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42343123 | 10.1038/s41586-026-10625-1 | Genetic diversity of late Neanderthals in northwestern Europe | Archaeological, osteological and genetic evidence suggests that Neanderthals lived in small groups1,2; however, less is known about whether these groups were part of isolated communities or belonged to larger, well-connected populations3. The dense concentration of broadly contemporaneous Neanderthal sites in the Meuse... | Nature | Nature | 2026 Jul | 2,026 | [
"Bossoms Mesa A",
"Essel E",
"Peyrégne S",
"Sümer AP",
"Iasi LNM",
"Heide C",
"Popli D",
"de Filippo C",
"Gansauge MT",
"Gerullat L",
"Lippik L",
"Nagel S",
"Nickel B",
"Schellbach B",
"Schmidt A",
"Visagie J",
"Weihmann A",
"Zeberg H",
"Zorn J",
"Rougier H",
"Crevecoeur I",
... | Bossoms Mesa A | Hajdinjak M | [
"Animals",
"Female",
"Humans",
"Male",
"Belgium",
"France",
"Gene Flow",
"Genetic Variation",
"History, Ancient",
"Neanderthals",
"Phylogeny"
] | [
"Journal Article"
] | 655 | 8122 | 409-417 | pmc-id: PMC13345965; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/42343123/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
42247510 | 10.1126/sciadv.ady1666 | Regulation of NAT1 activity in modern humans by a novel phosphorylation site | N-acetyltransferase 1 (NAT1) is an enzyme that acetylates certain drugs and carcinogens and is involved in folate metabolism. Some NAT1 variants are associated with susceptibility to cancer and birth defects. We show that while nearly all present-day humans carry a valine residue at position 149 and a serine residue at... | Sci Adv | Science advances | 2026 Jun 5 | 2,026 | [
"Fast L",
"Alberro ML",
"Rakava E",
"Ågren R",
"Riesenberg S",
"Huttner WB",
"Kelso J",
"Pääbo S",
"Zeberg H"
] | Fast L | Zeberg H | [
"Humans",
"Phosphorylation",
"Animals",
"Arylamine N-Acetyltransferase",
"Isoenzymes",
"Neanderthals",
"Female"
] | [
"Journal Article"
] | 12 | 23 | eady1666 | pmc-id: PMC13240207; | 2375-2548 | eng | https://pubmed.ncbi.nlm.nih.gov/42247510/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
41871248 | 10.1073/pnas.2534576123 | A high-coverage Neandertal genome from the Altai Mountains reveals population structure among Neandertals | We present a genome sequenced to ~37-fold genomic coverage from an approximately 110,000-y-old male Neandertal from Denisova Cave in the Altai Mountains and analyze it together with previously published Neandertal genomes of high quality. We show that he belonged to a population more closely related to a ~120,000-y-old... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2026 Mar 31 | 2,026 | [
"Massilani D",
"Peyrégne S",
"Iasi LNM",
"de Filippo C",
"Mafessoni F",
"Bossoms Mesa A",
"Sümer AP",
"Swiel Y",
"Popli D",
"Silverman S",
"Boyle MJ",
"Kozlikin MB",
"Shunkov MV",
"Derevianko AP",
"Higham T",
"Douka K",
"Meyer M",
"Zeberg H",
"Kelso J",
"Pääbo S"
] | Massilani D | Pääbo S | [
"Animals",
"Neanderthals",
"Male",
"Gene Flow",
"Genome",
"Humans",
"Gene Frequency",
"Genetics, Population"
] | [
"Journal Article"
] | 123 | 13 | e2534576123 | pmc-id: PMC13037865; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/41871248/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
41610256 | 10.1126/science.adw9154 | The evolution of gene regulation in mammalian cerebellum development | Gene regulatory changes are considered major drivers of evolutionary innovations, including the cerebellum's expansion during human evolution, yet they remain largely unexplored. In this study, we combined single-nucleus measurements of gene expression and chromatin accessibility from six mammals (human, bonobo, macaqu... | Science | Science (New York, N.Y.) | 2026 Jan 29 | 2,026 | [
"Sarropoulos I",
"Sepp M",
"Yamada T",
"Schäfer PSL",
"Trost N",
"Schmidt J",
"Schneider C",
"Drummer C",
"Mißbach S",
"Taskiran II",
"Hecker N",
"Bravo González-Blas C",
"Frömel R",
"Joshi P",
"Leushkin E",
"Arnskötter F",
"Leiss K",
"Okonechnikov K",
"Lisgo S",
"Palkovits M",... | Sarropoulos I | Kaessmann H | [
"Animals",
"Cerebellum",
"Humans",
"Mice",
"Gene Expression Regulation, Developmental",
"Gene Regulatory Networks",
"Evolution, Molecular",
"Chromatin",
"Mammals",
"Biological Evolution"
] | [
"Journal Article"
] | 391 | 6784 | eadw9154 | pmc-id: PMC7618896;manuscript-id: EMS212840; | 0036-8075 | eng | https://pubmed.ncbi.nlm.nih.gov/41610256/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
41361167 | 10.1038/s41467-025-66896-1 | Search-and-remove genome editing allows selection of cells by DNA sequence | The selection of cells that have acquired a desired gene edit is often done by the introduction of additional genes that confer drug resistance or encode fluorophores. However, such marker genes can have unintended physiological effects and are not compatible with editing of single nucleotides. Here, we present SNIPE, ... | Nat Commun | Nature communications | 2025 Dec 8 | 2,025 | [
"Fast L",
"Omar M",
"Kanis P",
"Schaffer T",
"Chowdhury D",
"Rakava E",
"Pääbo S",
"Riesenberg S"
] | Fast L | Riesenberg S | [
"Gene Editing",
"Humans",
"Animals",
"CRISPR-Cas Systems",
"Neanderthals",
"Mutation, Missense",
"CRISPR-Associated Protein 9",
"Base Sequence",
"Cell Line, Tumor"
] | [
"Journal Article"
] | 16 | 1 | 10985 | pmc-id: PMC12689631; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/41361167/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
40920634 | 10.1016/j.cell.2025.05.040 | Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium | Denisovans have yet to be directly associated with a hominin cranium, limiting our understanding of their morphology and geographical distribution. We have attempted to retrieve DNA from a nearly complete Middle Pleistocene cranium from Harbin (>146 ka), northeastern China. Although no DNA could be retrieved from a too... | Cell | Cell | 2025 Jul 24 | 2,025 | [
"Fu Q",
"Cao P",
"Dai Q",
"Bennett EA",
"Feng X",
"Yang MA",
"Ping W",
"Pääbo S",
"Ji Q"
] | Fu Q | Ji Q | [
"DNA, Mitochondrial",
"Dental Calculus",
"Animals",
"Fossils",
"Hominidae",
"Skull",
"China",
"Phylogeny",
"DNA, Ancient",
"Humans"
] | [
"Journal Article"
] | 188 | 15 | 3919-3926.e9 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/40920634/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
40758872 | 10.1073/pnas.2508540122 | The activity and expression of adenylosuccinate lyase were reduced during modern human evolution, affecting brain and behavior | Adenylosuccinate lyase (ADSL), an enzyme that is crucial for purine biosynthesis, carries an amino acid substitution that is present in almost all humans today but absent in Neandertals and Denisovans. This substitution reduces the stability of the enzyme, but what functional consequences it has are unknown. Here, we s... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2025 Aug 12 | 2,025 | [
"Ju XC",
"Lee SY",
"Ågren R",
"Machado LC",
"Xing J",
"Azama C",
"Roy MC",
"Endo T",
"Huttner W",
"Siepel A",
"Fukunaga I",
"Zeberg H",
"Pääbo S"
] | Ju XC | Pääbo S | [
"Adenylosuccinate Lyase",
"Animals",
"Humans",
"Brain",
"Mice",
"Female",
"Evolution, Molecular",
"Amino Acid Substitution",
"Biological Evolution",
"Behavior, Animal"
] | [
"Journal Article"
] | 122 | 32 | e2508540122 | pmc-id: PMC12358879; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/40758872/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
40640132 | 10.1038/s41467-025-61605-4 | Muscle AMP deaminase activity was lower in Neandertals than in modern humans | The enzyme AMPD1 is expressed in skeletal muscle and is involved in ATP production. All available Neandertal genomes carry a lysine-to-isoleucine substitution at position 287 in AMPD1. This variant, which occurs at an allele frequency of 0-8% outside Africa, was introduced to modern humans by gene flow from Neandertals... | Nat Commun | Nature communications | 2025 Jul 10 | 2,025 | [
"Macak D",
"Lee SY",
"Nyman T",
"Ampah-Korsah H",
"Strandback E",
"Pääbo S",
"Zeberg H"
] | Macak D | Zeberg H | [
"Animals",
"Neanderthals",
"Humans",
"AMP Deaminase",
"Muscle, Skeletal",
"Mice",
"Gene Frequency"
] | [
"Journal Article"
] | 16 | 1 | 6371 | pmc-id: PMC12246493; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/40640132/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
40399313 | 10.1038/s41467-025-60140-6 | Pleistocene chronology and history of hominins and fauna at Denisova Cave | Denisova Cave in southern Siberia is the only site known to have been occupied by Denisovans, Neanderthals and modern humans. The cave consists of three chambers (Main, East and South), with the archaeological assemblages and remains of hominins, fauna and flora recovered from Main and East Chambers being the most thor... | Nat Commun | Nature communications | 2025 May 21 | 2,025 | [
"Jacobs Z",
"Zavala EI",
"Li B",
"O'Gorman K",
"Shunkov MV",
"Kozlikin MB",
"Derevianko AP",
"Uliyanov VA",
"Goldberg P",
"Agadjanian AK",
"Vasiliev SK",
"Brink F",
"Peyrégne S",
"Slon V",
"Pääbo S",
"Kelso J",
"Meyer M",
"Roberts RG"
] | Jacobs Z | Roberts RG | [
"Animals",
"Caves",
"Siberia",
"Hominidae",
"DNA, Mitochondrial",
"Fossils",
"Humans",
"Neanderthals",
"Geologic Sediments",
"Archaeology",
"DNA, Ancient",
"Mammals",
"History, Ancient"
] | [
"Journal Article",
"Historical Article"
] | 16 | 1 | 4738 | pmc-id: PMC12095498; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/40399313/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
38739836 | 10.1073/pnas.2402159121 | The modern human aryl hydrocarbon receptor is more active when ancestralized by genome editing | The aryl hydrocarbon receptor (AHR) is a transcription factor that has many functions in mammals. Its best known function is that it binds aromatic hydrocarbons and induces the expression of cytochrome P450 genes, which encode enzymes that metabolize aromatic hydrocarbons and other substrates. All present-day humans ca... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2024 May 28 | 2,024 | [
"Helmbrecht N",
"Lackner M",
"Maricic T",
"Pääbo S"
] | Helmbrecht N | Pääbo S | [
"Receptors, Aryl Hydrocarbon",
"Humans",
"Gene Editing",
"Animals",
"Basic Helix-Loop-Helix Proteins",
"Evolution, Molecular",
"Pan troglodytes",
"Neanderthals",
"Ligands"
] | [
"Journal Article"
] | 121 | 22 | e2402159121 | pmc-id: PMC11145187; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/38739836/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
38658571 | 10.1038/s41467-024-47437-8 | Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development | Metabolism has recently emerged as a major target of genes implicated in the evolutionary expansion of human neocortex. One such gene is the human-specific gene ARHGAP11B. During human neocortex development, ARHGAP11B increases the abundance of basal radial glia, key progenitors for neocortex expansion, by stimulating ... | Nat Commun | Nature communications | 2024 Apr 24 | 2,024 | [
"Xing L",
"Gkini V",
"Nieminen AI",
"Zhou HC",
"Aquilino M",
"Naumann R",
"Reppe K",
"Tanaka K",
"Carmeliet P",
"Heikinheimo O",
"Pääbo S",
"Huttner WB",
"Namba T"
] | Xing L | Namba T | [
"Neocortex",
"Humans",
"Animals",
"Glutamate Dehydrogenase",
"GTPase-Activating Proteins",
"Ketoglutaric Acids",
"Neuroglia",
"Glutamic Acid",
"Mitochondria",
"Mice",
"Citric Acid Cycle",
"Female"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 15 | 1 | 3468 | pmc-id: PMC11043075; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/38658571/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
38367615 | 10.1016/j.cell.2023.12.029 | The genetic changes that shaped Neandertals, Denisovans, and modern humans | Modern human ancestors diverged from the ancestors of Neandertals and Denisovans about 600,000 years ago. Until about 40,000 years ago, these three groups existed in parallel, occasionally met, and exchanged genes. A critical question is why modern humans, and not the other two groups, survived, became numerous, and de... | Cell | Cell | 2024 Feb 29 | 2,024 | [
"Zeberg H",
"Jakobsson M",
"Pääbo S"
] | Zeberg H | Pääbo S | [
"Animals",
"Humans",
"Neanderthals",
"Research",
"Hominidae",
"Human Genetics"
] | [
"Journal Article",
"Review"
] | 187 | 5 | 1047-1058 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/38367615/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
37474806 | 10.1038/s41592-023-01949-1 | Efficient high-precision homology-directed repair-dependent genome editing by HDRobust | Homology-directed repair (HDR), a method for repair of DNA double-stranded breaks can be leveraged for the precise introduction of mutations supplied by synthetic DNA donors, but remains limited by low efficiency and off-target effects. In this study, we report HDRobust, a high-precision method that, via the combined t... | Nat Methods | Nature methods | 2023 Sep | 2,023 | [
"Riesenberg S",
"Kanis P",
"Macak D",
"Wollny D",
"Düsterhöft D",
"Kowalewski J",
"Helmbrecht N",
"Maricic T",
"Pääbo S"
] | Riesenberg S | Pääbo S | [
"Humans",
"Gene Editing",
"CRISPR-Cas Systems",
"Recombinational DNA Repair",
"DNA Breaks, Double-Stranded",
"DNA End-Joining Repair",
"DNA"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 20 | 9 | 1388-1399 | pmc-id: PMC10482697; | 1548-7091 | eng | https://pubmed.ncbi.nlm.nih.gov/37474806/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
