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1016/b978-0-443-40483-2.00027-3", "doi": "10.1016/b978-0-443-40483-2.00027-3", "title": "Role of diet in shaping the gut microbiome", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "The Gut Microbiome in Precision Medicine", "volume": null, "issue": null, "page": "637-655", "issn": null, "isbn": "9780443404832", "authors": "Bilal Siddiqui, Sakshi Tiwari, Saman Fatima, Malik Zainul Abdin", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 130, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-443-40483-2.00027-3", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.70034/ppp/bk/2026gcm.1", "doi": "10.70034/ppp/bk/2026gcm.1", "title": "Preface", "publicationYear": 2026, "publicationDate": "2026", "type": "book-chapter", "publisher": "Pinkpetals publication", "containerTitle": "The Gut-Brain Connection: How Your Microbiome Affects Mental Health", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9789394156333", "authors": "Dr. Rajesh Ranjan", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.70034/ppp/bk/2026gcm.1", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1007/978-3-031-08115-6_6-1", "doi": "10.1007/978-3-031-08115-6_6-1", "title": "Gut Microbiome and Brown Adipose Tissue", "publicationYear": 2023, "publicationDate": "2023", "type": "book-chapter", "publisher": "Springer International Publishing", "containerTitle": "Endocrinology", "volume": null, "issue": null, "page": "1-20", "issn": "2510-1927, 2510-1935", "isbn": "9783031081156, 9783031081156", "authors": "José María Moreno-Navarrete", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 67, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-3-031-08115-6_6-1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.1007/978-3-031-46712-7_1", "doi": "10.1007/978-3-031-46712-7_1", "title": "The Importance of the Microbiome in the Gut", "publicationYear": 2023, "publicationDate": "2023", "type": "book-chapter", "publisher": "Springer Nature Switzerland", "containerTitle": "Clinical Understanding of the Human Gut Microbiome", "volume": null, "issue": null, "page": "1-11", "issn": null, "isbn": "9783031467110, 9783031467127", "authors": "Mark Morrison, Nida Murtaza, Nicholas J. Talley", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 126, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-3-031-46712-7_1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "K4JjcsEve2t6Umcjn", "_dataset_id": "hKFlVn3Zjg2M4HI17"}
{"paperId": "10.33140/atcp.04.01.15", "doi": "10.33140/atcp.04.01.15", "title": "Thermal Simulation Analysis of a Lithium-Ion Battery", "publicationYear": 2021, "publicationDate": "2021-03-21", "type": "journal-article", "publisher": "Opast Group LLC", "containerTitle": "Advances in Theoretical &amp; Computational Physics", "volume": "4", "issue": "1", "page": null, "issn": "2639-0108", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.33140/atcp.04.01.15", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.3724/sp.j.1105.2008.00915", "doi": "10.3724/sp.j.1105.2008.00915", "title": "Sn/C COMPOSITES AS ANODE MATERIAL FOR LITHIUM ION BATTERY", "publicationYear": 2009, "publicationDate": "2009-01-20", "type": "journal-article", "publisher": "China Science Publishing & Media Ltd.", "containerTitle": "Acta Polymerica Sinica", "volume": "008", "issue": "9", "page": "915-919", "issn": "1000-3304", "isbn": null, "authors": "Linjian NING", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 15, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3724/sp.j.1105.2008.00915", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.64336/001c.83933", "doi": "10.64336/001c.83933", "title": "Evaluating the potential of the lithium-carbon dioxide battery to replace the lithium-ion battery", "publicationYear": 2023, "publicationDate": "2023-07-07", "type": "journal-article", "publisher": "Journal of High School Science", "containerTitle": "Journal of High School Science", "volume": "7", "issue": "3", "page": null, "issn": "2575-6206", "isbn": null, "authors": "Raghav Rajan", "authorCount": 1, "firstAuthorAffiliation": "Saratoga High School, 20300 Herriman Ave, Saratoga, CA 95070, USA", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.64336/001c.83933", "pdfUrl": "https://jhss.scholasticahq.com/article/83933-evaluating-the-potential-of-the-lithium-carbon-dioxide-battery-to-replace-the-lithium-ion-battery.pdf", "abstract": "A recent advance in battery research has yielded the discovery of a lithium carbon-dioxide battery (Li-CO2). These batteries capture CO2 from the atmosphere to store and discharge energy. Li-CO2 batteries are an attempt at providing a large-scale battery solution for energy storage. They have a greater energy density (7x that of existing lithium-ion battery (LIB), are safe (fewer short circuit problems) and environmentally friendly (reduced harmful greenhouse gas). However, to date, Li-CO2 batteries have not yet been actively pursued due to a variety of technical challenges in their implementation: an excess buildup of carbon that ruins the battery after a few cycles of charge and discharge, net energy capacity loss with discharge cycles, no definite catalyst to speed up the reaction and research being performed under 100% CO2 partial pressure. By reviewing the current state of Li-CO2 battery, we compare its performance with LIB, and analyze possible advancements in the technology needed before it can become widely available. The goal of this review is to analyze the advantages and drawbacks of the current technological state of Li-CO2 batteries in comparison with the leading technology of LIB, by a techno-economic comparison. Our key findings are that LIBs are currently safer, last longer, discharge more, and are also more economically favorable than Li-CO2 in terms of durability, and cost. However, Li-CO2 batteries are more environmentally friendly, have a greater energy density, making them useful in energy grid balancing, mitigating large voltage fluctuations and in high volume transportation. There are potential applications for both batteries, and we propose steps that the field could take in order to address the challenges we have identified, that stop Li-CO2 batteries from being widely adopted.", "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1002/gch2.201870020", "doi": "10.1002/gch2.201870020", "title": "Lithium‐Ion Batteries: New Insights into the Application of Lithium‐Ion Battery Materials: Selective Extraction of Lithium from Brines via a Rocking‐Chair Lithium‐Ion Battery System (Global Challenges 2/2018)", "publicationYear": 2018, "publicationDate": "2018-02", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Global Challenges", "volume": "2", "issue": "2", "page": null, "issn": "2056-6646, 2056-6646", "isbn": null, "authors": "Lihua He, Wenhua Xu, Yunfeng Song, Yunze Luo, Xuheng Liu, Zhongwei Zhao", "authorCount": 6, "firstAuthorAffiliation": "School of Metallurgy and Environment Central South University  Changsha Hunan 410083 P. R. China", "isReferencedByCount": 5, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/gch2.201870020", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fgch2.201870020", "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.54097/hset.v32i.4953", "doi": "10.54097/hset.v32i.4953", "title": "Feasibility analysis of replacing lithium-ion battery with aqueous zinc-ion battery", "publicationYear": 2023, "publicationDate": "2023-02-12", "type": "journal-article", "publisher": "Darcy & Roy Press Co. Ltd.", "containerTitle": "Highlights in Science, Engineering and Technology", "volume": "32", "issue": null, "page": "108-114", "issn": "2791-0210", "isbn": null, "authors": "Yi Tong", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 15, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.54097/hset.v32i.4953", "pdfUrl": "https://drpress.org/ojs/index.php/HSET/article/download/4953/4800", "abstract": "lithium-ion battery is a battery with intercalated lithium compound as negative electrode material and non-aqueous solution as electrolyte. It is often used as energy supply system for mobile phones, electric vehicles and other equipment. However, due to the instability of lithium and the flammable organic electrolyte, lithium-ion batteries are prone to fire in high temperature or after damage. The paper introduced the technology of aqueous zinc-ion battery and analyzes the merits and drawbacks of it. Aqueous zinc-ion battery is a battery with metallic zinc as negative electrode material. The ingredient of electrolyte is a solution with water as the main component. Compared with lithium-ion battery, it has many excellent characteristics, such as non-toxic, non-flammable, etc. When electronic devices such as smart wearable devices are in close contact with human skin, aqueous zinc-ion batteries can prevent the risk of human skin being burned when the battery damaged or toxic substances penetrating when the battery accidentally leaks. In addition, the high density, high specific energy, much fewer expend and other characteristics of aqueous zinc-ion batteries also increase the possibility that they will replace lithium-ion batteries as energy supply systems for electronic equipment in the future. This paper cites examples to show that the aqueous zinc-ion battery has a good prospect in the field of intelligent wearable devices and has a certain guiding significance for the choice of the energy supply system of intelligent wearable devices in the future.", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.47390/ts-v4i3y2026n13", "doi": "10.47390/ts-v4i3y2026n13", "title": "EXPERIMENTAL INVESTIGATION ON LITHIUM-ION BATTERY AGING UNDER UZBEKISTAN’S CLIMATE", "publicationYear": 2026, "publicationDate": "2026-03-25", "type": "journal-article", "publisher": "LLC Scienceproblems Team", "containerTitle": "Techscience uz - Topical Issues of Technical Sciences", "volume": "4", "issue": "3", "page": "101-114", "issn": "3030-3702", "isbn": null, "authors": "Tojiboy Almataev, Azizbek Zokirjonov", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.47390/ts-v4i3y2026n13", "pdfUrl": "https://techscience.uz/index.php/jurnal/article/download/299/206", "abstract": "Lithium-ion batteries constitute the primary energy source in modern electric vehicles however their long-term degradation represents a fundamental challenge in electrochemical energy-storage research. Temperature extremes such as intense summer heat or severe winter cold can intensify electrochemical degradation, hasten performance decline, and shorten battery life. Recognizing that Uzbekistan exhibits a wide temperature range throughout the year, this study concentrates on the specific impacts of the country’s climatic conditions on battery aging, vehicle reliability, and long-term operational costs. First, the internal aging mechanisms of lithium-ion batteries are reviewed with respect to various anode and cathode chemistries to provide a clearer understanding of capacity fade and performance deterioration. Subsequently, key influencing factors particularly temperature-driven effects on battery life are examined in detail to identify pathways for improving long-term performance. Finally, acknowledging the distinctions between cell-level and system-level behavior, the degradation mechanisms of complete battery systems are analyzed.", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1149/ma2007-02/10/663", "doi": "10.1149/ma2007-02/10/663", "title": "From Lithium to Lithium Ion, a 40 Year Battery Generation (Battery Technology Award Address)", "publicationYear": 2007, "publicationDate": "2007-09-28", "type": "journal-article", "publisher": "The Electrochemical Society", "containerTitle": "ECS Meeting Abstracts", "volume": "MA2007-02", "issue": "10", "page": "663-663", "issn": "2151-2043", "isbn": null, "authors": "Michel Broussely", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://iopscience.iop.org/page/copyright", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1149/ma2007-02/10/663", "pdfUrl": "https://iopscience.iop.org/article/10.1149/MA2007-02/10/663/pdf", "abstract": "Abstract not Available.", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1149/ma2015-03/2/560", "doi": "10.1149/ma2015-03/2/560", "title": "Aqueous Sodium-Ion Battery As Post Lithium-Ion Battery", "publicationYear": 2015, "publicationDate": "2015-07-15", "type": "journal-article", "publisher": "The Electrochemical Society", "containerTitle": "ECS Meeting Abstracts", "volume": "MA2015-03", "issue": "2", "page": "560-560", "issn": "2151-2043", "isbn": null, "authors": "Shigeto Okada, Yusuke Kano, Kosuke Nakamoto", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://iopscience.iop.org/page/copyright", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1149/ma2015-03/2/560", "pdfUrl": "https://iopscience.iop.org/article/10.1149/MA2015-03/2/560/pdf", "abstract": "Three kinds of secondary batteries, nickel metal hydride, Li-ion and Na/S battery were commercialized in Japan for the first time. Among them, Li-ion battery became the most popular power sources for PDA, because of the highest energy density. However, Li-ion battery is difficult to use for large-scale batteries, because its organic electrolytes are flammable, expensive and less conductive. Recently, aqueous electrolyte has been recognized as an attractive alternative and much attention has been paid to its development, because it has 3 big advantages about the conductivity, nonflammability and cost. In addition, water is an ideal solvent that dissolves a lot of various salts. Here, the most important thing is the selection of electrode active materials to avoid decomposition of the aqueous electrolyte. An aqueous Li-ion battery with LiMn2O4 cathode and VO2 anode was first reported by J. R. Dahn's group [1]. Since them, several combinations of cathodes and anodes have been reported as aqueous Li-ion battery. Theoretically, higher cell voltage more than 1.2 V cannot be obtained in the aqueous battery. So, it is unnecessary to dare to use Li in the aqueous batteries. Nevertheless, there is few report about aqueous Na-ion battery, in comparison with aqueous Li-ion battery. As one of the few exceptions, aqueous sodium-ion hybrid device with Na0.44MnO2cathode and active carbon anode was first proposed by Carnegie Mellon University, 4 years ago [2]. In this presentation, we introduce the aqueous Na-ion battery with pyrophosphate Na2FeP2O7 cathode and NASICON-type NaTi2(PO4)3 anodes. Because these polyanionic electrodes have flat voltage plateaus at 3.0 V and 2.1 V vs. Na/Na+, respectively. These redox voltages are almost located within the potential window of the aqueous electrolyte. In addition, Fe and Ti are the first and the second cheapest redox couple in transition metals, respectively. References [1] W. Li, J. R. Dahn and D. S. Wainwright, Science, 264 (1994) 1115. [2] A. D. Tevar and J. F. Whitacre, J. Electrochem. Soc., 157 (2010) A870.", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1016/j.focat.2019.02.052", "doi": "10.1016/j.focat.2019.02.052", "title": "Lithium-ion battery anode including preloaded lithium", "publicationYear": 2019, "publicationDate": "2019-03", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Focus on Catalysts", "volume": "2019", "issue": "3", "page": "7", "issn": "1351-4180", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.focat.2019.02.052", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.21275/sr221228121715", "doi": "10.21275/sr221228121715", "title": "Battery Management Systems for Electric Vehicles using Lithium-Ion Batteries", "publicationYear": 2022, "publicationDate": "2022-12-05", "type": "journal-article", "publisher": "International Journal of Science and Research", "containerTitle": "International Journal of Science and Research (IJSR)", "volume": "11", "issue": "12", "page": "1255-1261", "issn": "2319-7064", "isbn": null, "authors": "Samudrala Hitesh Chandra, Jn Chandra Sekhar", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.21275/sr221228121715", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.54254/2977-3903/11/2024102", "doi": "10.54254/2977-3903/11/2024102", "title": "Quantum battery VS Lithium-ion battery", "publicationYear": 2024, "publicationDate": "2024-09-04", "type": "journal-article", "publisher": "EWA Publishing", "containerTitle": "Advances in Engineering Innovation", "volume": "11", "issue": "1", "page": "49-59", "issn": "2977-3903, 2977-3911", "isbn": null, "authors": "Yuhan Liu", "authorCount": 1, "firstAuthorAffiliation": "Dulwich International High School Suzhou", "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.54254/2977-3903/11/2024102", "pdfUrl": null, "abstract": "This dissertation aims to research how quantum battery work and the comparisons between quantum battery and lithium-ion battery. Lithium-ion batteries are rechargeable energy storage devices that have become widely used in various applications, ranging from portable electronics to electric vehicles. They are known for their high energy density, long cycle life, and relatively low self-discharge rate. Quantum batteries are a relatively new and emerging concept in the field of energy storage. Unlike traditional batteries, which rely on chemical reactions for energy storage, quantum batteries utilize principles from quantum physics to store and release energy. The dissertation uses the available literature review to illustrate the difference between quantum batteries and lithium-ion batteries for storing energy, and which one is better. In terms of current technology, lithium-ion batteries are the best choice for portable charging devices. But in the future, quantum batteries made with advanced technology may replace lithium-ion batteries.", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1595/205651314x685824", "doi": "10.1595/205651314x685824", "title": "Secondary Lithium-Ion Battery Anodes: From First Commercial Batteries to Recent Research Activities", "publicationYear": 2015, "publicationDate": "2015-01-01", "type": "journal-article", "publisher": "Johnson Matthey Plc", "containerTitle": "Johnson Matthey Technology Review", "volume": "59", "issue": "1", "page": "34-44", "issn": "2056-5135", "isbn": null, "authors": "By Nicholas Loeffler, Dominic Bresser, Stefano Passerini, Mark Copley", "authorCount": 4, "firstAuthorAffiliation": "Helmholtz Institute Ulm (HIU)Electrochemistry 1, Helmholtzstraße 11, 89081 UlmGermany", "isReferencedByCount": 69, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1595/205651314x685824", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.7763/jocet.2016.v4.285", "doi": "10.7763/jocet.2016.v4.285", "title": "Beneficial Effects of Active Charge Balancing in Lithium-Ion Battery Systems", "publicationYear": 2015, "publicationDate": "2015", "type": "journal-article", "publisher": "EJournal Publishing", "containerTitle": "Journal of Clean Energy Technologies", "volume": "4", "issue": "3", "page": "225-228", "issn": "1793-821X", "isbn": null, "authors": "M. Raeber, A. Heinzelmann, A. Taeschler", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 13, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.7763/jocet.2016.v4.285", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1097/01.bmsas.0000452534.82188.7e", "doi": "10.1097/01.bmsas.0000452534.82188.7e", "title": "Philips Lithium Ion Battery", "publicationYear": 2014, "publicationDate": "2014-08-15", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Biomedical Safety &amp; Standards", "volume": "44", "issue": "14", "page": "110", "issn": "1080-9775", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1097/01.bmsas.0000452534.82188.7e", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.54097/x8wyc672", "doi": "10.54097/x8wyc672", "title": "Feasibility analysis of replacing lithium-ion battery with sodium ion battery", "publicationYear": 2024, "publicationDate": "2024-04-08", "type": "journal-article", "publisher": "Darcy & Roy Press Co. Ltd.", "containerTitle": "Highlights in Science, Engineering and Technology", "volume": "90", "issue": null, "page": "81-86", "issn": "2791-0210", "isbn": null, "authors": "Fang Hu, Hanjie Lin, Runliang Pan", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.54097/x8wyc672", "pdfUrl": "https://drpress.org/ojs/index.php/HSET/article/download/19763/19350", "abstract": "Since the beginning of the 21st century, the global energy crisis has become a pressing issue, prompting researchers to explore more efficient ways of utilizing energy production and storage technologies in our daily lives. In recent years, there have been major improvements in lithium-ion batteries (LIBs) technology, considerably improving living conditions globally. LIBs are currently commonly employed in electric cars. However, the efficient distribution of renewable energy and smart grids raises concerns, along with the long-term availability of lithium resources. The scarcity and rising costs of lithium metal in recent years have been attributed to substantial price fluctuations. Thus, LIBs have made it difficult to meet the increasing demands of both small and medium to large energy storage applications. Due to the readily available properties of sodium metal, it has similar chemical properties to LIBs. To alleviate these challenges, sodium-ion batteries (SIBs) can be used as the finest candidates for power supply. In recent years, different materials such as metal oxides and phosphates have been introduced as positive electrode materials for SIBs. The use of selected carbonaceous materials, transition metal oxides, intermetallic compounds, and organic compounds as negative electrode materials for SIBs has also contributed to recent developments. SIB is a promising next-generation replacement, but there are still some challenges in the market acceptance of SIBs. In this research, we summarize and compare the market application status of SIB and lithium iron phosphate (LFP), and propose the future development trajectory of SIB and LFP according to their respective characteristics. This will provide a unique insight into practical application problems and market realities.", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.7324/rjc.2017.1031767", "doi": "10.7324/rjc.2017.1031767", "title": "LITHIUM RECOVERY OF SPENT LITHIUM-ION BATTERY USING BIOLEACHING FROM LOCAL SOURCES MICROORGANISM", "publicationYear": 2017, "publicationDate": "2017", "type": "journal-article", "publisher": "Rasayan Journal of Chemistry", "containerTitle": "Rasayan Journal of Chemistry", "volume": null, "issue": null, "page": null, "issn": "0974-1496, 0976-0083", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 11, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.7324/rjc.2017.1031767", "pdfUrl": "http://rasayanjournal.co.in/admin/php/upload/227_pdf.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.21275/sr21902110259", "doi": "10.21275/sr21902110259", "title": "Applications of Rechargeable Lithium - Ion Battery in Electric Vehicles: A Review", "publicationYear": 2021, "publicationDate": "2021-09-27", "type": "journal-article", "publisher": "International Journal of Science and Research", "containerTitle": "International Journal of Science and Research (IJSR)", "volume": "10", "issue": "9", "page": "782-790", "issn": "2319-7064", "isbn": null, "authors": "Zachary Bosire Omariba, Stephen Mageto Gichana", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.21275/sr21902110259", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1007/s42823-020-00210-5", "doi": "10.1007/s42823-020-00210-5", "title": "A criterion combined of bulk and surface lithium storage to predict the capacity of porous carbon lithium-ion battery anodes: lithium-ion battery anode capacity prediction", "publicationYear": 2021, "publicationDate": "2021-10", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Carbon Letters", "volume": "31", "issue": "5", "page": "985-990", "issn": "1976-4251, 2233-4998", "isbn": null, "authors": "Majid Shaker, Ali Asghar Sadeghi Ghazvini, Faisal Raza Qureshi, Reza Riahifar", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 36, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s42823-020-00210-5", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s42823-020-00210-5.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1097/01.bmsas.0000413686.49660.f2", "doi": "10.1097/01.bmsas.0000413686.49660.f2", "title": "Lithium Ion Battery, Charger", "publicationYear": 2012, "publicationDate": "2012-04-15", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Biomedical Safety &amp; Standards", "volume": "42", "issue": "7", "page": "52-53", "issn": "1080-9775", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1097/01.bmsas.0000413686.49660.f2", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1103/physics.17.70", "doi": "10.1103/physics.17.70", "title": "Lithium-Ion “Traffic Jam” Behind Reduced Battery Performance", "publicationYear": 2024, "publicationDate": "2024-04-23", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Physics", "volume": "17", "issue": null, "page": null, "issn": "1943-2879", "isbn": null, "authors": "Rachel Berkowitz", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 1, "isOpenAccess": true, "licenseUrl": "https://link.aps.org/licenses/aps-default-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1103/physics.17.70", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1149/ma2010-02/11/1068", "doi": "10.1149/ma2010-02/11/1068", "title": "Sulphur Lithium-Ion Power: A Novel, High Performance Polymer Tin/Sulphur Lithium-Ion Battery", "publicationYear": 2010, "publicationDate": "2010-07-08", "type": "journal-article", "publisher": "The Electrochemical Society", "containerTitle": "ECS Meeting Abstracts", "volume": "MA2010-02", "issue": "11", "page": "1068-1068", "issn": "2151-2043", "isbn": null, "authors": "Jusef Hassoun, Bruno Scrosati", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://iopscience.iop.org/page/copyright", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1149/ma2010-02/11/1068", "pdfUrl": "https://iopscience.iop.org/article/10.1149/MA2010-02/11/1068/pdf", "abstract": "Abstract not Available.", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.33140/abbsr.05.01.06", "doi": "10.33140/abbsr.05.01.06", "title": "New Rechargeable Lithium-ion AA Battery: More Economic and Eco-friendlier for Home Sleep Apnea Test", "publicationYear": 2022, "publicationDate": "2022-01-10", "type": "journal-article", "publisher": "Opast Group LLC", "containerTitle": "Advances in Bioengineering and Biomedical Science Research", "volume": "5", "issue": "1", "page": null, "issn": "2640-4133", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.33140/abbsr.05.01.06", "pdfUrl": null, "abstract": "Background: Sleep Apnea is a common sleep disorder and Home Sleep Apnea Test (HSAT) is one of the relatively safe and convenient diagnostic screening tools of Sleep Apnea. Nowadays popular devices for HSAT suggesting to use AA batteries for power supply and disposable alkaline battery is recommended in the guideline of most devices. In 2019, a new type of rechargeable AA battery based on lithium-ion was successfully developed and put into the market. Here is the report of 2 years running, observing the performance of the new rechargeable lithium-ion AA battery, in order to proof the possibility and the advantage of the new lithium-ion battery replacing the existing battery. Method: Used Embla MPR PG with ST module to emulate an HSAT for 10 times and log the longest recording time of different battery. And analyze the voltage log of HSAT by Embla X100 in the past 3 years. Evaluate whether the new Rechargeable Lithium-ion battery is competent for HSAT by the longest recording time and the battery status during HSAT. Result: After 2 years of continuous use, the performance of Rechargeable lithium-ion battery was similar to that of Disposable alkaline battery. And Rechargeable lithium-ion battery had a constant voltage throughout the whole recording phase. Conclusion: The new rechargeable lithium-ion AA battery can perfectly replace the traditional disposable alkaline battery in the application of HSAT due to the un-obvious attenuation in 2 years. It also has great advantages in environmental protection and cost saving.", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1149/ma2010-03/1/834", "doi": "10.1149/ma2010-03/1/834", "title": "Sulphur Lithium Ion Power: A Novel, High Performance Polymer Tin/Sulphur Lithium-Ion Battery", "publicationYear": 2010, "publicationDate": "2010-05-27", "type": "journal-article", "publisher": "The Electrochemical Society", "containerTitle": "ECS Meeting Abstracts", "volume": "MA2010-03", "issue": "1", "page": "834-834", "issn": "2151-2043", "isbn": null, "authors": "Jusef Hassoun, Bruno Scrosati", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://iopscience.iop.org/page/copyright", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1149/ma2010-03/1/834", "pdfUrl": "https://iopscience.iop.org/article/10.1149/MA2010-03/1/834/pdf", "abstract": "Abstract not Available.", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.21275/sr21102173054", "doi": "10.21275/sr21102173054", "title": "An Investigation into Sodium-Metal Battery as an Alternative to Lithium-Ion Batteries", "publicationYear": 2021, "publicationDate": "2021-01-27", "type": "journal-article", "publisher": "International Journal of Science and Research", "containerTitle": "International Journal of Science and Research (IJSR)", "volume": "10", "issue": "1", "page": "110-115", "issn": "2319-7064", "isbn": null, "authors": "M M Nishtha Singh", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.21275/sr21102173054", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1097/01.bmsas.0000553626.05873.e0", "doi": "10.1097/01.bmsas.0000553626.05873.e0", "title": "HeartStart MRx Lithium Ion Battery", "publicationYear": 2019, "publicationDate": "2019-03-01", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Biomedical Safety &amp; Standards", "volume": "49", "issue": "4", "page": "27-27", "issn": "1080-9775", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1097/01.bmsas.0000553626.05873.e0", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1063/10.0001312", "doi": "10.1063/10.0001312", "title": "Surface-modified silicon improves lithium-ion battery performance", "publicationYear": 2020, "publicationDate": "2020-05-15", "type": "journal-article", "publisher": "AIP Publishing", "containerTitle": "Scilight", "volume": "2020", "issue": "20", "page": null, "issn": "2572-7907", "isbn": null, "authors": "Raima Larter", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1063/10.0001312", "pdfUrl": "https://pubs.aip.org/aip/sci/article-pdf/doi/10.1063/10.0001312/11946667/201106_1_online.pdf", "abstract": "Investigators show that performance problems with silicon powders in lithium-ion batteries can be partially mitigated using surface modification techniques.", "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1063/pt.5.7288", "doi": "10.1063/pt.5.7288", "title": "A path to better lithium-ion battery performance", "publicationYear": 2016, "publicationDate": "2016-07-28", "type": "journal-article", "publisher": "AIP Publishing", "containerTitle": "Physics Today", "volume": "2016", "issue": "07", "page": null, "issn": "1945-0699", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1063/pt.5.7288", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.4071/001c.129759", "doi": "10.4071/001c.129759", "title": "Applying Machine Learning to the Smart Welding of Cylindrical Lithium-ion Battery Cells within Battery Modules", "publicationYear": 2025, "publicationDate": "2025-02-13", "type": "journal-article", "publisher": "IMAPS - International Microelectronics Assembly and Packaging Society", "containerTitle": "IMAPSource Proceedings", "volume": "2024", "issue": "Symposium", "page": null, "issn": "2380-4505", "isbn": null, "authors": "Mike McKeown", "authorCount": 1, "firstAuthorAffiliation": "Hesse Mechatronics, Inc.", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4071/001c.129759", "pdfUrl": "https://imapsource.org/article/129759-applying-machine-learning-to-the-smart-welding-of-cylindrical-lithium-ion-battery-cells-within-battery-modules.pdf", "abstract": "Battery packs are used in transportation and energy storage applications to provide sufficient power for machine operation. There are various types of battery cell structures as well as numerous methods of interconnecting the battery cells. This paper will focus on cylindrical battery cells, the 21700 type, and Smart Welding as the interconnect technology. Smart Welding is a hybrid version of an ultrasonic welder and an ultrasonic heavy wire bonder that was developed by Hesse GmbH. The problem addressed in this study was that previous research pointed to a need for improvement in determining the optimally smart welding parameters for cylindrical lithium-ion battery cells within a module. By using Taguchi techniques and a Naïve Bayes Classifier, a machine learning algorithm was developed to help determine optimum Smart Weld parameters that produced acceptable weld shear values and nuggets.", "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1063/10.0032402", "doi": "10.1063/10.0032402", "title": "Building a better lithium-ion battery management system", "publicationYear": 2024, "publicationDate": "2024-10-04", "type": "journal-article", "publisher": "AIP Publishing", "containerTitle": "Scilight", "volume": "2024", "issue": "40", "page": null, "issn": "2572-7907", "isbn": null, "authors": "Ben Ikenson", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1063/10.0032402", "pdfUrl": "https://pubs.aip.org/aip/sci/article-pdf/doi/10.1063/10.0032402/20191549/401105_1_10.0032402.pdf", "abstract": "Combining machine learning with traditional method enhances predictive accuracy", "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1063/pt.5.028617", "doi": "10.1063/pt.5.028617", "title": "Longer-lasting lithium-ion battery for cell phones", "publicationYear": 2015, "publicationDate": "2015-02-05", "type": "journal-article", "publisher": "AIP Publishing", "containerTitle": "Physics Today", "volume": "2015", "issue": "02", "page": null, "issn": "1945-0699", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1063/pt.5.028617", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1002/cssc.202400449", "doi": "10.1002/cssc.202400449", "title": "All‐in‐All: Dead Lithium‐Ion Battery to Active Lithium‐Ion Capacitor", "publicationYear": 2025, "publicationDate": "2025-01-02", "type": "journal-article", "publisher": "Wiley", "containerTitle": "ChemSusChem", "volume": "18", "issue": "1", "page": null, "issn": "1864-5631, 1864-564X", "isbn": null, "authors": "Akshay Manohar, Aranganathan Viswanathan, Yun‐Sung Lee, Vanchiappan Aravindan", "authorCount": 4, "firstAuthorAffiliation": "Department of Chemistry Indian Institute of Science Education and Research (IISER)  Tirupati 517619 India", "isReferencedByCount": 10, "referenceCount": 35, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/cssc.202400449", "pdfUrl": null, "abstract": "AbstractHere, we have developed lithium‐ion capacitors (LICs) with all the components, except the electrolyte solution, effectively recycled from the spent Lithium‐ion batteries (LIBs). Hybrid capacitors, such as LICs, are potential breakthroughs in electrochemical energy storage devices, where most research is focused. These devices can simultaneously guarantee high energy and power by hybridizing battery‐type and capacitive‐type electrodes with two different reaction mechanisms. We have successfully upcycled the graphite, current collector, separator, etc., from the spent LIBs to fabricate a high‐performance LIC. Our LIC consists of recovered graphite (RG) coated over recovered copper foil as an anode, recycled polypropylene as the separator, and reduced graphene oxide (rGO) synthesized from RG as the cathode. The RG half‐cell exhibited an excellent specific capacity of 302 mAh g−1 even after 75 charge‐discharge cycles with a coulombic efficiency of &gt;99 %. The Li/rGO displayed remarkable cycling performance for over 1000 cycles with high stability and reversibility. Subsequently, the pre‐lithiated RG (p‐RG) electrode is paired with the rGO electrode under the balanced loading conditions to construct LIC, rGO/p‐RG, delivering a maximum energy density of 185 Wh kg−1 with ultra‐long durability of more than 10,000 cycles. The possibility of LIC under different climatic conditions is also explored, and its remarkable performance under various temperature conditions is worth mentioning.", "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.23940/ijpe.18.12.p28.31843194", "doi": "10.23940/ijpe.18.12.p28.31843194", "title": "Lithium-Ion Battery Management System for Electric Vehicles", "publicationYear": 2018, "publicationDate": "2018", "type": "journal-article", "publisher": "Totem Publisher, Inc.", "containerTitle": "International Journal of Performability Engineering", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Linjie Li", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 11, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.23940/ijpe.18.12.p28.31843194", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.3390/batteries9100502", "doi": "10.3390/batteries9100502", "title": "Stress Distribution Inside a Lithium-Ion Battery Cell during Fast Charging and Its Effect on Degradation of Separator", "publicationYear": 2023, "publicationDate": "2023-10-02", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Batteries", "volume": "9", "issue": "10", "page": "502", "issn": "2313-0105", "isbn": null, "authors": "Mustapha Makki, Cheol W. Lee, Georges Ayoub", "authorCount": 3, "firstAuthorAffiliation": "Department of Industrial and Manufacturing Systems Engineering, University of Michigan-Dearborn, Dearborn, MI 48128, USA", "isReferencedByCount": 11, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Ford Motor Company (Ford-UM Alliance: Development of a Lithium Ion Battery Separator Aging Model)", "funderIds": null, "url": "https://doi.org/10.3390/batteries9100502", "pdfUrl": null, "abstract": "The automotive industry is rapidly transitioning to electric vehicles (EVs) in response to the global efforts to reduce greenhouse gas emissions. Lithium-ion battery (LIB) has emerged as the main tool for energy storage in electric vehicles. A widespread adoption of EVs, however, requires a fast-charging technology that can significantly reduce charging time while avoiding any unsafe conditions including short circuits due to failure of the separator in an LIB cell. Therefore, it is necessary to understand the mechanical stresses during fast charging and their long-term effect on the integrity of the separator. This paper presents a novel hybrid model for the prediction of the stress distribution in the separator of a pouch cell under various charging speeds, ambient temperatures, and pack assembly conditions, such as compressive pressures. The proposed hybrid model consists of three sub-models, namely, an electrochemical cell model, a lumped-parameter model, and a solid mechanics model. A robust parameter identification scheme is implemented to determine the model parameters using the experimental data. The separator within the test setup will experience maximum von Mises stress of 74 MPa during 4C charging, i.e., when the charge current in A is four times as high as the capacity of the battery cell in Ah. To assess the evolution of the damage in the separator under the estimated stress during fast charging, creep and fatigue tests are conducted on the separator. Their results indicate a progressive accumulation of damage in the separator, further emphasizing the importance of understanding and mitigating mechanical degradation in separator materials.", "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1149/ma2016-01/2/268", "doi": "10.1149/ma2016-01/2/268", "title": "Electrochemical Behaviors of All-Phosphate Lithium-Ion Battery and All-Phosphate Solid-State Lithium-Ion Battery", "publicationYear": 2016, "publicationDate": "2016-04-01", "type": "journal-article", "publisher": "The Electrochemical Society", "containerTitle": "ECS Meeting Abstracts", "volume": "MA2016-01", "issue": "2", "page": "268-268", "issn": "2151-2043", "isbn": null, "authors": "Shicheng Yu, Hermann Tempel, Roland Schierholz, Özgür Aslanbas, Josef Mertens, L.G.J. de Haart, Hans Kungl, Rüdiger-Albrecht Eichel", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://iopscience.iop.org/page/copyright", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1149/ma2016-01/2/268", "pdfUrl": "https://iopscience.iop.org/article/10.1149/MA2016-01/2/268/pdf", "abstract": "Lithium-ion batteries are in focus of research around the world, due to their high volumetric and gravimetric energy density. For inorganic all-solid-state batteries since many years considerable effort has been devoted to the development of thin film batteries for their application in microelectronics [1, 2]. Recent research activities are directed to develop high capacity all solid state batteries for automobile applications (Toyota) [3, 4]. These kinds of applications of all-solid-state lithium-ion batteries require high cycling performance, high thermal stability, high capacity and high rate capacity. The main objective of the current work is to build up an all-solid-state battery system which meets the previously listed. Electroactive phosphate materials with different microstructures were synthesized. Based on several combinations of materials, three phosphate compounds were synthesized and used as electrolyte and electrode materials, respectively. The carbon coated cathode (Li3V2(PO4)3/C) and anode (LiTi2(PO4)3/C) materials were first investigated in half-cells that use metallic lithium foil as counter electrode and reference electrode, 1 M LiPF6 in a 1:1 solvent mixture of ethylene carbonate (EC)/dimethyl carbonate (DMC) (LP30) was used as electrolyte. Afterwards, the selected electrode materials were used to make full cells by using LP30 liquid electrolyte. The working voltage, capacity as well as high-rate performance of the full cells were characterized. The optimum ratio of Li3V2(PO4)3/C and LiTi2(PO4)3/C in the full cell was investigated based on the electrochemical performances. Finally, an all-phosphate solid-state lithium-ion battery was made by using the electrode materials and Li1.3Al0.3Ti1.7(PO4)3 solid state electrolyte. The electrochemical behavior of the all-phosphate solid-state lithium-ion battery was investigated and compared with a full cell using liquid LP30 electrolyte. The working voltage of the Li3V2(PO4)3/C-LiTi2(PO4)3/C battery is in the range of 0.2-2.2V, which well matched with the electrochemical window of the solid electrolyte Li1.3Al0.3Ti1.7(PO4)3. Applying materials with high Li-ion conductivities such as Li3V2(PO4)3 and LiTi2(PO4)3provides the advantage of high rate capability for all solid state batteries. Reference [1] M. Koo, K. Park, S. H. Lee, M. S. Duh, D. Y. Jeon, J. W. Choi, K. Kang and K. J. Lee, Nano Lett., 2012, 12, 4810–4816. [2] Y. J. Nam, S. J. Cho, D. Y. Oh, J. M. Lim, S. Y. Kim, J. H. Song, Y. G. Lee, S. Y. Lee and Y. S. Jung, Nano Lett., 2015, 15, 3317–3323. [3] M. S. Beal, B. E. Hayden, T. L. Gall, C. E. Lee, X. Lu, M. Mirsaneh, C. Mormiche, D. Pasero, D. C. A. Smith, A. Weld, C. Yada and S. Yokoishi, ACS Comb. Sci., 2011, 13, 375–381. [4] C. Yada, C. E. Lee, D. Laughman, L. Hannah, H. Iba and B. E. Hayden, J. Electrochem. Soc., 2015, 162, A722–A726.", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1016/j.resconrec.2022.106733", "doi": "10.1016/j.resconrec.2022.106733", "title": "Is it worthwhile to recover lithium-ion battery electrolyte during lithium-ion battery recycling?", "publicationYear": 2023, "publicationDate": "2023-02", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Resources, Conservation and Recycling", "volume": "189", "issue": null, "page": "106733", "issn": "0921-3449", "isbn": null, "authors": "Stephen Vanderburgt, Rafael M. Santos, Yi Wai Chiang", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 14, "referenceCount": 5, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Natural Sciences and Engineering Research Council of Canada", "funderIds": "10.13039/501100000038", "url": "https://doi.org/10.1016/j.resconrec.2022.106733", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.54227/elab.20240015", "doi": "10.54227/elab.20240015", "title": "Strategies of binder design for lithium-ion battery cathodes", "publicationYear": 2024, "publicationDate": "2024", "type": "journal-article", "publisher": "Lab Academic Press", "containerTitle": "Energy Lab", "volume": "2", "issue": null, "page": null, "issn": "2653-7702", "isbn": null, "authors": "Xianluo Hu", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.54227/elab.20240015", "pdfUrl": null, "abstract": "Lithium-ion batteries (LIBs) are crucial for advancing green energy transformation and boosting industrial competitiveness, due to their high energy density, long cycle life, and environmental friendliness. Among the key components of LIBs, cathode materials play a pivotal role in determining overall battery performance. However, these materials face several challenges, including phase transitions, electrolyte corrosion, and low conductivity, which hinder the development of high-energy LIBs. In addition to traditional modification strategies such as doping and micro-structural design, functional binders have emerged as a promising avenue to enhance the electrochemical performance of cathodes. Despite their potential, there is a lack of comprehensive guidance on designing functional binders for high-voltage or high-capacity cathodes, and the relationship between binder design strategies and cathode failure mechanisms is not yet well understood. This review addresses these gaps by summarizing the failure mechanisms of widely used cathodes (e.g., LiCoO2, LiNixCoyMnzO2, xLi2MnO3·(1−x)LiTMO2, LiNi0.5Mn1.5O4, and LiFePO4) in LIBs. We discuss the roles of functional binders in mitigating these failures and examine the associated failure mechanisms. Finally, we highlight design strategies for advanced functional binders and explore their potential to enable next-generation high-energy LIBs.", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1149/ma2020-022278mtgabs", "doi": "10.1149/ma2020-022278mtgabs", "title": "Synchronized Lithium and Lithium-Ion Battery Enabled to in-Situ Replenishment for Enhancing Battery Life", "publicationYear": 2020, "publicationDate": "2020-11-23", "type": "journal-article", "publisher": "The Electrochemical Society", "containerTitle": "ECS Meeting Abstracts", "volume": "MA2020-02", "issue": "2", "page": "278-278", "issn": "2151-2043", "isbn": null, "authors": "Manikandan Palanisamy, Mihit H. Parekh, Vilas G. Pol", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://iopscience.iop.org/page/copyright", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1149/ma2020-022278mtgabs", "pdfUrl": "https://iopscience.iop.org/article/10.1149/MA2020-022278mtgabs/pdf", "abstract": "In-situ replenishment of formation cycle lithium-ion loss is considered for the development of longer-lasting rechargeable batteries that uses lithium-electrode, which acts as a reservoir and booster-electrode to mitigate the formation cycle capacity loss in mesocarbon microbeads (MCMB) anode vs LiFePO4 cathode and C-Si anode vs LiNi1/3Mn1/3Co1/3O2 cathode in standard electrolyte. For the synchronized lithium and lithium-ion battery (SLLIB) – full-cell specific charge- discharge capacities were 146/ 144 mAh g–1 for MCMB vs LiFePO4 and 187/ 171 mAh g–1 for C-Si vs LiNi1/3Mn1/3Co1/3O2 configurations at 0.2 C rate. The irreversible capacity loss compensation from the reservoir-electrode, offered to a renewed voltage profiles and recovered electrodes specific capacities by reservoir replenishment and replenished cycling. The energy reduced cell due to SEI formation of MCMB and C-Si anodes was replenished and achieved increased energy density of 455 Wh kg–1 with retained flat-voltage profile for SLLIB – MCMB vs LiFePO4 and 576 Wh kg–1 for SLLIB – C-Si vs LiNi1/3Mn1/3Co1/3O2 through Li+ ion in-situ reservoir replenishment from the reservoir-electrode to MCMB/ C-Si anode. Furthermore, reservoir reserve mode cycling of SLLIB configurations were delivered the charge-discharge capacities of 126/ 124 mAh g–1 for SLLIB – Li vs LiFePO4 and 137/ 136 mAh g–1 for SLLIB – Li vs LiNi1/3Mn1/3Co1/3O2 at 0.2 C, associated with the Li+ ion transportation between reservoir-electrode and LiFePO4/ LiNi1/3Mn1/3Co1/3O2 cathode, confirmed by Li+ ion diffusion path through MCMB and C-Si electrodes, using EIS analysis. Ultimately, the in-situ reservoir replenishment, replenished cycling and reserve mode cycling processes of synchronized lithium and lithium-ion battery leads to enhanced battery life. Figure 1", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1595/205651315x685445", "doi": "10.1595/205651315x685445", "title": "Automotive Lithium-Ion Batteries", "publicationYear": 2015, "publicationDate": "2015-01-01", "type": "journal-article", "publisher": "Johnson Matthey Plc", "containerTitle": "Johnson Matthey Technology Review", "volume": "59", "issue": "1", "page": "4-13", "issn": "2056-5135", "isbn": null, "authors": "By Peter Miller", "authorCount": 1, "firstAuthorAffiliation": "Johnson Matthey Battery SystemsOrchard Road, Royston, Hertfordshire, SG8 5HEUK", "isReferencedByCount": 56, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1595/205651315x685445", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1093/ijlct/ctaf130", "doi": "10.1093/ijlct/ctaf130", "title": "Lithium-ion battery equalization control strategy for photovoltaic-battery energy storage systems", "publicationYear": 2025, "publicationDate": "2025-01-24", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "International Journal of Low-Carbon Technologies", "volume": "20", "issue": null, "page": "1960-1965", "issn": "1748-1325", "isbn": null, "authors": "Xia Zhao", "authorCount": 1, "firstAuthorAffiliation": "College of intelligent manufacturing, ZhengZhou Technical College , No. 081, Zhengshang Road, Zhengzhou, Henan 450121 ,", "isReferencedByCount": 1, "referenceCount": 18, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/ijlct/ctaf130", "pdfUrl": "https://academic.oup.com/ijlct/article-pdf/doi/10.1093/ijlct/ctaf130/65360189/ctaf130.pdf", "abstract": "Abstract In this paper, the battery equalization technology of LiFePO4 battery energy storage system applied in photovoltaic is studied, using passive equalization circuit instead of active equalization circuit because passive equalization circuit is more suitable, and the shortcomings of the standard equalization control strategy applied to LiFePO4 battery are analyzed in detail, which is mainly caused by the characteristics of LiFePO4 battery, and this paper also proposes optimization scheme to improve the performance. An experimental platform is built for testing to prove the feasibility of the proposed strategy.", "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.55248/gengpi.07.0626.17b16", "doi": "10.55248/gengpi.07.0626.17b16", "title": "Hybrid Quantum-Classical Optimization for Lithium-Ion Battery Systems and Resilient Supply Chains under Disruption", "publicationYear": 2026, "publicationDate": "2026-06", "type": "journal-article", "publisher": "Genesis Global Publication", "containerTitle": "International Journal of Research Publication and Reviews", "volume": "7", "issue": "6", "page": "6102-6107", "issn": "2582-7421", "isbn": null, "authors": "Padmaja Padmaja", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.55248/gengpi.07.0626.17b16", "pdfUrl": null, "abstract": "The Laplace–Weierstrass (LW) transform combines the Laplace transform with Weierstrass Gaussian smoothing to deliver built-in regularization for dynamic systems characterized by noise and incomplete observations. This paper presents significant extensions including a rigorously justified existence theorem, explicit inversion with regularization, convolution and fractional-order theorems, and stable numerical discretization. These advances enable efficient analytical and numerical treatment of linear and integro-differential equations with noisy data. The framework is applied to electric vehicle battery systems for lithium-ion modeling, parameter estimation, SoC/SoH analysis, and hybrid power-flow optimization under thermal constraints, as well as to resilient supply chains for inventory dynamics with lead-time delays, disruption recovery trajectories, and bullwhip effect mitigation. It further supports a hybrid quantum classical approach that pairs LW-based dimensionality reduction with quantum annealing for large scale logistics optimization under disruption. Numerical benchmarks confirm substantially improved parameter recovery accuracy and orders-of-magnitude faster computation compared with classical methods. The resulting tools are well-suited for real-time estimation, digital-twin development, and decision support in sustainable mobility and robust logistics", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1002/er.3282", "doi": "10.1002/er.3282", "title": "Correlating uncertainties of a lithium-ion battery - A Monte Carlo simulation", "publicationYear": 2015, "publicationDate": "2015-05", "type": "journal-article", "publisher": "Hindawi Limited", "containerTitle": "International Journal of Energy Research", "volume": "39", "issue": "6", "page": "778-788", "issn": "0363-907X", "isbn": null, "authors": "Wei Tong, Wei Qiang Koh, Erik Birgersson, Arun S. Mujumdar, Christopher Yap", "authorCount": 5, "firstAuthorAffiliation": "Department of Mechanical Engineering; National University of Singapore; Singapore 117576", "isReferencedByCount": 26, "referenceCount": 31, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/er.3282", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1149/ma2013-02/14/1092", "doi": "10.1149/ma2013-02/14/1092", "title": "Fast Lithium Ion Conducting Ceramics for All-Solid-State Lithium-Ion Battery", "publicationYear": 2013, "publicationDate": "2013-10-27", "type": "journal-article", "publisher": "The Electrochemical Society", "containerTitle": "ECS Meeting Abstracts", "volume": "MA2013-02", "issue": "14", "page": "1092-1092", "issn": "2151-2043", "isbn": null, "authors": "Koichi Hamamoto, Toshiaki Yamaguchi, Hirofumi Sumi, Toshio Suzuki, Yoshinobu Fujishiro", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://iopscience.iop.org/page/copyright", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1149/ma2013-02/14/1092", "pdfUrl": "https://iopscience.iop.org/article/10.1149/MA2013-02/14/1092/pdf", "abstract": "Abstract not Available.", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.24012/dumf.1528158", "doi": "10.24012/dumf.1528158", "title": "Temperature Prediction of Lithium-ion Battery by CPSO-UKF", "publicationYear": 2024, "publicationDate": "2024-09-30", "type": "journal-article", "publisher": "Dicle Universitesi Muhendislik Fakultesi Muhendislik Dergisi", "containerTitle": "DÜMF Mühendislik Dergisi", "volume": null, "issue": null, "page": null, "issn": "1309-8640", "isbn": null, "authors": "Göksu Taş", "authorCount": 1, "firstAuthorAffiliation": "MANISA CELAL BAYAR UNIVERSITY", "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.24012/dumf.1528158", "pdfUrl": null, "abstract": "In this study, the temperature estimation of lithium-ion batteries is proposed by Chaos Particle Swarm Algorithm-Unscented Kalman Filter (UKF). 18650-type lithium-ion batteries are widely used in electric vehicles due to their compact design and long life. The accurate estimation of the temperature parameter of these batteries is critical for reasons such as balancing the performance and predicting chemical degradation. Therefore, in this study, the temperature parameter estimation of an 18650-type lithium-ion battery is made by UKF-based methods. Due to the intensive and mathematical processing load of the UKF method, the parameter values are determined by Chaos Particle Swarm Optimization (PSO) methods, and their estimation performances are compared. The parameter values such as alpha, kappa, and R matrix of the UKF method are determined by Particle Swarm Optimization (PSO), Chaos Particle Swarm Optimization (CPSO), Comprehensive Learning Particle Swarm Optimization (CLPSO), and hyperparameter values determined by trial and error. The hyperparameter values obtained from these four different methods were applied to the UKF method separately and their estimation performances were compared. The CPSO-UKF method became the most successful method by reaching an accuracy of 99.99228% in estimation according to the R2 metric. The success of the proposed method is also given with other regression metrics.", "subject": null, "language": "tr", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1016/s1350-4789(17)30204-0", "doi": "10.1016/s1350-4789(17)30204-0", "title": "Secondary seal for lithium-ion battery cell", "publicationYear": 2017, "publicationDate": "2017-06", "type": "journal-article", "publisher": "Auricle Global Society of Education and Research", "containerTitle": "Sealing Technology", "volume": "2017", "issue": "6", "page": "15", "issn": "1350-4789", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s1350-4789(17)30204-0", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1016/s1350-4789(14)70313-7", "doi": "10.1016/s1350-4789(14)70313-7", "title": "Improved seal for bipolar lithium-ion battery", "publicationYear": 2014, "publicationDate": "2014-08", "type": "journal-article", "publisher": "Auricle Global Society of Education and Research", "containerTitle": "Sealing Technology", "volume": "2014", "issue": "8", "page": "14", "issn": "1350-4789", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s1350-4789(14)70313-7", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.17303/jmsa.2023.7.103", "doi": "10.17303/jmsa.2023.7.103", "title": "Nonstoichiometric Lithium Iron Phosphate for Lithium-Ion Battery Prepared by Supercritical Hydrothermal Synthesis", "publicationYear": 2023, "publicationDate": "2023-12-15", "type": "journal-article", "publisher": "Jscholar Publishers", "containerTitle": "JMSA", "volume": "7", "issue": "1", "page": null, "issn": null, "isbn": null, "authors": "Kyoo-Seung Han", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.17303/jmsa.2023.7.103", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1149/ma2019-02/5/303", "doi": "10.1149/ma2019-02/5/303", "title": "Prototype Aqueous Lithium-Ion Battery with a Lithium-Ion Conductive Solid Electrolyte Separator", "publicationYear": 2019, "publicationDate": "2019-09-01", "type": "journal-article", "publisher": "The Electrochemical Society", "containerTitle": "ECS Meeting Abstracts", "volume": "MA2019-02", "issue": "5", "page": "303-303", "issn": "2151-2043", "isbn": null, "authors": "Hayato Seki, Kazuomi Yoshima, Yasunobu Yamashita, Shinsuke Matsuno, Norio Takami", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://iopscience.iop.org/page/copyright", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1149/ma2019-02/5/303", "pdfUrl": "https://iopscience.iop.org/article/10.1149/MA2019-02/5/303/pdf", "abstract": "Lithium-ion batteries (LIBs) with a non-aqueous electrolyte are capable of high energy density, high power output, and long cycle performance. These batteries are regarded as the most promising sources of power for electric vehicles (EVs), hybrid electric vehicles (HEVs), and grid storage. However, current LIBs pose a safety risk due to their flammable organic electrolytes. In contrast, lithium-ion batteries with aqueous electrolytes are safer and cost less than current LIBs, but the electrochemical stability window of aqueous electrolytes is narrower than that of the organic electrolytes used in LIBs. The stable operating voltage window of an aqueous electrolyte is approximately 1.23 V thermodynamically, beyond which the electrolysis of H2O occurs along with the evolution of H2 or O2 gas. As illustrated by a Pourbaix diagram, the overall electrochemical stability window of aqueous electrolytes is constant and independent of the pH of the electrolytes. In this study, we report the widening of the overall electrochemical stability window with two electrolytes having different pH values. We utilized a lithium-ion conductive solid electrolyte to separate the electrolytes into the cathode and anode sides of an aqueous lithium-ion battery in order to suppress the evolution of oxygen and hydrogen. In particular, we fabricated an aqueous lithium-ion cell with a lithium-ion conductive solid electrolyte as the separator between two inorganic lithium salt layers. A spinel lithium manganese oxide (LMO) was used as the cathode active material while a spinel lithium titanate oxide (LTO) with a Li+ insertion potential of 1.55 V vs. Li was used as the anode active material, leading to less hydrogen evolution compared with the graphite anodes used in current LIBs. A lithium-ion ceramic plate (LICGC™, Ohara Inc.) with a thickness 150 µm and conductivity 10-4 S/cm at 25°C was used as the separator. The plate was able to separate the different electrolytes into the cathode and anode sides. Then, 2 mol/L Li2SO4 and 12 mol/L LiCl, both of which have higher conductivity than the organic electrolytes of current LIBs, were used as the cathode and anode electrolytes, respectively. The cell was constructed with an LMO cathode electrode (10 mm in diameter, 0.1 mm thick), an LTO anode electrode (approximately the same dimensions as the cathode), the solid electrolyte separator (2.5 ´ 2.5 cm, 150 µm thick), and an aqueous solution with 2 mol/L Li2SO4 and 12 mol/L LiCl as the cathode and anode electrolyte, respectively. The charge/discharge current density was 0.282 mA/cm2 at the 1C rate. Figure 1 shows the charge and discharge curves of the LMO/LTO cell at the 20th cycle (25°C). The aqueous test cell exhibited an average discharge voltage of over 2.4 V and a coulombic efficiency of over 94%. Figure 2 shows the cycling stability and coulombic efficiencies of aqueous LMO/LTO cells at the 1C rate. To prevent drying of the electrolyte in a long-term experiment, 12 mol/L LiCl was used as electrolytes for both the cathode and anode. The retention of discharge capacity and coulombic efficiency was approximately 100% after 1000 cycles. The coulombic efficiency of the initial cycle, in which the pH of the 12 mol/L LiCl electrolyte was neutral (measured with pH test paper), was relatively low. During the 20th cycle, which had relatively low coulombic efficiency, the anode electrolyte changed from acidic to basic and hydrogen evolution with electrolysis of water was suppressed. After the 20th cycle, the electrolyte pH at the anode electrode surface was close to 14, whereas the entire electrolyte pH was close to neutral. The pH of the local electrolyte, situated between the anode electrode surface and the solid electrolyte separator, changed from acidic to basic, resulting in the suppression of oxygen and hydrogen gas generation without changing the pH of the cathode electrolyte. The initial coulombic efficiency was dependent on the anode electrolyte pH due to the lower coulombic efficiency of the anode compared with the cathode. Additional electrochemical tests will be reported in the future. Figure 1", "subject": null, "language": null, "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.3390/batteries10010038", "doi": "10.3390/batteries10010038", "title": "A Review of Lithium-Ion Battery Recycling: Technologies, Sustainability, and Open Issues", "publicationYear": 2024, "publicationDate": "2024-01-22", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Batteries", "volume": "10", "issue": "1", "page": "38", "issn": "2313-0105", "isbn": null, "authors": "Alessandra Zanoletti, Eleonora Carena, Chiara Ferrara, Elza Bontempi", "authorCount": 4, "firstAuthorAffiliation": "INSTM and Chemistry for Technologies Laboratory, University of Brescia, Via Branze 38, 25123 Brescia, Italy", "isReferencedByCount": 229, "referenceCount": 173, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Fondazione Cariplo through the grant “Tech4Lib–Spent Lithium ion battery recovery”, Fondazione Cariplo through the grant “Tech4Lib–Spent Lithium ion battery recovery”, Fondazione Cariplo through the grant “Tech4Lib–Spent Lithium ion battery recovery”, Fondazione Cariplo through the grant “Tech4Lib–Spent Lithium ion battery recovery”, Fondazione Cariplo through the grant “Cathode Recovery for Lithium-Ion Battery Recycling, COLIBRI”, Fondazione Cariplo through the grant “Cathode Recovery for Lithium-Ion Battery Recycling, COLIBRI”, Fondazione Cariplo through the grant “Cathode Recovery for Lithium-Ion Battery Recycling, COLIBRI”, Fondazione Cariplo through the grant “Cathode Recovery for Lithium-Ion Battery Recycling, COLIBRI”, Regione Lombardia for the project Regional Hub for Circular Economy, R2BATT Laboratory, Regione Lombardia for the project Regional Hub for Circular Economy, R2BATT Laboratory, Regione Lombardia for the project Regional Hub for Circular Economy, R2BATT Laboratory, Regione Lombardia for the project Regional Hub for Circular Economy, R2BATT Laboratory, MUR-PRIN “enhanced metals recovery by coordination chemistry from lithium batteries waste–ERCOLE”, MUR-PRIN “enhanced metals recovery by coordination chemistry from lithium batteries waste–ERCOLE”, MUR-PRIN “enhanced metals recovery by coordination chemistry from lithium batteries waste–ERCOLE”, MUR-PRIN “enhanced metals recovery by coordination chemistry from lithium batteries waste–ERCOLE”, Next-GenerationEU, Next-GenerationEU, Next-GenerationEU, Next-GenerationEU, MICS (Made in Italy–Circular and Sustainable) Extended Partnership, MICS (Made in Italy–Circular and Sustainable) Extended Partnership, MICS (Made in Italy–Circular and Sustainable) Extended Partnership, MICS (Made in Italy–Circular and Sustainable) Extended Partnership", "funderIds": null, "url": "https://doi.org/10.3390/batteries10010038", "pdfUrl": null, "abstract": "Lithium-ion batteries (LIBs) are a widely used energy storage technology as they possess high energy density and are characterized by the reversible intercalation/deintercalation of Li ions between electrodes. The rapid development of LIBs has led to increased production efficiency and lower costs for manufacturers, resulting in a growing demand for batteries and their application across various industries, particularly in different types of vehicles. In order to meet the demand for LIBs while minimizing climate-impacting emissions, the reuse, recycling, and repurposing of LIBs is a critical step toward achieving a sustainable battery economy. This paper provides a comprehensive review of lithium-ion battery recycling, covering topics such as current recycling technologies, technological advancements, policy gaps, design strategies, funding for pilot projects, and a comprehensive strategy for battery recycling. Additionally, this paper emphasizes the challenges associated with developing LIB recycling and the opportunities arising from these challenges, such as the potential for innovation and the creation of a more sustainable and circular economy. The environmental implications of LIB recycling are also evaluated with methodologies able to provide a sustainability analysis of the selected technology. This paper aims to enhance the comprehension of these trade-offs and encourage discussion on determining the “best” recycling route when targets are in conflict.", "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1002/est2.208", "doi": "10.1002/est2.208", "title": "Modeling of analog battery management system for single cell lithium ion battery", "publicationYear": 2021, "publicationDate": "2021-08", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Energy Storage", "volume": "3", "issue": "4", "page": null, "issn": "2578-4862, 2578-4862", "isbn": null, "authors": "Hemavathi S", "authorCount": 1, "firstAuthorAffiliation": "CSIR‐Central Electrochemical Research Institute (CECRI) CSIR‐Madras Complex  Chennai India", "isReferencedByCount": 5, "referenceCount": 19, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/est2.208", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/est2.208", "abstract": "AbstractThe Li‐ion battery is an energy storage system in consumer and industrial applications. Because of their cell and pack level protection, Li‐ion battery requires a battery management system (BMS). The important function of the BMS is to monitor and protect the Li‐ion battery cells and packs from fault conditions, in order to maximize their lifecycle and increase safety features. In this research article, an analog BMS is presented for the protection of nickel manganese cobalt oxide‐chemistry‐based single‐cell Li‐ion battery. The Analog BMS is a battery protection circuit module that includes battery protection integrated circuit to protect batteries from overvoltage, undervoltage, overcurrent charging, and overcurrent discharging conditions. In addition, the semiconductor switches are used for charge and discharge protection control. This protection circuit module is designed for 18650 single‐cell Li‐ion battery and test the performance of analog BMS based on protection parameters. A real‐time experiment is carried out on analog BMS interconnected with 18650 single‐cell Li‐ion battery and tested under different charge and discharge rates using standard constant current‐constant voltage (CC‐CV) charging method. The experimental results show that the developed analog BMS protected single‐cell Li‐ion battery from overvoltage, undervoltage, overcurrent charging, and discharging conditions under different C/5, C/2, and 1C rates.", "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.1063/5.0139773", "doi": "10.1063/5.0139773", "title": "An insight into lithium-ion transport in germanium-doped lithium titanate anode through NMR spectroscopy and post-carbonization for anode applications in lithium-ion battery", "publicationYear": 2023, "publicationDate": "2023-03-06", "type": "journal-article", "publisher": "AIP Publishing", "containerTitle": "Applied Physics Letters", "volume": "122", "issue": "10", "page": null, "issn": "0003-6951, 1077-3118", "isbn": null, "authors": "Sreejith O. V., Arunkumar Dorai, Junichi Kawamura, Murugan Ramaswamy", "authorCount": 4, "firstAuthorAffiliation": "High Energy Density Batteries Research Laboratory, Department of Physics, Pondicherry University 1 , Puducherry 605 014, India", "isReferencedByCount": 5, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1063/5.0139773", "pdfUrl": "https://pubs.aip.org/aip/apl/article-pdf/doi/10.1063/5.0139773/16774496/103904_1_online.pdf", "abstract": "Adapting toward lithium titanate as a negative electrode for lithium-ion batteries led to the safest and long-lasting battery technology, especially for electric vehicle applications. However, the poor conductivity and lithium-ion diffusion of lithium titanate have to be addressed for widespread usage in next-generation E-mobility. The lithium-ion motion inside lithium titanate and germanium-doped lithium titanate was investigated through pulsed-field gradient nuclear magnetic resonance spectroscopy and temperature-dependent ionic conductivity studies. The superior charge carrier mobility of germanium enhanced the lithium-ion diffusion in lithium titanate significantly to 1.48 × 10−8 cm2 s−1 in Li4Ge0.1Ti4.9O12 at 500 °C. While germanium improves the ionic diffusion, an ex situ carbon coating was adapted over the sample for electronic conductivity enhancement. Samples with two different carbon contents (5 and 10 wt. %) were examined for electrochemical analysis. Significant improvements in battery performance were observed on carbon-coated germanium-doped lithium titanate. The carbon-coated sample gave superior initial performance (191 and 178 mAh g−1 for 10 and 5 wt. % carbon at 0.1C) than the pristine lithium titanate and preserved the exceptional capacity retention over a thousand cycles at 1C rate.", "subject": null, "language": "en", "_run_id": "7TKe76uJOAyGT3oW8", "_dataset_id": "A2XRduwfPh8b5vnpX"}
{"paperId": "10.62830/mmj1-2-16b", "doi": "10.62830/mmj1-2-16b", "title": "CAR-T Cell Therapy in Rheumatic Diseases", "publicationYear": 2024, "publicationDate": "2024-06-15", "type": "journal-article", "publisher": "Max Healthcare Institute Limited", "containerTitle": "CAR-T Cell Therapy in Rheumatic Diseases", "volume": "II", "issue": "1", "page": null, "issn": null, "isbn": null, "authors": "Hiren Kalyani, P.D Rath, Shwetal Chouhan, Mayank Goyal, Tejaswee Banavathu", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.62830/mmj1-2-16b", "pdfUrl": null, "abstract": "CAR-T cell (Chimeric Antigen Receptor-T cell) therapy has revolutionized the treatment of various hematologic malignances. CD19 targeted CAR-T cell therapy is coming in a big way in rheumatic diseases. Recent case reports and case series have shown encouraging results in diseases like systemic lupus erythematosus (SLE), systemic sclerosis and antisynthetase syndrome which have been refractory to multiple existing therapies. The dramatic response encompasses objective improvement across multiple clinical domains as well as seroconversion. Side effects of concern with CAR-T cell therapy are related to release of pro-inflammatory cytokines and include cytokine release syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS). The reported side effects of this therapy for autoimmune diseases were of low grade and were managed without any fatality. Several modifications in CAR-T cell therapy have been proposed to maximize the safety and improving the efficacy. This therapy has got the potential to be a major breakthrough in management of rheumatic diseases, especially wherein existing therapies have been refractory.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1093/med/9780190097653.003.0029", "doi": "10.1093/med/9780190097653.003.0029", "title": "Hematopoietic Dyscrasias and Stem Cell Transplantation/CAR-T Cell Therapy", "publicationYear": 2021, "publicationDate": "2021-02", "type": "book-chapter", "publisher": "Oxford University Press", "containerTitle": "Psycho-Oncology", "volume": null, "issue": null, "page": "203-214", "issn": null, "isbn": "9780190097653, 9780190097684", "authors": "Jesse R. Fann, Nicole Bates", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/med/9780190097653.003.0029", "pdfUrl": null, "abstract": "This chapter describes the epidemiology, clinical presentation, assessment, and management of the many psychosocial issues and neuropsychiatric syndromes that may arise in patients with hematopoietic dyscrasias, including those undergoing hematopoietic stem cell transplantation (HSCT) and chimeric antigen receptor T (CAR-T) cell therapy. We focus our discussion on adults who are undergoing acute treatment and briefly discuss issues faced by long-term survivors, families, and caregivers. Although an increasing body of literature supports evidence-based management strategies, clinical recommendations for treatment continue to incorporate both empirical evidence and expert opinion. We conclude by proposing directions for future research that will lead to improved care and outcomes for this population.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.4018/979-8-3373-2096-0.ch006", "doi": "10.4018/979-8-3373-2096-0.ch006", "title": "CAR-T Cell Therapy", "publicationYear": 2025, "publicationDate": "2025-10-03", "type": "book-chapter", "publisher": "IGI Global Scientific Publishing", "containerTitle": "Advancements in the Diagnostics and Therapeutics for Non-Small Cell Lung Carcinoma (NSCLC)", "volume": null, "issue": null, "page": "163-196", "issn": null, "isbn": "9798337320960, 9798337320984", "authors": "Prerna Mehta", "authorCount": 1, "firstAuthorAffiliation": "G.D. Rungta College of Science and Technology, Bhilai, India", "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4018/979-8-3373-2096-0.ch006", "pdfUrl": null, "abstract": "There is rising interest in CAR-T therapy as a potential treatment of non-small cell lung cancer (NSCLC) that comprises about 85% of all lung cancer and has a high mortality rate. This is a new technology whereby T cells are engineered to attack certain tumor-specific antigens. However, it tends to be undermined by other factors (i.e., the immunosuppressive tumor microenvironment and antigen heterogeneity). More recent data have found epidermal growth factor receptor (EGFR) and mesothelin as future targets of CAR-T therapy. The development of cars such as dual-targeting CAR improves the efficiency of treatment. However, there also exist some challenges such as safety concerns such as cytokine release syndrome (CRS). To overcome immunosuppressive barriers, CAR-T/immune checkpoint combination therapy can be used as an added advantage. Further research on new CAR-T regimens and trials is needed to improve patient treatment outcomes and survival in patients with NSCLC, a complex and advanced disease.", "subject": null, "language": "ng", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.26686/wgtn.29367701", "doi": "10.26686/wgtn.29367701", "title": "Honing the safety and delivery of CAR T-cell therapy", "publicationYear": 2025, "publicationDate": "2025-06-20", "type": "dissertation", "publisher": "Victoria University of Wellington Library", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Robert Fyfe", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.wgtn.ac.nz/library/about-us/policies-and-strategies/copyright-for-the-researcharchive", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26686/wgtn.29367701", "pdfUrl": null, "abstract": "&lt;p&gt;&lt;strong&gt;Chimeric antigen receptor (CAR) T-cell therapy is an emerging and evolving therapy for haematological malignancies, with the potential for broader use for other malignancies and autoimmune conditions. Although this therapy is now standard of care in many countries for B-cell non-Hodgkin lymphoma, the clinical delivery of this therapy continues to be refined, as its clinical application catches up to the impressive underlying science. In this thesis I present three projects on the theme of improving the clinical delivery of CAR T-cell therapy for B-cell non-Hodgkin lymphoma. The first project is a a clinical audit report including a new audit tool for reviewing nursing assessments of cytokine release syndrome and immune effector cell neurotoxicity syndrome, two of the primary characteristic risks seen after CAR T-cell therapy. The second study, RE-TELL, is a qualitative research study of Aotearoa New Zealand CAR T-cell patients, support persons, clinicians and administrators, to identify future improvements in CAR T-cell delivery. Lastly, I present THERMAL, a study of wearable temperature monitors for the detection of neutropenic fevers, a key risk with CAR T-cell therapy. These three projects represent attempts to enhance the safe clinical delivery of CAR T-cell therapy for B-cell non-Hodgkin lymphoma, from the patient level to the service design level, which could be readily translated into CAR T-cell service delivery in the future, both in Aotearoa New Zealand and internationally.&lt;/strong&gt;&lt;/p&gt;", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.31219/osf.io/ckxh5", "doi": "10.31219/osf.io/ckxh5", "title": "Nonviral gene delivery vectors for transfection of the CAR gene for CAR-T cell therapy", "publicationYear": 2021, "publicationDate": "2021-06-12", "type": "posted-content", "publisher": "Center for Open Science", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Moataz Dowaidar", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.31219/osf.io/ckxh5", "pdfUrl": null, "abstract": "The introduction of the CAR gene via retrovirus is the most widely used and most successful technique for CAR-T cell therapy. However, the limitations and risks associated with viral gene therapy continue to motivate the development of nonviral gene delivery technologies that are potentially safer, less expensive, and quicker. In terms of safety and efficacy, electroporation has emerged as the most promising non-viral technology, albeit more optimization testing and clinical trials are required before it can be directly compared to retroviral CAR gene delivery techniques. But these findings suggest that non-viral gene delivery to T cells (and other related cells, such as natural killer cells) is feasible and is quickly emerging as a viable alternative to CAR-T cell therapy and other gene therapies.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.20944/preprints202109.0212.v1", "doi": "10.20944/preprints202109.0212.v1", "title": "An Overview of CAR T Cell Mediated B Cell Maturation Antigen Therapy", "publicationYear": 2021, "publicationDate": "2021-09-13", "type": "posted-content", "publisher": "MDPI AG", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Sameer Quazi", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.20944/preprints202109.0212.v1", "pdfUrl": null, "abstract": "Multiple Myeloma (MM) is one of the incurable types of cancer in plasma cells. While immense progress has been made in the treatment of this malignancy, a large percentage of patients were unable to adapt to such therapy. Additionally, these therapies might be associated with significant diseases and are not always tolerated well in all patients. Since cancer in plasma cells has no cure, patients develop resistance to treatments, resulting in R/R MM. BCMA is primarily produced on mature B cells. Its up-regulation and activation are associated with multiple myeloma in both murine and human models, indicating that this might be an effective therapeutic target for this type of malignancy. Additionally, BCMA's predictive value, association with effective clinical trials, and capacity to be utilized in previously difficult to observe patient populations, imply that it might be used as a biomarker for multiple myeloma. Numerous kinds of BCMA-targeting medicines have demonstrated antimyeloma efficacy in individuals with refractory/relapsed MM, including CAR T-cell treatments, ADCs, bispecific antibody constructs. Among these medications, CART cell-mediated BCMA therapy has shown significant outcomes in multiple myeloma clinical trials. This review article outlines CAR T cell mediated BCMA medicines have the efficiency to change the therapeutic pattern for multiple myeloma significantly.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.31219/osf.io/s4bf5", "doi": "10.31219/osf.io/s4bf5", "title": "The major advantages and early clinical obstacles of CAR-NK compared to CAR-T cell therapy", "publicationYear": 2023, "publicationDate": "2023-05-24", "type": "posted-content", "publisher": "Center for Open Science", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Chenyang Li", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/legalcode", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.31219/osf.io/s4bf5", "pdfUrl": null, "abstract": "Chimeric Antigen Receptor T-Cells (CAR-T) are genetically engineered T cells designed to recognize and attack specific cancer cells, thereby offering a targeted approach to cancer immunotherapy. Chimeric Antigen Receptor Natural Killer (CAR-NK) cells are a novel form of such cell therapy where NK cells are genetically modified to express specific receptors, enabling them to identify and eliminate targeted cancer cells. This mini-review discussed the major advantages of CAR-NK compared to CAR-T, issues that limit the clinical translation of CAR-NK cells, and approaches to overcome these early obstacles.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.17504/protocols.io.rdyd27w", "doi": "10.17504/protocols.io.rdyd27w", "title": "The Latest Research Progress of CAR-T Cell Therapy v1", "publicationYear": 2018, "publicationDate": "2018-06-29", "type": "posted-content", "publisher": "ZappyLab, Inc.", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Bella Smith", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.17504/protocols.io.rdyd27w", "pdfUrl": null, "abstract": "CAR-T (Chimeric Antigen Receptor T-Cell Immunotherapy), achimeric antigen receptor T cellimmunotherapy, has been in use for many years but has only been used in clinical practice in recent years. It has significant curative effect in the treatment of acute leukemia and non-Hodgkin'slymphoma,and is considered as one of the most promising approaches totreatmentof cancer. As with all technologies, CAR-T technology has also undergone a long evolutionary process. It is during this series of evolution that CAR-T technology has gradually matured.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.33540/3350", "doi": "10.33540/3350", "title": "Empowering CAR T Cell Therapy", "publicationYear": 2025, "publicationDate": "2025-12-17", "type": "dissertation", "publisher": "Utrecht University Library", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9789039379905, 9789039379905", "authors": "Thomas Kimman", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.33540/3350", "pdfUrl": null, "abstract": "Chimeric antigen receptors (CAR) T cell therapies have already demonstrated favourable clinical outcomes, however tumor resistance mechanisms remain a major obstacle. This thesis focuses on the primary function of CAR T cells in cancer therapy: the mechanisms by which they kill tumor cells. By gaining a fundamental understanding of how CAR T cells induce tumor cell death and how tumors resist this cytotoxicity, we can design new strategies to overcome resistance while avoiding systemic side effects. The main mechanism by which CAR T cells eliminate tumor cells is through the release of cytotoxic granule contents into the target cell. The key effector protein that induces regulated cell death (apoptosis) is granzyme B. In human biology, Serpin B9 is known as a specific inhibitor of granzyme B. Chapter 2 identifies Serpin B9 as a novel intrinsic resistance mechanism to CD19- and CD20-directed CAR T cell therapy. Previous studies have shown that preclinical inhibition of MCL-1 can effectively eliminate multiple myeloma (MM) cells. However, clinical trials have revealed severe systemic toxicity associated with MCL-1 inhibition, halting further clinical development. To make this potentially effective strategy feasible, we investigated synergistic combinations of clinically available agents. Chapter 3 demonstrates that inhibition of P70S6K1 and MCL-1 has a synergistic effect, thereby allowing treatment with lower doses of MCL-1 inhibitors and minimizing adverse effects. In Chapter 4, we explore innovative methods to specifically target MCL-1 in MM. To this end, we developed a strategy to express the MCL-1 antagonist NOXA within the cytotoxic granules of BCMA-targeted CAR T cells. We show that NOXA can be directed to the granules by fusing it to granzyme B. Upon recognition of an MM cell, NOXA is released into the tumor cell. This arming of BCMA CAR T cells with a pro-apoptotic NOXA, enhances their antitumor activity. Besides we also reveal MCL-1 expression by MM cells as a CAR T resistance mechanism. Chapter 5 describes an international patent filing related to fusion proteins based on the NOXA scaffold. In this approach, the effector BH3 domain of NOXA can be exchanged with BH3 domains from other pro-apoptotic BCL-2 family proteins. This design could support personalized therapies tailored to tumor-specific dependencies on survival proteins. Cytotoxic T cells mainly induce apoptosis. This clean form of cell death does not release inflammatory mediators such as damage-associated molecular patterns (DAMPs). In Chapter 6, we take the first steps toward using our CARgo delivery method to induce immunogenic cell death in vitro. We anticipate that inducing an immunogenic form of tumor cell death could shift the balance in favor of tumor-clearing CAR T cells, especially in solid tumor settings where T cell infiltration is limited. Collectively, this thesis provides new insights into intrinsic tumor resistance mechanisms involving Serpin B9 and MCL-1, and presents innovative strategies using CAR T cells to deliver pro-apoptotic or immunogenic cell death–inducing proteins to tumor cells. Together, these studies mark a step forward in overcoming resistance and advancing the next generation of CAR T cell therapies.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.70675/11e2363dzeb1fz46bcza38dz6f6c7aa5545d", "doi": "10.70675/11e2363dzeb1fz46bcza38dz6f6c7aa5545d", "title": "Developing logic-gated CAR T cells for saferT-cell lymphoma therapy", "publicationYear": 2026, "publicationDate": "2026-04-09", "type": "dissertation", "publisher": "Agence Bibliographique de l'Enseignement Supérieur", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Estelle Bourbon", "authorCount": 1, "firstAuthorAffiliation": "université Paris-Saclay", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.70675/11e2363dzeb1fz46bcza38dz6f6c7aa5545d", "pdfUrl": null, "abstract": "CAR T cells à circuits intégrés pour améliorer leur sécurité dans le traitement des lymphomes T La thérapie par cellules T à récepteur antigénique chimérique (CAR) est apparue comme l'une des percées les plus convaincantes dans le traitement du cancer au cours de la dernière décennie. Cependant, les résultats remarquables obtenus dans les hémopathies B ne se sont pas encore étendus aux lymphomes T (LT) où l'éventuelle toxicité « on-target off-tumor » a limité le développement d'approches similaires.Dans ce travail, nous avons développé une plateforme NOT-gate, tirant parti de la perte d'expression du CD7 dans les LT pour distinguer les cellules T tumorales des cellules T normales. Cette plateforme associe un CAR 4-28^1 XX activateur ciblant le CD4, un antigène T fortement exprimé dans les LT, à un CAR 7PD1 inhibiteur ciblant le CD7. Les nouvelles cellules CAR T 4-28(1XX, éditées CD4 pour limiter le fratricide, ont démontré une activité antitumorale robuste contre les cellules tumorales CD4-positives in vitro et in vivo dans des modèles murins de LT disséminé. Cependant, la perte du CD4 a démasqué un phenotype hyperproliferatif reponsable d'une infiltration tissulaire létale, dont les mécanismes exacts restent à élucider. L'ajout d'un CAR inhibiteur 7PD1 a permis de réduire la sécrétion de cytokines et la dégranulation des cellules T CAR4-28C1XX, mais il a été plus difficile d'obtenir une inhibition de la cytotoxicité globale. De nombreux paramètres doivent être optimisés pour une plateforme NOT- gate plus efficace, comprenant principalement le rapport stoechiométrique CAR/cible et l'intensité du signal médié par chaque CAR.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.4084/mjhid.2023.066", "doi": "10.4084/mjhid.2023.066", "title": "CAR-T CELL THERAPY IN LARGE B CELL LYMPHOMA", "publicationYear": 2023, "publicationDate": "2023-10-30", "type": "journal-article", "publisher": "Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy", "containerTitle": "Mediterranean Journal of Hematology and Infectious Diseases", "volume": "15", "issue": "1", "page": "e2023066", "issn": "2035-3006", "isbn": null, "authors": "Ugo Testa, Germana Castelli, Giuseppe Leone, Elvira Pelosi, Germana Castelli, Stefan Hohaus", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4084/mjhid.2023.066", "pdfUrl": "https://www.mjhid.org/index.php/mjhid/article/download/5517/4418", "abstract": "Large B-cell lymphomas (LBCLs) are among the most frequent (about 30%) non-Hodgkin’s lymphoma. Despite the aggressive behavior of these lymphomas, more than 60% of patients can be cured with first-line chemoimmunotherapy using the R-CHOP regimen. Patients with refractory or relapsing disease show a poor outcome even when treated with second-line therapies. CD19-targeted chimeric antigen receptor (CAR) T-cells are emerging as an efficacious second-line treatment strategy for patients with LBCL. Three CD19-CAR-T-cell products received FDA and EMA approval. The use of CAR-T cell therapy has also been explored for the treatment of high-risk LBCL patients in the first-line setting and for patients with central nervous system involvement. Although CD19-CAR-T therapy has transformed the care of refractory/relapsed LBCL, about 60% of these patients will ultimately progress or relapse following CD19-CAR-T: therefore, it is fundamental to identify predictive criteria of response to CAR-T therapy and to develop salvage therapies for patients relapsing after CD19-CAR-T therapies. Moreover, ongoing clinical trials are evaluating bispecific CAR-T cells targeting both CD19 and CD20 or CD19 and CD22 as a tool to improve the therapeutic efficacy and to reduce the number of refractory/relapsing patients.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.20944/preprints202503.1800.v1", "doi": "10.20944/preprints202503.1800.v1", "title": "CAR T Cell Therapy for Rheumatoid Arthritis", "publicationYear": 2025, "publicationDate": "2025-03-25", "type": "posted-content", "publisher": "MDPI AG", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Michael Freeley", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.20944/preprints202503.1800.v1", "pdfUrl": null, "abstract": "Chimeric Antigen Receptor (CAR) T cell therapy had revolutionised the treatment of relapsed/refractory B cell leukaemia, lymphoma and multiple myeloma. A growing body of evidence has recently demonstrated that these cell-based therapies can target autoimmune diseases including systemic lupus erythematosus, systemic sclerosis and Rheumatoid Arthritis. This review highlights how CAR T cell therapy has been used to treat Rheumatoid Arthritis patients with treatment refractory disease. To date, seven patients have been treated with CAR T cells targeting CD19 and/or CD20 antigens on B cells, and all patients have shown remarkable responses, including depletion of circulating B cells, ablation of autoantibody levels and drug-free remission. The review also highlights emerging in-vitro and animal model studies where T cell subsets have been engineered with CARs to fine-tune their immune responses, including targeting of autoreactive B cells, autoreactive T cells or fibroblasts. CAR T cell therapy holds enormous promise for the treatment of difficult-to-treat Rheumatoid Arthritis, but more research and clinical trials are needed to confirm its efficacy and safety.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.61173/b3sbkj31", "doi": "10.61173/b3sbkj31", "title": "CAR-T Cell Therapy in Primary Mediastinal B-cell Lymphoma", "publicationYear": 2025, "publicationDate": "2025-10-23", "type": "journal-article", "publisher": "Dean & Francis Press", "containerTitle": "MedScien", "volume": "1", "issue": "5", "page": null, "issn": "2960-1290", "isbn": null, "authors": "Fangzi Liu", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.61173/b3sbkj31", "pdfUrl": "https://lseee.net/index.php/ms/article/download/965/MS004792.pdf", "abstract": "A specific type of CAR-T cell therapy, the CAR19 therapy has demonstrated notable efficacy for relapsed or refractory (R/R) hematologic cancers, including B-cell lymphomas. After the recent reclassification of the rare subtype Primary Mediastinal B-cell Lymphoma (PMBCL) from general Diffuse Large B-cell Lymphoma (DLBCL), questions have been raised about the application of immunotherapies in this cancer, including the most discussed CAR-T cell therapy. The CAR-T cell therapy, more specifically the CAR19, exerts anti-tumor effects in multiple mechanisms, including different cytotoxic pathways—apoptosis triggering via perforin–granzyme release and Fas/FasL-pathway—driven by calcium-dependent signaling MAPK, PI3K/Akt, and NF-κB. Multiple extant clinical trials have evaluated the response of PMBCL patients to CAR19, specifically the Axi-cel, Liso-cel, and Tisa-cel therapies, focusing the rates of complete response (CR), progression-free survival (PFS), and the overall survival (OS). Studies exclusive to PMBCL patients showed that bridging therapies and other first-line treatments did not influence CAR19 effectiveness, while post-relapse application of Pembrolizumab yielded durable CRs in some patients, and allo-HSCT was associated with high mortality. The CAR-SIE trial in Italy, comparing Axi-cel CAR19 in PMBCL cancer with other B-cell lymphomas, demonstrated a better result in PMBCL patients with higher ORR, CR, and PFS. This paper integrates the underlying mechanisms of CAR19 with clinical trials, aiming to demonstrate both the potential and the limitations of this therapy in PMBCL cancer.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1101/2020.06.20.162925", "doi": "10.1101/2020.06.20.162925", "title": "Modelling CAR T-cell Therapy with Patient Preconditioning", "publicationYear": 2020, "publicationDate": "2020-06-20", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Katherine Owens, Ivana Bozic", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1101/2020.06.20.162925", "pdfUrl": null, "abstract": "A bstract The Federal Drug Administration (FDA) approved the first Chimeric Antigen Receptor T-cell (CAR T-cell) therapies for the treatment of several blood cancers in 2017, and efforts are underway to broaden CAR T technology to address other cancer types. Standard treatment protocols incorporate a preconditioning regimen of lymphodepleting chemotherapy prior to CAR T-cell infusion. However, the connection between preconditioning regimens and patient outcomes is still not fully understood. Optimizing patient preconditioning plans and reducing the CAR T-cell dose necessary for achieving remission could make therapy safer. In this paper, we test treatment regimens consisting of sequential administration of chemotherapy and CAR T-cell therapy on a system of differential equations that models the tumor-immune interaction. We use numerical simulations of treatment plans from within the scope of current medical practice to assess the effect of preconditioning plans on the success of CAR T-cell therapy. Model results affirm clinical observations that preconditioning can be crucial for some patients, not just to reduce side effects, but to even achieve remission at all. We demonstrate that preconditioning plans using the same CAR T-cell dose and the same total concentration of chemotherapy can lead to different patient outcomes due to different delivery schedules. Results from sensitivity analysis of the model parameters suggest that making small improvements in the effectiveness of CAR T-cells in attacking cancer cells, rather than targeting the recruitment and longevity of CAR T-cells, will significantly reduce the minimum dose required for successful treatment. Our modeling framework represents a starting point for evaluating the efficacy of patient preconditioning in the context of CAR T-cell therapy.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.23880/beba-16000163", "doi": "10.23880/beba-16000163", "title": "Chimeric Antigen Receptor T-Cell Therapy (Car T-Cells) in Solid Tumors, Resistance and Success", "publicationYear": 2022, "publicationDate": "2022", "type": "journal-article", "publisher": "Medwin Publishers", "containerTitle": "Bioequivalence &amp; Bioavailability International Journal", "volume": "6", "issue": "1", "page": "1-6", "issn": "2578-4803", "isbn": null, "authors": "Elshimali Y", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.23880/beba-16000163", "pdfUrl": "https://medwinpublishers.com/BEBA/chimeric-antigen-receptor-t-cell-therapy-car-t-cells-in-solid-tumors-resistance-and-success.pdf", "abstract": "CARs are chimeric synthetic antigen receptors that can be introduced into an immune cell to retarget its cytotoxicity toward a specific tumor antigen. CAR T-cells immunotherapy demonstrated significant success in the management of hematologic malignancies. Nevertheless, limited studies are present regarding its efficacy in solid and refractory tumors. It is well known that the major concerns regarding this technique include the risk of relapse and the resistance of tumor cells, in addition to high expenses and limited affordability. Several factors play a crucial role in improving the efficacy of immunotherapy, including tumor mutation burden (TMB), microsatellite instability (MSI), loss of heterozygosity (LOH), the APOBEC Protein Family, tumor microenvironment (TMI), and epigenetics. In this minireview, we address the current and future applications of CAR T-Cells against solid tumors and their measure for factors of resistance and success.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.18609/cgti.2025.013", "doi": "10.18609/cgti.2025.013", "title": "Enhancing CAR-T therapy development: harnessing cell selection flexibility", "publicationYear": 2025, "publicationDate": "2025-02-06", "type": "journal-article", "publisher": "BioInsights Publishing, Ltd.", "containerTitle": "Cell and Gene Therapy Insights", "volume": "11", "issue": "1", "page": "111–123", "issn": "2059-7800", "isbn": null, "authors": "Tamara Laskowski, Nuala Trainor", "authorCount": 2, "firstAuthorAffiliation": "Lonza, Houston, TX, USA", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.18609/cgti.2025.013", "pdfUrl": null, "abstract": "Clinical advancements in personalized cell therapy, particularly CAR-T cell therapy, have created a demand for innovative, closed, automated, and space-efficient manufacturing methods. Given that each therapeutic product requires a unique manufacturing process, flexibility in automation platforms is essential to accommodate these varying needs. This article will explore recent developments in the Cocoon® Platform, an automated system for CAR-T manufacturing, highlighting the ability to adapt to different processes including positively or negatively selecting T cells directly from apheresis. Enabling direct cell isolation from the input material eliminates the need for additional upstream processing equipment, thus reducing costs, time, and space requirements. Automatic transfer to an expansion chamber for extended culture enables further reduction in manual processing.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.4084/mjhid.2024.031", "doi": "10.4084/mjhid.2024.031", "title": "CAR-T CELL THERAPY FOR T-CELL MALIGNANCIES", "publicationYear": 2024, "publicationDate": "2024-02-29", "type": "journal-article", "publisher": "Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy", "containerTitle": "Mediterranean Journal of Hematology and Infectious Diseases", "volume": "16", "issue": "1", "page": "e2024031", "issn": "2035-3006", "isbn": null, "authors": "Ugo Testa, Patrizia Chiusolo, Elvira Pelosi, Germana Castelli, Giuseppe Leone", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4084/mjhid.2024.031", "pdfUrl": "https://www.mjhid.org/mjhid/article/download/5633/4493", "abstract": "Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of B-cell lymphoid neoplasia and, in some instances, improved disease outcomes. Thus, six FDA-approved commercial CAR-T cell products that target antigens preferentially expressed on malignant B-cells or plasma cells have been introduced in the therapy of B-cell lymphomas, B-ALLs and multiple myeloma. These therapeutic successes have triggered the application of CAR-T cell therapy to other hematologic tumors, including T-cell malignancies. However, the success of CAR-T cell therapies in T-cell neoplasms was considerably more limited to the existence of some limiting factors, such as the sharing of mutual antigens between normal T-cells and CAR-T cells, and malignant cells, determining fratricide events and severe T-cell aplasia; contamination of CAR-T cells used for CAR transduction with contaminating malignant T-cells. Allogeneic CAR-T products can avoid tumor contamination but raise other problems related to immunological incompatibility. In spite of these limitations, there has been significant progress in CD7- and CD5-targeted CAR-T cell therapy of T-cell malignancies in the last few years.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.70675/580ab96fzaff1z4acfz8156z822dc6e5f3d7", "doi": "10.70675/580ab96fzaff1z4acfz8156z822dc6e5f3d7", "title": "Defining the differential contributions of CD4+ and CD8+ T cells to CAR T cell therapy against B cell malignancies", "publicationYear": 2026, "publicationDate": "2026-04-07", "type": "dissertation", "publisher": "Agence Bibliographique de l'Enseignement Supérieur", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Morgane Boulch", "authorCount": 1, "firstAuthorAffiliation": "Université Paris Cité", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.70675/580ab96fzaff1z4acfz8156z822dc6e5f3d7", "pdfUrl": null, "abstract": "Définir les contributions différentielles des lymphocytes T CD4+ et CD8+ à la thérapie par cellules CAR T contre les cancers hématologiques Les cellules CAR T (de l'anglais Chimeric Antigen Receptor T cells) sont apparues comme étant une thérapie potentiellement curative pour le traitement de certains lymphomes et leucémies. Au cours d'essais cliniques, les cellules CAR T anti-CD19 ont atteint des taux de rémission initiaux allant jusqu'à 86%, mais seuls 50% des patients ayant une réponse durable à long terme. La survenue d'événements indésirables graves, dont le syndrome de relargage des cytokines (CRS), représente une limitation importante à la thérapie par cellules CAR T. Les produits de cellules CAR T comprennent un mélange de lymphocytes T CD4+ et CD8+ et ainsi diffèrent grandement d'un patient à l'autre avec, notamment, d'importantes différences dans la représentation des divers phénotypes de lymphocytes T. Le succès de la thérapie par cellules CAR T est généralement attribué à l'activité d'un grand nombre d'effecteurs cytotoxiques ciblant la tumeur. Par conséquent, nous ne savons pas précisément si les cellules CAR T agissent de manière autonome ou si elles nécessitent des interactions avec le microenvironnement tumoral. Dans la littérature, les cellules CD4+ CAR T présentent une activité anti-tumorale variable selon les modèles précliniques. Ainsi, les mécanismes qui déterminent quand et comment les cellules CD4+ CAR T favorisent la régression tumorale ne sont pas complètement compris. Enfin, nous ne savons pas si la variabilité interindividuelle de la composition des cellules CAR T contribue au développement du CRS. Durant mon doctorat, j'ai étudié le mode d'action et les contributions différentielles des cellules CD4+ et CD8+ CAR T à l'efficacité anti-tumorale et aux toxicités liées à la thérapie dans le contexte d'hémopathies lymphoïdes B. En utilisant le séquençage des ARN de cellules uniques, nous avons montré que la thérapie par cellules CAR T induit un remodelage considérable du microenvironnement tumoral. La production d'interféron-g (IFN-g) par les cellules CAR T puis la production subséquente d'interleukine 12 (IL-12) par les cellules hôtes ont non seulement renforcé l'activité des lymphocytes T et NK endogènes, mais ont également été essentiels au maintien de la cytotoxicité des cellules CAR T. En comparaison des cellules CD8+ CAR T, les cellules CD4+ CAR T sont très efficaces pour l'activation immunitaire endogène mais présentent une activité cytotoxique moindre. À l'aide de l'imagerie intravitale biphotonique, nous avons mis en évidence que la production d'IFN-g, plutôt que la cytotoxicité médiée par la perforine, était le mécanisme dominant pour l'élimination tumorale par les cellules CD4+ CAR T. Mécaniquement, l'IFN-g dérivé des cellules CD4+ CAR T est capable de diffuser largement pour agir sur les cellules tumorales à distance, tuant sélectivement les tumeurs sensibles à la mort induite par cytokine. La sensibilité intrinsèque de la tumeur à l'activité pro-apoptotique de l'IFN-g est donc un déterminant majeur de l'efficacité des lymphocytes CD4+ CAR T. Enfin, nous montrons que les cellules CD4+ CAR T, mais pas les cellules CD8+ CAR T, sont principalement responsables du CRS. Notamment, le CRS s'est développé indépendamment de l'IFN-g produit par les cellules CAR T, et uniquement en condition de charge tumorale élevée. En ce sens, nous proposons que l'ajustement du ratio de cellules CD4:CD8 CAR T à la charge tumorale du patient permette d'atténuer les toxicités associées aux cellules CAR T. En conclusion, les cellules CAR T n'agissent pas seules in vivo, mais reposent plutôt sur des interactions cellulaires et moléculaires au sein du microenvironnement tumoral pour leur efficacité optimale et éliminent les cellules tumorales à travers plusieurs mécanismes complémentaires. Identifier et tirer parti des forces et des faiblesses uniques des cellules CD4+ et CD8+ CAR T représentent une étape importante vers la conception rationnelle de thérapies cellulaires améliorées tout en atténuant les toxicités associées aux cellules CAR T.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.3324/haematol.2026.300761", "doi": "10.3324/haematol.2026.300761", "title": "Unmasking the invisible: CAR T-cell therapy for intravascular large B-cell lymphoma", "publicationYear": 2026, "publicationDate": "2026-03-12", "type": "journal-article", "publisher": "Ferrata Storti Foundation (Haematologica)", "containerTitle": "Haematologica", "volume": null, "issue": null, "page": null, "issn": "1592-8721, 0390-6078", "isbn": null, "authors": "Irit Avivi", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3324/haematol.2026.300761", "pdfUrl": "https://haematologica.org/article/download/13395/79788", "abstract": "Not available.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.61173/ccs0h933", "doi": "10.61173/ccs0h933", "title": "CAR-T Cell Therapy in Acute Lymphoblastic Leukemia", "publicationYear": 2025, "publicationDate": "2025-10-23", "type": "journal-article", "publisher": "Dean & Francis Press", "containerTitle": "MedScien", "volume": "1", "issue": "5", "page": null, "issn": "2960-1290", "isbn": null, "authors": "Chenyu Li", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.61173/ccs0h933", "pdfUrl": "https://lseee.net/index.php/ms/article/download/1040/MS005322.pdf", "abstract": "Acute Lymphoblastic Leukemia (ALL) is a common blood malignancy tumor that originates from the uncontrolled growth of immature lymphocytes. This process destabilizes normal hematopoiesis and gradually deteriorates the health of patients. There are some conventional treatments such as chemotherapy and hematopoietic stem cell transplantation can improve survival for some patients. However, regarding Relapsed or Refractory (R/R) cases, their efficacy remains very limited, which is a significant challenge in clinical practice. To address these challenges, Chimeric Antigen Receptor T-cell (CAR-T) therapy has unveiled an innovative immunotherapeutic therapy. By carrying out genetic engineering on autologous T cells of patients, this strategy allows them to accurately identify and eradicate malignant lymphoblasts. Among these strategies, CD19-directed CAR-T therapy has accomplished notable clinical breakthroughs. Research shows that 70% to 90% of patients suffering from R/R ALL achieve total remission after receiving CAR-T therapy. In most cases, minimal residual disease becomes undetectable within a relatively short period. These findings also reflect this therapy can induce rapid remission and offer patients improved long-term survival outlook. At the same time, research in this field is expanding. But, in relation to safety hurdles including Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS), the risk of relapse in certain patients, and the logistical challenges posed by complex manufacturing and high costs. This research explores recent research on CAR-T therapy in ALL, highlighting both its treatment developments and existing limitations. The purpose is to provide a thorough understanding that may advise future clinical practice and translational research.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1126/scitranslmed.abn3353", "doi": "10.1126/scitranslmed.abn3353", "title": "B cell targeting in CAR T cell therapy: Side effect or driver of CAR T cell function?", "publicationYear": 2022, "publicationDate": "2022-06-22", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science Translational Medicine", "volume": "14", "issue": "650", "page": null, "issn": "1946-6234, 1946-6242", "isbn": null, "authors": "Gregory M. Chen, Jan Joseph Melenhorst, Kai Tan", "authorCount": 3, "firstAuthorAffiliation": "Graduate Group in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA, USA.", "isReferencedByCount": 20, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/scitranslmed.abn3353", "pdfUrl": null, "abstract": "Chimeric antigen receptor (CAR) T cell therapies targeting CD19 and CD22 have been successful for treating B cell cancers, but CAR T cells targeting non–B cell cancers remain unsuccessful. We propose that rather than being strictly a side effect of therapy, the large number of CAR interactions with normal B cells may be a key contributor to clinical CAR T cell responses.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.18609/cgti.2025.107", "doi": "10.18609/cgti.2025.107", "title": "Bridging viral immunology and CAR-T therapy: leveraging natural T cell responses to enhance engineered cell therapies", "publicationYear": 2025, "publicationDate": "2025-09-03", "type": "journal-article", "publisher": "BioInsights Publishing, Ltd.", "containerTitle": "Cell and Gene Therapy Insights", "volume": "11", "issue": "8", "page": "971–977", "issn": "2059-7800", "isbn": null, "authors": "Catherine Bollard", "authorCount": 1, "firstAuthorAffiliation": "Senior Vice President and Chief Research Officer, Children’s National Hospital, Washington, DC USA", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.18609/cgti.2025.107", "pdfUrl": null, "abstract": "“Success ultimately requires thoughtful clinical trial design that evaluates how...immunoengineered products...perform against exhaustion and TME suppression in comparable patient populations.” Ashling Cannon (Editor, BioInsights) speaks to Catherine Bollard (Chief Research Officer and Senior Vice President, Children’s National Hospital) about translating insights from natural viral antigen-specific T cell responses into improved CAR-T design and clinical performance. They explore how virus-specific T cells demonstrate superior persistence compared to current CAR-T therapies, strategies for preventing T cell exhaustion through TGF-beta resistance, innovative combination approaches merging antigen-specific T cells with CAR-T platforms, and critical regulatory considerations for advancing these therapeutic approaches from bench to clinic.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1186/s13287-021-02595-0", "doi": "10.1186/s13287-021-02595-0", "title": "CAR-T cell therapy in T-cell malignancies: Is success a low-hanging fruit?", "publicationYear": 2021, "publicationDate": "2021-10-07", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Stem Cell Research &amp; Therapy", "volume": "12", "issue": "1", "page": null, "issn": "1757-6512", "isbn": null, "authors": "Pouya Safarzadeh Kozani, Pooria Safarzadeh Kozani, Fatemeh Rahbarizadeh", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 65, "referenceCount": 142, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1186/s13287-021-02595-0", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s13287-021-02595-0.pdf", "abstract": "AbstractChimeric antigen receptor T-cell (CAR-T) therapy has been prosperous in the treatment of patients with various types of relapsed/refractory (R/R) B-cell malignancies including diffuse large B-cell lymphoma (DLBCL), B-cell acute lymphoblastic leukemia (B-ALL), follicular lymphoma (FL), mantle cell lymphoma (MCL), and multiple myeloma (MM). However, this type of therapy has faced serious hindrances in combating T-cell neoplasms. R/R T-cell malignancies are generally associated with poor clinical outcomes, and the available effective treatment approaches are very limited. CAR-T therapy of T-cell malignancies has unique impediments in comparison with that of B-cell malignancies. Fratricide, T-cell aplasia, and product contamination with malignant T cells when producing autologous CAR-Ts are the most important challenges of CAR-T therapy in T-cell malignancies necessitating in-depth investigations. Herein, we highlight the preclinical and clinical efforts made for addressing these drawbacks and also review additional potent stratagems that could improve CAR-T therapy in T-cell malignancies.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.20944/preprints202304.0482.v1", "doi": "10.20944/preprints202304.0482.v1", "title": "The Black Hole: CAR T cell Therapy in AML", "publicationYear": 2023, "publicationDate": "2023-04-18", "type": "posted-content", "publisher": "MDPI AG", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Erden Atilla, Karim Benabdellah", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 11, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.20944/preprints202304.0482.v1", "pdfUrl": null, "abstract": "Despite exhaustive studies, researchers have made little progress in the field of adoptive cellular therapies for relapsed-refractory acute myeloid leukemia (AML), unlike the notable uptake for B cell malignancies. Various single antigen targeting chimeric antigen receptor (CAR) T cell Phase I trials have been established worldwide and have recruited approximately 100 patients. The high heterogeneity at the genetic and molecular levels within and between AML patients resembles a black hole: a great gravitational field that sucks in everything, considering only around 30% of patients show a response but with consequential off-tumor effects. It is obvious that a new point of view is needed to achieve more promising results. This review first introduces the unique therapeutic challenges of not only CAR T cells but also other adoptive cellular therapies in AML. Next, recent single cell sequencing data for AML to assess somatically acquired alterations at the DNA, epigenetic, RNA and protein levels are discussed to give a perspective on cellular heterogeneity, intercellular hierarchies, and the cellular ecosystem. Finally, promising novel strategies are summarized, including more sophisticated next-generation CAR T, TCR-T and CAR-NK therapies; approaches to tailor the microenvironment and target neoantigens; and allogeneic approaches.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.3324/haematol.2026.301607", "doi": "10.3324/haematol.2026.301607", "title": "Separating dose schedule from disease biology in CD19 CAR T-cell therapy. Comment on: \"A novel dose-dense strategy for CD19-directed CAR T-cell therapy is associated with durable responses without increased toxicity in patients with B-cell non-Hodgkin lymphoma\"", "publicationYear": 2026, "publicationDate": "2026-07-23", "type": "journal-article", "publisher": "Ferrata Storti Foundation (Haematologica)", "containerTitle": "Haematologica", "volume": null, "issue": null, "page": null, "issn": "1592-8721, 0390-6078", "isbn": null, "authors": "Yushan Jin, Yuan Fang, Yao Yao", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3324/haematol.2026.301607", "pdfUrl": "https://haematologica.org/article/download/14320/80643", "abstract": "Not available.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1001/jama.2023.27885", "doi": "10.1001/jama.2023.27885", "title": "T-Cell Lymphoma From CAR T-Cell Therapy—A New Safety Notice", "publicationYear": 2024, "publicationDate": "2024-02-06", "type": "journal-article", "publisher": "American Medical Association (AMA)", "containerTitle": "JAMA", "volume": "331", "issue": "5", "page": "389", "issn": "0098-7484", "isbn": null, "authors": "Vinay Prasad", "authorCount": 1, "firstAuthorAffiliation": "Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco", "isReferencedByCount": 13, "referenceCount": 7, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1001/jama.2023.27885", "pdfUrl": "https://jamanetwork.com/journals/jama/articlepdf/2814077/jama_prasad_2024_vp_230165_1706898115.66206.pdf", "abstract": "This Viewpoint outlines a recent safety signal identified by the FDA concerning CAR T-cell therapy for pediatric cancer, including what is known and likely implications.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1182/blood-2023-190167", "doi": "10.1182/blood-2023-190167", "title": "Exploring BiTE-Integrated CAR T-Cell Therapy to Overcome Tumor Antigen Escape and Reinforce CAR-T Therapy in Mantle Cell Lymphoma", "publicationYear": 2023, "publicationDate": "2023-11-02", "type": "journal-article", "publisher": "American Society of Hematology", "containerTitle": "Blood", "volume": "142", "issue": "Supplement 1", "page": "6820-6820", "issn": "0006-4971, 1528-0020", "isbn": null, "authors": "Grace Glass Crutchfield, Yang Liu, Fangfang Yan, Xiaolin Li, Heng-Huan Lee, Michael Wang, Yixin Yao", "authorCount": 7, "firstAuthorAffiliation": "1Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX", "isReferencedByCount": 4, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1182/blood-2023-190167", "pdfUrl": "https://ashpublications.org/blood/article-pdf/142/Supplement%201/6820/2190399/blood-3416-main.pdf", "abstract": "Background T cell engagers (BiTEs) are bispecific T-cell engaging antibodies that redirect T cells to target antigen-expressing tumor cells. Combining a second antigen-targeted bispecific T cell engager (BiTE) with CAR T cells or incorporating bispecific engaging antibody-secreting T cells (engager-T cells) is expected to augment T-cell activation and proliferative capacity, and antitumor cytotoxicity, even towards tumor cells expressing tumor antigens heterogeneously. Here, we report a BiTE-integrated T-cell therapeutic strategy to overcome tumor antigen escape and reinforce the efficacy of CAR-T therapy in mantle cell lymphoma (MCL). Methods CD20-directed bispecific T-cell engager (CD20-BiTE) was constructed with a publicly available VHH fragment from an anti-CD20 single-domain antibody, and anti-CD3 scFv from OKT3 monoclonal antibody. CD19-directed CAR construct is comprised of anti-CD19 scFv from publicly available FMC63 monoclonal antibody, CD8 transmembrane-, 4-1BB costimulatory-, and CD3ζ signaling-domains. Human primary pan-T cells were isolated from PBMC derived from normal human donors (MD Anderson Blood Bank) or patients with MCL. Activated T cells were used for effector functional assay or transduced with lentivirus to produce CAR T or engager-T cells. Effector function of bispecific antibodies and T cells was determined via T-cell activation, cytokine release, and T-cell-dependent cytotoxicity assay in a co-culture model. Results Treatment with CD20-BiTE enhances the effector function of naïve T cells: the BiTE-Fc fusion protein was ectopically expressed in Expi293 and purified by immobilized Protein-A. The binding specificity of scFv(s) of CD20-BiTE was confirmed to bind strongly and specifically to CD20-expressing cells. In vitro functional analyses demonstrated that co-culture of naïve T cells with CD20-exressing cells in the presence of CD20-BiTE induced antigen-specific activation of the T cells (increase in the expression of CD25 and CD69). In the presence of naïve T cells and antigen-positive MCL cells, CD20-BiTE enhanced the secretion of cytokines (IFNγ and TNFα, &amp;gt; 2-fold increase) and CD8 T-cell cytotoxic molecule granzyme B by T cells, in a BiTE-dependent and CD20-specific manner. The enhanced effector function translated into improved antitumor cytotoxicity, as activated T cells treated with CD20-BiTE exerted 43- 72% increase in the killing efficacy of JeKo-1 BTK-KD cells. CD20-BiTE-combined CAR T cells endowed with enhanced antitumor activity overcome tumor antigen escape and resistance to current CD19-CAR T cell therapy: when primary T cells and CD19-CAR T cells were co-cultured with MCL cells, addition of CD20-BiTE potentiated T cell-dependent cytotoxicity ( p &amp;lt; 0.001). Since both CD19-dependent and -independent CAR T cell-resistance often develop during adoptive cell therapy in MCL, we sought to overcome the resistance in MCL by combining a second antigen-targeted CD20-BiTE with CAR T cells or incorporating CD20-BiTE secreting T cells (engager-T cells). Remarkably, when combined with CD19-CAR T cells, CD20-BiTE mediates significant increase in the antitumor cytotoxicity, compared to T cells alone ( p ≤ 0,001 and p &amp;lt; 0.001 for 2nM and 5nM of the BiTE, respectively), in a CD20-specific fashion, in both MCL cells with diminished CD19 expression, and CD19-CAR T-resistant primary MCL cells. Importantly, in a transwell assay, CD19-CAR T cells demonstrated restored potent killing (&amp;gt;3-fold increase over CAR T cells alone) of the CD19-low or CAR T therapy resistant tumor cells, but only when the engager-T cells were present in the insert, suggesting the engaging molecules were able to redirect CD19-CAR T cells to CD20-positive tumor cells regardless of their CD19 expression. The anti-lymphoma efficacy of engager-CAR T cell therapy will be further evaluated in our well-established unique PDX model for MCL. In summary, we have successfully generated a CD20-directed bispecific T-cellengaging antibody and CD20-BiTE engager-T cells that could be combined with CAR T cell therapy, which was demonstrated effective in overcoming tumor antigen escape and resistance to current CD19-CAR T cell therapy in MCL.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.18609/cgti.2025.009", "doi": "10.18609/cgti.2025.009", "title": "Toward clinical-scale nonviral gene-edited CAR-NK cells for cell therapy", "publicationYear": 2025, "publicationDate": "2025-02-13", "type": "journal-article", "publisher": "BioInsights Publishing, Ltd.", "containerTitle": "Cell and Gene Therapy Insights", "volume": "11", "issue": "1", "page": "69–84", "issn": "2059-7800", "isbn": null, "authors": "Namritha Ravinder, Krishanu Saha", "authorCount": 2, "firstAuthorAffiliation": "Director, R&D, Cell Biology, Thermo Fisher Scientific, Carlsbad, CA, USA", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.18609/cgti.2025.009", "pdfUrl": null, "abstract": "Improving the accessibility and effectiveness of cell therapies is essential to meet the growing demand for cancer treatments. Engineered natural killer (NK) cells represent a promising modality, offering safety, effectiveness, and the possibility of allogeneic use. This article highlights gene editing techniques such as CRISPR-Cas9 for enhancement of NK cell functionality, and explores nonviral transfection methods and scalable manufacturing processes. Additionally, a case study on anti-Meso3 CAR-NK cells targeting ovarian cancer cell line is explored, showcasing the enhanced efficacy of engineered CAR-NK cells for killing cancer cells and their potential for clinical scale applications.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1038/s41434-021-00246-w", "doi": "10.1038/s41434-021-00246-w", "title": "Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany", "publicationYear": 2021, "publicationDate": "2021-09", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Gene Therapy", "volume": "28", "issue": "9", "page": "513-527", "issn": "0969-7128, 1476-5462", "isbn": null, "authors": "Nawid Albinger, Jessica Hartmann, Evelyn Ullrich", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 207, "referenceCount": 100, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "Deutsche Forschungsgemeinschaft", "funderIds": "10.13039/501100001659", "url": "https://doi.org/10.1038/s41434-021-00246-w", "pdfUrl": "https://www.nature.com/articles/s41434-021-00246-w.pdf", "abstract": "AbstractChimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. Lately, CAR-NK cell therapies have also come into focus as novel therapeutic options to address hurdles related to CAR-T cell therapies, such as therapy-induced side effects. Currently, more than 500 CAR-T and 17 CAR-NK cell trials are being conducted worldwide including the four CAR-T cell products Kymriah, Yescarta, Tecartus and Breyanzi, which are already available on the market. Most CAR-T cell-based gene therapy products that are under clinical evaluation consist of autologous enriched T cells, whereas CAR-NK cell-based approaches can be generated from allogeneic donors. Besides modification based on a second-generation CAR, more advanced CAR-immune cell therapeutics are being tested, which utilize precise insertion of genes to circumvent graft-versus-host disease (GvHD) or employ a dual targeting approach and adapter CARs in order to avoid therapy resistance caused by antigen loss. In this review, we are going to take a closer look at the commercial CAR-T cell therapies, as well as on CAR-T and CAR-NK cell products, which are currently under evaluation in clinical trials, that are being conducted in Germany.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.70675/328eb98ez91a1z4d34z858bz1e70d0709083", "doi": "10.70675/328eb98ez91a1z4d34z858bz1e70d0709083", "title": "Employing the tumor microenvironment to regulate CAR expression in engineered lymphocytes for safer cell therapy", "publicationYear": 2026, "publicationDate": "2026-04-08", "type": "dissertation", "publisher": "Agence Bibliographique de l'Enseignement Supérieur", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Enzo Manchon", "authorCount": 1, "firstAuthorAffiliation": "Université Paris Cité", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.70675/328eb98ez91a1z4d34z858bz1e70d0709083", "pdfUrl": null, "abstract": "Exploitation du microenvironnement tumoral pour réguler l'expression du CAR dans les lymphocytes génétiquement modifiés pour une thérapie cellulaire sécurisée Résumé non disponible", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1177/10430342261467645", "doi": "10.1177/10430342261467645", "title": "CAR-T Cell Therapy: Manufacturing Platforms and Clinical Consequences", "publicationYear": 2026, "publicationDate": "2026-07-10", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Human Gene Therapy", "volume": null, "issue": null, "page": null, "issn": "1043-0342, 1557-7422", "isbn": null, "authors": "Duc-Hiep Bach, Thanh Liem Nguyen", "authorCount": 2, "firstAuthorAffiliation": "Vinmec Research Institute of Stem Cell and Gene Technology, College of Health Sciences, VinUniversity, Hanoi, Vietnam.", "isReferencedByCount": 0, "referenceCount": 56, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/10430342261467645", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/10430342261467645", "abstract": "Chimeric antigen receptor (CAR) T-cell therapy has transformed hematological cancer care, yet variability in efficacy, durability, and safety cannot be explained solely by antigen selection or patient factors. We propose that manufacturing platforms are active biological determinants of outcome. Viral vectors, used in all licensed products, provide stable genomic integration and durable expression but are limited by cost, cargo capacity, and centralized production. Nonviral strategies, including transposons, CRISPR knock-ins, and messenger RNA delivery, enable faster, less-expensive manufacturing with larger payloads, while introducing distinct safety and persistence profiles. This review presents a three-layer mechanistic framework that reframes manufacturing as biology: integration biology determines genomic risk and transgene stability; clonal fitness shapes persistence, dominance, and exhaustion; and epigenomic imprinting, influenced by gene transfer method, cytokines, and culture stress, preconfigures functional trajectories. Clinical observations link platform choice to immune recovery, where prolonged B-cell aplasia and delayed T-cell reconstitution contribute to infection-related nonrelapse mortality, and hematopoietic reserve at apheresis emerges as a practical predictor. Finally, manufacturing is positioned as the key to democratizing cell therapy. Decentralized, nonviral production aligned with regulatory standards may enable equitable access and transition CAR-T therapy from innovation to sustainable global care.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1158/2159-8290.cd-nb2017-040", "doi": "10.1158/2159-8290.cd-nb2017-040", "title": "CRISPR Meets CAR T-cell Therapy", "publicationYear": 2017, "publicationDate": "2017-05-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Discovery", "volume": "7", "issue": "5", "page": "OF6-OF6", "issn": "2159-8274, 2159-8290", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/2159-8290.cd-nb2017-040", "pdfUrl": "https://aacrjournals.org/cancerdiscovery/article/7/5/OF6/6340/CRISPR-Meets-CAR-T-cell-TherapyCRISPR-Meets-CAR-T", "abstract": "Abstract Using CRISPR/Cas9 technology, researchers have devised a method to deliver a CAR gene to a specific locus, TRAC, in T cells. This targeted approach yielded therapeutic cells that were more potent even at low doses; in a mouse model of acute lymphoblastic leukemia, they outperformed CAR T cells created with a randomly integrating retroviral vector.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.3390/v15091793", "doi": "10.3390/v15091793", "title": "CAR-T Cell Therapy for HIV Cure", "publicationYear": 2023, "publicationDate": "2023-08-23", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Viruses", "volume": "15", "issue": "9", "page": "1793", "issn": "1999-4915", "isbn": null, "authors": "Maria Salgado", "authorCount": 1, "firstAuthorAffiliation": "AIDS Research Institute, IrsiCaixa, 08916 Barcelona, Spain", "isReferencedByCount": 3, "referenceCount": 4, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/v15091793", "pdfUrl": null, "abstract": "The HIV-1 latent reservoir is considered the major barrier to achieve the eradication, although some evidences indicate that curing HIV-1 is a feasible goal [...]", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1158/2159-8290.cd-nw2026-0078", "doi": "10.1158/2159-8290.cd-nw2026-0078", "title": "First CAR T-Cell Therapy Approved for Solid Tumors", "publicationYear": 2026, "publicationDate": "2026-07-21", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Discovery", "volume": null, "issue": null, "page": "OF1-OF1", "issn": "2159-8274, 2159-8290", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/2159-8290.cd-nw2026-0078", "pdfUrl": "https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-NW2026-0078/786956/First-CAR-T-Cell-Therapy-Approved-for-Solid", "abstract": "Abstract: China has approved the first CAR T-cell therapy that targets solid tumors, satricabtagene autoleucel (satri-cel), for patients with claudin 18.2–positive, HER2-negative gastric or gastro-esophageal junction cancer. The approval stems from a phase II trial that found the cells increased progression-free survival and overall survival. Scientists are excited about the decision but caution that more research is necessary to improve the effectiveness of CAR T cells against solid tumors.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.70675/2ff39929z2025z491czb6cbz30c7b9362e0f", "doi": "10.70675/2ff39929z2025z491czb6cbz30c7b9362e0f", "title": "Combined nanoparticle-mediated photothermal therapy to enhance CAR-T cell immunotherapy efficacy in stiff cholangiocarcinoma", "publicationYear": 2026, "publicationDate": "2026-04-08", "type": "dissertation", "publisher": "Agence Bibliographique de l'Enseignement Supérieur", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Sonia Becharef", "authorCount": 1, "firstAuthorAffiliation": "Université Paris Cité", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.70675/2ff39929z2025z491czb6cbz30c7b9362e0f", "pdfUrl": null, "abstract": "Thérapie photothermique médiée par des nanoparticules pour améliorer l'efficacité de l'immunothérapie CAR-T dans le cholangiocarcinome rigide Le cholangiocarcinome (CCA) est un cancer des voies biliaires présentant une forte résistance aux traitements conventionnels. Cette résistance est principalement attribuée aux fibroblastes associés au cancer (CAF) qui produisent une matrice extracellulaire (MEC) dense et rigide, constituant une barrière physique limitant l'accès des thérapies et des cellules immunitaires aux cellules tumorales. Pour surmonter cet obstacle, nous avons proposé l'utilisation d'une thérapie photothermique (PTT) médiée par des nanoparticules (NPs) métalliques pour moduler le microenvironnement tumoral (TME), déstabiliser la MEC et faciliter l'infiltration des cellules immunitaires. Les macrophages étant des régulateurs clés du TME, nous avons étudié les effets combinés de différentes NPs, avec ou sans activation laser, sur leur polarisation et l'inflammation. Nous avons développé un test prédictif rapide, basé sur une analyse en composantes principales (ACP), pour classifier les réponses immunitaires. En utilisant la lignée THP-1 DUAL différenciée en macrophages M0, M1 et M2, nous avons analysé des marqueurs inflammatoires clés et observé les changements d'expression génique induits par ces traitements. L'ACP nous a permis d'identifier des réponses distinctes des macrophages aux différents traitements avec des NPs métalliques. Les GIONF induisent initialement une polarisation des macrophages vers un profil M2, mais après exposition au laser, ces macrophages adoptent un phénotype de type M1. De plus, la PTT médiée par les GIONF favorise un sous-type de macrophages M1 distinct des macrophages M1 classiques, car ils n'activent pas la voie du facteur régulateur de l'interféron (IRF) mais induisent plutôt l'expression du gène de la synthase inductible de l'oxyde nitrique (iNOS). Ces résultats révèlent l'interaction complexe de la PTT médiée par les NPs sur le comportement des macrophages. La deuxième partie de cette thèse se concentre sur le développement d'un modèle de sphéroïde multicellulaire de CCA in vitro visant à reproduire le plus fidèlement possible le microenvironnement du CCA et ses barrières physiques. Ce modèle a ensuite été utilisé pour évaluer l'efficacité de l'immunothérapie par cellules T à récepteur antigénique chimérique (CAR-T) sur des sphéroïdes de CCA traités par la PTT médiée par des NPs. Afin de mimer les CAF, nous avons utilisé des cellules stellaires hépatiques immortalisées (hTERT-HSC), capables de sécréter du collagène de type 1 et pour le CCA, nous avons utilisé la lignée cellulaire humaine EGI-1. Cette étude a démontré une interaction protectrice synergique entre ces deux lignées cellulaires perturbée par l'exposition aux NPs et au laser, entraînant une augmentation de la mort cellulaire tumorale. Après validation du modèle sphéroïde multicellulaire 3D de CCA humain, nous avons introduit des cellules T non transduites et des cellules CAR-T ciblant les récepteurs EGFR. En cinq jours, les cellules CAR-T EGFR ont induit une destruction notable des sphéroïdes tumoraux, particulièrement dans les sphéroïdes EGI-1, par rapport aux sphéroïdes hTERT-HSC ou cocultivées. De plus, la combinaison des NPs GIONF, du laser et des cellules CAR-T EGFR a entraîné la destruction tumorale la plus significative. Ces résultats ont soutenu l'intérêt de mener des investigations précliniques in vivo. Pour valider les prédictions des études in vitro, nous sommes passés à un modèle in vivo. La dernière partie de ma thèse présente des résultats préliminaires sur les effets des NPs GIONF, suivis d'une hyperthermie modérée induite par la PTT et de la thérapie par cellules CAR-T EGFR, sur un modèle murin de CCA. Ce traitement combiné a provoqué une désorganisation notable des structures de collagène et a favorisé l'infiltration des cellules CAR-T, ralentissant efficacement la croissance tumorale.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.38124/ijisrt/25jun1371", "doi": "10.38124/ijisrt/25jun1371", "title": "Targeting Cancer at its Core: Cellular and Genetic Approaches Via CAR-T Cell Therapy CAR-T Cell Therapy of Cancer", "publicationYear": 2025, "publicationDate": "2025-09-04", "type": "journal-article", "publisher": "International Journal of Innovative Science and Research Technology", "containerTitle": "International Journal of Innovative Science and Research Technology", "volume": null, "issue": null, "page": "3325-3337", "issn": null, "isbn": null, "authors": "Bandaru Aashritha, Ambati Akshara, Nandini Kongara, P. Veeresh Babu", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.38124/ijisrt/25jun1371", "pdfUrl": "https://www.ijisrt.com/assets/upload/files/IJISRT25JUN1371.pdf", "abstract": "Cancer has recently overtaken other conditions as the foremost cause of death worldwide. While numerous conventional treatment modalities and cytotoxic immunotherapies are available, the intricate nature of tumor biology— driven by a multitude of genetic and cellular factors underlying tumorigenesis and metastasis—necessitates the development of advanced treatment approaches capable of acting on cellular as well as genetic fronts. Amid these advancements, Chimeric Antigen Receptor (CAR) T-cell therapy has risen as a pioneering frontier in the domain of T-cell engineering. Here, T cells obtained from the patient are engineered ex vivo to carry synthetic receptors designed to recognize tumor-associated antigens. A key feature is that these modified receptors can identify tumor antigens without requiring MHC presentation. Recently, CAR-T cell therapy has achieved significant clinical milestones, inducing remission in up to 80% of patients with hematologic malignancies, particularly those with acute lymphoblastic leukemia (ALL) and certain subtypes of non-Hodgkin lymphoma, such as large B-cell lymphoma. The anti-CD19 CAR design, UCART19, has demonstrated remarkable therapeutic potency in managing relapsed or refractory hematologic malignancies. Furthermore, other surface antigens, including CD20 and CD22, prevalent in various leukemias and lymphomas, are being actively explored as therapeutic targets, with multiple clinical trials underway. Although its application is presently concentrated on blood cancers, the integration of advanced modalities—such as bispecific CARs, tandem CARs, inhibitory CARs, multi-antigen targeting, CRISPR-based gene editing, and nanoparticle-mediated delivery—holds the promise of significantly enhancing its efficacy. These advancements may extend its utility to both hematologic and solid tumors, offering a treatment paradigm that is not only rapid and precise but also safer compared to traditional modalities. The purpose of this review is to offer an in-depth analysis of the benefits and emerging developments in CAR T-cell immunotherapy, while underscoring its rising advantage over conventional treatments like chemotherapy and radiotherapy.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1158/2643-3230.bcd-23-0272", "doi": "10.1158/2643-3230.bcd-23-0272", "title": "The Fate(s) of CAR T-Cell Therapy: Navigating the Risks of CAR+ T-Cell Malignancy", "publicationYear": 2024, "publicationDate": "2024-07-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Blood Cancer Discovery", "volume": "5", "issue": "4", "page": "249-257", "issn": "2643-3230, 2643-3249", "isbn": null, "authors": "Mohamed Abou-el-Enein", "authorCount": 1, "firstAuthorAffiliation": "Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California. 1", "isReferencedByCount": 36, "referenceCount": 78, "isOpenAccess": true, "licenseUrl": null, "funderNames": "National Cancer Institute", "funderIds": "10.13039/100000054", "url": "https://doi.org/10.1158/2643-3230.bcd-23-0272", "pdfUrl": "https://aacrjournals.org/bloodcancerdiscov/article-pdf/doi/10.1158/2643-3230.BCD-23-0272/3451523/bcd-23-0272.pdf", "abstract": "Abstract The introduction of chimeric antigen receptor (CAR) T-cell therapy represents a landmark advancement in treating resistant forms of cancer such as leukemia, lymphoma, and myeloma. However, concerns about long-term safety have emerged following an FDA investigation into reports of second primary malignancies (SPM) after CAR-T cell treatment. This review offers a thorough examination of how genetically modified T cells might transform into CAR+ SPM. It explores genetic and molecular pathways leading to T-cell lymphomagenesis, the balance between CAR T-cell persistence, stemness, and oncogenic risk, and the trade-off of T-cell exhaustion, which may limit therapy efficacy but potentially reduce lymphomagenesis risk. Significance: An FDA probe into 22 cases of second primary T-cell malignancies following CAR T-cell therapy stresses the need to investigate their origins. Few may arise from preexisting genetic and epigenetic alterations and those introduced during therapeutic engineering. Technological advances, regulatory oversight, and patient monitoring are essential to mitigate potential risks.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.20944/preprints202508.1325.v1", "doi": "10.20944/preprints202508.1325.v1", "title": "Immune Checkpoint Inhibitors and Car-T Cell Therapy: Thrombotic and Vascular Complications", "publicationYear": 2025, "publicationDate": "2025-08-19", "type": "posted-content", "publisher": "MDPI AG", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Miklos Udvardy", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.20944/preprints202508.1325.v1", "pdfUrl": null, "abstract": "Background: Due to the different genetic properties of malignant neoplasms and their tendency to cause the formation of blood clots, the risk of these complications is much higher than in the general population. There is even a higher risk of blood clots forming during chemotherapy or hormone therapy for cancer. Aim: This paper will summarise publications to gain a better understanding of the risks of blood clots associated with checkpoint inhibitors and CAR-T cell therapy of cancer. The review will also address potential problems and guide how to address them. Even when used on their own, checkpoint inhibitors can cause blood clots, albeit at a lower rate than chemotherapy; however, this assumption has not been definitively proven, as ICI-type agents are rarely given to cancer patients as monotherapy (or if given, these cancers baseline thrombogenicity is less active sui generis). The incidence of these problems varies depending on the type of disease, patient characteristics and somewhat on immunotherapeutic drug selection itself. It is important to inform doctors who prescribe these treatments of this fact and try to provide ideas which may help make good individual decisions. The anticoagulant prophylaxis is probably indicated in many such cases, even with monotherapy in cancer. However, still on a somewhat individual basis, as prospective, multicentre, double blind trials are not available, recommendations are based on some rather anecdotal, or retrospective data in respect of disease type, treatment and patient characteristics and the selection of an optimal anticoagulant prophylactic approach.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1182/blood-2020-140642", "doi": "10.1182/blood-2020-140642", "title": "A Protease-Mediated Regulatory Chimeric Antigen Receptor (CAR): \"Double Arm\" CAR System Improves Tumor-Cell-Specificity of CAR-T Cell Therapy", "publicationYear": 2020, "publicationDate": "2020-11-05", "type": "journal-article", "publisher": "American Society of Hematology", "containerTitle": "Blood", "volume": "136", "issue": "Supplement 1", "page": "41-41", "issn": "0006-4971, 1528-0020", "isbn": null, "authors": "Satoru Aoyama, Shunichiro Yasuda, Daisuke Watanabe, Hiroki Akiyama, Yoshihiro Umezawa, Ayako Nogami, Osamu Miura, Norihiko Kawamata", "authorCount": 8, "firstAuthorAffiliation": "Department of Immunotherapy for Hematopoietic Disorders, Tokyo Medical and Dental University (TMDU), Tokyo, Japan", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1182/blood-2020-140642", "pdfUrl": "https://ashpublications.org/blood/article/136/Supplement%201/41/471951/A-Protease-Mediated-Regulatory-Chimeric-Antigen", "abstract": "【 Introduction 】 CAR-T cell therapy has shown excellent therapeutic effects against some malignancies including refractory B cell lymphoma or leukemia. This adoptive T cell transfer therapy is an attractive methodology; however, there are several disadvantages to be overcome. Current CAR-T cell therapy targets single cell-surface molecule, which leads to damage of normal cells expressing the target protein. Such \"On-target / off-tumor\" effect is one of the major adverse effects. Improvement of target-cell-specificity is needed to avoid this serious adverse effect and to expand target diseases of this therapy. Here, we show the protease-mediated \"Double-Arm\" CAR-T cell system, which improved the specificity of CAR-T cell therapy by recognizing two distinct cell-surface proteins. We designed two types of CARs: \"Effector CAR\" and \"Scissors CAR\". The \"Effector CAR\" is constituted of a single chain Fv fragment (scFv) targeting a cell-surface protein (protein X) on tumor cells, Human Immunodeficiency Virus protease (HIVPR) recognition polypeptide sequence, and a functional domain of CD3-zeta. The \"scissors CAR\" is constituted of a recognition portion targeting another protein (protein Y) and HIVPR. The HIVPR induces cleavage of the recognition polypeptide sequence in the effector CAR leading to inactivation of the effector CAR when the CAR-T cells contact with cells expressing both proteins X and Y. 【 Material and Methods 】 For proof of principle, we first constructed \"anti-CD19 mCherry CAR\" harboring mCherry fluorescence protein in the cytoplasmic region under the HIVPR recognition polypeptide sequence. Also, we constructed \"anti-CD19 scissors CAR\", low affinity \"anti-HER2 (4D5-3) scissors CAR\" and high affinity \"anti-HER2 (4D5-8) scissors CAR\". To analyze the target-cell-dependent cleavage of mCherry CAR, 293T cells expressing these CARs were co-cultured with target cells, including K562 (CD19-, HER2-), Raji (CD19+, HER2+), or SK-BR-3 (CD19-, HER2+). To obtain target cells expressing both CD19 and HER2, Raji and SK-BR-3 cells were molecularly manipulated. (1) To evaluate efficiency of this system, after co-cultivation of CAR-transduced 293T and the target cells (K562, Raji, SK-BR-3), the localization of mCherry was examined under the microscopy and Western blotting. (2) To assess the T cell activation, we constructed \"anti-CD19 effector CAR\" and established Jurkat cells expressing both the \"effector CAR\" and the \"anti-HER2 scissors CAR\". These cells were co-cultured with wild type or engineered Raji or SK-BR-3 cells. T cell activation was analyzed with flowcytometric analysis. (3) To assess the CAR activity of this system, we transduced these CARs to primary T cells from healthy donors. After co-cultivation with the target cells, we measured target-specific cytotoxic activity. 【 Results 】 (1) Transduced \"anti-CD19 mCherry CAR\" was detected as a membrane-bound protein in 293T cells. Co-cultivation of 293T cells expressing both the \"anti-CD19 mCherry CAR\" and \"anti-HER2 scissors CAR\" with engineered Raji cells expressing both CD19 and HER2 induced cleavage of the recognition site and translocation of the mCherry from the membrane to the cytoplasm. These results suggested that this system would regulate activities of CAR-T cell through HIVPR-mediated cleavage of the \"effector CAR\" in vitro. (2) Jurkat cells expressing \"anti-CD19 effector CAR\" were activated through a target-cell-dependent manner. Furthermore, \"anti-HER2 scissors CAR\" attenuated T cell activation driven by \"anti-CD19 effector CAR\" when Jurkat cells expressing both the \"anti-CD19 effector CAR\" and the \"anti-HER2 scissors CAR\" contacted with target-cells expressing both CD19 and HER2. In addition, high affinity 4D5-8 scissors CAR showed more potent attenuation than the low affinity 4D5-3 scissors CAR. (3) Primary human T cells expressing \"anti-CD19 effector CAR\" showed CD19-expressing target-cell-specific cytotoxic activity. We also demonstrated that \"Double Arm\" primary human CAR-T cells showed tumor-cell-specificity as seen in cell-line models described above. 【Discussion】 Our \"Double-Arm\" CAR-T cell system has improved tumor-cell-specificity even in primary human T-cells as we expected. This system would attenuate the adverse effects of clinical CAR-T cell therapies. Disclosures No relevant conflicts of interest to declare.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.18609/cgti.2026.011", "doi": "10.18609/cgti.2026.011", "title": "In vivo CAR therapy: quo vadis?", "publicationYear": 2026, "publicationDate": "2026-02-04", "type": "journal-article", "publisher": "BioInsights Publishing, Ltd.", "containerTitle": "Cell and Gene Therapy Insights", "volume": "12", "issue": "1", "page": "87–92", "issn": "2059-7800", "isbn": null, "authors": "Adrian Bot, Xianghong Li", "authorCount": 2, "firstAuthorAffiliation": "Executive advisor, NewCo, Beverly Hills, CA, USA", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.18609/cgti.2026.011", "pdfUrl": null, "abstract": "In vivo CAR therapies are rapidly emerging as a strategy to address the scalability, access, and toxicity limitations associated with conventional ex vivo CAR-T cell products. This article reviews viral and LNP–RNA platform technologies, emerging clinical evidence, and key safety and regulatory considerations relative to established CAR-T and immune cell engager approaches. While early progress is encouraging, careful translational evaluation is essential to determine whether in vivo CAR strategies can ultimately meet or surpass current standards of care across oncology, autoimmunity, and other indications.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1182/blood-2019-121973", "doi": "10.1182/blood-2019-121973", "title": "A Novel Protease-Mediated Chimeric Antigen Receptor (CAR): \"Double-Arm\" CAR-T Cell System Improves Target Specificity of CAR-T Cell Therapy", "publicationYear": 2019, "publicationDate": "2019-11-13", "type": "journal-article", "publisher": "American Society of Hematology", "containerTitle": "Blood", "volume": "134", "issue": "Supplement_1", "page": "1941-1941", "issn": "0006-4971, 1528-0020", "isbn": null, "authors": "Satoru Aoyama, Shunichiro Yasuda, Daisuke Watanabe, Hiroki Akiyama, Yoshihiro Umezawa, Ayako Nogami, Osamu Miura, Norihiko Kawamata", "authorCount": 8, "firstAuthorAffiliation": "Department of Immunotherapy for Hematopoietic Disorders, Tokyo Medical and Dental University (TMDU), Tokyo, Japan", "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1182/blood-2019-121973", "pdfUrl": "https://ashpublications.org/blood/article/134/Supplement_1/1941/427865/A-Novel-ProteaseMediated-Chimeric-Antigen-Receptor", "abstract": "【 Introduction 】 CAR-T cell therapy is an attractive methodology in the field of cancer immunotherapy. Anti-CD19 CAR is used for treating refractory B cell malignancies and shows excellent therapeutic effects. However, there are several disadvantages to be overcome in this therapy. \"On-target / off-tumor\" effect is one of such adverse effects. Current CAR-T cell therapy targets single cell-surface molecule, which leads to damage of normal cells expressing the target protein. Improvement of target-cell-specificity is one of important issues in CAR-T cell therapy to avoid this serious adverse effect. Here, we show the protease-mediated \"Double-Arm\" CAR-T cell system (Figure), which improved the specificity of CAR-T cell therapy by recognizing two distinct cell-surface proteins. We designed two types of CAR: \"Effector CAR\" and \"Scissors CAR\" (Figure, left panel). The \"effector CAR\" is constituted of a single chain Fv fragment (scFv) targeting a cell-surface protein (protein X) on tumor cells, Human Immunodeficiency Virus protease (HIVPR) recognition polypeptide sequence, and a functional domain of CD3-zeta. The \"scissors CAR\" is constituted of a recognition portion targeting another protein (protein Y) and HIVPR. The HIVPR induces cleavage of the recognition polypeptide sequence in the effector CAR leading to inactivation of the effector CAR when the CAR-T cells contact with cells expressing both protein X and Y (Figure, right panel). 【 Material and Methods 】 For proof of principle, we first constructed \"anti-CD19 mCherry CAR\" harboring mCherry fluorescence protein in the cytoplasmic region under the HIVPR recognition polypeptide sequence. Also, we constructed \"anti-CD19 scissors CAR\" and \"anti-HER2 scissors CAR\". To analyze the target-cell-dependent cleavage of mCherry CAR, 293T cells expressing these CARs were co-cultured with target cells, including K562 (CD19-, HER2-), Raji (CD19+, HER2+), or SK-BR-3 (CD19-, HER2+). To obtain target cells expressing both CD19 and HER2, Raji and SK-BR-3 cells were molecularly manipulated. (1) To evaluate efficiency of this system, after co-cultivation of CAR-transduced 293T cell and target cells (K562, Raji, SK-BR-3), the localization of mCherry was examined under the microscopy and Western blotting. (2) To assess the T cell activation, we constructed \"anti-CD19 effector CAR\" and established Jurkat cells expressing both the \"effector CAR\" and the \"anti-HER2 scissors CAR\". These cells were co-cultured with wild type or engineered Raji or SK-BR-3 cells. T cell activation was analyzed with flowcytometric analysis and IL-2 mRNA expression measured with qRT-PCR. 【 Results 】 (1) Transduced \"anti-CD19 mCherry CAR\" was detected as a membrane-bound protein in 293T cell. Co-cultivation of 293T cell expressing both the \"anti-CD19 mCherry CAR\" and \"anti-HER2 scissors CAR\" with engineered Raji cells expressing both CD19 and HER2 induced cleavage of the recognition site and translocation of the mCherry from the membrane to cytoplasm. In addition, the cleavage was inhibited by a HIVPR inhibitor, Saquinavir. These results suggested that this novel system would regulate CAR-T cell activities through HIVPR-mediated cleavage of the \"effector CAR\" in vitro. (2) Jurkat cells expressing \"anti-CD19 effector CAR\" were activated through the target-cell-dependent manner. In addition, \"anti-HER2 scissors CAR\" attenuated T cell activation driven by \"anti-CD19 effector CAR\" when Jurkat cells expressing both the \"anti-CD19 effector CAR\" and the \"anti-HER2 scissors CAR\" contacted with the target cells expressing both CD19 and HER2. 【Discussion】 This is a novel protease-mediated controllable CAR system. The \"scissors CAR\" regulated activity of CAR-T cells depending on expression pattern of target molecules on the target cells. Our \"Double-Arm\" CAR-T cell system (Figure) would improve target specificity. It would attenuate the adverse effects and contribute to expansion in application of CAR-T cell therapy other than B cell malignancies. Figure Disclosures No relevant conflicts of interest to declare.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.51731/cjht.2024.884", "doi": "10.51731/cjht.2024.884", "title": "Anticytokine Therapy and Corticosteroids for Cytokine Release Syndrome and for Neurotoxicity Following T-Cell Engager or CAR T-Cell Therapy", "publicationYear": 2024, "publicationDate": "2024-05-02", "type": "journal-article", "publisher": "Canadian Journal of Health Technologies, CADTH", "containerTitle": "Canadian Journal of Health Technologies", "volume": "4", "issue": "5", "page": null, "issn": "2563-6596", "isbn": null, "authors": "CADTH", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.51731/cjht.2024.884", "pdfUrl": "http://canjhealthtechnol.ca/index.php/cjht/article/download/RC1534/RC1534", "abstract": "What Is the Issue? Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are the most common toxicities secondary to T-cell engager or chimeric antigen receptor (CAR) T-cell therapy. The US FDA and Health Canada approved tocilizumab, an anti-interleukin-6 receptor antagonist, for the management of severe or life-threatening cases of CRS. Corticosteroids also play an important role in CRS management and are the mainstay of ICANS management. Decision-makers are interested in understanding the use of anticytokine drugs (i.e., tocilizumab, anakinra, siltuximab) and/or corticosteroids in the management of CRS and ICANS following T-cell engager or CAR T-cell therapy. What Did We Do? We identified and summarized the literature comparing the clinical effectiveness and safety of anticytokine therapy and/or corticosteroids with alternative care or treatment as usual for treating and preventing of CRS and ICANS. We also searched for evidence-based recommendations for the use of anticytokine therapy and/or corticosteroids to treat and prevent CRS and ICANS. A research information specialist conducted a literature search of peer-reviewed and grey literature sources published between January 1, 2019 and February 26, 2024 for CRS; and between January 1, 2019 and March 4, 2024 for ICANS. One reviewer screened citations for inclusion based on predefined criteria, critically appraised the included studies, and narratively summarized the findings. What Did We Find? This report presents evidence-based findings on 3 retrospective chart review studies, 2 prospective cohort studies, and 4 consensus guidelines. Limited and low-quality clinical evidence from studies with a high risk of bias suggested that early use of tocilizumab or corticosteroids, or prophylactic use of tocilizumab or anakinra may reduce the risk of a high-grade CRS without a negative impact on neurotoxicity or immunotherapy treatment outcomes. The included guidelines recommend the use of tocilizumab for treatment of higher-grade CRS, or for treatment of grade 1 CRS if symptoms persist for 3 days or more. Corticosteroids could be added in conjunction if there is no improvement or persistent symptoms after tocilizumab therapy. For the management of ICANS in the absence of concurrent CRS, supportive care is the preferred treatment option for grade 1 ICANS, while corticosteroids are recommended for the management of grade 2 to 4 ICANS. In the presence of concurrent CRS, guidelines recommend tocilizumab therapy as per management of CRS, and corticosteroids should be continued until improvement to grade 1. We did not identify any clinical evidence regarding the clinical efficacy and safety of anticytokine therapy and/or corticosteroids for treatment of CRS and ICANS compared with alternative treatment or treatment as usual. We also did not identify any guidelines for the use of prophylactic anticytokine therapy, corticosteroids, or both for the prevention of CRS and ICANS. What Does This Mean? Despite limited and low-quality evidence, the findings suggest some potential benefits of prophylactic or early use of anticytokine therapy and corticosteroids for the management of immunotherapy-related toxicities. Guidelines offer guidance on the management of CRS, ICANS and other less common toxicities related to immunotherapy based on the available low-quality evidence. When using the clinical evidence and recommendations summarized in this report to inform decisions, decision-makers should consider that the evidence is limited and of low quality. To improve the certainty of findings, there is a need for more robust prospective clinical trials with larger sample sizes, and lower risk of bias.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1182/blood-2025-5484", "doi": "10.1182/blood-2025-5484", "title": "Transplantation in combination with CAR T-cell therapy for refractory/relapsed aggressive B-cell lymphoma after failure of CD19 CAR-T cell therapy", "publicationYear": 2025, "publicationDate": "2025-11-03", "type": "journal-article", "publisher": "American Society of Hematology", "containerTitle": "Blood", "volume": "146", "issue": "Supplement 1", "page": "5484-5484", "issn": "0006-4971, 1528-0020", "isbn": null, "authors": "Fan Yang, Rui Liu, Yuelu Guo, Lixia Ma, Miaomiao Cao, Biping Deng, Haifeng Wu, Alex H. Zhang, Xiaoyan Ke, Kai Hu", "authorCount": 10, "firstAuthorAffiliation": "1Department of Lymphoma and Myeloma Research Center, Beijing, China", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1182/blood-2025-5484", "pdfUrl": "https://ashpublications.org/blood/article-pdf/146/Supplement%201/5484/2460962/blood-8231-main.pdf", "abstract": "Abstract Background: The prognosis for patients with refractory/relapsed aggressive B-cell lymphoma (R/R B-NHL) who have failed CD19 CAR-T cell therapy is exceptionally poor. Aims: This study conducted a retrospective analysis of the treatment efficacy and survival of the patients who underwent autologous transplantation combined with another targeted CAR-T therapy(auto-HSCT+CAR-T) and allogeneic transplantation with donor-derived CAR-T therapy (allo-HSCT+donor CAR-T) after failing CD19 CAR-T therapy. Methods: From May 2020 to March 2024, 24 patients were included (Table 1). The median age was 39 years (range: 16-54). Diagnoses included DLBCL NOS (n=12), HGBL (n=9), PMBL (n=2), and MCL (n=1). The median IPI score was 3 (range: 2-5). Fourteen patients (58.3%) presented with extranodal lesions, and 8 (33.3%) had bulky disease (&amp;gt;7cm).After bridging therapy (BT), 7 of the 24 patients (29.2%) exhibited disease progression before transplantation. Twelve patients (50%) were selected for auto-HSCT+CAR-T and the other 12 (50%) for allo-HSCT+donor CAR-T, at a median of 8 months (range: 2-48) post-CD19 CAR-T infusion. Prior to the study, CD20/CD22 antigen expression in tumor tissue was confirmed by pathology, with the target selected based on antigen expression. The conditioning regimen for the auto-HSCT+CAR-T group was BEAM, while that for the allo-HSCT+donor CAR-T group consisted of a busulfan-fludarabine-based regimen. In the allo-HSCT+donor CAR-T group, there was 1 MSD, 1 MUD, and 10 HID. Tacrolimus,MMF, short-term MTX, and ATG were employed for GVHD prophylaxis. Results: The median number of CAR-T cells infused was 2.2×10^6/kg (range: 0.3-4.48×10^6/kg). The expansion of CAR-T cells was monitored in all patients, with the median time for both auto and donor CAR-T cells being 7 days post-infusion. The incidence of grade 3 CRS was 25% (6/24). Grade 1-2 neurotoxicity occurred in 4.2% (1/24) of patients. Nineteen patients experienced infections, with 16 (66.7%) suffering from grade 3 or higher severity. Among the patients who underwent allo-HSCT+donor CAR-T, 3 of 12 (25%) developed aGVHD(Table 2). The median follow-up period was 28.6 months (95% CI: 25.2-52.2). The ORR was 91.7%, with a CR of 83.3% and a PR of 8.3%. The median OS was 14.56 months (95% CI: 8.9-45.6), and the median PFS was 9.21 months (95% CI: 5.12-12.9). Among the 12 patients treated with autoHSCT+CAR-T therapy, 11 (91.7%) achieved CR, while 7 (63.6%) survived disease-free. In this cohort, 4 patients (33.3%) relapsed and died, while 1 patient (8.3%) died from an infection. In the alloHSCT+donor CAR-T group, 9 (75%) achieved CR and 2 (16.7%) achieved PR, with 4 (36.4%) surviving disease-free. In this group, 3 patients (25%) relapsed and died, while 5 (41.7%) died due to infections. Conclusion: Transplantation combined with CAR-T therapy presents an effective option for R/R B-cell lymphoma following the failure of CD19 CAR-T. Effective BT prior to transplantation significantly enhances survival rates.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.46765/2675-374x.2022v3n2p167", "doi": "10.46765/2675-374x.2022v3n2p167", "title": "Management of Infections and Vaccination in CAR-T Cell Therapy", "publicationYear": 2022, "publicationDate": "2022-11-23", "type": "journal-article", "publisher": "Journal of Bone Marrow Transplantation and Cellular Therapy", "containerTitle": "JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY", "volume": "3", "issue": "2", "page": "167", "issn": "2675-374X", "isbn": null, "authors": "Clarisse martins Machado", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.46765/2675-374x.2022v3n2p167", "pdfUrl": "https://jbmtct.sbtmo.org.br/jbmtct/article/download/167/118", "abstract": "Candidates for CAR-T cell therapy are at increased risk of infections due to the high degree of pre-existing immunosuppression. In addittion, the currently approved CAR-T cell therapy products have severe toxicities, including cytokine release syndrome (CRS) and immune-effector cell associated neurological syndrome (ICANS), which treatments may result in deep and long-term immunological deficits, as the CAR-T cells can persist for years. Approximately 18% to 34% of patients develop infections within the first 2 months after CAR-T therapy despite antimicrobial prophylaxis. The goals of the present manuscript are: 1) Describe the procedures necessary for the clinical and epidemiological evaluation of the chimeric antigen receptor T-cell therapy (CAR-T cell therapy) candidate, classify the infectious risk, define the criteria for the implementation of prophylactic, empirical and preemptive antimicrobial strategies and guide laboratory and clinical monitoring of the infectious events; 2) Define the indications and contraindications of inactivated and attenuated vaccines and propose a vaccination schedule before and after CAR-T therapy.", "subject": null, "language": null, "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1155/2023/8030440", "doi": "10.1155/2023/8030440", "title": "Vaccine Boosting CAR-T Cell Therapy: Current and Future Strategies", "publicationYear": 2023, "publicationDate": "2023-01-31", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advances in Cell and Gene Therapy", "volume": "2023", "issue": null, "page": "1-9", "issn": "2573-8461", "isbn": null, "authors": "Emmanuel Owusu Ansah, Andy Baah, Emmanuel Boateng Agyenim", "authorCount": 3, "firstAuthorAffiliation": "Department of Gene Therapy, Thrivus Institute for Biomedical Science and Technology, Accra, Ghana", "isReferencedByCount": 7, "referenceCount": 77, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1155/2023/8030440", "pdfUrl": "http://downloads.hindawi.com/journals/acgt/2023/8030440.pdf", "abstract": "Immunotherapy for cancer treatment is growing at an unprecedented rate since the inception of chimeric antigen receptor T (CAR-T) cells. However, the efficacy of CAR-T cells against solid tumors is hampered by various issues, including “on-target, off-tumor toxicities,” T cell exhaustion, and immunosuppressive tumor microenvironment. To overcome these limitations, recent advances focus on optimizing CAR-T cells using vaccines to develop more effective cell immunotherapies. Here, we summarize the most recent studies on how vaccine-based CAR-T therapies are advancing the response of cancer immunotherapy as well as the current state of their clinical and preclinical development. Finally, we share perspectives on how future studies can incorporate other strategies to augment the antitumor response of vaccine-assisted CAR-T cell therapy.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1158/2159-8290.cd-nd2018-008", "doi": "10.1158/2159-8290.cd-nd2018-008", "title": "CAR T-cell Therapy for Solid Tumors?", "publicationYear": 2018, "publicationDate": "2018-11-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Discovery", "volume": "8", "issue": "11", "page": "1341-1341", "issn": "2159-8274, 2159-8290", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/2159-8290.cd-nd2018-008", "pdfUrl": "https://aacrjournals.org/cancerdiscovery/article-pdf/8/11/1341/1809770/1341.pdf", "abstract": "Abstract Scientists have identified a wide variety of challenges preventing the development of effective CAR T-cell therapies for solid tumors, but they are investigating just as many potential solutions. Progress has been slow, but many researchers remain optimistic that successful CAR T-cell therapies, either alone or in combination with other treatments, will eventually be developed.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1097/jat.0000000000000183", "doi": "10.1097/jat.0000000000000183", "title": "The Role of Physical Therapy Following CAR T-Cell Therapy: A Case Report", "publicationYear": 2022, "publicationDate": "2022-07", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Journal of Acute Care Physical Therapy", "volume": "13", "issue": "3", "page": "152-158", "issn": "2158-8686", "isbn": null, "authors": "Helaine Firestein", "authorCount": 1, "firstAuthorAffiliation": "Helaine Firestein, PT, DPT, CLTMemorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065 (USA)..", "isReferencedByCount": 2, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1097/jat.0000000000000183", "pdfUrl": null, "abstract": "Background: Diffuse large B-cell lymphoma (DLBCL) affects 7 out of 100 000 people in the United States every year. Chimeric antigen receptor (CAR) T-cell therapy is approved by the Food and Drug Administration to treat patients with relapsed/refractory DLBCL who have not responded to 2 prior lines of therapy. CAR T-cell therapy can lead to debilitating side effects necessitating rehabilitation intervention. Case Description: This case report details a 38-year-old woman with refractory DLBCL who received CAR T-cell therapy. The patient experienced grade 2 cytokine release syndrome and grade 4 immune effector cell-associated neurotoxicity syndrome, which resulted in, among other symptoms, lower extremity paraplegia. Upon medical stabilization, the patient was referred to physical therapy. Outcomes: The patient participated in acute care rehabilitation for 8 weeks and progressed significantly toward her prior level of function before being discharged to an inpatient rehabilitation facility. Upon discharge, the patient was able to ambulate with a rolling walker, a knee orthosis, and supervision for safety and had initiated stair training. Discussion/Conclusion: Physical therapists need to understand and recognize the range of side effects that can occur following CAR T-cell therapy. As more patients receive CAR T-cell therapy to treat malignancies, acute care oncology units will undoubtedly be challenged with patients exhibiting severe side effects. Physical therapists are well trained to address physical impairments resulting from CAR T-cell therapy's side effects and will play a vital role in these patients' interdisciplinary care.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1158/2159-8290.cd-nb2017-155", "doi": "10.1158/2159-8290.cd-nb2017-155", "title": "FDA Approves Second CAR T-cell Therapy", "publicationYear": 2018, "publicationDate": "2018-01-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Discovery", "volume": "8", "issue": "1", "page": "5-6", "issn": "2159-8274, 2159-8290", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 93, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/2159-8290.cd-nb2017-155", "pdfUrl": "https://aacrjournals.org/cancerdiscovery/article-pdf/8/1/5/1838844/5.pdf", "abstract": "Abstract The FDA approved the chimeric antigen receptor T-cell therapy axicabtagene ciloleucel, making it the second such treatment for blood cancers in the United States. The therapy is indicated for adults with certain non-Hodgkin lymphomas who have tried at least two other treatments.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.3390/ijms21124303", "doi": "10.3390/ijms21124303", "title": "CAR-T Cell Therapy", "publicationYear": 2020, "publicationDate": "2020-06-17", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "International Journal of Molecular Sciences", "volume": "21", "issue": "12", "page": "4303", "issn": "1422-0067", "isbn": null, "authors": "Aamir Ahmad", "authorCount": 1, "firstAuthorAffiliation": "Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA", "isReferencedByCount": 36, "referenceCount": 18, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/ijms21124303", "pdfUrl": null, "abstract": "CAR-T therapy has revolutionized the treatment of select hematological malignancies, namely, acute lymphoblastic leukemia and large B-cell lymphomas [...]", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1158/2159-8290.cd-nb2017-058", "doi": "10.1158/2159-8290.cd-nb2017-058", "title": "CAR T-cell Therapy: Defining Response Characteristics", "publicationYear": 2017, "publicationDate": "2017-06-01", "type": "journal-article", "publisher": "American Association for Cancer Research (AACR)", "containerTitle": "Cancer Discovery", "volume": "7", "issue": "6", "page": "OF8-OF8", "issn": "2159-8274, 2159-8290", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1158/2159-8290.cd-nb2017-058", "pdfUrl": "https://aacrjournals.org/cancerdiscovery/article/7/6/OF8/6055/CAR-T-cell-Therapy-Defining-Response", "abstract": "Abstract Findings from a phase I study suggest that the durability of patients' response to CAR T-cell therapy, and their long-term survival, are influenced by whether they have minimal residual or morphologic disease prior to treatment. The former fared better overall, and also experienced less-severe side effects from this form of immunotherapy.", "subject": null, "language": "en", "_run_id": "eLEugrlIHYHM872dc", "_dataset_id": "kWUSK5DjJTPDAbvg0"}
