gwp string | id string | listing_status string | refrigerant string | retrofit_or_new string | safety_class string | source string | source_quote string | url string | verified_fields list | lubricant string | replaces string | trade_name string | disagreements list | also_reported list |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0 | ammonia-absorption | Acceptable | Ammonia Absorption | N | B2 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | Ammonia Absorption | | N | 0 | 0 | B2 | September 5, 1996 | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/ammonia-absorption/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | null | null |
10900 | cfc-r-12 | Phased out in 1996 | CFC R-12 | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | CFC R-12 10900 L,M MIN AB & MIN Phased out in 1996 | https://referencesource.org/hvac-component-refrigerant-compatibility/cfc-r-12/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant"
] | MIN | null | null | null | null |
4657 | cfc-r-502 | Phased out in 1996 | CFC R-502 | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | CFC R-502 4657 L,M MIN AB & MIN POE-32 Phased out in 1996 | https://referencesource.org/hvac-component-refrigerant-compatibility/cfc-r-502/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant"
] | MIN | null | null | null | null |
N/A | desiccant-cooling | Acceptable | Desiccant Cooling | N | null | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | Desiccant Cooling | | N | 0 | N/A | N/A | September 5, 1996; June 16, 2010 (pdf) (229 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/desiccant-cooling/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new"
] | null | null | null | null | null |
N/A | evaporative-cooling | Acceptable | Evaporative Cooling | N | null | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | Evaporative Cooling | | N | 0 | N/A | N/A | September 5, 1996 | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/evaporative-cooling/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new"
] | null | null | null | null | null |
1810 | hcfc-r-22 | No new equipment 2010** | HCFC R-22 | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-22 1810 L,M,H MIN AB & MIN POE-32 No new equipment 2010** | https://referencesource.org/hvac-component-refrigerant-compatibility/hcfc-r-22/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant"
] | MIN | null | null | null | null |
1182 | r-12-hcfc-r-401a | For service applications only | HCFC R-401A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-401A 1182 R-12 M,H AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: Freon™ MP39 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-12-hcfc-r-401a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | AB & MIN | R-12 | Freon™ MP39 | null | null |
1288 | r-12-hcfc-r-401b | For service applications only | HCFC R-401B | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-401B 1288 R-12 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: Freon MP66 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-12-hcfc-r-401b/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | AB & MIN | R-12 | Freon MP66 | null | null |
2788 | r-502-hcfc-r-402a | For service applications only | HCFC R-402A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-402A 2788 R-502 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: Freon HP80 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-502-hcfc-r-402a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | AB & MIN | R-502 | Freon HP80 | null | null |
2416 | r-502-hcfc-r-402b | For service applications only | HCFC R-402B | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-402B 2416 R-502 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: Freon HP81 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-502-hcfc-r-402b/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | AB & MIN | R-502 | Freon HP81 | null | null |
3152 | r-502-hcfc-r-408a | For service applications only | HCFC R-408A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-408A 3152 R-502 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: FX10 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-502-hcfc-r-408a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | AB & MIN | R-502 | FX10 | null | null |
1909 | r-12-hcfc-r-409a | For service applications only | HCFC R-409A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-409A 1909 R-12 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: FX56 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-12-hcfc-r-409a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | AB & MIN | R-12 | FX56 | null | null |
null | hcr-4141 | acceptable, subject to use conditions | HCR 4141 | null | null | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | The EPA is proposing to list HCR 4141, HFO-1234ze(E), and R-516A as acceptable, subject to use conditions, for this end-use. HCR 4141 is a higher flammability refrigerant blend with each component in the A3 Safety Group. HFO-1234ze(E) and R-516A are lower flammability refrigerants, both in the A2L Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/hcr-4141/ | [
