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{"aliases": ["external_nacc_ad_parahippocampal_random_label_s20260724"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-external-transfer-f1d779bf3ff46410", "benchmark_track": "external_transfer", "claim_uid": "ncb-claim-7ac25481c5bb7825", "contract": {"claim_id": "external_nacc_ad_parahippocampal_random_label_s20260724", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_parahippocampal", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_ad_parahippocampal.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "4f3008493054070d99c337538fdc7b43c7924e3439236c135934493278247503", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "4f3008493054070d99c337538fdc7b43c7924e3439236c135934493278247503", "provenance": [{"prior_label": "known_null", "source_citation": "deterministic random-label control seed=20260724", "source_collection": "external_nacc_random_controls", "source_id": "external_nacc_ad_parahippocampal_random_label_s20260724", "source_mode": "external_random_control", "source_path": "data/external_benchmark/nacc_claims.csv", "target_family": "ad_aging"}], "question": "Random-label control matched to external_nacc_ad_parahippocampal.", "question_sha256": "7f4a270c5c61b59433e305d3ddea5f243b80d7a9e1f6d6909833be7f162fa3c4", "reference_id": "ncb-external-transfer-f1d779bf3ff46410", "scientific_core_sha256": "ce2fdbf9155ff552a81945c331dac6a7eb9313df8854ea2d95cbadc22192dca8", "semantic_cluster_id": "ncb-sem-7ac25481c5bb7825", "target_family": "ad_aging", "task_ids": ["ncb21-task-cc1ba1d90b8171c2"]}
{"aliases": ["ADHD_putamen"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-external-transfer-f4db51596e08aa4e", "benchmark_track": "external_transfer", "claim_uid": "ncb-claim-ea2ae86434a16888", "contract": {"claim_id": "external_cnp_adhd_putamen", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "ADHD", "control": "CONTROL", "var": "dx"}, "outcome": "smri_putamen", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_putamen negative for ADHD compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f4db51596e08aa4e0830c89f9882979171c69ea3570d1c48501c64f2d35b7a66", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "f4db51596e08aa4e0830c89f9882979171c69ea3570d1c48501c64f2d35b7a66", "provenance": [{"prior_label": "known_positive", "source_citation": "", "source_collection": "external_cnp", "source_id": "ADHD_putamen", "source_mode": "external_transfer", "source_path": "data/external_benchmark/ds000030_claims.csv", "target_family": "psychosis"}], "question": "In CNP, is smri_putamen negative for ADHD compared with CONTROL?", "question_sha256": "fd978b5ae0151f31957186f0712c9d8c4fde4906cf6ff34229da40b56586a592", "reference_id": "ncb-external-transfer-f4db51596e08aa4e", "scientific_core_sha256": "83cf33f2e2e9ac41dfc44d313289148fb000e28bf8840b42f2f4b2a3c13febd5", "semantic_cluster_id": "ncb-sem-ea2ae86434a16888", "target_family": "psychosis", "task_ids": ["ncb21-task-61e1f885b6a8ae8c"]}
{"aliases": ["ad_lateralventricle"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-external-transfer-f4e152e984bdd249", "benchmark_track": "external_transfer", "claim_uid": "ncb-claim-b74d7743c59ce81d", "contract": {"claim_id": "external_nacc_ad_lateralventricle", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "positive", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_lateralventricle", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_lateralventricle positive for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f4e152e984bdd249ddb79b28625095a2fb6eeac221687d4c90069ad598fd27ac", "migration_status": "non_executable", "modality": "sMRI", "pre_v2_contract_sha256": "f4e152e984bdd249ddb79b28625095a2fb6eeac221687d4c90069ad598fd27ac", "provenance": [{"prior_label": "known_positive", "source_citation": "AD ventricular enlargement", "source_collection": "external_nacc", "source_id": "ad_lateralventricle", "source_mode": "external_transfer", "source_path": "data/external_benchmark/nacc_claims.csv", "target_family": "ad_aging"}], "question": "In NACC, is smri_lateralventricle positive for AD compared with CN?", "question_sha256": "c8ce53c26c085c4c7ded241d9055a3093ad43e79715b3e75b45d43985a579831", "reference_id": "ncb-external-transfer-f4e152e984bdd249", "scientific_core_sha256": "7e16f197bf1204f26f18269c3084d68a97bc9ae362d83779e31b4a9323846ba3", "semantic_cluster_id": "ncb-sem-b74d7743c59ce81d", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["mci_pericalcarine"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-external-transfer-f58df52cceca9d39", "benchmark_track": "external_transfer", "claim_uid": "ncb-claim-b2110374bf984982", "contract": {"claim_id": "external_nacc_mci_pericalcarine", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "MCI", "control": "CN", "var": "dx"}, "outcome": "smri_pericalcarine", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_pericalcarine negative for MCI compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f58df52cceca9d39f9fb0be057d9e9c10ebcb6863e2a062a8847bdca42e77de9", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "f58df52cceca9d39f9fb0be057d9e9c10ebcb6863e2a062a8847bdca42e77de9", "provenance": [{"prior_label": "ad_spared_control", "source_citation": "primary visual spared in MCI", "source_collection": "external_nacc", "source_id": "mci_pericalcarine", "source_mode": "external_transfer", "source_path": "data/external_benchmark/nacc_claims.csv", "target_family": "ad_aging"}], "question": "In NACC, is smri_pericalcarine negative for MCI compared with CN?", "question_sha256": "ba27ae305e5d2673bb2d612fb3b9f4afb097ca5547af6df938e19c60589c4f69", "reference_id": "ncb-external-transfer-f58df52cceca9d39", "scientific_core_sha256": "cba2622fbd098600f8655be0e5b2f48af34c9eabcbb4d3e9ac8567927b10865c", "semantic_cluster_id": "ncb-sem-b2110374bf984982", "target_family": "ad_aging", "task_ids": ["ncb21-task-e3df98fc3f59953d"]}
{"aliases": ["SCZ_caudate"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-external-transfer-fc18a39ffb8c66fb", "benchmark_track": "external_transfer", "claim_uid": "ncb-claim-2f96bb21f27facb1", "contract": {"claim_id": "external_cnp_scz_caudate", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "SCHZ", "control": "CONTROL", "var": "dx"}, "outcome": "smri_caudate", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_caudate two_sided for SCHZ compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "fc18a39ffb8c66fb681c83d5e2c382c09f10fb5024d6d1c7f4f8b8860e260f02", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "fc18a39ffb8c66fb681c83d5e2c382c09f10fb5024d6d1c7f4f8b8860e260f02", "provenance": [{"prior_label": "known_null", "source_citation": "", "source_collection": "external_cnp", "source_id": "SCZ_caudate", "source_mode": "external_transfer", "source_path": "data/external_benchmark/ds000030_claims.csv", "target_family": "psychosis"}], "question": "In CNP, is smri_caudate two_sided for SCHZ compared with CONTROL?", "question_sha256": "60fe191239a61a263493aea1a1a7b286ecea8868d2e3268457dd7a2cfa4c4274", "reference_id": "ncb-external-transfer-fc18a39ffb8c66fb", "scientific_core_sha256": "009244f0feaa3b134fbd991282e3c6293bc216bb4152af10feadb95a52c28797", "semantic_cluster_id": "ncb-sem-2f96bb21f27facb1", "target_family": "psychosis", "task_ids": ["ncb21-task-afff5e156656f798"]}
{"aliases": ["ADHD_hippocampus"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-external-transfer-fc82caeab42cbb0b", "benchmark_track": "external_transfer", "claim_uid": "ncb-claim-8710a5bc636d93dc", "contract": {"claim_id": "external_cnp_adhd_hippocampus", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "ADHD", "control": "CONTROL", "var": "dx"}, "outcome": "smri_hippocampus", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_hippocampus negative for ADHD compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "fc82caeab42cbb0ba375c7a3cb5f9955c6f293db20dd90fef6283883c8209361", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "fc82caeab42cbb0ba375c7a3cb5f9955c6f293db20dd90fef6283883c8209361", "provenance": [{"prior_label": "known_positive", "source_citation": "", "source_collection": "external_cnp", "source_id": "ADHD_hippocampus", "source_mode": "external_transfer", "source_path": "data/external_benchmark/ds000030_claims.csv", "target_family": "psychosis"}], "question": "In CNP, is smri_hippocampus negative for ADHD compared with CONTROL?", "question_sha256": "e6d448c103f6ded476b98d67475bbc33b4e3ce95f27131ccebbe6f597a7671ca", "reference_id": "ncb-external-transfer-fc82caeab42cbb0b", "scientific_core_sha256": "16d1cf18da8dcbcfe503122ec9e9c9d495002cbddc40d471537a07e5fb047f48", "semantic_cluster_id": "ncb-sem-8710a5bc636d93dc", "target_family": "psychosis", "task_ids": ["ncb21-task-b41d1e817622f9ee"]}
{"aliases": ["miriad_ad"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-pending-34462bc3fe7aad1f", "benchmark_track": "scientific", "claim_uid": "ncb-claim-34462bc3fe7aad1f", "contract": null, "contract_sha256": null, "migration_status": "non_executable", "modality": "unknown", "pre_v2_contract_sha256": null, "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Jack et al. 2018 NIA-AA framework [VERIFY]", "source_collection": "legacy_scientific", "source_id": "miriad_ad", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For AD structural marker in MIRIAD in MIRIAD/sMRI, using MIRIAD as discovery and ADNI/OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "question_sha256": "afbf41464b9fce6ca2feb01e6774b00929aa01d67bc30abc9bbbdcf916a68601", "reference_id": "ncb-pending-34462bc3fe7aad1f", "scientific_core_sha256": "", "semantic_cluster_id": "ncb-sem-34462bc3fe7aad1f", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["nacc_csf_ptau_smri"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-pending-47bb812b9cbd8434", "benchmark_track": "scientific", "claim_uid": "ncb-claim-47bb812b9cbd8434", "contract": null, "contract_sha256": null, "migration_status": "non_executable", "modality": "unknown", "pre_v2_contract_sha256": null, "provenance": [{"prior_label": "candidate_unknown", "source_citation": "[VERIFY]", "source_collection": "legacy_scientific", "source_id": "nacc_csf_ptau_smri", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For CSF p-tau association with regional volumes in NACC/sMRI+CSF, using NACC_CSF_DISC as discovery and NACC_CSF_REP as replication, test the claim with expected direction negative and adjust for age;eTIV;site when available.", "question_sha256": "9597ad3c016445896abcc0249314fe166790a63773247ca64a04ffb4e8de5f3f", "reference_id": "ncb-pending-47bb812b9cbd8434", "scientific_core_sha256": "", "semantic_cluster_id": "ncb-sem-47bb812b9cbd8434", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["ad_region_adni_oasis3"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-pending-4a9f7d09a17c74f8", "benchmark_track": "scientific", "claim_uid": "ncb-claim-4a9f7d09a17c74f8", "contract": null, "contract_sha256": null, "migration_status": "non_executable", "modality": "unknown", "pre_v2_contract_sha256": null, "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Jack et al. 2018 NIA-AA framework [VERIFY]", "source_collection": "legacy_scientific", "source_id": "ad_region_adni_oasis3", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For AD diagnosis fMRI regional difference in fMRI-region, using ADNI_fMRI as discovery and OASIS3_fMRI as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "question_sha256": "22a5ff9d6af78ac3c60991f0063fa4fffedd02d8349680283e4ee8da6f47081e", "reference_id": "ncb-pending-4a9f7d09a17c74f8", "scientific_core_sha256": "", "semantic_cluster_id": "ncb-sem-4a9f7d09a17c74f8", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["nacc_csf_abeta_smri"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-pending-661468a337ef8336", "benchmark_track": "scientific", "claim_uid": "ncb-claim-661468a337ef8336", "contract": null, "contract_sha256": null, "migration_status": "non_executable", "modality": "unknown", "pre_v2_contract_sha256": null, "provenance": [{"prior_label": "candidate_unknown", "source_citation": "[VERIFY]", "source_collection": "legacy_scientific", "source_id": "nacc_csf_abeta_smri", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For CSF amyloid beta association with regional volumes in NACC/sMRI+CSF, using NACC_CSF_DISC as discovery and NACC_CSF_REP as replication, test the claim with expected direction positive and adjust for age;eTIV;site when available.", "question_sha256": "772d0476519e06fd620f0aae7906cc3931a01bd647d0a83188708363dcdec6e0", "reference_id": "ncb-pending-661468a337ef8336", "scientific_core_sha256": "", "semantic_cluster_id": "ncb-sem-661468a337ef8336", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["aibl_ad_smri"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-pending-6f8d67212a205367", "benchmark_track": "scientific", "claim_uid": "ncb-claim-6f8d67212a205367", "contract": null, "contract_sha256": null, "migration_status": "non_executable", "modality": "unknown", "pre_v2_contract_sha256": null, "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Jack et al. 2018 NIA-AA framework [VERIFY]", "source_collection": "legacy_scientific", "source_id": "aibl_ad_smri", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For AD structural marker in AIBL in AIBL/AD, using AIBL as discovery and ADNI/OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "question_sha256": "53758ba03f3f27e634bab7ad2b6ed8515007e88d084cd98965c332ec34a3e245", "reference_id": "ncb-pending-6f8d67212a205367", "scientific_core_sha256": "", "semantic_cluster_id": "ncb-sem-6f8d67212a205367", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["nacc_csf_ttau_smri"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-pending-936a5d784ee98820", "benchmark_track": "scientific", "claim_uid": "ncb-claim-936a5d784ee98820", "contract": null, "contract_sha256": null, "migration_status": "non_executable", "modality": "unknown", "pre_v2_contract_sha256": null, "provenance": [{"prior_label": "candidate_unknown", "source_citation": "[VERIFY]", "source_collection": "legacy_scientific", "source_id": "nacc_csf_ttau_smri", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For CSF t-tau association with regional volumes in NACC/sMRI+CSF, using NACC_CSF_DISC as discovery and NACC_CSF_REP as replication, test the claim with expected direction negative and adjust for age;eTIV;site when available.", "question_sha256": "53fd7bf21ed0097118da019906f3556663499cd898358df1f52fde0c3c1c9609", "reference_id": "ncb-pending-936a5d784ee98820", "scientific_core_sha256": "", "semantic_cluster_id": "ncb-sem-936a5d784ee98820", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["ad_dyno_adni_oasis3"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-pending-971e3a317a0b72b1", "benchmark_track": "scientific", "claim_uid": "ncb-claim-971e3a317a0b72b1", "contract": null, "contract_sha256": null, "migration_status": "non_executable", "modality": "unknown", "pre_v2_contract_sha256": null, "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Jack et al. 2018 NIA-AA framework [VERIFY]", "source_collection": "legacy_scientific", "source_id": "ad_dyno_adni_oasis3", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For AD diagnosis fMRI dynamics difference in fMRI-dynamics, using ADNI_fMRI as discovery and OASIS3_fMRI as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "question_sha256": "50f11707fa2c40ccf0f1eb8a0028e25b909002f8c9958562d1755cde3da3920f", "reference_id": "ncb-pending-971e3a317a0b72b1", "scientific_core_sha256": "", "semantic_cluster_id": "ncb-sem-971e3a317a0b72b1", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["nacc_age_smri_split"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-pending-c109790dc989f6d7", "benchmark_track": "scientific", "claim_uid": "ncb-claim-c109790dc989f6d7", "contract": null, "contract_sha256": null, "migration_status": "non_executable", "modality": "unknown", "pre_v2_contract_sha256": null, "provenance": [{"prior_label": "known_positive", "source_citation": "Fjell and Walhovd 2010 review", "source_collection": "legacy_scientific", "source_id": "nacc_age_smri_split", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For age association with regional brain volumes in NACC/sMRI, using NACC_DISC as discovery and NACC_REP as replication, test the claim with expected direction negative and adjust for eTIV;site when available.", "question_sha256": "8e23f2c7a4ffc3f43d22700eee998804250dd049d0bae6d893295c0f1732b068", "reference_id": "ncb-pending-c109790dc989f6d7", "scientific_core_sha256": "", "semantic_cluster_id": "ncb-sem-c109790dc989f6d7", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["nacc_mri_ad"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-pending-c92eff7950758b43", "benchmark_track": "scientific", "claim_uid": "ncb-claim-c92eff7950758b43", "contract": null, "contract_sha256": null, "migration_status": "non_executable", "modality": "unknown", "pre_v2_contract_sha256": null, "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Jack et al. 2018 NIA-AA framework [VERIFY]", "source_collection": "legacy_scientific", "source_id": "nacc_mri_ad", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For AD structural marker in NACC in NACC/sMRI, using NACC as discovery and ADNI/OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "question_sha256": "260cb2d99ba3cabf4f2f3f511ffc947dc5683fee4dfa46f266543c4113b75abb", "reference_id": "ncb-pending-c92eff7950758b43", "scientific_core_sha256": "", "semantic_cluster_id": "ncb-sem-c92eff7950758b43", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["ad_fc_adni_oasis3"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-pending-d98528cc9b996755", "benchmark_track": "scientific", "claim_uid": "ncb-claim-d98528cc9b996755", "contract": null, "contract_sha256": null, "migration_status": "non_executable", "modality": "unknown", "pre_v2_contract_sha256": null, "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Jack et al. 2018 NIA-AA framework [VERIFY]", "source_collection": "legacy_scientific", "source_id": "ad_fc_adni_oasis3", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For AD diagnosis FC difference in fMRI-FC, using ADNI_fMRI as discovery and OASIS3_fMRI as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "question_sha256": "15a8a804f1242ccf904dffb4c425fceb8119508a51e053a94e73afa62112218e", "reference_id": "ncb-pending-d98528cc9b996755", "scientific_core_sha256": "", "semantic_cluster_id": "ncb-sem-d98528cc9b996755", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["adhd_q034"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-03136ab7c6bb7990", "benchmark_track": "scientific", "claim_uid": "ncb-claim-b4a8d5bfb3357c42", "contract": {"claim_id": "adhd_q034", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, do ADHD cases (dx=1.0) differ from controls (dx=0.0) in Default-Somatomotor connectivity (fc_fc_Default_SomMot_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "03136ab7c6bb7990d987f647394f6865d014527a752393660750e24e0cd5b01d", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "03136ab7c6bb7990d987f647394f6865d014527a752393660750e24e0cd5b01d", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q034", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, do ADHD cases (dx=1.0) differ from controls (dx=0.0) in Default-Somatomotor connectivity (fc_fc_Default_SomMot_z), with no additional covariates?", "question_sha256": "16da99455100e73d7cbf0d1821891a26f50e588e4113c7461a6afac868eb9e9f", "reference_id": "ncb-scientific-03136ab7c6bb7990", "scientific_core_sha256": "b9998b52069e6ce1e9294fcd17aaa48a5f6eeffc72441fe597ab4c0e57fa86a9", "semantic_cluster_id": "ncb-sem-b4a8d5bfb3357c42", "target_family": "adhd", "task_ids": ["ncb21-task-fd19e9541079da97"]}
{"aliases": ["sex_smri_hippocampus_gsp_oasis3_cn"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-042202d5c660975c", "benchmark_track": "scientific", "claim_uid": "ncb-claim-bf0084ade08ee738", "contract": {"claim_id": "sex_smri_hippocampus_gsp_oasis3_cn", "covariates": ["age", "eTIV", "site"], "discovery_cohort": "GSP_DISC", "estimand": {"direction": "negative", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "smri_hippocampus*", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 3, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx in [\"HC\", \"CN\"]", "question": "For sex difference in eTIV-adjusted hippocampal volume in sMRI, using GSP as discovery and OASIS3_CN as replication, test the claim with expected direction female_minus_male negative on hippocampal volume after age and eTIV adjustment and adjust for age;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "042202d5c660975ce3b91ee7e685400356d305baaf7cc0193e6cae7f20c340b0", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "042202d5c660975ce3b91ee7e685400356d305baaf7cc0193e6cae7f20c340b0", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Ritchie et al. 2018 Cerebral Cortex", "source_collection": "legacy_scientific", "source_id": "sex_smri_hippocampus_gsp_oasis3_cn", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "normative_fmri"}], "question": "For sex difference in eTIV-adjusted hippocampal volume in sMRI, using GSP as discovery and OASIS3_CN as replication, test the claim with expected direction female_minus_male negative on hippocampal volume after age and eTIV adjustment and adjust for age;eTIV when available.", "question_sha256": "271364dcac5fcb50955219f26ffdda02f2480812446fbee6c6e31b269aab528b", "reference_id": "ncb-scientific-042202d5c660975c", "scientific_core_sha256": "beebc1382441cefd850960055e5dbc81474a556df49aaf22c3a9b0a4fbda2c68", "semantic_cluster_id": "ncb-sem-bf0084ade08ee738", "target_family": "normative_fmri", "task_ids": ["ncb21-task-5dc738265f5849e3"]}
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{"aliases": ["ad_aging_q034"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-0945ff60b5d68ba8", "benchmark_track": "scientific", "claim_uid": "ncb-claim-e7f683ba9f4d54de", "contract": {"claim_id": "ad_aging_q034", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_entorhinal", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In ADNI_DISC, among CN participants, is older age associated with lower smri_entorhinal, adjusting for sex?", "replication_cohorts": ["ADNI_REP", "OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0945ff60b5d68ba89a298e0d5c7f9a2de1625b057bca524e15324d9708ecf806", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "0945ff60b5d68ba89a298e0d5c7f9a2de1625b057bca524e15324d9708ecf806", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q034", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, among CN participants, is older age associated with lower smri_entorhinal, adjusting for sex?", "question_sha256": "4cb9377ded9feb6d76bf5054a804e16afeeb4fa9f472aa35762588854bd2d7b8", "reference_id": "ncb-scientific-0945ff60b5d68ba8", "scientific_core_sha256": "d200db352b9163511dea58bdcde2dc1a8a423dbc3b627c10d03e4b2fe7a625c2", "semantic_cluster_id": "ncb-sem-e7f683ba9f4d54de", "target_family": "ad_aging", "task_ids": ["ncb21-task-3df4d7ede4eced5b"]}
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{"aliases": ["asd_q020"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-09bce8d2747a588b", "benchmark_track": "scientific", "claim_uid": "ncb-claim-d8da72dac171db8f", "contract": {"claim_id": "asd_q020", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Limbic", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Limbic differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "09bce8d2747a588b48e78179d64eef021ef591c62d258c96db87fa1a187763be", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "09bce8d2747a588b48e78179d64eef021ef591c62d258c96db87fa1a187763be", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q020", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Limbic differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "84af72908c7b8f321c78d60aac374797544378b154f67c119a75696f810078ef", "reference_id": "ncb-scientific-09bce8d2747a588b", "scientific_core_sha256": "fab01154d6c71c30855e10af8840ebc9d8582145c4279bcd7cf1d879064faf5e", "semantic_cluster_id": "ncb-sem-d8da72dac171db8f", "target_family": "asd", "task_ids": ["ncb21-task-ba5da3b4e0cc513f"]}
{"aliases": ["ad_aging_q037", "ad_aging_q040"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-0b054fd85acaa063", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2e39c87cf3178a9c", "contract": {"claim_id": "ad_aging_q037", "covariates": ["age", "sex", "site"], "discovery_cohort": "OASIS3_fMRI_DISC", "estimand": {"direction": "negative", "group": {"case": "2", "control": "0", "var": "dx"}, "outcome": "fc_fc_Default_Default_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_fMRI_DISC, with OASIS3_fMRI_REP as a replication cohort, is diagnosis code 2 associated with lower fc_fc_Default_Default_z than diagnosis code 0, adjusting for age and sex?", "replication_cohorts": ["OASIS3_fMRI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0b054fd85acaa06382e368b06e24cb23876d673dda29faac3b690645e449b6d5", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "0b054fd85acaa06382e368b06e24cb23876d673dda29faac3b690645e449b6d5", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q037", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}, {"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q040", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In OASIS3_fMRI_DISC, with OASIS3_fMRI_REP as a replication cohort, is diagnosis code 2 associated with lower fc_fc_Default_Default_z than diagnosis code 0, adjusting for age and sex?", "question_sha256": "bb0702c42caf974ef7f34c2f9d387c0bf6e1c67a9e7c41134334a9af131dea6b", "reference_id": "ncb-scientific-0b054fd85acaa063", "scientific_core_sha256": "b8b4ef90332019d8a52137f316a51b0fb1205f22805b88155bdc0003dc62b925", "semantic_cluster_id": "ncb-sem-2e39c87cf3178a9c", "target_family": "ad_aging", "task_ids": ["ncb21-task-e84b490f18a61545"]}
{"aliases": ["adhd_q021"], "alignment_disposition": "repairable_contract", "benchmark_case_id": "ncb-scientific-0bccd4e0b2409e23", "benchmark_track": "scientific", "claim_uid": "ncb-claim-860a47454142ac22", "contract": {"claim_id": "adhd_q021", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "1", "control": "0", "var": "dx"}, "outcome": "fc_fc_Cont_Default_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, among diagnostic categories, does ADHD-combined type (dx=1) differ from controls (dx=0) in Control-Default connectivity (fc_fc_Cont_Default_z), with no additional covariates, and is the same contrast evaluable in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "89eeb82766aa49d0eae879688b4dcfa871807b5faa70ce3bb14f16084b4beb4c", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "0bccd4e0b2409e237c36e6941be3ed85299ce31401a8e95189e7800e5d393c99", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q021", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, among diagnostic categories, does ADHD-combined type (dx=1) differ from controls (dx=0) in Control-Default connectivity (fc_fc_Cont_Default_z), with no additional covariates, and is the same contrast evaluable in ADHD200_REP?", "question_sha256": "e29b95fbe57d2d0bc975e13e732b5659c268a8998d0f486786a226e7fff9c820", "reference_id": "ncb-scientific-0bccd4e0b2409e23", "scientific_core_sha256": "70f8501e93817b3ed1124b91c60d8b11a9e7a7755259d4c0663145e87f037a44", "semantic_cluster_id": "ncb-sem-860a47454142ac22", "target_family": "adhd", "task_ids": ["ncb21-task-29da26499534583a"]}
{"aliases": ["asd_q007"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-0c04451321f8aa46", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2166e66544e56e96", "contract": {"claim_id": "asd_q007", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_HOLDOUT", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_HOLDOUT, is fc_within_network lower in ASD than HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0c04451321f8aa463f1d1bfe0e785823e00d716a57d204c1b000827ea22d686c", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "0c04451321f8aa463f1d1bfe0e785823e00d716a57d204c1b000827ea22d686c", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q007", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE1_HOLDOUT, is fc_within_network lower in ASD than HC participants using dx as the predictor and no additional covariates?", "question_sha256": "e908ac047680693321dcbc88a5558e4bce5ce73837d573f26ccd9441514e2c73", "reference_id": "ncb-scientific-0c04451321f8aa46", "scientific_core_sha256": "8c47699fe8b988dbd5944a898ad307bddde2890fbf81b108ee63986e93226ba0", "semantic_cluster_id": "ncb-sem-2166e66544e56e96", "target_family": "asd", "task_ids": ["ncb21-task-853f5a3df22e30b3"]}
{"aliases": ["adhd_q013"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-0c84ae301c0de1ab", "benchmark_track": "scientific", "claim_uid": "ncb-claim-e481c0acf618bcd8", "contract": {"claim_id": "adhd_q013", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with lower Control-Default connectivity (fc_fc_Cont_Default_z), with no additional covariates, and does ADHD200_REP show the same direction?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0c84ae301c0de1abddf331f69604f3b8af8886ac64452c7b483f854ee385617a", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "0c84ae301c0de1abddf331f69604f3b8af8886ac64452c7b483f854ee385617a", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q013", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with lower Control-Default connectivity (fc_fc_Cont_Default_z), with no additional covariates, and does ADHD200_REP show the same direction?", "question_sha256": "9364c7f8a618b162b808f7c05ac5c450034498633f3de5ddda06072cfba642ba", "reference_id": "ncb-scientific-0c84ae301c0de1ab", "scientific_core_sha256": "dc7c13d757028463ea50a59f333d62281a83532b249bfd76b96a550cd6181d07", "semantic_cluster_id": "ncb-sem-e481c0acf618bcd8", "target_family": "adhd", "task_ids": ["ncb21-task-abed0ba3d73e33a5"]}