{"paperId": "10.1016/j.cell.2006.07.024", "doi": "10.1016/j.cell.2006.07.024", "title": "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors", "publicationYear": 2006, "publicationDate": "2006-08", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell", "volume": "126", "issue": "4", "page": "663-676", "issn": "0092-8674", "isbn": null, "authors": "Kazutoshi Takahashi, Shinya Yamanaka", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 22551, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.cell.2006.07.024", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1021/ja809598r", "doi": "10.1021/ja809598r", "title": "Organometal Halide Perovskites as Visible-Light Sensitizers for Photovoltaic Cells", "publicationYear": 2009, "publicationDate": "2009-05-06", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "131", "issue": "17", "page": "6050-6051", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu Miyasaka", "authorCount": 4, "firstAuthorAffiliation": "Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan, Graduate School of Engineering, Toin University of Yokohama, and Peccell Technologies, Inc., 1614 Kurogane-cho, Aoba, Yokohama, Kanagawa 225-8502, Japan, and Graduate School of Engineering, Tokyo Polytechnic University, 1583 Iiyama, Atsugi, Kanagawa 243-0297, Japan", "isReferencedByCount": 22154, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/ja809598r", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1128/mr.59.1.143-169.1995", "doi": "10.1128/mr.59.1.143-169.1995", "title": "Phylogenetic identification and in situ detection of individual microbial cells without cultivation", "publicationYear": 1995, "publicationDate": "1995-03", "type": "journal-article", "publisher": "American Society for Microbiology", "containerTitle": "Microbiological Reviews", "volume": "59", "issue": "1", "page": "143-169", "issn": "0146-0749", "isbn": null, "authors": "R I Amann, W Ludwig, K H Schleifer", "authorCount": 3, "firstAuthorAffiliation": "Lehrstuhl für Mikrobiologie, Technische Universität München, Germany.", "isReferencedByCount": 19744, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://journals.asm.org/non-commercial-tdm-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1128/mr.59.1.143-169.1995", "pdfUrl": "https://journals.asm.org/doi/pdf/10.1128/mr.59.1.143-169.1995", "abstract": "The frequent discrepancy between direct microscopic counts and numbers of culturable bacteria from environmental samples is just one of several indications that we currently know only a minor part of the diversity of microorganisms in nature. A combination of direct retrieval of rRNA sequences and whole-cell oligonucleotide probing can be used to detect specific rRNA sequences of uncultured bacteria in natural samples and to microscopically identify individual cells. Studies have been performed with microbial assemblages of various complexities ranging from simple two-component bacterial endosymbiotic associations to multispecies enrichments containing magnetotactic bacteria to highly complex marine and soil communities. Phylogenetic analysis of the retrieved rRNA sequence of an uncultured microorganism reveals its closest culturable relatives and may, together with information on the physicochemical conditions of its natural habitat, facilitate more directed cultivation attempts. For the analysis of complex communities such as multispecies biofilms and activated-sludge flocs, a different approach has proven advantageous. Sets of probes specific to different taxonomic levels are applied consecutively beginning with the more general and ending with the more specific (a hierarchical top-to-bottom approach), thereby generating increasingly precise information on the structure of the community. Not only do rRNA-targeted whole-cell hybridizations yield data on cell morphology, specific cell counts, and in situ distributions of defined phylogenetic groups, but also the strength of the hybridization signal reflects the cellular rRNA content of individual cells. From the signal strength conferred by a specific probe, in situ growth rates and activities of individual cells might be estimated for known species. In many ecosystems, low cellular rRNA content and/or limited cell permeability, combined with background fluorescence, hinders in situ identification of autochthonous populations. Approaches to circumvent these problems are discussed in detail.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1016/j.cell.2007.11.019", "doi": "10.1016/j.cell.2007.11.019", "title": "Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors", "publicationYear": 2007, "publicationDate": "2007-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell", "volume": "131", "issue": "5", "page": "861-872", "issn": "0092-8674", "isbn": null, "authors": "Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 17431, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.cell.2007.11.019", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1126/science.284.5411.143", "doi": "10.1126/science.284.5411.143", "title": "Multilineage Potential of Adult Human Mesenchymal Stem Cells", "publicationYear": 1999, "publicationDate": "1999-04-02", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "284", "issue": "5411", "page": "143-147", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "Mark F. Pittenger, Alastair M. Mackay, Stephen C. Beck, Rama K. Jaiswal, Robin Douglas, Joseph D. Mosca, Mark A. Moorman, Donald W. Simonetti, Stewart Craig, Daniel R. Marshak", "authorCount": 10, "firstAuthorAffiliation": "Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231–3043, USA.", "isReferencedByCount": 15864, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.284.5411.143", "pdfUrl": null, "abstract": "Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1093/nar/16.3.1215", "doi": "10.1093/nar/16.3.1215", "title": "A simple salting out procedure for extracting DNA from human nucleated cells", "publicationYear": 1988, "publicationDate": "1988", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Nucleic Acids Research", "volume": "16", "issue": "3", "page": "1215-1215", "issn": "0305-1048, 1362-4962", "isbn": null, "authors": "S.A. Miller, D.D. Dykes, H.F. Polesky", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 14913, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/nar/16.3.1215", "pdfUrl": "http://academic.oup.com/nar/article-pdf/16/3/1215/4063153/16-3-1215.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1080/14653240600855905", "doi": "10.1080/14653240600855905", "title": "Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement", "publicationYear": 2006, "publicationDate": "2006", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cytotherapy", "volume": "8", "issue": "4", "page": "315-317", "issn": "1465-3249", "isbn": null, "authors": "M. Dominici, K. Le Blanc, I. Mueller, I. Slaper-Cortenbach, F.C Marini, D.S. Krause, R.J. Deans, A. Keating, D.J. Prockop, E.M. Horwitz", "authorCount": 10, "firstAuthorAffiliation": null, "isReferencedByCount": 14610, "referenceCount": 8, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1080/14653240600855905", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/256495a0", "doi": "10.1038/256495a0", "title": "Continuous cultures of fused cells secreting antibody of predefined specificity", "publicationYear": 1975, "publicationDate": "1975-08", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "256", "issue": "5517", "page": "495-497", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "G. KÖHLER, C. MILSTEIN", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 13433, "referenceCount": 14, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/256495a0", "pdfUrl": "http://www.nature.com/articles/256495a0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/35104607", "doi": "10.1038/35104607", "title": "Photoelectrochemical cells", "publicationYear": 2001, "publicationDate": "2001-11", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "414", "issue": "6861", "page": "338-344", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Michael Grätzel", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 12254, "referenceCount": 49, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/35104607", "pdfUrl": "http://www.nature.com/articles/35104607.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1063/1.1736034", "doi": "10.1063/1.1736034", "title": "Detailed Balance Limit of Efficiency of<i>p-n</i>Junction Solar Cells", "publicationYear": 1961, "publicationDate": "1961-03-01", "type": "journal-article", "publisher": "AIP Publishing", "containerTitle": "Journal of Applied Physics", "volume": "32", "issue": "3", "page": "510-519", "issn": "0021-8979, 1089-7550", "isbn": null, "authors": "William Shockley, Hans J. Queisser", "authorCount": 2, "firstAuthorAffiliation": "Shockley Transistor, Unit of Clevite Transistor, Palo Alto, California", "isReferencedByCount": 12174, "referenceCount": 47, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1063/1.1736034", "pdfUrl": "https://pubs.aip.org/aip/jap/article-pdf/32/3/510/18323491/510_1_online.pdf", "abstract": "In order to find an upper theoretical limit for the efficiency of p-n junction solar energy converters, a limiting efficiency, called the detailed balance limit of efficiency, has been calculated for an ideal case in which the only recombination mechanism of hole-electron pairs is radiative as required by the principle of detailed balance. The efficiency is also calculated for the case in which radiative recombination is only a fixed fraction fc of the total recombination, the rest being nonradiative. Efficiencies at the matched loads have been calculated with band gap and fc as parameters, the sun and cell being assumed to be blackbodies with temperatures of 6000°K and 300°K, respectively. The maximum efficiency is found to be 30% for an energy gap of 1.1 ev and fc = 1. Actual junctions do not obey the predicted current-voltage relationship, and reasons for the difference and its relevance to efficiency are discussed.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1101/gr.186072.114", "doi": "10.1101/gr.186072.114", "title": "CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes", "publicationYear": 2015, "publicationDate": "2015-07", "type": "journal-article", "publisher": "Cold Spring Harbor Laboratory", "containerTitle": "Genome Research", "volume": "25", "issue": "7", "page": "1043-1055", "issn": "1088-9051, 1549-5469", "isbn": null, "authors": "Donovan H. Parks, Michael Imelfort, Connor T. Skennerton, Philip Hugenholtz, Gene W. Tyson", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 11983, "referenceCount": 47, "isOpenAccess": true, "licenseUrl": null, "funderNames": "Natural Sciences and Engineering Research Council of Canada, Great Barrier Reef Foundation, Australian Research Council, Discovery Outstanding Researcher Award, Australian Research Council, Australian Research Council", "funderIds": "10.13039/501100000038, 10.13039/100015344, 10.13039/501100000923, 10.13039/501100000923, 10.13039/501100000923", "url": "https://doi.org/10.1101/gr.186072.114", "pdfUrl": null, "abstract": "Large-scale recovery of genomes from isolates, single cells, and metagenomic data has been made possible by advances in computational methods and substantial reductions in sequencing costs. Although this increasing breadth of draft genomes is providing key information regarding the evolutionary and functional diversity of microbial life, it has become impractical to finish all available reference genomes. Making robust biological inferences from draft genomes requires accurate estimates of their completeness and contamination. Current methods for assessing genome quality are ad hoc and generally make use of a limited number of “marker” genes conserved across all bacterial or archaeal genomes. Here we introduce CheckM, an automated method for assessing the quality of a genome using a broader set of marker genes specific to the position of a genome within a reference genome tree and information about the collocation of these genes. We demonstrate the effectiveness of CheckM using synthetic data and a wide range of isolate-, single-cell-, and metagenome-derived genomes. CheckM is shown to provide accurate estimates of genome completeness and contamination and to outperform existing approaches. Using CheckM, we identify a diverse range of errors currently impacting publicly available isolate genomes and demonstrate that genomes obtained from single cells and metagenomic data vary substantially in quality. In order to facilitate the use of draft genomes, we propose an objective measure of genome quality that can be used to select genomes suitable for specific gene- and genome-centric analyses of microbial communities.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1126/science.123.3191.309", "doi": "10.1126/science.123.3191.309", "title": "On the Origin of Cancer Cells", "publicationYear": 1956, "publicationDate": "1956-02-24", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "123", "issue": "3191", "page": "309-314", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "Otto Warburg", "authorCount": 1, "firstAuthorAffiliation": "Director of the Max Planck Institute for Cell Physiology, Berlin-Dahlem, Germany", "isReferencedByCount": 11437, "referenceCount": 69, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.123.3191.309", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/ncb1596", "doi": "10.1038/ncb1596", "title": "Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells", "publicationYear": 2007, "publicationDate": "2007-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Cell Biology", "volume": "9", "issue": "6", "page": "654-659", "issn": "1465-7392, 1476-4679", "isbn": null, "authors": "Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 11182, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/ncb1596", "pdfUrl": "https://www.nature.com/articles/ncb1596.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/32588", "doi": "10.1038/32588", "title": "Dendritic cells and the control of immunity", "publicationYear": 1998, "publicationDate": "1998-03", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "392", "issue": "6673", "page": "245-252", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Jacques Banchereau, Ralph M. Steinman", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 10889, "referenceCount": 103, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/32588", "pdfUrl": "http://www.nature.com/articles/32588.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1126/science.1228604", "doi": "10.1126/science.1228604", "title": "Efficient Hybrid Solar Cells Based on Meso-Superstructured Organometal Halide Perovskites", "publicationYear": 2012, "publicationDate": "2012-11-02", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "338", "issue": "6107", "page": "643-647", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "Michael M. Lee, Joël Teuscher, Tsutomu Miyasaka, Takurou N. Murakami, Henry J. Snaith", "authorCount": 5, "firstAuthorAffiliation": "Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK.", "isReferencedByCount": 10155, "referenceCount": 39, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.1228604", "pdfUrl": null, "abstract": "Perovskite Photovoltaics For many types of low-cost solar cells, including those using dye-sensitized titania, performance is limited by low open-circuit voltages. Lee et al. (p. 643 , published online 4 October; see the Perspective by Norris and Aydil ) have developed a solid-state cell in which structured films of titania or alumina nanoparticles are solution coated with a lead-halide perovskite layer that acts as the absorber and n-type photoactive layer. These particles are coated with a spirobifluorene organic-hole conductor in a solar cell with transparent oxide and metal contacts. For the alumina particles, power conversion efficiencies of up to 10.9% were obtained.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1126/science.1243982", "doi": "10.1126/science.1243982", "title": "Electron-Hole Diffusion Lengths Exceeding 1 Micrometer in an Organometal Trihalide Perovskite Absorber", "publicationYear": 2013, "publicationDate": "2013-10-18", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "342", "issue": "6156", "page": "341-344", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "Samuel D. Stranks, Giles E. Eperon, Giulia Grancini, Christopher Menelaou, Marcelo J. P. Alcocer, Tomas Leijtens, Laura M. Herz, Annamaria Petrozza, Henry J. Snaith", "authorCount": 9, "firstAuthorAffiliation": "University of Oxford, Clarendon Laboratory, Parks Road, Oxford OX1 3PU, UK.", "isReferencedByCount": 9958, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.1243982", "pdfUrl": null, "abstract": "Unrestricted Travel in Solar Cells In the past 2 years, organolead halide perovskites have emerged as a promising class of light-harvesting media in experimental solar cells, but the physical basis for their efficiency has been unclear (see the Perspective by Hodes ). Two studies now show, using a variety of time-resolved absorption and emission spectroscopic techniques, that these materials manifest relatively long diffusion paths for charge carriers energized by light absorption. Xing et al. (p. 344 ) independently assessed (negative) electron and (positive) hole diffusion lengths and found them well-matched to one another to the ~100-nanometer optical absorption depth. Stranks et al. (p. 341 ) uncovered a 10-fold greater diffusion length in a chloride-doped material, which correlates with the material's particularly efficient overall performance. Both studies highlight effective carrier diffusion as a fruitful parameter for further optimization.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1126/science.270.5243.1789", "doi": "10.1126/science.270.5243.1789", "title": "Polymer Photovoltaic Cells: Enhanced Efficiencies via a Network of Internal Donor-Acceptor Heterojunctions", "publicationYear": 1995, "publicationDate": "1995-12-15", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "270", "issue": "5243", "page": "1789-1791", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "G. Yu, J. Gao, J. C. Hummelen, F. Wudl, A. J. Heeger", "authorCount": 5, "firstAuthorAffiliation": "Institute for Polymers and Organic Solids, University of California at Santa Barbara, Santa Barbara, CA 93106-5090, USA.", "isReferencedByCount": 9687, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.270.5243.1789", "pdfUrl": null, "abstract": "The carrier collection efficiency (η c ) and energy conversion efficiency (η e ) of polymer photovoltaic cells were improved by blending of the semiconducting polymer with C 60 or its functionalized derivatives. Composite films of poly(2-methoxy-5-(2′-ethyl-hexyloxy)-1,4-phenylene vinylene) (MEH-PPV) and fullerenes exhibit η c of about 29 percent of electrons per photon and η e of about 2.9 percent, efficiencies that are better by more than two orders of magnitude than those that have been achieved with devices made with pure MEH-PPV. The efficient charge separation results from photoinduced electron transfer from the MEH-PPV (as donor) to C 60 (as acceptor); the high collection efficiency results from a bicontinuous network of internal donor-acceptor heterojunctions.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1021/cr1002326", "doi": "10.1021/cr1002326", "title": "Solar Water Splitting Cells", "publicationYear": 2010, "publicationDate": "2010-11-10", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Chemical Reviews", "volume": "110", "issue": "11", "page": "6446-6473", "issn": "0009-2665, 1520-6890", "isbn": null, "authors": "Michael G. Walter, Emily L. Warren, James R. McKone, Shannon W. Boettcher, Qixi Mi, Elizabeth A. Santori, Nathan S. Lewis", "authorCount": 7, "firstAuthorAffiliation": "Division of Chemistry and Chemical Engineering, 210 Noyes Laboratory, 127-72 California Institute of Technology, Pasadena, California 91125", "isReferencedByCount": 9083, "referenceCount": 285, "isOpenAccess": true, "licenseUrl": "http://pubs.acs.org/page/policy/authorchoice_termsofuse.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/cr1002326", "pdfUrl": "http://pubs.acs.org/doi/pdf/10.1021/cr1002326", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1016/0016-7037(89)90286-x", "doi": "10.1016/0016-7037(89)90286-x", "title": "Abundances of the elements: Meteoritic and solar", "publicationYear": 1989, "publicationDate": "1989-01", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Geochimica et Cosmochimica Acta", "volume": "53", "issue": "1", "page": "197-214", "issn": "0016-7037", "isbn": null, "authors": "Edward Anders, Nicolas Grevesse", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 8947, "referenceCount": 168, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/0016-7037(89)90286-x", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/288373a0", "doi": "10.1038/288373a0", "title": "The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine", "publicationYear": 1980, "publicationDate": "1980-11", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "288", "issue": "5789", "page": "373-376", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Robert F. Furchgott, John V. Zawadzki", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 8942, "referenceCount": 18, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/288373a0", "pdfUrl": "http://www.nature.com/articles/288373a0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1016/0014-4827(88)90265-0", "doi": "10.1016/0014-4827(88)90265-0", "title": "A simple technique for quantitation of low levels of DNA damage in individual cells", "publicationYear": 1988, "publicationDate": "1988-03", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Experimental Cell Research", "volume": "175", "issue": "1", "page": "184-191", "issn": "0014-4827", "isbn": null, "authors": "Narendra P. Singh, Michael T. McCoy, Raymond R. Tice, Edward L. Schneider", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 8748, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/0014-4827(88)90265-0", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1126/science.1151526", "doi": "10.1126/science.1151526", "title": "Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells", "publicationYear": 2007, "publicationDate": "2007-12-21", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "318", "issue": "5858", "page": "1917-1920", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "Junying Yu, Maxim A. Vodyanik, Kim Smuga-Otto, Jessica Antosiewicz-Bourget, Jennifer L. Frane, Shulan Tian, Jeff Nie, Gudrun A. Jonsdottir, Victor Ruotti, Ron Stewart, Igor I. Slukvin, James A. Thomson", "authorCount": 12, "firstAuthorAffiliation": "Genome Center of Wisconsin, Madison, WI 53706–1580, USA.", "isReferencedByCount": 8643, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.1151526", "pdfUrl": null, "abstract": "Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. We show that four factors ( OCT4, SOX2, NANOG , and LIN28 ) are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells. These induced pluripotent human stem cells have normal karyotypes, express telomerase activity, express cell surface markers and genes that characterize human ES cells, and maintain the developmental potential to differentiate into advanced derivatives of all three primary germ layers. Such induced pluripotent human cell lines should be useful in the production of new disease models and in drug development, as well as for applications in transplantation medicine, once technical limitations (for example, mutation through viral integration) are eliminated.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/332411a0", "doi": "10.1038/332411a0", "title": "A novel potent vasoconstrictor peptide produced by vascular endothelial cells", "publicationYear": 1988, "publicationDate": "1988-03", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "332", "issue": "6163", "page": "411-415", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura, Yoko Tomobe, Mieko Kobayashi, Youji Mitsui, Yoshio Yazaki, Katsutoshi Goto, Tomoh Masaki", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 8484, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/332411a0", "pdfUrl": "http://www.nature.com/articles/332411a0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1021/cr900356p", "doi": "10.1021/cr900356p", "title": "Dye-Sensitized Solar Cells", "publicationYear": 2010, "publicationDate": "2010-11-10", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Chemical Reviews", "volume": "110", "issue": "11", "page": "6595-6663", "issn": "0009-2665, 1520-6890", "isbn": null, "authors": "Anders Hagfeldt, Gerrit Boschloo, Licheng Sun, Lars Kloo, Henrik Pettersson", "authorCount": 5, "firstAuthorAffiliation": "Department of Physical and Analytical Chemistry, Uppsala University, Box 259, SE-751 05 Uppsala, Sweden, Department of Chemistry, KTH - Royal Institute of Technology, Teknikringen 30, SE-100 44 Stockholm, Sweden, State Key Laboratory of Fine Chemicals, DUT-KTH Joint Education and Research Centre on Molecular Devices, Dalian University of Technology (DUT), Dalian 116012, China, and Swerea IVF AB, Box 104, SE-431 22 Mölndal, Sweden", "isReferencedByCount": 8447, "referenceCount": 945, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/cr900356p", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1073/pnas.0530291100", "doi": "10.1073/pnas.0530291100", "title": "Prospective identification of tumorigenic breast cancer cells", "publicationYear": 2003, "publicationDate": "2003-04", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "100", "issue": "7", "page": "3983-3988", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Muhammad Al-Hajj, Max S. Wicha, Adalberto Benito-Hernandez, Sean J. Morrison, Michael F. Clarke", "authorCount": 5, "firstAuthorAffiliation": "Departments of Internal Medicine and Pathology, Comprehensive Cancer Center, Department of Developmental Biology, and Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109", "isReferencedByCount": 8332, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.0530291100", "pdfUrl": null, "abstract": "Breast cancer is the most common malignancy in United States women, accounting for &gt;40,000 deaths each year. These breast tumors are comprised of phenotypically diverse populations of breast cancer cells. Using a model in which human breast cancer cells were grown in immunocompromised mice, we found that only a minority of breast cancer cells had the ability to form new tumors. We were able to distinguish the tumorigenic (tumor initiating) from the nontumorigenic cancer cells based on cell surface marker expression. We prospectively identified and isolated the tumorigenic cells as CD44 + CD24 −/low Lineage − in eight of nine patients. As few as 100 cells with this phenotype were able to form tumors in mice, whereas tens of thousands of cells with alternate phenotypes failed to form tumors. The tumorigenic subpopulation could be serially passaged: each time cells within this population generated new tumors containing additional CD44 + CD24 −/low Lineage − tumorigenic cells as well as the phenotypically diverse mixed populations of nontumorigenic cells present in the initial tumor. The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival. Furthermore, because these cells drive tumor development, strategies designed to target this population may lead to more effective therapies.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1073/pnas.0603395103", "doi": "10.1073/pnas.0603395103", "title": "Powering the planet: Chemical challenges in solar energy utilization", "publicationYear": 2006, "publicationDate": "2006-10-24", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "103", "issue": "43", "page": "15729-15735", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Nathan S. Lewis, Daniel G. Nocera", "authorCount": 2, "firstAuthorAffiliation": "*Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125; and", "isReferencedByCount": 7826, "referenceCount": 62, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.0603395103", "pdfUrl": null, "abstract": "Global energy consumption is projected to increase, even in the face of substantial declines in energy intensity, at least 2-fold by midcentury relative to the present because of population and economic growth. This demand could be met, in principle, from fossil energy resources, particularly coal. However, the cumulative nature of CO 2 emissions in the atmosphere demands that holding atmospheric CO 2 levels to even twice their preanthropogenic values by midcentury will require invention, development, and deployment of schemes for carbon-neutral energy production on a scale commensurate with, or larger than, the entire present-day energy supply from all sources combined. Among renewable energy resources, solar energy is by far the largest exploitable resource, providing more energy in 1 hour to the earth than all of the energy consumed by humans in an entire year. In view of the intermittency of insolation, if solar energy is to be a major primary energy source, it must be stored and dispatched on demand to the end user. An especially attractive approach is to store solar-converted energy in the form of chemical bonds, i.e., in a photosynthetic process at a year-round average efficiency significantly higher than current plants or algae, to reduce land-area requirements. Scientific challenges involved with this process include schemes to capture and convert solar energy and then store the energy in the form of chemical bonds, producing oxygen from water and a reduced fuel such as hydrogen, methane, methanol, or other hydrocarbon species.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/35078107", "doi": "10.1038/35078107", "title": "Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells", "publicationYear": 2001, "publicationDate": "2001-05", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "411", "issue": "6836", "page": "494-498", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel, Abdullah Yalcin, Klaus Weber, Thomas Tuschl", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 7630, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/35078107", "pdfUrl": "http://www.nature.com/articles/35078107.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/35102167", "doi": "10.1038/35102167", "title": "Stem cells, cancer, and cancer stem cells", "publicationYear": 2001, "publicationDate": "2001-11", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "414", "issue": "6859", "page": "105-111", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Tannishtha Reya, Sean J. Morrison, Michael F. Clarke, Irving L. Weissman", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 7598, "referenceCount": 85, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/35102167", "pdfUrl": "http://www.nature.com/articles/35102167.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/nature12509", "doi": "10.1038/nature12509", "title": "Efficient planar heterojunction perovskite solar cells by vapour deposition", "publicationYear": 2013, "publicationDate": "2013-09-19", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "501", "issue": "7467", "page": "395-398", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Mingzhen Liu, Michael B. Johnston, Henry J. Snaith", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 7590, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nature12509", "pdfUrl": "http://www.nature.com/articles/nature12509.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/srep00591", "doi": "10.1038/srep00591", "title": "Lead Iodide Perovskite Sensitized All-Solid-State Submicron Thin Film Mesoscopic Solar Cell with Efficiency Exceeding 9%", "publicationYear": 2012, "publicationDate": "2012-08-21", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Scientific Reports", "volume": "2", "issue": "1", "page": null, "issn": "2045-2322", "isbn": null, "authors": "Hui-Seon Kim, Chang-Ryul Lee, Jeong-Hyeok Im, Ki-Beom Lee, Thomas Moehl, Arianna Marchioro, Soo-Jin Moon, Robin Humphry-Baker, Jun-Ho Yum, Jacques E. Moser, Michael Grätzel, Nam-Gyu Park", "authorCount": 12, "firstAuthorAffiliation": null, "isReferencedByCount": 7511, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-sa/3.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/srep00591", "pdfUrl": "https://www.nature.com/articles/srep00591.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1016/0014-4827(68)90403-5", "doi": "10.1016/0014-4827(68)90403-5", "title": "Nutrient requirements of suspension cultures of soybean root cells", "publicationYear": 1968, "publicationDate": "1968-04", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Experimental Cell Research", "volume": "50", "issue": "1", "page": "151-158", "issn": "0014-4827", "isbn": null, "authors": "O.L. Gamborg, R.A. Miller, K. Ojima", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 7304, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/0014-4827(68)90403-5", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1016/j.cell.2008.03.027", "doi": "10.1016/j.cell.2008.03.027", "title": "The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells", "publicationYear": 2008, "publicationDate": "2008-05", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell", "volume": "133", "issue": "4", "page": "704-715", "issn": "0092-8674", "isbn": null, "authors": "Sendurai A. Mani, Wenjun Guo, Mai-Jing Liao, Elinor Ng. Eaton, Ayyakkannu Ayyanan, Alicia Y. Zhou, Mary Brooks, Ferenc Reinhard, Cheng Cheng Zhang, Michail Shipitsin, Lauren L. Campbell, Kornelia Polyak, Cathrin Brisken, Jing Yang, Robert A. Weinberg", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 7233, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.cell.2008.03.027", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/ncomms14049", "doi": "10.1038/ncomms14049", "title": "Massively parallel digital transcriptional profiling of single cells", "publicationYear": 2017, "publicationDate": "2017-01-16", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Communications", "volume": "8", "issue": "1", "page": null, "issn": "2041-1723", "isbn": null, "authors": "Grace X. Y. Zheng, Jessica M. Terry, Phillip Belgrader, Paul Ryvkin, Zachary W. Bent, Ryan Wilson, Solongo B. Ziraldo, Tobias D. Wheeler, Geoff P. McDermott, Junjie Zhu, Mark T. Gregory, Joe Shuga, Luz Montesclaros, Jason G. Underwood, Donald A. Masquelier, Stefanie Y. Nishimura, Michael Schnall-Levin, Paul W. Wyatt, Christopher M. Hindson, Rajiv Bharadwaj, Alexander Wong, Kevin D. Ness, Lan W. Beppu, H. Joachim Deeg, Christopher McFarland, Keith R. Loeb, William J. Valente, Nolan G. Ericson, Emily A. Stevens, Jerald P. Radich, Tarjei S. Mikkelsen, Benjamin J. Hindson, Jason H. Bielas", "authorCount": 33, "firstAuthorAffiliation": null, "isReferencedByCount": 7138, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/ncomms14049", "pdfUrl": "https://www.nature.com/articles/ncomms14049.pdf", "abstract": "Abstract Characterizing the transcriptome of individual cells is fundamental to understanding complex biological systems. We describe a droplet-based system that enables 3′ mRNA counting of tens of thousands of single cells per sample. Cell encapsulation, of up to 8 samples at a time, takes place in ∼6 min, with ∼50% cell capture efficiency. To demonstrate the system’s technical performance, we collected transcriptome data from ∼250k single cells across 29 samples. We validated the sensitivity of the system and its ability to detect rare populations using cell lines and synthetic RNAs. We profiled 68k peripheral blood mononuclear cells to demonstrate the system’s ability to characterize large immune populations. Finally, we used sequence variation in the transcriptome data to determine host and donor chimerism at single-cell resolution from bone marrow mononuclear cells isolated from transplant patients.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1126/science.275.5302.964", "doi": "10.1126/science.275.5302.964", "title": "Isolation of Putative Progenitor Endothelial Cells for Angiogenesis", "publicationYear": 1997, "publicationDate": "1997-02-14", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "275", "issue": "5302", "page": "964-966", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "Takayuki Asahara, Toyoaki Murohara, Alison Sullivan, Marcy Silver, Rien van der Zee, Tong Li, Bernhard Witzenbichler, Gina Schatteman, Jeffrey M. Isner", "authorCount": 9, "firstAuthorAffiliation": "Departments of Medicine (Cardiology) and Biomedical Research, St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA.", "isReferencedByCount": 7130, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.275.5302.964", "pdfUrl": null, "abstract": "Putative endothelial cell (EC) progenitors or angioblasts were isolated from human peripheral blood by magnetic bead selection on the basis of cell surface antigen expression. In vitro, these cells differentiated into ECs. In animal models of ischemia, heterologous, homologous, and autologous EC progenitors incorporated into sites of active angiogenesis. These findings suggest that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarian angiogenesis.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/nbt.2859", "doi": "10.1038/nbt.2859", "title": "The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells", "publicationYear": 2014, "publicationDate": "2014-04", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Biotechnology", "volume": "32", "issue": "4", "page": "381-386", "issn": "1087-0156, 1546-1696", "isbn": null, "authors": "Cole Trapnell, Davide Cacchiarelli, Jonna Grimsby, Prapti Pokharel, Shuqiang Li, Michael Morse, Niall J Lennon, Kenneth J Livak, Tarjei S Mikkelsen, John L Rinn", "authorCount": 10, "firstAuthorAffiliation": null, "isReferencedByCount": 7129, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nbt.2859", "pdfUrl": "http://www.nature.com/articles/nbt.2859.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1016/j.cell.2015.05.002", "doi": "10.1016/j.cell.2015.05.002", "title": "Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets", "publicationYear": 2015, "publicationDate": "2015-05", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell", "volume": "161", "issue": "5", "page": "1202-1214", "issn": "0092-8674", "isbn": null, "authors": "Evan Z. Macosko, Anindita Basu, Rahul Satija, James Nemesh, Karthik Shekhar, Melissa Goldman, Itay Tirosh, Allison R. Bialas, Nolan Kamitaki, Emily M. Martersteck, John J. Trombetta, David A. Weitz, Joshua R. Sanes, Alex K. Shalek, Aviv Regev, Steven A. McCarroll", "authorCount": 16, "firstAuthorAffiliation": null, "isReferencedByCount": 7084, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.cell.2015.05.002", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/nphoton.2014.134", "doi": "10.1038/nphoton.2014.134", "title": "The emergence of perovskite solar cells", "publicationYear": 2014, "publicationDate": "2014-07", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Photonics", "volume": "8", "issue": "7", "page": "506-514", "issn": "1749-4885, 1749-4893", "isbn": null, "authors": "Martin A. Green, Anita Ho-Baillie, Henry J. Snaith", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 7075, "referenceCount": 99, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nphoton.2014.134", "pdfUrl": "http://www.nature.com/articles/nphoton.2014.134.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1126/science.1104274", "doi": "10.1126/science.1104274", "title": "Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics", "publicationYear": 2005, "publicationDate": "2005-01-28", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "307", "issue": "5709", "page": "538-544", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "X. Michalet, F. F. Pinaud, L. A. Bentolila, J. M. Tsay, S. Doose, J. J. Li, G. Sundaresan, A. M. Wu, S. S. Gambhir, S. Weiss", "authorCount": 10, "firstAuthorAffiliation": "Department of Chemistry and Biochemistry, University of California, 607 Charles E. Young Drive East, Los Angeles, CA 90095, USA.", "isReferencedByCount": 7038, "referenceCount": 83, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.1104274", "pdfUrl": null, "abstract": "Research on fluorescent semiconductor nanocrystals (also known as quantum dots or qdots) has evolved over the past two decades from electronic materials science to biological applications. We review current approaches to the synthesis, solubilization, and functionalization of qdots and their applications to cell and animal biology. Recent examples of their experimental use include the observation of diffusion of individual glycine receptors in living neurons and the identification of lymph nodes in live animals by near-infrared emission during surgery. The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1021/cr020730k", "doi": "10.1021/cr020730k", "title": "What Are Batteries, Fuel Cells, and Supercapacitors?", "publicationYear": 2004, "publicationDate": "2004-10-01", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Chemical Reviews", "volume": "104", "issue": "10", "page": "4245-4270", "issn": "0009-2665, 1520-6890", "isbn": null, "authors": "Martin Winter, Ralph J. Brodd", "authorCount": 2, "firstAuthorAffiliation": "Institute for Chemistry and Technology of Inorganic Materials, Graz University of Technology, Stremayrgasse 16, A-8010 Graz, Austria", "isReferencedByCount": 6794, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/cr020730k", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1016/j.physletb.2012.08.020", "doi": "10.1016/j.physletb.2012.08.020", "title": "Observation of a new particle in the search for the Standard Model Higgs boson with the ATLAS detector at the LHC", "publicationYear": 2012, "publicationDate": "2012-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Physics Letters B", "volume": "716", "issue": "1", "page": "1-29", "issn": "0370-2693", "isbn": null, "authors": "G. Aad, T. Abajyan, B. Abbott, J. Abdallah, S. Abdel Khalek, A.A. Abdelalim, O. Abdinov, R. Aben, B. Abi, M. Abolins, O.S. AbouZeid, H. Abramowicz, H. Abreu, B.S. Acharya, L. Adamczyk, D.L. Adams, T.N. Addy, J. Adelman, S. Adomeit, P. Adragna, T. Adye, S. Aefsky, J.A. Aguilar-Saavedra, M. Agustoni, M. Aharrouche, S.P. Ahlen, F. Ahles, A. Ahmad, M. Ahsan, G. Aielli, T. Akdogan, T.P.A. Åkesson, G. Akimoto, A.V. Akimov, M.S. Alam, M.A. Alam, J. Albert, S. Albrand, M. Aleksa, I.N. Aleksandrov, F. Alessandria, C. Alexa, G. Alexander, G. Alexandre, T. Alexopoulos, M. Alhroob, M. Aliev, G. Alimonti, J. Alison, B.M.M. Allbrooke, P.P. Allport, S.E. Allwood-Spiers, J. Almond, A. Aloisio, R. Alon, A. Alonso, F. Alonso, A. Altheimer, B. Alvarez Gonzalez, M.G. Alviggi, K. Amako, C. Amelung, V.V. Ammosov, S.P. Amor Dos Santos, A. Amorim, N. Amram, C. Anastopoulos, L.S. Ancu, N. Andari, T. Andeen, C.F. Anders, G. Anders, K.J. Anderson, A. Andreazza, V. Andrei, M.-L. Andrieux, X.S. Anduaga, S. Angelidakis, P. Anger, A. Angerami, F. Anghinolfi, A. Anisenkov, N. Anjos, A. Annovi, A. Antonaki, M. Antonelli, A. Antonov, J. Antos, F. Anulli, M. Aoki, S. Aoun, L. Aperio Bella, R. Apolle, G. Arabidze, I. Aracena, Y. Arai, A.T.H. Arce, S. Arfaoui, J.-F. Arguin, E. Arik, M. Arik, A.J. Armbruster, O. Arnaez, V. Arnal, C. Arnault, A. Artamonov, G. Artoni, D. Arutinov, S. Asai, S. Ask, B. Åsman, L. Asquith, K. Assamagan, A. Astbury, M. Atkinson, B. Aubert, E. Auge, K. Augsten, M. Aurousseau, G. Avolio, R. Avramidou, D. Axen, G. Azuelos, Y. Azuma, M.A. Baak, G. Baccaglioni, C. Bacci, A.M. Bach, H. Bachacou, K. Bachas, M. Backes, M. Backhaus, J. Backus Mayes, E. Badescu, P. Bagnaia, S. Bahinipati, Y. Bai, D.C. Bailey, T. Bain, J.T. Baines, O.K. Baker, M.D. Baker, S. Baker, P. Balek, E. Banas, P. Banerjee, Sw. Banerjee, D. Banfi, A. Bangert, V. Bansal, H.S. Bansil, L. Barak, S.P. Baranov, A. Barbaro Galtieri, T. Barber, E.L. Barberio, D. Barberis, M. Barbero, D.Y. Bardin, T. Barillari, M. Barisonzi, T. Barklow, N. Barlow, B.M. Barnett, R.M. Barnett, A. Baroncelli, G. Barone, A.J. Barr, F. Barreiro, J. Barreiro Guimarães da Costa, P. Barrillon, R. Bartoldus, A.E. Barton, V. Bartsch, A. Basye, R.L. Bates, L. Batkova, J.R. Batley, A. Battaglia, M. Battistin, F. Bauer, H.S. Bawa, S. Beale, T. Beau, P.H. Beauchemin, R. Beccherle, P. Bechtle, H.P. Beck, A.K. Becker, S. Becker, M. Beckingham, K.H. Becks, A.J. Beddall, A. Beddall, S. Bedikian, V.A. Bednyakov, C.P. Bee, L.J. Beemster, M. Begel, S. Behar Harpaz, P.K. Behera, M. Beimforde, C. Belanger-Champagne, P.J. Bell, W.H. Bell, G. Bella, L. Bellagamba, M. Bellomo, A. Belloni, O. Beloborodova, K. Belotskiy, O. Beltramello, O. Benary, D. Benchekroun, K. Bendtz, N. Benekos, Y. Benhammou, E. Benhar Noccioli, J.A. Benitez Garcia, D.P. Benjamin, M. Benoit, J.R. Bensinger, K. Benslama, S. Bentvelsen, D. Berge, E. Bergeaas Kuutmann, N. Berger, F. Berghaus, E. Berglund, J. Beringer, P. Bernat, R. Bernhard, C. Bernius, F.U. Bernlochner, T. Berry, C. Bertella, A. Bertin, F. Bertolucci, M.I. Besana, G.J. Besjes, N. Besson, S. Bethke, W. Bhimji, R.M. Bianchi, M. Bianco, O. Biebel, S.P. Bieniek, K. Bierwagen, J. Biesiada, M. Biglietti, H. Bilokon, M. Bindi, S. Binet, A. Bingul, C. Bini, C. Biscarat, B. Bittner, K.M. Black, R.E. Blair, J.-B. Blanchard, G. Blanchot, T. Blazek, I. Bloch, C. Blocker, J. Blocki, A. Blondel, W. Blum, U. Blumenschein, G.J. Bobbink, V.B. Bobrovnikov, S.S. Bocchetta, A. Bocci, C.R. Boddy, M. Boehler, J. Boek, N. Boelaert, J.A. Bogaerts, A. 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{"paperId": "10.1038/nature07935", "doi": "10.1038/nature07935", "title": "Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche", "publicationYear": 2009, "publicationDate": "2009-05", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "459", "issue": "7244", "page": "262-265", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Toshiro Sato, Robert G. Vries, Hugo J. Snippert, Marc van de Wetering, Nick Barker, Daniel E. Stange, Johan H. van Es, Arie Abo, Pekka Kujala, Peter J. Peters, Hans Clevers", "authorCount": 11, "firstAuthorAffiliation": null, "isReferencedByCount": 6610, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nature07935", "pdfUrl": "http://www.nature.com/articles/nature07935.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1089/107632701300062859", "doi": "10.1089/107632701300062859", "title": "Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies", "publicationYear": 2001, "publicationDate": "2001-04", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Tissue Engineering", "volume": "7", "issue": "2", "page": "211-228", "issn": "1076-3279, 1557-8690", "isbn": null, "authors": "Patricia A. Zuk, Min Zhu, Hiroshi Mizuno, Jerry Huang, J. William Futrell, Adam J. Katz, Prosper Benhaim, H. Peter Lorenz, Marc H. Hedrick", "authorCount": 9, "firstAuthorAffiliation": "Laboratory for Regenerative Bioengineering and Repair, Departments of Surgery and Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, California", "isReferencedByCount": 6485, "referenceCount": 88, "isOpenAccess": true, "licenseUrl": "https://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1089/107632701300062859", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1103/physrev.82.403", "doi": "10.1103/physrev.82.403", "title": "Interaction between the<mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" display=\"inline\"><mml:mi>d</mml:mi></mml:math>-Shells in the Transition Metals. II. Ferromagnetic Compounds of Manganese with Perovskite Structure", "publicationYear": 1951, "publicationDate": "1951-05-01", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Physical Review", "volume": "82", "issue": "3", "page": "403-405", "issn": "0031-899X", "isbn": null, "authors": "Clarence Zener", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 6480, "referenceCount": 4, "isOpenAccess": true, "licenseUrl": "http://link.aps.org/licenses/aps-default-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1103/physrev.82.403", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1038/nmat4014", "doi": "10.1038/nmat4014", "title": "Solvent engineering for high-performance inorganic–organic hybrid perovskite solar cells", "publicationYear": 2014, "publicationDate": "2014-09", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Materials", "volume": "13", "issue": "9", "page": "897-903", "issn": "1476-1122, 1476-4660", "isbn": null, "authors": "Nam Joong Jeon, Jun Hong Noh, Young Chan Kim, Woon Seok Yang, Seungchan Ryu, Sang Il Seok", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 6447, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nmat4014", "pdfUrl": "https://www.nature.com/articles/nmat4014.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1073/pnas.92.20.9363", "doi": "10.1073/pnas.92.20.9363", "title": "A biomarker that identifies senescent human cells in culture and in aging skin in vivo.", "publicationYear": 1995, "publicationDate": "1995-09-26", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "92", "issue": "20", "page": "9363-9367", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "G P Dimri, X Lee, G Basile, M Acosta, G Scott, C Roskelley, E E Medrano, M Linskens, I Rubelj, O Pereira-Smith", "authorCount": 10, "firstAuthorAffiliation": "Department of Cell and Molecular Biology, Lawrence Berkeley Laboratory, University of California, Berkeley 94720, USA.", "isReferencedByCount": 6418, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.92.20.9363", "pdfUrl": null, "abstract": "Normal somatic cells invariably enter a state of irreversibly arrested growth and altered function after a finite number of divisions. This process, termed replicative senescence, is thought to be a tumor-suppressive mechanism and an underlying cause of aging. There is ample evidence that escape from senescence, or immortality, is important for malignant transformation. By contrast, the role of replicative senescence in organismic aging is controversial. Studies on cells cultured from donors of different ages, genetic backgrounds, or species suggest that senescence occurs in vivo and that organismic lifespan and cell replicative lifespan are under common genetic control. However, senescent cells cannot be distinguished from quiescent or terminally differentiated cells in tissues. Thus, evidence that senescent cells exist and accumulate with age in vivo is lacking. We show that several human cells express a beta-galactosidase, histochemically detectable at pH 6, upon senescence in culture. This marker was expressed by senescent, but not presenescent, fibroblasts and keratinocytes but was absent from quiescent fibroblasts and terminally differentiated keratinocytes. It was also absent from immortal cells but was induced by genetic manipulations that reversed immortality. In skin samples from human donors of different age, there was an age-dependent increase in this marker in dermal fibroblasts and epidermal keratinocytes. This marker provides in situ evidence that senescent cells may exist and accumulate with age in vivo.", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1126/science.1254050", "doi": "10.1126/science.1254050", "title": "Interface engineering of highly efficient perovskite solar cells", "publicationYear": 2014, "publicationDate": "2014-08", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "345", "issue": "6196", "page": "542-546", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "Huanping Zhou, Qi Chen, Gang Li, Song Luo, Tze-bing Song, Hsin-Sheng Duan, Ziruo Hong, Jingbi You, Yongsheng Liu, Yang Yang", "authorCount": 10, "firstAuthorAffiliation": "Department of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.", "isReferencedByCount": 6383, "referenceCount": 40, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.1254050", "pdfUrl": null, "abstract": "A layered approach improves solar cells Perovskite films received a boost in photovoltaic efficiency through controlled formation of charge-generating films and improved current transfer to the electrodes. Zhou et al. lowered the defect density of the film by controlling humidity while the perovskite film formed from lead chloride and methylammonium iodide. Low-temperature processing steps allowed the use of materials that draw current out of the perovskite layer more efficiently. These and other modifications enabled a maximum cell efficiency of just over 19% and an average of 16.6%. Science , this issue p. 542", "subject": null, "language": "en", "_run_id": "7zl0krbjJ1OkuPPPi", "_dataset_id": "xgppXZgA31eRpsd9U"}
{"paperId": "10.1016/j.xhgg.2022.100143", "doi": "10.1016/j.xhgg.2022.100143", "title": "A scalable Bayesian functional GWAS method accounting for multivariate quantitative functional annotations with applications for studying Alzheimer disease", "publicationYear": 2022, "publicationDate": "2022-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Human Genetics and Genomics Advances", "volume": "3", "issue": "4", "page": "100143", "issn": "2666-2477", "isbn": null, "authors": "Junyu Chen, Lei Wang, Philip L. De Jager, David A. Bennett, Aron S. Buchman, Jingjing Yang", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 65, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, National Institute on Aging, Translational Genomics Research Institute, Translational Genomics Research Institute, Translational Genomics Research Institute, Translational Genomics Research Institute, Translational Genomics Research Institute, Translational Genomics Research Institute, Translational Genomics Research Institute, Translational Genomics Research Institute, Translational Genomics Research Institute, Mayo Foundation for Medical Education and Research, Illinois Department of Public Health, National Institutes of Health, NIGMS, National Institute of Neurological Disorders and Stroke", "funderIds": "10.13039/100000049, 10.13039/100000049, 10.13039/100000049, 10.13039/100000049, 10.13039/100000049, 10.13039/100000049, 10.13039/100000049, 10.13039/100000049, 10.13039/100000049, 10.13039/100017803, 10.13039/100017803, 10.13039/100017803, 10.13039/100017803, 10.13039/100017803, 10.13039/100017803, 10.13039/100017803, 10.13039/100017803, 10.13039/100017803, 10.13039/100007048, 10.13039/100004888, 10.13039/100000002, 10.13039/100000057, 10.13039/100000065", "url": "https://doi.org/10.1016/j.xhgg.2022.100143", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-017-4171-y", "doi": "10.1186/s12864-017-4171-y", "title": "Identification of 15 candidate structured noncoding RNA motifs in fungi by comparative genomics", "publicationYear": 2017, "publicationDate": "2017-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "18", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Sanshu Li, Ronald R. Breaker", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 18, "referenceCount": 99, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Institutes of Health, Howard Hughes Medical Institute", "funderIds": "10.13039/100000002, 10.13039/100000011", "url": "https://doi.org/10.1186/s12864-017-4171-y", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s12864-017-4171-y.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-025-11398-z", "doi": "10.1186/s12864-025-11398-z", "title": "Large indel detection in region-based phased diploid assemblies from linked-reads", "publicationYear": 2025, "publicationDate": "2025-03-18", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "26", "issue": "S2", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Can Luo, Brock A. Peters, Xin Maizie Zhou", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 35, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "National Institutes of Health, Complete Genomics", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s12864-025-11398-z", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s12864-025-11398-z.pdf", "abstract": "Abstract Background Linked-reads improve de novo assembly, haplotype phasing, structural variant (SV) detection, and other applications through highly-multiplexed genome partitioning and barcoding. Whole genome assembly and assembly-based variant detection based on linked-reads often require intensive computation costs and are not suitable for large population studies. Here we propose an efficient pipeline, RegionIndel, a region-based diploid assembly approach to characterize large indel SVs. This pipeline only focuses on target regions (50kb by default) to extract barcoded reads as input and then integrates a haplotyping algorithm and local assembly to generate phased diploid contiguous sequences (contigs). Finally, it detects variants in the contigs through a pairwise contig-to-reference comparison. Results We applied RegionIndel on two linked-reads libraries of sample HG002, one using 10x and the other stLFR. HG002 is a well-studied sample and the Genome in a Bottle (GiaB) community provides a gold standard SV set for it. RegionIndel outperformed several assembly and alignment-based SV callers in our benchmark experiments. After assembling all indel SVs, RegionIndel achieved an overall F1 score of 74.8% in deletions and 61.8% in insertions for 10x linked-reads, and 64.3% in deletions and 36.7% in insertions for stLFR linked-reads, respectively. Furthermore, it achieved an overall genotyping accuracy of 83.6% and 80.8% for 10x and stLFR linked-reads, respectively. Conclusions RegionIndel can achieve diploid assembly and detect indel SVs in each target region. The phased diploid contigs can further allow us to investigate indel SVs with nearby linked single nucleotide polymorphism (SNPs) and small indels in the same haplotype.", "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.ygeno.2014.08.005", "doi": "10.1016/j.ygeno.2014.08.005", "title": "The role of DNA repair in herpesvirus pathogenesis", "publicationYear": 2014, "publicationDate": "2014-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Genomics", "volume": "104", "issue": "4", "page": "287-294", "issn": "0888-7543", "isbn": null, "authors": "Jay C. Brown", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 17, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "NIH", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.ygeno.2014.08.005", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-023-09643-4", "doi": "10.1186/s12864-023-09643-4", "title": "The NIH Comparative Genomics Resource: addressing the promises and challenges of comparative genomics on human health", "publicationYear": 2023, "publicationDate": "2023-09-27", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "24", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Kristin Bornstein, Gary Gryan, E. Sally Chang, Aron Marchler-Bauer, Valerie A. Schneider", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 33, "referenceCount": 110, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "National Center for Biotechnology Information (NCBI) of the National Library of Medicine (NLM), National Institutes of Health, National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s12864-023-09643-4", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s12864-023-09643-4.pdf", "abstract": "AbstractComparative genomics is the comparison of genetic information within and across organisms to understand the evolution, structure, and function of genes, proteins, and non-coding regions (Sivashankari and Shanmughavel, Bioinformation 1:376-8, 2007). Advances in sequencing technology and assembly algorithms have resulted in the ability to sequence large genomes and provided a wealth of data that are being used in comparative genomic analyses. Comparative analysis can be leveraged to systematically explore and evaluate the biological relationships and evolution between species, aid in understanding the structure and function of genes, and gain a better understanding of disease and potential drug targets. As our knowledge of genetics expands, comparative genomics can help identify emerging model organisms among a broader span of the tree of life, positively impacting human health. This impact includes, but is not limited to, zoonotic disease research, therapeutics development, microbiome research, xenotransplantation, oncology, and toxicology. Despite advancements in comparative genomics, new challenges have arisen around the quantity, quality assurance, annotation, and interoperability of genomic data and metadata. New tools and approaches are required to meet these challenges and fulfill the needs of researchers. This paper focuses on how the National Institutes of Health (NIH) Comparative Genomics Resource (CGR) can address both the opportunities for comparative genomics to further impact human health and confront an increasingly complex set of challenges facing researchers.", "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-025-12023-9", "doi": "10.1186/s12864-025-12023-9", "title": "SoMaCX: a complex generative genome modeling framework", "publicationYear": 2025, "publicationDate": "2025-09-29", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "26", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Timothy James Becker", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s12864-025-12023-9", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s12864-025-12023-9.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.ygeno.2010.10.005", "doi": "10.1016/j.ygeno.2010.10.005", "title": "Transcriptional regulation of mammalian miRNA genes", "publicationYear": 2011, "publicationDate": "2011-01", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Genomics", "volume": "97", "issue": "1", "page": "1-6", "issn": "0888-7543", "isbn": null, "authors": "Brian C. Schanen, Xiaoman Li", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 145, "referenceCount": 62, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.ygeno.2010.10.005", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.gdata.2015.06.004", "doi": "10.1016/j.gdata.2015.06.004", "title": "Neurotranscriptome profiles of multiple zebrafish strains", "publicationYear": 2015, "publicationDate": "2015-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Genomics Data", "volume": "5", "issue": null, "page": "206-209", "issn": "2213-5960", "isbn": null, "authors": "Ryan Y. Wong, John Godwin", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 22, "referenceCount": 15, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.gdata.2015.06.004", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-015-1604-3", "doi": "10.1186/s12864-015-1604-3", "title": "Controlling for conservation in genome-wide DNA methylation studies", "publicationYear": 2015, "publicationDate": "2015-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "16", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Meromit Singer, Lior Pachter", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 54, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s12864-015-1604-3", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s12864-015-1604-3.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-018-4540-1", "doi": "10.1186/s12864-018-4540-1", "title": "Finding RNA structure in the unstructured RBPome", "publicationYear": 2018, "publicationDate": "2018-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "19", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Yaron Orenstein, Uwe Ohler, Bonnie Berger", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 10, "referenceCount": 22, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s12864-018-4540-1", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s12864-018-4540-1.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1093/bfgp/ely002", "doi": "10.1093/bfgp/ely002", "title": "Integrating ChIP-seq with other functional genomics data", "publicationYear": 2018, "publicationDate": "2018-03-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Briefings in Functional Genomics", "volume": "17", "issue": "2", "page": "104-115", "issn": "2041-2649, 2041-2657", "isbn": null, "authors": "Shan Jiang, Ali Mortazavi", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 78, "referenceCount": 167, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/4.0/", "funderNames": "NIH", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1093/bfgp/ely002", "pdfUrl": "http://academic.oup.com/bfg/article-pdf/17/2/104/25082473/ely002.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.xgen.2024.100741", "doi": "10.1016/j.xgen.2024.100741", "title": "Double or nothing: Ancient duplications in the amylase locus drove human adaptation", "publicationYear": 2025, "publicationDate": "2025-01", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Genomics", "volume": "5", "issue": "1", "page": "100741", "issn": "2666-979X", "isbn": null, "authors": "Shahar Silverman, Diyendo Massilani", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 8, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "NIH", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.xgen.2024.100741", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.xgen.2023.100403", "doi": "10.1016/j.xgen.2023.100403", "title": "Better together: Non-additive interactions between schizophrenia risk genes", "publicationYear": 2023, "publicationDate": "2023-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Genomics", "volume": "3", "issue": "9", "page": "100403", "issn": "2666-979X", "isbn": null, "authors": "P.J. Michael Deans, Kristen J. Brennand", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 9, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "NIH", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.xgen.2023.100403", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.atg.2013.08.001", "doi": "10.1016/j.atg.2013.08.001", "title": "Disease consequences of human adaptation", "publicationYear": 2013, "publicationDate": "2013-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Applied &amp; Translational Genomics", "volume": "2", "issue": null, "page": "42-47", "issn": "2212-0661", "isbn": null, "authors": "Justin C. Fay", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 13, "referenceCount": 88, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.atg.2013.08.001", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1101/2025.06.05.654938", "doi": "10.1101/2025.06.05.654938", "title": "CrossFilt: A Cross-species Filtering Tool that Eliminates Alignment Bias in Comparative Genomics Studies", "publicationYear": 2025, "publicationDate": "2025-06-06", "type": "posted-content", "publisher": "openRxiv", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Kenneth A. Barr, Yoav Gilad", "authorCount": 2, "firstAuthorAffiliation": "Department of Medicine, University of Chicago; Chicago, IL 60637, USA", "isReferencedByCount": 1, "referenceCount": 57, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/4.0/", "funderNames": "National Institutes of Health, National Institutes of Health", "funderIds": "10.13039/100000002, 10.13039/100000002", "url": "https://doi.org/10.1101/2025.06.05.654938", "pdfUrl": null, "abstract": "Abstract Comparative functional genomic studies are often affected by biased read mapping across species due to inter-species differences in genome structure, sequence composition, and annotation quality. We developed CrossFilt, a filtering strategy that retains only sequencing reads that map reciprocally between genomes, ensuring that quantification of read counts is based on directly comparable genomic features. Using both real and simulated RNA-sequencing data from primates, we show that CrossFilt outperforms five alternative approaches that are commonly used, resulting in more accurate inference of gene expression differences. Our results highlight the impact of preprocessing strategies on the analysis of cross-species functional genomics data.", "subject": null, "language": null, "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s40246-015-0040-4", "doi": "10.1186/s40246-015-0040-4", "title": "Predicting the combined effect of multiple genetic variants", "publicationYear": 2015, "publicationDate": "2015-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Human Genomics", "volume": "9", "issue": "1", "page": null, "issn": "1479-7364", "isbn": null, "authors": "Mingming Liu, Layne T. Watson, Liqing Zhang", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 16, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s40246-015-0040-4", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s40246-015-0040-4.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.xhgg.2025.100424", "doi": "10.1016/j.xhgg.2025.100424", "title": "Using genetics, genomics, and transcriptomics to identify therapeutic targets in juvenile idiopathic arthritis", "publicationYear": 2025, "publicationDate": "2025-04", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Human Genetics and Genomics Advances", "volume": "6", "issue": "2", "page": "100424", "issn": "2666-2477", "isbn": null, "authors": "Evan Tarbell, James N. Jarvis", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Rheumatology Research Foundation, National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases", "funderIds": "10.13039/100006260, 10.13039/100000002, 10.13039/100000069", "url": "https://doi.org/10.1016/j.xhgg.2025.100424", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.xgen.2023.100278", "doi": "10.1016/j.xgen.2023.100278", "title": "Leveraging our common African origins to understand human evolution and health", "publicationYear": 2023, "publicationDate": "2023-03", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Genomics", "volume": "3", "issue": "3", "page": "100278", "issn": "2666-979X", "isbn": null, "authors": "Ambroise Wonkam, Adebowale Adeyemo", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 8, "referenceCount": 9, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.xgen.2023.100278", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.ygeno.2014.08.015", "doi": "10.1016/j.ygeno.2014.08.015", "title": "5-Hydroxymethylcytosine: A stable or transient DNA modification?", "publicationYear": 2014, "publicationDate": "2014-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Genomics", "volume": "104", "issue": "5", "page": "314-323", "issn": "0888-7543", "isbn": null, "authors": "Maria A. Hahn, Piroska E. Szabó, Gerd P. Pfeifer", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 122, "referenceCount": 120, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "NIH, NIH", "funderIds": "10.13039/100000002, 10.13039/100000002", "url": "https://doi.org/10.1016/j.ygeno.2014.08.015", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.xgen.2023.100358", "doi": "10.1016/j.xgen.2023.100358", "title": "Sampling a wide swathe of primate genetic diversity", "publicationYear": 2023, "publicationDate": "2023-07", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Genomics", "volume": "3", "issue": "7", "page": "100358", "issn": "2666-979X", "isbn": null, "authors": "Evan E. Eichler", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institutes of Health, Howard Hughes Medical Institute", "funderIds": "10.13039/100000002, 10.13039/100000011", "url": "https://doi.org/10.1016/j.xgen.2023.100358", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-024-10317-y", "doi": "10.1186/s12864-024-10317-y", "title": "Tissue-specific atlas of trans-models for gene regulation elucidates complex regulation patterns", "publicationYear": 2024, "publicationDate": "2024-04-17", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "25", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Robert Dagostino, Assaf Gottlieb", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 109, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s12864-024-10317-y", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s12864-024-10317-y.pdf", "abstract": "AbstractBackgroundDeciphering gene regulation is essential for understanding the underlying mechanisms of healthy and disease states. While the regulatory networks formed by transcription factors (TFs) and their target genes has been mostly studied with relation tociseffects such as in TF binding sites, we focused ontranseffects of TFs on the expression of their transcribed genes and their potential mechanisms.ResultsWe provide a comprehensive tissue-specific atlas, spanning 49 tissues of TF variations affecting gene expression through computational models considering two potential mechanisms, including combinatorial regulation by the expression of the TFs, and by genetic variants within the TF.We demonstrate that similarity between tissues based on our discovered genes corresponds to other types of tissue similarity. The genes affected by complex TF regulation, and their modelled TFs, were highly enriched for pharmacogenomic functions, while the TFs themselves were also enriched in several cancer and metabolic pathways. Additionally, genes that appear in multiple clusters are enriched for regulation of immune system while tissue clusters include cluster-specific genes that are enriched for biological functions and diseases previously associated with the tissues forming the cluster. Finally, our atlas exposes multilevel regulation across multiple tissues, where TFs regulate other TFs through the two tested mechanisms.ConclusionsOur tissue-specific atlas provides hierarchical tissue-specifictransgenetic regulations that can be further studied for association with human phenotypes.", "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-016-3307-9", "doi": "10.1186/s12864-016-3307-9", "title": "The Drosophila transcriptional network is structured by microbiota", "publicationYear": 2016, "publicationDate": "2016-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "17", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Adam J. Dobson, John M. Chaston, Angela E. Douglas", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 49, "referenceCount": 39, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s12864-016-3307-9", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s12864-016-3307-9.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-019-6072-8", "doi": "10.1186/s12864-019-6072-8", "title": "Deciphering epigenomic code for cell differentiation using deep learning", "publicationYear": 2019, "publicationDate": "2019-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "20", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Pengyu Ni, Zhengchang Su", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 61, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Science Foundation, National Institutes of Health", "funderIds": "10.13039/100000001, 10.13039/100000002", "url": "https://doi.org/10.1186/s12864-019-6072-8", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s12864-019-6072-8.pdf", "abstract": "Abstract Background Although DNA sequence plays a crucial role in establishing the unique epigenome of a cell type, little is known about the sequence determinants that lead to the unique epigenomes of different cell types produced during cell differentiation. To fill this gap, we employed two types of deep convolutional neural networks (CNNs) constructed for each of differentially related cell types and for each of histone marks measured in the cells, to learn the sequence determinants of various histone modification patterns in each cell type. Results We applied our models to four differentially related human CD 4 + T cell types and six histone marks measured in each cell type. The cell models can accurately predict the histone marks in each cell type, while the mark models can also accurately predict the cell types based on a single mark. Sequence motifs learned by both the cell or mark models are highly similar to known binding motifs of transcription factors known to play important roles in CD 4 + T cell differentiation. Both the unique histone mark patterns in each cell type and the different patterns of the same histone mark in different cell types are determined by a set of motifs with unique combinations. Interestingly, the level of sharing motifs learned in the different cell models reflects the lineage relationships of the cells, while the level of sharing motifs learned in the different histone mark models reflects their functional relationships. These models can also enable the prediction of the importance of learned motifs and their interactions in determining specific histone mark patterns in the cell types. Conclusion Sequence determinants of various histone modification patterns in different cell types can be revealed by comparative analysis of motifs learned in the CNN models for multiple cell types and histone marks. The learned motifs are interpretable and may provide insights into the underlying molecular mechanisms of establishing the unique epigenomes in different cell types. Thus, our results support the hypothesis that DNA sequences ultimately determine the unique epigenomes of different cell types through their interactions with transcriptional factors, epigenome remodeling system and extracellular cues during cell differentiation.", "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.ygeno.2012.06.001", "doi": "10.1016/j.ygeno.2012.06.001", "title": "Identification of imprinting regulators at the Meg3 differentially methylated region", "publicationYear": 2012, "publicationDate": "2012-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Genomics", "volume": "100", "issue": "3", "page": "184-194", "issn": "0888-7543", "isbn": null, "authors": "Erin N. McMurray, Jennifer V. Schmidt", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 20, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.ygeno.2012.06.001", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-025-11374-7", "doi": "10.1186/s12864-025-11374-7", "title": "Data-driven projections of candidate enhancer-activating SNPs in immune regulation", "publicationYear": 2025, "publicationDate": "2025-02-26", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "26", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Markus Hoffmann, Tiago Vaz, Shreeti Chhatrala, Lothar Hennighausen", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 78, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s12864-025-11374-7", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s12864-025-11374-7.pdf", "abstract": "Abstract Background Millions of single nucleotide polymorphisms (SNPs) have been identified in humans, but the functionality of almost all SNPs remains unclear. While current research focuses primarily on SNPs altering one amino acid to another one, the majority of SNPs are located in intergenic spaces. Some of these SNPs can be found in candidate cis-regulatory elements (CREs) such as promoters and enhancers, potentially destroying or creating DNA-binding motifs for transcription factors (TFs) and, hence, deregulating the expression of nearby genes. These aspects are understudied due to the sheer number of SNPs and TF binding motifs, making it challenging to identify SNPs that yield phenotypic changes or altered gene expression. Results We developed a data-driven computational protocol to prioritize high-potential SNPs informed from former knowledge for experimental validation. We evaluated the protocol by investigating SNPs in CREs in the Janus kinase (JAK) – Signal Transducer and Activator of Transcription (-STAT) signaling pathway, which is activated by a plethora of cytokines and crucial in controlling immune responses and has been implicated in diseases like cancer, autoimmune disorders, and responses to viral infections. The protocol involves scanning the entire human genome (hg38) to pinpoint DNA sequences that deviate by only one nucleotide from the canonical binding sites (TTCnnnGAA) for STAT TFs. We narrowed down from an initial pool of 3,301,512 SNPs across 17,039,967 nearly complete STAT motifs and identified six potential gain-of-function SNPs in regions likely to influence regulation within the JAK-STAT pathway. This selection was guided by publicly available open chromatin and gene expression data and further refined by filtering for proximity to immune response genes and conservation between the mouse and human genomes. Conclusion Our findings highlight the value of combining genomic, epigenomic, and cross-species conservation data to effectively narrow down millions of SNPs to a smaller number with a high potential to induce interferon regulation of nearby genes. These SNPs can finally be reviewed manually, laying the groundwork for a more focused and efficient exploration of regulatory SNPs in an experimental setting.", "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s40246-024-00677-7", "doi": "10.1186/s40246-024-00677-7", "title": "Implementing differentially pigmented skin models for predicting drug response variability across human ancestries", "publicationYear": 2024, "publicationDate": "2024-10-09", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Human Genomics", "volume": "18", "issue": "1", "page": null, "issn": "1479-7364", "isbn": null, "authors": "Sophie Zaaijer, Simon C. Groen", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 60, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s40246-024-00677-7", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s40246-024-00677-7.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-016-2696-0", "doi": "10.1186/s12864-016-2696-0", "title": "Inference of kinship using spatial distributions of SNPs for genome-wide association studies", "publicationYear": 2016, "publicationDate": "2016-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "17", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Hyokyeong Lee, Liang Chen", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s12864-016-2696-0", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s12864-016-2696-0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-020-6766-y", "doi": "10.1186/s12864-020-6766-y", "title": "Decoupling behavioral and transcriptional responses to color in an eyeless cnidarian", "publicationYear": 2020, "publicationDate": "2020-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "21", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Whitney B. Leach, Adam M. Reitzel", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 17, "referenceCount": 90, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s12864-020-6766-y", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s12864-020-6766-y.pdf", "abstract": "AbstractBackgroundAnimals have specific molecular, physiological, and behavioral responses to light that are influenced by wavelength and intensity. Predictable environmental changes – predominantly solar and lunar cycles – drive endogenous daily oscillations by setting internal pacemakers, otherwise known as the circadian clock. Cnidarians have been a focal group to discern the evolution of light responsiveness due to their phylogenetic position as a sister phylum to bilaterians and broad range of light-responsive behaviors and physiology. Marine species that occupy a range of depths will experience different ranges of wavelengths and light intensities, which may result in variable phenotypic responses. Here, we utilize the eyeless sea anemoneNematostella vectensis, an estuarine anemone that typically resides in shallow water habitats, to compare behavioral and molecular responses when exposed to different light conditions.ResultsQuantitative measures of locomotion clearly showed that this species responds to light in the blue and green spectral range with a circadian activity profile, in contrast to a circatidal activity profile in the red spectral range and in constant darkness. Differences in average day/night locomotion was significant in each condition, with overall peak activity during the dark period. Comparative analyses of 96 transcriptomes from individuals sampled every 4 h in each lighting treatment revealed complex differences in gene expression between colors, including in many of the genes likely involved in the cnidarian circadian clock. Transcriptional profiling showed the majority of genes are differentially expressed when comparing mid-day with mid-night, and mostly in red light. Gene expression profiles were largely unique in each color, although animals in blue and green were overall more similar to each other than to red light.ConclusionsTogether, these analyses support the hypothesis that cnidarians are sensitive to red light, and this perception results in a rich transcriptional and divergent behavioral response. Future work determining the specific molecular mechanisms driving the circadian and potential circatidal rhythms measured here would be impactful to connect gene expression variation with behavioral variation in this eyeless species.", "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-022-08426-7", "doi": "10.1186/s12864-022-08426-7", "title": "Taxonomic distribution and evolutionary analysis of the equol biosynthesis gene cluster", "publicationYear": 2022, "publicationDate": "2022-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "23", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Keith Dufault-Thompson, Brantley Hall, Xiaofang Jiang", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 21, "referenceCount": 68, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s12864-022-08426-7", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s12864-022-08426-7.pdf", "abstract": "Abstract Background Equol, an isoflavonoid metabolite with possible health benefits in humans, is known to be produced by some human gut bacteria. While the genes encoding the equol production pathway have been characterized in a few bacterial strains, a systematic analysis of the equol production pathway is currently lacking. Results This study presents an analysis of the taxonomic distribution and evolutionary history of the gene cluster encoding the equol production pathway. A survey for equol gene clusters within the Genome Taxonomy Database bacterial genomes and human gut metagenomes resulted in the identification of a highly conserved gene cluster found in nine bacterial species from the Eggerthellaceae family. The identified gene clusters from human gut metagenomes revealed potential variations in the equol gene cluster organization and gene content within the equol-producing Eggerthellaceae clades. Subsequent analysis showed that in addition to the four genes directly involved in equol production, multiple other genes were consistently found in the equol gene clusters. These genes were predicted to encode a putative electron transport complex and hydrogenase maturase system, suggesting potential roles for them in the equol production pathway. Analysis of the gene clusters and a phylogenetic reconstruction of a putative NAD kinase gene provided evidence of the recent transfer of the equol gene cluster from a basal Eggerthellaceae species to Slackia_A equolifaciens, Enteroscipio sp000270285, and Lactococcus garvieae 20–92. Conclusions This analysis demonstrates that the highly conserved equol gene cluster is taxonomically restricted to the Eggerthellaceae family of bacteria and provides evidence of the role of horizontal gene transfer in the evolutionary history of these genes. These results provide a foundation for future studies of equol production in the human gut and future efforts related to bioengineering and the use of equol-producing bacteria as probiotics.", "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.jgg.2020.04.006", "doi": "10.1016/j.jgg.2020.04.006", "title": "DNA methyltransferases in hematological malignancies", "publicationYear": 2020, "publicationDate": "2020-07", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Genetics and Genomics", "volume": "47", "issue": "7", "page": "361-372", "issn": "1673-8527", "isbn": null, "authors": "Nguyet-Minh Hoang, Lixin Rui", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 66, "referenceCount": 113, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.jgg.2020.04.006", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.xgen.2025.101138", "doi": "10.1016/j.xgen.2025.101138", "title": "Mapping disease loci to biological processes via joint pleiotropic and epigenomic partitioning", "publicationYear": 2026, "publicationDate": "2026-04", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Genomics", "volume": "6", "issue": "4", "page": "101138", "issn": "2666-979X", "isbn": null, "authors": "Gaspard Kerner, Nolan Kamitaki, Benjamin Strober, Alkes L. Price", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 95, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "NIH", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.xgen.2025.101138", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-021-07525-1", "doi": "10.1186/s12864-021-07525-1", "title": "Genotype-expression interactions for BDNF across human brain regions", "publicationYear": 2021, "publicationDate": "2021-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "22", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Patrick Devlin, Xueyuan Cao, Ansley Grimes Stanfill", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 23, "referenceCount": 64, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s12864-021-07525-1", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s12864-021-07525-1.pdf", "abstract": "AbstractBackgroundGenetic variations in brain-derived neurotrophic factor (BDNF) are associated with various psychiatric disorders including depression, obsessive-compulsive disorder, substance use disorders, and schizophrenia; altered gene expression triggered by these genetic variants may serve to create these phenotypes. But genotype-expression interactions for this gene have not been well-studied across brain regions relevant for psychiatric disorders.ResultsAt false discovery rate (FDR) of 10% (q &lt; 0.1), a total of 61 SNPs were associated withBDNFexpression in cerebellum (n = 209), 55 SNPs in cortex (n = 205), 48 SNPs in nucleus accumbens (n = 202), 47 SNPs in caudate (n = 194), and 58 SNPs in cerebellar hemisphere (n = 175). We identified a set of 30 SNPs in 2 haplotype blocks that were associated with alterations in expression for each of these 5 regions. The first haplotype block included variants associated in the literature with panic disorders (rs16917204), addiction (rs11030104), bipolar disorder (rs16917237/rs2049045), and obsessive-compulsive disorder (rs6265). Likewise, variants in the second haplotype block have been previously associated with disorders such as nicotine addiction, major depressive disorder (rs988748), and epilepsy (rs6484320/rs7103411).ConclusionsThis work supports the association of variants withinBDNFfor expression changes in these key brain regions that may contribute to common behavioral phenotypes for disorders of compulsion, impulsivity, and addiction. These SNPs should be further investigated as possible therapeutic and diagnostic targets to aid in management of these and other psychiatric disorders.", "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.gdata.2015.06.029", "doi": "10.1016/j.gdata.2015.06.029", "title": "Molecular subtyping of leiomyosarcoma with 3′ end RNA sequencing", "publicationYear": 2015, "publicationDate": "2015-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Genomics Data", "volume": "5", "issue": null, "page": "366-367", "issn": "2213-5960", "isbn": null, "authors": "Xiangqian Guo, Erna Forgó, Matt van de Rijn", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 11, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.gdata.2015.06.029", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.xhgg.2026.100564", "doi": "10.1016/j.xhgg.2026.100564", "title": "Evaluating genetic ancestry inference from single-cell transcriptomic datasets", "publicationYear": 2026, "publicationDate": "2026-04", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Human Genetics and Genomics Advances", "volume": "7", "issue": "2", "page": "100564", "issn": "2666-2477", "isbn": null, "authors": "Jianing Yao, Steven Gazal", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "NIH", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.xhgg.2026.100564", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-018-5171-2", "doi": "10.1186/s12864-018-5171-2", "title": "Comparative genomics analysis to differentiate metabolic and virulence gene potential in gastric versus enterohepatic Helicobacter species", "publicationYear": 2018, "publicationDate": "2018-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "19", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Anthony Mannion, Zeli Shen, James G. Fox", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 34, "referenceCount": 108, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Institutes of Health, National Institutes of Health, National Institutes of Health, National Institutes of Health", "funderIds": "10.13039/100000002, 10.13039/100000002, 10.13039/100000002, 10.13039/100000002", "url": "https://doi.org/10.1186/s12864-018-5171-2", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s12864-018-5171-2.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.ygeno.2015.09.004", "doi": "10.1016/j.ygeno.2015.09.004", "title": "The DNA methylation landscape of human melanoma", "publicationYear": 2015, "publicationDate": "2015-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Genomics", "volume": "106", "issue": "6", "page": "322-330", "issn": "0888-7543", "isbn": null, "authors": "Seung-Gi Jin, Wenying Xiong, Xiwei Wu, Lu Yang, Gerd P. Pfeifer", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 47, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "NIH, NIH", "funderIds": "10.13039/100000002, 10.13039/100000002", "url": "https://doi.org/10.1016/j.ygeno.2015.09.004", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1152/physiolgenomics.00241.2026", "doi": "10.1152/physiolgenomics.00241.2026", "title": "Understanding hypertensive renal injury: a well-structured approach", "publicationYear": 2026, "publicationDate": "2026-08-01", "type": "journal-article", "publisher": "American Physiological Society", "containerTitle": "Physiological Genomics", "volume": "58", "issue": "8", "page": "394-395", "issn": "1094-8341, 1531-2267", "isbn": null, "authors": "Peter A. Doris", "authorCount": 1, "firstAuthorAffiliation": "University of Texas Health Science Center at Houston", "isReferencedByCount": 0, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": null, "funderNames": "HHS | National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1152/physiolgenomics.00241.2026", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s40246-024-00655-z", "doi": "10.1186/s40246-024-00655-z", "title": "Rapid discrimination between deleterious and benign missense mutations in the CAGI 6 experiment", "publicationYear": 2024, "publicationDate": "2024-08-27", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Human Genomics", "volume": "18", "issue": "1", "page": null, "issn": "1479-7364", "isbn": null, "authors": "Eshel Faraggi, Robert L. Jernigan, Andrzej Kloczkowski", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 56, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": "National Institutes of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1186/s40246-024-00655-z", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s40246-024-00655-z.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s12864-018-4580-6", "doi": "10.1186/s12864-018-4580-6", "title": "Clustering multilayer omics data using MuNCut", "publicationYear": 2018, "publicationDate": "2018-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "BMC Genomics", "volume": "19", "issue": "1", "page": null, "issn": "1471-2164", "isbn": null, "authors": "Sebastian J. Teran Hidalgo, Shuangge Ma", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 13, "referenceCount": 39, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Institutes of Health, National Bureau of Statistics of China", "funderIds": "10.13039/100000002, 10.13039/100009376", "url": "https://doi.org/10.1186/s12864-018-4580-6", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s12864-018-4580-6.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.jgg.2016.04.003", "doi": "10.1016/j.jgg.2016.04.003", "title": "A repetitive DNA-directed program of chromosome packaging during mitosis", "publicationYear": 2016, "publicationDate": "2016-08", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Genetics and Genomics", "volume": "43", "issue": "8", "page": "471-476", "issn": "1673-8527", "isbn": null, "authors": "Shao-Jun Tang", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "NIH", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.jgg.2016.04.003", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s40246-015-0029-z", "doi": "10.1186/s40246-015-0029-z", "title": "Complement regulator CD46: genetic variants and disease associations", "publicationYear": 2015, "publicationDate": "2015-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Human Genomics", "volume": "9", "issue": "1", "page": null, "issn": "1479-7364", "isbn": null, "authors": "M. Kathryn Liszewski, John P. Atkinson", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 99, "referenceCount": 84, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": "National Institutes of Health, National Institutes of Health", "funderIds": "10.13039/100000002, 10.13039/100000002", "url": "https://doi.org/10.1186/s40246-015-0029-z", "pdfUrl": "http://link.springer.com/content/pdf/10.1186/s40246-015-0029-z.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1186/s40246-021-00326-3", "doi": "10.1186/s40246-021-00326-3", "title": "COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy", "publicationYear": 2021, "publicationDate": "2021-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Human Genomics", "volume": "15", "issue": "1", "page": null, "issn": "1479-7364", "isbn": null, "authors": "Giuseppe Novelli, Michela Biancolella, Ruty Mehrian-Shai, Vito Luigi Colona, Anderson F. Brito, Nathan D. Grubaugh, Vasilis Vasiliou, Lucio Luzzatto, Juergen K. V. Reichardt", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 43, "referenceCount": 119, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "National Institutes of Health, Fondazione Roma", "funderIds": "10.13039/100000002, 10.13039/501100015822", "url": "https://doi.org/10.1186/s40246-021-00326-3", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s40246-021-00326-3.pdf", "abstract": "AbstractCOVID-19 has engulfed the world and it will accompany us all for some time to come. Here, we review the current state at the milestone of 1 year into the pandemic, as declared by the WHO (World Health Organization). We review several aspects of the on-going pandemic, focusing first on two major topics: viral variants and the human genetic susceptibility to disease severity. We then consider recent and exciting new developments in therapeutics, such as monoclonal antibodies, and in prevention strategies, such as vaccines. We also briefly discuss how advances in basic science and in biotechnology, under the threat of a worldwide emergency, have accelerated to an unprecedented degree of the transition from the laboratory to clinical applications. While every day we acquire more and more tools to deal with the on-going pandemic, we are aware that the path will be arduous and it will require all of us being community-minded. In this respect, we lament past delays in timely full investigations, and we call for bypassing local politics in the interest of humankind on all continents.", "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
{"paperId": "10.1016/j.gdata.2016.12.006", "doi": "10.1016/j.gdata.2016.12.006", "title": "Gene expression profiling of U2AF2 dependent RNA-protein interactions during CD4 + T cell activation", "publicationYear": 2017, "publicationDate": "2017-03", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Genomics Data", "volume": "11", "issue": null, "page": "77-80", "issn": "2213-5960", "isbn": null, "authors": "Thomas C Whisenant", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 9, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Institute of Health", "funderIds": "10.13039/100000002", "url": "https://doi.org/10.1016/j.gdata.2016.12.006", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "YZoHRnnoz2dYBNoCb", "_dataset_id": "S7DQny1Pqi30eS3mQ"}
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{"paperId": "10.1371/journal.pone.0021509", "doi": "10.1371/journal.pone.0021509", "title": "Inferring the Population Expansions in Peopling of Japan", "publicationYear": 2011, "publicationDate": "2011-06-29", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "6", "issue": "6", "page": "e21509", "issn": "1932-6203", "isbn": null, "authors": "Min-Sheng Peng, Ya-Ping Zhang", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 66, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0021509", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0031622", "doi": "10.1371/journal.pone.0031622", "title": "Mechanisms Underlying Stage-1 TRPL Channel Translocation in Drosophila Photoreceptors", "publicationYear": 2012, "publicationDate": "2012-02-20", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "7", "issue": "2", "page": "e31622", "issn": "1932-6203", "isbn": null, "authors": "Minh-Ha Lieu, Maximiliano J. Vallejos, Emily Michael, Susan Tsunoda", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 8, "referenceCount": 47, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0031622", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0056714", "doi": "10.1371/journal.pone.0056714", "title": "Functional Pathway Analysis Using SCNP of FLT3 Receptor Pathway Deregulation in AML Provides Prognostic Information Independent from Mutational Status", "publicationYear": 2013, "publicationDate": "2013-02-19", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "8", "issue": "2", "page": "e56714", "issn": "1932-6203", "isbn": null, "authors": "Alessandra Cesano, Santosh Putta, David B. Rosen, Aileen C. Cohen, Urte Gayko, Kavita Mathi, John Woronicz, Rachael E. Hawtin, Larry Cripe, Zhuoxin Sun, Martin S. Tallman, Elisabeth Paietta", "authorCount": 12, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 55, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0056714", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0007978", "doi": "10.1371/journal.pone.0007978", "title": "A Genome-Wide Analysis of Array-Based Comparative Genomic Hybridization (CGH) Data to Detect Intra-Species Variations and Evolutionary Relationships", "publicationYear": 2009, "publicationDate": "2009-11-24", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "4", "issue": "11", "page": "e7978", "issn": "1932-6203", "isbn": null, "authors": "Apratim Mitra, George Liu, Jiuzhou Song", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 8, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0007978", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0088949", "doi": "10.1371/journal.pone.0088949", "title": "Snoring and Glaucoma", "publicationYear": 2014, "publicationDate": "2014-02-13", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "9", "issue": "2", "page": "e88949", "issn": "1932-6203", "isbn": null, "authors": "Ya Xing Wang, Liang Xu, Jian Jun Li, Hua Yang, Ya Qin Zhang, Jost B. Jonas", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0088949", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0029463", "doi": "10.1371/journal.pone.0029463", "title": "Neonatal Androgenization Exacerbates Alcohol-Induced Liver Injury in Adult Rats, an Effect Abrogated by Estrogen", "publicationYear": 2011, "publicationDate": "2011-12-20", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "6", "issue": "12", "page": "e29463", "issn": "1932-6203", "isbn": null, "authors": "Whitney M. Ellefson, Ashley M. Lakner, Alicia Hamilton, Iain H. McKillop, Herbert L. Bonkovsky, Nury M. Steuerwald, Yvette M. Huet, Laura W. Schrum", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0029463", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0118862", "doi": "10.1371/journal.pone.0118862", "title": "Analysis of IL-6, STAT3 and HSPA1L Gene Polymorphisms in Anti-Tuberculosis Drug-Induced Hepatitis in a Nested Case-Control Study", "publicationYear": 2015, "publicationDate": "2015-03-19", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLOS ONE", "volume": "10", "issue": "3", "page": "e0118862", "issn": "1932-6203", "isbn": null, "authors": "Jing Wang, Ru Chen, Shaowen Tang, Xiaozhen Lv, Shanshan Wu, Yuan Zhang, Yinyin Xia, Pei Gao, Dehua Tu, Dafang Chen, Siyan Zhan", "authorCount": 11, "firstAuthorAffiliation": null, "isReferencedByCount": 8, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0118862", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0070568", "doi": "10.1371/journal.pone.0070568", "title": "Combining Evidence of Preferential Gene-Tissue Relationships from Multiple Sources", "publicationYear": 2013, "publicationDate": "2013-08-12", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "8", "issue": "8", "page": "e70568", "issn": "1932-6203", "isbn": null, "authors": "Jing Guo, Mårten Hammar, Lisa Öberg, Shanmukha S. Padmanabhuni, Marcus Bjäreland, Daniel Dalevi", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0070568", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0317490", "doi": "10.1371/journal.pone.0317490", "title": "Inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults", "publicationYear": 2025, "publicationDate": "2025-03-13", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLOS ONE", "volume": "20", "issue": "3", "page": "e0317490", "issn": "1932-6203", "isbn": null, "authors": "Huakai Wang, Chao Zhang, Yuxin Sun, Sirui Sun, Zhe Wang, Honggang Xiang", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Natural Science Foundation of China, Technology Development Project of Pudong Science, Technology and Economic Commission of Shanghai, Outstanding Leaders Training Program of Pudong Health Commission of Shanghai", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.1371/journal.pone.0317490", "pdfUrl": null, "abstract": "Background The precise link between dietary consumption of n-3 and n-6 fatty acids and hyperuricemia remains equivocal. Accordingly, the purpose of the current investigation is to clarify any possible associations between the consumption of n-3 and n-6 fatty acids and hyperuricemia in the context of American adults. Materials and methods The present investigation employed a cross-sectional design, comprising a sample of 21,120 American adults above the age of 20 from the National Health and Nutrition Examination Survey (NHANES) waves between 2007 and 2016. The dietary consumption of n-3 and n-6 fatty acids was measured through two 24-h dietary recall interviews. To assess the relationships of dietary consumption of n3 and n6 fatty acids with hyperuricemia, we applied multivariable logistic regression, t tests, chi-square tests, and restricted cubic spline. To determine the robustness of our findings, sensitivity analyses were also carried out. Results The results of the multivariable logistic regression models indicated a significant correlation between dietary consumption of n3 and n6 fatty acids and hyperuricemia. The ORs with 95% CIs of hyperuricemia for the highest tertile versus lowest tertile of dietary consumption of n3 and n6 fatty acids were 0.76 (0.66, 0.88) (p &lt; 0.001) and 0.72 (0.64, 0.82) (p &lt; 0.001), respectively. Moreover, dose‒response analyses revealed a linear relationship between n-3 and n-6 fatty acid consumption and the risk of hyperuricemia. Conclusion The findings of this study indicate a significant inverse correlation between the dietary consumption of n3 and n6 fatty acids and hyperuricemia in the US adult population. Notably, there was no significant relationship between the n6:n3 ratio and hyperuricemia.", "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0017937", "doi": "10.1371/journal.pone.0017937", "title": "A Class Representative Model for Pure Parsimony Haplotyping under Uncertain Data", "publicationYear": 2011, "publicationDate": "2011-03-25", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "6", "issue": "3", "page": "e17937", "issn": "1932-6203", "isbn": null, "authors": "Daniele Catanzaro, Martine Labbé, Luciano Porretta", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0017937", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0311163", "doi": "10.1371/journal.pone.0311163", "title": "Scalable and rapid nearest neighbor particle search using adaptive disk sector", "publicationYear": 2025, "publicationDate": "2025-03-20", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLOS ONE", "volume": "20", "issue": "3", "page": "e0311163", "issn": "1932-6203", "isbn": null, "authors": "Jong-Hyun Kim, Jung Lee", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 55, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0311163", "pdfUrl": null, "abstract": "In this paper, we propose a framework for efficiently accelerating Nearest Neighbor Particle (NNP) calculations in a movable particle-based system by leveraging the dynamic changes in disk sectors. The NNP region based on particles and disk sectors is determined by the following three conditions: 1) The position of the disk resides within the range of neighbor particles. 2) The position of a neighbor particle exists within a disk sector. 3) A neighbor particle exists between the two vectors that form the disk sector. When all of these conditions are satisfied, we assume that there is a particle within the disk sector. In this paper, we automatically update the inspection range of NNP, which is the disk sector, based on the movement of particles. To calculate the dynamic changes in the disk sector, we control the direction, length, and angle of the disk based on the positions and velocities of particles. Ultimately, we accelerate the computation of NNP by utilizing the particles located within the calculated disk sector. The proposed acceleration method can be implemented simply, as it operates on the particles within the disk sector using closed-form expressions, without the explicit data structures like trees. Especially in the case of movable particles, unlike the conventional adaptive tree approach that requires continuous data structure updates, the proposed method can be efficiently utilized in applications requiring NNP. This is because it rapidly calculates collision areas using closed-form expressions that are adjusted according to the particles’ motion. Our method yielded results that were 2 to 20 times faster compared to Hash tables or K-d trees in experiments conducted across diverse scenes. Furthermore, its scalability was demonstrated through its application in various scenarios (particle-based fluids, splash and foam, isoline tracking, turbulent flow, collision handling).", "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0016109", "doi": "10.1371/journal.pone.0016109", "title": "A Simple Model for the Influence of Meiotic Conversion Tracts on GC Content", "publicationYear": 2011, "publicationDate": "2011-01-13", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "6", "issue": "1", "page": "e16109", "issn": "1932-6203", "isbn": null, "authors": "Marie-Claude Marsolier-Kergoat", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0016109", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0125548", "doi": "10.1371/journal.pone.0125548", "title": "Netrin-1 – DCC Signaling Systems and Age-Related Macular Degeneration", "publicationYear": 2015, "publicationDate": "2015-05-07", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLOS ONE", "volume": "10", "issue": "5", "page": "e0125548", "issn": "1932-6203", "isbn": null, "authors": "John Paul SanGiovanni, Jing Chen, Ankur S. Gupta, Lois E. H. Smith, Przemyslaw Sapieha, Phil H. Lee", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/publicdomain/zero/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0125548", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0147584", "doi": "10.1371/journal.pone.0147584", "title": "Extensive Field Survey, Laboratory and Greenhouse Studies Reveal Complex Nature of Pseudomonas syringae-Associated Hazelnut Decline in Central Italy", "publicationYear": 2016, "publicationDate": "2016-02-03", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLOS ONE", "volume": "11", "issue": "2", "page": "e0147584", "issn": "1932-6203", "isbn": null, "authors": "Jay Ram Lamichhane, Claudia Bartoli, Leonardo Varvaro", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0147584", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0100766", "doi": "10.1371/journal.pone.0100766", "title": "Effect of High-Frequency Stimulation of the Perforant Path on Previously Acquired Spatial Memory in Rats: Influence of Memory Strength and Reactivation", "publicationYear": 2014, "publicationDate": "2014-06-27", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "9", "issue": "6", "page": "e100766", "issn": "1932-6203", "isbn": null, "authors": "Katherine G. Akers, Derek A. Hamilton", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 17, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0100766", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0109244", "doi": "10.1371/journal.pone.0109244", "title": "The Effects of the Shape and Size of the Clinical Target Volume on the Planning Target Volume Margin", "publicationYear": 2014, "publicationDate": "2014-10-02", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "9", "issue": "10", "page": "e109244", "issn": "1932-6203", "isbn": null, "authors": "Buhong Zheng, Zhiyu Huang, Jinluan Li", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 13, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0109244", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0059253", "doi": "10.1371/journal.pone.0059253", "title": "Bovine Lactoferrin Decreases Cholera-Toxin-Induced Intestinal Fluid Accumulation in Mice by Ganglioside Interaction", "publicationYear": 2013, "publicationDate": "2013-04-08", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "8", "issue": "4", "page": "e59253", "issn": "1932-6203", "isbn": null, "authors": "Fulton P. Rivera, Anicia M. Medina, Sandra Bezada, Roberto Valencia, María Bernal, Rina Meza, Ryan C. Maves, Theresa J. Ochoa", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 35, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/publicdomain/zero/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0059253", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0045808", "doi": "10.1371/journal.pone.0045808", "title": "Presence of IgG Anti-gp160/120 Antibodies Confers Higher HIV Capture Capacity to Erythrocytes from HIV-Positive Individuals", "publicationYear": 2012, "publicationDate": "2012-09-25", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "7", "issue": "9", "page": "e45808", "issn": "1932-6203", "isbn": null, "authors": "Maria Noé Garcia, Maria Sol dos Ramos Farias, Lucia Fazzi, Daniel Grasso, Roberto Daniel Rabinovich, Maria Mercedes Ávila", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0045808", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0012318", "doi": "10.1371/journal.pone.0012318", "title": "Do Randomized Controlled Trials Discuss Healthcare Costs?", "publicationYear": 2010, "publicationDate": "2010-08-23", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "5", "issue": "8", "page": "e12318", "issn": "1932-6203", "isbn": null, "authors": "G. Michael Allan, Christina Korownyk, Kate LaSalle, Ben Vandermeer, Victoria Ma, Douglas Klein, Donna Manca", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0012318", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0112932", "doi": "10.1371/journal.pone.0112932", "title": "A Reconstruction Method Based on AL0FGD for Compressed Sensing in Border Monitoring WSN System", "publicationYear": 2014, "publicationDate": "2014-12-02", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "9", "issue": "12", "page": "e112932", "issn": "1932-6203", "isbn": null, "authors": "Yan Wang, Xi Wu, Wenzao Li, Yi Zhang, Zhi Li, Jiliu Zhou", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0112932", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0073083", "doi": "10.1371/journal.pone.0073083", "title": "Fabrication of Dense Non-Circular Nanomagnetic Device Arrays Using Self-Limiting Low-Energy Glow-Discharge Processing", "publicationYear": 2013, "publicationDate": "2013-08-14", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "8", "issue": "8", "page": "e73083", "issn": "1932-6203", "isbn": null, "authors": "Zhen Zheng, Long Chang, Ivan Nekrashevich, Paul Ruchhoeft, Sakhrat Khizroev, Dmitri Litvinov", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0073083", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0035156", "doi": "10.1371/journal.pone.0035156", "title": "Unique Profile of Ordered Arrangements of Repetitive Elements in the C57BL/6J Mouse Genome Implicating Their Functional Roles", "publicationYear": 2012, "publicationDate": "2012-04-18", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "7", "issue": "4", "page": "e35156", "issn": "1932-6203", "isbn": null, "authors": "Young-Kwan Lee, Kang-Hoon Lee, Seon-Gyu Kim, Ramzi Melhem, Chang-Suk Moon, Sicong Liu, David G. Greenhalgh, Kiho Cho", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0035156", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0122974", "doi": "10.1371/journal.pone.0122974", "title": "Perioperative Chemotherapy in Gastroesophageal Cancer. A Retrospective Monocenter Evaluation of 42 Cases", "publicationYear": 2015, "publicationDate": "2015-04-09", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLOS ONE", "volume": "10", "issue": "4", "page": "e0122974", "issn": "1932-6203", "isbn": null, "authors": "Ann-Christin E. Brehler, Wolfgang Hartmann, Stefanie Wiebe, Andrea Kerkhoff, Christoph Schliemann, Daniel Palmes, Norbert Senninger, Frank Lenze, Hansjoerg Ullerich, Wolfgang E. Berdel, Torsten Kessler", "authorCount": 11, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0122974", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0102890", "doi": "10.1371/journal.pone.0102890", "title": "An AUG Codon Conserved for Protein Function Rather than Translational Initiation: The Story of the Protein sElk1", "publicationYear": 2014, "publicationDate": "2014-07-18", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "9", "issue": "7", "page": "e102890", "issn": "1932-6203", "isbn": null, "authors": "Noemie Legrand, Tanguy Araud, Beatrice Conne, Odin Kuijpers, Pascale Jaquier-Gubler, Joseph Curran", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 18, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0102890", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0114819", "doi": "10.1371/journal.pone.0114819", "title": "Added Value of Arterial Enhancement Fraction Color Maps for the Characterization of Small Hepatic Low-Attenuating Lesions in Patients with Colorectal Cancer", "publicationYear": 2015, "publicationDate": "2015-02-23", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLOS ONE", "volume": "10", "issue": "2", "page": "e0114819", "issn": "1932-6203", "isbn": null, "authors": "Mina Park, Yong Eun Chung, Kyung Ah Kim, Woo-Suk Chung, Hye Sun Lee, Kyung Hwa Han, Myeong-Jin Kim, Ki Whang Kim", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0114819", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0127422", "doi": "10.1371/journal.pone.0127422", "title": "Translational Initiation at a Non-AUG Start Codon for Human and Mouse Negative Elongation Factor-B", "publicationYear": 2015, "publicationDate": "2015-05-26", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLOS ONE", "volume": "10", "issue": "5", "page": "e0127422", "issn": "1932-6203", "isbn": null, "authors": "Haihui Pan, Xiayan Zhao, Xiaowen Zhang, Mohamed Abouelsoud, Jianlong Sun, Craig April, Asma Amleh, Jian-Bing Fan, Yanfen Hu, Rong Li", "authorCount": 10, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0127422", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0102412", "doi": "10.1371/journal.pone.0102412", "title": "Strain Differences in Fitness of Escherichia coli O157:H7 to Resist Protozoan Predation and Survival in Soil", "publicationYear": 2014, "publicationDate": "2014-07-14", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "9", "issue": "7", "page": "e102412", "issn": "1932-6203", "isbn": null, "authors": "Subbarao V. Ravva, Chester Z. Sarreal, Robert E. Mandrell", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 10, "referenceCount": 36, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/publicdomain/zero/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0102412", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0072930", "doi": "10.1371/journal.pone.0072930", "title": "PML Nuclear Bodies and SATB1 Are Associated with HLA Class I Expression in EBV+ Hodgkin Lymphoma", "publicationYear": 2013, "publicationDate": "2013-08-29", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "8", "issue": "8", "page": "e72930", "issn": "1932-6203", "isbn": null, "authors": "Yuxuan Liu, Anke van den Berg, Rianne Veenstra, Bea Rutgers, Ilja Nolte, Gustaaf van Imhoff, Lydia Visser, Arjan Diepstra", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 31, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0072930", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0030053", "doi": "10.1371/journal.pone.0030053", "title": "Robust Metabolic Responses to Varied Carbon Sources in Natural and Laboratory Strains of Saccharomyces cerevisiae", "publicationYear": 2012, "publicationDate": "2012-01-09", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "7", "issue": "1", "page": "e30053", "issn": "1932-6203", "isbn": null, "authors": "Wayne A. Van Voorhies", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0030053", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0126927", "doi": "10.1371/journal.pone.0126927", "title": "Health Behaviors of Korean Gastric Cancer Survivors with Hypertension: A Propensity Analysis of KNHANES III-V (2005–2012)", "publicationYear": 2015, "publicationDate": "2015-05-22", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLOS ONE", "volume": "10", "issue": "5", "page": "e0126927", "issn": "1932-6203", "isbn": null, "authors": "So-Ra Jo, Ju-Youn Joh, Ju-Ri Jeong, Sun Kim, Yeon-Pyo Kim", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 39, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0126927", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0108888", "doi": "10.1371/journal.pone.0108888", "title": "Protein NMR Structures Refined without NOE Data", "publicationYear": 2014, "publicationDate": "2014-10-03", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "9", "issue": "10", "page": "e108888", "issn": "1932-6203", "isbn": null, "authors": "Hyojung Ryu, Tae-Rae Kim, SeonJoo Ahn, Sunyoung Ji, Jinhyuk Lee", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 47, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0108888", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0007049", "doi": "10.1371/journal.pone.0007049", "title": "Role of Polypyrimidine Tract Binding Protein in Mediating Internal Initiation of Translation of Interferon Regulatory Factor 2 RNA", "publicationYear": 2009, "publicationDate": "2009-09-16", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "4", "issue": "9", "page": "e7049", "issn": "1932-6203", "isbn": null, "authors": "Debojyoti Dhar, Musturi Venkataramana, Anand Ponnuswamy, Saumitra Das", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0007049", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0037737", "doi": "10.1371/journal.pone.0037737", "title": "Predicting Inter-Species Cross-Talk in Two-Component Signalling Systems", "publicationYear": 2012, "publicationDate": "2012-05-22", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "7", "issue": "5", "page": "e37737", "issn": "1932-6203", "isbn": null, "authors": "Sonja Pawelczyk, Kathryn A. Scott, Rebecca Hamer, Gareth Blades, Charlotte M. Deane, George H. Wadhams", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 48, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0037737", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0027120", "doi": "10.1371/journal.pone.0027120", "title": "Comparative Transcriptional Analysis Reveals Differential Gene Expression between Asymmetric and Symmetric Zygotic Divisions in Tobacco", "publicationYear": 2011, "publicationDate": "2011-11-01", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLoS ONE", "volume": "6", "issue": "11", "page": "e27120", "issn": "1932-6203", "isbn": null, "authors": "Tian-Xiang Hu, Miao Yu, Jie Zhao", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0027120", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1371/journal.pone.0129908", "doi": "10.1371/journal.pone.0129908", "title": "Luminance, Colour, Viewpoint and Border Enhanced Disparity Energy Model", "publicationYear": 2015, "publicationDate": "2015-06-24", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLOS ONE", "volume": "10", "issue": "6", "page": "e0129908", "issn": "1932-6203", "isbn": null, "authors": "Jaime A. Martins, João M. F. Rodrigues, Hans du Buf", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 10, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1371/journal.pone.0129908", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "206PhaEiRnhJ08yqt", "_dataset_id": "f3y8fLlzTFllkCUfU"}