"listing_status",
"refrigerant"
] | null | null | null | null | null |
675 | hfc-32 | Acceptable with Use Conditions: See rules for detailed conditions. | HFC-32 | N | A2L | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | HFC-32 | | N | 0 | 675 | A2L | April 10, 2015 (pdf) (769 KB); May 6, 2021 (pdf) (583 KB); April 28, 2023 (pdf) (584 KB) | Acceptable with Use Conditions: See rules for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/hfc-32/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | [] | null |
1,430 | hfc-134a | Acceptable | HFC-134a | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | HFC-134a | | R/N | 0 | 1,430 | A1 | June 16, 2010 (pdf) (229 KB); July 21, 2017 (pdf) (314 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/hfc-134a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | null | null |
1430 | hfc-r-134a | null | HFC R-134a | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-134a 1430 R-134a manufactured in India | https://referencesource.org/hvac-component-refrigerant-compatibility/hfc-r-134a/ | [
"gwp",
"refrigerant"
] | null | null | null | null | null |
3922 | r-502-hfc-r-404a | null | HFC R-404A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-502 L,M L,M POE-32 Freon HP62, Forane™ FX70 HFC R-404A 3922 R-502 L,M L,M POE-22C For use with compressors manufactured in India | https://referencesource.org/hvac-component-refrigerant-compatibility/r-502-hfc-r-404a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | R-502 | Freon HP62, Forane™ FX70 | null | null |
2107 | r-22-hfc-r-407a | null | HFC R-407A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-407A 2107 R-22 L,M L,M POE-32 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r-407a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | R-22 | null | null | null |
1774 | r-22-hfc-r-407c | null | HFC R-407C | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-407C 1774 R-22 L,M,H L,M,H POE-32 Freon 9000/KLEA 66 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r-407c/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | R-22 | Freon 9000/KLEA 66 | null | null |
1825 | r-22-hfc-r-407f | Discus™ and select refrigeration scroll models (ZF/ZB) | HFC R-407F | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-407F 1825 R-22 L,M L,M POE-32 Discus™ and select refrigeration scroll models (ZF/ZB) | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r-407f/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | R-22 | null | null | null |
3143 | r-22-hfc-r-422a | Discus supermarket racks only | HFC R-422A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-422A 3143 R-22 L,M POE-32 MIN AB Discus supermarket racks only | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r-422a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | R-22 | null | null | null |
2729 | r-22-hfc-r-422d | Discus supermarket racks only | HFC R-422D | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-422D 2729 R-22 L,M POE-32 MIN AB Discus supermarket racks only | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r-422d/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | R-22 | null | null | null |
2138 | r-22-hfc-r427a | Discus supermarket racks only | HFC-R427A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC-R427A 2138 R-22 L,M POE-32 Discus supermarket racks only | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r427a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | R-22 | null | null | null |
2265 | r-22-hfc-r-438a | Discus supermarket racks only | HFC R-438A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-438A 2265 R-22 L,M POE-32 MIN AB Discus supermarket racks only; Freon MO99 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r-438a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | R-22 | Freon MO99 | null | null |
3985 | r-502-hfc-r-507 | null | HFC R-507 | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-507 3985 R-502 L,M L,M POE-32 Genetron™ AZ50 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-502-hfc-r-507/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | R-502 | Genetron™ AZ50 | null | null |
null | hfo-1234yf | null | HFO-1234yf | null | A2L | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/hfo-1234yf/ | [
"refrigerant",
"safety_class"
] | null | null | null | [] | [
{
"as_of": "2026-08-11T00:00:00",
"field": "retrofit_or_new",
"source": "https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives",
"source_quote": "List HFO-1234yf as acceptable, subject to use co... |
null | hfo-1234ze-e | acceptable, subject to use conditions | HFO-1234ze(E) | null | A2L | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | The EPA is proposing to list HCR 4141, HFO-1234ze(E), and R-516A as acceptable, subject to use conditions, for this end-use. HCR 4141 is a higher flammability refrigerant blend with each component in the A3 Safety Group. HFO-1234ze(E) and R-516A are lower flammability refrigerants, both in the A2L Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/hfo-1234ze-e/ | [