{"aliases": ["adhd_q048"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-0cdad63325891f3d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a7e5d3c11d8415e9", "contract": {"claim_id": "adhd_q048", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ABCD_DISC and ADHD200_DISC, using each cohort's available ADHD-control coding separately (ABCD dx=1.0 vs 0.0 excluding missing dx; ADHD200 dx in {1,2,3} vs 0), is the ADHD association with Control-Default connectivity (fc_fc_Cont_Default_z) in the same direction, with no additional covariates?", "replication_cohorts": ["ADHD200_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0cdad63325891f3d72ae9d25459e2fb0c7ad22a7911a1534b14c6b1dfdc02f28", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "0cdad63325891f3d72ae9d25459e2fb0c7ad22a7911a1534b14c6b1dfdc02f28", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q048", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "Across ABCD_DISC and ADHD200_DISC, using each cohort's available ADHD-control coding separately (ABCD dx=1.0 vs 0.0 excluding missing dx; ADHD200 dx in {1,2,3} vs 0), is the ADHD association with Control-Default connectivity (fc_fc_Cont_Default_z) in the same direction, with no additional covariates?", "question_sha256": "b147e37145b8404255308206cc5af8896c29428cd9abb5b38d7cb1275b6e32bc", "reference_id": "ncb-scientific-0cdad63325891f3d", "scientific_core_sha256": "f8efa36335b788491be8e1a6bd1f3b1bff55df2b7ab047500b568a701bee9244", "semantic_cluster_id": "ncb-sem-a7e5d3c11d8415e9", "target_family": "adhd", "task_ids": ["ncb21-task-6b0da08282f4c1c9"]}
{"aliases": ["ad_aging_q044"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-0cf9bf17a3cb10a7", "benchmark_track": "scientific", "claim_uid": "ncb-claim-eb1ef11427c8f00d", "contract": {"claim_id": "ad_aging_q044", "covariates": ["sex", "site"], "discovery_cohort": "OASIS3_fMRI_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_Cont_Default_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0\"", "question": "In OASIS3_fMRI_DISC, among participants with diagnosis code 0, does fc_fc_Cont_Default_z change with older age, adjusting for sex?", "replication_cohorts": ["OASIS3_fMRI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0cf9bf17a3cb10a706661b585964be67b5928087882dc93e7b80224dac8a3534", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "0cf9bf17a3cb10a706661b585964be67b5928087882dc93e7b80224dac8a3534", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q044", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In OASIS3_fMRI_DISC, among participants with diagnosis code 0, does fc_fc_Cont_Default_z change with older age, adjusting for sex?", "question_sha256": "02d7db3556f6fc5a985b97d4310855d18f6e35d6b60b8eb7f60e9a79547a3d76", "reference_id": "ncb-scientific-0cf9bf17a3cb10a7", "scientific_core_sha256": "83cf598d9c82286cb22708a167293a7657c0e1a9657049d6fcfb9accb9038d74", "semantic_cluster_id": "ncb-sem-eb1ef11427c8f00d", "target_family": "ad_aging", "task_ids": ["ncb21-task-fd552b642761b2dd"]}
{"aliases": ["adhd_q044"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-0d57166941ee6987", "benchmark_track": "scientific", "claim_uid": "ncb-claim-1dbd5384a30c6230", "contract": {"claim_id": "adhd_q044", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Vis_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered within-Visual connectivity (fc_fc_Vis_Vis_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0d57166941ee6987a8e94a201d566f6551e2f9cde82cc2d83fe95e4b02d7cf43", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "0d57166941ee6987a8e94a201d566f6551e2f9cde82cc2d83fe95e4b02d7cf43", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q044", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered within-Visual connectivity (fc_fc_Vis_Vis_z), with no additional covariates?", "question_sha256": "a7fab3000d3573d6d3f8433968329d071578091c5586b9190a0c00dba446da14", "reference_id": "ncb-scientific-0d57166941ee6987", "scientific_core_sha256": "fbcfc4528da4423574b7c3cc1988b7d6ab6a19eacca7d398d3af6413e83813ff", "semantic_cluster_id": "ncb-sem-1dbd5384a30c6230", "target_family": "adhd", "task_ids": ["ncb21-task-8783c84319c13ec7"]}
{"aliases": ["normative_fmri_048"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-0efe8c9435d8ffdf", "benchmark_track": "scientific", "claim_uid": "ncb-claim-c16d4a3bbbd3af4d", "contract": {"claim_id": "normative_fmri_048", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "cohort in [\"HCP_DISC\", \"HCP_REP\"] or dx == \"0.0\"", "question": "Across ABCD_DISC and HCP_DISC, with replication in ABCD_REP and HCP_REP, is higher cognition associated with lower default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for age and sex within each cohort and restricting ABCD to dx=0.0?", "replication_cohorts": ["HCP_DISC", "ABCD_REP", "HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0efe8c9435d8ffdf5e3a10cd931fb791519373a7a547403b10409137517788bb", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "0efe8c9435d8ffdf5e3a10cd931fb791519373a7a547403b10409137517788bb", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_048", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "Across ABCD_DISC and HCP_DISC, with replication in ABCD_REP and HCP_REP, is higher cognition associated with lower default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for age and sex within each cohort and restricting ABCD to dx=0.0?", "question_sha256": "eff33b6c00975fef43f84b9f18b7e38e6bd5b0b73bb12d8e31c36dd245908097", "reference_id": "ncb-scientific-0efe8c9435d8ffdf", "scientific_core_sha256": "7cf8f940cd4314ae7eafd03b4048314ce79316c593b8bfa18bd4ed766d57d2e9", "semantic_cluster_id": "ncb-sem-c16d4a3bbbd3af4d", "target_family": "normative_fmri", "task_ids": ["ncb21-task-f77afb2c1b6beb4b"]}
{"aliases": ["pubmed_32726311_pmid32726311_ent_resistance"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-0f508c95b4a3bf2f", "benchmark_track": "scientific", "claim_uid": "ncb-claim-25aa4911649f7d30", "contract": {"claim_id": "pubmed_32726311_pmid32726311_ent_resistance", "covariates": ["sex", "eTIV"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "smri_entorhinal", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "For literature-grounded Older age among cognitively normal adults, with regional contrast involving entorhinal cortex effect on Entorhinal cortex age-related atrophy or MRI integrity in combined functional-structural MRI in the primary study; structural MRI in secondary analyses, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction two_sided and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0f508c95b4a3bf2f8378534e90302d62391a9fa42ce7d40f63b60d7d76091c99", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "0f508c95b4a3bf2f8378534e90302d62391a9fa42ce7d40f63b60d7d76091c99", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:32726311; DOI:10.1371/journal.pone.0234255", "source_collection": "stage2_current", "source_id": "pubmed_32726311_pmid32726311_ent_resistance", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "For literature-grounded Older age among cognitively normal adults, with regional contrast involving entorhinal cortex effect on Entorhinal cortex age-related atrophy or MRI integrity in combined functional-structural MRI in the primary study; structural MRI in secondary analyses, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction two_sided and adjust for age;eTIV;sex when available.", "question_sha256": "369145284d194fe1ac5a6007ba75dfe2b1a2f431fdb95d7e0b415b41597567a0", "reference_id": "ncb-scientific-0f508c95b4a3bf2f", "scientific_core_sha256": "1459c5ad026f1a2e9fef47cae988352948ad6e63bfa00a67e3c909e0b186bc02", "semantic_cluster_id": "ncb-sem-25aa4911649f7d30", "target_family": "ad_aging", "task_ids": ["ncb21-task-53aa9c77ecfafcc8"]}
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{"aliases": ["asd_q043"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-1329501baee4943a", "benchmark_track": "scientific", "claim_uid": "ncb-claim-9610f92c93cdb893", "contract": {"claim_id": "asd_q043", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_SalVentAttn_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1329501baee4943a8d1925394f1bd0c531b39a4df9d4412f31a9e326f49d547b", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "1329501baee4943a8d1925394f1bd0c531b39a4df9d4412f31a9e326f49d547b", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q043", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_SalVentAttn_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "34ad74317355f61b0e51248e3cd2fc0fa2e50d4425bd51e8f4a23e584818898f", "reference_id": "ncb-scientific-1329501baee4943a", "scientific_core_sha256": "08be9303687caccc62e9998ce1e2dd53514e433d2a392c554ba3e66bd5dd0dce", "semantic_cluster_id": "ncb-sem-9610f92c93cdb893", "target_family": "asd", "task_ids": ["ncb21-task-5f409c0792f04b6a"]}
{"aliases": ["normative_fmri_029"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-138026bd7cce20e7", "benchmark_track": "scientific", "claim_uid": "ncb-claim-3e39a00107258f29", "contract": {"claim_id": "normative_fmri_029", "covariates": ["age", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_Default_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, do females and males differ in default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for age and cognition?", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "138026bd7cce20e79ee446546ae110932c552bcf6e4739a76d5c5861dca44b69", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "138026bd7cce20e79ee446546ae110932c552bcf6e4739a76d5c5861dca44b69", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_029", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, do females and males differ in default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for age and cognition?", "question_sha256": "e5049a9b2e8be9fd15f4ecb8e1e7bd6ca6f4184d49b36ac1d7d02807dcbaf8ad", "reference_id": "ncb-scientific-138026bd7cce20e7", "scientific_core_sha256": "cb4a3d3501c80b99d64551fb50814851f197a405a77a0e29cbeeac09f2191995", "semantic_cluster_id": "ncb-sem-3e39a00107258f29", "target_family": "normative_fmri", "task_ids": ["ncb21-task-899f07fc4e50962f"]}
{"aliases": ["asd_q037"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-149b1f2aeda4fcb1", "benchmark_track": "scientific", "claim_uid": "ncb-claim-7ccbd6c1a37ab02b", "contract": {"claim_id": "asd_q037", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SomMot_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_SomMot_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "149b1f2aeda4fcb1612b5edd3c9ba5d3fdc4cc18d9c5aa1afa53e32c85ed567e", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "149b1f2aeda4fcb1612b5edd3c9ba5d3fdc4cc18d9c5aa1afa53e32c85ed567e", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q037", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_SomMot_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "4bd4361ba4cf7dc3a6986e8a19a45870dac7fb4eb6849d8f90b89e5b6ad790d7", "reference_id": "ncb-scientific-149b1f2aeda4fcb1", "scientific_core_sha256": "7ab28dcdca4b51c56d5a1a1d9d87b587c0bf6ac49823ccce07f87d58ae19eba1", "semantic_cluster_id": "ncb-sem-7ccbd6c1a37ab02b", "target_family": "asd", "task_ids": ["ncb21-task-96d84cbe7248ad9a"]}
{"aliases": ["asd_q045"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-1518a0abab435142", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2b233c027e6c128b", "contract": {"claim_id": "asd_q045", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Vis_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1518a0abab43514213f4d83221121b85df589c0db1f51783ab24f10b187a989c", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "1518a0abab43514213f4d83221121b85df589c0db1f51783ab24f10b187a989c", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q045", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Vis_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "2e8ca1fa68a1ceefd584df107b0c74c0f6322971d553a5483aafdc6e3a1c7d14", "reference_id": "ncb-scientific-1518a0abab435142", "scientific_core_sha256": "1483b6cdb989ba92276e8b50ab799aa326ff93b4ef3a6ecaddf6faf02d2e4284", "semantic_cluster_id": "ncb-sem-2b233c027e6c128b", "target_family": "asd", "task_ids": ["ncb21-task-7bc8d7047dac68a7"]}
{"aliases": ["psychosis_q046"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-172d75bcc17dcce9", "benchmark_track": "scientific", "claim_uid": "ncb-claim-b158ae5ae8b91424", "contract": {"claim_id": "psychosis_q046", "covariates": [], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across FBIRN_DISC and FBIRN_REP, is the SZ-versus-HC contrast for fc_mean_abs directionally consistent in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "172d75bcc17dcce9c2a8cde3b446b4521935e40d9bee3691b4d574e1b426012d", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "172d75bcc17dcce9c2a8cde3b446b4521935e40d9bee3691b4d574e1b426012d", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q046", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "Across FBIRN_DISC and FBIRN_REP, is the SZ-versus-HC contrast for fc_mean_abs directionally consistent in unadjusted dx-only comparisons with no covariates?", "question_sha256": "801d163072ac548006b03fd8eaa0ff97f01d380f90e7d7c5d906ac4deffc9b43", "reference_id": "ncb-scientific-172d75bcc17dcce9", "scientific_core_sha256": "68f3e3d6b4329417016b6e28cd3a86be4825bfc6d274d17e8ab55b07cb302b52", "semantic_cluster_id": "ncb-sem-b158ae5ae8b91424", "target_family": "psychosis", "task_ids": ["ncb21-task-c8829f53c8dd90c9"]}
{"aliases": ["ad_aging_q028"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-1775e0699f7d950f", "benchmark_track": "scientific", "claim_uid": "ncb-claim-1bd1a60a1440fb79", "contract": {"claim_id": "ad_aging_q028", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "smri_ventricles", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In OASIS3_DISC, among CN participants, is older age associated with higher smri_ventricles, adjusting for sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1775e0699f7d950fdfe70ffa2494b3427fbca176a2fb9bd01c5bf5329b7dd39e", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "1775e0699f7d950fdfe70ffa2494b3427fbca176a2fb9bd01c5bf5329b7dd39e", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q028", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In OASIS3_DISC, among CN participants, is older age associated with higher smri_ventricles, adjusting for sex?", "question_sha256": "7673d352e1390cc7192eb6c2ff946377a66e9b24a0fc99e47439342ab500e2f9", "reference_id": "ncb-scientific-1775e0699f7d950f", "scientific_core_sha256": "3871f231cdf9fbed5bf470b80b3da55f518a3e6ec860edfd1b78242a8189ac7e", "semantic_cluster_id": "ncb-sem-1bd1a60a1440fb79", "target_family": "ad_aging", "task_ids": ["ncb21-task-f6d996a2ba79a086"]}
{"aliases": ["adhd_q041"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-1954832d44d0ebd1", "benchmark_track": "scientific", "claim_uid": "ncb-claim-af493c396e1173da", "contract": {"claim_id": "adhd_q041", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered DorsalAttention-Visual connectivity (fc_fc_DorsAttn_Vis_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1954832d44d0ebd153d33a92a73ee22d02a964c7b8fcdadd30845d32219325eb", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "1954832d44d0ebd153d33a92a73ee22d02a964c7b8fcdadd30845d32219325eb", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q041", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered DorsalAttention-Visual connectivity (fc_fc_DorsAttn_Vis_z), with no additional covariates?", "question_sha256": "8bc529b5e9ad12fe39e7c2aac1e087d82346ebf78a63b62520fb568907a30ee9", "reference_id": "ncb-scientific-1954832d44d0ebd1", "scientific_core_sha256": "9965bbb5327fdf974600318a00f0d626e251b8be937e9feb802ca81a3ffe5989", "semantic_cluster_id": "ncb-sem-af493c396e1173da", "target_family": "adhd", "task_ids": ["ncb21-task-3b0e41e0dc79abef"]}
{"aliases": ["asd_q032"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-19802d4080b79f2e", "benchmark_track": "scientific", "claim_uid": "ncb-claim-ecf88ea9b21fc37a", "contract": {"claim_id": "asd_q032", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Limbic_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "19802d4080b79f2e8f176ede52b798824d854ec76cd44f5f03a2db90b40b33bc", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "19802d4080b79f2e8f176ede52b798824d854ec76cd44f5f03a2db90b40b33bc", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q032", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Limbic_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "f68ebdf86b61f4ddf03be5e934baa70b054571d6a60ef6106fab704fdce6791c", "reference_id": "ncb-scientific-19802d4080b79f2e", "scientific_core_sha256": "810e1165e4d755088cab4e0d38f247f63811b6c8a40ffd9ce8b003a9effe36b3", "semantic_cluster_id": "ncb-sem-ecf88ea9b21fc37a", "target_family": "asd", "task_ids": ["ncb21-task-f521adcc4c6f9c05"]}
{"aliases": ["ad_aging_q001", "ad_aging_q010"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-1b8a8b0d4ec2f528", "benchmark_track": "scientific", "claim_uid": "ncb-claim-d295d09b83e74459", "contract": {"claim_id": "ad_aging_q001", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_hippocampus", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with lower smri_hippocampus than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1b8a8b0d4ec2f5286857565cc3b20b69b0e31e8b7a6ef26b710a5387f2b28f93", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "1b8a8b0d4ec2f5286857565cc3b20b69b0e31e8b7a6ef26b710a5387f2b28f93", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q001", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}, {"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q010", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with lower smri_hippocampus than CN, adjusting for age and sex?", "question_sha256": "1504487b6b62f6f843c36f09dac3d721baac3e9b0d8f05b3f0e4d736f4ff2dd7", "reference_id": "ncb-scientific-1b8a8b0d4ec2f528", "scientific_core_sha256": "b3e19b2d6b453b9bd2df225b99dd31fb3f14519312f5f1d8b59832a9b8a4700b", "semantic_cluster_id": "ncb-sem-d295d09b83e74459", "target_family": "ad_aging", "task_ids": ["ncb21-task-fb4489244a478c3c"]}
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{"aliases": ["psychosis_q041"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-1d82194a9c52b4fa", "benchmark_track": "scientific", "claim_uid": "ncb-claim-f6629357fa60f0d6", "contract": {"claim_id": "psychosis_q041", "covariates": [], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ChineseSZ_DISC and ChineseSZ_REP, is the SZ-versus-HC contrast for fc_mean_positive directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["ChineseSZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1d82194a9c52b4fa5071ac4e2534c4dcf3c59a3ec7bc0186d85580ca6cd85358", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "1d82194a9c52b4fa5071ac4e2534c4dcf3c59a3ec7bc0186d85580ca6cd85358", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q041", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "Across ChineseSZ_DISC and ChineseSZ_REP, is the SZ-versus-HC contrast for fc_mean_positive directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "question_sha256": "867c969c3d97b711092991763d36949ea8dbefe84489dd86581ae4a78ea7f166", "reference_id": "ncb-scientific-1d82194a9c52b4fa", "scientific_core_sha256": "88fca814e931735a6e7b19bbb6f8273b6e490ca40544d48dfd429283bcbb7dae", "semantic_cluster_id": "ncb-sem-f6629357fa60f0d6", "target_family": "psychosis", "task_ids": ["ncb21-task-9051660984b1ecd9"]}
{"aliases": ["asd_q034"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-1f13a7aee9fc1c7d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-aad0f0b098d0ebad", "contract": {"claim_id": "asd_q034", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_SalVentAttn_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1f13a7aee9fc1c7dc1187efe86c3068be853653eb4050183fac5bcb492b8bbe3", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "1f13a7aee9fc1c7dc1187efe86c3068be853653eb4050183fac5bcb492b8bbe3", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q034", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_SalVentAttn_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "a7582fe59f3c1108a53f9b0392fd54e28cdc347df002104cb19fb7806e102792", "reference_id": "ncb-scientific-1f13a7aee9fc1c7d", "scientific_core_sha256": "5c76af45d23092631c50ee88c6fcd4b5d65aa5ec8d2737b6a44a22dd566283f5", "semantic_cluster_id": "ncb-sem-aad0f0b098d0ebad", "target_family": "asd", "task_ids": ["ncb21-task-0a70018376a8881b"]}
{"aliases": ["asd_q042"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-1f634e71dd689f9b", "benchmark_track": "scientific", "claim_uid": "ncb-claim-ff10f2963ca8353f", "contract": {"claim_id": "asd_q042", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Limbic_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Limbic_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1f634e71dd689f9bf628ab2462201c44d5996f29424ad3bb244eae08906e402b", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "1f634e71dd689f9bf628ab2462201c44d5996f29424ad3bb244eae08906e402b", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q042", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Limbic_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "56db717c9ee711689f24e42842466bbde7048f7ace307c60d095601ab786f3b4", "reference_id": "ncb-scientific-1f634e71dd689f9b", "scientific_core_sha256": "8df9db1c1f1f458cda7d70223932d137259e4ff86d92ce495b1047d2a9b51fb9", "semantic_cluster_id": "ncb-sem-ff10f2963ca8353f", "target_family": "asd", "task_ids": ["ncb21-task-3d093bb7bad5924a"]}
{"aliases": ["adhd_q026"], "alignment_disposition": "repairable_contract", "benchmark_case_id": "ncb-scientific-1f683beae6c7e55d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-9610f92c93cdb893", "contract": {"claim_id": "adhd_q026", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "1", "control": "0", "var": "dx"}, "outcome": "fc_fc_Cont_SalVentAttn_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, does ADHD-combined type (dx=1) versus control (dx=0) show altered Control-Salience/VentralAttention connectivity (fc_fc_Cont_SalVentAttn_z), with no additional covariates, and is the association replicated in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "19edb47c02cb0036902de8292dde8fb20838f917fb06cdbf7e5e5eba5b6d0add", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "1f683beae6c7e55d7bddcf82f4a7904b91a09d5c9ed58f28b3c66a3f9095c2e5", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q026", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, does ADHD-combined type (dx=1) versus control (dx=0) show altered Control-Salience/VentralAttention connectivity (fc_fc_Cont_SalVentAttn_z), with no additional covariates, and is the association replicated in ADHD200_REP?", "question_sha256": "ee2a6df5254c62baacc392591ef05884c78e53b28a133f5c94d9b2cdba1ed90d", "reference_id": "ncb-scientific-1f683beae6c7e55d", "scientific_core_sha256": "18d859f40fdf7646bee33474026662ecb765b06c6d476d0a7566991092f31018", "semantic_cluster_id": "ncb-sem-9610f92c93cdb893", "target_family": "adhd", "task_ids": ["ncb21-task-6c02f426814e0028"]}
{"aliases": ["fbirn_sz_cognition"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-1f9b7b9991250bd7", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a189ecfd7f696ffb", "contract": {"claim_id": "fbirn_sz_cognition", "covariates": ["age", "sex", "site"], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": "summary_fc", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For schizophrenia cognition anchor in psychosis, using FBIRN as discovery and COBRE/SZ_JH as replication, test the claim with expected direction two_sided and adjust for age;sex when available.", "replication_cohorts": ["COBRE_REP", "JH_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "preregistered"}}, "contract_sha256": "1f9b7b9991250bd79fc9033f2a5b7c572c78ef720a49515d03a284e3899b70d3", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "1f9b7b9991250bd79fc9033f2a5b7c572c78ef720a49515d03a284e3899b70d3", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "[VERIFY]", "source_collection": "legacy_scientific", "source_id": "fbirn_sz_cognition", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "psychosis"}], "question": "For schizophrenia cognition anchor in psychosis, using FBIRN as discovery and COBRE/SZ_JH as replication, test the claim with expected direction two_sided and adjust for age;sex when available.", "question_sha256": "9daf31b295166f85b24a8dd69d534c7b295991f845021cb2a8b9bc20394544fa", "reference_id": "ncb-scientific-1f9b7b9991250bd7", "scientific_core_sha256": "aa700b11ddda8dc831c0f750e917ea5144072f1c6043e2662d40dc08e051eb42", "semantic_cluster_id": "ncb-sem-a189ecfd7f696ffb", "target_family": "psychosis", "task_ids": ["ncb21-task-1cd56ef2b757f69d"]}
{"aliases": ["asd_q050"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-206dd8d45a4d9d89", "benchmark_track": "scientific", "claim_uid": "ncb-claim-b4a8d5bfb3357c42", "contract": {"claim_id": "asd_q050", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_SomMot_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "206dd8d45a4d9d891eb2644f5acdf1aeb9a4d894209c6c0c3142e2a74481d2e3", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "206dd8d45a4d9d891eb2644f5acdf1aeb9a4d894209c6c0c3142e2a74481d2e3", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q050", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_SomMot_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "9a8b3ada48613ae7ef76b281498919c153b6d6f8b7b95da20a56fc642bf02251", "reference_id": "ncb-scientific-206dd8d45a4d9d89", "scientific_core_sha256": "6154ed998fd488938d7d3abf13ad63488d92cef6d199bf24bb49ae449b341e3e", "semantic_cluster_id": "ncb-sem-b4a8d5bfb3357c42", "target_family": "asd", "task_ids": ["ncb21-task-a9bd3530545a0c3f"]}
{"aliases": ["ad_aging_q033"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-2290e2c4612f7606", "benchmark_track": "scientific", "claim_uid": "ncb-claim-35771173cccac1ce", "contract": {"claim_id": "ad_aging_q033", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_wholebrain", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In ADNI_DISC, among CN participants, is older age associated with lower smri_wholebrain, adjusting for sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2290e2c4612f7606a50c7a7de849ae8a00aa0d67c1cb0d41adda7d27c1cec0f3", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "2290e2c4612f7606a50c7a7de849ae8a00aa0d67c1cb0d41adda7d27c1cec0f3", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q033", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, among CN participants, is older age associated with lower smri_wholebrain, adjusting for sex?", "question_sha256": "25c46966a02fefcc882cd492f918798f98d9d71b135b2cc888744d40d8bc6252", "reference_id": "ncb-scientific-2290e2c4612f7606", "scientific_core_sha256": "715a652ee2118f7897596a57d5b11b6dcee84908159854c5ef9c6d9dae750dbe", "semantic_cluster_id": "ncb-sem-35771173cccac1ce", "target_family": "ad_aging", "task_ids": ["ncb21-task-a28ed8ee092fce61"]}
{"aliases": ["sex_smri_abcd_hcp"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-22dfa8274c94ef0c", "benchmark_track": "scientific", "claim_uid": "ncb-claim-20abebdf593c9583", "contract": {"claim_id": "sex_smri_abcd_hcp", "covariates": ["age", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For sex difference in eTIV-adjusted regional volume in sMRI, using ABCD as discovery and HCP as replication, test the claim with expected direction two_sided and adjust for age;eTIV;site required when available.", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "22dfa8274c94ef0ca691e86a84e9cb6284654e84187bed2471b78d817f606736", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "22dfa8274c94ef0ca691e86a84e9cb6284654e84187bed2471b78d817f606736", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Ritchie et al. 2018 Cerebral Cortex", "source_collection": "legacy_scientific", "source_id": "sex_smri_abcd_hcp", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "normative_fmri"}], "question": "For sex difference in eTIV-adjusted regional volume in sMRI, using ABCD as discovery and HCP as replication, test the claim with expected direction two_sided and adjust for age;eTIV;site required when available.", "question_sha256": "f8001f9638296fa035396584e9210d4a5da27ed329a22784386b2193305946b6", "reference_id": "ncb-scientific-22dfa8274c94ef0c", "scientific_core_sha256": "a99738add375cd15e91bbcf837d310c2195e1c4e458439a50eed7841a10f4a5a", "semantic_cluster_id": "ncb-sem-20abebdf593c9583", "target_family": "normative_fmri", "task_ids": []}
{"aliases": ["underpowered_adhd_site_adhd200"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-2387b1cf701bf90b", "benchmark_track": "scientific", "claim_uid": "ncb-claim-7ccfc692bc2f2980", "contract": {"claim_id": "underpowered_adhd_site_adhd200", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "functional_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ADHD small-sample fragile FC stress in fMRI-FC, using ADHD200 as discovery and ADHD200 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "2387b1cf701bf90b90bf70f3c5c04dbfec0b9625401e8f33be140f88ea2a6f70", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "2387b1cf701bf90b90bf70f3c5c04dbfec0b9625401e8f33be140f88ea2a6f70", "provenance": [{"prior_label": "fragile", "source_citation": "ADHD-200 Consortium 2012 [VERIFY]", "source_collection": "legacy_scientific", "source_id": "underpowered_adhd_site_adhd200", "source_mode": "inventory", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "adhd"}], "question": "For ADHD small-sample fragile FC stress in fMRI-FC, using ADHD200 as discovery and ADHD200 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "question_sha256": "052d4271cd94696fdf3be177c92ef98b16de9bc3d135bdacfb767bed7ea640a3", "reference_id": "ncb-scientific-2387b1cf701bf90b", "scientific_core_sha256": "eb70d794309c5a56346d53426e0ba6179eb188ff1fc747fc5489de6a35af45a6", "semantic_cluster_id": "ncb-sem-7ccfc692bc2f2980", "target_family": "adhd", "task_ids": ["ncb21-task-764317d4977b6d70"]}
{"aliases": ["psychosis_q030"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-23a83dcb8dd0287e", "benchmark_track": "scientific", "claim_uid": "ncb-claim-b158ae5ae8b91424", "contract": {"claim_id": "psychosis_q030", "covariates": [], "discovery_cohort": "FBIRN_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In FBIRN_REP, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted dx-only comparison with no covariates?", "replication_cohorts": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "23a83dcb8dd0287e82e81be378cb004bce79a5325cd73ba2c55edfee8113d52d", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "23a83dcb8dd0287e82e81be378cb004bce79a5325cd73ba2c55edfee8113d52d", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q030", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In FBIRN_REP, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted dx-only comparison with no covariates?", "question_sha256": "171a3cc3dbdf8c1b7c23a009735fbf4287cfb98beaf7f8702212c8a20b5ee413", "reference_id": "ncb-scientific-23a83dcb8dd0287e", "scientific_core_sha256": "b2745ce53c4e23c0e4ff789825737a4d51031543509f97fba574aec6415bc8b9", "semantic_cluster_id": "ncb-sem-b158ae5ae8b91424", "target_family": "psychosis", "task_ids": ["ncb21-task-9e6e0c742f90a6aa"]}