{"paperId": "10.1109/lcsys.2026.3704086", "doi": "10.1109/lcsys.2026.3704086", "title": "Spectral Distance Between Graphs and the Energy-Based Controllability of Networks", "publicationYear": 2026, "publicationDate": "2026", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Control Systems Letters", "volume": "10", "issue": null, "page": "997-1002", "issn": "2475-1456", "isbn": null, "authors": "Muhammad Usama Zubair, Waseem Abbas", "authorCount": 2, "firstAuthorAffiliation": "Department of Electrical Engineering, The University of Texas at Dallas, Richardson, TX, USA", "isReferencedByCount": 0, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1109/lcsys.2026.3704086", "pdfUrl": "https://ieeexplore.ieee.org/ielam/7782633/11370312/11569008-aam.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1002/j.1537-2197.1973.tb06000.x", "doi": "10.1002/j.1537-2197.1973.tb06000.x", "title": "ALTITUDINAL VARIATION IN HAWAIIAN METROSIDEROS", "publicationYear": 1973, "publicationDate": "1973-11", "type": "journal-article", "publisher": "Wiley", "containerTitle": "American Journal of Botany", "volume": "60", "issue": "10", "page": "991-1002", "issn": "0002-9122, 1537-2197", "isbn": null, "authors": "Carolyn A. Corn, William M. Hiesey", "authorCount": 2, "firstAuthorAffiliation": "Department of Botany University of Hawaii  Honolulu", "isReferencedByCount": 34, "referenceCount": 17, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1002/j.1537-2197.1973.tb06000.x", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fj.1537-2197.1973.tb06000.x", "abstract": "Hawaiian Metrosideros is a highly polymorphic complex that is distributed throughout the six major islands of the Hawaiian Island chain from tropical climates near sea level to altitudes up to 8,500 ft with frost. Its populations extend continuously over many areas with average annual precipitation ranging from 30 to 450 in. and with diverse edaphic and topographical features. The Hawaiian forms are probably all derived from one or a very small number of ancestral introductions that arrived within the last 20 million years by longdistance dispersal. Seeds collected from diverse altitudinal sites on the islands of Hawaii and Maui and grown under uniform greenhouse conditions at Honolulu show evidence of ecotypic differentiation along altitudinal gradients. Seedlings from these islands separated by 50 miles of ocean show parallelism in their altitudinal differentiation in plant height and leaf size, but with strongly overlapping variation from site to site.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.3390/ma16206812", "doi": "10.3390/ma16206812", "title": "Role of CdTe Interface Structure on CdS/CdTe Photovoltaic Device Performance", "publicationYear": 2023, "publicationDate": "2023-10-23", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Materials", "volume": "16", "issue": "20", "page": "6812", "issn": "1996-1944", "isbn": null, "authors": "Niva K. Jayswal, Dipendra Adhikari, Indra Subedi, Ambalanath Shan, Nikolas J. Podraza", "authorCount": 5, "firstAuthorAffiliation": "Department of Physics and Astronomy, Wright Center for Photovoltaics Innovation and Commercialization, The University of Toledo, Toledo, OH 43606, USA", "isReferencedByCount": 4, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Science Foundation (NSF), National Science Foundation (NSF), Air Force Research Laboratory, Air Force Research Laboratory", "funderIds": "10.13039/100000001, 10.13039/100000001, 10.13039/100006602, 10.13039/100006602", "url": "https://doi.org/10.3390/ma16206812", "pdfUrl": null, "abstract": "Glancing angle deposition (GLAD) of CdTe can produce a cubic, hexagonal, or mixed phase crystal structure depending upon the oblique deposition angles (Φ) and substrate temperature. GLAD CdTe films are prepared at different Φ at room temperature (RT) and a high temperature (HT) of 250 °C and used as interlayers between the n-type hexagonal CdS window layer and the p-type cubic CdTe absorber layer to investigate the role of interfacial tailoring at the CdS/CdTe heterojunction in photovoltaic (PV) device performance. The Φ = 80° RT GLAD CdTe interlayer and CdS both have the hexagonal structure, which reduces lattice mismatch at the CdS/CdTe interface and improves electronic quality at the heterojunction for device performance optimization. The device performance of HT CdS/CdTe solar cells with Φ = 80° RT with 50 to 350 nm thick GLAD CdTe interlayers is evaluated in which a 250 nm interlayer device shows the best device performance with a 0.53 V increase in open-circuit voltage and fill-factor product and a 0.73% increase in absolute efficiency compared to the HT baseline PV device without an interlayer.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1016/j.jmaa.2015.08.029", "doi": "10.1016/j.jmaa.2015.08.029", "title": "Derivatives of compound matrix valued functions", "publicationYear": 2016, "publicationDate": "2016-01", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Mathematical Analysis and Applications", "volume": "433", "issue": "2", "page": "1459-1485", "issn": "0022-247X", "isbn": null, "authors": "Brendan P.W. Ames, Hristo S. Sendov", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Science Foundation, Office of Naval Research, National Science Foundation, Office of Naval Research", "funderIds": "10.13039/100000001, 10.13039/100000006, 10.13039/100000001, 10.13039/100000006", "url": "https://doi.org/10.1016/j.jmaa.2015.08.029", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1002/jrs.4662", "doi": "10.1002/jrs.4662", "title": "Investigating the firing protocol of Athenian pottery production: A Raman study of replicate and ancient sherds", "publicationYear": 2015, "publicationDate": "2015-10", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Journal of Raman Spectroscopy", "volume": "46", "issue": "10", "page": "996-1002", "issn": "0377-0486, 1097-4555", "isbn": null, "authors": "Ilaria Cianchetta, Jeff Maish, David Saunders, Marc Walton, Apurva Mehta, Brendan Foran, Karen Trentelman", "authorCount": 7, "firstAuthorAffiliation": "Getty Conservation Institute  Los Angeles CA USA", "isReferencedByCount": 20, "referenceCount": 31, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1002/jrs.4662", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjrs.4662", "abstract": "The black and red coloration of ancient Athenian pottery is due to the different oxidation states of iron oxide: reduced Fe2+ (black) and oxidized Fe3+ (red). It has long been thought that a single, three‐step firing — oxidation–reduction–oxidation — was used to manipulate the Fe valence state and achieve different degrees of vitrification between the slip and the body to produce the high contrast black and red images. However, complex and layered structures, with slips of different color overlaying each other, are sometimes found, raising the question of the adequacy of a single three‐step firing to produce complex architectures. The firing conditions used in the production of an ancient vessel in the collection of the J. Paul Getty Museum, in which a red glossy layer is found between the black gloss and the body, were investigated. The ancient specimen was compared to a set of replicates produced and fired under a series of controlled temperatures and oxygen fugacities. Raman spectroscopy was used to identify the mineralogical phases present in both the ancient and the replicate samples, and the shape and position of the Eg mode in hematite provided a measure of the temperatures at which the minerals were formed. The results suggest the ancient vessel was produced using at least two separate firings: a high temperature firing under oxidizing conditions to create the underlying red glossy layer, followed by a three‐step firing to create the surface black gloss decoration. This finding suggests the firing of ancient Athenian pottery was more complex than previously thought. Copyright © 2015 John Wiley &amp; Sons, Ltd.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1109/tbcas.2016.2614845", "doi": "10.1109/tbcas.2016.2614845", "title": "A Bidirectional Neural Interface IC With Chopper Stabilized BioADC Array and Charge Balanced Stimulator", "publicationYear": 2016, "publicationDate": "2016-10", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Biomedical Circuits and Systems", "volume": "10", "issue": "5", "page": "990-1002", "issn": "1932-4545, 1940-9990", "isbn": null, "authors": "Elliot Greenwald, Ernest So, Qihong Wang, Mohsen Mollazadeh, Christoph Maier, Ralph Etienne-Cummings, Gert Cauwenberghs, Nitish Thakor", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 46, "referenceCount": 37, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": "NIH, NSF, NIH", "funderIds": "10.13039/100000002, 10.13039/100000001, 10.13039/100000002", "url": "https://doi.org/10.1109/tbcas.2016.2614845", "pdfUrl": "http://ieeexplore.ieee.org/ielaam/4156126/7776995/7738450-aam.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1109/ccnc51644.2023.10060248", "doi": "10.1109/ccnc51644.2023.10060248", "title": "Performance Evaluation of Vehicular Wireless Communications in Terahertz Bands", "publicationYear": 2023, "publicationDate": "2023-01-08", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2023 IEEE 20th Consumer Communications &amp; Networking Conference (CCNC)", "volume": null, "issue": null, "page": "1001-1002", "issn": null, "isbn": null, "authors": "Salomon Satche, Danda B. Rawat", "authorCount": 2, "firstAuthorAffiliation": "Howard University,Dept of Electrical Engineering and Computer Science,Washington DC,USA", "isReferencedByCount": 0, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": "U.S. NSF", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1109/ccnc51644.2023.10060248", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1177/0278364920918919", "doi": "10.1177/0278364920918919", "title": "Reactive sampling-based path planning with temporal logic specifications", "publicationYear": 2020, "publicationDate": "2020-07", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "The International Journal of Robotics Research", "volume": "39", "issue": "8", "page": "1002-1028", "issn": "0278-3649, 1741-3176", "isbn": null, "authors": "Cristian Ioan Vasile, Xiao Li, Calin Belta", "authorCount": 3, "firstAuthorAffiliation": "Laboratory for Information and Decision Systems,Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA", "isReferencedByCount": 49, "referenceCount": 71, "isOpenAccess": true, "licenseUrl": "http://www.sagepub.com/licence-information-for-chorus", "funderNames": "National Science Foundation, National Science Foundation, Office of Naval Research, Office of Naval Research", "funderIds": "10.13039/100000001, 10.13039/100000001, 10.13039/100000006, 10.13039/100000006", "url": "https://doi.org/10.1177/0278364920918919", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/0278364920918919", "abstract": "We develop a sampling-based motion planning algorithm that combines long-term temporal logic goals with short-term reactive requirements. The mission specification has two parts: (1) a global specification given as a linear temporal logic (LTL) formula over a set of static service requests that occur at the regions of a known environment, and (2) a local specification that requires servicing a set of dynamic requests that can be sensed locally during the execution. The proposed computational framework consists of two main ingredients: (a) an off-line sampling-based algorithm for the construction of a global transition system that contains a path satisfying the LTL formula; and (b) an on-line sampling-based algorithm to generate paths that service the local requests, while making sure that the satisfaction of the global specification is not affected. The off-line algorithm has four main features. First, it is incremental, in the sense that the procedure for finding a satisfying path at each iteration scales only with the number of new samples generated at that iteration. Second, the underlying graph is sparse, which implies low complexity for the overall method. Third, it is probabilistically complete. Fourth, under some mild assumptions, it has the best possible complexity bound. The on-line algorithm leverages ideas from LTL monitoring and potential functions to ensure progress towards the satisfaction of the global specification while servicing locally sensed requests. Examples and experimental trials illustrating the usefulness and the performance of the framework are included.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1109/icra48891.2023.10161280", "doi": "10.1109/icra48891.2023.10161280", "title": "MPC with Sensor-Based Online Cost Adaptation", "publicationYear": 2023, "publicationDate": "2023-05-29", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2023 IEEE International Conference on Robotics and Automation (ICRA)", "volume": null, "issue": null, "page": "996-1002", "issn": null, "isbn": null, "authors": "Avadesh Meduri, Huaijiang Zhu, Armand Jordana, Ludovic Righetti", "authorCount": 4, "firstAuthorAffiliation": "Tandon School of Engineering, New York University,USA", "isReferencedByCount": 3, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1109/icra48891.2023.10161280", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1109/sp46214.2022.9833595", "doi": "10.1109/sp46214.2022.9833595", "title": "Time-Print: Authenticating USB Flash Drives with Novel Timing Fingerprints", "publicationYear": 2022, "publicationDate": "2022-05", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2022 IEEE Symposium on Security and Privacy (SP)", "volume": null, "issue": null, "page": "1002-1017", "issn": null, "isbn": null, "authors": "Patrick Cronin, Xing Gao, Haining Wang, Chase Cotton", "authorCount": 4, "firstAuthorAffiliation": "University of Delaware", "isReferencedByCount": 14, "referenceCount": 68, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-009", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1109/sp46214.2022.9833595", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1111/jace.13643", "doi": "10.1111/jace.13643", "title": "Low‐Temperature Control of Twins and Abnormal Grain Growth in BaTiO <sub>3</sub>", "publicationYear": 2015, "publicationDate": "2015-08", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Journal of the American Ceramic Society", "volume": "98", "issue": "8", "page": "2381-2387", "issn": "0002-7820, 1551-2916", "isbn": null, "authors": "David T. Harris, Matthew J. Burch, Jing Li, Elizabeth C. Dickey, Jon‐Paul Maria", "authorCount": 5, "firstAuthorAffiliation": "Department of Materials Science and Engineering North Carolina State University Raleigh North Carolina 27606", "isReferencedByCount": 6, "referenceCount": 37, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": "National Science Foundation, National Science Foundation, Defense MicroElectronics Activity", "funderIds": "10.13039/100000001, 10.13039/100000001", "url": "https://doi.org/10.1111/jace.13643", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/jace.13643", "abstract": "The microstructure of polycrystalline barium titanate (BaTiO 3 ) thin films processed with a liquid‐phase can be controlled by the crystallographic orientation of the underlying sapphire substrate. During postdeposition crystallization, the tendency for {111} twin nucleation, which drives subsequent abnormal grain growth, depends upon the specific sapphire facet. Specifically, tilting away from the close‐packed c‐ plane modifies the orientation, morphology, and relative amount of an interfacial BaAl 2 O 4 second phase. These factors control the density of twin formation, and thus overall grain size of the crystallized BaTiO 3 . As the substrate orientation transitions from c ‐plane, to r ‐plane, to a ‐plane, the twin density is reduced, the average grain size decreases systematically from 270 to 130 nm, and the grain structure becomes overall more homogeneous. This twinning mechanism and abnormal grain growth occur by 900°C, several hundred degrees lower than reported previously.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1109/acait63902.2024.11022193", "doi": "10.1109/acait63902.2024.11022193", "title": "Intelligent Building Fire Evacuation Indication System Based on Edge Computing Devices", "publicationYear": 2024, "publicationDate": "2024-11-08", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2024 8th Asian Conference on Artificial Intelligence Technology (ACAIT)", "volume": null, "issue": null, "page": "1002-1007", "issn": null, "isbn": null, "authors": "Pei Wang, Jiaming Liu, Ya Peng, Hui Zhang", "authorCount": 4, "firstAuthorAffiliation": "Tsinghua University,Institute of Public Safety Research,Beijing,China", "isReferencedByCount": 2, "referenceCount": 12, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1109/acait63902.2024.11022193", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1007/s11858-016-0806-8", "doi": "10.1007/s11858-016-0806-8", "title": "Assessing early number learning in play", "publicationYear": 2016, "publicationDate": "2016-11", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "ZDM", "volume": "48", "issue": "7", "page": "991-1002", "issn": "1863-9690, 1863-9704", "isbn": null, "authors": "Anita A. Wager, Amy Noelle Parks", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 17, "referenceCount": 49, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": "National Science Foundation, National Science Foundation", "funderIds": "10.13039/100000001, 10.13039/100000001", "url": "https://doi.org/10.1007/s11858-016-0806-8", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s11858-016-0806-8.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1109/focs46700.2020.00097", "doi": "10.1109/focs46700.2020.00097", "title": "Resolution of the Burrows-Wheeler Transform Conjecture", "publicationYear": 2020, "publicationDate": "2020-11", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2020 IEEE 61st Annual Symposium on Foundations of Computer Science (FOCS)", "volume": null, "issue": null, "page": "1002-1013", "issn": null, "isbn": null, "authors": "Dominik Kempa, Tomasz Kociumaka", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 27, "referenceCount": 67, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": "NSF, ISF, BSF, ERC, EU", "funderIds": "10.13039/100000001, 10.13039/501100003977, 10.13039/100001005, 10.13039/100010663, 10.13039/501100000780", "url": "https://doi.org/10.1109/focs46700.2020.00097", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1137/17m1118907", "doi": "10.1137/17m1118907", "title": "Enumerating Projections of Integer Points in Unbounded Polyhedra", "publicationYear": 2018, "publicationDate": "2018-01", "type": "journal-article", "publisher": "Society for Industrial & Applied Mathematics (SIAM)", "containerTitle": "SIAM Journal on Discrete Mathematics", "volume": "32", "issue": "2", "page": "986-1002", "issn": "0895-4801, 1095-7146", "isbn": null, "authors": "Danny Nguyen, Igor Pak", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": null, "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1137/17m1118907", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1080/10511482.2022.2055614", "doi": "10.1080/10511482.2022.2055614", "title": "Interrupting Inequality Through Community Land Trusts", "publicationYear": 2023, "publicationDate": "2023-07-04", "type": "journal-article", "publisher": "Informa UK Limited", "containerTitle": "Housing Policy Debate", "volume": "33", "issue": "4", "page": "1002-1026", "issn": "1051-1482, 2152-050X", "isbn": null, "authors": "Jakob Kendall Schneider, Mary Clare Lennon, Susan Saegert", "authorCount": 3, "firstAuthorAffiliation": "The Graduate Center, CUNY, New York, USA", "isReferencedByCount": 12, "referenceCount": 144, "isOpenAccess": true, "licenseUrl": null, "funderNames": "National Science Foundation [, ]", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1080/10511482.2022.2055614", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1017/jfm.2024.1154", "doi": "10.1017/jfm.2024.1154", "title": "Moment of momentum integral analysis of turbulent boundary layers with pressure gradient", "publicationYear": 2025, "publicationDate": "2025-01-10", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Journal of Fluid Mechanics", "volume": "1002", "issue": null, "page": null, "issn": "0022-1120, 1469-7645", "isbn": null, "authors": "Armin Kianfar, Perry L. Johnson", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 61, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1017/jfm.2024.1154", "pdfUrl": null, "abstract": "Turbulent boundary layers on immersed objects can be significantly altered by the pressure gradients imposed by the flow outside the boundary layer. The interaction of turbulence and pressure gradients can lead to complex phenomena such as relaminarization, history effects and flow separation. The angular momentum integral (AMI) equation (Elnahhas &amp; Johnson, J. Fluid Mech., vol. 940, 2022, A36) is extended and applied to high-fidelity simulation datasets of non-zero pressure gradient turbulent boundary layers. The AMI equation provides an exact mathematical equation for quantifying how turbulence, free-stream pressure gradients and other effects alter the skin friction coefficient relative to a baseline laminar boundary layer solution. The datasets explored include flat-plate boundary layers with nearly constant adverse pressure gradients, a boundary layer over the suction surface of a two-dimensional NACA 4412 airfoil and flow over a two-dimensional Gaussian bump. Application of the AMI equation to these datasets maps out the similarities and differences in how boundary layers interact with favourable and adverse pressure gradients in various scenarios. Further, the fractional contribution of the pressure gradient to skin friction attenuation in adverse-pressure-gradient boundary layers appears in the AMI equation as a new Clauser-like parameter with some advantages for understanding similarities and differences related to upstream history effects. The results highlight the applicability of the integral-based analysis to provide quantitative, interpretable assessments of complex boundary layer physics.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1016/j.pt.2021.06.001", "doi": "10.1016/j.pt.2021.06.001", "title": "Nematode infection and antinematode immunity in Drosophila", "publicationYear": 2021, "publicationDate": "2021-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Trends in Parasitology", "volume": "37", "issue": "11", "page": "1002-1013", "issn": "1471-4922", "isbn": null, "authors": "Yaprak Ozakman, Ioannis Eleftherianos", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 18, "referenceCount": 102, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "George Washington University, National Science Foundation, National Institutes of Health", "funderIds": "10.13039/100007108, 10.13039/100000001, 10.13039/100000002", "url": "https://doi.org/10.1016/j.pt.2021.06.001", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1007/s10468-017-9754-4", "doi": "10.1007/s10468-017-9754-4", "title": "A Tannakian Interpretation of the Elliptic Infinitesimal Braid Lie Algebras", "publicationYear": 2018, "publicationDate": "2018-10", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Algebras and Representation Theory", "volume": "21", "issue": "5", "page": "943-1002", "issn": "1386-923X, 1572-9079", "isbn": null, "authors": "Benjamin Enriquez, Pavel Etingof", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1007/s10468-017-9754-4", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s10468-017-9754-4.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1016/j.adt.2011.09.004", "doi": "10.1016/j.adt.2011.09.004", "title": "Discovery of gallium, germanium, lutetium, and hafnium isotopes", "publicationYear": 2012, "publicationDate": "2012-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Atomic Data and Nuclear Data Tables", "volume": "98", "issue": "5", "page": "983-1002", "issn": "0092-640X", "isbn": null, "authors": "J.L. Gross, M. Thoennessen", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 11, "referenceCount": 146, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1016/j.adt.2011.09.004", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1021/acsmacrolett.1c00305", "doi": "10.1021/acsmacrolett.1c00305", "title": "Relationship between Ionic Conductivity, Glass Transition Temperature, and Dielectric Constant in Poly(vinyl ether) Lithium Electrolytes", "publicationYear": 2021, "publicationDate": "2021-08-17", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "ACS Macro Letters", "volume": "10", "issue": "8", "page": "1002-1007", "issn": "2161-1653, 2161-1653", "isbn": null, "authors": "Jennifer Imbrogno, Kazuya Maruyama, Frederick Rivers, Jacob R. Baltzegar, Zidan Zhang, Paul W. Meyer, Venkat Ganesan, Sadahito Aoshima, Nathaniel A. Lynd", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 40, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": "Welch Foundation, Welch Foundation, Division of Chemical, Bioengineering, Environmental, and Transport Systems, National Science Foundation", "funderIds": "10.13039/100000928, 10.13039/100000928, 10.13039/100000146, 10.13039/100000001", "url": "https://doi.org/10.1021/acsmacrolett.1c00305", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1111/psj.12227", "doi": "10.1111/psj.12227", "title": "Participation and Political Influence in Complex Governance Systems", "publicationYear": 2019, "publicationDate": "2019-11", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Policy Studies Journal", "volume": "47", "issue": "4", "page": "1002-1025", "issn": "0190-292X, 1541-0072", "isbn": null, "authors": "Jack Mewhirter, Eric A. Coleman, Ramiro Berardo", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 32, "referenceCount": 39, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#am", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1111/psj.12227", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpsj.12227", "abstract": "Public policy generally emerges from interactions among actors embedded within complex governance systems, composed of multiple actors and forums (issue‐based arenas where stakeholders repeatedly interact to resolve collective action problems). Such systems allow actors multiple forums wherein they can influence policy decisions. But actors do not value the decisions made in each forum equally, and it remains unclear how actors allocate resources across forums. This article links actor strategy to their influence within the forums the actors identify as most important (their primary forum). There is theoretical ambiguity about how actors invest their limited resources across the forums that affect their interests to maximize primary forum influence. Do they concentrate all their effort within the primary forum or participate more broadly? To answer this question, we offer two competing theories. First, broad participation may allow actors to develop political capital necessary to influence other actors and thus influence primary forum policies. The second approach notes the opportunity costs of broad participation—actors have fewer resources to invest in their primary forum. An analysis of stakeholder participation in the Sacramento–San Joaquin River Delta and Tampa Bay Watershed governance systems demonstrates that broader participation is associated with greater primary forum influence.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1021/ci400647u", "doi": "10.1021/ci400647u", "title": "Context-Based Features Enhance Protein Secondary Structure Prediction Accuracy", "publicationYear": 2014, "publicationDate": "2014-03-24", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of Chemical Information and Modeling", "volume": "54", "issue": "3", "page": "992-1002", "issn": "1549-9596, 1549-960X", "isbn": null, "authors": "Ashraf Yaseen, Yaohang Li", "authorCount": 2, "firstAuthorAffiliation": "Department of Computer Science, Old Dominion University, Norfolk, Virginia 23529, United States", "isReferencedByCount": 52, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": null, "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1021/ci400647u", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1090/proc/14772", "doi": "10.1090/proc/14772", "title": "𝖥𝖨-hyperhomology and ordered configuration spaces", "publicationYear": 2019, "publicationDate": "2019-09-20", "type": "journal-article", "publisher": "American Mathematical Society (AMS)", "containerTitle": "Proceedings of the American Mathematical Society", "volume": "148", "issue": "3", "page": "993-1002", "issn": "1088-6826, 0002-9939", "isbn": null, "authors": "Jeremy Miller, Jennifer Wilson", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 19, "isOpenAccess": true, "licenseUrl": "https://www.ams.org/publications/copyright-and-permissions", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1090/proc/14772", "pdfUrl": "https://www.ams.org/proc/2020-148-03/S0002-9939-2019-14772-9/proc14772_AM.pdf", "abstract": "Using a result of Gan–Li on F I \\mathsf {FI} -hyperhomology and a semisimplicial resolution of configuration spaces due to Randal-Williams, we establish an improved representation stability stable range for configuration spaces of distinct ordered points in a manifold. Our bounds on generation degree improve the best known stability slope by a factor of 5/2 in the most general case. We adapt this result of Gan–Li to apply beyond stability arguments involving highly connected simplicial complexes, and our methods suggest that their result may be widely applicable to improving most stability ranges for F I \\mathsf {FI} -modules in the current representation stability literature.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1112/topo.12077", "doi": "10.1112/topo.12077", "title": "Definition of cylindrical contact homology in dimension three", "publicationYear": 2018, "publicationDate": "2018-12", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Journal of Topology", "volume": "11", "issue": "4", "page": "1002-1053", "issn": "1753-8416, 1753-8424", "isbn": null, "authors": "Erkao Bao, Ko Honda", "authorCount": 2, "firstAuthorAffiliation": "Department of Mathematics University of California, Los Angeles Los Angeles CA 90095 USA", "isReferencedByCount": 12, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#am", "funderNames": "National Science Foundation, National Science Foundation", "funderIds": "10.13039/100000001, 10.13039/100000001", "url": "https://doi.org/10.1112/topo.12077", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1112%2Ftopo.12077", "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1002/elps.201600206", "doi": "10.1002/elps.201600206", "title": "A microfluidic paper‐based device to assess acetylcholinesterase activity", "publicationYear": 2017, "publicationDate": "2017-04", "type": "journal-article", "publisher": "Wiley", "containerTitle": "ELECTROPHORESIS", "volume": "38", "issue": "7", "page": "1002-1006", "issn": "0173-0835, 1522-2683", "isbn": null, "authors": "Chunye Liu, Frank A. Gomez", "authorCount": 2, "firstAuthorAffiliation": "Department of Chemistry and Biochemistry California State University  Los Angeles CA USA", "isReferencedByCount": 19, "referenceCount": 40, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#am", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1002/elps.201600206", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Felps.201600206", "abstract": "Neurotransmitters play key roles in cell‐to‐cell communication. These chemical messengers are involved in many functional processes, including growth, reproduction, memory, and behavior. In this communication, we describe a novel microfluidic paper‐based analytical device (μPAD) to detect acetylcholinesterase (AChE) activity and inhibitor screening through a colorimetric analysis. The μPAD is easily fabricated via a wax printing process whereby wax is deposited onto the surface of chromatographic paper, and heated to create a hydrophobic barrier. Separate solutions of 5,5′‐dithiobis‐(2‐nitrobenzoic acid) (DTNB) and samples containing AChE and acetylthiocholine iodide (ATC) (or cysteine, Cys), respectively, are directly spotted onto the μPAD. DTNB and AChE/ATC (or Cys) flow towards each other where a reaction occurs to form the yellow colored 2‐nitro‐5‐thiobenzoic acid anion (TNB2−). The device is dried, scanned, and analyzed yielding a linear range of average inverse yellow intensities versus substrate concentration. An IC50 value (0.045 nM) with a known inhibitor, neostigmine bromide (NB), is obtained on the device. μPADs are low cost and easy to fabricate and have great potential to quantify neurotransmitter activity.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1007/s00267-018-1002-0", "doi": "10.1007/s00267-018-1002-0", "title": "Forward-looking farmers owning multiple potential wetland restoration sites: implications for efficient restoration", "publicationYear": 2018, "publicationDate": "2018-04", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Environmental Management", "volume": "61", "issue": "4", "page": "577-596", "issn": "0364-152X, 1432-1009", "isbn": null, "authors": "Svetlana Schroder (Kushch), Zhengxin Lang, Sergey Rabotyagov", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 79, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1007/s00267-018-1002-0", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s00267-018-1002-0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1093/imaiai/iax011", "doi": "10.1093/imaiai/iax011", "title": "Universality laws for randomized dimension reduction, with applications", "publicationYear": 2018, "publicationDate": "2018-09-19", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Information and Inference: A Journal of the IMA", "volume": "7", "issue": "3", "page": "337-446", "issn": "2049-8764, 2049-8772", "isbn": null, "authors": "Samet Oymak, Joel A Tropp", "authorCount": 2, "firstAuthorAffiliation": "The Simons Institute for the Theory of Computing, Melvin Calvin Laboratory, Berkeley, CA, USA", "isReferencedByCount": 47, "referenceCount": 88, "isOpenAccess": true, "licenseUrl": "https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model", "funderNames": "NSF, ONR", "funderIds": "10.13039/100000001, 10.13039/100000006", "url": "https://doi.org/10.1093/imaiai/iax011", "pdfUrl": "http://academic.oup.com/imaiai/article-pdf/7/3/337/32468280/iax011.pdf", "abstract": "AbstractDimension reduction is the process of embedding high-dimensional data into a lower dimensional space to facilitate its analysis. In the Euclidean setting, one fundamental technique for dimension reduction is to apply a random linear map to the data. This dimension reduction procedure succeeds when it preserves certain geometric features of the set. The question is how large the embedding dimension must be to ensure that randomized dimension reduction succeeds with high probability. This article studies a natural family of randomized dimension reduction maps and a large class of data sets. It proves that there is a phase transition in the success probability of the dimension reduction map as the embedding dimension increases. For a given data set, the location of the phase transition is the same for all maps in this family. Furthermore, each map has the same stability properties, as quantified through the minimum RSV. These results can be viewed as new universality laws in high-dimensional stochastic geometry. Universality laws for randomized dimension reduction have many applications in applied mathematics, signal processing and statistics. They yield design principles for numerical linear algebra algorithms, for compressed sensing measurement ensembles and for random linear codes. Furthermore, these results have implications for the performance of statistical estimation methods under a large class of random experimental designs.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1109/tgcn.2018.2869039", "doi": "10.1109/tgcn.2018.2869039", "title": "Dual-Battery Enabled Profit Driven User Association in Green Heterogeneous Cellular Networks", "publicationYear": 2018, "publicationDate": "2018-12", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Green Communications and Networking", "volume": "2", "issue": "4", "page": "1002-1011", "issn": "2473-2400", "isbn": null, "authors": "Xilong Liu, Nirwan Ansari", "authorCount": 2, "firstAuthorAffiliation": "Helen &#x0026; John C. Hartmann Department of Electrical and Computer Engineering, Advanced Networking Laboratory, New Jersey Institute of Technology, Newark, NJ, USA", "isReferencedByCount": 16, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1109/tgcn.2018.2869039", "pdfUrl": "https://ieeexplore.ieee.org/ielam/7511293/8538882/8456544-aam.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1145/2024724.2024945", "doi": "10.1145/2024724.2024945", "title": "Decoupling for power gating", "publicationYear": 2011, "publicationDate": "2011-06-05", "type": "proceedings-article", "publisher": "ACM", "containerTitle": "Proceedings of the 48th Design Automation Conference", "volume": null, "issue": null, "page": "1002-1007", "issn": null, "isbn": null, "authors": "Tong Xu, Peng Li, Boyuan Yan", "authorCount": 3, "firstAuthorAffiliation": "Texas A&amp;M University, College Station, Texas", "isReferencedByCount": 13, "referenceCount": 9, "isOpenAccess": true, "licenseUrl": "https://www.acm.org/publications/policies/copyright_policy#Background", "funderNames": "National Science Foundation, Semiconductor Research Corporation", "funderIds": "10.13039/100000001, 10.13039/100000028", "url": "https://doi.org/10.1145/2024724.2024945", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1145/3242587.3242660", "doi": "10.1145/3242587.3242660", "title": "Ply", "publicationYear": 2018, "publicationDate": "2018-10-11", "type": "proceedings-article", "publisher": "ACM", "containerTitle": "Proceedings of the 31st Annual ACM Symposium on User Interface Software and Technology", "volume": null, "issue": null, "page": "991-1002", "issn": null, "isbn": null, "authors": "Sarah Lim, Joshua Hibschman, Haoqi Zhang, Eleanor O'Rourke", "authorCount": 4, "firstAuthorAffiliation": "Northwestern University, Evanston, IL, USA", "isReferencedByCount": 12, "referenceCount": 35, "isOpenAccess": true, "licenseUrl": "https://www.acm.org/publications/policies/copyright_policy#Background", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1145/3242587.3242660", "pdfUrl": "https://dl.acm.org/doi/pdf/10.1145/3242587.3242660", "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1002/we.2336", "doi": "10.1002/we.2336", "title": "Evaluation of log‐of‐power extremum seeking control for wind turbines using large eddy simulations", "publicationYear": 2019, "publicationDate": "2019-07", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Wind Energy", "volume": "22", "issue": "7", "page": "992-1002", "issn": "1095-4244, 1099-1824", "isbn": null, "authors": "Umberto Ciri, Stefano Leonardi, Mario A. Rotea", "authorCount": 3, "firstAuthorAffiliation": "Department of Mechanical Engineering The University of Texas at Dallas  Richardson Texas 75080‐3021 TX USA", "isReferencedByCount": 22, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#am", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1002/we.2336", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/we.2336", "abstract": "AbstractThe extremum seeking control (ESC) algorithm has been proposed to determine operating parameters that maximize power production below rated wind speeds (region II). This is usually done by measuring the turbine's power signal to determine optimal values for parameters of the control law or actuator settings. This paper shows that the standard ESC with power feedback is quite sensitive to variations in mean wind speed, with long convergence time at low wind speeds and aggressive transient response, possibly unstable, at high wind speeds. The paper also evaluates the performance, as measured by the dynamic and steady state response, of the ESC with feedback of the logarithm of the power signal (LP‐ESC). Large eddy simulations (LES) demonstrate that the LP‐ESC, calibrated at a given wind speed, exhibits consistent robust performance at all wind speeds in a typical region II. The LP‐ESC is able to achieve the optimal set‐point within a prescribed settling time, despite variations in the mean wind speed, turbulence, and shear. The LES have been conducted using realistic wind input profiles with shear and turbulence. The ESC and LP‐ESC are implemented in the LES without assuming the availability of analytical gradients.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1039/d3cb00084b", "doi": "10.1039/d3cb00084b", "title": "Bringing enzymes to the proximity party", "publicationYear": 2023, "publicationDate": "2023", "type": "journal-article", "publisher": "Royal Society of Chemistry (RSC)", "containerTitle": "RSC Chemical Biology", "volume": "4", "issue": "12", "page": "986-1002", "issn": "2633-0679", "isbn": null, "authors": "Gabrielle S. Tender, Carolyn R. Bertozzi", "authorCount": 2, "firstAuthorAffiliation": "Stanford University, Department of Chemistry and Sarafan ChEM-H, Stanford, CA 94305, USA", "isReferencedByCount": 15, "referenceCount": 117, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/3.0/", "funderNames": "National Institutes of Health, National Institutes of Health, Hertz Foundation, National Science Foundation, Stanford University", "funderIds": "10.13039/100000002, 10.13039/100000002, 10.13039/100005883, 10.13039/100000001, 10.13039/100005492", "url": "https://doi.org/10.1039/d3cb00084b", "pdfUrl": "http://pubs.rsc.org/en/content/articlepdf/2023/CB/D3CB00084B", "abstract": "Targeted enzymes can drive cell type-selective reactions that are not yet possible with other therapeutic approaches.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1109/eiecs59936.2023.10435426", "doi": "10.1109/eiecs59936.2023.10435426", "title": "Deep Learning Model Based on TCN-LSTM for Projectile Initial Velocity Inversion of High-spin Projectiles", "publicationYear": 2023, "publicationDate": "2023-09-22", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2023 3rd International Conference on Electronic Information Engineering and Computer Science (EIECS)", "volume": null, "issue": null, "page": "1002-1008", "issn": null, "isbn": null, "authors": "Hongyu Gao, Liangming Wang, Jian Fu, Yifan Yang", "authorCount": 4, "firstAuthorAffiliation": "Nanjing University of Science and Technology,Energy and Power Engineering", "isReferencedByCount": 0, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1109/eiecs59936.2023.10435426", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1002/j.1537-2197.1964.tb06730.x", "doi": "10.1002/j.1537-2197.1964.tb06730.x", "title": "THE CHEMICAL REGULATION OF THE DORMANCY PHASES OF BUD DEVELOPMENT", "publicationYear": 1964, "publicationDate": "1964-10", "type": "journal-article", "publisher": "Wiley", "containerTitle": "American Journal of Botany", "volume": "51", "issue": "9", "page": "1002-1012", "issn": "0002-9122, 1537-2197", "isbn": null, "authors": "Harry Smith, N. P. Kefford", "authorCount": 2, "firstAuthorAffiliation": "Department of Biology Josiah Willard Gibbs Laboratories, Yale University  New Haven Connecticut", "isReferencedByCount": 43, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1002/j.1537-2197.1964.tb06730.x", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fj.1537-2197.1964.tb06730.x", "abstract": "literature pertaining to the development and regulation of dormancy in the buds of woody species is reviewed and interpreted as follows. Morphological observations, the effects of environmental factors, and other evidence support the concept that bud dormancy involves a cycle of 3 separate phases of development. Beginning at the developmental pattern of spring, the 3 phases are: (1) dormancy development leading to the dormant state; (2) release from dormancy leading to the non‐dormant state; and (3) the initiation of spring burst leading again to spring development. The regulation of dormancy is, therefore, discussed in terms of the regulation of development of the apex within each phase and the regulation of transitions between phases. The principal existing theory of dormancy regulation implies that dormancy consists, in total, of merely the inhibition of spring development, and that regulation involves first the accumulation of an inhibitor then its disappearance. The conceptual basis of this inhibitor theory is argued to be inadequate as is the experimental evidence for the existence of a specific inhibitor and for a correlation between its concentration and dormancy induction or release. There is little direct evidence on the mechanism of the regulation of bud development within any developmental phase. Circumstantial evidence suggests the developmental patterns arise from chemical patterns resulting from the interactions of classes of growth regulator such as auxin, kinin, and gibberellin. Some evidence exists concerning the regulation of the transitions between the phases of dormancy. A substance has recently been detected which may be a hormone regulating the initiation of dormancy development. The production of this substance may be photoperiodically determined. A role for gibberellins in the regulation of dormancy release has been postulated.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1007/s10589-016-9871-8", "doi": "10.1007/s10589-016-9871-8", "title": "Decomposable norm minimization with proximal-gradient homotopy algorithm", "publicationYear": 2017, "publicationDate": "2017-03", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Computational Optimization and Applications", "volume": "66", "issue": "2", "page": "345-381", "issn": "0926-6003, 1573-2894", "isbn": null, "authors": "Reza Eghbali, Maryam Fazel", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": "National Science Foundation, Office of Naval Research", "funderIds": "10.13039/100000001, 10.13039/100000006", "url": "https://doi.org/10.1007/s10589-016-9871-8", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s10589-016-9871-8.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1109/tifs.2019.2931068", "doi": "10.1109/tifs.2019.2931068", "title": "DP-ADMM: ADMM-Based Distributed Learning With Differential Privacy", "publicationYear": 2020, "publicationDate": "2020", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Information Forensics and Security", "volume": "15", "issue": null, "page": "1002-1012", "issn": "1556-6013, 1556-6021", "isbn": null, "authors": "Zonghao Huang, Rui Hu, Yuanxiong Guo, Eric Chan-Tin, Yanmin Gong", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 188, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1109/tifs.2019.2931068", "pdfUrl": "https://ieeexplore.ieee.org/ielam/10206/8833568/8772211-aam.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1111/jeb.13496", "doi": "10.1111/jeb.13496", "title": "Little to no inbreeding depression in a tapeworm with mixed mating", "publicationYear": 2019, "publicationDate": "2019-09", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Journal of Evolutionary Biology", "volume": "32", "issue": "9", "page": "1002-1010", "issn": "1010-061X, 1420-9101", "isbn": null, "authors": "Isabel C. Caballero, Charles D. Criscione", "authorCount": 2, "firstAuthorAffiliation": "Department of Wildlife and Fisheries Sciences Texas A&amp;M University College Station Texas USA", "isReferencedByCount": 4, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#am", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1111/jeb.13496", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/jeb.13496", "abstract": "AbstractMeta‐studies on hermaphrodites have found a negative relationship between primary selfing rates and levels of inbreeding depression (ID) and, thus, generally support purging in inbred systems. However, in plants, high among‐taxa variance in ID results in no difference in the mean ID between outcrossing and mixed‐mating taxa. Selective interference likely explains high ID among mixed‐mating taxa, whereas low levels of ID among mixed‐mating taxa are not as stressed. Among animal hermaphrodites, primarily molluscs, there are little data on mixed‐mating systems. To fill a taxonomic and mating system gap, we tested for ID in a mixed‐mating tapeworm, Oochoristica javaensis. We provide a direct estimate of ID across infection of an intermediate host by comparing selfing rates at two life history stages. We found little to no evidence for ID, and the level of ID falls in line with what is reported for highly selfing species even though O. javaensis has mixed mating. We discuss this result within the context of kin mating in O. javaensis. Our results emphasize that primary selfing rates alone may be insufficient to classify the inbreeding history in all species when testing for a relationship to ID. Mixed‐mating taxa, and possibly some outcrossing taxa, may exhibit low levels of ID if biparental inbreeding is also driving purging. We advocate that ID studies report estimates of inbreeding history (e.g. FIS or identity disequilibrium) from nature‐derived adult samples to provide context rather than relying on primary selfing rates alone.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1080/17476933.2016.1258066", "doi": "10.1080/17476933.2016.1258066", "title": "Narrow region principle and Liouville type results for fractional Lane–Emden system", "publicationYear": 2017, "publicationDate": "2017-07-03", "type": "journal-article", "publisher": "Informa UK Limited", "containerTitle": "Complex Variables and Elliptic Equations", "volume": "62", "issue": "7", "page": "1002-1014", "issn": "1747-6933, 1747-6941", "isbn": null, "authors": "Miaomiao Cai, Linfeng Mei", "authorCount": 2, "firstAuthorAffiliation": "School of Mathematics and Information Science, Henan Normal University, Xinxiang, China.", "isReferencedByCount": 3, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": null, "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1080/17476933.2016.1258066", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1080/08912963.2025.2516584", "doi": "10.1080/08912963.2025.2516584", "title": "A morphological character matrix describing shells from extant and extinct lucinid bivalves of the Western Atlantic", "publicationYear": 2026, "publicationDate": "2026-04-03", "type": "journal-article", "publisher": "Informa UK Limited", "containerTitle": "Historical Biology", "volume": "38", "issue": "4", "page": "1002-1011", "issn": "0891-2963, 1029-2381", "isbn": null, "authors": "Brooke L. Long-Fox", "authorCount": 1, "firstAuthorAffiliation": "MorphoBank, Phoenix Bioinformatics", "isReferencedByCount": 1, "referenceCount": 59, "isOpenAccess": true, "licenseUrl": null, "funderNames": "U.S. National Science Foundation, Palaeontological Research Institution", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1080/08912963.2025.2516584", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1016/j.tibtech.2024.02.002", "doi": "10.1016/j.tibtech.2024.02.002", "title": "Cryptographic approaches to authenticating synthetic DNA sequences", "publicationYear": 2024, "publicationDate": "2024-08", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Trends in Biotechnology", "volume": "42", "issue": "8", "page": "1002-1016", "issn": "0167-7799", "isbn": null, "authors": "Casey-Tyler Berezin, Samuel Peccoud, Diptendu M. Kar, Jean Peccoud", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 23, "referenceCount": 86, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Science Foundation, National Institutes of Health, NIGMS", "funderIds": "10.13039/100000001, 10.13039/100000002, 10.13039/100000057", "url": "https://doi.org/10.1016/j.tibtech.2024.02.002", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.3732/ajb.1200616", "doi": "10.3732/ajb.1200616", "title": "Interactions of hybridization and mating systems: A case study in <i>Leptosiphon</i> (Polemoniaceae)", "publicationYear": 2013, "publicationDate": "2013-06", "type": "journal-article", "publisher": "Wiley", "containerTitle": "American Journal of Botany", "volume": "100", "issue": "6", "page": "1002-1013", "issn": "0002-9122, 1537-2197", "isbn": null, "authors": "Carol Goodwillie, Jennifer M. Ness", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 34, "referenceCount": 85, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.3732/ajb.1200616", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.3732%2Fajb.1200616", "abstract": "• Premise of the study: The roles of hybridization and mating systems in the evolution of angiosperms have been well studied, but less work has focused on their interactions. Self‐incompatible and self‐compatible species often show asymmetry in heterospecific pollen rejection. Self‐fertilization can preempt ovules before opportunities for hybridization. In turn, hybridization might affect mating system evolution through selection for selfing to avoid production of low fitness hybrids.• Methods: AFLP and morphological analyses were used to test for hybrids in a contact zone between species with contrasting breeding systems. Crossing experiments examined the relative contributions to reproductive isolation of pollen–pistil interactions, timing of self‐fertilization, and F1 viability and fertility. A diallel cross of siblings tested for an association between heterospecific incompatibility and S‐genotype in the self‐incompatible species.• Key results: A low frequency of hybrids was detected in the contact zone. Pollen–pistil interactions were partially consistent with the SI × SC rule; some individuals of the self‐incompatible species rejected heterospecific pollen, whereas the self‐compatible species was fully receptive to it. In the selfing species, individuals with early selfing produced fewer hybrid progeny than did those with delayed self‐compatibility when heterospecific pollen was applied after self‐pollen. Viability of F1s was high but fertility was low. Variability in heterospecific pollen rejection was not related to S‐genotype.• Conclusions: Both self‐fertilization and self‐incompatibility are associated with limits to hybridization at this site. The strong effect of timing of selfing on production of low fitness F1s suggests that hybridization might select for early selfing in this population.", "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1016/j.optmat.2014.01.010", "doi": "10.1016/j.optmat.2014.01.010", "title": "Optoelectronic properties of three dimensional WO3 nanoshale and its application for UV sensing", "publicationYear": 2014, "publicationDate": "2014-03", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Optical Materials", "volume": "36", "issue": "5", "page": "1002-1005", "issn": "0925-3467", "isbn": null, "authors": "Dali Shao, Mingpeng Yu, Jie Lian, Shayla Sawyer", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 43, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Science Foundation, National Science Foundation", "funderIds": "10.13039/100000001, 10.13039/100000001", "url": "https://doi.org/10.1016/j.optmat.2014.01.010", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1016/j.pnsc.2016.08.005", "doi": "10.1016/j.pnsc.2016.08.005", "title": "Plasmonic coupling in single flower-like gold nanoparticle assemblies", "publicationYear": 2016, "publicationDate": "2016-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Progress in Natural Science: Materials International", "volume": "26", "issue": "5", "page": "449-454", "issn": "1002-0071", "isbn": null, "authors": "Yi Luo, Lacie Dube, Yadong Zhou, Shengli Zou, Jing Zhao", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 8, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1016/j.pnsc.2016.08.005", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1103/physrevmaterials.4.113403", "doi": "10.1103/physrevmaterials.4.113403", "title": "Mechanism of stacking fault formation in metal(100) heteroepitaxial growth", "publicationYear": 2020, "publicationDate": "2020-11-16", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Physical Review Materials", "volume": "4", "issue": "11", "page": null, "issn": "2475-9953", "isbn": null, "authors": "Indiras Khatri, Ehsan H. Sabbar, Yunsic Shim, Jacques G. Amar", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "https://link.aps.org/licenses/aps-default-license", "funderNames": "National Science Foundation, Air Force Research Laboratory", "funderIds": "10.13039/100000001, 10.13039/100006602", "url": "https://doi.org/10.1103/physrevmaterials.4.113403", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1109/icuas65942.2025.11007822", "doi": "10.1109/icuas65942.2025.11007822", "title": "Co-Regulated Hierarchical Reinforcement Learning for Uncrewed Aircraft System Swarms", "publicationYear": 2025, "publicationDate": "2025-05-14", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2025 International Conference on Unmanned Aircraft Systems (ICUAS)", "volume": null, "issue": null, "page": "1002-1010", "issn": null, "isbn": null, "authors": "Grant Phillips, Jemin George, Justin Bradley", "authorCount": 3, "firstAuthorAffiliation": "School of Computing at the University of Nebraska-Lincoln,Lincoln,NE", "isReferencedByCount": 0, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-029", "funderNames": "National Science Foundation", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1109/icuas65942.2025.11007822", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1007/s10530-018-1819-8", "doi": "10.1007/s10530-018-1819-8", "title": "Stronger predation in a subtropical community dampens an invasive species-induced trophic cascade", "publicationYear": 2019, "publicationDate": "2019-01", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Biological Invasions", "volume": "21", "issue": "1", "page": "203-215", "issn": "1387-3547, 1573-1464", "isbn": null, "authors": "Katherine J. Papacostas, Amy L. Freestone", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 12, "referenceCount": 79, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": "Marine Station at Fort Pierce, National Science Foundation", "funderIds": "10.13039/100009189, 10.13039/100000001", "url": "https://doi.org/10.1007/s10530-018-1819-8", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s10530-018-1819-8.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1016/j.jelechem.2025.119744", "doi": "10.1016/j.jelechem.2025.119744", "title": "Peroxidase-mimicking Ce–hemin–MOFs/GO composite for enzyme-free electrochemical detection of H2O2", "publicationYear": 2026, "publicationDate": "2026-02", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Electroanalytical Chemistry", "volume": "1002", "issue": null, "page": "119744", "issn": "1572-6657", "isbn": null, "authors": "Hamidreza Ghaedamini, Riwaj Khanal, Dong-Shik Kim", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 84, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Science Foundation, National Science Foundation", "funderIds": "10.13039/100000001, 10.13039/100000001", "url": "https://doi.org/10.1016/j.jelechem.2025.119744", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1016/j.jde.2018.07.067", "doi": "10.1016/j.jde.2018.07.067", "title": "Time periodic and almost time periodic solutions to rotating stratified fluids subject to large forces", "publicationYear": 2019, "publicationDate": "2019-01", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Differential Equations", "volume": "266", "issue": "2-3", "page": "977-1002", "issn": "0022-0396", "isbn": null, "authors": "Matthias Hieber, Alex Mahalov, Ryo Takada", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 11, "referenceCount": 36, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "JSPS, NSF, JSPS", "funderIds": "10.13039/501100001691, 10.13039/100000001, 10.13039/501100001691", "url": "https://doi.org/10.1016/j.jde.2018.07.067", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.1109/tpwrd.2013.2291576", "doi": "10.1109/tpwrd.2013.2291576", "title": "Adaptive PI Control of STATCOM for Voltage Regulation", "publicationYear": 2014, "publicationDate": "2014-06", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Power Delivery", "volume": "29", "issue": "3", "page": "1002-1011", "issn": "0885-8977, 1937-4208", "isbn": null, "authors": "Yao Xu, Fangxing Li", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 108, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": "Stanford University¿Global Climate and Energy Project (GCEP), the National Science Foundation (NSF), DOE", "funderIds": "10.13039/100000001", "url": "https://doi.org/10.1109/tpwrd.2013.2291576", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "tL3GWgnFlxJ7g51JG", "_dataset_id": "p1ZGRRR03PQePN75v"}
{"paperId": "10.3390/s25195962", "doi": "10.3390/s25195962", "title": "Exploring the Effects of Acute Digital Sports Dance Intervention on Children’s Gross Motor Development, Executive Function, and Muscle Coordination Using Electromyography Sensors: A Randomized Repeated-Measures Study", "publicationYear": 2025, "publicationDate": "2025-09-25", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "19", "page": "5962", "issn": "1424-8220", "isbn": null, "authors": "Jiao He, Junya Zhao, Haojie Li, Jiangang Chen, Ying Qin", "authorCount": 5, "firstAuthorAffiliation": "School of Art, Wuhan Sports University, Wuhan 430079, China", "isReferencedByCount": 0, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s25195962", "pdfUrl": null, "abstract": "Objective: This paper examines how rhythm-enhanced digital dance affects children’s motor abilities, cognitive performance, and neuromuscular synchronization. Methods: In a randomized repeated-measures study, 38 children (7–12 years) underwent three conditions: groove music-accompanied dance (GODA), conventional music dance (CODA), and non-musical physical activity (CON). Assessments of gross motor skills (using TGMD-3), executive function (using BRIEF and Stroop Test), and muscle coordination (using sEMG) were conducted. Results: Gross motor skills: GODA showed significantly higher TGMD scores in locomotor (p = 0.03) and ball skills (p = 0.02) compared to both CODA and CON (p &lt; 0.001). Executive function: Inhibition and shifting dimensions showed significant post-intervention condition differences (p &lt; 0.05). Muscle coordination: GODA exhibited greater β- and γ-band COH areas in the standing long jump compared to both CODA (p = 0.02) and CON (p &lt; 0.001), and increased γ-band COH areas in single-leg balance compared to CODA (p = 0.02) and CON (p &lt; 0.001). Conclusions: Combining rhythmic auditory stimulation with movement training offers a promising approach for integrated motor-cognitive development in children.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25196166", "doi": "10.3390/s25196166", "title": "Frequency-Stable Low-Threshold SBS-OEO for Precision Temperature Sensing in Electromagnetically Harsh Environments", "publicationYear": 2025, "publicationDate": "2025-10-05", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "19", "page": "6166", "issn": "1424-8220", "isbn": null, "authors": "Yichao Teng, Mingyuan Yang, Li Han, Jixuan Wang, Guanbo Liu", "authorCount": 5, "firstAuthorAffiliation": "College of Meteorology and Oceanography, National University of Defense Technology, Changsha 410073, China", "isReferencedByCount": 0, "referenceCount": 28, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Natural Science Foundation of Hunan Province", "funderIds": "10.13039/501100004735", "url": "https://doi.org/10.3390/s25196166", "pdfUrl": null, "abstract": "In this research, precision temperature sensing for electromagnetically harsh environments was achieved utilizing a low-threshold frequency-stable optoelectronic oscillator (OEO) leveraging stimulated Brillouin scattering (SBS). The sensing mechanism relied on the temperature-dependent frequency shift in the SBS-induced notch filter. By embedding this filter in the OEO feedback loop, the oscillator’s output frequency was locked to the difference between the optical carrier frequency and the SBS notch center frequency. The temperature variations were translated into microwave frequency shifts through OEO oscillation, which was quantified with heterodyne detection. To suppress environmental perturbations, a Faraday rotation mirror (FRM) was integrated at the fiber end, creating a dual-pass SBS interaction that simultaneously enhanced the vibration immunity and reduced the SBS power threshold by 2.7 dB. The experimental results demonstrated a sensitivity of 1.0609 MHz/°C (R2 = 0.999) and a long-term stability of ±0.004 °C. This innovative scheme demonstrated significant advantages over conventional SBS-OEO temperature sensing approaches, particularly in terms of threshold reduction and environmental stability enhancement.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s23115258", "doi": "10.3390/s23115258", "title": "On the Virtualization of Audio Transducers", "publicationYear": 2023, "publicationDate": "2023-06-01", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "23", "issue": "11", "page": "5258", "issn": "1424-8220", "isbn": null, "authors": "Riccardo Giampiccolo, Alberto Bernardini, Oliviero Massi, Augusto Sarti", "authorCount": 4, "firstAuthorAffiliation": "Dipartimento di Elettronica, Informazione e Bioingegneria (DEIB), Politecnico di Milano, Piazza L. Da Vinci 32, 20133 Milano, Italy", "isReferencedByCount": 8, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s23115258", "pdfUrl": null, "abstract": "In audio transduction applications, virtualization can be defined as the task of digitally altering the acoustic behavior of an audio sensor or actuator with the aim of mimicking that of a target transducer. Recently, a digital signal preprocessing method for the virtualization of loudspeakers based on inverse equivalent circuit modeling has been proposed. The method applies Leuciuc’s inversion theorem to obtain the inverse circuital model of the physical actuator, which is then exploited to impose a target behavior through the so called Direct–Inverse–Direct Chain. The inverse model is designed by properly augmenting the direct model with a theoretical two-port circuit element called nullor. Drawing on this promising results, in this manuscript, we aim at describing the virtualization task in a broader sense, including both actuator and sensor virtualizations. We provide ready-to-use schemes and block diagrams which apply to all the possible combinations of input and output variables. We then analyze and formalize different versions of the Direct–Inverse–Direct Chain describing how the method changes when applied to sensors and actuators. Finally, we provide examples of applications considering the virtualization of a capacitive microphone and a nonlinear compression driver.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s21216964", "doi": "10.3390/s21216964", "title": "Biomimetic Chaotic Sensor for Moderate Static Magnetic Field", "publicationYear": 2021, "publicationDate": "2021-10-20", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "21", "issue": "21", "page": "6964", "issn": "1424-8220", "isbn": null, "authors": "Wojciech Korneta, Iacyel Gomes, Rodrigo Picos, Michal Zábovský", "authorCount": 4, "firstAuthorAffiliation": "University Science Park, University of Zilina, Univerzitna 8215/1, SK-01026 Zilina, Slovakia", "isReferencedByCount": 4, "referenceCount": 22, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Regional Development Fund, Ministry of Transport and Construction of the Slovak Republik", "funderIds": "10.13039/501100008530", "url": "https://doi.org/10.3390/s21216964", "pdfUrl": null, "abstract": "The effects of a static magnetic field on systems with chaotic dynamical behavior have attracted little attention so far. Here, Chua’s electronic circuit with an inductor placed in a static uniform magnetic field operating in a chaotic double-scroll regime is studied experimentally. The effect of the magnetic field on the duty cycle factor and the spike count rate, with spikes defined by crossings between the scrolls of the double-scroll attractor, is described. A slow monotonic variation in the duty cycle factor and constant spike count rate is observed for magnetic field intensities up to the threshold, where both these metrics change severely; the dynamic trajectory remains on one scroll and spikes disappear. The dependence of the static magnetic field intensity on Chua’s circuit resistivity at the threshold is given. Two biomimetic magnetic chaotic sensors are proposed: one based on one Chua’s circuit and another that can have various transfer functions and is composed of several independent Chua’s circuits.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s8128224", "doi": "10.3390/s8128224", "title": "A Modified Subpulse SAR Processing Procedure Based on the Range-Doppler Algorithm for Synthetic Wideband Waveforms", "publicationYear": 2008, "publicationDate": "2008-12-11", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "8", "issue": "12", "page": "8224-8236", "issn": "1424-8220", "isbn": null, "authors": "Byoung-Gyun Lim, Jea-Choon Woo, Hee-Young Lee, Young-Soo Kim", "authorCount": 4, "firstAuthorAffiliation": "1-Division of Electrical and Computer Engineering, Pohang University of Science and Technology, Pohang, Gyungbuk, 790-784, South Korea", "isReferencedByCount": 10, "referenceCount": 13, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/3.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s8128224", "pdfUrl": null, "abstract": "Synthetic wideband waveforms (SWW) combine a stepped frequency CW waveform and a chirp signal waveform to achieve high range resolution without requiring a large bandwidth or the consequent very high sampling rate. If an efficient algorithm like the range-Doppler algorithm (RDA) is used to acquire the SAR images for synthetic wideband signals, errors occur due to approximations, so the images may not show the best possible result. This paper proposes a modified subpulse SAR processing algorithm for synthetic wideband signals which is based on RDA. An experiment with an automobile-based SAR system showed that the proposed algorithm is quite accurate with a considerable improvement in resolution and quality of the obtained SAR image.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s150716105", "doi": "10.3390/s150716105", "title": "SNR Wall Effect Alleviation by Generalized Detector Employed in Cognitive Radio Networks", "publicationYear": 2015, "publicationDate": "2015-07-03", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "15", "issue": "7", "page": "16105-16135", "issn": "1424-8220", "isbn": null, "authors": "Modar Shbat, Vyacheslav Tuzlukov", "authorCount": 2, "firstAuthorAffiliation": "School of Electronics Engineering, College of IT Engineering, Kyungpook National University,  1370 Sankyuk-dong, Buk-gu, Daegu 702-701, Korea", "isReferencedByCount": 18, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s150716105", "pdfUrl": null, "abstract": "The most commonly used spectrum sensing techniques in cognitive radio (CR) networks, such as the energy detector (ED), matched filter (MF), and others, suffer from the noise uncertainty and signal-to-noise ratio (SNR) wall phenomenon. These detectors cannot achieve the required signal detection performance regardless of the sensing time. In this paper, we explore a signal processing scheme, namely, the generalized detector (GD) constructed based on the generalized approach to signal processing (GASP) in noise, in spectrum sensing of CR network based on antenna array with the purpose to alleviate the SNR wall problem and improve the signal detection robustness under the low SNR. The simulation results confirm our theoretical issues and effectiveness of GD implementation in CR networks based on antenna array.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s22062204", "doi": "10.3390/s22062204", "title": "Joint Semi-Blind Self-Interference Cancellation and Equalisation Processes in 5G QC-LDPC-Encoded Short-Packet Full-Duplex Transmissions", "publicationYear": 2022, "publicationDate": "2022-03-11", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "22", "issue": "6", "page": "2204", "issn": "1424-8220", "isbn": null, "authors": "Bao Quoc Vuong, Roland Gautier, Hien Quang Ta, Lap Luat Nguyen, Anthony Fiche, Mélanie Marazin", "authorCount": 6, "firstAuthorAffiliation": "Univ Brest, CNRS, Lab-STICC, CS 93837, 6 Avenue Le Gorgeu, CEDEX 3, 29238 Brest, France", "isReferencedByCount": 7, "referenceCount": 60, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "University of Western Brittany", "funderIds": "10.13039/501100006703", "url": "https://doi.org/10.3390/s22062204", "pdfUrl": null, "abstract": "The paper proposes a joint semi-blind algorithm for simultaneously cancelling the self-interference component and estimating the propagation channel in 5G Quasi-Cyclic Low-Density Parity-Check (QC-LDPC)-encoded short-packet Full-Duplex (FD) transmissions. To avoid the effect of channel estimation processes when using short-packet transmissions, this semi-blind algorithm was developed by taking into account only a small number (four at least) pilot symbols, which was integrated with the intended information sequence and used for the feedback loop of the estimation of the channels. The results showed that this semi-blind algorithm not only achieved nearly optimal performance, but also significantly reduced the processing time and computational complexity. This semi-blind algorithm can also improve the performances of the Mean-Squared Error (MSE) and Bit Error Rate (BER). The results of this study highlight the potential efficiency of this joint semi-blind iterative algorithm for 5G and Beyond and/or practical IoT transmission scenarios.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s23063191", "doi": "10.3390/s23063191", "title": "Improving Mobile Robot Maneuver Performance Using Fractional-Order Controller", "publicationYear": 2023, "publicationDate": "2023-03-16", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "23", "issue": "6", "page": "3191", "issn": "1424-8220", "isbn": null, "authors": "Daniel Acosta, Bibiana Fariña, Jonay Toledo, Leopoldo Acosta", "authorCount": 4, "firstAuthorAffiliation": "Computer Science and System Department, Universidad de La Laguna, 38200 Canary Island, Spain", "isReferencedByCount": 4, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Spanish Ministry of Science and Technology", "funderIds": null, "url": "https://doi.org/10.3390/s23063191", "pdfUrl": null, "abstract": "In this paper, the low-level velocity controller of an autonomous vehicle is studied. The performance of the traditional controller used in this kind of system, a PID, is analyzed. This kind of controller cannot follow ramp references without error, so when the reference implies a change in the speed, the vehicle cannot follow the proposed reference, and there is a significant difference between the actual and desired vehicle behaviors. A fractional controller is proposed which changes the ordinary dynamics allowing faster responses for small times, at the cost of slower responses for large times. The idea is to take advantage of this fact to follow fast setpoint changes with a smaller error than that obtained with a classic non-fractional PI controller. Using this controller, the vehicle can follow variable speed references with zero stationary error, significantly reducing the difference between reference and actual vehicle behavior. The paper presents the fractional controller, studies its stability in function of the fractional parameters, designs the controller, and tests its stability. The designed controller is tested on a real prototype, and its behavior is compared to a standard PID controller. The designed fractional PID controller overcomes the results of the standard PID controller.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25206421", "doi": "10.3390/s25206421", "title": "A Novel Student Engagement Analysis of Real Classroom Teaching Using Unified Body Orientation Estimation", "publicationYear": 2025, "publicationDate": "2025-10-17", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "20", "page": "6421", "issn": "1424-8220", "isbn": null, "authors": "Yuqing Chen, Jiawen Li, Yixin Liu, Fei Jiang", "authorCount": 4, "firstAuthorAffiliation": "Shanghai Institute of Artificial Intelligence for Education, East China Normal University, Shanghai 200062, China", "isReferencedByCount": 0, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Natural Science Foundation of China", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.3390/s25206421", "pdfUrl": null, "abstract": "Student engagement analysis is closely linked with learning outcomes, and its precise identification paves the way for targeted instruction and personalized learning. Current student engagement methods, reliant on either head pose estimation with facial landmarks or eye-trackers, are hardly generalized to authentic classroom teaching environments with high occlusion and non-intrusive requirements. Based on empirical observations that student body orientation and head pose exhibit a high degree of consistency in classroom settings, we propose a novel student engagement analysis algorithm incorporating human body orientation estimation. To better suit classroom settings, we develop a one-stage and end-to-end trainable framework for multi-person body orientation estimation, named JointBDOE. The proposed JointBDOE integrates human bounding box prediction and body orientation into a unified embedding space, enabling the simultaneous and precise estimation of human positions and orientations in multi-person scenarios. Extensive experimental results using the MEBOW dataset demonstrate the superior performance of JointBDOE over the state-of-the-art methods, with an MAE reduced to 10.63° and orientation accuracy exceeding 91% at 22.5°. With the more challenging reconstructed MEBOW dataset, JointBDOE maintains strong robustness with an MAE of 16.07° and an orientation accuracy of 88.3% at 30°. Further analysis of classroom teaching videos validates the reliability and practical value of body orientation as a robust metric for engagement assessment. This research showcases the potential of artificial intelligence in intelligent classroom analysis and provides an extensible solution for body orientation estimation technology in related fields, advancing the practical application of intelligent educational tools.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s18061712", "doi": "10.3390/s18061712", "title": "HiMeter: Telling You the Height Rather than the Altitude", "publicationYear": 2018, "publicationDate": "2018-05-25", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "18", "issue": "6", "page": "1712", "issn": "1424-8220", "isbn": null, "authors": "Haibo Ye, Kai Dong, Tao Gu", "authorCount": 3, "firstAuthorAffiliation": "College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China", "isReferencedByCount": 21, "referenceCount": 28, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Natural Science Foundation of China", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.3390/s18061712", "pdfUrl": null, "abstract": "The altitude of a moving user is important context information for mobile technologies and applications. However, with the increasing pervasiveness of smartphones and abundant mobile applications, developers and users have gradually discovered that the height is more useful than altitude in many situations. The height is often a relative value, which is the vertical distance to the ground rather than the vertical distance to sea level, and we believe that it is useful in many applications, such as localization/navigation, sport/health and tourism/travel. In this paper, we first carried out a nation-wide online survey to confirm the desirability for the height information in mobile applications, and the result is positive. Then, we proposed HiMeter, an effective and accurate approach to calculating the height of the smartphone. HiMeter makes use of a low-power barometer on the smartphone and does not require GPS or back-server support. We concentrate on the vertical moving pattern of the user and designed several novel techniques, resulting in HiMeter not needing any reference points, and the complex process of calculating the absolute altitude can be avoided. The field studies show that HiMeter can achieve an accuracy of within 5 m in 90% of cases indoors and an accuracy of 10 m in 83% of cases outdoors. Compared to the existing works, HiMeter is more accurate and practical and is more suitable for usage in many mobile applications.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s18061907", "doi": "10.3390/s18061907", "title": "Strain Transfer for Optimal Performance of Sensing Sheet", "publicationYear": 2018, "publicationDate": "2018-06-12", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "18", "issue": "6", "page": "1907", "issn": "1424-8220", "isbn": null, "authors": "Matthew Gerber, Campbell Weaver, Levent E. Aygun, Naveen Verma, James C. Sturm, Branko Glišić", "authorCount": 6, "firstAuthorAffiliation": "Departments of Civil and Environmental Engineering, and Electrical Engineering, Princeton University, Princeton, NJ 08544, USA", "isReferencedByCount": 12, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "US Departmetn of Transportation (DOT)-RITA UTC Program", "funderIds": null, "url": "https://doi.org/10.3390/s18061907", "pdfUrl": null, "abstract": "Sensing sheets based on Large Area Electronics (LAE) and Integrated Circuits (ICs) are novel sensors designed to enable reliable early-stage detection of local unusual structural behaviors. Such a device consists of a dense array of strain sensors, patterned onto a flexible polyimide substrate along with associated electronics. Previous tests performed on steel specimens equipped with sensing sheet prototypes and subjected to fatigue cracking pointed to a potential issue: individual sensors that were on or near a crack would immediately be damaged by the crack, thereby rendering them useless in assessing the size of the crack opening or to monitor future crack growth. In these tests, a stiff adhesive was used to bond the sensing sheet prototype to the steel specimen. Such an adhesive provided excellent strain transfer, but it also caused premature failure of individual sensors within the sheet. Therefore, the aim of this paper is to identify an alternative adhesive that survives minor damage, yet provides strain transfer that is sufficient for reliable early-stage crack detection. A sensor sheet prototype is then calibrated for use with the selected adhesive.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s24113612", "doi": "10.3390/s24113612", "title": "Activity-Based Prospective Memory in Insomniacs", "publicationYear": 2024, "publicationDate": "2024-06-03", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "24", "issue": "11", "page": "3612", "issn": "1424-8220", "isbn": null, "authors": "Miranda Occhionero, Lorenzo Tonetti, Federica Giudetti, Vincenzo Natale", "authorCount": 4, "firstAuthorAffiliation": "Department of Psychology “Renzo Canestrari”, University of Bologna, 40127 Bologna, Italy", "isReferencedByCount": 2, "referenceCount": 52, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s24113612", "pdfUrl": null, "abstract": "Objective: To investigate the activity-based prospective memory performance in patients with insomnia, divided, on the basis of actigraphic evaluation, into sleep onset, maintenance, mixed and negative misperception insomnia. Methods: A total of 153 patients with insomnia (I, 83 females, mean age + SD = 41.37 + 16.19 years) and 121 healthy controls (HC, 78 females, mean age + SD = 36.99 + 14.91 years) wore an actigraph for one week. Insomnia was classified into sleep onset insomnia (SOI), maintenance insomnia (MaI), mixed insomnia (MixI) and negative misperception insomnia (NMI). To study their activity-based prospective memory performance, all the participants were required to push the actigraph event marker button twice, at bedtime (task 1) and at get-up time (task 2). Results: Only patients with maintenance and mixed insomnia had a significantly lower accuracy in the activity-based prospective memory task at get-up time compared with the healthy controls. Conclusion: The results show that maintenance and mixed insomnia involve an impaired activity-based prospective memory performance, while sleep onset and negative misperception insomnia do not seem to be affected. This pattern of results suggests that the fragmentation of sleep may play a role in activity-based prospective memory efficiency at wake-up in the morning.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s150715311", "doi": "10.3390/s150715311", "title": "Sensorless FOC Performance Improved with On-Line Speed and Rotor Resistance Estimator Based on an Artificial Neural Network for an Induction Motor Drive", "publicationYear": 2015, "publicationDate": "2015-06-29", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "15", "issue": "7", "page": "15311-15325", "issn": "1424-8220", "isbn": null, "authors": "Jose Gutierrez-Villalobos, Juvenal Rodriguez-Resendiz, Edgar Rivas-Araiza, Moisés Martínez-Hernández", "authorCount": 4, "firstAuthorAffiliation": "Laboratorio de Mecatrónica, Universidad Autónoma de Querétaro, Cerro de las Campanas,  Col. Las Campanas, S/N, Queretaro 76010, Mexico", "isReferencedByCount": 12, "referenceCount": 15, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s150715311", "pdfUrl": null, "abstract": "Three-phase induction motor drive requires high accuracy in high performance processes in industrial applications. Field oriented control, which is one of the most employed control schemes for induction motors, bases its function on the electrical parameter estimation coming from the motor. These parameters make an electrical machine driver work improperly, since these electrical parameter values change at low speeds, temperature changes, and especially with load and duty changes. The focus of this paper is the real-time and on-line electrical parameters with a CMAC-ADALINE block added in the standard FOC scheme to improve the IM driver performance and endure the driver and the induction motor lifetime. Two kinds of neural network structures are used; one to estimate rotor speed and the other one to estimate rotor resistance of an induction motor.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s21144814", "doi": "10.3390/s21144814", "title": "Rapid and Sensitive Inhibitor Screening Using Magnetically Modulated Biosensors", "publicationYear": 2021, "publicationDate": "2021-07-14", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "21", "issue": "14", "page": "4814", "issn": "1424-8220", "isbn": null, "authors": "Shira Roth, Amos Danielli", "authorCount": 2, "firstAuthorAffiliation": "Faculty of Engineering, The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Max and Anna Webb Street, Ramat Gan 5290002, Israel", "isReferencedByCount": 8, "referenceCount": 49, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Ministry of Science and Technology, Israel, Bar-Ilan Dangoor Centre for Personalized Medicine", "funderIds": "10.13039/501100006245", "url": "https://doi.org/10.3390/s21144814", "pdfUrl": null, "abstract": "Inhibitor screening is an important tool for drug development, especially during the COVID-19 pandemic. The most used in vitro inhibitor screening tool is an enzyme-linked immunosorbent assay (ELISA). However, ELISA-based inhibitor screening is time consuming and has a limited dynamic range. Using fluorescently and magnetically modulated biosensors (MMB), we developed a rapid and sensitive inhibitor screening tool. This study demonstrates its performance by screening small molecules and neutralizing antibodies as potential inhibitors of the interaction between the spike protein 1 (S1) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the angiotensin-converting enzyme 2 (ACE2) receptor. The MMB-based assay is highly sensitive, has minimal non-specific binding, and is much faster than the commonly used ELISA (2 h vs. 7–24 h). We anticipate that our method will lead to a remarkable advance in screening for new drug candidates.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s150305376", "doi": "10.3390/s150305376", "title": "A Portable Automatic Endpoint Detection System for Amplicons of Loop Mediated Isothermal Amplification on Microfluidic Compact Disk Platform", "publicationYear": 2015, "publicationDate": "2015-03-05", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "15", "issue": "3", "page": "5376-5389", "issn": "1424-8220", "isbn": null, "authors": "Shah Uddin, Fatimah Ibrahim, Abkar Sayad, Aung Thiha, Koh Pei, Mas Mohktar, Uda Hashim, Jongman Cho, Kwai Thong", "authorCount": 9, "firstAuthorAffiliation": "Department of Biomedical Engineering, Faculty of Engineering, University of Malaya,  50603 Kuala Lumpur, Malaysia", "isReferencedByCount": 29, "referenceCount": 61, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s150305376", "pdfUrl": null, "abstract": "In recent years, many improvements have been made in foodborne pathogen detection methods to reduce the impact of food contamination. Several rapid methods have been developed with biosensor devices to improve the way of performing pathogen detection. This paper presents an automated endpoint detection system for amplicons generated by loop mediated isothermal amplification (LAMP) on a microfluidic compact disk platform. The developed detection system utilizes a monochromatic ultraviolet (UV) emitter for excitation of fluorescent labeled LAMP amplicons and a color sensor to detect the emitted florescence from target. Then it processes the sensor output and displays the detection results on liquid crystal display (LCD). The sensitivity test has been performed with detection limit up to 2.5 × 10−3 ng/µL with different DNA concentrations of Salmonella bacteria. This system allows a rapid and automatic endpoint detection which could lead to the development of a point-of-care diagnosis device for foodborne pathogens detection in a resource-limited environment.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s22051718", "doi": "10.3390/s22051718", "title": "Research on Small Sample Dynamic Human Ear Recognition Based on Deep Learning", "publicationYear": 2022, "publicationDate": "2022-02-22", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "22", "issue": "5", "page": "1718", "issn": "1424-8220", "isbn": null, "authors": "Yanmin Lei, Junru Qian, Dong Pan, Tingfa Xu", "authorCount": 4, "firstAuthorAffiliation": "Department of Electrical and Information Engineering, Changchun University, Changchun 130012, China", "isReferencedByCount": 11, "referenceCount": 19, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Science and Technology Planning Project of Jilin Province Science and Technology Department, National Natural Science Foundation of China", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.3390/s22051718", "pdfUrl": null, "abstract": "Due to the problem of insufficient dynamic human ear data, the Changchun University dynamic human ear (CCU-DE) database, which is a small sample human ear database, was developed in this study. The database fully considers the various complex situations and posture changes of human ear images, such as translation angle, rotation angle, illumination change, occlusion and interference, etc., making the research of dynamic human ear recognition closer to complex real-life situations, and increasing the applicability of human ear dynamic recognition. In order to test the practicability and effectiveness of the developed CCU-DE small sample database, we designed a dynamic human ear recognition system block diagram based on a deep learning model, which was pre-trained by a migration learning method. Aiming at multi-posture changes under different contrasts, translation and rotation motions, and with or without occlusion, simulation studies were conducted using the CCU-DE small sample database and different deep learning models, such as YOLOv3, YOLOv4, YOLOv5, Faster R-CNN, and SSD. The experimental results showed that the CCU-DE database can be well used for dynamic ear recognition, and it can be tested by using different deep learning models with higher test accuracy.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s110201246", "doi": "10.3390/s110201246", "title": "A Refrigerated Web Camera for Photogrammetric Video Measurement inside Biomass Boilers and Combustion Analysis", "publicationYear": 2011, "publicationDate": "2011-01-25", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "11", "issue": "2", "page": "1246-1260", "issn": "1424-8220", "isbn": null, "authors": "Jacobo Porteiro, Belén Riveiro, Enrique Granada, Julia Armesto, Pablo Eguía, Joaquín Collazo", "authorCount": 6, "firstAuthorAffiliation": "ETS Ingenieros Industriales, University of Vigo, Lagoas-Marcosende s/n 36200—Vigo, Spain", "isReferencedByCount": 5, "referenceCount": 26, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/3.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s110201246", "pdfUrl": null, "abstract": "This paper describes a prototype instrumentation system for photogrammetric measuring of bed and ash layers, as well as for flying particle detection and pursuit using a single device (CCD) web camera. The system was designed to obtain images of the combustion process in the interior of a domestic boiler. It includes a cooling system, needed because of the high temperatures in the combustion chamber of the boiler. The cooling system was designed using CFD simulations to ensure effectiveness. This method allows more complete and real-time monitoring of the combustion process taking place inside a boiler. The information gained from this system may facilitate the optimisation of boiler processes.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s100301553", "doi": "10.3390/s100301553", "title": "Geometric Stability and Lens Decentering in Compact Digital Cameras", "publicationYear": 2010, "publicationDate": "2010-03-01", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "10", "issue": "3", "page": "1553-1572", "issn": "1424-8220", "isbn": null, "authors": "Enoc Sanz-Ablanedo, José Ramón Rodríguez-Pérez, Julia Armesto, María Flor Álvarez Taboada", "authorCount": 4, "firstAuthorAffiliation": "Geomatics Engineering Research Group. University of León, Avda. Astorga s/n, 24400 Ponferrada, Spain", "isReferencedByCount": 16, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/3.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s100301553", "pdfUrl": null, "abstract": "A study on the geometric stability and decentering present in sensor-lens systems of six identical compact digital cameras has been conducted. With regard to geometrical stability, the variation of internal geometry parameters (principal distance, principal point position and distortion parameters) was considered. With regard to lens decentering, the amount of radial and tangential displacement resulting from decentering distortion was related with the precision of the camera and with the offset of the principal point from the geometric center of the sensor. The study was conducted with data obtained after 372 calibration processes (62 per camera). The tests were performed for each camera in three situations: during continuous use of the cameras, after camera power off/on and after the full extension and retraction of the zoom-lens. Additionally, 360 new calibrations were performed in order to study the variation of the internal geometry when the camera is rotated. The aim of this study was to relate the level of stability and decentering in a camera with the precision and quality that can be obtained. An additional goal was to provide practical recommendations about photogrammetric use of such cameras.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25030883", "doi": "10.3390/s25030883", "title": "Cascade Sliding Mode Control for Linear Displacement Positioning of a Quadrotor", "publicationYear": 2025, "publicationDate": "2025-01-31", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "3", "page": "883", "issn": "1424-8220", "isbn": null, "authors": "Albert Sawiński, Piotr Chudzik, Karol Tatar", "authorCount": 3, "firstAuthorAffiliation": "Institute of Automatic Control, Faculty of Electrical, Electronic, Computer and Control Engineering, Lodz University of Technology, 90-924 Łódź, Poland", "isReferencedByCount": 2, "referenceCount": 35, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s25030883", "pdfUrl": null, "abstract": "This paper contains an example of a simulation implementation of sliding mode control algorithms for the problem of adjusting the linear position of a quadrotor. A mathematical model of the drone was proposed, which was then implemented in a simulation environment. The method of designing sliding mode controllers using the Lyapunov method in order to improve stability was presented. A cascade system based entirely on sliding mode control algorithms is introduced. The article ends with a comparative analysis of simulation test results of classical control systems and controllers based on sliding mode control.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25082356", "doi": "10.3390/s25082356", "title": "Thermography in Bike Fitting: A Literature Review", "publicationYear": 2025, "publicationDate": "2025-04-08", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "8", "page": "2356", "issn": "1424-8220", "isbn": null, "authors": "Warre Clarys, Oscar Vallet, Jan Verstockt, Hai Zhang, Simon Verspeek, Gunther Steenackers", "authorCount": 6, "firstAuthorAffiliation": "InViLab Research Group, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium", "isReferencedByCount": 0, "referenceCount": 49, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Research Foundation-Flanders (FWO), VLAIO Tetra project", "funderIds": "10.13039/501100003130, 10.13039/100012331", "url": "https://doi.org/10.3390/s25082356", "pdfUrl": null, "abstract": "Cycling comfort significantly impacts both enjoyment and performance, with discomfort potentially leading to injuries. Traditional bike-fitting methods, while effective for biomechanical adjustments, often overlook physiological responses such as pressure distribution and asymmetry. Infrared thermography (IRT), a non-invasive technique analyzing surface temperature variations, offers the potential to enhance bike fitting by identifying pressure points, asymmetries, and discomfort zones. This review evaluates the application of IRT in bike fitting, highlighting its ability to provide objective, real-time insights into cyclist comfort and injury prevention. However, limitations such as variability in thermographic protocols and the lack of standardized methodologies necessitate further research. By addressing these gaps, IRT could transform bike fitting into a more precise, personalized, and effective practice for cyclists across all levels.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25072055", "doi": "10.3390/s25072055", "title": "Simulation Analysis and Experimental Verification of High-Speed Impact of Rocky Asteroids", "publicationYear": 2025, "publicationDate": "2025-03-25", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "7", "page": "2055", "issn": "1424-8220", "isbn": null, "authors": "Fan Huang, Zhiqing Geng, Binqiang Luo, Yuming Peng, Liang Xu, Wei Wang, Biyue Pan, Dongyu Li", "authorCount": 8, "firstAuthorAffiliation": "School of Instrument science and Engineering, Southeast University, Nanjing 201100, China", "isReferencedByCount": 0, "referenceCount": 23, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Preliminary Research Project", "funderIds": null, "url": "https://doi.org/10.3390/s25072055", "pdfUrl": null, "abstract": "Kinetic impact is an effective way to deal with threatening asteroids, and the momentum transfer coefficient during the impact process is an effective indicator for evaluating the impact effect. This article is based on the use of the Smoothed Particle Hydrodynamics (SPH) method to establish a simulation model of high-speed impact of flying discs on granite targets, and obtain parameters such as the shape of the splashing material and the distribution of the target damage during the impact process. An analysis was conducted on the influence of different impact velocities on the kinetic energy transfer coefficient, and it was found that the momentum transfer coefficient increased with the increase in impact velocity, from 1.59 at 5 km/s to 1.96 at 11.7 km/s. A ground high-speed impact system with a speed of over 10 km/s has been established, and the actual momentum transfer coefficient has increased from 1.73 at 7 km/s to around 2.06 at 11.7 km/s. The variation trend of kinetic energy transfer coefficients obtained from experiments and simulations is consistent, with an error of basically within 10%, and the simulation results are effective. The simulation and experimental analysis of high-speed kinetic impact can provide a reference for the engineering implementation of asteroid impact defense missions.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25072199", "doi": "10.3390/s25072199", "title": "Target Detection Method for Soil-Dwelling Termite Damage Based on MCD-YOLOv8", "publicationYear": 2025, "publicationDate": "2025-03-31", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "7", "page": "2199", "issn": "1424-8220", "isbn": null, "authors": "Peidong Jiang, Lai Jiang, Fengyan Wu, Tengteng Che, Ming Wang, Chuandong Zheng", "authorCount": 6, "firstAuthorAffiliation": "Hubei Water Resources Research Institute, Wuhan 430070, China", "isReferencedByCount": 1, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Key Research and Development Program of China, National Natural Science Foundation of China", "funderIds": null, "url": "https://doi.org/10.3390/s25072199", "pdfUrl": null, "abstract": "With global climate change and the deterioration of the ecological environment, the safety of hydraulic engineering faces severe challenges, among which soil-dwelling termite damage has become an issue that cannot be ignored. Reservoirs and embankments in China, primarily composed of earth and rocks, are often affected by soil-dwelling termites, such as Odontotermes formosanus and Macrotermes barneyi. Identifying soil-dwelling termite damage is crucial for implementing monitoring, early warning, and control strategies. This study developed an improved YOLOv8 model, named MCD-YOLOv8, for identifying traces of soil-dwelling termite activity, based on the Monte Carlo random sampling algorithm and a lightweight module. The Monte Carlo attention (MCA) module was introduced in the backbone part to generate attention maps through random sampling pooling operations, addressing cross-scale issues and improving the recognition accuracy of small targets. A lightweight module, known as dimension-aware selective integration (DASI), was added in the neck part to reduce computation time and memory consumption, enhancing detection accuracy and speed. The model was verified using a dataset of 2096 images from the termite damage survey in hydraulic engineering within Hubei Province in 2024, along with images captured by drone. The results showed that the improved YOLOv8 model outperformed four traditional or enhanced models in terms of precision and mean average precision for detecting soil-dwelling termite damage, while also exhibiting fewer parameters, reduced redundancy in detection boxes, and improved accuracy in detecting small targets. Specifically, the MCD-YOLOv8 model achieved increases in precision and mean average precision of 6.4% and 2.4%, respectively, compared to the YOLOv8 model, while simultaneously reducing the number of parameters by 105,320. The developed model is suitable for the intelligent identification of termite damage in complex environments, thereby enhancing the intelligent monitoring of termite activity and providing strong technical support for the development of termite control technologies.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25144315", "doi": "10.3390/s25144315", "title": "A Stability- and Aggregation-Based Method for Heart Rate Estimation Using Photoplethysmographic Signals During Physical Activity", "publicationYear": 2025, "publicationDate": "2025-07-10", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "14", "page": "4315", "issn": "1424-8220", "isbn": null, "authors": "Sabrina C. Crepaldi, Jiabin Wang, Fumiya Matsumoto, Hiroki Takeuchi, Tatsuhiko Watanabe, Yoshiharu Yamamoto", "authorCount": 6, "firstAuthorAffiliation": "SOXAI Inc., Kanagawa 231-0032, Japan", "isReferencedByCount": 0, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Japan Science and Technology (JST) Agency MOONSHOT R&amp;D", "funderIds": null, "url": "https://doi.org/10.3390/s25144315", "pdfUrl": null, "abstract": "In recent years, the use of photoplethysmography (PPG)-based heart rate detection has gained considerable attention as a cost-effective alternative to conventional electrocardiography (ECG) for applications in healthcare and fitness tracking. Although deep learning methods have shown promise in heart rate estimation and motion artifact removal from PPG signals recorded during physical activity, their computational requirements and need for extensive training data make them less practical for real-world conditions when ground truth data is unavailable for calibration. This study presents a one-size-fits-all approach for heart rate estimation during physical activity that employs aggregation-based techniques to track heart rate and minimize the effects of motion artifacts, without relying on complex machine learning or deep learning techniques. We evaluate our method on four publicly available datasets—PPG-DaLiA, WESAD, IEEE_Training, and IEEE_Test, all recorded using wrist-worn devices—along with a new dataset, UTOKYO, which includes PPG and accelerometer data collected from a smart ring. The proposed method outperforms the CNN ensemble model for the PPG-DaLiA dataset and the IEEE_Test dataset and reduces the mean absolute error (MAE) by 1.45 bpm and 5.71 bpm, respectively, demonstrating that effective signal processing techniques can match the performance of more complex deep learning models without requiring extensive computational resources or dataset-specific tuning.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25196204", "doi": "10.3390/s25196204", "title": "Motor Imagery Acquisition Paradigms: In the Search to Improve Classification Accuracy", "publicationYear": 2025, "publicationDate": "2025-10-07", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "19", "page": "6204", "issn": "1424-8220", "isbn": null, "authors": "David Reyes, Sebastian Sieghartsleitner, Humberto Loaiza, Christoph Guger", "authorCount": 4, "firstAuthorAffiliation": "School of Electrical and Electronics Engineering, University of Valle, Cali 760032, Colombia", "isReferencedByCount": 0, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "COLFUTURO—Fundación para el Futuro de Colombia", "funderIds": "10.13039/501100010459", "url": "https://doi.org/10.3390/s25196204", "pdfUrl": null, "abstract": "In recent years, advances in medicine have been evident thanks to technological growth and interdisciplinary research, which has allowed the integration of knowledge, for example, of engineering into medical fields. This integration has generated developments and new methods that can be applied in alternative situations, highlighting, for example, aspects related to post-stroke therapies, Multiple Sclerosis (MS), or Spinal Cord Injury (SCI) treatments. One of the methods that has stood out and is gaining more acceptance every day is Brain–Computer Interfaces (BCIs), through the acquisition and processing of brain electrical activity, researchers, doctors, and scientists manage to transform this activity into control signals. In turn, there are several methods for operating a BCI, this work will focus on motor imagery (MI)-based BCI and three types of acquisition paradigms (traditional arrow, picture, and video), seeking to improve the accuracy in the classification of motor imagination tasks for naive subjects, which correspond to a MI task for both the left and the right hand. A pipeline and methodology were implemented using the CAR+CSP algorithm to extract the features and simple standard and widely used models such as LDA and SVM for classification. The methodology was tested with post-stroke (PS) subject data with BCI experience, obtaining 96.25% accuracy for the best performance, and with the novel paradigm proposed for the naive subjects, 97.5% was obtained. Several statistical tests were carried out in order to find differences between paradigms within the collected data. In conclusion, it was found that the classification accuracy could be improved by using different strategies in the acquisition stage.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25185622", "doi": "10.3390/s25185622", "title": "Design Considerations for a 120 GHz MIMO Sparse Radar Array Based on SISO Integrated Circuits", "publicationYear": 2025, "publicationDate": "2025-09-09", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "18", "page": "5622", "issn": "1424-8220", "isbn": null, "authors": "Luigi Ferro, Changzhi Li, Emanuele Cardillo", "authorCount": 3, "firstAuthorAffiliation": "Department of Engineering, University of Messina, 98166 Messina, Italy", "isReferencedByCount": 0, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s25185622", "pdfUrl": null, "abstract": "This study aims to illustrate the main aspects of designing a modular 120 GHz Multiple-Input Multiple-Output (MIMO) sparse radar array (SRA) composed of multiple Single-Input Single-Output (SISO) Integrated Circuits (ICs). Although the scientific literature reports on 120 GHz integrated circuit prototypes, to the authors’ best knowledge, there are no commercial MIMO radars composed of multiple SISO ICs operating in the D-band spectrum. The design involves many challenges; indeed, the necessity to combine multiple chips with fixed dimensions and the presence of transmitting and receiving antennas on chips add many constraints for the antenna placement and, consequently, for the virtual array design. As an example, the minimum distance between the antennas must be at least equal to the chip width, which is in turn higher than half a wavelength and renders the array into a sparse configuration, thus raising many concerns regarding fixing the optimum inter-chip distance. Thus, this contribution can be considered as pioneering, being focused on the emerging concept of designing D-band MIMO radars by exploiting a modular approach.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25185787", "doi": "10.3390/s25185787", "title": "Integrating Inertial Sensors to Assess Physical Performance and In-Match Demands for the International Selection of Cerebral Palsy Football Players", "publicationYear": 2025, "publicationDate": "2025-09-17", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "18", "page": "5787", "issn": "1424-8220", "isbn": null, "authors": "Juan F. Maggiolo, Raúl Reina, Manuel Moya-Ramón, Iván Peña-González", "authorCount": 4, "firstAuthorAffiliation": "Department of Sports Sciences, Sports Research Centre, Miguel Hernández University of Elche, 03202 Elche, Spain", "isReferencedByCount": 0, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s25185787", "pdfUrl": null, "abstract": "This study analyzed the physical performance (via field tests) and in-match physical responses (via wearable inertial sensors) of national and international cerebral palsy (CP) football players competing in Spain’s First Division. A total of 80 players (FT1: n = 22; FT2: n = 48; FT3: n = 10) completed sprinting, change of direction, and dribbling tests. In-match data from 74 players were collected across 56 official matches. Players were classified as “international” (candidates for the national team) or “national” (non-candidates). Statistical analyses identified performance differences and predictors of international selection using multiple discriminant analysis. International players outperformed national ones in sprinting, agility, and dribbling, especially in FT1 and FT2 classes (p &lt; 0.05; large effect sizes). In-match data (analyzed for FT2 only) showed that international players covered more distance at all intensities and executed more high-intensity actions (e.g., maximal velocity, ball contacts). High-intensity running was the strongest predictor of international status (74.5%, Wilks’ λ = 0.86, p = 0.01). Change of direction and dribbling were key discriminators in FT1 and FT2, while no clear predictor emerged in FT3. These findings support the use of physical tests and wearable technology for evidence-based talent identification and selection in CP football.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25185876", "doi": "10.3390/s25185876", "title": "Image Processing Algorithms Analysis for Roadside Wild Animal Detection", "publicationYear": 2025, "publicationDate": "2025-09-19", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "18", "page": "5876", "issn": "1424-8220", "isbn": null, "authors": "Mindaugas Knyva, Darius Gailius, Šarūnas Kilius, Aistė Kukanauskaitė, Pranas Kuzas, Gintautas Balčiūnas, Asta Meškuotienė, Justina Dobilienė", "authorCount": 8, "firstAuthorAffiliation": "Department of Electronics Engineering, Kaunas University of Technology, Studentu Str. 50-457, 51368 Kaunas, Lithuania", "isReferencedByCount": 0, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s25185876", "pdfUrl": null, "abstract": "The study presents a comparative analysis of five distinct image processing methodologies for roadside wild animal detection using thermal imagery, aiming to identify an optimal approach for embedded system implementation to mitigate wildlife–vehicle collisions. The evaluated techniques included the following: bilateral filtering followed by thresholding and SIFT feature matching; Gaussian filtering combined with Canny edge detection and contour analysis; color quantization via the nearest average algorithm followed by contour identification; motion detection based on absolute inter-frame differencing, object dilation, thresholding, and contour comparison; and animal detection based on a YOLOv8n neural network. These algorithms were applied to sequential thermal images captured by a custom roadside surveillance system incorporating a thermal camera and a Raspberry Pi processing unit. Performance evaluation utilized a dataset of consecutive frames, assessing average execution time, sensitivity, specificity, and accuracy. The results revealed performance trade-offs: the motion detection method achieved the highest sensitivity (92.31%) and overall accuracy (87.50%), critical for minimizing missed detections, despite exhibiting the near lowest specificity (66.67%) and a moderate execution time (0.126 s) compared to the fastest bilateral filter approach (0.093 s) and the high-specificity Canny edge method (90.00%). Consequently, considering the paramount importance of detection reliability (sensitivity and accuracy) in this application, the motion-based methodology was selected for further development and implementation within the target embedded system framework. Subsequent testing on diverse datasets validated its general robustness while highlighting potential performance variations depending on dataset characteristics, particularly the duration of animal presence within the monitored frame.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25123680", "doi": "10.3390/s25123680", "title": "High Sensitivity SERS Substrate with Femtosecond Laser-Printed Nanohole Arrays", "publicationYear": 2025, "publicationDate": "2025-06-12", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "12", "page": "3680", "issn": "1424-8220", "isbn": null, "authors": "Yunfang Zhang, Dejun Liu, Han Liu, Yubin Deng, Zhiyong Bai, Changrui Liao, Yiping Wang, Ying Wang", "authorCount": 8, "firstAuthorAffiliation": "Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things, Guangdong and Hong Kong Joint Research Centre for Optical Fibre Sensors, State Key Laboratory of Radio Frequency Heterogeneous Integration, Shenzhen University, Shenzhen 518060, China", "isReferencedByCount": 0, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Shenzhen Science and Technology Program, Shenzhen Key Laboratory of Ultrafast Laser Micro/Nano Manufacturing, Guangdong Basic and Applied Basic Research Foundation, National Natural Science Foundation of China, Research Team Cultivation Program of Shenzhen University, Medicine Plus Program of Shenzhen University, Scientific Foundation for Youth Scholars of Shenzhen University", "funderIds": null, "url": "https://doi.org/10.3390/s25123680", "pdfUrl": null, "abstract": "This article presents a novel method for fabricating repeatable and uniform surface-enhanced Raman scattering (SERS) substrates. The proposed method consists of two steps: (1) the fabrication of nanohole arrays using advanced femtosecond laser-induced two-photon polymerization (TPP) technology; and (2) the deposition of 9 nm thick silver nanoparticles on the nanohole arrays. The proposed nanohole arrays were optimized at the diameter, and the thickness of the silver film at two parameters. Regarding SERS substrates, a limit of detection of 10−10 M (rhodamine 6G) and analytical enhancement factors up to 3.5 × 104 were achieved. At 1361 cm−1, the relative standard deviation (RSD) of the characteristic peak was 5.5%, demonstrating a highly reproducible SERS substrate.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25113395", "doi": "10.3390/s25113395", "title": "DynaFusion-SLAM: Multi-Sensor Fusion and Dynamic Optimization of Autonomous Navigation Algorithms for Pasture-Pushing Robot", "publicationYear": 2025, "publicationDate": "2025-05-28", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "11", "page": "3395", "issn": "1424-8220", "isbn": null, "authors": "Zhiwei Liu, Jiandong Fang, Yudong Zhao", "authorCount": 3, "firstAuthorAffiliation": "College of Information Engineering, Inner Mongolia University of Technology, Hohhot 010080, China", "isReferencedByCount": 1, "referenceCount": 26, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Inner Mongolia Scientific and Technological Project, Basic Research Operating Costs of Colleges and Universities directly under the Inner Mongolia Autonomous Region", "funderIds": null, "url": "https://doi.org/10.3390/s25113395", "pdfUrl": null, "abstract": "Aiming to address the problems of fewer related studies on autonomous navigation algorithms based on multi-sensor fusion in complex scenarios in pastures, lower degrees of fusion, and insufficient cruising accuracy of the operation path in complex outdoor environments, a multimodal autonomous navigation system is proposed based on a loosely coupled architecture of Cartographer–RTAB-Map (real-time appearance-based mapping). Through laser-vision inertial guidance multi-sensor data fusion, the system achieves high-precision mapping and robust path planning in complex scenes. First, comparing the mainstream laser SLAM algorithms (Hector/Gmapping/Cartographer) through simulation experiments, Cartographer is found to have a significant memory efficiency advantage in large-scale scenarios and is thus chosen as the front-end odometer. Secondly, a two-way position optimization mechanism is innovatively designed: (1) When building the map, Cartographer processes the laser with IMU and odometer data to generate mileage estimations, which provide positioning compensation for RTAB-Map. (2) RTAB-Map fuses the depth camera point cloud and laser data, corrects the global position through visual closed-loop detection, and then uses 2D localization to construct a bimodal environment representation containing a 2D raster map and a 3D point cloud, achieving a complete description of the simulated ranch environment and material morphology and constructing a framework for the navigation algorithm of the pushing robot based on the two types of fused data. During navigation, the combination of RTAB-Map’s global localization and AMCL’s local localization is used to generate a smoother and robust positional attitude by fusing IMU and odometer data through the EKF algorithm. Global path planning is performed using Dijkstra’s algorithm and combined with the TEB (Timed Elastic Band) algorithm for local path planning. Finally, experimental validation is performed in a laboratory-simulated pasture environment. The results indicate that when the RTAB-Map algorithm fuses with the multi-source odometry, its performance is significantly improved in the laboratory-simulated ranch scenario, the maximum absolute value of the error of the map measurement size is narrowed from 24.908 cm to 4.456 cm, the maximum absolute value of the relative error is reduced from 6.227% to 2.025%, and the absolute value of the error at each location is significantly reduced. At the same time, the introduction of multi-source mileage fusion can effectively avoid the phenomenon of large-scale offset or drift in the process of map construction. On this basis, the robot constructs a fusion map containing a simulated pasture environment and material patterns. In the navigation accuracy test experiments, our proposed method reduces the root mean square error (RMSE) coefficient by 1.7% and Std by 2.7% compared with that of RTAB-MAP. The RMSE is reduced by 26.7% and Std by 22.8% compared to that of the AMCL algorithm. On this basis, the robot successfully traverses the six preset points, and the measured X and Y directions and the overall position errors of the six points meet the requirements of the pasture-pushing task. The robot successfully returns to the starting point after completing the task of multi-point navigation, achieving autonomous navigation of the robot.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25144467", "doi": "10.3390/s25144467", "title": "How to Talk to Your Classifier: Conditional Text Generation with Radar–Visual Latent Space", "publicationYear": 2025, "publicationDate": "2025-07-17", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "14", "page": "4467", "issn": "1424-8220", "isbn": null, "authors": "Julius Ott, Huawei Sun, Lorenzo Servadei, Robert Wille", "authorCount": 4, "firstAuthorAffiliation": "Infineon Technologies AG, 85579 Neubiberg, Germany", "isReferencedByCount": 0, "referenceCount": 49, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s25144467", "pdfUrl": null, "abstract": "Many radar applications rely primarily on visual classification for their evaluations. However, new research is integrating textual descriptions alongside visual input and showing that such multimodal fusion improves contextual understanding. A critical issue in this area is the effective alignment of coded text with corresponding images. To this end, our paper presents an adversarial training framework that generates descriptive text from the latent space of a visual radar classifier. Our quantitative evaluations show that this dual-task approach maintains a robust classification accuracy of 98.3% despite the inclusion of Gaussian-distributed latent spaces. Beyond these numerical validations, we conduct a qualitative study of the text output in relation to the classifier’s predictions. This analysis highlights the correlation between the generated descriptions and the assigned categories and provides insight into the classifier’s visual interpretation processes, particularly in the context of normally uninterpretable radar data.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25175290", "doi": "10.3390/s25175290", "title": "A Rapid Segmentation Method Based on Few-Shot Learning: A Case Study on Roadways", "publicationYear": 2025, "publicationDate": "2025-08-26", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "17", "page": "5290", "issn": "1424-8220", "isbn": null, "authors": "He Cai, Jiangchuan Chen, Yunfei Yin, Junpeng Yu, Zejiao Dong", "authorCount": 5, "firstAuthorAffiliation": "School of Transportation Science and Engineering, Harbin Institute of Technology, Nangang District, Harbin 150006, China", "isReferencedByCount": 0, "referenceCount": 37, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Key R&amp;D Program of China, National Natural Science Foundation of China, China Postdoctoral Science Foundation, Heilongjiang Postdoctoral Science Foundation, Fundamental Research Funds for the Central Universities", "funderIds": "10.13039/501100012166", "url": "https://doi.org/10.3390/s25175290", "pdfUrl": null, "abstract": "Currently, deep learning-based segmentation methods are capable of achieving accurate segmentation. However, their deployment and training are costly and resource-intensive. To reduce deployment costs and facilitate the application of segmentation models for road imagery, this paper introduces a novel road segmentation algorithm based on few-shot learning. The algorithm consists of the back-projection module (BPM), responsible for generating target probabilities, and the segmentation module (SM), which performs image segmentation based on these probabilities. To achieve precise segmentation, the paper proposes a learning mechanism that simultaneously considers both positive and negative samples, effectively capturing the color features of the environment and objects. Additionally, through the workflow design, the algorithm can rapidly perform segmentation tasks across different scenarios without requiring transfer learning and with minimal sample prompts. Experimental results show that the algorithm achieves intersection over union segmentation accuracies of 94.9%, 92.7%, 94.9%, and 94.7% across different scenarios. Compared to state-of-the-art methods, it delivers precise segmentation with fewer local road image prompts, enabling efficient edge deployment.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25154675", "doi": "10.3390/s25154675", "title": "An Anti-Range-Deception-Jamming Method for Networked Moving Radar Based on Trajectory Optimization", "publicationYear": 2025, "publicationDate": "2025-07-29", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "15", "page": "4675", "issn": "1424-8220", "isbn": null, "authors": "Xiaofei Han, Huafeng He, Chuan He, Qi Zhang, Liyuan Wang, Tao Zhou, Xin Zhang", "authorCount": 7, "firstAuthorAffiliation": "Department of Control Engineering, Rocket Force University of Engineering, Xi’an 710025, China", "isReferencedByCount": 0, "referenceCount": 37, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Natural Science Foundation of China, Special Support Plan for High level Talents in Shaanxi Province, Rocket Force University of Engineering Foundation for Young Scientists", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.3390/s25154675", "pdfUrl": null, "abstract": "Aiming at the problem that the anti-range-deception-jamming effect of a networked moving radar system is severely affected by the spatial distribution of each radar, an anti-range-deception-jamming method for networked moving radar based on trajectory optimization is proposed. Firstly, the anti-jamming method of networked moving radar considering the radar position error (RPE) is proposed. Then, the theoretical expression for the false target (FT) misjudgment probability of networked moving radar is deduced. Based on the theoretical expression, a trajectory optimization model is formulated to minimize FT misjudgment probability. Simulation experiments validate both the correctness of the derived probability expression and the significant influence of the radar spatial distribution position on the FT misjudgment probability. Moreover, the simulation results verify that the proposed anti-jamming method can effectively reduce the FT misjudgment probability of networked moving radar under the condition of a high discrimination probability of the physical target (PT).", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25175322", "doi": "10.3390/s25175322", "title": "Model of an Open-Source MicroPython Library for GSM NB-IoT", "publicationYear": 2025, "publicationDate": "2025-08-27", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "17", "page": "5322", "issn": "1424-8220", "isbn": null, "authors": "Antonii Lupandin, Volodymyr Kopieikin, Maksym Khruslov, Iryna Artyshchuk, Ruslan Shevchuk", "authorCount": 5, "firstAuthorAffiliation": "Department of Computer Systems and Robotics, Educational and Scientific Institute of Computer Science and Artificial Intelligence, V. N. Karazin Kharkiv National University, 61022 Kharkiv, Ukraine", "isReferencedByCount": 0, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s25175322", "pdfUrl": null, "abstract": "The growing adoption of the Internet of Things (IoT) demands scalable, energy-efficient communication for autonomous devices. Narrowband IoT (NB-IoT), as a low-power wide-area technology, offers reliable connectivity but remains difficult to integrate in MicroPython systems due to the absence of high-level GSM libraries. This paper introduces a modular, object-oriented MicroPython library that abstracts AT command handling, automates network configuration, and supports protocols such as MQTT and Blynk. The architecture features a layered, hardware-agnostic core and device-specific adapters, enhancing portability and extensibility. The library includes structured exception handling and automated retries to improve system reliability. Empirical validation using a Raspberry Pi Pico and SIM7020E module in a typical IoT scenario demonstrated an up to 81% reduction in implementation time. By providing a reusable and extensible framework, this work improves developer productivity, enhances error resilience, and establishes a solid foundation for rapid NB-IoT application development. Future directions include cross-hardware validation and AI-assisted code and test generation.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25092745", "doi": "10.3390/s25092745", "title": "Extracting Daily Routines from Raw RSSI Data", "publicationYear": 2025, "publicationDate": "2025-04-26", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "9", "page": "2745", "issn": "1424-8220", "isbn": null, "authors": "Raúl Montoliu, Emilio Sansano-Sansano, Marina Martínez-García, Sergio Lluva-Plaza, Ana Jiménez-Martín, José M. Villadangos-Carrizo, Juan Jesús García-Domínguez", "authorCount": 7, "firstAuthorAffiliation": "Institute of New Imaging Technologies, Jaume I University, 12071 Castellón de la Plana, Spain", "isReferencedByCount": 0, "referenceCount": 12, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Agencia Estatal de Investigación (AEI), Fondo Europeo de Desarrollo Regional (FEDER)", "funderIds": null, "url": "https://doi.org/10.3390/s25092745", "pdfUrl": null, "abstract": "Detecting behavioral routines is an important research area with many implications in various practical applications. One such application involves studying the behavior of older adults residing in care homes. This paper proposes a comprehensive methodology for extracting and analyzing the daily routines of older adults in care homes. The methodology utilizes raw data comprising signal strength measurements obtained from smartwatches worn by six volunteers over five months. To establish the basis for estimating daily activities, fingerprint-based localization techniques are employed to track the minute-by-minute location of each volunteer. Subsequently, the activity performed by each volunteer is estimated for each day. Finally, the study estimates the probability of a user undertaking each one of the studied activities on a given weekday.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25133847", "doi": "10.3390/s25133847", "title": "Numerical Simulation of Streaming Discharge Characteristics of Free Metal Particles in SF6/CF4 Gas Mixtures Under Highly Heterogeneous Electric Field", "publicationYear": 2025, "publicationDate": "2025-06-20", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "13", "page": "3847", "issn": "1424-8220", "isbn": null, "authors": "Bing Qi, Hui Wang, Chang Liu, Fuyou Teng, Daoxin Yu, Yuxuan Liang, Feihu Wang", "authorCount": 7, "firstAuthorAffiliation": "Key Laboratory of Modern Power System Simulation and Control and Renewable Energy Technology, Ministry of Education, School of Electrical Engineering, Northeast Electric Power University, Jilin City 132012, China", "isReferencedByCount": 1, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Jilin Provincial Natural Science Foundation", "funderIds": "10.13039/100007847", "url": "https://doi.org/10.3390/s25133847", "pdfUrl": null, "abstract": "Compared to pure SF6 gas, the SF6/CF4 gas mixture exhibits certain advantages in reducing greenhouse effects, lowering the liquefaction temperature, and decreasing the sensitivity to non-uniform electric fields, demonstrating significant application potential in high-voltage electrical equipment. This study employs a two-dimensional plasma fluid model to investigate the partial discharge phenomena induced by free metallic particles in SF6/CF4 gas mixtures, analyzing the spatiotemporal evolution characteristics of key parameters, such as the charged particle density and axial electric field, under different mixing ratios. The simulation results show that there are two kinds of positive stream discharge phenomena, “continuous and decaying”, when the gas mixture ratio is 90%CF4-10%SF6 and 40%CF4-60%SF6. The proportion of CF4 in the gas mixture will affect the spatial distribution of charged particles and the production and disappearance of electrons. When the proportion of CF4 is 90%, the content of positive ions in the discharge channel is the highest, and the electric field formed by the positive space charge of CF4+ in the stream head promotes the continuous propagation of the stream. As the concentration of CF4 decreases, the main ionization reaction at the stream head shifts from CF4 to SF6, and a negative space charge region dominated by SF6− particles is also formed near the stream head, changing the electric field distribution near the flow head. The adhesion reaction rate is greater than the ionization reaction rate, resulting in the disappearance of electrons greater than the production, and the stream phenomenon tends to decay. These simulation results are helpful to understand the dynamic process of positive stream discharge induced by free metal particles in SF6/CF4 gas mixtures, and they provide a theoretical basis for better solutions to equipment damage caused by partial discharge.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25123763", "doi": "10.3390/s25123763", "title": "Impact Evaluation of DME Beacons on BeiDou B2a Signal Reception Performance", "publicationYear": 2025, "publicationDate": "2025-06-16", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "12", "page": "3763", "issn": "1424-8220", "isbn": null, "authors": "Yicheng Li, Jinli Cui, Zhenyang Ma, Zhaobin Duan", "authorCount": 4, "firstAuthorAffiliation": "Key Laboratory of Civil Aviation Aircraft Airworthiness Certification Technology, Civil Aviation University of China, Tianjin 300300, China", "isReferencedByCount": 0, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Civil Aviation Administration of China", "funderIds": null, "url": "https://doi.org/10.3390/s25123763", "pdfUrl": null, "abstract": "The operational integrity of the BeiDou-3 Navigation Satellite System (BDS-3) has been significantly challenged by electromagnetic interference, particularly from Distance Measuring Equipment (DME) ground beacons to the newly implemented B2a signal, since its full operational deployment in 2020. This study developed a comprehensive interference evaluation model based on receiver signal processing principles to quantify the degradation of B2a signal reception performance under DME interference scenarios. Leveraging empirical data from the DME beacon network in the Chinese mainland, we systematically analyzed the interference effects through an effective carrier-to-noise ratio (C/N0), signal detection probability, carrier tracking accuracy, and demodulation bit error rate (BER). The results demonstrate that the effective C/N0 of the B2a signal degrades by up to 3.25 dB, the detection probability decreases by 33%, and the carrier tracking errors and BER increase by 2.57° and 5.1%, respectively, in worst-case interference scenarios. Furthermore, significant spatial correlation was observed between the interference hotspots and regions of high aircraft density. DME interference adversely affected the accuracy, availability, continuity, and integrity of the airborne BeiDou navigation system, thereby compromising civil aviation flight safety. These findings establish a scientific foundation for developing Minimum Operational Performance Standards for B2a signal receivers and for strategically optimizing DME beacon deployment throughout the Chinese mainland.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25030981", "doi": "10.3390/s25030981", "title": "A 60 GHz Class-C Wide Tuning-Range Two-Core VCO Utilizing a Gain-Boosting Frequency Doubling Technique and an Adaptive Bias Scheme for Robust Startup", "publicationYear": 2025, "publicationDate": "2025-02-06", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "3", "page": "981", "issn": "1424-8220", "isbn": null, "authors": "Ioannis Dimitrios Psycharis, Vasileios Tsourtis, Grigorios Kalivas", "authorCount": 3, "firstAuthorAffiliation": "Department of Electrical and Computer Engineering, University of Patras, 265 04 Patras, Greece", "isReferencedByCount": 1, "referenceCount": 37, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Union and the Greek General Secretariat of Research and Technology", "funderIds": null, "url": "https://doi.org/10.3390/s25030981", "pdfUrl": null, "abstract": "This paper presents the design and the performance of a wide tuning-range millimeter-wave (mm-wave) two-core class-C 60 GHz VCO in 40 nm CMOS process, which can be integrated into wireless communication transceivers and radar sensors. The proposed architecture consists of a two-core 30 GHz fundamental VCO, a gain-boosted frequency doubler and an adaptive bias configuration. The two-core fundamental VCO structure achieves frequency generation in the vicinity of 30 GHz, where each VCO core targets a different frequency band. The two bands have sufficient overlap to accommodate for corner variations providing a large continuous tuning range. The desired frequency band is selected by activating or deactivating the appropriate VCO core, resulting in a robust switchless structure. This approach enables a considerably broad tuning range without compromising phase noise performance. Furthermore, the proposed topology utilizes an adaptive bias mechanism for robust start-up. Initially, the selected VCO core begins oscillating in class-B mode, and subsequently it transitions into class-C operation to offer improved performance. From post-layout simulations, after frequency doubling, the low-band VCO covers frequencies from 50.25 to 60.40 GHz, while the high-band VCO core spans frequencies from 58.8 to 73 GHz, yielding an overall tuning range of 36.92%. Owing to the gain-boosting topology, output power exceeds −14.2 dBm across the whole bandwidth. Simulated phase noise remains better than −92.1 dBc/Hz at a 1 MHz offset for all bands. Additionally, the two VCO cores never operate simultaneously, aiding in power efficiency.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25061899", "doi": "10.3390/s25061899", "title": "Hybrid Dual-Link Data Transmission Based on Internet of Vessels", "publicationYear": 2025, "publicationDate": "2025-03-18", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "6", "page": "1899", "issn": "1424-8220", "isbn": null, "authors": "Fei Li, Ying Guo, Ziqi Wang, Yuhang Chen, Jingyun Gu", "authorCount": 5, "firstAuthorAffiliation": "College of Information Science and Technology, Qingdao University of Science and Technology, Qingdao 266061, China", "isReferencedByCount": 1, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Key Research and Development Program of China", "funderIds": null, "url": "https://doi.org/10.3390/s25061899", "pdfUrl": null, "abstract": "The transmission of marine data is an urgent global challenge. Due to the particularity of underwater environments, the efficiency and reliability of data transmission in underwater acoustic communication are severely restricted, especially in long-distance and large-scale data transmission situations. This study proposes a dual-link data transmission method based on the Internet of Vessels, utilizing the powerful communication capabilities and flexibility of ships as relay nodes for data transmission. By constructing both above-water and underwater dual-link collaborative transmission, the method effectively improves data transmission rates and stability. Additionally, a spatial crowdsourcing allocation algorithm based on Bayesian reputation selection is designed to assess the capability of ships to complete tasks, and an integrated scoring function is used to select the optimal relay ship, solving the problems of relay ship selection and transmission path selection in the data transmission process. Furthermore, this study introduces an incentive mechanism for data transmission based on the Internet of Vessels, which maximizes the stability of data transmission. Experimental results show that the dual-link data transmission method of the Internet of Vessels significantly improves the reliability and transmission speed of underwater communication, providing a novel and practical solution for long-distance, large-volume data transmission in maritime environments.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25092684", "doi": "10.3390/s25092684", "title": "Enhanced Cloud Detection Using a Unified Multimodal Data Fusion Approach in Remote Images", "publicationYear": 2025, "publicationDate": "2025-04-24", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "9", "page": "2684", "issn": "1424-8220", "isbn": null, "authors": "Yan Mo, Puhui Chen, Wanting Zhou, Wei Chen", "authorCount": 4, "firstAuthorAffiliation": "College of Aeronautics Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China", "isReferencedByCount": 1, "referenceCount": 57, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Natural Science Foundation of China", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.3390/s25092684", "pdfUrl": null, "abstract": "Aiming at the complexity of network architecture design and the low computational efficiency caused by variations in the number of modalities in multimodal cloud detection tasks, this paper proposes an efficient and unified multimodal cloud detection model, M2Cloud, which can process any number of modal data. The core innovation of M2Cloud lies in its novel multimodal data fusion method. This method avoids architectural changes for new modalities, thereby significantly reducing incremental computing costs and enhancing overall efficiency. Furthermore, the designed multimodal data fusion module possesses strong generalization capabilities and can be seamlessly integrated into other network architectures in a plug-and-play manner, greatly enhancing the module’s practicality and flexibility. To address the challenge of unified multimodal feature extraction, we adopt two key strategies: (1) constructing feature extraction modules with shared but independent weights for each modality to preserve the inherent features of each modality; (2) utilizing cosine similarity to adaptively learn complementary features between different modalities, thereby reducing redundant information. Experimental results demonstrate that M2Cloud achieves or even surpasses the state-of-the-art (SOTA) performance on the public multimodal datasets WHUS2-CD and WHUS2-CD+, verifying its effectiveness in the unified multimodal cloud detection task. The research presented in this paper offers new insights and technical support for the field of multimodal data fusion and cloud detection, and holds significant theoretical and practical value.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s25061646", "doi": "10.3390/s25061646", "title": "A Current Sensing Cross-Component Induction Magnetometer for Use in Time-Domain Borehole Geophysical Electromagnetic Surveys", "publicationYear": 2025, "publicationDate": "2025-03-07", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "25", "issue": "6", "page": "1646", "issn": "1424-8220", "isbn": null, "authors": "Joseph Hamad, James Macnae", "authorCount": 2, "firstAuthorAffiliation": "School of Applied Sciences, RMIT University, Melbourne 3001, Australia", "isReferencedByCount": 0, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "RMIT University, Abitibi Geophysics, Monex Geoscope", "funderIds": null, "url": "https://doi.org/10.3390/s25061646", "pdfUrl": null, "abstract": "Electromagnetic sensors are best defined by their linearity, signal sensitivity, and noise level. In borehole time-domain electromagnetics (TEM) the cross-components are defined as the two components perpendicular to the borehole’s axial direction. Induction sensors measuring voltage across an open coil for the cross-components have poor sensitivity, and fluxgate magnetometers have been a common band-limited alternative for borehole TEM surveys. In this research, we use a shorted coil with current rather than voltage sensing circuitry to produce a cross-component induction magnetometer (CCIM). With flux coupling and electronic adjustments, we achieved a low-cut corner frequency of 3.5 Hz in the final design of the CCIM. For the prototype sensor, we found the simple ratio of measured inductance L to winding resistance R to be a poor predictor of the −3 dB corner frequency, and a transfer function measurement was required. The cause of the discrepancy may be that the self-inductance measured by a meter is different from the coupling inductance to an external field. The measured noise level of our CCIM sensors was 125 pT/√Hz at 1 Hz, compared to a geometrically longer axial component sensor with 4 pT/√Hz at this frequency. However, our design matched the typical fluxgate noise level of 6 pT/√Hz at 10 Hz. Further, the CCIM sensors were superior to fluxgates at frequencies higher than 10 Hz, with an internal noise level of 0.1 pT/√Hz between 100 Hz and &gt;20 kHz. Induction coils or magnetometers measuring the cross-component are attractive because they have excellent high-frequency bandwidth and can be included in the same downhole package with fluxgate sensors.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s24020546", "doi": "10.3390/s24020546", "title": "Special Issue “Emerging AI+X-Based Sensor and Networking Technologies including Selected Papers from ICGHIT 2022–2023”", "publicationYear": 2024, "publicationDate": "2024-01-15", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "24", "issue": "2", "page": "546", "issn": "1424-8220", "isbn": null, "authors": "Byung-Seo Kim, Muhammad Khalil Afzal, Rehmat Ullah", "authorCount": 3, "firstAuthorAffiliation": "Department of Software and Communication Engineering, Hongik University, Sejong 30016, Republic of Korea", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s24020546", "pdfUrl": null, "abstract": "This Special Issue is a collection of selected papers from the 10th and 11th International Conferences on Green and Human Information Technology (ICGHITs) [...]", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s23198314", "doi": "10.3390/s23198314", "title": "The Frequency-Variable Rotor-Blade-Based Two-Degree-of-Freedom Actuation Principle for Linear and Rotary Motion", "publicationYear": 2023, "publicationDate": "2023-10-08", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "23", "issue": "19", "page": "8314", "issn": "1424-8220", "isbn": null, "authors": "Xiaotao Li, Shengjiang Wang, Xiangyou Peng, Guan Xu, Jingshi Dong, Fengjun Tian, Qiuyu Zhang", "authorCount": 7, "firstAuthorAffiliation": "School of Mechanical and Aerospace Engineering, Nanling Campus, Jilin University, Changchun 130025, China", "isReferencedByCount": 1, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Natural Science Foundation of China, Science and Technology Research Project of Education Department of Jilin Province", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.3390/s23198314", "pdfUrl": null, "abstract": "Piezoelectric accurate actuation plays an important role in industrial applications. The intrinsic frequency of previous actuators is invariable. However, variable frequency can approach the range near the low-intrinsic-frequency and realize a high actuation capability. The frequency-variable linear and rotary motion (FVLRM) principle is proposed for rotor-blade-based two-degree-of-freedom driving. Inertial force is generated by frequency-variable piezoelectric oscillators (FVPO), the base frequency and vibration modes of which are adjustable by the changeable mass and position of the mass block. The variable-frequency principle of FVPO and the FVLRM are recognized and verified by the simulations and experiments, respectively. The experiments show that the FVLRM prototype moves the fastest when the mass block is placed at the farthest position and the prototype is at the second-order intrinsic frequencies of 42 Hz and 43 Hz, achieving a linear motion of 3.52 mm/s and a rotary motion of 286.9 mrad/s. The actuator adopts a lower operating frequency of less than 60 Hz and has the function of adjusting the natural frequency. It can achieve linear and rotational motion with a larger working stroke with 140 mm linear movement and 360° rotation.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s23073605", "doi": "10.3390/s23073605", "title": "BICM-ID Labeling-Based Recipient Identification in a Heterogeneous Network", "publicationYear": 2023, "publicationDate": "2023-03-30", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "23", "issue": "7", "page": "3605", "issn": "1424-8220", "isbn": null, "authors": "Maciej Krasicki", "authorCount": 1, "firstAuthorAffiliation": "Faculty of Computing and Telecommunications, Institute of Radiocommunications, Poznan University of Technology, Polanka 3, 61-131 Poznan, Poland", "isReferencedByCount": 2, "referenceCount": 19, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Polish Ministry of Education and Science", "funderIds": null, "url": "https://doi.org/10.3390/s23073605", "pdfUrl": null, "abstract": "The concept of labeling-based recipient identification (LABRID) for bit-interleaved coded modulation with iterative decoding (BICM-ID) is revisited. LABRID allows addressing a message recipient station in a wireless network by using an individual labeling map without compromising error performance. This eliminates the need to use any byte of the data frame to carry the recipient address explicitly. In addition, the destination of the frame can be determined in parallel with a BICM-ID decoding procedure in the receiver’s physical layer. Therefore, the MAC layer is not involved in processing the vast majority of frames transmitted in a network. Previously, it was shown that LABRID works fine if there are only LABRID-compatible stations within the network, and every receiver can reject frames destined for other receivers. This paper considers a scenario in which LABRID-compatible BICM-ID stations and legacy BICM stations coexist in the same network. A few experiments show that the LABRID receiver can reject an old-fashioned BICM frame by judging the convergence of the iterative decoding process. It also turns out that the legacy BICM receiver can identify and dismiss the LABRID-type frames thanks to the standard cyclic redundancy check (CRC) procedure.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s23052728", "doi": "10.3390/s23052728", "title": "Feasibility Study on the Discrimination of Fluor Concentration in the Liquid Scintillator Using PMT Waveform and Short-Pass Filter", "publicationYear": 2023, "publicationDate": "2023-03-02", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "23", "issue": "5", "page": "2728", "issn": "1424-8220", "isbn": null, "authors": "Na-Ri Kim, Kyung-Kwang Joo, Hyun-Gi Lee", "authorCount": 3, "firstAuthorAffiliation": "Center for Precision Neutrino Research, Department of Physics, Chonnam National University, Yongbong-ro 77, Puk-gu, Gwangju 61186, Republic of Korea", "isReferencedByCount": 2, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Research Foundation (NRF) of the Korean government", "funderIds": null, "url": "https://doi.org/10.3390/s23052728", "pdfUrl": null, "abstract": "Neutrinos are difficult to detect because they weakly interact with matter, making their properties least known. The response of the neutrino detector depends on the optical properties of the liquid scintillator (LS). Monitoring any characteristic changes in the LS helps to understand the temporal variation of detector response. In this study, a detector filled with LS was used to study the characteristics of the neutrinos detector. We investigated a method to distinguish the concentrations of PPO and bis-MSB, which are fluors added to LS, through a photomultiplier tube (PMT) acting as an optical sensor. Conventionally, it is very challenging to discriminate the flour concentration dissolved in LS. We employed the information of pulse shape and PMT coupled with the short-pass filter. To date, no literature report on a measurement using such an experimental setup has been published. As the concentration of PPO was increased, changes in the pulse shape were observed. In addition, as the concentration of bis-MSB was increased, a decrease in the light yield was observed in the PMT equipped with the short-pass filter. This result suggests the feasibility of real-time monitoring of LS properties, which are correlated with the fluor concentration, using a PMT without extracting the LS samples from the detector during the data acquisition process.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s23052763", "doi": "10.3390/s23052763", "title": "A Novel Method for Automatic Detection and Elimination of the Jumps Caused by the Instantaneous Disturbance Torque in the Maglev Gyro Signal", "publicationYear": 2023, "publicationDate": "2023-03-02", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "23", "issue": "5", "page": "2763", "issn": "1424-8220", "isbn": null, "authors": "Yiwen Wang, Zhiqiang Yang, Ji Ma, Zhen Shi, Di Liu, Ling Shi, Hang Li", "authorCount": 7, "firstAuthorAffiliation": "School of Geology Engineering and Geomatics, Chang’an University, 126 Yanta Road, Xi’an 710054, China", "isReferencedByCount": 2, "referenceCount": 40, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Natural Science Foundation of China, Natural Science Basic Research Program of Shaanxi, Fundamental Research Funds for the Central Universities, CHD, Key Laboratory of Geospace Environment and Geodesy, Ministry of Education, Wuhan University, Guangxi Young and Middle-aged Teachers’ Basic Scientific Research Ability Improvement Project, Natural Science Foundation of Guangxi", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.3390/s23052763", "pdfUrl": null, "abstract": "The signal measured by the maglev gyro sensor is sensitive to the influence of the instantaneous disturbance torque caused by the instantaneous strong wind or the ground vibration, which reduced the north-seeking accuracy of the instrument. To address this issue, we proposed a novel method combining the heuristic segmentation algorithm (HSA) and the two-sample Kolmogorov-Smirnov (KS) test (named HSA-KS method) to process the gyro signals and improve the north-seeking accuracy of the gyro. There were two key steps in the HSA-KS method: (i) all the potential change points were automatically and accurately detected by HSA, and (ii) the jumps in the signal caused by the instantaneous disturbance torque were quickly located and eliminated by the two-sample KS test. The effectiveness of our method was verified through a field experiment on a high-precision global positioning system (GPS) baseline at the 5th sub-tunnel of the Qinling water conveyance tunnel of the Hanjiang-to-Weihe River Diversion Project in Shaanxi Province, China. Our results from the autocorrelograms indicated that the jumps in the gyro signals can be automatically and accurately eliminated by the HSA-KS method. After processing, the absolute difference between the gyro and high-precision GPS north azimuths was enhanced by 53.5%, which was superior to the optimized wavelet transform and the optimized Hilbert-Huang transform.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s23052529", "doi": "10.3390/s23052529", "title": "Joint Video Super-Resolution and Frame Interpolation via Permutation Invariance", "publicationYear": 2023, "publicationDate": "2023-02-24", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "23", "issue": "5", "page": "2529", "issn": "1424-8220", "isbn": null, "authors": "Jinsoo Choi, Tae-Hyun Oh", "authorCount": 2, "firstAuthorAffiliation": "Department of Electrical Engineering, KAIST, Daejeon 34141, Republic of Korea", "isReferencedByCount": 3, "referenceCount": 47, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT), Institute of Information &amp; communications Technology Planning &amp; Evaluation (IITP) grant funded by the Korea government (MSIT), National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)", "funderIds": null, "url": "https://doi.org/10.3390/s23052529", "pdfUrl": null, "abstract": "We propose a joint super resolution (SR) and frame interpolation framework that can perform both spatial and temporal super resolution. We identify performance variation according to permutation of inputs in video super-resolution and video frame interpolation. We postulate that favorable features extracted from multiple frames should be consistent regardless of input order if the features are optimally complementary for respective frames. With this motivation, we propose a permutation invariant deep architecture that makes use of the multi-frame SR principles by virtue of our order (permutation) invariant network. Specifically, given two adjacent frames, our model employs a permutation invariant convolutional neural network module to extract “complementary” feature representations facilitating both the SR and temporal interpolation tasks. We demonstrate the effectiveness of our end-to-end joint method against various combinations of the competing SR and frame interpolation methods on challenging video datasets, and thereby we verify our hypothesis.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s23031640", "doi": "10.3390/s23031640", "title": "Editorial for the Special Issue on Electronics for Sensors II", "publicationYear": 2023, "publicationDate": "2023-02-02", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "23", "issue": "3", "page": "1640", "issn": "1424-8220", "isbn": null, "authors": "Giuseppe Ferri, Gianluca Barile, Alfiero Leoni", "authorCount": 3, "firstAuthorAffiliation": "Department of Industrial and Information Engineering and Economics, University of L’Aquila, 67100 L’Aquila, Italy", "isReferencedByCount": 0, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s23031640", "pdfUrl": null, "abstract": "Sensor signals are physical, chemical, or biological quantities that evolve over time [...]", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s20061605", "doi": "10.3390/s20061605", "title": "Erratum: Han, D.-H.; Kang, L.-H. Terahertz Displacement and Thickness Sensor with Micrometer Resolution and Centimeter Dynamic Range", "publicationYear": 2020, "publicationDate": "2020-03-13", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "20", "issue": "6", "page": "1605", "issn": "1424-8220", "isbn": null, "authors": "Dae-Hyun Han, Lae-Hyong Kang", "authorCount": 2, "firstAuthorAffiliation": "Department of Mechatronics Engineering, and LANL-JBNU Engineering Institute-Korea, Jeonbuk National University, 567 Baekje-daero, Duckjin-gu, Jeonju-si, Jeonbuk 54896, Korea", "isReferencedByCount": 0, "referenceCount": 1, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s20061605", "pdfUrl": null, "abstract": "The authors wish to make the following erratum to this paper [...]", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s16091368", "doi": "10.3390/s16091368", "title": "Tracking Control of a Magnetic Shape Memory Actuator Using an Inverse Preisach Model with Modified Fuzzy Sliding Mode Control", "publicationYear": 2016, "publicationDate": "2016-08-25", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "16", "issue": "9", "page": "1368", "issn": "1424-8220", "isbn": null, "authors": "Jhih-Hong Lin, Mao-Hsiung Chiang", "authorCount": 2, "firstAuthorAffiliation": "Department of Engineering Science and Ocean Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 106, Taiwan", "isReferencedByCount": 10, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Ministry of Science and Technology, Taiwan", "funderIds": "10.13039/501100004663", "url": "https://doi.org/10.3390/s16091368", "pdfUrl": null, "abstract": "Magnetic shape memory (MSM) alloys are a new class of smart materials with extraordinary strains up to 12% and frequencies in the range of 1 to 2 kHz. The MSM actuator is a potential device which can achieve high performance electromagnetic actuation by using the properties of MSM alloys. However, significant non-linear hysteresis behavior is a significant barrier to control the MSM actuator. In this paper, the Preisach model was used, by capturing experiments from different input signals and output responses, to model the hysteresis of MSM actuator, and the inverse Preisach model, as a feedforward control, provided compensational signals to the MSM actuator to linearize the hysteresis non-linearity. The control strategy for path tracking combined the hysteresis compensator and the modified fuzzy sliding mode control (MFSMC) which served as a path controller. Based on the experimental results, it was verified that a tracking error in the order of micrometers was achieved.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.3390/s150715265", "doi": "10.3390/s150715265", "title": "Coded Cooperation for Multiway Relaying in Wireless Sensor Networks", "publicationYear": 2015, "publicationDate": "2015-06-29", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sensors", "volume": "15", "issue": "7", "page": "15265-15284", "issn": "1424-8220", "isbn": null, "authors": "Zhongwei Si, Junyang Ma, Ragnar Thobaben", "authorCount": 3, "firstAuthorAffiliation": "Key Lab of Universal Wireless Communications, Ministry of Education, Beijing University of Posts and Telecommunications (BUPT), 100876 Beijing, China", "isReferencedByCount": 1, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3390/s150715265", "pdfUrl": null, "abstract": "Wireless sensor networks have been considered as an enabling technology for constructing smart cities. One important feature of wireless sensor networks is that the sensor nodes collaborate in some manner for communications. In this manuscript, we focus on the model of multiway relaying with full data exchange where each user wants to transmit and receive data to and from all other users in the network. We derive the capacity region for this specific model and propose a coding strategy through coset encoding. To obtain good performance with practical codes, we choose spatially-coupled LDPC (SC-LDPC) codes for the coded cooperation. In particular, for the message broadcasting from the relay, we construct multi-edge-type (MET) SC-LDPC codes by repeatedly applying coset encoding. Due to the capacity-achieving property of the SC-LDPC codes, we prove that the capacity region can theoretically be achieved by the proposed MET SC-LDPC codes. Numerical results with finite node degrees are provided, which show that the achievable rates approach the boundary of the capacity region in both binary erasure channels and additive white Gaussian channels.", "subject": null, "language": "en", "_run_id": "kl6owJEWuJjQFCc87", "_dataset_id": "lOLCXUSy1sxA91f0z"}