37315093 | 10.1093/molbev/msad130 | Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals | Dupuytren's disease is characterized by fingers becoming permanently bent in a flexed position. Whereas people of African ancestry are rarely afflicted by Dupuytren's disease, up to ∼30% of men over 60 years suffer from this condition in northern Europe. Here, we meta-analyze 3 biobanks comprising 7,871 cases and 645,8... | Mol Biol Evol | Molecular biology and evolution | 2023 Jun 1 | 2,023 | [
"Ågren R",
"Patil S",
"Zhou X",
"FinnGen.",
"Sahlholm K",
"Pääbo S",
"Zeberg H"
] | Ågren R | Zeberg H | [
"Animals",
"Humans",
"Male",
"Alleles",
"Dupuytren Contracture",
"Neanderthals",
"Risk Factors"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 40 | 6 | null | pmc-id: PMC10266526; | 0737-4038 | eng | https://pubmed.ncbi.nlm.nih.gov/37315093/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
37138083 | 10.1038/s41586-023-06035-2 | Ancient human DNA recovered from a Palaeolithic pendant | Artefacts made from stones, bones and teeth are fundamental to our understanding of human subsistence strategies, behaviour and culture in the Pleistocene. Although these resources are plentiful, it is impossible to associate artefacts to specific human individuals1 who can be morphologically or genetically characteriz... | Nature | Nature | 2023 Jun | 2,023 | [
"Essel E",
"Zavala EI",
"Schulz-Kornas E",
"Kozlikin MB",
"Fewlass H",
"Vernot B",
"Shunkov MV",
"Derevianko AP",
"Douka K",
"Barnes I",
"Soulier MC",
"Schmidt A",
"Szymanski M",
"Tsanova T",
"Sirakov N",
"Endarova E",
"McPherron SP",
"Hublin JJ",
"Kelso J",
"Pääbo S",
"Hajdi... | Essel E | Meyer M | [
"Animals",
"Female",
"Humans",
"Archaeology",
"Bone and Bones",
"Deer",
"DNA, Ancient",
"DNA, Mitochondrial",
"History, Ancient",
"Siberia",
"Tooth",
"Caves",
"Russia"
] | [
"Historical Article",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 618 | 7964 | 328-332 | pmc-id: PMC10247382; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/37138083/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
36893240 | 10.1126/science.adf2212 | Response to Comment on "Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals" | Herai et al. discuss the known fact that a low percentage of modern humans who lack any overt phenotypes carry the ancestral TKTL1 allele. Our paper demonstrates that the amino acid substitution in TKTL1 increases neural progenitor cells and neurogenesis in the developing brain. It is another question if, and to what e... | Science | Science (New York, N.Y.) | 2023 Mar 10 | 2,023 | [
"Pinson A",
"Maricic T",
"Zeberg H",
"Pääbo S",
"Huttner WB"
] | Pinson A | Huttner WB | [
"Animals",
"Humans",
"Neanderthals",
"Neocortex",
"Neural Stem Cells",
"Neurogenesis",
"Transketolase"
] | [
"Journal Article"
] | 379 | 6636 | eadf2212 | null | 0036-8075 | eng | https://pubmed.ncbi.nlm.nih.gov/36893240/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
36879029 | 10.1038/s41598-023-30663-3 | Functional dissection of two amino acid substitutions unique to the human FOXP2 protein | The transcription factor forkhead box P2 (FOXP2) is involved in the development of language and speech in humans. Two amino acid substitutions (T303N, N325S) occurred in the human FOXP2 after the divergence from the chimpanzee lineage. It has previously been shown that when they are introduced into the FOXP2 protein of... | Sci Rep | Scientific reports | 2023 Mar 6 | 2,023 | [
"Bornschein U",
"Zeberg H",
"Enard W",
"Hevers W",
"Pääbo S"
] | Bornschein U | Pääbo S | [
"Humans",
"Animals",
"Mice",
"Amino Acid Substitution",
"Blood Group Antigens",
"Corpus Striatum",
"Dissection",
"Extremities",
"Pan troglodytes",
"Forkhead Transcription Factors",
"Repressor Proteins"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 13 | 1 | 3747 | pmc-id: PMC9988825; | 2045-2322 | eng | https://pubmed.ncbi.nlm.nih.gov/36879029/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
36620901 | 10.1093/nar/gkac1254 | Detection of unintended on-target effects in CRISPR genome editing by DNA donors carrying diagnostic substitutions | CRISPR nucleases can introduce double-stranded DNA breaks in genomes at positions specified by guide RNAs. When repaired by the cell, this may result in the introduction of insertions and deletions or nucleotide substitutions provided by exogenous DNA donors. However, cellular repair can also result in unintended on-ta... | Nucleic Acids Res | Nucleic acids research | 2023 Mar 21 | 2,023 | [
"Lackner M",
"Helmbrecht N",
"Pääbo S",
"Riesenberg S"
] | Lackner M | Riesenberg S | [
"Humans",
"Clustered Regularly Interspaced Short Palindromic Repeats",
"CRISPR-Cas Systems",
"DNA",
"Gene Editing",
"Nucleotides",
"Embryonic Stem Cells",
"DNA Mutational Analysis"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 51 | 5 | e26 | pmc-id: PMC10018342; | 0305-1048 | eng | https://pubmed.ncbi.nlm.nih.gov/36620901/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
36544022 | 10.1038/s41586-022-05547-7 | The molecular evolution of spermatogenesis across mammals | The testis produces gametes through spermatogenesis and evolves rapidly at both the morphological and molecular level in mammals1-6, probably owing to the evolutionary pressure on males to be reproductively successful7. However, the molecular evolution of individual spermatogenic cell types across mammals remains large... | Nature | Nature | 2023 Jan | 2,023 | [
"Murat F",
"Mbengue N",
"Winge SB",
"Trefzer T",
"Leushkin E",
"Sepp M",
"Cardoso-Moreira M",
"Schmidt J",
"Schneider C",
"Mößinger K",
"Brüning T",
"Lamanna F",
"Belles MR",
"Conrad C",
"Kondova I",
"Bontrop R",
"Behr R",
"Khaitovich P",
"Pääbo S",
"Marques-Bonet T",
"Grützn... | Murat F | Kaessmann H | [
"Animals",
"Male",
"Chromatin",
"Evolution, Molecular",
"Mammals",
"Meiosis",
"Spermatogenesis",
"Testis",
"Transcriptome",
"Single-Cell Analysis",
"Birds",
"Primates",
"Gene Expression Regulation",
"Spermatogonia",
"Sertoli Cells",
"X Chromosome",
"Y Chromosome",
"Dosage Compensat... | [
"Comparative Study",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 613 | 7943 | 308-316 | pmc-id: PMC9834047; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/36544022/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
36261548 | 10.1038/s41586-022-05283-y | Genetic insights into the social organization of Neanderthals | Genomic analyses of Neanderthals have previously provided insights into their population history and relationship to modern humans1-8, but the social organization of Neanderthal communities remains poorly understood. Here we present genetic data for 13 Neanderthals from two Middle Palaeolithic sites in the Altai Mounta... | Nature | Nature | 2022 Oct | 2,022 | [
"Skov L",
"Peyrégne S",
"Popli D",
"Iasi LNM",
"Devièse T",
"Slon V",
"Zavala EI",
"Hajdinjak M",
"Sümer AP",
"Grote S",
"Bossoms Mesa A",
"López Herráez D",
"Nickel B",
"Nagel S",
"Richter J",
"Essel E",
"Gansauge M",
"Schmidt A",
"Korlević P",
"Comeskey D",
"Derevianko AP",... | Skov L | Peter BM | [
"Animals",
"Female",
"Humans",
"Caves",
"Genome",
"Hybridization, Genetic",
"Neanderthals",
"Siberia",
"DNA, Mitochondrial",
"Y Chromosome",
"Male",
"Family",
"Homozygote"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 610 | 7932 | 519-525 | pmc-id: PMC9581778; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/36261548/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
36074851 | 10.1126/science.abl6422 | Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals | Neanderthal brains were similar in size to those of modern humans. We sought to investigate potential differences in neurogenesis during neocortex development. Modern human transketolase-like 1 (TKTL1) differs from Neanderthal TKTL1 by a lysine-to-arginine amino acid substitution. Using overexpression in developing mou... | Science | Science (New York, N.Y.) | 2022 Sep 9 | 2,022 | [
"Pinson A",
"Xing L",
"Namba T",
"Kalebic N",
"Peters J",
"Oegema CE",
"Traikov S",
"Reppe K",
"Riesenberg S",
"Maricic T",
"Derihaci R",
"Wimberger P",
"Pääbo S",
"Huttner WB"
] | Pinson A | Huttner WB | [
"Animals",
"Ependymoglial Cells",
"Ferrets",
"Humans",
"Mice",
"Neanderthals",
"Neocortex",
"Neurogenesis",
"Transketolase"
] | [
"Journal Article"
] | 377 | 6611 | eabl6422 | null | 0036-8075 | eng | https://pubmed.ncbi.nlm.nih.gov/36074851/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
35905187 | 10.1126/sciadv.abn7702 | Longer metaphase and fewer chromosome segregation errors in modern human than Neanderthal brain development | Since the ancestors of modern humans separated from those of Neanderthals, around 100 amino acid substitutions spread to essentially all modern humans. The biological significance of these changes is largely unknown. Here, we examine all six such amino acid substitutions in three proteins known to have key roles in kin... | Sci Adv | Science advances | 2022 Jul 29 | 2,022 | [
"Mora-Bermúdez F",
"Kanis P",
"Macak D",
"Peters J",
"Naumann R",
"Xing L",
"Sarov M",
"Winkler S",
"Oegema CE",
"Haffner C",
"Wimberger P",
"Riesenberg S",
"Maricic T",
"Huttner WB",
"Pääbo S"
] | Mora-Bermúdez F | Pääbo S | [
"Animals",
"Brain",
"Chromosome Segregation",
"Hominidae",
"Humans",
"Kinesins",
"Metaphase",
"Mice",
"Neanderthals"
] | [
"Journal Article"
] | 8 | 30 | eabn7702 | pmc-id: PMC9337762; | 2375-2548 | eng | https://pubmed.ncbi.nlm.nih.gov/35905187/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
35816093 | 10.7554/eLife.75464 | The evolutionary history of human spindle genes includes back-and-forth gene flow with Neandertals | Proteins associated with the spindle apparatus, a cytoskeletal structure that ensures the proper segregation of chromosomes during cell division, experienced an unusual number of amino acid substitutions in modern humans after the split from the ancestors of Neandertals and Denisovans. Here, we analyze the history of t... | Elife | eLife | 2022 Jul 11 | 2,022 | [
"Peyrégne S",
"Kelso J",
"Peter BM",
"Pääbo S"
] | Peyrégne S | Pääbo S | [
"Animals",
"Biological Evolution",
"Black People",
"Fossils",
"Gene Flow",
"Hominidae",
"Humans",
"Neanderthals"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 11 | null | null | pmc-id: PMC9273211; | 2050-084X | eng | https://pubmed.ncbi.nlm.nih.gov/35816093/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
35780191 | 10.1038/s41397-022-00284-6 | The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals | Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes CYP2C8 and CYP2C9 on chromosome 10 exhibits linkage disequilibrium between the CYP2C8*3 and CYP2C9*2 alleles, forming a haplotype of ~300 kilobases. This hap... | Pharmacogenomics J | The pharmacogenomics journal | 2022 Jul | 2,022 | [
"Haeggström S",
"Ingelman-Sundberg M",
"Pääbo S",
"Zeberg H"
] | Haeggström S | Zeberg H | [
"Animals",
"Aryl Hydrocarbon Hydroxylases",
"Cytochrome P-450 CYP2C8",
"Cytochrome P-450 CYP2C9",
"Gene Frequency",
"Haplotypes",
"Humans",
"Neanderthals"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 22 | 4 | 247-249 | pmc-id: PMC9363273; | 1470-269X | eng | https://pubmed.ncbi.nlm.nih.gov/35780191/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
35780170 | 10.1186/s13395-022-00299-4 | High-throughput muscle fiber typing from RNA sequencing data | Skeletal muscle fiber type distribution has implications for human health, muscle function, and performance. This knowledge has been gathered using labor-intensive and costly methodology that limited these studies. Here, we present a method based on muscle tissue RNA sequencing data (totRNAseq) to estimate the distribu... | Skelet Muscle | Skeletal muscle | 2022 Jul 2 | 2,022 | [
"Oskolkov N",
"Santel M",
"Parikh HM",
"Ekström O",
"Camp GJ",
"Miyamoto-Mikami E",
"Ström K",
"Mir BA",
"Kryvokhyzha D",
"Lehtovirta M",
"Kobayashi H",
"Kakigi R",
"Naito H",
"Eriksson KF",
"Nystedt B",
"Fuku N",
"Treutlein B",
"Pääbo S",
"Hansson O"
] | Oskolkov N | Hansson O | [
"Base Sequence",
"Humans",
"Muscle Fibers, Skeletal",
"RNA",
"Sequence Analysis, RNA",
"Exome Sequencing"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 12 | 1 | 16 | pmc-id: PMC9250227; | 2044-5040 | eng | https://pubmed.ncbi.nlm.nih.gov/35780170/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
35078986 | 10.1038/s41467-022-28137-7 | Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage | The first step in CRISPR-Cas9-mediated genome editing is the cleavage of target DNA sequences that are complementary to so-called spacer sequences in CRISPR guide RNAs (gRNAs). However, some DNA sequences are refractory to CRISPR-Cas9 cleavage, which is at least in part due to gRNA misfolding. To overcome this problem,... | Nat Commun | Nature communications | 2022 Jan 25 | 2,022 | [
"Riesenberg S",
"Helmbrecht N",
"Kanis P",
"Maricic T",
"Pääbo S"
] | Riesenberg S | Pääbo S | [
"CRISPR-Cas Systems",
"Cell Line",
"Gene Editing",
"Genome",
"Humans",
"Nucleic Acid Conformation",
"Oligonucleotides",
"RNA, Guide, CRISPR-Cas Systems"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 13 | 1 | 489 | pmc-id: PMC8789806; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/35078986/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