{"aliases": ["psychosis_q033"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-23b8d8c0265298fd", "benchmark_track": "scientific", "claim_uid": "ncb-claim-f6629357fa60f0d6", "contract": {"claim_id": "psychosis_q033", "covariates": [], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across BSNIP2_DISC and BSNIP2_REP, is the SZ-versus-HC contrast for fc_mean_positive directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "23b8d8c0265298fd242715da197614417003ea5efbb70bf6b292cb27ea990f0d", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "23b8d8c0265298fd242715da197614417003ea5efbb70bf6b292cb27ea990f0d", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q033", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "Across BSNIP2_DISC and BSNIP2_REP, is the SZ-versus-HC contrast for fc_mean_positive directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "question_sha256": "8ad7a82f158a2d7ce90d1f4b1e40fa635898ef732422facd8fee869099265a14", "reference_id": "ncb-scientific-23b8d8c0265298fd", "scientific_core_sha256": "7fedec7ed8e4dc3d05cd7dadb1c86170d525ed083ff3d48f470d3581a11a3a16", "semantic_cluster_id": "ncb-sem-f6629357fa60f0d6", "target_family": "psychosis", "task_ids": ["ncb21-task-e410009c1d1936d2"]}
{"aliases": ["adhd_q039"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-23d61a93cc5dbec1", "benchmark_track": "scientific", "claim_uid": "ncb-claim-ef2251f9690dfabc", "contract": {"claim_id": "adhd_q039", "covariates": [], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Limbic-Visual connectivity (fc_fc_Limbic_Vis_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "23d61a93cc5dbec1201748d85be106d526d3eb4bc7a44e09052d181d46ae110f", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "23d61a93cc5dbec1201748d85be106d526d3eb4bc7a44e09052d181d46ae110f", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q039", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Limbic-Visual connectivity (fc_fc_Limbic_Vis_z), with no additional covariates?", "question_sha256": "443dbcf9d09f16243dbaca1f851098003f4ae5640f251b4c1b5a0812be068eb3", "reference_id": "ncb-scientific-23d61a93cc5dbec1", "scientific_core_sha256": "c4b7c90df68fab68b74f9766d988c1577a56593f040d65224e3188511190504b", "semantic_cluster_id": "ncb-sem-ef2251f9690dfabc", "target_family": "adhd", "task_ids": ["ncb21-task-fd94e34ea1090527"]}
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{"aliases": ["pubmed_39013249_pmid39013249_age_ifg_vatl_semantic_fc"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-2aa338cf718c206f", "benchmark_track": "scientific", "claim_uid": "ncb-claim-af821d5180b2cebb", "contract": {"claim_id": "pubmed_39013249_pmid39013249_age_ifg_vatl_semantic_fc", "covariates": ["sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_", "predictor": "age", "region_set": "fMRI_functional_connectivity", "type": "association", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded age group or age, with young group compared against older participants effect on age moderation of semantic-network functional connectivity in fMRI-FC, using ABCD as discovery and HCP_Aging as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "2aa338cf718c206f1f58b7a786bbc5a49d2a0f094fde38b832b7d6280ab18b62", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "2aa338cf718c206f1f58b7a786bbc5a49d2a0f094fde38b832b7d6280ab18b62", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:39013249; DOI:10.1016/j.cortex.2024.06.015", "source_collection": "stage2_current", "source_id": "pubmed_39013249_pmid39013249_age_ifg_vatl_semantic_fc", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "For literature-grounded age group or age, with young group compared against older participants effect on age moderation of semantic-network functional connectivity in fMRI-FC, using ABCD as discovery and HCP_Aging as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "question_sha256": "01c2593771478f06c89a5b94078f54495faa6fdeea493d19aa9a9601a0a7e6f0", "reference_id": "ncb-scientific-2aa338cf718c206f", "scientific_core_sha256": "0d675772c5c9b60cb38690deb829660d3060ad6eb6690dae706f1c4433610741", "semantic_cluster_id": "ncb-sem-af821d5180b2cebb", "target_family": "normative_fmri", "task_ids": ["ncb21-task-cbc18e184afcce9b"]}
{"aliases": ["asd_q005"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-2aadc4e4de851c0e", "benchmark_track": "scientific", "claim_uid": "ncb-claim-bcd31e36404b748e", "contract": {"claim_id": "asd_q005", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_HOLDOUT", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_HOLDOUT, is fc_mean_abs lower in ASD than HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2aadc4e4de851c0e2f50ccae550c5f5b5318d46843b677d9fa6b9b8ee0ab5262", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "2aadc4e4de851c0e2f50ccae550c5f5b5318d46843b677d9fa6b9b8ee0ab5262", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q005", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE1_HOLDOUT, is fc_mean_abs lower in ASD than HC participants using dx as the predictor and no additional covariates?", "question_sha256": "f8e28f46161621085facc3c7bf340714e8f5bfc7229f2a8983b04278530a681d", "reference_id": "ncb-scientific-2aadc4e4de851c0e", "scientific_core_sha256": "bea818338f288e1e2e3be69ccef4d0d237cff3db3e178da086c96eef7ebb6394", "semantic_cluster_id": "ncb-sem-bcd31e36404b748e", "target_family": "asd", "task_ids": ["ncb21-task-a2c95f837064e61f"]}
{"aliases": ["adhd_q022"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-scientific-2b20954defb2352a", "benchmark_track": "scientific", "claim_uid": "ncb-claim-12dcb0029dea3ff4", "contract": {"claim_id": "adhd_q022", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_DorsAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, does ADHD-inattentive type (dx=2) versus control (dx=0) show lower Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z), with no additional covariates, and does this direction replicate in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2b20954defb2352adc7058f253db893e9e15a670abc51dcc80c24098106801e4", "migration_status": "non_executable", "modality": "fMRI-FC", "pre_v2_contract_sha256": "2b20954defb2352adc7058f253db893e9e15a670abc51dcc80c24098106801e4", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q022", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, does ADHD-inattentive type (dx=2) versus control (dx=0) show lower Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z), with no additional covariates, and does this direction replicate in ADHD200_REP?", "question_sha256": "ca3f560c7a0a50ccaaba1887b132b43d790be7c4e01a2d583b5c06a75f1ebdfd", "reference_id": "ncb-scientific-2b20954defb2352a", "scientific_core_sha256": "6bacdd5d43906b4ef27d5fcf7b9562e6390a568916d8158f37a028f772f8f041", "semantic_cluster_id": "ncb-sem-12dcb0029dea3ff4", "target_family": "adhd", "task_ids": []}
{"aliases": ["adhd_q006"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-2b36f4bbee998e56", "benchmark_track": "scientific", "claim_uid": "ncb-claim-d2bebe5a15f8a56a", "contract": {"claim_id": "adhd_q006", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with lower within-Control connectivity (fc_fc_Cont_Cont_z), with no additional covariates, and does the same direction replicate in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2b36f4bbee998e56371c67ff67d3eb58cb82ee7ec32ac324f688db7f55016f64", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "2b36f4bbee998e56371c67ff67d3eb58cb82ee7ec32ac324f688db7f55016f64", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q006", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with lower within-Control connectivity (fc_fc_Cont_Cont_z), with no additional covariates, and does the same direction replicate in ABCD_REP?", "question_sha256": "5935718036d1c3803e4f95351b8124975483e3e694e69b22c278f4379dd71738", "reference_id": "ncb-scientific-2b36f4bbee998e56", "scientific_core_sha256": "7b9eff43a99328328e33570cbe7321b82e129dfe5d9c6d6b0a4f2845fa24ce6a", "semantic_cluster_id": "ncb-sem-d2bebe5a15f8a56a", "target_family": "adhd", "task_ids": ["ncb21-task-60f7a3ceb0c0d995"]}
{"aliases": ["ad_aging_q024"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-2b8c1957240b2b85", "benchmark_track": "scientific", "claim_uid": "ncb-claim-1aa85065ed1b8153", "contract": {"claim_id": "ad_aging_q024", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_wholebrain", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with lower smri_wholebrain than CN, adjusting for age and sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2b8c1957240b2b852adfb606d88c4a9eec86d9078c3aac22a990d5bdbcd1b36c", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "2b8c1957240b2b852adfb606d88c4a9eec86d9078c3aac22a990d5bdbcd1b36c", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q024", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with lower smri_wholebrain than CN, adjusting for age and sex?", "question_sha256": "da3fc0b5a32c241d884eb531ccabf0d99b59db475b22234bbb2901c8d57ee28c", "reference_id": "ncb-scientific-2b8c1957240b2b85", "scientific_core_sha256": "4c359022a7d66ce9cf434b746f612f69f3d30de32a31ee2a01092a69063df95c", "semantic_cluster_id": "ncb-sem-1aa85065ed1b8153", "target_family": "ad_aging", "task_ids": ["ncb21-task-a9121137ac022382"]}
{"aliases": ["normative_fmri_004"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-2da7ae8514465754", "benchmark_track": "scientific", "claim_uid": "ncb-claim-056dec378820f0e1", "contract": {"claim_id": "normative_fmri_004", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with higher connectivity between the default-mode and dorsal-attention networks (fc_fc_Default_DorsAttn_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2da7ae8514465754088a9e1b59a38f021dec2a48c9ba27749492356ee704e952", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "2da7ae8514465754088a9e1b59a38f021dec2a48c9ba27749492356ee704e952", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_004", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with higher connectivity between the default-mode and dorsal-attention networks (fc_fc_Default_DorsAttn_z), adjusting for sex and cognition?", "question_sha256": "e901b905a0a8a04497a5aa6b51dc1ec627ded00b08b0dc9b702170661ed9e948", "reference_id": "ncb-scientific-2da7ae8514465754", "scientific_core_sha256": "f97719647507bc92d8ea51aa00b032788d435a2a086cbc109cecb5a36d9e53dd", "semantic_cluster_id": "ncb-sem-056dec378820f0e1", "target_family": "normative_fmri", "task_ids": ["ncb21-task-46aa865267479f06"]}
{"aliases": ["adhd_q028"], "alignment_disposition": "repairable_contract", "benchmark_case_id": "ncb-scientific-2dab47018aa41786", "benchmark_track": "scientific", "claim_uid": "ncb-claim-3a434f7a811e7a88", "contract": {"claim_id": "adhd_q028", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "3", "control": "0", "var": "dx"}, "outcome": "fc_fc_Cont_SomMot_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx in [\"0\", \"3\"]", "question": "In ADHD200_DISC, does ADHD-hyperactive/impulsive type (dx=3) versus control (dx=0) show altered Control-Somatomotor connectivity (fc_fc_Cont_SomMot_z), with no additional covariates, and is the same direction observed in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "716ac41c979ca4a5751727c9e8aca547707bebd52f5ebce962a7318706feddd3", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "2dab47018aa41786cae09c1b75eec5743001054db5b718ac2dcc5e8c57db09d5", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q028", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, does ADHD-hyperactive/impulsive type (dx=3) versus control (dx=0) show altered Control-Somatomotor connectivity (fc_fc_Cont_SomMot_z), with no additional covariates, and is the same direction observed in ADHD200_REP?", "question_sha256": "a86343caa5bb09eb59f77a3aa266fac7e2750127055bf382d2e6cc3ae5bace9c", "reference_id": "ncb-scientific-2dab47018aa41786", "scientific_core_sha256": "05420e04829a4c57c94596294d8a9197d86642557c05992503b632a44b64024a", "semantic_cluster_id": "ncb-sem-3a434f7a811e7a88", "target_family": "adhd", "task_ids": ["ncb21-task-5943e26730bd798a"]}
{"aliases": ["ad_aging_q035"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-2dcda273dbedc219", "benchmark_track": "scientific", "claim_uid": "ncb-claim-4bfef3e6f895651e", "contract": {"claim_id": "ad_aging_q035", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "pet_fdg_suvr", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In ADNI_DISC, among CN participants, is older age associated with lower pet_fdg_suvr, adjusting for sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2dcda273dbedc219ed9d5d8682aa85ac5f279a5b7efa0b335d1568599836b508", "migration_status": "ready", "modality": "PET", "pre_v2_contract_sha256": "2dcda273dbedc219ed9d5d8682aa85ac5f279a5b7efa0b335d1568599836b508", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q035", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, among CN participants, is older age associated with lower pet_fdg_suvr, adjusting for sex?", "question_sha256": "44bbbe483758003ad88a2ae6908f5a2e6f1ce531ef77a2cf316f851d302a6ae7", "reference_id": "ncb-scientific-2dcda273dbedc219", "scientific_core_sha256": "6400ad985c0db87a87969e031f38a853c617ca663f4f14bbf8b58c3c3bed7a69", "semantic_cluster_id": "ncb-sem-4bfef3e6f895651e", "target_family": "ad_aging", "task_ids": ["ncb21-task-d48e7b728a9c92fa"]}
{"aliases": ["normative_fmri_010"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-2ddc5b5c1ef8b93a", "benchmark_track": "scientific", "claim_uid": "ncb-claim-155bd22863afb6e2", "contract": {"claim_id": "normative_fmri_010", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_Limbic_Limbic_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with altered limbic within-network connectivity (fc_fc_Limbic_Limbic_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2ddc5b5c1ef8b93a0a9b11866e80d51afc5a4f22daaf095759d71baeefc4e50b", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "2ddc5b5c1ef8b93a0a9b11866e80d51afc5a4f22daaf095759d71baeefc4e50b", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_010", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with altered limbic within-network connectivity (fc_fc_Limbic_Limbic_z), adjusting for sex and cognition?", "question_sha256": "d95acff18dec0eb0cc02e157b5c1d9312cc99ab507e81acc1c62c9c5446cbd61", "reference_id": "ncb-scientific-2ddc5b5c1ef8b93a", "scientific_core_sha256": "5ed73df37eaa39c9cbcc584b4ef6d59899f34627341c72d82f1155e4e05cc134", "semantic_cluster_id": "ncb-sem-155bd22863afb6e2", "target_family": "normative_fmri", "task_ids": ["ncb21-task-e69cb146fb7350c6"]}
{"aliases": ["asd_q023"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-2e389c7806389508", "benchmark_track": "scientific", "claim_uid": "ncb-claim-bbeb196a4b73f672", "contract": {"claim_id": "asd_q023", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2e389c780638950829799320349d8009aea6c3e9e69be08b1982e12b5b434c52", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "2e389c780638950829799320349d8009aea6c3e9e69be08b1982e12b5b434c52", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q023", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "fefefcfb47a19cddc7e1c8d9a505edb76498995c8d7234c8be0d2612f7f85b96", "reference_id": "ncb-scientific-2e389c7806389508", "scientific_core_sha256": "f09200a182fcbc452b9265fe395f6be18cfd9cb6c3b6ec7a566a33fd78f4e050", "semantic_cluster_id": "ncb-sem-bbeb196a4b73f672", "target_family": "asd", "task_ids": ["ncb21-task-2256c13eb330feb3"]}
{"aliases": ["asd_q026"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-2f6ce6fa5ea95eeb", "benchmark_track": "scientific", "claim_uid": "ncb-claim-34c3c06b3308a06e", "contract": {"claim_id": "asd_q026", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_SalVentAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2f6ce6fa5ea95eeb785ac239b4ff56b118d9d5b5b0e1c76df4fda92bdb52f08c", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "2f6ce6fa5ea95eeb785ac239b4ff56b118d9d5b5b0e1c76df4fda92bdb52f08c", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q026", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "1cc181ed04ce94ae3a8a35cef9226410210ba71a00ccbecba42601ce195129e9", "reference_id": "ncb-scientific-2f6ce6fa5ea95eeb", "scientific_core_sha256": "54d4ece16eec4e787c8b8c66a96b963b0a5ca6a5fef506a99c232adfc0fef0ab", "semantic_cluster_id": "ncb-sem-34c3c06b3308a06e", "target_family": "asd", "task_ids": ["ncb21-task-c8004841f6d71d20"]}
{"aliases": ["adhd_q050"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-30329250c399e0e1", "benchmark_track": "scientific", "claim_uid": "ncb-claim-01b92be6f309d0ae", "contract": {"claim_id": "adhd_q050", "covariates": [], "discovery_cohort": "ABCD_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ABCD_REP and ADHD200_REP, using each cohort's available ADHD-control coding separately (ABCD dx=1.0 vs 0.0 excluding missing dx; ADHD200 dx in {1,2,3} vs 0), is the ADHD association with within-Default connectivity (fc_fc_Default_Default_z) directionally consistent, with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "30329250c399e0e19f0099ec82e0f1abd36cca45c0178fcdc6800cf75650db9e", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "30329250c399e0e19f0099ec82e0f1abd36cca45c0178fcdc6800cf75650db9e", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q050", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "Across ABCD_REP and ADHD200_REP, using each cohort's available ADHD-control coding separately (ABCD dx=1.0 vs 0.0 excluding missing dx; ADHD200 dx in {1,2,3} vs 0), is the ADHD association with within-Default connectivity (fc_fc_Default_Default_z) directionally consistent, with no additional covariates?", "question_sha256": "ad29c03c753cb54fc63c9e2bb9e55406d97ceb5211366e8a3fab4dbdf61828c4", "reference_id": "ncb-scientific-30329250c399e0e1", "scientific_core_sha256": "5deeec04029a5eef363857c98860bb794bc22a3e4c16594cf5a108d8aa6a88ae", "semantic_cluster_id": "ncb-sem-01b92be6f309d0ae", "target_family": "adhd", "task_ids": ["ncb21-task-4a3386676b1444ee"]}
{"aliases": ["asd_region_abide2_abcd"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-30a7ce77696eccff", "benchmark_track": "scientific", "claim_uid": "ncb-claim-909af75e142f1ce1", "contract": {"claim_id": "asd_region_abide2_abcd", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "functional_connectivity_network_pairs", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 28, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ASD case-control fMRI regional difference in fMRI-region, using ABIDE2 as discovery and ABCD as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 28, "selection": "preregistered"}}, "contract_sha256": "30a7ce77696eccffd0fadcf45c9e34ebb6e058cf0f57749c5a1f4fdca944a681", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "30a7ce77696eccffd0fadcf45c9e34ebb6e058cf0f57749c5a1f4fdca944a681", "provenance": [{"prior_label": "fragile", "source_citation": "Haar et al. 2016", "source_collection": "legacy_scientific", "source_id": "asd_region_abide2_abcd", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "asd"}], "question": "For ASD case-control fMRI regional difference in fMRI-region, using ABIDE2 as discovery and ABCD as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "question_sha256": "337ca8563ed7de13803ace320dcc42ba0147ff9ea5f53d87a1fae5441e27a864", "reference_id": "ncb-scientific-30a7ce77696eccff", "scientific_core_sha256": "2006bb692033df86e2570f546c489cb3a8dada025bdd9716b0e0ab063432331c", "semantic_cluster_id": "ncb-sem-909af75e142f1ce1", "target_family": "asd", "task_ids": []}
{"aliases": ["asd_q017"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-30f73b540a076be8", "benchmark_track": "scientific", "claim_uid": "ncb-claim-27d3f222f4588508", "contract": {"claim_id": "asd_q017", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "30f73b540a076be8877cbf58acf8e237d4ffaf8c5fa00b91f350eced56d4fe50", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "30f73b540a076be8877cbf58acf8e237d4ffaf8c5fa00b91f350eced56d4fe50", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q017", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "e0a1a693139df854df77ff104e7081d5c005c2a2154d6b8035a08cbf2efaa53e", "reference_id": "ncb-scientific-30f73b540a076be8", "scientific_core_sha256": "f4104e63d630e576877bbe4cee633b59f2b1f39689eb5e3f6f5386d6ec3f3058", "semantic_cluster_id": "ncb-sem-27d3f222f4588508", "target_family": "asd", "task_ids": ["ncb21-task-d75464cda8ffebe3"]}
{"aliases": ["asd_q025"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-31990e646f54d4e6", "benchmark_track": "scientific", "claim_uid": "ncb-claim-1caf036f3cfc92db", "contract": {"claim_id": "asd_q025", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_Limbic", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 1.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_Limbic differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "31990e646f54d4e694348212341524808d583a3747736b6aec3da643ffe1484e", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "31990e646f54d4e694348212341524808d583a3747736b6aec3da643ffe1484e", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q025", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_Limbic differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "1eb898e41a58e9b4e47896dc4fa553b65463e9ab42a8ddb8e9d8fe4712d6c7cb", "reference_id": "ncb-scientific-31990e646f54d4e6", "scientific_core_sha256": "3f03bcf22dcfa386a68ce52bc901336e31dc38d8fdbc95390bd6c1af52281d6a", "semantic_cluster_id": "ncb-sem-1caf036f3cfc92db", "target_family": "asd", "task_ids": ["ncb21-task-d1871ce3feb49f3f"]}
{"aliases": ["normative_fmri_047"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-319a1462bfdbc89d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-9d92911ddda7d4ee", "contract": {"claim_id": "normative_fmri_047", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "cohort in [\"HCP_DISC\", \"HCP_REP\"] or dx == \"0.0\"", "question": "Across ABCD_DISC and HCP_DISC, with replication in ABCD_REP and HCP_REP, is higher cognition associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and sex within each cohort and restricting ABCD to dx=0.0?", "replication_cohorts": ["HCP_DISC", "ABCD_REP", "HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "319a1462bfdbc89d930616a30480c076432748e170281465818679f30546de86", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "319a1462bfdbc89d930616a30480c076432748e170281465818679f30546de86", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_047", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "Across ABCD_DISC and HCP_DISC, with replication in ABCD_REP and HCP_REP, is higher cognition associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and sex within each cohort and restricting ABCD to dx=0.0?", "question_sha256": "6abc295941872d2b94bfd03c628b05449f0924fa3be230913bdcc5b77088a917", "reference_id": "ncb-scientific-319a1462bfdbc89d", "scientific_core_sha256": "5d791c868d0cb67c9971edee8b781f2cc7cd5796fe24a176782456f0da5a1ba7", "semantic_cluster_id": "ncb-sem-9d92911ddda7d4ee", "target_family": "normative_fmri", "task_ids": ["ncb21-task-22401568a4a4fe75"]}
{"aliases": ["asd_q006"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-31ff42faa1d10211", "benchmark_track": "scientific", "claim_uid": "ncb-claim-0de9c0c5b4d3defc", "contract": {"claim_id": "asd_q006", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_HOLDOUT", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_HOLDOUT, is fc_mean_positive lower in ASD than HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "31ff42faa1d102115303e78160cfa36a14361f7d5ebb5f9c28e43a81eac4e858", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "31ff42faa1d102115303e78160cfa36a14361f7d5ebb5f9c28e43a81eac4e858", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q006", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE1_HOLDOUT, is fc_mean_positive lower in ASD than HC participants using dx as the predictor and no additional covariates?", "question_sha256": "c830e5fb353698e8a17b0a32cab1bb7509963796b8a5ffc88905bb97f7be9a15", "reference_id": "ncb-scientific-31ff42faa1d10211", "scientific_core_sha256": "259cadae0fa2a80748b62769887a21528bb35ba10f7c9de0b7c829632b236c6c", "semantic_cluster_id": "ncb-sem-0de9c0c5b4d3defc", "target_family": "asd", "task_ids": ["ncb21-task-da20639354308cd3"]}
{"aliases": ["psychosis_q013"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-32c06a5e43e74faa", "benchmark_track": "scientific", "claim_uid": "ncb-claim-0de9c0c5b4d3defc", "contract": {"claim_id": "psychosis_q013", "covariates": ["age", "sex", "site"], "discovery_cohort": "COBRE_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_REP, is SZ associated with lower fc_mean_positive than HC in an unadjusted comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "32c06a5e43e74faa24d16e67accf4262d0369671f06216c693238d120d8f16f9", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "32c06a5e43e74faa24d16e67accf4262d0369671f06216c693238d120d8f16f9", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q013", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In COBRE_REP, is SZ associated with lower fc_mean_positive than HC in an unadjusted comparison using dx as the only predictor and no covariates?", "question_sha256": "32af0075f3b30c16797035845ea20ac9d213eae7c533b28921ea09373eab2c07", "reference_id": "ncb-scientific-32c06a5e43e74faa", "scientific_core_sha256": "cd5852946b1fb0165fd071056090b542c14f152976505671ed1a1350b0d90fd2", "semantic_cluster_id": "ncb-sem-0de9c0c5b4d3defc", "target_family": "psychosis", "task_ids": ["ncb21-task-a94f030e722dccd8"]}
{"aliases": ["ad_aging_q031"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-349eb82545a4fed6", "benchmark_track": "scientific", "claim_uid": "ncb-claim-7d72a72282bd75df", "contract": {"claim_id": "ad_aging_q031", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": ["smri_entorhinal", "smri_hippocampus", "smri_midtemp"], "predictor": "confirm_dx", "region_set": "temporal_lobe_structural_profile", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 3, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with a lower temporal-lobe structural profile, including smri_entorhinal, smri_hippocampus, and smri_midtemp, than CN, adjusting for age and sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 3, "selection": "preregistered"}}, "contract_sha256": "349eb82545a4fed6773d127ca9efbf6796bd4a270d60e579a6f05be27fdcc720", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "349eb82545a4fed6773d127ca9efbf6796bd4a270d60e579a6f05be27fdcc720", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q031", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with a lower temporal-lobe structural profile, including smri_entorhinal, smri_hippocampus, and smri_midtemp, than CN, adjusting for age and sex?", "question_sha256": "915fb0b02db7ed098d3e37be3496e609041a3d9bf49ea168def3180cd74387d7", "reference_id": "ncb-scientific-349eb82545a4fed6", "scientific_core_sha256": "4c5d876ae7e35fa769aa404c56fe4336038c76b027276f97c82585b3b066a750", "semantic_cluster_id": "ncb-sem-7d72a72282bd75df", "target_family": "ad_aging", "task_ids": ["ncb21-task-6e50e1fd75314a01"]}
{"aliases": ["ad_aging_q006"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-3578a76ed8bf3578", "benchmark_track": "scientific", "claim_uid": "ncb-claim-750f3d2e5a18f3fd", "contract": {"claim_id": "ad_aging_q006", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_fusiform", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with lower smri_fusiform than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3578a76ed8bf35781d498f17e97f52809043ab7d6566b7a2316e03be5b46504f", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "3578a76ed8bf35781d498f17e97f52809043ab7d6566b7a2316e03be5b46504f", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q006", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with lower smri_fusiform than CN, adjusting for age and sex?", "question_sha256": "2f6325a24e29ccb5dbac738603e08ff3b2edbca45205fd57e7b6cce8d1da9f03", "reference_id": "ncb-scientific-3578a76ed8bf3578", "scientific_core_sha256": "014895b946bf4421b4533b61fa55ab2a6e3cd1e8685cefbb66a842cf0e4de3a4", "semantic_cluster_id": "ncb-sem-750f3d2e5a18f3fd", "target_family": "ad_aging", "task_ids": ["ncb21-task-488d5612e99b3300"]}
{"aliases": ["normative_fmri_011"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-3700ad906c849ad5", "benchmark_track": "scientific", "claim_uid": "ncb-claim-e6626f0717ad07d0", "contract": {"claim_id": "normative_fmri_011", "covariates": ["age", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_Default_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, do females and males differ in default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for age and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3700ad906c849ad53fa7bd2bdd91cad428c07057952f31ecea37b17a562b5aa9", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "3700ad906c849ad53fa7bd2bdd91cad428c07057952f31ecea37b17a562b5aa9", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_011", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In UKB_DISC, with replication in UKB_REP, do females and males differ in default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for age and cognition?", "question_sha256": "dd0cec98d7f1aac97206ba48ff4eed4d194206d7740113afc245558505ea93be", "reference_id": "ncb-scientific-3700ad906c849ad5", "scientific_core_sha256": "4276cda719c93424930fcd08b892345fbeffe3719e3d6bded8ec4a3349d9f6a0", "semantic_cluster_id": "ncb-sem-e6626f0717ad07d0", "target_family": "normative_fmri", "task_ids": ["ncb21-task-33ad70367c5e5019"]}
{"aliases": ["psychosis_q023"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-3942bdaedf8efb2a", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2166e66544e56e96", "contract": {"claim_id": "psychosis_q023", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_REP, is fc_within_network lower in SZ than HC in an unadjusted dx-only group comparison with no covariates?", "replication_cohorts": ["ChineseSZ_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3942bdaedf8efb2afecb3c2c12045c0014df9f189b66d0de08e09298d10c22ae", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "3942bdaedf8efb2afecb3c2c12045c0014df9f189b66d0de08e09298d10c22ae", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q023", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In ChineseSZ_REP, is fc_within_network lower in SZ than HC in an unadjusted dx-only group comparison with no covariates?", "question_sha256": "45fc5a612e729a6508baf65d19a5bf36c2c8eb55cb58485f343c1b1eb135b55a", "reference_id": "ncb-scientific-3942bdaedf8efb2a", "scientific_core_sha256": "d34baf9839a1f7ce0351893f85dc9f2c76b5229d9fe60120e79e29850b5038af", "semantic_cluster_id": "ncb-sem-2166e66544e56e96", "target_family": "psychosis", "task_ids": ["ncb21-task-afd8d2f90a5decce"]}