"listing_status",
"refrigerant",
"safety_class"
] | null | null | null | null | null |
675 | r410a-r-32 | null | R-32 | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R410A M,H M,H POE-46 SP32 SP32covers VE/ZE compressors manufactured in Asia only R-32 675 | https://referencesource.org/hvac-component-refrigerant-compatibility/r410a-r-32/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces"
] | POE-46 | R410A | null | null | null |
1,990 | r-125-r-134a-r-600a-28-1-70-0-1-9 | Acceptable | R-125/R-134a/R-600a (28.1/70.0/1.9) | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-125/R-134a/R-600a (28.1/70.0/1.9) | NU-22 old composition | R/N | 0 | 1,990 | A1 | June 16, 2010 (pdf) (229 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-125-r-134a-r-600a-28-1-70-0-1-9/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | NU-22 old composition | null | null |
2,530 | r-125-r-290-r-134a-r-600a-55-0-1-0-42-5-1-5 | Acceptable | R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5) | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5) | ICOR AT-22 | R/N | 0 | 2,530 | A1 | March 29, 2006 (pdf) (181 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-125-r-290-r-134a-r-600a-55-0-1-0-42-5-1-5/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | ICOR AT-22 | null | null |
null | r-290 | null | R-290 | null | A3 | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | Using these safety groups, HFO-1234ze(E), HFC-32 and the refrigerant blends R-452B, R-454A, R-454B, R-454C, R-457A, and R-516A are in the A2L Safety Group, while R-290, R-441A, and the components of HCR 4141 are in the A3 Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-290/ | [
"refrigerant",
"safety_class"
] | null | null | null | null | null |
3 | r-290-propane | Acceptable with Use Conditions: For use in self-contained room air conditioning; see rule for detailed conditions. | R-290 (Propane) | N | A3 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-290 (Propane) | | N | 0 | 3 | A3 | April 10, 2015 (pdf) (769 KB) | Acceptable with Use Conditions: For use in self-contained room air conditioning; see rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-290-propane/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | null | null |
3 | r-290-propane-2 | For use with specific Copeland compressors manufactured in India for R-290 | R-290 propane | null | A3 | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-290 propane A3 3 POE-32 For use with specific Copeland compressors manufactured in India for R-290 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-290-propane-2/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"safety_class"
] | POE-32 | null | null | null | null |
null | r-22-r-404a | null | R-404A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-404a/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
3,920 | r-404a | Acceptable | R-404A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-404A | SUVA HP-62 | R/N | 0 | 3,920 | A1 | December 20, 2002 (pdf) (168 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-404a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | SUVA HP-62 | null | null |
null | r-22-r-407a | null | R-407A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-407a/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
2,110 | r-407a | Acceptable | R-407A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-407A | Klea 60, Klea 407A | R/N | 0 | 2,110 | A1 | January 2, 2009 (pdf) (173 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-407a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | Klea 60, Klea 407A | null | null |
1774 (1624) | r-22-r-407c | null | R-407C | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | R-22 Replacements for Great choice in systems where changing to POE oil is not practical, Freon™ NU-22B™ R-422B A1 2525 (2289) MO, AB, POE A/C, Heat Pumps elastomeric seals require replacement. Closest performance match to R-22 in A/C applications. Freon™ 407C R-407C A1 1774 (1624) POE Retrofits require a lubricant cha... | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-407c/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | POE | R-22 | Freon™ 407C | [] | null |
1,770 | r-407c | Acceptable | R-407C | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-407C | Suva 407C, Klea 407C | R/N | 0 | 1,770 | A1 | February 8, 1996 (pdf) (152 KB); December 20, 2002 (pdf) (168 KB); August 21, 2003 (pdf) (161 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-407c/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | Suva 407C, Klea 407C | null | null |
null | r-22-r-407f | null | R-407F | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-407f/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
1,820 | r-407f | Acceptable | R-407F | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-407F | Genetron Performax LT | R/N | 0 | 1,820 | A1 | October 4, 2011 (pdf) (201 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-407f/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | Genetron Performax LT | null | null |