34985944 | 10.1126/sciadv.abm1148 | A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans | Glutathione reductase is a critical enzyme for preventing oxidative stress and maintaining a reduced intracellular environment. Almost all present-day humans carry an amino acid substitution (S232G) in this enzyme relative to apes and Neanderthals. We express the modern human and the ancestral enzymes and show that whe... | Sci Adv | Science advances | 2022 Jan 7 | 2,022 | [
"Coppo L",
"Mishra P",
"Siefert N",
"Holmgren A",
"Pääbo S",
"Zeberg H"
] | Coppo L | Zeberg H | [] | [
"Journal Article"
] | 8 | 1 | eabm1148 | pmc-id: PMC8730399; | 2375-2548 | eng | https://pubmed.ncbi.nlm.nih.gov/34985944/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
34969841 | 10.1073/pnas.2113666118 | Microstratigraphic preservation of ancient faunal and hominin DNA in Pleistocene cave sediments | Ancient DNA recovered from Pleistocene sediments represents a rich resource for the study of past hominin and environmental diversity. However, little is known about how DNA is preserved in sediments and the extent to which it may be translocated between archaeological strata. Here, we investigate DNA preservation in 4... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2022 Jan 4 | 2,022 | [
"Massilani D",
"Morley MW",
"Mentzer SM",
"Aldeias V",
"Vernot B",
"Miller C",
"Stahlschmidt M",
"Kozlikin MB",
"Shunkov MV",
"Derevianko AP",
"Conard NJ",
"Wurz S",
"Henshilwood CS",
"Vasquez J",
"Essel E",
"Nagel S",
"Richter J",
"Nickel B",
"Roberts RG",
"Pääbo S",
"Slon V... | Massilani D | Meyer M | [
"Animals",
"Caves",
"DNA, Ancient",
"Fossils",
"Hominidae",
"Neanderthals"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 119 | 1 | null | pmc-id: PMC8740756; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/34969841/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
34824388 | 10.1038/s41559-021-01581-2 | The earliest Denisovans and their cultural adaptation | Since the initial identification of the Denisovans a decade ago, only a handful of their physical remains have been discovered. Here we analysed ~3,800 non-diagnostic bone fragments using collagen peptide mass fingerprinting to locate new hominin remains from Denisova Cave (Siberia, Russia). We identified five new homi... | Nat Ecol Evol | Nature ecology & evolution | 2022 Jan | 2,022 | [
"Brown S",
"Massilani D",
"Kozlikin MB",
"Shunkov MV",
"Derevianko AP",
"Stoessel A",
"Jope-Street B",
"Meyer M",
"Kelso J",
"Pääbo S",
"Higham T",
"Douka K"
] | Brown S | Douka K | [
"Animals",
"Archaeology",
"Caves",
"DNA, Mitochondrial",
"Hominidae",
"Neanderthals"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 6 | 1 | 28-35 | pmc-id: PMC7612221;manuscript-id: EMS135559; | 2397-334X | eng | https://pubmed.ncbi.nlm.nih.gov/34824388/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
34648345 | 10.1126/science.abi6060 | Comment on "Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment" | Trujillo et al. (Research Articles, 12 February 2021, eaax2537) conclude that the reintroduction of an ancestral amino acid substitution in the protein NOVA1 drastically alters the development of brain organoids. We show that cell lines used by the authors carry heterozygous deletions of the target DNA sequence, provid... | Science | Science (New York, N.Y.) | 2021 Oct 15 | 2,021 | [
"Maricic T",
"Helmbrecht N",
"Riesenberg S",
"Macak D",
"Kanis P",
"Lackner M",
"Pugach-Matveeva AD",
"Pääbo S"
] | Maricic T | Pääbo S | [
"Organoids"
] | [
"Journal Article",
"Comment"
] | 374 | 6565 | eabi6060 | null | 0036-8075 | eng | https://pubmed.ncbi.nlm.nih.gov/34648345/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
34163072 | 10.1038/s41586-021-03675-0 | Pleistocene sediment DNA reveals hominin and faunal turnovers at Denisova Cave | Denisova Cave in southern Siberia is the type locality of the Denisovans, an archaic hominin group who were related to Neanderthals1-4. The dozen hominin remains recovered from the deposits also include Neanderthals5,6 and the child of a Neanderthal and a Denisovan7, which suggests that Denisova Cave was a contact zone... | Nature | Nature | 2021 Jul | 2,021 | [
"Zavala EI",
"Jacobs Z",
"Vernot B",
"Shunkov MV",
"Kozlikin MB",
"Derevianko AP",
"Essel E",
"de Fillipo C",
"Nagel S",
"Richter J",
"Romagné F",
"Schmidt A",
"Li B",
"O'Gorman K",
"Slon V",
"Kelso J",
"Pääbo S",
"Roberts RG",
"Meyer M"
] | Zavala EI | Meyer M | [
"Animals",
"Archaeology",
"Caves",
"DNA, Ancient",
"DNA, Mitochondrial",
"Fossils",
"Geologic Sediments",
"History, Ancient",
"Hominidae",
"Neanderthals",
"Siberia"
] | [
"Historical Article",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 595 | 7867 | 399-403 | pmc-id: PMC8277575; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/34163072/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
33942714 | 10.7554/eLife.58741 | Reduced purine biosynthesis in humans after their divergence from Neandertals | We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than in the other primates, metabolites downstream of adenylosuccinate lyase, which cat... | Elife | eLife | 2021 May 4 | 2,021 | [
"Stepanova V",
"Moczulska KE",
"Vacano GN",
"Kurochkin I",
"Ju X",
"Riesenberg S",
"Macak D",
"Maricic T",
"Dombrowski L",
"Schörnig M",
"Anastassiadis K",
"Baker O",
"Naumann R",
"Khrameeva E",
"Vanushkina A",
"Stekolshchikova E",
"Egorova A",
"Tkachev A",
"Mazzarino R",
"Duva... | Stepanova V | Pääbo S | [
"Animals",
"Biosynthetic Pathways",
"Female",
"Gene Editing",
"Humans",
"Macaca",
"Male",
"Metabolome",
"Mice",
"Mice, Transgenic",
"Mutation, Missense",
"Neanderthals",
"Pan troglodytes",
"Purines"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 10 | null | null | pmc-id: PMC8133780; | 2050-084X | eng | https://pubmed.ncbi.nlm.nih.gov/33942714/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
33828320 | 10.1038/s41586-021-03335-3 | Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry | Modern humans appeared in Europe by at least 45,000 years ago1-5, but the extent of their interactions with Neanderthals, who disappeared by about 40,000 years ago6, and their relationship to the broader expansion of modern humans outside Africa are poorly understood. Here we present genome-wide data from three individ... | Nature | Nature | 2021 Apr | 2,021 | [
"Hajdinjak M",
"Mafessoni F",
"Skov L",
"Vernot B",
"Hübner A",
"Fu Q",
"Essel E",
"Nagel S",
"Nickel B",
"Richter J",
"Moldovan OT",
"Constantin S",
"Endarova E",
"Zahariev N",
"Spasov R",
"Welker F",
"Smith GM",
"Sinet-Mathiot V",
"Paskulin L",
"Fewlass H",
"Talamo S",
"R... | Hajdinjak M | Pääbo S | [
"Alleles",
"Americas",
"Animals",
"Archaeology",
"Bulgaria",
"Caves",
"DNA, Ancient",
"Asia, Eastern",
"Female",
"Genome, Human",
"History, Ancient",
"Humans",
"Male",
"Neanderthals",
"Phylogeny"
] | [
"Historical Article",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 592 | 7853 | 253-257 | pmc-id: PMC8026394;manuscript-id: EMS115988; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/33828320/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
33674580 | 10.1038/s41467-021-21627-0 | Point-of-care bulk testing for SARS-CoV-2 by combining hybridization capture with improved colorimetric LAMP | Efforts to contain the spread of SARS-CoV-2 have spurred the need for reliable, rapid, and cost-effective diagnostic methods which can be applied to large numbers of people. However, current standard protocols for the detection of viral nucleic acids while sensitive, require a high level of automation and sophisticated... | Nat Commun | Nature communications | 2021 Mar 5 | 2,021 | [
"Bokelmann L",
"Nickel O",
"Maricic T",
"Pääbo S",
"Meyer M",
"Borte S",
"Riesenberg S"
] | Bokelmann L | Riesenberg S | [
"COVID-19",
"COVID-19 Testing",
"Colorimetry",
"Coronavirus Nucleocapsid Proteins",
"Humans",
"Molecular Diagnostic Techniques",
"Nucleic Acid Amplification Techniques",
"Nucleic Acid Hybridization",
"Phosphoproteins",
"Point-of-Care Testing",
"RNA, Viral",
"SARS-CoV-2",
"Sensitivity and Spe... | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 12 | 1 | 1467 | pmc-id: PMC7935920; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/33674580/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
33593941 | 10.1073/pnas.2026309118 | A genomic region associated with protection against severe COVID-19 is inherited from Neandertals | It was recently shown that the major genetic risk factor associated with becoming severely ill with COVID-19 when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is inherited from Neandertals. New, larger genetic association studies now allow additional genetic risk factors to be discovered. Us... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2021 Mar 2 | 2,021 | [
"Zeberg H",
"Pääbo S"
] | Zeberg H | Pääbo S | [
"Animals",
"COVID-19",
"Chromosomes, Human, Pair 12",
"Evolution, Molecular",
"Genetic Predisposition to Disease",
"Haplotypes",
"Humans",
"Neanderthals",
"Quantitative Trait Loci"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 118 | 9 | null | pmc-id: PMC7936282; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/33593941/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
33382830 | 10.1371/journal.pone.0244824 | A direct RT-qPCR approach to test large numbers of individuals for SARS-CoV-2 | SARS-CoV-2 causes substantial morbidity and mortality in elderly and immunocompromised individuals, particularly in retirement homes, where transmission from asymptomatic staff and visitors may introduce the infection. Here we present a cheap and fast screening method based on direct RT-qPCR to detect SARS-CoV-2 in sin... | PLoS One | PloS one | 2020 | 2,020 | [
"Maricic T",
"Nickel O",
"Aximu-Petri A",
"Essel E",
"Gansauge M",
"Kanis P",
"Macak D",
"Richter J",
"Riesenberg S",
"Bokelmann L",
"Zeberg H",
"Meyer M",
"Borte S",
"Pääbo S"
] | Maricic T | Pääbo S | [
"COVID-19",
"COVID-19 Nucleic Acid Testing",
"Humans",
"Mass Screening",
"Real-Time Polymerase Chain Reaction",
"SARS-CoV-2"
] | [
"Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 15 | 12 | e0244824 | pmc-id: PMC7774962; | 1932-6203 | eng | https://pubmed.ncbi.nlm.nih.gov/33382830/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
33122381 | 10.1126/science.abb6320 | Denisovan DNA in Late Pleistocene sediments from Baishiya Karst Cave on the Tibetan Plateau | A late Middle Pleistocene mandible from Baishiya Karst Cave (BKC) on the Tibetan Plateau has been inferred to be from a Denisovan, an Asian hominin related to Neanderthals, on the basis of an amino acid substitution in its collagen. Here we describe the stratigraphy, chronology, and mitochondrial DNA extracted from the... | Science | Science (New York, N.Y.) | 2020 Oct 30 | 2,020 | [
"Zhang D",
"Xia H",
"Chen F",
"Li B",
"Slon V",
"Cheng T",
"Yang R",
"Jacobs Z",
"Dai Q",
"Massilani D",
"Shen X",
"Wang J",
"Feng X",
"Cao P",
"Yang MA",
"Yao J",
"Yang J",
"Madsen DB",
"Han Y",
"Ping W",
"Liu F",
"Perreault C",
"Chen X",
"Meyer M",
"Kelso J",
"Pää... | Zhang D | Fu Q | [
"Animals",
"Caves",
"DNA, Ancient",
"DNA, Mitochondrial",
"Geologic Sediments",
"Hominidae",
"Humans",
"Phylogeny",
"Tibet"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 370 | 6516 | 584-587 | null | 0036-8075 | eng | https://pubmed.ncbi.nlm.nih.gov/33122381/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
33122380 | 10.1126/science.abc1166 | Denisovan ancestry and population history of early East Asians | We present analyses of the genome of a ~34,000-year-old hominin skull cap discovered in the Salkhit Valley in northeastern Mongolia. We show that this individual was a female member of a modern human population that, following the split between East and West Eurasians, experienced substantial gene flow from West Eurasi... | Science | Science (New York, N.Y.) | 2020 Oct 30 | 2,020 | [
"Massilani D",
"Skov L",
"Hajdinjak M",
"Gunchinsuren B",
"Tseveendorj D",
"Yi S",
"Lee J",
"Nagel S",
"Nickel B",
"Devièse T",
"Higham T",
"Meyer M",
"Kelso J",
"Peter BM",
"Pääbo S"
] | Massilani D | Pääbo S | [
"Animals",
"Asian People",
"DNA, Ancient",
"Evolution, Molecular",
"Female",
"Hominidae",
"Humans",
"Mongolia",
"Population",
"Skull"
] | [
"Journal Article"
] | 370 | 6516 | 579-583 | null | 0036-8075 | eng | https://pubmed.ncbi.nlm.nih.gov/33122380/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
32998156 | 10.1038/s41586-020-2818-3 | The major genetic risk factor for severe COVID-19 is inherited from Neanderthals | A recent genetic association study1 identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)2 comprising 3,199 hospitalized patients with coronavirus disease 2... | Nature | Nature | 2020 Nov | 2,020 | [
"Zeberg H",
"Pääbo S"
] | Zeberg H | Pääbo S | [
"Animals",
"Asia",
"COVID-19",
"Case-Control Studies",
"Chromosomes, Human, Pair 3",
"Europe",
"Genetic Predisposition to Disease",
"Genetic Variation",
"Genome-Wide Association Study",
"Haplotypes",
"Hospitalization",
"Humans",
"Linkage Disequilibrium",
"Multigene Family",
"Neanderthals... | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 587 | 7835 | 610-612 | null | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/32998156/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