{"aliases": ["asd_q014"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-3ad601039168835a", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a0c679d08f14f3e2", "contract": {"claim_id": "asd_q014", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Limbic", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Limbic differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3ad601039168835a0aa9153a5d2400c86e8ebb3edd86792e9be32f9545952cb0", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "3ad601039168835a0aa9153a5d2400c86e8ebb3edd86792e9be32f9545952cb0", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q014", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Limbic differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "c1631bb846f6bf6561333f590d5d585cc0e8358de76834da91d4c259aab0ab3c", "reference_id": "ncb-scientific-3ad601039168835a", "scientific_core_sha256": "fab86d965e8db8de8f66fd3c06297e5c8866a6fe6729d08baeba7f41f789ba65", "semantic_cluster_id": "ncb-sem-a0c679d08f14f3e2", "target_family": "asd", "task_ids": ["ncb21-task-63dee284104791ed"]}
{"aliases": ["psychosis_q037"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-3b7b2226aa3bb7ce", "benchmark_track": "scientific", "claim_uid": "ncb-claim-f6629357fa60f0d6", "contract": {"claim_id": "psychosis_q037", "covariates": [], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across COBRE_DISC and COBRE_REP, is the SZ-versus-HC contrast for fc_mean_positive directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3b7b2226aa3bb7ce109fe00563be869699e1fef55876cce35355c6941ea873fd", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "3b7b2226aa3bb7ce109fe00563be869699e1fef55876cce35355c6941ea873fd", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q037", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "Across COBRE_DISC and COBRE_REP, is the SZ-versus-HC contrast for fc_mean_positive directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "question_sha256": "f5236c2601228ac2c832ffccde7d04cf3fcd539b46b6cdb58110e4d691b59fe1", "reference_id": "ncb-scientific-3b7b2226aa3bb7ce", "scientific_core_sha256": "ac70bce3d42e2d481a168b4cc4a38a084461f508c36b13dda92fc5ee467f15fd", "semantic_cluster_id": "ncb-sem-f6629357fa60f0d6", "target_family": "psychosis", "task_ids": ["ncb21-task-dab97b669594593b"]}
{"aliases": ["asd_q030"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-3ba54e0248b29adb", "benchmark_track": "scientific", "claim_uid": "ncb-claim-ffd2364f0be169e2", "contract": {"claim_id": "asd_q030", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_SalVentAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Limbic_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3ba54e0248b29adb223a15306b37f76fc0e2b932fed74e86bd845de4c1fb2ee8", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "3ba54e0248b29adb223a15306b37f76fc0e2b932fed74e86bd845de4c1fb2ee8", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q030", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Limbic_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "f457824aa9838d8a64dbad1840052b2af6b449c8a3de005af65756ab4bb14f6a", "reference_id": "ncb-scientific-3ba54e0248b29adb", "scientific_core_sha256": "eb87f9570188517daaae7d91022e5fc26302a3db081ce8d96b2880bb1e6bf71e", "semantic_cluster_id": "ncb-sem-ffd2364f0be169e2", "target_family": "asd", "task_ids": ["ncb21-task-0d6282b64ac621ac"]}
{"aliases": ["asd_q039"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-3bb5fd92cff87e34", "benchmark_track": "scientific", "claim_uid": "ncb-claim-f1008f8ce10847e7", "contract": {"claim_id": "asd_q039", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Cont_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3bb5fd92cff87e343d33e2cd0d6797eaf54d41cfe43a2123a8f42229247ead6c", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "3bb5fd92cff87e343d33e2cd0d6797eaf54d41cfe43a2123a8f42229247ead6c", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q039", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Cont_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "3216377109631cb3e8700e5ef4e7b61b453b37799de22d813c5e133b043e979f", "reference_id": "ncb-scientific-3bb5fd92cff87e34", "scientific_core_sha256": "555008a59e88bc9bcd4c307543efe03626eadc2c7812cd3b22a23248c5c0b1a2", "semantic_cluster_id": "ncb-sem-f1008f8ce10847e7", "target_family": "asd", "task_ids": ["ncb21-task-b56a70f7ddd5fc44"]}
{"aliases": ["psychosis_q004"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-3cd280f660dfbcd4", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a44d2718db4923a4", "contract": {"claim_id": "psychosis_q004", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_DISC, do SZ and HC participants differ in fc_between_network in an unadjusted group comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3cd280f660dfbcd415a0ac5f54af96f2ce8fe1cc897a4a14f869e1ea54467213", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "3cd280f660dfbcd415a0ac5f54af96f2ce8fe1cc897a4a14f869e1ea54467213", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q004", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In BSNIP2_DISC, do SZ and HC participants differ in fc_between_network in an unadjusted group comparison using dx as the only predictor and no covariates?", "question_sha256": "0960ebd7c899621d0dff9af5d9c0b550295e3b9d0284eb626fb35be6b52689de", "reference_id": "ncb-scientific-3cd280f660dfbcd4", "scientific_core_sha256": "f555ea3e77e68e7c98be57a506ff641953f2f8e879082a91e5d6b59613b497bb", "semantic_cluster_id": "ncb-sem-a44d2718db4923a4", "target_family": "psychosis", "task_ids": ["ncb21-task-b93848fb1885ade6"]}
{"aliases": ["asd_q001"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-3e1160c83f5950a6", "benchmark_track": "scientific", "claim_uid": "ncb-claim-bcd31e36404b748e", "contract": {"claim_id": "asd_q001", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_DISC, with replication assessed in ABIDE1_REP, is fc_mean_abs lower in ASD than HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3e1160c83f5950a67cb5f0bbc0478fdf9f1049f9a00563f8ba1bc631c90a9dbf", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "3e1160c83f5950a67cb5f0bbc0478fdf9f1049f9a00563f8ba1bc631c90a9dbf", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q001", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE1_DISC, with replication assessed in ABIDE1_REP, is fc_mean_abs lower in ASD than HC participants using dx as the predictor and no additional covariates?", "question_sha256": "0a75415b4c04408e34290566724e63c7ba3987886fd331f3408c5bf65eb33b4c", "reference_id": "ncb-scientific-3e1160c83f5950a6", "scientific_core_sha256": "9469521d14c3659d1013228401e75bf62c0d991f15ab65567cfcfde3211aeaee", "semantic_cluster_id": "ncb-sem-bcd31e36404b748e", "target_family": "asd", "task_ids": ["ncb21-task-2aa14ad4c6a4579e"]}
{"aliases": ["psychosis_q043"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-41408a5127ecaa01", "benchmark_track": "scientific", "claim_uid": "ncb-claim-6c35024a79091cc0", "contract": {"claim_id": "psychosis_q043", "covariates": [], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ChineseSZ_DISC and ChineseSZ_REP, is the SZ-versus-HC contrast for fc_within_network directionally consistent with lower values in SZ in unadjusted dx-only group comparisons with no covariates?", "replication_cohorts": ["ChineseSZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "41408a5127ecaa01bb16f33bb137977cb589300803b75207c17804f34de42e00", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "41408a5127ecaa01bb16f33bb137977cb589300803b75207c17804f34de42e00", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q043", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "Across ChineseSZ_DISC and ChineseSZ_REP, is the SZ-versus-HC contrast for fc_within_network directionally consistent with lower values in SZ in unadjusted dx-only group comparisons with no covariates?", "question_sha256": "acd99d52fb45c9fbec061999b8946a1c463eed51edefb93a00c1300d54610bc2", "reference_id": "ncb-scientific-41408a5127ecaa01", "scientific_core_sha256": "d3617af993f9850718a5ecaf13969aed2425799aba29739fcd97a43f5a296c7d", "semantic_cluster_id": "ncb-sem-6c35024a79091cc0", "target_family": "psychosis", "task_ids": ["ncb21-task-be3fb7338da2dc8b"]}
{"aliases": ["adhd_q049"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-41e14c6dd1c2213b", "benchmark_track": "scientific", "claim_uid": "ncb-claim-9afa33f4c5eb06ba", "contract": {"claim_id": "adhd_q049", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ABCD_DISC and ADHD200_DISC, using each cohort's available ADHD-control coding separately (ABCD dx=1.0 vs 0.0 excluding missing dx; ADHD200 dx in {1,2,3} vs 0), is the ADHD association with Salience/VentralAttention-Somatomotor connectivity (fc_fc_SalVentAttn_SomMot_z) in the same direction, with no additional covariates?", "replication_cohorts": ["ADHD200_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "41e14c6dd1c2213b09c65b85fb99ab48160786245ae19fcdf1dbe6c8a7704fe3", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "41e14c6dd1c2213b09c65b85fb99ab48160786245ae19fcdf1dbe6c8a7704fe3", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q049", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "Across ABCD_DISC and ADHD200_DISC, using each cohort's available ADHD-control coding separately (ABCD dx=1.0 vs 0.0 excluding missing dx; ADHD200 dx in {1,2,3} vs 0), is the ADHD association with Salience/VentralAttention-Somatomotor connectivity (fc_fc_SalVentAttn_SomMot_z) in the same direction, with no additional covariates?", "question_sha256": "23a368ff60828e0ee0db8a67512b99e21274ca785f78e54e5a323fc5016e3be0", "reference_id": "ncb-scientific-41e14c6dd1c2213b", "scientific_core_sha256": "c4867377c24ee0fa3f3e85e6d399d03d4d0faac735bd27d424027901e88f1984", "semantic_cluster_id": "ncb-sem-9afa33f4c5eb06ba", "target_family": "adhd", "task_ids": ["ncb21-task-1fa31ad921dc7522"]}
{"aliases": ["normative_fmri_037"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-424e2babe414b942", "benchmark_track": "scientific", "claim_uid": "ncb-claim-60a37008054031e7", "contract": {"claim_id": "normative_fmri_037", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher cognition associated with lower default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for age and sex?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "424e2babe414b942c9de6cea445152da63bc02ae3d4a57cba78750f02b7f0960", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "424e2babe414b942c9de6cea445152da63bc02ae3d4a57cba78750f02b7f0960", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_037", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher cognition associated with lower default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for age and sex?", "question_sha256": "c4847cc9ba269eec2b09c8947c21b8ce2ed072cb78d3d482e5b2b258471e8692", "reference_id": "ncb-scientific-424e2babe414b942", "scientific_core_sha256": "320bceb7128a61025172835c2cec6a45abce4da6d7bfb313cc492aa8fb944e6f", "semantic_cluster_id": "ncb-sem-60a37008054031e7", "target_family": "normative_fmri", "task_ids": ["ncb21-task-29ede93d8ab1d56d"]}
{"aliases": ["normative_fmri_006"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-42b2c11ed186c2c9", "benchmark_track": "scientific", "claim_uid": "ncb-claim-7da5c992c2ef34ed", "contract": {"claim_id": "normative_fmri_006", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Vis_Vis_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower visual-network within-network connectivity (fc_fc_Vis_Vis_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "42b2c11ed186c2c9d794dfd42e14b54cf31afc8d70f2f8c136913760977724fb", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "42b2c11ed186c2c9d794dfd42e14b54cf31afc8d70f2f8c136913760977724fb", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_006", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower visual-network within-network connectivity (fc_fc_Vis_Vis_z), adjusting for sex and cognition?", "question_sha256": "00fd057640d4e21c3977da61b48d58c502b5a2a71d27ad9a44b09795174e6371", "reference_id": "ncb-scientific-42b2c11ed186c2c9", "scientific_core_sha256": "15bc296126f81e5125c49daafa677a68730aed5eb7ee8ac4a807083d818e2788", "semantic_cluster_id": "ncb-sem-7da5c992c2ef34ed", "target_family": "normative_fmri", "task_ids": ["ncb21-task-24a9f287d05f4f0c"]}
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{"aliases": ["normative_fmri_020"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-456c48345929eb71", "benchmark_track": "scientific", "claim_uid": "ncb-claim-4baa47ead031cd94", "contract": {"claim_id": "normative_fmri_020", "covariates": ["age", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_SomMot_SomMot_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, do females and males differ in somatomotor within-network connectivity (fc_fc_SomMot_SomMot_z), adjusting for age and cognition?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "456c48345929eb71ad0b3a52855e1c8ae6d77f6e6ac96e12dc58ebe0ecd43705", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "456c48345929eb71ad0b3a52855e1c8ae6d77f6e6ac96e12dc58ebe0ecd43705", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_020", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In HCP_DISC, with replication in HCP_REP, do females and males differ in somatomotor within-network connectivity (fc_fc_SomMot_SomMot_z), adjusting for age and cognition?", "question_sha256": "18d607e826ddb60b2ac1b306496243e0e6b99d75c58f65c3f2eee46d3189eec2", "reference_id": "ncb-scientific-456c48345929eb71", "scientific_core_sha256": "9fbd80f0dfe16264f74d4785f4f0d8515c9b75c703c0bef523e380b28442c67f", "semantic_cluster_id": "ncb-sem-4baa47ead031cd94", "target_family": "normative_fmri", "task_ids": ["ncb21-task-9b8b8215a1ce887d"]}
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{"aliases": ["psychosis_q006"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-58864dfe748ed623", "benchmark_track": "scientific", "claim_uid": "ncb-claim-893ac2c9b485762f", "contract": {"claim_id": "psychosis_q006", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_REP, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "58864dfe748ed623b1e412e518eb6d075f1280ebe036bb1dc55e56e8a2aca169", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "58864dfe748ed623b1e412e518eb6d075f1280ebe036bb1dc55e56e8a2aca169", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q006", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In BSNIP2_REP, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted comparison using dx as the only predictor and no covariates?", "question_sha256": "314e17bed9a866bce881846048b0dc2e2b32f53a9fbb3a608a0e813c19888d20", "reference_id": "ncb-scientific-58864dfe748ed623", "scientific_core_sha256": "316d36f4ebdabf24d62c16f1e9ab6f02b8445d95f78aea91a0c4bf3eaba6af98", "semantic_cluster_id": "ncb-sem-893ac2c9b485762f", "target_family": "psychosis", "task_ids": ["ncb21-task-eba5de2aec72a501"]}
{"aliases": ["psychosis_q047"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-58a996a383e72e5b", "benchmark_track": "scientific", "claim_uid": "ncb-claim-6c35024a79091cc0", "contract": {"claim_id": "psychosis_q047", "covariates": [], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across FBIRN_DISC and FBIRN_REP, is the SZ-versus-HC contrast for fc_within_network directionally consistent with lower values in SZ in unadjusted comparisons using dx only and no covariates?", "replication_cohorts": ["FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "58a996a383e72e5b79cc802cd41cc61d146ef74faab2650d92112acd832924d8", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "58a996a383e72e5b79cc802cd41cc61d146ef74faab2650d92112acd832924d8", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q047", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "Across FBIRN_DISC and FBIRN_REP, is the SZ-versus-HC contrast for fc_within_network directionally consistent with lower values in SZ in unadjusted comparisons using dx only and no covariates?", "question_sha256": "23e96735ff84a2c582ee4808186ca51b89521482d6ce90dbeda6380ce319d331", "reference_id": "ncb-scientific-58a996a383e72e5b", "scientific_core_sha256": "11cb39da8a64e2be9e6096cba334e0ce56565619423b10be8e5cc6fdae7fca4b", "semantic_cluster_id": "ncb-sem-6c35024a79091cc0", "target_family": "psychosis", "task_ids": ["ncb21-task-db5dda410f80460c"]}
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{"aliases": ["adhd_q036"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-5af5c999c214ab93", "benchmark_track": "scientific", "claim_uid": "ncb-claim-0a4ed7bf61f20cb0", "contract": {"claim_id": "adhd_q036", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Vis_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered within-Visual connectivity (fc_fc_Vis_Vis_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5af5c999c214ab9372f9f2d8ade3dd6da56394efb2231c76129e7a21833959ea", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "5af5c999c214ab9372f9f2d8ade3dd6da56394efb2231c76129e7a21833959ea", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q036", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered within-Visual connectivity (fc_fc_Vis_Vis_z), with no additional covariates?", "question_sha256": "ccf4099ad8b6609ff96a20fdbbcbff59e776a091fb1a0aa0cfb687df1d3bfa79", "reference_id": "ncb-scientific-5af5c999c214ab93", "scientific_core_sha256": "70d5fa4400acc285f2f676ef2e4b905e33e62f4ed6023ddd94c0032901dd746a", "semantic_cluster_id": "ncb-sem-0a4ed7bf61f20cb0", "target_family": "adhd", "task_ids": ["ncb21-task-1a1dd6d309bd7a8a"]}
{"aliases": ["adhd_q010"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-5b0717b45335d600", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a8f42f69ec837949", "contract": {"claim_id": "adhd_q010", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SomMot_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "confirm_dx in [\"case\", \"control\"]", "question": "In ABCD_DISC, excluding missing dx, do ADHD cases (dx=1.0) show higher Visual-Somatomotor connectivity (fc_fc_SomMot_Vis_z) than controls (dx=0.0), with no additional covariates, and is the direction consistent in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5b0717b45335d600cb9bb3a3365f50480541f74ab04b95723d2b163524b995c2", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "5b0717b45335d600cb9bb3a3365f50480541f74ab04b95723d2b163524b995c2", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q010", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC, excluding missing dx, do ADHD cases (dx=1.0) show higher Visual-Somatomotor connectivity (fc_fc_SomMot_Vis_z) than controls (dx=0.0), with no additional covariates, and is the direction consistent in ABCD_REP?", "question_sha256": "6b5bdc4dddbee3b792e9544c0d98105f01a2b90cb96925c69cbebf7cafd9626f", "reference_id": "ncb-scientific-5b0717b45335d600", "scientific_core_sha256": "f1668e2649063716355784a7471b7346154ae8d358180e7a5804c681aebb6cad", "semantic_cluster_id": "ncb-sem-a8f42f69ec837949", "target_family": "adhd", "task_ids": ["ncb21-task-b8602e973f42b46b"]}
{"aliases": ["brainwide_adni_oasis_ad_signature"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-5b85792fec387f31", "benchmark_track": "scientific", "claim_uid": "ncb-claim-08d0dc1bbf33d0ab", "contract": {"claim_id": "brainwide_adni_oasis_ad_signature", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_", "predictor": "confirm_dx", "region_set": "ad_smri_regional_atrophy_signature", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 6, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For AD regional atrophy signature in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5b85792fec387f3151f93502d6b27218fa819acbbcdeeda46e7331b03e8d9f24", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "5b85792fec387f3151f93502d6b27218fa819acbbcdeeda46e7331b03e8d9f24", "provenance": [{"prior_label": "known_positive", "source_citation": "Jack et al. 2018 NIA-AA framework", "source_collection": "legacy_scientific", "source_id": "brainwide_adni_oasis_ad_signature", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "normative_fmri"}], "question": "For AD regional atrophy signature in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "question_sha256": "97be5076603be9d917c886dc45ede9e795636baad44684b76a809bc66b0edc5c", "reference_id": "ncb-scientific-5b85792fec387f31", "scientific_core_sha256": "7a8f870051ec1b9747c9c3d560ae91f103f54161c503996539bd0ec5d0774c80", "semantic_cluster_id": "ncb-sem-08d0dc1bbf33d0ab", "target_family": "normative_fmri", "task_ids": ["ncb21-task-61e7a78710d971c6"]}
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{"aliases": ["asd_q047"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-5d4734ea98c9d333", "benchmark_track": "scientific", "claim_uid": "ncb-claim-c3d285b10c7a0e2f", "contract": {"claim_id": "asd_q047", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_DorsAttn_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5d4734ea98c9d333507a8f256c939d4c32820705161302d7f9b6dece95787e70", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "5d4734ea98c9d333507a8f256c939d4c32820705161302d7f9b6dece95787e70", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q047", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_DorsAttn_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "e0532ef3d83af02c4b647c4e7dd24b14da5fa4f67b4c8228773cb5ba9bf556ff", "reference_id": "ncb-scientific-5d4734ea98c9d333", "scientific_core_sha256": "a39f3a02eebe062c2ff4dac382f74ecb609e2c30755e1a7a57d821fb10c8d871", "semantic_cluster_id": "ncb-sem-c3d285b10c7a0e2f", "target_family": "asd", "task_ids": ["ncb21-task-c1d31cf0f21d21b0"]}
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{"aliases": ["asd_q021"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-5e6aa7181e35b605", "benchmark_track": "scientific", "claim_uid": "ncb-claim-77e0b8089e3a4a66", "contract": {"claim_id": "asd_q021", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SalVentAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5e6aa7181e35b6057dcfa0b2ef30e1accaf27ffa30c7110a71e05a7d42cd2bf4", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "5e6aa7181e35b6057dcfa0b2ef30e1accaf27ffa30c7110a71e05a7d42cd2bf4", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q021", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "9dbb04d49595ab31799f0dff4ca9d3191283f2fe277327880665d6e8e5da2ea7", "reference_id": "ncb-scientific-5e6aa7181e35b605", "scientific_core_sha256": "2c09d04c1120857aecd0dcb6e15970743a11a4da5e328c593d3c4e7928ffd244", "semantic_cluster_id": "ncb-sem-77e0b8089e3a4a66", "target_family": "asd", "task_ids": ["ncb21-task-a18bfcd804ec2d1e"]}
{"aliases": ["psychosis_q008"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-5e9d9106292eb159", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a44d2718db4923a4", "contract": {"claim_id": "psychosis_q008", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_REP, do SZ and HC groups differ in fc_between_network in an unadjusted dx-only comparison with no covariates?", "replication_cohorts": ["Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5e9d9106292eb159971d41de9ac66f7064ff9c67b369099bff308886a86ec58b", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "5e9d9106292eb159971d41de9ac66f7064ff9c67b369099bff308886a86ec58b", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q008", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In BSNIP2_REP, do SZ and HC groups differ in fc_between_network in an unadjusted dx-only comparison with no covariates?", "question_sha256": "539b160493847b933e8d92aaf045515cc705c8b11a9796de97cf167c53cba37d", "reference_id": "ncb-scientific-5e9d9106292eb159", "scientific_core_sha256": "298e9158fa037cf9e1e95471f0ab0f7d06eb5bc02db17c8a87a48d226a8bacd1", "semantic_cluster_id": "ncb-sem-a44d2718db4923a4", "target_family": "psychosis", "task_ids": ["ncb21-task-9de8790b14dd8e89"]}
{"aliases": ["psychosis_q044"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-60bd3b9afd76e376", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2ccad72c3141229c", "contract": {"claim_id": "psychosis_q044", "covariates": [], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ChineseSZ_DISC and ChineseSZ_REP, is the SZ-versus-HC contrast for fc_between_network directionally consistent in unadjusted comparisons with dx as the only predictor and no covariates?", "replication_cohorts": ["ChineseSZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "60bd3b9afd76e37677bdfbacb0a6c8d31b310fd8b253df9b469f8298452d68fa", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "60bd3b9afd76e37677bdfbacb0a6c8d31b310fd8b253df9b469f8298452d68fa", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q044", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "Across ChineseSZ_DISC and ChineseSZ_REP, is the SZ-versus-HC contrast for fc_between_network directionally consistent in unadjusted comparisons with dx as the only predictor and no covariates?", "question_sha256": "be6b3e914569ab0930ffb0039689950636d0eb0c51e649d0493511c4b72ad7cd", "reference_id": "ncb-scientific-60bd3b9afd76e376", "scientific_core_sha256": "fb5490c0f9830bab67ec304a1909322e1353331b5565a5c9acb64000b9de418d", "semantic_cluster_id": "ncb-sem-2ccad72c3141229c", "target_family": "psychosis", "task_ids": ["ncb21-task-5bce015b2edbdfbc"]}
{"aliases": ["psychosis_q031"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-611e67de29172a34", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2166e66544e56e96", "contract": {"claim_id": "psychosis_q031", "covariates": ["age", "sex", "site"], "discovery_cohort": "FBIRN_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In FBIRN_REP, is fc_within_network lower in SZ than HC in an unadjusted group comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "611e67de29172a34127865843ed7fbb0a3c674cbea476eacda530d3d8c5a9abf", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "611e67de29172a34127865843ed7fbb0a3c674cbea476eacda530d3d8c5a9abf", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q031", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In FBIRN_REP, is fc_within_network lower in SZ than HC in an unadjusted group comparison with dx as the only predictor and no covariates?", "question_sha256": "83f61ceb13a1f77475c2bafa9ca9a6ce4041c1d2c98a28e1cd7fd503422ef111", "reference_id": "ncb-scientific-611e67de29172a34", "scientific_core_sha256": "fed36af8583bc05b8a84fd38a7299acbb0033fe255d20701d5a660daacef9695", "semantic_cluster_id": "ncb-sem-2166e66544e56e96", "target_family": "psychosis", "task_ids": ["ncb21-task-c2e929cb5553adf2"]}
{"aliases": ["asd_q036"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-61274f38e0112edd", "benchmark_track": "scientific", "claim_uid": "ncb-claim-11b4ebf49e0a3c2a", "contract": {"claim_id": "asd_q036", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SomMot_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_SomMot_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "61274f38e0112edde8180b2b74bd970e73a3a503b87528dec8547ff8d39e08d3", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "61274f38e0112edde8180b2b74bd970e73a3a503b87528dec8547ff8d39e08d3", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q036", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_SomMot_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "535c84f3611c6ee5e986210892b96d640bef5506a5df6811d8df0c847b6c21b5", "reference_id": "ncb-scientific-61274f38e0112edd", "scientific_core_sha256": "60d0918cd31da445f4f6856485f84fa783456f574180a65bcecc0296786ee0e8", "semantic_cluster_id": "ncb-sem-11b4ebf49e0a3c2a", "target_family": "asd", "task_ids": ["ncb21-task-121e269865518790"]}
{"aliases": ["psychosis_q028"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-6130b7ec9d114c16", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2ccad72c3141229c", "contract": {"claim_id": "psychosis_q028", "covariates": [], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In FBIRN_DISC, do SZ and HC participants differ in fc_between_network in an unadjusted dx-only group comparison with no covariates?", "replication_cohorts": ["FBIRN_REP", "BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6130b7ec9d114c162d53c779a173cc930024074dfc2f729afa0cd4fc7c5e3827", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "6130b7ec9d114c162d53c779a173cc930024074dfc2f729afa0cd4fc7c5e3827", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q028", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In FBIRN_DISC, do SZ and HC participants differ in fc_between_network in an unadjusted dx-only group comparison with no covariates?", "question_sha256": "d40b471f39d3f359ec9a43c6dbba7db2c2ecbf620038ab06d3d5c2d59be6edcc", "reference_id": "ncb-scientific-6130b7ec9d114c16", "scientific_core_sha256": "d5f7a148dbdb909ed1e20a8310ac007e878cf9b8f3d35a9774bc0ff4f207043f", "semantic_cluster_id": "ncb-sem-2ccad72c3141229c", "target_family": "psychosis", "task_ids": ["ncb21-task-be735a5c5e04df19"]}
{"aliases": ["psychosis_q015"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-622e97baf8eece3c", "benchmark_track": "scientific", "claim_uid": "ncb-claim-6c35024a79091cc0", "contract": {"claim_id": "psychosis_q015", "covariates": [], "discovery_cohort": "COBRE_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_REP, is fc_within_network lower in SZ than HC in an unadjusted dx-only comparison with no covariates?", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "622e97baf8eece3cc6a62615addca82592c24a5eb42cd164d81459a0d041eaab", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "622e97baf8eece3cc6a62615addca82592c24a5eb42cd164d81459a0d041eaab", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q015", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In COBRE_REP, is fc_within_network lower in SZ than HC in an unadjusted dx-only comparison with no covariates?", "question_sha256": "cd3601dfd0043d88bca145b4600da4e750740d909e5ebba12c6d2b4749b0d7ae", "reference_id": "ncb-scientific-622e97baf8eece3c", "scientific_core_sha256": "a626fe8c7acf49642db12b8ed6ac78e955ad07b699f245210ab49bc66f6666a5", "semantic_cluster_id": "ncb-sem-6c35024a79091cc0", "target_family": "psychosis", "task_ids": ["ncb21-task-fee6640bb16b3dd4"]}