{"paperId": "10.1109/sp40001.2021.00011", "doi": "10.1109/sp40001.2021.00011", "title": "Systematic Analysis of Randomization-based Protected Cache Architectures", "publicationYear": 2021, "publicationDate": "2021-05", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2021 IEEE Symposium on Security and Privacy (SP)", "volume": null, "issue": null, "page": "987-1002", "issn": null, "isbn": null, "authors": "Antoon Purnal, Lukas Giner, Daniel Gruss, Ingrid Verbauwhede", "authorCount": 4, "firstAuthorAffiliation": "KU Leuven,Imec-COSIC", "isReferencedByCount": 57, "referenceCount": 58, "isOpenAccess": true, "licenseUrl": "https://doi.org/10.15223/policy-009", "funderNames": "European Research Council, KU Leuven", "funderIds": "10.13039/501100000781, 10.13039/501100004040", "url": "https://doi.org/10.1109/sp40001.2021.00011", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1145/3406325.3451062", "doi": "10.1145/3406325.3451062", "title": "Stronger bounds for weak epsilon-nets in higher dimensions", "publicationYear": 2021, "publicationDate": "2021-06-15", "type": "proceedings-article", "publisher": "ACM", "containerTitle": "Proceedings of the 53rd Annual ACM SIGACT Symposium on Theory of Computing", "volume": null, "issue": null, "page": "989-1002", "issn": null, "isbn": null, "authors": "Natan Rubin", "authorCount": 1, "firstAuthorAffiliation": "Ben-Gurion University of the Negev, Israel", "isReferencedByCount": 5, "referenceCount": 49, "isOpenAccess": true, "licenseUrl": "https://www.acm.org/publications/policies/copyright_policy#Background", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.1145/3406325.3451062", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1016/j.physrep.2022.12.002", "doi": "10.1016/j.physrep.2022.12.002", "title": "The critical O(N) CFT: Methods and conformal data", "publicationYear": 2023, "publicationDate": "2023-02", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Physics Reports", "volume": "1002", "issue": null, "page": "1-72", "issn": "0370-1573", "isbn": null, "authors": "Johan Henriksson", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 66, "referenceCount": 346, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "European Research Council, European Research Council, Horizon 2020 Framework Programme, Horizon 2020", "funderIds": "10.13039/100010663, 10.13039/501100000781, 10.13039/100010661, 10.13039/501100007601", "url": "https://doi.org/10.1016/j.physrep.2022.12.002", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1017/jfm.2024.1197", "doi": "10.1017/jfm.2024.1197", "title": "Turbulent shear flow without vortex shedding, Reynolds shear stress and small-scale intermittency", "publicationYear": 2025, "publicationDate": "2025-01-10", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Journal of Fluid Mechanics", "volume": "1002", "issue": null, "page": null, "issn": "0022-1120, 1469-7645", "isbn": null, "authors": "K. Steiros, M. Obligado, P. Bragança, C. Cuvier, J.C. Vassilicos", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 8, "referenceCount": 53, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.1017/jfm.2024.1197", "pdfUrl": null, "abstract": "This work presents an experimental investigation of the effects of vortex shedding suppression on the properties and recovery of turbulent wakes. Four plates, properly modified so that they produce different vortex shedding strengths, are tested using high speed particle image velocimetry and hot-wire anemometry, and analysed using spectral proper orthogonal decomposition, mean-flow linear stability analysis and various turbulence statistics. When present, vortex shedding is found to exhibit a characteristic frequency that scales with the mean shear, providing a link between the mean flow and the main turbulent motion. To achieve full suppression of shedding, we combine the effects of porosity and fractal perimeter. The mean shear is then decreased to the point where the flow becomes convectively unstable and shedding vanishes. In that case, the onset of self-similarity is delayed, compared with the case with vortex shedding, and appears after another large-scale structure, the secondary vortex street, emerges. It is also found that both large- and small-scale intermittency are starkly reduced when shedding is absent. A simple theoretical representation of the wake dynamics explains the evolution of the wake properties and its connection to the coherent structures in the flow.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.3390/genes12040487", "doi": "10.3390/genes12040487", "title": "Evolution of Multicellular Complexity in The Dictyostelid Social Amoebas", "publicationYear": 2021, "publicationDate": "2021-03-27", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Genes", "volume": "12", "issue": "4", "page": "487", "issn": "2073-4425", "isbn": null, "authors": "Koryu Kin, Pauline Schaap", "authorCount": 2, "firstAuthorAffiliation": "School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK", "isReferencedByCount": 25, "referenceCount": 122, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council, Wellcome Trust, European Molecular Biology Organization, Japanese Organisation for the Promotion of Science", "funderIds": "10.13039/501100000781, 10.13039/100010269, 10.13039/100004410", "url": "https://doi.org/10.3390/genes12040487", "pdfUrl": null, "abstract": "Multicellularity evolved repeatedly in the history of life, but how it unfolded varies greatly between different lineages. Dictyostelid social amoebas offer a good system to study the evolution of multicellular complexity, with a well-resolved phylogeny and molecular genetic tools being available. We compare the life cycles of the Dictyostelids with closely related amoebozoans to show that complex life cycles were already present in the unicellular common ancestor of Dictyostelids. We propose frost resistance as an early driver of multicellular evolution in Dictyostelids and show that the cell signalling pathways for differentiating spore and stalk cells evolved from that for encystation. The stalk cell differentiation program was further modified, possibly through gene duplication, to evolve a new cell type, cup cells, in Group 4 Dictyostelids. Studies in various multicellular organisms, including Dictyostelids, volvocine algae, and metazoans, suggest as a common principle in the evolution of multicellular complexity that unicellular regulatory programs for adapting to environmental change serve as “proto-cell types” for subsequent evolution of multicellular organisms. Later, new cell types could further evolve by duplicating and diversifying the “proto-cell type” gene regulatory networks.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1145/3514221.3526188", "doi": "10.1145/3514221.3526188", "title": "X-SSD: A Storage System with Native Support for Database Logging and Replication", "publicationYear": 2022, "publicationDate": "2022-06-10", "type": "proceedings-article", "publisher": "ACM", "containerTitle": "Proceedings of the 2022 International Conference on Management of Data", "volume": null, "issue": null, "page": "988-1002", "issn": null, "isbn": null, "authors": "Sangjin Lee, Alberto Lerner, André Ryser, Kibin Park, Chanyoung Jeon, Jinsub Park, Yong Ho Song, Philippe Cudré-Mauroux", "authorCount": 8, "firstAuthorAffiliation": "Hanyang University, Seoul, Republic of Korea", "isReferencedByCount": 19, "referenceCount": 78, "isOpenAccess": true, "licenseUrl": "https://www.acm.org/publications/policies/copyright_policy#Background", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.1145/3514221.3526188", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1523/jneurosci.1002-20.2021", "doi": "10.1523/jneurosci.1002-20.2021", "title": "Disrupting Epileptiform Activity by Preventing Parvalbumin Interneuron Depolarization Block", "publicationYear": 2021, "publicationDate": "2021-11-10", "type": "journal-article", "publisher": "Society for Neuroscience", "containerTitle": "The Journal of Neuroscience", "volume": "41", "issue": "45", "page": "9452-9465", "issn": "0270-6474, 1529-2401", "isbn": null, "authors": "Alexandru Călin, Andrei S. Ilie, Colin J. Akerman", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 63, "referenceCount": 58, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-sa/4.0/", "funderNames": "Wellcome Trust, EC | European Research Council, EC | European Research Council, University College Oxford", "funderIds": "10.13039/100010269, 10.13039/501100000781, 10.13039/501100000781, 10.13039/501100000734", "url": "https://doi.org/10.1523/jneurosci.1002-20.2021", "pdfUrl": null, "abstract": "Inhibitory synaptic mechanisms oppose epileptic network activity in the brain. The breakdown in this inhibitory restraint and propagation of seizure activity has been linked to the overwhelming of feedforward inhibition, which is provided in large part by parvalbumin-expressing (PV) interneurons in the cortex. The underlying cellular processes therefore represent potential targets for understanding and preventing the propagation of seizure activity. Here we use an optogenetic strategy to test the hypothesis that depolarization block in PV interneurons is a significant factor during the loss of inhibitory restraint. Depolarization block results from the inactivation of voltage-gated sodium channels and leads to impaired action potential firing. We used focal NMDA stimulation to elicit reproducible epileptiform discharges in hippocampal organotypic brain slices from male and female mice and combined this with targeted recordings from defined neuronal populations. Simultaneous patch-clamp recordings from PV interneurons and pyramidal neurons revealed epileptiform activity that was associated with an overwhelming of inhibitory synaptic mechanisms and the emergence of a partial, and then complete, depolarization block in PV interneurons. To counteract this depolarization block, we developed protocols for eliciting pulsed membrane hyperpolarization via the inhibitory opsin, archaerhodopsin. This optical approach was effective in counteracting cumulative inactivation of voltage-gated channels, maintaining PV interneuron action potential firing properties during the inhibitory restraint period, and reducing the probability of initiating epileptiform activity. These experiments support the idea that depolarization block is a point of weakness in feedforward inhibitory synaptic mechanisms and represents a target for preventing the initiation and spread of seizure activity.SIGNIFICANCE STATEMENTGABAAreceptor-mediated synaptic transmission opposes seizure activity by establishing an inhibitory restraint against spreading excitation. Parvalbumin-expressing (PV) interneurons contribute significantly to this inhibitory restraint, but it has been suggested that these cells are overwhelmed as they enter a state of “depolarization block.” Here we test the importance of this process by devising an optogenetic strategy to selectively relieve depolarization block in PV interneurons. By inducing brief membrane hyperpolarization, we show that it is possible to reduce depolarization block in PV interneurons, maintain their action potential firing in the face of strong excitation, and disrupt epileptiform activity in anin vitromodel. This represents a proof of principle that targeting rate-limiting processes can strengthen the inhibitory restraint of epileptiform activity.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1210/clinem/dgac100", "doi": "10.1210/clinem/dgac100", "title": "Effect of AZD4017, a Selective 11β-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia", "publicationYear": 2022, "publicationDate": "2022-06-16", "type": "journal-article", "publisher": "The Endocrine Society", "containerTitle": "The Journal of Clinical Endocrinology &amp; Metabolism", "volume": "107", "issue": "7", "page": "2026-2035", "issn": "0021-972X, 1945-7197", "isbn": null, "authors": "Afroze Abbas, Marian Schini, Gemma Ainsworth, Sarah R Brown, Jamie Oughton, Rachel K Crowley, Mark S Cooper, Rebecca J Fairclough, Richard Eastell, Paul M Stewart", "authorCount": 10, "firstAuthorAffiliation": "Faculty of Medicine and Health, University of Leeds, and Leeds Teaching Hospitals NHS Trust , Leeds LS9 7TF , UK", "isReferencedByCount": 9, "referenceCount": 28, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Medical Research Council, European Research Council, NIHR, NIHR", "funderIds": "10.13039/501100000265, 10.13039/501100000781, 10.13039/501100000272, 10.13039/501100000272", "url": "https://doi.org/10.1210/clinem/dgac100", "pdfUrl": "https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgac100/42900112/dgac100.pdf", "abstract": "Abstract Context The causative link between circulating glucocorticoid excess and osteoporosis is well-established. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which increases local cortisol production, is expressed in human osteoblasts and its activity increases with age. Objective We hypothesized that local 11β-HSD1 might mediate an age-related decrease in bone formation and that selective 11β-HSD1 inhibition may enhance bone formation. Methods A dual-center, phase II, randomized, double-blind, placebo-controlled trial of 90 days’ treatment with AZD4017 (a selective 11β-HSD1 inhibitor) was conducted in 55 postmenopausal women with osteopenia. Participants received 400 mg oral AZD4017 twice daily vs matched placebo over 90 days. The primary outcome measure was the impact on the bone formation marker osteocalcin. Secondary objectives included correlation with 11β-HSD1 activity. Results At 90 days, osteocalcin levels did not differ between treatment groups: active (mean 22.3 [SD 8.6] ng/mL, n = 22) and placebo (21.7 [SD 9.2] ng/mL, n = 24), with a baseline-adjusted treatment effect of 0.95 (95% CI: −2.69, 4.60). The results from the urinary [THF + alloTHF]/THE ratio (index of 11β-HSD1 activity) and the urinary cortisol/cortisone ratio (index of 11β-HSD2 activity) confirmed a &amp;gt; 90% inhibition of 11β-HSD1 but no change in activity of 11β-HSD2. Conclusion This trial demonstrates that AZD4017 selectively inhibits 11β-HSD1 activity in vivo in a safe and reversible manner. Following 90 days of treatment, there is no effect on bone formation, indicating that the relative impairment of bone mineral density in postmenopausal women is not mediated by local intracellular production of cortisol under normal physiological concentrations.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1016/j.cellsig.2023.110714", "doi": "10.1016/j.cellsig.2023.110714", "title": "The protein kinases of Dictyostelia and their incorporation into a signalome", "publicationYear": 2023, "publicationDate": "2023-08", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cellular Signalling", "volume": "108", "issue": null, "page": "110714", "issn": "0898-6568", "isbn": null, "authors": "Koryu Kin, Zhi-hui Chen, Gillian Forbes, Hajara Lawal, Christina Schilde, Reema Singh, Christian Cole, Geoffrey J. Barton, Pauline Schaap", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 76, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "European Molecular Biology Organization, Wellcome Trust, Wellcome Trust, European Research Council, Biotechnology and Biological Sciences Research Council, Japan Society for the Promotion of Science London, European Research Council", "funderIds": "10.13039/100004410, 10.13039/100010269, 10.13039/100010269, 10.13039/100010663, 10.13039/501100000268, 10.13039/501100000646, 10.13039/501100000781", "url": "https://doi.org/10.1016/j.cellsig.2023.110714", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1016/j.pedsph.2024.08.009", "doi": "10.1016/j.pedsph.2024.08.009", "title": "Soil microbial carbon consumption is affected by tree and mammal diversity", "publicationYear": 2025, "publicationDate": "2025-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Pedosphere", "volume": "35", "issue": "6", "page": "945-956", "issn": "1002-0160", "isbn": null, "authors": "María LOSADA, Mar SOBRAL, Antonio M. MARTÍNEZ CORTIZAS, Carlos E.P. CERRI, Kristen M. DEANGELIS, Sara VARELA, José M.V. FRAGOSO, Kirsten M. SILVIUS", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 116, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Xunta de Galicia, Xunta de Galicia, Xunta de Galicia, European Research Council, Gordon and Betty Moore Foundation, National Science Foundation, Stanford University, Universidade de Santiago de Compostela", "funderIds": "10.13039/501100010801, 10.13039/501100010801, 10.13039/501100010801, 10.13039/501100000781, 10.13039/100000936, 10.13039/100000001, 10.13039/100005492, 10.13039/501100015068", "url": "https://doi.org/10.1016/j.pedsph.2024.08.009", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1103/lkvl-dlcn", "doi": "10.1103/lkvl-dlcn", "title": "Chaos, coherence, and turbulence", "publicationYear": 2025, "publicationDate": "2025-10-27", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Physical Review Fluids", "volume": "10", "issue": "10", "page": null, "issn": "2469-990X", "isbn": null, "authors": "Javier Jiménez", "authorCount": 1, "firstAuthorAffiliation": "Universidad Politécnica de Madrid", "isReferencedByCount": 5, "referenceCount": 127, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.1103/lkvl-dlcn", "pdfUrl": null, "abstract": "This paper is a personal overview of the efforts over the past half century to understand fluid turbulence in terms of simpler coherent units. The consequences of chaos and the concept of coherence are first reviewed, using examples from free-shear and wall-bounded shear flows, and including how the simplifications due to coherent structures have been useful in the conceptualization and control of turbulence. It is remarked that, even if this approach has revolutionized our understanding of the flow, most of turbulence cannot yet be described by structures. This includes cascades, both direct and inverse, and possibly junk turbulence, whose role, if any, is currently unknown. This part of the paper is mostly a catalog of questions, some of them answered and others still open. A second part of the paper examines which new techniques can be expected to help in attacking the open questions and which, in the opinion of the author, are the strengths and limitations of current approaches, such as data-driven science and causal inference.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1016/j.tplants.2025.06.001", "doi": "10.1016/j.tplants.2025.06.001", "title": "The chemical interaction between plants and the rhizosphere microbiome", "publicationYear": 2025, "publicationDate": "2025-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Trends in Plant Science", "volume": "30", "issue": "9", "page": "1002-1019", "issn": "1360-1385", "isbn": null, "authors": "Harro Bouwmeester, Lemeng Dong, Kathrin Wippel, Twan Hofland, Age Smilde", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 45, "referenceCount": 140, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Deutsche Forschungsgemeinschaft, Deutsche Forschungsgemeinschaft, Technology Foundation STW, HORIZON EUROPE European Research Council, European Research Council, University of Amsterdam, EU Framework Programme for Research and Innovation Marie Skłodowska-Curie Actions, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Toegepaste en Technische Wetenschappen, NWO, European Research Council", "funderIds": "10.13039/501100001659, 10.13039/501100001659, 10.13039/501100003958, 10.13039/100019180, 10.13039/100010663, 10.13039/501100001827, 10.13039/100010665, 10.13039/501100003246, 10.13039/501100003246, 10.13039/501100024872, 10.13039/501100000781", "url": "https://doi.org/10.1016/j.tplants.2025.06.001", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.15252/embr.202051635", "doi": "10.15252/embr.202051635", "title": "Monitoring mitochondrial translation in living cells", "publicationYear": 2021, "publicationDate": "2021-04-07", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "The EMBO Reports", "volume": "22", "issue": "4", "page": null, "issn": "1469-221X, 1469-3178", "isbn": null, "authors": "Roya Yousefi, Eugenio F Fornasiero, Lukas Cyganek, Julio Montoya, Stefan Jakobs, Silvio O Rizzoli, Peter Rehling, David Pacheu-Grau", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 68, "referenceCount": 52, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "European Research Council, European Research Council, Sonderforschungsbereiche, Sonderforschungsbereiche, Deutsche Forschungsgemeinschaft, Deutsche Forschungsgemeinschaft, Germany’s Excellence Strategy, German Federal Ministry of Education and Research (BMBF)/DZHK, Instituto de Salud Carlos III, Max Planck Institute for Biophysical Chemistry", "funderIds": "10.13039/501100000781, 10.13039/501100000781, 10.13039/501100001659, 10.13039/501100001659, 10.13039/501100004587", "url": "https://doi.org/10.15252/embr.202051635", "pdfUrl": "https://link.springer.com/content/pdf/10.15252/embr.202051635.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1016/j.sctalk.2022.100057", "doi": "10.1016/j.sctalk.2022.100057", "title": "Morphological transitions of flexible fibers in viscous flows", "publicationYear": 2022, "publicationDate": "2022-08", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Science Talks", "volume": "3", "issue": null, "page": "100057", "issn": "2772-5693", "isbn": null, "authors": "Anke Lindner", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 12, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Institut Pierre-Gilles de Gennes, European Research Council, Tulane University", "funderIds": "10.13039/501100018951, 10.13039/501100000781, 10.13039/100007875", "url": "https://doi.org/10.1016/j.sctalk.2022.100057", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1111/febs.70396", "doi": "10.1111/febs.70396", "title": "Bridging the gap: When transcription meets translation", "publicationYear": 2026, "publicationDate": "2026-05", "type": "journal-article", "publisher": "Wiley", "containerTitle": "The FEBS Journal", "volume": "293", "issue": "10", "page": "2811-2820", "issn": "1742-464X, 1742-4658", "isbn": null, "authors": "Huma Rahil, Albert Weixlbaumer", "authorCount": 2, "firstAuthorAffiliation": "Department of Integrated Structural Biology Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)  Illkirch France", "isReferencedByCount": 0, "referenceCount": 72, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": "European Research Council, Fondation pour la Recherche Médicale, Agence Nationale de la Recherche, Agence Nationale de la Recherche, Agence Nationale de la Recherche, Agence Nationale de la Recherche", "funderIds": "10.13039/501100000781, 10.13039/501100002915, 10.13039/501100001665, 10.13039/501100001665, 10.13039/501100001665, 10.13039/501100001665", "url": "https://doi.org/10.1111/febs.70396", "pdfUrl": "https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/febs.70396", "abstract": "Recruitment of the small ribosomal subunit (30S) to messenger RNA (mRNA) marks a key step in bacterial translation initiation. Recruitment begins with a 30S standby site binding single‐stranded mRNA regions at or near the translation initiation region (TIR). Subsequently, the mRNA is accommodated into the 30S mRNA binding channel to initiate translation. An essential part of accommodation is the recognition and proper positioning of the start codon to establish the correct reading frame. This is often facilitated by the Shine–Dalgarno (SD) sequence. Recent structural and biochemical studies provided snapshots of the first steps of 30S recruitment to a nascent mRNA preceding accommodation, which likely reflect similar events for fully transcribed mRNAs. These studies suggest that a transcribing RNA polymerase (RNAP) promotes 30S recruitment to the nascent mRNA via two distinct pathways. In one, RNAP cooperates with ribosomal protein bS1, which captures the mRNA and channels it toward the anti‐Shine–Dalgarno (aSD) sequence for base pairing. In the other, direct coupling between RNAP and the 30S, mediated by transcription factor NusG, facilitates an alternative mRNA delivery pathway. We explore the current understanding of mRNA delivery, highlighting different modes of 30S recruitment to the nascent mRNA, the role of bS1, and how this leads to the establishment of transcription–translation coupling.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.3390/land10101077", "doi": "10.3390/land10101077", "title": "Reconstruction of Residential Land Cover and Spatial Analysis of Population in Bursa Region (Turkey) in the Mid-Nineteenth Century", "publicationYear": 2021, "publicationDate": "2021-10-13", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Land", "volume": "10", "issue": "10", "page": "1077", "issn": "2073-445X", "isbn": null, "authors": "Eda Ustaoglu, Mustafa Erdem Kabadayı", "authorCount": 2, "firstAuthorAffiliation": "College of Social Sciences and Humanities, Koc University, Istanbul 34450, Turkey", "isReferencedByCount": 3, "referenceCount": 95, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.3390/land10101077", "pdfUrl": null, "abstract": "The historic reconstruction of residential land cover is of significance to uncover the human-environment relationship and its changing dynamics. Taking into account the historical census data and cadastral maps of seven villages, this study generated residential land cover maps for the Bursa Region in the 1850s using a model based on natural constraints, land zoning, socio-economic factors and residential suitability. Two different historical reconstructions were generated; one based on a high density residential model and another based on a low density model. The simulated landcover information was used as an ancillary data to redistribute aggregated census counts to fine scale raster cells. Two different statistical models were developed; one based on probability maps and the other applying regression models including Ordinary Least Squares (OLS) and Geographically Weighted Regression (GWR) models. The regression models were validated with historical census data of the 1840s. From regression models, socio-economic and physical characteristics, accessibility and natural amenities showed significant impacts on the distribution of population. Model validation analysis revealed that GWR is more accurate than OLS models. The generated residential land cover and gridded population datasets can provide a basis for the historical study of population and land use.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1002/adhm.202002163", "doi": "10.1002/adhm.202002163", "title": "Nanotechnology‐Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis", "publicationYear": 2021, "publicationDate": "2021-05", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Healthcare Materials", "volume": "10", "issue": "10", "page": null, "issn": "2192-2640, 2192-2659", "isbn": null, "authors": "Özlem Şen, Melis Emanet, Gianni Ciofani", "authorCount": 3, "firstAuthorAffiliation": "Istituto Italiano di Tecnologia Smart Bio‐Interfaces  Viale Rinaldo Piaggio 34 Pontedera Pisa 56025 Italy", "isReferencedByCount": 25, "referenceCount": 272, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/4.0/", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.1002/adhm.202002163", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/adhm.202002163", "abstract": "AbstractCancer metastasis is the major cause of cancer‐related morbidity and mortality. It represents one of the greatest challenges in cancer therapy, both because of the ability of metastatic cells to spread into different organs, and because of the consequent heterogeneity that characterizes primary and metastatic tumors. Nanomaterials can potentially be used as targeting or detection agents owing to unique chemical and physical features that allow tailored and tunable theranostic functions. This review highlights nanomaterial‐based approaches in the detection and treatment of cancer metastasis, with a special focus on the evaluation of nanostructure effects on cell migration, invasion, and angiogenesis in the tumor microenvironment.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1007/s00396-025-05475-8", "doi": "10.1007/s00396-025-05475-8", "title": "Role of fluorocarbons in PUR foams: a cryo-SEM study", "publicationYear": 2025, "publicationDate": "2025-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Colloid and Polymer Science", "volume": "303", "issue": "12", "page": "2463-2479", "issn": "0303-402X, 1435-1536", "isbn": null, "authors": "Martin Hamann, Alain Carvalho, Marc Schmutz, Luca Fiorucci, Daniel Telkemeyer, Markus Schütte, Wiebke Drenckhan-Andreatta", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": "European Research Council, European Research Council, European Research Council, European Research Council, European Research Council, Agence Nationale de la Recherche, Agence Nationale de la Recherche, Agence Nationale de la Recherche, Agence Nationale de la Recherche, Agence Nationale de la Recherche, BASF", "funderIds": "10.13039/501100000781, 10.13039/501100000781, 10.13039/501100000781, 10.13039/501100000781, 10.13039/501100000781, 10.13039/501100001665, 10.13039/501100001665, 10.13039/501100001665, 10.13039/501100001665, 10.13039/501100001665, 10.13039/100004349", "url": "https://doi.org/10.1007/s00396-025-05475-8", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s00396-025-05475-8.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1371/journal.pbio.3002787", "doi": "10.1371/journal.pbio.3002787", "title": "Incomplete lytic cycle of a widespread Bacteroides bacteriophage leads to the formation of defective viral particles", "publicationYear": 2025, "publicationDate": "2025-03-31", "type": "journal-article", "publisher": "Public Library of Science (PLoS)", "containerTitle": "PLOS Biology", "volume": "23", "issue": "3", "page": "e3002787", "issn": "1545-7885", "isbn": null, "authors": "Sol Vendrell-Fernández, Beatriz Beamud, Yasmina Abou Haydar, Jorge Am de Sousa, Julien Burlaud-Gaillard, Etienne Kornobis, Bertrand Raynal, Joelle Vinh, David Bikard, Jean-Marc Ghigo", "authorCount": 10, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 89, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Agence Nationale de la Recherche, Agence Nationale de la Recherche, Agence Nationale de la Recherche, Agence Nationale de la Recherche, Agence Nationale de la Recherche, European Research Council, Agence Nationale de la Recherche", "funderIds": "10.13039/501100001665, 10.13039/501100001665, 10.13039/501100001665, 10.13039/501100001665, 10.13039/501100001665, 10.13039/501100000781, 10.13039/501100001665", "url": "https://doi.org/10.1371/journal.pbio.3002787", "pdfUrl": null, "abstract": "Advances in metagenomics have led to the identification of new intestinal temperate bacteriophages. However, their experimental characterization remains challenging due to a limited understanding of their lysogenic-lytic cycle and the common lack of plaque formation in vitro. In this study, we investigated the hankyphage, a widespread transposable phage of prominent Bacteroides symbionts. Hankyphages spontaneously produced virions in laboratory conditions even in the absence of inducer, but virions did not show any evidence of infectivity. To increase virion production and raise the chances of observing infection events, we identified a master repressor of the hankyphage lytic cycle, RepC HP , whose silencing amplified hankyphage gene expression, and enhanced replicative transposition and virion production. However, attempts to infect or lysogenize new host cells with different capsular types remained unsuccessful. Transmission electron microscopy and capsid DNA sequencing revealed an abnormal virion morphology and incomplete DNA packaging of the hankyphage, suggesting that it cannot complete its assembly in laboratory conditions for reasons that are yet to be identified. Still, metavirome and phylogenetic analyses were suggestive of hankyphage horizontal transmission. We could also detect the activity of diversity-generating retroelements (DGRs) that mutagenize the hankyphage tail fiber, and likely contribute to its broad host range. This study sheds light on the life cycle of this abundant intestinal bacteriophage and highlights important gaps in our understanding of the factors required for the completion of its life cycle. Elucidating this puzzle will be critical to gain a better understanding of the hankyphage biology and ecological role.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.3390/cells13201696", "doi": "10.3390/cells13201696", "title": "Generation of a Biotin-Tagged Dual-Display Phage", "publicationYear": 2024, "publicationDate": "2024-10-14", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Cells", "volume": "13", "issue": "20", "page": "1696", "issn": "2073-4409", "isbn": null, "authors": "Laura Maria De Plano, Salvatore Oddo, David Bikard, Antonella Caccamo, Sabrina Conoci", "authorCount": 5, "firstAuthorAffiliation": "Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d’Alcontres 31, 98166 Messina, Italy", "isReferencedByCount": 1, "referenceCount": 36, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Union’s Horizon Europe EICPathfinder Open Programme “ECLIPSE project”, European Research Council, Agence Nationale de la Recherche", "funderIds": "10.13039/501100000780, 10.13039/501100000781, 10.13039/501100001665", "url": "https://doi.org/10.3390/cells13201696", "pdfUrl": null, "abstract": "Phage display is widely used in biomedical research. One of the great advantages of phage display is the specificity of the connection of a foreign peptide exposed outside the capsid to the intended target. Secondary detection systems, which are often laborious and costly, are required to identify and quantify the peptide/target interaction. In this study, we generated a novel dual-display phage to facilitate the detection and quantification of the peptide/target interaction. First, we generated a biotin-tagged phage by adding a small biotin-accepting peptide (sBT) to gene-3 of the M13K07 helper phage. Subsequently, we enhanced the M13K07 biotin-tagged phage by incorporating a selective peptide on gene-8, which is then exposed to the phage capsid. The exposed peptide acts as a probe to bind to a selective molecular target, whose interaction can be readily visualized thanks to the biotinylated phage. Our versatile dual-display phage exhibits high flexibility; by swapping the displayed peptide/probe, one can change the phage target while retaining the sBT gene in-frame with the pIII. We expect the generated biotin-tagged dual phages to be used as a multifunctional probe to couple with several streptavidin-biotin-based systems.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.3390/land10101005", "doi": "10.3390/land10101005", "title": "Codifying and Commodifying Nature: Narratives on Forest Property Rights and the Implementation of Tenure Regularization Policies in Northwestern Argentina", "publicationYear": 2021, "publicationDate": "2021-09-24", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Land", "volume": "10", "issue": "10", "page": "1005", "issn": "2073-445X", "isbn": null, "authors": "Carla Inguaggiato, Michele Graziano Ceddia, Maurice Tschopp, Dimitris Christopoulos", "authorCount": 4, "firstAuthorAffiliation": "Centre for Development and Environment (CDE), University of Bern, 3012 Bern, Switzerland", "isReferencedByCount": 3, "referenceCount": 61, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.3390/land10101005", "pdfUrl": null, "abstract": "Environmental resource management requires negotiation among state and non-state actors with conflicting goals and different levels of influence. In northwestern Argentina, forest policy implementation is described as weak, due to governance structure and ambiguities in the law. We studied how policy actors’ attitudes and their positions in the forest governance network relate to the implementation of land tenure regularization in a context where land tenure regularization is at the core of struggles over environmental policies. We focused on the Chaco Salteño part of the Gran Chaco ecosystem, one of the world’s major deforestation frontiers. We argue that the presence of weak advocacy coalitions requires an analysis of agency to understand this policy process. Our policy network analysis revealed a lack of clear contrasting factions, due to a core–periphery structure. The core of the network brings together all core beliefs but not all of the most influential actors. Assessing network centrality and reputational influence enabled us to identify actors with exceptional agency. We contribute to the debates on advocacy coalitions and on land tenure by distinguishing between attitudes toward tenure regularization policies and their actual implementation in a context where actors have diverging interests and objectives.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.7554/elife.70408", "doi": "10.7554/elife.70408", "title": "Calcium dependence of neurotransmitter release at a high fidelity synapse", "publicationYear": 2021, "publicationDate": "2021-10-06", "type": "journal-article", "publisher": "eLife Sciences Publications, Ltd", "containerTitle": "eLife", "volume": "10", "issue": null, "page": null, "issn": "2050-084X", "isbn": null, "authors": "Abdelmoneim Eshra, Hartmut Schmidt, Jens Eilers, Stefan Hallermann", "authorCount": 4, "firstAuthorAffiliation": "Carl-Ludwig-Institute for Physiology, Medical Faculty, University of Leipzig, Leipzig, Germany", "isReferencedByCount": 55, "referenceCount": 121, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Deutsche Forschungsgemeinschaft, Deutsche Forschungsgemeinschaft, European Research Council", "funderIds": "10.13039/501100001659, 10.13039/501100001659, 10.13039/501100000781", "url": "https://doi.org/10.7554/elife.70408", "pdfUrl": "https://cdn.elifesciences.org/articles/70408/elife-70408-v1.pdf", "abstract": "The Ca 2+ -dependence of the priming, fusion, and replenishment of synaptic vesicles are fundamental parameters controlling neurotransmitter release and synaptic plasticity. Despite intense efforts, these important steps in the synaptic vesicles’ cycle remain poorly understood due to the technical challenge in disentangling vesicle priming, fusion, and replenishment. Here, we investigated the Ca 2+ -sensitivity of these steps at mossy fiber synapses in the rodent cerebellum, which are characterized by fast vesicle replenishment mediating high-frequency signaling. We found that the basal free Ca 2+ concentration (&lt;200 nM) critically controls action potential-evoked release, indicating a high-affinity Ca 2+ sensor for vesicle priming. Ca 2+ uncaging experiments revealed a surprisingly shallow and non-saturating relationship between release rate and intracellular Ca 2+ concentration up to 50 μM. The rate of vesicle replenishment during sustained elevated intracellular Ca 2+ concentration exhibited little Ca 2+ -dependence. Finally, quantitative mechanistic release schemes with five Ca 2+ binding steps incorporating rapid vesicle replenishment via parallel or sequential vesicle pools could explain our data. We thus show that co-existing high- and low-affinity Ca 2+ sensors mediate priming, fusion, and replenishment of synaptic vesicles at a high-fidelity synapse.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1002/adhm.202001993", "doi": "10.1002/adhm.202001993", "title": "An Immunomodulatory Miniaturized 3D Screening Platform Using Liquefied Capsules", "publicationYear": 2021, "publicationDate": "2021-05", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Healthcare Materials", "volume": "10", "issue": "10", "page": null, "issn": "2192-2640, 2192-2659", "isbn": null, "authors": "Sara Nadine, Clara R. Correia, João F. Mano", "authorCount": 3, "firstAuthorAffiliation": "CICECO – Aveiro Institute of Materials Department of Chemistry University of Aveiro Campus Universitário de Santiago  Aveiro 3810‐193 Portugal", "isReferencedByCount": 18, "referenceCount": 60, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.1002/adhm.202001993", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/adhm.202001993", "abstract": "AbstractA critical determinant of successful clinical outcomes is the host's response to the biomaterial. Therefore, the prediction of the immunomodulatory bioperformance of biomedical devices following implantation is of utmost importance. Herein, liquefied capsules are proposed as immunomodulatory miniaturized 3D platforms for the high‐content combinatorial screening of different polymers that could be used generically in scaffolds. Additionally, the confined and liquefied core of capsules affords a cell‐mediated 3D assembly with bioinstructive microplatforms, allowing to study the potential synergistic effect that cells in tissue engineering therapies have on the immunological environment before implantation. As a proof‐of‐concept, three different polyelectrolytes, ranging in charge density and source, are used. Poly(L‐lysine)‐, alginate‐, and chitosan‐ending capsules with or without encapsulated mesenchymal stem/stromal cells (MSCs) are placed on top of a 2D culture of macrophages. Results show that chitosan‐ending capsules, as well as the presence of MSCs, favor the balance of macrophage polarization toward a more regenerative profile, through the up‐regulation of anti‐inflammatory markers, and the release of pro‐regenerative cytokines. Overall, the developed system enables the study of the immunomodulatory bioperformance of several polymers in a cost‐effective and scalable fashion, while the paracrine signaling between encapsulated cells and the immunological environment can be simultaneously evaluated.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.3390/biology10101045", "doi": "10.3390/biology10101045", "title": "Antiviral Function of NKEF against VHSV in Rainbow Trout", "publicationYear": 2021, "publicationDate": "2021-10-15", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Biology", "volume": "10", "issue": "10", "page": "1045", "issn": "2079-7737", "isbn": null, "authors": "Veronica Chico, Maria Elizabhet Salvador-Mira, Ivan Nombela, Sara Puente-Marin, Luis Perez, Luis Mercado, Maria del Mar Ortega-Villaizan", "authorCount": 7, "firstAuthorAffiliation": "Instituto de Biología Molecular y Celular (IBMC), Universidad Miguel Hernández (IBMC-UMH), 03202 Elche, Spain", "isReferencedByCount": 8, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.3390/biology10101045", "pdfUrl": null, "abstract": "Natural killer enhancing factor (NKEF) belongs to the peroxiredoxin family of proteins, a group of antioxidants that has been extensively studied in mammals. Recently, we identified NKEF in the immunoprecipitated proteome of rainbow trout red blood cells (RBCs) exposed to viral hemorrhagic septicemia virus (VHSV). In the present study, we evaluated the role of NKEF in the antiviral response of rainbow trout against VHSV by examining the expression profile of NKEF in VHSV-exposed RBCs and rainbow trout gonad-2 (RTG-2) cell line. We found an in vitro correlation between decreased VHSV replication and increased NKEF expression after RBCs were exposed to VHSV, however this was not found in RTG-2 cells where the infection highly increased and nkef transcripts remained almost unchanged. In addition, siRNA silencing of the nkef gene in rainbow trout RBCs and RTG-2 cells resulted in increased VHSV replication. We also found a correlation between nkef gene silencing and a decrease in the expression of genes related to type 1 interferon (IFN1) pathway. These findings indicated that NKEF is involved in the antiviral mechanisms of rainbow trout RBCs against VHSV and thus support its antiviral role and implication in the modulation of their immune response. Finally, overexpression of NKEF in an EPC cell line significantly reduced VHSV infectivity and was coupled to an increment in IFN1-related genes. In conclusion, NKEF may be a potential target for new therapeutic strategies against viral infections.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1111/1365-2656.70247", "doi": "10.1111/1365-2656.70247", "title": "Spider mite genotypes with higher growth rate suffer more from competition but exert stronger reproductive interference", "publicationYear": 2026, "publicationDate": "2026-06", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Journal of Animal Ecology", "volume": "95", "issue": "6", "page": "1002-1014", "issn": "0021-8790, 1365-2656", "isbn": null, "authors": "Miguel A. Cruz, Flore Zélé, Raquel Gaspar, Ricardo Santos, Leonor R. Rodrigues, Vitor C. Sousa, Sara Magalhães", "authorCount": 7, "firstAuthorAffiliation": "Centre for Ecology, Evolution and Environmental Changes (CE3C) &amp; CHANGE ‐ Global Change and Sustainability Institute Faculdade de Ciências da Universidade de Lisboa  Lisbon Portugal", "isReferencedByCount": 1, "referenceCount": 88, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council, Fundação para a Ciência e a Tecnologia, Fundação para a Ciência e a Tecnologia, Fundação para a Ciência e a Tecnologia, Fundação para a Ciência e a Tecnologia, Fundação para a Ciência e a Tecnologia", "funderIds": "10.13039/501100000781, 10.13039/501100001871, 10.13039/501100001871, 10.13039/501100001871, 10.13039/501100001871, 10.13039/501100001871", "url": "https://doi.org/10.1111/1365-2656.70247", "pdfUrl": "https://besjournals.onlinelibrary.wiley.com/doi/pdf/10.1111/1365-2656.70247", "abstract": "Abstract Within‐species individual variation has been gaining increased attention in ecological studies of species interactions. Yet, these studies rarely consider genetic variation and potential genetic correlations among traits. Moreover, traits beyond those associated with trophic interactions are mostly overlooked. Filling these gaps is important to fully understand the relevance of trait variation in both the ecology and evolution of species interactions. We addressed this using inbred lines of Tetranychus cinnabarinus , a spider mite species that often engages in antagonistic interactions with its congeneric T. urticae . Specifically, we measured (a) the intrinsic growth rate and the sex ratio in the absence of food competition and reproductive interference; (b) food competition against a density gradient of conspecific or heterospecific competitors in the absence of reproductive interference; (c) reproductive interference in the absence of food competition; and (d) the body size of adult females and males. We found significant genetic variance (i.e. broad‐sense heritability) among lines for all variables except for the effect of T. cinnabarinus on its heterospecific competitor via food competition. Moreover, we showed that lines with higher intrinsic growth were more sensitive to intra‐ and interspecific competition for food but exerted stronger reproductive interference on heterospecifics. In addition, the higher the proportion of sons produced by a line, the more resilient it was to reproductive interference but also the lower its growth rate. No genetic correlations were found between any variable and body size. Our results indicate that considering genetic correlations among traits involved in both trophic and sexual interactions is key to understanding the role of individual variation in species interactions and their evolution.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1073/pnas.2528457123", "doi": "10.1073/pnas.2528457123", "title": "Discovery of dynamical heterogeneity in a supercooled magnetic monopole fluid", "publicationYear": 2026, "publicationDate": "2026-06-09", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "123", "issue": "23", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Jahnatta Dasini, Chaia Carroll, Jack Murphy, Catherine Dawson, Hiroto Takahashi, Sudarshan Sharma, Fabian Jerzembeck, Stephen J. Blundell, Graeme M. Luke, J. C. Séamus Davis, Jonathan Ward", "authorCount": 11, "firstAuthorAffiliation": "Department of Physics, University College Cork", "isReferencedByCount": 0, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Research Ireland, Research Ireland, International Max Planck Research School for Chemistry and Physics of Quantum Materials, UK Research and Innovation, Gordon and Betty Moore Foundation, EC | European Research Council, Royal Society, Research Ireland, Royal Society", "funderIds": "10.13039/501100025294, 10.13039/501100025294, 10.13039/501100017516, 10.13039/100014013, 10.13039/100000936, 10.13039/501100000781, 10.13039/501100000288, 10.13039/501100025294, 10.13039/501100000288", "url": "https://doi.org/10.1073/pnas.2528457123", "pdfUrl": null, "abstract": "Dynamical heterogeneity, in which transitory local fluctuations occur in the conformation and dynamics of constituent particles, is widely hypothesized to be essential to the evolution of supercooled liquids into the structural glass state. Yet its microscopic spatiotemporal phenomenology is challenging to detect directly in molecular glass forming liquids. Because recent theoretical advances predict that corresponding dynamical heterogeneity could occur in supercooled magnetic monopole fluids (Proc. Nat. Acad. Sci. 112, 8549 (2015)), we searched for such phenomena in Dy 2 Ti 2 O 7 . By measuring its microsecond-resolved spontaneous magnetization fluctuations M ( t , T ) we detected a sharp bifurcation in monopole noise characteristics below T ≈ 1,500 mK , with the appearance of powerful spontaneous monopole current bursts. This intense dynamics emerges upon entering the supercooled monopole fluid regime, reaches maximum strength near T ≈ 750 mK and then collapses along with coincident loss of ergodicity approaching T g ≈ 250 mK . Moreover, when the four-point dynamical susceptibility χ 4 ( τ , T ) is determined directly from temperature dependence of correlations in M ( t , T ) , it evolves as predicted when dynamical heterogeneity is present, revealing its simultaneously and rapidly escalating length and time scales, ξ ( T ) and τ 4 ( T ) . This overall phenomenology greatly expands our empirical knowledge of supercooled monopole fluids and, more generally, demonstrates techniques for detection of the time sequence, magnitude, statistics, and correlations of dynamical heterogeneity, access to which may greatly accelerate fundamental vitrification studies.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.3390/jcm10030482", "doi": "10.3390/jcm10030482", "title": "Genome Editing for β-Hemoglobinopathies: Advances and Challenges", "publicationYear": 2021, "publicationDate": "2021-01-28", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Journal of Clinical Medicine", "volume": "10", "issue": "3", "page": "482", "issn": "2077-0383", "isbn": null, "authors": "Giacomo Frati, Annarita Miccio", "authorCount": 2, "firstAuthorAffiliation": "Laboratory of Chromatin and Gene Regulation during Development, Imagine Institute, Université de Paris, INSERM UMR 1163, F-75015 Paris, France", "isReferencedByCount": 30, "referenceCount": 119, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Agence Nationale de la Recherche, European Research Council, French Muscular Dystrophy Association", "funderIds": "10.13039/501100001665, 10.13039/501100000781, 10.13039/100013465", "url": "https://doi.org/10.3390/jcm10030482", "pdfUrl": null, "abstract": "β-hemoglobinopathies are the most common genetic disorders worldwide and are caused by mutations affecting the production or the structure of adult hemoglobin. Patients affected by these diseases suffer from anemia, impaired oxygen delivery to tissues, and multi-organ damage. In the absence of a compatible donor for allogeneic bone marrow transplantation, the lifelong therapeutic options are symptomatic care, red blood cell transfusions and pharmacological treatments. The last decades of research established lentiviral-mediated gene therapy as an efficacious therapeutic strategy. However, this approach is highly expensive and associated with a variable outcome depending on the effectiveness of the viral vector and the quality of the cell product. In the last years, genome editing emerged as a valuable tool for the development of curative strategies for β-hemoglobinopathies. Moreover, due to the wide range of its applications, genome editing has been extensively used to study regulatory mechanisms underlying globin gene regulation allowing the identification of novel genetic and pharmacological targets. In this work, we review the current advances and challenges of genome editing approaches to β-hemoglobinopathies. Special focus has been directed towards strategies aimed at correcting the defective β-globin gene or at inducing fetal hemoglobin (HbF), which are in an advanced state of clinical development.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1136/bmjgh-2025-021061", "doi": "10.1136/bmjgh-2025-021061", "title": "Towards a complex systems model of evidence for public health", "publicationYear": 2025, "publicationDate": "2025-10", "type": "journal-article", "publisher": "BMJ", "containerTitle": "BMJ Global Health", "volume": "10", "issue": "10", "page": "e021061", "issn": "2059-7908", "isbn": null, "authors": "Karien Stronks, Morten Hulvej Rod, Harry Rutter, Naja Hulvej Rod", "authorCount": 4, "firstAuthorAffiliation": "Department of Public and Occupational Health, Amsterdam UMC/University of Amsterdam, Amsterdam, The Netherlands", "isReferencedByCount": 10, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.1136/bmjgh-2025-021061", "pdfUrl": null, "abstract": "There has been growing interest in the adoption of complex systems approaches to tackle major public health challenges such as obesity. This perspective redirects focus from individually oriented and narrowly focused interventions towards strategies that reshape structural drivers of health and disease across multiple levels, offering novel avenues for enhancing population health and tackling health inequalities. Despite growing consensus on the use of a complex systems model of evidence to support these kinds of approaches, there remains limited agreement on the types of evidence required both to understand and to tackle complex public health problems. In this paper, we propose a complex systems model of evidence that combines three types of evidence—causal, intervention, implementation—across three dimensions of complex systems—mechanisms, dynamics and patterns. This model thus identifies nine categories of evidence: causal evidence , which explains the mechanisms behind public health problems, the dynamics driving changes therein and emerging health patterns; intervention evidence, which focuses on the set of actions that can modify these mechanisms and dynamics, including their intended and unintended consequences on health outcomes and implementation evidence, which addresses what is needed to implement systems change effectively, how systems adapt to these changes and how systems changes contribute to changes in health patterns. This complex systems model of evidence may serve as a guide to researchers and decision-makers when designing research programmes and evidence-based policies in response to complex public health problems.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.3389/fevo.2022.865398", "doi": "10.3389/fevo.2022.865398", "title": "Synchrony and Stability in Trophic Metacommunities: When Top Predators Navigate in a Heterogeneous World", "publicationYear": 2022, "publicationDate": "2022-07-15", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Ecology and Evolution", "volume": "10", "issue": null, "page": null, "issn": "2296-701X", "isbn": null, "authors": "Pierre Quévreux, Michel Loreau", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 15, "referenceCount": 72, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council, Laboratoire d'Excellence TULIP", "funderIds": "10.13039/501100000781, 10.13039/100018956", "url": "https://doi.org/10.3389/fevo.2022.865398", "pdfUrl": null, "abstract": "Ecosystem stability strongly depends on spatial aspects since localized perturbations spread across an entire region through species dispersal. Assessing the synchrony of the response of connected populations is fundamental to understand stability at different scales because if populations fluctuate asynchronously, the risk of their simultaneous extinction is low, thus reducing the species' regional extinction risk. Here, we consider a metacommunity model consisting of two food chains connected by dispersal and we review the various mechanisms governing the transmission of small perturbations affecting populations in the vicinity of equilibrium. First, we describe how perturbations propagate vertically (i.e., within food chains through trophic interactions) and horizontally (i.e., between food chains through dispersal) in metacommunities. Then, we discuss the mechanisms susceptible to alter synchrony patterns such as density-depend dispersal or spatial heterogeneity. Density-dependent dispersal, which is the influence of prey or predator abundance on dispersal, has a major impact because the species with the highest coefficient of variation of biomass governs the dispersal rate of the dispersing species and determines the synchrony of its populations, thus bypassing the classic vertical transmission of perturbations. Spatial heterogeneity, which is a disparity between patches of the attack rate of predators on prey in our model, alters the vertical transmission of perturbations in each patch, thus making synchrony dependent on which patch is perturbed. Finally, by combining our understanding of the impact of each of these mechanisms on synchrony, we are able to full explain the response of realistic metacommunities such as the model developed by Rooney et al. (2006). By disentangling the main mechanisms governing synchrony, our metacommunity model provides a broad insight into the consequences of spacial aspects on food web stability.", "subject": null, "language": null, "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.3390/biom13040670", "doi": "10.3390/biom13040670", "title": "The Emerging Role of IL-9 in the Anticancer Effects of Anti-PD-1 Therapy", "publicationYear": 2023, "publicationDate": "2023-04-12", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Biomolecules", "volume": "13", "issue": "4", "page": "670", "issn": "2218-273X", "isbn": null, "authors": "Daria Vinokurova, Lionel Apetoh", "authorCount": 2, "firstAuthorAffiliation": "UMR 1231, Lipides Nutrition Cancer, INSERM, 21000 Dijon, France", "isReferencedByCount": 13, "referenceCount": 77, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Fondation de France, Fondation de France, Fondation de France, Fondation de France, Fondation pour la Recherche Médicale, Fondation pour la Recherche Médicale, Fondation pour la Recherche Médicale, Fondation pour la Recherche Médicale, Conseil Régional de Bourgogne, Conseil Régional de Bourgogne, Conseil Régional de Bourgogne, Conseil Régional de Bourgogne, FEDER, FEDER, FEDER, FEDER, LabEx LipSTIC, LabEx LipSTIC, LabEx LipSTIC, LabEx LipSTIC, LabEx MAbImprove, LabEx MAbImprove, LabEx MAbImprove, LabEx MAbImprove, European Research Council, European Research Council, European Research Council, European Research Council, Brown Center for Immunotherapy at Indiana University Melvin, Brown Center for Immunotherapy at Indiana University Melvin, Brown Center for Immunotherapy at Indiana University Melvin, Brown Center for Immunotherapy at Indiana University Melvin, Bren Simon Comprehensive Cancer Center, Bren Simon Comprehensive Cancer Center, Bren Simon Comprehensive Cancer Center, Bren Simon Comprehensive Cancer Center", "funderIds": "10.13039/501100002915, 10.13039/501100002915, 10.13039/501100002915, 10.13039/501100002915, 10.13039/501100000781, 10.13039/501100000781, 10.13039/501100000781, 10.13039/501100000781", "url": "https://doi.org/10.3390/biom13040670", "pdfUrl": null, "abstract": "PD-1 blockade rescues failing anticancer immune responses, resulting in durable remissions in some cancer patients. Cytokines such as IFNγ and IL-2 contribute to the anti-tumor effect of PD-1 blockade. IL-9 was identified over the last decade as a cytokine demonstrating a potent ability to harness the anticancer functions of innate and adaptive immune cells in mice. Recent translational investigations suggest that the anticancer activity of IL-9 also extends to some human cancers. Increased T cell-derived IL-9 was proposed to predict the response to anti-PD-1 therapy. Preclinical investigations accordingly revealed that IL-9 could synergize with anti-PD-1 therapy in eliciting anticancer responses. Here, we review the findings suggesting an important contribution of IL-9 in the efficacy of anti-PD-1 therapy and discuss their clinical relevance. We will also discuss the role of host factors like the microbiota and TGFβ in the tumor microenvironment (TME) in the regulation of IL-9 secretion and anti-PD-1 treatment efficacy.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1002/admt.202500190", "doi": "10.1002/admt.202500190", "title": "Rapid Manufacturing of High‐Permittivity Dielectric Elastomer Actuator Fibers", "publicationYear": 2025, "publicationDate": "2025-05", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Materials Technologies", "volume": "10", "issue": "10", "page": null, "issn": "2365-709X, 2365-709X", "isbn": null, "authors": "Patrick M. Danner, Tazio Pleij, Florent Liechti, Jana Wolf, Alexandra V. Bayles, Jan Vermant, Dorina M. Opris", "authorCount": 7, "firstAuthorAffiliation": "Swiss Federal Laboratories for Materials Science and Technology – Empa Laboratory for Functional Polymers  Ueberlandstr. 129 Dübendorf CH‐8600 Switzerland", "isReferencedByCount": 8, "referenceCount": 37, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.1002/admt.202500190", "pdfUrl": null, "abstract": "Abstract The fast and scalable production of dielectric elastomer actuators (DEAs) remains the major bottleneck preventing the widespread use of DEAs. In this work, an ultra‐fast production method is presented for dielectric elastomer fibers which can reach industrial‐like extrusion speeds of up to 60 mm s −1 of fiber, leading to a production speed of up to 16.7 m of fiber per second or 216 m per hour. Electrode and high permittivity (' = 11.2) dielectric inks are used with a long pot life, but ultra‐fast cross‐linking at elevated temperatures. The process eliminates the need for tedious and time‐consuming post‐processing, as simple co‐extrusion and laser ablation enable the production of fully functional, high‐permittivity DEA fibers within seconds. This work represents a significant advancement in DEA manufacturing, transitioning from conventional layer‐by‐layer batch production to continuous co‐extrusion‐based manufacturing. To the best of the knowledge, this is currently the fastest method for fabricating fully functional DEAs in a single processing step.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1021/acssensors.4c03633", "doi": "10.1021/acssensors.4c03633", "title": "Integration Strategies and Formats in Field-Effect Transistor Chemo- and Biosensors: A Critical Review", "publicationYear": 2025, "publicationDate": "2025-04-25", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "ACS Sensors", "volume": "10", "issue": "4", "page": "2431-2452", "issn": "2379-3694, 2379-3694", "isbn": null, "authors": "Željko Janićijević, Larysa Baraban", "authorCount": 2, "firstAuthorAffiliation": "Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf e. V. (HZDR)", "isReferencedByCount": 24, "referenceCount": 107, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council, Deutsche Forschungsgemeinschaft, Deutsche Forschungsgemeinschaft", "funderIds": "10.13039/501100000781, 10.13039/501100001659, 10.13039/501100001659", "url": "https://doi.org/10.1021/acssensors.4c03633", "pdfUrl": "https://pubs.acs.org/doi/pdf/10.1021/acssensors.4c03633", "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1016/j.cels.2022.11.004", "doi": "10.1016/j.cels.2022.11.004", "title": "Distinct gene programs underpinning disease tolerance and resistance in influenza virus infection", "publicationYear": 2022, "publicationDate": "2022-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Systems", "volume": "13", "issue": "12", "page": "1002-1015.e9", "issn": "2405-4712", "isbn": null, "authors": "Ofir Cohn, Gal Yankovitz, Naama Peshes-Yaloz, Yael Steuerman, Amit Frishberg, Rachel Brandes, Michal Mandelboim, Jennifer R. Hamilton, Tzachi Hagai, Ido Amit, Mihai G. Netea, Nir Hacohen, Fuad A. Iraqi, Eran Bacharach, Irit Gat-Viks", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 23, "referenceCount": 69, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Chan Zuckerberg Initiative, Chan Zuckerberg Initiative, United States-Israel Binational Science Foundation, United States-Israel Binational Science Foundation, United States-Israel Binational Science Foundation, United States-Israel Binational Science Foundation, Horizon 2020, Horizon 2020, ERC, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Tel Aviv University, European Research Council", "funderIds": "10.13039/100014989, 10.13039/100014989, 10.13039/501100001742, 10.13039/501100001742, 10.13039/501100001742, 10.13039/501100001742, 10.13039/501100007601, 10.13039/501100007601, 10.13039/100010663, 10.13039/501100003246, 10.13039/501100004375, 10.13039/501100000781", "url": "https://doi.org/10.1016/j.cels.2022.11.004", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1021/acssensors.5c01920", "doi": "10.1021/acssensors.5c01920", "title": "Plasmon-Induced Graphene/Silicon Schottky Junctions for Ultrasensitive Gas Sensing", "publicationYear": 2025, "publicationDate": "2025-10-24", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "ACS Sensors", "volume": "10", "issue": "10", "page": "7650-7660", "issn": "2379-3694, 2379-3694", "isbn": null, "authors": "Katarzyna Drozdowska, Janusz Smulko, Tesfalem Welearegay, Lars Österlund, Sergey Rumyantsev", "authorCount": 5, "firstAuthorAffiliation": "Department of Metrology and Electronic Systems, Faculty of Electronics, Telecommunications, and Informatics, Gdańsk University of Technology, G. Narutowicza 11/12, 80-233 Gdańsk, Poland", "isReferencedByCount": 3, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council, Narodowe Centrum Nauki", "funderIds": "10.13039/501100000781, 10.13039/501100004281", "url": "https://doi.org/10.1021/acssensors.5c01920", "pdfUrl": "https://pubs.acs.org/doi/pdf/10.1021/acssensors.5c01920", "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1039/d4lc00246f", "doi": "10.1039/d4lc00246f", "title": "Deformation under flow and morphological recovery of cancer cells", "publicationYear": 2024, "publicationDate": "2024", "type": "journal-article", "publisher": "Royal Society of Chemistry (RSC)", "containerTitle": "Lab on a Chip", "volume": "24", "issue": "16", "page": "3930-3944", "issn": "1473-0197, 1473-0189", "isbn": null, "authors": "Emile Gasser, Emilie Su, Kotryna Vaidžiulytė, Nassiba Abbade, Hamizah Cognart, Jean-Baptiste Manneville, Jean-Louis Viovy, Matthieu Piel, Jean-Yves Pierga, Kyohei Terao, Catherine Villard", "authorCount": 11, "firstAuthorAffiliation": "Institut Curie and Institut Pierre Gilles de Gennes, Physique des Cellules et Cancer, CNRS UMR168, Université PSL, F-75005 Paris, France", "isReferencedByCount": 10, "referenceCount": 66, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/3.0/", "funderNames": "European Research Council, Institut Pierre-Gilles de Gennes, Institut Pierre-Gilles de Gennes, Institut Pierre-Gilles de Gennes, Japan Science and Technology Agency", "funderIds": "10.13039/501100000781, 10.13039/501100018951, 10.13039/501100018951, 10.13039/501100018951, 10.13039/501100002241", "url": "https://doi.org/10.1039/d4lc00246f", "pdfUrl": "http://pubs.rsc.org/en/content/articlepdf/2024/LC/D4LC00246F", "abstract": "A novel microfluidic device dedicated to cell rheology after flow-induced deformation in constricted channel: a focus on the recovery properties of circulating tumor cells.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1080/21541264.2021.1981713", "doi": "10.1080/21541264.2021.1981713", "title": "Macromolecular assemblies supporting transcription-translation coupling", "publicationYear": 2021, "publicationDate": "2021-08-08", "type": "journal-article", "publisher": "Informa UK Limited", "containerTitle": "Transcription", "volume": "12", "issue": "4", "page": "103-125", "issn": "2154-1264, 2154-1272", "isbn": null, "authors": "Michael W. Webster, Albert Weixlbaumer", "authorCount": 2, "firstAuthorAffiliation": "Institut de Gé né tique et de Biologie Molé culaire et Cellulaire (IGBMC)", "isReferencedByCount": 28, "referenceCount": 128, "isOpenAccess": true, "licenseUrl": null, "funderNames": "Agence Nationale de la Recherche, Agence Nationale de la Recherche, European Research Council, European molecular biology organization", "funderIds": "10.13039/501100001665, 10.13039/501100001665, 10.13039/501100000781, 10.13039/100004410", "url": "https://doi.org/10.1080/21541264.2021.1981713", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.7554/elife.106040.2", "doi": "10.7554/elife.106040.2", "title": "In vivo autofluorescence lifetime imaging of spatial metabolic heterogeneities and learning-induced changes in the Drosophila mushroom body", "publicationYear": 2026, "publicationDate": "2026-01-13", "type": "posted-content", "publisher": "eLife Sciences Publications, Ltd", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Philémon Roussel, Mingyi Zhou, Chiara Stringari, Thomas Preat, Pierre-Yves Plaçais, Auguste Genovesio", "authorCount": 6, "firstAuthorAffiliation": "Computational Bioimaging and Bioinformatics, IBENS, École normale supérieure, CNRS, INSERM, Université PSL", "isReferencedByCount": 0, "referenceCount": 97, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Agence Nationale de la Recherche, Agence Nationale de la Recherche, Agence Nationale de la Recherche, Agence Nationale de la Recherche, Agence Nationale de la Recherche, EC | European Research Council", "funderIds": "10.13039/501100001665, 10.13039/501100001665, 10.13039/501100001665, 10.13039/501100001665, 10.13039/501100001665, 10.13039/501100000781", "url": "https://doi.org/10.7554/elife.106040.2", "pdfUrl": "https://cdn.elifesciences.org/preprints/106040/elife-preprint-106040-v2.pdf", "abstract": "Neuronal energy regulation is increasingly recognized as a critical factor underlying brain functions and their pathological alterations, yet the metabolic dynamics that accompany cognitive processes remain poorly understood. As a label-free and minimally invasive technique, fluorescence lifetime imaging (FLIM) of coenzymes NADH and NADPH (collectively referred to as NAD(P)H) offers the possibility to resolve cellular metabolic profiles with high spatial precision. However, NAD(P)H FLIM’s capacity to detect subtle variations in neuronal metabolism has not been demonstrated. In this study, we applied NAD(P)H FLIM to map the metabolic profiles of Drosophila neurons in vivo across multiple scales, focusing on the primary centers for associative memory: the mushroom bodies (MBs). At a broad scale, we obtained an overview of the metabolic signatures of the main brain tissue and identified a marked difference between neuropil and cortex areas. At a finer scale, our findings revealed notable heterogeneity in the basal metabolic profiles of distinct MB neuron subtypes. Measurements performed after associative olfactory learning also uncovered a low-magnitude subtype-specific metabolic shift associated with memory formation, suggesting the utility of NAD(P)H FLIM in detecting physiology-driven changes linked to brain function. These results establish a promising framework for studying the spatial heterogeneities and the dynamics of cerebral energy metabolism in vivo.", "subject": null, "language": null, "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1364/prj.462578", "doi": "10.1364/prj.462578", "title": "Speckle spatial correlations aiding optical transmission matrix retrieval: the smoothed Gerchberg–Saxton single-iteration algorithm", "publicationYear": 2022, "publicationDate": "2022-10-01", "type": "journal-article", "publisher": "Optica Publishing Group", "containerTitle": "Photonics Research", "volume": "10", "issue": "10", "page": "2349", "issn": "2327-9125", "isbn": null, "authors": "Daniele Ancora, Lorenzo Dominici, Antonio Gianfrate, Paolo Cazzato, Milena De Giorgi, Dario Ballarini, Daniele Sanvitto, Luca Leuzzi", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 18, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": null, "funderNames": "Lazio Innova, European Research Council", "funderIds": "10.13039/100019470, 10.13039/501100000781", "url": "https://doi.org/10.1364/prj.462578", "pdfUrl": null, "abstract": "The estimation of the transmission matrix of a disordered medium is a challenging problem in disordered photonics. Usually, its reconstruction relies on a complex inversion that aims at connecting a fully controlled input to the deterministic interference of the light field scrambled by the device. At the moment, iterative phase retrieval protocols provide the fastest reconstructing frameworks, converging in a few tens of iterations. Exploiting the knowledge of speckle correlations, we construct a new phase retrieval algorithm that reduces the computational cost to a single iteration. Besides being faster, our method is practical because it accepts fewer measurements than state-of-the-art protocols. Thanks to reducing computation time by one order of magnitude, our result can be a step forward toward real-time optical imaging that exploits disordered devices.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1109/lwc.2021.3099136", "doi": "10.1109/lwc.2021.3099136", "title": "Federated mmWave Beam Selection Utilizing LIDAR Data", "publicationYear": 2021, "publicationDate": "2021-10", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Wireless Communications Letters", "volume": "10", "issue": "10", "page": "2269-2273", "issn": "2162-2337, 2162-2345", "isbn": null, "authors": "Mahdi Boloursaz Mashhadi, Mikolaj Jankowski, Tze-Yang Tung, Szymon Kobus, Deniz Gunduz", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 67, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": "European Research Council, Engineering and Physical Sciences Research Council", "funderIds": "10.13039/501100000781, 10.13039/501100000266", "url": "https://doi.org/10.1109/lwc.2021.3099136", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.3390/math10030442", "doi": "10.3390/math10030442", "title": "Partial Exchangeability for Contingency Tables", "publicationYear": 2022, "publicationDate": "2022-01-29", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Mathematics", "volume": "10", "issue": "3", "page": "442", "issn": "2227-7390", "isbn": null, "authors": "Persi Diaconis", "authorCount": 1, "firstAuthorAffiliation": "Department of Mathematics and Statistics, Sequoia Hall, Stanford University, Stanford, CA 94305, USA", "isReferencedByCount": 4, "referenceCount": 28, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.3390/math10030442", "pdfUrl": null, "abstract": "A parameter free version of classical models for contingency tables is developed along the lines of de Finetti’s notions of partial exchangeability.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1021/acsbiomaterials.4c00819", "doi": "10.1021/acsbiomaterials.4c00819", "title": "Rapidly Degrading Hydrogels to Support Biofabrication and 3D Bioprinting Using Cartilage Microtissues", "publicationYear": 2024, "publicationDate": "2024-10-14", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "ACS Biomaterials Science &amp; Engineering", "volume": "10", "issue": "10", "page": "6441-6450", "issn": "2373-9878, 2373-9878", "isbn": null, "authors": "Gabriela S. Kronemberger, Francesca D. Spagnuolo, Aliaa S. Karam, Kaoutar Chattahy, Kyle J. Storey, Daniel J. Kelly", "authorCount": 6, "firstAuthorAffiliation": "Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin D02 R590, Ireland", "isReferencedByCount": 15, "referenceCount": 52, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.1021/acsbiomaterials.4c00819", "pdfUrl": "https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.4c00819", "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1002/advs.202205487", "doi": "10.1002/advs.202205487", "title": "Steering Stem Cell Fate within 3D Living Composite Tissues Using Stimuli‐Responsive Cell‐Adhesive Micromaterials", "publicationYear": 2023, "publicationDate": "2023-04", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Advanced Science", "volume": "10", "issue": "10", "page": null, "issn": "2198-3844, 2198-3844", "isbn": null, "authors": "Tom Kamperman, Niels G. A. Willemen, Cindy Kelder, Michelle Koerselman, Malin Becker, Luanda Lins, Castro Johnbosco, Marcel Karperien, Jeroen Leijten", "authorCount": 9, "firstAuthorAffiliation": "Department of Developmental BioEngineering Faculty of Science and Technology Technical Medical Centre University of Twente  Drienerlolaan 5 Enschede 7522NB The Netherlands", "isReferencedByCount": 25, "referenceCount": 90, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.1002/advs.202205487", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202205487", "abstract": "AbstractEngineered living microtissues such as cellular spheroids and organoids have enormous potential for the study and regeneration of tissues and organs. Microtissues are typically engineered via self‐assembly of adherent cells into cellular spheroids, which are characterized by little to no cell–material interactions. Consequently, 3D microtissue models currently lack structural biomechanical and biochemical control over their internal microenvironment resulting in suboptimal functional performance such as limited stem cell differentiation potential. Here, this work report on stimuli‐responsive cell‐adhesive micromaterials (SCMs) that can self‐assemble with cells into 3D living composite microtissues through integrin binding, even under serum‐free conditions. It is demonstrated that SCMs homogeneously distribute within engineered microtissues and act as biomechanically and biochemically tunable designer materials that can alter the composite tissue microenvironment on demand. Specifically, cell behavior is controlled based on the size, stiffness, number ratio, and biofunctionalization of SCMs in a temporal manner via orthogonal secondary crosslinking strategies. Photo‐based mechanical tuning of SCMs reveals early onset stiffness‐controlled lineage commitment of differentiating stem cell spheroids. In contrast to conventional encapsulation of stem cell spheroids within bulk hydrogel, incorporating cell‐sized SCMs within stem cell spheroids uniquely provides biomechanical cues throughout the composite microtissues’ volume, which is demonstrated to be essential for osteogenic differentiation.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.21468/scipostphys.10.3.056", "doi": "10.21468/scipostphys.10.3.056", "title": "Entanglement gap, corners, and symmetry breaking", "publicationYear": 2021, "publicationDate": "2021-03-08", "type": "journal-article", "publisher": "Stichting SciPost", "containerTitle": "SciPost Physics", "volume": "10", "issue": "3", "page": null, "issn": "2542-4653", "isbn": null, "authors": "Vincenzo Alba", "authorCount": 1, "firstAuthorAffiliation": "Institute of Physics, University of Amsterdam", "isReferencedByCount": 6, "referenceCount": 74, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.21468/scipostphys.10.3.056", "pdfUrl": "https://scipost.org/10.21468/SciPostPhys.10.3.056/pdf", "abstract": "We investigate the finite-size scaling of the lowest entanglement gap \\delta\\xi δ ξ in the ordered phase of the two-dimensional quantum spherical model (QSM). The entanglement gap decays as \\delta\\xi=\\Omega/\\sqrt{L\\ln(L)} δ ξ = Ω / L ln ( L ) . This is in contrast with the purely logarithmic behaviour as \\delta\\xi=\\pi^2/\\ln(L) δ ξ = π 2 / ln ( L ) at the critical point. The faster decay in the ordered phase reflects the presence of magnetic order. We analytically determine the constant \\Omega Ω , which depends on the low-energy part of the model dispersion and on the geometry of the bipartition. In particular, we are able to compute the corner contribution to \\Omega Ω , at least for the case of a square corner.", "subject": null, "language": null, "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1016/j.str.2021.04.009", "doi": "10.1016/j.str.2021.04.009", "title": "Architecture and assembly dynamics of the essential mitochondrial chaperone complex TIM9·10·12", "publicationYear": 2021, "publicationDate": "2021-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Structure", "volume": "29", "issue": "9", "page": "1065-1073.e4", "issn": "0969-2126", "isbn": null, "authors": "Katharina Weinhäupl, Yong Wang, Audrey Hessel, Martha Brennich, Kresten Lindorff-Larsen, Paul Schanda", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 23, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Lundbeckfonden, European Research Council, French Infrastructure for Integrated Structural Biology, European Research Council, Agence nationale de la recherche, Agence nationale de la recherche, Agence nationale de la recherche", "funderIds": "10.13039/501100003554, 10.13039/100010663, 10.13039/501100011658, 10.13039/501100000781, 10.13039/501100001665, 10.13039/501100001665, 10.13039/501100001665", "url": "https://doi.org/10.1016/j.str.2021.04.009", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1007/s00285-022-01798-0", "doi": "10.1007/s00285-022-01798-0", "title": "Stoechiometric and dynamical autocatalysis for diluted chemical reaction networks", "publicationYear": 2022, "publicationDate": "2022-09", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Journal of Mathematical Biology", "volume": "85", "issue": "3", "page": null, "issn": "0303-6812, 1432-1416", "isbn": null, "authors": "Jérémie Unterberger, Philippe Nghe", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 11, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": "European Research Council, Fondation Pierre-Gilles de Gennes pour la recherche, Fondation Pierre-Gilles de Gennes pour la recherche", "funderIds": "10.13039/501100000781, 10.13039/501100009627, 10.13039/501100009627", "url": "https://doi.org/10.1007/s00285-022-01798-0", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s00285-022-01798-0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1016/j.ekir.2025.07.019", "doi": "10.1016/j.ekir.2025.07.019", "title": "Elucidating Mechanisms of Hypomorphic WDR19-Related Kidney Failure", "publicationYear": 2025, "publicationDate": "2025-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Kidney International Reports", "volume": "10", "issue": "10", "page": "3578-3591", "issn": "2468-0249", "isbn": null, "authors": "Omer Shlomovitz, Yam Ben-Haim, Netanel Eisenstein, Leah Armon, Igor Grinberg, Sylvie Polak-Charcon, Danit Atias-Varon, Guy Chowers, Dror Ben-Ruby, Achia Urbach, Asaf Vivante", "authorCount": 11, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "ISF, ERC, Tel Aviv University, European Research Council", "funderIds": "10.13039/501100003977, 10.13039/100010663, 10.13039/501100004375, 10.13039/501100000781", "url": "https://doi.org/10.1016/j.ekir.2025.07.019", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1016/j.ejim.2021.01.023", "doi": "10.1016/j.ejim.2021.01.023", "title": "Sweet taste and obesity", "publicationYear": 2021, "publicationDate": "2021-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "European Journal of Internal Medicine", "volume": "92", "issue": null, "page": "3-10", "issn": "0953-6205", "isbn": null, "authors": "Gabriela Ribeiro, Albino J. Oliveira-Maia", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 41, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Fundação para a Ciência e a Tecnologia, Fundação Bial, Universidade de Lisboa, Horizon 2020, European Research Council, Horizon 2020 Framework Programme", "funderIds": "10.13039/501100001871, 10.13039/501100005032, 10.13039/501100005765, 10.13039/501100007601, 10.13039/501100000781, 10.13039/100010661", "url": "https://doi.org/10.1016/j.ejim.2021.01.023", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1128/msystems.00732-25", "doi": "10.1128/msystems.00732-25", "title": "Metabolic response of a chemolithoautotrophic archaeon to carbon limitation", "publicationYear": 2025, "publicationDate": "2025-10-22", "type": "journal-article", "publisher": "American Society for Microbiology", "containerTitle": "mSystems", "volume": "10", "issue": "10", "page": null, "issn": "2379-5077", "isbn": null, "authors": "Logan H. Hodgskiss, Melina Kerou, Zhen-Hao Luo, Barbara Bayer, Andreas Maier, Wolfram Weckwerth, Thomas Nägele, Christa Schleper", "authorCount": 8, "firstAuthorAffiliation": "Department of Functional and Evolutionary Ecology, Archaea Biology and Ecogenomics Unit, University of Vienna", "isReferencedByCount": 0, "referenceCount": 77, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Austrian Science Fund, European Research Council, PRIORITY 'Excellent science'", "funderIds": "10.13039/501100002428, 10.13039/501100000781, 10.13039/100010662", "url": "https://doi.org/10.1128/msystems.00732-25", "pdfUrl": "https://journals.asm.org/doi/pdf/10.1128/msystems.00732-25", "abstract": "ABSTRACT The ubiquitously distributed ammonia-oxidizing archaea generate energy from ammonia and build cell mass from inorganic carbon sources, thereby contributing to both the global nitrogen and carbon cycles. However, little is known about the regulation of their predicted core carbon metabolism. A thermodynamic model for Nitrososphaera viennensis was developed to estimate the consumption of inorganic carbon in relation to ammonia consumed for energy and was tested experimentally by growing cells in carbon-limited and excess conditions. A combined proteomic and metabolomic approach to the experimental conditions revealed distinct metabolic adaptation depending on the amount of carbon supplied, either in a catalase or pyruvate background as a reactive oxygen species scavenger. Integration of protein and metabolite dynamics revealed a cellular strategy under carbon limitation to maintain a pool of amino acids and an upregulation of proteins necessary for translation initiation to stay primed for protein synthesis. The combination of modeling and functional genomics fills gaps in the understanding of the central metabolism and its regulation in a chemolithoautotrophic, ammonia-oxidizing archaeon, even in the absence of available genetic tools. IMPORTANCE Little is known about the regulation of carbon metabolism within ammonia-oxidizing archaea (AOA), a widespread clade that plays a critical role in the global nitrogen cycle while also fixing inorganic carbon. To address this missing knowledge, the soil AOA Nitrososphaera viennensis was subjected to various levels of inorganic carbon and analyzed via a systems biology approach to better understand how its core metabolism is regulated. The results demonstrate a strong dependence on the carbon fixation cycle and highlight key connection points between the core metabolic pathways. The analysis additionally revealed tight control on translational processes and elucidated unique cellular responses when the organism was exposed to either exogenous catalase or pyruvate to relieve oxidative stress from reactive oxygen species. The presented data highlight metabolic responses of N. viennensis and provide a better understanding of how the organism, and likely other AOA, respond to various environmental conditions.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1017/s0033291724001880", "doi": "10.1017/s0033291724001880", "title": "Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts", "publicationYear": 2024, "publicationDate": "2024-09", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Psychological Medicine", "volume": "54", "issue": "12", "page": "3459-3468", "issn": "0033-2917, 1469-8978", "isbn": null, "authors": "Mark J. Adams, Jackson G. Thorp, Bradley S. Jermy, Alex S. F. Kwong, Kadri Kõiv, Andrew D. Grotzinger, Michel G. Nivard, Sally Marshall, Yuri Milaneschi, Bernhard T. Baune, Bertram Müller-Myhsok, Brenda W. J. H. Penninx, Dorret I. Boomsma, Douglas F. Levinson, Gerome Breen, Giorgio Pistis, Hans J. Grabe, Henning Tiemeier, Klaus Berger, Marcella Rietschel, Patrik K. Magnusson, Rudolf Uher, Steven P. Hamilton, Susanne Lucae, Kelli Lehto, Qingqin S. Li, Enda M. Byrne, Ian B. Hickie, Nicholas G. Martin, Sarah E Medland, Naomi R. Wray, Elliot M. Tucker-Drob, Estonian Biobank Research Team, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Cathryn M. Lewis, Andrew M McIntosh, Eske M. Derks", "authorCount": 37, "firstAuthorAffiliation": "Division of Psychiatry, University of Edinburgh", "isReferencedByCount": 25, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Institutes of Health, Medical Research Council, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Eesti Teadusagentuur, Wellcome Trust, European Research Council, National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care North West Coast", "funderIds": "10.13039/100000002, 10.13039/501100000265, 10.13039/501100003246, 10.13039/501100002301, 10.13039/100010269, 10.13039/501100000781, 10.13039/501100015509", "url": "https://doi.org/10.1017/s0033291724001880", "pdfUrl": null, "abstract": "AbstractBackgroundDiagnostic criteria for major depressive disorder allow for heterogeneous symptom profiles but genetic analysis of major depressive symptoms has the potential to identify clinical and etiological subtypes. There are several challenges to integrating symptom data from genetically informative cohorts, such as sample size differences between clinical and community cohorts and various patterns of missing data.MethodsWe conducted genome-wide association studies of major depressive symptoms in three cohorts that were enriched for participants with a diagnosis of depression (Psychiatric Genomics Consortium, Australian Genetics of Depression Study, Generation Scotland) and three community cohorts who were not recruited on the basis of diagnosis (Avon Longitudinal Study of Parents and Children, Estonian Biobank, and UK Biobank). We fit a series of confirmatory factor models with factors that accounted for how symptom data was sampled and then compared alternative models with different symptom factors.ResultsThe best fitting model had a distinct factor for Appetite/Weight symptoms and an additional measurement factor that accounted for the skip-structure in community cohorts (use of Depression and Anhedonia as gating symptoms).ConclusionThe results show the importance of assessing the directionality of symptoms (such as hypersomnia versus insomnia) and of accounting for study and measurement design when meta-analyzing genetic association data.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1093/stcltm/szac064", "doi": "10.1093/stcltm/szac064", "title": "CRISPRthripsis: The Risk of CRISPR/Cas9-induced Chromothripsis in Gene Therapy", "publicationYear": 2022, "publicationDate": "2022-10-21", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Stem Cells Translational Medicine", "volume": "11", "issue": "10", "page": "1003-1009", "issn": "2157-6564, 2157-6580", "isbn": null, "authors": "Mario Amendola, Mégane Brusson, Annarita Miccio", "authorCount": 3, "firstAuthorAffiliation": "Genethon , Evry , France", "isReferencedByCount": 44, "referenceCount": 71, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Agence Nationale de la Recherche under “Investissements d’avenir” program, “Appel à projets générique 2020”, European Research Council", "funderIds": "10.13039/501100000781", "url": "https://doi.org/10.1093/stcltm/szac064", "pdfUrl": "https://academic.oup.com/stcltm/article-pdf/11/10/1003/46593095/szac064.pdf", "abstract": "Abstract The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 nuclease system has allowed the generation of disease models and the development of therapeutic approaches for many genetic and non-genetic disorders. However, the generation of large genomic rearrangements has raised safety concerns for the clinical application of CRISPR/Cas9 nuclease approaches. Among these events, the formation of micronuclei and chromosome bridges due to chromosomal truncations can lead to massive genomic rearrangements localized to one or few chromosomes. This phenomenon, known as chromothripsis, was originally described in cancer cells, where it is believed to be caused by defective chromosome segregation during mitosis or DNA double-strand breaks. Here, we will discuss the factors influencing CRISPR/Cas9-induced chromothripsis, hereafter termed CRISPRthripsis, and its outcomes, the tools to characterize these events and strategies to minimize them.", "subject": null, "language": "en", "_run_id": "ZaXmG92iXjaQ2NvEa", "_dataset_id": "jbz6GUjW500cIFFrl"}
{"paperId": "10.1017/cbo9781139342100.008", "doi": "10.1017/cbo9781139342100.008", "title": "Metaphoric Reference: A Real-Time Analysis", "publicationYear": 2015, "publicationDate": "2015-01-26", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Bilingual Figurative Language Processing", "volume": null, "issue": null, "page": "89-116", "issn": null, "isbn": "9781107029545, 9781107609501, 9781139342100", "authors": "Roberto R. Heredia, Mónica E. Muñoz", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 12, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9781139342100.008", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/9781009586283.003", "doi": "10.1017/9781009586283.003", "title": "Sugar", "publicationYear": 2025, "publicationDate": "2025-05-31", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Fair Trade", "volume": null, "issue": null, "page": "43-68", "issn": null, "isbn": "9781009586283, 9781009586252, 9781009586269", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/9781009586283.003", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/9781139424721.006", "doi": "10.1017/9781139424721.006", "title": "Memories of Violence: Hama 1982", "publicationYear": 2018, "publicationDate": "2018-09-08", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "The Rule of Violence", "volume": null, "issue": null, "page": "131-158", "issn": null, "isbn": "9781139424721, 9781107032187, 9781107698604", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 264, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/9781139424721.006", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/9781316675847.002", "doi": "10.1017/9781316675847.002", "title": "Introduction", "publicationYear": 2018, "publicationDate": "2018-09-24", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Relational Egalitarianism", "volume": null, "issue": null, "page": "1-20", "issn": null, "isbn": "9781316675847, 9781107158900, 9781316613672", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 165, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/9781316675847.002", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
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{"paperId": "10.1017/cbo9781139540810.006", "doi": "10.1017/cbo9781139540810.006", "title": "EU primary law on services: fundamentals and delimitations", "publicationYear": 2014, "publicationDate": "2014-10-16", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Services Liberalization in the EU and the WTO", "volume": null, "issue": null, "page": "75-121", "issn": null, "isbn": "9781139540810, 9781107034594", "authors": "Marcus Klamert, Kathrin Blanck-Putz", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 53, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9781139540810.006", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/cbo9781107705609.001", "doi": "10.1017/cbo9781107705609.001", "title": "Introduction", "publicationYear": 2014, "publicationDate": "2014-10-09", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Public Participation and Legitimacy in the WTO", "volume": null, "issue": null, "page": "1-20", "issn": null, "isbn": "9781107705609, 9781107067820, 9781107660540", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 53, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9781107705609.001", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/9781009428514.019", "doi": "10.1017/9781009428514.019", "title": "Index", "publicationYear": 2025, "publicationDate": "2025-05-31", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Medicine on a Larger Scale", "volume": null, "issue": null, "page": "325-335", "issn": null, "isbn": "9781009428514, 9781009428569, 9781009428552", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/9781009428514.019", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/9781009220545.005", "doi": "10.1017/9781009220545.005", "title": "Logical Truth, Logical Consequence, and Explosions!", "publicationYear": 2025, "publicationDate": "2025-04-17", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Logic for Everyone", "volume": null, "issue": null, "page": "46-61", "issn": null, "isbn": "9781009220545, 9781009220538, 9781009220552", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/9781009220545.005", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
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{"paperId": "10.1017/9781009349994.011", "doi": "10.1017/9781009349994.011", "title": "Flag Varieties and Schubert Polynomials", "publicationYear": 2023, "publicationDate": "2023-10-26", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Equivariant Cohomology in Algebraic Geometry", "volume": null, "issue": null, "page": "152-181", "issn": null, "isbn": "9781009349994, 9781009349987, 9781009349970", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/9781009349994.011", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
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{"paperId": "10.1017/cco9781107587823.018", "doi": "10.1017/cco9781107587823.018", "title": "Reviewing", "publicationYear": 2015, "publicationDate": "2015-10-14", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "The Cambridge Companion to Victorian Women's Writing", "volume": null, "issue": null, "page": "236-250", "issn": null, "isbn": "9781107587823, 9781107064843, 9781107659612", "authors": "Joanne Wilkes", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 220, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cco9781107587823.018", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/9781009209038.018", "doi": "10.1017/9781009209038.018", "title": "Digital Business Models", "publicationYear": 2023, "publicationDate": "2023-12-21", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Digital Innovation Strategy", "volume": null, "issue": null, "page": "168-179", "issn": null, "isbn": "9781009209038, 9781009208987, 9781009209007", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 9, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/9781009209038.018", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/9781108918589.034", "doi": "10.1017/9781108918589.034", "title": "Persian Virtues", "publicationYear": 2023, "publicationDate": "2023-01-26", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Shakespeare and Virtue", "volume": null, "issue": null, "page": "300-305", "issn": null, "isbn": "9781108918589, 9781108843409, 9781108825047", "authors": "Sheiba Kian Kaufman", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/9781108918589.034", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/9781009488143.001", "doi": "10.1017/9781009488143.001", "title": "Introduction", "publicationYear": 2025, "publicationDate": "2025-04-03", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Politicians Manipulating Statistics", "volume": null, "issue": null, "page": "1-9", "issn": null, "isbn": "9781009488143, 9781009488136, 9781009488167", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/9781009488143.001", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/9781108973168.006", "doi": "10.1017/9781108973168.006", "title": "Advocacy and Activism", "publicationYear": 2025, "publicationDate": "2025-02-06", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Language Activism", "volume": null, "issue": null, "page": "75-92", "issn": null, "isbn": "9781108973168, 9781108833165, 9781108972819", "authors": "Elana Shohamy, Michal Tannenbaum", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/9781108973168.006", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/cbo9781139248884.004", "doi": "10.1017/cbo9781139248884.004", "title": "Supporting individual researchers", "publicationYear": 2015, "publicationDate": "2015-11-12", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "The Royal Society and the Promotion of Science since 1960", "volume": null, "issue": null, "page": "56-81", "issn": null, "isbn": "9781139248884, 9781107029262", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 31, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9781139248884.004", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/cbo9781316117293.005", "doi": "10.1017/cbo9781316117293.005", "title": "Laws", "publicationYear": 2015, "publicationDate": "2015-10-20", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Frontier Democracy", "volume": null, "issue": null, "page": "108-141", "issn": null, "isbn": "9781316117293, 9781107090767, 9781107462892", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 109, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9781316117293.005", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/cco9780511795008.015", "doi": "10.1017/cco9780511795008.015", "title": "Petrarch and the ancients", "publicationYear": 2015, "publicationDate": "2015-10-31", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "The Cambridge Companion to Petrarch", "volume": null, "issue": null, "page": "141-153", "issn": null, "isbn": "9780511795008, 9781107006140, 9780521185042", "authors": "Gur Zak", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 280, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cco9780511795008.015", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/cco9780511795008.002", "doi": "10.1017/cco9780511795008.002", "title": "Introduction", "publicationYear": 2015, "publicationDate": "2015-10-31", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "The Cambridge Companion to Petrarch", "volume": null, "issue": null, "page": "1-10", "issn": null, "isbn": "9780511795008, 9781107006140, 9780521185042", "authors": "Albert Russell Ascoli, Unn Falkeid", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 272, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cco9780511795008.002", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/cbo9781139034210.006", "doi": "10.1017/cbo9781139034210.006", "title": "The misbegotten: long lineages, long branches and the interrelationships of <i>Aotus</i>, <i>Callicebus</i> and the saki–uacaris*", "publicationYear": 2013, "publicationDate": "2013-04-11", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Evolutionary Biology and Conservation of Titis, Sakis and Uacaris", "volume": null, "issue": null, "page": "13-22", "issn": null, "isbn": null, "authors": "Alfred L. Rosenberger, Marcelo F. Tejedor", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 19, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9781139034210.006", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/cbo9781316026991.005", "doi": "10.1017/cbo9781316026991.005", "title": "The archaeological record", "publicationYear": 2015, "publicationDate": "2015-09-03", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Ancient China and the Yue", "volume": null, "issue": null, "page": "62-82", "issn": null, "isbn": "9781316026991, 9781107084780, 9781107446816", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 31, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9781316026991.005", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/cho9781139048781.029", "doi": "10.1017/cho9781139048781.029", "title": "The Bible and the emerging ‘scientific’ world-view", "publicationYear": 2016, "publicationDate": "2016-03-28", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "The New Cambridge History of the Bible", "volume": null, "issue": null, "page": "620-640", "issn": null, "isbn": "9780521513425, 9781139048781", "authors": "Peter Harrison", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 1503, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cho9781139048781.029", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1017/cbo9781107110632.004", "doi": "10.1017/cbo9781107110632.004", "title": "Toward a General Scaling Theory for Linking Traits, Stoichiometry, and Body Size to Ecosystem Function", "publicationYear": 2016, "publicationDate": "2016-09-30", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "A Biogeoscience Approach to Ecosystems", "volume": null, "issue": null, "page": "9-46", "issn": null, "isbn": null, "authors": "Brian J. Enquist, Sean T. Michaletz, Andrew J. Kerkhoff", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 101, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9781107110632.004", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "89a9jJzheDEHq96Ue", "_dataset_id": "lfwIivH7pQSclL5Kk"}
{"paperId": "10.1002/acn3.249", "doi": "10.1002/acn3.249", "title": "Interobserver agreement for neonatal seizure detection using multichannel <scp>EEG</scp>", "publicationYear": 2015, "publicationDate": "2015-11", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Annals of Clinical and Translational Neurology", "volume": "2", "issue": "11", "page": "1002-1011", "issn": "2328-9503, 2328-9503", "isbn": null, "authors": "Nathan J. Stevenson, Robert R. Clancy, Sampsa Vanhatalo, Ingmar Rosén, Janet M. Rennie, Geraldine B. Boylan", "authorCount": 6, "firstAuthorAffiliation": "Neonatal Brain Research Group Irish Centre for Fetal and Neonatal Translational Research University College Cork Cork Ireland", "isReferencedByCount": 53, "referenceCount": 26, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust UK, Wellcome Trust UK, Science Foundation Ireland, Science Foundation Ireland, Science Foundation Ireland, Children's Hospital of Philadelphia Endowed Chair in Pediatric Neurology Research, Topiramate Research Fund, Finnish Academy, Sigrid Juselius Foundation", "funderIds": "10.13039/100010269, 10.13039/100010269, 10.13039/501100001602, 10.13039/501100001602, 10.13039/501100001602, 10.13039/501100002341", "url": "https://doi.org/10.1002/acn3.249", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/acn3.249", "abstract": "AbstractObjectiveTo determine the interobserver agreement (IOA) of neonatal seizure detection using the gold standard of conventional, multichannel EEG.MethodsA cohort of full‐term neonates at risk of acute encephalopathy was included in this prospective study. The EEG recordings of these neonates were independently reviewed for seizures by three international experts. The IOA was estimated using statistical measures including Fleiss' kappa and percentage agreement assessed over seizure events (event basis) and seizure duration (temporal basis).ResultsA total of 4066 h of EEG recordings from 70 neonates were reviewed with an average of 2555 seizures detected. The IOA was high with temporal assessment resulting in a kappa of 0.827 (95% CI: 0.769–0.865; n = 70). The median agreement was 83.0% (interquartile range [IQR]: 76.6–89.5%; n = 33) for seizure and 99.7% (IQR: 98.9–99.8%; n = 70) for nonseizure EEG. Analysis of events showed a median agreement of 83.0% (IQR: 72.9–86.6%; n = 33) for seizures with 0.018 disagreements per hour (IQR: 0.000–0.090 per hour; n = 70). Observers were more likely to disagree when a seizure was less than 30 sec. Overall, 33 neonates were diagnosed with seizures and 28 neonates were not, by all three observers. Of the remaining nine neonates with contradictory EEG detections, seven presented with low total seizure burden.InterpretationThe IOA is high among experts for the detection of neonatal seizures using conventional, multichannel EEG. Agreement is reduced when seizures are rare or have short duration. These findings support EEG‐based decision making in the neonatal intensive care unit, inform EEG interpretation guidelines, and provide benchmarks for seizure detection algorithms.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1007/s00395-023-01002-4", "doi": "10.1007/s00395-023-01002-4", "title": "Preventing mitochondrial reverse electron transport as a strategy for cardioprotection", "publicationYear": 2023, "publicationDate": "2023-08-28", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Basic Research in Cardiology", "volume": "118", "issue": "1", "page": null, "issn": "1435-1803", "isbn": null, "authors": "Hiran A. Prag, Michael P. Murphy, Thomas Krieg", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 44, "referenceCount": 178, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "British Heart Foundation, Medical Research Council, Wellcome Trust", "funderIds": "10.13039/501100000274, 10.13039/501100000265, 10.13039/100010269", "url": "https://doi.org/10.1007/s00395-023-01002-4", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s00395-023-01002-4.pdf", "abstract": "AbstractIn the context of myocardial infarction, the burst of superoxide generated by reverse electron transport (RET) at complex I in mitochondria is a crucial trigger for damage during ischaemia/reperfusion (I/R) injury. Here we outline the necessary conditions for superoxide production by RET at complex I and how it can occur during reperfusion. In addition, we explore various pathways that are implicated in generating the conditions for RET to occur and suggest potential therapeutic strategies to target RET, aiming to achieve cardioprotection.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1039/d4cb00093e", "doi": "10.1039/d4cb00093e", "title": "Expanding the repertoire of GalNAc analogues for cell-specific bioorthogonal tagging of glycoproteins", "publicationYear": 2024, "publicationDate": "2024", "type": "journal-article", "publisher": "Royal Society of Chemistry (RSC)", "containerTitle": "RSC Chemical Biology", "volume": "5", "issue": "10", "page": "1002-1009", "issn": "2633-0679", "isbn": null, "authors": "Abdul Zafar, Sandhya Sridhar, Ganka Bineva-Todd, Anna Cioce, Nadia Abdulla, Vincent Chang, Stacy A. Malaker, David S. Hewings, Benjamin Schumann", "authorCount": 9, "firstAuthorAffiliation": "Chemical Glycobiology Laboratory, The Francis Crick Institute, NW1 1AT London, UK", "isReferencedByCount": 8, "referenceCount": 36, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/3.0/", "funderNames": "Biotechnology and Biological Sciences Research Council, Biotechnology and Biological Sciences Research Council, Medical Research Council, Cancer Research UK, Cancer Research UK, Wellcome Trust, Engineering and Physical Sciences Research Council, National Institute of General Medical Sciences, National Science Foundation", "funderIds": "10.13039/501100000268, 10.13039/501100000268, 10.13039/501100000265, 10.13039/501100000289, 10.13039/501100000289, 10.13039/100010269, 10.13039/501100000266, 10.13039/100000057, 10.13039/100000001", "url": "https://doi.org/10.1039/d4cb00093e", "pdfUrl": "http://pubs.rsc.org/en/content/articlepdf/2024/CB/D4CB00093E", "abstract": "Demonstrating the use of azide-containing GalNAc analogues in conjunction with an engineered metabolic pathway to study glycosylation cell-specifically.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1111/bcp.16006", "doi": "10.1111/bcp.16006", "title": "Physiologically‐based pharmacokinetic modelling of long‐acting injectable cabotegravir and rilpivirine in pregnancy", "publicationYear": 2025, "publicationDate": "2025-04", "type": "journal-article", "publisher": "Wiley", "containerTitle": "British Journal of Clinical Pharmacology", "volume": "91", "issue": "4", "page": "989-1002", "issn": "0306-5251, 1365-2125", "isbn": null, "authors": "Shakir Atoyebi, Fazila Bunglawala, Nicolas Cottura, Sandra Grañana‐Castillo, Maiara Camotti Montanha, Adeniyi Olagunju, Marco Siccardi, Catriona Waitt", "authorCount": 8, "firstAuthorAffiliation": "University of Liverpool  Liverpool UK", "isReferencedByCount": 25, "referenceCount": 67, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.1111/bcp.16006", "pdfUrl": null, "abstract": "AimsLong‐acting cabotegravir and rilpivirine have been approved to manage HIV in adults, but data regarding safe use in pregnancy are limited. Physiologically‐based pharmacokinetic (PBPK) modelling was used to simulate the approved dosing regimens in pregnancy and explore if Ctrough was maintained above cabotegravir and rilpivirine target concentrations (664 and 50 ng/mL, respectively).MethodsAn adult PBPK model was validated using clinical data of cabotegravir and rilpivirine in nonpregnant adults. This was modified by incorporating pregnancy‐induced metabolic and physiological changes. The pregnancy PBPK model was validated with data on oral rilpivirine and raltegravir (UGT1A1 probe substrate) in pregnancy. Twelve weeks' disposition of monthly and bimonthly dosing of long‐acting cabotegravir and rilpivirine was simulated at different trimesters and foetal exposure was also estimated.ResultsPredicted Ctrough at week 12 for monthly long‐acting cabotegravir was above 664 ng/mL throughout pregnancy, but below the target in 0.5% of the pregnant population in the third trimester with bimonthly long‐acting cabotegravir. Predicted Ctrough at week 12 for monthly and bimonthly long‐acting rilpivirine was below 50 ng/mL in at least 40% and over 90% of the pregnant population, respectively, throughout pregnancy. Predicted medians (range) of cord‐to‐maternal blood ratios were 1.71 (range, 1.55‐1.79) for cabotegravir and 0.88 (0.78‐0.93) for rilpivirine between weeks 38 and 40.ConclusionsModel predictions suggest that monthly long‐acting cabotegravir could maintain antiviral efficacy throughout pregnancy, but that bimonthly administration may require careful clinical evaluation. Both monthly and bimonthly long‐acting rilpivirine may not adequately maintain antiviral efficacy in pregnancy.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1186/s13550-023-01002-4", "doi": "10.1186/s13550-023-01002-4", "title": "Inter-rater and intra-rater agreement of [99mTc]-labelled NM-01, a single-domain programmed death-ligand 1 (PD-L1) antibody, using quantitative SPECT/CT in non-small cell lung cancer", "publicationYear": 2023, "publicationDate": "2023-05-31", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "EJNMMI Research", "volume": "13", "issue": "1", "page": null, "issn": "2191-219X", "isbn": null, "authors": "Daniel Johnathan Hughes, Gitasha Chand, Jessica Johnson, Damion Bailey, Kathryn Adamson, Vicky Goh, Gary J. R. Cook", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 19, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "Cancer Research UK, Wellcome Trust", "funderIds": "10.13039/501100000289, 10.13039/100010269", "url": "https://doi.org/10.1186/s13550-023-01002-4", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s13550-023-01002-4.pdf", "abstract": "Abstract Background Immune checkpoint inhibitors, including those against programmed cell death protein-1 (PD-1) or its ligand (PD-L1), are routinely used to treat non-small cell lung cancer (NSCLC). PD-L1 is a validated prognostic and predictive immunohistochemical biomarker of anti-PD-1/PD-L1 therapy but displays temporospatial heterogeneity of expression. Non-invasive radiopharmaceutical techniques, including technetium-99m [99mTc]-labelled anti-PD-L1 single-domain antibody (NM-01) SPECT/CT, have the potential to improve the predictive value of PD-L1 assessment. This study aims to determine the inter- and intra-rater agreement of the quantitative measurement of [99mTc]NM-01 SPECT/CT in NSCLC. Methods Participants (n = 14) with untreated advanced NSCLC underwent [99mTc]NM-01 SPECT/CT at baseline (n = 3) or at baseline plus 9-week follow-up (n = 11). [99mTc]NM-01 uptake (of primary lung, lymph node, thoracic and distant metastases, and healthy reference tissues) was measured using SUVmax and malignant lesion-to-blood pool ratios with Siemens xSPECT Broad Quantification software by three independent raters. Intraclass correlation coefficients (ICC) were calculated and Bland–Altman plot analysis performed to determine inter- and intra-rater agreement. Results There was excellent inter-rater agreement of manual freehand SUVmax scores of primary lung tumour (T; n = 25; ICC 1.00; 95% CI 0.99–1.00), individual lymph node metastases (LN; n = 56; ICC 0.97; 95% CI 0.95–0.98), thoracic metastases (ThMet; n = 9; ICC 0.94; 95% CI 0.83–0.99) and distant metastases (DisMet; n = 21; ICC 0.91; 95% CI 0.83–0.96). The inter-rater ICCs of tumour-to-blood pool (T:BP), LN:BP, ThMet:BP and DisMet:BP measures of [99mTc]NM-01 uptake also demonstrated good or excellent agreement. Manual freehand scoring of T, LN, ThMet, DisMet and their ratios using [99mTc]NM-01 SPECT/CT following a 28-day interval was consistent for all raters with good or excellent intra-rater agreement demonstrated (ICCs range 0.86–1.00). Conclusion Quantitative assessment of [99mTc]NM-01 SPECT/CT in NSCLC, using SUVmax of malignant primary or metastatic lesions and their ratios with healthy reference tissues, demonstrated good or excellent inter- and intra-rater agreement in this study. Further validation with ongoing and future larger cohort studies is now warranted. Clinical trial registration ClinicalTrials.gov identifier no. NCT04436406 (registered 18th June 2020; available at https://clinicaltrials.gov/ct2/show/NCT04436406) and NCT04992715 (registered 5th August 2021; available at https://clinicaltrials.gov/ct2/show/NCT04992715).", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1093/braincomms/fcab072", "doi": "10.1093/braincomms/fcab072", "title": "The use of simultaneous stereo-electroencephalography and magnetoencephalography in localizing the epileptogenic focus in refractory focal epilepsy", "publicationYear": 2021, "publicationDate": "2021-04-05", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Brain Communications", "volume": "3", "issue": "2", "page": null, "issn": "2632-1297", "isbn": null, "authors": "Umesh Vivekananda, Chunyan Cao, Wei Liu, Jing Zhang, Fergus Rugg-Gunn, Matthew C Walker, Vladimir Litvak, Bomin Sun, Shikun Zhan", "authorCount": 9, "firstAuthorAffiliation": "Department of Clinical and Experimental Epilepsy, UCL, Queen Square Institute of Neurology, London WC1N 3BG, UK", "isReferencedByCount": 13, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Institute of Health Research, Epilepsy Research UK, Medical Research Council, Academy Medical Sciences, Wellcome Trust, National Natural Science Foundation of China", "funderIds": "10.13039/501100000265, 10.13039/100010269, 10.13039/501100001809", "url": "https://doi.org/10.1093/braincomms/fcab072", "pdfUrl": "http://academic.oup.com/braincomms/advance-article-pdf/doi/10.1093/braincomms/fcab072/36994367/fcab072.pdf", "abstract": "Abstract Both magnetoencephalography and stereo-electroencephalography are used in presurgical epilepsy assessment, with contrasting advantages and limitations. It is not known whether simultaneous stereo-electroencephalography–magnetoencephalography recording confers an advantage over both individual modalities, in particular whether magnetoencephalography can provide spatial context to epileptiform activity seen on stereo-electroencephalography. Twenty-four adult and paediatric patients who underwent stereo-electroencephalography study for pre-surgical evaluation of drug-resistant focal epilepsy, were recorded using simultaneous stereo-electroencephalography–magnetoencephalography, of which 14 had abnormal interictal activity during recording. The 14 patients were divided into two groups; those with detected superficial (n = 7) and deep (n = 7) brain interictal activity. Interictal spikes were independently identified in stereo-electroencephalography and magnetoencephalography. Magnetoencephalography dipoles were derived using a distributed inverse method. There was no significant difference between stereo-electroencephalography and magnetoencephalography in detecting superficial spikes (P = 0.135) and stereo-electroencephalography was significantly better at detecting deep spikes (P = 0.002). Mean distance across patients between stereo-electroencephalography channel with highest average spike amplitude and magnetoencephalography dipole was 20.7 ± 4.4 mm. for superficial sources, and 17.8 ± 3.7 mm. for deep sources, even though for some of the latter (n = 4) no magnetoencephalography spikes were detected and magnetoencephalography dipole was fitted to a stereo-electroencephalography interictal activity triggered average. Removal of magnetoencephalography dipole was associated with 1 year seizure freedom in 6/7 patients with superficial source, and 5/6 patients with deep source. Although stereo-electroencephalography has greater sensitivity in identifying interictal activity from deeper sources, a magnetoencephalography source can be localized using stereo-electroencephalography information, thereby providing useful whole brain context to stereo-electroencephalography and potential role in epilepsy surgery planning.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.3390/v12091002", "doi": "10.3390/v12091002", "title": "Defining New Pathways to Manage the Ongoing Emergence of Bat Rabies in Latin America", "publicationYear": 2020, "publicationDate": "2020-09-08", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Viruses", "volume": "12", "issue": "9", "page": "1002", "issn": "1999-4915", "isbn": null, "authors": "Julio A. Benavides, William Valderrama, Sergio Recuenco, Wilson Uieda, Gerardo Suzán, Rafael Avila-Flores, Andres Velasco-Villa, Marilene Almeida, Fernanda A.G. de Andrade, Baldomero Molina-Flores, Marco Antonio Natal Vigilato, Julio Cesar Augusto Pompei, Paolo Tizzani, Jorge E. Carrera, Darcy Ibanez, Daniel G. Streicker", "authorCount": 16, "firstAuthorAffiliation": "Departamento de Ecología y Biodiversidad, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370146, Chile", "isReferencedByCount": 62, "referenceCount": 81, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.3390/v12091002", "pdfUrl": null, "abstract": "Rabies transmitted by common vampire bats (Desmodus rotundus) has been known since the early 1900s but continues to expand geographically and in the range of species and environments affected. In this review, we present current knowledge of the epidemiology and management of rabies in D. rotundus and argue that it can be reasonably considered an emerging public health threat. We identify knowledge gaps related to the landscape determinants of the bat reservoir, reduction in bites on humans and livestock, and social barriers to prevention. We discuss how new technologies including autonomously-spreading vaccines and reproductive suppressants targeting bats might manage both rabies and undesirable growth of D. rotundus populations. Finally, we highlight widespread under-reporting of human and animal mortality and the scarcity of studies that quantify the efficacy of control measures such as bat culling. Collaborations between researchers and managers will be crucial to implement the next generation of rabies management in Latin America.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1210/er.2018-00262", "doi": "10.1210/er.2018-00262", "title": "Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism", "publicationYear": 2019, "publicationDate": "2019-12-01", "type": "journal-article", "publisher": "The Endocrine Society", "containerTitle": "Endocrine Reviews", "volume": "40", "issue": "6", "page": "1605-1625", "issn": "0163-769X, 1945-7189", "isbn": null, "authors": "Karl-Heinz Storbeck, Lina Schiffer, Elizabeth S Baranowski, Vasileios Chortis, Alessandro Prete, Lise Barnard, Lorna C Gilligan, Angela E Taylor, Jan Idkowiak, Wiebke Arlt, Cedric H L Shackleton", "authorCount": 11, "firstAuthorAffiliation": "Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa", "isReferencedByCount": 130, "referenceCount": 191, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust, Wellcome Trust, Medical Research Council, Medical Research Council, Diabetes UK, Academy of Medical Sciences UK", "funderIds": "10.13039/100010269, 10.13039/100010269, 10.13039/501100000265, 10.13039/501100000265, 10.13039/501100000361", "url": "https://doi.org/10.1210/er.2018-00262", "pdfUrl": "http://academic.oup.com/edrv/advance-article-pdf/doi/10.1210/er.2018-00262/28920623/er.2018-00262.pdf", "abstract": "AbstractSteroid biosynthesis and metabolism are reflected by the serum steroid metabolome and, in even more detail, by the 24-hour urine steroid metabolome, which can provide unique insights into alterations of steroid flow and output indicative of underlying conditions. Mass spectrometry–based steroid metabolome profiling has allowed for the identification of unique multisteroid signatures associated with disorders of steroid biosynthesis and metabolism that can be used for personalized approaches to diagnosis, differential diagnosis, and prognostic prediction. Additionally, steroid metabolome analysis has been used successfully as a discovery tool, for the identification of novel steroidogenic disorders and pathways as well as revealing insights into the pathophysiology of adrenal disease. Increased availability and technological advances in mass spectrometry–based methodologies have refocused attention on steroid metabolome profiling and facilitated the development of high-throughput steroid profiling methods soon to reach clinical practice. Furthermore, steroid metabolomics, the combination of mass spectrometry–based steroid analysis with machine learning–based approaches, has facilitated the development of powerful customized diagnostic approaches. In this review, we provide a comprehensive up-to-date overview of the utility of steroid metabolome analysis for the diagnosis and management of inborn disorders of steroidogenesis and autonomous adrenal steroid excess in the context of adrenal tumors.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1210/endocr/bqaa231", "doi": "10.1210/endocr/bqaa231", "title": "11-Oxygenated Estrogens Are a Novel Class of Human Estrogens but Do not Contribute to the Circulating Estrogen Pool", "publicationYear": 2021, "publicationDate": "2021-03-01", "type": "journal-article", "publisher": "The Endocrine Society", "containerTitle": "Endocrinology", "volume": "162", "issue": "3", "page": null, "issn": "0013-7227, 1945-7170", "isbn": null, "authors": "Lise Barnard, Lina Schiffer, Renate Louw du-Toit, Jennifer A Tamblyn, Shiuan Chen, Donita Africander, Wiebke Arlt, Paul A Foster, Karl-Heinz Storbeck", "authorCount": 9, "firstAuthorAffiliation": "Department of Biochemistry, Stellenbosch University, Matieland, South Africa", "isReferencedByCount": 23, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Academy of Medical Sciences, Wellcome Trust, National Research Foundation, National Institutes of Health, National Institutes of Health, University of Birmingham", "funderIds": "10.13039/501100000691, 10.13039/100010269, 10.13039/501100001321, 10.13039/100000002, 10.13039/100000002, 10.13039/501100000855", "url": "https://doi.org/10.1210/endocr/bqaa231", "pdfUrl": "http://academic.oup.com/endo/advance-article-pdf/doi/10.1210/endocr/bqaa231/35017456/bqaa231.pdf", "abstract": "Abstract Androgens are the obligatory precursors of estrogens. In humans, classic androgen biosynthesis yields testosterone, thought to represent the predominant circulating active androgen both in men and women. However, recent work has shown that 11-ketotestosterone, derived from the newly described 11-oxygenated androgen biosynthesis pathway, makes a substantial contribution to the active androgen pool in women. Considering that classic androgens are the obligatory substrates for estrogen biosynthesis catalyzed by cytochrome P450 aromatase, we hypothesized that 11-oxygenated androgens are aromatizable. Here we use steroid analysis by tandem mass spectrometry to demonstrate that human aromatase generates 11-oxygenated estrogens from 11-oxygenated androgens in 3 different cell-based aromatase expression systems and in human ex vivo placenta explant cultures. We also show that 11-oxygenated estrogens are generated as a byproduct of the aromatization of classic androgens. We show that 11β-hydroxy-17β-estradiol binds and activates estrogen receptors α and β and that 11β-hydroxy-17β-estradiol and the classic androgen pathway-derived active estrogen, 17β-estradiol, are equipotent in stimulating breast cancer cell line proliferation and expression of estrogen-responsive genes. 11-oxygenated estrogens were, however, not detectable in serum from individuals with high aromatase levels (pregnant women) and elevated 11-oxygenated androgen levels (patients with congenital adrenal hyperplasia or adrenocortical carcinoma). Our data show that while 11-oxygenated androgens are aromatizable in vitro and ex vivo, the resulting 11-oxygenated estrogens are not detectable in circulation, suggesting that 11-oxygenated androgens function primarily as androgens in vivo.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1002/ijc.34852", "doi": "10.1002/ijc.34852", "title": "Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta‐analysis", "publicationYear": 2024, "publicationDate": "2024-05-15", "type": "journal-article", "publisher": "Wiley", "containerTitle": "International Journal of Cancer", "volume": "154", "issue": "10", "page": "1745-1759", "issn": "0020-7136, 1097-0215", "isbn": null, "authors": "Maartje Basten, Kuan‐Yu Pan, Lonneke A. van Tuijl, Alexander de Graeff, Joost Dekker, Adriaan W. Hoogendoorn, Femke Lamers, Adelita V. Ranchor, Roel Vermeulen, Lützen Portengen, Adri C. Voogd, Jessica Abell, Philip Awadalla, Aartjan T. F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Philipp Frank, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Martijn Huisman, Anke Huss, Melanie R. Keats, Almar A. L. Kok, Steinar Krokstad, Flora E. van Leeuwen, Annemarie I. Luik, Nolwenn Noisel, Yves Payette, Brenda W. J. H. Penninx, Ina Rissanen, Annelieke M. Roest, Judith G. M. Rosmalen, Rikje Ruiter, Robert A. Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R. Sund, Ellen Sweeney, Emma L. Twait, Alison Teyhan, W. M. Monique Verschuren, Kimberly D. van der Willik, Mirjam I. Geerlings", "authorCount": 47, "firstAuthorAffiliation": "Julius Center for Health Sciences and Primary Care University Medical Center Utrecht and Utrecht University  Utrecht The Netherlands", "isReferencedByCount": 23, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "KWF Kankerbestrijding, Medical Research Council, Wellcome Trust, National Institute on Aging, National Institute for Health and Care Research, ZonMw", "funderIds": "10.13039/501100004622, 10.13039/501100000265, 10.13039/100010269, 10.13039/100000049, 10.13039/501100000272, 10.13039/501100001826", "url": "https://doi.org/10.1002/ijc.34852", "pdfUrl": null, "abstract": "AbstractDepression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two‐stage individual participant data meta‐analyses were performed based on 22 cohorts of the PSYchosocial factors and CAncer (PSY‐CA) study. We examined nine psychosocial factors (depression diagnosis, depression symptoms, anxiety diagnosis, anxiety symptoms, perceived social support, loss events, general distress, neuroticism, relationship status), seven health behaviors/behavior‐related factors (smoking, alcohol use, physical activity, body mass index, sedentary behavior, sleep quality, sleep duration) and seven cancer outcomes (overall cancer, smoking‐related, alcohol‐related, breast, lung, prostate, colorectal). Effects of the psychosocial factor, health behavior and their product term on cancer incidence were estimated using Cox regression. We pooled cohort‐specific estimates using multivariate random‐effects meta‐analyses. Additive and multiplicative interaction/effect modification was examined. This study involved 437,827 participants, 36,961 incident cancer diagnoses, and 4,749,481 person years of follow‐up. Out of 744 combinations of psychosocial factors, health behaviors, and cancer outcomes, we found no evidence of interaction. Effect modification was found for some combinations, but there were no clear patterns for any particular factors or outcomes involved. In this first large study to systematically examine potential interaction and effect modification, we found no evidence for psychosocial factors to interact with or modify health behaviors in relation to cancer incidence. The behavioral risk profile for cancer incidence is similar in people with and without psychosocial stress.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1096/fj.202302131r", "doi": "10.1096/fj.202302131r", "title": "Inhibition of the glucocorticoid‐activating enzyme 11β‐hydroxysteroid dehydrogenase type 1 drives concurrent 11‐oxygenated androgen excess", "publicationYear": 2024, "publicationDate": "2024-04-15", "type": "journal-article", "publisher": "Wiley", "containerTitle": "The FASEB Journal", "volume": "38", "issue": "7", "page": null, "issn": "0892-6638, 1530-6860", "isbn": null, "authors": "Lina Schiffer, Imken Oestlund, Jacky L. Snoep, Lorna C. Gilligan, Angela E. Taylor, Alexandra J. Sinclair, Rishi Singhal, Adrian Freeman, Ramzi Ajjan, Ana Tiganescu, Wiebke Arlt, Karl‐Heinz Storbeck", "authorCount": 12, "firstAuthorAffiliation": "Institute of Metabolism and Systems Research University of Birmingham  Birmingham UK", "isReferencedByCount": 15, "referenceCount": 81, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Research Foundation, National Research Foundation, National Research Foundation, Academy of Medical Sciences, Wellcome Trust, Medical Research Council", "funderIds": "10.13039/501100001321, 10.13039/501100001321, 10.13039/501100001321, 10.13039/501100000691, 10.13039/100010269, 10.13039/501100000265", "url": "https://doi.org/10.1096/fj.202302131r", "pdfUrl": null, "abstract": "Abstract Aldo‐keto reductase 1C3 (AKR1C3) is a key enzyme in the activation of both classic and 11‐oxygenated androgens. In adipose tissue, AKR1C3 is co‐expressed with 11β‐hydroxysteroid dehydrogenase type 1 (HSD11B1), which catalyzes not only the local activation of glucocorticoids but also the inactivation of 11‐oxygenated androgens, and thus has the potential to counteract AKR1C3. Using a combination of in vitro assays and in silico modeling we show that HSD11B1 attenuates the biosynthesis of the potent 11‐oxygenated androgen, 11‐ketotestosterone (11KT), by AKR1C3. Employing ex vivo incubations of human female adipose tissue samples we show that inhibition of HSD11B1 results in the increased peripheral biosynthesis of 11KT. Moreover, circulating 11KT increased 2–3 fold in individuals with type 2 diabetes after receiving the selective oral HSD11B1 inhibitor AZD4017 for 35 days, thus confirming that HSD11B1 inhibition results in systemic increases in 11KT concentrations. Our findings show that HSD11B1 protects against excess 11KT production by adipose tissue, a finding of particular significance when considering the evidence for adverse metabolic effects of androgens in women. Therefore, when targeting glucocorticoid activation by HSD11B1 inhibitor treatment in women, the consequently increased generation of 11KT may offset beneficial effects of decreased glucocorticoid activation.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1093/gbe/evaa079", "doi": "10.1093/gbe/evaa079", "title": "Loss of the Polyketide Synthase StlB Results in Stalk Cell Overproduction in Polysphondylium violaceum", "publicationYear": 2020, "publicationDate": "2020-05-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Genome Biology and Evolution", "volume": "12", "issue": "5", "page": "674-683", "issn": "1759-6653", "isbn": null, "authors": "Takaaki B Narita, Yoshinori Kawabe, Koryu Kin, Richard A Gibbs, Adam Kuspa, Donna M Muzny, Stephen Richards, Joan E Strassmann, Richard Sucgang, Kim C Worley, Pauline Schaap", "authorCount": 11, "firstAuthorAffiliation": "School of Life Sciences, University of Dundee, United Kingdom", "isReferencedByCount": 14, "referenceCount": 37, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "National Science Foundation, National Institutes of Health, Japanese Society for the Promotion of Science, Japanese Society for the Promotion of Science, European Molecular Biology Organisation, Wellcome Trust, European Research Council", "funderIds": "10.13039/100000001, 10.13039/100000002, 10.13039/501100001691, 10.13039/501100001691, 10.13039/100004410, 10.13039/100010269, 10.13039/100010663", "url": "https://doi.org/10.1093/gbe/evaa079", "pdfUrl": "http://academic.oup.com/gbe/advance-article-pdf/doi/10.1093/gbe/evaa079/33198941/evaa079.pdf", "abstract": "Abstract Major phenotypic innovations in social amoeba evolution occurred at the transition between the Polysphondylia and group 4 Dictyostelia, which comprise the model organism Dictyostelium discoideum, such as the formation of a new structure, the basal disk. Basal disk differentiation and robust stalk formation require the morphogen DIF-1, synthesized by the polyketide synthase StlB, the des-methyl-DIF-1 methyltransferase DmtA, and the chlorinase ChlA, which are conserved throughout Dictyostelia. To understand how the basal disk and other innovations evolved in group 4, we sequenced and annotated the Polysphondylium violaceum (Pvio) genome, performed cell type-specific transcriptomics to identify cell-type marker genes, and developed transformation and gene knock-out procedures for Pvio. We used the novel methods to delete the Pvio stlB gene. The Pvio stlB− mutants formed misshapen curly sorogens with thick and irregular stalks. As fruiting body formation continued, the upper stalks became more regular, but structures contained 40% less spores. The stlB− sorogens overexpressed a stalk gene and underexpressed a (pre)spore gene. Normal fruiting body formation and sporulation were restored in Pvio stlB− by including DIF-1 in the supporting agar. These data indicate that, although conserved, stlB and its product(s) acquired both a novel role in the group 4 Dictyostelia and a role opposite to that in its sister group.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.3390/su10103636", "doi": "10.3390/su10103636", "title": "A Comparative Analysis of Global Datasets and Initiatives for Urban Health and Sustainability", "publicationYear": 2018, "publicationDate": "2018-10-11", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Sustainability", "volume": "10", "issue": "10", "page": "3636", "issn": "2071-1050", "isbn": null, "authors": "Jonathon Taylor, Andy Haines, James Milner, Mike Davies, Paul Wilkinson", "authorCount": 5, "firstAuthorAffiliation": "Institute for Environmental Design and Engineering, University College London, Central House, 14 Upper Woburn Place, London WC1H 0NN, UK", "isReferencedByCount": 6, "referenceCount": 83, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.3390/su10103636", "pdfUrl": null, "abstract": "Globally, urban populations are growing rapidly, and in most cases their demands for resources are beyond current limits of sustainability. Cities are therefore critical for achieving national and international sustainability objectives, such as greenhouse gas reduction. Improving sustainability may also provide opportunities for urban population health co-benefits by reducing unhealthy exposures and behaviours. However, there is currently sparse empirical evidence on the degree to which city characteristics are associated with variations in health-related exposures, behaviours and sustainability. This paper examines the feasibility of aggregating empirical data relating to sustainability and health for global cities. An initial scoping review of existing English-language datasets and networks is performed. Resulting datasets are analysed for data types, collection method, and the distribution of contributing cities across climates, population sizes, and wealth. The review indicates datasets are populated using inconsistent methodologies and metrics and have poor overlap of cities between them. Data and organisations tend to be biased towards larger and wealthier cities, and concentrated in Europe and North America. Therefore, despite vast amounts of available data, limitations of reliability, representativeness, and disparate sources mean researchers are faced with significant obstacles when aggregating data to analyse the sustainability and health of globally representative samples of cities.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1128/mbio.00614-19", "doi": "10.1128/mbio.00614-19", "title": "Structure and Properties of a Natural Competence-Associated Pilin Suggest a Unique Pilus Tip-Associated DNA Receptor", "publicationYear": 2019, "publicationDate": "2019-06-25", "type": "journal-article", "publisher": "American Society for Microbiology", "containerTitle": "mBio", "volume": "10", "issue": "3", "page": null, "issn": "2161-2129, 2150-7511", "isbn": null, "authors": "Mohd Zulkifli Salleh, Vijaykumar Karuppiah, Matthew Snee, Angela Thistlethwaite, Colin W. Levy, David Knight, Jeremy P. Derrick", "authorCount": 7, "firstAuthorAffiliation": "Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom", "isReferencedByCount": 30, "referenceCount": 75, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Terengganu State Government Foundation, Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.1128/mbio.00614-19", "pdfUrl": "https://journals.asm.org/doi/pdf/10.1128/mBio.00614-19", "abstract": "Thermus thermophilus is a thermophilic bacterium which is capable of natural transformation, the uptake of external DNA with high efficiency. DNA uptake is thought to be mediated by a competence-associated pilus, which binds the DNA substrate and mediates its transfer across the outer membrane and periplasm. Here, we describe the structural and functional analysis of two pilins which are known to be essential for DNA uptake, ComZ and PilA2. ComZ adopts an unusual structure, incorporating a large β-solenoid domain into the pilin structural framework. We argue on structural grounds that this structure cannot readily be accommodated into the competence pilus fiber unless it is at the tip. We also show that ComZ binds DNA and identify two lysine residues which appear to be important for DNA binding. These results suggest a model in which ComZ and PilA2 form a tip-associated DNA receptor which mediates DNA uptake.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1038/s41598-020-74990-1", "doi": "10.1038/s41598-020-74990-1", "title": "Metampicillin is a cyclic aminal produced by reaction of ampicillin with formaldehyde", "publicationYear": 2020, "publicationDate": "2020-10-21", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Scientific Reports", "volume": "10", "issue": "1", "page": null, "issn": "2045-2322", "isbn": null, "authors": "Raphael Reinbold, Tobias John, Paolo Spingardi, Akane Kawamura, Christopher J. Schofield, Richard J. Hopkinson", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 15, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "Wellcome Trust, Wellcome Trust, Wellcome Trust, Wellcome Trust, Biotechnology and Biological Sciences Research Council, Biotechnology and Biological Sciences Research Council, Biotechnology and Biological Sciences Research Council, Biotechnology and Biological Sciences Research Council, Cancer Research UK, Cancer Research UK, Cancer Research UK, Cancer Research UK, Engineering and Physical Sciences Research Council", "funderIds": "10.13039/100010269, 10.13039/100010269, 10.13039/100010269, 10.13039/100010269, 10.13039/501100000268, 10.13039/501100000268, 10.13039/501100000268, 10.13039/501100000268, 10.13039/501100000289, 10.13039/501100000289, 10.13039/501100000289, 10.13039/501100000289, 10.13039/501100000266", "url": "https://doi.org/10.1038/s41598-020-74990-1", "pdfUrl": "https://www.nature.com/articles/s41598-020-74990-1.pdf", "abstract": "AbstractMetampicillin is a β-lactam antibiotic that is prepared by the reaction of ampicillin with formaldehyde. Although metampicillin has been studied for treatment of infections in animals and humans, its structure has been unclear. We report NMR studies revealing that metampicillin contains a formaldehyde-derived cyclic aminal. NMR time-course experiments with excess formaldehyde in solution show formation of another product with an additional exocyclic hemiaminal group formed by reaction with the cyclic aminal nitrogen. The exocyclic hemiaminal group is readily removed by reaction with the formaldehyde scavenger 1,3-cyclohexanedione, whereas the cyclic aminal methylene exhibits greater stability. The overall results assign the structure of metampicillin as containing a cyclic aminal and further reveal the potential for complexity in the reaction of formaldehyde with biomedicinally relevant molecules.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.15252/emmm.201910865", "doi": "10.15252/emmm.201910865", "title": "Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?", "publicationYear": 2020, "publicationDate": "2020-10-07", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "EMBO Molecular Medicine", "volume": "12", "issue": "10", "page": null, "issn": "1757-4676, 1757-4684", "isbn": null, "authors": "Mark Sweeney, Ben Corden, Stuart A Cook", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 178, "referenceCount": 360, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust, MOH | National Medical Research Council, MOH | National Medical Research Council, UKRI | Medical Research Council, British Heart Foundation, Fondation Leducq", "funderIds": "10.13039/100010269, 10.13039/501100000274, 10.13039/501100001674", "url": "https://doi.org/10.15252/emmm.201910865", "pdfUrl": "https://link.springer.com/content/pdf/10.15252/emmm.201910865.pdf", "abstract": "Abstract Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with preserved ejection fraction (HFpEF). Irrespective of the underlying profibrotic condition (e.g. ageing, diabetes, hypertension), maladaptive cardiac fibrosis is defined by the transformation of resident fibroblasts to matrix‐secreting myofibroblasts. Numerous profibrotic factors have been identified at the molecular level (e.g. TGFβ, IL11, AngII), which activate gene expression programs for myofibroblast activation. A number of existing HF therapies indirectly target fibrotic pathways; however, despite multiple clinical trials in HFpEF, a specific clinically effective antifibrotic therapy remains elusive. Therapeutic inhibition of TGFβ, the master‐regulator of fibrosis, has unfortunately proven toxic and ineffective in clinical trials to date, and new approaches are needed. In this review, we discuss the pathophysiology and clinical implications of interstitial fibrosis in HFpEF. We provide an overview of trials targeting fibrosis in HFpEF to date and discuss the promise of potential new therapeutic approaches and targets in the context of underlying molecular mechanisms.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.3390/membranes10100255", "doi": "10.3390/membranes10100255", "title": "Electrophysiology Measurements of Metal Transport by MntH2 from Enterococcus faecalis", "publicationYear": 2020, "publicationDate": "2020-09-24", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Membranes", "volume": "10", "issue": "10", "page": "255", "issn": "2077-0375", "isbn": null, "authors": "Matthias Gantner, Theodoros Laftsoglou, Honglin Rong, Vincent L. G. Postis, Lars J. C. Jeuken", "authorCount": 5, "firstAuthorAffiliation": "School of Biomedical Sciences and the Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK", "isReferencedByCount": 0, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust, European Research Council", "funderIds": "10.13039/100010269, 10.13039/501100000781", "url": "https://doi.org/10.3390/membranes10100255", "pdfUrl": null, "abstract": "Transition metals are essential trace elements and their high-affinity uptake is required for many organisms. Metal transporters are often characterised using metal-sensitive fluorescent dyes, limiting the metals and experimental conditions that can be studied. Here, we have tested whether metal transport by Enterococcus faecalis MntH2 can be measured with an electrophysiology method that is based on the solid-supported membrane technology. E. faecalis MntH2 belongs to the Natural Resistance-Associated Macrophage Protein (Nramp) family of proton-coupled transporters, which transport divalent transition metals and do not transport the earth metals. Electrophysiology confirms transport of Mn(II), Co(II), Zn(II) and Cd(II) by MntH2. However, no uptake responses for Cu(II), Fe(II) and Ni(II) were observed, while the presence of these metals abolishes the uptake signals for Mn(II). Fluorescence assays confirm that Ni(II) is transported. The data are discussed with respect to properties and structures of Nramp-type family members and the ability of electrophysiology to measure charge transport and not directly substrate transport.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.3390/biology10101050", "doi": "10.3390/biology10101050", "title": "Mitochondrial Translation Occurs Preferentially in the Peri-Nuclear Mitochondrial Network of Cultured Human Cells", "publicationYear": 2021, "publicationDate": "2021-10-15", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Biology", "volume": "10", "issue": "10", "page": "1050", "issn": "2079-7737", "isbn": null, "authors": "Christin A. Albus, Rolando Berlinguer-Palmini, Caroline Hewison, Fiona McFarlane, Elisabeta-Ana Savu, Robert N. Lightowlers, Zofia M. Chrzanowska-Lightowlers, Matthew Zorkau", "authorCount": 8, "firstAuthorAffiliation": "Wellcome Centre for Mitochondrial Research, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK", "isReferencedByCount": 2, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.3390/biology10101050", "pdfUrl": null, "abstract": "Human mitochondria are highly dynamic organelles, fusing and budding to maintain reticular networks throughout many cell types. Although extending to the extremities of the cell, the majority of the network is concentrated around the nucleus in most of the commonly cultured cell lines. This organelle harbours its own genome, mtDNA, with a different gene content to the nucleus, but the expression of which is critical for maintaining oxidative phosphorylation. Recent advances in click chemistry have allowed us to visualise sites of mitochondrial protein synthesis in intact cultured cells. We show that the majority of translation occurs in the peri-nuclear region of the network. Further analysis reveals that whilst there is a slight peri-nuclear enrichment in the levels of mitoribosomal protein and mitochondrial rRNA, it is not sufficient to explain this substantial heterogeneity in the distribution of translation. Finally, we also show that in contrast, a mitochondrial mRNA does not show such a distinct gradient in distribution. These data suggest that the relative lack of translation in the peripheral mitochondrial network is not due to an absence of mitoribosomes or an insufficient supply of the mt-mRNA transcripts.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1099/mgen.0.001307", "doi": "10.1099/mgen.0.001307", "title": "Surveillance of travel-associated isolates elucidates the diversity of non-pandemic Vibrio cholerae", "publicationYear": 2024, "publicationDate": "2024-10-16", "type": "journal-article", "publisher": "Microbiology Society", "containerTitle": "Microbial Genomics", "volume": "10", "issue": "10", "page": null, "issn": "2057-5858", "isbn": null, "authors": "Lia Bote, Alyce Taylor-Brown, Mailis Maes, Danielle J. Ingle, Mary Valcanis, Benjamin P. Howden, Nicholas R. Thomson", "authorCount": 7, "firstAuthorAffiliation": "Wellcome Sanger Institute, Hinxton, UK", "isReferencedByCount": 5, "referenceCount": 75, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust, Wellcome Trust, Wellcome Trust, Wellcome Trust", "funderIds": "10.13039/100010269, 10.13039/100010269, 10.13039/100010269, 10.13039/100010269", "url": "https://doi.org/10.1099/mgen.0.001307", "pdfUrl": null, "abstract": "Vibrio cholerae is a Gram-negative bacterium found in aquatic environments and is the aetiological agent of cholera, characterized by acute watery diarrhoea and severe dehydration. Cholera presents a significant global health burden of an estimated 1.3–5 million annual cases, with the current pandemic caused by a toxigenic lineage of the O1 El Tor biotype called seventh pandemic El Tor (7PET) that is still ongoing. Whilst it is known that non-7PET lineages can cause sporadic disease, little is known about the transmission of these non-epidemic lineages. Thirty-four V. cholerae isolates were obtained from travellers returning from Indonesia to Australia between 2005 and 2017. These were whole genome sequenced, placed into a global phylogenetic context with 883 isolates, and screened for known genes associated with antimicrobial resistance and virulence. This analysis revealed that 30 isolates fell within non-7PET lineages and four within the 7PET lineage. Both 7PET and non-7PET isolates carried genes for resistance to antibiotics that are commonly used in cholera treatment such as tetracyclines and fluoroquinolones. Diverse virulence factors were also present in non-7PET isolates, with two isolates notably carrying toxin-coregulated pilus genes, which are primarily responsible for intestinal colonization in 7PET V. cholerae. This study demonstrates the role of travel in long-range carriage of epidemic and non-epidemic lineages of V. cholerae, and how sentinel travel surveillance can enrich our knowledge of V. cholerae diversity, reveal new biology about the spread of diverse lineages with differing disease potential and illuminate disease presence in endemic regions with limited surveillance data.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1093/ofid/ofad488", "doi": "10.1093/ofid/ofad488", "title": "The Natural History of Antibiotic-Treated Lower Limb Cellulitis: Analysis of Data Extracted From a Multicenter Clinical Trial", "publicationYear": 2023, "publicationDate": "2023-09-30", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Open Forum Infectious Diseases", "volume": "10", "issue": "10", "page": null, "issn": "2328-8957", "isbn": null, "authors": "O Martin Williams, Fergus Hamilton, Richard Brindle", "authorCount": 3, "firstAuthorAffiliation": "UK Health Security Agency Microbiology Laboratory Services Bristol, Bristol Royal Infirmary , Bristol , UK", "isReferencedByCount": 6, "referenceCount": 35, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "National Institute for Health Research, Wellcome Trust", "funderIds": "10.13039/501100000272, 10.13039/100010269", "url": "https://doi.org/10.1093/ofid/ofad488", "pdfUrl": "https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad488/51801241/ofad488.pdf", "abstract": "Abstract Background Although cellulitis is a relatively common skin infection, there remains uncertainty about management, particularly the length and route of antimicrobials required. Further information on the symptomatology and biomarker changes associated with cellulitis over time would guide clinicians and patients as to the expected natural history. Methods We extracted data from a randomized clinical trial (NCT01876628) of clindamycin as adjunctive therapy in cellulitis to illustrate the evolution of local parameters (pain, swelling, local erythema, and warmth) and the resolution of biomarkers over time. Results Data from 247 individuals with mild to moderate unilateral lower limb cellulitis, who attended at least 1 face-to-face interview following recruitment, were used to examine response dynamics. Although there was a local improvement in swelling, warmth, erythema, and pain by day 5 compared with baseline, some individuals still had evidence of local inflammation at 10 days. Most biomarkers demonstrated a return to normal by day 3, although the initial fall in albumin only returned to baseline by day 10. Conclusions Although there was initial resolution, a significant number of individuals still had local symptoms persisting to day 10 and beyond. Clinicians can use these data to reassure themselves and their patients that ongoing local symptoms and signs after completion of antibiotic treatment do not indicate treatment failure or warrant extension of the initial antibiotic treatment or a change in antibiotic class or mode of administration.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.3390/bs10100161", "doi": "10.3390/bs10100161", "title": "Neuromodulatory Control and Language Recovery in Bilingual Aphasia: An Active Inference Approach", "publicationYear": 2020, "publicationDate": "2020-10-21", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Behavioral Sciences", "volume": "10", "issue": "10", "page": "161", "issn": "2076-328X", "isbn": null, "authors": "Noor Sajid, Karl Friston, Justyna Ekert, Cathy Price, David Green", "authorCount": 5, "firstAuthorAffiliation": "Wellcome Centre for Human Neuroimaging, University College London, 12 Queen Square, London WC1N 3AR, UK", "isReferencedByCount": 13, "referenceCount": 56, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Medical Research Council, Wellcome Trust", "funderIds": "10.13039/501100000265, 10.13039/100010269", "url": "https://doi.org/10.3390/bs10100161", "pdfUrl": null, "abstract": "Understanding the aetiology of the diverse recovery patterns in bilingual aphasia is a theoretical challenge with implications for treatment. Loss of control over intact language networks provides a parsimonious starting point that can be tested using in-silico lesions. We simulated a complex recovery pattern (alternate antagonism and paradoxical translation) to test the hypothesis—from an established hierarchical control model—that loss of control was mediated by constraints on neuromodulatory resources. We used active (Bayesian) inference to simulate a selective loss of sensory precision; i.e., confidence in the causes of sensations. This in-silico lesion altered the precision of beliefs about task relevant states, including appropriate actions, and reproduced exactly the recovery pattern of interest. As sensory precision has been linked to acetylcholine release, these simulations endorse the conjecture that loss of neuromodulatory control can explain this atypical recovery pattern. We discuss the relevance of this finding for other recovery patterns.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1002/msb.20145228", "doi": "10.1002/msb.20145228", "title": "Non‐enzymatic glycolysis and pentose phosphate pathway‐like reactions in a plausible Archean ocean", "publicationYear": 2014, "publicationDate": "2014-04-01", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Molecular Systems Biology", "volume": "10", "issue": "4", "page": null, "issn": "1744-4292", "isbn": null, "authors": "Markus A Keller, Alexandra V Turchyn, Markus Ralser", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 225, "referenceCount": 61, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Isaac Newton Trust, Wellcome Trust, Royal Society, ERC, ERC", "funderIds": "10.13039/501100004815, 10.13039/100010269, 10.13039/501100000288", "url": "https://doi.org/10.1002/msb.20145228", "pdfUrl": "https://link.springer.com/content/pdf/10.1002/msb.20145228.pdf", "abstract": "Abstract The reaction sequences of central metabolism, glycolysis and the pentose phosphate pathway provide essential precursors for nucleic acids, amino acids and lipids. However, their evolutionary origins are not yet understood. Here, we provide evidence that their structure could have been fundamentally shaped by the general chemical environments in earth's earliest oceans. We reconstructed potential scenarios for oceans of the prebiotic Archean based on the composition of early sediments. We report that the resultant reaction milieu catalyses the interconversion of metabolites that in modern organisms constitute glycolysis and the pentose phosphate pathway. The 29 observed reactions include the formation and/or interconversion of glucose, pyruvate, the nucleic acid precursor ribose‐5‐phosphate and the amino acid precursor erythrose‐4‐phosphate, antedating reactions sequences similar to that used by the metabolic pathways. Moreover, the Archean ocean mimetic increased the stability of the phosphorylated intermediates and accelerated the rate of intermediate reactions and pyruvate production. The catalytic capacity of the reconstructed ocean milieu was attributable to its metal content. The reactions were particularly sensitive to ferrous iron Fe(II), which is understood to have had high concentrations in the Archean oceans. These observations reveal that reaction sequences that constitute central carbon metabolism could have been constrained by the iron‐rich oceanic environment of the early Archean. The origin of metabolism could thus date back to the prebiotic world.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1098/rsos.230405", "doi": "10.1098/rsos.230405", "title": "Multiscale mobility patterns and the restriction of human movement", "publicationYear": 2023, "publicationDate": "2023-10", "type": "journal-article", "publisher": "The Royal Society", "containerTitle": "Royal Society Open Science", "volume": "10", "issue": "10", "page": null, "issn": "2054-5703", "isbn": null, "authors": "Juni Schindler, Jonathan Clarke, Mauricio Barahona", "authorCount": 3, "firstAuthorAffiliation": "Imperial College London", "isReferencedByCount": 10, "referenceCount": 60, "isOpenAccess": true, "licenseUrl": "https://royalsociety.org/journals/ethics-policies/data-sharing-mining/", "funderNames": "Engineering and Physical Sciences Research Council, Engineering and Physical Sciences Research Council, Wellcome Trust", "funderIds": "10.13039/501100000266, 10.13039/501100000266, 10.13039/100010269", "url": "https://doi.org/10.1098/rsos.230405", "pdfUrl": "https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.230405", "abstract": "From the perspective of human mobility, the COVID-19 pandemic constituted a natural experiment of enormous reach in space and time. Here, we analyse the inherent multiple scales of human mobility using Facebook Movement maps collected before and during the first UK lockdown. Firstly, we obtain the pre-lockdown UK mobility graph and employ multiscale community detection to extract, in an unsupervised manner, a set of robust partitions into flow communities at different levels of coarseness. The partitions so obtained capture intrinsic mobility scales with better coverage than nomenclature of territorial units for statistics (NUTS) regions, which suffer from mismatches between human mobility and administrative divisions. Furthermore, the flow communities in the fine-scale partition not only match well the UK travel to work areas but also capture mobility patterns beyond commuting to work. We also examine the evolution of mobility under lockdown and show that mobility first reverted towards fine-scale flow communities already found in the pre-lockdown data, and then expanded back towards coarser flow communities as restrictions were lifted. The improved coverage induced by lockdown is well captured by a linear decay shock model, which allows us to quantify regional differences in both the strength of the effect and the recovery time from the lockdown shock.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1136/bmjopen-2020-040321", "doi": "10.1136/bmjopen-2020-040321", "title": "Triaging of respiratory protective equipment on the assumed risk of SARS-CoV-2 aerosol exposure in patient-facing healthcare workers delivering secondary care: a rapid review", "publicationYear": 2020, "publicationDate": "2020-10", "type": "journal-article", "publisher": "BMJ", "containerTitle": "BMJ Open", "volume": "10", "issue": "10", "page": "e040321", "issn": "2044-6055, 2044-6055", "isbn": null, "authors": "Prashanth Ramaraj, Jonathan Super, Ruben Doyle, Christopher Aylwin, Shehan Hettiaratchy", "authorCount": 5, "firstAuthorAffiliation": "Major Trauma Centre, Imperial College Healthcare NHS Trust, London, UK", "isReferencedByCount": 5, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc/4.0/", "funderNames": "Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.1136/bmjopen-2020-040321", "pdfUrl": null, "abstract": "Objectives In patient-facing healthcare workers delivering secondary care, what is the evidence behind UK Government personal protective equipment (PPE) guidance on surgical masks versus respirators for SARS-CoV-2 protection? Design Two independent reviewers performed a rapid review. Appraisal was performed using Critical Appraisal Skills Programme checklists and Grading of Recommendations, Assessment, Development and Evaluations methodology. Results were synthesised by comparison of findings and appraisals. Data sources MEDLINE, Google Scholar, UK Government COVID-19 website and grey literature. Eligibility criteria Studies published on any date containing primary data comparing surgical facemasks and respirators specific to SARS-CoV-2, and studies underpinning UK Government PPE guidance, were included. Results Of 30 identified, only 3 laboratory studies of 14 different respirators and 12 surgical facemasks were found. In all three, respirators were significantly more effective than facemasks when comparing protection factors, reduction factors, filter penetrations, total inspiratory leakages at differing particle sizes, mean inspiratory flows and breathing rates. Tests included live viruses and inert particles on dummies and humans. In the six clinical studies (6502 participants) included the only statistically significant result found continuous use of respirators more effective in clinical respiratory illness compared with targeted use or surgical facemasks. There was no consistent definition of ‘exposure’ to determine the efficacy of respiratory protective equipment (RPE). It is difficult to define ‘safe’. Conclusions There is a paucity of evidence on the comparison of facemasks and respirators specific to SARS-CoV-2, and poor-quality evidence in other contexts. The use of surrogates results in extrapolation of non-SARS-CoV-2 specific data to guide UK Government PPE guidance. The appropriateness of this is unknown given the uncertainty over the transmission of SARS-CoV-2. This means that the evidence base for UK Government PPE guidelines is not based on SARS-CoV-2 and requires generalisation from low-quality evidence of other pathogens/particles. There is a paucity of high-quality evidence regarding the efficacy of RPE specific to SARS-CoV-2. UK Government PPE guidelines are underpinned by the assumption of droplet transmission of SARS-CoV-2. These factors suggest that the triaging of filtering face piece class 3 respirators might increase the risk of COVID-19 faced by some.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1098/rsif.2016.0133", "doi": "10.1098/rsif.2016.0133", "title": "Distinct properties of semiquinone species detected at the ubiquinol oxidation Qo site of cytochrome <i>bc</i> 1 and their mechanistic implications", "publicationYear": 2016, "publicationDate": "2016-05-31", "type": "journal-article", "publisher": "The Royal Society", "containerTitle": "Journal of The Royal Society Interface", "volume": "13", "issue": "118", "page": null, "issn": "1742-5689, 1742-5662", "isbn": null, "authors": "Rafał Pietras, Marcin Sarewicz, Artur Osyczka", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 27, "referenceCount": 69, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust, Wellcome Trust", "funderIds": "10.13039/100010269, 10.13039/100004440", "url": "https://doi.org/10.1098/rsif.2016.0133", "pdfUrl": "https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2016.0133", "abstract": "Abstract The two-electron ubiquinol oxidation or ubiquinone reduction typically involves semiquinone (SQ) intermediates. Natural engineering of ubiquinone binding sites of bioenergetic enzymes secures that SQ is sufficiently stabilized, so that it does not leave the site to membranous environment before full oxidation/reduction is completed. The ubiquinol oxidation Qo site of cytochrome bc1 (mitochondrial complex III, cytochrome b6f in plants) has been considered an exception with catalytic reactions assumed to involve highly unstable SQ or not to involve any SQ intermediate. This view seemed consistent with long-standing difficulty in detecting any reaction intermediates at the Qo site. New perspective on this issue is now offered by recent, independent reports on detection of SQ in this site. Each of the described SQs seems to have different spectroscopic properties leaving space for various interpretations and mechanistic considerations. Here, we comparatively reflect on those properties and their consequences on the SQ stabilization, the involvement of SQ in catalytic reactions, including proton transfers, and the reactivity of SQ with oxygen associated with superoxide generation activity of the Qo site.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1186/s12936-022-04301-8", "doi": "10.1186/s12936-022-04301-8", "title": "Severe malaria", "publicationYear": 2022, "publicationDate": "2022-10-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Malaria Journal", "volume": "21", "issue": "1", "page": null, "issn": "1475-2875", "isbn": null, "authors": "Nicholas J. White", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 191, "referenceCount": 138, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": "Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.1186/s12936-022-04301-8", "pdfUrl": "https://link.springer.com/content/pdf/10.1186/s12936-022-04301-8.pdf", "abstract": "AbstractSevere malaria is a medical emergency. It is a major cause of preventable childhood death in tropical countries. Severe malaria justifies considerable global investment in malaria control and elimination yet, increasingly, international agencies, funders and policy makers are unfamiliar with it, and so it is overlooked. In sub-Saharan Africa, severe malaria is overdiagnosed in clinical practice. Approximately one third of children diagnosed with severe malaria have another condition, usually sepsis, as the cause of their severe illness. But these children have a high mortality, contributing substantially to the number of deaths attributed to ‘severe malaria’. Simple well-established tests, such as examination of the thin blood smear and the full blood count, improve the specificity of diagnosis and provide prognostic information in severe malaria. They should be performed more widely. Early administration of artesunate and broad-spectrum antibiotics to all children with suspected severe malaria would reduce global malaria mortality.