1495 | r-22-r-404a-r-407h | Discus models and Copeland ZB and ZF scrolls for refrigerated rack retrofit | R-407H | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-407H 1495 R-22/R-404A L,M POE-32 Discus models and Copeland ZB and ZF scrolls for refrigerated rack retrofit | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-404a-r-407h/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | R-22/R-404A | null | null | null |
2,090 | r-410a | Acceptable | R-410A | N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-410A | AZ-20, Suva 9100, Puron | N | 0 | 2,090 | A1 | February 8, 1996 (pdf) (152 KB); December 20, 2002 (pdf) (168 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-410a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | AZ-20, Suva 9100, Puron | null | null |
2,230 | r-410b | Acceptable | R-410B | N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-410B | | N | 0 | 2,230 | A1 | February 8, 1996 (pdf) (152 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-410b/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | null | null |
null | r-22-r-417a | null | R-417A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-417a/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
2,350 | r-417a | Acceptable | R-417A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-417A | ISCEON 59, NU-22 | R/N | 0 | 2,350 | A1 | December 6, 1999 (pdf) (226 KB); June 16, 2010 (pdf) (229 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-417a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | ISCEON 59, NU-22 | null | null |
null | r-22-r-417b | null | R-417B | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-417b/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
1,820 | r-417c | Acceptable | R-417C | R | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-417C | Hot Shot 2 | R | 0 | 1,820 | A1 | October 4, 2011 (pdf) (201 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-417c/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | Hot Shot 2 | null | null |
null | r-22-r-421a | null | R-421A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-421a/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
2,630 | r-421a | Acceptable | R-421A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-421A | Choice R-421A | R/N | 0 | 2,630 | A1 | September 28, 2006 (pdf) (183 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-421a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | Choice R-421A | null | null |
null | r-22-r-421b | null | R-421B | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-421b/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
null | r-22-r-422a | null | R-422A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-422a/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
2525 (2289) | r-22-r-422b | null | R-422B | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | R-22 Replacements for Great choice in systems where changing to POE oil is not practical, Freon™ NU-22B™ R-422B A1 2525 (2289) MO, AB, POE A/C, Heat Pumps elastomeric seals require replacement. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-422b/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | MO, AB, POE | R-22 | Freon™ NU-22B™ | [] | null |
2,530 | r-422b | Acceptable | R-422B | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-422B | ICOR XAC1, NU-22B | R/N | 0 | 2,530 | A1 | March 29, 2006 (pdf) (181 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-422b/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | ICOR XAC1, NU-22B | null | null |
null | r-22-r-422c | null | R-422C | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-422c/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
3,390 | r-422c | Acceptable | R-422C | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-422C | ICOR XLT1 | R/N | 0 | 3,390 | A1 | March 29, 2006 (pdf) (181 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-422c/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | ICOR XLT1 | null | null |
null | r-22-r-422d | null | R-422D | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-422d/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
2,730 | r-422d | Acceptable | R-422D | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-422D | ISCEON MO29 | R/N | 0 | 2,730 | A1 | September 28, 2006 (pdf) (183 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-422d/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | ISCEON MO29 | null | null |
null | r-22-r-424a | null | R-424A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-424a/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
2,440 | r-424a | Acceptable | R-424A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-424A | RS-44 | R/N | 0 | 2,440 | A1 | September 28, 2006 (pdf) (183 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-424a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | RS-44 | null | null |