{"aliases": ["adhd_q037"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-629feeb21e3e9864", "benchmark_track": "scientific", "claim_uid": "ncb-claim-ff10f2963ca8353f", "contract": {"claim_id": "adhd_q037", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Limbic_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Control-Limbic connectivity (fc_fc_Cont_Limbic_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "629feeb21e3e9864c374fe0a35b51260f4056a8fc7b7c45d4791bf412ac10a1f", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "629feeb21e3e9864c374fe0a35b51260f4056a8fc7b7c45d4791bf412ac10a1f", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q037", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Control-Limbic connectivity (fc_fc_Cont_Limbic_z), with no additional covariates?", "question_sha256": "196dd3e4394e83b00b491c411759ce51abf92f697318f03791d067b441430cca", "reference_id": "ncb-scientific-629feeb21e3e9864", "scientific_core_sha256": "3c2bb7f77404ad4d112f71c004fbea60dea87d6c07c3b645c04ac4d08226ed9a", "semantic_cluster_id": "ncb-sem-ff10f2963ca8353f", "target_family": "adhd", "task_ids": ["ncb21-task-6bae7b3e8e8252e2"]}
{"aliases": ["normative_fmri_035"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-65466f9b282b22be", "benchmark_track": "scientific", "claim_uid": "ncb-claim-3faf51692de70837", "contract": {"claim_id": "normative_fmri_035", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_SomMot_Vis_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher age associated with lower somatomotor-to-visual connectivity (fc_fc_SomMot_Vis_z), adjusting for sex and cognition?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "65466f9b282b22be1e717ceaf51a11a1383878fa6f0987faf8a0e2a126ffa737", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "65466f9b282b22be1e717ceaf51a11a1383878fa6f0987faf8a0e2a126ffa737", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_035", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher age associated with lower somatomotor-to-visual connectivity (fc_fc_SomMot_Vis_z), adjusting for sex and cognition?", "question_sha256": "fa4fde5a5fdfbbd433747fbd9e5e95781de4d8fda940f64d4b4c99da4ca207b5", "reference_id": "ncb-scientific-65466f9b282b22be", "scientific_core_sha256": "8e8582256f8183b887382f041b4028bab4fb376e9c6acaaf426302c29821a63e", "semantic_cluster_id": "ncb-sem-3faf51692de70837", "target_family": "normative_fmri", "task_ids": ["ncb21-task-dd6c4a9f13fbc09a"]}
{"aliases": ["adhd_q012"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-6560b15c380073ca", "benchmark_track": "scientific", "claim_uid": "ncb-claim-b9ed4cced1a322ad", "contract": {"claim_id": "adhd_q012", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with higher Default-Salience/VentralAttention connectivity (fc_fc_Default_SalVentAttn_z), with no additional covariates, and is the same direction observed in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6560b15c380073caf1f8bfe84bf2978902d6605bfe8aacd3a4262b47295b8f9f", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "6560b15c380073caf1f8bfe84bf2978902d6605bfe8aacd3a4262b47295b8f9f", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q012", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with higher Default-Salience/VentralAttention connectivity (fc_fc_Default_SalVentAttn_z), with no additional covariates, and is the same direction observed in ADHD200_REP?", "question_sha256": "a70e1f9d988aaa993e4c01e912ae225e84ea38b28a642a1cf266e866cc27c789", "reference_id": "ncb-scientific-6560b15c380073ca", "scientific_core_sha256": "5a3fc388953a1d99d7c91f108c87442103cd1d2a95f5fcea35cd97bf1f52b672", "semantic_cluster_id": "ncb-sem-b9ed4cced1a322ad", "target_family": "adhd", "task_ids": ["ncb21-task-38f81a83ea1721fa"]}
{"aliases": ["psychosis_q035"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-66560a7fd0e34141", "benchmark_track": "scientific", "claim_uid": "ncb-claim-6c35024a79091cc0", "contract": {"claim_id": "psychosis_q035", "covariates": [], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across BSNIP2_DISC and BSNIP2_REP, is the SZ-versus-HC contrast for fc_within_network directionally consistent with lower values in SZ in unadjusted comparisons using dx only and no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "66560a7fd0e34141ba219136468ed4d54ee064cfff748f6d27aa451fbfd80069", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "66560a7fd0e34141ba219136468ed4d54ee064cfff748f6d27aa451fbfd80069", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q035", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "Across BSNIP2_DISC and BSNIP2_REP, is the SZ-versus-HC contrast for fc_within_network directionally consistent with lower values in SZ in unadjusted comparisons using dx only and no covariates?", "question_sha256": "b2c71003102c909dd34665617cad7aab274086031a08aad7bde388b035a8a425", "reference_id": "ncb-scientific-66560a7fd0e34141", "scientific_core_sha256": "f83a1ae1018ea674e15dfd64a763eb2404c0875fa6d9ad51b7f5d3e43992a3f2", "semantic_cluster_id": "ncb-sem-6c35024a79091cc0", "target_family": "psychosis", "task_ids": ["ncb21-task-d38cdec7e50cc0a1"]}
{"aliases": ["adhd_q029"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-672ab5d3a6c11820", "benchmark_track": "scientific", "claim_uid": "ncb-claim-5a84905f957c48be", "contract": {"claim_id": "adhd_q029", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Limbic_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered Control-Limbic connectivity (fc_fc_Cont_Limbic_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "672ab5d3a6c11820c5309d195f4983f50a16b545c77a52895353cabd01a16c41", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "672ab5d3a6c11820c5309d195f4983f50a16b545c77a52895353cabd01a16c41", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q029", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered Control-Limbic connectivity (fc_fc_Cont_Limbic_z), with no additional covariates?", "question_sha256": "8069bf44701accf46bd6077c1bf6e256531848908436c8c220dc354c8884d675", "reference_id": "ncb-scientific-672ab5d3a6c11820", "scientific_core_sha256": "57bf1b3c8d9c648dc25efc38e4b6c1114c0ab6b08af9a702809fb5b4ed40105a", "semantic_cluster_id": "ncb-sem-5a84905f957c48be", "target_family": "adhd", "task_ids": ["ncb21-task-9026d43b8d831fe5"]}
{"aliases": ["adhd_q014"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-673bb19e90e472ee", "benchmark_track": "scientific", "claim_uid": "ncb-claim-f1008f8ce10847e7", "contract": {"claim_id": "adhd_q014", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, do participants with any ADHD diagnosis (dx in {1,2,3}) differ from controls (dx=0) in within-Control connectivity (fc_fc_Cont_Cont_z), with no additional covariates, and is the difference replicated in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "673bb19e90e472ee10d6eec6ebed40c685d29a6fc14e9e6ccc9f73a520eaedcb", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "673bb19e90e472ee10d6eec6ebed40c685d29a6fc14e9e6ccc9f73a520eaedcb", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q014", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, do participants with any ADHD diagnosis (dx in {1,2,3}) differ from controls (dx=0) in within-Control connectivity (fc_fc_Cont_Cont_z), with no additional covariates, and is the difference replicated in ADHD200_REP?", "question_sha256": "622641744e830c2f446d55b2fbf3037374ca42fcb462f2a58b6f220fff9599b6", "reference_id": "ncb-scientific-673bb19e90e472ee", "scientific_core_sha256": "e11ee1f210ea000ae296b1e69020239603fa6c24b35d919ed629c59c76f6820c", "semantic_cluster_id": "ncb-sem-f1008f8ce10847e7", "target_family": "adhd", "task_ids": ["ncb21-task-794f22c1c72a1a42"]}
{"aliases": ["pubmed_34183210_pmid34183210_3"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-67542fa55426a130", "benchmark_track": "scientific", "claim_uid": "ncb-claim-11fa9b8767d1b07f", "contract": {"claim_id": "pubmed_34183210_pmid34183210_3", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": "striatal_resting_state_functional_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded non-adherent psychosis relapse after antipsychotic discontinuation vs healthy controls effect on striatal resting-state functional connectivity / striatal connectivity index in fMRI-FC, using BSNIP2 as discovery and COBRE as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "67542fa55426a13052157d88d588a5334147c1872c82514b9edcf4651c8ca7b7", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "67542fa55426a13052157d88d588a5334147c1872c82514b9edcf4651c8ca7b7", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:34183210; DOI:10.1016/j.schres.2021.06.010", "source_collection": "stage2_current", "source_id": "pubmed_34183210_pmid34183210_3", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "For literature-grounded non-adherent psychosis relapse after antipsychotic discontinuation vs healthy controls effect on striatal resting-state functional connectivity / striatal connectivity index in fMRI-FC, using BSNIP2 as discovery and COBRE as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "question_sha256": "5e39442e81e6c65c25df1fa2755209bd778a26106e6ec722718fcc75aa7ba755", "reference_id": "ncb-scientific-67542fa55426a130", "scientific_core_sha256": "58766d8c78f493c84542c891b6c477ad95b2ed1b361d5dd69b1967e40dbc37e9", "semantic_cluster_id": "ncb-sem-11fa9b8767d1b07f", "target_family": "psychosis", "task_ids": []}
{"aliases": ["psychosis_q021"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-675abad09b88a363", "benchmark_track": "scientific", "claim_uid": "ncb-claim-0de9c0c5b4d3defc", "contract": {"claim_id": "psychosis_q021", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_REP, is SZ associated with lower fc_mean_positive than HC in an unadjusted group comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "675abad09b88a3632ae7d7ac4e199a4a0e5c99415e8c1ac16c601d7e16a98f35", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "675abad09b88a3632ae7d7ac4e199a4a0e5c99415e8c1ac16c601d7e16a98f35", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q021", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In ChineseSZ_REP, is SZ associated with lower fc_mean_positive than HC in an unadjusted group comparison using dx as the only predictor and no covariates?", "question_sha256": "8fd27de88aa35b3a6a2ec48c67ab06e612a8dde12ba9d0b206768d8187d88b76", "reference_id": "ncb-scientific-675abad09b88a363", "scientific_core_sha256": "48cce6d09b75baf6211dea22d8f7d4ade78eac5e34dad5210200abd36605c585", "semantic_cluster_id": "ncb-sem-0de9c0c5b4d3defc", "target_family": "psychosis", "task_ids": ["ncb21-task-d78aafebbd1fb7da"]}
{"aliases": ["sex_fc_abcd_hcp"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-67bed34632da1fbb", "benchmark_track": "scientific", "claim_uid": "ncb-claim-36a69884da53bafd", "contract": {"claim_id": "sex_fc_abcd_hcp", "covariates": ["age", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "M", "control": "F", "var": "sex"}, "outcome": "fc_fc_", "predictor": "sex", "region_set": "fMRI-FC", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.2, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For sex association with FC descriptors in fMRI-FC, using ABCD as discovery and HCP as replication, test the claim with expected direction two_sided and adjust for age;site when available.", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "67bed34632da1fbb2023a71e2192bb667fab4f85ea9c595480a539a7e23aae50", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "67bed34632da1fbb2023a71e2192bb667fab4f85ea9c595480a539a7e23aae50", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Ritchie et al. 2018 Cerebral Cortex [VERIFY]", "source_collection": "legacy_scientific", "source_id": "sex_fc_abcd_hcp", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "normative_fmri"}], "question": "For sex association with FC descriptors in fMRI-FC, using ABCD as discovery and HCP as replication, test the claim with expected direction two_sided and adjust for age;site when available.", "question_sha256": "3aaa1f1809b8c707ef7e67b7db358ba1992e07a60225fa069bc2236d5096e2fa", "reference_id": "ncb-scientific-67bed34632da1fbb", "scientific_core_sha256": "1f3f68503dd7b955bd9d971a139be9c9fbac4071ffdfba3c5462f602a8160dac", "semantic_cluster_id": "ncb-sem-36a69884da53bafd", "target_family": "normative_fmri", "task_ids": ["ncb21-task-e2e0ded9afa86172"]}
{"aliases": ["sex_smri_ukb_hcp"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-67d76c2c55e3d767", "benchmark_track": "scientific", "claim_uid": "ncb-claim-89f6c0228c8572ef", "contract": {"claim_id": "sex_smri_ukb_hcp", "covariates": ["age", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "two_sided", "group": {"case": "M", "control": "F", "var": "sex"}, "outcome": "fc_fc_", "predictor": "sex", "region_set": "functional_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 28, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For sex difference in eTIV-adjusted regional volume in sMRI, using UKB as discovery and HCP as replication, test the claim with expected direction two_sided and adjust for age;eTIV;site required when available.", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "67d76c2c55e3d767dcf6aa1e5a4e1eff49b31d287c08991b34d2a15a08da165e", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "67d76c2c55e3d767dcf6aa1e5a4e1eff49b31d287c08991b34d2a15a08da165e", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Ritchie et al. 2018 Cerebral Cortex", "source_collection": "legacy_scientific", "source_id": "sex_smri_ukb_hcp", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "normative_fmri"}], "question": "For sex difference in eTIV-adjusted regional volume in sMRI, using UKB as discovery and HCP as replication, test the claim with expected direction two_sided and adjust for age;eTIV;site required when available.", "question_sha256": "f84689c5daa66fec2ba4e3e2e4cdebbc335389a5b53203fd45a79cf34d78cbab", "reference_id": "ncb-scientific-67d76c2c55e3d767", "scientific_core_sha256": "6b4647c633e7b06b76781002d9099ffae3b1394e712d8dfff64dfab81a426a97", "semantic_cluster_id": "ncb-sem-89f6c0228c8572ef", "target_family": "normative_fmri", "task_ids": []}
{"aliases": ["asd_q016"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-67de4555230bc27a", "benchmark_track": "scientific", "claim_uid": "ncb-claim-19d3c8e27c6bbb4a", "contract": {"claim_id": "asd_q016", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "67de4555230bc27a2720a39d25ba2b54acdc13b8df64eb624e3b7162eb249cbf", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "67de4555230bc27a2720a39d25ba2b54acdc13b8df64eb624e3b7162eb249cbf", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q016", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "654a3102c3e5567fe9888032fe503d19751fd9f4e96af2c0b8f3911ce7009c75", "reference_id": "ncb-scientific-67de4555230bc27a", "scientific_core_sha256": "04cd4c226be0360077fe00bab7174c4acafdd43d7133e6dcd7acace0e45d5a44", "semantic_cluster_id": "ncb-sem-19d3c8e27c6bbb4a", "target_family": "asd", "task_ids": ["ncb21-task-91d790dba534ab02"]}
{"aliases": ["asd_q027"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-68bd56b0483a236c", "benchmark_track": "scientific", "claim_uid": "ncb-claim-e31d66eed7539323", "contract": {"claim_id": "asd_q027", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "68bd56b0483a236c99db6544b25fa5e81003dd38c2af773be2d3d39b9ad070a6", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "68bd56b0483a236c99db6544b25fa5e81003dd38c2af773be2d3d39b9ad070a6", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q027", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "236f6f8d2cc35a40518e8dacfa931adce471b00d7c760cd18c013bf3c54ef816", "reference_id": "ncb-scientific-68bd56b0483a236c", "scientific_core_sha256": "490b163a0c24bbdf0b3f7270828b0f7f828d680b0167fc3731564f6888d3725a", "semantic_cluster_id": "ncb-sem-e31d66eed7539323", "target_family": "asd", "task_ids": ["ncb21-task-d9e401da71a4285e"]}
{"aliases": ["normative_fmri_045"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-690059388e87cd26", "benchmark_track": "scientific", "claim_uid": "ncb-claim-18d8cddf88029c3d", "contract": {"claim_id": "normative_fmri_045", "covariates": ["age", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_Default_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across HCP_DISC and UKB_DISC, with replication in HCP_REP and UKB_REP, do females and males differ consistently in default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for age and cognition within each cohort?", "replication_cohorts": ["UKB_DISC", "HCP_REP", "UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "690059388e87cd26592bbc46e5ac8bbea895a422df119dd8bc4b9991c1c1ad32", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "690059388e87cd26592bbc46e5ac8bbea895a422df119dd8bc4b9991c1c1ad32", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_045", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "Across HCP_DISC and UKB_DISC, with replication in HCP_REP and UKB_REP, do females and males differ consistently in default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for age and cognition within each cohort?", "question_sha256": "29ddfc5ddd8bde3c001566daff310ec9dcd45c7fba2b0f60a978c4e94749f38c", "reference_id": "ncb-scientific-690059388e87cd26", "scientific_core_sha256": "7f09b0ca6508f70bc0a84626ffe5d49d534c989458cfb84c6f7423d16849ecac", "semantic_cluster_id": "ncb-sem-18d8cddf88029c3d", "target_family": "normative_fmri", "task_ids": []}
{"aliases": ["ad_aging_q050"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-693510493058a91a", "benchmark_track": "scientific", "claim_uid": "ncb-claim-35aeb4ea0eac989b", "contract": {"claim_id": "ad_aging_q050", "covariates": ["sex", "site"], "discovery_cohort": "ADNI_fMRI_REP", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_Default_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "In ADNI_fMRI_REP, among participants with diagnosis code 0.0, is older age associated with lower fc_fc_Default_Default_z, adjusting for sex?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "693510493058a91ac8ead80536de2a54f1331e925b11ad3d69d871fe6c93a395", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "693510493058a91ac8ead80536de2a54f1331e925b11ad3d69d871fe6c93a395", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q050", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_fMRI_REP, among participants with diagnosis code 0.0, is older age associated with lower fc_fc_Default_Default_z, adjusting for sex?", "question_sha256": "aa45e9ce98d6bf9a085b236d361b96eb961449b6585db351c1c053c0992f5275", "reference_id": "ncb-scientific-693510493058a91a", "scientific_core_sha256": "e1564050ab1fc9e445ec99036e312ef4c6c69e6d0563e73d20263bc9ff980391", "semantic_cluster_id": "ncb-sem-35aeb4ea0eac989b", "target_family": "ad_aging", "task_ids": ["ncb21-task-ddff0dc3276c59c9"]}
{"aliases": ["adhd_q019"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-693e96c3edd41a98", "benchmark_track": "scientific", "claim_uid": "ncb-claim-121f221d8a57572f", "contract": {"claim_id": "adhd_q019", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Visual-Default connectivity (fc_fc_Default_Vis_z), with no additional covariates, and does this association replicate in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "693e96c3edd41a9856cb1b6e96bb8253640f34d8470d19f03c7bab4b2b47a73d", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "693e96c3edd41a9856cb1b6e96bb8253640f34d8470d19f03c7bab4b2b47a73d", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q019", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Visual-Default connectivity (fc_fc_Default_Vis_z), with no additional covariates, and does this association replicate in ADHD200_REP?", "question_sha256": "ab7b279cffe1cafac8c3ae4aabe1b8cc35215766552fc9a17aef05bcb0ddb4aa", "reference_id": "ncb-scientific-693e96c3edd41a98", "scientific_core_sha256": "f2dfca6472dd2670c00861835cf4779072c3f6a97fb6af749b423d53d0ced7dd", "semantic_cluster_id": "ncb-sem-121f221d8a57572f", "target_family": "adhd", "task_ids": ["ncb21-task-79d124c80a9f3f93"]}
{"aliases": ["psychosis_q018"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-6aa47e3b129ad9fb", "benchmark_track": "scientific", "claim_uid": "ncb-claim-893ac2c9b485762f", "contract": {"claim_id": "psychosis_q018", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_DISC, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted dx-only group comparison with no covariates?", "replication_cohorts": ["ChineseSZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6aa47e3b129ad9fb3b897f8e59d71e00f8f3abe34d5515c19a65bf8a5c880e1a", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "6aa47e3b129ad9fb3b897f8e59d71e00f8f3abe34d5515c19a65bf8a5c880e1a", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q018", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In ChineseSZ_DISC, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted dx-only group comparison with no covariates?", "question_sha256": "074c94e46de6318e076d953f0b4b4512f273a90851b345b12aa65fe8e6a544d2", "reference_id": "ncb-scientific-6aa47e3b129ad9fb", "scientific_core_sha256": "1f25292a340946358354a285063b38888d03785da7aa7745ad6744533f28ed4e", "semantic_cluster_id": "ncb-sem-893ac2c9b485762f", "target_family": "psychosis", "task_ids": ["ncb21-task-6ff6d5213109f836"]}
{"aliases": ["adhd_q004"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-6bedac272110f713", "benchmark_track": "scientific", "claim_uid": "ncb-claim-57936e3548ab028f", "contract": {"claim_id": "adhd_q004", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "confirm_dx in [\"case\", \"control\"]", "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with lower Control-DorsalAttention connectivity (fc_fc_Cont_DorsAttn_z), with no additional covariates, and does ABCD_REP show the same direction?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6bedac272110f71307ba214166242c783aaabb9d2c90371d6e25cf14b2258297", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "6bedac272110f71307ba214166242c783aaabb9d2c90371d6e25cf14b2258297", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q004", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with lower Control-DorsalAttention connectivity (fc_fc_Cont_DorsAttn_z), with no additional covariates, and does ABCD_REP show the same direction?", "question_sha256": "aafddaff6e02d26deda394069fd3fddfb42755355228d65e871f1ec7543099f9", "reference_id": "ncb-scientific-6bedac272110f713", "scientific_core_sha256": "176c043ea40f5f2781744b1c5ce5ad49f5ea34bde41c1a573055e15479085f69", "semantic_cluster_id": "ncb-sem-57936e3548ab028f", "target_family": "adhd", "task_ids": ["ncb21-task-b223c5ff80096a89"]}
{"aliases": ["adhd_q025"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-scientific-6c7b0f8ae69a2d50", "benchmark_track": "scientific", "claim_uid": "ncb-claim-6724d26a22b969a6", "contract": {"claim_id": "adhd_q025", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SomMot_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, does ADHD-hyperactive/impulsive type (dx=3) differ from ADHD-inattentive type (dx=2) in Somatomotor-Somatomotor connectivity (fc_fc_SomMot_SomMot_z), with no additional covariates, and is the contrast replicated in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6c7b0f8ae69a2d5037f71bb7af54369267c1d4746b35ba4b0575665297cfaab0", "migration_status": "non_executable", "modality": "fMRI-FC", "pre_v2_contract_sha256": "6c7b0f8ae69a2d5037f71bb7af54369267c1d4746b35ba4b0575665297cfaab0", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q025", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, does ADHD-hyperactive/impulsive type (dx=3) differ from ADHD-inattentive type (dx=2) in Somatomotor-Somatomotor connectivity (fc_fc_SomMot_SomMot_z), with no additional covariates, and is the contrast replicated in ADHD200_REP?", "question_sha256": "dfddb3a0185d744191436b6ac4caab79daa99d54a84b4d8c6324a84fe0f3ff04", "reference_id": "ncb-scientific-6c7b0f8ae69a2d50", "scientific_core_sha256": "5b1608974e8fadeccefbd272ad1e26c06d6524bc8c28f4a0e215bb384e28d7ed", "semantic_cluster_id": "ncb-sem-6724d26a22b969a6", "target_family": "adhd", "task_ids": []}
{"aliases": ["psychosis_q012"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-6c9d8d248e03fd07", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2ccad72c3141229c", "contract": {"claim_id": "psychosis_q012", "covariates": [], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_DISC, do SZ and HC participants differ in fc_between_network in an unadjusted dx-only group comparison with no covariates?", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6c9d8d248e03fd072175b3155b829fce548d5dc88bffc0dd63db73a27cc1b1f9", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "6c9d8d248e03fd072175b3155b829fce548d5dc88bffc0dd63db73a27cc1b1f9", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q012", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In COBRE_DISC, do SZ and HC participants differ in fc_between_network in an unadjusted dx-only group comparison with no covariates?", "question_sha256": "f4973facbde2385f27bbaeeb38405ae850c4a5ef31c8a96a6f710a6288abebf7", "reference_id": "ncb-scientific-6c9d8d248e03fd07", "scientific_core_sha256": "86ac435effa92a0f64b37975853f1406de1ee6fe4d022ede8113f40c84ef8e63", "semantic_cluster_id": "ncb-sem-2ccad72c3141229c", "target_family": "psychosis", "task_ids": ["ncb21-task-6e851b324b0b1e82"]}
{"aliases": ["adhd_q032"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-6d7bbb66ca61d088", "benchmark_track": "scientific", "claim_uid": "ncb-claim-1b16849bd998d463", "contract": {"claim_id": "adhd_q032", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "confirm_dx in [\"case\", \"control\"]", "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered within-Salience/VentralAttention connectivity (fc_fc_SalVentAttn_SalVentAttn_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6d7bbb66ca61d088b1b6677f1693112e85a9ec6c6c0e8c82beb93a4244532157", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "6d7bbb66ca61d088b1b6677f1693112e85a9ec6c6c0e8c82beb93a4244532157", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q032", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered within-Salience/VentralAttention connectivity (fc_fc_SalVentAttn_SalVentAttn_z), with no additional covariates?", "question_sha256": "b9fb1e9b10e4839537b121eb2ac8ba4bd59f83dc0db8480cccc887c2aa6e3d95", "reference_id": "ncb-scientific-6d7bbb66ca61d088", "scientific_core_sha256": "cef9e6c85de79d3d6756e4d8e3c2a56cd806e99cdcb5ab3626e417ae41aef8dc", "semantic_cluster_id": "ncb-sem-1b16849bd998d463", "target_family": "adhd", "task_ids": ["ncb21-task-cfee782015d454f9"]}
{"aliases": ["cognition_fc_ukb_abcd"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-6efb2475137e21ce", "benchmark_track": "scientific", "claim_uid": "ncb-claim-9a1ca31c71c1e012", "contract": {"claim_id": "cognition_fc_ukb_abcd", "covariates": ["age", "sex", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_", "predictor": "phen_height", "region_set": "fc_descriptors", "type": "association", "unit": "brainwide"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.2, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For cognition association with FC descriptors in fMRI-FC, using UKB as discovery and ABCD as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "6efb2475137e21ce5e04d1f2becdf22e974672a1fef3082b57f6ccc88919cc0b", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "6efb2475137e21ce5e04d1f2becdf22e974672a1fef3082b57f6ccc88919cc0b", "provenance": [{"prior_label": "underpowered_small_positive", "source_citation": "Marek et al. 2022 Nature", "source_collection": "legacy_scientific", "source_id": "cognition_fc_ukb_abcd", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "normative_fmri"}], "question": "For cognition association with FC descriptors in fMRI-FC, using UKB as discovery and ABCD as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "question_sha256": "3767efb0bc926c60ec7734794cc836d1ff14879870a3cb4ca1ba8854e592519f", "reference_id": "ncb-scientific-6efb2475137e21ce", "scientific_core_sha256": "ec60717557c4f96293f360658be981e60b0ad479debdac8a8b89cf402d8892df", "semantic_cluster_id": "ncb-sem-9a1ca31c71c1e012", "target_family": "normative_fmri", "task_ids": []}
{"aliases": ["normative_fmri_001"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-6f07b924f78e762d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-1e00529a89dced24", "contract": {"claim_id": "normative_fmri_001", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_Default_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower within-network default-mode connectivity (fc_fc_Default_Default_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6f07b924f78e762dbb04192421df62ac5dd24835b8e50993a3f5c2cdf333e66c", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "6f07b924f78e762dbb04192421df62ac5dd24835b8e50993a3f5c2cdf333e66c", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_001", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower within-network default-mode connectivity (fc_fc_Default_Default_z), adjusting for sex and cognition?", "question_sha256": "4d7298eb66c722a70b4bac20a8e6de4ad6974e0039e7e12c984a6983f924c52c", "reference_id": "ncb-scientific-6f07b924f78e762d", "scientific_core_sha256": "984c1b7aa9006c12806a12042a62e1cd3b282f6b95bd928ee3c6451cba48a885", "semantic_cluster_id": "ncb-sem-1e00529a89dced24", "target_family": "normative_fmri", "task_ids": ["ncb21-task-9b937c1f9c6db20c"]}
{"aliases": ["normative_fmri_022"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-704522685c487d81", "benchmark_track": "scientific", "claim_uid": "ncb-claim-0e2fdf4f1720ce06", "contract": {"claim_id": "normative_fmri_022", "covariates": ["age", "sex", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_DorsAttn_DorsAttn_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, is higher cognition associated with higher dorsal-attention within-network connectivity (fc_fc_DorsAttn_DorsAttn_z), adjusting for age and sex?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "704522685c487d817c358b1648972cf4b93110fe504eef340f7662e1605fe2af", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "704522685c487d817c358b1648972cf4b93110fe504eef340f7662e1605fe2af", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_022", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In HCP_DISC, with replication in HCP_REP, is higher cognition associated with higher dorsal-attention within-network connectivity (fc_fc_DorsAttn_DorsAttn_z), adjusting for age and sex?", "question_sha256": "33fa3ec69b7b9eec6fe26b51c3bd67b129d4b0aca9cf3fe70527eff9a3a3afcb", "reference_id": "ncb-scientific-704522685c487d81", "scientific_core_sha256": "4fe70484eb4157a7d8527f5212b6cb1e6fcebbd11d246a369bf2d873aa1acf30", "semantic_cluster_id": "ncb-sem-0e2fdf4f1720ce06", "target_family": "normative_fmri", "task_ids": ["ncb21-task-f55b77723d0aed8e"]}