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1093/ofid/ofaa385", "doi": "10.1093/ofid/ofaa385", "title": "Molecular Epidemiology of Human Rhinovirus From 1-Year Surveillance Within a School Setting in Rural Coastal Kenya", "publicationYear": 2020, "publicationDate": "2020-10-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Open Forum Infectious Diseases", "volume": "7", "issue": "10", "page": null, "issn": "2328-8957", "isbn": null, "authors": "Martha M Luka, Everlyn Kamau, Irene Adema, Patrick K Munywoki, Grieven P Otieno, Elijah Gicheru, Alex Gichuki, Nelson Kibinge, Charles N Agoti, D James Nokes", "authorCount": 10, "firstAuthorAffiliation": "Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research – Coast, Kilifi, Kenya", "isReferencedByCount": 16, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.1093/ofid/ofaa385", "pdfUrl": "http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaa385/33687378/ofaa385.pdf", "abstract": "Abstract Background Human rhinovirus (HRV) is the most common cause of the common cold but may also lead to more severe respiratory illness in vulnerable populations. The epidemiology and genetic diversity of HRV within a school setting have not been previously described. The objective of this study was to characterize HRV molecular epidemiology in a primary school in a rural location of Kenya. Methods Between May 2017 and April 2018, over 3 school terms, we collected 1859 nasopharyngeal swabs (NPS) from pupils and teachers with symptoms of acute respiratory infection in a public primary school in Kilifi County, coastal Kenya. The samples were tested for HRV using real-time reverse transcription polymerase chain reaction. HRV-positive samples were sequenced in the VP4/VP2 coding region for species and genotype classification. Results A total of 307 NPS (16.4%) from 164 individuals were HRV positive, and 253 (82.4%) were successfully sequenced. The proportion of HRV in the lower primary classes was higher (19.8%) than upper primary classes (12.2%; P &amp;lt; .001). HRV-A was the most common species (134/253; 53.0%), followed by HRV-C (73/253; 28.9%) and HRV-B (46/253; 18.2%). Phylogenetic analysis identified 47 HRV genotypes. The most common genotypes were A2 and B70. Numerous (up to 22 in 1 school term) genotypes circulated simultaneously, there was no individual re-infection with the same genotype, and no genotype was detected in all 3 school terms. Conclusions HRV was frequently detected among school-going children with mild acute respiratory illness symptoms, particularly in the younger age groups (&amp;lt;5-year-olds). Multiple HRV introductions were observed that were characterized by considerable genotype diversity.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1136/bmjgh-2025-019236", "doi": "10.1136/bmjgh-2025-019236", "title": "Stakeholder analysis for ‘One Health’ approach to tackle antimicrobial resistance", "publicationYear": 2025, "publicationDate": "2025-10", "type": "journal-article", "publisher": "BMJ", "containerTitle": "BMJ Global Health", "volume": "10", "issue": "10", "page": "e019236", "issn": "2059-7908", "isbn": null, "authors": "Sanjib Adhikari, Komal Raj Rijal, Daniel M Parker, Prakash Ghimire, Phaik Yeong Cheah, Bipin Adhikari", "authorCount": 6, "firstAuthorAffiliation": "Central Department of Microbiology, Tribhuvan University, Kirtipur, Nepal", "isReferencedByCount": 7, "referenceCount": 53, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Global Health Bioethics Network (GHBN), UK, Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.1136/bmjgh-2025-019236", "pdfUrl": null, "abstract": "Antimicrobial resistance (AMR) and interventions to mitigate it are multisectoral, exhibiting super-wicked features that require intersectoral collaboration and synergy. Although AMR and mitigation strategies are pressing issues, their solutions are complex, ethically challenging, multilayered and often conflict at various levels and among diverse stakeholders. The main objective of this study was to identify the values and potential contributions of stakeholder analysis related to AMR and potential interventions from a case study that is being undertaken in Nepal using a ‘One Health’ approach. A total of 33 representatives from human, animal, agricultural and environmental sectors attended a stakeholder meeting in Kathmandu to discuss AMR, its ethical and practical challenges, opportunities and potential interventions. Using a five-pillar framework for stakeholder analysis, we demonstrate its relevance for addressing AMR and propose practical considerations for implementing effective interventions in Nepal. Beyond the practical discussions on AMR and its interventions at the policy, implementation and practice levels, this study underscores the critical value of its methodological reflections for informing ongoing interventions both within Nepal and in similar contexts globally.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.3390/cells10020339", "doi": "10.3390/cells10020339", "title": "Epithelial Cells and Inflammation in Pulmonary Wound Repair", "publicationYear": 2021, "publicationDate": "2021-02-05", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Cells", "volume": "10", "issue": "2", "page": "339", "issn": "2073-4409", "isbn": null, "authors": "Amanda Croasdell Lucchini, Naomi N. Gachanja, Adriano G. Rossi, David A. Dorward, Christopher D. Lucas", "authorCount": 5, "firstAuthorAffiliation": "University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh Bioquarter, Edinburgh EH16 4TJ, UK", "isReferencedByCount": 70, "referenceCount": 142, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust, Wellcome Trust-University of Edinburgh Institutional Strategic Support Fund, Pathological Society Award", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.3390/cells10020339", "pdfUrl": null, "abstract": "Respiratory diseases are frequently characterised by epithelial injury, airway inflammation, defective tissue repair, and airway remodelling. This may occur in a subacute or chronic context, such as asthma and chronic obstructive pulmonary disease, or occur acutely as in pathogen challenge and acute respiratory distress syndrome (ARDS). Despite the frequent challenge of lung homeostasis, not all pulmonary insults lead to disease. Traditionally thought of as a quiescent organ, emerging evidence highlights that the lung has significant capacity to respond to injury by repairing and replacing damaged cells. This occurs with the appropriate and timely resolution of inflammation and concurrent initiation of tissue repair programmes. Airway epithelial cells are key effectors in lung homeostasis and host defence; continual exposure to pathogens, toxins, and particulate matter challenge homeostasis, requiring robust defence and repair mechanisms. As such, the epithelium is critically involved in the return to homeostasis, orchestrating the resolution of inflammation and initiating tissue repair. This review examines the pivotal role of pulmonary airway epithelial cells in initiating and moderating tissue repair and restitution. We discuss emerging evidence of the interactions between airway epithelial cells and candidate stem or progenitor cells to initiate tissue repair as well as with cells of the innate and adaptive immune systems in driving successful tissue regeneration. Understanding the mechanisms of intercellular communication is rapidly increasing, and a major focus of this review includes the various mediators involved, including growth factors, extracellular vesicles, soluble lipid mediators, cytokines, and chemokines. Understanding these areas will ultimately identify potential cells, mediators, and interactions for therapeutic targeting.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1098/rsfs.2019.0098", "doi": "10.1098/rsfs.2019.0098", "title": "Sleep, circadian rhythms and health", "publicationYear": 2020, "publicationDate": "2020-06-06", "type": "journal-article", "publisher": "The Royal Society", "containerTitle": "Interface Focus", "volume": "10", "issue": "3", "page": null, "issn": "2042-8898, 2042-8901", "isbn": null, "authors": "Russell G. Foster", "authorCount": 1, "firstAuthorAffiliation": "South Parks Road, Oxford OX1 3RE, UK", "isReferencedByCount": 250, "referenceCount": 195, "isOpenAccess": true, "licenseUrl": "http://royalsocietypublishing.org/licence", "funderNames": "Wellcome Trust, Wellcome Trust", "funderIds": "10.13039/100010269, 10.13039/100010269", "url": "https://doi.org/10.1098/rsfs.2019.0098", "pdfUrl": "https://royalsocietypublishing.org/doi/pdf/10.1098/rsfs.2019.0098", "abstract": "Abstract At the core of human thought, for the majority of individuals in the developed nations at least, there is the tacit assumption that as a species we are unfettered by the demands imposed by our biology and that we can do what we want, at whatever time we choose, whereas in reality every aspect of our physiology and behaviour is constrained by a 24 h beat arising from deep within our evolution. Our daily circadian rhythms and sleep/wake cycle allow us to function optimally in a dynamic world, adjusting our biology to the demands imposed by the day/night cycle. The themes developed in this review focus upon the growing realization that we ignore the circadian and sleep systems at our peril, and this paper considers the mechanisms that generate and regulate circadian and sleep systems; what happens mechanistically when these systems collapse as a result of societal pressures and disease; how sleep disruption and stress are linked; why sleep disruption and mental illness invariably occur together; and how individuals and employers can attempt to mitigate some of the problems associated with working against our internal temporal biology. While some of the health costs of sleep disruption can be reduced, in the short-term at least, there will always be significant negative consequences associated with shift work and sleep loss. With this in mind, society needs to address this issue and decide when the consequences of sleep disruption are justified in the workplace.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1242/jcs.230714", "doi": "10.1242/jcs.230714", "title": "Anterior-enriched filopodia create the appearance of asymmetric membrane microdomains in polarizing <i>C. elegans</i> zygotes", "publicationYear": 2019, "publicationDate": "2019-07-15", "type": "journal-article", "publisher": "The Company of Biologists", "containerTitle": "Journal of Cell Science", "volume": "132", "issue": "14", "page": null, "issn": "1477-9137, 0021-9533", "isbn": null, "authors": "Nisha Hirani, Rukshala Illukkumbura, Tom Bland, Grégoire Mathonnet, Delphine Suhner, Anne-Cecile Reymann, Nathan W. Goehring", "authorCount": 7, "firstAuthorAffiliation": "The Francis Crick Institute 1 , 1 Midland Road, London NW1 1AT , UK", "isReferencedByCount": 23, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": "Francis Crick Institute, Cancer Research UK, Medical Research Council, Wellcome Trust, H2020 Marie Skłodowska-Curie Actions, Agence Nationale de la Recherche, LabEx, European Cooperation in Science and Technology, European Molecular Biology Organization", "funderIds": "10.13039/100010438, 10.13039/501100000289, 10.13039/501100000265, 10.13039/100010269, 10.13039/100010665, 10.13039/501100001665, 10.13039/501100004100, 10.13039/501100000921, 10.13039/100004410", "url": "https://doi.org/10.1242/jcs.230714", "pdfUrl": "https://journals.biologists.com/jcs/article-pdf/doi/10.1242/jcs.230714/3506145/jcs230714.pdf", "abstract": "ABSTRACT The association of molecules within membrane microdomains is critical for the intracellular organization of cells. During polarization of the C. elegans zygote, both polarity proteins and actomyosin regulators associate within dynamic membrane-associated foci. Recently, a novel class of asymmetric membrane-associated structures was described that appeared to be enriched in phosphatidylinositol 4,5-bisphosphate (PIP2), suggesting that PIP2 domains could constitute signaling hubs to promote cell polarization and actin nucleation. Here, we probe the nature of these domains using a variety of membrane- and actin cortex-associated probes. These data demonstrate that these domains are filopodia, which are stimulated transiently during polarity establishment and accumulate in the zygote anterior. The resulting membrane protrusions create local membrane topology that quantitatively accounts for observed local increases in the fluorescence signal of membrane-associated molecules, suggesting molecules are not selectively enriched in these domains relative to bulk membrane and that the PIP2 pool as revealed by PHPLCδ1 simply reflects plasma membrane localization. Given the ubiquity of 3D membrane structures in cells, including filopodia, microvilli and membrane folds, similar caveats are likely to apply to analysis of membrane-associated molecules in a broad range of systems.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1192/bjo.2024.10", "doi": "10.1192/bjo.2024.10", "title": "Immune response to vaccination in people with psychotic disorders relative to healthy controls: prospective study of SARS-CoV-2 vaccination", "publicationYear": 2024, "publicationDate": "2024-03", "type": "journal-article", "publisher": "Royal College of Psychiatrists", "containerTitle": "BJPsych Open", "volume": "10", "issue": "2", "page": null, "issn": "2056-4724", "isbn": null, "authors": "Oisín O'Brien, Atheeshaan Arumuham, Yuya Mizuno, Luke Baxter, Maria Lobo, Sita Parmar, Stephen Jolles, Oliver D. Howes", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 12, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Medical Research Council, Maudsley Charity, Wellcome Trust", "funderIds": "10.13039/501100000265, 10.13039/100012176, 10.13039/100010269", "url": "https://doi.org/10.1192/bjo.2024.10", "pdfUrl": null, "abstract": "Summary This prospective study examines the immune response to SARS-CoV-2 vaccination in patients with psychotic disorders compared with healthy volunteers. Participants were recruited naturalistically as part of the UK's COVID-19 vaccination programme. Prior to receiving their first COVID-19 vaccine, blood samples were provided by participants to examine anti-SARS-CoV-2 immunoglobulins (IgG) at baseline, followed by a repeat assay 1 month after receiving their first vaccine to assess vaccine response. The increase of IgG levels from baseline to 1 month post-vaccination was significantly lower in patients compared with controls, supporting evidence of impaired vaccine response in people with psychotic disorders. When excluding patients treated with clozapine from the analysis, this difference was no longer significant, suggesting that effects may be particularly marked in people taking clozapine.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1242/dmm.050238", "doi": "10.1242/dmm.050238", "title": "Increase in brain glycogen levels ameliorates Huntington's disease phenotype and rescues neurodegeneration in <i>Drosophila</i>", "publicationYear": 2023, "publicationDate": "2023-10-01", "type": "journal-article", "publisher": "The Company of Biologists", "containerTitle": "Disease Models &amp; Mechanisms", "volume": "16", "issue": "10", "page": null, "issn": "1754-8403, 1754-8411", "isbn": null, "authors": "Akanksha Onkar, Deepashree Sheshadri, Anupama Rai, Arjit Kant Gupta, Nitin Gupta, Subramaniam Ganesh", "authorCount": 6, "firstAuthorAffiliation": "Indian Institute of Technology 1 Department of Biological Sciences and Bioengineering , (IIT), Kanpur 208016 , India", "isReferencedByCount": 12, "referenceCount": 81, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": "University Grants Commission, Wellcome Trust, Indian Institute of Technology", "funderIds": "10.13039/100010269, 10.13039/501100007488", "url": "https://doi.org/10.1242/dmm.050238", "pdfUrl": "https://journals.biologists.com/dmm/article-pdf/doi/10.1242/dmm.050238/3141130/dmm050238.pdf", "abstract": "ABSTRACT Under normal physiological conditions, the mammalian brain contains very little glycogen, most of which is stored in astrocytes. However, the aging brain and the subareas of the brain in patients with neurodegenerative disorders tend to accumulate glycogen, the cause and significance of which remain largely unexplored. Using cellular models, we have recently demonstrated a neuroprotective role for neuronal glycogen and glycogen synthase in the context of Huntington's disease. To gain insight into the role of brain glycogen in regulating proteotoxicity, we utilized a Drosophila model of Huntington's disease, in which glycogen synthase is either knocked down or expressed ectopically. Enhancing glycogen synthesis in the brains of flies with Huntington's disease decreased mutant Huntingtin aggregation and reduced oxidative stress by activating auto-lysosomal functions. Further, overexpression of glycogen synthase in the brain rescues photoreceptor degeneration, improves locomotor deficits and increases fitness traits in this Huntington's disease model. We, thus, provide in vivo evidence for the neuroprotective functions of glycogen synthase and glycogen in neurodegenerative conditions, and their role in the neuronal autophagy process.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1073/pnas.1504162112", "doi": "10.1073/pnas.1504162112", "title": "Age-related changes in working memory and the ability to ignore distraction", "publicationYear": 2015, "publicationDate": "2015-05-19", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "112", "issue": "20", "page": "6515-6518", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Fiona McNab, Peter Zeidman, Robb B. Rutledge, Peter Smittenaar, Harriet R. Brown, Rick A. Adams, Raymond J. Dolan", "authorCount": 7, "firstAuthorAffiliation": "School of Psychology, University of Birmingham, Birmingham, B15 2TT, United Kingdom;", "isReferencedByCount": 99, "referenceCount": 22, "isOpenAccess": true, "licenseUrl": "http://www.pnas.org/site/misc/userlicense.xhtml", "funderNames": "The Wellcome Trust, The Wellcome Trust, The Wellcome Trust, The Brain Research Trust, The Wellcome Trust, The Wellcome Trust", "funderIds": "10.13039/100010269, 10.13039/100010269, 10.13039/100010269, 10.13039/501100000368, 10.13039/100010269, 10.13039/100010269", "url": "https://doi.org/10.1073/pnas.1504162112", "pdfUrl": null, "abstract": "Significance We reveal a novel and highly significant change in how items are held in mind in healthy aging. Using smartphones, data were collected from 29,631 participants, between the ages of 18–69 y. We compare the ability to exclude distractors when items are entered into working memory (WM) (encoding distraction, ED) and when items are held in mind (delay distraction, DD). In older adults, WM in the absence of distraction was more similar to ED exclusion than DD exclusion. A greater reliance on focused attention during encoding may reflect compensation for the more pronounced deterioration we observed in DD exclusion in older age. This can inform other areas of cognition and strategies to ameliorate or manage debilitating age-related cognitive decline.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1136/bmjgh-2022-009472", "doi": "10.1136/bmjgh-2022-009472", "title": "A framework for managing health research capacity strengthening consortia: addressing tensions and enhancing capacity outcomes", "publicationYear": 2022, "publicationDate": "2022-10", "type": "journal-article", "publisher": "BMJ", "containerTitle": "BMJ Global Health", "volume": "7", "issue": "10", "page": "e009472", "issn": "2059-7908", "isbn": null, "authors": "Nadia Tagoe, Justin Pulford, Sam Kinyanjui, Sassy Molyneux", "authorCount": 4, "firstAuthorAffiliation": "Office of Grants and Research, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana", "isReferencedByCount": 8, "referenceCount": 79, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust, Wellcome Trust, UK government, DELTAS Africa Initiative", "funderIds": "10.13039/100010269, 10.13039/100010269, 10.13039/100013986", "url": "https://doi.org/10.1136/bmjgh-2022-009472", "pdfUrl": null, "abstract": "There has been a steady increase in health research capacity strengthening (HRCS) consortia and programmes. However, their structures and management practices and the effect on the capacity strengthening outcomes have been underexamined. We conducted a case study involving three HRCS consortia where we critically examined the consortia’s decision-making processes, strategies for resolving management tensions and the potential implications for consortia outcomes. We conducted 44 in-depth interviews with a range of consortia members and employed the framework method to analyse the data. We assessed the extent to which consortia’s management practices and strategies enabled or hindered research capacity strengthening using a capacity development lens. At the heart of consortium management is how tensions are navigated and the resolution strategies adopted. This study demonstrates that the management strategies adopted by consortia have capacity strengthening consequences. When deciding on tension management strategies, trade-offs often occur, sometimes to the detriment of capacity strengthening aims. When management strategies align with capacity development principles, consortium management processes become capacity strengthening mechanisms for participating individuals and institutions. Such alignment enhances programme effectiveness and value for money. Drawing on these findings, we propose an evidence-informed management framework that consortia leaders can use in practice to support decision-making to optimise research capacity gains. Considering the increasing investment in HRCS consortia, leveraging all consortium processes towards capacity strengthening will maximise the returns on investments made.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.3390/genes10100741", "doi": "10.3390/genes10100741", "title": "Status of Insecticide Resistance and Its Mechanisms in Anopheles gambiae and Anopheles coluzzii Populations from Forest Settings in South Cameroon", "publicationYear": 2019, "publicationDate": "2019-09-24", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Genes", "volume": "10", "issue": "10", "page": "741", "issn": "2073-4425", "isbn": null, "authors": "Roland Bamou, Nadège Sonhafouo-Chiana, Konstantinos Mavridis, Timoléon Tchuinkam, Charles S. Wondji, John Vontas, Christophe Antonio-Nkondjio", "authorCount": 7, "firstAuthorAffiliation": "Vector Borne Diseases Laboratory of the Applied Biology and Ecology Research Unit (VBID-URBEA), Department of Animal Biology, Faculty of Science of the University of Dschang, Dschang P.O. Box 067, Cameroon", "isReferencedByCount": 45, "referenceCount": 63, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust, European Union’s Horizon 2020 research and innovation programme", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.3390/genes10100741", "pdfUrl": null, "abstract": "A key factor affecting malaria vector control efforts in Cameroon is the rapid expansion of insecticide resistance in Anopheles gambiae s.l (An. gambiae) populations; however, mechanisms involved in insecticide resistance in forest mosquito populations are still not well documented yet. The present study was conducted to screen molecular mechanisms conferring insecticide resistance in An. gambiae s.l. populations from the South Cameroon forest region. WHO bioassays were conducted with F0 An. gambiae females aged three to four days from forest (Sangmelima, Nyabessan, and Mbandjock) and urban sites (Yaoundé (Bastos and Nkolondom)), against pyrethroids (permethrin 0.75% and deltamethrin 0.05%) and carbamates (bendiocarb 0.1%). Members of the An. Gambiae s.l. species complex were identified using molecular diagnostic tools. TaqMan assays were used to screen for target site mutations. The expression profiles of eight genes implicated in insecticide resistance were assessed using RT-qPCR. Cuticle hydrocarbon lipids were measured to assess their potential implication in insecticide resistance. Both An. Gambiae and An. coluzzii were detected. An. gambiae was highly prevalent in Sangmelima, Nyabessan, Mbandjock, and Nkolondom. An. coluzzii was the only species found in the Yaoundé city center (Bastos). Low mortality rate to both pyrethroids and bendiocarb was recorded in all sites. High frequency of L1014F allele (75.32–95.82%) and low frequencies of L1014S (1.71–23.05%) and N1575Y (5.28–12.87%) were recorded. The G119S mutation (14.22–35.5%) was detected for the first time in An. gambiae populations from Cameroon. This mutation was rather absent from An. coluzzii populations. The detoxification genes Cyp6m2, Cyp9k1, Cyp6p4, Cyp6z1, as well as Cyp4g16 which catalyzes epicuticular hydrocarbon biosynthesis, were found to be overexpressed in at least one population. The total cuticular hydrocarvbon content, a proxy of cuticular resistance, did not show a pattern associated with pyrethroid resistance in these populations. The rapid emergence of multiple resistance mechanisms in An. Gambiae s.l. population from the South Cameroon forest region is of big concern and could deeply affect the sustainability of insecticide-based interventions strategies in this region.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.3390/brainsci10100760", "doi": "10.3390/brainsci10100760", "title": "Glycyrrhizin Blocks the Detrimental Effects of HMGB1 on Cortical Neurogenesis after Traumatic Neuronal Injury", "publicationYear": 2020, "publicationDate": "2020-10-21", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Brain Sciences", "volume": "10", "issue": "10", "page": "760", "issn": "2076-3425", "isbn": null, "authors": "Susruta Manivannan, Balkis Harari, Maryam Muzaffar, Omar Elalfy, Sameera Hettipathirannahelage, Zoe James, Feras Sharouf, Chloe Ormonde, Mouhamed Alsaqati, William Gray, Malik Zaben", "authorCount": 11, "firstAuthorAffiliation": "Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Cathays, Cardiff CF24 4HQ, UK", "isReferencedByCount": 12, "referenceCount": 71, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Royal College of Surgeons of England, Wellcome Trust, Rhiannon Jade-Smith Trust", "funderIds": "10.13039/501100000297, 10.13039/100010269", "url": "https://doi.org/10.3390/brainsci10100760", "pdfUrl": null, "abstract": "Despite medical advances, neurological recovery after severe traumatic brain injury (TBI) remains poor. Elevated levels of high mobility group box protein-1 (HMGB1) are associated with poor outcomes; likely via interaction with receptors for advanced-glycation-end-products (RAGE). We examined the hypothesis that HMGB1 post-TBI is anti-neurogenic and whether this is pharmacologically reversible. Post-natal rat cortical mixed neuro-glial cell cultures were subjected to needle-scratch injury and examined for HMGB1-activation/neuroinflammation. HMGB1-related genes/networks were examined using genome-wide RNA-seq studies in cortical perilesional tissue samples from adult mice. Post-natal rat cortical neural stem/progenitor cell cultures were generated to quantify effects of injury-condition medium (ICM) on neurogenesis with/without RAGE antagonist glycyrrhizin. Needle-injury upregulated TNF-α/NOS-2 mRNA-expressions at 6 h, increased proportions of activated microglia, and caused neuronal loss at 24 h. Transcriptome analysis revealed activation of HMGB1 pathway genes/canonical pathways in vivo at 24 h. A 50% increase in HMGB1 protein expression, and nuclear-to-cytoplasmic translocation of HMGB1 in neurons and microglia at 24 h post-injury was demonstrated in vitro. ICM reduced total numbers/proportions of neuronal cells, but reversed by 0.5 μM glycyrrhizin. HMGB1 is activated following in vivo post mechanical injury, and glycyrrhizin alleviates detrimental effects of ICM on cortical neurogenesis. Our findings highlight glycyrrhizin as a potential therapeutic agent post-TBI.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1155/2019/1907426", "doi": "10.1155/2019/1907426", "title": "Serum Exosomal miRNAs Are Associated with Active Pulmonary Tuberculosis", "publicationYear": 2019, "publicationDate": "2019-02-11", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Disease Markers", "volume": "2019", "issue": null, "page": "1-9", "issn": "0278-0240, 1875-8630", "isbn": null, "authors": "Shamila D. Alipoor, Payam Tabarsi, Mohammad Varahram, Mehrnaz Movassaghi, Mehdi Kazempour Dizaji, Gert Folkerts, Johan Garssen, Ian M. Adcock, Esmaeil Mortaz", "authorCount": 9, "firstAuthorAffiliation": "Institute of Medical Biotechnology, Molecular Medicine Department, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran", "isReferencedByCount": 63, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Iran National Science Foundation, Iran National Science Foundation, Welcome Trust, Welcome Trust", "funderIds": "10.13039/501100003968, 10.13039/501100003968, 10.13039/100010269, 10.13039/100010269", "url": "https://doi.org/10.1155/2019/1907426", "pdfUrl": "http://downloads.hindawi.com/journals/dm/2019/1907426.pdf", "abstract": "Introduction. Tuberculosis (TB) remains a major threat to human health. Due to the limited accuracy of the current TB diagnostic tests, it is critical to determine novel biomarkers for this disease. Circulating exosomes have been used as diagnostic biomarkers in various diseases. Objective of the Study. In this pilot study, we examined the expression of miRNAs as biomarker candidates for the diagnosis of TB infection. Methods. Serum-derived exosomes were isolated from TB patients and matched control subjects. The expression of miR-484, miR-425, and miR-96 was examined by RT-PCR methods. Results. The expression of miR-484, miR-425, and miR-96 were significantly increased in serum of TB patients which correlated with the TB infection level. A receiver operating characteristic (ROC) curve analysis showed the diagnostic potency of each individual serum exosomal miRNA with an area under the curve AUC=0.72 for miR-484 (p&lt;0.05), 0.66 for miR-425 (p&lt;0.05), and 0.62 for miR-96 (p&lt;0.05). Conclusion. These results demonstrate that exosomal miRNAs have diagnostic potential in active tuberculosis. The diagnostic power may be improved when combined with conventional diagnostic markers.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1210/clinem/dgaa766", "doi": "10.1210/clinem/dgaa766", "title": "11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension", "publicationYear": 2021, "publicationDate": "2021-01-01", "type": "journal-article", "publisher": "The Endocrine Society", "containerTitle": "The Journal of Clinical Endocrinology &amp; Metabolism", "volume": "106", "issue": "1", "page": "174-187", "issn": "0021-972X, 1945-7197", "isbn": null, "authors": "Rowan S Hardy, Hannah Botfield, Keira Markey, James L Mitchell, Zerin Alimajstorovic, Connar S J Westgate, Michael Sagmeister, Rebecca J Fairclough, Ryan S Ottridge, Andreas Yiangou, Karl-Heinz H Storbeck, Angela E Taylor, Lorna C Gilligan, Wiebke Arlt, Paul M Stewart, Jeremy W Tomlinson, Susan P Mollan, Gareth G Lavery, Alexandra J Sinclair", "authorCount": 19, "firstAuthorAffiliation": "Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK", "isReferencedByCount": 58, "referenceCount": 48, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Medical Research Council Asset Sharing Scheme, UK, Medical Research Council Asset Sharing Scheme, UK, National Institute for Health Research, Wellcome Trust, Academy of Medical Sciences UK, Versus Arthritis, National Institute for Health Research", "funderIds": "10.13039/501100000272, 10.13039/100010269, 10.13039/501100012041, 10.13039/501100000272", "url": "https://doi.org/10.1210/clinem/dgaa766", "pdfUrl": "http://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgaa766/34473970/dgaa766.pdf", "abstract": "Abstract Background The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) determines prereceptor metabolism and activation of glucocorticoids within peripheral tissues. Its dysregulation has been implicated in a wide array of metabolic diseases, leading to the development of selective 11β-HSD1 inhibitors. We examined the impact of the reversible competitive 11β-HSD1 inhibitor, AZD4017, on the metabolic profile in an overweight female cohort with idiopathic intracranial hypertension (IIH). Methods We conducted a UK multicenter phase II randomized, double-blind, placebo-controlled trial of 12-week treatment with AZD4017. Serum markers of glucose homeostasis, lipid metabolism, renal and hepatic function, inflammation and androgen profiles were determined and examined in relation to changes in fat and lean mass by dual-energy X-ray absorptiometry. Results Patients receiving AZD4017 showed significant improvements in lipid profiles (decreased cholesterol, increased high-density lipoprotein [HDL] and cholesterol/HDL ratio), markers of hepatic function (decreased alkaline phosphatase and gamma-glutamyl transferase), and increased lean muscle mass (1.8%, P &amp;lt; .001). No changes in body mass index, fat mass, and markers of glucose metabolism or inflammation were observed. Patients receiving AZD4017 demonstrated increased levels of circulating androgens, positively correlated with changes in total lean muscle mass. Conclusions These beneficial metabolic changes represent a reduction in risk factors associated with raised intracranial pressure and represent further beneficial therapeutic outcomes of 11β-HSD1 inhibition by AZD4017 in this overweight IIH cohort. In particular, beneficial changes in lean muscle mass associated with AZD4017 may reflect new applications for this nature of inhibitor in the management of conditions such as sarcopenia.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.12688/wellcomeopenres.24117.1", "doi": "10.12688/wellcomeopenres.24117.1", "title": "Digital mental health interventions for adolescents and young people (10–24 years) in Africa: A protocol for a systematic review of mental health outcomes, engagement, and equity considerations", "publicationYear": 2025, "publicationDate": "2025-07-04", "type": "journal-article", "publisher": "F1000 Research Ltd", "containerTitle": "Wellcome Open Research", "volume": "10", "issue": null, "page": "331", "issn": "2398-502X", "isbn": null, "authors": "Aggrey Gisiora Mokaya, Nondumiso Michelle Dlamini, Syethemba Nkosi, Mpilonhle Thembinkosi Nzuza, Thandeka Smith, Grace Nduku Wambua, Xanthe Hunt, Alan Stein, Nothando Ngwenya", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 39, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.12688/wellcomeopenres.24117.1", "pdfUrl": "https://wellcomeopenresearch.org/articles/10-331/v1/pdf", "abstract": "Background Adolescents and young people (AYP) aged 10–24 years in Africa experience a high burden of mental health disorders but face significant barriers to accessing care, including a severe shortage of mental health professionals, stigma, and limited integration of mental health services into primary healthcare. Digital mental health interventions (DMHIs) offer a promising avenue to bridge these gaps by providing accessible, scalable, and potentially equitable support. However, little is known about the effectiveness, acceptability, and equity impacts of these interventions among African AYP. Objective This systematic review aims to identify, characterize, and synthesize evidence on DMHIs targeting adolescents and young people in Africa, focusing on mental health outcomes, engagement, feasibility, and equity considerations. Methods We will search PubMed, Scopus, Web of Science, and EBSCOhost databases, as well as the PsyberGuide repository, for empirical studies published between January 1, 2015, and April 3, 2025. Eligible studies must evaluate a digital mental health intervention among AYP aged 10–24 years living in Africa. Study designs will include randomized controlled trials, quasi-experimental studies, observational studies, and mixed-methods studies. Outcomes of interest include mental health symptom reduction (depression, anxiety, stress), psychological well-being, engagement, feasibility, acceptability, and equity-related factors such as gender inclusivity and digital access. Risk of bias will be assessed using RoB 2 and ROBINS-I tools, and evidence quality will be rated using the GRADE approach. Quantitative synthesis will be conducted where feasible, otherwise narrative synthesis will be employed. Conclusion This review will provide a comprehensive synthesis of available evidence on DMHIs for adolescents and young people in Africa, offering critical insights into their effectiveness, feasibility, and contribution to promoting mental health equity. The findings aim to inform the development, implementation, and policy integration of digital mental health strategies tailored to young populations in diverse African contexts.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1136/bmjopen-2019-035045", "doi": "10.1136/bmjopen-2019-035045", "title": "Prognostic models for predicting in-hospital paediatric mortality in resource-limited countries: a systematic review", "publicationYear": 2020, "publicationDate": "2020-10", "type": "journal-article", "publisher": "BMJ", "containerTitle": "BMJ Open", "volume": "10", "issue": "10", "page": "e035045", "issn": "2044-6055, 2044-6055", "isbn": null, "authors": "Morris Ogero, Rachel Jelagat Sarguta, Lucas Malla, Jalemba Aluvaala, Ambrose Agweyu, Mike English, Nelson Owuor Onyango, Samuel Akech", "authorCount": 8, "firstAuthorAffiliation": "School of Mathematics, University of Nairobi College of Biological and Physical Sciences, Nairobi, Kenya", "isReferencedByCount": 21, "referenceCount": 78, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "The Wellcome Trust, The Wellcome Trust, The Wellcome Trust, The Wellcome Trust", "funderIds": "10.13039/100010269, 10.13039/100010269, 10.13039/100010269, 10.13039/100010269", "url": "https://doi.org/10.1136/bmjopen-2019-035045", "pdfUrl": null, "abstract": "Objectives To identify and appraise the methodological rigour of multivariable prognostic models predicting in-hospital paediatric mortality in low-income and middle-income countries (LMICs). Design Systematic review of peer-reviewed journals. Data sources MEDLINE, CINAHL, Google Scholar and Web of Science electronic databases since inception to August 2019. Eligibility criteria We included model development studies predicting in-hospital paediatric mortality in LMIC. Data extraction and synthesis This systematic review followed the Checklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies framework. The risk of bias assessment was conducted using Prediction model Risk of Bias Assessment Tool (PROBAST). No quantitative summary was conducted due to substantial heterogeneity that was observed after assessing the studies included. Results Our search strategy identified a total of 4054 unique articles. Among these, 3545 articles were excluded after review of titles and abstracts as they covered non-relevant topics. Full texts of 509 articles were screened for eligibility, of which 15 studies reporting 21 models met the eligibility criteria. Based on the PROBAST tool, risk of bias was assessed in four domains; participant, predictors, outcome and analyses. The domain of statistical analyses was the main area of concern where none of the included models was judged to be of low risk of bias. Conclusion This review identified 21 models predicting in-hospital paediatric mortality in LMIC. However, most reports characterising these models are of poor quality when judged against recent reporting standards due to a high risk of bias. Future studies should adhere to standardised methodological criteria and progress from identifying new risk scores to validating or adapting existing scores. PROSPERO registration number CRD42018088599.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1242/bio.058812", "doi": "10.1242/bio.058812", "title": "The <i>Drosophila</i> orthologue of the primary ciliary dyskinesia-associated gene, <i>DNAAF3</i> , is required for axonemal dynein assembly", "publicationYear": 2021, "publicationDate": "2021-10-15", "type": "journal-article", "publisher": "The Company of Biologists", "containerTitle": "Biology Open", "volume": "10", "issue": "10", "page": null, "issn": "2046-6390", "isbn": null, "authors": "Petra zur Lage, Zhiyan Xi, Jennifer Lennon, Iain Hunter, Wai Kit Chan, Alfonso Bolado Carrancio, Alex von Kriegsheim, Andrew P. Jarman", "authorCount": 8, "firstAuthorAffiliation": "Centre for Discovery Brain Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK EH8 9XD, UK", "isReferencedByCount": 12, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0", "funderNames": "Biotechnology and Biological Sciences Research Council, Wellcome Trust", "funderIds": "10.13039/501100000268, 10.13039/100010269", "url": "https://doi.org/10.1242/bio.058812", "pdfUrl": "http://journals.logists.com/bio/bio/article-pdf/doi/10.1242/bio.058812/2106350/bio058812.pdf", "abstract": "ABSTRACT Ciliary motility is powered by a suite of highly conserved axoneme-specific dynein motor complexes. In humans, the impairment of these motors through mutation results in the disease primary ciliary dyskinesia (PCD). Studies in Drosophila have helped to validate several PCD genes whose products are required for cytoplasmic pre-assembly of axonemal dynein motors. Here we report the characterisation of the Drosophila orthologue of the less-known assembly factor DNAAF3. This gene, CG17669 (Dnaaf3), is expressed exclusively in developing mechanosensory chordotonal (Ch) neurons and the cells that generate spermatozoa, The only two Drosophila cell types bearing cilia/flagella containing dynein motors. Mutation of Dnaaf3 results in larvae that are deaf and adults that are uncoordinated, indicating defective Ch neuron function. The mutant Ch neuron cilia of the antenna specifically lack dynein arms, while Ca imaging in larvae reveals a complete loss of Ch neuron response to vibration stimulus, confirming that mechanotransduction relies on ciliary dynein motors. Mutant males are infertile with immotile sperm whose flagella lack dynein arms and show axoneme disruption. Analysis of proteomic changes suggest a reduction in heavy chains of all axonemal dynein forms, consistent with an impairment of dynein pre-assembly.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.3390/genes10100790", "doi": "10.3390/genes10100790", "title": "The G119S Acetylcholinesterase (Ace-1) Target Site Mutation Confers Carbamate Resistance in the Major Malaria Vector Anopheles gambiae from Cameroon: A Challenge for the Coming IRS Implementation", "publicationYear": 2019, "publicationDate": "2019-10-11", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Genes", "volume": "10", "issue": "10", "page": "790", "issn": "2073-4425", "isbn": null, "authors": "Emmanuel Elanga-Ndille, Lynda Nouage, Cyrille Ndo, Achille Binyang, Tatiane Assatse, Daniel Nguiffo-Nguete, Doumani Djonabaye, Helen Irving, Billy Tene-Fossog, Charles S. Wondji", "authorCount": 10, "firstAuthorAffiliation": "Centre for Research in Infectious Diseases (CRID), P.O. BOX 13591 Yaoundé, Cameroon", "isReferencedByCount": 48, "referenceCount": 63, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.3390/genes10100790", "pdfUrl": null, "abstract": "Growing resistance is reported to carbamate insecticides in malaria vectors in Cameroon. However, the contribution of acetylcholinesterase (Ace-1) to this resistance remains uncharacterised. Here, we established that the G119S mutation is driving resistance to carbamates in Anopheles gambiae populations from Cameroon. Insecticide bioassay on field-collected mosquitoes from Bankeng, a locality in southern Cameroon, showed high resistance to the carbamates bendiocarb (64.8% ± 3.5% mortality) and propoxur (55.71% ± 2.9%) but a full susceptibility to the organophosphate fenitrothion. The TaqMan genotyping of the G119S mutation in field-collected adults revealed the presence of this resistance allele (39%). A significant correlation was observed between the Ace-1R and carbamate resistance at allelic ((bendiocarb; odds ratio (OR) = 75.9; p &lt; 0.0001) and (propoxur; OR = 1514; p &lt; 0.0001)) and genotypic (homozygote resistant vs. homozygote susceptible (bendiocarb; OR = 120.8; p &lt; 0.0001) and (propoxur; OR = 3277; p &lt; 0.0001)) levels. Furthermore, the presence of the mutation was confirmed by sequencing an Ace-1 portion flanking codon 119. The cloning of this fragment revealed a likely duplication of Ace-1 in Cameroon as mosquitoes exhibited at least three distinct haplotypes. Phylogenetic analyses showed that the predominant Ace-1R allele is identical to that from West Africa suggesting a recent introduction of this allele in Central Africa from the West. The spread of this Ace-1R represents a serious challenge to future implementation of indoor residual spraying (IRS)-based interventions using carbamates or organophosphates in Cameroon.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1017/s0031182023000677", "doi": "10.1017/s0031182023000677", "title": "Patterns and drivers of vector-borne microparasites in a classic metapopulation", "publicationYear": 2023, "publicationDate": "2023-09", "type": "journal-article", "publisher": "Cambridge University Press (CUP)", "containerTitle": "Parasitology", "volume": "150", "issue": "10", "page": "866-882", "issn": "0031-1820, 1469-8161", "isbn": null, "authors": "Laura S. Mackenzie, Xavier Lambin, Emma Bryce, Claire L. Davies, Richard Hassall, Ali A. M. Shati, Chris Sutherland, Sandra E. Telfer", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 75, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust, Wellcome Trust, Biotechnology and Biological Sciences Research Council", "funderIds": "10.13039/100010269, 10.13039/100010269, 10.13039/501100000268", "url": "https://doi.org/10.1017/s0031182023000677", "pdfUrl": null, "abstract": "AbstractMany organisms live in fragmented populations, which has profound consequences on the dynamics of associated parasites. Metapopulation theory offers a canonical framework for predicting the effects of fragmentation on spatiotemporal host–parasite dynamics. However, empirical studies of parasites in classical metapopulations remain rare, particularly for vector-borne parasites. Here, we quantify spatiotemporal patterns and possible drivers of infection probability for several ectoparasites (fleas, Ixodes trianguliceps and Ixodes ricinus) and vector-borne microparasites (Babesia microti, Bartonella spp., Hepatozoon spp.) in a classically functioning metapopulation of water vole hosts. Results suggest that the relative importance of vector or host dynamics on microparasite infection probabilities is related to parasite life-histories. Bartonella, a microparasite with a fast life-history, was positively associated with both host and vector abundances at several spatial and temporal scales. In contrast, B. microti, a tick-borne parasite with a slow life-history, was only associated with vector dynamics. Further, we provide evidence that life-history shaped parasite dynamics, including occupancy and colonization rates, in the metapopulation. Lastly, our findings were consistent with the hypothesis that landscape connectivity was determined by distance-based dispersal of the focal hosts. We provide essential empirical evidence that contributes to the development of a comprehensive theory of metapopulation processes of vector-borne parasites.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1098/rstb.2024.0339", "doi": "10.1098/rstb.2024.0339", "title": "Assessment of the pharmacodynamic properties of antimalarial drugs", "publicationYear": 2026, "publicationDate": "2026-04-30", "type": "journal-article", "publisher": "The Royal Society", "containerTitle": "Philosophical Transactions B", "volume": "381", "issue": "1949", "page": null, "issn": "0962-8436, 1471-2970", "isbn": null, "authors": "Nicholas John White", "authorCount": 1, "firstAuthorAffiliation": "Mahidol University 1 , ,", "isReferencedByCount": 0, "referenceCount": 107, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.1098/rstb.2024.0339", "pdfUrl": "https://royalsocietypublishing.org/rstb/article-pdf/doi/10.1098/rstb.2024.0339/6135527/rstb.2024.0339.pdf", "abstract": "Abstract Quantifying therapeutic responses in clinical malaria is easier than for most other infections as the intraerythrocytic parasites can be counted by microscopy or estimated using quantitative PCR. In treating the blood-stage of malaria, between 107 and 1013 parasites undergo a first-order decline in densities at a rate determined by the concentrations and potency of the antimalarial drug. A simple conceptual framework based on total intravascular parasite biomass and standard sigmoid concentration–effect relationships for parasite killing explains most, but not all, aspects of antimalarial therapeutic responses, and it has proved very useful in designing chemoprevention and treatment regimens and in understanding the selection and spread of resistance. Drugs acting on younger circulating ring-stage asexual parasites (artemisinins, cipargamin, ganaplacide) provide rapid parasite clearance, which translates into faster clinical recoveries and a life-saving benefit in severe malaria. Artemisinin-sensitive Plasmodium falciparum densities decline with a half-life (PC1/2) of usually less than 5 h. Many antimalarial drugs are eliminated slowly and provide protracted exposures, which allows full treatment to be administered in 3 days, and also provides chemosuppression of newly acquired infections for 1 month. Greater availability of drug measurement in malaria-endemic areas would facilitate the field assessment of antimalarial drugs. This article is part of the Theo Murphy meeting issue ‘Evaluating anti-infective drugs’.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.3390/antiox10071030", "doi": "10.3390/antiox10071030", "title": "Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs", "publicationYear": 2021, "publicationDate": "2021-06-25", "type": "journal-article", "publisher": "MDPI AG", "containerTitle": "Antioxidants", "volume": "10", "issue": "7", "page": "1030", "issn": "2076-3921", "isbn": null, "authors": "Tabitha Jenkins, Jerome Gouge", "authorCount": 2, "firstAuthorAffiliation": "Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, UK", "isReferencedByCount": 54, "referenceCount": 133, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust", "funderIds": "10.13039/100010269", "url": "https://doi.org/10.3390/antiox10071030", "pdfUrl": null, "abstract": "Reactive oxygen species (ROS) play an important role in cell proliferation and differentiation. They are also by-products of aerobic living conditions. Their inherent reactivity poses a threat for all cellular components. Cells have, therefore, evolved complex pathways to sense and maintain the redox balance. Among them, Nrf2 (Nuclear factor erythroid 2-related factor 2) plays a crucial role: it is activated under oxidative conditions and is responsible for the expression of the detoxification machinery and antiapoptotic factors. It is, however, a double edge sword: whilst it prevents tumorigenesis in healthy cells, its constitutive activation in cancer promotes tumour growth and metastasis. In addition, recent data have highlighted the importance of Nrf2 in evading programmed cell death. In this review, we will focus on the activation of the Nrf2 pathway in the cytoplasm, the molecular basis underlying Nrf2 binding to the DNA, and the dysregulation of this pathway in cancer, before discussing how Nrf2 contributes to the prevention of apoptosis and ferroptosis in cancer and how it is likely to be linked to detoxifying enzymes containing selenium.", "subject": null, "language": "en", "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.3389/fmmed.2024.1345510", "doi": "10.3389/fmmed.2024.1345510", "title": "Combined analysis of host IFN-γ, IL-2 and IP-10 as potential LTBI biomarkers in ESAT-6/CFP-10 stimulated blood", "publicationYear": 2024, "publicationDate": "2024-01-26", "type": "journal-article", "publisher": "Frontiers Media SA", "containerTitle": "Frontiers in Molecular Medicine", "volume": "4", "issue": null, "page": null, "issn": "2674-0095", "isbn": null, "authors": "Antony M. Rapulana, Thabo Mpotje, Omolara O. Baiyegunhi, Hlumani Ndlovu, Theresa K. Smit, Timothy D. McHugh, Mohlopheni J. Marakalala", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 12, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Bill and Melinda Gates Foundation, Wellcome Trust, National Research Foundation, South African Medical Research Council", "funderIds": "10.13039/100000865, 10.13039/100010269, 10.13039/501100001321, 10.13039/501100001322", "url": "https://doi.org/10.3389/fmmed.2024.1345510", "pdfUrl": null, "abstract": "Background: Accurate diagnosis of latent tuberculosis infected (LTBI) individuals is important in identifying individuals at risk of developing active tuberculosis. Current diagnosis of LTBI routinely relies on the detection and measurement of immune responses using the Tuberculin Skin Test (TST) and interferon gamma release assays (IGRAs). However, IGRA, which detects Mycobacterium tuberculosis specific IFN-γ, is associated with frequent indeterminate results, particularly in immunosuppressed patients. There is a need to identify more sensitive LTBI point of care diagnostic biomarkers. The aim of this study was to assess the validity of early secreted antigen target 6 kDa (ESAT-6) and culture filtrate protein 10 (CFP-10) stimulated plasma to identify additional cytokines and chemokines as potential biomarkers of LTBI.Method: The levels of 27 cytokines and chemokines were measured by Bio-Plex Pro cytokine, chemokine and growth factor assay in ESAT-6 and CFP-10 co-stimulated plasma from 20 LTBI participants with positive IGRA (Quantiferon TB Gold plus) and 20 healthy controls with negative IGRA. Traditional ELISA was used to validate the abundance of the best performing markers in 70 LTBI and 72 healthy participants. All participants were HIV negative.Results: We found that Interleukin 1 receptor antagonist (IL1ra) (p = 0.0056), Interleukin 2 (IL-2) (p &amp;lt; 0.0001), Interleukin 13 (IL-13) (p &amp;lt; 0.0001), Interferon gamma-induced protein 10 (IP-10) (p &amp;lt; 0.0001), and Macrophage inflammatory protein-1 beta (MIP1b) (p = 0.0010) were significantly higher in stimulated plasma of LTBI compared to healthy individuals. Stimulated plasma IL-2 (cutoff 100 pg/mL), IP-10 (cutoff 300 pg/mL) and IL-13 (5 pg/mL) showed potential in diagnosing LTBI with PPV = 100%, 0.89.4%, and 80.9% and NPV = 86.9%, 0.85.7%, and 84.2%, respectively.Conclusion: Our data shows that co-stimulating whole blood with ESAT-6 and CFP-10 may help distinguish LTBI from healthy individuals. We also identified IL-2 and IP-10 as potential biomarkers that could be added to the currently used IFN-γ release assays in detection of LTBI.", "subject": null, "language": null, "_run_id": "aTzP2pM2q0vxihgcj", "_dataset_id": "8BOKWayHdxQdRkImt"}
{"paperId": "10.1093/sleep/14.3.226", "doi": "10.1093/sleep/14.3.226", "title": "Neuroendocrine Evaluation in Kleine-Levin Syndrome: Evidence of Reduced Doparrlinergic Tone during Periods of Hypersomnolence", "publicationYear": 1991, "publicationDate": "1991-05-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Sleep", "volume": null, "issue": null, "page": null, "issn": "1550-9109", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/sleep/14.3.226", "pdfUrl": "http://academic.oup.com/sleep/article-pdf/14/3/226/8661149/140305.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1373/clinchem.2005.052183", "doi": "10.1373/clinchem.2005.052183", "title": "Addition of a Homologous Internal Control to a Real-Time PCR Assay for Detection of Bordetella pertussis", "publicationYear": 2005, "publicationDate": "2005-12-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Clinical Chemistry", "volume": "51", "issue": "12", "page": "2404-2406", "issn": "0009-9147, 1530-8561", "isbn": null, "authors": "Christoph Koidl, Michael Bozic, Jörg Berg, Markus Stöcher, Gerhard Mühlbauer, Egon Marth, Harald H Kessler", "authorCount": 7, "firstAuthorAffiliation": "Molecular Diagnostics Laboratory, Institute of Hygiene, Medical University of Graz, Graz, Austria", "isReferencedByCount": 3, "referenceCount": 13, "isOpenAccess": true, "licenseUrl": "https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1373/clinchem.2005.052183", "pdfUrl": "http://academic.oup.com/clinchem/article-pdf/51/12/2404/32684585/clinchem2404.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/jeclap/lpr081", "doi": "10.1093/jeclap/lpr081", "title": "For the Better: The Reform of the Finnish Competition Act", "publicationYear": 2012, "publicationDate": "2012-08-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Journal of European Competition Law &amp; Practice", "volume": "3", "issue": "4", "page": "404-408", "issn": "2041-7764, 2041-7772", "isbn": null, "authors": "N. Hukkinen, L. Peltonen", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/jeclap/lpr081", "pdfUrl": "http://academic.oup.com/jeclap/article-pdf/3/4/404/5115371/lpr081.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/sw/19.6.659", "doi": "10.1093/sw/19.6.659", "title": "New Federalism and the cities: a double cross", "publicationYear": 1974, "publicationDate": "1974-11", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Social Work", "volume": null, "issue": null, "page": null, "issn": "1545-6846", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/sw/19.6.659", "pdfUrl": "http://academic.oup.com/sw/article-pdf/19/6/659/5242156/19-6-659.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/rpd/ncq578", "doi": "10.1093/rpd/ncq578", "title": "226Ra, 232Th and 40K radionuclides enhancement rate and dose assessment for residues of lignite-fired thermal power plants in Turkey", "publicationYear": 2011, "publicationDate": "2011-11-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Radiation Protection Dosimetry", "volume": "147", "issue": "4", "page": "548-554", "issn": "0144-8420, 1742-3406", "isbn": null, "authors": "A. Parmaksiz, P. Arikan, M. Vural, E. Yeltepe, I. Tukenmez", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 4, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/rpd/ncq578", "pdfUrl": "http://academic.oup.com/rpd/article-pdf/147/4/548/4615260/ncq578.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/nq/11-3-97", "doi": "10.1093/nq/11-3-97", "title": "MANUSCRIPT TEXTS OF POEMS BY THE EARL OF DORSET AND WILLIAM CONGREVE", "publicationYear": 1964, "publicationDate": "1964-03-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Notes and Queries", "volume": "11", "issue": "3", "page": "97-100", "issn": "1471-6941, 0029-3970", "isbn": null, "authors": "J. A. V. CHAPPLE", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/nq/11-3-97", "pdfUrl": "http://academic.oup.com/nq/article-pdf/11/3/97/21723712/11-3-97.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/nq/183.1.7", "doi": "10.1093/nq/183.1.7", "title": "Notes on the 'Oxford English Dictionary.'", "publicationYear": 1942, "publicationDate": "1942-07-04", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Notes and Queries", "volume": "183", "issue": "1", "page": "7-9", "issn": "1471-6941, 0029-3970", "isbn": null, "authors": "J. Ardagh", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/nq/183.1.7", "pdfUrl": "http://academic.oup.com/nq/article-pdf/183/1/7/19978026/7.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/ajlh/52.2.183", "doi": "10.1093/ajlh/52.2.183", "title": "The Origin of Privacy as a Legal Value: A Reflection on Roman and English Law", "publicationYear": 2012, "publicationDate": "2012-04", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "American Journal of Legal History", "volume": "52", "issue": "2", "page": "183-201", "issn": "0002-9319, 2161-797X", "isbn": null, "authors": "Bernardo Periñán", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/ajlh/52.2.183", "pdfUrl": "http://academic.oup.com/ajlh/article-pdf/52/2/183/5072566/52-2-183.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/nq/s1-iv.110.442d", "doi": "10.1093/nq/s1-iv.110.442d", "title": "Round towers at Bhaugulpore", "publicationYear": 1851, "publicationDate": "1851-11-06", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Notes and Queries", "volume": "s1-IV", "issue": "110", "page": "442-442", "issn": "1471-6941, 0029-3970", "isbn": null, "authors": "De Camera", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/nq/s1-iv.110.442d", "pdfUrl": "http://academic.oup.com/nq/article-pdf/s1-IV/110/442/21213712/442-d.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/jcag/gwy009.214", "doi": "10.1093/jcag/gwy009.214", "title": "A214 A COMPARISON OF REAL-WORLD UTILIZATION PATTERNS OF INNOVATOR AND BIOSIMILAR INFLIXIMAB: A PRESCRIPTION CLAIMS DATA SUBGROUP ANALYSIS OF GERMAN GASTROENTEROLOGISTS", "publicationYear": 2018, "publicationDate": "2018-03-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Journal of the Canadian Association of Gastroenterology", "volume": "1", "issue": "suppl_2", "page": "317-318", "issn": "2515-2084, 2515-2092", "isbn": null, "authors": "E Ewara, V Jairath, M Marrache, X Baraliakos", "authorCount": 4, "firstAuthorAffiliation": "Janssen Inc., Toronto, ON, Canada", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/jcag/gwy009.214", "pdfUrl": "http://academic.oup.com/jcag/article-pdf/1/suppl_2/317/28514439/gwy009.214.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/oxfordjournals.aje.a118864", "doi": "10.1093/oxfordjournals.aje.a118864", "title": "STUDIES ON SYPHILIS IN THE EASTERN HEALTH DISTRICT OF BALTIMORE CITY", "publicationYear": 1943, "publicationDate": "1943-05", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "American Journal of Epidemiology", "volume": "37", "issue": "3", "page": "273-288", "issn": "1476-6256, 0002-9262", "isbn": null, "authors": "THOMAS B. TURNER, ROBERT DYAR, E. GURNEY CLARK, MARY FOOTNER BIRKHEAD", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/oxfordjournals.aje.a118864", "pdfUrl": "http://academic.oup.com/aje/article-pdf/37/3/273/387689/37-3-273.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/nq/s6-xii.311.469g", "doi": "10.1093/nq/s6-xii.311.469g", "title": "Authors of quotations wanted", "publicationYear": 1885, "publicationDate": "1885-12-12", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Notes and Queries", "volume": "s6-XII", "issue": "311", "page": "469-469", "issn": "1471-6941, 0029-3970", "isbn": null, "authors": "H.", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/nq/s6-xii.311.469g", "pdfUrl": "http://academic.oup.com/nq/article-pdf/s6-XII/311/469/20783160/469-g.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
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{"paperId": "10.1093/intqhc/9.1.1", "doi": "10.1093/intqhc/9.1.1", "title": "COUNTERPOINT: Can CQI Really Work in Health Care? For How Long?", "publicationYear": 1997, "publicationDate": "1997", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "International Journal for Quality in Health Care", "volume": "9", "issue": "1", "page": "1-2", "issn": "1353-4505, 1464-3677", "isbn": null, "authors": "Z. STERN", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/intqhc/9.1.1", "pdfUrl": "http://academic.oup.com/intqhc/article-pdf/9/1/1/5051325/9-1-1.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/cdj/8.1.50", "doi": "10.1093/cdj/8.1.50", "title": "Book Reviews", "publicationYear": 1973, "publicationDate": "1973", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Community Development Journal", "volume": "8", "issue": "1", "page": "50-50", "issn": "0010-3802, 1468-2656", "isbn": null, "authors": "M. J. SHEPPERDSON", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/cdj/8.1.50", "pdfUrl": "http://academic.oup.com/cdj/article-pdf/8/1/50/958504/8-1-50a.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/jts/os-xxxiii.1.89", "doi": "10.1093/jts/os-xxxiii.1.89", "title": "REVIEWS", "publicationYear": 1931, "publicationDate": "1931", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "The Journal of Theological Studies", "volume": "os-XXXIII", "issue": "1", "page": "89-92", "issn": "0022-5185, 1477-4607", "isbn": null, "authors": "W.EMERY BARNES", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/jts/os-xxxiii.1.89", "pdfUrl": "http://academic.oup.com/jts/article-pdf/os-XXXIII/1/89/9860951/89.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/nq/s10-viii.184.10b", "doi": "10.1093/nq/s10-viii.184.10b", "title": "Sir George Monoux", "publicationYear": 1907, "publicationDate": "1907-07-06", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Notes and Queries", "volume": "s10-VIII", "issue": "184", "page": "10-10", "issn": "1471-6941, 0029-3970", "isbn": null, "authors": "M. L. R. Breslar", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/nq/s10-viii.184.10b", "pdfUrl": "http://academic.oup.com/nq/article-pdf/s10-VIII/184/10/20647847/10b.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/nq/s6-v.123.355b", "doi": "10.1093/nq/s6-v.123.355b", "title": "The British oak", "publicationYear": 1882, "publicationDate": "1882-05-06", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Notes and Queries", "volume": "s6-V", "issue": "123", "page": "355-355", "issn": "1471-6941, 0029-3970", "isbn": null, "authors": "E. H. M.", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/nq/s6-v.123.355b", "pdfUrl": "http://academic.oup.com/nq/article-pdf/s6-V/123/355/22691778/355-b.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/mind/xviii.1.636", "doi": "10.1093/mind/xviii.1.636", "title": "ARCHIV F. D. GESAMTE PSYCHOLOGIE", "publicationYear": 1909, "publicationDate": "1909", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Mind", "volume": "XVIII", "issue": "1", "page": "636-637", "issn": "0026-4423, 1460-2113", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/mind/xviii.1.636", "pdfUrl": "http://academic.oup.com/mind/article-pdf/XVIII/1/636/9889821/636.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/jac/40.3.345", "doi": "10.1093/jac/40.3.345", "title": "Enhancement of Burkholderia cepacia antimicrobial susceptibility by cationic compounds", "publicationYear": 1997, "publicationDate": "1997-09-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Journal of Antimicrobial Chemotherapy", "volume": "40", "issue": "3", "page": "345-351", "issn": "1460-2091", "isbn": null, "authors": "J. Rajyaguru", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 15, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/jac/40.3.345", "pdfUrl": "http://academic.oup.com/jac/article-pdf/40/3/345/9837780/400345.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.2307/4067484", "doi": "10.2307/4067484", "title": "Stejneger on a 'Lost Species' of Murrelet On Brachyramphus Perdix (Pall.) and Its Nearest Allies Leonhard Stejneger", "publicationYear": 1887, "publicationDate": "1887-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "The Auk", "volume": "4", "issue": "1", "page": "65-65", "issn": "0004-8038, 1938-4254", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/4067484", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/ajhp/48.10.2181", "doi": "10.1093/ajhp/48.10.2181", "title": "Visual compatibility of idarubicin hydrochloride with selected drugs during simulated Y-site injection", "publicationYear": 1991, "publicationDate": "1991-10-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "American Journal of Health-System Pharmacy", "volume": "48", "issue": "10", "page": "2181-2184", "issn": "1079-2082, 1535-2900", "isbn": null, "authors": "Robert C. Turowski, Jeffrey M. Durthaler", "authorCount": 2, "firstAuthorAffiliation": "The Ohio State University Hospitals, Columbus, OH", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/ajhp/48.10.2181", "pdfUrl": "http://academic.oup.com/ajhp/article-pdf/48/10/2181/28466457/ajhp2181.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/rpc/1996rpc45", "doi": "10.1093/rpc/1996rpc45", "title": "INTERNATIONAL TELESIS GROUP SERVICE MARK", "publicationYear": 1996, "publicationDate": "1996-01-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Reports of Patent, Design and Trade Mark Cases", "volume": "113", "issue": "2", "page": "45-72", "issn": "0080-1364, 1756-1000", "isbn": null, "authors": "Trade Marks Registry", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/rpc/1996rpc45", "pdfUrl": "http://academic.oup.com/rpc/article-pdf/113/2/45/6923767/1996rpc45.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/ecco-jcc/jju027.304", "doi": "10.1093/ecco-jcc/jju027.304", "title": "P187. Hearing loss in patients with Inflammatory Bowel Disease", "publicationYear": 2015, "publicationDate": "2015-02-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Journal of Crohn's and Colitis", "volume": "9", "issue": "suppl 1", "page": "S170-S170", "issn": "1873-9946, 1876-4479", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/ecco-jcc/jju027.304", "pdfUrl": "http://academic.oup.com/ecco-jcc/article-pdf/9/suppl_1/S170/1352303/jju027.304.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.2307/2216661", "doi": "10.2307/2216661", "title": "Descartes' Revision of the Cartesian Dualism", "publicationYear": 1957, "publicationDate": "1957-07", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "The Philosophical Quarterly", "volume": "7", "issue": "28", "page": "249", "issn": "0031-8094", "isbn": null, "authors": "Edward G. Ballard", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2216661", "pdfUrl": "http://academic.oup.com/pq/article-pdf/7/28/249/4384532/pq7-0249.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/mnras/202.1.53", "doi": "10.1093/mnras/202.1.53", "title": "Spectroscopic and photometric observations of six possible Seyfert galaxies", "publicationYear": 1983, "publicationDate": "1983-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Monthly Notices of the Royal Astronomical Society", "volume": "202", "issue": "1", "page": "53-57", "issn": "0035-8711, 1365-2966", "isbn": null, "authors": "T. D. Kinman", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 10, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/mnras/202.1.53", "pdfUrl": "http://academic.oup.com/mnras/article-pdf/202/1/53/18223710/mnras202-0053.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/sleep/zsac079.584", "doi": "10.1093/sleep/zsac079.584", "title": "0587 Sleep Problems are Associated with Treatment for Anemia in the US Population", "publicationYear": 2022, "publicationDate": "2022-05-25", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Sleep", "volume": "45", "issue": "Supplement_1", "page": "A258-A258", "issn": "0161-8105, 1550-9109", "isbn": null, "authors": "Sayani Shah, Brooke Mason, Chloe Wills, Andrew Tubbs, William Killgore, Michael Grandner", "authorCount": 6, "firstAuthorAffiliation": "University of Arizona", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/sleep/zsac079.584", "pdfUrl": "https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A258/43842806/zsac079.584.pdf", "abstract": "Abstract Introduction Anemia is characterized as low circulating hemoglobin and is often treated with an increase in iron consumption. Previous studies have linked anemia with Restless Legs Syndrome. Regarding other sleep disorders, Insomnia has been found to be associated with anemia in children, but the relationship has been understudied in adults. Methods A multinomial logistic regression was conducted on the data collected from 2017 to March 2020 for the National Health and Nutrition Examination Survey, to explore a relationship between those with self-assessed sleep problems and whether the participant was treated for anemia. Sleep problems were assessed using a item asking participants how often they have been bothered by difficulties “falling asleep, staying asleep, or sleeping too much,” categorized as “Never,” “Several Days,” “More Than Half the Days” and “Nearly Every Day” in the past 2 weeks. Anemia treatment was characterized as “yes” or “no” based on self-report, with any form of treatment in the past 3 months was considered as “yes.” Reported results were unweighted; weighted results forthcoming. Results Unadjusted results indicate that those being treated for anemia show an increased likelihood of sleep difficulties several days (OR:1.36, [1.07,1.73] p=0.011), more than half the days (OR: 1.59, [1.13,2.25] p=0.008), and nearly every day (OR: 1.85, [1.37,2.50] p&amp;lt;0.001), compared to those who report that they never have sleep difficulties. When adjusted for sex, age, race/ethnicity, education, and marital status, those being treated for anemia show significant increased odds of sleep problems several days (OR: 1.29, [1.01,1.65] p=0.041), more than half the days (OR: 1.50, [1.06,2.14] p=0.024), and nearly every day (OR: 1.55, [1.13,2.13] p=0.006), compared to never. Those being treated for anemia also had a higher likelihood of having short sleep (≤ 6 hours) during the week (OR: 1.56, [1.13,2.15], p=0.007) as well as long sleep( ≥ 9 hours) (OR: 1.75, [1.30,2.36], p&amp;lt;0.001) compared to those that slept a healthy amount, 6.5-8.5 hours a night. Conclusion There was a significant relationship between those treated for anemia the presence of sleep difficulties, as well as short and long sleep. Future studies should assess the associations between anemia and specific sleep characteristics, as sleep problems may be a cause, a consequence, or a marker of anemia. Also, the degree to which these sleep difficulties represent overlap with Restless Legs symptoms should be explored at the population level. Support (If Any)", "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/sleep/zsac079.356", "doi": "10.1093/sleep/zsac079.356", "title": "0359 Clinical Performance Quality of a Precision Oral Appliance Made from Novel Medical Grade Class VI Material", "publicationYear": 2022, "publicationDate": "2022-05-25", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Sleep", "volume": "45", "issue": "Supplement_1", "page": "A162-A162", "issn": "0161-8105, 1550-9109", "isbn": null, "authors": "Mark Murphy, Len Liptak, Sung Kim, Yoann Ojeda", "authorCount": 4, "firstAuthorAffiliation": "ProSomnus Sleep Technologies", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/sleep/zsac079.356", "pdfUrl": "https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A162/43842525/zsac079.356.pdf", "abstract": "Abstract Introduction Oral appliance therapy device quality is an important factor for successful, efficient treatment of Obstructive Sleep Apnea. Poor device quality, defined in this investigation as the remake rate, is costly. A previous investigation reports that 13% of oral appliance therapy devices required remakes, each costing an estimated $300 in lost productivity, fees for remakes, and three weeks of lost therapy. Other investigations associate poor quality with even higher costs and an increased propensity for the patient to discontinue treatment. Methods In this retrospective study design, quality data for 34,261 consecutively manufactured oral appliance therapy devices made from a novel medical grade class VI material was collected. Quality data was analyzed in total, and with 30-day and 60-day lag periods. The purpose of the lag periods was to account for the time between manufacture and delivery. Results Total remake rates were 1.2% (416/34,261). Total remake rates with a 30-day lag period were 1.3% (416/30,946). Total remakes with a 60-day lag period were 1.5% (416/26,964). Conclusion The clinical performance quality for a new precision oral appliance made from a novel medical grade class VI material is encouraging. Remake rates were between 1.2% and 1.5% depending on the lag period, which is directionally favorable in comparison with previously reported remake data. Support (If Any) Data provided by ProSomnus Sleep Technologies.", "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/sleep/zsac079.631", "doi": "10.1093/sleep/zsac079.631", "title": "0634 Symptoms of insomnia and depression among individuals with Multiple Sclerosis before and during the COVID-19 – results from a prospective longitudinal study", "publicationYear": 2022, "publicationDate": "2022-05-25", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Sleep", "volume": "45", "issue": "Supplement_1", "page": "A278-A279", "issn": "0161-8105, 1550-9109", "isbn": null, "authors": "Dena Sadeghi-Bahmani, Youkhabeh Mohammadian, Nahid Piri, Laleh Sadeghi Bahmani, Serge Brand, Andrea Goldstein-Piekarski, Habibollah Khazaie, James Gross", "authorCount": 8, "firstAuthorAffiliation": "Department of Psychology, Stanford University", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/sleep/zsac079.631", "pdfUrl": "https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A278/43843549/zsac079.631.pdf", "abstract": "Abstract Introduction There is some -- but inconsistent -- evidence that sleep and psychological health have deteriorated in the general population as a result of the COVID-19-pandemic and its related social restrictions. In the present study, we investigated whether and to what extent symptoms of insomnia, depression, fatigue, and paresthesia changed from before to during the COVID-19-pandemic among women diagnosed with multiple sclerosis (MS). Methods A total of 90 women with MS (mean age; 37.62 (SD = 8.61) years; EDSS score: median: 2.5 (range: 0-6.50)) completed a series of self-rating scales at two time-points: Nine months before the COVID-19-outbreak in May 2019 (baseline) and during the COVID-19-pandemic (study end; 12 months after baseline: May 2020). Self-rating questionnaires covered sociodemographic and disease-related information, symptoms of insomnia, depression, fatigue, and paresthesia. Results Symptoms of depression increased over time (medium effect size: Cohen’s d = 0.53), while symptoms of insomnia (small effect size: Cohen’s d = 0.43), fatigue (trivial effect size: Cohen’s d = 0.19), and paresthesia (trivial effect size: Cohen’s d = 0.08) did not. The only predictor for insomnia during the COVID-19-pandemic was insomnia before the COVID-19-pandemic (β = 0.36; p = 0.001); the only predictor for depression during the COVID-19-pandemic was insomnia before the COVID-19-pandemic (β = 0.66; p = 0.001). Conclusion Overall, among a sample of female individuals with MS the COVID-19-pandemic and its related social restrictions may have had a modest influence on participants’ core concerns of insomnia, depression, fatigue, and paresthesia. Support (If Any)", "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1093/sleep/zsac079.560", "doi": "10.1093/sleep/zsac079.560", "title": "0563 Association between actigraphic sleep measures and lymphocyte subsets in people with chronic HIV infection", "publicationYear": 2022, "publicationDate": "2022-05-25", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Sleep", "volume": "45", "issue": "Supplement_1", "page": "A248-A248", "issn": "0161-8105, 1550-9109", "isbn": null, "authors": "Malvika Sharma, Priya Borker, Bernard Macatangay, Naresh Punjabi, Charles Rinaldo, Steven Wolinsky, Joshua Hyong-Jin Cho, Heather McKay, Sanjay Patel", "authorCount": 9, "firstAuthorAffiliation": "University of Pittsburgh Medical Center", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/sleep/zsac079.560", "pdfUrl": "https://academic.oup.com/sleep/article-pdf/45/Supplement_1/A248/43842994/zsac079.560.pdf", "abstract": "Abstract Introduction While inadequate sleep is known to increase inflammation in immunocompetent individuals, it is unknown if poor sleep worsens inflammation in people living with HIV. The ratio of CD4+/CD8+ T cells is a readily derived measure of chronic inflammation in people living with HIV. We sought to investigate the association between lymphocyte subsets and actigraphy-derived sleep measures in a cohort of HIV seropositive men. Methods HIV seropositive men on antiretroviral therapy for &amp;gt; 1 year and with undetectable (&amp;lt; 20 copies/mL) plasma HIV-1 RNA participating in the Multicenter AIDS Cohort Study underwent a sleep evaluation with 1 week of wrist actigraphy. Data from 287 participants with ≥ 5 days of actigraphy were analyzed. We evaluated three dimensions of sleep: mean nocturnal sleep duration, sleep onset latency, and sleep maintenance efficiency. Linear regression was used to assess the association between each sleep dimension with CD4+ and CD8+ T-cell counts. Because of a U-shaped association, nocturnal sleep duration was also modelled dichotomously as a normal (6-8 hrs) vs. abnormal duration (&amp;lt;6 or &amp;gt;8 hrs). Results Participants had a mean (±SD) age of 55 ± 12 years, mean CD4+ count of 723 ± 293 cells/ml, and 7.0 ± 1.7 days of actigraphy data. None of the sleep measures were associated with CD4+ counts. However, participants with abnormal sleep duration had 129 ± 31 cells/mL higher CD8+ counts compared to those with normal sleep duration (p=0.01). There were also nonsignificant trends whereby every 30-minute increase in sleep latency was associated with a 138 cells/ml increase in CD8+ count (p=0.07) while every 10% reduction in sleep efficiency was associated with a 56 cells/ml increase in CD8+ count (p=0.12). These findings were unchanged after adjusting for age and body mass index. Conclusion Among men with treated HIV infection, abnormal sleep duration (both short and long) is associated with increased circulating CD8+ T cell count, suggesting increased chronic inflammation. Support (If Any) NIH AI0355041, HL082610 and American Thoracic Society ASPIRE Fellowship", "subject": null, "language": "en", "_run_id": "D8FFphHHA6QRIqEaa", "_dataset_id": "VEcVqPhQc82PmIivF"}
{"paperId": "10.1021/bp990294w", "doi": "10.1021/bp990294w", "title": "Biotechnology Notables", "publicationYear": 2000, "publicationDate": "2000-01", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "16", "issue": "4", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/bp990294w", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420010403", "doi": "10.1002/btpr.5420010403", "title": "Biotechnology Shorts", "publicationYear": 1985, "publicationDate": "1985-12", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "1", "issue": "4", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420010403", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420030312", "doi": "10.1002/btpr.5420030312", "title": "Biotechnology Shorts", "publicationYear": 1987, "publicationDate": "1987-09", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "3", "issue": "3", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420030312", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/(issn)1860-7314", "doi": "10.1002/(issn)1860-7314", "title": "Biotechnology Journal", "publicationYear": 2006, "publicationDate": "2006-03-14", "type": "journal", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": "1860-6768", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 24, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/(issn)1860-7314", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420010303", "doi": "10.1002/btpr.5420010303", "title": "Biotechnology Shorts", "publicationYear": 1985, "publicationDate": "1985-09", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "1", "issue": "3", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420010303", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201290006", "doi": "10.1002/biot.201290006", "title": "Industrial Biotechnology", "publicationYear": 2012, "publicationDate": "2012-02", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "7", "issue": "2", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201290006", "pdfUrl": null, "abstract": "AbstractCover illustrationIndustrial biotechnology. Renewable biomass can be used as a raw material for the production of various chemicals, fuels and materials in a cost‐effective manner by employing metabolically engineered high performance microorganisms. This cover art shows production of biobutanol from renewable biomass by employing engineered clostridia (see the article by Jang et al. http://dx.doi.org/10.1002/biot.201100059). The cover picture was created by Prof. Sang Yup Lee and Dr. Yu Sin Jang at KAIST, Korea.", "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201490015", "doi": "10.1002/biot.201490015", "title": "Contents: Biotechnology Journal 5/2014", "publicationYear": 2014, "publicationDate": "2014-05", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "9", "issue": "5", "page": "589-590", "issn": "1860-6768", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201490015", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201300056", "doi": "10.1002/biot.201300056", "title": "Editorial: Biotechnology Journal's diverse coverage of biotechnology", "publicationYear": 2014, "publicationDate": "2014-03", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "9", "issue": "3", "page": "311-312", "issn": "1860-6768, 1860-7314", "isbn": null, "authors": "Michael Wink", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 14, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201300056", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420020403", "doi": "10.1002/btpr.5420020403", "title": "Biotechnology Shorts", "publicationYear": 1986, "publicationDate": "1986-12", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "2", "issue": "4", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420020403", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420020103", "doi": "10.1002/btpr.5420020103", "title": "Biotechnology Shorts", "publicationYear": 1986, "publicationDate": "1986-03", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "2", "issue": "1", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420020103", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420030403", "doi": "10.1002/btpr.5420030403", "title": "Biotechnology Shorts", "publicationYear": 1987, "publicationDate": "1987-12", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "3", "issue": "4", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420030403", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420050402", "doi": "10.1002/btpr.5420050402", "title": "Biotechnology Shorts", "publicationYear": 1989, "publicationDate": "1989-12", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "5", "issue": "4", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420050402", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420030112", "doi": "10.1002/btpr.5420030112", "title": "Biotechnology Shorts", "publicationYear": 1987, "publicationDate": "1987-03", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "3", "issue": "1", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420030112", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420050204", "doi": "10.1002/btpr.5420050204", "title": "Biotechnology Shorts", "publicationYear": 1989, "publicationDate": "1989-06", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "5", "issue": "2", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420050204", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420010203", "doi": "10.1002/btpr.5420010203", "title": "Biotechnology Shorts", "publicationYear": 1985, "publicationDate": "1985-06", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "1", "issue": "2", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420010203", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420010103", "doi": "10.1002/btpr.5420010103", "title": "Biotechnology Shorts", "publicationYear": 1985, "publicationDate": "1985-03", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "1", "issue": "1", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420010103", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420020203", "doi": "10.1002/btpr.5420020203", "title": "Biotechnology Shorts", "publicationYear": 1986, "publicationDate": "1986-06", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "2", "issue": "2", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420020203", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420050103", "doi": "10.1002/btpr.5420050103", "title": "Biotechnology Shorts", "publicationYear": 1989, "publicationDate": "1989-03", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "5", "issue": "1", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420050103", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201390032", "doi": "10.1002/biot.201390032", "title": "International Biotechnology", "publicationYear": 2013, "publicationDate": "2013-07", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "8", "issue": "7", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201390032", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.201390032", "abstract": "AbstractCover illustrationSpecial Issue: International Biotechnology. Efforts to develop biotechnological strategies for various applications have reached a global scale as indicated by the diverse international representation at the IBS2012 organized by the Asian Federation of Biotechnology (AFOB). For this special issue's cover, one such useful technique – the rapid gene knockout method – is schematically shown: a series of outer grey arrows represent the multiple steps required for conventional gene knockout experiments, while the inner green arrow represents the rapid gene knockout method; the steam‐engine and the bullet train are used to further illustrate the difference. Image provided by Sang Yup Lee and Chan Woo Song (KAIST, Korea).", "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420020304", "doi": "10.1002/btpr.5420020304", "title": "Biotechnology Shorts", "publicationYear": 1986, "publicationDate": "1986-09", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "2", "issue": "3", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420020304", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201390048", "doi": "10.1002/biot.201390048", "title": "Plant Biotechnology", "publicationYear": 2013, "publicationDate": "2013-10", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "8", "issue": "10", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201390048", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.201390048", "abstract": "AbstractCover illustrationThis Special Issue of Biotechnology Journal is edited by Prof. Eva Stöger and covers the latest breakthroughs in plant biotechnology. The cover image shows genetically modified corn producing an anti‐HIV antibody along with DsRed as a visual marker. Image courtesy of Dr. Thomas Rademacher (RWTH and Fraunhofer IME, Aachen, Germany). Border around image: © boulemon – Fotolia.com.", "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/btpr.5420050303", "doi": "10.1002/btpr.5420050303", "title": "Biotechnology Shorts", "publicationYear": 1989, "publicationDate": "1989-09", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Progress", "volume": "5", "issue": "3", "page": null, "issn": "8756-7938, 1520-6033", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/btpr.5420050303", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201390053", "doi": "10.1002/biot.201390053", "title": "Asian Federation of Biotechnology (AFOB)", "publicationYear": 2013, "publicationDate": "2013-11", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "8", "issue": "11", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201390053", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.201390053", "abstract": "AbstractCover illustration: This issue is the first official special issue of Biotechnology Journal with the Asian Federation of Biotechnology (AFOB). In the cover, we use the grain as a symbol and analogy for biotechnology, as both the grain and biotechnology are common and uniting factors that link the member countries of the AFOB. Gran image credit: © Myimagine– Fotolia.com.", "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201190056", "doi": "10.1002/biot.201190056", "title": "Biotechnology in Asia", "publicationYear": 2011, "publicationDate": "2011-11", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "6", "issue": "11", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201190056", "pdfUrl": null, "abstract": "AbstractCover illustration:The Asian Federation of Biotechnology (AFOB, http://www.afob.org) was established to promote cooperation between all those interested in biotechnology in Asia and stimulate innovation and technology transfer with the goal of advancing biotechnology in Asia and the rest of the world. BTJ continues its cooperation with AFOB and Asian Congress on Biotechnology (ACB‐2011), with a special issue of articles from selected invited speakers at the congress, edited by Jian‐Jiang Zhong (Chair ACB‐2011 Organizing Committee; SJTU, China), and Sang Yup Lee (BTJ's Editor‐in‐Chief; KAIST, Korea). Read the Editorial: http://dx.doi.org/10.1002/201100445", "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201870092", "doi": "10.1002/biot.201870092", "title": "Editorial Board: Biotechnology Journal 9/2018", "publicationYear": 2018, "publicationDate": "2018-09", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "13", "issue": "9", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201870092", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.201870092", "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.200990104", "doi": "10.1002/biot.200990104", "title": "Editorial Board: Biotechnology Journal 12/2009", "publicationYear": 2009, "publicationDate": "2009-12", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "4", "issue": "12", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.200990104", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.202370102", "doi": "10.1002/biot.202370102", "title": "Editorial Board: Biotechnology Journal 10/2023", "publicationYear": 2023, "publicationDate": "2023-10", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "18", "issue": "10", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.202370102", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.202070092", "doi": "10.1002/biot.202070092", "title": "Editorial Board: Biotechnology Journal 9/2020", "publicationYear": 2020, "publicationDate": "2020-09", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "15", "issue": "9", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.202070092", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/biot.202070092", "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.200890023", "doi": "10.1002/biot.200890023", "title": "Biotechnology Journal 3/2008", "publicationYear": 2008, "publicationDate": "2008-03", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "3", "issue": "3", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.200890023", "pdfUrl": null, "abstract": "AbstractCover illustration: Spectral karyotype of chromosomes. The BTJ special issue on Methods and Advances in Biotech is not only covering DNA‐based methods but also exciting highlights in the fields of imaging, bioluminescent screening methods, plant transformation assays, stem cell differentiation on chips and much more. Image copyright USA Federal Government. http://www.genome.gov, http://doi.wiley.com/biot.200800042", "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201590005", "doi": "10.1002/biot.201590005", "title": "Cover Picture: Biotechnology Journal 03/2015", "publicationYear": 2015, "publicationDate": "2015-03", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "10", "issue": "3", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201590005", "pdfUrl": null, "abstract": "AbstractSpecial issue: Protein Stabilization. This Special issue edited by Marina Lotti and Francesco Secundo includes contributions on protein stability concerning protein production and purification, screening for more stable proteins and the impact of protein aggregation. The articles were presented at the 10th International Conference on Protein Stabilisation (7–9 May 2014) in Stresa (Lake Maggiore, Italy). The cover illustrates the difficult balance between stability and other properties of the proteins. Image: © styf Fotolia.com", "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201770082", "doi": "10.1002/biot.201770082", "title": "Editorial Board: Biotechnology Journal 8/2017", "publicationYear": 2017, "publicationDate": "2017-08", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "12", "issue": "8", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201770082", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.201770082", "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201970062", "doi": "10.1002/biot.201970062", "title": "Editorial Board: Biotechnology Journal 6/2019", "publicationYear": 2019, "publicationDate": "2019-06", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "14", "issue": "6", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201970062", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.201970062", "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.202270092", "doi": "10.1002/biot.202270092", "title": "Editorial Board: Biotechnology Journal 9/2022", "publicationYear": 2022, "publicationDate": "2022-09", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "17", "issue": "9", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.202270092", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/biot.202270092", "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201970041", "doi": "10.1002/biot.201970041", "title": "Cover Picture: Biotechnology Journal 4/2019", "publicationYear": 2019, "publicationDate": "2019-04", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "14", "issue": "4", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201970041", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.201970041", "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201770042", "doi": "10.1002/biot.201770042", "title": "Editorial Board: Biotechnology Journal 4/2017", "publicationYear": 2017, "publicationDate": "2017-04", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "12", "issue": "4", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201770042", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.201770042", "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.70254", "doi": "10.1002/biot.70254", "title": "Issue Information: Biotechnology Journal 6/2026", "publicationYear": 2026, "publicationDate": "2026-06", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "21", "issue": "6", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.70254", "pdfUrl": "https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/biot.70254", "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201490040", "doi": "10.1002/biot.201490040", "title": "Biotechnology Journal 2014 Cover Gallery", "publicationYear": 2014, "publicationDate": "2014-12", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "9", "issue": "12", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201490040", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201390062", "doi": "10.1002/biot.201390062", "title": "Biotechnology Journal 2013 Cover Gallery", "publicationYear": 2013, "publicationDate": "2013-12", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "8", "issue": "12", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201390062", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.70137", "doi": "10.1002/biot.70137", "title": "Issue Information: Biotechnology Journal 10/2025", "publicationYear": 2025, "publicationDate": "2025-10", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "20", "issue": "10", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.70137", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201490007", "doi": "10.1002/biot.201490007", "title": "Cover Picture: Biotechnology Journal 3/2014", "publicationYear": 2014, "publicationDate": "2014-03", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "9", "issue": "3", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201490007", "pdfUrl": null, "abstract": "AbstractThis “regular” issue of Biotechnology Journal gathers the state‐of‐the‐art in biotechnology, including articles on CHO cells, plant biotechnology and tissue engineering. The cover image shows immunohistochemical staining of tissue sections using antibodies recognizing different target proteins (www.proteinatlas.org) and is provided by Sophia Hober et al., authors of “Antibody performance in western blot applications is context‐dependent” (http://dx.doi.org/10.1002/biot.201300341)", "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.202270052", "doi": "10.1002/biot.202270052", "title": "Editorial Board: Biotechnology Journal 5/2022", "publicationYear": 2022, "publicationDate": "2022-05", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "17", "issue": "5", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.202270052", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/biot.202270052", "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
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{"paperId": "10.1002/biot.202070052", "doi": "10.1002/biot.202070052", "title": "Editorial Board: Biotechnology Journal 5/2020", "publicationYear": 2020, "publicationDate": "2020-05", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "15", "issue": "5", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.202070052", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.202070052", "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.202470091", "doi": "10.1002/biot.202470091", "title": "Issue Information: Biotechnology Journal 9/2024", "publicationYear": 2024, "publicationDate": "2024-09", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "19", "issue": "9", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.202470091", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201590016", "doi": "10.1002/biot.201590016", "title": "Cover Picture: Biotechnology Journal 7/2015", "publicationYear": 2015, "publicationDate": "2015-07", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "10", "issue": "7", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201590016", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.201590016", "abstract": "AbstractSpecial issue: Mammalian Production Systems. This special issue is edited by Nicole Borth and Lars Nielsen. It focuses on the use of CHO cells and their improvement to produce recombinant proteins. The articles cover the application of CRISPR technology, systems biology and modeling approaches as well as bioinformatics methods. The cover visualizes the highly interconnected metabolic pathway map of CHO cells based on a genome‐scale metabolic reconstruction (blue: reactions, red: molecular species). Image by Michael Hanscho.", "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201490013", "doi": "10.1002/biot.201490013", "title": "Editorial Board: Biotechnology Journal 4/2014", "publicationYear": 2014, "publicationDate": "2014-04", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "9", "issue": "4", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201490013", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201590024", "doi": "10.1002/biot.201590024", "title": "Cover Picture: Biotechnology Journal 11/2015", "publicationYear": 2015, "publicationDate": "2015-09", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "10", "issue": "11", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201590024", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.201590024", "abstract": "AbstractThis regular issue of BTJ features articles on the production of biofuels, small molecules and recombinant proteins. The cover is inspired by an article describing increased expression levels of recombinant proteins in potato tubers upon post‐harvest light treatment. © Lenslife – Fotolia.com", "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201770111", "doi": "10.1002/biot.201770111", "title": "Cover Picture: Biotechnology Journal 11/2017", "publicationYear": 2017, "publicationDate": "2017-11", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "12", "issue": "11", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201770111", "pdfUrl": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.201770111", "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201290049", "doi": "10.1002/biot.201290049", "title": "Editorial Board: Biotechnology Journal 9/2012", "publicationYear": 2012, "publicationDate": "2012-09", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "7", "issue": "9", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201290049", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1002/biot.201670021", "doi": "10.1002/biot.201670021", "title": "Cover Picture: Biotechnology Journal 2/2016", "publicationYear": 2016, "publicationDate": "2016-02", "type": "journal-article", "publisher": "Wiley", "containerTitle": "Biotechnology Journal", "volume": "11", "issue": "2", "page": null, "issn": "1860-6768, 1860-7314", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/biot.201670021", "pdfUrl": null, "abstract": "AbstractFocus: Synthetic biology. This Focus issue is edited by George Chen and Michael Jewett features articles from the Cold Spring Harbor Asia Synthetic Biology Meeting in Suzhou, China. It includes articles on cell‐free protein synthesis, genome mining, and a method for a rapid production of protein biologics. The cover shows the development of a high‐yielding bacterial cell‐free protein synthesis for the production of active proteins containing copper cofactors. It specifically demonstrates a simple method for producing multicoppper oxidases (MCOs). By decoupling catalyst synthesis from catalyst utilization, advantages are gained for synthesizing hard to express proteins. Image by Jessica Stark, Tom Lawton, and Michael Jewett.", "subject": null, "language": "en", "_run_id": "kv2CPwj0zrmr1Z4kl", "_dataset_id": "Iig3vpOj4IXMeavMf"}
{"paperId": "10.1007/978-94-007-6519-1_1125", "doi": "10.1007/978-94-007-6519-1_1125", "title": "Intentionalism", "publicationYear": 2023, "publicationDate": "2023", "type": "book-chapter", "publisher": "Springer Netherlands", "containerTitle": "Encyclopedia of the Philosophy of Law and Social Philosophy", "volume": null, "issue": null, "page": "1485-1491", "issn": null, "isbn": "9789400765184, 9789400765191", "authors": "Maija Aalto-Heinilä", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-94-007-6519-1_1125", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "u3QC1sAthqQsh935R", "_dataset_id": "bh0SjD69v7PupAuEH"}
{"paperId": "10.1007/978-94-024-2158-3_13", "doi": "10.1007/978-94-024-2158-3_13", "title": "Group Representations", "publicationYear": 2023, "publicationDate": "2023", "type": "book-chapter", "publisher": "Springer Netherlands", "containerTitle": "Crystallographic Texture and Group Representations", "volume": null, "issue": null, "page": "287-312", "issn": null, "isbn": "9789402421576, 9789402421583", "authors": "Chi-Sing Man", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-94-024-2158-3_13", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "u3QC1sAthqQsh935R", "_dataset_id": "bh0SjD69v7PupAuEH"}
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{"paperId": "10.1007/978-94-007-6519-1_752", "doi": "10.1007/978-94-007-6519-1_752", "title": "Burlamaqui, Jean-Jacques", "publicationYear": 2023, "publicationDate": "2023", "type": "book-chapter", "publisher": "Springer Netherlands", "containerTitle": "Encyclopedia of the Philosophy of Law and Social Philosophy", "volume": null, "issue": null, "page": "353-356", "issn": null, "isbn": "9789400765184, 9789400765191", "authors": "Meri Päivärinne", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 4, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-94-007-6519-1_752", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "u3QC1sAthqQsh935R", "_dataset_id": "bh0SjD69v7PupAuEH"}
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{"paperId": "10.36227/techrxiv.175393457.79277555/v1", "doi": "10.36227/techrxiv.175393457.79277555/v1", "title": "Exploring Scientific Principles and Laws of Artificial Intelligence, World Model, and Artificial General Intelligence (AGI) in Future Intelligence Networking: Paradigms, Architectures, and Innovations", "publicationYear": 2025, "publicationDate": "2025-07-31", "type": "posted-content", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Dajun Zhang, Wei Shi, Xiaowei Jia", "authorCount": 3, "firstAuthorAffiliation": "School of Information Technology, Carleton University", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.36227/techrxiv.175393457.79277555/v1", "pdfUrl": null, "abstract": "Intelligence Networking (IN) is an emerging paradigm that seeks to embed intelligence into every layer of the network, enabling intelligent decision-making and service delivery to be as seamless and efficient as accessing conventional information. This survey offers a comprehensive overview of IN, focusing on its evolution, foundational technologies, architectural frameworks, core applications, and theoretical underpinnings of intelligence. It aims to serve as a valuable reference for researchers exploring the principles, structures, and mathematical modeling of IN. We begin by tracing the evolution of networking paradigms to highlight the growing interdependence between networking and intelligence, establishing the basic logic for IN's emergence. We then introduce a layered IN architecture and examine enabling technologies and applications across each layer. In addition, we explore the definition of intelligence within the context of networking, discuss relevant world models, analyze first principles derived from this definition, and explore the intrinsic connections between network intelligence and Artificial General Intelligence (AGI). The survey concludes with a discussion of future research directions and potential technological breakthroughs needed to realize the full promise of IN.", "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
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{"paperId": "10.1109/tai.2025.3569136", "doi": "10.1109/tai.2025.3569136", "title": "IEEE Transactions on Artificial Intelligence Publication Information", "publicationYear": 2025, "publicationDate": "2025-06", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Artificial Intelligence", "volume": "6", "issue": "6", "page": "C2-C2", "issn": "2691-4581", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tai.2025.3569136", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
{"paperId": "10.1109/tai.2023.3311531", "doi": "10.1109/tai.2023.3311531", "title": "IEEE Transactions on Artificial Intelligence Publication Information", "publicationYear": 2023, "publicationDate": "2023-10", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Artificial Intelligence", "volume": "4", "issue": "5", "page": "C2-C2", "issn": "2691-4581", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tai.2023.3311531", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
{"paperId": "10.1109/tai.2024.3470571", "doi": "10.1109/tai.2024.3470571", "title": "IEEE Transactions on Artificial Intelligence Publication Information", "publicationYear": 2024, "publicationDate": "2024-10", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Artificial Intelligence", "volume": "5", "issue": "10", "page": "C2-C2", "issn": "2691-4581", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tai.2024.3470571", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
{"paperId": "10.1109/tai.2022.3142488", "doi": "10.1109/tai.2022.3142488", "title": "IEEE Transactions on Artificial Intelligence [Front cover]", "publicationYear": 2022, "publicationDate": "2022-02", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Artificial Intelligence", "volume": "3", "issue": "1", "page": "C1-C1", "issn": "2691-4581", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tai.2022.3142488", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
{"paperId": "10.1109/tai.2026.3702182", "doi": "10.1109/tai.2026.3702182", "title": "IEEE Transactions on Artificial Intelligence Publication Information", "publicationYear": 2026, "publicationDate": "2026-07", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Artificial Intelligence", "volume": "7", "issue": "7", "page": "C2-C2", "issn": "2691-4581", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tai.2026.3702182", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
{"paperId": "10.1109/tai.2024.3439048", "doi": "10.1109/tai.2024.3439048", "title": "Editorial: From Explainable Artificial Intelligence (xAI) to Understandable Artificial Intelligence (uAI)", "publicationYear": 2024, "publicationDate": "2024-09", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Artificial Intelligence", "volume": "5", "issue": "9", "page": "4310-4314", "issn": "2691-4581", "isbn": null, "authors": "Hussein Abbass, Keeley Crockett, Jonathan Garibaldi, Alexander Gegov, Uzay Kaymak, Joao Miguel C. Sousa", "authorCount": 6, "firstAuthorAffiliation": "School of Systems and Computing, University of New South Wales, Canberra, ACT, Australia", "isReferencedByCount": 11, "referenceCount": 2, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tai.2024.3439048", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
{"paperId": "10.1109/tai.2020.3035827", "doi": "10.1109/tai.2020.3035827", "title": "Editorial: Artificial Intelligence: A New Transactions", "publicationYear": 2020, "publicationDate": "2020-08", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Artificial Intelligence", "volume": "1", "issue": "1", "page": "2-4", "issn": "2691-4581", "isbn": null, "authors": "Hussein Abbass", "authorCount": 1, "firstAuthorAffiliation": "University of New South Wales, Canberra, ACT, Australia", "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tai.2020.3035827", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
{"paperId": "10.1109/tai.2022.3221508", "doi": "10.1109/tai.2022.3221508", "title": "IEEE Transactions on Artificial Intelligence Publication Information", "publicationYear": 2022, "publicationDate": "2022-12", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Artificial Intelligence", "volume": "3", "issue": "6", "page": "C2-C2", "issn": "2691-4581", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tai.2022.3221508", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
{"paperId": "10.1109/tai.2025.3632311", "doi": "10.1109/tai.2025.3632311", "title": "IEEE Transactions on Artificial Intelligence Publication Information", "publicationYear": 2025, "publicationDate": "2025-12", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Artificial Intelligence", "volume": "6", "issue": "12", "page": "C2-C2", "issn": "2691-4581", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tai.2025.3632311", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
{"paperId": "10.36227/techrxiv.175393457.79277555/v2", "doi": "10.36227/techrxiv.175393457.79277555/v2", "title": "Exploring Scientific Principles and Laws of Artificial Intelligence, World Model, and Artificial General Intelligence (AGI) in Future Intelligence Networking: Paradigms, Architectures, and Innovations", "publicationYear": 2026, "publicationDate": "2026-02-03", "type": "posted-content", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Dajun Zhang, Wei Shi, Xiaowei Jia", "authorCount": 3, "firstAuthorAffiliation": "School of Information Technology, Carleton University", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.36227/techrxiv.175393457.79277555/v2", "pdfUrl": null, "abstract": "Intelligence Networking (IN) is an emerging paradigm that seeks to embed intelligence into every layer of the network, enabling intelligent decision-making and service delivery to be as seamless and efficient as accessing conventional information. This survey offers a comprehensive overview of IN, focusing on its evolution, foundational technologies, architectural frameworks, core applications, and theoretical underpinnings of intelligence. It aims to serve as a valuable reference for researchers exploring the principles, structures, and mathematical modeling of IN. We begin by tracing the evolution of networking paradigms to highlight the growing interdependence between networking and intelligence, establishing the basic logic for IN’s emergence. We then introduce a layered IN architecture and analyze enabling technologies and applications across each layer. In addition, we explore the definition of intelligence within the context of networking, discuss relevant world models, analyze first principles derived from this definition, and explore the intrinsic connections between network intelligence and Artificial General Intelligence (AGI). The survey concludes with a discussion of future research directions.", "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
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{"paperId": "10.1109/tai.2024.3372794", "doi": "10.1109/tai.2024.3372794", "title": "IEEE Transactions on Artificial Intelligence Publication Information", "publicationYear": 2024, "publicationDate": "2024-03", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Artificial Intelligence", "volume": "5", "issue": "3", "page": "C2-C2", "issn": "2691-4581", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tai.2024.3372794", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
{"paperId": "10.1109/tai.2023.3255022", "doi": "10.1109/tai.2023.3255022", "title": "IEEE Transactions on Artificial Intelligence Publication Information", "publicationYear": 2023, "publicationDate": "2023-04", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Transactions on Artificial Intelligence", "volume": "4", "issue": "2", "page": "C2-C2", "issn": "2691-4581", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/tai.2023.3255022", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "ncQQWuTVMRsTXbaMR", "_dataset_id": "U2RFX67LbIj4gxhYx"}
{"paperId": "10.2307/1317044", "doi": "10.2307/1317044", "title": "\"Teaching Sociology\" on Teaching Sociology", "publicationYear": 1980, "publicationDate": "1980-10", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "8", "issue": "1", "page": "3", "issn": "0092-055X", "isbn": null, "authors": "Richard J. Gelles", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1317044", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/002071526500600207", "doi": "10.1177/002071526500600207", "title": "The Sociology of Sociology", "publicationYear": 1965, "publicationDate": "1965-09-01", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "International Journal of Comparative Sociology", "volume": "6", "issue": "2", "page": "278-284", "issn": "0020-7152", "isbn": null, "authors": "K. Ishwaran", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/002071526500600207", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/1316957", "doi": "10.2307/1316957", "title": "Sociology versus Religion?: The Case of the 1973 Introductory Sociology Texts", "publicationYear": 1977, "publicationDate": "1977-07", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "4", "issue": "4", "page": "357", "issn": "0092-055X", "isbn": null, "authors": "James R. Kelly", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1316957", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/1318888", "doi": "10.2307/1318888", "title": "Enduring Issues in Sociology: Opposing Viewpoints for Teaching Sociology", "publicationYear": 1996, "publicationDate": "1996-10", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "24", "issue": "4", "page": "410", "issn": "0092-055X", "isbn": null, "authors": "Sylvia Hale, L. Barteck, K. Mullin", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1318888", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/0038038516646284", "doi": "10.1177/0038038516646284", "title": "John Holmwood: Sociology of Structure, Sociology as Structure", "publicationYear": 2016, "publicationDate": "2016-10", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "50", "issue": "5", "page": "1002-1011", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "Nasar Meer, John Holmwood", "authorCount": 2, "firstAuthorAffiliation": "University of Strathclyde, UK", "isReferencedByCount": 2, "referenceCount": 4, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/0038038516646284", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/0038038516646284", "abstract": null, "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/003803857400800144", "doi": "10.1177/003803857400800144", "title": "The Phenomenon of Sociology: A Reader in the Sociology of Sociology", "publicationYear": 1974, "publicationDate": "1974-01", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "8", "issue": "1", "page": "189-190", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "Jennifer Platt", "authorCount": 1, "firstAuthorAffiliation": "University of Sussex", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/003803857400800144", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/003803857400800144", "abstract": null, "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/s0038038500000353", "doi": "10.1177/s0038038500000353", "title": "Social Epistemology: A Philosophy for Sociology or a Sociology of Philosophy?", "publicationYear": 2000, "publicationDate": "2000-08", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "34", "issue": "3", "page": "573-578", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "Steve Fuller", "authorCount": 1, "firstAuthorAffiliation": "Department of Sociology University of Warwick", "isReferencedByCount": 5, "referenceCount": 5, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/s0038038500000353", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/S0038038500000353", "abstract": null, "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/003803857500900207", "doi": "10.1177/003803857500900207", "title": "Ambivalent Sociology", "publicationYear": 1975, "publicationDate": "1975-05", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "9", "issue": "2", "page": "317-321", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "David Lazar", "authorCount": 1, "firstAuthorAffiliation": "University of Aberdeen", "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/003803857500900207", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/003803857500900207", "abstract": null, "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/2063544", "doi": "10.2307/2063544", "title": "Sociology.", "publicationYear": 1972, "publicationDate": "1972-07", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "1", "issue": "4", "page": "371", "issn": "0094-3061", "isbn": null, "authors": "Paul Sites, David Popenoe", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2063544", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/003803857200600232", "doi": "10.1177/003803857200600232", "title": "The Sociology of Sociology", "publicationYear": 1972, "publicationDate": "1972-05", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "6", "issue": "2", "page": "313-314", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "Jennifer Platt", "authorCount": 1, "firstAuthorAffiliation": "University of Sussex", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/003803857200600232", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/003803857200600232", "abstract": null, "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/2654757", "doi": "10.2307/2654757", "title": "Sociology after Postmodernism", "publicationYear": 1998, "publicationDate": "1998-01", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "27", "issue": "1", "page": "106", "issn": "0094-3061", "isbn": null, "authors": "Ben Agger, David Owen", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2654757", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/1317185", "doi": "10.2307/1317185", "title": "Errata: Introductory Sociology: A Behavioral Objectives Approach", "publicationYear": 1976, "publicationDate": "1976-01", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "3", "issue": "2", "page": "197", "issn": "0092-055X", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1317185", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/003803857100500236", "doi": "10.1177/003803857100500236", "title": "Rural Sociology", "publicationYear": 1971, "publicationDate": "1971-05", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "5", "issue": "2", "page": "280-281", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "Richard Scase", "authorCount": 1, "firstAuthorAffiliation": "University of Kent at Canterbury", "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/003803857100500236", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/003803857100500236", "abstract": null, "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/1318203", "doi": "10.2307/1318203", "title": "Teaching Applied Sociology: Development of a Graduate-Level Seminar in Clinical Medical Sociology", "publicationYear": 1991, "publicationDate": "1991-07", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "19", "issue": "3", "page": "372", "issn": "0092-055X", "isbn": null, "authors": "Katrina Gabelko, Alan McBride", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1318203", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/0011392107088234", "doi": "10.1177/0011392107088234", "title": "`Make Way for Professional Sociology!'", "publicationYear": 2008, "publicationDate": "2008-05", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Current Sociology", "volume": "56", "issue": "3", "page": "405-414", "issn": "0011-3921, 1461-7064", "isbn": null, "authors": "Elena Zdravomyslova", "authorCount": 1, "firstAuthorAffiliation": "European University at St Petersburg and Centre for Independent Social Research, St Petersburg", "isReferencedByCount": 9, "referenceCount": 9, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/0011392107088234", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/0011392107088234", "abstract": "This article presents the context of the current debate on the status of sociology in Russia, maps the controversy between professional and public sociology and locates the public sociology agenda in the context of a fight for professional sociology using the case of sociological education. To test the thesis of sociological internationalism, it is necessary to take into account local contexts, especially three aspects: the political opportunities for the public sociology manifesto; the situation with respect to civil society (as `a natural location of sociology'); and the level of institutionalization of sociology. All three contexts frame the cultural translation of the public sociology manifesto to the Russian sociological scene.", "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/1317001", "doi": "10.2307/1317001", "title": "Introductory Sociology through Literature", "publicationYear": 1982, "publicationDate": "1982-10", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "10", "issue": "1", "page": "109", "issn": "0092-055X", "isbn": null, "authors": "Teresa A. Sullivan", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 17, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1317001", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/2066204", "doi": "10.2307/2066204", "title": "The Sociology of Power.", "publicationYear": 1979, "publicationDate": "1979-03", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "8", "issue": "2", "page": "320", "issn": "0094-3061", "isbn": null, "authors": "Robert Bierstedt, Roderick Martin", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2066204", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/0038038507080441", "doi": "10.1177/0038038507080441", "title": "Towards Postsecular Sociology?", "publicationYear": 2007, "publicationDate": "2007-10", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "41", "issue": "5", "page": "857-870", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "Gregor McLennan", "authorCount": 1, "firstAuthorAffiliation": "University of Bristol,", "isReferencedByCount": 47, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/0038038507080441", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/0038038507080441", "abstract": "This article identifies four articulations of the growing `postsecular' condition of social and political thought, and places the idea of sociology in relation to them. I identify and critically engage with those aspects of poststructuralist vitalism, transcendental realism, multiculturalist thinking, and the recent `dialogical' sentiments of Habermas that might undermine sociology's definitive (but broadly conceived) secularism/naturalism. This implies that if we are concerned about advancing the role of `public sociology' then we should be actively engaged in countering anti-secular and anti-naturalistic elements of the postsecular climate.Yet we must avoid anthropomorphizing sociology as a public player, and accept too that the postsecular reconsideration of `faith versus reason' stretches beyond the confines of epistemological and explanatory considerations per se.", "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/003803856900300315", "doi": "10.1177/003803856900300315", "title": "Elements of Sociology", "publicationYear": 1969, "publicationDate": "1969-09", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "3", "issue": "3", "page": "427-427", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "Stephen Mennll", "authorCount": 1, "firstAuthorAffiliation": "University of Exeter", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/003803856900300315", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/003803856900300315", "abstract": null, "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/2066041", "doi": "10.2307/2066041", "title": "Philosophy and Sociology.", "publicationYear": 1980, "publicationDate": "1980-03", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "9", "issue": "2", "page": "259", "issn": "0094-3061", "isbn": null, "authors": "George Fischer, G. P. Frantsov", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2066041", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/003803857901300102", "doi": "10.1177/003803857901300102", "title": "Sociology and Utopia", "publicationYear": 1979, "publicationDate": "1979-01", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "13", "issue": "1", "page": "19-33", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "Ruth Levitas", "authorCount": 1, "firstAuthorAffiliation": "Huddersfield Polytechnic", "isReferencedByCount": 19, "referenceCount": 62, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/003803857901300102", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/003803857901300102", "abstract": "The theme of this paper is that the content, form, location and social role of utopia vary with the material conditions in which people live. These variations have been obscured by definitions of utopia in terms of its function in catalysing social change, which has also produced the illusion that the contemporary Western world lacks utopias. By defining utopia with reference to its meaning to author and audience as an expression of their desires and aspirations, it is possible to trace a series of shifts in the English utopia, to relate these to one another and to the social context, and to show that the `absence' of contemporary utopias is simply another transformation of this kind. From being a spatially-located wish-fantasy, utopia moved through the function of social criticism to being a temporally-located catalyst of social change. These changes depended on perceptions of society-in-time as increasingly malleable and open to human control, culminating in the nineteenth century belief in progress. Utopia now appears to have reverted to the role of wish-fantasy as a result of a prevalent fatalism and a shift away from an evolutionary perspective, a change which, paradoxically, allows it to be more utopian by tying it less closely to reality. Utopia as a catalyst of social change depends on an optimism which is now absent.", "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/3089297", "doi": "10.2307/3089297", "title": "Solution-Centered Sociology: Addressing Problems through Applied Sociology", "publicationYear": 2001, "publicationDate": "2001-05", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "30", "issue": "3", "page": "313", "issn": "0094-3061", "isbn": null, "authors": "Jay Weinstein, Stephen F. Steele, AnneMarie Scarisbrick-Hauser, William J. Hauser", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/3089297", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/2655613", "doi": "10.2307/2655613", "title": "Canadian Sociology", "publicationYear": 1997, "publicationDate": "1997-09", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "26", "issue": "5", "page": "543", "issn": "0094-3061", "isbn": null, "authors": "Robert Brym, Celine Saint-Pierre", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2655613", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/1317928", "doi": "10.2307/1317928", "title": "Sociology", "publicationYear": 1989, "publicationDate": "1989-01", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "17", "issue": "1", "page": "73", "issn": "0092-055X", "isbn": null, "authors": "Jean S. Nagle, J. M. Shepard", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1317928", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/1317400", "doi": "10.2307/1317400", "title": "Sociology and Survival 101", "publicationYear": 1992, "publicationDate": "1992-04", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "20", "issue": "2", "page": "154", "issn": "0092-055X", "isbn": null, "authors": "Robert J. Parelius", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1317400", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/1317000", "doi": "10.2307/1317000", "title": "Introductory Sociology", "publicationYear": 1982, "publicationDate": "1982-10", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "10", "issue": "1", "page": "102", "issn": "0092-055X", "isbn": null, "authors": "Roger Steinhauer, Edward Lehman, Dorothy Mariner", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1317000", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/2063421", "doi": "10.2307/2063421", "title": "Sociology in Israel.", "publicationYear": 1976, "publicationDate": "1976-09", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "5", "issue": "5", "page": "698", "issn": "0094-3061", "isbn": null, "authors": "Rivka W. Bar-Yosef, Leonard Weller", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2063421", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/2073800", "doi": "10.2307/2073800", "title": "Soviet Sociology, Past and Present", "publicationYear": 1989, "publicationDate": "1989-05", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "18", "issue": "3", "page": "316", "issn": "0094-3061", "isbn": null, "authors": "Anthony Jones, Vladimir Shlapentokh", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2073800", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/003803857400800213", "doi": "10.1177/003803857400800213", "title": "Book Review: Political Sociology", "publicationYear": 1974, "publicationDate": "1974-05", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "8", "issue": "2", "page": "327-329", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "Philip Abrams", "authorCount": 1, "firstAuthorAffiliation": "University of Durham", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/003803857400800213", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/003803857400800213", "abstract": null, "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/1319086", "doi": "10.2307/1319086", "title": "Teaching the Sociology of Japan", "publicationYear": 1993, "publicationDate": "1993-10", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "21", "issue": "4", "page": "371", "issn": "0092-055X", "isbn": null, "authors": "Kinko Ito", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1319086", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/2065869", "doi": "10.2307/2065869", "title": "Trying Sociology.", "publicationYear": 1977, "publicationDate": "1977-03", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "6", "issue": "2", "page": "258", "issn": "0094-3061", "isbn": null, "authors": "Robert Jackall, Kurt H. Wolff", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2065869", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/2067883", "doi": "10.2307/2067883", "title": "Industrial Sociology.", "publicationYear": 1981, "publicationDate": "1981-01", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "10", "issue": "1", "page": "152", "issn": "0094-3061", "isbn": null, "authors": "Michael R. Smith, Ivar Berg", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2067883", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/003803857400800131", "doi": "10.1177/003803857400800131", "title": "The Sociology of Science", "publicationYear": 1974, "publicationDate": "1974-01", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "8", "issue": "1", "page": "177-178", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "Ivan Waddington", "authorCount": 1, "firstAuthorAffiliation": "University of Leicester", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/003803857400800131", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/003803857400800131", "abstract": null, "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/003803856900300212", "doi": "10.1177/003803856900300212", "title": "Studies in Sociology", "publicationYear": 1969, "publicationDate": "1969-05", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "3", "issue": "2", "page": "254-254", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "N. H. Rankin", "authorCount": 1, "firstAuthorAffiliation": "University of Strathclyde", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/003803856900300212", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/003803856900300212", "abstract": null, "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/001139215500400104", "doi": "10.1177/001139215500400104", "title": "Urban Sociology in France", "publicationYear": 1955, "publicationDate": "1955-03", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Current Sociology", "volume": "4", "issue": "1", "page": "15-16", "issn": "0011-3921, 1461-7064", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/001139215500400104", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/001139215500400104", "abstract": "Prior to the period 1940-54, to which this bibliography is restricted, various types of surveys of some sociological interest had, for a hundred years or so, been carried out in a number of French towns. But despite the large number of individual studies inspired by France's increasing urbanization, no real urban sociology had been built up. This is now gradually coming into existence through an accumulation of recent or current studies, some directed towards theoretical research, others guided by more immediate practical considerations (such as the problems of town-planning). In actual fact, urban sociology seems unlikely to develop, in France, into a specialized branch of sociology. The position is, rather, that town-dwellers offer a common field of investigation to experts in many different subjects. These experts progress thanks to mutual support and—what chiefly interests us—in proportion to the extent that adopt a sociological viewpoint.", "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/00380385221122420", "doi": "10.1177/00380385221122420", "title": "The Sociology of Futurelessness", "publicationYear": 2023, "publicationDate": "2023-04", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Sociology", "volume": "57", "issue": "2", "page": "438-453", "issn": "0038-0385, 1469-8684", "isbn": null, "authors": "Richard Tutton", "authorCount": 1, "firstAuthorAffiliation": "University of York, UK", "isReferencedByCount": 60, "referenceCount": 69, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/00380385221122420", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/00380385221122420", "abstract": "This article contributes to ‘sociologies of the future’ by discussing the concept of ‘futurelessness’. I provide a conceptual elaboration of what is meant by ‘futurelessness’, beginning with its use in the psychological literature of the 1980s concerned with the effect of a constant threat of nuclear war. I argue that this concept is of value to ongoing sociological debates about the relationship between imagined futures, power and social change. I further discuss the extent to which ‘futurelessness’ is a particular mode of relating to and feeling about the future that is characteristic of contemporary European societies. I discuss how this ‘futurelessness’ must be understood in relation to political and cultural developments of the past 50 years and consider its significance for sociological debates about contemporary futurity.", "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/1317799", "doi": "10.2307/1317799", "title": "Using Student Journals in Sociology Courses", "publicationYear": 1984, "publicationDate": "1984-07", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "11", "issue": "4", "page": "419", "issn": "0092-055X", "isbn": null, "authors": "Theodore C. Wagenaar", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 26, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1317799", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/1317705", "doi": "10.2307/1317705", "title": "Sociology Laboratory: Computer Simulations for Learning Sociology", "publicationYear": 1988, "publicationDate": "1988-01", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "16", "issue": "1", "page": "93", "issn": "0092-055X", "isbn": null, "authors": "Bryce Johnson, W. S. Bainbridge", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1317705", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/1318838", "doi": "10.2307/1318838", "title": "Key Ideas in Sociology", "publicationYear": 1998, "publicationDate": "1998-07", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Teaching Sociology", "volume": "26", "issue": "3", "page": "230", "issn": "0092-055X", "isbn": null, "authors": "Clifford L. Staples, Peter Kivisto", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/1318838", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.1177/001139217202000302", "doi": "10.1177/001139217202000302", "title": "The sociology of law", "publicationYear": 1972, "publicationDate": "1972-12", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Current Sociology", "volume": "20", "issue": "3", "page": "13-48", "issn": "0011-3921, 1461-7064", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1177/001139217202000302", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1177/001139217202000302", "abstract": "Intensified efforts to determine the subject matter and research aims of the sociology of law have clarified ideas in the last 12 years. These ideas were, at the beginning, rather diffuse and abstract, as can be seen in Friedmann's report. Admittedly, there is much room for subjective opinions even now for in actuality every important author still creates his own sociology of the law. Yet, by and large, some consensus seems to have been established on certain points. Therefore, at the beginning of our report, a brief résumé of current opinions must be given. This cannot be done without subjectivity, but on the other hand it is necessary to avoid an endless discussion of the different conceptions of what sociology of law can be.", "subject": null, "language": "en", "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/2065721", "doi": "10.2307/2065721", "title": "Medical Sociology.", "publicationYear": 1978, "publicationDate": "1978-11", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "7", "issue": "6", "page": "773", "issn": "0094-3061", "isbn": null, "authors": "Dennis L. Peck, William C. Cockerham", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2065721", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/2069326", "doi": "10.2307/2069326", "title": "The Sociology of Law.", "publicationYear": 1986, "publicationDate": "1986-07", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "15", "issue": "4", "page": "628", "issn": "0094-3061", "isbn": null, "authors": "Robert Bell, Roman Tomasic", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2069326", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
{"paperId": "10.2307/2064552", "doi": "10.2307/2064552", "title": "Images of Sociology and Sociologists in Fiction", "publicationYear": 1979, "publicationDate": "1979-05", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "Contemporary Sociology", "volume": "8", "issue": "3", "page": "356", "issn": "0094-3061", "isbn": null, "authors": "John Kramer", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/2064552", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "p7PpQoMXWt6FRtRUA", "_dataset_id": "GezL0WVY8aGmu6Znd"}
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{"paperId": "10.1016/j.lanepe.2026.101786", "doi": "10.1016/j.lanepe.2026.101786", "title": "Whole genome sequencing in cerebral palsy: a UK paediatric pilot study", "publicationYear": 2026, "publicationDate": "2026-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "The Lancet Regional Health - Europe", "volume": "68", "issue": null, "page": "101786", "issn": "2666-7762", "isbn": null, "authors": "Thiloka E. Ratnaike, Heather H. Pierce, Alison J. Coffey, Joao M.L. Dias, Iain R.L. Kean, Emily Li, Ravi P. More, Dulika S. Sumathipala, Maya Bajracharya, Zoya Kingsbury, Taksina Newington, Anthony S. Rogers, Isabelle Delon, Kate Downes, Yasmin de Alwis, Anna P. Basu, Manal Issa, Catherine Kearney, Amjad H. Khan, Benjamin P. Marlow, Alison Sansome, JooWook Ahn, A Yee Than, Tracy Lau, David R. Bentley, Sarah Bowdin, Evan Reid, Henry Houlden, Sean Humphray, David H. Rowitch", "authorCount": 30, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 28, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Wellcome Trust, Rosetrees Trust, Isaac Newton Trust, NIHR Cambridge Biomedical Research Centre", "funderIds": "10.13039/100010269, 10.13039/501100000833, 10.13039/501100004815, 10.13039/501100018956", "url": "https://doi.org/10.1016/j.lanepe.2026.101786", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "79eLa4H2P2yTzeLFN", "_dataset_id": "I0x3ABWgnlE974bxl"}
{"paperId": "10.1016/j.lansea.2026.100814", "doi": "10.1016/j.lansea.2026.100814", "title": "Healthcare utilisation, expenditure, and admission-based mortality associated with paediatric hepatobiliary diseases in Thailand: a national database analysis (2015–2023)", "publicationYear": 2026, "publicationDate": "2026-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "The Lancet Regional Health - Southeast Asia", "volume": "52", "issue": null, "page": "100814", "issn": "2772-3682", "isbn": null, "authors": "Songpon Getsuwan, Busara Charoenwat, Chatmanee Lertudomphonwanit, Kaewjai Thepsuthammarat, Suporn Treepongkaruna, Sumitr Sutra", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Khon Kaen University", "funderIds": "10.13039/501100004071", "url": "https://doi.org/10.1016/j.lansea.2026.100814", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "79eLa4H2P2yTzeLFN", "_dataset_id": "I0x3ABWgnlE974bxl"}
{"paperId": "10.1016/j.lanepe.2026.101768", "doi": "10.1016/j.lanepe.2026.101768", "title": "Prolonged CD38 targeting with felzartamab in antibody-mediated kidney transplant rejection: a biomarker-guided open-label phase 2 extension", "publicationYear": 2026, "publicationDate": "2026-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "The Lancet Regional Health - Europe", "volume": "68", "issue": null, "page": "101768", "issn": "2666-7762", "isbn": null, "authors": "Katharina A. Mayer, Matthias Diebold, Eva V. Schrezenmeier, Philip F. Halloran, Susanne Haindl, Martina Schatzl, Aylin Akifova, Daniela M. Allmer, Sabine Schranz, Nicolas Kozakowski, Johannes Kläger, Kerstin Amann, Julia Beck, Ekkehard Schütz, Maarten Naesens, Alexandre Loupy, Marc Raynaud, Irene Görzer, Hannes Vietzen, Gordon Ingle, Donna L. Flesher, Uptal D. Patel, Fabian Halleck, Irene Graf, Bernd Jilma, Klemens Budde, Georg A. Böhmig", "authorCount": 27, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 26, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Biogen Inc", "funderIds": "10.13039/100005614", "url": "https://doi.org/10.1016/j.lanepe.2026.101768", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "79eLa4H2P2yTzeLFN", "_dataset_id": "I0x3ABWgnlE974bxl"}
{"paperId": "10.1016/j.lanepe.2026.101788", "doi": "10.1016/j.lanepe.2026.101788", "title": "Hospital acquisitions and 30-day mortality after acute myocardial infarction and stroke in Germany: a quasi-experimental cohort study", "publicationYear": 2026, "publicationDate": "2026-09", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "The Lancet Regional Health - Europe", "volume": "68", "issue": null, "page": "101788", "issn": "2666-7762", "isbn": null, "authors": "Esra Eren Bayindir, Reinhard Busse, Jonas Schreyögg", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "German Research Foundation", "funderIds": "10.13039/501100001659", "url": "https://doi.org/10.1016/j.lanepe.2026.101788", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "79eLa4H2P2yTzeLFN", "_dataset_id": "I0x3ABWgnlE974bxl"}