32707058 | 10.1016/j.cub.2020.06.045 | A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans | The sodium channel Nav1.7 is crucial for impulse generation and conduction in peripheral pain pathways [1]. In Neanderthals, the Nav1.7 protein carried three amino acid substitutions (M932L, V991L, and D1908G) relative to modern humans. We expressed Nav1.7 proteins carrying all combinations of these substitutions and s... | Curr Biol | Current biology : CB | 2020 Sep 7 | 2,020 | [
"Zeberg H",
"Dannemann M",
"Sahlholm K",
"Tsuo K",
"Maricic T",
"Wiebe V",
"Hevers W",
"Robinson HPC",
"Kelso J",
"Pääbo S"
] | Zeberg H | Pääbo S | [
"Adult",
"Aged",
"Amino Acid Substitution",
"Animals",
"Female",
"Humans",
"Male",
"Middle Aged",
"Mutation",
"NAV1.7 Voltage-Gated Sodium Channel",
"Neanderthals",
"Pain",
"Xenopus laevis"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 30 | 17 | 3465-3469.e4 | null | 0960-9822 | eng | https://pubmed.ncbi.nlm.nih.gov/32707058/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
32559457 | 10.1016/j.stemcr.2020.05.018 | Human Stem Cell Resources Are an Inroad to Neandertal DNA Functions | Induced pluripotent stem cells (iPSCs) from diverse humans offer the potential to study human functional variation in controlled culture environments. A portion of this variation originates from an ancient admixture between modern humans and Neandertals, which introduced alleles that left a phenotypic legacy on individ... | Stem Cell Reports | Stem cell reports | 2020 Jul 14 | 2,020 | [
"Dannemann M",
"He Z",
"Heide C",
"Vernot B",
"Sidow L",
"Kanton S",
"Weigert A",
"Treutlein B",
"Pääbo S",
"Kelso J",
"Camp JG"
] | Dannemann M | Camp JG | [
"Alleles",
"Animals",
"Brain",
"Cell Line",
"DNA",
"Haplotypes",
"Humans",
"Neanderthals",
"Phenotype",
"Pluripotent Stem Cells",
"RNA",
"Stem Cells"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 15 | 1 | 214-225 | pmc-id: PMC7363959; | 2213-6711 | eng | https://pubmed.ncbi.nlm.nih.gov/32559457/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
32546518 | 10.1073/pnas.2004944117 | A high-coverage Neandertal genome from Chagyrskaya Cave | We sequenced the genome of a Neandertal from Chagyrskaya Cave in the Altai Mountains, Russia, to 27-fold genomic coverage. We show that this Neandertal was a female and that she was more related to Neandertals in western Eurasia [Prüfer et al., Science 358, 655-658 (2017); Hajdinjak et al., Nature 555, 652-656 (2018)] ... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2020 Jun 30 | 2,020 | [
"Mafessoni F",
"Grote S",
"de Filippo C",
"Slon V",
"Kolobova KA",
"Viola B",
"Markin SV",
"Chintalapati M",
"Peyrégne S",
"Skov L",
"Skoglund P",
"Krivoshapkin AI",
"Derevianko AP",
"Meyer M",
"Kelso J",
"Peter B",
"Prüfer K",
"Pääbo S"
] | Mafessoni F | Pääbo S | [
"Animals",
"Biological Evolution",
"Female",
"Fossils",
"Gene Expression Regulation",
"Genetic Variation",
"Genome",
"Humans",
"Inbreeding",
"Neanderthals",
"Population Density",
"Russia"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 117 | 26 | 15132-15136 | pmc-id: PMC7334501; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/32546518/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
32437543 | 10.1093/molbev/msaa119 | The Neandertal Progesterone Receptor | The hormone progesterone is important for preparing the uterine lining for egg implantation and for maintaining the early stages of pregnancy. The gene encoding the progesterone receptor (PGR) carries introgressed Neandertal haplotypes with two missense substitutions and a mobile Alu element. These Neandertal gene vari... | Mol Biol Evol | Molecular biology and evolution | 2020 Sep 1 | 2,020 | [
"Zeberg H",
"Kelso J",
"Pääbo S"
] | Zeberg H | Pääbo S | [
"Alleles",
"Alu Elements",
"Animals",
"Female",
"Fertility",
"Genetic Introgression",
"Haplotypes",
"Humans",
"Neanderthals",
"Pregnancy",
"Premature Birth",
"Receptors, Progesterone"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 37 | 9 | 2655-2660 | pmc-id: PMC7475037; | 0737-4038 | eng | https://pubmed.ncbi.nlm.nih.gov/32437543/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
32433609 | 10.1038/s41586-020-2259-z | Initial Upper Palaeolithic Homo sapiens from Bacho Kiro Cave, Bulgaria | The Middle to Upper Palaeolithic transition in Europe witnessed the replacement and partial absorption of local Neanderthal populations by Homo sapiens populations of African origin1. However, this process probably varied across regions and its details remain largely unknown. In particular, the duration of chronologica... | Nature | Nature | 2020 May | 2,020 | [
"Hublin JJ",
"Sirakov N",
"Aldeias V",
"Bailey S",
"Bard E",
"Delvigne V",
"Endarova E",
"Fagault Y",
"Fewlass H",
"Hajdinjak M",
"Kromer B",
"Krumov I",
"Marreiros J",
"Martisius NL",
"Paskulin L",
"Sinet-Mathiot V",
"Meyer M",
"Pääbo S",
"Popov V",
"Rezek Z",
"Sirakova S",
... | Hublin JJ | Tsanova T | [
"Animals",
"Asia",
"Bone and Bones",
"Bulgaria",
"Caves",
"DNA, Ancient",
"DNA, Mitochondrial",
"Europe",
"Fossils",
"History, Ancient",
"Human Migration",
"Humans",
"Neanderthals",
"Phylogeny",
"Tool Use Behavior",
"Tooth"
] | [
"Historical Article",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 581 | 7808 | 299-302 | null | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/32433609/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
32424074 | 10.1101/gr.256958.119 | Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains | Identification of gene expression traits unique to the human brain sheds light on the molecular mechanisms underlying human evolution. Here, we searched for uniquely human gene expression traits by analyzing 422 brain samples from humans, chimpanzees, bonobos, and macaques representing 33 anatomical regions, as well as... | Genome Res | Genome research | 2020 May | 2,020 | [
"Khrameeva E",
"Kurochkin I",
"Han D",
"Guijarro P",
"Kanton S",
"Santel M",
"Qian Z",
"Rong S",
"Mazin P",
"Sabirov M",
"Bulat M",
"Efimova O",
"Tkachev A",
"Guo S",
"Sherwood CC",
"Camp JG",
"Pääbo S",
"Treutlein B",
"Khaitovich P"
] | Khrameeva E | Khaitovich P | [
"Animals",
"Brain",
"Evolution, Molecular",
"Humans",
"Immunohistochemistry",
"Macaca",
"Neurons",
"Pan paniscus",
"Pan troglodytes",
"RNA-Seq",
"Single-Cell Analysis",
"Transcriptome"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 30 | 5 | 776-789 | pmc-id: PMC7263190; | 1088-9051 | eng | https://pubmed.ncbi.nlm.nih.gov/32424074/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
31619793 | 10.1038/s41586-019-1654-9 | Organoid single-cell genomic atlas uncovers human-specific features of brain development | The human brain has undergone substantial change since humans diverged from chimpanzees and the other great apes1,2. However, the genetic and developmental programs that underlie this divergence are not fully understood. Here we have analysed stem cell-derived cerebral organoids using single-cell transcriptomics and ac... | Nature | Nature | 2019 Oct | 2,019 | [
"Kanton S",
"Boyle MJ",
"He Z",
"Santel M",
"Weigert A",
"Sanchís-Calleja F",
"Guijarro P",
"Sidow L",
"Fleck JS",
"Han D",
"Qian Z",
"Heide M",
"Huttner WB",
"Khaitovich P",
"Pääbo S",
"Treutlein B",
"Camp JG"
] | Kanton S | Camp JG | [
"Animals",
"Biological Evolution",
"Brain",
"Genomics",
"Humans",
"Macaca",
"Organoids",
"Pan troglodytes",
"Pluripotent Stem Cells",
"Single-Cell Analysis",
"Species Specificity"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 574 | 7778 | 418-422 | null | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/31619793/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
31392986 | 10.1093/nar/gkz669 | Simultaneous precise editing of multiple genes in human cells | When double-strand breaks are introduced in a genome by CRISPR they are repaired either by non-homologous end joining (NHEJ), which often results in insertions or deletions (indels), or by homology-directed repair (HDR), which allows precise nucleotide substitutions to be introduced if a donor oligonucleotide is provid... | Nucleic Acids Res | Nucleic acids research | 2019 Nov 4 | 2,019 | [
"Riesenberg S",
"Chintalapati M",
"Macak D",
"Kanis P",
"Maricic T",
"Pääbo S"
] | Riesenberg S | Pääbo S | [
"CRISPR-Cas Systems",
"Chromosomes",
"DNA Breaks, Double-Stranded",
"DNA End-Joining Repair",
"DNA-Activated Protein Kinase",
"Gene Editing",
"HEK293 Cells",
"Humans",
"INDEL Mutation",
"Oligonucleotides",
"Recombinational DNA Repair",
"Sequence Deletion"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 47 | 19 | e116 | pmc-id: PMC6821318; | 0305-1048 | eng | https://pubmed.ncbi.nlm.nih.gov/31392986/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
31308224 | 10.1073/pnas.1903984116 | A genetic analysis of the Gibraltar Neanderthals | The Forbes' Quarry and Devil's Tower partial crania from Gibraltar are among the first Neanderthal remains ever found. Here, we show that small amounts of ancient DNA are preserved in the petrous bones of the 2 individuals despite unfavorable climatic conditions. However, the endogenous Neanderthal DNA is present among... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2019 Jul 30 | 2,019 | [
"Bokelmann L",
"Hajdinjak M",
"Peyrégne S",
"Brace S",
"Essel E",
"de Filippo C",
"Glocke I",
"Grote S",
"Mafessoni F",
"Nagel S",
"Kelso J",
"Prüfer K",
"Vernot B",
"Barnes I",
"Pääbo S",
"Meyer M",
"Stringer C"
] | Bokelmann L | Stringer C | [
"Animals",
"DNA, Ancient",
"Gibraltar",
"History, Ancient",
"Humans",
"Neanderthals",
"Oligonucleotide Array Sequence Analysis"
] | [
"Historical Article",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 116 | 31 | 15610-15615 | pmc-id: PMC6681707; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/31308224/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
31249872 | 10.1126/sciadv.aaw5873 | Nuclear DNA from two early Neandertals reveals 80,000 years of genetic continuity in Europe | Little is known about the population history of Neandertals over the hundreds of thousands of years of their existence. We retrieved nuclear genomic sequences from two Neandertals, one from Hohlenstein-Stadel Cave in Germany and the other from Scladina Cave in Belgium, who lived around 120,000 years ago. Despite the de... | Sci Adv | Science advances | 2019 Jun | 2,019 | [
"Peyrégne S",
"Slon V",
"Mafessoni F",
"de Filippo C",
"Hajdinjak M",
"Nagel S",
"Nickel B",
"Essel E",
"Le Cabec A",
"Wehrberger K",
"Conard NJ",
"Kind CJ",
"Posth C",
"Krause J",
"Abrams G",
"Bonjean D",
"Di Modica K",
"Toussaint M",
"Kelso J",
"Meyer M",
"Pääbo S",
"Prüf... | Peyrégne S | Prüfer K | [
"Animals",
"Cell Lineage",
"Cell Nucleus",
"DNA",
"Europe",
"Evolution, Molecular",
"Fossils",
"Genome",
"Germany",
"Mitochondria",
"Neanderthals"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 5 | 6 | eaaw5873 | pmc-id: PMC6594762; | 2375-2548 | eng | https://pubmed.ncbi.nlm.nih.gov/31249872/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
31043659 | 10.1038/s41598-019-43122-9 | Publisher Correction: Lipidome determinants of maximal lifespan in mammals | A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. | Sci Rep | Scientific reports | 2019 May 1 | 2,019 | [
"Bozek K",
"Khrameeva EE",
"Reznick J",
"Omerbašić D",
"Bennett NC",
"Lewin GR",
"Azpurua J",
"Gorbunova V",
"Seluanov A",
"Regnard P",
"Wanert F",
"Marchal J",
"Pifferi F",
"Aujard F",
"Liu Z",
"Shi P",
"Pääbo S",
"Schroeder F",
"Willmitzer L",
"Giavalisco P",
"Khaitovich P"... | Bozek K | Khaitovich P | [] | [
"Published Erratum"
] | 9 | 1 | 6972 | pmc-id: PMC6494842; | 2045-2322 | eng | https://pubmed.ncbi.nlm.nih.gov/31043659/ | Gj7rM7G98R1iiN4a9 | xN2RmkUBFZvNFdkT8 |
41509466 | 10.64898/2025.12.24.696419 | Macrophage-Dendritic Cell-T-Cell Tetrads Orchestrate Antitumor Immunity and Response to Checkpoint Blockade | Immune checkpoint inhibitors (ICIs) elicit durable responses in only a subset of patients with solid tumors, underscoring the need to define the cellular architectures that govern effective antitumor immunity. Here we identify a spatially organized multicellular immune unit comprising macrophages, cDC1s, CD4+ T-cells, ... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Dec 29 | 2,025 | [
"Chaib M",
"Aminu M",
"Herbrich S",
"Arabi M",
"Xuan Y",
"Basi A",
"Casasent A",
"Macaluso MD",
"Hu KH",
"Gubin M",
"Chen X",
"Mancuso JJ",
"Basu S",
"Jindal S",
"Burks J",
"Watowich S",
"Wu J",
"Allison JP",
"Sharma P"
] | Chaib M | Sharma P | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12776307; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41509466/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
41327972 | 10.1158/2159-8290.CD-25-1639 | Editor's Note: Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade | null | Cancer Discov | Cancer discovery | 2025 Dec 2 | 2,025 | [
"Chen PL",
"Roh W",
"Reuben A",
"Cooper ZA",
"Spencer CN",
"Prieto PA",
"Miller JP",
"Bassett RL",
"Gopalakrishnan V",
"Wani K",
"De Macedo MP",
"Austin-Breneman JL",
"Jiang H",
"Chang Q",
"Reddy SM",
"Chen WS",
"Tetzlaff MT",
"Broaddus RJ",
"Davies MA",
"Gershenwald JE",
"Ha... | Chen PL | Wargo JA | [] | [
"Journal Article",
"Expression of Concern"
] | 15 | 12 | 2574 | null | 2159-8274 | eng | https://pubmed.ncbi.nlm.nih.gov/41327972/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