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{"aliases": ["ad_aging_q030"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-75bd3855eddc86c8", "benchmark_track": "scientific", "claim_uid": "ncb-claim-e7f683ba9f4d54de", "contract": {"claim_id": "ad_aging_q030", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_entorhinal", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In OASIS3_DISC, among CN participants, is older age associated with lower smri_entorhinal, adjusting for sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "75bd3855eddc86c8164fd4b8c788b0d2ff249afef49acbd1c2597bcf3031ee46", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "75bd3855eddc86c8164fd4b8c788b0d2ff249afef49acbd1c2597bcf3031ee46", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q030", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In OASIS3_DISC, among CN participants, is older age associated with lower smri_entorhinal, adjusting for sex?", "question_sha256": "6f0907673bf01f1942bf4d9937753d8606b393fafc2e1dc7d976cc6d1ab181ec", "reference_id": "ncb-scientific-75bd3855eddc86c8", "scientific_core_sha256": "e259a2f505105f9436d1d175cb4fc14234be85dc14310bc91f6d757bb2b12716", "semantic_cluster_id": "ncb-sem-e7f683ba9f4d54de", "target_family": "ad_aging", "task_ids": ["ncb21-task-6d3364afde7ca34a"]}
{"aliases": ["ad_aging_q009", "ad_aging_q011"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-7761a54a90d0f99d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-ed01d7c380e3f82b", "contract": {"claim_id": "ad_aging_q009", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_entorhinal", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is MCI associated with lower smri_entorhinal than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7761a54a90d0f99d858c02400a8a9c8f3bd8d12c6bf72880e708940a1e95251c", "migration_status": "ambiguous_unresolved", "modality": "sMRI", "pre_v2_contract_sha256": "7761a54a90d0f99d858c02400a8a9c8f3bd8d12c6bf72880e708940a1e95251c", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q009", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}, {"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q011", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is MCI associated with lower smri_entorhinal than CN, adjusting for age and sex?", "question_sha256": "1d3b7776dbdd3bd2466c1cdffefff855447108e05aa2e7fec6c7ce6b542c3e01", "reference_id": "ncb-scientific-7761a54a90d0f99d", "scientific_core_sha256": "6a2f1d3c8fabd65bf09e32a09eafd6e46b77f3b3c3a3a91783f80ea089128cb3", "semantic_cluster_id": "ncb-sem-ed01d7c380e3f82b", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["ad_aging_q046"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-79182620041b5799", "benchmark_track": "scientific", "claim_uid": "ncb-claim-eb5dda014080c769", "contract": {"claim_id": "ad_aging_q046", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADNI_fMRI_REP", "estimand": {"direction": "negative", "group": {"case": "1.0", "control": "0.0", "var": "dx"}, "outcome": "fc_fc_Default_Default_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ADNI_fMRI_REP, excluding participants with missing diagnosis code, is diagnosis code 1.0 associated with lower fc_fc_Default_Default_z than diagnosis code 0.0, adjusting for age and sex?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "79182620041b57998eb9b3eb81cfba653f320fbe529ff0db654dd813626d0e36", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "79182620041b57998eb9b3eb81cfba653f320fbe529ff0db654dd813626d0e36", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q046", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_fMRI_REP, excluding participants with missing diagnosis code, is diagnosis code 1.0 associated with lower fc_fc_Default_Default_z than diagnosis code 0.0, adjusting for age and sex?", "question_sha256": "61757c25b7c125d383d1baa9fdfa79fd6b92139fdbbf27541766ed623ccc8900", "reference_id": "ncb-scientific-79182620041b5799", "scientific_core_sha256": "aefeb590084f636e3cdc8b4b54ca7e32c7b6ae8b45ccd2497b344758ad3a0091", "semantic_cluster_id": "ncb-sem-eb5dda014080c769", "target_family": "ad_aging", "task_ids": ["ncb21-task-0a3153ea01de1eb9"]}
{"aliases": ["ad_aging_q005"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-792968836011440a", "benchmark_track": "scientific", "claim_uid": "ncb-claim-5ec25f86a95995a3", "contract": {"claim_id": "ad_aging_q005", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_midtemp", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with lower smri_midtemp than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "792968836011440afaa2e9f79b4c506d6dbabdb10a3878b0c91aa60f7e6ca696", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "792968836011440afaa2e9f79b4c506d6dbabdb10a3878b0c91aa60f7e6ca696", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q005", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with lower smri_midtemp than CN, adjusting for age and sex?", "question_sha256": "288133858c3adbbc647a71463b288b7a5482b4d8987b04546936f7b45de44d12", "reference_id": "ncb-scientific-792968836011440a", "scientific_core_sha256": "932639475f875c136afd0628e9ba6621e6a676ad5335136185f9152ce0a5e9ff", "semantic_cluster_id": "ncb-sem-5ec25f86a95995a3", "target_family": "ad_aging", "task_ids": ["ncb21-task-c960d04f2a3a502e"]}
{"aliases": ["asd_q015"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-7a87a86398becf44", "benchmark_track": "scientific", "claim_uid": "ncb-claim-74f061d5c7506b17", "contract": {"claim_id": "asd_q015", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_SalVentAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7a87a86398becf44806656c7b8437f675f371fd6f2644ac257e562ca90b86a6a", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "7a87a86398becf44806656c7b8437f675f371fd6f2644ac257e562ca90b86a6a", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q015", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "33e89aec59a3bf8a0b69e34d581e8d06c4a3196d0dac05b9939e1d0f86d00201", "reference_id": "ncb-scientific-7a87a86398becf44", "scientific_core_sha256": "841436aa29efcdba7c2bd0d7368f0e059f0e3344f8fb82cfbbbd1cb375d12d2a", "semantic_cluster_id": "ncb-sem-74f061d5c7506b17", "target_family": "asd", "task_ids": ["ncb21-task-cecdff58b47a089c"]}
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{"aliases": ["normative_fmri_019"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-7be5e0886589fedd", "benchmark_track": "scientific", "claim_uid": "ncb-claim-dfc290f3eccf477b", "contract": {"claim_id": "normative_fmri_019", "covariates": ["age", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Limbic_Limbic_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, do females and males differ in limbic within-network connectivity (fc_fc_Limbic_Limbic_z), adjusting for age and cognition?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7be5e0886589fedd176d8f8a4351a86533239f8929f35db4651ba564298bca62", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "7be5e0886589fedd176d8f8a4351a86533239f8929f35db4651ba564298bca62", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_019", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In HCP_DISC, with replication in HCP_REP, do females and males differ in limbic within-network connectivity (fc_fc_Limbic_Limbic_z), adjusting for age and cognition?", "question_sha256": "530e5c21bfc8d9fae437f44614c53c11ecbb23847a4503ce32eeea8747378e71", "reference_id": "ncb-scientific-7be5e0886589fedd", "scientific_core_sha256": "59b5fc6addd3e1e598a2e191a53f7349a2d8c9ea524c43da926a8f0f8d09ce57", "semantic_cluster_id": "ncb-sem-dfc290f3eccf477b", "target_family": "normative_fmri", "task_ids": ["ncb21-task-c876031a0856d8ed"]}
{"aliases": ["adhd_q023"], "alignment_disposition": "repairable_contract", "benchmark_case_id": "ncb-scientific-7c005de1c12b32a7", "benchmark_track": "scientific", "claim_uid": "ncb-claim-1a9a8b1891c46711", "contract": {"claim_id": "adhd_q023", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "positive", "group": {"case": "3", "control": "0", "var": "dx"}, "outcome": "fc_fc_SalVentAttn_SomMot_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx in [\"0\", \"3\"]", "question": "In ADHD200_DISC, does ADHD-hyperactive/impulsive type (dx=3) versus control (dx=0) show higher Salience/VentralAttention-Somatomotor connectivity (fc_fc_SalVentAttn_SomMot_z), with no additional covariates, and is the same direction present in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "22e9dad3dc77b808e6883b1259492c9cf8f1bb52d57623e5d3afd28fd4ecd81a", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "7c005de1c12b32a7b7a45e61565deb980582119a1b92e7e4f0083c9e8537a1d0", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q023", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, does ADHD-hyperactive/impulsive type (dx=3) versus control (dx=0) show higher Salience/VentralAttention-Somatomotor connectivity (fc_fc_SalVentAttn_SomMot_z), with no additional covariates, and is the same direction present in ADHD200_REP?", "question_sha256": "af8cd98c7b6f26a204bc6fac60ce7fdcd95301834414de7f8837e25b758e1b22", "reference_id": "ncb-scientific-7c005de1c12b32a7", "scientific_core_sha256": "afd979c1a5acc5968516aa285022d6e3eea5fcd67466bcc45b0dd081980a11db", "semantic_cluster_id": "ncb-sem-1a9a8b1891c46711", "target_family": "adhd", "task_ids": ["ncb21-task-4909693e2ac000b8"]}
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{"aliases": ["pubmed_35388950_pmid35388950_ad_hav_volumes"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-7c66a10417fcec23", "benchmark_track": "scientific", "claim_uid": "ncb-claim-9725e2d6c7a99178", "contract": {"claim_id": "pubmed_35388950_pmid35388950_ad_hav_volumes", "covariates": ["age", "eTIV", "sex"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_", "predictor": "confirm_dx", "region_set": "AD_related_smri_volumes", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "eTIV", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 6, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded Alzheimer disease versus normal aging control status effect on AD-related structural atrophy pattern in sMRI volumetric MRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction two_sided and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7c66a10417fcec235ed58bc5f85855df3d432c60693fa1bf4758147bfb882606", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "7c66a10417fcec235ed58bc5f85855df3d432c60693fa1bf4758147bfb882606", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:35388950; DOI:10.1002/hbm.25850", "source_collection": "stage2_current", "source_id": "pubmed_35388950_pmid35388950_ad_hav_volumes", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "For literature-grounded Alzheimer disease versus normal aging control status effect on AD-related structural atrophy pattern in sMRI volumetric MRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction two_sided and adjust for age;eTIV;sex when available.", "question_sha256": "1077a6329450b1493818e951eefaf9a1918c00ec0d8763461e263fa9833b1f23", "reference_id": "ncb-scientific-7c66a10417fcec23", "scientific_core_sha256": "8eba6d86a6275d37758772abe9d281aac14b3ecc57cff96ed9267a4a2247a561", "semantic_cluster_id": "ncb-sem-9725e2d6c7a99178", "target_family": "ad_aging", "task_ids": ["ncb21-task-a1a56104fcdaf492"]}
{"aliases": ["sz_brainwide_fc_4cohort"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-7c8fd02a769bcd9a", "benchmark_track": "scientific", "claim_uid": "ncb-claim-9086d74191ad7d9b", "contract": {"claim_id": "sz_brainwide_fc_4cohort", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For SZ brain-wide FNC dysconnectivity pattern (100-IC edge-level) in fMRI-FC, using ChineseSZ as discovery and BSNIP2;JH;BSNIP1 as replication, test the claim with expected direction two_sided distributed pattern and adjust for age;sex (no motion available).", "replication_cohorts": ["BSNIP2_REP", "JH_REP", "BSNIP_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "preregistered"}}, "contract_sha256": "7c8fd02a769bcd9a50c58371dc350ccdbc8a4ee13f120f120f0bbcd3b15a000f", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "7c8fd02a769bcd9a50c58371dc350ccdbc8a4ee13f120f120f0bbcd3b15a000f", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Pettersson-Yeo et al. 2011 Neuroscience and Biobehavioral Reviews", "source_collection": "legacy_scientific", "source_id": "sz_brainwide_fc_4cohort", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "psychosis"}], "question": "For SZ brain-wide FNC dysconnectivity pattern (100-IC edge-level) in fMRI-FC, using ChineseSZ as discovery and BSNIP2;JH;BSNIP1 as replication, test the claim with expected direction two_sided distributed pattern and adjust for age;sex (no motion available).", "question_sha256": "6e926668ee2102fe15bfb78e98e843358b9bd05425dc94eb7cb40b8460de631c", "reference_id": "ncb-scientific-7c8fd02a769bcd9a", "scientific_core_sha256": "f195a54175bfefe1dc78325623429d9ed0af8a9562b49d2cc5266443582b657c", "semantic_cluster_id": "ncb-sem-9086d74191ad7d9b", "target_family": "psychosis", "task_ids": ["ncb21-task-b23feae2580b6639"]}
{"aliases": ["psychosis_q001"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-7cb3fe4a5738fae5", "benchmark_track": "scientific", "claim_uid": "ncb-claim-f6629357fa60f0d6", "contract": {"claim_id": "psychosis_q001", "covariates": [], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 1.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_DISC, is schizophrenia diagnosis (SZ vs HC) associated with lower fc_mean_positive in an unadjusted group comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7cb3fe4a5738fae59ad565ce7ad320774954e407c9d8edcbc6f05c4bb1287017", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "7cb3fe4a5738fae59ad565ce7ad320774954e407c9d8edcbc6f05c4bb1287017", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q001", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In BSNIP2_DISC, is schizophrenia diagnosis (SZ vs HC) associated with lower fc_mean_positive in an unadjusted group comparison with dx as the only predictor and no covariates?", "question_sha256": "e6e102f113b269f763eab83986c910eb619c569bf94e26fb7d502e643c9f9c56", "reference_id": "ncb-scientific-7cb3fe4a5738fae5", "scientific_core_sha256": "7fedec7ed8e4dc3d05cd7dadb1c86170d525ed083ff3d48f470d3581a11a3a16", "semantic_cluster_id": "ncb-sem-f6629357fa60f0d6", "target_family": "psychosis", "task_ids": ["ncb21-task-e64e38fc45ab30a8"]}
{"aliases": ["ad_aging_q027"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-7f4258667f94f44d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-f3e4911f433998d2", "contract": {"claim_id": "ad_aging_q027", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_hippocampus", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In OASIS3_DISC, among CN participants, is older age associated with lower smri_hippocampus, adjusting for sex?", "replication_cohorts": ["OASIS3_REP", "ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7f4258667f94f44d5e73e949aab05c8374dbe1ac010e146956307f30d3201ba2", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "7f4258667f94f44d5e73e949aab05c8374dbe1ac010e146956307f30d3201ba2", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q027", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In OASIS3_DISC, among CN participants, is older age associated with lower smri_hippocampus, adjusting for sex?", "question_sha256": "e08530a1ce66821e0185b99544e99b7af362c6c7ec77a4a3089fb24d52bb2103", "reference_id": "ncb-scientific-7f4258667f94f44d", "scientific_core_sha256": "366fb3b38fdadfe5baaa3273d0ba2c983d3068cfecb137d67dc4668c1c965265", "semantic_cluster_id": "ncb-sem-f3e4911f433998d2", "target_family": "ad_aging", "task_ids": ["ncb21-task-c56dc7c61f203feb"]}
{"aliases": ["normative_fmri_012"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-7fc6845e80fabb9d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-cea69597c870b6b8", "contract": {"claim_id": "normative_fmri_012", "covariates": ["age", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, do females and males differ in control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7fc6845e80fabb9db8918b62e791d797a9227a8aa7499272e4c4a47064ebeab2", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "7fc6845e80fabb9db8918b62e791d797a9227a8aa7499272e4c4a47064ebeab2", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_012", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In UKB_DISC, with replication in UKB_REP, do females and males differ in control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and cognition?", "question_sha256": "d797a96575579058b8b096f02c8b1246f793585d4f7f66d8eb9d8b430f4bcb7b", "reference_id": "ncb-scientific-7fc6845e80fabb9d", "scientific_core_sha256": "6acd0e917b7a5125547dc4ec1446930f03f7f150670a3b8ccfc1ffac2c40019d", "semantic_cluster_id": "ncb-sem-cea69597c870b6b8", "target_family": "normative_fmri", "task_ids": ["ncb21-task-713ca9b6955d7a40"]}
{"aliases": ["asd_q022"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-7fe9235c8d5841b2", "benchmark_track": "scientific", "claim_uid": "ncb-claim-1bcf71f03d32a2b8", "contract": {"claim_id": "asd_q022", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7fe9235c8d5841b21b4e02f5f1ea3da19d265b3dae41e4689eb549064708d519", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "7fe9235c8d5841b21b4e02f5f1ea3da19d265b3dae41e4689eb549064708d519", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q022", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "8006929afd02e83488b6b126559c6871c27e67f92e44168157621b5323681d50", "reference_id": "ncb-scientific-7fe9235c8d5841b2", "scientific_core_sha256": "b3c6ea4e5788f95c4b4d4933521dd03c467139c479d75d0309f068ff344958e8", "semantic_cluster_id": "ncb-sem-1bcf71f03d32a2b8", "target_family": "asd", "task_ids": ["ncb21-task-52fb8c2bbe143797"]}
{"aliases": ["psychosis_q020"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-8014ff72ff0a06a0", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a44d2718db4923a4", "contract": {"claim_id": "psychosis_q020", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_DISC, do SZ and HC participants differ in fc_between_network in an unadjusted dx-only comparison with no covariates?", "replication_cohorts": ["ChineseSZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "8014ff72ff0a06a0aa8de224052dec1b0bd5ed72ab1609e53885372944ee3b2a", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "8014ff72ff0a06a0aa8de224052dec1b0bd5ed72ab1609e53885372944ee3b2a", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q020", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In ChineseSZ_DISC, do SZ and HC participants differ in fc_between_network in an unadjusted dx-only comparison with no covariates?", "question_sha256": "1c93b1b79453920d69cb5870800a394a6a6714aa4623666b1013c63ce7347635", "reference_id": "ncb-scientific-8014ff72ff0a06a0", "scientific_core_sha256": "fb5490c0f9830bab67ec304a1909322e1353331b5565a5c9acb64000b9de418d", "semantic_cluster_id": "ncb-sem-a44d2718db4923a4", "target_family": "psychosis", "task_ids": ["ncb21-task-f1b4943c48b52530"]}
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{"aliases": ["asd_q028"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-83e8c22eb0f4831a", "benchmark_track": "scientific", "claim_uid": "ncb-claim-3d9da92d0c9e16b2", "contract": {"claim_id": "asd_q028", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "83e8c22eb0f4831ab466f92d33a57545f9a4ac8eb8d3c9af44021b75c7fef4c4", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "83e8c22eb0f4831ab466f92d33a57545f9a4ac8eb8d3c9af44021b75c7fef4c4", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q028", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "0bc71a22cf8f7ec2bcf4ebf922aae80b71cd6a4ff053429780628fbac2d1d82b", "reference_id": "ncb-scientific-83e8c22eb0f4831a", "scientific_core_sha256": "93ccb767b027dfaa402523d74235849cb5cf06b144260572cb441747719f7ceb", "semantic_cluster_id": "ncb-sem-3d9da92d0c9e16b2", "target_family": "asd", "task_ids": ["ncb21-task-22b6347de5b895fd"]}
{"aliases": ["normative_fmri_013"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-8482b5c202e5e323", "benchmark_track": "scientific", "claim_uid": "ncb-claim-b36b546a147ac8c8", "contract": {"claim_id": "normative_fmri_013", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_Default_Default_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, is higher age associated with altered default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for sex and cognition?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "8482b5c202e5e3235de8c6063dda4b78550e3f9e00df27d431e2d1f0d720b4aa", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "8482b5c202e5e3235de8c6063dda4b78550e3f9e00df27d431e2d1f0d720b4aa", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_013", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In HCP_DISC, with replication in HCP_REP, is higher age associated with altered default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for sex and cognition?", "question_sha256": "1d30ca98b79841f53b77865c3dda5071edfd5285e121fc3805f2ee68ca7521b3", "reference_id": "ncb-scientific-8482b5c202e5e323", "scientific_core_sha256": "c66e07626429ff9c193acb0de6f210b628f29af3dc8c55350b1c5649e95cd55b", "semantic_cluster_id": "ncb-sem-b36b546a147ac8c8", "target_family": "normative_fmri", "task_ids": ["ncb21-task-7e0c5c0ce3670607"]}
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{"aliases": ["psychosis_q003"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-872c426870a43fc0", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2166e66544e56e96", "contract": {"claim_id": "psychosis_q003", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_DISC, is SZ associated with lower fc_within_network than HC in an unadjusted comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "872c426870a43fc09bee7deefd9487ffedf554184b618cfa1548e9f8d3be8d34", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "872c426870a43fc09bee7deefd9487ffedf554184b618cfa1548e9f8d3be8d34", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q003", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In BSNIP2_DISC, is SZ associated with lower fc_within_network than HC in an unadjusted comparison with dx as the only predictor and no covariates?", "question_sha256": "af1e3ea30c2d14dca25b864e581917b849d1fce778a0ae1bb2311ff513f67c9e", "reference_id": "ncb-scientific-872c426870a43fc0", "scientific_core_sha256": "fe62e3ac6d28beb064c5546f2587c5a19f801cdd2d676bd8f8bb68fb9a52a192", "semantic_cluster_id": "ncb-sem-2166e66544e56e96", "target_family": "psychosis", "task_ids": ["ncb21-task-a05795cc3d5cda20"]}
{"aliases": ["pubmed_30833582_pmid30833582_asd_stepwise_connectivity"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-88422a822641e7cd", "benchmark_track": "scientific", "claim_uid": "ncb-claim-b6e178b76bfe939a", "contract": {"claim_id": "pubmed_30833582_pmid30833582_asd_stepwise_connectivity", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "task_free_functional_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded autism diagnosis versus typically developing controls effect on stepwise sensory-to-transmodal functional connectivity in task-free fMRI functional connectivity, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "88422a822641e7cdcba6f457a4fa41387a32f9f3a60e08260ef9b6a18e716ada", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "88422a822641e7cdcba6f457a4fa41387a32f9f3a60e08260ef9b6a18e716ada", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:30833582; DOI:10.1038/s41467-019-08944-1", "source_collection": "stage2_current", "source_id": "pubmed_30833582_pmid30833582_asd_stepwise_connectivity", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "For literature-grounded autism diagnosis versus typically developing controls effect on stepwise sensory-to-transmodal functional connectivity in task-free fMRI functional connectivity, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "question_sha256": "63cd65b8854b8da56cfc9659d38234046563e6896892bfc4b961d76ed31802ac", "reference_id": "ncb-scientific-88422a822641e7cd", "scientific_core_sha256": "a3a21ca7fd85dfc675679004d6b96975942453106ddf192a789454f88cec1c98", "semantic_cluster_id": "ncb-sem-b6e178b76bfe939a", "target_family": "asd", "task_ids": ["ncb21-task-ef11da7859dbdd5a"]}
{"aliases": ["adhd_q008"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-8875a7bf33df9519", "benchmark_track": "scientific", "claim_uid": "ncb-claim-02e98abc510ab3f0", "contract": {"claim_id": "adhd_q008", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with higher Salience/VentralAttention-Somatomotor connectivity (fc_fc_SalVentAttn_SomMot_z), with no additional covariates, and is the same direction seen in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "8875a7bf33df951977e26ecd4ecf5885a3a6e08b889d220be4400f20649c8706", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "8875a7bf33df951977e26ecd4ecf5885a3a6e08b889d220be4400f20649c8706", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q008", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with higher Salience/VentralAttention-Somatomotor connectivity (fc_fc_SalVentAttn_SomMot_z), with no additional covariates, and is the same direction seen in ABCD_REP?", "question_sha256": "042de82b6e180575d97e5abc72a24dcbb9d282effef3e184634dd3d8f6251552", "reference_id": "ncb-scientific-8875a7bf33df9519", "scientific_core_sha256": "7e6d38439f6ee87030614990e069263200ba1b75ef2ffc9fa29f6ae8356d6e15", "semantic_cluster_id": "ncb-sem-02e98abc510ab3f0", "target_family": "adhd", "task_ids": ["ncb21-task-084549e934cf6e3a"]}
{"aliases": ["normative_fmri_042"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-89c7369d95a29475", "benchmark_track": "scientific", "claim_uid": "ncb-claim-e945cecc98941bef", "contract": {"claim_id": "normative_fmri_042", "covariates": ["sex", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across UKB_DISC and HCP_Aging_DISC, with replication in UKB_REP and HCP_Aging_REP, is higher age consistently associated with higher default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for sex and cognition within each cohort?", "replication_cohorts": ["HCP_Aging_DISC", "UKB_REP", "HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "89c7369d95a294751cf5c375140d9d130dba267d6c01ae06bb839c019ab703a8", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "89c7369d95a294751cf5c375140d9d130dba267d6c01ae06bb839c019ab703a8", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_042", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "Across UKB_DISC and HCP_Aging_DISC, with replication in UKB_REP and HCP_Aging_REP, is higher age consistently associated with higher default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for sex and cognition within each cohort?", "question_sha256": "2cb2c4609cc1f908d14334e69dcc671acc108c0360972f04661b88c75498e664", "reference_id": "ncb-scientific-89c7369d95a29475", "scientific_core_sha256": "3d2c833ac496a8ad6c972dc1b558d6cca2aad67609de6432103383adee852e06", "semantic_cluster_id": "ncb-sem-e945cecc98941bef", "target_family": "normative_fmri", "task_ids": []}
{"aliases": ["ad_aging_q008"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-8c2247d3d87d1686", "benchmark_track": "scientific", "claim_uid": "ncb-claim-ea5b69566e8c504d", "contract": {"claim_id": "ad_aging_q008", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "smri_ventricles", "predictor": "beh_cdrsb", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is increasing clinical impairment from CN to MCI to Dementia associated with progressively higher smri_ventricles, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "8c2247d3d87d168619a886b699239573b6b6131b255047cbbae00c1b2219eece", "migration_status": "ambiguous_unresolved", "modality": "sMRI", "pre_v2_contract_sha256": "8c2247d3d87d168619a886b699239573b6b6131b255047cbbae00c1b2219eece", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q008", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is increasing clinical impairment from CN to MCI to Dementia associated with progressively higher smri_ventricles, adjusting for age and sex?", "question_sha256": "a9ce1aed49618cefa8a0a9a3605a1f166df666ddaa4aacc56fd3e053ed006fb4", "reference_id": "ncb-scientific-8c2247d3d87d1686", "scientific_core_sha256": "708b1f2a563ec2be779dbd5f05a8af37660f517ee81ac612497f130c32504f12", "semantic_cluster_id": "ncb-sem-ea5b69566e8c504d", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["asd_q008"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-8d7c71367a2043b9", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a44d2718db4923a4", "contract": {"claim_id": "asd_q008", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_HOLDOUT", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_HOLDOUT, does fc_between_network differ between ASD and HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_DISC", "ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "8d7c71367a2043b90fd51104e7c42a5e0fbd4068a2810fc8c3cbff83c8af75e6", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "8d7c71367a2043b90fd51104e7c42a5e0fbd4068a2810fc8c3cbff83c8af75e6", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q008", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE1_HOLDOUT, does fc_between_network differ between ASD and HC participants using dx as the predictor and no additional covariates?", "question_sha256": "b29948934ba0a84db7bb402482c14d92902908ec3ef781d63f7e22cb7ec73fac", "reference_id": "ncb-scientific-8d7c71367a2043b9", "scientific_core_sha256": "37bb2c7080e51844d479f9f7c868a2733e69e5715c9cd57c408cc19c7938e422", "semantic_cluster_id": "ncb-sem-a44d2718db4923a4", "target_family": "asd", "task_ids": ["ncb21-task-4a89eea2ea597161"]}
{"aliases": ["adhd_q024"], "alignment_disposition": "non_executable", "benchmark_case_id": "ncb-scientific-8d7fe2116b082179", "benchmark_track": "scientific", "claim_uid": "ncb-claim-e204539c7b009359", "contract": {"claim_id": "adhd_q024", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, does ADHD-inattentive type (dx=2) differ from ADHD-combined type (dx=1) in within-Default connectivity (fc_fc_Default_Default_z), with no additional covariates, and is the subtype contrast directionally consistent in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "8d7fe2116b0821799a9e992e61809bd3abcb212212e1521f1f163d3b6e9d3221", "migration_status": "non_executable", "modality": "fMRI-FC", "pre_v2_contract_sha256": "8d7fe2116b0821799a9e992e61809bd3abcb212212e1521f1f163d3b6e9d3221", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q024", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, does ADHD-inattentive type (dx=2) differ from ADHD-combined type (dx=1) in within-Default connectivity (fc_fc_Default_Default_z), with no additional covariates, and is the subtype contrast directionally consistent in ADHD200_REP?", "question_sha256": "aeccce9285a5097f95ce57237ebffd48df0ed40033cdb79a7c17d240f5e5978e", "reference_id": "ncb-scientific-8d7fe2116b082179", "scientific_core_sha256": "349494920ce88de4128b207b5a3c20cc7ad31ea24d5cf9afcf673f3753be289a", "semantic_cluster_id": "ncb-sem-e204539c7b009359", "target_family": "adhd", "task_ids": []}