{"paperId": "10.1073/pnas.2417269122", "doi": "10.1073/pnas.2417269122", "title": "Modulating the microbiome as an approach to anticancer drug development", "publicationYear": 2025, "publicationDate": "2025-11-04", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "122", "issue": "44", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Jemma Arakelyan, Ho-Jung Choe, Chengnan Wu, Daniil A. Rusanov, Elena E. Bardina, Anna A. Kirsanova, Yuliya V. Zakalyukina, Nikita Y. Shmelev, Anton P. Tyurin, Vladislav Y. Komarov, Vladimir Kushnarev, Nikolay S. Karnaukhov, Gerald D’Cruz, Eugene S. Vasilyev, Eunice Dotse, Kwan T. Chow, William C. Cho, Alexey V. Tkachev, Artem L. Gushchin, Maria V. Babak", "authorCount": 20, "firstAuthorAffiliation": "Department of Chemistry, Drug Discovery Lab, City University of Hong Kong", "isReferencedByCount": 4, "referenceCount": 74, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "Pneumoconiosis Compensation Fund Board of Hong Kong, Russian Science Foundation, the Ministry of Science and Higher Education of the Russian Federation, the Ministry of Science and Higher Education of the Russian Federation, Russian Science Foundation, Croucher Foundation, Croucher Foundation, Hong Kong Research Grants Council, Hong Kong Research Grants Council", "funderIds": "10.13039/501100006769, 10.13039/501100006769, 10.13039/501100001692, 10.13039/501100001692", "url": "https://doi.org/10.1073/pnas.2417269122", "pdfUrl": null, "abstract": "Recent studies have suggested that the commensal microbiome positively affects cancer prognosis and treatment outcomes. However, only a few strategies for regulating the microbiome composition have been reported. In this study, we identified gold(I) complexes that selectively inhibited nonbeneficial bacterial strains in vitro without affecting commensal Lactobacillus strains. In contrast, clinically used drugs demonstrated comparable effects on both commensal and noncommensal strains. Consistent with the in vitro results, the selected gold(I) complex induced favorable changes in the intratumoral and gastrointestinal microbiomes in vivo. Furthermore, its anticancer efficacy was found to be dependent on the composition of microbiome and correlated with the production of short-chain fatty acid bacterial metabolites. Structure–activity relationship studies have dissected the contribution of each structural component in both the in vivo efficacy and microbiome-modulating properties. Transcriptomic analysis of tumors revealed microbiome-associated gene signaling pathways. These findings provide valuable insights for future research on microbiome-modulating anticancer drugs, presenting potential avenues to optimize cancer treatment outcomes and mitigate side effects such as gastrointestinal dysbiosis. Furthermore, our study provides insights into the involvement of microbiome in the mechanism of action of metal-based chemotherapeutics.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.131179698", "doi": "10.1073/pnas.131179698", "title": "Crystal structure of an anticoagulant protein in complex with the Gla domain of factor X", "publicationYear": 2001, "publicationDate": "2001-06-19", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "98", "issue": "13", "page": "7230-7234", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Hiroshi Mizuno, Zui Fujimoto, Hideko Atoda, Takashi Morita", "authorCount": 4, "firstAuthorAffiliation": "Department of Biotechnology, National Institute of Agrobiological Resources, Tsukuba, Ibaraki 305-8602, Japan; and Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588, Japan", "isReferencedByCount": 121, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.131179698", "pdfUrl": null, "abstract": "The γ-carboxyglutamic acid (Gla) domain of blood coagulation factors is responsible for Ca 2+ -dependent phospholipid membrane binding. Factor X-binding protein (X-bp), an anticoagulant protein from snake venom, specifically binds to the Gla domain of factor X. The crystal structure of X-bp in complex with the Gla domain peptide of factor X at 2.3-Å resolution showed that the anticoagulation is based on the fact that two patches of the Gla domain essential for membrane binding are buried in the complex formation. The Gla domain thus is expected to be a new target of anticoagulant drugs, and X-bp provides a basis for designing them. This structure also provides a membrane-bound model of factor X.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1905489116", "doi": "10.1073/pnas.1905489116", "title": "The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage", "publicationYear": 2019, "publicationDate": "2019-09-03", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "116", "issue": "36", "page": "17980-17989", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Qian Zhang, Ryan C. Riddle, Qian Yang, Clifford R. Rosen, Denis C. Guttridge, Naomi Dirckx, Marie-Claude Faugere, Charles R. Farber, Thomas L. Clemens", "authorCount": 9, "firstAuthorAffiliation": "Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD 21287;", "isReferencedByCount": 106, "referenceCount": 58, "isOpenAccess": true, "licenseUrl": "https://www.pnas.org/site/aboutpnas/licenses.xhtml", "funderNames": "VA Merit Review grant, NIH grant", "funderIds": null, "url": "https://doi.org/10.1073/pnas.1905489116", "pdfUrl": null, "abstract": "Significance Like other complex disorders, such as diabetes and obesity, osteoporosis is strongly influenced by genetic factors. In this study, we explored the function of the fat mass and obesity-associated gene (FTO), an RNA demethyase that has been strongly linked by genome-wide association studies to obesity and bone density. We show that loss of Fto in mouse osteoblasts leads to age-related bone loss with increased susceptibility of osteoblasts to cell death. RNA profiling of osteoblasts lacking Fto prioritized FTO targets that are members of the DNA repair pathway, which are activated in response to genotoxic stimuli. Our results identify an epigenetic pathway in which FTO normally functions in bone to enhance the stability of mRNA-encoding proteins that protect osteoblasts from genotoxic damage.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2220523120", "doi": "10.1073/pnas.2220523120", "title": "Subspace partitioning in the human prefrontal cortex resolves cognitive interference", "publicationYear": 2023, "publicationDate": "2023-07-11", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "120", "issue": "28", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Jan Weber, Gabriela Iwama, Anne-Kristin Solbakk, Alejandro O. Blenkmann, Pal G. Larsson, Jugoslav Ivanovic, Robert T. Knight, Tor Endestad, Randolph Helfrich", "authorCount": 9, "firstAuthorAffiliation": "Hertie Institute for Clinical Brain Research, Center for Neurology, University Medical Center Tübingen, 72076 Tübingen, Germany", "isReferencedByCount": 44, "referenceCount": 65, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "Deutsche Forschungsgemeinschaft, Research Council Norway, Research Council Norway, Research Council Norway, Research Council Norway, Research Council Norway, Research Council Norway, Research Council Norway, HHS | NIH | National Institute of Mental Health, HHS | NIH | National Institute of Neurological Disorders and Stroke", "funderIds": "10.13039/501100001659, 10.13039/100000025, 10.13039/100000065", "url": "https://doi.org/10.1073/pnas.2220523120", "pdfUrl": null, "abstract": "The human prefrontal cortex (PFC) constitutes the structural basis underlying flexible cognitive control, where mixed-selective neural populations encode multiple task features to guide subsequent behavior. The mechanisms by which the brain simultaneously encodes multiple task–relevant variables while minimizing interference from task-irrelevant features remain unknown. Leveraging intracranial recordings from the human PFC, we first demonstrate that competition between coexisting representations of past and present task variables incurs a behavioral switch cost. Our results reveal that this interference between past and present states in the PFC is resolved through coding partitioning into distinct low-dimensional neural states; thereby strongly attenuating behavioral switch costs. In sum, these findings uncover a fundamental coding mechanism that constitutes a central building block of flexible cognitive control.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.94.9.4675", "doi": "10.1073/pnas.94.9.4675", "title": "A proline-rich motif in p53 is required for transactivation- independent growth arrest as induced by Gas1", "publicationYear": 1997, "publicationDate": "1997-04-29", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "94", "issue": "9", "page": "4675-4680", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Elisabetta M. Ruaro, Licio Collavin, Giannino Del Sal, Rebecca Haffner, Moshe Oren, Arnold J. Levine, Claudio Schneider", "authorCount": 7, "firstAuthorAffiliation": "Laboratorio Nazionale Consorzio Interuniversitario per le Biotecnologie and International Centre for Genetic Engineering and Biotechnology, Area Science Park Padriciano 99, 34012 Trieste, Italy; Dipartimento di Biochimica Biofisica e Chimica delle Macromolecole, Via L. Giorgeri 1, Universita’degli Studi 34100 Trieste, Italy; Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel; and Department of Molecular Biology, Lewis Thomas Building, Washington Road,...", "isReferencedByCount": 81, "referenceCount": 46, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.94.9.4675", "pdfUrl": null, "abstract": "The involvement of p53 in regulating diverse cellular processes dictates that it must respond to multiple signaling mechanisms, thus coordinating the response to various “stress conditions.” Genotoxic stress has served as a paradigm to dissect the transactivation-dependent branch of the pathway by which p53 can induce growth arrest. Alternate mechanisms have been invoked to explain transactivation-independent effects of p53, especially in the context of apoptosis. We have identified a p53-dependent pathway initiated by the gas1 product, a plasma membrane protein highly expressed during G0, which activates a transactivation-independent p53 growth arrest function. Through a detailed deletional analysis and site-specific mutagenesis of p53 we show that the Gas1-dependent signal transduction relies on a proline-rich region (amino acids 63–85) of murine p53. In vivo competition experiments using combinations of such mutants implicate this functional domain of p53 as a docking site in the transmission of antiproliferative signals.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2426241122", "doi": "10.1073/pnas.2426241122", "title": "Transpupillary in vivo two-photon imaging reveals enhanced surveillance of retinal microglia in diabetic mice", "publicationYear": 2025, "publicationDate": "2025-10-14", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "122", "issue": "41", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Noriyuki Sotani, Sentaro Kusuhara, Ryuto Nishisho, Hiroto Kuno, Hidenori Shima, Koichiro Haruwaka, Yuka Mori, Maya Kishi, Tomoyuki Furuyashiki, Kenta Kobayashi, Hiroaki Wake, Toru Takumi, Makoto Nakamura, Yoshihisa Tachibana", "authorCount": 14, "firstAuthorAffiliation": "Department of Physiology and Cell Biology, Kobe University", "isReferencedByCount": 6, "referenceCount": 59, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "MEXT | Japan Science and Technology Agency, Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science London, Japan Society for the Promotion of Science London, Japan Society for the Promotion of Science London, Japan Society for the Promotion of Science London", "funderIds": "10.13039/501100002241, 10.13039/100009619, 10.13039/501100000646, 10.13039/501100000646, 10.13039/501100000646, 10.13039/501100000646", "url": "https://doi.org/10.1073/pnas.2426241122", "pdfUrl": "https://pnas.org/doi/pdf/10.1073/pnas.2426241122", "abstract": "The retina, located outside the cranium, serves as an ideal structure for investigating information processing within the central nervous system due to its well-organized neurovascular unit comprising diverse cell types, including neurons, glial cells (such as microglia, Müller glia, and astrocytes), pericytes, and vascular endothelial cells. Disrupted retinal homeostasis contributes to various ocular diseases such as diabetic retinopathy, age-related macular degeneration, glaucoma, and retinitis pigmentosa. However, noninvasive in vivo imaging methods to study the pathogenesis of these disorders remain limited. Here, we developed a two-photon microscopy technique for real-time, transpupillary in vivo visualization of the retinal neurovascular unit in mice. Our approach integrates systematic head fixation, a custom-made polymethyl methacrylate contact lens, and a glycerin immersion objective lens with an extended working distance and a higher numerical aperture, specifically designed for two-photon microscopy. This method enabled us to visualize dynamic microglial process activity around retinal blood vessels. Our results revealed that retinal microglia exhibit enhanced surveillance under diabetic conditions, which is undetectable by static confocal microscopy. Furthermore, we demonstrated that liraglutide, a glucagon-like peptide-1 receptor agonist commonly used for the treatment of diabetes and obesity, reversed the enhanced microglial behaviors in the diabetic retina. Our simple yet effective approach mitigates the need for advanced optical systems like adaptive optics, providing an effective tool for real-time imaging of the retina. This method offers a valuable resource for visual neuroscience research and holds great potential for clinical applications, particularly in the early diagnosis, intervention, and monitoring of retinal diseases.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1818598116", "doi": "10.1073/pnas.1818598116", "title": "Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation", "publicationYear": 2019, "publicationDate": "2019-03-12", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "116", "issue": "11", "page": "5061-5070", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Michael A. Davis, Marian R. Fairgrieve, Andreas Den Hartigh, Olga Yakovenko, Bhargavi Duvvuri, Christian Lood, Wendy E. Thomas, Susan L. Fink, Michael Gale", "authorCount": 9, "firstAuthorAffiliation": "Department of Immunology, University of Washington, Seattle, WA 98109;", "isReferencedByCount": 102, "referenceCount": 52, "isOpenAccess": true, "licenseUrl": "https://www.pnas.org/site/aboutpnas/licenses.xhtml", "funderNames": "HHS | NIH | National Institute of Allergy and Infectious Diseases, HHS | NIH | National Institute of Allergy and Infectious Diseases, HHS | NIH | National Institute of Allergy and Infectious Diseases, HHS | NIH | National Institute of Allergy and Infectious Diseases, HHS | NIH | National Institute of Allergy and Infectious Diseases, HHS | NIH | National Institute of Allergy and Infectious Diseases, HHS | NIH | National Institute of Allergy and Infectious Diseases, Alliance for Lupus Research", "funderIds": "10.13039/100000060, 10.13039/100000060, 10.13039/100000060, 10.13039/100000060, 10.13039/100000060, 10.13039/100000060, 10.13039/100000060, 10.13039/100007820", "url": "https://doi.org/10.1073/pnas.1818598116", "pdfUrl": null, "abstract": "Significance Pyroptosis is a form of inflammatory cell death. It is driven by plasma membrane pore formation that is thought to rupture cells through osmotic influx, thereby releasing intracellular content that initiates an inflammatory response to fight acute infection and tissue damage. However, when chronic or unregulated, this process can drive autoimmune disease and cancer. Here, we show that pyroptotic cells do not undergo rupture in culture. Instead, the calcium-dependent protease calpain destroys intermediate filaments, which provide mechanical resilience to cells. As a result, cells are susceptible to rupture by mechanical disruption from shear stress or compression as occurs in the blood stream or within tissues. Thus, our data reveal potential targets for the therapeutic intervention of autoimmune diseases and cancer.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1421784112", "doi": "10.1073/pnas.1421784112", "title": "Genome-wide ancestry of 17th-century enslaved Africans from the Caribbean", "publicationYear": 2015, "publicationDate": "2015-03-24", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "112", "issue": "12", "page": "3669-3673", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Hannes Schroeder, María C. Ávila-Arcos, Anna-Sapfo Malaspinas, G. David Poznik, Marcela Sandoval-Velasco, Meredith L. Carpenter, José Víctor Moreno-Mayar, Martin Sikora, Philip L. F. Johnson, Morten Erik Allentoft, José Alfredo Samaniego, Jay B. Haviser, Michael W. Dee, Thomas W. Stafford, Antonio Salas, Ludovic Orlando, Eske Willerslev, Carlos D. Bustamante, M. Thomas P. Gilbert", "authorCount": 19, "firstAuthorAffiliation": "Centre for Geogenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen, Denmark;", "isReferencedByCount": 109, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": "http://www.pnas.org/site/misc/userlicense.xhtml", "funderNames": "European Commission Directorate-General for Research and Innovation, EC | European Research Council, European Commission Directorate-General for Research and Innovation, EC | European Research Council, Det Frie Forskningsråd, Lundbeckfonden, NSF | MPS | Division of Mathematical Sciences, NSF | EHR | Division of Graduate Education, Swiss National Science Foundation, HHS | National Institutes of Health, HHS | National Institutes of Health, Leverhulme Trust, Ministerio de Ciencia e Innovación, Danish National Research Foundation", "funderIds": "10.13039/100004431, 10.13039/501100000781, 10.13039/100004431, 10.13039/501100000781, 10.13039/501100004836, 10.13039/501100003554, 10.13039/100000121, 10.13039/100000082, 10.13039/501100001711, 10.13039/100000002, 10.13039/100000002, 10.13039/501100000275, 10.13039/501100004837, 10.13039/501100001732", "url": "https://doi.org/10.1073/pnas.1421784112", "pdfUrl": null, "abstract": "Significance The transatlantic slave trade resulted in the forced movement of over 12 million Africans to the Americas. Although many coastal shipping points are known, they do not necessarily reflect the slaves’ actual ethnic or geographic origins. We obtained genome-wide data from 17th-century remains of three enslaved individuals who died on the Caribbean island of Saint Martin and use them to identify their genetic origins in Africa, with far greater precision than previously thought possible. The study demonstrates that genomic data can be used to trace the genetic ancestry of long-dead individuals, a finding that has important implications for archeology, especially in cases where historical information is missing.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.96.5.2036", "doi": "10.1073/pnas.96.5.2036", "title": "The two-dimensional IR nonlinear spectroscopy of a cyclic penta-peptide in relation to its three-dimensional structure", "publicationYear": 1999, "publicationDate": "1999-03-02", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "96", "issue": "5", "page": "2036-2041", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Peter Hamm, Manho Lim, William F. DeGrado, Robin M. Hochstrasser", "authorCount": 4, "firstAuthorAffiliation": "Department of Chemistry and Department of\r Biochemistry and Biophysics, The Johnson Foundation for Research in\r Biophysics, University of Pennsylvania, Philadelphia, PA 19104", "isReferencedByCount": 345, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.96.5.2036", "pdfUrl": null, "abstract": "A form of two-dimensional (2D) vibrational spectroscopy, which uses two ultrafast IR laser pulses, is used to examine the structure of a cyclic penta-peptide in solution. Spectrally resolved cross peaks occur in the off-diagonal region of the 2D IR spectrum of the amide I region, analogous to those in 2D NMR spectroscopy. These cross peaks measure the coupling between the different amide groups in the structure. Their intensities and polarizations relate directly to the three-dimensional structure of the peptide. With the help of a model coupling Hamiltonian, supplemented by density functional calculations, the spectra of this penta-peptide can be regenerated from the known solution phase structure. This 2D-IR measurement, with an intrinsic time resolution of less than 1 ps, could be used in all time regimes of interest in biology.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.94.8.4109", "doi": "10.1073/pnas.94.8.4109", "title": "Disaggregation of Alzheimer β-amyloid by site-directed mAb", "publicationYear": 1997, "publicationDate": "1997-04-15", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "94", "issue": "8", "page": "4109-4112", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Beka Solomon, Rela Koppel, Dan Frankel, Eilat Hanan-Aharon", "authorCount": 4, "firstAuthorAffiliation": "Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69978, Israel", "isReferencedByCount": 341, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.94.8.4109", "pdfUrl": null, "abstract": "In Alzheimer disease, β-amyloid peptide accumulates in the brain as insoluble amyloid plaques. Amyloid filaments, similar to those found in amyloid plaques, can be assembled in vitro from chemically synthesized β-peptides. In this study, we report that antibodies raised against the N-terminal region (1–28) of the β-amyloid peptide bind to the in vitro -formed β-amyloid assemblies, leading to disaggregation of the fibrils and partial restoration of the peptide’s solubility. The concomitant addition of fibrillar β-amyloid with these antibodies to PC 12 cells leads to the inhibition of the neurotoxic effects of β-amyloid. Some of the mAbs raised against soluble β-peptide (1–28) have been found to prevent in vitro fibrillar aggregation of β-amyloid peptide. These experimental data suggest that site-directed mAbs interfere with the aggregation of β-amyloid and trigger reversal to its nontoxic, normal components. The above findings give hints on how to convert in vivo senile plaques into nontoxic, diffuse components and may have therapeutic interest for those studying Alzheimer disease and other human diseases related to amyloidogenic properties of physiological peptides and proteins.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1406763111", "doi": "10.1073/pnas.1406763111", "title": "Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages", "publicationYear": 2014, "publicationDate": "2014-07-29", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "111", "issue": "30", "page": "11109-11114", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Alex Betts, Oliver Kaltz, Michael E. Hochberg", "authorCount": 3, "firstAuthorAffiliation": "Institut des Sciences de l'Evolution, Université Montpellier II, Unité Mixte de Recherche 5554, 34095 Montpellier Cedex 05, France;", "isReferencedByCount": 115, "referenceCount": 69, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.1406763111", "pdfUrl": null, "abstract": "Significance Scientists have long debated the dynamic form of perpetual reciprocal adaptations, or coevolution, between hosts and their parasites. The two main types of antagonistic coevolution described to date are arms race dynamics, in which interaction traits escalate through time, and fluctuating selection dynamics, in which traits cycle through time. We used experimental evolution between Pseudomonas aeruginosa and a panel of its lytic phages and found the full known range of coevolutionary dynamics. We argue that the coevolutionary pattern is determined by whether phages typically adsorb directly to receptors on the bacterial outer membrane or instead use retractable type IV pili as a primary or alternative site. Our results have applications in the use of phages as therapeutics or disinfectants to control bacterial pathogens.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2211616119", "doi": "10.1073/pnas.2211616119", "title": "Substitutions near the HA receptor binding site explain the origin and major antigenic change of the B/Victoria and B/Yamagata lineages", "publicationYear": 2022, "publicationDate": "2022-10-18", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "119", "issue": "42", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Miruna E. Rosu, Pascal Lexmond, Theo M. Bestebroer, Blake M. Hauser, Derek J. Smith, Sander Herfst, Ron A. M. Fouchier", "authorCount": 7, "firstAuthorAffiliation": "Department of Viroscience, Erasmus Medical Centre, Rotterdam 3015 CE, The Netherlands", "isReferencedByCount": 53, "referenceCount": 48, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "EC | Horizon 2020 Framework Programme, HHS | NIH | National Institute of Allergy and Infectious Diseases", "funderIds": "10.13039/100010661, 10.13039/100000060", "url": "https://doi.org/10.1073/pnas.2211616119", "pdfUrl": null, "abstract": "Influenza B virus primarily infects humans, causing seasonal epidemics globally. Two antigenic variants—Victoria-like and Yamagata-like—were detected in the 1980s, of which the molecular basis of emergence is still incompletely understood. Here, the antigenic properties of a unique collection of historical virus isolates, sampled from 1962 to 2000 and passaged exclusively in mammalian cells to preserve antigenic properties, were determined with the hemagglutination inhibition assay and an antigenic map was built to quantify and visualize the divergence of the lineages. The antigenic map revealed only three distinct antigenic clusters—Early, Victoria, and Yamagata—with relatively little antigenic diversity in each cluster until 2000. Viruses with Victoria-like antigenic properties emerged around 1972 and diversified subsequently into two genetic lineages. Viruses with Yamagata-like antigenic properties evolved from one lineage and became clearly antigenically distinct from the Victoria-like viruses around 1988. Recombinant mutant viruses were tested to show that insertions and deletions (indels), as observed frequently in influenza B virus hemagglutinin, had little effect on antigenic properties. In contrast, amino-acid substitutions at positions 148, 149, 150, and 203, adjacent to the hemagglutinin receptor binding site, determined the main antigenic differences between the Early, Victoria-like, and Yamagata-like viruses. Surprisingly, substitutions at two of the four positions reverted in recent viruses of the Victoria lineage, resulting in antigenic properties similar to viruses circulating ∼50 y earlier. These data shed light on the antigenic diversification of influenza viruses and suggest there may be limits to the antigenic evolution of influenza B virus.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1318738111", "doi": "10.1073/pnas.1318738111", "title": "Noise differentially impacts phoneme representations in the auditory and speech motor systems", "publicationYear": 2014, "publicationDate": "2014-05-13", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "111", "issue": "19", "page": "7126-7131", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Yi Du, Bradley R. Buchsbaum, Cheryl L. Grady, Claude Alain", "authorCount": 4, "firstAuthorAffiliation": "Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, ON, Canada M6A 2E1; and", "isReferencedByCount": 209, "referenceCount": 37, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.1318738111", "pdfUrl": null, "abstract": "Significance Contentious debate remains regarding the role of the redundant motor activation during speech perception. In this functional MRI study, multivariate pattern analysis revealed stronger multivoxel phoneme discrimination in speech motor regions than auditory cortices when the speech phonemes were moderately degraded by noise. Our findings provide neuroimaging evidence for the sensorimotor integration account. Preserved phoneme discrimination in speech motor areas may compensate for loss of specificity in noise-impoverished speech representations, which aids speech perception under adverse listening conditions.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.0503017102", "doi": "10.1073/pnas.0503017102", "title": "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL", "publicationYear": 2005, "publicationDate": "2005-07-19", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "102", "issue": "29", "page": "10094-10098", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Stephanie E. Kong, Charles A. S. Banks, Ali Shilatifard, Joan Weliky Conaway, Ronald C. Conaway", "authorCount": 5, "firstAuthorAffiliation": "Stowers Institute for Medical Research, Kansas City, MO 64110; Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University Health Sciences Center, St. Louis, MO 63104; Department of Biochemistry and Molecular Biology, Kansas University Medical Center, Kansas City, KS 66160; and Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190", "isReferencedByCount": 87, "referenceCount": 22, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.0503017102", "pdfUrl": null, "abstract": "In human cells, the ELL family of transcription factors includes at least three members, which are all capable of stimulating the overall rate of elongation by RNA polymerase II by suppressing transient pausing by the enzyme at many sites along DNA. In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity. Our findings provide insights into the structure and function of ELL family transcription factors, and they bring to light direct roles for the EAF proteins in regulation of RNA polymerase II transcription.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2312556121", "doi": "10.1073/pnas.2312556121", "title": "Spatiotemporal trends of hemorrhagic fever with renal syndrome (HFRS) in China under climate variation", "publicationYear": 2024, "publicationDate": "2024-01-23", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "121", "issue": "4", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Yuchen Wang, Chutian Zhang, Jing Gao, Ziqi Chen, Zhao Liu, Jianbin Huang, Yidan Chen, Zhichao Li, Nan Chang, Yuxin Tao, Hui Tang, Xuejie Gao, Ying Xu, Can Wang, Dong Li, Xiaobo Liu, Jingxiang Pan, Wenjia Cai, Peng Gong, Yong Luo, Wannian Liang, Qiyong Liu, Nils Chr. Stenseth, Ruifu Yang, Lei Xu", "authorCount": 25, "firstAuthorAffiliation": "Vanke School of Public Health, Tsinghua University, Beijing 100084, China", "isReferencedByCount": 33, "referenceCount": 56, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.2312556121", "pdfUrl": null, "abstract": "Hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease caused by the rodent-transmitted orthohantaviruses (HVs), with China possessing the most cases globally. The virus hosts in China are Apodemus agrarius and Rattus norvegicus , and the disease spread is strongly influenced by global climate dynamics. To assess and predict the spatiotemporal trends of HFRS from 2005 to 2098, we collected historical HFRS data in mainland China (2005–2020), historical and projected climate and population data (2005–2098), and spatial variables including biotic, environmental, topographical, and socioeconomic. Spatiotemporal predictions and mapping were conducted under 27 scenarios incorporating multiple integrated representative concentration pathway models and population scenarios. We identify the type of magistral HVs host species as the best spatial division, including four region categories. Seven extreme climate indices associated with temperature and precipitation have been pinpointed as key factors affecting the trends of HFRS. Our predictions indicate that annual HFRS cases will increase significantly in 62 of 356 cities in mainland China. Rattus regions are predicted to be the most active, surpassing Apodemus and Mixed regions. Eighty cities are identified as at severe risk level for HFRS, each with over 50 reported cases annually, including 22 new cities primarily located in East China and Rattus regions after 2020, while 6 others develop new risk. Our results suggest that the risk of HFRS will remain high through the end of this century, with Rattus norvegicus being the most active host, and that extreme climate indices are significant risk factors. Our findings can inform evidence-based policymaking regarding future risk of HFRS.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1903579116", "doi": "10.1073/pnas.1903579116", "title": "A pair of native fungal pathogens drives decline of a new invasive herbivore", "publicationYear": 2019, "publicationDate": "2019-05-07", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "116", "issue": "19", "page": "9178-9180", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Eric H. Clifton, Louela A. Castrillo, Andrii Gryganskyi, Ann E. Hajek", "authorCount": 4, "firstAuthorAffiliation": "Department of Entomology, Cornell University, Ithaca, NY 14853-2601;", "isReferencedByCount": 50, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "USDA | Animal and Plant Health Inspection Service, USDA | U.S. Forest Service", "funderIds": "10.13039/100009168, 10.13039/100006959", "url": "https://doi.org/10.1073/pnas.1903579116", "pdfUrl": null, "abstract": "Two North American fungal pathogens caused a coepizootic leading to localized collapse of an outbreak population of the newly invasive planthopper pest, the spotted lanternfly ( Lycorma delicatula ), in the eastern United States. The pathogens partitioned the habitat, with the majority of L. delicatula on tree trunks killed by Batkoa major , while cadavers of L. delicatula killed by Beauveria bassiana were usually on the ground. The future will show whether these pathogens will be drivers in boom–bust cycles or will result in recurrent low population densities of this new invasive species.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2507837122", "doi": "10.1073/pnas.2507837122", "title": "Fossil fuel methane emissions likely underestimated in a model based on atmospheric δ <sup>13</sup> C trends", "publicationYear": 2025, "publicationDate": "2025-06-24", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "122", "issue": "25", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Benjamin T. Uveges, Robert W. Howarth, Jed P. Sparks", "authorCount": 3, "firstAuthorAffiliation": "Department of Ecology and Evolutionary Biology, Cornell University", "isReferencedByCount": 2, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.2507837122", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2216192120", "doi": "10.1073/pnas.2216192120", "title": "Distinct early and late neural mechanisms regulate feature-specific sensory adaptation in the human visual system", "publicationYear": 2023, "publicationDate": "2023-02-07", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "120", "issue": "6", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Reuben Rideaux, Rebecca K. West, Dragan Rangelov, Jason B. Mattingley", "authorCount": 4, "firstAuthorAffiliation": "Queensland Brain Institute, The University of Queensland, St. Lucia 4072, Australia", "isReferencedByCount": 47, "referenceCount": 48, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "Department of Education and Training | Australian Research Council, DHAC | National Health and Medical Research Council, DHAC | National Health and Medical Research Council", "funderIds": "10.13039/501100000923, 10.13039/501100000925, 10.13039/501100000925", "url": "https://doi.org/10.1073/pnas.2216192120", "pdfUrl": null, "abstract": "A canonical feature of sensory systems is that they adapt to prolonged or repeated inputs, suggesting the brain encodes the temporal context in which stimuli are embedded. Sensory adaptation has been observed in the central nervous systems of many animal species, using techniques sensitive to a broad range of spatiotemporal scales of neural activity. Two competing models have been proposed to account for the phenomenon. One assumes that adaptation reflects reduced neuronal sensitivity to sensory inputs over time (the “fatigue” account); the other posits that adaptation arises due to increased neuronal selectivity (the “sharpening” account). To adjudicate between these accounts, we exploited the well-known “tilt aftereffect”, which reflects adaptation to orientation information in visual stimuli. We recorded whole-brain activity with millisecond precision from human observers as they viewed oriented gratings before and after adaptation, and used inverted encoding modeling to characterize feature-specific neural responses. We found that both fatigue and sharpening mechanisms contribute to the tilt aftereffect, but that they operate at different points in the sensory processing cascade to produce qualitatively distinct outcomes. Specifically, fatigue operates during the initial stages of processing, consistent with tonic inhibition of feedforward responses, whereas sharpening occurs ~200 ms later, consistent with feedback or local recurrent activity. Our findings reconcile two major accounts of sensory adaptation, and reveal how this canonical process optimizes the detection of change in sensory inputs through efficient neural coding.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.0401343101", "doi": "10.1073/pnas.0401343101", "title": "CCAAT displacement protein/ <i>cut</i> homolog recruits G9a histone lysine methyltransferase to repress transcription", "publicationYear": 2004, "publicationDate": "2004-08-03", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "101", "issue": "31", "page": "11257-11262", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Hitomi Nishio, Martin J. Walsh", "authorCount": 2, "firstAuthorAffiliation": "Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029", "isReferencedByCount": 121, "referenceCount": 37, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.0401343101", "pdfUrl": null, "abstract": "CCAAT displacement protein/ cut homolog (CDP/ cut ) is a highly conserved homeodomain protein that contains three cut repeat sequences. CDP/ cut is a transcriptional factor for many diverse cellular and viral genes that are involved in most cellular processes, including differentiation, development, and proliferation. Here, we report that CDP/ cut interacts with a histone lysine methyltransferase (HKMT), G9a, in vivo and in vitro . The deletion of the cut repeats within CDP/ cut abrogates the interaction with G9a. The transcriptional repressor function of CDP/ cut is mediated through HKMT activity of G9a associated with CDP/ cut . We show that the recruitment of G9a to the human p21 waf1/cdi1 promoter is contingent on the interaction with CDP/ cut , and CDP/ cut is directly associated with an increase in the methylation in vivo of Lys-9 in histone H3 within the CDP/ cut -regulatory region of the p21 waf1/cdi1 promoter. The endogenous level of p21 waf1/cdi1 expression is repressed through CDP/ cut and mediated by HKMT activity of G9a. Furthermore, we report the identification of G9a as a component of CDP/ cut complex. G9a colocalizes with CDP/ cut in the nucleus. These results indicate that G9a functions as a transcriptional corepressor in association with a CDP/ cut complex. These studies now reveal the interaction of G9a with a sequence-specific transcription factor that regulates gene repression through CDP/ cut .", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.0911674106", "doi": "10.1073/pnas.0911674106", "title": "Rapid β-lactam-induced lysis requires successful assembly of the cell division machinery", "publicationYear": 2009, "publicationDate": "2009-12-22", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "106", "issue": "51", "page": "21872-21877", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Hak Suk Chung, Zhizhong Yao, Nathan W. Goehring, Roy Kishony, Jon Beckwith, Daniel Kahne", "authorCount": 6, "firstAuthorAffiliation": "Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138; and", "isReferencedByCount": 117, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.0911674106", "pdfUrl": null, "abstract": "β-lactam antibiotics inhibit penicillin binding proteins (PBPs) involved in peptidoglycan synthesis. Although inhibition of peptidoglycan biosynthesis is generally thought to induce cell lysis, the pattern and mechanism of cell lysis can vary substantially. β-lactams that inhibit FtsI, the only division specific PBP, block cell division and result in growth as filaments. These filaments ultimately lyse through a poorly understood mechanism. Here we find that one such β-lactam, cephalexin, can, under certain conditions, lead instead to rapid lysis at nascent division sites through a process that requires the complete and ordered assembly of the divisome, the essential machinery involved in cell division. We propose that this assembly process (in which the localization of cell wall hydrolases depends on properly targeted FtsN, which in turn depends on the presence of FtsI) ensures that the biosynthetic machinery to form new septa is in place before the machinery to degrade septated daughter cells is enabled. β-lactams that target FtsI subvert this mechanism by inhibiting FtsI without perturbing the normal assembly of the cell division machinery and the consequent activation of cell wall hydrolases. One seemingly paradoxical implication of our results is that β-lactam therapy may be improved by promoting active cell division.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2217673120", "doi": "10.1073/pnas.2217673120", "title": "Gaucher disease protects against tuberculosis", "publicationYear": 2023, "publicationDate": "2023-02-14", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "120", "issue": "7", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Jingwen Fan, Victoria L. Hale, Lindsey T. Lelieveld, Laura J. Whitworth, Elisabeth M. Busch-Nentwich, Mark Troll, Paul H. Edelstein, Timothy M. Cox, Francisco J. Roca, Johannes M. F. G. Aerts, Lalita Ramakrishnan", "authorCount": 11, "firstAuthorAffiliation": "Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, UK", "isReferencedByCount": 21, "referenceCount": 71, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Wellcome Trust, HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NWO | Nationaal Regieorgaan Onderwijsonderzoek, NIHR | NIHR Cambridge Biomedical Research Centre", "funderIds": "10.13039/100010269, 10.13039/100015691, 10.13039/501100010071, 10.13039/501100018956", "url": "https://doi.org/10.1073/pnas.2217673120", "pdfUrl": null, "abstract": "Biallelic mutations in the glucocerebrosidase ( GBA1 ) gene cause Gaucher disease, characterized by lysosomal accumulation of glucosylceramide and glucosylsphingosine in macrophages. Gaucher and other lysosomal diseases occur with high frequency in Ashkenazi Jews. It has been proposed that the underlying mutations confer a selective advantage, in particular conferring protection against tuberculosis. Here, using a zebrafish Gaucher disease model, we find that the mutation GBA1 N370S, predominant among Ashkenazi Jews, increases resistance to tuberculosis through the microbicidal activity of glucosylsphingosine in macrophage lysosomes. Consistent with lysosomal accumulation occurring only in homozygotes, heterozygotes remain susceptible to tuberculosis. Thus, our findings reveal a mechanistic basis for protection against tuberculosis by GBA1 N370S and provide biological plausibility for its selection if the relatively mild deleterious effects in homozygotes were offset by significant protection against tuberculosis, a rampant killer of the young in Europe through the Middle Ages into the 19th century.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2204752119", "doi": "10.1073/pnas.2204752119", "title": "TPL2 kinase expression is regulated by the p38γ/p38δ-dependent association of aconitase-1 with <i>TPL2</i> mRNA", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "119", "issue": "35", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Alejandra Escós, José Martín-Gómez, Diego González-Romero, Ester Díaz-Mora, Rosario Francisco-Velilla, Cesar Santiago, José M. Cuezva, Sonia Domínguez-Zorita, Encarnación Martínez-Salas, Nahum Sonenberg, Juan José Sanz-Ezquerro, Seyed Mehdi Jafarnejad, Ana Cuenda", "authorCount": 13, "firstAuthorAffiliation": "Department of Immunology and Oncology, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB/CSIC) Campus Universidad Autónoma de Madrid (UAM), Madrid, 28049 Spain", "isReferencedByCount": 8, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "Ministerio de Ciencia e Innovaci&#x00F3;n, Ministerio de Ciencia e Innovaci&#x00F3;n, Ministerio de Ciencia e Innovaci&#x00F3;n", "funderIds": "10.13039/501100004837, 10.13039/501100004837, 10.13039/501100004837", "url": "https://doi.org/10.1073/pnas.2204752119", "pdfUrl": null, "abstract": "p38γ and p38δ (p38γ/p38δ) regulate inflammation, in part by controlling tumor progression locus 2 (TPL2) expression in myeloid cells. Here, we demonstrate that TPL2 protein levels are dramatically reduced in p38γ/p38δ-deficient (p38γ/δ −/− ) cells and tissues without affecting TPL2 messenger ribonucleic acid (mRNA) expression. We show that p38γ/p38δ posttranscriptionally regulates the TPL2 amount at two different levels. p38γ/p38δ interacts with the TPL2/A20 Binding Inhibitor of NF-κB2 (ABIN2)/Nuclear Factor κB1p105 (NF-κB1p105) complex, increasing TPL2 protein stability. Additionally, p38γ/p38δ regulates TPL2 mRNA translation by modulating the repressor function of TPL2 3′ Untranslated region (UTR) mediated by its association with aconitase-1 (ACO1). ACO1 overexpression in wild-type cells increases the translational repression induced by TPL2 3′UTR and severely decreases TPL2 protein levels. p38δ binds to ACO1, and p38δ expression in p38γ/δ −/− cells fully restores TPL2 protein to wild-type levels by reducing the translational repression of TPL2 mRNA. This study reveals a unique mechanism of posttranscriptional regulation of TPL2 expression, which given its central role in innate immune response, likely has great relevance in physiopathology.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.95.26.15464", "doi": "10.1073/pnas.95.26.15464", "title": "A new Eocene archaeocete (Mammalia, Cetacea) from India and the time of origin of whales", "publicationYear": 1998, "publicationDate": "1998-12-22", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "95", "issue": "26", "page": "15464-15468", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Sunil Bajpai, Philip D. Gingerich", "authorCount": 2, "firstAuthorAffiliation": "Department of Earth Sciences, University of Roorkee, Roorkee 247667, Uttar Pradesh, India; and Museum of Paleontology and Department of Geological Sciences, University of Michigan, Ann Arbor, MI 48019-1079", "isReferencedByCount": 117, "referenceCount": 31, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.95.26.15464", "pdfUrl": null, "abstract": "Himalayacetus subathuensis is a new pakicetid archaeocete from the Subathu Formation of northern India. The type dentary has a small mandibular canal indicating a lack of auditory specializations seen in more advanced cetaceans, and it has Pakicetus -like molar teeth suggesting that it fed on fish. Himalayacetus is significant because it is the oldest archaeocete known and because it was found in marine strata associated with a marine fauna. Himalayacetus extends the fossil record of whales about 3.5 million years back in geological time, to the middle part of the early Eocene [≈53.5 million years ago (Ma)]. Oxygen in the tooth-enamel phosphate has an isotopic composition intermediate between values reported for freshwater and marine archaeocetes, indicating that Himalayacetus probably spent some time in both environments. When the temporal range of Archaeoceti is calibrated radiometrically, comparison of likelihoods constrains the time of origin of Archaeoceti and hence Cetacea to about 54–55 Ma (beginning of the Eocene), whereas their divergence from extant Artiodactyla may have been as early as 64–65 Ma (beginning of the Cenozoic).", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1819154116", "doi": "10.1073/pnas.1819154116", "title": "<i>Klebsiella oxytoca</i> enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities", "publicationYear": 2019, "publicationDate": "2019-02-26", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "116", "issue": "9", "page": "3774-3783", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Katrin Unterhauser, Lisa Pöltl, Georg Schneditz, Sabine Kienesberger, Ronald A. Glabonjat, Maksym Kitsera, Jakob Pletz, Fernando Josa-Prado, Elisabeth Dornisch, Christian Lembacher-Fadum, Sandro Roier, Gregor Gorkiewicz, Daniel Lucena, Isabel Barasoain, Wolfgang Kroutil, Marc Wiedner, Joanna I. Loizou, Rolf Breinbauer, José Fernando Díaz, Stefan Schild, Christoph Högenauer, Ellen L. Zechner", "authorCount": 22, "firstAuthorAffiliation": "Institute of Molecular Biosciences, University of Graz, A-8010 Graz, Austria;", "isReferencedByCount": 77, "referenceCount": 58, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "Austrian Science Fund, BioTechMed-Graz, Ministerio de Economica y Competitividad, BioTechMed-Graz", "funderIds": "10.13039/501100002428", "url": "https://doi.org/10.1073/pnas.1819154116", "pdfUrl": null, "abstract": "Significance Human gut microbes form a complex community with vast biosynthetic potential. Microbial products and metabolites released in the gut impact human health and disease. However, defining causative relationships between specific bacterial products and disease initiation and progression remains an immense challenge. This study advances understanding of the functional capacity of the gut microbiota by determining the presence, concentration, and spatial and temporal variability of two enterotoxic metabolites produced by the gut-resident Klebsiella oxytoca . We present a detailed mode of action for the cytotoxins and recapitulate their functionalities in disease models in vivo. The findings provide distinct molecular mechanisms for the enterotoxicity of the metabolites allowing them to act in tandem to damage the intestinal epithelium and cause colitis.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.0900701106", "doi": "10.1073/pnas.0900701106", "title": "Ecological modulation of plant defense via phytochrome control of jasmonate sensitivity", "publicationYear": 2009, "publicationDate": "2009-03-24", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "106", "issue": "12", "page": "4935-4940", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Javier E. Moreno, Yi Tao, Joanne Chory, Carlos L. Ballaré", "authorCount": 4, "firstAuthorAffiliation": "Ifeva, Consejo Nacional de Investigaciones Científicas y Técnicas, and Universidad de Buenos Aires, Avenida San Martín 4453 C1417DSE Buenos Aires, Argentina; and", "isReferencedByCount": 251, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.0900701106", "pdfUrl": null, "abstract": "For plants, the tradeoff between resource investment in defense and increased growth to out-compete neighbors creates an allocation dilemma. How plants resolve this dilemma, at the mechanistic level, is unclear. We found that Arabidopsis plants produced an attenuated defense phenotype under conditions of crowding and when exposed to far-red (FR) radiation, a light signal that plants use to detect the proximity of neighbors via the photoreceptor phytochrome. This phenotype was detectable through standard bioassays that measured the growth of Spodoptera frugiperda caterpillars. Two possible explanations for the effect of FR are: ( i ) a simple by-product of the diversion of resources to competition, and ( ii ) a specific effect of phytochrome on defense signaling. The first possibility was ruled out by the fact that the auxin-deficient sav3 mutant, which fails to induce growth responses to FR, still responded to FR with an attenuated defense phenotype. In support of the second hypothesis, we found that phytochrome inactivation by FR caused a strong reduction of plant sensitivity to jasmonates, which are key regulators of plant immunity. The effects of FR on jasmonate sensitivity were restricted to certain elements of the pathway. Supporting the idea that the FR effects on jasmonate signaling are functionally significant, we found that FR failed to increase tissue quality in jar1 , a mutant impaired in jasmonate response. We conclude that the plant modulates its investment in defense as a function of the perceived risk of competition, and that this modulation is effected by phytochrome via selective desensitization to jasmonates.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1819440116", "doi": "10.1073/pnas.1819440116", "title": "Genetic and molecular analysis of trichome development in <i>Arabis alpina</i>", "publicationYear": 2019, "publicationDate": "2019-06-11", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "116", "issue": "24", "page": "12078-12083", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Divykriti Chopra, Mona Mapar, Lisa Stephan, Maria C. Albani, Anna Deneer, George Coupland, Eva-Maria Willing, Swen Schellmann, Korbinian Schneeberger, Christian Fleck, Andrea Schrader, Martin Hülskamp", "authorCount": 12, "firstAuthorAffiliation": "Botanical Institute, Biocenter, University of Cologne, 50674 Cologne, Germany;", "isReferencedByCount": 33, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": "https://www.pnas.org/site/aboutpnas/licenses.xhtml", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.1819440116", "pdfUrl": null, "abstract": "Significance Typically, comparative developmental studies focus on the question whether key genes are conserved over large evolutionary distances. How the gene regulatory network of a whole developmental process evolves is virtually unknown. This requires a functional comparison of homologous processes in species closely related enough to find similarities and distant enough to see functional changes. We approach this question by genetically and molecularly comparing trichome development in Arabidopsis thaliana with that in Arabis alpina . We show which steps are regulated similarly and which are different. A closer analysis of trichome patterning revealed fascinating changes in the gene regulatory network; in particular, the finding that overexpression of one key regulator leads to opposite phenotypes in the two species suggested fundamental changes.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.0711731105", "doi": "10.1073/pnas.0711731105", "title": "Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation", "publicationYear": 2008, "publicationDate": "2008-04", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "105", "issue": "13", "page": "5099-5104", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Wolfgang Hoyer, Caroline Grönwall, Andreas Jonsson, Stefan Ståhl, Torleif Härd", "authorCount": 5, "firstAuthorAffiliation": "*Department of Medical Biochemistry and Swedish Nuclear Magnetic Resonance Center, University of Gothenburg, Box 440, SE-405 30 Göteborg, Sweden;", "isReferencedByCount": 388, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.0711731105", "pdfUrl": null, "abstract": "According to the amyloid hypothesis, the pathogenesis of Alzheimer's disease is triggered by the oligomerization and aggregation of the amyloid-β (Aβ) peptide into protein plaques. Formation of the potentially toxic oligomeric and fibrillar Aβ assemblies is accompanied by a conformational change toward a high content of β-structure. Here, we report the solution structure of Aβ(1–40) in complex with the phage-display selected affibody protein Z Aβ3 , a binding protein of nanomolar affinity. Bound Aβ(1–40) features a β-hairpin comprising residues 17–36, providing the first high-resolution structure of Aβ in β conformation. The positions of the secondary structure elements strongly resemble those observed for fibrillar Aβ. Z Aβ3 stabilizes the β-sheet by extending it intermolecularly and by burying both of the mostly nonpolar faces of the Aβ hairpin within a large hydrophobic tunnel-like cavity. Consequently, Z Aβ3 acts as a stoichiometric inhibitor of Aβ fibrillation. The selected Aβ conformation allows us to suggest a structural mechanism for amyloid formation based on soluble oligomeric hairpin intermediates.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1632821100", "doi": "10.1073/pnas.1632821100", "title": "A chemical approach for identifying <i>O</i> -GlcNAc-modified proteins in cells", "publicationYear": 2003, "publicationDate": "2003-08-05", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "100", "issue": "16", "page": "9116-9121", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "David J. Vocadlo, Howard C. Hang, Eun-Ju Kim, John A. Hanover, Carolyn R. Bertozzi", "authorCount": 5, "firstAuthorAffiliation": "Center for New Directions in Organic Synthesis,\r Department of Chemistry, and Department of\r Molecular and Cell Biology, Material Sciences Division, Lawrence Berkeley\r National Laboratory, and Howard Hughes Medical Institute, University of\r California, Berkeley, CA 94720; and Laboratory\r of Biochemistry and Metabolism, National Institute of Diabetes and Digestive\r and Kidney Diseases, National Institutes of Health, Bethesda, MD\r 20892-0851", "isReferencedByCount": 509, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.1632821100", "pdfUrl": null, "abstract": "The glycosylation of serine and threonine residues with a single GlcNAc moiety is a dynamic posttranslational modification of many nuclear and cytoplasmic proteins. We describe a chemical strategy directed toward identifying O -GlcNAc-modified proteins from living cells or proteins modified in vitro . We demonstrate, in vitro , that each enzyme in the hexosamine salvage pathway, and the enzymes that affect this dynamic modification (UDP-GlcNAc:polypeptidtyltransferase and O -GlcNAcase), tolerate analogues of their natural substrates in which the N -acyl side chain has been modified to bear a bio-orthogonal azide moiety. Accordingly, treatment of cells with N -azidoacetylglucosamine results in the metabolic incorporation of the azido sugar into nuclear and cytoplasmic proteins. These O -azidoacetylglucosamine-modified proteins can be covalently derivatized with various biochemical probes at the site of protein glycosylation by using the Staudinger ligation. The approach was validated by metabolic labeling of nuclear pore protein p62, which is known to be posttranslationally modified with O -GlcNAc. This strategy will prove useful for both the identification of O -GlcNAc-modified proteins and the elucidation of the specific residues that bear this saccharide.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2512430122", "doi": "10.1073/pnas.2512430122", "title": "Cryo-EM structure of the prohibitin complex in open conformation", "publicationYear": 2025, "publicationDate": "2025-09-23", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "122", "issue": "38", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Sixing Hong, Zeyuan Guan, Liying Zhang, Jinjin Zhuang, Ling Yan, Yanjun Liu, Zhu Liu, Qiang Wang, Ping Yin", "authorCount": 9, "firstAuthorAffiliation": "National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University", "isReferencedByCount": 11, "referenceCount": 56, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.2512430122", "pdfUrl": null, "abstract": "Prohibitin 1 (PHB1) and Prohibitin 2 (PHB2), two conserved prohibitin members, are primarily localized to the mitochondrial inner membrane (MIM) to form a nanoscale macromolecular prohibitin complex. This prohibitin complex can facilitate the spatial organization of proteins and lipids, thus maintaining cellular metabolism and homeostasis, but its architecture remains largely unknown. Here, we report the cryo-EM structure of a prohibitin complex at 2.8 Å resolution, which contains 11 PHB1–PHB2 heterodimers. This complex displays a bell-like cage, consisting of a lid and a wall, which creates an intermembrane space-facing compartment for the MIM. The lid of the cage is stably assembled, and it is responsible for the prohibitin complex formation. In contrast, the wall of the cage is flexible and exhibits lateral openings, providing a channel for intramembrane exchange of proteins and lipids. These findings provide a structural basis for understanding the scaffold role of the prohibitin complex in organizing intramembrane proteins and lipids.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2107771118", "doi": "10.1073/pnas.2107771118", "title": "Eicosanoid regulation of debris-stimulated metastasis", "publicationYear": 2021, "publicationDate": "2021-10-12", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "118", "issue": "41", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Jianjun Deng, Haixia Yang, Victoria M. Haak, Jun Yang, Franciele C. Kipper, Chantal Barksdale, Sung Hee Hwang, Allison Gartung, Diane R. Bielenberg, Selvakumar Subbian, Koc-Kan Ho, Xiang Ye, Daidi Fan, Yongkui Sun, Bruce D. Hammock, Dipak Panigrahy", "authorCount": 16, "firstAuthorAffiliation": "Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;", "isReferencedByCount": 24, "referenceCount": 140, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "HHS | NIH | National Institute of Environmental Health Sciences, HHS | NIH | National Institute of Environmental Health Sciences, Credit Unions Kids at Heart, Joe Andruzzi Foundation, CJ Buckley Pediatric Brain Tumor Fund", "funderIds": "10.13039/100000066, 10.13039/100000066, 10.13039/100007267", "url": "https://doi.org/10.1073/pnas.2107771118", "pdfUrl": null, "abstract": "Significance Cancer therapy, such as chemotherapy, induces tumor cell death (“debris”), which can stimulate metastasis. Chemotherapy-generated debris upregulates soluble epoxide hydrolase (sEH) and the prostaglandin E 2 receptor 4 (EP4), which triggers a macrophage-derived storm of proinflammatory and proangiogenic lipid autacoid and cytokine mediators. Although sEH inhibitors and EP4 antagonists are in clinical development for multiple inflammatory diseases, their combined role in cancer is unknown. Here, we show that the synergistic antitumor activity of sEH and EP4 inhibition suppresses hepato-pancreatic tumor growth, without overt toxicity, via macrophage phagocytosis of debris and counterregulation of a debris-stimulated cytokine storm. Thus, stimulating the resolution of inflammation via combined inhibition of sEH and EP4 may be an approach for preventing metastatic progression driven by cancer therapy.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2114244118", "doi": "10.1073/pnas.2114244118", "title": "Therapeutic IGF-I receptor inhibition alters fibrocyte immune phenotype in thyroid-associated ophthalmopathy", "publicationYear": 2021, "publicationDate": "2021-12-28", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "118", "issue": "52", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Roshini Fernando, Oshadi Caldera, Terry J. Smith", "authorCount": 3, "firstAuthorAffiliation": "Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105", "isReferencedByCount": 44, "referenceCount": 84, "isOpenAccess": true, "licenseUrl": "https://www.pnas.org/site/aboutpnas/licenses.xhtml", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.2114244118", "pdfUrl": null, "abstract": "Significance Teprotumumab, a therapeutic IGF-I receptor inhibitor, dramatically alters the clinical course of thyroid-associated ophthalmopathy (TAO) and has recently become the only medical therapy for TAO thus far approved by the US FDA. Introduction of teprotumumab has resulted in a paradigm shift in the clinical management of TAO. Here, we demonstrate that teprotumumab and other IGF-I inhibitors attenuate MHC II and B7 expression in fibrocytes in TAO, both in vitro and in patients treated with the drug in vivo. This inhibition is associated with substantial reductions in two key inflammatory cytokines implicated in TAO. Thus, the current findings provide a plausible mechanism underlying the therapeutic responses to teprotumumab.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1714977115", "doi": "10.1073/pnas.1714977115", "title": "Phylogenetic classification of the world’s tropical forests", "publicationYear": 2018, "publicationDate": "2018-02-20", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "115", "issue": "8", "page": "1837-1842", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "J. W. Ferry Slik, Janet Franklin, Víctor Arroyo-Rodríguez, Richard Field, Salomon Aguilar, Nikolay Aguirre, Jorge Ahumada, Shin-Ichiro Aiba, Luciana F. Alves, Anitha K, Andres Avella, Francisco Mora, Gerardo A. Aymard C., Selene Báez, Patricia Balvanera, Meredith L. Bastian, Jean-François Bastin, Peter J. Bellingham, Eduardo van den Berg, Polyanna da Conceição Bispo, Pascal Boeckx, Katrin Boehning-Gaese, Frans Bongers, Brad Boyle, Fabian Brambach, Francis Q. Brearley, Sandra Brown, Shauna-Lee Chai, Robin L. Chazdon, Shengbin Chen, Phourin Chhang, George Chuyong, Corneille Ewango, Indiana M. Coronado, Jurgi Cristóbal-Azkarate, Heike Culmsee, Kipiro Damas, H. S. Dattaraja, Priya Davidar, Saara J. DeWalt, Hazimah Din, Donald R. Drake, Alvaro Duque, Giselda Durigan, Karl Eichhorn, Eduardo Schmidt Eler, Tsutomu Enoki, Andreas Ensslin, Adandé Belarmain Fandohan, Nina Farwig, Kenneth J. Feeley, Markus Fischer, Olle Forshed, Queila Souza Garcia, Satish Chandra Garkoti, Thomas W. Gillespie, Jean-Francois Gillet, Christelle Gonmadje, Iñigo Granzow-de la Cerda, Daniel M. Griffith, James Grogan, Khalid Rehman Hakeem, David J. Harris, Rhett D. Harrison, Andy Hector, Andreas Hemp, Jürgen Homeier, M. Shah Hussain, Guillermo Ibarra-Manríquez, I. Faridah Hanum, Nobuo Imai, Patrick A. Jansen, Carlos Alfredo Joly, Shijo Joseph, Kuswata Kartawinata, Elizabeth Kearsley, Daniel L. Kelly, Michael Kessler, Timothy J. Killeen, Robert M. Kooyman, Yves Laumonier, Susan G. Laurance, William F. Laurance, Michael J. Lawes, Susan G. Letcher, Jeremy Lindsell, Jon Lovett, Jose Lozada, Xinghui Lu, Anne Mette Lykke, Khairil Bin Mahmud, Ni Putu Diana Mahayani, Asyraf Mansor, Andrew R. Marshall, Emanuel H. Martin, Darley Calderado Leal Matos, Jorge A. Meave, Felipe P. L. Melo, Zhofre Huberto Aguirre Mendoza, Faizah Metali, Vincent P. Medjibe, Jean Paul Metzger, Thiago Metzker, D. Mohandass, Miguel A. Munguía-Rosas, Rodrigo Muñoz, Eddy Nurtjahy, Eddie Lenza de Oliveira, Onrizal, Pia Parolin, Marc Parren, N. Parthasarathy, Ekananda Paudel, Rolando Perez, Eduardo A. Pérez-García, Ulf Pommer, Lourens Poorter, Lan Qie, Maria Teresa F. Piedade, José Roberto Rodrigues Pinto, Axel Dalberg Poulsen, John R. Poulsen, Jennifer S. Powers, Rama Chandra Prasad, Jean-Philippe Puyravaud, Orlando Rangel, Jan Reitsma, Diogo S. B. Rocha, Samir Rolim, Francesco Rovero, Andes Rozak, Kalle Ruokolainen, Ervan Rutishauser, Gemma Rutten, Mohd. Nizam Mohd. Said, Felipe Z. Saiter, Philippe Saner, Braulio Santos, João Roberto dos Santos, Swapan Kumar Sarker, Christine B. Schmitt, Jochen Schoengart, Mark Schulze, Douglas Sheil, Plinio Sist, Alexandre F. Souza, Wilson Roberto Spironello, Tereza Sposito, Robert Steinmetz, Tariq Stevart, Marcio Seiji Suganuma, Rahayu Sukri, Aisha Sultana, Raman Sukumar, Terry Sunderland, Supriyadi, H. S. Suresh, Eizi Suzuki, Marcelo Tabarelli, Jianwei Tang, Ed V. J. Tanner, Natalia Targhetta, Ida Theilade, Duncan Thomas, Jonathan Timberlake, Márcio de Morisson Valeriano, Johan van Valkenburg, Tran Van Do, Hoang Van Sam, John H. Vandermeer, Hans Verbeeck, Ole Reidar Vetaas, Victor Adekunle, Simone A. Vieira, Campbell O. Webb, Edward L. Webb, Timothy Whitfeld, Serge Wich, John Williams, Susan Wiser, Florian Wittmann, Xiaobo Yang, C. Yves Adou Yao, Sandra L. Yap, Rakan A. Zahawi, Rahmad Zakaria, Runguo Zang", "authorCount": 187, "firstAuthorAffiliation": "Environmental and Life Sciences, Faculty of Science, Universiti Brunei Darussalam, Gadong BE1410, Brunei Darussalam;", "isReferencedByCount": 132, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.1714977115", "pdfUrl": null, "abstract": "Significance Identifying and explaining regional differences in tropical forest dynamics, structure, diversity, and composition are critical for anticipating region-specific responses to global environmental change. Floristic classifications are of fundamental importance for these efforts. Here we provide a global tropical forest classification that is explicitly based on community evolutionary similarity, resulting in identification of five major tropical forest regions and their relationships: ( i ) Indo-Pacific, ( ii ) Subtropical, ( iii ) African, ( iv ) American, and ( v ) Dry forests. African and American forests are grouped, reflecting their former western Gondwanan connection, while Indo-Pacific forests range from eastern Africa and Madagascar to Australia and the Pacific. The connection between northern-hemisphere Asian and American forests is confirmed, while Dry forests are identified as a single tropical biome.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1522297113", "doi": "10.1073/pnas.1522297113", "title": "Chromatographically isolated CD63 <sup>+</sup> CD81 <sup>+</sup> extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI", "publicationYear": 2016, "publicationDate": "2016-01-05", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "113", "issue": "1", "page": "170-175", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Dong-ki Kim, Hidetaka Nishida, Su Yeon An, Ashok K. Shetty, Thomas J. Bartosh, Darwin J. Prockop", "authorCount": 6, "firstAuthorAffiliation": "Institute for Regenerative Medicine at Scott &amp; White, College of Medicine, Texas A&amp;M Health Science Center, Temple, TX 76502", "isReferencedByCount": 401, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.1522297113", "pdfUrl": null, "abstract": "Significance It has gradually been recognized that the vesicles secreted by cells are a major means by which cells communicate with each other. This recognition has stimulated interest in using vesicles to deliver therapeutic agents. The results presented here address several limitations to progress in the field by developing protocols to produce and isolate large numbers of extracellular vesicles (EVs) from stem-like cells found in the bone marrow. The isolated EVs were found to reduce the adverse effects of traumatic injury to the brain in mice.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2406308121", "doi": "10.1073/pnas.2406308121", "title": "Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington’s disease", "publicationYear": 2024, "publicationDate": "2024-09-24", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "121", "issue": "39", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Anirban Chakraborty, Sravan Gopalkrishnashetty Sreenivasmurthy, Wyatt Miller, Weihan Huai, Tapan Biswas, Santi Mohan Mandal, Lisardo Boscá, Balaji Krishnan, Gourisankar Ghosh, Tapas Hazra", "authorCount": 10, "firstAuthorAffiliation": "Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555", "isReferencedByCount": 11, "referenceCount": 48, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "HHS | NIH | National Institute of Neurological Disorders and Stroke, HHS | NIH | National Institute of Neurological Disorders and Stroke", "funderIds": "10.13039/100000065, 10.13039/100000065", "url": "https://doi.org/10.1073/pnas.2406308121", "pdfUrl": null, "abstract": "Huntington’s disease (HD) and spinocerebellar ataxia type 3 (SCA3) are the two most prevalent polyglutamine (polyQ) neurodegenerative diseases, caused by CAG (encoding glutamine) repeat expansion in the coding region of the huntingtin (HTT) and ataxin-3 (ATXN3) proteins, respectively. We have earlier reported that the activity, but not the protein level, of an essential DNA repair enzyme, polynucleotide kinase 3′-phosphatase (PNKP), is severely abrogated in both HD and SCA3 resulting in accumulation of double-strand breaks in patients’ brain genome. While investigating the mechanistic basis for the loss of PNKP activity and accumulation of DNA double-strand breaks leading to neuronal death, we observed that PNKP interacts with the nuclear isoform of 6-phosphofructo-2-kinase fructose-2,6-bisphosphatase 3 (PFKFB3). Depletion of PFKFB3 markedly abrogates PNKP activity without changing its protein level. Notably, the levels of both PFKFB3 and its product fructose-2,6 bisphosphate (F2,6BP), an allosteric modulator of glycolysis, are significantly lower in the nuclear extracts of postmortem brain tissues of HD and SCA3 patients. Supplementation of F2,6BP restored PNKP activity in the nuclear extracts of patients’ brain. Moreover, intracellular delivery of F2,6BP restored both the activity of PNKP and the integrity of transcribed genome in neuronal cells derived from the striatum of the HD mouse. Importantly, supplementing F2,6BP rescued the HD phenotype in Drosophila, suggesting F2,6BP to serve in vivo as a cofactor for the proper functionality of PNKP and thereby, of brain health. Our results thus provide a compelling rationale for exploring the therapeutic use of F2,6BP and structurally related compounds for treating polyQ diseases.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.0603694103", "doi": "10.1073/pnas.0603694103", "title": "Human methionine synthase reductase is a molecular chaperone for human methionine synthase", "publicationYear": 2006, "publicationDate": "2006-06-20", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "103", "issue": "25", "page": "9476-9481", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Kazuhiro Yamada, Roy A. Gravel, Tetsuo Toraya, Rowena G. Matthews", "authorCount": 4, "firstAuthorAffiliation": "*Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109-2216;", "isReferencedByCount": 104, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.0603694103", "pdfUrl": null, "abstract": "Sustained activity of mammalian methionine synthase (MS) requires MS reductase (MSR), but there have been few studies of the interactions between these two proteins. In this study, recombinant human MS (hMS) and MSR (hMSR) were expressed in baculovirus-infected insect cells and purified to homogeneity. hMSR maintained hMS activity at a 1:1 stoichiometric ratio with a K act value of 71 nM. Escherichia coli MS, however, was not activated by hMSR. Moreover, hMS was not significantly active in the presence of E. coli flavodoxin and flavodoxin reductase, which maintain the activity of E. coli MS. These results indicate that recognition of MS by their reductive partners is very strict, despite the high homology between MS from different species. The effects of hMSR on the formation of hMS holoenzyme also were examined by using crude extracts of baculovirus-infected insect cells containing hMS apoenzyme (apoMS). In the presence of MSR and NADPH, holoenzyme formation from apoMS and methylcobalamin was significantly enhanced. The observed stimulation is shown to be due to stabilization of human apoMS in the presence of MSR. Apoenzyme alone is quite unstable at 37°C. MSR also is able to reduce aquacobalamin to cob(II)alamin in the presence of NADPH, and this reduction leads to stimulation of the conversion of apoMS and aquacobalamin to MS holoenzyme. Based on these findings, we propose that MSR serves as a special chaperone for hMS and as an aquacobalamin reductase, rather than acting solely in the reductive activation of MS.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.92.10.4427", "doi": "10.1073/pnas.92.10.4427", "title": "Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit.", "publicationYear": 1995, "publicationDate": "1995-05-09", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "92", "issue": "10", "page": "4427-4431", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "T Helaakoski, P Annunen, K Vuori, I A MacNeil, T Pihlajaniemi, K I Kivirikko", "authorCount": 6, "firstAuthorAffiliation": "Collagen Research Unit, University of Oulu, Finland.", "isReferencedByCount": 91, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.92.10.4427", "pdfUrl": null, "abstract": "Prolyl 4-hydroxylase (EC 1.14.11.2) catalyzes the posttranslational formation of 4-hydroxyproline in collagens. The vertebrate enzyme is an alpha 2 beta 2 tetramer, the beta subunit of which is a highly unusual multifunctional polypeptide, being identical to protein disulfide-isomerase (EC 5.3.4.1). We report here the cloning of a second mouse alpha subunit isoform, termed the alpha (II) subunit. This polypeptide consists of 518 aa and a signal peptide of 19 aa. The processed polypeptide is one residue longer than the mouse alpha (I) subunit (the previously known type), the cloning of which is also reported here. The overall amino acid sequence identity between the mouse alpha (II) and alpha (I) subunits is 63%. The mRNA for the alpha (II) subunit was found to be expressed in a variety of mouse tissues. When the alpha (II) subunit was expressed together with the human protein disulfide-isomerase/beta subunit in insect cells by baculovirus vectors, an active prolyl 4-hydroxylase was formed, and this protein appeared to be an alpha (II) 2 beta 2 tetramer. The activity of this enzyme was very similar to that of the human alpha (I) 2 beta 2 tetramer, and most of its catalytic properties were also highly similar, but it differed distinctly from the latter in that it was inhibited by poly(L-proline) only at very high concentrations. This property may explain why the type II enzyme was not recognized earlier, as an early step in the standard purification procedure for prolyl 4-hydroxylase is affinity chromatography on a poly(L-proline) column.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1815427116", "doi": "10.1073/pnas.1815427116", "title": "Coupling between dynamic 3D tissue architecture and BMP morphogen signaling during <i>Drosophila</i> wing morphogenesis", "publicationYear": 2019, "publicationDate": "2019-03-05", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "116", "issue": "10", "page": "4352-4361", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Jinghua Gui, Yunxian Huang, Martin Montanari, Daniel Toddie-Moore, Kenji Kikushima, Stephanie Nix, Yukitaka Ishimoto, Osamu Shimmi", "authorCount": 8, "firstAuthorAffiliation": "Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland;", "isReferencedByCount": 15, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "Suomen Akatemia, Suomen Akatemia, Suomen Akatemia, Suomen Akatemia, Sigrid Juséliuksen Säätiö, MEXT | Japan Society for the Promotion of Science, MEXT | Japan Society for the Promotion of Science, Finnish Cultural Foundation | Etelä-Karjalan Rahasto, University of Helsinki | Helsingin Yliopiston Tiedesäätiö", "funderIds": "10.13039/501100002341, 10.13039/501100002341, 10.13039/501100002341, 10.13039/501100002341, 10.13039/501100006306, 10.13039/501100001691, 10.13039/501100001691, 10.13039/501100005428, 10.13039/100007798", "url": "https://doi.org/10.1073/pnas.1815427116", "pdfUrl": null, "abstract": "Significance Tissue morphogenesis is a dynamic process often accompanied by cell patterning and differentiation. Although how conserved growth factor signaling affects cell and tissue shapes has been actively studied, much less is known about how signaling and dynamic morphogenesis are mutually coordinated. Our study shows that BMP signaling and 3D morphogenesis of the Drosophila pupal wing are tightly coupled. These findings are highlighted by the fact that the directionality of BMP signal is changed from lateral planar during the inflation stage to interplanar after re-apposition of the dorsal and ventral wing epithelia. We suspect that the dynamic interplay between planar and interplanar signaling linked to tissue shape changes is likely to be used across species in many developing organs.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1802188115", "doi": "10.1073/pnas.1802188115", "title": "Glycosylation-dependent galectin–receptor interactions promote <i>Chlamydia trachomatis</i> infection", "publicationYear": 2018, "publicationDate": "2018-06-26", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "115", "issue": "26", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Agustin L. Lujan, Diego O. Croci, Julián A. Gambarte Tudela, Antonella D. Losinno, Alejandro J. Cagnoni, Karina V. Mariño, María T. Damiani, Gabriel A. Rabinovich", "authorCount": 8, "firstAuthorAffiliation": "Laboratorio de Fagocitosis, Instituto de Histología y Embriología de Mendoza, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, C5500 Mendoza, Argentina;", "isReferencedByCount": 43, "referenceCount": 59, "isOpenAccess": true, "licenseUrl": "http://www.pnas.org/site/aboutpnas/licenses.xhtml", "funderNames": "MINCyT | Agencia Nacional de Promoción Científica y Tecnológica, MINCyT | Agencia Nacional de Promoción Científica y Tecnológica", "funderIds": "10.13039/501100003074, 10.13039/501100003074", "url": "https://doi.org/10.1073/pnas.1802188115", "pdfUrl": null, "abstract": "Significance Chlamydia trachomatis ( Ct ) is the most common bacterium responsible for sexually transmitted infections. It constitutes a major public health burden, with the greatest clinical impact occurring in women of reproductive age. A vast proportion of Ct infections are underestimated because they are asymptomatic in nature. This leads to chronic infections with severe consequences, such as ectopic pregnancy, tubal obstruction, infertility, and blindness. Ct is an obligate intracellular pathogen that completes its entire developmental cycle in humans. Here, we demonstrate that galectin-1 (Gal1), an endogenous glycan-binding protein, promotes Ct –host adhesion and invasion. Through glycosylation-dependent mechanisms, Gal1 enhances chlamydial infection by favoring Ct –host cell interactions. Thus, novel therapeutic approaches aimed at disrupting Gal1– N -glycan interactions may reduce the severity of Ct infections.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2434175100", "doi": "10.1073/pnas.2434175100", "title": "Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease", "publicationYear": 2003, "publicationDate": "2003-12-09", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "100", "issue": "25", "page": "15119-15124", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Yoshiyuki Ban, David A. Greenberg, Erlinda Concepcion, Lucy Skrabanek, Ronald Villanueva, Yaron Tomer", "authorCount": 6, "firstAuthorAffiliation": "Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, and Institute for Computational Biomedicine, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029; and Division of Statistical Genetics, Columbia University, New York, NY 10032", "isReferencedByCount": 145, "referenceCount": 61, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.2434175100", "pdfUrl": null, "abstract": "The 8q24 locus, which contains the thyroglobulin (Tg) gene, was previously shown to be strongly linked with autoimmune thyroid disease (AITD). We sequenced all 48 exons of the Tg gene and identified 14 single-nucleotide polymorphisms (SNPs). Case control association studies demonstrated that an exon 10-12 SNP cluster and an exon 33 SNP were significantly associated with AITD ( P &lt; 0.01). Haplotype analysis demonstrated that the combination of these two SNP groups was more significantly associated with AITD ( P &lt; 0.001). Gene-gene interaction studies provided evidence for an interaction between HLA-DR3 and the exon 33 SNP, giving an odds ratio of 6.1 for Graves' disease. We then sequenced exons 10,12, and 33 of the mouse Tg gene in 19 strains of mice. Fifty percent of the strains susceptible to thyroiditis had a unique SNP haplotype at exons 10 and 12, whereas none of the mouse strains that were resistant to thyroiditis had this SNP haplotype ( P = 0.01). We concluded that Tg is a susceptibility gene for AITD, both in humans in and in mice. A combination of at least two Tg SNPs conferred susceptibility to human AITD. Moreover, the exon 33 SNP showed evidence for interaction with HLA-DR3 in conferring susceptibility to Graves' disease.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1711408114", "doi": "10.1073/pnas.1711408114", "title": "Dual function for Tango1 in secretion of bulky cargo and in ER-Golgi morphology", "publicationYear": 2017, "publicationDate": "2017-11-28", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "114", "issue": "48", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "L. D. Ríos-Barrera, S. Sigurbjörnsdóttir, M. Baer, M. Leptin", "authorCount": 4, "firstAuthorAffiliation": "Directors' Research Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany;", "isReferencedByCount": 54, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "Deutsche Forschungsgemeinschaft, European Molecular Biology Organization, EMBL Interdisciplinary Postdoctoral Programme, NRW Graduate School for Genetics and Functional Genomics", "funderIds": "10.13039/501100001659, 10.13039/100004410", "url": "https://doi.org/10.1073/pnas.1711408114", "pdfUrl": null, "abstract": "Significance Exporting bulky molecules poses challenges for cells, since the membrane vesicles that transport normal-sized molecules may not be sufficiently large. The protein Tango1 allows transport vesicles to grow much larger to accommodate bulky cargo. It has been puzzling why many smaller cargos also fail to be transported when Tango1 is absent. We show that this is because bulky cargos “clog up” the transport system, resulting in a general traffic jam. Once the blocking, large cargo is removed, the jam resulting from missing Tango1 is resolved, and other cellular stress signals also subside. However, structural defects in the transport system remain, showing that these are due to a direct requirement for Tango1, independent of its function in transport as such.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2206076119", "doi": "10.1073/pnas.2206076119", "title": "Pan-mitogenomics reveals the genetic basis of cytonuclear conflicts in citrus hybridization, domestication, and diversification", "publicationYear": 2022, "publicationDate": "2022-10-25", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "119", "issue": "43", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Nan Wang, Chaochao Li, Lihua Kuang, Xiaomeng Wu, Kaidong Xie, Andan Zhu, Qiang Xu, Robert M. Larkin, Yongfeng Zhou, Xiuxin Deng, Wenwu Guo", "authorCount": 11, "firstAuthorAffiliation": "Key Laboratory of Horticultural Plant Biology (Ministry of Education), Huazhong Agricultural University, Wuhan 430070, China", "isReferencedByCount": 54, "referenceCount": 77, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.2206076119", "pdfUrl": null, "abstract": "Although interactions between the cytoplasmic and nuclear genomes occurred during diversification of many plants, the evolutionary conflicts due to cytonuclear interactions are poorly understood in crop breeding. Here, we constructed a pan-mitogenome and identified chimeric open reading frames (ORFs) generated by extensive structural variations (SVs). Meanwhile, short reads from 184 accessions of citrus species were combined to construct three variation maps for the nuclear, mitochondrial, and chloroplast genomes. The population genomic data showed discordant topologies between the cytoplasmic and nuclear genomes because of differences in mutation rates and levels of heteroplasmy from paternal leakage. An analysis of species-specific SVs indicated that mitochondrial heteroplasmy was common and that chloroplast heteroplasmy was undetectable. Interestingly, we found a prominent divergence in the mitogenomes and the highest genetic load in the, which may provide the basis for cytoplasmic male sterility (CMS) and thus influence the reshuffling of the cytoplasmic and nuclear genomes during hybridization. Using cytoplasmic replacement experiments, we identified a type of species-specific CMS in mandarin related to two chimeric mitochondrial genes. Our analyses indicate that cytoplasmic genomes from mandarin have rarely been maintained in hybrids and that paternal leakage produced very low levels of mitochondrial heteroplasmy in mandarin. A genome-wide association study (GWAS) provided evidence for three nuclear genes that encode pentatricopeptide repeat (PPR) proteins contributing to the cytonuclear interactions in the Citrus genus. Our study demonstrates the occurrence of evolutionary conflicts between cytoplasmic and nuclear genomes in citrus and has important implications for genetics and breeding.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1113931109", "doi": "10.1073/pnas.1113931109", "title": "Climate change, adaptive cycles, and the persistence of foraging economies during the late Pleistocene/Holocene transition in the Levant", "publicationYear": 2012, "publicationDate": "2012-03-06", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "109", "issue": "10", "page": "3640-3645", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Arlene M. Rosen, Isabel Rivera-Collazo", "authorCount": 2, "firstAuthorAffiliation": "Institute of Archaeology, University College London, London WC1H 0PY, United Kingdom; and", "isReferencedByCount": 143, "referenceCount": 57, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.1113931109", "pdfUrl": null, "abstract": "Climatic forcing during the Younger Dryas (∼12.9–11.5 ky B.P.) event has become the theoretical basis to explain the origins of agricultural lifestyles in the Levant by suggesting a failure of foraging societies to adjust. This explanation however, does not fit the scarcity of data for predomestication cultivation in the Natufian Period. The resilience of Younger Dryas foragers is better illustrated by a concept of adaptive cycles within a theory of adaptive change (resilience theory). Such cycles consist of four phases: release/collapse (Ω); reorganization (α), when the system restructures itself after a catastrophic stimulus through innovation and social memory—a period of greater resilience and less vulnerability; exploitation (r); and conservation (K), representing an increasingly rigid system that loses flexibility to change. The Kebarans and Late Natufians had similar responses to cold and dry conditions vs. Early Natufians and the Pre-Pottery Neolithic A responses to warm and wet climates. Kebarans and Late Natufians (α-phase) shifted to a broader-based diet and increased their mobility. Early Natufian and Pre-Pottery Neolithic A populations (r- and K-phases) had a growing investment in more narrowly focused, high-yield plant resources, but they maintained the broad range of hunted animals because of increased sedentism. These human adaptive cycles interlocked with plant and animal cycles. Forest and grassland vegetation responded to late Pleistocene and early Holocene climatic fluctuations, but prey animal cycles reflected the impact of human hunting pressure. The combination of these three adaptive cycles results in a model of human adaptation, showing potential for great sustainability of Levantine foraging systems even under adverse climatic conditions.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.91.17.8219", "doi": "10.1073/pnas.91.17.8219", "title": "Universal signals control slime mold stalk formation.", "publicationYear": 1994, "publicationDate": "1994-08-16", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "91", "issue": "17", "page": "8219-8223", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "S van Es, B W Nieuwenhuijsen, F Lenouvel, E M van Deursen, P Schaap", "authorCount": 5, "firstAuthorAffiliation": "Cell Biology Unit, University of Leiden, The Netherlands.", "isReferencedByCount": 6, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.91.17.8219", "pdfUrl": null, "abstract": "The primitive slime mold Dictyostelium minutum does not display oscillations during aggregation, cannot form migrating slugs, and does not form a prestalk/prespore pattern, all of which are characteristic for development of its advanced relative Dictyostelium discoideum. We used D. minutum to investigate whether slime molds share common mechanisms controlling development. In D. discoideum, the morphogen differentiation inducing factor (DIF) can induce stalk-cell differentiation in vitro. However, stalk formation in vivo is supposedly triggered by local depletion of DIF antagonists such as ammonia or cAMP. A homologue of the D. discoideum stalk gene ecmB was cloned in D. minutum that encodes a 3.4-kb mRNA, and its deduced amino acid sequence shows repeats of 24 amino acids that are characteristic for the D. discoideum ecmB gene. Remarkably, DIF effectively induces expression of the D. minutum ecmB gene and ammonia inhibits its expression. D. discoideum cells were transformed with a construct of the D. minutum ecmB promoter fused to the lacZ reporter gene and showed expression in the stalk, but not in the upper and lower cup of the fruiting body, which also express the D. discoideum ecmB gene. In D. discoideum, the D. minutum ecmB and the ecmB promoter are similarly activated by DIF and repressed by both cAMP and ammonia, suggesting that additional signaling is required for ecmB expression in upper and lower cup cells. Our data indicate that the extracellular signals controlling stalk formation and their intracellular signaling cascades including gene regulatory proteins remained highly conserved during slime mold evolution.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.2221479120", "doi": "10.1073/pnas.2221479120", "title": "The impact of threshold decision mechanisms of collective behavior on disease spread", "publicationYear": 2023, "publicationDate": "2023-05-09", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "120", "issue": "19", "page": null, "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Bryce Morsky, Felicia Magpantay, Troy Day, Erol Akçay", "authorCount": 4, "firstAuthorAffiliation": "Department of Mathematics, Florida State University, Tallahassee, FL 32306", "isReferencedByCount": 49, "referenceCount": 61, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": "Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada, United States - Israel Binational Science Foundation", "funderIds": "10.13039/501100000038, 10.13039/100006221", "url": "https://doi.org/10.1073/pnas.2221479120", "pdfUrl": null, "abstract": "Humans are a hyper-social species, which greatly impacts the spread of infectious diseases. How do social dynamics impact epidemiology and what are the implications for public health policy? Here, we develop a model of disease transmission that incorporates social dynamics and a behavior that reduces the spread of disease, a voluntary nonpharmaceutical intervention (NPI). We use a “tipping-point” dynamic, previously used in the sociological literature, where individuals adopt a behavior given a sufficient prevalence of the behavior in the population. The thresholds at which individuals adopt the NPI behavior are modulated by the perceived risk of infection, i.e., the disease prevalence and transmission rate, costs to adopt the NPI behavior, and the behavior of others. Social conformity creates a type of “stickiness” whereby individuals are resistant to changing their behavior due to the population’s inertia. In this model, we observe a nonmonotonicity in the attack rate as a function of various biological and social parameters such as the transmission rate, efficacy of the NPI, costs of the NPI, weight of social consequences of shirking the social norm, and the degree of heterogeneity in the population. We also observe that the attack rate can be highly sensitive to these parameters due to abrupt shifts in the collective behavior of the population. These results highlight the complex interplay between the dynamics of epidemics and norm-driven collective behaviors.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.90.16.7503", "doi": "10.1073/pnas.90.16.7503", "title": "Triplet structure of von Willebrand factor reflects proteolytic degradation of high molecular weight multimers.", "publicationYear": 1993, "publicationDate": "1993-08-15", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "90", "issue": "16", "page": "7503-7507", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "M Furlan, R Robles, D Affolter, D Meyer, P Baillod, B Lämmle", "authorCount": 6, "firstAuthorAffiliation": "Central Hematology Laboratory, Inselspital, University of Bern, Switzerland.", "isReferencedByCount": 59, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.90.16.7503", "pdfUrl": null, "abstract": "High molecular weight (HMW) and low molecular weight (LMW) forms of von Willebrand factor (vWF) were isolated from normal human plasma in the presence of protease inhibitors. HMW and LMW vWF preparations were subjected to reduction of interdimeric disulfide bridges under mild reducing conditions. Following sodium dodecyl sulfate electrophoresis in 3% agarose, the vWF bands were detected by immunoblotting with a polyclonal rabbit anti-vWF antiserum as well as with two monoclonal antibodies directed against epitopes located in the NH2-terminal (MAb 418) or in the COOH-terminal (MAb 9) region of the vWF subunit. Our results suggest that the slowest migrating band of the dimeric triplet set of LMW vWF represents an asymmetric structure composed of an intact subunit to which one NH2-terminal and one COOH-terminal fragment are linked by disulfide bridges. The intermediate band of the first triplet of LMW vWF strongly reacted with MAb 9 but not with MAb 418, indicating that it represents a dimer of COOH-terminal fragments. The fastest migrating band of the same triplet is apparently a dimer of the NH2-terminal fragments because it reacted with MAb 418 but not with MAb 9. Each next higher family of triplets seems to contain one more asymmetric fragment of dimeric size. These results are compatible with a model according to which LMW forms of vWF are derived from HMW vWF by proteolytic cleavage in the circulating blood.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.0801376105", "doi": "10.1073/pnas.0801376105", "title": "The splicing-factor oncoprotein SF2/ASF activates mTORC1", "publicationYear": 2008, "publicationDate": "2008-10-07", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "105", "issue": "40", "page": "15323-15327", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Rotem Karni, Yoshitaka Hippo, Scott W. Lowe, Adrian R. Krainer", "authorCount": 4, "firstAuthorAffiliation": "*Cold Spring Harbor Laboratory and", "isReferencedByCount": 110, "referenceCount": 28, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.0801376105", "pdfUrl": null, "abstract": "The splicing factor SF2/ASF is an oncoprotein that is up-regulated in many cancers and can transform immortal rodent fibroblasts when slightly overexpressed. The mTOR signaling pathway is activated in many cancers, and pharmacological blockers of this pathway are in clinical trials as anticancer drugs. We examined the activity of the mTOR pathway in cells transformed by SF2/ASF and found that this splicing factor activates the mTORC1 branch of the pathway, as measured by S6K and eIF4EBP1 phosphorylation. This activation is specific to mTORC1 because no activation of Akt, an mTORC2 substrate, was detected. mTORC1 activation by SF2/ASF bypasses upstream PI3K/Akt signaling and is essential for SF2/ASF-mediated transformation, as inhibition of mTOR by rapamycin blocked transformation by SF2/ASF in vitro and in vivo . Moreover, shRNA-mediated knockdown of mTOR, or of the specific mTORC1 and mTORC2 components Raptor and Rictor, abolished the tumorigenic potential of cells overexpressing SF2/ASF. These results suggest that clinical tumors with SF2/ASF up-regulation could be especially sensitive to mTOR inhibitors.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.0904361106", "doi": "10.1073/pnas.0904361106", "title": "Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands", "publicationYear": 2009, "publicationDate": "2009-06-16", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "106", "issue": "24", "page": "9649-9654", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "David A. Zidar, Jonathan D. Violin, Erin J. Whalen, Robert J. Lefkowitz", "authorCount": 4, "firstAuthorAffiliation": "Departments of aMedicine,", "isReferencedByCount": 243, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.0904361106", "pdfUrl": null, "abstract": "CCL19 and CCL21 are endogenous agonists for the seven-transmembrane receptor CCR7. They are equally active in promoting G protein stimulation and chemotaxis. Yet, we find that they result in striking differences in activation of the G protein-coupled receptor kinase (GRK)/ß-arrestin system. CCL19 leads to robust CCR7 phosphorylation and β-arrestin2 recruitment catalyzed by both GRK3 and GRK6 whereas CCL21 activates GRK6 alone. This differential GRK activation leads to distinct functional consequences. Although each ligand leads to β-arrestin2 recruitment, only CCL19 leads to redistribution of β-arrestin2-GFP into endocytic vesicles and classical receptor desensitization. In contrast, these agonists are both capable of signaling through GRK6 and β-arrestin2 to ERK kinases. Thus, this mechanism for “ligand bias” whereby endogenous agonists activate different GRK isoforms leads to functionally distinct pools of β-arrestin.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.0801962105", "doi": "10.1073/pnas.0801962105", "title": "A phylogenetic perspective on the distribution of plant diversity", "publicationYear": 2008, "publicationDate": "2008-08-12", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "105", "issue": "supplement_1", "page": "11549-11555", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Michael J. Donoghue", "authorCount": 1, "firstAuthorAffiliation": "Department of Ecology and Evolutionary Biology and Peabody Museum of Natural History, Yale University, P. O. Box 208106, New Haven, CT 06520-8106", "isReferencedByCount": 611, "referenceCount": 81, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.0801962105", "pdfUrl": null, "abstract": "Phylogenetic studies are revealing that major ecological niches are more conserved through evolutionary history than expected, implying that adaptations to major climate changes have not readily been accomplished in all lineages. Phylogenetic niche conservatism has important consequences for the assembly of both local communities and the regional species pools from which these are drawn. If corridors for movement are available, newly emerging environments will tend to be filled by species that filter in from areas in which the relevant adaptations have already evolved, as opposed to being filled by in situ evolution of these adaptations. Examples include intercontinental disjunctions of tropical plants, the spread of plant lineages around the Northern Hemisphere after the evolution of cold tolerance, and the radiation of northern alpine plants into the Andes. These observations highlight the role of phylogenetic knowledge and historical biogeography in explanations of global biodiversity patterns. They also have implications for the future of biodiversity.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.1201884109", "doi": "10.1073/pnas.1201884109", "title": "Adaptive evolution of voltage-gated sodium channels: The first 800 million years", "publicationYear": 2012, "publicationDate": "2012-06-26", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "109", "issue": "supplement_1", "page": "10619-10625", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Harold H. Zakon", "authorCount": 1, "firstAuthorAffiliation": "Section of Neurobiology, University of Texas, Austin, TX 78712; and Marine Biological Laboratory, The Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Woods Hole, MA 02543", "isReferencedByCount": 150, "referenceCount": 69, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.1201884109", "pdfUrl": null, "abstract": "Voltage-gated Na + -permeable (Nav) channels form the basis for electrical excitability in animals. Nav channels evolved from Ca 2+ channels and were present in the common ancestor of choanoflagellates and animals, although this channel was likely permeable to both Na + and Ca 2+ . Thus, like many other neuronal channels and receptors, Nav channels predated neurons. Invertebrates possess two Nav channels (Nav1 and Nav2), whereas vertebrate Nav channels are of the Nav1 family. Approximately 500 Mya in early chordates Nav channels evolved a motif that allowed them to cluster at axon initial segments, 50 million years later with the evolution of myelin, Nav channels “capitalized” on this property and clustered at nodes of Ranvier. The enhancement of conduction velocity along with the evolution of jaws likely made early gnathostomes fierce predators and the dominant vertebrates in the ocean. Later in vertebrate evolution, the Nav channel gene family expanded in parallel in tetrapods and teleosts (∼9 to 10 genes in amniotes, 8 in teleosts). This expansion occurred during or after the late Devonian extinction, when teleosts and tetrapods each diversified in their respective habitats, and coincided with an increase in the number of telencephalic nuclei in both groups. The expansion of Nav channels may have allowed for more sophisticated neural computation and tailoring of Nav channel kinetics with potassium channel kinetics to enhance energy savings. Nav channels show adaptive sequence evolution for increasing diversity in communication signals (electric fish), in protection against lethal Nav channel toxins (snakes, newts, pufferfish, insects), and in specialized habitats (naked mole rats).", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1073/pnas.0910723107", "doi": "10.1073/pnas.0910723107", "title": "EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity", "publicationYear": 2010, "publicationDate": "2010-04-27", "type": "journal-article", "publisher": "National Academy of Sciences", "containerTitle": "Proceedings of the National Academy of Sciences", "volume": "107", "issue": "17", "page": "7710-7715", "issn": "0027-8424, 1091-6490", "isbn": null, "authors": "Jan Bieschke, Jenny Russ, Ralf P. Friedrich, Dagmar E. Ehrnhoefer, Heike Wobst, Katja Neugebauer, Erich E. Wanker", "authorCount": 7, "firstAuthorAffiliation": "Max Delbrueck Center for Molecular Medicine, Robert-Roessle-Strasse 10, 13125 Berlin-Buch, Germany", "isReferencedByCount": 960, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1073/pnas.0910723107", "pdfUrl": null, "abstract": "Protein misfolding and formation of β-sheet-rich amyloid fibrils or aggregates is related to cellular toxicity and decay in various human disorders including Alzheimer’s and Parkinson’s disease. Recently, we demonstrated that the polyphenol (-)-epi-gallocatechine gallate (EGCG) inhibits α-synuclein and amyloid-β fibrillogenesis. It associates with natively unfolded polypeptides and promotes the self-assembly of unstructured oligomers of a new type. Whether EGCG disassembles preformed amyloid fibrils, however, remained unclear. Here, we show that EGCG has the ability to convert large, mature α-synuclein and amyloid-β fibrils into smaller, amorphous protein aggregates that are nontoxic to mammalian cells. Mechanistic studies revealed that the compound directly binds to β-sheet-rich aggregates and mediates the conformational change without their disassembly into monomers or small diffusible oligomers. These findings suggest that EGCG is a potent remodeling agent of mature amyloid fibrils.", "subject": null, "language": "en", "_run_id": "vFRQTig20ipQvrnx6", "_dataset_id": "uifn0WjQHe13ejlOC"}
{"paperId": "10.1016/j.stem.2017.05.016", "doi": "10.1016/j.stem.2017.05.016", "title": "Opportunities in Reprogramming: Fred Gage, Kristin Baldwin, and Hongkui Deng", "publicationYear": 2017, "publicationDate": "2017-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "20", "issue": "6", "page": "767-770", "issn": "1934-5909", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2017.05.016", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2016.07.008", "doi": "10.1016/j.stem.2016.07.008", "title": "Deteriorating Infrastructure in the Aged Muscle Stem Cell Niche", "publicationYear": 2016, "publicationDate": "2016-08", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "19", "issue": "2", "page": "150-151", "issn": "1934-5909", "isbn": null, "authors": "Joseph T. Rodgers", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 9, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2016.07.008", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2016.11.013", "doi": "10.1016/j.stem.2016.11.013", "title": "Fetal to Adult Hematopoiesis with the “Flk” of a Switch", "publicationYear": 2016, "publicationDate": "2016-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "19", "issue": "6", "page": "673-674", "issn": "1934-5909", "isbn": null, "authors": "Stijn Vanhee, Joan Yuan", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2016.11.013", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2015.04.017", "doi": "10.1016/j.stem.2015.04.017", "title": "In This Issue", "publicationYear": 2015, "publicationDate": "2015-05", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "16", "issue": "5", "page": "xiii", "issn": "1934-5909", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2015.04.017", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2015.10.011", "doi": "10.1016/j.stem.2015.10.011", "title": "In This Issue", "publicationYear": 2015, "publicationDate": "2015-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "17", "issue": "5", "page": "xi", "issn": "1934-5909", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2015.10.011", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2018.09.014", "doi": "10.1016/j.stem.2018.09.014", "title": "Mentoring the Next Generation: John Dick", "publicationYear": 2018, "publicationDate": "2018-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "23", "issue": "4", "page": "468-470", "issn": "1934-5909", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2018.09.014", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2014.12.012", "doi": "10.1016/j.stem.2014.12.012", "title": "In This Issue", "publicationYear": 2015, "publicationDate": "2015-01", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "16", "issue": "1", "page": "ix", "issn": "1934-5909", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2014.12.012", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2024.04.007", "doi": "10.1016/j.stem.2024.04.007", "title": "Connie Eaves (May 22, 1944–March 7, 2024)", "publicationYear": 2024, "publicationDate": "2024-05", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "31", "issue": "5", "page": "593-596", "issn": "1934-5909", "isbn": null, "authors": "Ali Turhan, Franck Nicolini, François Lemoine, Laure Coulombel, Saghi Ghaffari", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2024.04.007", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2010.12.011", "doi": "10.1016/j.stem.2010.12.011", "title": "A Roundabout Way to the Niche", "publicationYear": 2011, "publicationDate": "2011-01", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "8", "issue": "1", "page": "6-7", "issn": "1934-5909", "isbn": null, "authors": "Kateri Moore", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2010.12.011", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2014.09.011", "doi": "10.1016/j.stem.2014.09.011", "title": "In This Issue", "publicationYear": 2014, "publicationDate": "2014-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "15", "issue": "4", "page": "xv", "issn": "1934-5909", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2014.09.011", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2018.10.021", "doi": "10.1016/j.stem.2018.10.021", "title": "Voices: Crossing the Valley of Death", "publicationYear": 2018, "publicationDate": "2018-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "23", "issue": "5", "page": "639-641", "issn": "1934-5909", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2018.10.021", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2013.12.014", "doi": "10.1016/j.stem.2013.12.014", "title": "Differing Standards for the NIH Stem Cell Registry and FDA Approval Render Most Federally Funded hESC Lines Unsuitable for Clinical Use", "publicationYear": 2014, "publicationDate": "2014-02", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "14", "issue": "2", "page": "139-140", "issn": "1934-5909", "isbn": null, "authors": "Erica C. Jonlin", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 12, "referenceCount": 4, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2013.12.014", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2012.05.002", "doi": "10.1016/j.stem.2012.05.002", "title": "A Great Match", "publicationYear": 2012, "publicationDate": "2012-06", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "10", "issue": "6", "page": "638-639", "issn": "1934-5909", "isbn": null, "authors": "Leonard I. Zon", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2012.05.002", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2011.12.014", "doi": "10.1016/j.stem.2011.12.014", "title": "Untapping the Potential of Human Retinal Pigmented Epithelial Cells", "publicationYear": 2012, "publicationDate": "2012-01", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "10", "issue": "1", "page": "1-2", "issn": "1934-5909", "isbn": null, "authors": "Pete Coffey", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 4, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2011.12.014", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
{"paperId": "10.1016/j.stem.2016.11.007", "doi": "10.1016/j.stem.2016.11.007", "title": "A Quiescent Bcl11b High Stem Cell Population Is Required for Maintenance of the Mammary Gland", "publicationYear": 2017, "publicationDate": "2017-02", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "20", "issue": "2", "page": "247-260.e5", "issn": "1934-5909", "isbn": null, "authors": "Shang Cai, Tomer Kalisky, Debashis Sahoo, Piero Dalerba, Weiguo Feng, Yuan Lin, Dalong Qian, Angela Kong, Jeffrey Yu, Flora Wang, Elizabeth Y. Chen, Ferenc A. Scheeren, Angera H. Kuo, Shaheen S. Sikandar, Shigeo Hisamori, Linda J. van Weele, Diane Heiser, Sopheak Sim, Jessica Lam, Stephen Quake, Michael F. Clarke", "authorCount": 21, "firstAuthorAffiliation": null, "isReferencedByCount": 96, "referenceCount": 60, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Cancer Institute, National Cancer Institute, National Cancer Institute, Breast Cancer Research Foundation, California Institute of Regenerative Medicine, U.S. Department of Defense, National Institutes of Health", "funderIds": "10.13039/100000054, 10.13039/100000054, 10.13039/100000054, 10.13039/100001006, 10.13039/100007557, 10.13039/100000005, 10.13039/100000002", "url": "https://doi.org/10.1016/j.stem.2016.11.007", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
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{"paperId": "10.1016/j.stem.2025.03.006", "doi": "10.1016/j.stem.2025.03.006", "title": "EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity", "publicationYear": 2025, "publicationDate": "2025-04", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cell Stem Cell", "volume": "32", "issue": "4", "page": "670", "issn": "1934-5909", "isbn": null, "authors": "Ran Jing, Irene Scarfo, Mohamad Ali Najia, Edroaldo Lummertz da Rocha, Areum Han, Michael Sanborn, Trevor Bingham, Caroline Kubaczka, Deepak K. Jha, Marcelo Falchetti, Thorsten M. Schlaeger, Trista E. North, Marcela V. Maus, George Q. Daley", "authorCount": 14, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.stem.2025.03.006", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "n4EmbxwhoIT6ILoGV", "_dataset_id": "an9HQtyrKzMvEcwRO"}
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{"paperId": "10.1038/d41586-025-00699-8", "doi": "10.1038/d41586-025-00699-8", "title": "Earliest systematically crafted bone tools date back 1.5 million years", "publicationYear": 2025, "publicationDate": "2025-03-05", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": null, "issue": null, "page": null, "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Nick Petrić Howe, Shamini Bundell", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/d41586-025-00699-8", "pdfUrl": "https://www.nature.com/articles/d41586-025-00699-8.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "dqOqFWSEKD4Xc6Tuh", "_dataset_id": "IDDjSnTd0zPxHVKiX"}
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{"paperId": "10.1038/d41586-022-03419-8", "doi": "10.1038/d41586-022-03419-8", "title": "Grad students’ long overtime , and more — this week’s best science graphics", "publicationYear": 2022, "publicationDate": "2022-10-26", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": null, "issue": null, "page": null, "issn": "0028-0836, 1476-4687", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/d41586-022-03419-8", "pdfUrl": "https://www.nature.com/articles/d41586-022-03419-8.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "dqOqFWSEKD4Xc6Tuh", "_dataset_id": "IDDjSnTd0zPxHVKiX"}
{"paperId": "10.1038/021203c0", "doi": "10.1038/021203c0", "title": "A Query", "publicationYear": 1880, "publicationDate": "1880-01", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "21", "issue": "531", "page": "203-203", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "IGNORAMUS", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/021203c0", "pdfUrl": "http://www.nature.com/articles/021203c0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "dqOqFWSEKD4Xc6Tuh", "_dataset_id": "IDDjSnTd0zPxHVKiX"}
{"paperId": "10.1038/d41586-022-00001-0", "doi": "10.1038/d41586-022-00001-0", "title": "A mighty antibody is the bane of multiple coronaviruses", "publicationYear": 2022, "publicationDate": "2022-01-13", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "601", "issue": "7892", "page": "168-168", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 2, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/d41586-022-00001-0", "pdfUrl": "https://www.nature.com/articles/d41586-022-00001-0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "dqOqFWSEKD4Xc6Tuh", "_dataset_id": "IDDjSnTd0zPxHVKiX"}
{"paperId": "10.1038/073001a0", "doi": "10.1038/073001a0", "title": "An Introduction to the Design of Beams, Girders, and Columns in Machines and Structures, with Examples in Graphic Statics Mechanics for Engineers, a Text-book of Intermediate Standard", "publicationYear": 1905, "publicationDate": "1905-11", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "73", "issue": "1879", "page": "1-2", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "M.", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/073001a0", "pdfUrl": "http://www.nature.com/articles/073001a0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "dqOqFWSEKD4Xc6Tuh", "_dataset_id": "IDDjSnTd0zPxHVKiX"}
{"paperId": "10.1038/121891b0", "doi": "10.1038/121891b0", "title": "Diary of Societies", "publicationYear": 1928, "publicationDate": "1928-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "121", "issue": "3057", "page": "891-892", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/121891b0", "pdfUrl": "http://www.nature.com/articles/121891b0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "dqOqFWSEKD4Xc6Tuh", "_dataset_id": "IDDjSnTd0zPxHVKiX"}
{"paperId": "10.1038/d41586-023-01736-0", "doi": "10.1038/d41586-023-01736-0", "title": "Surgical wonders and dodgy medical ethics: the Hunterian Museum reopens", "publicationYear": 2023, "publicationDate": "2023-06-01", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "618", "issue": "7963", "page": "25-26", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Nisha Gaind", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/d41586-023-01736-0", "pdfUrl": "https://www.nature.com/articles/d41586-023-01736-0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "dqOqFWSEKD4Xc6Tuh", "_dataset_id": "IDDjSnTd0zPxHVKiX"}
{"paperId": "10.1038/021008a0", "doi": "10.1038/021008a0", "title": "Mind in the Lower Animals", "publicationYear": 1879, "publicationDate": "1879-11", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "21", "issue": "523", "page": "8-9", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "GEORGE J. ROMANES", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/021008a0", "pdfUrl": "http://www.nature.com/articles/021008a0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "dqOqFWSEKD4Xc6Tuh", "_dataset_id": "IDDjSnTd0zPxHVKiX"}
{"paperId": "10.1038/133379c0", "doi": "10.1038/133379c0", "title": "Side-Chain Reactions of Benzene Derivatives", "publicationYear": 1934, "publicationDate": "1934-03", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "133", "issue": "3358", "page": "379-380", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "W. S. NATHAN, H. B. WATSON", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 7, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/133379c0", "pdfUrl": "http://www.nature.com/articles/133379c0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "dqOqFWSEKD4Xc6Tuh", "_dataset_id": "IDDjSnTd0zPxHVKiX"}
{"paperId": "10.1038/157127a0", "doi": "10.1038/157127a0", "title": "RELATIONAL PLANT MORPHOLOGY", "publicationYear": 1946, "publicationDate": "1946-02", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "157", "issue": "3979", "page": "127-128", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "R. H. RICHENS", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 18, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/157127a0", "pdfUrl": "http://www.nature.com/articles/157127a0.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "dqOqFWSEKD4Xc6Tuh", "_dataset_id": "IDDjSnTd0zPxHVKiX"}
{"paperId": "10.1055/a-1229-5048", "doi": "10.1055/a-1229-5048", "title": "COVID-19 COVID-19 COVID-19 COVID-19 COVID-19 COVID-19", "publicationYear": 2020, "publicationDate": "2020-11", "type": "journal-article", "publisher": "Georg Thieme Verlag KG", "containerTitle": "Endo-Praxis", "volume": "36", "issue": "04", "page": "173-173", "issn": "0177-4077, 1611-6429", "isbn": null, "authors": "Rainer Duchmann", "authorCount": 1, "firstAuthorAffiliation": "Medizinischen Klinik, Hospital zum heiligen Geist GmbH, Frankfurt/Main", "isReferencedByCount": 5, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1055/a-1229-5048", "pdfUrl": "http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1229-5048.pdf", "abstract": null, "subject": null, "language": "de", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.31038/jipc.2022213", "doi": "10.31038/jipc.2022213", "title": "Anergy in COVID-19 Infected and COVID-19 vaccinee", "publicationYear": 2022, "publicationDate": "2022-06-09", "type": "journal-article", "publisher": "Research Desk Inc", "containerTitle": "Journal of International Perspectives on COVID-19", "volume": "2", "issue": "1", "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.31038/jipc.2022213", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.15", "doi": "10.26524/royal.37.15", "title": "PSYCHOLOGICAL IMPACT OF COVID-19", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "165-175", "issn": null, "isbn": null, "authors": "Divya Dubey", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 11, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.15", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.21", "doi": "10.26524/royal.37.21", "title": "MANAGEMENT STRATEGIES OF COVID - 19", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "214-221", "issn": null, "isbn": null, "authors": "Nissar Reshi", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.21", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.25", "doi": "10.26524/royal.37.25", "title": "THE WORLD AFTER COVID -19", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "248-253", "issn": null, "isbn": null, "authors": "Najeeb Ullah", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.25", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.30554/archmed.21.1.4000.2021", "doi": "10.30554/archmed.21.1.4000.2021", "title": "ENFRENTAR COM SOLIDARIEDADE À COVID-19", "publicationYear": 2021, "publicationDate": "2021-01-25", "type": "journal-article", "publisher": "Universidad de Manizales", "containerTitle": "Archivos de Medicina (Manizales)", "volume": "21", "issue": "1", "page": "285-299", "issn": "2339-3874, 1657-320X", "isbn": null, "authors": "Wladimir Porreca", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.30554/archmed.21.1.4000.2021", "pdfUrl": "https://revistasum.umanizales.edu.co/index.php/archivosmedicina/article/download/4000/6643", "abstract": "The COVID-19 pandemic imposed on humanity rapid and profound changes in the way it lived and related. In this unstable and complex scenario, in which public health and ethical issues were revisited, this essay sought to visualize some solidarity actions to offer elements of reflection in an attempt to deepen the theme on solidarity as a gift of care and responsibility, a human resource effective to face the pandemic reality. In the health crisis with SARS-CoV-2, solidarity rekindled, in people and societies, ethical humanitarian and community attributes, of care and responsibility, which generated solidarity actions in the confrontation and overcoming of COVID-19, Solidarity can be a possible promising and safe path for the development of human and social potential, an ethical paradigm that redirects individual rights towards collective rights and the common good. An ethical duty of care and responsibility for the good of people.", "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1332/policypress/9781529218961.003.0002", "doi": "10.1332/policypress/9781529218961.003.0002", "title": "Is COVID-19 a Housing Disease? Housing, COVID-19 Risk, and COVID-19 Harms in the UK", "publicationYear": 2021, "publicationDate": "2021-07-22", "type": "book-chapter", "publisher": "Policy Press", "containerTitle": "Volume 2: Housing and Home", "volume": null, "issue": null, "page": "19-30", "issn": null, "isbn": "9781529218961, 9781529218992", "authors": "Rebecca Tunstall", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1332/policypress/9781529218961.003.0002", "pdfUrl": null, "abstract": "This chapter examines evidence from the UK to assess whether COVID-19 and lockdown harms are housing diseases. It focuses on poor housing conditions, such as overcrowding and its relationship with poor health, in order to analyze the ongoing harms caused by the pandemic and factors that inhibit abilities to contain it. It also looks at issues concerning the shortage of space, lack of bedrooms, and poor-quality housing to mental health, noting that much of the population are staying at home during lockdowns. The chapter explains that COVID-19 is a disease that exposes vulnerabilities in the UK housing system, in both the public sector and the private market. It points out that the UK has had among the highest COVID-19 death rates in the world.", "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.9", "doi": "10.26524/royal.37.9", "title": "IMMUNE RESPONSE TO COVID-19 INFECTION", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "108-127", "issn": null, "isbn": null, "authors": "Sunusi Dalha, Ibrahim Babangida", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.9", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.28", "doi": "10.26524/royal.37.28", "title": "ADMINISTRATION OF CURRENT MEDICINE AGAINST COVID-19", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "270-277", "issn": null, "isbn": null, "authors": "Harinath P", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.28", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.13", "doi": "10.26524/royal.37.13", "title": "ROLE OF INFORMATION SCIENCE DURING COVID -19", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "148-156", "issn": null, "isbn": null, "authors": "Rahul Reddy Nadikattu", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.13", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.22", "doi": "10.26524/royal.37.22", "title": "EMERGENCE OF ONLINE LEARNING ON COVID 19", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "222-229", "issn": null, "isbn": null, "authors": "Sikender Mohsienuddin Mohammad", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.22", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.29", "doi": "10.26524/royal.37.29", "title": "DEVELOPMENT OF VACCINATION DURING COVID 19", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "278-284", "issn": null, "isbn": null, "authors": "Syed Baker, Komal Kumar J", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.29", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1332/policypress/9781529223125.003.0005", "doi": "10.1332/policypress/9781529223125.003.0005", "title": "Humans, COVID-19 and Platform Societies", "publicationYear": 2022, "publicationDate": "2022-04-26", "type": "book-chapter", "publisher": "Policy Press", "containerTitle": "Being Human During COVID-19", "volume": null, "issue": null, "page": "36-43", "issn": null, "isbn": "9781529223125, 9781529223156", "authors": "Stefania Vicari, Zheng Yang", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1332/policypress/9781529223125.003.0005", "pdfUrl": null, "abstract": "Abstract and Keywords to be supplied.", "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.23", "doi": "10.26524/royal.37.23", "title": "ROLE OF HEALTHCARE PROFESSIONALS IN COVID-19 SITUATION", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "230-238", "issn": null, "isbn": null, "authors": "Priyanka Bhowmik", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.23", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.3718", "doi": "10.26524/royal.3718", "title": "INFLUENCE OF COVID-19 AT GLOBAL LEVEL", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "192-198", "issn": null, "isbn": "9789388413879", "authors": "Mohammed Kamran Aslam", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.3718", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.18", "doi": "10.26524/royal.37.18", "title": "INFLUENCE OF COVID-19 AT GLOBAL LEVEL", "publicationYear": 2020, "publicationDate": "2020-09-30", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "192-198", "issn": null, "isbn": "9789388413879", "authors": "Mohammed Kamran Aslam", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.18", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.27", "doi": "10.26524/royal.37.27", "title": "THE GLOBAL COUNTRY WISE STATISTICS ON COVID-19", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "262-269", "issn": null, "isbn": null, "authors": "Manit Malhotra", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.27", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.11621/rpo.2021.02", "doi": "10.11621/rpo.2021.02", "title": "Psychological risks during the COVID-19 pandemic", "publicationYear": 2021, "publicationDate": "2021", "type": "book-chapter", "publisher": "издательство Московского Университета", "containerTitle": "PSYCHOLOGICAL GUIDANCE DURING THE COVID-19 PANDEMIC", "volume": null, "issue": null, "page": "31-61", "issn": null, "isbn": null, "authors": "S.B. Malykh, M.A. Sitnikova", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.11621/rpo.2021.02", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.31752/idea.2020.13", "doi": "10.31752/idea.2020.13", "title": "ရွေးကောက်ပွဲများနှင့် COVID-19", "publicationYear": 2020, "publicationDate": "2020-04-03", "type": "book", "publisher": "International Institute for Democracy and Electoral Assistance", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "International IDEA", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.31752/idea.2020.13", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.17343/sdutfd.905059", "doi": "10.17343/sdutfd.905059", "title": "Covid-19 Aşıları", "publicationYear": 2021, "publicationDate": "2021-05-01", "type": "journal-article", "publisher": "Medical Journal of Suleyman Demirel University", "containerTitle": "SDÜ Tıp Fakültesi Dergisi", "volume": "28", "issue": "COVİD-19 ÖZEL SAYI", "page": "31-35", "issn": "1300-7416", "isbn": null, "authors": "Onur KAYA", "authorCount": 1, "firstAuthorAffiliation": "SÜLEYMAN DEMİREL ÜNİVERSİTESİ", "isReferencedByCount": 8, "referenceCount": 21, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.17343/sdutfd.905059", "pdfUrl": null, "abstract": "Covid-19 pandemisi 1 yılı aşkın bir süredir devam etmektedir. Alınan çeşitli önlemlere karşın pandemi sonlandırılamamıştır. Bu nedenle aşı çalışmaları önem kazanmıştır. Bazı aşıların etkinliklerinin yüksek olmasına rağmen çalışmalar hala devam etmektedir.", "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.5", "doi": "10.26524/royal.37.5", "title": "NEUROLOGICAL IMPACT OF COVID-19 PANDEMIC: LESSONS &amp; CAUTIONS", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "73-83", "issn": null, "isbn": null, "authors": "Debprasad Dutta", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.5", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.23880/vvoa-16000144", "doi": "10.23880/vvoa-16000144", "title": "Covid-19: Reflections on the Pathology Caused by Coronavirus COVID-19", "publicationYear": 2020, "publicationDate": "2020", "type": "journal-article", "publisher": "Medwin Publishers", "containerTitle": "Vaccines &amp; Vaccination Open Access", "volume": "5", "issue": "3", "page": null, "issn": "2578-5044", "isbn": null, "authors": "Divocha VA", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.23880/vvoa-16000144", "pdfUrl": "https://medwinpublishers.com/VVOA/covid-19-reflections-on-the-pathology-caused-by-coronavirus-covid-19.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.20", "doi": "10.26524/royal.37.20", "title": "IMPACT OF COVID 19 ON THE GLOBAL ECONOMY", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "208-213", "issn": null, "isbn": null, "authors": "Mohammed Naveed ul haq", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.20", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.6", "doi": "10.26524/royal.37.6", "title": "IMPACTS OF THE COVID-19 PANDEMIC ON GLOBAL EDUCATION", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "84-94", "issn": null, "isbn": "9789388413879", "authors": "Santanu De", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 24, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.6", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.17", "doi": "10.26524/royal.37.17", "title": "IMPACT OF COVID-19 ON ACADEMICS AND RESEARCH", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "184-191", "issn": null, "isbn": null, "authors": "Evgeny Soloviov, Alexander Danilov", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.17", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1332/policypress/9781529223125.003.0017", "doi": "10.1332/policypress/9781529223125.003.0017", "title": "Inclusive Education in the Post-COVID-19 World", "publicationYear": 2022, "publicationDate": "2022-04-26", "type": "book-chapter", "publisher": "Policy Press", "containerTitle": "Being Human During COVID-19", "volume": null, "issue": null, "page": "132-139", "issn": null, "isbn": "9781529223125, 9781529223156", "authors": "Anna Pilson", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1332/policypress/9781529223125.003.0017", "pdfUrl": null, "abstract": "Abstract and Keywords to be supplied.", "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.19", "doi": "10.26524/royal.37.19", "title": "INFLUENCE OF COVID-19 ON BUSINESS, MARKETING AND SUPPLY", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "199-207", "issn": null, "isbn": null, "authors": "Hessa Al Kaabi", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.19", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1332/policypress/9781447361190.003.0006", "doi": "10.1332/policypress/9781447361190.003.0006", "title": "COVID-19 and after", "publicationYear": 2021, "publicationDate": "2021-09-30", "type": "book-chapter", "publisher": "Policy Press", "containerTitle": "The Next Welfare State?", "volume": null, "issue": null, "page": "112-125", "issn": null, "isbn": "9781447361190, 9781447361220", "authors": "Christopher Pierson", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1332/policypress/9781447361190.003.0006", "pdfUrl": null, "abstract": "This chapter assesses the impact of COVID-19, and policy responses to it, after a year of special measures. The challenges to health and well-being, mortality, work, welfare, the public finances, and civil liberties have all been severe. This chapter uses a range of data sources to make an assessment of the damage after a year of pandemic. It discusses dynamics of deficit, debt, unemployment, future growth and taxation. Finally, it considers the prospects, in both the short- and medium-term, for welfare after COVID-19.", "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.22541/au.162172392.28881736/v1", "doi": "10.22541/au.162172392.28881736/v1", "title": "From COVID-19 or because COVID-19?", "publicationYear": 2021, "publicationDate": "2021-05-22", "type": "posted-content", "publisher": "Wiley", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Guglielmo Actis Dato", "authorCount": 1, "firstAuthorAffiliation": "Azienda Ospedaliera Ordine Mauriziano di Torino", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22541/au.162172392.28881736/v1", "pdfUrl": null, "abstract": "Infections and pandemics will condition us in an increasingly predominant way regarding diagnostic, medical and surgical activities in all specialist areas; and this particularly in cardiovascular one. Nevertheless in the future the need to cohabit with pandemic events and to be able to continue an elective and not only emergency cardiac surgery program represents an imperative.", "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1016/bs.irn.2022.04.004", "doi": "10.1016/bs.irn.2022.04.004", "title": "Covid-19 and Parkinson's disease: Acute clinical implications, long-COVID and post-COVID-19 parkinsonism", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "International Review of Neurobiology", "volume": null, "issue": null, "page": "63-89", "issn": "0074-7742", "isbn": "9780323991735", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 25, "referenceCount": 77, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/bs.irn.2022.04.004", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.18094/josc.699040", "doi": "10.18094/josc.699040", "title": "Sağlık İletişimi Perspektifinden Instagramda COVID-19 Paylaşımlarının Analizi: #COVID-19", "publicationYear": 2021, "publicationDate": "2021-01-15", "type": "journal-article", "publisher": "Selcuk Iletisim", "containerTitle": "Selçuk İletişim", "volume": "14", "issue": "1", "page": "113-136", "issn": "2148-2942", "isbn": null, "authors": "Banu KUMBASAR", "authorCount": 1, "firstAuthorAffiliation": "İSTANBUL ÜNİVERSİTESİ - CERRAHPAŞA", "isReferencedByCount": 3, "referenceCount": 23, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.18094/josc.699040", "pdfUrl": null, "abstract": "Sosyal medya, COVID-19 gibi salgınlar hakkındaki bilgilerin değerlendirilmesi için önemli bir dijital alanı temsil etmektedir. Ayrıca gerekli sosyal yardım ve müdahalelerin planlanmasında önemli bir araç olarak hizmet edebilmektedir. Pandemi süreçlerinde acil kriz yönetiminde, Twitter, İnstagram, Facebook üzerinden yapılan sosyal medya analizleri durumsal farkındalığı desteklemek için kullanılmaktadır ve bulaşıcı hastalıkların izlenmesinden bölgesel planlama ve çok amaçlı kampanyalara kadar birçok farklı durum için gerekli görülmektedir. Bu çalışmada COVID-19 pandemisinde İnstagram’ın nasıl kullanıldığını belirlemek amaçlanmıştır. İnstagram’da “coronavirus” ve “COVID-19” anahtar kelimesi kullanılarak döküman analizi ile 10 Ocak – 20 Şubat 2020 tarihleri arasında görsel taraması yapılmıştır. Nitel türdeki bu araştırmada verilerin analizinde içerik analizi kullanılmıştır. 334 görselin çoğunda (%35.0) İngilizce altyazı olduğu belirlenmiştir. Görsellerde kullanılan mesaj yaklaşımının çoğunlukla korkutma (%38.9) olduğu saptanmıştır. Görsellerin çoğunluğunun (%71.0) fotoğraf olduğu belirlenmiştir. Fotoğrafları sırasıyla infografik (%17.7) ve karikatür (%11.4) izlemektedir. Paylaşılan görsellerin bilgi vermeye odaklı olduğu görülmüştür. Organizasyonlara ait resmi İnstagram hesapları tarafından paylaşılan kamu yararı taşıyan görsellerin çoğunluğunun (%53.1) haber niteliğinde olduğu saptanmıştır. Haberleri sağlık politikaları (%24.7) ve sosyal pazarlama (%22.2) içerikli görsellerin takip ettiği görülmüştür. Sonuç olarak, pandemi sürecinde İnstagram’ın, gözetim, bilgilendirme ve müdahaleye yardımcı olabilecek, kamuoyunu değerlendirmede katkı sunabilecek bir sosyal medya aracı olabileceği düşünülmektedir.", "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.34921/amj.2020.2.018", "doi": "10.34921/amj.2020.2.018", "title": "COVİD-19: РАДИОДИАГНОСТИЧЕСКИЕ МОМЕНТЫ", "publicationYear": 2020, "publicationDate": "2020-06-30", "type": "journal-article", "publisher": "Azerbaijan Medical Journal", "containerTitle": "Azerbaijan Medical Journal", "volume": null, "issue": "2", "page": "124-129", "issn": "0005-2523", "isbn": null, "authors": "M.C. Sultanova", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 34, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.34921/amj.2020.2.018", "pdfUrl": null, "abstract": "Yeni tip koronavirusla assosiasiya olunan və bu gün bütün dünyanı sarsıdan kəskin respirator xəstəlik bəşəri problemə çevrilmişdir. Bu xəstəlik 2019-cu ilin dekabr ayında Çinin Uhan şəhərində qeydə alınıb və xəstəlik əksər hallarda ikitərəfli pnevmoniya ilə ağırlaşması ilə səciyyələnir. Bu səbəbdən COVİD-19 pnevmoniyasının diaqnostikasında RQ və KT müayinələrinin nəticələrini göstərən və diaqnostikada rəhbər rolu oynayan elmi araşdırmaların praktik nəticələrinin icmalı həm radioloqlar, həm də klinisitlər üçün böyük əhəmiyyətə malikdir. İcmalı tərtib etməkdə əsas məqsədimiz COVİD-19 pnevmoniyası olan xəstələrin şüa-diaqnostik əlamətləri haqqında məlumat vermək və xəstəliyin radioloji portretini yaratmaqdır. Вспышка коронавирусной болезни 2019 года (COVID-19), впервые обнаруженная в Ухане (Китай), быстро охватила весь мир всего за месяц, вызвав глобальную чрезвычайную ситуацию в области общественного здравоохранения. В представленной статье изложен обзор научных исследований, которые демонстрируют результаты рентгенографии и КТ в диагностике пневмонии COVID-19, необходим как для радиологов, так и для клиницистов. Основная цель – анализ радиологических признаков у пациентов с COVID-19 пневмонией. Coronavirus disease 2019 (COVID-19) outbreak, first found in Wuhan, China, has quickly swept around the world just within a month, causing global public health emergency. The article presents the review of scientific researches, which demonstrate the results of Radiography and CT in the diagnosis of COVID-19 pneumonia, is necessary for both radiologists and clinicians. The main aim is analyzing the radiographic signs in patients with COVID-19 pneumonia and creating the radiologic features of the disease.", "subject": null, "language": "az", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.4324/9781003257318-1", "doi": "10.4324/9781003257318-1", "title": "COVID-19", "publicationYear": 2022, "publicationDate": "2022-08-23", "type": "book-chapter", "publisher": "Routledge", "containerTitle": "Covid-19 and Speech-Language Pathology", "volume": null, "issue": null, "page": "1-19", "issn": null, "isbn": "9781003257318", "authors": "Bijoyaa Mohapatra, Ranjini Mohan", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4324/9781003257318-1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1093/law-occ19/e27.013.27", "doi": "10.1093/law-occ19/e27.013.27", "title": "Russia: Legal Response to Covid-19", "publicationYear": 2021, "publicationDate": "2021-09", "type": "reference-entry", "publisher": "Oxford University Press", "containerTitle": "The Oxford Compendium of National Legal Responses to Covid-19", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Khramova Tatiana", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/law-occ19/e27.013.27", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.54617/adoklinikbilimler.1100280", "doi": "10.54617/adoklinikbilimler.1100280", "title": "Perspective of COVID-19 Patients on The Relationship Between Oral Health and COVID-19: Responses During COVID-19 Home-Quarantine", "publicationYear": 2022, "publicationDate": "2022-09-19", "type": "journal-article", "publisher": "Ankara Dis Hekimleri Odasi", "containerTitle": "ADO Klinik Bilimler Dergisi", "volume": "11", "issue": "3", "page": "232-237", "issn": "1307-3540", "isbn": null, "authors": "Sühan GÜRBÜZ, Beste İLASLAN HALLAÇ, Zeki Levent HALLAÇ, Ayşen BODUR", "authorCount": 4, "firstAuthorAffiliation": "GAZİ ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ, DİŞ HEKİMLİĞİ PR.", "isReferencedByCount": 1, "referenceCount": 25, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.54617/adoklinikbilimler.1100280", "pdfUrl": null, "abstract": "Objective: Patients with coronavirus disease-2019 (COVID-19) have been reported to have a variety of oral symptoms, including acute periodontal lesions. However, there are a limited number of studies in the literature reporting the views of COVID-19 patients on oral health. The present study aims to examine the views of COVID-19 patients in-home quarantine regarding the possible relationship between oral health and COVID-19. Material and Methods: A face-to-face interview was conducted by the filiation team with 500 patients with a diagnosis of COVID-19 in-home quarantine, visited between January and April 2021. The patients were asked the question, “Do you think there is a relationship between COVID-19 and oral health?” The answers were analyzed by age, gender, and education level. Results: Of the 500 patients (290 female, age±SD, 38.2±12.7), 216 (43.2%) replied \"yes\". 50.7% of the females and 32.9% of the males responded stating that there is a relationship (p&amp;lt;0.05). Among the patients, 54.9% of those responded as \"there is a relationship\" were Bachelor’s/Master's graduates, while 66% of the patients who said, \"there is no relationship\" were primary school graduates (p&amp;lt;0.05). Conclusions: Among COVID-19 patients in-home quarantine, especially women and patients with higher education levels reported that there may be a relationship between oral health and COVID-19. It is crucial to inform all segments of society about the necessity of improving and maintaining oral hygiene during COVID-19 to reduce both the oral bacterial load and the risk of potential bacterial super-infections.", "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.46692/9781529218985.003", "doi": "10.46692/9781529218985.003", "title": "Is COVID-19 a Housing Disease? Housing, COVID-19 Risk, and COVID-19 Harms in the UK", "publicationYear": 2021, "publicationDate": "2021-07-22", "type": "other", "publisher": "Bristol University Press", "containerTitle": "Volume 2: Housing and Home", "volume": null, "issue": null, "page": "19-30", "issn": null, "isbn": "9781529218985", "authors": "Rebecca Tunstall", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.cambridge.org/core/terms", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.46692/9781529218985.003", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1332/policypress/9781447365884.003.0008", "doi": "10.1332/policypress/9781447365884.003.0008", "title": "The impact of COVID-19 and COVID-19 policy on the housing market", "publicationYear": 2022, "publicationDate": "2022-11-22", "type": "book-chapter", "publisher": "Policy Press", "containerTitle": "Stay Home", "volume": null, "issue": null, "page": "168-176", "issn": null, "isbn": "9781447365884, 9781447365921", "authors": "Becky Tunstall", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1332/policypress/9781447365884.003.0008", "pdfUrl": null, "abstract": "UK policy sought to minimise the impact of the pandemic on the housing market, which was viewed as essential to sustaining economic growth. Home construction and marketing paused only for seven weeks, construction workers received £15.9 billion of pandemic support and at least £4.7 billion was spent on a cut in stamp duty (transactions tax). While completions, transactions and lending reduced in 2020, they soon recovered. In contrast to expectations, house price growth continued at 11% a year throughout 2020 and 2021. This contributed to inequalities in access to home ownership and to wealth.", "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1093/law-occ19/e5.013.5", "doi": "10.1093/law-occ19/e5.013.5", "title": "Chile: Legal Response to Covid-19", "publicationYear": 2021, "publicationDate": "2021-04", "type": "reference-entry", "publisher": "Oxford University Press", "containerTitle": "The Oxford Compendium of National Legal Responses to Covid-19", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Jiménez Guillermo", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/law-occ19/e5.013.5", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1097/01.eem.0000662544.84688.ec", "doi": "10.1097/01.eem.0000662544.84688.ec", "title": "Special Coverage on COVID-19", "publicationYear": 2020, "publicationDate": "2020-04-28", "type": "journal-article", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "containerTitle": "Emergency Medicine News", "volume": "42", "issue": "4C", "page": null, "issn": "1054-0725", "isbn": null, "authors": "Mark Mosley", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1097/01.eem.0000662544.84688.ec", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1093/law-occ19/e14.013.14", "doi": "10.1093/law-occ19/e14.013.14", "title": "Mexico: Legal Response to Covid-19", "publicationYear": 2021, "publicationDate": "2021-04", "type": "reference-entry", "publisher": "Oxford University Press", "containerTitle": "The Oxford Compendium of National Legal Responses to Covid-19", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Villarreal Pedro A", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/law-occ19/e14.013.14", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.16", "doi": "10.26524/royal.37.16", "title": "IMPACT OF COVID-19 ON AERONAUTICAL ENGINEERING", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "176-183", "issn": null, "isbn": null, "authors": "Nishchha a, Margarita N Favorskaya, Angelina N. Zhukovskaya", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.16", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1183/2312508x.10024520", "doi": "10.1183/2312508x.10024520", "title": "Post-COVID-19 rehabilitation", "publicationYear": 2021, "publicationDate": "2021-12", "type": "book-chapter", "publisher": "European Respiratory Society", "containerTitle": "COVID-19", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9781849841481, 9781849841504, 9781849841498", "authors": "Sally Singh", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 80, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1183/2312508x.10024520", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1093/law-occ19/e18.013.18", "doi": "10.1093/law-occ19/e18.013.18", "title": "Taiwan: Legal Response to Covid-19", "publicationYear": 2021, "publicationDate": "2021-07", "type": "reference-entry", "publisher": "Oxford University Press", "containerTitle": "The Oxford Compendium of National Legal Responses to Covid-19", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Lin C-F", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/law-occ19/e18.013.18", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.26524/royal.37.26", "doi": "10.26524/royal.37.26", "title": "THE GLOBAL RACE FOR MOST AWAITED VACCINE AGAINST COVID-19", "publicationYear": 2020, "publicationDate": "2020-09-04", "type": "book-chapter", "publisher": "Royal Book Publishing", "containerTitle": "COVID-19 Pandemic update 2020", "volume": null, "issue": null, "page": "254-261", "issn": null, "isbn": null, "authors": "Neha Keral, Manmohan M.S", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26524/royal.37.26", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.2307/j.ctv1rnpj94.8", "doi": "10.2307/j.ctv1rnpj94.8", "title": "Is COVID-19 a Housing Disease?", "publicationYear": 2021, "publicationDate": "2021-07-22", "type": "book-chapter", "publisher": "Bristol University Press", "containerTitle": "Volume 2: Housing and Home", "volume": null, "issue": null, "page": "19-30", "issn": null, "isbn": "9781529218985, 1529218985, 9781529218961", "authors": "Rebecca Tunstall", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/j.ctv1rnpj94.8", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1093/law-occ19/e7.013.7", "doi": "10.1093/law-occ19/e7.013.7", "title": "Serbia: Legal Response to Covid-19", "publicationYear": 2021, "publicationDate": "2021-04", "type": "reference-entry", "publisher": "Oxford University Press", "containerTitle": "The Oxford Compendium of National Legal Responses to Covid-19", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Krstic Ivana, Davinic Marko", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/law-occ19/e7.013.7", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1093/law-occ19/e30.013.30", "doi": "10.1093/law-occ19/e30.013.30", "title": "Singapore: Legal Response to Covid-19", "publicationYear": 2022, "publicationDate": "2022-05", "type": "reference-entry", "publisher": "Oxford University Press", "containerTitle": "The Oxford Compendium of National Legal Responses to Covid-19", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Neo Jaclyn, Chua Shirin", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/law-occ19/e30.013.30", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
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{"paperId": "10.30875/f27bc8f8-en", "doi": "10.30875/f27bc8f8-en", "title": "The TRIPS Agreement and COVID-19", "publicationYear": 2020, "publicationDate": "2020-10-15", "type": "report-series", "publisher": "World Trade Organization", "containerTitle": "Covid-19 Reports", "volume": null, "issue": null, "page": null, "issn": "2709-5819", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.30875/f27bc8f8-en", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1093/law-occ19/e9.013.9", "doi": "10.1093/law-occ19/e9.013.9", "title": "France: Legal Response to Covid-19", "publicationYear": 2021, "publicationDate": "2021-04", "type": "reference-entry", "publisher": "Oxford University Press", "containerTitle": "The Oxford Compendium of National Legal Responses to Covid-19", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Chambas Estelle, Perroud Thomas", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/law-occ19/e9.013.9", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "FfDA9S5UMZK6Mo4Jo", "_dataset_id": "9Jhv4MiT3gcG3KjeN"}