41298974 | 10.1038/s41577-025-01253-3 | Local T(reg) cell loss reprogrammes systemic antitumour immunity without breaking tolerance | null | Nat Rev Immunol | Nature reviews. Immunology | 2026 Jan | 2,026 | [
"Chaib M",
"Allison JP"
] | Chaib M | Allison JP | [] | [
"Journal Article"
] | 26 | 1 | 5 | null | 1474-1733 | eng | https://pubmed.ncbi.nlm.nih.gov/41298974/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
40836096 | 10.1038/s41586-025-09370-8 | Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy | Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types1, yet its mechanism remains unclear. Here we provide clinical and mechanistic insights into the role of PNI and cancer-induced nerve injury (CINI) in resistance to anti-PD-1 therapy. Our study demonstrates that PNI and CIN... | Nature | Nature | 2025 Oct | 2,025 | [
"Baruch EN",
"Gleber-Netto FO",
"Nagarajan P",
"Rao X",
"Akhter S",
"Eichwald T",
"Xie T",
"Balood M",
"Adewale A",
"Naara S",
"Sathishkumar HN",
"Islam S",
"McCarthy W",
"Mattson BJ",
"Ferrarotto R",
"Wong MK",
"Davies MA",
"Jindal S",
"Basu S",
"Roversi K",
"Nikpoor AR",
... | Baruch EN | Amit M | [
"Animals",
"Programmed Cell Death 1 Receptor",
"Mice",
"Humans",
"Drug Resistance, Neoplasm",
"Female",
"Male",
"Interleukin-6",
"Melanoma",
"Interferon Type I",
"Tumor Microenvironment",
"Receptor, Interferon alpha-beta",
"Stomach Neoplasms",
"Skin Neoplasms",
"Peripheral Nerve Injuries... | [
"Journal Article",
"Research Support, N.I.H., Extramural"
] | 646 | 8084 | 462-473 | pmc-id: PMC12406299;manuscript-id: NIHMS2102231; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/40836096/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
40596685 | 10.1038/s41577-025-01204-y | Tumour cells mimic erythroblasts to hijack iron from bone marrow macrophages | null | Nat Rev Immunol | Nature reviews. Immunology | 2025 Aug | 2,025 | [
"Chaib M",
"Allison JP"
] | Chaib M | Allison JP | [] | [
"Journal Article"
] | 25 | 8 | 557 | null | 1474-1733 | eng | https://pubmed.ncbi.nlm.nih.gov/40596685/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
40044812 | 10.1038/s41577-025-01157-2 | Neutrophils are dispensable for Shigella control: macrophages take centre stage | null | Nat Rev Immunol | Nature reviews. Immunology | 2025 Apr | 2,025 | [
"Ağaç Çobanoğlu D",
"Allison JP"
] | Ağaç Çobanoğlu D | Allison JP | [] | [
"Journal Article"
] | 25 | 4 | 233 | null | 1474-1733 | eng | https://pubmed.ncbi.nlm.nih.gov/40044812/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
39786926 | 10.1073/pnas.2418985122 | Anti-CTLA-4 generates greater memory response than anti-PD-1 via TCF-1 | The effects of T cell differentiation arising from immune checkpoint inhibition targeting cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1) on the immunological memory response remain unclear. Our investigation into the effects of anti-CTLA-4 and anti-PD-1 on memory T cell ... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2025 Jan 14 | 2,025 | [
"Mok S",
"Liu H",
"Ağaç Çobanoğlu D",
"Anang NAS",
"Mancuso JJ",
"Wherry EJ",
"Allison JP"
] | Mok S | Allison JP | [
"Animals",
"Mice",
"Immunologic Memory",
"CTLA-4 Antigen",
"Programmed Cell Death 1 Receptor",
"Mice, Knockout",
"Hepatocyte Nuclear Factor 1-alpha",
"Immune Checkpoint Inhibitors",
"Memory T Cells",
"Mice, Inbred C57BL"
] | [
"Journal Article"
] | 122 | 2 | e2418985122 | pmc-id: PMC11745370; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/39786926/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
39048822 | 10.1038/s41586-024-07752-y | Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy | CD4+ T cells can either enhance or inhibit tumour immunity. Although regulatory T cells have long been known to impede antitumour responses1-5, other CD4+ T cells have recently been implicated in inhibiting this response6,7. Yet, the nature and function of the latter remain unclear. Here, using vaccines containing MHC ... | Nature | Nature | 2024 Aug | 2,024 | [
"Sultan H",
"Takeuchi Y",
"Ward JP",
"Sharma N",
"Liu TT",
"Sukhov V",
"Firulyova M",
"Song Y",
"Ameh S",
"Brioschi S",
"Khantakova D",
"Arthur CD",
"White JM",
"Kohlmiller H",
"Salazar AM",
"Burns R",
"Costa HA",
"Moynihan KD",
"Yeung YA",
"Djuretic I",
"Schumacher TN",
"S... | Sultan H | Schreiber RD | [
"Animals",
"Female",
"Humans",
"Male",
"Mice",
"Antigens, Neoplasm",
"Cancer Vaccines",
"CD4-Positive T-Lymphocytes",
"Cell Line, Tumor",
"Chemokine CCL5",
"Dendritic Cells",
"Granzymes",
"Histocompatibility Antigens Class I",
"Histocompatibility Antigens Class II",
"Immunotherapy",
"I... | [
"Journal Article",
"Research Support, N.I.H., Intramural"
] | 632 | 8023 | 182-191 | pmc-id: PMC11291290; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/39048822/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
38923991 | 10.1073/pnas.2404661121 | Post-immunotherapy CTLA-4 Ig treatment improves antitumor efficacy | Immune checkpoint therapies (ICT) improve overall survival of patients with cancer but may cause immune-related adverse events (irAEs) such as myocarditis. Cytotoxic T lymphocyte-associated antigen 4 immunoglobulin fusion protein (CTLA-4 Ig), an inhibitor of T cell costimulation through CD28, reverses irAEs in animal m... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2024 Jul 2 | 2,024 | [
"Mok S",
"Ağaç Çobanoğlu D",
"Liu H",
"Mancuso JJ",
"Allison JP"
] | Mok S | Allison JP | [
"Animals",
"Mice",
"Immunotherapy",
"CTLA-4 Antigen",
"Immune Checkpoint Inhibitors",
"CD8-Positive T-Lymphocytes",
"T-Lymphocytes, Regulatory",
"Cell Line, Tumor",
"Abatacept",
"Female",
"Humans",
"Mice, Inbred C57BL",
"Neoplasms",
"Programmed Cell Death 1 Receptor"
] | [
"Journal Article"
] | 121 | 27 | e2404661121 | pmc-id: PMC11228532; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/38923991/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
38842383 | 10.1158/2326-6066.CIR-23-0527 | Pancreatic Epithelial IL17/IL17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis | IL17 is required for the initiation and progression of pancreatic cancer, particularly in the context of inflammation, as previously shown by genetic and pharmacological approaches. However, the cellular compartment and downstream molecular mediators of IL17-mediated pancreatic tumorigenesis have not been fully identif... | Cancer Immunol Res | Cancer immunology research | 2024 Sep 3 | 2,024 | [
"Castro-Pando S",
"Howell RM",
"Li L",
"Mascaro M",
"Faraoni EY",
"Le Roux O",
"Romanin D",
"Tahan V",
"Riquelme E",
"Zhang Y",
"Kolls JK",
"Allison JP",
"Lozano G",
"Moghaddam SJ",
"McAllister F"
] | Castro-Pando S | McAllister F | [
"Animals",
"Interleukin-17",
"Pancreatic Neoplasms",
"Receptors, Interleukin-17",
"Mice",
"Signal Transduction",
"V-Set Domain-Containing T-Cell Activation Inhibitor 1",
"Tumor Microenvironment",
"Carcinogenesis",
"Mice, Transgenic",
"Humans",
"Epithelial Cells",
"Mice, Knockout",
"Gene Ex... | [
"Journal Article"
] | 12 | 9 | 1170-1183 | pmc-id: PMC11369627; | 2326-6066 | eng | https://pubmed.ncbi.nlm.nih.gov/38842383/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
38768394 | 10.1158/2326-6066.CIR-24-0011 | Molecular Pathways and Cellular Subsets Associated with Adverse Clinical Outcomes in Overlapping Immune-Related Myocarditis and Myositis | Immune checkpoint therapies (ICT) can induce life-threatening immune-related adverse events, including myocarditis and myositis, which are rare but often concurrent. The molecular pathways and immune subsets underlying these toxicities remain poorly understood. To address this need, we performed single-cell RNA sequenc... | Cancer Immunol Res | Cancer immunology research | 2024 Aug 1 | 2,024 | [
"Siddiqui BA",
"Palaskas NL",
"Basu S",
"Dai Y",
"He Z",
"Yadav SS",
"Allison JP",
"Sheth RA",
"Tummala S",
"Buja M",
"Bhattacharjee MB",
"Iliescu C",
"Rawther-Karedath A",
"Deswal A",
"Wang L",
"Sharma P",
"Subudhi SK"
] | Siddiqui BA | Subudhi SK | [
"Humans",
"Myocarditis",
"Myositis",
"Male",
"Female",
"Middle Aged",
"Immune Checkpoint Inhibitors",
"Aged",
"Neoplasms",
"CD8-Positive T-Lymphocytes",
"Adult",
"Receptors, IgG",
"Muscle, Skeletal",
"Single-Cell Analysis"
] | [
"Journal Article"
] | 12 | 8 | 964-987 | pmc-id: PMC12302522;manuscript-id: NIHMS2096247; | 2326-6066 | eng | https://pubmed.ncbi.nlm.nih.gov/38768394/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
38683200 | 10.1158/1078-0432.CCR-23-3740 | A Modular Trial of Androgen Signaling Inhibitor Combinations Testing a Risk-Adapted Strategy in Patients with Metastatic Castration-Resistant Prostate Cancer | To determine the efficacy and safety of risk-adapted combinations of androgen signaling inhibitors and inform disease classifiers for metastatic castration-resistant prostate cancers. In a modular, randomized phase II trial, 192 men were treated with 8 weeks of abiraterone acetate, prednisone, and apalutamide (AAPA; mo... | Clin Cancer Res | Clinical cancer research : an official journal of the American Association for Cancer Research | 2024 Jul 1 | 2,024 | [
"Aparicio AM",
"Tidwell RSS",
"Yadav SS",
"Chen JS",
"Zhang M",
"Liu J",
"Guo S",
"Pilié PG",
"Yu Y",
"Song X",
"Vundavilli H",
"Jindal S",
"Zhu K",
"Viscuse PV",
"Lebenthal JM",
"Hahn AW",
"Soundararajan R",
"Corn PG",
"Zurita-Saavedra A",
"Subudhi SK",
"Zhang J",
"Wang W"... | Aparicio AM | Logothetis CJ | [
"Humans",
"Male",
"Prostatic Neoplasms, Castration-Resistant",
"Aged",
"Antineoplastic Combined Chemotherapy Protocols",
"Middle Aged",
"Prednisone",
"Abiraterone Acetate",
"Thiohydantoins",
"Aged, 80 and over",
"Androgen Antagonists",
"Carboplatin",
"Ipilimumab",
"Taxoids"
] | [
"Journal Article",
"Randomized Controlled Trial",
"Clinical Trial, Phase II"
] | 30 | 13 | 2751-2763 | pmc-id: PMC11216872;manuscript-id: NIHMS1990885; | 1078-0432 | eng | https://pubmed.ncbi.nlm.nih.gov/38683200/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
38517331 | 10.1084/jem.20231263 | ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype | We have previously demonstrated synergy between ICOS costimulation (IVAX; ICOSL-transduced B16-F10 cellular vaccine) and CTLA-4 blockade in antitumor therapy. In this study, we employed CyTOF and single-cell RNA sequencing and observed significant remodeling of the lymphoid and myeloid compartments in combination thera... | J Exp Med | The Journal of experimental medicine | 2024 Apr 1 | 2,024 | [
"Sharma N",
"Fan X",
"Atolagbe OT",
"Ge Z",
"Dao KN",
"Sharma P",
"Allison JP"
] | Sharma N | Allison JP | [
"Humans",
"CTLA-4 Antigen",
"Tumor-Associated Macrophages",
"Neoplasms",
"CD8-Positive T-Lymphocytes",
"Phenotype",
"Tumor Microenvironment",
"Inducible T-Cell Co-Stimulator Protein"
] | [
"Journal Article"
] | 221 | 4 | null | pmc-id: PMC10959121; | 0022-1007 | eng | https://pubmed.ncbi.nlm.nih.gov/38517331/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
38169219 | 10.1016/j.ejca.2023.113501 | The future of targeting cytotoxic T-lymphocyte-associated protein-4: Is there a role? | The 2022 yearly Think Tank Meeting in Siena, Tuscany (Italy), organized by the Italian Network for Tumor Biotherapy (NIBIT) Foundation, the Parker Institute for Cancer Immunotherapy and the World Immunotherapy Council, included a focus on the future of integrating and expanding the use of targeting cytotoxic T-lymphocy... | Eur J Cancer | European journal of cancer (Oxford, England : 1990) | 2024 Feb | 2,024 | [
"Di Giacomo AM",
"Lahn M",
"Eggermont AM",
"Fox B",
"Ibrahim R",
"Sharma P",
"Allison JP",
"Maio M"
] | Di Giacomo AM | Maio M | [
"Humans",
"CTLA-4 Antigen",
"T-Lymphocytes, Cytotoxic",
"Neoplasms",
"Italy",
"Immunotherapy"
] | [
"Journal Article",
"Review"
] | 198 | null | 113501 | null | 0959-8049 | eng | https://pubmed.ncbi.nlm.nih.gov/38169219/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
37724990 | 10.1158/1078-0432.CCR-23-0088 | Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome | Lynch syndrome (LS) is a hereditary condition with a high lifetime risk of colorectal and endometrial cancers. Exercise is a non-pharmacologic intervention to reduce cancer risk, though its impact on patients with LS has not been prospectively studied. Here, we evaluated the impact of a 12-month aerobic exercise cyclin... | Clin Cancer Res | Clinical cancer research : an official journal of the American Association for Cancer Research | 2023 Nov 1 | 2,023 | [
"Deng N",
"Reyes-Uribe L",
"Fahrmann JF",
"Thoman WS",
"Munsell MF",
"Dennison JB",
"Murage E",
"Wu R",
"Hawk ET",
"Thirumurthi S",
"Lynch PM",
"Dieli-Conwright CM",
"Lazar AJ",
"Jindal S",
"Chu K",
"Chelvanambi M",
"Basen-Engquist K",
"Li Y",
"Wargo JA",
"McAllister F",
"All... | Deng N | Vilar E | [
"Female",
"Humans",
"Colorectal Neoplasms, Hereditary Nonpolyposis",
"Exercise",
"Endometrial Neoplasms",
"Gene Expression Profiling",
"Intestinal Mucosa"
] | [
"Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't",
"Research Support, N.I.H., Extramural"
] | 29 | 21 | 4361-4372 | pmc-id: PMC10618653;manuscript-id: NIHMS1930107; | 1078-0432 | eng | https://pubmed.ncbi.nlm.nih.gov/37724990/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