null | r-22-r-427a | null | R-427A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-427a/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
null | r-22-r427a | null | R427A | null | null | https://forane.arkema.com/en/forane-refrigerants/forane-retrofits/the-drop-in-myth/ | Arkema recommends using Forane® 427A (R427A) - The EASY RETROFIT™ for your R-22 retrofit solution. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r427a/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
2,140 | r-427a | Acceptable | R-427A | R | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-427A | Forane 427A | R | 0 | 2,140 | A1 | January 2, 2009 (pdf) (173 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-427a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | Forane 427A | null | null |
null | r-22-r-428a | null | R-428A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-428a/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
null | r-22-r-434a | null | R-434A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-434a/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
3,250 | r-434a | Acceptable | R-434A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-434A | RS-45 | R/N | 0 | 3,250 | A1 | October 4, 2007 (pdf) (163 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-434a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | RS-45 | null | null |
1,810 | r-437a | Acceptable | R-437A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-437A | KDD6, ISCEON MO49 Plus | R/N | 0 | 1,810 | A1 | January 2, 2009 (pdf) (173 KB); June 16, 2010 (pdf) (229 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-437a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | KDD6, ISCEON MO49 Plus | null | null |
2264 (2059) | r-22-r-438a | null | R-438A | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Freon™ MO99™ R-438A A1 2264 (2059) MO, AB, POE elastomeric seals require replacement. R-22 Replacements for Great choice in systems where changing to POE oil is not practical, | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-438a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | MO, AB, POE | R-22 | Freon™ MO99™ | [
{
"field": "trade_name",
"versions": [
{
"as_of": "2026-08-11T00:00:00",
"source": "https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf",
"source_quote": "Freon™ MO99™ R-438A A1 2264 (2059) MO, AB, POE elastomeric seals require replacement... | null |
2,270 | r-438a | Acceptable | R-438A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-438A | KDD5, ISCEON MO99 | R/N | 0 | 2,270 | A1 | October 4, 2007 (pdf) (163 KB); June 16, 2010 (pdf) (229 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-438a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | KDD5, ISCEON MO99 | null | null |
<5 | r-441a | Acceptable with Use Conditions: For use in self-contained room air conditioning; see rule for detailed conditions. | R-441A | N | A3 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-441A | | N | 0 | <5 | A3 | April 10, 2015 (pdf) (769 KB) | Acceptable with Use Conditions: For use in self-contained room air conditioning; see rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-441a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | [] | null |
2.5 | r-443a | Unacceptable, as of January 3, 2017. | R-443A | N | A3 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-443A | | N | 0 | 2.5 | A3 | December 1, 2016 (pdf) (969 KB) | Unacceptable, as of January 3, 2017. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-443a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | null | null |
null | r-444a | null | R-444A | null | A2L | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-444a/ | [
"refrigerant",
"safety_class"
] | null | null | null | [] | [
{
"as_of": "2026-08-11T00:00:00",
"field": "retrofit_or_new",
"source": "https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives",
"source_quote": "List the blend R-444A as acceptable, subject to ... |
1387 | r-22-r-404a-r-448a | null | R-448A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-22/R-404A L,M L,M POE-32 Solstice™ N40 R-448A 1387 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-404a-r-448a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | R-22/R-404A | Solstice™ N40 | null | null |
1396 | r-22-r-404a-r-449a | null | R-449A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-22/R-404A L,M L,M POE-32 Opteon™ XP40 R-449A 1396 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-404a-r-449a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | R-22/R-404A | Opteon™ XP40 | null | null |
1397 (1282) | r-22-r-407a-r-407f-r-449a | null | R-449A | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | R-22 , R-407A, R-407F Opteon™ XP40 R-449A A1 1397 (1282) POE Opteon™ XP40 retrofits will require replacement of critical elastomeric | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-407a-r-407f-r-449a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | POE | R-22 , R-407A, R-407F | Opteon™ XP40 | null | null |