{"aliases": ["psychosis_q016"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-9066c4a0d3bc2f9f", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a44d2718db4923a4", "contract": {"claim_id": "psychosis_q016", "covariates": ["age", "sex", "site"], "discovery_cohort": "COBRE_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_REP, do SZ and HC groups differ in fc_between_network in an unadjusted comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9066c4a0d3bc2f9f335adcc9e6fce3653c8c38198faedd03436f1aa34da54b25", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "9066c4a0d3bc2f9f335adcc9e6fce3653c8c38198faedd03436f1aa34da54b25", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q016", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In COBRE_REP, do SZ and HC groups differ in fc_between_network in an unadjusted comparison using dx as the only predictor and no covariates?", "question_sha256": "5b3efc83c2238eab3df9ed2b7c3e5db350519871fbc673eb52d4bdcd615604b3", "reference_id": "ncb-scientific-9066c4a0d3bc2f9f", "scientific_core_sha256": "b8816d7b8cba0591f711b2a1ef077b7ba86ef2516c8096b77eaf0c9a64bbc9e1", "semantic_cluster_id": "ncb-sem-a44d2718db4923a4", "target_family": "psychosis", "task_ids": ["ncb21-task-c356c0495b8f5c1e"]}
{"aliases": ["adhd_q040"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-909dd51daf957cf4", "benchmark_track": "scientific", "claim_uid": "ncb-claim-05af2046a1fc0188", "contract": {"claim_id": "adhd_q040", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered within-Salience/VentralAttention connectivity (fc_fc_SalVentAttn_SalVentAttn_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "909dd51daf957cf4b20c9b9653fa6fd59e0a164cd218cfc872a8413563b73c59", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "909dd51daf957cf4b20c9b9653fa6fd59e0a164cd218cfc872a8413563b73c59", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q040", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered within-Salience/VentralAttention connectivity (fc_fc_SalVentAttn_SalVentAttn_z), with no additional covariates?", "question_sha256": "30f9e44b2da47ffe1a7d08cf76441f598f9536fad52dabc91e41aedea32a9cd6", "reference_id": "ncb-scientific-909dd51daf957cf4", "scientific_core_sha256": "193ffb15e90e5254a64ed14d36ad3b2279d6e1e5a3aa8f85e29d64a39e22ad99", "semantic_cluster_id": "ncb-sem-05af2046a1fc0188", "target_family": "adhd", "task_ids": ["ncb21-task-76a0158c903db264"]}
{"aliases": ["adhd_q046"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-91575e683551f750", "benchmark_track": "scientific", "claim_uid": "ncb-claim-e5f15bfbf25f78f4", "contract": {"claim_id": "adhd_q046", "covariates": [], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": ["fc_fc_Cont_Default_z", "fc_fc_Cont_Default"], "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 2, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, does any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) relate more strongly to z-transformed Control-Default connectivity (fc_fc_Cont_Default_z) than to the corresponding untransformed measure (fc_fc_Cont_Default), using no additional covariates, and is the pattern checked in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 2, "selection": "preregistered"}}, "contract_sha256": "91575e683551f75081c4f506c9039447b9776b05e7c95ff1bf81a2323f0c51b9", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "91575e683551f75081c4f506c9039447b9776b05e7c95ff1bf81a2323f0c51b9", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q046", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, does any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) relate more strongly to z-transformed Control-Default connectivity (fc_fc_Cont_Default_z) than to the corresponding untransformed measure (fc_fc_Cont_Default), using no additional covariates, and is the pattern checked in ADHD200_REP?", "question_sha256": "5e68e8432ce7444392ec81f9d01c5b1f2d73c5553440f48dd91e84d651415103", "reference_id": "ncb-scientific-91575e683551f750", "scientific_core_sha256": "6d2541ee6dd8bf4afa27a8e154b7ab93c2e6c9948532754a5f049da9244adaa3", "semantic_cluster_id": "ncb-sem-e5f15bfbf25f78f4", "target_family": "adhd", "task_ids": ["ncb21-task-0b3199bf9e229ded"]}
{"aliases": ["psychosis_q024"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-9181e305d0e360a5", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a44d2718db4923a4", "contract": {"claim_id": "psychosis_q024", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_REP, do SZ and HC groups differ in fc_between_network in an unadjusted comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9181e305d0e360a5d17ec43febd9d32a46fc572a1fa87ab8680c7b4cb79abe90", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "9181e305d0e360a5d17ec43febd9d32a46fc572a1fa87ab8680c7b4cb79abe90", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q024", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In ChineseSZ_REP, do SZ and HC groups differ in fc_between_network in an unadjusted comparison using dx as the only predictor and no covariates?", "question_sha256": "13054da604d3991a2fb72837b3c7c4bcc617d91a730fe2a6dd173d5bd4704510", "reference_id": "ncb-scientific-9181e305d0e360a5", "scientific_core_sha256": "f9db43e6f72307ea7100188fa90179ca49373155e2ee2a9897a7dc46537b90b9", "semantic_cluster_id": "ncb-sem-a44d2718db4923a4", "target_family": "psychosis", "task_ids": ["ncb21-task-4500dc8037b51034"]}
{"aliases": ["age_dyno_ukb_hcpa"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-9211f485178e8764", "benchmark_track": "scientific", "claim_uid": "ncb-claim-897f4445da0cc6c8", "contract": {"claim_id": "age_dyno_ukb_hcpa", "covariates": ["sex", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_", "predictor": "age", "region_set": null, "type": "association", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For age association with fMRI dynamics descriptors in fMRI-dynamics, using UKB as discovery and HCP_Aging as replication, test the claim with expected direction two_sided and adjust for sex;site when available.", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "9211f485178e876413d000ae0d666f5eb21558c7ceb341bc2df9a556e8380671", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "9211f485178e876413d000ae0d666f5eb21558c7ceb341bc2df9a556e8380671", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Fjell and Walhovd 2010 review [VERIFY]", "source_collection": "legacy_scientific", "source_id": "age_dyno_ukb_hcpa", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "normative_fmri"}], "question": "For age association with fMRI dynamics descriptors in fMRI-dynamics, using UKB as discovery and HCP_Aging as replication, test the claim with expected direction two_sided and adjust for sex;site when available.", "question_sha256": "4aaab4ba4d4a98b5bd36ae35bbdec5d3dfc82b37a260be9e5768c51337b6cce3", "reference_id": "ncb-scientific-9211f485178e8764", "scientific_core_sha256": "a2d65fc3a0e90295fb4b24868529e27d20a43c3579c79212bdfa6548cef64fbc", "semantic_cluster_id": "ncb-sem-897f4445da0cc6c8", "target_family": "normative_fmri", "task_ids": []}
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{"aliases": ["normative_fmri_043"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-9b0372d2c93e148a", "benchmark_track": "scientific", "claim_uid": "ncb-claim-fd3ecc0a619d4345", "contract": {"claim_id": "normative_fmri_043", "covariates": ["sex", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across UKB_DISC and HCP_Aging_DISC, with replication in UKB_REP and HCP_Aging_REP, is higher age consistently associated with lower control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for sex and cognition within each cohort?", "replication_cohorts": ["HCP_Aging_DISC", "UKB_REP", "HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9b0372d2c93e148a55d818beea55e176baab43b6cdcbb1cadd346c4698342848", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "9b0372d2c93e148a55d818beea55e176baab43b6cdcbb1cadd346c4698342848", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_043", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "Across UKB_DISC and HCP_Aging_DISC, with replication in UKB_REP and HCP_Aging_REP, is higher age consistently associated with lower control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for sex and cognition within each cohort?", "question_sha256": "868ecfce7069e6184fb4dbbc39b5727b2c51dfc8894b61a8f3b86b72fc566327", "reference_id": "ncb-scientific-9b0372d2c93e148a", "scientific_core_sha256": "356b1798856b593f689a489edfc91e278981fb33c7b585cc052fed1815350cca", "semantic_cluster_id": "ncb-sem-fd3ecc0a619d4345", "target_family": "normative_fmri", "task_ids": []}
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{"aliases": ["asd_q018"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-9c2e4221cf5ca105", "benchmark_track": "scientific", "claim_uid": "ncb-claim-48f5ab47f50c688b", "contract": {"claim_id": "asd_q018", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Default", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Default differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9c2e4221cf5ca105c142aa03f1212934ddcc6f3a0b4ae66e5f9d130f892c1d68", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "9c2e4221cf5ca105c142aa03f1212934ddcc6f3a0b4ae66e5f9d130f892c1d68", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q018", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Default differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "ba928d407d1ca0f6c5afdaca542afb27bbb701df9518fa5bf8c117ed20911a6c", "reference_id": "ncb-scientific-9c2e4221cf5ca105", "scientific_core_sha256": "dc88b2e97bfd7ea2c0e87dbaf08c4f744bb24139ffef65d17071bf4fc4de52c2", "semantic_cluster_id": "ncb-sem-48f5ab47f50c688b", "target_family": "asd", "task_ids": ["ncb21-task-2ce25bc332b80d88"]}
{"aliases": ["pubmed_23333262_pmid23333262_rsfc_aging_1"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-9c418256797d0a86", "benchmark_track": "scientific", "claim_uid": "ncb-claim-4e67c2e3264a8958", "contract": {"claim_id": "pubmed_23333262_pmid23333262_rsfc_aging_1", "covariates": ["sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_", "predictor": "age", "region_set": "resting_state_functional_connectivity", "type": "association", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded age / older adults versus younger adults effect on resting-state functional connectivity in rs-fMRI / fMRI-FC, using ABCD as discovery and HCP_Aging as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "9c418256797d0a86064d970a3e88ff8457d32310776b1a8297e66c8a796c3e35", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "9c418256797d0a86064d970a3e88ff8457d32310776b1a8297e66c8a796c3e35", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:23333262; DOI:10.1016/j.neubiorev.2013.01.017", "source_collection": "stage2_current", "source_id": "pubmed_23333262_pmid23333262_rsfc_aging_1", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "For literature-grounded age / older adults versus younger adults effect on resting-state functional connectivity in rs-fMRI / fMRI-FC, using ABCD as discovery and HCP_Aging as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "question_sha256": "df99e81362b75dffbcbd07d8ee8f1a11c596fe3cb083ca887736f7d22a97e830", "reference_id": "ncb-scientific-9c418256797d0a86", "scientific_core_sha256": "6d9e05009d015781220d9a99c3dca3d7c4753d735161a846bcb46c27b1ecd554", "semantic_cluster_id": "ncb-sem-4e67c2e3264a8958", "target_family": "normative_fmri", "task_ids": ["ncb21-task-d3bbe5d9c3f53c79"]}
{"aliases": ["ad_brainwide_smri_adni_oasis3"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-9cb81ca19caf7d9d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-39943956b4ca7390", "contract": {"claim_id": "ad_brainwide_smri_adni_oasis3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": ["smri_hippocampus", "smri_wholebrain", "smri_entorhinal", "smri_fusiform", "smri_midtemp"], "predictor": "confirm_dx", "region_set": "ad_regional_atrophy_signature", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 5, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.6, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For AD regional atrophy signature in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 5, "selection": "preregistered"}}, "contract_sha256": "9cb81ca19caf7d9d6b49e500a49ea556a78744f64b6fd83c145fea8fe986637c", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "9cb81ca19caf7d9d6b49e500a49ea556a78744f64b6fd83c145fea8fe986637c", "provenance": [{"prior_label": "known_positive", "source_citation": "Jack et al. 2018 NIA-AA framework", "source_collection": "legacy_scientific", "source_id": "ad_brainwide_smri_adni_oasis3", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For AD regional atrophy signature in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "question_sha256": "97be5076603be9d917c886dc45ede9e795636baad44684b76a809bc66b0edc5c", "reference_id": "ncb-scientific-9cb81ca19caf7d9d", "scientific_core_sha256": "b163327a1cf450d5f3da5346f19f8b4715011e0094f8209838dfcb2ea37c9a64", "semantic_cluster_id": "ncb-sem-39943956b4ca7390", "target_family": "ad_aging", "task_ids": ["ncb21-task-47e6d67533617281"]}
{"aliases": ["psychosis_q027"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-9eaf2a23ddb73ea3", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2166e66544e56e96", "contract": {"claim_id": "psychosis_q027", "covariates": ["age", "sex", "site"], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In FBIRN_DISC, is fc_within_network lower in SZ than HC in an unadjusted comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9eaf2a23ddb73ea3b9ad8419cc764b871d15a798fea17ac3a71821704466415e", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "9eaf2a23ddb73ea3b9ad8419cc764b871d15a798fea17ac3a71821704466415e", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q027", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In FBIRN_DISC, is fc_within_network lower in SZ than HC in an unadjusted comparison with dx as the only predictor and no covariates?", "question_sha256": "b278ca421543844fa380ea4735c7f7b3cc5a775f453e6281dd449682d6ea98fa", "reference_id": "ncb-scientific-9eaf2a23ddb73ea3", "scientific_core_sha256": "11cb39da8a64e2be9e6096cba334e0ce56565619423b10be8e5cc6fdae7fca4b", "semantic_cluster_id": "ncb-sem-2166e66544e56e96", "target_family": "psychosis", "task_ids": ["ncb21-task-5dcad199cd3ebbe8"]}
{"aliases": ["adhd_q001"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-9ec4c7f2ec1fad99", "benchmark_track": "scientific", "claim_uid": "ncb-claim-d6fdc1c9578b0a3a", "contract": {"claim_id": "adhd_q001", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ABCD_DISC, excluding participants with missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with lower Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z), with no additional covariates, and does the same direction appear in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9ec4c7f2ec1fad994bbafcb3d8260862dc2d3b5829226c0f0c4ea111889d1c08", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "9ec4c7f2ec1fad994bbafcb3d8260862dc2d3b5829226c0f0c4ea111889d1c08", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q001", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC, excluding participants with missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with lower Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z), with no additional covariates, and does the same direction appear in ABCD_REP?", "question_sha256": "0f3cb7e08cf79f5f578777c344fa64211184f4044949e50c9edc1ad14aa1eb54", "reference_id": "ncb-scientific-9ec4c7f2ec1fad99", "scientific_core_sha256": "f0afbb20ed1fa01f3bd10c7dcee0bb501d98f39a5aebaf7a9283bdee421d2ace", "semantic_cluster_id": "ncb-sem-d6fdc1c9578b0a3a", "target_family": "adhd", "task_ids": ["ncb21-task-d1b98a4ced7af402"]}
{"aliases": ["adhd_q011"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-9f890b1a7a66889e", "benchmark_track": "scientific", "claim_uid": "ncb-claim-e5afc4f4b28405cf", "contract": {"claim_id": "adhd_q011", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with lower Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z), with no additional covariates, and does this replicate in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9f890b1a7a66889eb010dc6a885fa8ac58380191f9b86429c8ce90076d63edcc", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "9f890b1a7a66889eb010dc6a885fa8ac58380191f9b86429c8ce90076d63edcc", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q011", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with lower Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z), with no additional covariates, and does this replicate in ADHD200_REP?", "question_sha256": "c11760e2e99fad3c8987f0d164fa3e1e8cf068f32903786dee358c5ac5fa3e3f", "reference_id": "ncb-scientific-9f890b1a7a66889e", "scientific_core_sha256": "00d428b15dc44048adc2302643c49308366369bc943ac4534c312ccbd180391b", "semantic_cluster_id": "ncb-sem-e5afc4f4b28405cf", "target_family": "adhd", "task_ids": ["ncb21-task-5cac938d3c79d8d8"]}
{"aliases": ["asd_q029"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-a02841671504d8cd", "benchmark_track": "scientific", "claim_uid": "ncb-claim-0beda20d705c4856", "contract": {"claim_id": "asd_q029", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_Limbic", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Limbic_Limbic differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a02841671504d8cd91f7002bbbc87782b0cb75c4c91c3c75f40930bf0fc27467", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "a02841671504d8cd91f7002bbbc87782b0cb75c4c91c3c75f40930bf0fc27467", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q029", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Limbic_Limbic differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "cbd2d211c6dc6de80c4b9f18ade9709f22962b3b4c1fb13e66f334359e7003ef", "reference_id": "ncb-scientific-a02841671504d8cd", "scientific_core_sha256": "5293f7fc3fbd61338fa219ef1478adf4aa6b2fab233abcddcc55abe72e446a44", "semantic_cluster_id": "ncb-sem-0beda20d705c4856", "target_family": "asd", "task_ids": ["ncb21-task-b95b16ef9794f281"]}
{"aliases": ["normative_fmri_002"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-a1bf69b8f56d46c9", "benchmark_track": "scientific", "claim_uid": "ncb-claim-489bd403d62f2366", "contract": {"claim_id": "normative_fmri_002", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a1bf69b8f56d46c996f93349f5201c8b628f7dd5753a9899ff61c78ed977e658", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "a1bf69b8f56d46c996f93349f5201c8b628f7dd5753a9899ff61c78ed977e658", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_002", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for sex and cognition?", "question_sha256": "f690472eed97befcc9498b6fe58120bdca883a9b7f7d01b8fba12785a7380316", "reference_id": "ncb-scientific-a1bf69b8f56d46c9", "scientific_core_sha256": "b43571193e81375c0c3af3ac486953b78dacf81830926396d76dba702060446f", "semantic_cluster_id": "ncb-sem-489bd403d62f2366", "target_family": "normative_fmri", "task_ids": ["ncb21-task-6959208181ee6072"]}
{"aliases": ["psychosis_q049"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-a1da46d7f5fa792d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-0de9c0c5b4d3defc", "contract": {"claim_id": "psychosis_q049", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across the four discovery cohorts BSNIP2_DISC, COBRE_DISC, ChineseSZ_DISC, and FBIRN_DISC, is SZ associated with lower fc_mean_positive than HC in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["COBRE_DISC", "ChineseSZ_DISC", "FBIRN_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a1da46d7f5fa792d06b40ef905be2163aa10371959c82a12774363e09e80a844", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "a1da46d7f5fa792d06b40ef905be2163aa10371959c82a12774363e09e80a844", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q049", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "Across the four discovery cohorts BSNIP2_DISC, COBRE_DISC, ChineseSZ_DISC, and FBIRN_DISC, is SZ associated with lower fc_mean_positive than HC in unadjusted dx-only comparisons with no covariates?", "question_sha256": "849940a6d905eab0f21abc57eb9b71c66c1e25ab1c5041d6406fb28becad517a", "reference_id": "ncb-scientific-a1da46d7f5fa792d", "scientific_core_sha256": "f6ee386d644bb4c0c9961d4f1d7d079e252374a9933464dbfaf0059653711304", "semantic_cluster_id": "ncb-sem-0de9c0c5b4d3defc", "target_family": "psychosis", "task_ids": ["ncb21-task-eb68dfa2754f1db6"]}
{"aliases": ["ad_midtemp_atrophy_adni_oasis3"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-a20d5751ea756186", "benchmark_track": "scientific", "claim_uid": "ncb-claim-5ec25f86a95995a3", "contract": {"claim_id": "ad_midtemp_atrophy_adni_oasis3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_midtemp", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For AD middle temporal atrophy in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a20d5751ea756186d20b808bb6f95bf13e0bc956ea37bccdfd0404d9233947ed", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "a20d5751ea756186d20b808bb6f95bf13e0bc956ea37bccdfd0404d9233947ed", "provenance": [{"prior_label": "known_positive", "source_citation": "Jack et al. 2018 Alzheimer's & Dementia", "source_collection": "legacy_scientific", "source_id": "ad_midtemp_atrophy_adni_oasis3", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For AD middle temporal atrophy in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "question_sha256": "27b894055f88f8bc33ad7398a202e6882cd2c1be7d493aa9dceb5843f2db3ff2", "reference_id": "ncb-scientific-a20d5751ea756186", "scientific_core_sha256": "4f22eb39dbbd4c8a46fa72c57641762827f42d7e6850cffa6e200dddec96434b", "semantic_cluster_id": "ncb-sem-5ec25f86a95995a3", "target_family": "ad_aging", "task_ids": ["ncb21-task-03389888b8f63226"]}
{"aliases": ["ad_fdg_hypometabolism_adni"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-a36ed4355870c674", "benchmark_track": "scientific", "claim_uid": "ncb-claim-cf0eadfce7fc0fa3", "contract": {"claim_id": "ad_fdg_hypometabolism_adni", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "pet_fdg_suvr", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For AD FDG hypometabolism in PET, using ADNI as discovery, test the claim with expected direction negative and adjust for age;sex when available.", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a36ed4355870c67495b9c1642246c88e628f924a40b61dcf3dc95742bd0f7c0b", "migration_status": "ready", "modality": "PET", "pre_v2_contract_sha256": "a36ed4355870c67495b9c1642246c88e628f924a40b61dcf3dc95742bd0f7c0b", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "provisional", "source_collection": "legacy_scientific", "source_id": "ad_fdg_hypometabolism_adni", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For AD FDG hypometabolism in PET, using ADNI as discovery, test the claim with expected direction negative and adjust for age;sex when available.", "question_sha256": "56be5325b4e73bd57c10e849d6dab1725eff973e263b44fe8b6aa56c29fe3547", "reference_id": "ncb-scientific-a36ed4355870c674", "scientific_core_sha256": "331c26efa5688b437e6263e8f8e0a90dfcd67164a28ad459d05962ee91067e36", "semantic_cluster_id": "ncb-sem-cf0eadfce7fc0fa3", "target_family": "ad_aging", "task_ids": ["ncb21-task-06ebe3ba5846d880"]}
{"aliases": ["ad_aging_q048"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-a3f4263a0dce56cf", "benchmark_track": "scientific", "claim_uid": "ncb-claim-ba2b48484a525868", "contract": {"claim_id": "ad_aging_q048", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADNI_fMRI_REP", "estimand": {"direction": "negative", "group": {"case": "2.0", "control": "0.0", "var": "dx"}, "outcome": "fc_fc_Cont_Default_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx in [\"0.0\", \"2.0\"]", "question": "In ADNI_fMRI_REP, excluding participants with missing diagnosis code, is diagnosis code 2.0 associated with lower fc_fc_Cont_Default_z than diagnosis code 0.0, adjusting for age and sex?", "replication_cohorts": [], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a3f4263a0dce56cf738ebd2d271cf2f786acf25f6ab1432a96784f063e51d349", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "a3f4263a0dce56cf738ebd2d271cf2f786acf25f6ab1432a96784f063e51d349", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q048", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_fMRI_REP, excluding participants with missing diagnosis code, is diagnosis code 2.0 associated with lower fc_fc_Cont_Default_z than diagnosis code 0.0, adjusting for age and sex?", "question_sha256": "19e071037357ceedd8222b71e868797a6a5d8c0b0fc9a3c80412e3c081ee348c", "reference_id": "ncb-scientific-a3f4263a0dce56cf", "scientific_core_sha256": "6190d6f1f378f912d39fce6d19e77354cd41bebe544e8e3e26d2ffb71a0cacc1", "semantic_cluster_id": "ncb-sem-ba2b48484a525868", "target_family": "ad_aging", "task_ids": ["ncb21-task-fd6e517ddccfca52"]}
{"aliases": ["normative_fmri_027"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-a427d5471566b2cf", "benchmark_track": "scientific", "claim_uid": "ncb-claim-f6cad41f7540de84", "contract": {"claim_id": "normative_fmri_027", "covariates": ["age", "sex", "site"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, is higher cognition associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and sex?", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a427d5471566b2cf475103489cde2f05ea57bbab09ea9cdd585ccf3a09b6dc00", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "a427d5471566b2cf475103489cde2f05ea57bbab09ea9cdd585ccf3a09b6dc00", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_027", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, is higher cognition associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and sex?", "question_sha256": "a41420f536f7714287e4dfce224f39ed0adc6ad4ae0bd1571069678cda9ee1ba", "reference_id": "ncb-scientific-a427d5471566b2cf", "scientific_core_sha256": "9909e5d6fa1fb30b43617472f134386b76565f1092f7b928b667f8782abe8313", "semantic_cluster_id": "ncb-sem-f6cad41f7540de84", "target_family": "normative_fmri", "task_ids": ["ncb21-task-28a263d013fa1b7a"]}
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{"aliases": ["asd_q031"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-a7bd041be62e2db4", "benchmark_track": "scientific", "claim_uid": "ncb-claim-c1015aaf0f628f94", "contract": {"claim_id": "asd_q031", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Limbic_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a7bd041be62e2db43aded1d76a6c0b581c7274b1f519b9d483c62e6dc39f3136", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "a7bd041be62e2db43aded1d76a6c0b581c7274b1f519b9d483c62e6dc39f3136", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q031", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Limbic_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "3e5de38ee0c91ab4b8c978611368431913f9e80f1d93980483df61e2376788ce", "reference_id": "ncb-scientific-a7bd041be62e2db4", "scientific_core_sha256": "3714a41f633c1dc72807b8c293ed5379671b1fd549f8f1ef207a511c1177c621", "semantic_cluster_id": "ncb-sem-c1015aaf0f628f94", "target_family": "asd", "task_ids": ["ncb21-task-b44a4ec14f918682"]}
{"aliases": ["normative_fmri_007"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-a9e0ba33a876abc0", "benchmark_track": "scientific", "claim_uid": "ncb-claim-ec08872e19a717ae", "contract": {"claim_id": "normative_fmri_007", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_SomMot_SomMot_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower somatomotor within-network connectivity (fc_fc_SomMot_SomMot_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a9e0ba33a876abc0fa6cbc657ebbfa5b3516bdf998288dcb9ea497f1dd12cfda", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "a9e0ba33a876abc0fa6cbc657ebbfa5b3516bdf998288dcb9ea497f1dd12cfda", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_007", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower somatomotor within-network connectivity (fc_fc_SomMot_SomMot_z), adjusting for sex and cognition?", "question_sha256": "633cfc5e33b7c5e69d55f47588bbc479674deee1e1de7216ce7490d6119c6bc2", "reference_id": "ncb-scientific-a9e0ba33a876abc0", "scientific_core_sha256": "42753116d455ebd0fa4e5f85e303ac4e3504e22301918cfa510a3edcb016fc51", "semantic_cluster_id": "ncb-sem-ec08872e19a717ae", "target_family": "normative_fmri", "task_ids": ["ncb21-task-c781fd15ae8248cb"]}
{"aliases": ["normative_fmri_005"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-acb1371a4d55e5b6", "benchmark_track": "scientific", "claim_uid": "ncb-claim-44eddefc96bcba31", "contract": {"claim_id": "normative_fmri_005", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Default_SalVentAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with higher connectivity between default-mode and salience/ventral-attention networks (fc_fc_Default_SalVentAttn_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "acb1371a4d55e5b67d2d06ead7f73f437ea8d35c88a4fe46cbd67148b6955944", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "acb1371a4d55e5b67d2d06ead7f73f437ea8d35c88a4fe46cbd67148b6955944", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_005", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with higher connectivity between default-mode and salience/ventral-attention networks (fc_fc_Default_SalVentAttn_z), adjusting for sex and cognition?", "question_sha256": "0f95eab306534d82d2c25aa789d7b0145508c7161412e1c1a7dc75893a845bfc", "reference_id": "ncb-scientific-acb1371a4d55e5b6", "scientific_core_sha256": "1bed342b372aa99d3734ec9faa91e63156571e9cc04e9d6ed6d92ce916f3c947", "semantic_cluster_id": "ncb-sem-44eddefc96bcba31", "target_family": "normative_fmri", "task_ids": ["ncb21-task-31b5436965a2340b"]}