37702540 | 10.1158/2326-6066.CIR-23-0672 | Cancer Immunology and Immunotherapy Showcased in the AACR Cancer Progress Report 2023 | null | Cancer Immunol Res | Cancer immunology research | 2023 Oct 4 | 2,023 | [
"Sharma P",
"Allison JP"
] | Sharma P | Allison JP | [] | [
"Journal Article"
] | 11 | 10 | 1298-1299 | null | 2326-6066 | eng | https://pubmed.ncbi.nlm.nih.gov/37702540/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
37503252 | 10.21203/rs.3.rs-3161761/v1 | Inflammation induced by tumor-associated nerves promotes resistance to anti-PD-1 therapy in cancer patients and is targetable by interleukin-6 blockade | While the nervous system has reciprocal interactions with both cancer and the immune system, little is known about the potential role of tumor associated nerves (TANs) in modulating anti-tumoral immunity. Moreover, while peri-neural invasion is a well establish poor prognostic factor across cancer types, the mechanisms... | Res Sq | Research square | 2023 Jul 18 | 2,023 | [
"Baruch EN",
"Nagarajan P",
"Gleber-Netto FO",
"Rao X",
"Xie T",
"Akhter S",
"Adewale A",
"Shajedul I",
"Mattson BJ",
"Ferrarotto R",
"Wong MK",
"Davies MA",
"Jindal S",
"Basu S",
"Harwood C",
"Leigh I",
"Ajami N",
"Futreal A",
"Castillo M",
"Gunaratne P",
"Goepfert RP",
"K... | Baruch EN | Amit M | [] | [
"Preprint"
] | null | null | null | pmc-id: PMC10371163; | 2693-5015 | eng | https://pubmed.ncbi.nlm.nih.gov/37503252/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
37059068 | 10.1016/j.cell.2023.03.006 | Immune checkpoint therapy-current perspectives and future directions | Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer patients and conferred durable clinical benefits, including cure in a subset of patients. Varying response rates across tumor types and the need for predictive biomarkers to optimize patient selection to maximize efficacy and minimize... | Cell | Cell | 2023 Apr 13 | 2,023 | [
"Sharma P",
"Goswami S",
"Raychaudhuri D",
"Siddiqui BA",
"Singh P",
"Nagarajan A",
"Liu J",
"Subudhi SK",
"Poon C",
"Gant KL",
"Herbrich SM",
"Anandhan S",
"Islam S",
"Amit M",
"Anandappa G",
"Allison JP"
] | Sharma P | Allison JP | [
"Humans",
"B7-H1 Antigen",
"Immunotherapy",
"Neoplasms",
"Clinical Trials as Topic",
"Immune Checkpoint Inhibitors"
] | [
"Journal Article",
"Review",
"Research Support, Non-U.S. Gov't"
] | 186 | 8 | 1652-1669 | null | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/37059068/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
36928818 | 10.1038/s41591-022-02189-0 | Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial | Neoadjuvant ipilimumab + nivolumab (Ipi+Nivo) and nivolumab + chemotherapy (Nivo+CT) induce greater pathologic response rates than CT alone in patients with operable non-small cell lung cancer (NSCLC). The impact of adding ipilimumab to neoadjuvant Nivo+CT is unknown. Here we report the results and correlates of two ar... | Nat Med | Nature medicine | 2023 Mar | 2,023 | [
"Cascone T",
"Leung CH",
"Weissferdt A",
"Pataer A",
"Carter BW",
"Godoy MCB",
"Feldman H",
"William WN Jr",
"Xi Y",
"Basu S",
"Sun JJ",
"Yadav SS",
"Rojas Alvarez FR",
"Lee Y",
"Mishra AK",
"Chen L",
"Pradhan M",
"Guo H",
"Sinjab A",
"Zhou N",
"Negrao MV",
"Le X",
"Gay C... | Cascone T | Sepesi B | [
"Humans",
"Nivolumab",
"Ipilimumab",
"Carcinoma, Non-Small-Cell Lung",
"Neoadjuvant Therapy",
"Melanoma",
"Antineoplastic Combined Chemotherapy Protocols",
"Lung Neoplasms"
] | [
"Clinical Trial, Phase II",
"Journal Article",
"Research Support, Non-U.S. Gov't",
"Research Support, N.I.H., Extramural",
"Adaptive Clinical Trial"
] | 29 | 3 | 593-604 | pmc-id: PMC10033402; | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/36928818/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
36894629 | 10.1038/s41586-023-05892-1 | Author Correction: Neoadjuvant relatlimab and nivolumab in resectable melanoma | null | Nature | Nature | 2023 Mar | 2,023 | [
"Amaria RN",
"Postow M",
"Burton EM",
"Tetzlaff MT",
"Ross MI",
"Torres-Cabala C",
"Glitza IC",
"Duan F",
"Milton DR",
"Busam K",
"Simpson L",
"McQuade JL",
"Wong MK",
"Gershenwald JE",
"Lee JE",
"Goepfert RP",
"Keung EZ",
"Fisher SB",
"Betof-Warner A",
"Shoushtari AN",
"Call... | Amaria RN | Tawbi HA | [] | [
"Published Erratum"
] | 615 | 7953 | E23 | pmc-id: PMC10033416; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/36894629/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
36385524 | 10.1038/s41586-022-05432-3 | T cells specific for α-myosin drive immunotherapy-related myocarditis | Immune-related adverse events, particularly severe toxicities such as myocarditis, are major challenges to the utility of immune checkpoint inhibitors (ICIs) in anticancer therapy1. The pathogenesis of ICI-associated myocarditis (ICI-MC) is poorly understood. Pdcd1-/-Ctla4+/- mice recapitulate clinicopathological featu... | Nature | Nature | 2022 Nov | 2,022 | [
"Axelrod ML",
"Meijers WC",
"Screever EM",
"Qin J",
"Carroll MG",
"Sun X",
"Tannous E",
"Zhang Y",
"Sugiura A",
"Taylor BC",
"Hanna A",
"Zhang S",
"Amancherla K",
"Tai W",
"Wright JJ",
"Wei SC",
"Opalenik SR",
"Toren AL",
"Rathmell JC",
"Ferrell PB",
"Phillips EJ",
"Mallal ... | Axelrod ML | Balko JM | [
"Animals",
"Mice",
"Autoantigens",
"CD8-Positive T-Lymphocytes",
"CTLA-4 Antigen",
"Immunotherapy",
"Myocarditis",
"Ventricular Myosins",
"Programmed Cell Death 1 Receptor"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't",
"Research Support, N.I.H., Extramural"
] | 611 | 7937 | 818-826 | pmc-id: PMC9930174;manuscript-id: NIHMS1869777; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/36385524/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
36367776 | 10.1084/jem.20221333 | Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration | Immune checkpoint blockade (ICB) has revolutionized cancer treatment, yet quality of life and continuation of therapy can be constrained by immune-related adverse events (irAEs). Limited understanding of irAE mechanisms hampers development of approaches to mitigate their damage. To address this, we examined whether mic... | J Exp Med | The Journal of experimental medicine | 2023 Feb 6 | 2,023 | [
"Zhou Y",
"Medik YB",
"Patel B",
"Zamler DB",
"Chen S",
"Chapman T",
"Schneider S",
"Park EM",
"Babcock RL",
"Chrisikos TT",
"Kahn LM",
"Dyevoich AM",
"Pineda JE",
"Wong MC",
"Mishra AK",
"Cass SH",
"Cogdill AP",
"Johnson DH",
"Johnson SB",
"Wani K",
"Ledesma DA",
"Hudgens ... | Zhou Y | Watowich SS | [
"Mice",
"Animals",
"Interleukin-6",
"Quality of Life",
"Colitis",
"Immunotherapy",
"Inflammation"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural",
"Research Support, U.S. Gov't, Non-P.H.S.",
"Research Support, Non-U.S. Gov't"
] | 220 | 2 | null | pmc-id: PMC9664499; | 0022-1007 | eng | https://pubmed.ncbi.nlm.nih.gov/36367776/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
36350993 | 10.1126/scitranslmed.adf2947 | Immune checkpoint therapy: Forging ahead | Spatiotemporal immune monitoring in clinical trials and reverse translation will help to determine optimal combination immune therapies to cure cancer. | Sci Transl Med | Science translational medicine | 2022 Nov 9 | 2,022 | [
"Sharma P",
"Allison JP"
] | Sharma P | Allison JP | [
"Humans",
"Immunotherapy",
"Neoplasms",
"Combined Modality Therapy"
] | [
"Editorial"
] | 14 | 670 | eadf2947 | null | 1946-6234 | eng | https://pubmed.ncbi.nlm.nih.gov/36350993/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
36289334 | 10.1038/s41586-022-05368-8 | Neoadjuvant relatlimab and nivolumab in resectable melanoma | Relatlimab and nivolumab combination immunotherapy improves progression-free survival over nivolumab monotherapy in patients with unresectable advanced melanoma1. We investigated this regimen in patients with resectable clinical stage III or oligometastatic stage IV melanoma (NCT02519322). Patients received two neoadju... | Nature | Nature | 2022 Nov | 2,022 | [
"Amaria RN",
"Postow M",
"Burton EM",
"Tetzlaff MT",
"Ross MI",
"Torres-Cabala C",
"Glitza IC",
"Duan F",
"Milton DR",
"Busam K",
"Simpson L",
"McQuade JL",
"Wong MK",
"Gershenwald JE",
"Lee JE",
"Goepfert RP",
"Keung EZ",
"Fisher SB",
"Betof-Warner A",
"Shoushtari AN",
"Call... | Amaria RN | Tawbi HA | [
"Humans",
"Antibodies, Monoclonal",
"Immune Checkpoint Inhibitors",
"Melanoma",
"Neoadjuvant Therapy",
"Neoplasm Staging",
"Nivolumab",
"Macrophages",
"Drug Therapy, Combination",
"Survival Rate",
"Antibodies, Monoclonal, Humanized"
] | [
"Clinical Trial",
"Journal Article",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 611 | 7934 | 155-160 | pmc-id: PMC9607737; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/36289334/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
35537412 | 10.1016/j.ccell.2022.04.004 | Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity | Immune checkpoint blockade (ICB) therapy frequently induces immune-related adverse events. To elucidate the underlying immunobiology, we performed a deep immune analysis of intestinal, colitis, and tumor tissue from ICB-treated patients with parallel studies in preclinical models. Expression of interleukin-6 (IL-6), ne... | Cancer Cell | Cancer cell | 2022 May 9 | 2,022 | [
"Hailemichael Y",
"Johnson DH",
"Abdel-Wahab N",
"Foo WC",
"Bentebibel SE",
"Daher M",
"Haymaker C",
"Wani K",
"Saberian C",
"Ogata D",
"Kim ST",
"Nurieva R",
"Lazar AJ",
"Abu-Sbeih H",
"Fa'ak F",
"Mathew A",
"Wang Y",
"Falohun A",
"Trinh V",
"Zobniw C",
"Spillson C",
"Burk... | Hailemichael Y | Diab A | [
"Animals",
"Colitis",
"Humans",
"Immunologic Factors",
"Immunotherapy",
"Interleukin-6",
"Mice",
"Myeloid Cells",
"Neoplasms"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't",
"Research Support, N.I.H., Extramural"
] | 40 | 5 | 509-523.e6 | pmc-id: PMC9221568;manuscript-id: NIHMS1811254; | 1535-6108 | eng | https://pubmed.ncbi.nlm.nih.gov/35537412/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
35442707 | 10.1126/scitranslmed.abm6420 | A phase 1-2 trial of sitravatinib and nivolumab in clear cell renal cell carcinoma following progression on antiangiogenic therapy | The accumulation of immune-suppressive myeloid cells is a critical determinant of resistance to anti-programmed death-1 (PD-1) therapy in advanced clear cell renal cell carcinoma (ccRCC). In preclinical models, the tyrosine kinase inhibitor sitravatinib enhanced responses to anti-PD-1 therapy by modulating immune-suppr... | Sci Transl Med | Science translational medicine | 2022 Apr 20 | 2,022 | [
"Msaouel P",
"Goswami S",
"Thall PF",
"Wang X",
"Yuan Y",
"Jonasch E",
"Gao J",
"Campbell MT",
"Shah AY",
"Corn PG",
"Tam AL",
"Ahrar K",
"Rao P",
"Sircar K",
"Cohen L",
"Basu S",
"Duan F",
"Jindal S",
"Zhang Y",
"Chen H",
"Yadav SS",
"Shazer R",
"Der-Torossian H",
"All... | Msaouel P | Tannir NM | [
"Angiogenesis Inhibitors",
"Anilides",
"Carcinoma, Renal Cell",
"Female",
"Humans",
"Kidney Neoplasms",
"Liver Neoplasms",
"Male",
"Nivolumab",
"Pyridines",
"Tumor Microenvironment"
] | [
"Clinical Trial, Phase I",
"Clinical Trial, Phase II",
"Journal Article",
"Research Support, Non-U.S. Gov't",
"Research Support, N.I.H., Extramural"
] | 14 | 641 | eabm6420 | pmc-id: PMC11924199;manuscript-id: NIHMS2056464; | 1946-6234 | eng | https://pubmed.ncbi.nlm.nih.gov/35442707/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
35419587 | 10.1158/1078-0432.CCR-22-0468 | Correction: Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck | null | Clin Cancer Res | Clinical cancer research : an official journal of the American Association for Cancer Research | 2022 Apr 14 | 2,022 | [
"Ferrarotto R",
"Amit M",
"Nagarajan P",
"Rubin ML",
"Yuan Y",
"Bell D",
"El-Naggar AK",
"Johnson JM",
"Morrison WH",
"Rosenthal DI",
"Glisson BS",
"Johnson FM",
"Lu C",
"Mott FE",
"Esmaeli B",
"Diaz EM",
"Gidley PW",
"Goepfert RP",
"Lewis CM",
"Weber RS",
"Wargo JA",
"Basu... | Ferrarotto R | Gross ND | [] | [
"Published Erratum"
] | 28 | 8 | 1735 | null | 1078-0432 | eng | https://pubmed.ncbi.nlm.nih.gov/35419587/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
35065057 | 10.1016/S2468-1253(21)00427-1 | Perioperative nivolumab monotherapy versus nivolumab plus ipilimumab in resectable hepatocellular carcinoma: a randomised, open-label, phase 2 trial | Hepatocellular carcinoma has high recurrence rates after surgery; however, there are no approved standard-of-care neoadjuvant or adjuvant therapies. Immunotherapy has been shown to improve survival in advanced hepatocellular carcinoma; we therefore aimed to evaluate the safety and tolerability of perioperative immunoth... | Lancet Gastroenterol Hepatol | The lancet. Gastroenterology & hepatology | 2022 Mar | 2,022 | [
"Kaseb AO",
"Hasanov E",
"Cao HST",
"Xiao L",
"Vauthey JN",
"Lee SS",
"Yavuz BG",
"Mohamed YI",
"Qayyum A",
"Jindal S",
"Duan F",
"Basu S",
"Yadav SS",
"Nicholas C",
"Sun JJ",
"Singh Raghav KP",
"Rashid A",
"Carter K",
"Chun YS",
"Tzeng CD",
"Sakamuri D",
"Xu L",
"Sun R",... | Kaseb AO | Sharma P | [
"Aged",
"Alanine Transaminase",
"Antineoplastic Agents, Immunological",
"Antineoplastic Combined Chemotherapy Protocols",
"Aspartate Aminotransferases",
"Carcinoma, Hepatocellular",
"Female",
"Humans",
"Ipilimumab",
"Liver Neoplasms",
"Male",
"Middle Aged",
"Nivolumab",
"Perioperative Care... | [