{"paperId": "10.1007/978-3-319-24574-4_28", "doi": "10.1007/978-3-319-24574-4_28", "title": "U-Net: Convolutional Networks for Biomedical Image Segmentation", "publicationYear": 2015, "publicationDate": "2015", "type": "book-chapter", "publisher": "Springer International Publishing", "containerTitle": "Lecture Notes in Computer Science", "volume": null, "issue": null, "page": "234-241", "issn": "0302-9743, 1611-3349", "isbn": "9783319245737, 9783319245744", "authors": "Olaf Ronneberger, Philipp Fischer, Thomas Brox", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 59676, "referenceCount": 14, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-3-319-24574-4_28", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1038/s41592-019-0686-2", "doi": "10.1038/s41592-019-0686-2", "title": "SciPy 1.0: fundamental algorithms for scientific computing in Python", "publicationYear": 2020, "publicationDate": "2020-03-02", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Methods", "volume": "17", "issue": "3", "page": "261-272", "issn": "1548-7091, 1548-7105", "isbn": null, "authors": "Pauli Virtanen, Ralf Gommers, Travis E. Oliphant, Matt Haberland, Tyler Reddy, David Cournapeau, Evgeni Burovski, Pearu Peterson, Warren Weckesser, Jonathan Bright, Stéfan J. van der Walt, Matthew Brett, Joshua Wilson, K. Jarrod Millman, Nikolay Mayorov, Andrew R. J. Nelson, Eric Jones, Robert Kern, Eric Larson, C J Carey, İlhan Polat, Yu Feng, Eric W. Moore, Jake VanderPlas, Denis Laxalde, Josef Perktold, Robert Cimrman, Ian Henriksen, E. A. Quintero, Charles R. Harris, Anne M. Archibald, Antônio H. Ribeiro, Fabian Pedregosa, Paul van Mulbregt, SciPy 1.0 Contributors, Aditya Vijaykumar, Alessandro Pietro Bardelli, Alex Rothberg, Andreas Hilboll, Andreas Kloeckner, Anthony Scopatz, Antony Lee, Ariel Rokem, C. Nathan Woods, Chad Fulton, Charles Masson, Christian Häggström, Clark Fitzgerald, David A. Nicholson, David R. Hagen, Dmitrii V. Pasechnik, Emanuele Olivetti, Eric Martin, Eric Wieser, Fabrice Silva, Felix Lenders, Florian Wilhelm, G. Young, Gavin A. Price, Gert-Ludwig Ingold, Gregory E. Allen, Gregory R. Lee, Hervé Audren, Irvin Probst, Jörg P. Dietrich, Jacob Silterra, James T Webber, Janko Slavič, Joel Nothman, Johannes Buchner, Johannes Kulick, Johannes L. Schönberger, José Vinícius de Miranda Cardoso, Joscha Reimer, Joseph Harrington, Juan Luis Cano Rodríguez, Juan Nunez-Iglesias, Justin Kuczynski, Kevin Tritz, Martin Thoma, Matthew Newville, Matthias Kümmerer, Maximilian Bolingbroke, Michael Tartre, Mikhail Pak, Nathaniel J. Smith, Nikolai Nowaczyk, Nikolay Shebanov, Oleksandr Pavlyk, Per A. Brodtkorb, Perry Lee, Robert T. McGibbon, Roman Feldbauer, Sam Lewis, Sam Tygier, Scott Sievert, Sebastiano Vigna, Stefan Peterson, Surhud More, Tadeusz Pudlik, Takuya Oshima, Thomas J. Pingel, Thomas P. Robitaille, Thomas Spura, Thouis R. Jones, Tim Cera, Tim Leslie, Tiziano Zito, Tom Krauss, Utkarsh Upadhyay, Yaroslav O. Halchenko, Yoshiki Vázquez-Baeza", "authorCount": 112, "firstAuthorAffiliation": null, "isReferencedByCount": 36397, "referenceCount": 122, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/s41592-019-0686-2", "pdfUrl": "http://www.nature.com/articles/s41592-019-0686-2.pdf", "abstract": "Abstract SciPy is an open-source scientific computing library for the Python programming language. Since its initial release in 2001, SciPy has become a de facto standard for leveraging scientific algorithms in Python, with over 600 unique code contributors, thousands of dependent packages, over 100,000 dependent repositories and millions of downloads per year. In this work, we provide an overview of the capabilities and development practices of SciPy 1.0 and highlight some recent technical developments.", "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1109/mcse.2007.55", "doi": "10.1109/mcse.2007.55", "title": "Matplotlib: A 2D Graphics Environment", "publicationYear": 2007, "publicationDate": "2007", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "Computing in Science &amp; Engineering", "volume": "9", "issue": "3", "page": "90-95", "issn": "1521-9615", "isbn": null, "authors": "John D. Hunter", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 35503, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/mcse.2007.55", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1093/molbev/msy096", "doi": "10.1093/molbev/msy096", "title": "MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms", "publicationYear": 2018, "publicationDate": "2018-06-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Molecular Biology and Evolution", "volume": "35", "issue": "6", "page": "1547-1549", "issn": "0737-4038, 1537-1719", "isbn": null, "authors": "Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura", "authorCount": 5, "firstAuthorAffiliation": "Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA", "isReferencedByCount": 33703, "referenceCount": 5, "isOpenAccess": true, "licenseUrl": "http://academic.oup.com/journals/pages/about_us/legal/notices", "funderNames": "National Institutes of Health, National Science Foundation, Japan Society for the Promotion of Science (JSPS)", "funderIds": "10.13039/100000002, 10.13039/100000001", "url": "https://doi.org/10.1093/molbev/msy096", "pdfUrl": "http://academic.oup.com/mbe/article-pdf/35/6/1547/25091958/msy096.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1063/1.1699114", "doi": "10.1063/1.1699114", "title": "Equation of State Calculations by Fast Computing Machines", "publicationYear": 1953, "publicationDate": "1953-06-01", "type": "journal-article", "publisher": "AIP Publishing", "containerTitle": "The Journal of Chemical Physics", "volume": "21", "issue": "6", "page": "1087-1092", "issn": "0021-9606, 1089-7690", "isbn": null, "authors": "Nicholas Metropolis, Arianna W. Rosenbluth, Marshall N. Rosenbluth, Augusta H. Teller, Edward Teller", "authorCount": 5, "firstAuthorAffiliation": "Los Alamos Scientific Laboratory, Los Alamos, New Mexico", "isReferencedByCount": 29949, "referenceCount": 2, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1063/1.1699114", "pdfUrl": "https://pubs.aip.org/aip/jcp/article-pdf/21/6/1087/18802390/1087_1_online.pdf", "abstract": "A general method, suitable for fast computing machines, for investigating such properties as equations of state for substances consisting of interacting individual molecules is described. The method consists of a modified Monte Carlo integration over configuration space. Results for the two-dimensional rigid-sphere system have been obtained on the Los Alamos MANIAC and are presented here. These results are compared to the free volume equation of state and to a four-term virial coefficient expansion.", "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1088/0953-8984/21/39/395502", "doi": "10.1088/0953-8984/21/39/395502", "title": "QUANTUM ESPRESSO: a modular and open-source software project for quantum simulations of materials", "publicationYear": 2009, "publicationDate": "2009-09-30", "type": "journal-article", "publisher": "IOP Publishing", "containerTitle": "Journal of Physics: Condensed Matter", "volume": "21", "issue": "39", "page": "395502", "issn": "0953-8984, 1361-648X", "isbn": null, "authors": "Paolo Giannozzi, Stefano Baroni, Nicola Bonini, Matteo Calandra, Roberto Car, Carlo Cavazzoni, Davide Ceresoli, Guido L Chiarotti, Matteo Cococcioni, Ismaila Dabo, Andrea Dal Corso, Stefano de Gironcoli, Stefano Fabris, Guido Fratesi, Ralph Gebauer, Uwe Gerstmann, Christos Gougoussis, Anton Kokalj, Michele Lazzeri, Layla Martin-Samos, Nicola Marzari, Francesco Mauri, Riccardo Mazzarello, Stefano Paolini, Alfredo Pasquarello, Lorenzo Paulatto, Carlo Sbraccia, Sandro Scandolo, Gabriele Sclauzero, Ari P Seitsonen, Alexander Smogunov, Paolo Umari, Renata M Wentzcovitch", "authorCount": 33, "firstAuthorAffiliation": null, "isReferencedByCount": 22938, "referenceCount": 193, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1088/0953-8984/21/39/395502", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1007/978-0-387-21706-2", "doi": "10.1007/978-0-387-21706-2", "title": "Modern Applied Statistics with S", "publicationYear": 2002, "publicationDate": "2002", "type": "book", "publisher": "Springer New York", "containerTitle": "Statistics and Computing", "volume": null, "issue": null, "page": null, "issn": "1431-8784", "isbn": "9781441930088, 9780387217062", "authors": "W. N. Venables, B. D. Ripley", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 17377, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-0-387-21706-2", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/978-0-387-21706-2.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1021/cr9904009", "doi": "10.1021/cr9904009", "title": "Quantum Mechanical Continuum Solvation Models", "publicationYear": 2005, "publicationDate": "2005-08-01", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Chemical Reviews", "volume": "105", "issue": "8", "page": "2999-3094", "issn": "0009-2665, 1520-6890", "isbn": null, "authors": "Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi", "authorCount": 3, "firstAuthorAffiliation": "Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Risorgimento 35, 56126 Pisa, Italy, and Dipartimento di Chimica, Università di Parma, Viale delle Scienze 17/A, 43100 Parma, Italy", "isReferencedByCount": 16221, "referenceCount": 920, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/cr9904009", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1038/nmeth.2109", "doi": "10.1038/nmeth.2109", "title": "jModelTest 2: more models, new heuristics and parallel computing", "publicationYear": 2012, "publicationDate": "2012-08", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature Methods", "volume": "9", "issue": "8", "page": "772-772", "issn": "1548-7091, 1548-7105", "isbn": null, "authors": "Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 14776, "referenceCount": 5, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nmeth.2109", "pdfUrl": "https://www.nature.com/articles/nmeth.2109.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1038/nature04235", "doi": "10.1038/nature04235", "title": "Experimental observation of the quantum Hall effect and Berry's phase in graphene", "publicationYear": 2005, "publicationDate": "2005-11", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "438", "issue": "7065", "page": "201-204", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Yuanbo Zhang, Yan-Wen Tan, Horst L. Stormer, Philip Kim", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 12527, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/nature04235", "pdfUrl": "http://www.nature.com/articles/nature04235.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1093/oso/9780198551683.001.0001", "doi": "10.1093/oso/9780198551683.001.0001", "title": "Atoms in Molecules", "publicationYear": 1990, "publicationDate": "1990-12-13", "type": "edited-book", "publisher": "Oxford University PressOxford", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780198551683, 9781383028355", "authors": "Richard F W Bader", "authorCount": 1, "firstAuthorAffiliation": "Department of Chemistry, McMaster University, Ontario, Canada", "isReferencedByCount": 12516, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/oso/9780198551683.001.0001", "pdfUrl": null, "abstract": "Abstract The molecular structure hypothesis - that a molecule is a collection of atoms linked by a network of bonds - was forged in the crucible of nineteenth-century experimental chemistry and has continued to serve as the principal means of ordering and classifying the observations of chemistry. There is a difficulty with the hypothesis, however, in that it is not related directly to the physics which governs the motions of the nuclei and electrons that make up the atoms and the bonds. It is the purpose of this important new book to show that a theory can be developed to underpin the molecular structure hypothesis - that the atoms in a molecule are real, with properties predicted and defined by the laws of quantum mechanics, and that the structure their presence imparts to a molecule is indeed a consequence of the underlying physics. As a result the classification based upon the concept of atoms in molecules is freed from its empirical constraints and the full predictive power of quantum mechanics. As a result the full predictive power of quantum mechanics can be incorporated into the resulting theory - a theory of atoms in molecules. The book is aimed at those scientists responsible for performing the experiments and collecting the observations on the properties of matter at the atomic level, in the belief that the transformation of qualitative concepts into a quantitative theory will serve to deepen our understanding of chemistry.", "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1103/physrev.47.777", "doi": "10.1103/physrev.47.777", "title": "Can Quantum-Mechanical Description of Physical Reality Be Considered Complete?", "publicationYear": 1935, "publicationDate": "1935-05-15", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Physical Review", "volume": "47", "issue": "10", "page": "777-780", "issn": "0031-899X", "isbn": null, "authors": "A. Einstein, B. Podolsky, N. Rosen", "authorCount": 3, "firstAuthorAffiliation": "Institute for Advanced Study, Princeton, New Jersey", "isReferencedByCount": 12330, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://link.aps.org/licenses/aps-default-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1103/physrev.47.777", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1215/9780822388128", "doi": "10.1215/9780822388128", "title": "Meeting the Universe Halfway", "publicationYear": 2006, "publicationDate": "2006", "type": "edited-book", "publisher": "Duke University Press", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780822388128, 9780822339014", "authors": "Karen Barad", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 12089, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1215/9780822388128", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1103/physrevlett.70.1895", "doi": "10.1103/physrevlett.70.1895", "title": "Teleporting an unknown quantum state via dual classical and Einstein-Podolsky-Rosen channels", "publicationYear": 1993, "publicationDate": "1993-03-29", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Physical Review Letters", "volume": "70", "issue": "13", "page": "1895-1899", "issn": "0031-9007", "isbn": null, "authors": "Charles H. Bennett, Gilles Brassard, Claude Crépeau, Richard Jozsa, Asher Peres, William K. Wootters", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 11994, "referenceCount": 19, "isOpenAccess": true, "licenseUrl": "http://link.aps.org/licenses/aps-default-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1103/physrevlett.70.1895", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1021/ja00299a024", "doi": "10.1021/ja00299a024", "title": "Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model", "publicationYear": 1985, "publicationDate": "1985-06", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Journal of the American Chemical Society", "volume": "107", "issue": "13", "page": "3902-3909", "issn": "0002-7863, 1520-5126", "isbn": null, "authors": "Michael J. S. Dewar, Eve G. Zoebisch, Eamonn F. Healy, James J. P. Stewart", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 11838, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/ja00299a024", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1093/jee/18.2.265a", "doi": "10.1093/jee/18.2.265a", "title": "A Method of Computing the Effectiveness of an Insecticide", "publicationYear": 1925, "publicationDate": "1925-04-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Journal of Economic Entomology", "volume": "18", "issue": "2", "page": "265-267", "issn": "1938-291X, 0022-0493", "isbn": null, "authors": "W. S. Abbott", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 11042, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/jee/18.2.265a", "pdfUrl": "http://academic.oup.com/jee/article-pdf/18/2/265/19183043/jee18-0265a.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1126/science.271.5251.933", "doi": "10.1126/science.271.5251.933", "title": "Semiconductor Clusters, Nanocrystals, and Quantum Dots", "publicationYear": 1996, "publicationDate": "1996-02-16", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "271", "issue": "5251", "page": "933-937", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "A. P. Alivisatos", "authorCount": 1, "firstAuthorAffiliation": "The author is in the Department of Chemistry, University of California, and Materials Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA.", "isReferencedByCount": 10582, "referenceCount": 31, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.271.5251.933", "pdfUrl": null, "abstract": "Current research into semiconductor clusters is focused on the properties of quantum dots—fragments of semiconductor consisting of hundreds to many thousands of atoms—with the bulk bonding geometry and with surface states eliminated by enclosure in a material that has a larger band gap. Quantum dots exhibit strongly size-dependent optical and electrical properties. The ability to join the dots into complex assemblies creates many opportunities for scientific discovery.", "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1021/cr030698+", "doi": "10.1021/cr030698+", "title": "Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and Nanotechnology", "publicationYear": 2004, "publicationDate": "2004-01-01", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Chemical Reviews", "volume": "104", "issue": "1", "page": "293-346", "issn": "0009-2665, 1520-6890", "isbn": null, "authors": "Marie-Christine Daniel, Didier Astruc", "authorCount": 2, "firstAuthorAffiliation": "Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No. 5802, Université Bordeaux I, 33405 Talence Cedex, France", "isReferencedByCount": 10370, "referenceCount": 833, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/cr030698+", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1023/b-stco.0000035301.49549.88", "doi": "10.1023/b:stco.0000035301.49549.88", "title": "A tutorial on support vector regression", "publicationYear": 2004, "publicationDate": "2004-08", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Statistics and Computing", "volume": "14", "issue": "3", "page": "199-222", "issn": "0960-3174, 1573-1375", "isbn": null, "authors": "Alex J. Smola, Bernhard Schölkopf", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 10181, "referenceCount": 137, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1023/b:stco.0000035301.49549.88", "pdfUrl": "https://link.springer.com/content/pdf/10.1023/B:STCO.0000035301.49549.88.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1145/331499.331504", "doi": "10.1145/331499.331504", "title": "Data clustering", "publicationYear": 1999, "publicationDate": "1999-09", "type": "journal-article", "publisher": "Association for Computing Machinery (ACM)", "containerTitle": "ACM Computing Surveys", "volume": "31", "issue": "3", "page": "264-323", "issn": "0360-0300, 1557-7341", "isbn": null, "authors": "A. K. Jain, M. N. Murty, P. J. Flynn", "authorCount": 3, "firstAuthorAffiliation": "Michigan State Univ., East Lansing", "isReferencedByCount": 9716, "referenceCount": 205, "isOpenAccess": true, "licenseUrl": "https://www.acm.org/publications/policies/copyright_policy#Background", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1145/331499.331504", "pdfUrl": null, "abstract": "Clustering is the unsupervised classification of patterns (observations, data items, or feature vectors) into groups (clusters). The clustering problem has been addressed in many contexts and by researchers in many disciplines; this reflects its broad appeal and usefulness as one of the steps in exploratory data analysis. However, clustering is a difficult problem combinatorially, and differences in assumptions and contexts in different communities has made the transfer of useful generic concepts and methodologies slow to occur. This paper presents an overview of pattern clustering methods from a statistical pattern recognition perspective, with a goal of providing useful advice and references to fundamental concepts accessible to the broad community of clustering practitioners. We present a taxonomy of clustering techniques, and identify cross-cutting themes and recent advances. We also describe some important applications of clustering algorithms such as image segmentation, object recognition, and information retrieval.", "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1021/jp9716997", "doi": "10.1021/jp9716997", "title": "Quantum Calculation of Molecular Energies and Energy Gradients in Solution by a Conductor Solvent Model", "publicationYear": 1998, "publicationDate": "1998-03-01", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "The Journal of Physical Chemistry A", "volume": "102", "issue": "11", "page": "1995-2001", "issn": "1089-5639, 1520-5215", "isbn": null, "authors": "Vincenzo Barone, Maurizio Cossi", "authorCount": 2, "firstAuthorAffiliation": "Dipartimento di Chimica, Università Federico II, via Mezzocannone 4, I-80134 Napoli, Italy", "isReferencedByCount": 9637, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/jp9716997", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1103/physrevlett.67.661", "doi": "10.1103/physrevlett.67.661", "title": "Quantum cryptography based on Bell’s theorem", "publicationYear": 1991, "publicationDate": "1991-08-05", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Physical Review Letters", "volume": "67", "issue": "6", "page": "661-663", "issn": "0031-9007", "isbn": null, "authors": "Artur K. Ekert", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 9337, "referenceCount": 11, "isOpenAccess": true, "licenseUrl": "http://link.aps.org/licenses/aps-default-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1103/physrevlett.67.661", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1145/1541880.1541882", "doi": "10.1145/1541880.1541882", "title": "Anomaly detection", "publicationYear": 2009, "publicationDate": "2009-07", "type": "journal-article", "publisher": "Association for Computing Machinery (ACM)", "containerTitle": "ACM Computing Surveys", "volume": "41", "issue": "3", "page": "1-58", "issn": "0360-0300, 1557-7341", "isbn": null, "authors": "Varun Chandola, Arindam Banerjee, Vipin Kumar", "authorCount": 3, "firstAuthorAffiliation": "University of Minnesota, Minneapolis, MN", "isReferencedByCount": 9319, "referenceCount": 360, "isOpenAccess": true, "licenseUrl": "https://www.acm.org/publications/policies/copyright_policy#Background", "funderNames": "Advanced Cyberinfrastructure, National Science Foundation, National Aeronautics and Space Administration, Division of Information and Intelligent Systems, Division of Computer and Network Systems", "funderIds": "10.13039/100007523, 10.13039/100000001, 10.13039/100000104, 10.13039/100000145, 10.13039/100000144", "url": "https://doi.org/10.1145/1541880.1541882", "pdfUrl": null, "abstract": "Anomaly detection is an important problem that has been researched within diverse research areas and application domains. Many anomaly detection techniques have been specifically developed for certain application domains, while others are more generic. This survey tries to provide a structured and comprehensive overview of the research on anomaly detection. We have grouped existing techniques into different categories based on the underlying approach adopted by each technique. For each category we have identified key assumptions, which are used by the techniques to differentiate between normal and anomalous behavior. When applying a given technique to a particular domain, these assumptions can be used as guidelines to assess the effectiveness of the technique in that domain. For each category, we provide a basic anomaly detection technique, and then show how the different existing techniques in that category are variants of the basic technique. This template provides an easier and more succinct understanding of the techniques belonging to each category. Further, for each category, we identify the advantages and disadvantages of the techniques in that category. We also provide a discussion on the computational complexity of the techniques since it is an important issue in real application domains. We hope that this survey will provide a better understanding of the different directions in which research has been done on this topic, and how techniques developed in one area can be applied in domains for which they were not intended to begin with.", "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1103/revmodphys.81.865", "doi": "10.1103/revmodphys.81.865", "title": "Quantum entanglement", "publicationYear": 2009, "publicationDate": "2009-06-17", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Reviews of Modern Physics", "volume": "81", "issue": "2", "page": "865-942", "issn": "0034-6861, 1539-0756", "isbn": null, "authors": "Ryszard Horodecki, Paweł Horodecki, Michał Horodecki, Karol Horodecki", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 9114, "referenceCount": 705, "isOpenAccess": true, "licenseUrl": "http://link.aps.org/licenses/aps-default-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1103/revmodphys.81.865", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1109/mcse.2011.37", "doi": "10.1109/mcse.2011.37", "title": "The NumPy Array: A Structure for Efficient Numerical Computation", "publicationYear": 2011, "publicationDate": "2011-03", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "Computing in Science &amp; Engineering", "volume": "13", "issue": "2", "page": "22-30", "issn": "1521-9615, 1558-366X", "isbn": null, "authors": "Stefan van der Walt, S. Chris Colbert, Gael Varoquaux", "authorCount": 3, "firstAuthorAffiliation": "Stellenbosch University", "isReferencedByCount": 9092, "referenceCount": 2, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/mcse.2011.37", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1137/0907058", "doi": "10.1137/0907058", "title": "GMRES: A Generalized Minimal Residual Algorithm for Solving Nonsymmetric Linear Systems", "publicationYear": 1986, "publicationDate": "1986-07", "type": "journal-article", "publisher": "Society for Industrial & Applied Mathematics (SIAM)", "containerTitle": "SIAM Journal on Scientific and Statistical Computing", "volume": "7", "issue": "3", "page": "856-869", "issn": "0196-5204, 2168-3417", "isbn": null, "authors": "Youcef Saad, Martin H. Schultz", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 8732, "referenceCount": 12, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1137/0907058", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1093/mind/lix.236.433", "doi": "10.1093/mind/lix.236.433", "title": "I.—COMPUTING MACHINERY AND INTELLIGENCE", "publicationYear": 1950, "publicationDate": "1950-10-01", "type": "journal-article", "publisher": "Oxford University Press (OUP)", "containerTitle": "Mind", "volume": "LIX", "issue": "236", "page": "433-460", "issn": "1460-2113, 0026-4423", "isbn": null, "authors": "A. M. TURING", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 8669, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/mind/lix.236.433", "pdfUrl": "https://academic.oup.com/mind/article-pdf/LIX/236/433/61209000/mind_lix_236_433.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1103/physrev.40.749", "doi": "10.1103/physrev.40.749", "title": "On the Quantum Correction For Thermodynamic Equilibrium", "publicationYear": 1932, "publicationDate": "1932-06-01", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Physical Review", "volume": "40", "issue": "5", "page": "749-759", "issn": "0031-899X", "isbn": null, "authors": "E. Wigner", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 8338, "referenceCount": 12, "isOpenAccess": true, "licenseUrl": "http://link.aps.org/licenses/aps-default-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1103/physrev.40.749", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1109/3.53394", "doi": "10.1109/3.53394", "title": "Sensitive measurement of optical nonlinearities using a single beam", "publicationYear": 1990, "publicationDate": "1990-04", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Journal of Quantum Electronics", "volume": "26", "issue": "4", "page": "760-769", "issn": "0018-9197", "isbn": null, "authors": "M. Sheik-Bahae, A.A. Said, T.-H. Wei, D.J. Hagan, E.W. Van Stryland", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 8325, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/3.53394", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.25080/majora-92bf1922-00a", "doi": "10.25080/majora-92bf1922-00a", "title": "Data Structures for Statistical Computing in Python", "publicationYear": 2010, "publicationDate": "2010", "type": "proceedings-article", "publisher": "SciPy", "containerTitle": "Proceedings of the Python in Science Conference", "volume": null, "issue": null, "page": "56-61", "issn": "2575-9752", "isbn": null, "authors": "Wes McKinney", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 8309, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.25080/majora-92bf1922-00a", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1016/j.mri.2012.05.001", "doi": "10.1016/j.mri.2012.05.001", "title": "3D Slicer as an image computing platform for the Quantitative Imaging Network", "publicationYear": 2012, "publicationDate": "2012-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Magnetic Resonance Imaging", "volume": "30", "issue": "9", "page": "1323-1341", "issn": "0730-725X", "isbn": null, "authors": "Andriy Fedorov, Reinhard Beichel, Jayashree Kalpathy-Cramer, Julien Finet, Jean-Christophe Fillion-Robin, Sonia Pujol, Christian Bauer, Dominique Jennings, Fiona Fennessy, Milan Sonka, John Buatti, Stephen Aylward, James V. Miller, Steve Pieper, Ron Kikinis", "authorCount": 15, "firstAuthorAffiliation": null, "isReferencedByCount": 8228, "referenceCount": 69, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.mri.2012.05.001", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1007/978-1-4419-0318-1", "doi": "10.1007/978-1-4419-0318-1", "title": "Mixed-Effects Models in Sand S-PLUS", "publicationYear": 2000, "publicationDate": "2000", "type": "book", "publisher": "Springer New York", "containerTitle": "Statistics and Computing", "volume": null, "issue": null, "page": null, "issn": "1431-8784", "isbn": "9781441903174, 9781441903181", "authors": "José C. Pinheiro, Douglas M. Bates", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 8009, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-1-4419-0318-1", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/978-1-4419-0318-1.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1007/s11222-007-9033-z", "doi": "10.1007/s11222-007-9033-z", "title": "A tutorial on spectral clustering", "publicationYear": 2007, "publicationDate": "2007-12", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Statistics and Computing", "volume": "17", "issue": "4", "page": "395-416", "issn": "0960-3174, 1573-1375", "isbn": null, "authors": "Ulrike von Luxburg", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 7985, "referenceCount": 67, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s11222-007-9033-z", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/s11222-007-9033-z.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1109/gce.2010.5676129", "doi": "10.1109/gce.2010.5676129", "title": "Creating the CIPRES Science Gateway for inference of large phylogenetic trees", "publicationYear": 2010, "publicationDate": "2010-11", "type": "proceedings-article", "publisher": "IEEE", "containerTitle": "2010 Gateway Computing Environments Workshop (GCE)", "volume": null, "issue": null, "page": "1-8", "issn": null, "isbn": null, "authors": "Mark A. Miller, Wayne Pfeiffer, Terri Schwartz", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 7917, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/gce.2010.5676129", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.22331/q-2018-08-06-79", "doi": "10.22331/q-2018-08-06-79", "title": "Quantum Computing in the NISQ era and beyond", "publicationYear": 2018, "publicationDate": "2018-08-06", "type": "journal-article", "publisher": "Verein zur Forderung des Open Access Publizierens in den Quantenwissenschaften", "containerTitle": "Quantum", "volume": "2", "issue": null, "page": "79", "issn": "2521-327X", "isbn": null, "authors": "John Preskill", "authorCount": 1, "firstAuthorAffiliation": "Institute for Quantum Information and Matter and Walter Burke Institute for Theoretical Physics, California Institute of Technology, Pasadena CA 91125, USA", "isReferencedByCount": 7586, "referenceCount": 57, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22331/q-2018-08-06-79", "pdfUrl": null, "abstract": "Noisy Intermediate-Scale Quantum (NISQ) technology will be available in the near future. Quantum computers with 50-100 qubits may be able to perform tasks which surpass the capabilities of today's classical digital computers, but noise in quantum gates will limit the size of quantum circuits that can be executed reliably. NISQ devices will be useful tools for exploring many-body quantum physics, and may have other useful applications, but the 100-qubit quantum computer will not change the world right away - we should regard it as a significant step toward the more powerful quantum technologies of the future. Quantum technologists should continue to strive for more accurate quantum gates and, eventually, fully fault-tolerant quantum computing.", "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1088/1361-648x/aa8f79", "doi": "10.1088/1361-648x/aa8f79", "title": "Advanced capabilities for materials modelling with Q <scp>uantum</scp> ESPRESSO", "publicationYear": 2017, "publicationDate": "2017-11-22", "type": "journal-article", "publisher": "IOP Publishing", "containerTitle": "Journal of Physics: Condensed Matter", "volume": "29", "issue": "46", "page": "465901", "issn": "0953-8984, 1361-648X", "isbn": null, "authors": "P Giannozzi, O Andreussi, T Brumme, O Bunau, M Buongiorno Nardelli, M Calandra, R Car, C Cavazzoni, D Ceresoli, M Cococcioni, N Colonna, I Carnimeo, A Dal Corso, S de Gironcoli, P Delugas, R A DiStasio, A Ferretti, A Floris, G Fratesi, G Fugallo, R Gebauer, U Gerstmann, F Giustino, T Gorni, J Jia, M Kawamura, H-Y Ko, A Kokalj, E Küçükbenli, M Lazzeri, M Marsili, N Marzari, F Mauri, N L Nguyen, H-V Nguyen, A Otero-de-la-Roza, L Paulatto, S Poncé, D Rocca, R Sabatini, B Santra, M Schlipf, A P Seitsonen, A Smogunov, I Timrov, T Thonhauser, P Umari, N Vast, X Wu, S Baroni", "authorCount": 50, "firstAuthorAffiliation": "University of Udine", "isReferencedByCount": 7362, "referenceCount": 215, "isOpenAccess": true, "licenseUrl": "https://publishingsupport.iopscience.iop.org/iop-standard/v1", "funderNames": "Leverhulme Trust, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Division of Materials Research, H2020 Research Infrastructures, U.S. Department of Defense, PASC Platform for Advanced Scientific Computing, Office of Science", "funderIds": "10.13039/501100000275, 10.13039/501100001711, 10.13039/100000078, 10.13039/100010666, 10.13039/100006132", "url": "https://doi.org/10.1088/1361-648x/aa8f79", "pdfUrl": "http://iopscience.iop.org/article/10.1088/1361-648X/aa8f79/pdf", "abstract": "Abstract Q uantum ESPRESSO is an integrated suite of open-source computer codes for quantum simulations of materials using state-of-the-art electronic-structure techniques, based on density-functional theory, density-functional perturbation theory, and many-body perturbation theory, within the plane-wave pseudopotential and projector-augmented-wave approaches. Q uantum ESPRESSO owes its popularity to the wide variety of properties and processes it allows to simulate, to its performance on an increasingly broad array of hardware architectures, and to a community of researchers that rely on its capabilities as a core open-source development platform to implement their ideas. In this paper we describe recent extensions and improvements, covering new methodologies and property calculators, improved parallelization, code modularization, and extended interoperability both within the distribution and with external software.", "subject": null, "language": null, "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1109/jiot.2016.2579198", "doi": "10.1109/jiot.2016.2579198", "title": "Edge Computing: Vision and Challenges", "publicationYear": 2016, "publicationDate": "2016-10", "type": "journal-article", "publisher": "Institute of Electrical and Electronics Engineers (IEEE)", "containerTitle": "IEEE Internet of Things Journal", "volume": "3", "issue": "5", "page": "637-646", "issn": "2327-4662", "isbn": null, "authors": "Weisong Shi, Jie Cao, Quan Zhang, Youhuizi Li, Lanyu Xu", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 7338, "referenceCount": 40, "isOpenAccess": true, "licenseUrl": "https://ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1109/jiot.2016.2579198", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1063/1.103561", "doi": "10.1063/1.103561", "title": "Silicon quantum wire array fabrication by electrochemical and chemical dissolution of wafers", "publicationYear": 1990, "publicationDate": "1990-09-03", "type": "journal-article", "publisher": "AIP Publishing", "containerTitle": "Applied Physics Letters", "volume": "57", "issue": "10", "page": "1046-1048", "issn": "0003-6951, 1077-3118", "isbn": null, "authors": "L. T. Canham", "authorCount": 1, "firstAuthorAffiliation": "Royal Signals and Radar Establishment, St. Andrews Road, Great Malvern, Worcestershire WR14 3PS, United Kingdom", "isReferencedByCount": 7314, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1063/1.103561", "pdfUrl": "https://pubs.aip.org/aip/apl/article-pdf/57/10/1046/18478329/1046_1_online.pdf", "abstract": "Indirect evidence is presented that free-standing Si quantum wires can be fabricated without the use of epitaxial deposition or lithography. The novel approach uses electrochemical and chemical dissolution steps to define networks of isolated wires out of bulk wafers. Mesoporous Si layers of high porosity exhibit visible (red) photoluminescence at room temperature, observable with the naked eye under &amp;lt;1 mW unfocused (&amp;lt;0.1 W cm−2) green or blue laser line excitation. This is attributed to dramatic two-dimensional quantum size effects which can produce emission far above the band gap of bulk crystalline Si.", "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1103/revmodphys.74.145", "doi": "10.1103/revmodphys.74.145", "title": "Quantum cryptography", "publicationYear": 2002, "publicationDate": "2002-03-08", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Reviews of Modern Physics", "volume": "74", "issue": "1", "page": "145-195", "issn": "0034-6861, 1539-0756", "isbn": null, "authors": "Nicolas Gisin, Grégoire Ribordy, Wolfgang Tittel, Hugo Zbinden", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 7272, "referenceCount": 184, "isOpenAccess": true, "licenseUrl": "http://link.aps.org/licenses/aps-default-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1103/revmodphys.74.145", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1103/physrevlett.95.226801", "doi": "10.1103/physrevlett.95.226801", "title": "Quantum Spin Hall Effect in Graphene", "publicationYear": 2005, "publicationDate": "2005-11-23", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Physical Review Letters", "volume": "95", "issue": "22", "page": null, "issn": "0031-9007, 1079-7114", "isbn": null, "authors": "C. L. Kane, E. J. Mele", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 7161, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": "http://link.aps.org/licenses/aps-default-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1103/physrevlett.95.226801", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1016/s0304-4165(89)80016-9", "doi": "10.1016/s0304-4165(89)80016-9", "title": "The relationship between the quantum yield of photosynthetic electron transport and quenching of chlorophyll fluorescence", "publicationYear": 1989, "publicationDate": "1989-01", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Biochimica et Biophysica Acta (BBA) - General Subjects", "volume": "990", "issue": "1", "page": "87-92", "issn": "0304-4165", "isbn": null, "authors": "Bernard Genty, Jean-Marie Briantais, Neil R. Baker", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 6977, "referenceCount": 22, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/s0304-4165(89)80016-9", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1021/cr00005a013", "doi": "10.1021/cr00005a013", "title": "A quantum theory of molecular structure and its applications", "publicationYear": 1991, "publicationDate": "1991-07-01", "type": "journal-article", "publisher": "American Chemical Society (ACS)", "containerTitle": "Chemical Reviews", "volume": "91", "issue": "5", "page": "893-928", "issn": "0009-2665, 1520-6890", "isbn": null, "authors": "Richard F. W. Bader", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 6905, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1021/cr00005a013", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1145/1721654.1721672", "doi": "10.1145/1721654.1721672", "title": "A view of cloud computing", "publicationYear": 2010, "publicationDate": "2010-04", "type": "journal-article", "publisher": "Association for Computing Machinery (ACM)", "containerTitle": "Communications of the ACM", "volume": "53", "issue": "4", "page": "50-58", "issn": "0001-0782, 1557-7317", "isbn": null, "authors": "Michael Armbrust, Armando Fox, Rean Griffith, Anthony D. Joseph, Randy Katz, Andy Konwinski, Gunho Lee, David Patterson, Ariel Rabkin, Ion Stoica, Matei Zaharia", "authorCount": 11, "firstAuthorAffiliation": "UC Berkeley Reliable Adaptive Distributed Systems Laboratory (RAD Lab)", "isReferencedByCount": 6822, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": "https://www.acm.org/publications/policies/copyright_policy#Background", "funderNames": "Division of Computer and Network Systems, University of California", "funderIds": "10.13039/100000144, 10.13039/100005595", "url": "https://doi.org/10.1145/1721654.1721672", "pdfUrl": null, "abstract": "Clearing the clouds away from the true potential and obstacles posed by this computing capability.", "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1103/physrevlett.69.2863", "doi": "10.1103/physrevlett.69.2863", "title": "Density matrix formulation for quantum renormalization groups", "publicationYear": 1992, "publicationDate": "1992-11-09", "type": "journal-article", "publisher": "American Physical Society (APS)", "containerTitle": "Physical Review Letters", "volume": "69", "issue": "19", "page": "2863-2866", "issn": "0031-9007", "isbn": null, "authors": "Steven R. White", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 6797, "referenceCount": 11, "isOpenAccess": true, "licenseUrl": "http://link.aps.org/licenses/aps-default-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1103/physrevlett.69.2863", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1038/s41586-019-1666-5", "doi": "10.1038/s41586-019-1666-5", "title": "Quantum supremacy using a programmable superconducting processor", "publicationYear": 2019, "publicationDate": "2019-10-24", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Nature", "volume": "574", "issue": "7779", "page": "505-510", "issn": "0028-0836, 1476-4687", "isbn": null, "authors": "Frank Arute, Kunal Arya, Ryan Babbush, Dave Bacon, Joseph C. Bardin, Rami Barends, Rupak Biswas, Sergio Boixo, Fernando G. S. L. Brandao, David A. Buell, Brian Burkett, Yu Chen, Zijun Chen, Ben Chiaro, Roberto Collins, William Courtney, Andrew Dunsworth, Edward Farhi, Brooks Foxen, Austin Fowler, Craig Gidney, Marissa Giustina, Rob Graff, Keith Guerin, Steve Habegger, Matthew P. Harrigan, Michael J. Hartmann, Alan Ho, Markus Hoffmann, Trent Huang, Travis S. Humble, Sergei V. Isakov, Evan Jeffrey, Zhang Jiang, Dvir Kafri, Kostyantyn Kechedzhi, Julian Kelly, Paul V. Klimov, Sergey Knysh, Alexander Korotkov, Fedor Kostritsa, David Landhuis, Mike Lindmark, Erik Lucero, Dmitry Lyakh, Salvatore Mandrà, Jarrod R. McClean, Matthew McEwen, Anthony Megrant, Xiao Mi, Kristel Michielsen, Masoud Mohseni, Josh Mutus, Ofer Naaman, Matthew Neeley, Charles Neill, Murphy Yuezhen Niu, Eric Ostby, Andre Petukhov, John C. Platt, Chris Quintana, Eleanor G. Rieffel, Pedram Roushan, Nicholas C. Rubin, Daniel Sank, Kevin J. Satzinger, Vadim Smelyanskiy, Kevin J. Sung, Matthew D. Trevithick, Amit Vainsencher, Benjamin Villalonga, Theodore White, Z. Jamie Yao, Ping Yeh, Adam Zalcman, Hartmut Neven, John M. Martinis", "authorCount": 77, "firstAuthorAffiliation": null, "isReferencedByCount": 6672, "referenceCount": 55, "isOpenAccess": true, "licenseUrl": "https://www.springernature.com/gp/researchers/text-and-data-mining", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1038/s41586-019-1666-5", "pdfUrl": "https://www.nature.com/articles/s41586-019-1666-5.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1126/science.1133734", "doi": "10.1126/science.1133734", "title": "Quantum Spin Hall Effect and Topological Phase Transition in HgTe Quantum Wells", "publicationYear": 2006, "publicationDate": "2006-12-15", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "314", "issue": "5806", "page": "1757-1761", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "B. Andrei Bernevig, Taylor L. Hughes, Shou-Cheng Zhang", "authorCount": 3, "firstAuthorAffiliation": "Department of Physics, Stanford University, Stanford, CA 94305, USA.", "isReferencedByCount": 6468, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.1133734", "pdfUrl": null, "abstract": "We show that the quantum spin Hall (QSH) effect, a state of matter with topological properties distinct from those of conventional insulators, can be realized in mercury telluride–cadmium telluride semiconductor quantum wells. When the thickness of the quantum well is varied, the electronic state changes from a normal to an “inverted” type at a critical thickness d c . We show that this transition is a topological quantum phase transition between a conventional insulating phase and a phase exhibiting the QSH effect with a single pair of helical edge states. We also discuss methods for experimental detection of the QSH effect.", "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1007/bf01608499", "doi": "10.1007/bf01608499", "title": "On the generators of quantum dynamical semigroups", "publicationYear": 1976, "publicationDate": "1976-06", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Communications in Mathematical Physics", "volume": "48", "issue": "2", "page": "119-130", "issn": "0010-3616, 1432-0916", "isbn": null, "authors": "G. Lindblad", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 6460, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "http://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/bf01608499", "pdfUrl": "http://link.springer.com/content/pdf/10.1007/BF01608499.pdf", "abstract": null, "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.1126/science.281.5385.2016", "doi": "10.1126/science.281.5385.2016", "title": "Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection", "publicationYear": 1998, "publicationDate": "1998-09-25", "type": "journal-article", "publisher": "American Association for the Advancement of Science (AAAS)", "containerTitle": "Science", "volume": "281", "issue": "5385", "page": "2016-2018", "issn": "0036-8075, 1095-9203", "isbn": null, "authors": "Warren C. W. Chan, Shuming Nie", "authorCount": 2, "firstAuthorAffiliation": "Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.", "isReferencedByCount": 6273, "referenceCount": 36, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1126/science.281.5385.2016", "pdfUrl": null, "abstract": "Highly luminescent semiconductor quantum dots (zinc sulfide–capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection. In comparison with organic dyes such as rhodamine, this class of luminescent labels is 20 times as bright, 100 times as stable against photobleaching, and one-third as wide in spectral linewidth. These nanometer-sized conjugates are water-soluble and biocompatible. Quantum dots that were labeled with the protein transferrin underwent receptor-mediated endocytosis in cultured HeLa cells, and those dots that were labeled with immunomolecules recognized specific antibodies or antigens.", "subject": null, "language": "en", "_run_id": "gfIJCMH8LKbnDMIB7", "_dataset_id": "ddoBlDbs2z6nCWTNT"}
{"paperId": "10.21275/sr24805160228", "doi": "10.21275/sr24805160228", "title": "Deep Learning - Based Diabetic Retinopathy Detection: A Survey on Deep Learning Architectures", "publicationYear": 2024, "publicationDate": "2024-08-05", "type": "journal-article", "publisher": "International Journal of Science and Research", "containerTitle": "International Journal of Science and Research (IJSR)", "volume": "13", "issue": "8", "page": "1049-1053", "issn": "2319-7064", "isbn": null, "authors": "Srinidhi G A", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.21275/sr24805160228", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.18178/ijlll.2024.10.1.479", "doi": "10.18178/ijlll.2024.10.1.479", "title": "Deep Chinese Teaching and Learning Model Based on Deep Learning", "publicationYear": 2024, "publicationDate": "2024", "type": "journal-article", "publisher": "EJournal Publishing", "containerTitle": "International Journal of Languages, Literature and Linguistics", "volume": "10", "issue": "1", "page": "32-35", "issn": "2382-6282, 2972-3108", "isbn": null, "authors": "Yipu Wang, Stuart Perrin", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.18178/ijlll.2024.10.1.479", "pdfUrl": null, "abstract": "Deep learning is a more situational and reflective way of learning that integrates complex knowledge and skills into intuitive thinking. As a language that closely combines sound, form and meaning, Chinese teaching and learning from the perspective of deep learning can help break through the limitations of the current teaching model that only focuses on certain language knowledge or cultural behaviors. This paper combines deep learning with international Chinese education, creates deep Chinese teaching and learning model including “four stages and ten steps”, and carries out practical application and teaching effect test. The results show that the deep Chinese teaching and learning model is conducive to improving students’ discourse presentation ability and comprehensive skills, cultivating the learners’ autonomous learning ability and intercultural communication competence, and strengthening the integration of language teaching and cultural teaching. At the same time, this model also has some limitations, need to be further adjusted and optimized.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.2139/ssrn.3193693", "doi": "10.2139/ssrn.3193693", "title": "AI, Machine Learning &amp; Deep Learning Risk Management &amp; Controls: Beyond Deep Learning and Generative Adversarial Networks: Model Risk Management in AI, Machine Learning &amp; Deep Learning", "publicationYear": 2018, "publicationDate": "2018", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "SSRN Electronic Journal", "volume": null, "issue": null, "page": null, "issn": "1556-5068", "isbn": null, "authors": "Yogesh Malhotra", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 9, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.3193693", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.48047/nq.2022.20.3.nq22955", "doi": "10.48047/nq.2022.20.3.nq22955", "title": "Performance Analysis of Extensional Deep Learning And Boosted Intensional Deep Learning Method", "publicationYear": 2023, "publicationDate": "2023-05-24", "type": "journal-article", "publisher": "Institute for Advanced Studies", "containerTitle": "neuroquantology", "volume": "20", "issue": "03", "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.48047/nq.2022.20.3.nq22955", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.4314/sajhe.v17i1.25201", "doi": "10.4314/sajhe.v17i1.25201", "title": "Deep learning? What deep learning?", "publicationYear": 2003, "publicationDate": "2003-01-01", "type": "journal-article", "publisher": "African Journals Online (AJOL)", "containerTitle": "South African Journal of Higher Education", "volume": "17", "issue": "1", "page": null, "issn": "1011-3487", "isbn": null, "authors": "C. M. Fourie", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.4314/sajhe.v17i1.25201", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.56028/aetr.16.1.500.2026", "doi": "10.56028/aetr.16.1.500.2026", "title": "Deep Reinforcement Learning: An Innovative Approach that Combines Deep Learning and Reinforcement Learning", "publicationYear": 2026, "publicationDate": "2026-03-10", "type": "journal-article", "publisher": "Madison Academic Press", "containerTitle": "Advances in Engineering Technology Research", "volume": "16", "issue": "1", "page": "500", "issn": "2790-1688", "isbn": null, "authors": "Yan Cui", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.56028/aetr.16.1.500.2026", "pdfUrl": "https://admin.madison-publishing.com/index.php/aetr/article/download/4773/4786", "abstract": "Deep reinforcement learning (DRL) has emerged as a transformative paradigm that integrates the powerful representation-learning capabilities of deep neural networks with the sequential decision-making framework of reinforcement learning. Building upon the foundations of value functions, policy optimization, and Markov decision processes, DRL enables agents to operate effectively in high-dimensional, nonlinear, and dynamic environments where traditional methods fall short. This article provides a comprehensive overview of the theoretical principles, core algorithms, and key enabling techniques—such as neural network architectures, experience replay, Deep Q-Networks, and policy-gradient approaches—that underpin modern DRL systems. In addition, the paper examines several prominent application domains, including gaming, robotics, autonomous driving, finance, and healthcare, highlighting how DRL facilitates adaptive control, long-term optimization, and human-centered interaction. Challenges such as sample inefficiency, limited interpretability, and safety concerns are discussed, alongside emerging directions including model-based RL, multimodal learning, transfer learning, and ethical considerations. Overall, this study underscores the substantial potential of deep reinforcement learning to advance artificial intelligence and provides insights into future research necessary to ensure reliable, efficient, and responsible deployment of DRL technologies.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.23917/jdl.v1i2.11224", "doi": "10.23917/jdl.v1i2.11224", "title": "Learning Innovation in Global Citizenship Education by Integrating Deep Learning Approach", "publicationYear": 2025, "publicationDate": "2025-10-31", "type": "journal-article", "publisher": "Universitas Muhammadiyah Surakarta", "containerTitle": "Journal of Deep Learning", "volume": null, "issue": null, "page": "203-210", "issn": "3110-7591", "isbn": null, "authors": "Sutrisno Sutrisno, Sunarto Sunarto, Dyah Mustikasari", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.23917/jdl.v1i2.11224", "pdfUrl": "https://journals2.ums.ac.id/jdl/article/download/11224/4568", "abstract": "Conventional learning methods in dealing with the complexity of dynamic and multidimensional global issues in learning global citizenship education are still ineffective, this can be seen from the low understanding and awareness of students in solving global issues that occur. This research aims to develop and test learning innovations by integrating deep learning approaches to improve students' understanding and participation in the context of global citizenship. The research method used was quantitative research with an experimental approach. The research subjects consisted of senior high school students in a sample school. The research instruments included questionnaires, comprehension tests, and observations used to measure the effectiveness of learning before and after the application of the deep learning approach. The collected data were analyzed using descriptive and inferential statistics to assess the improvement of learning outcomes. The results showed that the integration of deep learning approach in global citizenship education significantly improved students' concept understanding, critical thinking skills, and learning motivation. Students become more active and able to connect civic education materials with contemporary global issues more deeply. The implication of this research finding is that the application of deep learning technology can be an effective innovative strategy in developing global citizenship education that is adaptive and responsive to the challenges of the times. This encourages educators to utilize artificial intelligence technology in the learning process to create a more interactive and meaningful learning experience.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.62945/deeplearning.v1i1.211", "doi": "10.62945/deeplearning.v1i1.211", "title": "Improving Student Learning Outcomes in Fiqh Learning through the Student Problem Based Learning Model at MI Nurul Jihad", "publicationYear": 2025, "publicationDate": "2025-01-31", "type": "journal-article", "publisher": "Mandailing Global Edukasia", "containerTitle": "DEEP LEARNING: Journal of Educational Research", "volume": "1", "issue": "1", "page": "159-171", "issn": "3090-1502", "isbn": null, "authors": "Muzanni, Najla", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.62945/deeplearning.v1i1.211", "pdfUrl": "https://ejournal.mgedukasia.or.id/index.php/deeplearning/article/download/211/205", "abstract": "This study aims to improve the learning motivation of fifth grade students of MI Nurul Jihad in the subject of Fiqh through the application of the Problem Based Learning learning model. The background of the study identified that the learning process tends to focus on memorization, does not involve students actively, and results in low learning motivation. This condition is influenced by limited facilities and infrastructure, lack of mastery of science and technology by teachers, and low student interest in learning. Based on these problems, this classroom action research was formulated to answer the question: \"Can the use of the Problem Based Learning learning model improve students' learning motivation in the field of Fiqh studies of fifth grade MI Nurul Jihad?\" This study uses the Classroom Action Research method that focuses on the implementation of the Problem Based Learning model. Data were collected through tests, observations, and documentation, then analyzed descriptively qualitatively. The results of initial observations showed low student participation and learning outcomes, where only 66.7% of students (10 out of 15) achieved completion with an average score of 65.33. After implementing cycle I of the PBL model, there was a significant increase in student learning outcomes, with 80.0% of students (12 out of 15) achieving completion and the class average score increasing to 75.0.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.62945/deeplearning.v1i2.223", "doi": "10.62945/deeplearning.v1i2.223", "title": "Implementation of Problem Based Learning Model to Improve Learning Outcomes at SD Negeri Lawe Bulan", "publicationYear": 2025, "publicationDate": "2025-04-30", "type": "journal-article", "publisher": "Mandailing Global Edukasia", "containerTitle": "DEEP LEARNING: Journal of Educational Research", "volume": "1", "issue": "2", "page": "44-54", "issn": "3090-1502", "isbn": null, "authors": "Irma Fitri Suriani", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.62945/deeplearning.v1i2.223", "pdfUrl": "https://ejournal.mgedukasia.or.id/index.php/deeplearning/article/download/223/216", "abstract": "This classroom action research aims to improve the learning outcomes of fourth-grade students at SD Negeri Lawe Bulan in the topic of \"Approaching Puberty\" through the implementation of the Problem Based Learning (PBL) model. The study is motivated by the low academic performance observed in students, which fell below the Minimum Competency Standard. The conventional and monotonous learning methods were identified as contributing factors to students’ lack of engagement and understanding, particularly in Islamic religious education, where concepts are often delivered as rote memorization. The research was conducted in two cycles, each consisting of planning, action, observation, and reflection. Data collection techniques included tests, observations, and documentation. The findings indicate that PBL significantly enhanced students' critical thinking, engagement, and learning outcomes. In Cycle I, the average student score was 77.92, while in Cycle II, it increased to 86.28. Student and teacher activities during learning also improved from \"good\" to \"very good\" qualifications. The PBL model, by incorporating real-life problems and collaborative learning, created a more meaningful learning experience and promoted students’ active participation. This approach helped students better understand the physical and emotional changes associated with puberty and encouraged them to take responsibility for their learning. The results of this study demonstrate that PBL is an effective instructional model to foster deeper comprehension, critical thinking skills, and improved academic performance in religious education. It also supports the development of independent, creative, and responsible learners.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.55248/gengpi.6.0425.16118", "doi": "10.55248/gengpi.6.0425.16118", "title": "Distraction Detection for Vehicle Drivers Using Deep Learning Techniques: A Review of Advanced Deep Learning Techniques", "publicationYear": 2025, "publicationDate": "2025-04", "type": "journal-article", "publisher": "Genesis Global Publication", "containerTitle": "International Journal of Research Publication and Reviews", "volume": "6", "issue": "4", "page": "16612-16618", "issn": "2582-7421", "isbn": null, "authors": "Yash Pansare, Lav Parab, Atharva Patil", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.55248/gengpi.6.0425.16118", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.23917/jdl.v1i2.11572", "doi": "10.23917/jdl.v1i2.11572", "title": "Deep Learning-Based Learning Strategies in Realizing Meaningful, Critical, and Enjoyable Learning", "publicationYear": 2025, "publicationDate": "2025-09-26", "type": "journal-article", "publisher": "Universitas Muhammadiyah Surakarta", "containerTitle": "Journal of Deep Learning", "volume": null, "issue": null, "page": "179-187", "issn": "3110-7591", "isbn": null, "authors": "Rizwatul Hasanah, Harun Joko Prayitno, Suni Tuti, Sarilan Sarilan, Velandani Prakoso", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.23917/jdl.v1i2.11572", "pdfUrl": "https://journals2.ums.ac.id/jdl/article/download/11572/4360", "abstract": "This study aims to examine the form and scope of the application of Deep Learning in the Vocational High School (SMK), especially at SMK Mantingan, through a literature study approach. Deep Learning, as part of artificial intelligence, has great potential in the world of vocational education, especially in supporting technology-based learning and improving student competencies in the digital field. This study relies on various literature sources such as scientific journals, books, articles, and relevant documents to examine the concepts, applications, and challenges faced in the integration of Deep Learning in vocational schools. The results of the study show that although the application of Deep Learning in vocational schools, including at SMK Mantingan, is still relatively new and limited, there are great opportunities for development in project-based learning and improving students' digital literacy. The scope of implementation includes the introduction of basic concepts, the use of supporting software, and the use of simple models for educational purposes. This study recommends the need for teacher training, the provision of adequate infrastructure, and collaboration with higher education institutions or industry to expand the application of this technology in vocational schools.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.5210/fm.v24i2.8237", "doi": "10.5210/fm.v24i2.8237", "title": "Down the deep rabbit hole: Untangling deep learning from machine learning and artificial intelligence", "publicationYear": 2019, "publicationDate": "2019-02-01", "type": "journal-article", "publisher": "University of Illinois Libraries", "containerTitle": "First Monday", "volume": null, "issue": null, "page": null, "issn": "1396-0466", "isbn": null, "authors": "Niel Chah", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5210/fm.v24i2.8237", "pdfUrl": null, "abstract": "Interest in deep learning, machine learning, and artificial intelligence from industry and the general public has reached a fever pitch recently. However, these terms are frequently misused, confused, and conflated. This paper serves as a non-technical guide for those interested in a high-level understanding of these increasingly influential notions by exploring briefly the historical context of deep learning, its public presence, and growing concerns over the limitations of these techniques. As a first step, artificial intelligence and machine learning are defined. Next, an overview of the historical background of deep learning reveals its wide scope and deep roots. A case study of a major deep learning implementation is presented in order to analyze public perceptions shaped by companies focused on technology. Finally, a review of deep learning limitations illustrates systemic vulnerabilities and a growing sense of concern over these systems.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.62945/deeplearning.v1i2.221", "doi": "10.62945/deeplearning.v1i2.221", "title": "Conscious Learning Model in Improving Students' Learning Outcomes: A Classroom Action Research at MIN 5 Bone", "publicationYear": 2025, "publicationDate": "2025-05-16", "type": "journal-article", "publisher": "Mandailing Global Edukasia", "containerTitle": "DEEP LEARNING: Journal of Educational Research", "volume": "1", "issue": "2", "page": "19-31", "issn": "3090-1502", "isbn": null, "authors": "Ferdiansyah, Nahirah", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.62945/deeplearning.v1i2.221", "pdfUrl": "https://ejournal.mgedukasia.or.id/index.php/deeplearning/article/download/221/214", "abstract": "In the learning process, there are still many teachers who use the direct learning model with the lecture method, this makes students bored and bored during the learning process, so teachers need to vary the fun learning model according to learning so that students do not feel bored and bored. This study aims to examine the implementation of the Conscious Learning Model in improving students' learning outcomes through Classroom Action Research (CAR). The Conscious Learning Model emphasizes active student engagement, awareness in learning processes, and metacognitive strategies that enable learners to understand not only what they learn but how they learn. The research was conducted in two cycles, each consisting of planning, action, observation, and reflection stages. The subjects of this study were students from a fifth-grade class at a public elementary school in Indonesia. Data were collected through observation, tests, and documentation to measure changes in student learning outcomes and engagement. The results indicated a significant improvement in student learning outcomes after the implementation of the Conscious Learning Model. In the first cycle, students showed moderate improvement, with several still struggling to articulate learning goals and monitor their understanding. In the second cycle, however, there was a marked increase in students' ability to plan, evaluate, and regulate their learning processes. This was evidenced by higher test scores, increased participation in classroom discussions, and more reflective learning behaviors. The study concludes that the Conscious Learning Model is an effective approach to enhance student learning outcomes, particularly when applied consistently with supportive instructional strategies and reflective teaching practices. The implications of this research suggest that integrating conscious and reflective learning activities into daily instruction can foster more meaningful and self-directed learning experiences for students.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.7557/18.6804", "doi": "10.7557/18.6804", "title": "Questionable Practices in Methodological Deep Learning Research", "publicationYear": 2023, "publicationDate": "2023-01-23", "type": "journal-article", "publisher": "UiT The Arctic University of Norway", "containerTitle": "Proceedings of the Northern Lights Deep Learning Workshop", "volume": "4", "issue": null, "page": null, "issn": "2703-6928", "isbn": null, "authors": "Daniel J. Trosten", "authorCount": 1, "firstAuthorAffiliation": "UiT The Arctic University of Norway", "isReferencedByCount": 2, "referenceCount": 19, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.7557/18.6804", "pdfUrl": "https://septentrio.uit.no/index.php/nldl/article/download/6804/7017", "abstract": "Evaluation of new methodology in deep learning (DL) research is typically done by reporting point estimates of a few performance metrics, calculated from a single training run. This paper argues that this frequently used evaluation protocol in DL is fundamentally flawed -- presenting 8 questionable practices that are widely adopted in the evaluation of new DL methods. The questionable practices are derived from violations of statistical principles of the scientific method, and from Hansson's definition of pseudoscience. A survey of recent publications from a top-tier DL conference indicates the widespread adoption of these practices in state-of-the-art DL research. Lastly, arguments in favor of the questionable practices, possible reasons for their adoption, and measures that have been taken to remove them, are discussed.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.33548/scientia849", "doi": "10.33548/scientia849", "title": "Seeing Deep into the Lungs with Deep Learning", "publicationYear": 2022, "publicationDate": "2022", "type": "journal-article", "publisher": "Science Diffusion Ltd", "containerTitle": "Scientia", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Yiqiao Yin", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.33548/scientia849", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.23917/jdl.v1i1.11246", "doi": "10.23917/jdl.v1i1.11246", "title": "Deep Learning vs Differentiated Learning: Learning Innovation in Islamic Boarding School-Based Middle Schools", "publicationYear": 2025, "publicationDate": "2025-06-24", "type": "journal-article", "publisher": "Universitas Muhammadiyah Surakarta", "containerTitle": "Journal of Deep Learning", "volume": null, "issue": null, "page": "57-68", "issn": "3110-7591", "isbn": null, "authors": "Murwanto Setyo Nugroho, Harun Joko Prayitno, Koesoemo Ratih, Muhammad Samsudin", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.23917/jdl.v1i1.11246", "pdfUrl": "https://journals2.ums.ac.id/jdl/article/download/11246/3631", "abstract": "This study aims to examine the implementation of deep learning and differentiated learning approaches in Islamic boarding school-based junior high schools (SMP) in order to improve the quality of meaningful, contextual, and humanistic learning. Using a descriptive qualitative approach, data were collected through in-depth interviews, classroom observations, and documentation studies in three Islamic boarding school junior high schools that integrate national and religious curricula. The results of the study indicate that learning strategies such as project-based learning, reflective discussions, and collaborative activities are effective in building conceptual understanding and spiritual values ​​of students. Differentiated learning enables the creation of an inclusive learning environment by adjusting content, processes, and products according to students' learning profiles. Implementation challenges arise in terms of time constraints, dual curriculum burdens, and teacher professional readiness. Authentic project-based and portfolio-based evaluations are more relevant in measuring cognitive, affective, and spiritual competencies holistically. This study recommends the need for educational policies that are more adaptive to the characteristics of Islamic boarding schools, including contextual teacher training, curriculum flexibility, and an inclusive and sustainable evaluation system. These findings confirm that deep learning and differentiated learning have great potential in transforming Islamic boarding school education towards 21st-century learning that is more humanistic, reflective, and transformative.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.12739/nwsa.2022.17.4.2a0189", "doi": "10.12739/nwsa.2022.17.4.2a0189", "title": "OBJECT RECOGNITION WITH DEEP LEARNING AND MACHINE LEARNING METHODS", "publicationYear": 2022, "publicationDate": "2022-10-29", "type": "journal-article", "publisher": "NWSA Academic Journals", "containerTitle": "NWSA Academic Journals", "volume": "17", "issue": "4", "page": "54-61", "issn": "1308-7231", "isbn": null, "authors": "İsmail Akgül, Yıldız Aydın", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.12739/nwsa.2022.17.4.2a0189", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.24135/rangahau-aranga.v1i1.32", "doi": "10.24135/rangahau-aranga.v1i1.32", "title": "From machine learning to deep learning: experimental comparison of machine learning and deep learning for skin cancer image segmentation", "publicationYear": 2022, "publicationDate": "2022-04-11", "type": "journal-article", "publisher": "Auckland University of Technology (AUT) Library", "containerTitle": "Rangahau Aranga: AUT Graduate Review", "volume": "1", "issue": "1", "page": null, "issn": "2815-8202", "isbn": null, "authors": "Ranpreet Kaur", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 7, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.24135/rangahau-aranga.v1i1.32", "pdfUrl": "https://ojs.aut.ac.nz/rangahau-aranga/1/article/download/32/15", "abstract": "Skin lesion analysis is a tedious and challenging task, thus, in this research the suitability of employing machine learning or deep learning approaches for automatic lesion segmentation on dermoscopic skin cancer images is determined. The segmented region can assist clinical experts in understanding the complex lesion structure and internal pattern to find the correct skin cancer type for its early diagnosis and prevention. In this study, I present two methodologies for performing lesion segmentation: machine learning-based optimized K-means with Firefly Algorithm (FA) and Convolutional Neural Network (CNN). In the first model, the FA is hybridized with K-means clustering based on the novel average intensity fitness function to optimize the segmentation map. It is observed in the experimental results that the K-means algorithm may lead to poor results due to the wrong selection of initial centroid value, thus FA is hybridized into it to improve the performance. The second model is an enhanced encoder-decoder-based CNN framework implemented in an end-to-end fashion. These two models are compared to understand whether machine learning or deep learning is suitable to perform medical image segmentation based on a few performance metrics such as accuracy, Intersection over Union (IoU), and DICE index. These methods are evaluated and compared on two benchmark datasets provided by the International Skin Imaging Collaboration (ISIC) named ISIC 2016 [1] and ISIC 2017 [2]. Experimental results showed that the CNN model outperformed the machine learning model with an accuracy difference of 7.98% on ISIC 2016, and 7.32% on ISIC 2017. I concluded from the experimental findings that the deep learning model is more accurate and efficient in segmenting the lesion area as compared to the machine learning model. Thus, findings from this experimental work will be considered for the design of an automatic classification system by incorporating a deep learning-based segmentation approach as a pre-processing step.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.62945/deeplearning.v1i1.202", "doi": "10.62945/deeplearning.v1i1.202", "title": "Small Group Discussion Strategies Reviewed to Improve Student Learning Outcomes in Civics Learning at MI Sultan Agung", "publicationYear": 2025, "publicationDate": "2025-01-31", "type": "journal-article", "publisher": "Mandailing Global Edukasia", "containerTitle": "DEEP LEARNING: Journal of Educational Research", "volume": "1", "issue": "1", "page": "58-66", "issn": "3090-1502", "isbn": null, "authors": "Wahyu Rustyaningsih", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.62945/deeplearning.v1i1.202", "pdfUrl": "https://ejournal.mgedukasia.or.id/index.php/deeplearning/article/download/202/196", "abstract": "This study aims to examine the effectiveness of small group learning strategies in improving student learning outcomes in Civics Education at MI Sultan Agung. Civics, as a subject, plays a crucial role in shaping students' character, sense of responsibility, and awareness of democratic values. However, traditional teaching methods often result in passive student participation and low academic performance. To address this issue, this research implemented a classroom action research (CAR) approach consisting of two cycles, each comprising planning, action, observation, and reflection. The subjects of the study were fifth-grade students at MI Sultan Agung, totaling 28 participants. Data collection techniques included observation, tests, and documentation. The findings indicate a significant improvement in student learning outcomes after applying small group learning strategies. In the first cycle, the average student learning outcome reached 68.21, with 60.71% of students achieving the minimum mastery criterion (MMC). In the second cycle, the average score increased to 82.14, with 89.29% of students achieving the MMC. Furthermore, student engagement and participation in the learning process showed marked improvement, indicating that small group strategies promote collaboration, active learning, and critical thinking. These results support the conclusion that small group learning is an effective pedagogical approach for enhancing both cognitive and affective learning outcomes in Civics Education. This study contributes to the growing body of research advocating for student-centered learning environments and highlights the importance of interactive teaching methods in primary education. The implementation of small group learning is recommended as a sustainable strategy to improve educational quality, particularly in the context of civic education, where active student involvement is essential. Future research may explore the long-term impact of this strategy and its application across different subjects and educational settings.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.62945/deeplearning.v1i1.209", "doi": "10.62945/deeplearning.v1i1.209", "title": "The Use of Domino Card Media to Improve Student Learning Outcomes in Natural Science Learning at MIS Mawu", "publicationYear": 2025, "publicationDate": "2025-01-31", "type": "journal-article", "publisher": "Mandailing Global Edukasia", "containerTitle": "DEEP LEARNING: Journal of Educational Research", "volume": "1", "issue": "1", "page": "134-145", "issn": "3090-1502", "isbn": null, "authors": "Nurmalah, Juhraeni", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.62945/deeplearning.v1i1.209", "pdfUrl": "https://ejournal.mgedukasia.or.id/index.php/deeplearning/article/download/209/203", "abstract": "The results of students' science learning are still very low when viewed from the results of daily tests that have been held four times, namely the average is 6.45, this means that it has not met the KKM for science subjects, which is 6.7. The factors causing low student learning outcomes are the teaching methods applied by teachers tend not to activate students, teachers never use media during learning so that students are not interested and not motivated to participate in learning. To solve the above problems, researchers use domino card media in learning. This study aims to determine the impact of using domino card media on improving the science learning outcomes of class III students of MIS Mawu, Ambalawi District, Bima Regency in the 2022/2023 academic year. The method used in this study is classroom action research. PTK is action research carried out with the aim of improving the quality of learning practices in the classroom. The subjects in this study were 39 class III students of MIS Mawu. The type of data used in this study is quantitative data. Where quantitative data is data obtained from student learning outcome data for each evaluation. Data was collected using a learning outcome test. The results of the study showed that the average student learning outcomes in cycle I were 65.00 and had not met the KKM for science subjects and in cycle II the average student learning outcomes increased to 75.12 and had met the KKM for science subjects. Thus, it can be concluded that the use of domino card media can improve the science learning outcomes of class III students of MIS Mawu, Ambalawi District, Bima Regency in the 2022/2023 academic year.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.62945/deeplearning.v1i1.196", "doi": "10.62945/deeplearning.v1i1.196", "title": "Improving Student Learning Motivation in Islamic Education Learning Using an Activity-Based Approach at SD Negeri Inpres Baralau", "publicationYear": 2025, "publicationDate": "2025-01-31", "type": "journal-article", "publisher": "Mandailing Global Edukasia", "containerTitle": "DEEP LEARNING: Journal of Educational Research", "volume": "1", "issue": "1", "page": "1-12", "issn": "3090-1502", "isbn": null, "authors": "Sri Ernawati", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.62945/deeplearning.v1i1.196", "pdfUrl": "https://ejournal.mgedukasia.or.id/index.php/deeplearning/article/download/196/190", "abstract": "This study investigates the effectiveness of an activity-based approach in enhancing students' learning motivation in Islamic Education at SD Negeri Inpres Baralau. Learning motivation is a critical factor that significantly influences students’ academic success, particularly in religious education where engagement can be challenging due to traditional and passive instructional methods. The research employed a classroom action research design conducted in two cycles, each consisting of planning, implementation, observation, and reflection stages. Data were collected through observation sheets, student questionnaires, and teacher interviews to triangulate findings. The participants involved were 32 students in Grade V during the 2024/2025 academic year. The findings revealed a marked improvement in students’ motivation following the implementation of activity-based learning strategies, including group discussions, role-playing, games, and creative project assignments related to Islamic values. Quantitative data showed a significant increase in students’ motivation scores, rising from an average of 62.3 in the pre-cycle to 76.8 in the first cycle and 85.4 in the second cycle. Qualitative observations supported these results, indicating higher levels of enthusiasm, participation, and sustained attention during lessons. This research highlights that integrating interactive and student-centered learning activities into Islamic Education can foster a more engaging and motivating learning environment. The study recommends adopting activity-based approaches in primary religious education to cultivate not only students’ interest but also a deeper understanding and internalization of Islamic values. These findings are relevant for educators, policymakers, and curriculum developers aiming to improve educational practices in faith-based learning contexts. Future research may explore the long-term impact of such approaches across different educational levels and cultural settings.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.62945/deeplearning.v1i1.208", "doi": "10.62945/deeplearning.v1i1.208", "title": "Cooperative Learning Strategy to Improve Student Learning Outcomes on the Theme of Always Saving Energy at MI Nurul Ihsan", "publicationYear": 2025, "publicationDate": "2025-01-31", "type": "journal-article", "publisher": "Mandailing Global Edukasia", "containerTitle": "DEEP LEARNING: Journal of Educational Research", "volume": "1", "issue": "1", "page": "121-133", "issn": "3090-1502", "isbn": null, "authors": "Haryati", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.62945/deeplearning.v1i1.208", "pdfUrl": "https://ejournal.mgedukasia.or.id/index.php/deeplearning/article/download/208/202", "abstract": "This study investigates the effectiveness of domino card media in improving science learning outcomes for students at MIS Mawu. Recognizing the limitations of traditional, passive learning methods in fostering deep understanding and engagement in science, this research explores the potential of an interactive and collaborative learning tool. Domino cards, designed to connect various scientific concepts, terms, or processes, were implemented as a pedagogical intervention. The study examines the impact of this medium on student engagement, collaborative learning skills, critical thinking abilities, and ultimately, their academic achievement in Ilmu Pengetahuan Alam (Natural Science). Data was collected through [mention data collection methods if specified in a full paper, e.g., pre- and post-tests, observations, student feedback]. The findings of this research aim to provide empirical evidence on the efficacy of domino card media as a tool for enhancing science education in the specific context of MIS Mawu. The results of this study [mention key findings if specified in a full paper, e.g., demonstrated a statistically significant improvement in student test scores, increased student engagement during lessons, enhanced collaborative problem-solving skills]. These findings suggest that the application of domino card media offers a valuable and engaging approach to teaching science, promoting active learning, collaboration, and critical thinking among students at MIS Mawu. The interactive and visual nature of the domino cards facilitated a deeper understanding of interconnected scientific concepts and catered to diverse learning styles. This research contributes to the growing body of literature on innovative teaching methodologies in science education and provides practical insights for educators seeking to enhance student learning outcomes through the use of engaging and hands-on media.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.7557/18.6801", "doi": "10.7557/18.6801", "title": "RIDDLE: Rule Induction with Deep Learning", "publicationYear": 2023, "publicationDate": "2023-01-23", "type": "journal-article", "publisher": "UiT The Arctic University of Norway", "containerTitle": "Proceedings of the Northern Lights Deep Learning Workshop", "volume": "4", "issue": null, "page": null, "issn": "2703-6928", "isbn": null, "authors": "Cosimo Persia, Ricardo Guimarães", "authorCount": 2, "firstAuthorAffiliation": "University of Bergen", "isReferencedByCount": 1, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.7557/18.6801", "pdfUrl": "https://septentrio.uit.no/index.php/nldl/article/download/6801/7016", "abstract": "Numerous applications rely on the efficiency of Deep Learning models to address complex classification tasks for critical decisions-making. However, we may not know how each feature in these models contributes towards the prediction. In contrast, Rule Induction algorithms provide an interpretable way to extract patterns from data, but traditional approaches suffer in terms of scalability. In this work, we bridge Deep Learning and Rule Induction and define the RIDDLE (Rule Induction with Deep Learning) architecture. We show that RIDDLE has state-of-the-art performance in Rule Induction via an empirical evaluation.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.2139/ssrn.3562976", "doi": "10.2139/ssrn.3562976", "title": "Deep Learning in diverse Computing and Network Applications Student Admission Predictor using Deep Learning", "publicationYear": 2020, "publicationDate": "2020", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "SSRN Electronic Journal", "volume": null, "issue": null, "page": null, "issn": "1556-5068", "isbn": null, "authors": "P. Nandal", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2139/ssrn.3562976", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.23917/jdl.v1i2.11969", "doi": "10.23917/jdl.v1i2.11969", "title": "Designing Mathematics Teaching through Deep Learning Pedagogy: Toward Meaningful, Mindful, and Joyful Learning", "publicationYear": 2025, "publicationDate": "2025-10-31", "type": "journal-article", "publisher": "Universitas Muhammadiyah Surakarta", "containerTitle": "Journal of Deep Learning", "volume": null, "issue": null, "page": "188-202", "issn": "3110-7591", "isbn": null, "authors": "Torang Siregar, Ahmad Fauzan, Yerizon Yerizon, Syafriandi Syafriandi", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.23917/jdl.v1i2.11969", "pdfUrl": "https://journals2.ums.ac.id/jdl/article/download/11969/4567", "abstract": "Mathematics education in the 21st century requires an approach that focuses not only on procedural mastery but also on deep conceptual understanding, critical thinking skills, and the ability to transfer knowledge across various life contexts. This article discusses the design of mathematics learning based on a deep learning approach not in the context of artificial intelligence, but as a pedagogical approach integrating three core principles: meaningful, mindful, and joyful. Meaningful learning is built through contextual activities and open-ended problems that connect mathematical concepts to real-world situations. Reflective and process-aware learning is facilitated through discussion, metacognitive reflection, and evaluation. Meanwhile, a joyful learning environment is created through active participation, open exploration, and recognition of diverse student thinking styles. The theoretical framework includes constructivism, transfer theory, metacognition, and process-based assessment. The implementation of this approach requires a transformation of the teacher's role into a facilitator, a flexible and meaning-oriented curriculum, and a supportive, collaborative learning environment. It is concluded that the deep learning approach, through the principles of meaningful, mindful, and joyful learning, can enhance student engagement, deepen understanding, and foster a positive attitude toward mathematics.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.21275/sr231023115126", "doi": "10.21275/sr231023115126", "title": "Machine Learning and Deep Learning Approaches for Cybersecurity: A Review", "publicationYear": 2023, "publicationDate": "2023-10-05", "type": "journal-article", "publisher": "International Journal of Science and Research", "containerTitle": "International Journal of Science and Research (IJSR)", "volume": "12", "issue": "10", "page": "1706-1710", "issn": "2319-7064", "isbn": null, "authors": "Migul Jain", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.21275/sr231023115126", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.56452/7-4-243", "doi": "10.56452/7-4-243", "title": "\"Deep Non-Parametic Learning Architecture: Performance Analysis Of Deep Learning Architecture\"", "publicationYear": 2023, "publicationDate": "2023", "type": "journal-article", "publisher": "Kalahari Journals", "containerTitle": "International Journal of Mechanical  Engineering", "volume": "8", "issue": null, "page": null, "issn": "0974-5823", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.56452/7-4-243", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.33140/amlai.03.02.04", "doi": "10.33140/amlai.03.02.04", "title": "Straight Forward Constructive Deep Learning Neural Network (SFC-DLNN) Algorithm", "publicationYear": 2022, "publicationDate": "2022-08-27", "type": "journal-article", "publisher": "Opast Group LLC", "containerTitle": "Advances in Machine Learning &amp; Artificial Intelligence", "volume": "3", "issue": "2", "page": null, "issn": "2769-545X", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.33140/amlai.03.02.04", "pdfUrl": null, "abstract": "Straight Forward Constructive Deep Learning Neural Network (SFC-DLNN) algorithm is a new architecturebased algorithm for artificial neural networks. Rather than simply adjusting the weights in a fixed topology network, SFC-DLNN starts with a minimal topology (perceptron), then builds up their network by gradually trains and adds new nodes one by one, creating multiple layers’ network. Once a unit has been added to the network, the weights of the new architecture are generated. This unit then stands as a permanent detector of features in the network, and a more complex feature space is then created where the data is likely to be linearly separable. The SFC-DLNN algorithm has many advantages over existing ones: it has good learning speed, the network determines its topology size, and the structures it has built is retained after the training stage. We obtain from our built model (SFC-DLNN) an accuracy and specificity of 83:5% from a simulated data set using the uniform distribution. This is not the best but is enough to approve the model prediction capacity", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.62945/deeplearning.v1i1.205", "doi": "10.62945/deeplearning.v1i1.205", "title": "Improving Understanding and Attitude of Gratitude Using Project Based Learning Model in Islamic Education Learning at SMP Negeri 1 Barumun Baru", "publicationYear": 2025, "publicationDate": "2025-01-31", "type": "journal-article", "publisher": "Mandailing Global Edukasia", "containerTitle": "DEEP LEARNING: Journal of Educational Research", "volume": "1", "issue": "1", "page": "94-106", "issn": "3090-1502", "isbn": null, "authors": "Hayatunnisah Nst", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.62945/deeplearning.v1i1.205", "pdfUrl": "https://ejournal.mgedukasia.or.id/index.php/deeplearning/article/download/205/199", "abstract": "This study aims to improve student learning outcomes in Islamic religious education learning using Project Based Learning. This study is a classroom action research that uses four steps, namely planning, action, observation and reflection. The subjects of this study were junior high school students. The data for this study were obtained using test and observation techniques. Tests are used to measure learning outcomes and observations are used to analyze teacher and student learning activities. The data analysis technique used in this study is descriptive statistics by comparing the results obtained with indicators of research success. The results of the study indicate that Project Based Learning can improve student learning outcomes in Islamic religious education learning. This can be seen from the increase in the percentage of student learning completion in each cycle with details of the pre-cycle 48.71%, the first cycle 65.39% and in the second cycle it increased to 89.76%. Thus, the use of Project Based Learning can be used as an alternative to improve student learning outcomes in Islamic religious education learning.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.34218/ijaidl_02_02_001", "doi": "10.34218/ijaidl_02_02_001", "title": "FEATURE SELECTION AND DEEP LEARNING MODEL FOR AIR QUALITY PREDICTION", "publicationYear": 2025, "publicationDate": "2025-12-03", "type": "journal-article", "publisher": "IAEME Publication", "containerTitle": "INTERNATIONAL JOURNAL OF ARTIFICIAL INTELLIGENCE AND DEEP LEARNING", "volume": "2", "issue": "2", "page": "1-11", "issn": null, "isbn": null, "authors": "Agastya Shrivastava", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.34218/ijaidl_02_02_001", "pdfUrl": "https://iaeme.com/MasterAdmin/Journal_uploads/IJAIDL/VOLUME_2_ISSUE_2/IJAIDL_02_02_001.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.36266/jcet/104", "doi": "10.36266/jcet/104", "title": "Deep Learning –An Overview", "publicationYear": 2019, "publicationDate": "2019-04-30", "type": "journal-article", "publisher": "Pubtexto", "containerTitle": "Journal of Current Engineering and Technology", "volume": "1", "issue": "1", "page": "1-4", "issn": "2582-1210, 2582-1210", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.36266/jcet/104", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.25077/jfu.15.4.372-381.2026", "doi": "10.25077/jfu.15.4.372-381.2026", "title": "Komparasi Deep Learning Convolutional Neural Network (CNN) dan Deep Learning CNN- Support Vector Machine (SVM) untuk Identifikasi Tumor Otak dan Payudara", "publicationYear": 2026, "publicationDate": "2026-08-01", "type": "journal-article", "publisher": "Universitas Andalas", "containerTitle": "Jurnal Fisika Unand", "volume": "15", "issue": "4", "page": "372-381", "issn": "2686-2433, 2302-8491", "isbn": null, "authors": "Siti Nur Khalisha, Pandji Triadyaksa, Ngurah Ayu Ketut Umiati", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.25077/jfu.15.4.372-381.2026", "pdfUrl": "https://jfu.fmipa.unand.ac.id/index.php/jfu/article/download/1771/1139", "abstract": "Identifikasi citra MRI tumor otak dan payudara merupakan aspek penting dalam pengembangan system computer aided diagnosis (CAD) yang akurat dan andal. Penelitian ini membandingkan kinerja model CNN tunggal berbasis Res-Net 50 dan model hibrida CNN-SVM dalam mengklasifikasikan berbagai jenis tumor melalui citra MRI. Metode penelitian meliputi akuisisi dataset citra MRI tumor otak dan payudara dari repositori daring Kaggle dan diproses melalui tahap pra-pemrosesan citra berupa resizing, konversi citra grayscale ke RGB, serta augmentasi data pada data training. Pada pendekatan CNN tunggal, Res-Net-50 digunakan sebagai pengklasifikasi end-to-end, sedangkan pada model hibrida CNN-SVM, fitur diekstraksi dari lapisan layer global pooling dan diklasifikasikan menggunakan SVM. Evaluasi kinerja dilakukan menggunkan confusion matrix dan chart perbandingan metrik kerja. Hasil penelitian menunjukkan bahwa kedua model mencapai akurasi 99,16 % pada klasifikasi tumor otak multi-kelas serta akurasi pada klasifikasi tumor payudara biner yaitu 98,02 %. Model CNN-SVM menunjukkan performa yang lebih stabil pada seluruh metrik kerja.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.64820/aepjmldl.11.41.46.122024", "doi": "10.64820/aepjmldl.11.41.46.122024", "title": "Uncertainty Estimation in Deep Learning: Methods and Applications", "publicationYear": 2024, "publicationDate": "2024-12-31", "type": "journal-article", "publisher": "Academic Edge Press", "containerTitle": "Journal of Machine Learning and Deep Learning", "volume": "1", "issue": "1", "page": "41-46", "issn": "2978-4336", "isbn": null, "authors": "Hina Batool, Tahir Abbas, Jamshaid Iqbal Janjua, Sadaqat Ali Ramay", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 23, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.64820/aepjmldl.11.41.46.122024", "pdfUrl": null, "abstract": "Uncertainty estimation in deep learning has emerged as a crucial area of research due to its significance in enhancing model reliability and decision-making in critical applications. This article explores various methods and applications of uncertainty estimation in deep learning, aiming to provide insights into its importance, methods, and potential impact. Through a comprehensive literature review and analysis, the study identifies key findings regarding the effectiveness, limitations, and ethical considerations associated with uncertainty estimation techniques. The results reveal the diverse range of methodologies employed, including Bayesian approaches, ensemble methods, and Monte Carlo sampling, each with its strengths and drawbacks. Furthermore, the article discusses the implications of uncertainty estimation in deep learning for fields such as healthcare, autonomous systems, and safety-critical domains. Overall, this study underscores the significance of uncertainty estimation in deep learning and provides valuable insights for researchers and practitioners in the field.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.1007/s10462-026-11560-3", "doi": "10.1007/s10462-026-11560-3", "title": "L.L. Thurstone, The law of effect and the dynamics of deep learning “a deep history of deep learning”", "publicationYear": 2026, "publicationDate": "2026-05-05", "type": "journal-article", "publisher": "Springer Science and Business Media LLC", "containerTitle": "Artificial Intelligence Review", "volume": "59", "issue": "8", "page": null, "issn": "1573-7462", "isbn": null, "authors": "Stephen Josè Hanson, Catherine Hanson", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 100, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/s10462-026-11560-3", "pdfUrl": "https://link.springer.com/content/pdf/10.1007/s10462-026-11560-3.pdf", "abstract": "Abstract Deep learning (DL), a variant of the neural network algorithms originally proposed in the early twentieth century, has resulted in a renaissance of artificial intelligence. Despite the growing dominance of DL networks, little is understood about the learning mechanism that makes these networks so effective across such a wide range of applications. Drawing on a century of psychological learning theory (e.g., LL Thurstone), an account is offered of the learning mechanism that may enable DL networks to perform so successfully across so many different tasks. Specifically, evidence is provided that learning in DL networks is fit best by a hyperbolic function. This function is independent of hyper/meta parameters–not a scaling function but a learning curve to a specific equilibrium, a function that also entails an autocatalytic mechanism through which complex structures, abstracted from sensory features, can in principle create and support cognitive function in both biological and artificial systems. Keywords: Learning theory, Deep Learning, hyperbolic, autocatalytic, AI, Thurstone", "subject": null, "language": "en", "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.18178/ijml.2026.16.1.1185", "doi": "10.18178/ijml.2026.16.1.1185", "title": "Forecasting Thai Agricultural Price: A Deep Learning Approach for Key Commodities", "publicationYear": 2026, "publicationDate": "2026", "type": "journal-article", "publisher": "EJournal Publishing", "containerTitle": "International Journal of Machine Learning", "volume": "16", "issue": null, "page": null, "issn": "2972-368X", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.18178/ijml.2026.16.1.1185", "pdfUrl": "https://www.ijml.org/vol16/IJML-V16N1-1185.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.23917/jdl.v2i1.14135", "doi": "10.23917/jdl.v2i1.14135", "title": "Deep Learning Approach: Potentials and Challenges in Indonesian Education", "publicationYear": 2026, "publicationDate": "2026-04-07", "type": "journal-article", "publisher": "Universitas Muhammadiyah Surakarta", "containerTitle": "Journal of Deep Learning", "volume": null, "issue": null, "page": "35-49", "issn": "3110-7591", "isbn": null, "authors": "Izza Hanifa Astono, Sri Endah Wahyuningsih, Sri Handayani", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.23917/jdl.v2i1.14135", "pdfUrl": "https://journals2.ums.ac.id/jdl/article/download/14135/5502", "abstract": "The transformation of education in the era of globalization and the Industrial Revolution 4.0 requires a paradigm shift from memorization-based learning toward approaches that emphasize deep understanding, active engagement, and the development of twenty-first century skills. The Deep Learning approach has emerged as a relevant pedagogical strategy to address these challenges in both academic and vocational education contexts. This study aims to comprehensively review the conceptual foundations, theoretical frameworks, empirical effectiveness, and the role of technology in implementing Deep Learning within Indonesia’s educational ecosystem. This research employs a literature review method by examining a range of scholarly articles and relevant policy documents, with a focus on deep learning practices, higher-order thinking development, and the integration of educational technologies. The findings indicate that the Deep Learning approach is supported by robust theoretical frameworks, such as the Deep Mathematical Thinking (DMT) model, which emphasizes conceptual connectivity, intrinsic motivation, and metacognition. Empirical evidence further demonstrates that the implementation of Deep Learning significantly enhances learning outcomes, cognitive engagement, and students’ conceptual understanding. Within vocational education, the integration of simulation technologies under the frameworks of Deep Learning and Joyful Learning has been shown to substantially improve students’ practical competencies and the overall quality of learning experiences. This study concludes that the integration of strong theoretical foundations, Deep Learning pedagogy, and adaptive learning technologies constitutes a key driver of effective and sustainable educational reform, aligned with global demands and future-oriented educational transformation.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.34218/ijnndl_03_01_002", "doi": "10.34218/ijnndl_03_01_002", "title": "A COMPREHENSIVE REVIEW OF TIME SERIES ANOMALY DETECTION: FROM TRADITIONAL METHODS TO DEEP LEARNING AND TRANSFER LEARNING APPROACHES", "publicationYear": 2026, "publicationDate": "2026-06-19", "type": "journal-article", "publisher": "IAEME Publication", "containerTitle": "INTERNATIONAL JOURNAL OF NEURAL NETWORKS AND DEEP LEARNING", "volume": "3", "issue": "1", "page": "7-19", "issn": null, "isbn": null, "authors": "V.K. Mixymol", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.34218/ijnndl_03_01_002", "pdfUrl": "https://iaeme.com/MasterAdmin/Journal_uploads/IJNNDL/VOLUME_3_ISSUE_1/IJNNDL_03_01_002.pdf", "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.22266/ijies2024.0229.64", "doi": "10.22266/ijies2024.0229.64", "title": "An Improved Deep Learning Based Test Case Prioritization Using Deep Reinforcement Learning", "publicationYear": 2024, "publicationDate": "2024-02-29", "type": "journal-article", "publisher": "The Intelligent Networks and Systems Society", "containerTitle": "International Journal of Intelligent Engineering and Systems", "volume": "17", "issue": "1", "page": "771-782", "issn": "2185-3118", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 8, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.22266/ijies2024.0229.64", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.53902/atr.2024.02.000502", "doi": "10.53902/atr.2024.02.000502", "title": "Spectral Deep Learning in Chronic Pulmonary Thromboembolism", "publicationYear": 2024, "publicationDate": "2024", "type": "journal-article", "publisher": "Stephy Publishers", "containerTitle": "Advancements in Teleradiology and Radiotherapy", "volume": "2", "issue": "1", "page": null, "issn": null, "isbn": null, "authors": "Henrique J Cirino", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.53902/atr.2024.02.000502", "pdfUrl": null, "abstract": "Pulmonary scintigraphy is considered a technique of choice in the evaluation of chronic pulmonary thromboembolism. Technical advancements in computed tomography as dual-energy (spectral) have allowed obtaining high quality images. As an example, a computed tomography as dual-energy patient case is shown, who underwent both scintigraphy and spectral deep learning not only was a lower radiation dose observed scintigraphy but also provided anatomical data on perfusion defect, essential for surgical planning and also evidenced other areas of perfusion alteration that were not clearly identified on V/Q scintigraphy. Thus, we bring this initial experience with the use of Spectral Deep Learning as a possibility to combine anatomical and perfusional assessment in the same acquisition, reducing dose and possible costs", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.55248/gengpi.06.1125.38111", "doi": "10.55248/gengpi.06.1125.38111", "title": "Plant disease detection using Machine learning and Deep learning", "publicationYear": 2025, "publicationDate": "2025-11", "type": "journal-article", "publisher": "Genesis Global Publication", "containerTitle": "International Journal of Research Publication and Reviews", "volume": "6", "issue": "11", "page": "2863-2868", "issn": "2582-7421", "isbn": null, "authors": "Likhith Simhadri", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.55248/gengpi.06.1125.38111", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.23917/jdl.v1i1.11157", "doi": "10.23917/jdl.v1i1.11157", "title": "Implementation of Deep Learning in Education: Towards Mindful, Meaningful, and Joyful Learning Experiences", "publicationYear": 2025, "publicationDate": "2025-06-19", "type": "journal-article", "publisher": "Universitas Muhammadiyah Surakarta", "containerTitle": "Journal of Deep Learning", "volume": null, "issue": null, "page": "47-56", "issn": "3110-7591", "isbn": null, "authors": "Lukie Masayu Andayanie, Muhammad Syahriandi Adhantoro, Eko Purnomo, Ganno Tribuana Kurniaji", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 13, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.23917/jdl.v1i1.11157", "pdfUrl": "https://journals2.ums.ac.id/jdl/article/download/11157/3575", "abstract": "The deep learning approach in education has emerged as a promising pedagogical framework for transforming the learning experience to be more holistic, reflective, and aligned with the needs of the twenty‑first century. This study seeks to conceptually explore how the principles of mindful, meaningful, and joyful learning may be integrated through deep learning–based instructional strategies. The methodology comprises a systematic literature review and a conceptual analysis of pertinent academic publications, research reports, and innovative educational practices. Findings reveal that strategies such as personalized learning, project‑based learning, game‑based learning, and community engagement effectively enhance student engagement, critical thinking skills, and intrinsic motivation. Nonetheless, the implementation of deep learning approaches continues to encounter significant challenges, including educator preparedness, limitations in technological infrastructure, and the misalignment of conventional assessment systems. This article recommends the enactment of progressive policy support, the enhancement of professional capacity among educators, and further empirical research to evaluate the efficacy of deep learning strategies across broader contexts. It is anticipated that these findings will contribute to the advancement of more adaptive, inclusive, and empowering educational policies and practices.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.33140/jibf.04.01.04", "doi": "10.33140/jibf.04.01.04", "title": "Black-Litterman Portfolio Optimization using Machine-Learning, Deep Learning and Reinforcement Learning Algorithms", "publicationYear": 2026, "publicationDate": "2026-05-21", "type": "journal-article", "publisher": "Opast Group LLC", "containerTitle": "Journal of Investment, Banking and Finance", "volume": "04", "issue": "01", "page": "01-11", "issn": "2997-2256", "isbn": null, "authors": "Shigolakov Ivan Vasilevich, Joe Wayne Byers", "authorCount": 2, "firstAuthorAffiliation": "World Quant University, USA", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.33140/jibf.04.01.04", "pdfUrl": null, "abstract": "A portfolio optimization plays a critical role in the financial world. Today the portfolio managers, financial and investment analysts, quantitative researchers from different financial institutions and companies try to find new or better approaches to optimize the investment portfolio in comparison with classical techniques. Nobel prized Harry Markowitz in 1952 introduced his world famous model which is still used by financial scientists in researches as a benchmark or as a background to develop new approaches. The model has some limitations in terms of data normality assumption, historical mean- variance approach instead of potential risks evaluation and others. As a result, some assumptions become irrelevant in real market conditions. Black-Litterman model developed by Fischer Black and Robert Litterman in 1992 attempts to handle some limitations of Markowitz model. This research project will use the Black-Litterman model as a background for further investigation. The view matrix construction will use the Machine Learning and Deep Learning models predictions. MLDL-based Black-Litterman model is expected to demonstrate higher cumulative returns and Sharpe ratios in comparison with classical Markowitz and BL models.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.62945/deeplearning.v1i1.214", "doi": "10.62945/deeplearning.v1i1.214", "title": "The Use of Audio Visual Media in Improving Student Learning Outcomes in Islamic Education Learning at SD Negeri 6 Bandar Baru", "publicationYear": 2025, "publicationDate": "2025-01-31", "type": "journal-article", "publisher": "Mandailing Global Edukasia", "containerTitle": "DEEP LEARNING: Journal of Educational Research", "volume": "1", "issue": "1", "page": "196-208", "issn": "3090-1502", "isbn": null, "authors": "Linda Nelsiani, Fauziah", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.62945/deeplearning.v1i1.214", "pdfUrl": "https://ejournal.mgedukasia.or.id/index.php/deeplearning/article/download/214/208", "abstract": "This Classroom Action Research (CAR) investigates the effectiveness of audio-visual media in improving student learning outcomes in Islamic Education, specifically focusing on the attributes of the prophets, at SD Negeri 6 Bandar Baru. Recognizing the potential of multi-sensory learning experiences to enhance student engagement and comprehension, this study implemented audio-visual media as an instructional tool. The research followed a cyclical PTK model, involving planning, action, observation, and reflection. Data on student learning outcomes was collected through pre-tests and post-tests administered before and after the implementation of audio-visual media, while student engagement was observed and documented during the learning process. The study aimed to determine whether the integration of audio-visual media could lead to a significant improvement in students' understanding and retention of the material on the attributes of the prophets, as well as foster a more conducive and engaging learning environment. The findings of this research demonstrated a positive impact of audio-visual media on student learning outcomes in Islamic Education concerning the attributes of the prophets at SD Negeri 6 Bandar Baru. A comparison of pre-test and post-test scores revealed a statistically significant improvement in students' understanding of the material. Furthermore, observations indicated increased student engagement, participation, and enthusiasm during lessons that incorporated audio-visual aids. The interactive and multi-sensory nature of the media appeared to facilitate better comprehension and retention of complex concepts. These results suggest that the strategic application of audio-visual media can be a valuable pedagogical approach for enhancing learning outcomes in Islamic Education, particularly for abstract topics like the attributes of the prophets, and warrants further exploration and implementation in similar educational settings.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.62945/deeplearning.v1i1.197", "doi": "10.62945/deeplearning.v1i1.197", "title": "Improving Student Learning Achievement through Group Guidance in Natural and Social Sciences Subjects at MI Maraqitta'limat Lengkok Lendang", "publicationYear": 2025, "publicationDate": "2025-01-31", "type": "journal-article", "publisher": "Mandailing Global Edukasia", "containerTitle": "DEEP LEARNING: Journal of Educational Research", "volume": "1", "issue": "1", "page": "13-22", "issn": "3090-1502", "isbn": null, "authors": "Harsini", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.62945/deeplearning.v1i1.197", "pdfUrl": "https://ejournal.mgedukasia.or.id/index.php/deeplearning/article/download/197/191", "abstract": "This study aims to investigate the effectiveness of group counseling in improving student achievement in the subject of Natural and Social Sciences at MI Maraqitta’limat Lengkok Lendang. The research is grounded in the growing need for innovative educational approaches that address not only academic content but also students’ motivation, collaboration skills, and personal development. Utilizing a classroom action research (CAR) method, the study was conducted in two cycles, each consisting of planning, action, observation, and reflection stages. The subjects were fifth-grade students who demonstrated low academic performance and limited participation in classroom activities. Data collection methods included tests, observations, field notes, and student interviews. The results indicate a significant improvement in student learning outcomes after the implementation of group counseling. In Cycle I, only 56% of students reached the minimum competency standard, whereas in Cycle II, this number increased to 87%. Furthermore, qualitative data revealed an increase in students’ motivation, self-confidence, and ability to work cooperatively with peers. The findings suggest that group counseling is an effective strategy to enhance not only academic achievement but also affective and social aspects of learning. Therefore, it is recommended that educators consider incorporating group counseling techniques into their teaching practices, especially in subjects that require critical thinking and interpersonal skills. This research contributes to the broader discourse on holistic education and offers practical implications for teachers, school counselors, and educational policymakers aiming to foster inclusive and supportive learning environments.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.62945/deeplearning.v1i1.210", "doi": "10.62945/deeplearning.v1i1.210", "title": "Teacher Professionalism and Its Relationship with Student Learning Achievement in Fiqh Subject at MAS Nurul Haq Rite", "publicationYear": 2025, "publicationDate": "2025-01-31", "type": "journal-article", "publisher": "Mandailing Global Edukasia", "containerTitle": "DEEP LEARNING: Journal of Educational Research", "volume": "1", "issue": "1", "page": "146-158", "issn": "3090-1502", "isbn": null, "authors": "Abdul Hafid, Nurmalah", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.62945/deeplearning.v1i1.210", "pdfUrl": "https://ejournal.mgedukasia.or.id/index.php/deeplearning/article/download/210/204", "abstract": "This study investigates the relationship between Fiqh teacher professionalism and student learning achievement at MAS Nurul Haq Rite, Ambalawi District, Bima Regency. Teacher professionalism is defined as the expertise, authority, and quality of a Fiqh teacher's work, encompassing their competence in planning, subject matter mastery, teaching implementation, and assessment skills. Student learning achievement is measured by academic outcomes reflected in grades. Employing a mixed-methods approach combining library research and field research, data was collected through questionnaires administered to randomly selected 10th and 11th-grade students, as well as through observation, interviews, and documentation studies. The collected data was analyzed using the product moment formula and the coefficient of determination to assess the correlation and contribution of teacher professionalism to student learning outcomes. The research findings demonstrate a positive and significant relationship between Fiqh teacher professionalism and student learning achievement at the studied institution. Statistical analysis reveals that teacher professionalism accounts for 50% of the variance in student learning achievement in Fiqh. This indicates that the level of a Fiqh teacher's professionalism is a substantial determinant of student academic success in this subject, while the remaining 50% of the variance is influenced by other factors not explored in this study. These results underscore the critical role of teacher professionalism in fostering improved learning outcomes in Islamic jurisprudence.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.21275/sr26221124055", "doi": "10.21275/sr26221124055", "title": "Artificial Intelligence in Cybersecurity: Machine Learning and Deep Learning for Intelligent Threat Detection", "publicationYear": 2026, "publicationDate": "2026-02-26", "type": "journal-article", "publisher": "International Journal of Science and Research", "containerTitle": "International Journal of Science and Research (IJSR)", "volume": null, "issue": null, "page": "1287-1291", "issn": "2319-7064", "isbn": null, "authors": "Rita Dewanjee", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.21275/sr26221124055", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.23887/jpp.v58i3.95456", "doi": "10.23887/jpp.v58i3.95456", "title": "Penerapan Problem Based Learning Terintegrasi Deep Learning untuk Meningkatkan Motivasi Belajar Siswa", "publicationYear": 2025, "publicationDate": "2025-10-25", "type": "journal-article", "publisher": "Universitas Pendidikan Ganesha", "containerTitle": "Jurnal Pendidikan dan Pengajaran", "volume": "58", "issue": "3", "page": "450-458", "issn": "2549-2608, 2301-7821", "isbn": null, "authors": "Rifninda Nur Linasari, Ana Fitrotun Nisa", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-sa/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.23887/jpp.v58i3.95456", "pdfUrl": "https://ejournal.undiksha.ac.id/index.php/JPP/article/download/95456/35933", "abstract": "Penelitian ini bertujuan untuk menganalisis peningkatan motivasi belajar IPAS siswa kelas V di SD Negeri Jetisjogopaten Tahun Ajaran 2024/2025 setelah diterapkannya model pembelajaran Problem Based Learning terintegrasi pendekatan Deep Learning. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK) dengan subjek penelitian adalah siswa kelas V yang berjumlah 20 orang siswa. Data motivasi belajar IPAS siswa dikumpulkan melalui angket. Data yang diperoleh dianalisis menggunakan analisis statistik deskriptif. Berdasarkan hasil analisis data, pada siklus I rerata motivasi belajar IPAS siswa kelas V di SD Negeri Jetisjogopaten setelah mengikuti pembelajaran dengan menerapkan model pembelajaran Problem Based Learning terintegrasi Deep Learning sebesar 77,82 dan berada pada kategori sedang. Persentase ketuntasan klasikalnya adalah 72,46%. Pada siklus II rerata motivasi belajar IPAS siswa kelas V di SD Negeri Jetisjogopaten setelah mengikuti pembelajaran dengan menerapkan model pembelajaran Problem Based Learning meningkat yakni menjadi 83,45 dan berada pada kategori tinggi. Persentase ketuntasan klasikalnya adalah 87,64%. Berdasarkan hasil tersebut dapat disimpulkan bahwa model pembelajaran Problem Based Learning terintegrasi pendekatan Deep Learning secara efektif mampu meningkatkan motivasi belajar IPAS siswa.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.1530/endoabs.92.op-08-01", "doi": "10.1530/endoabs.92.op-08-01", "title": "Evaluation of learning methods similar to deep learning and device using deep learning for the diagnosis of thyroid nodules", "publicationYear": 2023, "publicationDate": "2023-08-24", "type": "journal-article", "publisher": "Bioscientifica", "containerTitle": "Endocrine Abstracts", "volume": null, "issue": null, "page": null, "issn": "1479-6848", "isbn": null, "authors": "Kwak Jin Young, Daham Kim, Kim Youngsook Kim, Eunjung Lee", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1530/endoabs.92.op-08-01", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.21275/mr23717204529", "doi": "10.21275/mr23717204529", "title": "Object Detection with Deep Learning", "publicationYear": 2023, "publicationDate": "2023-07-05", "type": "journal-article", "publisher": "International Journal of Science and Research", "containerTitle": "International Journal of Science and Research (IJSR)", "volume": "12", "issue": "7", "page": "1300-1304", "issn": "2319-7064", "isbn": null, "authors": "Yash Bhadiyadra", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.21275/mr23717204529", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.23917/jdl.v1i1.11077", "doi": "10.23917/jdl.v1i1.11077", "title": "Deep Learning: Implementation and Impact in Islamic Junior High Schools", "publicationYear": 2025, "publicationDate": "2025-06-16", "type": "journal-article", "publisher": "Universitas Muhammadiyah Surakarta", "containerTitle": "Journal of Deep Learning", "volume": null, "issue": null, "page": "25-36", "issn": "3110-7591", "isbn": null, "authors": "Erda Farid Hidayani, Harun Joko Prayitno, Trisakti Handayani", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.23917/jdl.v1i1.11077", "pdfUrl": "https://journals2.ums.ac.id/jdl/article/download/11077/3514", "abstract": "This study aims to describe the implementation of deep learning strategies at the secondary level within an Islamic educational setting, specifically at SMP Islam Ar‑Rahmah. A descriptive qualitative approach was employed to examine in depth the teaching–learning processes integrated with Islamic values and the school’s sociocultural context. Data were gathered through participatory observation, in‑depth interviews, and the documentation of instructional materials. The findings reveal that deep learning was effectively realized through Problem‑Based Learning (PBL) and Project‑Based Learning (PjBL) in both the natural science (IPA) and social science (IPS) curricula. Students actively engaged in contextualized projects—such as the Socio Project Board initiative and water‑filtration experiments—which fostered critical thinking, collaborative teamwork, and data‑driven decision‑making competencies. Moreover, the integration of religious programming and boarding‑school activities contributed to the development of intrapersonal and interpersonal skills that align with the core values of Pancasila students. Nevertheless, challenges persist, particularly with respect to instructional design and the availability of teacher training. Consequently, systemic support from educational institutions and policymakers is necessary to bolster the sustainable and meaningful implementation of deep learning in Islamic schools.", "subject": null, "language": null, "_run_id": "mmXakoeGzeMWIaF4Y", "_dataset_id": "rNqDrGTpgRkP0nsC3"}
{"paperId": "10.1002/9781683673798.ch7", "doi": "10.1002/9781683673798.ch7", "title": "CRISPR‐Cas13: Biology, Mechanism, and Applications of RNA‐Guided, RNA‐Targeting CRISPR Systems", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "99-120", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Omar O. Abudayyeh, Jonathan S. Gootenberg", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 97, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch7", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch7", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.5771/9783828877719-7", "doi": "10.5771/9783828877719-7", "title": "2 CRISPR/Cas9 – Einführung", "publicationYear": 2021, "publicationDate": "2021", "type": "book-chapter", "publisher": "Tectum – ein Verlag in der Nomos Verlagsgesellschaft", "containerTitle": "CRISPR", "volume": null, "issue": null, "page": "7-10", "issn": null, "isbn": null, "authors": "Luisa Becker-Ritterspach", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5771/9783828877719-7", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch11", "doi": "10.1002/9781683673798.ch11", "title": "Genome Editing with CRISPR‐Cas Systems", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "163-193", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Peter Lotfy, Patrick D. Hsu", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 327, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch11", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch11", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch14", "doi": "10.1002/9781683673798.ch14", "title": "<scp>CRISPR</scp> ‐Based Antimicrobials", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "233-248", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Justen Russell, David Bikard", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 119, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch14", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch14", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1007/978-981-16-8504-0_6", "doi": "10.1007/978-981-16-8504-0_6", "title": "CRISPR Guides", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Springer Nature Singapore", "containerTitle": "CRISPR", "volume": null, "issue": null, "page": "227-240", "issn": null, "isbn": "9789811685033, 9789811685040", "authors": "Ziheng Zhang, Ping Wang, Ji-Long Liu", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 25, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-981-16-8504-0_6", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1007/978-981-16-8504-0_1", "doi": "10.1007/978-981-16-8504-0_1", "title": "Development and Vision of CRISPR-Based Technology", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Springer Nature Singapore", "containerTitle": "CRISPR", "volume": null, "issue": null, "page": "1-22", "issn": null, "isbn": "9789811685033, 9789811685040", "authors": "Ziheng Zhang, Ping Wang, Ji-Long Liu", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 158, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-981-16-8504-0_1", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1007/978-981-16-8504-0_2", "doi": "10.1007/978-981-16-8504-0_2", "title": "Gene Editing Through CRISPR-Based Technology", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Springer Nature Singapore", "containerTitle": "CRISPR", "volume": null, "issue": null, "page": "23-92", "issn": null, "isbn": "9789811685033, 9789811685040", "authors": "Ziheng Zhang, Ping Wang, Ji-Long Liu", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 267, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-981-16-8504-0_2", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch3", "doi": "10.1002/9781683673798.ch3", "title": "Molecular Mechanisms of Type<scp>I CRISPR</scp>‐Cas Systems", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "39-52", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "John van der Oost", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 78, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch3", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch3", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch6", "doi": "10.1002/9781683673798.ch6", "title": "Type V CRISPR‐Cas Systems", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "85-97", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Morgan Quinn Beckett, Anita Ramachandran, Scott Bailey", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 59, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch6", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch6", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch8", "doi": "10.1002/9781683673798.ch8", "title": "CRISPR‐Cas, Horizontal Gene Transfer, and the Flexible (Pan) Genome", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "121-130", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Uri Gophna", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 62, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch8", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch8", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch1", "doi": "10.1002/9781683673798.ch1", "title": "CRISPR‐Cas Systems: Core Features and Common Mechanisms", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "1-12", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Rodolphe Barrangou, Luciano A. Marraffini, Erik J. Sontheimer", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 91, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch1", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch1", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch5", "doi": "10.1002/9781683673798.ch5", "title": "Mechanism of Type <scp>III CRISPR</scp> ‐ <scp>Cas</scp> Immunity", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "71-84", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Luciano A. Marraffini", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 76, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch5", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch5", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1007/978-981-16-8504-0_4", "doi": "10.1007/978-981-16-8504-0_4", "title": "Application of CRISPR-Based Technology in Medical Research and Disease Treatment", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Springer Nature Singapore", "containerTitle": "CRISPR", "volume": null, "issue": null, "page": "141-197", "issn": null, "isbn": "9789811685033, 9789811685040", "authors": "Ziheng Zhang, Ping Wang, Ji-Long Liu", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 166, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-981-16-8504-0_4", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch2", "doi": "10.1002/9781683673798.ch2", "title": "Evolutionary Classification of CRISPR‐Cas Systems", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "13-38", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Kira S. Makarova, Yuri I. Wolf, Eugene V. Koonin", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 19, "referenceCount": 139, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch2", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch2", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.5771/9783828877719-163", "doi": "10.5771/9783828877719-163", "title": "5 Instrumente und Handlungsebenen und Ihrer Akteure zur Regulierung von CRISPR/CAS9", "publicationYear": 2021, "publicationDate": "2021", "type": "book-chapter", "publisher": "Tectum – ein Verlag in der Nomos Verlagsgesellschaft", "containerTitle": "CRISPR", "volume": null, "issue": null, "page": "163-174", "issn": null, "isbn": null, "authors": "Luisa Becker-Ritterspach", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.5771/9783828877719-163", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1007/978-981-16-8504-0_3", "doi": "10.1007/978-981-16-8504-0_3", "title": "Extension and Improvement of CRISPR-Based Technology", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Springer Nature Singapore", "containerTitle": "CRISPR", "volume": null, "issue": null, "page": "93-140", "issn": null, "isbn": "9789811685033, 9789811685040", "authors": "Ziheng Zhang, Ping Wang, Ji-Long Liu", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 145, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-981-16-8504-0_3", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch13", "doi": "10.1002/9781683673798.ch13", "title": "<scp>CRISPR</scp>Screens", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "213-232", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Jonathan D. D'Gama, Joseph S. Park, Matthew K. Waldor", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 132, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch13", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch13", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch10", "doi": "10.1002/9781683673798.ch10", "title": "Regulation of CRISPR‐Cas Expression and Function", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "145-162", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Leah M. Smith, Aroa Rey Campa, Peter C. Fineran", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 142, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch10", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch10", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1016/b978-0-443-23865-9.00004-6", "doi": "10.1016/b978-0-443-23865-9.00004-6", "title": "CRISPR applications for various organisms", "publicationYear": 2025, "publicationDate": "2025", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "CRISPR Handbook", "volume": null, "issue": null, "page": "75-99", "issn": null, "isbn": "9780443238659", "authors": "Zhi-Yan Du", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 101, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-443-23865-9.00004-6", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch15", "doi": "10.1002/9781683673798.ch15", "title": "Exploiting <scp>CRISPR</scp> ‐ <scp>Cas</scp> Systems To Provide Phage Resistance in Industrial Bacteria", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "249-266", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Rodolphe Barrangou, Avery Roberts", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 101, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch15", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch15", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch4", "doi": "10.1002/9781683673798.ch4", "title": "Molecular Mechanisms of Type <scp>II CRISPR</scp> ‐ <scp>Cas</scp> Systems", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "53-69", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Tautvydas Karvelis, Virginijus Siksnys", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 162, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch4", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch4", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1016/b978-0-443-23865-9.00022-8", "doi": "10.1016/b978-0-443-23865-9.00022-8", "title": "Tools and resources for CRISPR technology", "publicationYear": 2025, "publicationDate": "2025", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "CRISPR Handbook", "volume": null, "issue": null, "page": "101-111", "issn": null, "isbn": "9780443238659", "authors": "Zhi-Yan Du", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 2, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-443-23865-9.00022-8", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1016/b978-0-443-23865-9.00002-2", "doi": "10.1016/b978-0-443-23865-9.00002-2", "title": "What is CRISPR?", "publicationYear": 2025, "publicationDate": "2025", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "CRISPR Handbook", "volume": null, "issue": null, "page": "1-22", "issn": null, "isbn": "9780443238659", "authors": "Zhi-Yan Du", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 58, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-443-23865-9.00002-2", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1007/978-981-16-8504-0_5", "doi": "10.1007/978-981-16-8504-0_5", "title": "Application of CRISPR-Based Technology in Plant Gene Editing and Agricultural Engineering", "publicationYear": 2022, "publicationDate": "2022", "type": "book-chapter", "publisher": "Springer Nature Singapore", "containerTitle": "CRISPR", "volume": null, "issue": null, "page": "199-225", "issn": null, "isbn": "9789811685033, 9789811685040", "authors": "Ziheng Zhang, Ping Wang, Ji-Long Liu", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 81, "isOpenAccess": true, "licenseUrl": "https://www.springer.com/tdm", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1007/978-981-16-8504-0_5", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch16", "doi": "10.1002/9781683673798.ch16", "title": "Recording Biological Information with <scp>CRISPR</scp> ‐ <scp>Cas</scp> Systems", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "267-279", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Mariia Y. Cherepkova, Tanmay Tanna, Randall J. Platt", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 36, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch16", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch16", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1016/b978-0-443-23865-9.00003-4", "doi": "10.1016/b978-0-443-23865-9.00003-4", "title": "Applications of CRISPR technology", "publicationYear": 2025, "publicationDate": "2025", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "CRISPR Handbook", "volume": null, "issue": null, "page": "23-74", "issn": null, "isbn": "9780443238659", "authors": "Zhi-Yan Du", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 167, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-443-23865-9.00003-4", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1016/b978-0-443-23865-9.00023-x", "doi": "10.1016/b978-0-443-23865-9.00023-x", "title": "Protocols for CRISPR technology", "publicationYear": 2025, "publicationDate": "2025", "type": "book-chapter", "publisher": "Elsevier", "containerTitle": "CRISPR Handbook", "volume": null, "issue": null, "page": "113-142", "issn": null, "isbn": "9780443238659", "authors": "Zhi-Yan Du", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 5, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/b978-0-443-23865-9.00023-x", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1089/crispr.2018.29011.rba", "doi": "10.1089/crispr.2018.29011.rba", "title": "Cultivating CRISPR", "publicationYear": 2018, "publicationDate": "2018-04", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "The CRISPR Journal", "volume": "1", "issue": "2", "page": "99-100", "issn": "2573-1599, 2573-1602", "isbn": null, "authors": "Rodolphe Barrangou", "authorCount": 1, "firstAuthorAffiliation": "Editor-in-Chief, The CRISPR Journal.", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1089/crispr.2018.29011.rba", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1089/crispr.2020.29108.kda", "doi": "10.1089/crispr.2020.29108.kda", "title": "My CRISPR Book", "publicationYear": 2020, "publicationDate": "2020-10-01", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "The CRISPR Journal", "volume": "3", "issue": "5", "page": "322-324", "issn": "2573-1599, 2573-1602", "isbn": null, "authors": "Kevin Davies", "authorCount": 1, "firstAuthorAffiliation": "Executive Editor, The CRISPR Journal, New Rochelle, New York, USA", "isReferencedByCount": 2, "referenceCount": 3, "isOpenAccess": true, "licenseUrl": "https://journals.sagepub.com/page/policies/text-and-data-mining-license", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1089/crispr.2020.29108.kda", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1089/crispr.2020.29108.kda", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1002/9781683673798.ch12", "doi": "10.1002/9781683673798.ch12", "title": "Genetic and Epigenetic Modulation of Gene Expression by CRISPR‐dCas Systems", "publicationYear": 2022, "publicationDate": "2022-08-30", "type": "other", "publisher": "Wiley", "containerTitle": "Crispr", "volume": null, "issue": null, "page": "195-212", "issn": null, "isbn": "9781683670377, 9781683673798", "authors": "Jasprina N. Noordermeer, Crystal Chen, Lei S. Qi", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 130, "isOpenAccess": true, "licenseUrl": "http://doi.wiley.com/10.1002/tdm_license_1.1", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1002/9781683673798.ch12", "pdfUrl": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781683673798.ch12", "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1089/crispr.2019.0015", "doi": "10.1089/crispr.2019.0015", "title": "Too Much Compromise in Today's CRISPR Pipelines", "publicationYear": 2019, "publicationDate": "2019-06-01", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "The CRISPR Journal", "volume": "2", "issue": "3", "page": "143-145", "issn": "2573-1599, 2573-1602", "isbn": null, "authors": "Richard Fox", "authorCount": 1, "firstAuthorAffiliation": "Data Science, Inscripta, Inc., Boulder, Colorado.", "isReferencedByCount": 5, "referenceCount": 11, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1089/crispr.2019.0015", "pdfUrl": "https://journals.sagepub.com/doi/pdf/10.1089/crispr.2019.0015", "abstract": "Abstract CRISPR-based editing is a revolutionary tool for genome engineering and discovery. The pace of innovation in this young field is truly astonishing, and yet significant gaps remain in the set of capabilities offered. In particular, scalable (massively parallel and multiplex) editing is only available for a small variety of edit types, placing fundamental limits on the kinds of studies researchers can perform. Additional advancements are needed to realize the full potential of the technology.", "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
{"paperId": "10.1089/crispr.2019.29055.rdb", "doi": "10.1089/crispr.2019.29055.rdb", "title": "Time To Let CRISPR B.E.?", "publicationYear": 2019, "publicationDate": "2019-04", "type": "journal-article", "publisher": "SAGE Publications", "containerTitle": "The CRISPR Journal", "volume": "2", "issue": "2", "page": "67-67", "issn": "2573-1599, 2573-1602", "isbn": null, "authors": "Rodolphe Barrangou", "authorCount": 1, "firstAuthorAffiliation": "Editor-in-Chief, The CRISPR Journal", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1089/crispr.2019.29055.rdb", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "eVcEjywxamefemGTf", "_dataset_id": "j4xfx4Cc4trEYHJOx"}
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{"paperId": "10.3410/f.1142923.600018", "doi": "10.3410/f.1142923.600018", "title": "Faculty Opinions recommendation of Global survey of genomic imprinting by transcriptome sequencing.", "publicationYear": 2009, "publicationDate": "2009-01-14", "type": "dataset", "publisher": "H1 Connect", "containerTitle": "Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Hunter Fraser", "authorCount": 1, "firstAuthorAffiliation": "Department of Biology, Stanford University, USA", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.3410/f.1142923.600018", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "EMeSYbCKpDFj0OghX", "_dataset_id": "hQgDaQTKwdZaQhS1q"}
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{"paperId": "10.65695/igvfds0034qrtm", "doi": "10.65695/igvfds0034qrtm", "title": "IGVFDS0034QRTM", "publicationYear": 2024, "publicationDate": "2024-06-27", "type": "dataset", "publisher": "Impact of Genomic Variation on Function (IGVF) Data Administration and Coordination Center", "containerTitle": "IGVF Datasets", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Jay Shendure, UW", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.65695/igvfds0034qrtm", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "EMeSYbCKpDFj0OghX", "_dataset_id": "hQgDaQTKwdZaQhS1q"}
{"paperId": "10.65695/igvfds6028vfbk", "doi": "10.65695/igvfds6028vfbk", "title": "IGVFDS6028VFBK", "publicationYear": 2024, "publicationDate": "2024-06-27", "type": "dataset", "publisher": "Impact of Genomic Variation on Function (IGVF) Data Administration and Coordination Center", "containerTitle": "IGVF Datasets", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Jay Shendure, UW", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.65695/igvfds6028vfbk", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "EMeSYbCKpDFj0OghX", "_dataset_id": "hQgDaQTKwdZaQhS1q"}
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{"paperId": "10.65695/igvfds1064lhgi", "doi": "10.65695/igvfds1064lhgi", "title": "IGVFDS1064LHGI", "publicationYear": 2024, "publicationDate": "2024-06-27", "type": "dataset", "publisher": "Impact of Genomic Variation on Function (IGVF) Data Administration and Coordination Center", "containerTitle": "IGVF Datasets", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Jay Shendure, UW", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.65695/igvfds1064lhgi", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "EMeSYbCKpDFj0OghX", "_dataset_id": "hQgDaQTKwdZaQhS1q"}
{"paperId": "10.65695/igvfds4928zasl", "doi": "10.65695/igvfds4928zasl", "title": "IGVFDS4928ZASL", "publicationYear": 2024, "publicationDate": "2024-06-27", "type": "dataset", "publisher": "Impact of Genomic Variation on Function (IGVF) Data Administration and Coordination Center", "containerTitle": "IGVF Datasets", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Jay Shendure, UW", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.65695/igvfds4928zasl", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "EMeSYbCKpDFj0OghX", "_dataset_id": "hQgDaQTKwdZaQhS1q"}
{"paperId": "10.1093/wentk/9780197647127.003.0007", "doi": "10.1093/wentk/9780197647127.003.0007", "title": "Climate Change and You", "publicationYear": 2022, "publicationDate": "2022-01-09", "type": "book-chapter", "publisher": "Oxford University Press", "containerTitle": "Climate Change", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780197647127, 9780197647165", "authors": "Joseph Romm", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/wentk/9780197647127.003.0007", "pdfUrl": null, "abstract": "This chapter will explore some of the more personal questions that climate change raises for individuals and their families. How will climate change impact you and your family in the coming decades? The transition to a low-carbon economy is inevitable this century, and indeed it...", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1093/hesc/9780198807506.003.0005", "doi": "10.1093/hesc/9780198807506.003.0005", "title": "Climate Change and Agriculture", "publicationYear": 2023, "publicationDate": "2023-11-21", "type": "book-chapter", "publisher": "Oxford University Press", "containerTitle": "Climate Change", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780198807506", "authors": "Andrew Sturman, Hervé Quénol", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/hesc/9780198807506.003.0005", "pdfUrl": null, "abstract": "This chapter discusses how climate change affects agriculture, which plays a major role in providing food for a growing global population. Climate has an impact on agriculture through the effects of such variables as solar radiation, temperature, and rainfall. Moreover, extreme events such as heatwaves, frosts, wind storms, floods, and droughts can have catastrophic effects on agriculture. The chapter also looks into the process of achieving optimal climatic conditions for crops and livestock. It provides an overview of the impacts of climate change in line with the development of climate change adaptation strategies dedicated to agriculture, particularly the wine sector.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1332/policypress/9781529203950.003.0005", "doi": "10.1332/policypress/9781529203950.003.0005", "title": "Climate change victims", "publicationYear": 2018, "publicationDate": "2018-10-03", "type": "book-chapter", "publisher": "Policy Press", "containerTitle": "Climate Change Criminology", "volume": null, "issue": null, "page": "79-96", "issn": null, "isbn": "9781529203950, 9781529204001", "authors": "Rob White", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1332/policypress/9781529203950.003.0005", "pdfUrl": null, "abstract": "This chapter discusses the notion of victimhood as this pertains to climate change. Each section deals with a specific victim category — non-human environmental entities, children and young people, and Indigenous communities. Each grouping has its own specific histories, stories, and issues. What perhaps unites the discussion is an underlying emphasis on adopting an ecocentric perspective that incorporates social and ecological justice. From a human perspective, ecocentrism attempts to strike a balance between the need to utilise resources for human survival and the need to develop rules that facilitate the benign use of the ecosphere. Thus, for example, ensuring the preservation of biocentric values becomes integral to maintaining long-term human needs. To do this means minimising the victimisation of both the human and the non-human — in essence, to assert a form of ecological citizenship.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1093/wentk/9780197647127.003.0002", "doi": "10.1093/wentk/9780197647127.003.0002", "title": "Extreme Weather and Climate Change", "publicationYear": 2022, "publicationDate": "2022-01-09", "type": "book-chapter", "publisher": "Oxford University Press", "containerTitle": "Climate Change", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780197647127, 9780197647165", "authors": "Joseph Romm", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 54, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/wentk/9780197647127.003.0002", "pdfUrl": null, "abstract": "Extreme weather is the earliest manifestation of climate change that most people will be exposed to. This chapter will focus on what science tells us about the remarkable spate of once-in-a-century (and rarer) extreme weather events we have observed in the last few years. It...", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1093/hesc/9780198807506.003.0007", "doi": "10.1093/hesc/9780198807506.003.0007", "title": "Environmental Hazards and Climate Change", "publicationYear": 2023, "publicationDate": "2023-11-21", "type": "book-chapter", "publisher": "Oxford University Press", "containerTitle": "Climate Change", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780198807506", "authors": "Andrew Sturman, Hervé Quénol", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/hesc/9780198807506.003.0007", "pdfUrl": null, "abstract": "This chapter provides an overview of the interplay of environmental hazards and climate change. It focuses on the relationship between environmental hazards, natural disasters, and anthropogenic climate change. The nature and causes of the increased occurrence and intensity of environmental hazards provide further understanding for developing effective adaptation strategies. The chapter also considers how communities can respond to the increased frequency and intensity of extreme events across a range of different areas. Moreover, adaptation to the effects of climate change on the occurrence and intensity of environmental hazards requires detailed knowledge of the underlying processes responsible for their occurrence.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1332/policypress/9781529203950.003.0001", "doi": "10.1332/policypress/9781529203950.003.0001", "title": "Climate change and criminology", "publicationYear": 2018, "publicationDate": "2018-10-03", "type": "book-chapter", "publisher": "Policy Press", "containerTitle": "Climate Change Criminology", "volume": null, "issue": null, "page": "1-18", "issn": null, "isbn": "9781529203950, 9781529204001", "authors": "Rob White", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1332/policypress/9781529203950.003.0001", "pdfUrl": null, "abstract": "This introductory chapter provides an overview of the concept of Climate Change Criminology. Climate Change Criminology rests upon the four pillars of crime and harm; global connectedness and ecological justice; causes and consequences; and power and interests. These are separate but inextricably linked domains of analysis, interpretation, and critique. Each area demands novel ways of thinking about the problem, employing methods and approaches that necessarily push the boundaries of contemporary criminological theory and the purview of modern criminal justice institutions. In several important respects, Climate Change Criminology parallels work which focuses on ‘social harm’ as a constitutive concept. What makes a social harm ‘social’ is the fact that it does not stem from natural causes; it is intrinsically caused by humans. Analysis and response to this is central to the project of Climate Change Criminology.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1093/oso/9780198796282.003.0003", "doi": "10.1093/oso/9780198796282.003.0003", "title": "Animals and Climate Change", "publicationYear": 2021, "publicationDate": "2021-04-01", "type": "book-chapter", "publisher": "Oxford University Press", "containerTitle": "Philosophy and Climate Change", "volume": null, "issue": null, "page": "42-66", "issn": null, "isbn": "9780198796282, 9780191918933", "authors": "Jeff Sebo", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 15, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/oso/9780198796282.003.0003", "pdfUrl": null, "abstract": "This chapter argues that animals matter for climate change and that climate change matters for animals. In particular, animal agriculture will have a significant impact on the climate, and climate change will have a significant impact on wild animals. As a result, we morally ought to resist animal agriculture as part of our mitigation efforts and assist wild animals as part of our adaptation efforts. The chapter also evaluates different strategies for accomplishing these aims, and considers connections with debates about well-being, population ethics and duties to future generations, and the nature and limits of moral and political theory.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.2307/j.ctt7rvrw.8", "doi": "10.2307/j.ctt7rvrw.8", "title": "Climate Change and Distributive Justice:", "publicationYear": 2010, "publicationDate": "2010-02-22", "type": "book-chapter", "publisher": "Princeton University Press", "containerTitle": "Climate Change Justice", "volume": null, "issue": null, "page": "73-98", "issn": null, "isbn": "9781400834402", "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.2307/j.ctt7rvrw.8", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1017/cbo9780511546013.011", "doi": "10.1017/cbo9780511546013.011", "title": "Industry", "publicationYear": 2012, "publicationDate": "2012-12-12", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Climate Change 2007", "volume": null, "issue": null, "page": "447-496", "issn": null, "isbn": null, "authors": "Intergovernmental Panel on Climate Change", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9780511546013.011", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1017/cbo9780511546013", "doi": "10.1017/cbo9780511546013", "title": "Climate Change 2007", "publicationYear": 2007, "publicationDate": "2007", "type": "monograph", "publisher": "Cambridge University Press", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780511546013", "authors": "Intergovernmental Panel on Climate Change", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 7591, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9780511546013", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1332/policypress/9781529203950.003.0008", "doi": "10.1332/policypress/9781529203950.003.0008", "title": "Criminological responses to climate change", "publicationYear": 2018, "publicationDate": "2018-10-03", "type": "book-chapter", "publisher": "Policy Press", "containerTitle": "Climate Change Criminology", "volume": null, "issue": null, "page": "139-154", "issn": null, "isbn": "9781529203950, 9781529204001", "authors": "Rob White", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1332/policypress/9781529203950.003.0008", "pdfUrl": null, "abstract": "This concluding chapter summarises the main propositions and areas of concern for Climate Change Criminology. It also emphasises the role of criminologists as public intellectuals and political activists, and the necessity that there be stewards and guardians of the future. This translates into prioritising research, policy, and practice around climate change themes. For criminologists, this means that they need to go beyond parochial viewpoints and those perspectives that frame harm in terms of national or regional interests. Their loyalty has to be to the planet as a whole, rather than being bound by a narrow prescriptive patriotism based on nation. Ultimately, the endeavour of Climate Change Criminology should be to create the conditions for a future that is more forgiving and generous rather than exploitive of humans, environments, and animals.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1017/cbo9780511546013.014", "doi": "10.1017/cbo9780511546013.014", "title": "Waste management", "publicationYear": 2012, "publicationDate": "2012-12-12", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Climate Change 2007", "volume": null, "issue": null, "page": "585-618", "issn": null, "isbn": null, "authors": "Intergovernmental Panel on Climate Change", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9780511546013.014", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1017/cbo9780511546013.004", "doi": "10.1017/cbo9780511546013.004", "title": "Technical Summary", "publicationYear": 2012, "publicationDate": "2012-12-12", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Climate Change 2007", "volume": null, "issue": null, "page": "25-94", "issn": null, "isbn": null, "authors": "Intergovernmental Panel on Climate Change", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 11, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9780511546013.004", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1017/cbo9780511546013.018", "doi": "10.1017/cbo9780511546013.018", "title": "Glossary", "publicationYear": 2012, "publicationDate": "2012-12-12", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Climate Change 2007", "volume": null, "issue": null, "page": "809-822", "issn": null, "isbn": null, "authors": "Intergovernmental Panel on Climate Change", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9780511546013.018", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1017/cbo9780511546013.001", "doi": "10.1017/cbo9780511546013.001", "title": "Foreword", "publicationYear": 2012, "publicationDate": "2012-12-12", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Climate Change 2007", "volume": null, "issue": null, "page": "vii-viii", "issn": null, "isbn": null, "authors": "Intergovernmental Panel on Climate Change", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9780511546013.001", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1017/cbo9780511546013.013", "doi": "10.1017/cbo9780511546013.013", "title": "Forestry", "publicationYear": 2012, "publicationDate": "2012-12-12", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Climate Change 2007", "volume": null, "issue": null, "page": "541-584", "issn": null, "isbn": null, "authors": "Intergovernmental Panel on Climate Change", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 8, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9780511546013.013", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1017/cbo9780511546013.002", "doi": "10.1017/cbo9780511546013.002", "title": "Preface", "publicationYear": 2012, "publicationDate": "2012-12-12", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Climate Change 2007", "volume": null, "issue": null, "page": "ix-x", "issn": null, "isbn": null, "authors": "Intergovernmental Panel on Climate Change", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9780511546013.002", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1017/cbo9780511546013.005", "doi": "10.1017/cbo9780511546013.005", "title": "Introduction", "publicationYear": 2012, "publicationDate": "2012-12-12", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Climate Change 2007", "volume": null, "issue": null, "page": "95-116", "issn": null, "isbn": null, "authors": "Intergovernmental Panel on Climate Change", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9780511546013.005", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1093/oso/9780195078701.003.0005", "doi": "10.1093/oso/9780195078701.003.0005", "title": "Introduction: Apprehending Climate Change", "publicationYear": 1998, "publicationDate": "1998-10-15", "type": "book-chapter", "publisher": "Oxford University Press", "containerTitle": "Historical Perspectives on Climate Change", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780195078701, 9780197560365", "authors": "James R. Fleming", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/oso/9780195078701.003.0005", "pdfUrl": null, "abstract": "Apprehensions have been multiplying rapidly that we are approaching a crisis in our relationship with nature, one that could have potentially catastrophic results for the sustainability of civilization and even the habitability of the planet. Much of the concern is rightfully focused on changes in the atmosphere caused by human activities. Only a century after the discovery of the stratosphere, only five decades after the invention of chlorofluorocarbons (CFCs), and only two decades after atmospheric chemists warned of the destructive nature of chlorine and other compounds, we fear that ozone in the stratosphere is being damaged by human activity. Only a century after the first models of the carbon cycle were developed, only three decades after regular CO2 measurements began at Mauna Loa Observatory, and only two decades after climate modelers first doubled the CO2 in a computerized atmosphere, we fear that the Earth may experience a sudden and possibly catastrophic warming caused by industrial pollution. These and other environmental problems were brought to our attention mainly by scientists and engineers, but the problems belong to us all. Recently, policy-oriented social scientists, public officials, and diplomats have turned their attention to the complex human dimensions of these issues. New interdisciplinary and multidisciplinary collaborations have arisen between scientists and policymakers to examine the extremely challenging issues raised by global change. There has been a rising tide of literature—scholarly works, new journals, textbooks, government documents, treaties, popular accounts—some quite innovative, others derivative and somewhat repetitious. This has resulted in growing public awareness of environmental issues, new understanding of global change science and policy, widespread concerns over environmental risks, and recently formulated plans to intervene in the global environment through various forms of social and behavioral engineering, and possibly geoengineering. Global change is now at the center of an international agenda to understand, predict, protect, and possibly control the global environment. The changing nature of global change—the historical dimension—has not received adequate attention. Most writing addresses current issues in either science or policy; much of it draws on a few authoritative scientific statements such as those by the Intergovernmental Panel on Climate Change (IPCC); almost none of it is informed by historical sensibility.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1017/cbo9780511546013.006", "doi": "10.1017/cbo9780511546013.006", "title": "Framing issues", "publicationYear": 2012, "publicationDate": "2012-12-12", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Climate Change 2007", "volume": null, "issue": null, "page": "117-168", "issn": null, "isbn": null, "authors": "Intergovernmental Panel on Climate Change", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9780511546013.006", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1017/cbo9780511546013.012", "doi": "10.1017/cbo9780511546013.012", "title": "Agriculture", "publicationYear": 2012, "publicationDate": "2012-12-12", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Climate Change 2007", "volume": null, "issue": null, "page": "497-540", "issn": null, "isbn": "9780511546013", "authors": "Intergovernmental Panel on Climate Change", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 10, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9780511546013.012", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1163/9789004322714_cclc_2023-0134-0619", "doi": "10.1163/9789004322714_cclc_2023-0134-0619", "title": "CLIMATE CHANGE ADAPTATION AND CLIMATE JUSTICE", "publicationYear": 2024, "publicationDate": "2024-11-25", "type": "dataset", "publisher": "Walter de Gruyter GmbH", "containerTitle": "Climate Change and Law Collection", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1163/9789004322714_cclc_2023-0134-0619", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.35831/sor.ccr", "doi": "10.35831/sor.ccr", "title": "Spotlight on Climate Change Research", "publicationYear": 2020, "publicationDate": "2020-08-28", "type": "journal", "publisher": "Spotlight on Research", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.35831/sor.ccr", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1093/oso/9780198796282.003.0009", "doi": "10.1093/oso/9780198796282.003.0009", "title": "Climate Change and Cultural Cognition", "publicationYear": 2021, "publicationDate": "2021-04-01", "type": "book-chapter", "publisher": "Oxford University Press", "containerTitle": "Philosophy and Climate Change", "volume": null, "issue": null, "page": "178-198", "issn": null, "isbn": "9780198796282, 9780191918933", "authors": "Daniel Greco", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 8, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/oso/9780198796282.003.0009", "pdfUrl": null, "abstract": "How should we form beliefs concerning global climate change? For most of us, directly evaluating the evidence isn’t feasible; we lack expertise. So, any rational beliefs we form will have to be based in part on deference to those who have it. But in this domain, questions about how to identify experts can be fraught. This chapter discusses a partial answer to the question of how we in fact identify experts: Dan Kahan’s cultural cognition thesis, according to which we treat experts on factual questions of political import only insofar as they share our moral and cultural values. The chapter then poses some normative questions about cultural cognition: is it a species of irrationality that must be overcome if we are to communicate scientific results effectively, or is it instead an inescapable part of rational belief management? Ultimately, it is argued that cultural cognition is substantively unreasonable, though not formally irrational.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1332/policypress/9781529203950.003.0004", "doi": "10.1332/policypress/9781529203950.003.0004", "title": "Climate change catastrophes and social intersections", "publicationYear": 2018, "publicationDate": "2018-10-03", "type": "book-chapter", "publisher": "Policy Press", "containerTitle": "Climate Change Criminology", "volume": null, "issue": null, "page": "59-78", "issn": null, "isbn": "9781529203950, 9781529204001", "authors": "Rob White", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1332/policypress/9781529203950.003.0004", "pdfUrl": null, "abstract": "This chapter examines the consequences of climate change from the point of view of disasters and their consequences for specific interest and population groups. A key focus is the social intersections that become apparent in such events. For example, the climatic and weather events that form the backdrop to present conflicts in places such as Syria are discussed, as are the gendered vulnerabilities evident in disaster situations such as cyclones and tsunami. Social conflicts stemming from climate change are then elaborated as a more general and increasingly likely scenario. In response to real and perceived threats and risk linked to climate change, issues of security are already generating angst among policy-makers and military planners. Indeed, the securitisation of natural resources, to the detriment of others, is emerging as an important climate-related issue, especially in regard to food, water, land, and air quality.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1332/policypress/9781529203950.003.0007", "doi": "10.1332/policypress/9781529203950.003.0007", "title": "Criminal justice responses to climate change", "publicationYear": 2018, "publicationDate": "2018-10-03", "type": "book-chapter", "publisher": "Policy Press", "containerTitle": "Climate Change Criminology", "volume": null, "issue": null, "page": "117-138", "issn": null, "isbn": "9781529203950, 9781529204001", "authors": "Rob White", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1332/policypress/9781529203950.003.0007", "pdfUrl": null, "abstract": "This chapter addresses how criminal justice institutions are responding to climate change. This entails description of court cases intended to bolster the reduction of carbon emissions and the overall role of climate change litigation in the pursuit of climate justice. The chapter argues that an action plan against climate change must include activities and responses that involve the law and legal change, environmental law enforcement activities, courts and adjudication processes, and direct social action. Ultimately, however, this will also require action in and around the exercise of state power as well — since the carbon vandal more often than not acts with direct and indirect state support, through government policy decisions and via laws and courts that are skewed in pro-business directions. The place and role of the criminologist in pursuit of climate justice, therefore, can never be politically neutral.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1093/hesc/9780192895134.003.0002", "doi": "10.1093/hesc/9780192895134.003.0002", "title": "Climate Change and Patterns in Nature", "publicationYear": 2024, "publicationDate": "2024-07-15", "type": "book-chapter", "publisher": "Oxford University Press", "containerTitle": "Climate Change and Nature", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780192895134, 9780198915096", "authors": "Steve Tilling", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/hesc/9780192895134.003.0002", "pdfUrl": null, "abstract": "This chapter focuses on climate change and patterns in nature. It explores how patterns and processes in nature are influenced by climate. Evidence gathered from individuals, species, and communities looks at the global impacts of climate change. This climate change has impacted on over 90 per cent of known ecological processes. However, if we were to assume that climate change is the sole inflence in species development, range expansions in many species are not as large as expected. This means that biological processes are likely to be important influences. The chapter then argues that there is a concern that biological responses may be lagging behind climate impacts and, in some cases, may be leading to a hidden extinction debt.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