1397 (1282) | r-404a-r-507-r-449a | null | R-449A | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Opteon™ XP40 R-449A A1 1397 (1282) POE TXVs and in most cases it is suggested to replace the R-404A power element to a R-449A power element. Consult compressor manufacturer R-404A, R-507 guidelines for necessity of demand cooling in low temperature | https://referencesource.org/hvac-component-refrigerant-compatibility/r-404a-r-507-r-449a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | POE | R-404A, R-507 | Opteon™ XP40 | null | null |
601 | r-12-r-134a-r-450a | Solstice N13 for refrigeration applications only | R-450A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-12/R-134a M,H M,H POE-32 Solstice N13 for refrigeration applications only R-450A 601 R12 L,M L,M POE-22D Compressors produced in Brazil | https://referencesource.org/hvac-component-refrigerant-compatibility/r-12-r-134a-r-450a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | R-12/R-134a | Solstice N13 | null | null |
2140 | r-22-r-404a-r-452a | OPTEON™ XP44 for U.S. and European pre-approved applications only | R-452A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-452A 2140 R-22/R-404A L,M L,M POE-32 OPTEON™ XP44 for U.S. and European pre-approved applications only | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-404a-r-452a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | R-22/R-404A | OPTEON™ XP44 | null | null |
2140 (1945) | r-404a-r-507-r-452a | null | R-452A | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | R-404A, R-507 guidelines for necessity of demand cooling in low temperature applications. Replacements Discharge temperature and mass flow match to R-404A/R-507. Best Opteon™ XP44 R-452A A1 2140 (1945) POE used in situations where liquid injection cannot be installed on the low | https://referencesource.org/hvac-component-refrigerant-compatibility/r-404a-r-507-r-452a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | POE | R-404A, R-507 | Opteon™ XP44 | null | null |
700 | r-452b | Acceptable with Use Conditions: See rule for detailed conditions. | R-452B | N | A2L | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-452B | Opteon™ XL55 | N | 0 | 700 | A2L | May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-452b/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | Opteon™ XL55 | [] | null |
null | r-453a | null | R-453A | null | A1 | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-453a/ | [
"refrigerant",
"safety_class"
] | null | null | null | [] | [
{
"as_of": "2026-08-11T00:00:00",
"field": "retrofit_or_new",
"source": "https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives",
"source_quote": "List the blend R-453A as acceptable, subject to ... |
239 | r22-r404a-r-454a | null | R-454A | null | A2L | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-454A 239 R22/R404A – L,M A2L | https://referencesource.org/hvac-component-refrigerant-compatibility/r22-r404a-r-454a/ | [
"gwp",
"refrigerant",
"replaces",
"safety_class"
] | null | R22/R404A | null | null | null |
239 (238) | r-404a-r-454a | null | R-454A | null | A2L | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Opteon™ XL40 R-454A R-404A A2L 239 (238) -54 Freon™ 410A R-410A N/A A1 2088 (1924) -61 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-404a-r-454a/ | [
"gwp",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | null | R-404A | Opteon™ XL40 | null | null |
240 | r-454a | Acceptable with Use Conditions: See rule for detailed conditions. | R-454A | N | A2L | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-454A | Opteon™ XL40 | N | 0 | 240 | A2L | May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-454a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | Opteon™ XL40 | [] | null |
466 (467) | r-410a-r-454b | null | R-454B | null | A2L | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Opteon™ XL20 R-454C R-407A A2L 148 (146) -50 Opteon™ XL41 R-454B R-410A A2L 466 (467) -51 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-410a-r-454b/ | [
"gwp",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | null | R-410A | Opteon™ XL41 | [] | [
{
"as_of": "2026-08-11T00:00:00",
"field": "lubricant",
"source": "https://prod-edam.honeywell.com/content/dam/honeywell-edam/pmt/oneam/en-us/refrigerants/documents/pmt-am-solstice-454b-applications-guide.pdf",
"source_quote": "R-454B is now a primary replacement for R-410A. Due to • \u0007Liquid dr... |
466 | r410a-r-454b | Not for retrofit into A1 systems | R-454B | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-454B 466 R410A – M,H POE-32 Not for retrofit into A1 systems | https://referencesource.org/hvac-component-refrigerant-compatibility/r410a-r-454b/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | R410A | null | null | null |
470 | r-454b | Acceptable with Use Conditions: See rule for detailed conditions. | R-454B | N | A2L | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-454B | Opteon™ XL41 | N | 0 | 470 | A2L | May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-454b/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | Opteon™ XL41 | [