"Clinical Trial, Phase II",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 7 | 3 | 208-218 | pmc-id: PMC8840977;manuscript-id: NIHMS1775116; | 2468-1253 | eng | https://pubmed.ncbi.nlm.nih.gov/35065057/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
35015675 | 10.1158/2643-3230.BCD-21-0130 | Checkpoint Blockade + Chemotherapy: the Right Combination for AML? | An emerging strategy to enhance the efficacy of immune checkpoint blockade in relapsed/refractory cancers is increasing immunogenic cell death via combination with cytotoxic therapies. Understanding the effects of cytotoxic and immunotherapeutic agents on immune cell populations will enable improved mechanism-based des... | Blood Cancer Discov | Blood cancer discovery | 2021 Nov | 2,021 | [
"Wei SC",
"Mancuso JJ",
"Daver N",
"Allison JP"
] | Wei SC | Allison JP | [] | [
"Journal Article",
"Comment"
] | 2 | 6 | 551-554 | pmc-id: PMC9894576; | 2643-3230 | eng | https://pubmed.ncbi.nlm.nih.gov/35015675/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
34941392 | 10.1126/science.aaz7015 | Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response | Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in cancer, but the effect of diet and supplements on this interaction is not well studied. We assessed fecal microbiota profiles, dietary habits, and commercially available probiotic supplement use in melanoma patients and performed parall... | Science | Science (New York, N.Y.) | 2021 Dec 24 | 2,021 | [
"Spencer CN",
"McQuade JL",
"Gopalakrishnan V",
"McCulloch JA",
"Vetizou M",
"Cogdill AP",
"Khan MAW",
"Zhang X",
"White MG",
"Peterson CB",
"Wong MC",
"Morad G",
"Rodgers T",
"Badger JH",
"Helmink BA",
"Andrews MC",
"Rodrigues RR",
"Morgun A",
"Kim YS",
"Roszik J",
"Hoffman ... | Spencer CN | Wargo JA | [
"Animals",
"Cohort Studies",
"Dietary Fiber",
"Fatty Acids, Volatile",
"Fecal Microbiota Transplantation",
"Feces",
"Female",
"Gastrointestinal Microbiome",
"Humans",
"Immune Checkpoint Inhibitors",
"Immunotherapy",
"Male",
"Melanoma",
"Melanoma, Experimental",
"Mice",
"Mice, Inbred C5... | [
"Journal Article",
"Observational Study",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 374 | 6575 | 1632-1640 | pmc-id: PMC8970537;manuscript-id: NIHMS1785033; | 0036-8075 | eng | https://pubmed.ncbi.nlm.nih.gov/34941392/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
34737281 | 10.1038/s41467-021-26415-4 | Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma | Cryoablation in combination with immune checkpoint therapy was previously reported to improve anti-tumor immune responses in pre-clinical studies. Here we report a pilot study of anti-CTLA-4 (tremelimumab) with (n = 15) or without (n = 14) cryoablation in patients with metastatic renal cell carcinoma (NCT02626130), 18 ... | Nat Commun | Nature communications | 2021 Nov 4 | 2,021 | [
"Campbell MT",
"Matin SF",
"Tam AL",
"Sheth RA",
"Ahrar K",
"Tidwell RS",
"Rao P",
"Karam JA",
"Wood CG",
"Tannir NM",
"Jonasch E",
"Gao J",
"Zurita AJ",
"Shah AY",
"Jindal S",
"Duan F",
"Basu S",
"Chen H",
"Espejo AB",
"Allison JP",
"Yadav SS",
"Sharma P"
] | Campbell MT | Sharma P | [
"Adult",
"Aged",
"Aged, 80 and over",
"Antibodies, Monoclonal, Humanized",
"Antineoplastic Agents, Immunological",
"CTLA-4 Antigen",
"Carcinoma, Renal Cell",
"Combined Modality Therapy",
"Cryosurgery",
"Female",
"Humans",
"Kidney Neoplasms",
"Male",
"Middle Aged",
"Neoplasm Metastasis",
... | [
"Clinical Trial, Phase I",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 12 | 1 | 6375 | pmc-id: PMC8569213; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/34737281/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
34663807 | 10.1038/s41467-021-26282-z | Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy | In contrast to the curative effect of allogenic stem cell transplantation in acute myeloid leukemia via T cell activity, only modest responses are achieved with checkpoint-blockade therapy, which might be explained by T cell phenotypes and T cell receptor (TCR) repertoires. Here, we show by paired single-cell RNA analy... | Nat Commun | Nature communications | 2021 Oct 18 | 2,021 | [
"Abbas HA",
"Hao D",
"Tomczak K",
"Barrodia P",
"Im JS",
"Reville PK",
"Alaniz Z",
"Wang W",
"Wang R",
"Wang F",
"Al-Atrash G",
"Takahashi K",
"Ning J",
"Ding M",
"Beird HC",
"Mathews JT",
"Little L",
"Zhang J",
"Basu S",
"Konopleva M",
"Marques-Piubelli ML",
"Solis LM",
... | Abbas HA | Futreal A | [
"Aged",
"Aged, 80 and over",
"Azacitidine",
"Bone Marrow",
"CD8-Positive T-Lymphocytes",
"Chromosome Deletion",
"Chromosomes, Human, Pair 7",
"Drug Resistance, Neoplasm",
"Granzymes",
"Humans",
"Immune Checkpoint Inhibitors",
"Leukemia, Myeloid, Acute",
"Middle Aged",
"Nivolumab",
"Progr... | [
"Journal Article",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 12 | 1 | 6071 | pmc-id: PMC8524723; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/34663807/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
34663638 | 10.1136/jitc-2021-002919 | Combined CTLA-4 and PD-L1 blockade in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer is associated with increased myeloid and neutrophil immune subsets in the bone microenvironment | Immune checkpoint therapy (ICT) has low response rates in patients with metastatic castration-resistant prostate cancer (mCRPC), in part due to few T cells in the tumor microenvironment (TME). Anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4) promotes intratumoral T cell infiltration but induces upregulation of... | J Immunother Cancer | Journal for immunotherapy of cancer | 2021 Oct | 2,021 | [
"Subudhi SK",
"Siddiqui BA",
"Aparicio AM",
"Yadav SS",
"Basu S",
"Chen H",
"Jindal S",
"Tidwell RSS",
"Varma A",
"Logothetis CJ",
"Allison JP",
"Corn PG",
"Sharma P"
] | Subudhi SK | Sharma P | [
"Aged",
"Aged, 80 and over",
"Antineoplastic Combined Chemotherapy Protocols",
"CTLA-4 Antigen",
"Humans",
"Immune Checkpoint Inhibitors",
"Male",
"Middle Aged",
"Neutrophils",
"Pilot Projects",
"Prostatic Neoplasms, Castration-Resistant",
"Tumor Microenvironment"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 9 | 10 | null | pmc-id: PMC8524287; | 2051-1426 | eng | https://pubmed.ncbi.nlm.nih.gov/34663638/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
34413300 | 10.1038/s41467-021-25188-0 | Nodal immune flare mimics nodal disease progression following neoadjuvant immune checkpoint inhibitors in non-small cell lung cancer | Radiographic imaging is the standard approach for evaluating the disease involvement of lymph nodes in patients with operable NSCLC although the impact of neoadjuvant immune checkpoint inhibitors (ICIs) on lymph nodes has not yet been characterized. Herein, we present an ad hoc analysis of the NEOSTAR trial (NCT0315812... | Nat Commun | Nature communications | 2021 Aug 19 | 2,021 | [
"Cascone T",
"Weissferdt A",
"Godoy MCB",
"William WN Jr",
"Leung CH",
"Lin HY",
"Basu S",
"Yadav SS",
"Pataer A",
"Mitchell KG",
"Khan MAW",
"Shi Y",
"Haymaker C",
"Solis LM",
"Parra ER",
"Kadara H",
"Wistuba II",
"Sharma P",
"Allison JP",
"Ajami NJ",
"Wargo JA",
"Jenq RR"... | Cascone T | Sepesi B | [
"Aged",
"Carcinoma, Non-Small-Cell Lung",
"Disease Progression",
"Female",
"Humans",
"Immune Checkpoint Inhibitors",
"Lung Neoplasms",
"Lymph Nodes",
"Lymphatic Metastasis",
"Male",
"Middle Aged",
"Multimodal Imaging",
"Neoadjuvant Therapy"
] | [
"Clinical Trial, Phase II",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 12 | 1 | 5045 | pmc-id: PMC8376947; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/34413300/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
34239137 | 10.1038/s41591-021-01406-6 | Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade | Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-related adverse events. Insights into biomarkers and mechanisms of response and toxicity to CICB are needed. To address this, we profiled the blood, ... | Nat Med | Nature medicine | 2021 Aug | 2,021 | [
"Andrews MC",
"Duong CPM",
"Gopalakrishnan V",
"Iebba V",
"Chen WS",
"Derosa L",
"Khan MAW",
"Cogdill AP",
"White MG",
"Wong MC",
"Ferrere G",
"Fluckiger A",
"Roberti MP",
"Opolon P",
"Alou MT",
"Yonekura S",
"Roh W",
"Spencer CN",
"Curbelo IF",
"Vence L",
"Reuben A",
"John... | Andrews MC | Wargo JA | [
"Animals",
"CTLA-4 Antigen",
"Cell Line, Tumor",
"Female",
"Gastrointestinal Microbiome",
"Humans",
"Interleukin-1beta",
"Melanoma",
"Mice",
"Mice, Inbred C57BL",
"Programmed Cell Death 1 Receptor"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 27 | 8 | 1432-1441 | pmc-id: PMC11107795;manuscript-id: NIHMS1990505; | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/34239137/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
34187851 | 10.1158/1078-0432.CCR-21-0585 | Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck | In locoregionally advanced, resectable cutaneous squamous cell carcinoma of the head and neck (CSCC-HN), surgery followed by radiotherapy is standard but can be cosmetically and functionally devastating, and many patients will have recurrence. Newly diagnosed or recurrent stage III-IVA CSCC-HN patients amenable to cura... | Clin Cancer Res | Clinical cancer research : an official journal of the American Association for Cancer Research | 2021 Aug 15 | 2,021 | [
"Ferrarotto R",
"Amit M",
"Nagarajan P",
"Rubin ML",
"Yuan Y",
"Bell D",
"El-Naggar AK",
"Johnson JM",
"Morrison WH",
"Rosenthal DI",
"Glisson BS",
"Johnson FM",
"Lu C",
"Mott FE",
"Esmaeli B",
"Diaz EM Jr",
"Gidley PW",
"Goepfert RP",
"Lewis CM",
"Weber RS",
"Wargo JA",
"B... | Ferrarotto R | Gross ND | [
"Aged",
"Female",
"Head and Neck Neoplasms",
"Humans",
"Immune Checkpoint Inhibitors",
"Immunotherapy",
"Male",
"Middle Aged",
"Neoadjuvant Therapy",
"Neoplasm Staging",
"Pilot Projects",
"Skin Neoplasms",
"Squamous Cell Carcinoma of Head and Neck"
] | [
"Clinical Trial, Phase II",
"Journal Article",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 27 | 16 | 4557-4565 | pmc-id: PMC8711237;manuscript-id: NIHMS1718764; | 1078-0432 | eng | https://pubmed.ncbi.nlm.nih.gov/34187851/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
33986125 | 10.1136/jitc-2020-002254 | Pre-existing immune status associated with response to combination of sipuleucel-T and ipilimumab in patients with metastatic castration-resistant prostate cancer | Sipuleucel-T is a US Food and Drug Administration-approved autologous cellular immunotherapy that improves survival in patients with metastatic castration-resistant prostate cancer (mCRPC). We examined whether administering ipilimumab after sipuleucel-T could modify immune and/or clinical responses to this treatment. A... | J Immunother Cancer | Journal for immunotherapy of cancer | 2021 May | 2,021 | [
"Sinha M",
"Zhang L",
"Subudhi S",
"Chen B",
"Marquez J",
"Liu EV",
"Allaire K",
"Cheung A",
"Ng S",
"Nguyen C",
"Friedlander TW",
"Aggarwal R",
"Spitzer M",
"Allison JP",
"Small EJ",
"Sharma P",
"Fong L"
] | Sinha M | Fong L | [
"Aged",
"Biomarkers, Tumor",
"CTLA-4 Antigen",
"Cancer Vaccines",
"Cells, Cultured",
"Humans",
"Immune Checkpoint Inhibitors",
"Ipilimumab",
"Lymphocyte Activation",
"Lymphocytes, Tumor-Infiltrating",
"Male",
"Middle Aged",
"Prostatic Neoplasms, Castration-Resistant",
"Th1 Cells",
"Time ... | [
"Clinical Trial, Phase II",
"Journal Article",
"Multicenter Study",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 9 | 5 | null | pmc-id: PMC8126308; | 2051-1426 | eng | https://pubmed.ncbi.nlm.nih.gov/33986125/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
33974041 | 10.1084/jem.20201811 | LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy | Immune receptors expressed on TAMs are intriguing targets for tumor immunotherapy. In this study, we found inhibitory receptor LILRB4 on a variety of intratumoral immune cell types in murine tumor models and human cancers, most prominently on TAMs. LILRB4, known as gp49B in mice, is a LILRB family receptor. Human and m... | J Exp Med | The Journal of experimental medicine | 2021 Jul 5 | 2,021 | [
"Sharma N",
"Atolagbe OT",
"Ge Z",
"Allison JP"
] | Sharma N | Allison JP | [
"Animals",
"CD4-Positive T-Lymphocytes",
"CD8-Positive T-Lymphocytes",
"Cell Line, Tumor",
"Cell Movement",
"Humans",
"Immunotherapy",
"Membrane Glycoproteins",
"Mice",
"Mice, Inbred C57BL",
"Neoplasms",
"Receptors, Immunologic",
"T-Lymphocytes, Regulatory"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 218 | 7 | null | pmc-id: PMC8117208; | 0022-1007 | eng | https://pubmed.ncbi.nlm.nih.gov/33974041/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
33820780 | 10.1158/1078-0432.CCR-20-4513 | First-in-Human Phase I Study of ABBV-085, an Antibody-Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors | Leucine-rich repeat containing 15 (LRRC15) is expressed on stromal fibroblasts in the tumor microenvironment of multiple solid tumor types and may represent an interesting target for therapy, particularly in patients with sarcomas where LRRC15 is also expressed by malignant cells. ABBV-085 is a monomethyl auristatin-E ... | Clin Cancer Res | Clinical cancer research : an official journal of the American Association for Cancer Research | 2021 Jul 1 | 2,021 | [
"Demetri GD",
"Luke JJ",
"Hollebecque A",
"Powderly JD 2nd",
"Spira AI",
"Subbiah V",
"Naumovski L",