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{"paperId": "10.1163/9789004322714_cclc_2019-0160-599", "doi": "10.1163/9789004322714_cclc_2019-0160-599", "title": "CLIMATE CHANGE MATTERS", "publicationYear": 2022, "publicationDate": "2022-12-15", "type": "dataset", "publisher": "Walter de Gruyter GmbH", "containerTitle": "Climate Change and Law Collection", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1163/9789004322714_cclc_2019-0160-599", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1093/hesc/9780192895134.003.0007", "doi": "10.1093/hesc/9780192895134.003.0007", "title": "Biodiversity, Ecosystem Services, and Climate Change", "publicationYear": 2024, "publicationDate": "2024-07-15", "type": "book-chapter", "publisher": "Oxford University Press", "containerTitle": "Climate Change and Nature", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780192895134, 9780198915096", "authors": "Steve Tilling", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/hesc/9780192895134.003.0007", "pdfUrl": null, "abstract": "This chapter covers the interplay between biodiversity, Ecosystem Services (ES), and climate change. It discusses how healthy biodiversity will help people tackle threats from climate change, referring to the significance of traditional nature reserves and protected areas. Moreover, ES and Nature Based Solutions are being used increasingly to highlight ways in which nature helps to make human life both possible and worth living. The chapter explains the provisioning of ecosystem services, particularly agriculture, forestry, and fisheries. It shows that attempts to protect the essential biodiversity needed to maintain and strengthen future ES in the face of climate change will depend on wide and prolonged community involvement.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1163/9789004322714_cclc_2015-0081-003", "doi": "10.1163/9789004322714_cclc_2015-0081-003", "title": "Climate change litigation – non-fulfilment by Ukraine of its climate change obligations", "publicationYear": 2018, "publicationDate": "2018-02-27", "type": "dataset", "publisher": "Walter de Gruyter GmbH", "containerTitle": "Climate Change and Law Collection", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1163/9789004322714_cclc_2015-0081-003", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1163/9789004322714_cclc_2022-0002-0019", "doi": "10.1163/9789004322714_cclc_2022-0002-0019", "title": "Climate Change", "publicationYear": 2025, "publicationDate": "2025-09-30", "type": "dataset", "publisher": "Walter de Gruyter GmbH", "containerTitle": "Climate Change and Law Collection", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1163/9789004322714_cclc_2022-0002-0019", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1017/cbo9780511546013.020", "doi": "10.1017/cbo9780511546013.020", "title": "List of contributors", "publicationYear": 2012, "publicationDate": "2012-12-12", "type": "book-chapter", "publisher": "Cambridge University Press", "containerTitle": "Climate Change 2007", "volume": null, "issue": null, "page": "827-832", "issn": null, "isbn": null, "authors": "Intergovernmental Panel on Climate Change", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1017/cbo9780511546013.020", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
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{"paperId": "10.1163/9789004322714_cclc_2021-0196-623", "doi": "10.1163/9789004322714_cclc_2021-0196-623", "title": "UN Climate Change Conference 2021 - Local climate action", "publicationYear": 2025, "publicationDate": "2025-09-30", "type": "dataset", "publisher": "Walter de Gruyter GmbH", "containerTitle": "Climate Change and Law Collection", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1163/9789004322714_cclc_2021-0196-623", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
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{"paperId": "10.1163/9789004322714_cclc_2019-0172-662", "doi": "10.1163/9789004322714_cclc_2019-0172-662", "title": "Food Safety Climate Change", "publicationYear": 2022, "publicationDate": "2022-12-15", "type": "dataset", "publisher": "Walter de Gruyter GmbH", "containerTitle": "Climate Change and Law Collection", "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1163/9789004322714_cclc_2019-0172-662", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1093/wentk/9780197647127.003.0003", "doi": "10.1093/wentk/9780197647127.003.0003", "title": "Projected Climate Impacts", "publicationYear": 2022, "publicationDate": "2022-01-09", "type": "book-chapter", "publisher": "Oxford University Press", "containerTitle": "Climate Change", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780197647127, 9780197647165", "authors": "Joseph Romm", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/wentk/9780197647127.003.0003", "pdfUrl": null, "abstract": "This chapter will discuss what climate science projects will happen this century. The focus will be on the so-called business-as-usual case, which assumes no significant global action to reduce greenhouse gas emissions trends in the foreseeable future. The primary source will be the latest scientific...", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
{"paperId": "10.1093/wentk/9780197647127.003.0001", "doi": "10.1093/wentk/9780197647127.003.0001", "title": "Climate Science Basics", "publicationYear": 2022, "publicationDate": "2022-01-09", "type": "book-chapter", "publisher": "Oxford University Press", "containerTitle": "Climate Change", "volume": null, "issue": null, "page": null, "issn": null, "isbn": "9780197647127, 9780197647165", "authors": "Joseph Romm", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1093/wentk/9780197647127.003.0001", "pdfUrl": null, "abstract": "This chapter focuses on climate science as it applies to what science can tell us about the changes we have observed to date and what caused them. The goal is to answer the key questions that people ask about the science.", "subject": null, "language": "en", "_run_id": "IwgBcOqfuIWiR87h7", "_dataset_id": "93YNwi847sPQh77TZ"}
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{"paperId": "10.1016/j.postharvbio.2026.114581", "doi": "10.1016/j.postharvbio.2026.114581", "title": "Active low-oxygen modified atmosphere packaging delays quality deterioration and reveals volatile markers associated with shelf-life evolution in fresh-cut melon", "publicationYear": 2026, "publicationDate": "2026-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Postharvest Biology and Technology", "volume": "242", "issue": null, "page": "114581", "issn": "0925-5214", "isbn": null, "authors": "Michela Palumbo, Bernardo Pace, Wadir M.V. Marchesiello, Giuseppina Spadaccino, Donatella Nardiello, Maria Cefola, Maurizio Quinto", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Ministero dell&apos;Istruzione dell&apos;Università e della Ricerca, Ministero dell&apos;Università e della Ricerca, Ministero dell&apos;Università e della Ricerca, Ministero dell’Istruzione, dell’Università e della Ricerca, European Commission, European Commission", "funderIds": "10.13039/501100024370, 10.13039/501100021856, 10.13039/501100021856, 10.13039/501100003407, 10.13039/501100000780, 10.13039/501100000780", "url": "https://doi.org/10.1016/j.postharvbio.2026.114581", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.icarus.2026.117269", "doi": "10.1016/j.icarus.2026.117269", "title": "Latitudinal and seasonal distributions of CH4, HCN, and C2H2 in Titan’s upper atmosphere from 13 years of Cassini/VIMS observations", "publicationYear": 2026, "publicationDate": "2026-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Icarus", "volume": "460", "issue": null, "page": "117269", "issn": "0019-1035", "isbn": null, "authors": "Chiara Castagnoli, Bianca Maria Dinelli, Federico Fabiano, Manuel López-Puertas, Leonardo Ronchini, Maya García-Comas, Bernd Funke", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 65, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "INAF", "funderIds": "10.13039/501100005184", "url": "https://doi.org/10.1016/j.icarus.2026.117269", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.postharvbio.2026.114520", "doi": "10.1016/j.postharvbio.2026.114520", "title": "Postharvest modulation of the avocado fruit cuticular barrier via controlled atmosphere and shelf-life storage", "publicationYear": 2026, "publicationDate": "2026-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Postharvest Biology and Technology", "volume": "242", "issue": null, "page": "114520", "issn": "0925-5214", "isbn": null, "authors": "Yaarit Kutsher, Ekaterina Manasherova, Oleg Feygenberg, Dalia Maurer, Noam Alkan, Hagai Cohen", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 44, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.postharvbio.2026.114520", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.jeurceramsoc.2026.118631", "doi": "10.1016/j.jeurceramsoc.2026.118631", "title": "Navigating phase pathways in toturite (Ca₃Fe₂Sn₂SiO₁₂) ceramics via atmosphere-temperature control: From topotactic to liquid-phase mediated transformations", "publicationYear": 2026, "publicationDate": "2026-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of the European Ceramic Society", "volume": "46", "issue": "16", "page": "118631", "issn": "0955-2219", "isbn": null, "authors": "Xue Wei, Zengmei He, Hong Pan, Weidong Li, Lirui Liu, Fengchun Ye, Longgong Xia", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 37, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Jiangxi Province Department of Science and Technology, Ministry of Electronics and Information Technology", "funderIds": "10.13039/501100010857, 10.13039/501100008628", "url": "https://doi.org/10.1016/j.jeurceramsoc.2026.118631", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.26599/hyd.2023.9380002.vr", "doi": "10.26599/hyd.2023.9380002.vr", "title": "Green water: Recycling water resources within the ecosystem-atmosphere network [version of record]", "publicationYear": 2026, "publicationDate": "2026-12", "type": "journal-article", "publisher": "Tsinghua University Press", "containerTitle": "Hydrosphere", "volume": "1", "issue": "1", "page": "9380002-VR", "issn": "3006-2160, 3006-0001", "isbn": null, "authors": "Di Xie, Yu Zhang, Deyu Zhong, Guangqian Wang, Songdong Shao", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 46, "isOpenAccess": false, "licenseUrl": null, "funderNames": null, "funderIds": null, "url": "https://doi.org/10.26599/hyd.2023.9380002.vr", "pdfUrl": null, "abstract": "Abstract Green water, temporarily stored in the unsaturated zone of the soil or on the top of vegetation, plays an important role in the natural water cycle and water resource management. Unlike surface water flows, green water recycling has no obvious boundary restrictions and is characterized by long-distance transport. Thus, green water from specific basins can support precipitation not only within the basin but also in neighboring basins and even distant areas. However, water scarcity is typically viewed as a local problem for which management measures at the basin scale seem sufficient without fully considering the interdependence of green water among basins. Limited knowledge of green water recycling could make hydrological water assessments inaccurate. Here, we quantify the global green water recycling network, which links green water as a moisture supply to precipitation and thus contributes to local and remote freshwater resources. Our results show that large basins such as the Congo (green water recycling ratio: 56.6%) are comparatively independent, but still rely to some extent on moisture supplied by other basins (contributing 21.4% of precipitation for the Congo), contradicting the conventional view of basin independence in water management. This illustration of basin interdependence highlights the need for global water governance in the context of the severe global water crisis, and this global green water recycling network provides the basis for a comprehensive assessment of water resources and scarcity under global change.", "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.psj.2026.107301", "doi": "10.1016/j.psj.2026.107301", "title": "Research note: Untargeted metabolomics to understand the impact of controlled atmosphere stunning and electrical stunning on metabolite profiles of early postmortem breast fillet", "publicationYear": 2026, "publicationDate": "2026-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Poultry Science", "volume": "105", "issue": "11", "page": "107301", "issn": "0032-5791", "isbn": null, "authors": "Rishav Kumar, Melissa Boersma, Sunoh Che, Zahidul Tushar, Rabin Raut, Dianna V. Bourassa", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Alabama Agricultural Experiment Station, USDA Agricultural Research Service, National Institute of Food and Agriculture, Auburn University, U.S. Department of Agriculture", "funderIds": "10.13039/100008745, 10.13039/100007917, 10.13039/100005825, 10.13039/100007579, 10.13039/100000199", "url": "https://doi.org/10.1016/j.psj.2026.107301", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.optmat.2026.118342", "doi": "10.1016/j.optmat.2026.118342", "title": "Effect of annealing atmosphere on the laser performance of diffusion-doped ZnSe:Cr active elements", "publicationYear": 2026, "publicationDate": "2026-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Optical Materials", "volume": "179", "issue": null, "page": "118342", "issn": "0925-3467", "isbn": null, "authors": "S.V. Kurashkin, D.V. Savin, O.V. Martynova, O.V. Timofeev, A.P. Savikin, E.O. Timofeev", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 22, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Russian Science Foundation", "funderIds": "10.13039/501100006769", "url": "https://doi.org/10.1016/j.optmat.2026.118342", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.compositesa.2026.110040", "doi": "10.1016/j.compositesa.2026.110040", "title": "Atmosphere-dependent ablation behavior and mechanism in nanosecond laser processing of CFRP composites", "publicationYear": 2026, "publicationDate": "2026-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Composites Part A: Applied Science and Manufacturing", "volume": "210", "issue": null, "page": "110040", "issn": "1359-835X", "isbn": null, "authors": "Hong An, Yongfeng Qian, Haolin Guo, Puhong Xu, Hu Huang, Jiwang Yan", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 61, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Fundamental Research Funds for the Central Universities, Jilin Provincial Natural Science Foundation, National Natural Science Foundation of China", "funderIds": "10.13039/501100013804, 10.13039/100007847, 10.13039/501100001809", "url": "https://doi.org/10.1016/j.compositesa.2026.110040", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.cemconcomp.2026.106788", "doi": "10.1016/j.cemconcomp.2026.106788", "title": "Chloride desorption behavior of cement paste containing wet carbonated recycled cement paste fine under CO2 atmosphere", "publicationYear": 2026, "publicationDate": "2026-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Cement and Concrete Composites", "volume": "174", "issue": null, "page": "106788", "issn": "0958-9465", "isbn": null, "authors": "Yuguang Mao, Xiang Hu, Shuaicheng Guo, Wei Chen, Caijun Shi", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.cemconcomp.2026.106788", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.gsf.2026.102394", "doi": "10.1016/j.gsf.2026.102394", "title": "Fe-rich olivine weathering under a CO2 atmosphere: Implications for iron oxidation and phyllosilicate formation on early Mars", "publicationYear": 2026, "publicationDate": "2026-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Geoscience Frontiers", "volume": "17", "issue": "6", "page": "102394", "issn": "1674-9871", "isbn": null, "authors": "Disheng Zhou, Yu-Yan Sara Zhao, Yuhong Yang, Chao Qi, Erwin Dehouck, Junfeng Chen, Huapei Wang, Junxiang Miao, Honglei Lin, Junhu Wang, Yanxue Wu, Shiling Yang, Xiongyao Li, Jianzhong Liu", "authorCount": 14, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 60, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Natural Science Foundation of China", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.1016/j.gsf.2026.102394", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.jes.2026.02.033", "doi": "10.1016/j.jes.2026.02.033", "title": "Comparative analysis of multiple health risks from different air pollution events", "publicationYear": 2026, "publicationDate": "2026-11", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Environmental Sciences", "volume": "169", "issue": null, "page": "164-174", "issn": "1001-0742", "isbn": null, "authors": "Feixue Zheng, Jinwen Li, Chenjie Hua, Tingyu Liu, Jiali Xie, Zemin Feng, Yusheng Zhang, Chao Yan, Men Xia, Qi Yuan, Federico Bianchi, Tuukka Petäjä, Veli-Matti Kerminen, Markku Kulmala, Kaspar R. Daellenbach, Jing Cai, Yongchun Liu", "authorCount": 17, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 114, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Natural Science Foundation of Hebei Province, Research Council of Finland, Atmosphere and Climate Competence Center, Atmosphere and Climate Competence Center, Atmosphere and Climate Competence Center, National Natural Science Foundation of China, Horizon 2020 Framework Programme", "funderIds": "10.13039/501100003787, 10.13039/501100002341, 10.13039/100031138, 10.13039/100031138, 10.13039/100031138, 10.13039/501100001809, 10.13039/100010661", "url": "https://doi.org/10.1016/j.jes.2026.02.033", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.actaastro.2026.05.035", "doi": "10.1016/j.actaastro.2026.05.035", "title": "Space debris detumbling via plume impingement: Off-pointing, atmosphere, and backscatter effects", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Acta Astronautica", "volume": "247", "issue": null, "page": "691-705", "issn": "0094-5765", "isbn": null, "authors": "Akhilesh S. Tiwari, Anthony Moreno, Sachin Nair, Jacob Neal, Thomas C. Underwood, David B. Goldstein, Philip Varghese", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Air Force Research Laboratory Information Directorate, Small Business Innovation Research", "funderIds": "10.13039/100006602, 10.13039/100006370", "url": "https://doi.org/10.1016/j.actaastro.2026.05.035", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.jece.2026.123913", "doi": "10.1016/j.jece.2026.123913", "title": "Degradation of CIP by CoFe-LDH via ROS and direct electron transfer pathway under N2 atmosphere", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Environmental Chemical Engineering", "volume": "14", "issue": "5", "page": "123913", "issn": "2213-3437", "isbn": null, "authors": "Ying Zhao, Kang Zhang, Ke Zhang, Yixuan Luo, Wentao Zou, Ting Li, Yin Xu", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 54, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Hunan Provincial Natural Science Foundation", "funderIds": "10.13039/501100004735", "url": "https://doi.org/10.1016/j.jece.2026.123913", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.icheatmasstransfer.2026.112202", "doi": "10.1016/j.icheatmasstransfer.2026.112202", "title": "Mechanism and characteristics of combustion and explosion of gases released from thermal runaway of lithium iron phosphate batteries in a carbon monoxide-rich atmosphere in underground coal mines", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "International Communications in Heat and Mass Transfer", "volume": "179", "issue": null, "page": "112202", "issn": "0735-1933", "isbn": null, "authors": "Qi Zhang, Wenchao Song, Enhua Shi, Haiyan Chen, Hongda Cao, Kunyu Li, Bowen Liu, Yixiang Fu, Jun Wang, Yuhang Ji, Gang Zhou", "authorCount": 11, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 52, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "China Postdoctoral Science Foundation", "funderIds": "10.13039/501100002858", "url": "https://doi.org/10.1016/j.icheatmasstransfer.2026.112202", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.ascom.2026.101170", "doi": "10.1016/j.ascom.2026.101170", "title": "Quantifying detection bias and recovering habitable zone occurrence rates in the NASA exoplanet archive", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Astronomy and Computing", "volume": "57", "issue": null, "page": "101170", "issn": "2213-1337", "isbn": null, "authors": "Aarav Shah, Saummya Salve, Shreyansh Joshi", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 12, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.ascom.2026.101170", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.icarus.2026.117170", "doi": "10.1016/j.icarus.2026.117170", "title": "Revisiting the CO2 stability problem of the Martian atmosphere with a three-dimensional climate-photochemistry model", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Icarus", "volume": "457", "issue": null, "page": "117170", "issn": "0019-1035", "isbn": null, "authors": "Yangcheng Luo, François Forget, Franck Lefèvre", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Grand Équipement National De Calcul Intensif, European Research Council, CNES, Horizon 2020 Framework Programme, Centre Informatique National de l’Enseignement Supérieur", "funderIds": "10.13039/501100010190, 10.13039/501100000781, 10.13039/501100002830, 10.13039/100010661, 10.13039/501100024807", "url": "https://doi.org/10.1016/j.icarus.2026.117170", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.jece.2026.124351", "doi": "10.1016/j.jece.2026.124351", "title": "Molecular adsorption and infrared-driven photocatalytic performance of nitrogen-defective g-C3N4 regulated by Ti doping and oxygen atmosphere treatment", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Environmental Chemical Engineering", "volume": "14", "issue": "5", "page": "124351", "issn": "2213-3437", "isbn": null, "authors": "Ziqian Zhang, Ziheng Li, Yu Wang, Yixuan Chen, Yitian Wang, Yuyang Guo, Run Liu, Guancheng Wang, Xingyu Gao, Youyu Pang", "authorCount": 10, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 43, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Fundamental Research Funds for the Central Universities, Jilin University", "funderIds": "10.13039/501100012226, 10.13039/501100004032", "url": "https://doi.org/10.1016/j.jece.2026.124351", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.postharvbio.2026.114425", "doi": "10.1016/j.postharvbio.2026.114425", "title": "Microbial kinetics revealed the deterioration mechanism of flavor quality of modified atmosphere packaging Tricholoma matsutake", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Postharvest Biology and Technology", "volume": "240", "issue": null, "page": "114425", "issn": "0925-5214", "isbn": null, "authors": "Ningjing Guo, Ya Dai, Yunkun Ling, Xue Li, Thomas Lettmann, George Owuor, Xiang Li", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 55, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "International Science and Technology Cooperation Programme, Chengdu University, National Key Research and Development Program of China", "funderIds": "10.13039/501100012326, 10.13039/501100013792, 10.13039/501100012166", "url": "https://doi.org/10.1016/j.postharvbio.2026.114425", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.diamond.2026.113971", "doi": "10.1016/j.diamond.2026.113971", "title": "Chemical-free dual-atmosphere pyrolysis of tapioca-derived porous carbon for enhanced super-capacitive performance", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Diamond and Related Materials", "volume": "168", "issue": null, "page": "113971", "issn": "0925-9635", "isbn": null, "authors": "Rika Taslim, Muhammad Abdul Razzaq Zain, Muhammad Ihsan Hamdy, Abrar, Ahmad Fudholi, Apriwandi, Erman Taer", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 75, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Kementerian Pendidikan", "funderIds": "10.13039/501100004565", "url": "https://doi.org/10.1016/j.diamond.2026.113971", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.matchar.2026.116789", "doi": "10.1016/j.matchar.2026.116789", "title": "Chlorination-oxidation behavior and microstructure-corrosion coupling of GH4202 superalloy in flowing HCl-containing atmosphere", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Materials Characterization", "volume": "240", "issue": null, "page": "116789", "issn": "1044-5803", "isbn": null, "authors": "Song Qin, Caizong Pan, Yang Pan, Yongjun Han, Shuai Shi, Yuehai Song, Jin Huang, Shangzhou Zhang, Zhenhua Meng", "authorCount": 9, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.1016/j.matchar.2026.116789", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.triboint.2026.112149", "doi": "10.1016/j.triboint.2026.112149", "title": "Regulation of Ag doping on passivation-graphitization competition at DLC sliding interfaces under methane atmosphere", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Tribology International", "volume": "222", "issue": null, "page": "112149", "issn": "0301-679X", "isbn": null, "authors": "Qing Yang, Zhongrong Geng, Lin Chen, Guangan Zhang", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 48, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Natural Science Foundation of China, National Natural Science Foundation of China", "funderIds": "10.13039/501100001809, 10.13039/501100001809", "url": "https://doi.org/10.1016/j.triboint.2026.112149", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.geoforum.2026.104672", "doi": "10.1016/j.geoforum.2026.104672", "title": "The luminous state: border governance through light, affect, and atmosphere", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Geoforum", "volume": "175", "issue": null, "page": "104672", "issn": "0016-7185", "isbn": null, "authors": "Kai-Yang Huang", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Taiwan University, American Association of Geographers", "funderIds": "10.13039/501100006477, 10.13039/100010262", "url": "https://doi.org/10.1016/j.geoforum.2026.104672", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.pnucene.2026.106544", "doi": "10.1016/j.pnucene.2026.106544", "title": "Experimental and numerical study of the formation and breakdown of density stratification in an air-steam containment atmosphere with internal cooler and steam injection", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Progress in Nuclear Energy", "volume": "200", "issue": null, "page": "106544", "issn": "0149-1970", "isbn": null, "authors": "Jiahui Zhang, Feng Wang, Haozhi Bian, Feng Liu, Li Gao, Nan Zhang, Zhongning Sun", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 40, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "CNNC, Liaoning Province", "funderIds": "10.13039/501100014883, 10.13039/100017439", "url": "https://doi.org/10.1016/j.pnucene.2026.106544", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.fm.2026.105160", "doi": "10.1016/j.fm.2026.105160", "title": "Effects of Latilactobacillus fuchuensis and marination on spoilage and tyramine formation in rainbow trout packaged under modified atmosphere", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Food Microbiology", "volume": "139", "issue": null, "page": "105160", "issn": "0740-0020", "isbn": null, "authors": "Per Johansson, Elina Säde, Luna Adhikari, Johanna Björkroth, Elina Jääskeläinen", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Walter Ehrström Foundation, Finnish Foundation of Veterinary Research, Novo Nordisk A/S", "funderIds": "10.13039/100019806, 10.13039/501100007404, 10.13039/501100004191", "url": "https://doi.org/10.1016/j.fm.2026.105160", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.35870/emt.v10i4.7003", "doi": "10.35870/emt.v10i4.7003", "title": "Pengaruh Store Atmosphere terhadap Kepuasan Konsumen di Mal Plaza Asia Tasikmalaya", "publicationYear": 2026, "publicationDate": "2026-10-01", "type": "journal-article", "publisher": "Lembaga KITA", "containerTitle": "Jurnal EMT KITA", "volume": "10", "issue": "4", "page": "2262-2272", "issn": "2549-6204, 2579-7972", "isbn": null, "authors": "Dwi Ajeng Rahayu, Iis Miati, Teguh Heri Widodo", "authorCount": 3, "firstAuthorAffiliation": "Sekolah Tinggi Ilmu Administrasi YPPT Priatim Tasikmalaya", "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.35870/emt.v10i4.7003", "pdfUrl": "https://journal.lembagakita.com/emt/article/download/7003/4665", "abstract": "Current consumer behavior shows that shopping activities are no longer solely focused on fulfilling needs, but are also related to the experiences consumers gain while being in a particular place. This condition requires shopping center managers to create an atmosphere that supports visitors’ comfort and attractiveness. This study aims to examine the influence of store atmosphere on consumer satisfaction at Mal Plaza Asia Tasikmalaya and to identify the most dominant dimensions. This study employed a quantitative approach through a survey distributed to 100 respondents selected using incidental sampling. Data were collected using a Likert-scale questionnaire and analyzed using simple linear regression analysis. The results showed that store atmosphere had a positive and significant influence on consumer satisfaction, with a contribution of 81.8% to the variation in consumer satisfaction. The external and general interior dimensions contributed more dominantly than the other dimensions in shaping consumer satisfaction. These findings confirm that store atmosphere plays a strong role in increasing consumer satisfaction, so atmosphere and environmental conditions should become major considerations in shopping center management strategies.", "subject": null, "language": null, "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.vacuum.2026.115506", "doi": "10.1016/j.vacuum.2026.115506", "title": "Simultaneously inhibiting oxidation and improving soft magnetic properties of Fe-based metallic glasses by annealing in reducing atmosphere", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Vacuum", "volume": "253", "issue": null, "page": "115506", "issn": "0042-207X", "isbn": null, "authors": "Caiyun Liu, Binbin Liu, Gongtao Liu, Qian Gao, Xianhui Wang, Lei Hu, Yi Qiao, Feng Ye", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 40, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Natural Science Foundation of China", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.1016/j.vacuum.2026.115506", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.atmosenv.2026.122166", "doi": "10.1016/j.atmosenv.2026.122166", "title": "Monitoring urban carbon dioxide emissions from the atmosphere: insights from vertical tower observations in Beijing, China", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Atmospheric Environment", "volume": "382", "issue": null, "page": "122166", "issn": "1352-2310", "isbn": null, "authors": "Kewei Liu, Wudi Cao, Mingming Zhu, Zifa Wang, Fei Hu, Lin Wu, Xueling Cheng", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 60, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "National Natural Science Foundation of China", "funderIds": "10.13039/501100001809", "url": "https://doi.org/10.1016/j.atmosenv.2026.122166", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.carbpol.2026.125670", "doi": "10.1016/j.carbpol.2026.125670", "title": "Carboxymethyl cellulose-based intelligent modified atmosphere film with humidity monitoring and selective gas permeation for strawberry preservation", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Carbohydrate Polymers", "volume": "389", "issue": null, "page": "125670", "issn": "0144-8617", "isbn": null, "authors": "Donghong Xie, Guojing Zhao, Xiaoju Wang, Ya Huang, Liyuan Zhang, Yaohui You, Shunmin Yi, Guohuan Huang", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 52, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Natural Science Foundation of Guangxi Province, National Natural Science Foundation of China", "funderIds": "10.13039/501100004607, 10.13039/501100001809", "url": "https://doi.org/10.1016/j.carbpol.2026.125670", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.vacuum.2026.115549", "doi": "10.1016/j.vacuum.2026.115549", "title": "Controllable phase transition in Sn-doped Ga2O3 film induced by mixed nitrogen-oxygen growth atmosphere", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Vacuum", "volume": "253", "issue": null, "page": "115549", "issn": "0042-207X", "isbn": null, "authors": "Qi Zhang, Chenxin Gao, Yiming Du, Ziang Xu, Chengbo Sun, Chuanyi Wu, Jia Han, Chen Chen, Munisa Nurmamat, Sheng Li, Fei Chen", "authorCount": 11, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 35, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Department of Education of Zhejiang Province, Natural Science Foundation of Zhejiang Province, National Natural Science Foundation of China, National Natural Science Foundation of China, National Natural Science Foundation of China", "funderIds": "10.13039/501100008867, 10.13039/501100004731, 10.13039/501100001809, 10.13039/501100001809, 10.13039/501100001809", "url": "https://doi.org/10.1016/j.vacuum.2026.115549", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.mineng.2026.110493", "doi": "10.1016/j.mineng.2026.110493", "title": "Efficient separation of iron from limonite through mineral phase transformation technology in a CO2-N2 atmosphere", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Minerals Engineering", "volume": "247", "issue": null, "page": "110493", "issn": "0892-6875", "isbn": null, "authors": "Zhijian Zheng, Wentao Zhou, Xuyang Yu, Yanqing Qin, Jinlin Yang, Dingzheng Wang", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 33, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "China Postdoctoral Science Foundation, National Natural Science Foundation of China", "funderIds": "10.13039/501100002858, 10.13039/501100001809", "url": "https://doi.org/10.1016/j.mineng.2026.110493", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.jlumin.2026.122059", "doi": "10.1016/j.jlumin.2026.122059", "title": "Tuning luminescence and afterglow in Gd2O2S:Pr,Ce ceramics by atmosphere annealing", "publicationYear": 2026, "publicationDate": "2026-10", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Journal of Luminescence", "volume": "298", "issue": null, "page": "122059", "issn": "0022-2313", "isbn": null, "authors": "Hua Liu, Benxue Jiang, Xuanzhe Ma, Bin Yu, Shibin Zhou, Weiming Zheng", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 47, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Fundamental Research Funds for the Central Universities", "funderIds": "10.13039/501100012226", "url": "https://doi.org/10.1016/j.jlumin.2026.122059", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "dvJbatqBeGcbPWlz5", "_dataset_id": "idSKnnKxZ6anmxvbx"}
{"paperId": "10.1016/j.vaccine.2019.08.086", "doi": "10.1016/j.vaccine.2019.08.086", "title": "Global oral cholera vaccine use, 2013–2018", "publicationYear": 2020, "publicationDate": "2020-02", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Vaccine", "volume": "38", "issue": null, "page": "A132-A140", "issn": "0264-410X", "isbn": null, "authors": "Lorenzo Pezzoli", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 82, "referenceCount": 87, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Bill and Melinda Gates Foundation", "funderIds": "10.13039/100000865", "url": "https://doi.org/10.1016/j.vaccine.2019.08.086", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "KdRDQ4DObCQJYQ8VC", "_dataset_id": "vf30FwaV9usUzHXXb"}
{"paperId": "10.1016/j.vaccine.2023.02.082", "doi": "10.1016/j.vaccine.2023.02.082", "title": "Editorial from guest editors for Vaccine supplement: Vaccine-derived poliovirus type 2 outbreaks after the cessation of use of oral poliovirus vaccine type 2-2016–2021", "publicationYear": 2023, "publicationDate": "2023-04", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Vaccine", "volume": "41", "issue": null, "page": "A1", "issn": "0264-410X", "isbn": null, "authors": "Chizoba Wonodi, William J. Moss", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 7, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Centers for Disease Control and Prevention, Bill and Melinda Gates Foundation", "funderIds": "10.13039/100000030, 10.13039/100000865", "url": "https://doi.org/10.1016/j.vaccine.2023.02.082", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "KdRDQ4DObCQJYQ8VC", "_dataset_id": "vf30FwaV9usUzHXXb"}
{"paperId": "10.1016/j.vaccine.2025.127890", "doi": "10.1016/j.vaccine.2025.127890", "title": "Adaptive clinical trial designs for rapid vaccine development: Developing country vaccine manufacturers' perspective", "publicationYear": 2025, "publicationDate": "2025-12", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Vaccine", "volume": "68", "issue": null, "page": "127890", "issn": "0264-410X", "isbn": null, "authors": "Manish Mahajan, Laura B. Martin, Kumar Gaurav, Rajinder Kumar Suri", "authorCount": 4, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 18, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Bill and Melinda Gates Foundation, PATH", "funderIds": "10.13039/100000865, 10.13039/100005624", "url": "https://doi.org/10.1016/j.vaccine.2025.127890", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "KdRDQ4DObCQJYQ8VC", "_dataset_id": "vf30FwaV9usUzHXXb"}
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{"paperId": "10.1016/j.vaccine.2019.07.063", "doi": "10.1016/j.vaccine.2019.07.063", "title": "Impact of vaccination delay on deaths averted by pneumococcal conjugate vaccine: Modeled effects in 8 country scenarios", "publicationYear": 2019, "publicationDate": "2019-08", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Vaccine", "volume": "37", "issue": "36", "page": "5242-5249", "issn": "0264-410X", "isbn": null, "authors": "Emily D. Carter, Yvonne Tam, Neff Walker", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 13, "referenceCount": 38, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Bill and Melinda Gates Foundation", "funderIds": "10.13039/100000865", "url": "https://doi.org/10.1016/j.vaccine.2019.07.063", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "KdRDQ4DObCQJYQ8VC", "_dataset_id": "vf30FwaV9usUzHXXb"}
{"paperId": "10.1016/j.vaccine.2019.02.060", "doi": "10.1016/j.vaccine.2019.02.060", "title": "Technical product attributes in development of an oral enteric vaccine for infants", "publicationYear": 2019, "publicationDate": "2019-08", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Vaccine", "volume": "37", "issue": "34", "page": "4800-4804", "issn": "0264-410X", "isbn": null, "authors": "Jessica A. White, Manjari Lal", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Bill and Melinda Gates Foundation, Bill and Melinda Gates Foundation", "funderIds": "10.13039/100000865, 10.13039/100000865", "url": "https://doi.org/10.1016/j.vaccine.2019.02.060", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "KdRDQ4DObCQJYQ8VC", "_dataset_id": "vf30FwaV9usUzHXXb"}
{"paperId": "10.1016/j.vaccine.2016.04.074", "doi": "10.1016/j.vaccine.2016.04.074", "title": "Development of a stable liquid formulation of live attenuated influenza vaccine", "publicationYear": 2016, "publicationDate": "2016-07", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Vaccine", "volume": "34", "issue": "32", "page": "3676-3683", "issn": "0264-410X", "isbn": null, "authors": "Jessica A. White, Marcus Estrada, E. Alexander Flood, Kutub Mahmood, Rajeev Dhere, Dexiang Chen", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 19, "referenceCount": 50, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Bill and Melinda Gates Foundation", "funderIds": "10.13039/100000865", "url": "https://doi.org/10.1016/j.vaccine.2016.04.074", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "KdRDQ4DObCQJYQ8VC", "_dataset_id": "vf30FwaV9usUzHXXb"}
{"paperId": "10.1016/j.vaccine.2026.128370", "doi": "10.1016/j.vaccine.2026.128370", "title": "The AFRO-MoVE network: COVID-19 vaccine research in Africa", "publicationYear": 2026, "publicationDate": "2026-04", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Vaccine", "volume": "77", "issue": null, "page": "128370", "issn": "0264-410X", "isbn": null, "authors": "Celine Gurry, Charles Okot, Anthony Nardone, Kalu Akpaka, Jason M. Mwenda, Benido Impouma", "authorCount": 6, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "World Health Organization, Bill and Melinda Gates Foundation", "funderIds": "10.13039/100004423, 10.13039/100000865", "url": "https://doi.org/10.1016/j.vaccine.2026.128370", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "KdRDQ4DObCQJYQ8VC", "_dataset_id": "vf30FwaV9usUzHXXb"}
{"paperId": "10.1016/j.vaccine.2025.127073", "doi": "10.1016/j.vaccine.2025.127073", "title": "Factors influencing COVID-19 vaccine uptake among pregnant women in Greater Accra Region, Ghana", "publicationYear": 2025, "publicationDate": "2025-05", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Vaccine", "volume": null, "issue": null, "page": "127073", "issn": "0264-410X", "isbn": null, "authors": "Caroline Dinam Badzi, Emefa Modey, Amos Apreku, Chris Guure, Kwasi Torpey, Berhaun Fesshaye, Jessica Schue, Rupali Limaye", "authorCount": 8, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 45, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Gates Foundation", "funderIds": "10.13039/100000865", "url": "https://doi.org/10.1016/j.vaccine.2025.127073", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "KdRDQ4DObCQJYQ8VC", "_dataset_id": "vf30FwaV9usUzHXXb"}
{"paperId": "10.1016/j.vaccine.2021.07.033", "doi": "10.1016/j.vaccine.2021.07.033", "title": "Pneumococcal conjugate vaccine dose-ranging studies in humans: A systematic review", "publicationYear": 2021, "publicationDate": "2021-08", "type": "journal-article", "publisher": "Elsevier BV", "containerTitle": "Vaccine", "volume": "39", "issue": "36", "page": "5095-5105", "issn": "0264-410X", "isbn": null, "authors": "R.K. Lucinde, G. Ong'ayo, C. Houlihan, C. Bottomley, D Goldblatt, J.A.G. Scott, K.E. Gallagher", "authorCount": 7, "firstAuthorAffiliation": null, "isReferencedByCount": 10, "referenceCount": 49, "isOpenAccess": true, "licenseUrl": "https://www.elsevier.com/tdm/userlicense/1.0/", "funderNames": "Bill & Melinda Gates Foundation", "funderIds": "10.13039/100000865", "url": "https://doi.org/10.1016/j.vaccine.2021.07.033", "pdfUrl": null, "abstract": null, "subject": null, "language": "en", "_run_id": "KdRDQ4DObCQJYQ8VC", "_dataset_id": "vf30FwaV9usUzHXXb"}
{"paperId": "10.12688/verixiv.1317.1", "doi": "10.12688/verixiv.1317.1", "title": "Impact analysis of domestic African vaccine supply on low-income global vaccine market", "publicationYear": 2025, "publicationDate": "2025-06-30", "type": "posted-content", "publisher": "F1000 Research Ltd", "containerTitle": null, "volume": null, "issue": null, "page": null, "issn": null, "isbn": null, "authors": "Ruben A. Proano", "authorCount": 1, "firstAuthorAffiliation": "Department of Industrial and Systems Engineering Rochester New York 14623 Rochester Institute of Technology", "isReferencedByCount": 0, "referenceCount": 16, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "funderNames": "Gates Foundation", "funderIds": "10.13039/100000865", "url": "https://doi.org/10.12688/verixiv.1317.1", "pdfUrl": null, "abstract": null, "subject": null, "language": null, "_run_id": "KdRDQ4DObCQJYQ8VC", "_dataset_id": "vf30FwaV9usUzHXXb"}
{"paperId": "10.15407/sofs2025.03.024", "doi": "10.15407/sofs2025.03.024", "title": "«Зелений» імператив відновлення землересурсного потенціалу продовольчої безпеки України", "publicationYear": 2025, "publicationDate": "2025-10-06", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(129)", "page": "24-45", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "В. А. Вергунов, Т. П. Галушкіна", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 21, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2025.03.024", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/22643/20962", "abstract": "Стаття присвячена інноваційній проблемі сучасності — відновленню землересурсного потенціалу України у форматі розбудови державної екологічної стратегії та її новітньої доктрини крізь призму вимог глобального «зеленого» курсу та прагнення України долучитися до європейського альянсу. Актуальність проблеми дослідження зумовлена необхідністю узгодження процесу відновлення природоресурсного капіталу України з пріоритетами світового кліматичного та «зеленого» порядку денного; визначення якісно нової парадигми розбудови державної екологічної політики України на засадах європейської ідеології «зеленого переходу» і низьковуглецевого розвитку та врахування техногенно-мілітарного впливу російської збройної агресії на стан і якість земельних ресурсів; формування інноваційних сценаріїв «зеленої» реконструкції задля забезпечення докорінної модернізації України як майбутнього члена ЄС. Розкрито сутність траєкторії екологічного відновлення землересурсного потенціалу України, порушеного внаслідок техногенно-мілітарного впливу російської збройної агресії, в контексті стратегічних напрямів Плану повоєнної відбудови України за європейським «зеленим» сценарієм. Показано значущість природоресурсної складової, передусім сільськогосподарських земель, як стратегічного чинника забезпечення національної продовольчої безпеки. Представлено візію екологічного відновлення агрокапіталу на засадах європейського «зеленого» сценарію. Вона ґрунтується на принципах екосистемного оцінювання, екологічної репарації та повної компенсації збитків, завданих Україні внаслідок техногенно-мілітарного впливу збройної агресії РФ, а також на кращих інноваційних практиках «зеленої» модернізації з використанням загальновизнаних у міжнародній практиці «зелених» інструментів, зокрема процедури реструктуризації зовнішніх боргів в обмін на природоохоронні активи. Надано пропозиції щодо механізмів втілення сценарію відновлення землересурсного потенціалу як основи забезпечення національної продовольчої безпеки України у повоєнний період шляхом змін у національній екологічній політиці України в бік адаптації до європейських вимог та орієнтації на розбудову державної ідеології сучасного суспільного розвитку та національної безпеки на засадах «зеленого» та «цифрового» переходу.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2023.01.102", "doi": "10.15407/sofs2023.01.102", "title": "Етика як продукт цивілізації та стрижень науки і соціального прогресу: уроки минулого і проблеми сучасності", "publicationYear": 2023, "publicationDate": "2023-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "1(119)", "page": "102-120", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "В.П. Соловйов", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 26, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2023.01.102", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8631/7848", "abstract": "Рівень добробуту у суспільстві залежить від суворості дотримання суб’єктами соціально-економічної діяльності етичних норм поведінки, які встановлюються певною мірою стихійно у процесі соціальної практики. У зв’язку з цим дедалі важливішою стає проблема цілеспрямованого соціально-економічного реформування, що веде і до зміни етичного стрижня соціуму. Метою статті є узагальнення наукових уявлень про етику як набір соціальних інструментів, що впливають на поведінку людини у соціумі. Розуміння цього сприятиме підвищенню ефективності соціально-економічного управління соціумом, зокрема в умовах стихійних лих і соціальних конфліктів. Важливим інструментом такого управління є раціональне залучення наукового потенціалу. Методичною базою дослідження є проблемно-орієнтована методологія зіставлення показників цивілізаційного процесу, які свідчать про сприйняття соціумом етичних принципів у різні історичні періоди. Використані літературні джерела ґрунтуються на соціологічних дослідженнях реалізації принципів забезпечення приросту життєвого блага суспільства. Враховано офіційні джерела, що фіксують сучасне розуміння етичних принципів у різних верствах соціуму. Етична парадигма у кожному еволюційному періоді формується виходячи з припущення, що основні показники цивілізаційного процесу є постійними, а також з упевненості, що прийняті етичні принципи мають забезпечувати приріст життєвого блага суспільства. На особливу увагу заслуговують економічні інструменти коригування етичного простору колективів, зайнятих у системах трансакційного типу. На відміну від країн із відносно стійкою економікою, у країнах із перехідною економікою, до яких належить Україна, можна констатувати наявність низки проблем в етичній інфраструктурі «потрійної спіралі», тобто у сфері політико-адміністративних відносин бізнесу, науки та влади. Етика загалом визначає соціальну організацію суспільства, але спостерігається смислова різниця між авторитарним і гуманістичним розумінням моральності, що знаходить відображення у законодавчо-нормативній базі багатьох країн світу, в тому числі України. Більш змістовне використання науки як інструменту управління розширить можливості влади щодо керування соціально-економічним середовищем в умовах нестабільності та конфліктів.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2020.04.024", "doi": "10.15407/sofs2020.04.024", "title": "Інститут секретних винаходів як фактор забезпечення національної безпеки", "publicationYear": 2020, "publicationDate": "2020-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "4(110)", "page": "24-43", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Г. А. Андрощук", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 17, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2020.04.024", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8841/8034", "abstract": "В роботі надано економіко-правовий аналіз створення та функціонування інституту секретних винаходів у провідних країнах світу та Україні, визначення його ролі в економічному розвитку та забезпеченні національної безпеки. Розглянуто стратегічне значення та важливість секретних винаходів для національної економіки і безпеки, проаналізовано економіко-статистичні показники, організаційно-економічні аспекти засекречування та важливості своєчасного розсекречування винаходів для економічного розвитку країни та світової науки. Наведено мету правової охорони секретних винаходів. Державне регулювання секретних винаходів у зарубіжних країнах з давніми та стабільними патентними системами (США, Великобританія, Німеччина, Франція, Польща) здійснюється в рамках національних патентних законів, що регламентують правову охорону винаходів. Показано, що протягом майже всього XX століття інститут секретних винаходів здійснив величезний внесок у зміцнення національної безпеки таких провідних країн, як США, Великобританія, Німеччина, Франція. У колишньому СРСР інститут секретних винаходів був найважливішим елементом у системі державного режиму секретності, значною мірою забезпечивши можливість досягнення, а потім утримання військово-технічного паритету між СРСР і США. Очевидність необхідності його подальшого збереження в цих країнах не викликає сумніву у фахівців. Аналіз нинішнього стану справ свідчить, що провідні країни світу не лише зберегли свої національні інститути секретних винаходів, а й продовжують активну роботу з їх удосконалення. Звертається увага, що в Законах України «Про охорону прав на винаходи і корисні моделі», «Про державну таємницю» не передбачено норми щодо виплати грошової компенсації власнику секретного винаходу за рішення про їх засекречування, що унеможливлює їх ефективне використання в господарській діяльності. Запропоновано механізм визначення розміру компенсації за засекречування винаходу. В установах, організаціях, на підприємствах України не було проведено інвентаризацію винаходів колишнього СРСР із грифами «Для службового користування» («ДСК») і «таємно» (близько 250 тис.), які належать українським заявникам. Аналізуються втрати від виходу України з Угоди про взаємне забезпечення збереження міждержавних таємниць у галузі правової охорони винаходів, що призвело що невикористання вітчизняними науковцями і конструкторами понад тисячі перспективних технічних рішень при розробленні озброєння і військової техніки. Мінекономрозвитку України спільно з Міністерством оборони України пропонується терміново врегулювати цю проблему. Враховуючи динаміку збільшення патентних заявок у світі в останні роки (відповідно і збільшення кількості винаходів, спрямованих на національну безпеку та оборону), ескалацію міжнародної напруженості, цей економіко-правовий інститут, що безпосередньо займається питаннями національної безпеки, набуватиме все більшого значення.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2024.02.101", "doi": "10.15407/sofs2024.02.101", "title": "Значення Київського акліматизаційного саду академіка М.Ф. Кащенка для розширення асортименту декоративних рослин", "publicationYear": 2024, "publicationDate": "2024-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "2(124)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Н. В. Чувікіна, О. Л. Рубцова", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 7, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2024.02.101", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8595/7816", "abstract": "Стаття присвячена дослідженню колекції декоративних рослин у Акліматизаційному саду академіка М.Ф. Кащенка. Внесок ученого у розширення асортименту лікарських, харчових і технічних рослин здобув широкого визнання, однак його робота з декоративними рослинами відома набагато менше. Розглянуто архівні документи, що зберігаються в Інституті архівознавства Національної бібліотеки України імені В.І. Вернадського та у фондах Музею історії Національного ботанічного саду імені М.М. Гришка НАН України. Виявлено відомості про декоративні рослини, що у різний період зростали в Акліматизаційному саду академіка М.Ф. Кащенка у Києві на «старій» ділянці біля Київського політехнічного інституту, де вчений до 1921 р. викладав зоологію, та на «новій» ділянці по вул. Дорогожицькій (нині вул. Юрія Іллєнка). У дослідженні використано спогади доньки академіка Маргарити Кащенко, хроніки роботи Акліматизаційного саду у 1923—1927 рр., складені однією з найближчих помічниць М.Ф. Кащенка К.С. Калачевською, інвентаризаційні списки рослин Акліматизаційного саду 1944 і 1946 рр. та інші документи. Підкреслено, що високу оцінку асортименту декоративних рослин, які зростали в Акліматизаційному саду на вул. Дорогожицькій на початку 1930-х рр., дав видатний дендролог М.В. Дубовик. Наведено дані про корисні (лікарські, плодові, технічні) рослини різних життєвих форм (дерева, кущі, ліани, трав’янисті рослини), що культивувалися і проходили випробовування в саду. Зазначено, що багато декоративних рослин уперше завезено до Києва саме стараннями М.Ф. Кащенка та його нечисленних помічників; чимала кількість цих рослин нині широко використовується в озелененні, а на деякі з них лише зараз починають звертати увагу садові дизайнери.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2019.04.134", "doi": "10.15407/sofs2019.04.134", "title": "Оборонна тематика в наукових розробках учених НАН України в 70-х рр. ХХ ст. (невідомі сторінки історії): 1971 р.", "publicationYear": 2019, "publicationDate": "2019-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "4(106)", "page": "134-141", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2019.04.134", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8963/8156", "abstract": "Публікуються розсекречені документи Центрального державного архіву громадських об’єднань України про участь АН УРСР в оборонній тематиці. Документи подано мовою оригіналу. Вступ і документи до друку підготовлено:О. Г. ЛуговськийДУ «Інститут досліджень науково-технічного потенціалу та історії науки ім. Г.М. Доброва НАН України»https://orcid.org/0000-0001-7644-5995", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2021.02.117", "doi": "10.15407/sofs2021.02.117", "title": "До історії становлення електровозобудування в Україні: розробка та виробництво промислових локомотивів на Дніпропетровському заводі (1959—1968)", "publicationYear": 2021, "publicationDate": "2021-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "2(112)", "page": "117-136", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "М. Ю. Рубан, В. В. Пономаренко", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 15, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2021.02.117", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8740/7942", "abstract": "У статті досліджено історичні обставини першого десятиліття становлення та розвитку галузі промислового електровозобудування в Україні. При її написанні використано матеріали багатотиражного видання «Електровозобудівник» та накази по Дніпропетровському електровозобудівному заводу (ДЕВЗ) з фондів Державного архіву Дніпропетровської області. Мета статті — відтворити цілісну картину розробки та серійного виробництва промислових електровозів на ДЕВЗ у 1961—1968 рр. Визначено, що протягом 1959—1968-х рр. інженерно-конструкторський колектив ДЕВЗ, маючи потужний науково-виробничий потенціал, на замовлення Міністерства вугільної промисловості СРСР під час переведення під’їзних колій на змінний струм та їх початкової електрифікації з метою імпортозаміщення здійснив розробку й побудував новаторські зразки промислових електровозів серій Д100, Д100М та Д94 для забезпечення потреб радянських гірничодобувних підприємств сучасним високотехнологічним електротранспортом — електровозами для роботи під контактною мережею напругою 10 кВ. З’ясовано, що в 1963 р. на базі перших серійних промислових локомотивів спеціалістами конструкторського бюро ДЕВЗ було розроблено перші на території СРСР маневрові електровози серії Д92 (згодом — ВЛ41), призначені для експлуатації на коліях загального користування, які з часом, унаслідок виявлених конструктивних недоліків, було переведено з інвентарного парку залізниць СРСР для експлуатації на під’їзні колії ряду підприємств та електростанцій. Після виготовлення останніх промислових електровозів серії Д94 у 1968 р. конструктори підприємства зосередились на розробленні тягових агрегатів промислового призначення на замовлення Міністерства чорної металургії СРСР. Подальше дослідження історії ДЕВЗ потребує з’ясування історичних обставин діяльності Спеціального конструкторсько-технологічного бюро ДЕВЗ — від створення промислових електровозів і тягових агрегатів до розробки та переобладнання магістрального тягового рухомого складу, а також спеціалізованої залізничної ремонтної техніки в рамках державного підприємства «Український науково-дослідний проєктно-конструкторський інститут електровозобудування».", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2021.02.064", "doi": "10.15407/sofs2021.02.064", "title": "Молодь Національної академії наук України про реформування Академії", "publicationYear": 2021, "publicationDate": "2021-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "2(112)", "page": "64-76", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "O. С. Попович, С. O. Жабін, В. І. Кліменкова", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2021.02.064", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8732/7934", "abstract": "Статтю присвячено проблемі реформування Національної академії наук України, яка залишається актуальною протягом останніх 30 років. Виходячи з того, що для збереження академічної науки як центральної частини національної інноваційної системи необхідним є поповнення її молоддю та забезпечення спадкоємності в науці, в 2021 році авторами проведено соціологічне опитування молодих вчених. Мета дослідження — виявити та узагальнити думки молодих учених, які працюватимуть в науці в найближчі 20—30 років, щодо питань забезпечення умов плідної праці, підвищення престижності наукової професії та реформування НАН України. Стаття присвячена в основному аналізу відповідей респондентів на питання «Чи поділяєте Ви думку про необхідність реформування НАН України? Вкажіть, яким чином має проходити реформа». Проаналізовано відповіді 350 респондентів із загальної чисельності 2082 дослідників віком до 35 років (що працювали в НАН Україні на момент проведення опитування), які заповнили поміщену у відкритому доступі Google-анкету. Відзначено значне розходження думок респондентів щодо необхідності реформування НАН України: 58 % вважають, що реформування необхідно, 21,1 % відповіли, що потреби в цьому немає, 14 % сумніваються, і їм важко відповісти на це питання. Переважна більшість респондентів вважає, що вкрай недостатнє фінансування є причиною багатьох негараздів і проблем. Хоча більшість респондентів висловилась за реформування НАН України, їх уявлення про те, якою повинна бути ця реформа, виявились досить різними, а часом прямо протилежними — від пропозицій не поспішати з реформами до їх кардинального прискорення, або від застережень щодо неприпустимості передачі інститутів Академії до університетів до вимоги, щоб НАН України перебрала на себе від МОН повноваження з управління науковою сферою, зокрема контролю атестації наукових кадрів вищої кваліфікації. На думку багатьох респондентів, ключовим напрямом реформування має стати дебюрократизація управління наукою. На підставі результатів опитування автори зробили низку висновків: значна частина молодих дослідників НАН України відчуває потребу в реформуванні, хоча їхня частка істотно зменшилась порівняно з 2004 роком; серед респондентів немає єдності поглядів щодо напрямів реформування і втрачається схильність до «реформування заради самого реформування»; стан НАН України викликає занепокоєння у значної частки молодих учених, і тому вони потенційно готові взяти на себе відповідальність за розвиток академічної науки в Україні; окремі пропозиції респондентів можна реалізувати лише за участі та підтримки держави (наприклад, у частині збільшення обсягу фінансування науки); деякі пропозиції вимагають зміни управлінських методів і процедур на рівні Президії НАН України і наукових інститутів, інші — свідчать про необхідність оздоровлення соціально-психологічної атмосфери і дотримання етичних норм у суспільстві, включаючи наукове співтовариство.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2019.04.052", "doi": "10.15407/sofs2019.04.052", "title": "Тематичне ядро публікацій дослідника: наукометричний підхід", "publicationYear": 2019, "publicationDate": "2019-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "4(106)", "page": "52-67", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "С. Г. Бублик", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2019.04.052", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8957/8150", "abstract": "Бібліометричні профілі дослідників формуються з різних за тематичною спрямованістю наукових публікацій. Найбільш впливові із публікацій утворюють тематичне ядро бібліометричного профілю дослідника. Актуальним завданням наукометрії повинен стати не лише моніторинг публікаційної активності певного дослідника чи визначення його h-індексу, а й дослідження тематичного ядра його публікацій. Мета статті — провести наукометричне оцінювання тематичного ядра публікацій дослідника. Для досягнення поставленої мети проведено модифікацію методів лінгвостатистичного аналізу тематичної концентрації слів у тексті та h-індексу для обґрунтування визначення тематичного ядра публікацій. Для формування профілю дослідника (румунського фізика-лінгвіста Іоана-Йовітца Попеску) використовувалися дані бібліометричної бази Google Scholar. Їх використання пояснюється простотою доступу до бібліометричних профілів; можливістю охоплення матеріалів конференцій та неангломовних публікацій, а також проведення ретроспективного аналізу динаміки посилань на публікації та h-індексу. Поява публікацій з різних напрямів досліджень у тематичному ядрі поточного бібліометричного профілю дослідника є не випадковою подією, а наслідком певних закономірних процесів формування тематичних ядер за окремими тематичними напрямами (дисциплінарними, галузевими чи міждисциплінарними). Встановлення переліку всіх основних тематичних публікацій розширює можливості для об’єктивного оцінювання творчого різноманіття дослідницької діяльності ученого. Показано, що тематичне ядро бібліометричного профілю дослідника презентує всі основні тематичні напрями його досліджень. Використання тематичного ядра публікацій як методичного інструменту збільшує можливості бібліометричного та наукометричного аналізу публікаційної діяльності дослідника. Отримані результати свідчать, що більш важливим в оцінюванні ефективності дослідницької діяльності може стати визначення переліку публікацій, які складають тематичне ядро бібліографічного профілю дослідника, ніж його h-індексу.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2026.01.059", "doi": "10.15407/sofs2026.01.059", "title": "Публікаційний профіль біологічних журналів НАН України у 2011—2021 рр.", "publicationYear": 2026, "publicationDate": "2026-03-25", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "1(131)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "В. І. Хорєвін, Т. В. Гончарова, С. І. Примаченко, Т. О. Кухтенко, Т. М. Смирнова", "authorCount": 5, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 27, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2026.01.059", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/28252/22644", "abstract": "Зовнішні та внутрішні наукові комунікації в галузі наук про життя в Україні в 2011—2021 рр. досліджено шляхом аналізу публікацій у 13 біологічних журналах НАН України. Тенденції в цій галузі наук у вказаний період виявлено шляхом наукометричного аналізу публікаційної діяльності біологічних журналів НАН нова Т.М. Публікаційний профіль біологічних журналів НАН України у 2011— sofs2026.01.059 України з використанням спеціально розроблених показників. Установлено, що протягом десяти років загальна щорічна кількість публікацій зменшилась від 777 до 614. Частка статей, авторами або співавторами яких є українські вчені, знизилася протягом аналізованого періоду з 80,0 до 73,8 %; внесок авторів із-за кордону зріс утричі, сягнувши 22 % від загалу; частка статей від авторів із Нових Незалежних Держав зменшилась утричі — з 12,6 % у 2011 р. до 4,2 % у 2021 р. Найактивнішими авторами в 13 біологічних журналах в аналізований період були вчені з інститутів НАН України (60 % статей від загалу); 25 % статей виконані за участю освітян, 10 % — представниками Національної академії медичних наук України та Міністерства охорони здоров’я України. Біологічні дослідження сконцентровані у Києві, на який припадає дві третини статей, чиї автори походять із України, і 12 з 13 проаналізованих журналів. У Харкові, де виходить один із 13 досліджених журналів, працювали автори приблизно 10 % від загалу українських публікацій, внесок авторів з інших регіонів України складав лише кілька відсотків. Учені з інститутів, які є базою для наукового забезпечення аналізованих видань, були авторами 20—60 % щорічної кількості статей у дев’яти виданнях, 90 % статей — в інших двох виданнях, і менше від 20 % статей — у решті двох видань. Бібліографічний аналіз п’яти біологічних журналів виявив тенденцію до збільшення кількості посилань і частки закордонних джерел, яка у чотирьох виданнях у 2021 р. перевищувала 90 %. Водночас зменшився показник самоцитування журналів, особливо в одному виданні, де кількість статей за участю закордонних авторів зросла у кілька разів. Отже, біологічні журнали НАН України протягом 2011—2021 рр. продовжили інтегруватись у світовий науковий простір, про що свідчить зростання кількості статей іноземних авторів, а також статей, підготовлених українськими вченими у співавторстві з іноземними колегами. Одним із суттєвих доказів високого наукового рівня біологічних журналів НАН України є той факт, що 12 із 13 досліджених видань індексовані у бібліографічній базі даних Scopus.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2023.04.003", "doi": "10.15407/sofs2023.04.003", "title": "Феномен безвитратних і наближених до них тем в установах Міністерства освіти і науки України", "publicationYear": 2023, "publicationDate": "2023-04-04", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "4(122)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "І. О. Булкін", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 10, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2023.04.003", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8684/7893", "abstract": "Статтю присвячено аналізу феномену безвитратних і наближених до них науково-дослідних і дослідно-конструкторських робіт (НДДКР), а її актуальність пов’язана з їх аномальним поширенням у наукових організаціях і закладах вищої освіти Міністерства освіти і науки (МОН) України. Викладено результати дослідження, спрямованого на адаптацію розробленого автором методу аналізу фінансування науково-технічної діяльності в освітянському секторі науки на базі інформаційного масиву реєстраційних карток НДДКР Українського інституту науково-технічної експертизи та інформації за форматом Рубрикатора науково-технічної інформації (Рубрикатора НТІ). Методами дослідження є системний та семантичний аналіз, зіставлення, групування та низка прийомів оброблення параметричних рядів. Розглянуто подвійний статус викладацьких кадрів як науково-педагогічних і пов’язані з цим особливості наукової діяльності викладачів у підпорядкованих МОН України закладах вищої освіти (ЗВО) на рівні конкретних робіт. Зроблено висновок про наявність двох видів наукової діяльності в ЗВО: нормативно-супроводжувальної та спеціалізованої. Сформовано та оброблено вибірку безвитратних і наближених до них робіт, які виконувались у 2017— 2020 рр. Визначено, що масштаби виконання таких робіт у МОН України значно вищі ніж в інших відомствах. До того ж, залежно від урахування фінансових джерел, коштом яких здійснюються такі роботи, їхня кількість є зіставною або перевищує кількість усіх інших робіт, що виконувались в установах МОН України. Визначено, що на рівні класу Рубрикатора НТІ найбільша кількість безвитратних і наближених до них робіт мала місце в економічних науках, освіті та педагогіці, машинобудуванні, сільському та лісовому господарстві. Надано характеристику НДДКР за видами робіт і дисциплінарним профілем установ-виконавців. Наведено низку прикладів некоректної кваліфікації робіт у реєстраційних картках НДДКР. Виконано кореляційний аналіз параметрів вибірки безвитратних і наближених до них робіт для всього масиву НДДКР, зареєстрованих виконавцями з МОН України, у результаті якого гіпотеза щодо гомогенності науки в освітянському секторі не отримала статистичного підтвердження.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2022.03.068", "doi": "10.15407/sofs2022.03.068", "title": "Про завершення та основні підсумки комплексного прогнозно-аналітичного дослідження з метою виявлення найбільш актуальних напрямів наукового пошуку", "publicationYear": 2022, "publicationDate": "2022-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(117)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "О. С. Попович", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 5, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2022.03.068", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8725/7927", "abstract": "У статті викладено організаційно-методичні аспекти комплексного прогнозно-аналітичного дослідження з метою формування пропозицій щодо тематики найбільш актуальних напрямів фундаментальних і прикладних досліджень, проведеного за рішенням Президії НАН України в 2021році. Було виділено дев’ять тематичних напрямів, у кожному з яких сформовано групи експертів і проведено їх опитування у два тури за допомогою Google-анкет. У першому турі вони назвали найбільш актуальні, на їхню думку, напрями досліджень у межах відповідного тематичного напряму. Потім їхні пропозиції проаналізувала узагальнююча робоча група і сформулювала на цій основі 10—15 напрямів для подальшого аналізу з точки зору можливостей їх розвитку в Україні. Рекомендовані групою тематичні напрями досліджень включено до анкет другого туру, в процесі якого експерти оцінювали для кожного напряму наявність в Україні необхідних кваліфікованих кадрів, обладнання, сучасних методів досліджень, наукового доробку, визнаного наукового лідера, експериментально-виробничої бази, зв’язків із провідними науковими школами, потенційних інвесторів. Незважаючи на те, що деякі відділення академій і базові інститути, визначені Президією НАН України для відповідних тематичних напрямів, поставились до виконання доручення досить формально, до дослідження вдалося залучити 268 науковців НАН України та галузевих національних академій. У ряді напрямів експертів виявилось надто мало, і керівникам узагальнюючих робочих груп довелося проводити численні додаткові консультації з авторитетними фахівцями, що врешті-решт позначилось на термінах виконання роботи. Утім отримані результати заслуговують на увагу як фіксація переднього фронту сучасної української науки, яким його бачать вітчизняні науковці, а також мають бути враховані у післявоєнному відновленні України та формуванні державної інноваційної політики. В статті вони представлені лише частково.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2021.01.063", "doi": "10.15407/sofs2021.01.063", "title": "Публікаційна активність учених педагогічних університетів України (2010–2020 рр.) через призму баз даних Scopus та Web of Science", "publicationYear": 2021, "publicationDate": "2021-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "1(111)", "page": "63-80", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "К. С. Акбаш, Н. О. Пасічник, Р. Я. Ріжняк", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 17, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2021.01.063", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8704/18809", "abstract": "Мета статті – визначити особливості та динаміку публікаційної активності вчених педагогічних університетів України за показниками наукометричних баз даних Scopus та Web of Science протягом другого десятиріччя ХХІ століття. Авторами обрано генеральну сукупність педагогічних університетів України, профілі яких представлено принаймні в одній з баз даних – Scopus або Web of Science, та з використанням математико-статистичних методів проаналізовано загальну кількість проіндексованих публікацій, загальну кількість цитувань, h-індекс та структуру основних напрямів наукового пошуку вчених з педагогічних університетів станом на кінець вересня 2020 року. Крім того, для кожного педагогічного університету за базою Web of Science проаналізовано вищеназвані характеристики у вигляді часового ряду його публікаційної активності за останні 10 років. В результаті виявлено, що між основними загальними показниками педагогічних університетів у названих наукометричних базах даних існує значущий зв’язок як всередині баз, так і між ними. Аналіз індексування досліджень учених педагогічних університетів обома базами даних продемонстрував різне ставлення менеджменту компаній-постачальників послуг до розширення охоплення публікацій вчених. Аналіз динамічних рядів показників публікаційної активності вчених із педагогічних університетів протягом 2010–2020 років показав, що з 2015 року кількість проіндексованих публікацій та показники індексування посилань за базою даних Web of Science у більшості педагогічних університетів різко зросли через запровадження вимоги щодо наявності індексованих базами праць науковців як обов’язкової ліцензійної умови та початок індексування базою даних Web of Science ряду нових українських наукових видань з гуманітарних, педагогічних та міждисциплінарних проблем. Крім того виявлено, що статті науковців педагогічних університетів, які були опубліковані протягом досліджуваного періоду, по-різному вплинули на формування ядра h-індексу в конкретних університетах.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2022.01.105", "doi": "10.15407/sofs2022.01.105", "title": "Історико-біографічне дослідження життя та творчості українського астронома Миколи Миколайовича Євдокимова (1868—1941)", "publicationYear": 2022, "publicationDate": "2022-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "1(115)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "М. А. Балишев", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 62, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2022.01.105", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8662/7874", "abstract": "Стаття присвячена дослідженню фактів наукової біографії видатного українського астрометриста Миколи Миколайовича Євдокимова. Основні напрями роботи талановитого вченого та організатора науки були присвячені дослідженню зодіакальних і слабких приполярних зір, виведенню їх паралаксів; визначенню прямих піднесень і схилень опорних зір і великих планет Сонячної системи. Попри низку біографічних публікацій, які висвітлюють певні аспекти наукової, організаційної та педагогічної діяльності астронома, встановлено відсутність комплексної праці, присвяченої відтворенню його повної наукової біографії. Тому метою статті є узагальнення результатів комплексного історико-біографічного дослідження життя і творчості астронома професора Миколи Миколайовича Євдокимова. Через вивчення архівних ретроінформаційних ресурсів з’ясовано основні віхи біографії ученого, етапи його науково-дослідницької та організаційної роботи. Досліджено повну бібліографію праць М.М. Євдокимова, який виконував системні спостереження змінних зір, комет, метеорних потоків, місячних і сонячних затемнень; вивчав проходження Меркурія по диску Сонця; здійснював сейсмічні дослідження; проводив системні дослідження астрономічних інструментів; брав участь у роботах з визначення положень зір-реперів для астероїда (433) Ерос. Розглянуто науково-педагогічну діяльність проф. М.М. Євдокимова, який викладав комплекс математичних, астрономічних і геодезичних дисциплін у різних закладах вищої освіти: Харківському державному університеті, Харківському технологічному інституті, Харківському геодезичному інституті, Харківському інженерно-будівельному інституті. Документально підтверджено доробок ученого у період трансформації організаційних структур Харківської астрономічної обсерваторії та кафедри астрономії у 20-х рр. ХХ ст.; участь у розбудові геодезичної науки та створенні Служби часу у Харкові; наведено приклади громадської діяльності астронома у різних спілках астрономів (Німецькому астрономічному товаристві, Всеросійському астрономічному союзі, всесоюзному Бюро довгот, астрометричній комісії Астрономічної ради АН СРСР та ін.), де М.М. Євдокимов представляв українську астрономічну науку.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2019.04.116", "doi": "10.15407/sofs2019.04.116", "title": "Академік АН УРСР К.К. Хрєнов — вчений у галузі електрозварювання та історії науки і техніки (до 125-річчя від дня народження)", "publicationYear": 2019, "publicationDate": "2019-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "4(106)", "page": "116-131", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "О. М. Корнієнко, А. С. Литвинко, О. Г. Луговський", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 35, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2019.04.116", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8961/8154", "abstract": "Відображено основні моменти життя та діяльності Костянтина Костянтиновича Хрєнова, визначного вченого та організатора науки в галузі металургії та зварювального виробництва, а також історії науки й техніки, академіка АН УРСР (1945), члена Президії АН УРСР (1953—1961), голови Відділу АН УРСР (1954—1964), члена-кореспондента АН СРСР (1953), автора понад двохсот наукових праць і двадцяти винаходів, 125 років від дня народження якого виповнилося 25 лютого 2019 р. Проаналізовано науковий доробок К.К. Хрєнова, який розробив низку технологій та засобів електрозварювання, зокрема дугове зварювання та різання металів під водою, застосовне при відновленні мостів і ремонті суден, холодне зварювання тиском, газопресове зварювання, плазмове різання, зварювання чавуну та дефектоскопію зварних з’єднань, джерела електроживлення для дугового й контактного зварювання, керамічні флюси, електродні покриття. Науковець відомий розробкою інноваційних технологій — це холодне, магнітне, мікроконденсаторне зварювання, газове та плазмове різання металів. Особливе значення для науково-технічного прогресу має створення підводного зварювання. Підводним електричним зварюванням під час війни та в післявоєнний період було відремонтовано тисячі кораблів, мостів, портових конструкцій. У 1945 р. Є.О. Патон запросив К.К. Хрєнова в Інститут електрозварювання на посаду свого заступника з науки. У 1945—1948 та 1963—1975 рр. вчений був завідувачем відділу Інституту електрозварювання АН УРСР, 1948—1952 — Інституту будівельної механіки АН УРСР, 1952—1963 — Інституту електротехніки АН УРСР, 1947— 1958 професором Київського політехнічного інституту. К.К. Хрєнов був також одним із засновників системи освіти в галузі зварювання, вихователем інженерних і наукових кадрів, серед його учнів — 50 докторів і кандидатів наук. На основі віднайдених архівних документів показано роль академіка АН УРСР К.К. Хрєнова у становленні та розвитку досліджень з історії науки і техніки в Україні та СРСР, а також у створенні об’єднань професійних істориків науки і техніки, зокрема Українського відділення Радянського національного об’єднання істориків природознавства і техніки, головою якого він став.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2017.03.108", "doi": "10.15407/sofs2017.03.108", "title": "Розвиток комп’ютерного забезпечення інформатизації класичних університетів України (1991—2011)", "publicationYear": 2017, "publicationDate": "2017-09-09", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(97)", "page": "108-120", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Н. О. Пасічник, Р. Я. Ріжняк", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2017.03.108", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8938/8131", "abstract": "На основі економіко-статистичного аналізу визначено головні закономірності комп’ютерного забезпечення інформатизації генеральної сукупності класичних університетів України в економічних умовах 1991—2011 років. Для аналізу використано дані Міністерства освіти та науки України щодо кількості навчальних дисплейних місць у вищих навчальних закладах (ВНЗ) України та забезпеченості комп’ютерними робочими місцями ВНЗ України у розрахунку на 100 студентів денної форми навчання. Сформульовано висновки щодо динаміки середніх показників забезпеченості класичних університетів комп’ютерною технікою у розрахунку на 100 студентів денної форми навчання, щодо середніх показників варіації такої забезпеченості між різними університетами протягом вказаного періоду та показників варіації забезпеченості окремо взятих університетів, щодо наявності кореляційного зв’язку між часовими рядами, які характеризують забезпеченість класичних університетів комп’ютерною технікою.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2020.04.063", "doi": "10.15407/sofs2020.04.063", "title": "Еволюція економічного контексту положень окремих законів України у сфері науки та науково-технічної діяльності", "publicationYear": 2020, "publicationDate": "2020-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "4(110)", "page": "63-75", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "O. П. Сомова", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 24, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2020.04.063", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8844/8037", "abstract": "Однією з важливих проблем законодавчого забезпечення науки в Україні є ефективність методів аналізу змістовності нормативно-правових актів. Тому метою статті є визначення економічного контексту окремих законів України у сфері науки та науково-технічної діяльності за допомогою лінгвостатистичного підходу до аналізу законодавчих текстів шляхом виділення в них ключових економічних термінів. Для реалізації мети дослідження використано розширений алгоритм лінгвостатистичного визначення подвійного тематичного ядра законодавчого тексту, який охоплює переважну кількість економічних термінів, що містяться у законодавчих текстах. Для вирішення окремих завдань дослідження використовувалися наукознавчий, лінгвостатистичний, наукометричний та статистичний методи. Для визначення еволюції економічного контексту окремих законів України у сфері науки обрано базовий закон про науку України (три його редакції: «Про основи державної політики в сфері науки і науково-технічної діяльності» від 13.12.91 р., «Про наукову і науково-технічну діяльність» від 22.12.98 р., «Про наукову і науково-технічну діяльність» від 26.11.15 р.), а також Закон України «Про інноваційну діяльність» від 04.07.2002 р. та його чинна редакція від 05.12.2012 року. Еволюцію економічного контексту базового закону України про науку досліджено на вибірці 17 економічних термінів (програма, розробка, проект, фонд, кошти, пенсія, технологія, техніка, економічний, експертиза, інноваційний, підприємство, продукція, власність, бюджет, фінансування); Закону України «Про інноваційну діяльність» — на вибірці з 13 термінів (інноваційний, проект, кошти, бюджет, фінансово-кредитний, фінансовий, програма, комунальний, продукт, експертиза, продукція, податок, підприємство). В обох випадках частина термінів має не тільки загальноекономічний, а й науковий зміст. Зроблено висновок, що застосування лінгвостатистичних підходів для наукометричного аналізу законодавчих текстів дозволяє виділити основний та неосновний, або пріоритетний та непріоритетний (вторинний), тематичний контекст їх змістовності. Подібний підхід до аналізу законодавчих актів можна здійснювати в автоматичному режимі після написання відповідних програмних алгоритмів, що дозволить зменшити вплив людського чинника при аналітичному розгляді законодавства. Цей метод буде дуже доречним тоді, коли закон знаходиться на етапі законопроекту, між першим і другим читанням: автоматизований лінгвостатистичний підхід дозволить швидко побачити, як змінюється основна тематична спрямованість закону після внесення поправок, і дозволить значно скоротити час ухвалення закону.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2020.02.096", "doi": "10.15407/sofs2020.02.096", "title": "Історико-біографічне дослідження життя та творчості українського астрофізика професора Мстислава Сергійовича Саврона (1902—1943)", "publicationYear": 2020, "publicationDate": "2020-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "2(108)", "page": "96-124", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "М. А. Балишев", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 41, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2020.02.096", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8797/7995", "abstract": "Стаття присвячена дослідженню життя і творчості вітчизняного астронома М.С. Саврона, фахівця у галузі галактичної та позагалактичної астрономії. Висвітлено етапи наукового шляху талановитого вченого, астронома-спостерігача, який вивчав фізичні характеристики Сонця, успішно фотографував малі планети і астероїди головного поясу (Аквітанію, Весту, Іриду, Флору, Цереру), здійснив серію багаторічних спостережень змінних зір. Саврон одним із перших серед вітчизняних астрономів досліджував змінні зорі, зокрема Нові у сузір’ях Геркулеса, Орла та Ящірки, які, за сучасними даними, є проміжними полярами (DQ Herculis, V603 Aquilae). Астроном вивчав потрійну зоряну систему Дельту Лебедя, спостерігав рідкі зорі О-типу, фотографував відомі кулясті скупчення М13 у сузір’ї Геркулеса та М15 у сузір’ї Пегаса, в якому також міститься багато змінних зір; досліджував довгоперіодичну комету Джонсона (1936). В Харківській астрономічній обсерваторії Саврон виконав ґрунтовну науково-дослідницьку роботу, присвячену проблемі поглинання фотографічних променів в атмосфері Землі. У складі делегації харківських астрономів взяв участь у спостереженнях так званого «Великого радянського затемнення» — повного сонячного затемнення 1936 р. Наведено приклади співпраці астронома з провідними ученими Харківської астрономічної обсерваторії проф. Б.П. Герасимовичем, проф. М.П. Барабашовим, Б.Є. Сємейкіним та П.Г. Пархоменко; показано участь Саврона у розбудові інструментальної бази обсерваторії; проаналізовано його наукові публікації. Розглянуто адміністративно-педагогічну діяльність ученого у закладах вищої освіти: в Харківському державному університеті імені О.М. Горького, Харківському державному педагогічному інституті імені Г.С. Сковороди, зокрема на посадах декана географічного та фізико-математичного факультетів, завідувача кафедри астрономії. Документально підтверджено діяльність проф. М.С. Саврона під час Другої світової війни, зокрема висвітлено його участь в організації Ради наук у Харкові та роботу в Науково-технічній управі під час німецької окупації міста у 1941–1943 рр.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2022.02.048", "doi": "10.15407/sofs2022.02.048", "title": "Оцінювання поточного стану та перспектив розвитку «зеленого» будівництва в країнах Європи", "publicationYear": 2022, "publicationDate": "2022-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "2(116)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "К. Ю. Редько, М. В. Кот", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 6, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2022.02.048", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8689/7899", "abstract": "Стаття присвячена дослідженню рівня розвитку будівельного сектору в різних країнах Європи, включаючи Україну, в контексті активізації «зеленого» будівництва. Наголошено, що будівельна галузь відіграє ключову роль у розвитку сучасної економіки, оскільки вона впливає на ефективність функціонування суб’єктів господарювання через забезпечення основними засобами, створення значної кількості робочих місць і споживання багатьох видів продукції з різних пов’язаних галузей. Зазначено, що будівництво є провідною галуззю економіки з досягнення цілей сталого розвитку та циркулярної економіки як його елементу. Методологічна основа дослідження включає загальнонаукові методи: аналіз і синтез, наукову абстракцію, порівняльний метод. Отримані наукові результати ґрунтуються на використанні табличного та графічного методів. Для проведення прогнозу розвитку будівельної галузі обрано метод екстраполяції. Джерельною базою для дослідження є статистичні джерела вітчизняного та зарубіжного походження (статистична служба ЄС, Державна служба статистики України). За результатами дослідження визначено, що провідними країнами у сфері будівництва є країни Азії (насамперед Китай), США та країни ЄС. Виявлено, що пандемія COVID-19 у 2020 році мала значний вплив на розвиток будівельного сектору у всіх країнах Європи. У процесі економічного аналізу конкурентоспроможності країн було використано показники, що визначають розвиток галузі у виробничо-фінансовому, науково-технічному, екологічному аспектах, а також характеризують трудові ресурси у будівництві. За результатами аналізу перше місце за рівнем розвитку будівельної галузі посідає Німеччина, друге — Франція, третє — Нідерланди, четверте — Польща; Україна знаходиться на останньому місці з великим відривом від цих лідерів. Прогноз обсягів будівництва в Україні продемонстрував потенційну можливість до зростання, проте авторами визначено фактори, які можуть загальмувати його темпи. Показано, що перспективними напрямами розвитку будівельного сектору, які прискорюють впровадження принципів циркулярної економіки та сталого розвитку в європейських країнах, включаючи Україну, є інформаційне моделювання будівель (використання BIM-технологій), декарбонізація будівництва, виробництво будівельних матеріалів і підвищення рівня енергоефективності будівель.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2018.01.030", "doi": "10.15407/sofs2018.01.030", "title": "What Has the Ukrainian Legislation Proposed to Management for Research Quality?", "publicationYear": 2018, "publicationDate": "2018-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "1(99)", "page": "30-42", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "S. M. Porev", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 30, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2018.01.030", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8854/8047", "abstract": "This article represents the study of Ukrainian legislative documents in order to define, how they promote scientific quality, performance and excellence. The research management problem is defined as a limitation to use direct research and knowledge management and a reason for implementation of indirect criteria. The study shows that aims, principles and requirements on scientific quality, excellence and performance as motivated proposals mainly absent in Ukrainian legislation and they have no systemic context for realization. It is noted, that an operative use of scientific degrees and academic titles as criteria of scientific quality leads to the weakness of policy, because they mainly represent the social status and qualification. Another weaken position in legislation is an absence of requirements for research assessment of individual scientists in order to stimulate research excellence and competition between them. The main result is that socioeconomic transformations may damage the unity of research policy, legislation and management and change the values of cognitive and creative activities.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2026.02.030", "doi": "10.15407/sofs2026.02.030", "title": "Прикладні аспекти управління комерціалізацією інтелектуальної власності: світові тенденції та українські реалії", "publicationYear": 2026, "publicationDate": "2026-05-25", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "2(132)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "О. І. Жилінська, М. С. Підпала", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 14, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2026.02.030", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/29255/23351", "abstract": "В умовах глобальної цифровізації та технологічної трансформації інтелектуальна власність (ІВ) перетворюється на ключовий стратегічний актив. Здатність його ефективно комерціалізувати визначає конкурентоспроможність як окремих компаній, так і національних інноваційних систем. У статті розкрито прикладні аспекти управління комерціалізацією ІВ в українських компаніях у контексті світових тенденцій розвитку високотехнологічного сектору; перспективні напрями розвитку інноваційної екосистеми України з урахуванням міжнародного досвіду і моделі відкритих інновацій. Методологія дослідження ґрунтується на комплексі загальнонаукових і спеціальних методів: порівняльного аналізу, статистичного аналізу динаміки патентної активності та міжнародних інноваційних індексів, PESTLE-аналізу та SWOT-аналізу, експертного оцінювання зрілості управління ІВ. Джерельну базу становлять аналітичні доповіді міжнародних організацій, дані Національного офісу інтелектуальної власності України та відкриті корпоративні дані досліджуваних компаній. На основі порівняльного аналізу інноваційних моделей провідних країн світу та динаміки позицій України у міжнародних рейтингах у 2020—2024 рр. виявлено системний дисбаланс між наявним науково-технологічним потенціалом країни та рівнем його комерціалізації. Досліджено успішні приклади українських інноваційних компаній — Grammarly, Ajax Systems та Petcube — з точки зору найкращих практик управління ІВ та механізмів її комерціалізації. Розроблено матрицю оцінювання зрілості управління ІВ в інноваційних компаніях України за п’ятьма критеріями (стратегія ІВ — наявність цілісної політики реєстрації та захисту ІВ; комерціалізація ІВ — ефективність механізмів монетизації ІВ; інтеграція ІВ у ДіР — рівень включення ІВ у створення інновацій; елементи відкритих інновацій — використання зовнішніх джерел знань і партнерств; інституціалізація управління ІВ — наявність окремих підрозділів, політик і процедур для керування ІВ). Розраховано індекс зрілості для згаданих вище трьох українських компаній. Здійснено порівняльний аналіз моделей комерціалізації ІВ у цих компаніях в умовах воєнного часу з урахуванням їхньої участі у відкритих інноваціях та географії ринків.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2018.01.061", "doi": "10.15407/sofs2018.01.061", "title": "Зарубіжний досвід роботи з науковою молоддю на прикладі молодіжних академій", "publicationYear": 2018, "publicationDate": "2018-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "1(99)", "page": "61-72", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "О. C. Вашуленко", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 20, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2018.01.061", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8856/8049", "abstract": "Зарубіжний досвід роботи з науковою молоддю проаналізовано на прикладі діяльності молодіжних академій в різних країнах світу. Надано інформацію про історію створення Молодої академії в Німеччині, молодіжних академій в деяких інших країнах, Глобальної молодіжної академії, їх завдання, умови членства, а також заходи щодо заохочення талановитої молоді до наукової діяльності. Згідно з результатами дослідження, молодіжні академії функціонують у більш ніж 40 країнах світу. Досвід України у створенні молодіжних структур у науці показано на прикладі діяльності рад молодих учених. На підставі проведеного аналізу зроблено висновок щодо актуальності створення в Україні організації, подібної до молодіжної академії.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2023.03.142", "doi": "10.15407/sofs2023.03.142", "title": "Становлення та розвиток Дніпровської наукової гідробіологічної школи (30-ті—90-ті роки ХХ ст.). Частина 1", "publicationYear": 2023, "publicationDate": "2023-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(121)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Л. А. Байдак", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 26, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2023.03.142", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8679/7887", "abstract": "У першій частині статті представлено історичну реконструкцію процесів становлення та подальшого розвитку Дніпропетровської наукової гідробіологічної школи, що стала ініціатором вивчення техногенної трансформації прісноводних екосистем, у 30—60-х рр. ХХ ст. Згідно із запропонованою автором хронологічною схемою діяльності школи, на цей період припадають два її етапи: перший (1927—1941 рр.) — здійснення комплексного гідробіологічного вивчення наслідків побудови Дніпрогесу та процесів формування першої великої водойми на Дніпрі — Дніпровського водосховища; другий (1943—1960 рр.) — розвиток і вдосконалення методик гідробіологічного вивчення техногенно-трансформованих прісноводних екосистем. Показано, що базою формування колективу дніпропетровських гідробіологів стала Дніпропетровська державна гідробіологічна станція, у створенні якої провідну роль відіграв проф. Д.О. Свіренко — організатор і перший директор станції, засновник комплексних гідробіологічних досліджень впливу Дніпрогесу на природне водне середовище. Наведено докладну інформацію про експедиційну діяльність дніпропетровських гідробіологів, очолюваних проф. Д.О. Свіренком, яка дала змогу підготувати опис фізико-хімічних і біологічних особливостей Дніпровського водосховища — прісноводної екосистеми колишньої порожистої частини Дніпра, трансформованої у екосистему новоствореної водойми, та стала основою формування нового напряму гідробіології — гідробіології водосховищ. Ці дослідження дніпропетровських гідробіологів стали першими роботами такого плану в Україні та світі, а проф. Д.О. Свіренка у 1934 р. було обрано членом-кореспондентом АН УРСР. У подальшому учні та послідовники проф. Д.О. Свіренка продовжили комплекс започаткованих ним досліджень, значно вдосконаливши методики вивчення техногенно-трансформованих прісноводних екосистем і розширивши географію та проблематику досліджень (формування Каховського, Дніпродзержинського водосховищ, а також водосховищ Криму, Донбасу та Кривбасу).", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2020.03.034", "doi": "10.15407/sofs2020.03.034", "title": "Пріоритети фінансування науково-технічної діяльності в Україні з боку підприємницького сектору. Частина II", "publicationYear": 2020, "publicationDate": "2020-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(109)", "page": "34-63", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "I. О. Булкін", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 3, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2020.03.034", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8816/8013", "abstract": "Актуальність дослідження обумовлена потребою визначення напрямів використання коштів на науково-технічну діяльність, які надходять від підприємницького сектору України, в історичній ретроспекції. Мета статті — ідентифікувати ті сегменти національної науково-технологічної системи, діяльність яких користується підвищеним попитом з боку бізнесу з точки зору його участі у фінансуванні. На основі аналізу даних державної статистики розглянуто ключові характеристики ресурсів підприємницького сектору задля оцінювання ретроспективної динаміки фінансування науково-технічної діяльності підприємницьким сектором та структури розподілу коштів. Здійснено ідентифікацію пріоритетних об’єктів у призмі Класифікації видів науково-технічної діяльності у 2006—2015 роках та у відомчому розрізі — в 2006—2018 роках за сукупністю валових, темпових і питомих показників. Аналіз фінансування науково-технічної діяльності підприємницьким сектором у групі природничих наук продемонстрував, що його пріоритетами протягом аналізованого періоду були роботи в галузі фармацевтичних наук у цілому та профілактичної медицини, зокрема гігієни. В групі технічних наук пріоритетами були роботи в галузі військово-промислового комплексу, авіаційної та ракетно-космічної техніки, роботи військового та подвійного призначення в галузі радіотехніки і телекомунікацій, геодезія і розробка корисних копалин. В групах соціальних і гуманітарних наук пріоритетні об’єкти відсутні. Сформувався тренд до перерозподілу ресурсів підприємницького сектору на дослідження і розробки на користь організацій Державного концерну «Укроборонпром», Державного космічного агентства України та Міністерства економічного розвитку і торгівлі України. Рушієм змін стала мілітаризація науково-технічної сфери як задля задовольняння актуальних оборонних потреб держави, так і для отримання прибутку від міжнародної торгівлі зброєю та супутніми товарами. Фактичний попит українських підприємств на науково-технічну продукцію вітчизняного походження відображається динамікою фінансування бізнес-сектором досліджень і розробок, виконуваних незалежними організаціями. Він має виразно негативний характер.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2020.03.116", "doi": "10.15407/sofs2020.03.116", "title": "До історії реформування залізничного транспорту України: розвиток ремонтної бази вагонного господарства Донецької залізниці (1925–1941)", "publicationYear": 2020, "publicationDate": "2020-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(109)", "page": "116-130", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "М. Ю. Рубан", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 42, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2020.03.116", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8827/8021", "abstract": "Розглянуто історичні події довкола реорганізації виробничої діяльності Луганських залізничних майстерень та її вплив на розвиток ремонтної бази вагонного господарства Донецької залізниці. Джерельну базу дослідження склали матеріали багатотиражних періодичних видань лінійних підприємств залізниць Україні, протоколи засідань Політбюро ЦК ВКП(б) та постанови Ради народних комісарів СРСР початку 1930-х рр. з питань реорганізації транспортної галузі. Мета статті — відтворити цілісну картину обставин реорганізації виробничої діяльності Луганського вагоноремонтного заводу та простежити її вплив на розвиток ремонтної бази Донецької залізниці. Проаналізовано хід реконструкції Луганського механічного заводу вугільного машинобудування та будівництва Луганського трубо-ливарного заводу Народного комісаріату шляхів сполучення (НКШС). Доведено, що через непослідовність заходів щодо реконструкції підприємства та невирішеність питань його матеріально-технічного забезпечення була зірвана початкова програма виробництва гірничого устаткування. Визначено, що з огляду на інтенсивний характер експлуатації залізничного транспорту на Донбасі виникла потреба не тільки у виготовленні паровозних вузлів, а й у локалізації капітального ремонту рухомого складу на місці, в зв’язку з чим постало питання щодо повернення колишніх Луганських залізничних майстерень до складу НКШС. Зрештою, радянським партійним керівництвом було прийнято рішення щодо проведення реформи вагонного господарства, в рамках якої споруджено низку лінійних вагоноремонтних пунктів, зокрема на історичних станціях Донецької залізниці Луганськ, Дебальцеве та Попасна, а також заплановано будівництво сучасного профільного вагоноремонтного заводу на станції Попасна. Розглянуто зміст реформи підприємств вагонного господарства Донецької залізниці та обставини формування матеріально-технічної бази Попаснянського вагоноремонтного заводу.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2017.04.084", "doi": "10.15407/sofs2017.04.084", "title": "Академічно-університетський дуалізм світового дослідницького простору", "publicationYear": 2017, "publicationDate": "2017-11-11", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "4(98)", "page": "84-97", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "В. І. Луговий, О. М. Слюсаренко, Ж. В. Таланова", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 34, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2017.04.084", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8947/8140", "abstract": "Проаналізовано організаційні, фінансові, кадрові характеристики сучасного світового дослідницького простору. У світі 8 країн найбільше інвестують фінансових і людських ресурсів у дослідження і розробки (ДіР) — США, Китай, Японія, Німеччина, Корея, Франція, Велика Британія і Росія. США посідають проміжне місце за співвідношенням бізнесової та урядової ролі у видатках на ДіР, а також часткою університетського сектору як виконавця ДіР (13 %). Вага університетського сектору у виконанні ДіР зазвичай не перевищує чверті сукупних витрат на них і є найбільшою для західноєвропейських та найменшою для східноазійських університетів. У США, Китаї, Німеччині, Франції, інших європейських країнах існують різноманітні позауніверситетські академічні форми здійснення ДіР. Тотальне поглинання університетами наукових установ неможливе через відмінності їхніх місій. В Україні національний дослідницький простір у зв’язку з недофінансуванням перебуває у кризовому стані, його основною інституційною опорою залишаються академії наук. Для підвищення науково-інноваційної спроможності вітчизняних університетів необхідне подолання їх подрібненості, збільшення частки бюджетів на ДіР, посилення дуальної «викладацько-дослідницької» функції науково-педагогічних працівників.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2017.01.022", "doi": "10.15407/sofs2017.01.022", "title": "До розгляду формальних теоретичних передумов функціонування системи управління науково-технологічною сферою", "publicationYear": 2017, "publicationDate": "2017-04-04", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "1(95)", "page": "22-37", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "O. A. Meх", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 73, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2017.01.022", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8892/8084", "abstract": "У статті представлено результати аналізу процесу становлення системних теорій на предмет створення і функціонування на сучасному етапі формальної теорії управління науково-технологічною сферою. Показано зв’язки між теоретичними розробками в галузі управління наукою та уявленнями про системну природу самих наукових напрямів, а також історичні складності ефективного використання таких розробок у розбудові системи управління вітчизняною науково-технологічною сферою. На основі представлених висновків про відсутність формальної теорії управління науково-технологічною сферою окреслено напрями подальших досліджень.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2019.02.158", "doi": "10.15407/sofs2019.02.158", "title": "Оборонна тематика в наукових розробках учених НАН України в 70-х рр. ХХ ст. (невідома сторінка історії)", "publicationYear": 2019, "publicationDate": "2019-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "2(104)", "page": "158-160", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2019.02.158", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8840/8033", "abstract": "Внесок українських учених у виконання науково-дослідницьких і проектно-конструкторських робіт з оборонної тематики й досі залишається «білою» плямою в історії НАН України. Адже наукові розробки в цьому напрямі як окремий об’єкт дослідження ніким і ніколи не вивчалися. Це стає зрозумілим і тому, що всі секретні документи з оборонної тематики в АН УРСР через певний час знищувались, а документи в інститутах засекречувались. Суттєвим джерелом інформації в Центральному державному архіві громадських об’єднань України (ЦДАГО України) є фонд ЦК Компартії України, його таємна частина (ф. 1), де збереглися окремі матеріали Президії та установ НАН України, Держплану УРСР про виконання планових завдань із оборонної тематики. Пропонований документ про підсумки роботи інститутів АН УРСР з оборонної тематики за 1972 рік, підготовлений зав. відділом оборонної промисловості ЦК Компартії України Я. Руденко, подається мовою оригіналу. Вступ і документи до друку підготовлено:О. Г. ЛуговськийДУ «Інститут досліджень науково-технічного потенціалу та історії науки ім. Г.М. Доброва НАН України»https://orcid.org/0000-0001-7644-5995", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2019.03.089", "doi": "10.15407/sofs2019.03.089", "title": "Прорив у світову науку: досвід Г.М.Доброва", "publicationYear": 2019, "publicationDate": "2019-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(105)", "page": "89-93", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Ю. О. Клочко", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2019.03.089", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8925/8117", "abstract": "Надано короткі біографічні відомості про засновника українського наукознавства Г.М. Доброва і поставлено запитання: «Як хлопець із провінції за умов ізоляції країни здійснив прорив у новій галузі гуманітарних знань?» Відповідь на нього надано шляхом аналізу трьох напрямів «прориву» Доброва у глобальний науковий простір у галузі наукознавства: закордонні публікації, особисте входження в міжнародну спільноту, активна діяльність на світовому рівні.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2019.03.134", "doi": "10.15407/sofs2019.03.134", "title": "Оборонна тематика 70-х рр. ХХ ст. в наукових розробках учених НАН України", "publicationYear": 2019, "publicationDate": "2019-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(105)", "page": "134-142", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": null, "authorCount": 0, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2019.03.134", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8935/8127", "abstract": "Публікуються розсекречені документи Центрального державного архіву громадських об’єднань України про участь АН УРСР в оборонній тематиці. Документи подано мовою оригіналу. Вступ і документи до друку підготовлено:О. Г. ЛуговськийДУ «Інститут досліджень науково-технічного потенціалу та історії науки ім. Г.М. Доброва НАН України»https://orcid.org/0000-0001-7644-5995", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2022.04.106", "doi": "10.15407/sofs2022.04.106", "title": "З історії створення надійних деталей бойових гусеничних машин методом електрошлакового переплавлення в Інституті електрозварювання ім. Є.О. Патона АН УРСР (початок 70-х рр. ХХ ст.)", "publicationYear": 2022, "publicationDate": "2022-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "4(118)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "О. С. Войтюк", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 3, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2022.04.106", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8749/7949", "abstract": "У статті висвітлено визначні історичні факти та наукові дані, що розкривають участь учених Інституту електрозварювання ім. Є.О. Патона АН УРСР у розробленні та застосуванні методу електрошлакового переплавлення для виробництва деталей бойових гусеничних машин на початку 70-х рр. ХХ ст., що відображає їхній внесок у розвиток галузі спеціальної електрометалургії та технології металів. Основними джерелами для дослідження стали розсекречені архівні документи з оборонної тематики СРСР Центрального державного архіву громадських об’єднань України, які вперше введено до наукового обігу. Застосовано загальнонаукові та спеціально-історичні методи (ретроспективний, проблемно-хронологічний, порівняльно-історичний, аналіз, синтез і класифікація). Розкрито основні чинники, що впливають на якість електрошлакового металу, зокрема кількість і склад флюсу, електричний режим і технологія виплавлення вихідної заготовки. Розглянуто дослідження вихідного металу електродугового плавлення, який піддавався електрошлаковому переплавленню під різними марками флюсів, а також із розкисленням та модифікуванням металу у процесі електрошлакового переплавлення мікродомішками рідкоземельних металів. Представлено методи оцінювання неметалевих включень у сталі. Показано, що дослідження якості сталі проводилися науковцями Інституту електрозварювання ім. Є.О. Патона АН УРСР спільно з ученими Фізико-механічного інституту АН УРСР і Запорізького машинобудівного інституту. Висвітлено зміст науково-технічних розробок і напрями досліджень із підвищення довговічності штампованих траків фахівцями цих наукових установ. Використання архівних документів дало змогу ґрунтовніше реконструювати історію розвитку наукових досліджень з розроблення деталей бойових гусеничних машин методом електрошлакового переплавлення.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2021.04.138", "doi": "10.15407/sofs2021.04.138", "title": "Науково-технічні розробки українських конструкторів у підготовці першого польоту людини у космос", "publicationYear": 2021, "publicationDate": "2021-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "4(114)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Н. В. Закревська, І. О. Вишневецька", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 1, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2021.04.138", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8787/7985", "abstract": "Використовуючи наративний метод дослідження та інтерв’ю, автори розкривають деякі утаємничені сторінки космічної біографії України, визначають серйозний внесок українських підприємств і окремих інженерів-конструкторів у розробку апаратів системи управління ракетами-носіями, прицілювання космічних апаратів з орбітальними станціями і радіозв’язку під час перших польотів у космос. В статті наведено фрагмент інтерв’ю з провідним науковим співробітником Національного музею космонавтики ім. С.П. Корольова Миколою Тумаркіним, одним із колишніх членів колективу молодих конструкторів Науково-дослідного інституту електромеханічних приладів, які займалися розробленням магнітофону для потреб космічних польотів. Інтерв’ю з М. Тумаркіним проведено 10 вересня 2020 року. Авторами також проаналізовано накази Науково-дослідного інституту електромеханічних приладів про результати запуску космічного корабля «Восток» і про плани подальших робіт щодо запусків космічних кораблів цього класу. Зроблено висновок про доцільність використання наративного підходу у дослідженні внеску України у космічну галузь. Підкреслено, що використання усних спогадів у історичній науці сприятиме збереженню фактологічної пам’яті в історії науки і техніки.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2025.04.148", "doi": "10.15407/sofs2025.04.148", "title": "Науково-дослідна діяльність сільськогосподарських товариств Полтавщини у галузі тваринництва і птахівництва у кінці ХІХ — на початку ХХ ст.", "publicationYear": 2025, "publicationDate": "2025-12-22", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "4(130)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "В. А. Чалаван", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 14, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2025.04.148", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/25415/21696", "abstract": "У статті окреслено внесок сільськогосподарських товариств Полтавщини у наукове забезпечення галузі тваринництва наприкінці ХІХ — на початку ХХ ст. Наукова новизна отриманих результатів полягає в тому, що фактично вперше комплексно проаналізовано науково-дослідну діяльність зазначених товариств не лише у розвитку вівчарства і свинарства, а й конярства, сільськогосподарського птахівництва та бджільництва. Доведено, що саме члени Полтавського товариства сільського господарства та сільськогосподарської промисловості в окреслений період почали активно впроваджувати галузеве дослідництво у вівчарстві, свинарстві, конярстві та бджільництві, а члени Полтавського відділу Імператорського Російського товариства сільськогосподарського птахівництва поставили на наукову основу досліди з вирощування та вигодовування домашньої птиці. Експериментальна діяльність цих осередків сприяла становленню і розвитку племінної справи у тваринництві України, зокрема розробленню селекційних програм розведення тварин, ефективних методів і технологій відтворення цінних племінних ресурсів, практичних рекомендацій щодо застосування науково-технічних досягнень у виробництві. На Полтавському дослідному полі було організовано досліди з вигодовування тварин. Окрім напрацювання раціональних прийомів тваринництва, такі заходи сприяли придбанню племінного матеріалу та вигідному збуту тваринницької продукції як у межах країни, так і за кордон, що надавало тваринництву промислового характеру. Встановлено, що саме завдяки регіональним сільськогосподарським товариствам було сформовано програму мережі галузевих дослідних станцій, що сприяло перетворенню у 1910 р. Полтавського дослідного поля на Полтавську сільськогосподарську дослідну станцію. При ній було відкрито тваринницький відділ із лабораторією, де на постійну основу поставлено проведення серії дослідів зі свинарства (зокрема щодо схрещування свиней та їх відгодівлі різними кормами), а також дослідів із вивчення рентабельності утримання каракульських овець на штучних пасовищах і у стійлах.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2023.03.005", "doi": "10.15407/sofs2023.03.005", "title": "Наукометричне дослідження журналу «Наука та наукознавство»: до 30-річчя видання", "publicationYear": 2023, "publicationDate": "2023-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(121)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Т. М. Велентейчик, А. І. Радченко, О. І. Мриглод", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 2, "referenceCount": 14, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2023.03.005", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8664/17234", "abstract": "Стаття містить результати вперше здійсненого комплексного дослідження журналу «Наука та наукознавство» з метою визначення основних етапів, особливостей і тенденцій його розвитку. Для досягнення мети опрацьовано метадані усіх матеріалів, надрукованих у журналі протягом періоду його існування (1993—2022 рр. і перші два номери 2023 р.). Задля цього створено базу даних опублікованих у журналі матеріалів, яка враховує низку параметрів: вид публікації (наукова стаття; інформаційна або хронікальна стаття; ювілейна стаття; інтерв’ю; інформаційне та/або коротке повідомлення; публікація архівних матеріалів; рецензія; коротка хроніка), рубрика публікації, автори, країна афіліації авторів, назва і мова основного тексту матеріалу. Аналіз найчастотніших слів у назвах опублікованих у журналі матеріалів свідчить про існування в ньому усталених тематичних традицій: у журналі переважно друкуються статті, присвячені розвитку науки в Україні, місцю вітчизняної науки у світі, інноваційній діяльності. Важливими темами другого десятиліття існування журналу стали історія НАН України, її роль у розвитку країни, зокрема економічному, національний науково-технологічний потенціал. Упродовж третього десятиліття особливої ваги набули дослідження розвитку науки в Україні у світовому контексті, необхідність визначення пріоритетів наукових робіт, значення особистості в науці. Аналіз «авторського колективу» журналу виявив наявність «ядра» з 20 найактивніших авторів, які співпрацювали з журналом тривалий час, опублікували на його сторінках 326 статей, тобто 23 %. Розрахунки даних щодо мережі співавторства показали, що до найбільшої компоненти зв’язності належить лише близько чверті всіх авторів. Аналіз числових характеристик мережі для трьох десятиліть історії журналу свідчить, що попри зменшення абсолютної кількості унікальних авторів у кожний період, частка взаємопов’язаних у найбільшій компоненті вузлів поступово зростає, а частка ізольованих вузлів (без зв’язків) за останній період (2013—2023) зменшилась. Виявлено, що діяльність журналу завжди супроводжувалась організаційними і технічними удосконаленнями: створення його версії у віртуальному просторі; входження до різних реферативних і наукометричних баз даних; застосування системи цифрових ідентифікаторів журналу, авторів, наукових статей; оптимізація структури відповідно до реальних обставин і викликів.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2024.02.148", "doi": "10.15407/sofs2024.02.148", "title": "Демографічний літопис: перше 30-річчя незалежності України", "publicationYear": 2024, "publicationDate": "2024-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "2(124)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "О. С. Попович", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2024.02.148", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8601/7822", "abstract": "У рецензії на колективну монографію науковців Інституту демографії та соціальних досліджень ім. М.В. Птухи НАН України висвітлено найважливіші моменти ґрунтовного аналізу соціально-демографічної трансформації українського суспільства на зламі тисячоліть. У цій праці осмислено і узагальнено вплив на демографічну ситуацію драматичних подій і поворотів, несприятливих тенденцій і чинників, з якими зіткнулось українське суспільство на шляху утвердження національної незалежності. Цінність монографії полягає і в тому, що авторами запропоновано шляхи подолання наслідків негативних подій і тенденцій. У ній підкреслено, що протягом останніх десятиліть, тобто ще до початку повномасштабного вторгнення, Україна втрачала демографічний потенціал, а продовження тенденцій, що спричиняють депопуляцію населення, загрожує його вимиранням. Монографія містить детальний аналіз чинників демографічної кризи. В ній надано не лише комплексну характеристику зрушень у шлюбно-сімейних процесах і структурах, репродуктивній поведінці та народжуваності, смертності та тривалості життя, а й порівняння цих процесів в Україні та розвинених європейських країнах. Окремі розділи присвячені розгляду зовнішньої та внутрішньої, трудової та освітньої міграції українців. Авторами наведено дані, що свідчать про оптимістичність попередніх демографічних прогнозів щодо України. Ця монографія, що сприяє формуванню почуття відповідальності та національної самосвідомості, буде цікавою не тільки фахівцям-науковцям, а й широкому загалу тих, хто зацікавиться демографічною тематикою.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2025.03.137", "doi": "10.15407/sofs2025.03.137", "title": "Наукова діяльність Геологічного товариства Америки як платформи для консолідації світової геологічної спільноти", "publicationYear": 2025, "publicationDate": "2025-10-06", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(129)", "page": "137-149", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Г. А. Дороніна", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 17, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2025.03.137", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/22649/20968", "abstract": "У статті узагальнено результати дослідження наукової діяльності Геологічного товариства Америки (далі — товариство) від початку заснування та його ролі у розширенні співпраці та консолідації світової геологічної спільноти. Актуальність теми зумовлена зростанням глобальних викликів (зміна клімату та ін.), що потребує міжнародної кооперації вчених. Новизна дослідження полягає у комплексному аналізі еволюції діяльності товариства в бік тематики, пов’язаної з глобальними проблемами, і розширення міжнародної співпраці як майданчика для обміну досвідом та ідеями. Інформаційну базу дослідження склали документи товариства, зокрема статут, річні звіти, архіви журналів товариства, матеріали проведених щорічних конференцій, а також наукові статті членів товариства та одержувачів його грантів, опубліковані у профільних виданнях. Показано, що товариство, створене у 1888 р. у відповідь на потреби дослідження нових територій, підтримки та популяризації геологічної науки в Північній Америці, пройшло декілька етапів розвитку. На першому етапі основним його завданням було сприяння геологічним дослідженням, публікація наукових праць і створення майданчика для дискусій. Вже тоді товариство стало важливим центром вивчення змін кліматu. На наступному етапі (1930—1950-х рр.) товариство здобуло міжнародне визнання завдяки дослідженням у нових для того часу галузях, продовжило підтримувати дослідження, пов’язані з глобальними проблемами (зміною клімату, геологічними ризиками та ін.); почало залучати до співпраці іноземних учених, а також започаткувало міжнародні конференції та семінари, які стали майданчиком для обміну досвідом та ідеями. Сучасна наукова діяльність товариства спрямована на вивчення ресурсів і природних процесів Землі, розроблення стратегій адаптації до кліматичних змін, раціонального використання мінеральних, водних і енергетичних ресурсів. Товариство є організатором наукових форумів різного рівня, видавцем високорейтингових наукових журналів, засновником багатьох наукових нагород, що свідчить про його високий міжнародний статус. Отже, завдяки розширенню тематики досліджень і активній міжнародній співпраці товариство перетворилося на один із провідних світових центрів геологічної науки.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2023.04.070", "doi": "10.15407/sofs2023.04.070", "title": "Про зростання ролі вебресурсу Видавничого дому «Академперіодика» НАН України", "publicationYear": 2023, "publicationDate": "2023-04-04", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "4(122)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "З. А. Болкотун, О. М. Жук", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 3, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2023.04.070", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8687/7895", "abstract": "Розглянуто питання, пов’язані з висвітленням науково-видавничої діяльності НАН України в інформаційному просторі, зокрема через зростання ролі вебресурсу ВД «Академперіодика» НАН України у формуванні сегмента видавничої продукції Академії та популяризації наукових результатів окремих вітчизняних учених. Проаналізовано певні зміни та переваги нової відкритої системи керування вмістом сайту, на який ВД «Академперіодика» перейшов у 2022 р. задля підвищення рівня інформаційної безпеки й стабільності роботи вебресурсу, а також придатності для перегляду вмісту сайту з різних пристроїв, зокрема зі смартфонів. Надано статистичну інформацію про відвідування вебресурсу ВД «Академперіодика» за період з жовтня 2022 р. до вересня 2023 р. Зазначено, що змінюється структура відвідувань за категорією інформації: якщо раніше в пріоритеті у користувачів були методичні матеріали, то зараз зростає попит на повнотекстові файли наукових та науково-популярних книг і статей.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2019.03.122", "doi": "10.15407/sofs2019.03.122", "title": "Діяльність Центрального державного науково-технічного архіву України: 50 років формування джерельної бази історії української науки", "publicationYear": 2019, "publicationDate": "2019-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(105)", "page": "122-129", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "А. О. Алексєєнко, М. А. Балишев", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 4, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2019.03.122", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8931/8124", "abstract": "У статті висвітлено діяльність Центрального державного науково-технічного архіву України. Окреслено процес вироблення основних засад комплектування фондів архіву. Охарактеризовано інформаційний потенціал архівної науково-технічної документації, зокрема звітів про науково-дослідні роботи провідних вітчизняних науково-дослідних інститутів. Показано їх непересічну значущість при формуванні джерельної бази історії української науки.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2019.03.094", "doi": "10.15407/sofs2019.03.094", "title": "Олександр Богомолець і діяльність Академії наук України в часи його президентства (1930-1946)", "publicationYear": 2019, "publicationDate": "2019-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(105)", "page": "94-105", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Ю. К. Дупленко", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2019.03.094", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8927/8119", "abstract": "Статтю присвячено постаті О.О. Богомольця, президента Академії наук України в 1930—1946 рр. Показано, що після закінчення медичного факультету Київського університету ключову роль у формуванні світогляду майбутнього вченого відіграв учень І.І. Мечникова, професор В.В. Підвисоцький, який керував кафедрою загальної патології. Як зазначається, саме зв’язок О.О. Богомольця з мечниковською школою викликав у нього інтерес до вивчення проблем імунітету і реактивності. Описано також вплив іншого новоросійського професора, М.Г. Ушинського, який долучив О.О. Богомольця до ідей видатного патолога В.В. Пашутіна та до бактеріологічних досліджень. Значну увагу приділено ролі О.О. Богомольця у перебудові структури Академії наук України: створенню інститутів замість окремих лабораторій, кафедр і кабінетів, забезпеченню їх сучасним обладнанням та залученню до них здібних молодих вчених. Аналізуються наукові праці вченого, присвячені насамперед вивченню реактивності організму в нормальному і патологічному стані. Підкреслено, що дослідження О.О. Богомольця сприяли розвиткові майже всіх галузей патологічної фізіології. Він створив концепцію фізіологічної системи сполучної тканини, розробив і запровадив у практику антиретикулярну цитотоксичну сироватку (АЦС) як ефективний лікувальний засіб при різних захворюваннях, де потрібна стимуляція захисних сил організму і репаративних процесів.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2019.02.130", "doi": "10.15407/sofs2019.02.130", "title": "Формування в 30-х рр. ХХ ст. в Україні фундаментальних наук та їх застосувань", "publicationYear": 2019, "publicationDate": "2019-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "2(104)", "page": "130-155", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Ю. O. Храмов, Г. Л. Звонкова, O. Г. Луговський", "authorCount": 3, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 19, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2019.02.130", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8837/8030", "abstract": "Процеси формування фундаментальних наук (математики, фізики, хімії, біології, наук про Землю) та їх практичних застосувань показано в статті на тлі соціально-політичних перетворень, що відбувалися в СРСР та Україні в 30-х роках ХХ ст. В значній мірі це стало можливим завдяки концентрації досліджень у науково-дослідницьких інститутах як основних структурних одиницях науки, які з кінця 20-х рр. замінили науково-дослідницькі кафедри, комісії, комітети, кабінети тощо, створені на початку 20-х рр. керівництвом радянської України в рамках розбудови власної моделі вищої школи і науки. Розглянуто основну причину переходу до нової організаційної форми української науки — відсутність взаємних контактів між кафедрами і розпорошеність наукових сил, а відтак низька якість досліджень. Наведено докладну інформацію про виникнення та діяльність мережі спеціалізованих науково-дослідницьких інститутів у різних галузях знань, отримані в них ключові результати, а також фактори, які зумовили створення в 30-х роках фундаментальної академічної науки в Україні.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2019.02.031", "doi": "10.15407/sofs2019.02.031", "title": "Г.М. Добров в спогадах учнів і колег", "publicationYear": 2019, "publicationDate": "2019-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "2(104)", "page": "31-42", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Л. Ф. Кавуненко", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 8, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2019.02.031", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8823/8018", "abstract": "У статті на основі спогадів рідних, учнів, колег і соратників Г.М. Доброва з різних країн представлено творчий портрет Геннадія Михайловича – генератора ідей, талановитої, усебічно обдарованої особистості. Портрет доповнено інформацією про основні риси організаційної культури Г.М. Доброва, вирішувані ним завдання державного і міжнародного рівня, його міжнародну діяльність. Використано матеріали Добровських читань 12 березня 2019 р. і анкетування учнів і колег Г.М. Доброва, проведене в 1999 р.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2019.02.069", "doi": "10.15407/sofs2019.02.069", "title": "Трансформації та перспективи розвитку системи управління науково-технологічною сферою України", "publicationYear": 2019, "publicationDate": "2019-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "2(104)", "page": "69-94", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "О. А. Мех", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 3, "referenceCount": 32, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2019.02.069", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8829/8023", "abstract": "У статті подано результати аналізу поточного стану, трансформацій та перспектив розвитку сучасної системи управління науково-технологічною сферою України. В процесі дослідження уточнено окремі теоретичні та практичні аспекти функціонування систем управління, поняття і терміни, які використовуються в їх проектуванні. У прив’язці до основних чинних нормативно-правових актів надано визначення системи управління науково-технологічною сферою, сформульовано її мету і завдання. Проаналізовано наявну вітчизняну структуру управління науково-технологічною сферою, визначено її головних суб’єктів, а також процеси і етапи реформування, зокрема створення нових елементів. Окреслено основні проблеми, які пов’язані з нормативно-правовим забезпеченням, а також із дією зовнішніх і внутрішніх факторів, з їх поділом на групи. Представлено концептуальні ознаки нової архітектури системи управління науково-технологічною сферою і шляхи її виходу з кризи.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2023.03.041", "doi": "10.15407/sofs2023.03.041", "title": "Наукове цитування: історичний і теоретичний ландшафт", "publicationYear": 2023, "publicationDate": "2023-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(121)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Т. О. Ярошенко, А. Г. Жарінова", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 6, "referenceCount": 51, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2023.03.041", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8667/7877", "abstract": "Проаналізовано роль наукового цитування як форми наукової комунікації в історичному контексті та в сучасних рамках парадигми відкритої науки; узагальнено типологію та класифікацію наукового цитування; зазначено основні недоліки, зокрема в спробах оцінювання результатів наукової діяльності на підставі кількісних показників цитування. Увагу зосереджено передусім на журналоцентричному цитуванні, оскільки наукова стаття в рецензованому журналі продовжує виконувати функцію основної атомної одиниці наукової комунікації. Наукова новизна отриманих результатів полягає в сучасній інтерпретації теорії наукового цитування, зокрема з огляду на новітні тенденції щодо контекстного аналізу цитування, сучасні технології та сервіси відкритої науки, які впливають на аналіз цитування та його застосування на макрорівні. Наукове цитування посідає важливе місце у процесі глобальної наукової комунікації, адже його аналіз дає змогу не лише здійснювати бібліометричне оцінювання результатів наукової діяльності на всіх рівнях (від індивідуальних дослідників до країн), а й усебічно аналізувати ідеї, концепції, інновації, соціальні системи організації знань і навіть прогнозувати розвиток науки на макрорівні за допомогою сучасних технологій, інструментів, сервісів і стандартів. Разом із тим потрібно відповідально ставитися до показників цитування, особливо в разі їх використання як критеріїв оцінювання та фінансування досліджень, зберігаючи розумний баланс між якісною (експертною) та кількісною оцінками. Результати проведеного дослідження сприятимуть розвитку теоретичної бази вітчизняної бібліометрії та наукометрії, а також можуть бути застосовані у відповідних проєктах, зокрема щодо Відкритого українського індексу наукових цитувань (OUCI).", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2026.01.151", "doi": "10.15407/sofs2026.01.151", "title": "Симпозіум «вчені та війна»: роздуми щодо наукової співпраці українських та румунських істориків науки", "publicationYear": 2026, "publicationDate": "2026-03-25", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "1(131)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "А. С. Литвинко, E. Хелереа", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2026.01.151", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/28260/22649", "abstract": "У статті підкреслено, що міжнародне наукове співробітництво є вирішальним фактором розвитку знань, стимулювання інновацій та об'єднання інтелектуальних ресурсів країн для вирішення глобальних цивілізаційних викликів. У цьому контексті важливою є співпраця між українськими та румунськими істориками науки і техніки, яка розпочалася у 2003 році на XXX конгресі Міжнародного комітету з історії науки і техніки (ICOHTEC), членами якого українські та румунські колеги стали. 2018 р. А. Литвинко як запрошений спікер брала участь у Конгресі ICOHTEC у Брашові, Румунія. У 2019 р. історики науки й техніки з ДУ «Інститут досліджень науково-технічного потенціалу та історії науки імені Г.М. Доброва НАН України» (Київ, Україна) та Трансільванського університету (Брашов, Румунія) уклали Угоду про співпрацю, яка нині є чинною. У рамках кооперації у 2022 та 2023 роках українські науковці брали участь у семінарах Трансільванського університету та Румунського комітету з історії і філософії науки і техніки Румунської академії (CRIFST) У 2019-2025 роках румунські колеги були членами Організаційного комітету та доповідачами пленарних засідань щорічних Міжнародних конференцій молодих істориків науки, техніки і освіти та спеціалістів. Інформація про заходи публікувалася в міжнародному науковому журналі «Наука та наукознавство». Успішним етапом співпраці стала організація Українсько-Румунського симпозіуму «Вчені та війна» (керівник симпозіуму – Алла Литвинко), що відбувся в рамках 27-го Міжнародного конгресу з історії науки і техніки «Люди, місця, обміни, циркуляція» (Нова Зеландія, Данідін, 29 червня – 5 липня 2025 року). Симпозіум, який тривав 4 дні та зібрав 19 учасників, які виголосили 12 доповідей, акцентував увагу на реаліях, результатах та соціальних аспектах наукової діяльності науковців і наукових інститутів у різних сферах під час кризових періодів воєнних часів і повоєнного відновлення на прикладі Першої та Другої світових воєн, повномасштабної російсько-української війни, яка розпочалася 24 лютого 2022 року.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2019.03.003", "doi": "10.15407/sofs2019.03.003", "title": "Платформна економіка просторових бізнес-екосистем як інноваційний тренд сталого розвитку", "publicationYear": 2019, "publicationDate": "2019-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "3(105)", "page": "03-25", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "І. К. Бистряков, Д. В. Клиновий", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 9, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2019.03.003", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8915/8107", "abstract": "Розглянуто концептуальні засади розбудови сучасних територіальних бізнес-екосистем на основі природних активів з використанням засобів та механізмів платформної економіки в умовах 4-ї промислової революції. Визначено сутність бізнес-екосистемного підходу до організації взаємодій влади, бізнесу і населення на базі інформаційно-технологічних платформ мережевої колаборації економічних суб’єктів у сфері використання природних активів. Окреслено коло потенційних учасників просторових бізнес-екосистем. Висвітлено базові ознаки та драйвери платформної економіки. Згідно з проективним підходом запропоновано 4-х квадранту просторово-часову модель упорядкування сталого розвитку з нелінійним управлінським циклом «мотивація» — «проектування» — «діяльність» — «результат». У цьому контексті розглянуто чотири основні стадії формування бізнес-екосистем — господарську, проектну, програмну та платформну. В рамках платформного підходу, з позиції організації діяльності територіальних бізнес-екосистем, запропоновано базові публічно-приватні формати управління сталим просторовим розвитком.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2026.02.139", "doi": "10.15407/sofs2026.02.139", "title": "Етапи становлення національної криптографічної системи в Україні (1991—2022)", "publicationYear": 2026, "publicationDate": "2026-05-25", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "2(132)", "page": null, "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "П. О. Макаренко", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 7, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2026.02.139", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/29264/23356", "abstract": "Стаття присвячена становленню та розвитку національної криптографічної системи в період незалежності України (1991—2022), від створення нормативно-правової бази криптографічного захисту, заснування відповідних навчальних підрозділів у провідних українських університетах до розроблення власних стандартів шифрування та активної участі українських фахівців у провідних світових блокчейн-проєктах. Джерельну базу дослідження склали законодавчі та нормативно-правові акти України у сфері криптографії та кібербезпеки, національні стандарти ДСТУ, технічні специфікації та наукові публікації українських криптографів, інформація з офіційних сайтів функціональних підрозділів НТУУ «КПІ імені Ігоря Сікорського» та НТУ «Харківський політехнічний інститут», офіційна документація та матеріали спеціалізованих видань. Визначено три основні етапи інституційного становлення національної криптографічної системи: перехідний період (1992—2006) — використання пострадянських стандартів і створення Державної технічної комісії при Службі безпеки України (СБУ) і Державної служби спеціального зв’язку та захисту інформації при СБУ; період формування національної системи (2006—2014) — створення Державної служби спеціального зв’язку та захисту інформації України і проведення національного криптографічного конкурсу; період консолідації та міжнародного визнання (2014—2022) — ухвалення національних стандартів криптографічного захисту та їх подання до ISO/IEC. Особливу увагу приділено участі українських фахівців у світових блокчейн-проєктах (Bitfury, Solana, NEAR Protocol, zkSync, Trust Wallet, WhiteBIT, Hacken), що свідчить про міжнародне визнання вітчизняної криптографічної системи та здатність представників України створювати інноваційні технологічні рішення світового рівня. Встановлено, що українська криптографічна система пройшла шлях від використання пострадянських державних стандартів до створення оригінальних національних алгоритмів та інноваційних рішень світового рівня.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2018.01.114", "doi": "10.15407/sofs2018.01.114", "title": "Історико-біографічне дослідження життя та творчості українського астронома Парасковії Георгіївни Пархоменко", "publicationYear": 2018, "publicationDate": "2018-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "1(99)", "page": "114-137", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "М. А. Балишев", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 5, "referenceCount": 18, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2018.01.114", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8859/8052", "abstract": "Стаття присвячена дослідженню життя та творчості українського ученого-астрофізика Парасковії Георгіївни Пархоменко. Автором проаналізовано наукову діяльність П.Г. Пархоменко, присвячену вивченню сонячної атмосфери, теоретичним аспектам фізики Сонця, дослідженню малих планет, спостереженню за сонячними та місячними затемненнями (розглянуто публікації астронома у провідних астрономічних вітчизняних та закордонних виданнях). Основні віхи наукової біографії П.Г. Пархоменко реконструйовано на тлі становлення та розвитку Харківської астрономічної обсерваторії у 20—30-х роках ХХ ст. У статті детально розглянуто події, що пов’язані зі звільненням П.Г. Пархоменко з Харківської астрономічної обсерваторії та захистом її дисертаційної роботи, які вплинули на ритм та тематику наукової роботи астронома. Публікація основана на документах державних та відомчих архівів, а також усноісторичних матеріалах, присвячених науковій роботі П.Г. Пархоменко в Сімеїзській астрономічній обсерваторії, зібраних автором статті в межах цього дослідження. Використані архівні документи вперше вводяться до наукового обігу.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2024.04.128", "doi": "10.15407/sofs2024.04.128", "title": "Науковий простір академіка О.О. Созінова (1930—2018): вплив визначних діячів аграрної науки на формування вченого (друга половина ХХ століття)", "publicationYear": 2024, "publicationDate": "2024-12-12", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "4(126)", "page": "128-140", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "С. В. Нижник", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 19, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2024.04.128", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/15559/17851", "abstract": "На другу половину ХХ ст. припав початок наукової діяльності визначного генетика, селекціонера, біотехнолога, агроеколога, організатора генетико-селекційної та аграрної науки, аграрної освіти в Україні, академіка Національної академії наук України, Національної академії аграрних наук України і низки іноземних академій Олексія Олексійовича Созінова. З ім’ям О.О. Созінова пов’язані нові напрями сучасної загальної та молекулярної генетики, селекції, еволюції тварин і рослин; він активно працював над проблемами агросфери ХХІ ст., збереження біорізноманітності та довкілля в контексті сталого розвитку. У статті висвітлено вплив учених у галузі сільськогосподарської науки Я.Я. Вербіна, П.Х. Гаркавого, В.Ф. Кириченка, О.С. Мусійка, А.С. Сапєгіна та М.П. Дубініна на становлення творчих пошуків доктора сільськогосподарських наук, професора, академіка О.О. Созінова (1930—2018). Методологія дослідження ґрунтується на використанні історичних і загальнонаукових методів, зокрема систематизації, біографічного методу. На прикладі життєпису О.О. Созінова показано вплив цих науковців на перетворення студента на дослідника, а згодом на колегу, який став, попри обставини, вченим зі світовим ім’ям. Виділено основні періоди формування наукового світогляду О.О. Созінова (здобуття фахової освіти в Одеському сільськогосподарському інституті (1957—1962); виробнича діяльність, підготовка та захист дисертаційного дослідження (1962—1974)), пріоритетні напрями його досліджень. Висвітлено зв’язки О.О. Созінова зі згаданими вище представниками аграрної науки, що дало йому змогу розширити наукові контакти і комунікації з ними. Доведено вплив Я.Я. Вербіна, П.Х. Гаркавого, В.Ф. Кириченка, О.С. Мусійка, А.С. Сапєгіна, М.П. Дубініна на формування особистості, професійне становлення і кар’єрне зростання О.О. Созінова. Обґрунтовано пріоритетність і практичну значимість унікальних наукових досліджень і розробок учених, які заклали фундамент для розвитку селекційно-генетичної науки.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2023.01.047", "doi": "10.15407/sofs2023.01.047", "title": "Biotechnology for Cleaning up Soils from Explosives", "publicationYear": 2023, "publicationDate": "2023-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "1(119)", "page": "47-56", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "G. Kvesitadze, G. Khatisashvili", "authorCount": 2, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 29, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2023.01.047", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8625/7844", "abstract": "This article discusses the issue of environmental pollution caused by explosives. Nitro-organic substances (trotyl, hexogen, etc.), as well as highly toxic carcinogenic compounds contaminate the soil, groundwater and reservoirs at sites of military activities. Due to their composition and stable structure, explosives basically do not undergo complete natural transformations under biotic conditions even for decades, often getting into the food chain causing serious pathologies. The presented investigation is based on use of a collection of microorganisms, comprising up to 8 thousand strains of bacteria, filamentous fungi, actinomycetes, isolated from various soil and climatic zones and locations of the former Soviet military units, including shooting ranges. Model experiments were conducted in a lab, and small field conditions (100 m2). At the first stage, selectively chosen rhizospheric microorganisms, known by their predominantly determined detoxification activity, were introduced into the soil contaminated with explosives, to carry out the primary transformation of explosives, transforming into more hydrophilic and less toxic compounds for further transformation. At the second stage, plants were sown on soil that was artificially contaminated with explosives, and then treated by selected microorganisms. These plants assimilated, carried out further degradation of toxic components and products of their partial transformation, and transformed partially degraded explosives into above ground parts or mineralized them. At the third stage, plants containing toxicity were treated with microscopic fungi which had powerful extracellular enzyme systems that degrade the remaining part of toxic components. As a result, it has been established that in 30—45 days, i.e. within one summer season, it is possible to achieve 70—80 % soil clearance from toxic compounds. The biotechnology itself is environmentally friendly and is based on the use of non-toxic forms of microorganisms that are isolated from the soil.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2023.01.057", "doi": "10.15407/sofs2023.01.057", "title": "Соціальні та гносеологічні виклики і трансформації наукового етосу (на прикладі аналізу пандемії COVID-19)", "publicationYear": 2023, "publicationDate": "2023-10-07", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "1(119)", "page": "57-68", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Л. В. Рижко", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 0, "referenceCount": 12, "isOpenAccess": true, "licenseUrl": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2023.01.057", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/8626/7845", "abstract": "На основі аналізу оглядів ЮНЕСКО, ОЕСР, результатів опитування «Академічна реакція на COVID-19», проведеного Міждисциплінарним науковим журналом «Frontiers in Public Health», інших джерел, присвячених проблемам науки, показано, що в умовах пошуку виходу з надзвичайних ситуацій, як-то пандемії та стихійні лиха, посилюється гносеологічна, праксеологічна та соціальна роль науки, зростає потреба в експертних рекомендаціях учених, активно використовуються методи та принципи «відкритої науки», пожвавлюється міжнародна співпраця та державно-приватне партнерство. Водночас експертам доводиться працювати в умовах «епістемологічної невизначеності», тобто неповної інформації, мінливої ситуації, обмеженого часу та іноді нечітко поставлених завдань. Тому висновки і рекомендації часто доводиться корегувати, що породжує проблеми довіри суспільства до науки, труднощі комунікації з владою. Важливим заходом, що сприятиме нівелюванню негативних явищ, є покращення наукової грамотності суспільства, зокрема керівників різних рівнів. Представники влади, засобів масової інформації та громадськості повинні володіти не лише фактологічними знаннями, а й компетенціями у методології науки: вони мають відрізняти завершені дослідження від попередніх результатів, експертні оцінки — від наукової та політичної публіцистики, а також розуміти логіку наукових дебатів і формування наукового консенсусу. Окрім того, пандемія провокує численні соціальні виклики і потребує використання міждисциплінарних знань, у т. ч. в соціальних і гуманітарних галузях, оскільки нагальними стають також проблеми психічного здоров’я, освіти, економіки, культури. Науковий етос в умовах соціальних і гносеологічних викликів є синтезом усіх відомих норм, але у формі, необхідній для розроблення ефективних механізмів подолання надзвичайних ситуацій. Набувають більшого значення норми колективізму, універсалізму та скептицизму, які уможливлюють колективний пошук способів подолання недуги та критичний розгляд усіх пропозицій, коли головна увага зосереджується на проблемах, пов’язаних із надзвичайними ситуаціями, активізуються консультативні та експертні функції науки.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}
{"paperId": "10.15407/sofs2025.01.116", "doi": "10.15407/sofs2025.01.116", "title": "Міжнародна науково-практична конференція «Глобальні юридичні навички» (4–10 червня 2024, Барі, Італія", "publicationYear": 2025, "publicationDate": "2025-03-27", "type": "journal-article", "publisher": "National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)", "containerTitle": "Science and Science of Science", "volume": null, "issue": "1(127)", "page": "116-125", "issn": "2707-0085, 1560-4926", "isbn": null, "authors": "Н. О. Максименцева", "authorCount": 1, "firstAuthorAffiliation": null, "isReferencedByCount": 1, "referenceCount": 0, "isOpenAccess": true, "licenseUrl": "http://creativecommons.org/licenses/by-nc-nd/4.0/", "funderNames": null, "funderIds": null, "url": "https://doi.org/10.15407/sofs2025.01.116", "pdfUrl": "https://nasu-periodicals.org.ua/index.php/sofs/article/download/17303/16722", "abstract": "На сьогодні досить актуально постало питання реформування юридичної освіти, запровадження нових підходів до підготовки фахівців та наявності у них практичних знань та навичок. На рівні законопроєкту розроблена Концепція реформування юридичної освіти в Україні і застосування найкращого світового досвіду та напрацювань є вимогою часу. Україна бере активну участь у міжнародній науковій діяльності і питання викликів юридичної освіти та пошуку шляхів їх потребує залучення кращого світового досвіду та практик. На міжнародній конференції було представлено основні досягнення різних наукових шкіл Європи (Італії Чехії, Німеччини) та США у поширенні прикладних юридичних знань серед студентів-юристів. Конференція включала заходи, панельні дискусії та обмін досвідом щодо юридичної науки та освіти, навчання студентів-юристів, проведення переговорів, юридичної англійської мови, юридичного англійського письма та складання ділових документів. Серед інших обговорених на конференції питань – застосування інструментів AI у роботі зі студентами та у формуванні в них певних навичок і здібностей; застосування підходів AcrossCultures для формування навичок спілкування юристів-практиків із різних країн; врахування особливостей та традицій різних країн та культурних груп; тематика GetYourStudentsSpeaking – розвиток навичок усного спілкування; формування письмових здібностей юриста (legal writing); поширення досвіду Use Data for Social Change; використання нових підходів до формування практичних навичок у студентів та формування соціальної відповідальності; психологічний комфорт і позитивне мислення студентів, доброзичливе ставлення в колективі; поширення досвіду використання практичних кейсів і формування у студентів навичок роботи з ними.", "subject": null, "language": null, "_run_id": "jotZKPIm0Os3auk3v", "_dataset_id": "hbG4wJ2u3sFJ89inA"}