{
"field": "trade_name",
"versions": [
{
"as_of": "2026-08-11T00:00:00",
"source": "https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps",
"source_quote": "R-454B | Opteon™ XL41 | N | 0 | 470 | A2L | May 6, 2021 (pdf) (583 KB) | Acce... | [
{
"as_of": "2026-08-11T00:00:00",
"field": "lubricant",
"source": "https://www.trane.com/content/dam/Trane/Commercial/global/products-systems/equipment/unitary/split-systems/rauj-cauj-20-to-120-tons/SS-APG018A-EN_11102024.pdf",
"source_quote": "than R-454B will need to be upgraded. As of this docume... |
148 | r22-r404a-r-454c | null | R-454C | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-454C 148 R22/R404A – L,M | https://referencesource.org/hvac-component-refrigerant-compatibility/r22-r404a-r-454c/ | [
"gwp",
"refrigerant",
"replaces"
] | null | R22/R404A | null | null | null |
148 (146) | r-407a-r-454c | null | R-454C | null | A2L | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Opteon™ XL20 R-454C R-407A A2L 148 (146) -50 Opteon™ XL41 R-454B R-410A A2L 466 (467) -51 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-407a-r-454c/ | [
"gwp",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | null | R-407A | Opteon™ XL20 | null | null |
148 (146) | r-407c-r-454c | null | R-454C | null | A2L | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Opteon™ XL10 R-1234yf R-134a A2L 4 (1) -21 Opteon™ XL20 R-454C R-407C A2L 148 (146) -50 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-407c-r-454c/ | [
"gwp",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | null | R-407C | Opteon™ XL20 | null | null |
150 | r-454c | Acceptable with Use Conditions: See rule for detailed conditions. | R-454C | N | A2L | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-454C | Opteon™ XL20 | N | 0 | 150 | A2L | May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-454c/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | Opteon™ XL20 | [] | null |
145 | r410a-r-455a | null | R-455A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-455A 145 R410A – M,H | https://referencesource.org/hvac-component-refrigerant-compatibility/r410a-r-455a/ | [
"gwp",
"refrigerant",
"replaces"
] | null | R410A | null | null | null |
null | r-456a | null | R-456A | null | A1 | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-456a/ | [
"refrigerant",
"safety_class"
] | null | null | null | [] | [
{
"as_of": "2026-08-11T00:00:00",
"field": "retrofit_or_new",
"source": "https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives",
"source_quote": "List the blend R-456A as acceptable, subject to ... |
140 | r-457a | Acceptable with Use Conditions: See rule for detailed conditions. | R-457A | N | A2L | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-457A | Forane® 457A | N | 0 | 140 | A2L | May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-457a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | Forane® 457A | [] | null |
1,650 | r-458a | Acceptable | R-458A | R | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-458A | Bluon TdX 20 | R | 0 | 1,650 | A1 | July 21, 2017 (pdf) (314 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-458a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | Bluon TdX 20 | null | null |
null | r-480a | null | R-480A | null | A1 | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-480a/ | [
"refrigerant",
"safety_class"
] | null | null | null | [] | [
{
"as_of": "2026-08-11T00:00:00",
"field": "retrofit_or_new",
"source": "https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives",
"source_quote": "List the blend R-480A as acceptable, subject to ... |
null | r-22-r-507a | null | R-507A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-507a/ | [
"refrigerant",
"replaces"
] | null | R-22 | null | null | null |
3,990 | r-507-r-507a | Acceptable | R-507, R-507A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-507, R-507A | AZ-50 | R/N | 0 | 3,990 | A1 | September 5, 1996; December 20, 2002 (pdf) (168 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-507-r-507a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | AZ-50 | null | null |
630 | r12-r-513a | Compressors produced in Brazil | R-513A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-513A 630 R12 L,M L,M POE-22D Compressors produced in Brazil | https://referencesource.org/hvac-component-refrigerant-compatibility/r12-r-513a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces"
] | POE-22D | R12 | null | null | null |
631 (573) | r-134a-r-513a | null | R-513A | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | R-134a Replacement for Lowest GWP retrofit refrigerant for R-134a designed systems. Opteon™ XP10 R-513A A1 631 (573) POE Elastomeric seals replacement or lubricant change not required. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-134a-r-513a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | POE | R-134a | Opteon™ XP10 | null | null |
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