"Chen C",
"Fang H",
"Lai DW",
"Yue H",
"Polepally AR",
"Purcell JW",
"Robinson R",
"Sharma P",
"Allison JP",
"Tolcher A",
"Villalobos VM"
] | Demetri GD | Villalobos VM | [
"Adult",
"Antineoplastic Agents",
"Bone Neoplasms",
"Humans",
"Immunoconjugates",
"Membrane Proteins",
"Neoplasms",
"Sarcoma",
"Tumor Microenvironment"
] | [
"Clinical Trial, Phase I",
"Journal Article"
] | 27 | 13 | 3556-3566 | null | 1078-0432 | eng | https://pubmed.ncbi.nlm.nih.gov/33820780/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
33811120 | 10.1158/2159-8290.CD-20-1680 | The Next Decade of Immune Checkpoint Therapy | Immune checkpoint therapy (ICT) can provide durable clinical responses and improve overall survival. However, only subsets of patients with specific tumor types respond to ICT. Thus, significant challenges remain, including understanding pathways of resistance, optimizing patient selection, improving management of immu... | Cancer Discov | Cancer discovery | 2021 Apr | 2,021 | [
"Sharma P",
"Siddiqui BA",
"Anandhan S",
"Yadav SS",
"Subudhi SK",
"Gao J",
"Goswami S",
"Allison JP"
] | Sharma P | Allison JP | [
"Drug Discovery",
"Forecasting",
"Humans",
"Immune Checkpoint Inhibitors",
"Neoplasms"
] | [
"Journal Article",
"Review"
] | 11 | 4 | 838-857 | null | 2159-8274 | eng | https://pubmed.ncbi.nlm.nih.gov/33811120/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
33603241 | 10.1038/s41591-020-01224-2 | Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial | Ipilimumab improves clinical outcomes when combined with nivolumab in metastatic non-small cell lung cancer (NSCLC), but its efficacy and impact on the immune microenvironment in operable NSCLC remain unclear. We report the results of the phase 2 randomized NEOSTAR trial (NCT03158129) of neoadjuvant nivolumab or nivolu... | Nat Med | Nature medicine | 2021 Mar | 2,021 | [
"Cascone T",
"William WN Jr",
"Weissferdt A",
"Leung CH",
"Lin HY",
"Pataer A",
"Godoy MCB",
"Carter BW",
"Federico L",
"Reuben A",
"Khan MAW",
"Dejima H",
"Francisco-Cruz A",
"Parra ER",
"Solis LM",
"Fujimoto J",
"Tran HT",
"Kalhor N",
"Fossella FV",
"Mott FE",
"Tsao AS",
... | Cascone T | Sepesi B | [
"Adult",
"Aged",
"Antineoplastic Combined Chemotherapy Protocols",
"Biomarkers, Tumor",
"Carcinoma, Non-Small-Cell Lung",
"Female",
"Humans",
"Ipilimumab",
"Lung Neoplasms",
"Male",
"Middle Aged",
"Neoadjuvant Therapy",
"Nivolumab"
] | [
"Clinical Trial, Phase II",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 27 | 3 | 504-514 | pmc-id: PMC8818318;manuscript-id: NIHMS1761424; | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/33603241/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
33257470 | 10.1158/2159-8290.CD-20-0856 | A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention | Immune checkpoint inhibitors (ICI) targeting CTLA4 or PD-1/PD-L1 have transformed cancer therapy but are associated with immune-related adverse events, including myocarditis. Here, we report a robust preclinical mouse model of ICI-associated myocarditis in which monoallelic loss of Ctla4 in the context of complete gene... | Cancer Discov | Cancer discovery | 2021 Mar | 2,021 | [
"Wei SC",
"Meijers WC",
"Axelrod ML",
"Anang NAS",
"Screever EM",
"Wescott EC",
"Johnson DB",
"Whitley E",
"Lehmann L",
"Courand PY",
"Mancuso JJ",
"Himmel LE",
"Lebrun-Vignes B",
"Wleklinski MJ",
"Knollmann BC",
"Srinivasan J",
"Li Y",
"Atolagbe OT",
"Rao X",
"Zhao Y",
"Wang... | Wei SC | Allison JP | [
"Animals",
"Biomarkers, Tumor",
"Cardiotoxicity",
"Disease Management",
"Disease Models, Animal",
"Disease Susceptibility",
"Electrocardiography",
"Humans",
"Immune Checkpoint Inhibitors",
"Mice",
"Molecular Targeted Therapy",
"Myocarditis",
"Neoplasms"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural"
] | 11 | 3 | 614-625 | pmc-id: PMC8041233;manuscript-id: NIHMS1650918; | 2159-8274 | eng | https://pubmed.ncbi.nlm.nih.gov/33257470/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
33184911 | 10.1111/nyas.14526 | Frontiers in cancer immunotherapy-a symposium report | Cancer immunotherapy has dramatically changed the approach to cancer treatment. The aim of targeting the immune system to recognize and destroy cancer cells has afforded many patients the prospect of achieving deep, long-term remission and potential cures. However, many challenges remain for achieving the goal of effec... | Ann N Y Acad Sci | Annals of the New York Academy of Sciences | 2021 Apr | 2,021 | [
"Cable J",
"Greenbaum B",
"Pe'er D",
"Bollard CM",
"Bruni S",
"Griffin ME",
"Allison JP",
"Wu CJ",
"Subudhi SK",
"Mardis ER",
"Brentjens R",
"Sosman JA",
"Cemerski S",
"Zavitsanou AM",
"Proia T",
"Egeblad M",
"Nolan G",
"Goswami S",
"Spranger S",
"Mackall CL"
] | Cable J | Mackall CL | [
"Biomarkers, Tumor",
"Cancer Vaccines",
"Combined Modality Therapy",
"Humans",
"Immune Checkpoint Inhibitors",
"Immunotherapy",
"Immunotherapy, Adoptive",
"Neoplasm Recurrence, Local",
"Neoplasms",
"Tumor Microenvironment"
] | [
"Journal Article",
"Review"
] | 1489 | 1 | 30-47 | null | 0077-8923 | eng | https://pubmed.ncbi.nlm.nih.gov/33184911/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
33046869 | 10.1038/s41591-020-1086-y | Neoadjuvant PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable high-risk urothelial carcinoma | Immune checkpoint therapy is being tested in the neoadjuvant setting for patients with localized urothelial carcinoma1,2, with one study reporting data in cisplatin-ineligible patients who received anti-PD-L1 monotherapy2. The study reported that patients with bulky tumors, a known high-risk feature defined as greater ... | Nat Med | Nature medicine | 2020 Dec | 2,020 | [
"Gao J",
"Navai N",
"Alhalabi O",
"Siefker-Radtke A",
"Campbell MT",
"Tidwell RS",
"Guo CC",
"Kamat AM",
"Matin SF",
"Araujo JC",
"Shah AY",
"Msaouel P",
"Corn P",
"Wang J",
"Papadopoulos JN",
"Yadav SS",
"Blando JM",
"Duan F",
"Basu S",
"Liu W",
"Shen Y",
"Zhang Y",
"Mac... | Gao J | Sharma P | [
"Adult",
"Aged",
"Antibodies, Monoclonal",
"Antibodies, Monoclonal, Humanized",
"Antineoplastic Agents, Immunological",
"Antineoplastic Combined Chemotherapy Protocols",
"CTLA-4 Antigen",
"Carcinoma",
"Cisplatin",
"Female",
"Humans",
"Male",
"Middle Aged",
"Neoplasm Staging",
"Programmed... | [
"Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 26 | 12 | 1845-1851 | pmc-id: PMC9768836;manuscript-id: NIHMS1850949; | 1078-8956 | eng | https://pubmed.ncbi.nlm.nih.gov/33046869/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
32796155 | 10.1172/jci.insight.142386 | Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity | Evaluation of potential immunity against the novel severe acute respiratory syndrome (SARS) coronavirus that emerged in 2019 (SARS-CoV-2) is essential for health, as well as social and economic recovery. Generation of antibody response to SARS-CoV-2 (seroconversion) may inform on acquired immunity from prior exposure, ... | JCI Insight | JCI insight | 2020 Sep 17 | 2,020 | [
"McAndrews KM",
"Dowlatshahi DP",
"Dai J",
"Becker LM",
"Hensel J",
"Snowden LM",
"Leveille JM",
"Brunner MR",
"Holden KW",
"Hopkins NS",
"Harris AM",
"Kumpati J",
"Whitt MA",
"Lee JJ",
"Ostrosky-Zeichner LL",
"Papanna R",
"LeBleu VS",
"Allison JP",
"Kalluri R"
] | McAndrews KM | Kalluri R | [
"Adaptive Immunity",
"Antibodies, Neutralizing",
"Antibodies, Viral",
"Betacoronavirus",
"COVID-19",
"COVID-19 Testing",
"Clinical Laboratory Techniques",
"Coronavirus Infections",
"Female",
"Humans",
"Male",
"Middle Aged",
"Nucleocapsid",
"Outcome Assessment, Health Care",
"Pandemics",
... | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 5 | 18 | null | pmc-id: PMC7526535; | 2379-3708 | eng | https://pubmed.ncbi.nlm.nih.gov/32796155/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
32554706 | 10.1126/scitranslmed.abc4220 | ARID1A mutation plus CXCL13 expression act as combinatorial biomarkers to predict responses to immune checkpoint therapy in mUCC | Immune checkpoint therapy (ICT) can produce durable antitumor responses in metastatic urothelial carcinoma (mUCC); however, the responses are not universal. Despite multiple approvals of ICT in mUCC, we lack predictive biomarkers to guide patient selection. The identification of biomarkers may require interrogation of ... | Sci Transl Med | Science translational medicine | 2020 Jun 17 | 2,020 | [
"Goswami S",
"Chen Y",
"Anandhan S",
"Szabo PM",
"Basu S",
"Blando JM",
"Liu W",
"Zhang J",
"Natarajan SM",
"Xiong L",
"Guan B",
"Yadav SS",
"Saci A",
"Allison JP",
"Galsky MD",
"Sharma P"
] | Goswami S | Sharma P | [
"Animals",
"Biomarkers",
"Biomarkers, Tumor",
"Chemokine CXCL13",
"DNA-Binding Proteins",
"Humans",
"Mice",
"Mutation",
"Transcription Factors",
"Tumor Microenvironment",
"Urinary Bladder Neoplasms"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 12 | 548 | null | null | 1946-6234 | eng | https://pubmed.ncbi.nlm.nih.gov/32554706/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
32296058 | 10.1038/s41467-020-15538-9 | Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma | Complex tumor microenvironmental (TME) features influence the outcome of cancer immunotherapy (IO). Here we perform immunogenomic analyses on 67 intratumor sub-regions of a PD-1 inhibitor-resistant melanoma tumor and 2 additional metastases arising over 8 years, to characterize TME interactions. We identify spatially d... | Nat Commun | Nature communications | 2020 Apr 15 | 2,020 | [
"Mitra A",
"Andrews MC",
"Roh W",
"De Macedo MP",
"Hudgens CW",
"Carapeto F",
"Singh S",
"Reuben A",
"Wang F",
"Mao X",
"Song X",
"Wani K",
"Tippen S",
"Ng KS",
"Schalck A",
"Sakellariou-Thompson DA",
"Chen E",
"Reddy SM",
"Spencer CN",
"Wiesnoski D",
"Little LD",
"Gumbs C"... | Mitra A | Futreal PA | [
"Biomarkers, Tumor",
"DNA Copy Number Variations",
"Genomics",
"Humans",
"Melanoma",
"Mutation",
"Neutrophil Activation",
"Tumor Microenvironment"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't",
"Research Support, U.S. Gov't, Non-P.H.S."
] | 11 | 1 | 1839 | pmc-id: PMC7160105; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/32296058/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
32238575 | 10.1126/scitranslmed.aaz3577 | Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer | Tumors with high mutational burden (TMB) tend to be responsive to immune checkpoint blockade (ICB) because there are neoantigens available for targeting by reinvigorated T cells, whereas those with low TMB demonstrate limited clinical responses. To determine whether antigen-specific T cell responses can be elicited aft... | Sci Transl Med | Science translational medicine | 2020 Apr 1 | 2,020 | [
"Subudhi SK",
"Vence L",
"Zhao H",
"Blando J",
"Yadav SS",
"Xiong Q",
"Reuben A",
"Aparicio A",
"Corn PG",
"Chapin BF",
"Pisters LL",
"Troncoso P",
"Tidwell RS",
"Thall P",
"Wu CJ",
"Zhang J",
"Logothetis CL",
"Futreal A",
"Allison JP",
"Sharma P"
] | Subudhi SK | Sharma P | [
"Antineoplastic Agents, Immunological",
"Biomarkers, Tumor",
"CD8-Positive T-Lymphocytes",
"Cohort Studies",
"Humans",
"Ipilimumab",
"Male",
"Prostatic Neoplasms"
] | [
"Clinical Trial",
"Journal Article",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 12 | 537 | null | null | 1946-6234 | eng | https://pubmed.ncbi.nlm.nih.gov/32238575/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
32001676 | 10.1038/s41467-019-14273-0 | Comprehensive T cell repertoire characterization of non-small cell lung cancer | Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the T cells in the lungs of patients with NSCLC. Here, we report T cell repertoire analysis in a cohort of 236 early-stage NSCLC patients. T cell repertoir... | Nat Commun | Nature communications | 2020 Jan 30 | 2,020 | [
"Reuben A",
"Zhang J",
"Chiou SH",
"Gittelman RM",
"Li J",
"Lee WC",
"Fujimoto J",
"Behrens C",
"Liu X",
"Wang F",
"Quek K",
"Wang C",
"Kheradmand F",
"Chen R",
"Chow CW",
"Lin H",
"Bernatchez C",
"Jalali A",
"Hu X",
"Wu CJ",
"Eterovic AK",
"Parra ER",
"Yusko E",
"Emers... | Reuben A | Zhang J | [
"Adult",
"Aged",
"Carcinoma, Non-Small-Cell Lung",
"Clone Cells",
"ErbB Receptors",
"Female",
"Humans",
"Lung",
"Lung Neoplasms",
"Lymphocyte Activation",
"Lymphocyte Count",
"Male",
"Middle Aged",
"Mutation",
"Survival Analysis",
"T-Lymphocytes"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't",
"Research Support, U.S. Gov't, Non-P.H.S."
] | 11 | 1 | 603 | pmc-id: PMC6992630; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/32001676/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
31925406 | 10.1038/s41577-020-0275-8 | Dissecting the mechanisms of immune checkpoint therapy | null | Nat Rev Immunol | Nature reviews. Immunology | 2020 Feb | 2,020 | [
"Sharma P",
"Allison JP"
] | Sharma P | Allison JP | [
"Animals",
"Antineoplastic Agents, Immunological",
"Antineoplastic Combined Chemotherapy Protocols",
"B7-H1 Antigen",
"CD4-Positive T-Lymphocytes",
"CD8-Positive T-Lymphocytes",
"CTLA-4 Antigen",
"Drug Resistance, Neoplasm",
"Humans",
"Mice",
"Mice, Knockout",
"Neoplasms",
"Programmed Cell D... | [
"Journal Article",
"Review"
] | 20 | 2 | 75-76 | null | 1474-1733 | eng | https://pubmed.ncbi.nlm.nih.gov/31925406/ | yBj2TdeIomEieGdeq | XPhU2PuVb7lwS7iwZ |
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