{"aliases": ["adhd_q045"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-ad793f2b627c14db", "benchmark_track": "scientific", "claim_uid": "ncb-claim-5b1663a8a741ec6a", "contract": {"claim_id": "adhd_q045", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 2, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ABCD_DISC, excluding missing dx, does ADHD status (dx=1.0 vs dx=0.0) relate more strongly to z-transformed Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z) than to the corresponding untransformed measure (fc_fc_Default_DorsAttn), using no additional covariates, and is the pattern checked in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 2, "selection": "preregistered"}}, "contract_sha256": "ad793f2b627c14db9571a23bc5ff054129a8af48d092cae596e02c3fbd8ca3e6", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "ad793f2b627c14db9571a23bc5ff054129a8af48d092cae596e02c3fbd8ca3e6", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q045", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC, excluding missing dx, does ADHD status (dx=1.0 vs dx=0.0) relate more strongly to z-transformed Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z) than to the corresponding untransformed measure (fc_fc_Default_DorsAttn), using no additional covariates, and is the pattern checked in ABCD_REP?", "question_sha256": "33e67a6ff2acbae4b2f86b6e1a721f1a0793bf70a93436104c7373d2e22cd7fe", "reference_id": "ncb-scientific-ad793f2b627c14db", "scientific_core_sha256": "5ccabb2b1b83d654a34e15df1e775980cf51bea7afdf0ad9a4bcf9ecf3f122e9", "semantic_cluster_id": "ncb-sem-5b1663a8a741ec6a", "target_family": "adhd", "task_ids": []}
{"aliases": ["asd_q013"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-adc64a42191e17f6", "benchmark_track": "scientific", "claim_uid": "ncb-claim-33511e0d8cad530d", "contract": {"claim_id": "asd_q013", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_DorsAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_DorsAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "adc64a42191e17f63007bc25281becbf3d5835b1b4907a7c66c7d4875362948d", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "adc64a42191e17f63007bc25281becbf3d5835b1b4907a7c66c7d4875362948d", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q013", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_DorsAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "778579800099c6d585924c98ec2c69a59dc9d6efc8ba7243193d1f06716cbf15", "reference_id": "ncb-scientific-adc64a42191e17f6", "scientific_core_sha256": "f1876c5eb00f38c0b40e8f20d71439c9cf3fea6934ecb2815658418beecd51ce", "semantic_cluster_id": "ncb-sem-33511e0d8cad530d", "target_family": "asd", "task_ids": ["ncb21-task-8c1c0d2918c17a43"]}
{"aliases": ["normative_fmri_044"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-adc7daee506cca47", "benchmark_track": "scientific", "claim_uid": "ncb-claim-92c42c52b1e6d472", "contract": {"claim_id": "normative_fmri_044", "covariates": ["age", "sex", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "phen_fluid_intelligence", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across UKB_DISC and HCP_Aging_DISC, with replication in UKB_REP and HCP_Aging_REP, is higher cognition consistently associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and sex within each cohort?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "adc7daee506cca470db321582aa77b9cc0e7f2abd527b99d4738e32de92f9075", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "adc7daee506cca470db321582aa77b9cc0e7f2abd527b99d4738e32de92f9075", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_044", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "Across UKB_DISC and HCP_Aging_DISC, with replication in UKB_REP and HCP_Aging_REP, is higher cognition consistently associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and sex within each cohort?", "question_sha256": "ae80a32cb010bf73a15d6e0b95b5781a5be2e6ad296977d2d8502fed1bfd1f30", "reference_id": "ncb-scientific-adc7daee506cca47", "scientific_core_sha256": "a501cadecf3537472a14dd8e5597b357d3aba9a891ffccba9c148e05f9c678c5", "semantic_cluster_id": "ncb-sem-92c42c52b1e6d472", "target_family": "normative_fmri", "task_ids": []}
{"aliases": ["asd_q046"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-afbfd52ab898aa8b", "benchmark_track": "scientific", "claim_uid": "ncb-claim-01b92be6f309d0ae", "contract": {"claim_id": "asd_q046", "covariates": [], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Default_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "afbfd52ab898aa8b75058616b6193b34892bea7f7d452244ed64defafeede78a", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "afbfd52ab898aa8b75058616b6193b34892bea7f7d452244ed64defafeede78a", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q046", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Default_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "8f745d620c26413a8472bc7517e775687522b7c7596773a1a7f081b30a404033", "reference_id": "ncb-scientific-afbfd52ab898aa8b", "scientific_core_sha256": "e44382c288c683f79d9c5767662cd33a846b2da4c2bff27e709331296bd054f8", "semantic_cluster_id": "ncb-sem-01b92be6f309d0ae", "target_family": "asd", "task_ids": ["ncb21-task-b4d563d354061986"]}
{"aliases": ["adhd_q020"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-afe1f83e3d954a8c", "benchmark_track": "scientific", "claim_uid": "ncb-claim-dfdb03eae900b7ea", "contract": {"claim_id": "adhd_q020", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SomMot_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with higher Somatomotor-Somatomotor connectivity (fc_fc_SomMot_SomMot_z), with no additional covariates, and is this direction seen in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "afe1f83e3d954a8cea0ae7eceea167af281c6ea8ddce2bc289e93500d6ac2e54", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "afe1f83e3d954a8cea0ae7eceea167af281c6ea8ddce2bc289e93500d6ac2e54", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q020", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with higher Somatomotor-Somatomotor connectivity (fc_fc_SomMot_SomMot_z), with no additional covariates, and is this direction seen in ADHD200_REP?", "question_sha256": "a6ebc92d75b1dd68107aaeb8a568c0d613fd38e1bbdd8f91cc7a0013c56d912b", "reference_id": "ncb-scientific-afe1f83e3d954a8c", "scientific_core_sha256": "6d7912e2d75b61ecfe93389a8b5b1de017f7406766c9a73fe91b8266b2d28976", "semantic_cluster_id": "ncb-sem-dfdb03eae900b7ea", "target_family": "adhd", "task_ids": ["ncb21-task-cacb3bd51f7eea36"]}
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{"aliases": ["brain_aging_hippocampus_adni_oasis3_cn"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-b22524a12bd4a0b9", "benchmark_track": "scientific", "claim_uid": "ncb-claim-f3e4911f433998d2", "contract": {"claim_id": "brain_aging_hippocampus_adni_oasis3_cn", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_hippocampus", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "For brain aging hippocampal atrophy in CN adults in sMRI, using ADNI_CN as discovery and OASIS3_CN as replication, test the claim with expected direction negative and adjust for sex;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "b22524a12bd4a0b93a1526df97ea32199d9f08beef37d943ae1d4f7942ff7f5b", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "b22524a12bd4a0b93a1526df97ea32199d9f08beef37d943ae1d4f7942ff7f5b", "provenance": [{"prior_label": "known_positive", "source_citation": "Fjell and Walhovd 2010 Reviews in the Neurosciences", "source_collection": "legacy_scientific", "source_id": "brain_aging_hippocampus_adni_oasis3_cn", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "ad_aging"}], "question": "For brain aging hippocampal atrophy in CN adults in sMRI, using ADNI_CN as discovery and OASIS3_CN as replication, test the claim with expected direction negative and adjust for sex;eTIV when available.", "question_sha256": "5942338980a08aaa9cf5e973661fe3df2a80114b60ce0dee3ca67136ccb9b2ba", "reference_id": "ncb-scientific-b22524a12bd4a0b9", "scientific_core_sha256": "48fe341ebfe1749a66fa45d30b851fb60d4cfa44272f1de27e7ba3c8f0c6d8cc", "semantic_cluster_id": "ncb-sem-f3e4911f433998d2", "target_family": "ad_aging", "task_ids": ["ncb21-task-6110eb85e2d7580c"]}
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{"aliases": ["normative_fmri_018"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-bc6d05b49560e9df", "benchmark_track": "scientific", "claim_uid": "ncb-claim-ea2068ac2f31ae27", "contract": {"claim_id": "normative_fmri_018", "covariates": ["age", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_SalVentAttn_SalVentAttn_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, do females and males differ in salience/ventral-attention within-network connectivity (fc_fc_SalVentAttn_SalVentAttn_z), adjusting for age and cognition?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bc6d05b49560e9df556c27a32ce7b1ba5f9f2ef45e09a11867a8804906ed9dcf", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "bc6d05b49560e9df556c27a32ce7b1ba5f9f2ef45e09a11867a8804906ed9dcf", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_018", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In HCP_DISC, with replication in HCP_REP, do females and males differ in salience/ventral-attention within-network connectivity (fc_fc_SalVentAttn_SalVentAttn_z), adjusting for age and cognition?", "question_sha256": "dee65f72a47aff4d0e1ccbb29ba0c69bb7893bc2d8fbf51e2549b1c4bcdcbaa5", "reference_id": "ncb-scientific-bc6d05b49560e9df", "scientific_core_sha256": "b004c255aa05390f098fb8b1cf40293d5b8f8a7644484f581710a21cd45094bf", "semantic_cluster_id": "ncb-sem-ea2068ac2f31ae27", "target_family": "normative_fmri", "task_ids": ["ncb21-task-2a7a3de6b7d503b4"]}
{"aliases": ["ad_aging_q021"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-bd78b101a1f87be6", "benchmark_track": "scientific", "claim_uid": "ncb-claim-d295d09b83e74459", "contract": {"claim_id": "ad_aging_q021", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_hippocampus", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with lower smri_hippocampus than CN, adjusting for age and sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bd78b101a1f87be6fe2c3e88d31dc8e50bef5aafe3295b714c8df459f8c341e0", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "bd78b101a1f87be6fe2c3e88d31dc8e50bef5aafe3295b714c8df459f8c341e0", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q021", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with lower smri_hippocampus than CN, adjusting for age and sex?", "question_sha256": "ede7da991590f91e4bbee4c1cb0c6aec50937e0298fdeefea66c0e15a76c71b7", "reference_id": "ncb-scientific-bd78b101a1f87be6", "scientific_core_sha256": "967b36b83187dc88df269ee0933d9e7ff8768454244e7a8113d4fa3d2f411668", "semantic_cluster_id": "ncb-sem-d295d09b83e74459", "target_family": "ad_aging", "task_ids": ["ncb21-task-76fc7b6b4604ef89"]}
{"aliases": ["pubmed_21729419_pmid21729419_1"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-bdabe2252485052d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-35760c43a2264071", "contract": {"claim_id": "pubmed_21729419_pmid21729419_1", "covariates": ["age", "eTIV", "sex"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_", "predictor": "confirm_dx", "region_set": "smri", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "eTIV", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 6, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded clinical dementia diagnosis or dementia-related disease group effect on regional/global cortical atrophy in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction positive and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 6, "selection": "preregistered"}}, "contract_sha256": "bdabe2252485052d7dc57af8fa2e2b0c2ff1a6f8ceb218cf47d53bc6ff965cdd", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "bdabe2252485052d7dc57af8fa2e2b0c2ff1a6f8ceb218cf47d53bc6ff965cdd", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:21729419; DOI:10.1017/S1041610211000913", "source_collection": "stage2_current", "source_id": "pubmed_21729419_pmid21729419_1", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "For literature-grounded clinical dementia diagnosis or dementia-related disease group effect on regional/global cortical atrophy in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction positive and adjust for age;eTIV;sex when available.", "question_sha256": "afdd0d516b0e02ac11ff3e32a5a41532121f371c8b0d407f13ce0e2c6f41a3af", "reference_id": "ncb-scientific-bdabe2252485052d", "scientific_core_sha256": "29980e4edc1ac46d117411d465e4ad43940dcb1be6bc2c4567f937bab48780ea", "semantic_cluster_id": "ncb-sem-35760c43a2264071", "target_family": "ad_aging", "task_ids": ["ncb21-task-57c0fb95d68b794c"]}
{"aliases": ["adhd_q009"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-bdc24737aa23b682", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a93e2fa433789220", "contract": {"claim_id": "adhd_q009", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered Limbic-Salience/VentralAttention connectivity (fc_fc_Limbic_SalVentAttn_z), with no additional covariates, and does the association replicate in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bdc24737aa23b68213ee1a77d82e33597f5039ce548624b69e5675e7b1b02b18", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "bdc24737aa23b68213ee1a77d82e33597f5039ce548624b69e5675e7b1b02b18", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q009", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered Limbic-Salience/VentralAttention connectivity (fc_fc_Limbic_SalVentAttn_z), with no additional covariates, and does the association replicate in ABCD_REP?", "question_sha256": "19f7933999dbf034aab1cba658fd2ba657b5373ecc87b7b0805823638f64981a", "reference_id": "ncb-scientific-bdc24737aa23b682", "scientific_core_sha256": "b4d5415534cce368be98149cf72e0a4b63cabf56605c95d53afa73d2cf9a1d1f", "semantic_cluster_id": "ncb-sem-a93e2fa433789220", "target_family": "adhd", "task_ids": ["ncb21-task-2de1487414a9935d"]}
{"aliases": ["adhd_q016"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-bdd01753f9ebb90c", "benchmark_track": "scientific", "claim_uid": "ncb-claim-01555b96f5ff8e0a", "contract": {"claim_id": "adhd_q016", "covariates": [], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with lower Control-DorsalAttention connectivity (fc_fc_Cont_DorsAttn_z), with no additional covariates, and is this direction replicated in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bdd01753f9ebb90c217a505dcc5198d851aee4b3c3450e682d1615f35e5dd44c", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "bdd01753f9ebb90c217a505dcc5198d851aee4b3c3450e682d1615f35e5dd44c", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q016", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with lower Control-DorsalAttention connectivity (fc_fc_Cont_DorsAttn_z), with no additional covariates, and is this direction replicated in ADHD200_REP?", "question_sha256": "c0c3136ae13104aee5f285b829af93f0169b1b014dbf9d271372f37ae8fa88ae", "reference_id": "ncb-scientific-bdd01753f9ebb90c", "scientific_core_sha256": "3c4e0dd4c3da2ffbbe9f17a1ccfe1369e3536e836b048d0b1367da3b5ba30254", "semantic_cluster_id": "ncb-sem-01555b96f5ff8e0a", "target_family": "adhd", "task_ids": ["ncb21-task-d6d1c76b3d01b0bd"]}
{"aliases": ["ad_aging_q007"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-be6c2a9394bf0498", "benchmark_track": "scientific", "claim_uid": "ncb-claim-c7d492887bd930e8", "contract": {"claim_id": "ad_aging_q007", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_hippocampus", "predictor": "beh_cdrsb", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is increasing clinical impairment from CN to MCI to Dementia associated with progressively lower smri_hippocampus, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "be6c2a9394bf0498514b7f9b8a7c090d0eecae63bc6a4851a3b2daab83152219", "migration_status": "ambiguous_unresolved", "modality": "sMRI", "pre_v2_contract_sha256": "be6c2a9394bf0498514b7f9b8a7c090d0eecae63bc6a4851a3b2daab83152219", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q007", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is increasing clinical impairment from CN to MCI to Dementia associated with progressively lower smri_hippocampus, adjusting for age and sex?", "question_sha256": "10c81700d8723ab87ddfb3fe5342761a768d8bf9c254994d5b9db9c5f2661c95", "reference_id": "ncb-scientific-be6c2a9394bf0498", "scientific_core_sha256": "2edb5d8fa5b83c1c9db42020a371ebda6135c3cfc6a2842f86f95593b4193e38", "semantic_cluster_id": "ncb-sem-c7d492887bd930e8", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["asd_q049"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-be9238714808b664", "benchmark_track": "scientific", "claim_uid": "ncb-claim-63f13b156feb0458", "contract": {"claim_id": "asd_q049", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_SalVentAttn_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "be9238714808b66402159f2c45825993dd00eadd147b39f453e2e7e450668e79", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "be9238714808b66402159f2c45825993dd00eadd147b39f453e2e7e450668e79", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q049", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_SalVentAttn_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "b3fa42d2a630ebc3caa7c74fb7cbd7662c049cc3c860cb5ce03902ac58d726a8", "reference_id": "ncb-scientific-be9238714808b664", "scientific_core_sha256": "f4f5fce5721cac343ee2ceb3ff15aaf6f61f515a0a4ed97faeb874be0e847473", "semantic_cluster_id": "ncb-sem-63f13b156feb0458", "target_family": "asd", "task_ids": ["ncb21-task-ceeb9f8bb890690b"]}
{"aliases": ["ad_aging_q029"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-bf6a4a4dabf8357f", "benchmark_track": "scientific", "claim_uid": "ncb-claim-35771173cccac1ce", "contract": {"claim_id": "ad_aging_q029", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_wholebrain", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In OASIS3_DISC, among CN participants, is older age associated with lower smri_wholebrain, adjusting for sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bf6a4a4dabf8357f31e6a07ae1504771c332c4ed81929fb895a09609631d5866", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "bf6a4a4dabf8357f31e6a07ae1504771c332c4ed81929fb895a09609631d5866", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q029", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In OASIS3_DISC, among CN participants, is older age associated with lower smri_wholebrain, adjusting for sex?", "question_sha256": "471346971a5ea41cfb190c9fabcbd47a7800e7ac5bf957af51dac02889ff6aba", "reference_id": "ncb-scientific-bf6a4a4dabf8357f", "scientific_core_sha256": "5431056f103431ae8623f219ada1d4abec04b25cb89eaceb664b3c61380a9985", "semantic_cluster_id": "ncb-sem-35771173cccac1ce", "target_family": "ad_aging", "task_ids": ["ncb21-task-fb80325a3bdd78f7"]}
{"aliases": ["pubmed_34183210_pmid34183210_1"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-c1112f228bb27f06", "benchmark_track": "scientific", "claim_uid": "ncb-claim-19a40eeeb50e9d61", "contract": {"claim_id": "pubmed_34183210_pmid34183210_1", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": "fMRI-FC", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded breakthrough psychosis relapse on ongoing antipsychotic maintenance vs healthy controls effect on striatal resting-state functional connectivity / striatal connectivity index in fMRI-FC, using BSNIP2 as discovery and COBRE as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c1112f228bb27f06f18f32376d89a4b816fcc7df2f53487617d65faedc726ef5", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "c1112f228bb27f06f18f32376d89a4b816fcc7df2f53487617d65faedc726ef5", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:34183210; DOI:10.1016/j.schres.2021.06.010", "source_collection": "stage2_current", "source_id": "pubmed_34183210_pmid34183210_1", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "For literature-grounded breakthrough psychosis relapse on ongoing antipsychotic maintenance vs healthy controls effect on striatal resting-state functional connectivity / striatal connectivity index in fMRI-FC, using BSNIP2 as discovery and COBRE as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "question_sha256": "3e8049b7ffb2a51555b02995586bc5ac758cba8fc9b0e435c93488e887e2ff70", "reference_id": "ncb-scientific-c1112f228bb27f06", "scientific_core_sha256": "13f948aa9761a6df676c1a656b12123f767ca72101992773231b95bb65b418b7", "semantic_cluster_id": "ncb-sem-19a40eeeb50e9d61", "target_family": "psychosis", "task_ids": []}
{"aliases": ["normative_fmri_033"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-c1b8f2bee08cd388", "benchmark_track": "scientific", "claim_uid": "ncb-claim-5963ec53b7af56d7", "contract": {"claim_id": "normative_fmri_033", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher age associated with lower default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for sex and cognition?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c1b8f2bee08cd3885ae393bad4189abe4f6f306525a43073ef666674c49e6e5a", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "c1b8f2bee08cd3885ae393bad4189abe4f6f306525a43073ef666674c49e6e5a", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_033", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher age associated with lower default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for sex and cognition?", "question_sha256": "bbb2f5d0337d98ca21d01363117c8802166d00564d52138fc36095d6b7896a14", "reference_id": "ncb-scientific-c1b8f2bee08cd388", "scientific_core_sha256": "8c0792a412bce1cdbee17765d082e161d376aeeb834a9e479c512f09a5e9ac72", "semantic_cluster_id": "ncb-sem-5963ec53b7af56d7", "target_family": "normative_fmri", "task_ids": ["ncb21-task-0244deeb8ae44e7b"]}
{"aliases": ["ad_aging_q018"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-c2b02d58d24ba60d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-46482d6107f7b115", "contract": {"claim_id": "ad_aging_q018", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "pet_fdg_suvr", "predictor": "beh_cdrsb", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx in [\"CN\", \"MCI\", \"Dementia\"]", "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is increasing clinical impairment from CN to MCI to Dementia associated with progressively lower pet_fdg_suvr, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c2b02d58d24ba60daf2b0fab1860326813cfd95d682e7e00098e44931d13b8a2", "migration_status": "ambiguous_unresolved", "modality": "PET", "pre_v2_contract_sha256": "c2b02d58d24ba60daf2b0fab1860326813cfd95d682e7e00098e44931d13b8a2", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q018", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is increasing clinical impairment from CN to MCI to Dementia associated with progressively lower pet_fdg_suvr, adjusting for age and sex?", "question_sha256": "c6fc271e53fb2d68fd2b594f1ca2451ed500ac56580dfd87511ad028dd86246b", "reference_id": "ncb-scientific-c2b02d58d24ba60d", "scientific_core_sha256": "6942871f45fb044cbe81a6633afa1dfb0a6a05fe3e73cbe2576817576e8ad9da", "semantic_cluster_id": "ncb-sem-46482d6107f7b115", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["pubmed_35388950_pmid35388950_ad_havas_detection"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-c3a081875a1cf586", "benchmark_track": "scientific", "claim_uid": "ncb-claim-6c7a1e7db4b6dcd5", "contract": {"claim_id": "pubmed_35388950_pmid35388950_ad_havas_detection", "covariates": ["age", "eTIV", "sex"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_ventricles", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "eTIV", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded Higher HAVAs / Alzheimer disease versus control status effect on Alzheimer disease detection / diagnostic classification in sMRI volumetric MRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction positive and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c3a081875a1cf586a007ce8ca93186b5680d0217ed8d6cb1ee78167cf39f91bb", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "c3a081875a1cf586a007ce8ca93186b5680d0217ed8d6cb1ee78167cf39f91bb", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:35388950; DOI:10.1002/hbm.25850", "source_collection": "stage2_current", "source_id": "pubmed_35388950_pmid35388950_ad_havas_detection", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "For literature-grounded Higher HAVAs / Alzheimer disease versus control status effect on Alzheimer disease detection / diagnostic classification in sMRI volumetric MRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction positive and adjust for age;eTIV;sex when available.", "question_sha256": "f53f8e95dae61c20b6955e509af8491a6986c33474734d95c5ddad01b32666c6", "reference_id": "ncb-scientific-c3a081875a1cf586", "scientific_core_sha256": "536c28b3f83e9d521d3da2f902f7291bd66d3a5761f155fc269b3c36996e62fb", "semantic_cluster_id": "ncb-sem-6c7a1e7db4b6dcd5", "target_family": "ad_aging", "task_ids": ["ncb21-task-61b1b74fe9df4b4f"]}
{"aliases": ["asd_q038"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-c631e745a39a4c34", "benchmark_track": "scientific", "claim_uid": "ncb-claim-36d900948ef5a6c9", "contract": {"claim_id": "asd_q038", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Vis_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Vis_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c631e745a39a4c34b7a2b47ee20ac723363fb4d3f247ba63938ada9c0511f640", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "c631e745a39a4c34b7a2b47ee20ac723363fb4d3f247ba63938ada9c0511f640", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q038", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Vis_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "fafd5037b8601c23c53be1427181a301e0c7cb55c0ce7ed82f6c3f9c922fedde", "reference_id": "ncb-scientific-c631e745a39a4c34", "scientific_core_sha256": "d58de6cb3567b771970ef7e1781d5993de3bfdc0c51b47480687006ae9781bf5", "semantic_cluster_id": "ncb-sem-36d900948ef5a6c9", "target_family": "asd", "task_ids": ["ncb21-task-2378bd6a4aa6d917"]}
{"aliases": ["adhd_q031"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-c64dac21d8591104", "benchmark_track": "scientific", "claim_uid": "ncb-claim-4297ac55ed4096d3", "contract": {"claim_id": "adhd_q031", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, do ADHD cases (dx=1.0) differ from controls (dx=0.0) in Limbic-Visual connectivity (fc_fc_Limbic_Vis_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c64dac21d8591104aa2912c0fc623cb3df7ae2fad45f89683dcc7f18692dc403", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "c64dac21d8591104aa2912c0fc623cb3df7ae2fad45f89683dcc7f18692dc403", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q031", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, do ADHD cases (dx=1.0) differ from controls (dx=0.0) in Limbic-Visual connectivity (fc_fc_Limbic_Vis_z), with no additional covariates?", "question_sha256": "4037e2e75b04cd9206d8c402d57a297ff5c80638d0578700e00a403422e06da0", "reference_id": "ncb-scientific-c64dac21d8591104", "scientific_core_sha256": "c324ba257320a23e560e6c562bf89909368d9cd09f43cd48515fe66601be4753", "semantic_cluster_id": "ncb-sem-4297ac55ed4096d3", "target_family": "adhd", "task_ids": ["ncb21-task-a32df69d3ffcf15e"]}
{"aliases": ["pubmed_29653095_29653095-psychosis-fc-01"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-c671d3de1b2734cb", "benchmark_track": "scientific", "claim_uid": "ncb-claim-71354e62dc1c127c", "contract": {"claim_id": "pubmed_29653095_29653095-psychosis-fc-01", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": "large_scale_resting_state_network_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded Psychosis probands versus healthy controls effect on large-scale resting-state network connectivity in fMRI-FC, using BSNIP2 as discovery and COBRE as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c671d3de1b2734cb8e64ccc55fdd15ea4118e551d604845c6f756f7b71f7ba43", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "c671d3de1b2734cb8e64ccc55fdd15ea4118e551d604845c6f756f7b71f7ba43", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:29653095; DOI:10.1016/j.bpsc.2016.07.001", "source_collection": "stage2_current", "source_id": "pubmed_29653095_29653095-psychosis-fc-01", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "For literature-grounded Psychosis probands versus healthy controls effect on large-scale resting-state network connectivity in fMRI-FC, using BSNIP2 as discovery and COBRE as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "question_sha256": "54acffd20c41e9a0c533f35de4add5b79743714fedc400c8ca10b2f70357ed1f", "reference_id": "ncb-scientific-c671d3de1b2734cb", "scientific_core_sha256": "43b855c64b7c2cc5f63a22df184254771d788f101b301cfd61e9e920bdaa187a", "semantic_cluster_id": "ncb-sem-71354e62dc1c127c", "target_family": "psychosis", "task_ids": ["ncb21-task-2af7eda20deedfc3"]}
{"aliases": ["asd_q041"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-c823298f5f12df8a", "benchmark_track": "scientific", "claim_uid": "ncb-claim-7b2670c1d81fe2d1", "contract": {"claim_id": "asd_q041", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_DorsAttn_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c823298f5f12df8af07efc39e57413ee6b375c5f9f95bf060e712101c70c15cd", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "c823298f5f12df8af07efc39e57413ee6b375c5f9f95bf060e712101c70c15cd", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q041", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_DorsAttn_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "82b424dd24392485dfe0585b2ac8274ad9969c38a52bb25afb4c2cb29a0b96dc", "reference_id": "ncb-scientific-c823298f5f12df8a", "scientific_core_sha256": "ee197ababc2ae9042952f1fd8de0b47a4193ab15f3f80c00617bbda61704bbe2", "semantic_cluster_id": "ncb-sem-7b2670c1d81fe2d1", "target_family": "asd", "task_ids": ["ncb21-task-f881acc3dcf78298"]}
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{"aliases": ["pubmed_31265198_pmid31265198_fc_adhd_vs_tdc"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-c8acae9508ef35fd", "benchmark_track": "scientific", "claim_uid": "ncb-claim-1671056a239d54c1", "contract": {"claim_id": "pubmed_31265198_pmid31265198_fc_adhd_vs_tdc", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "resting_state_functional_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 190, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded ADHD patients versus typically developing controls effect on seed-based functional connectivity in resting-state fMRI functional connectivity, using ABCD as discovery and ADHD200 as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 190, "selection": "preregistered"}}, "contract_sha256": "c8acae9508ef35fd71e17be422a96ff94cda16d53561647f67cc34bf3fb5e2dc", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "c8acae9508ef35fd71e17be422a96ff94cda16d53561647f67cc34bf3fb5e2dc", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:31265198; DOI:10.1002/jmri.26854", "source_collection": "stage2_current", "source_id": "pubmed_31265198_pmid31265198_fc_adhd_vs_tdc", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "For literature-grounded ADHD patients versus typically developing controls effect on seed-based functional connectivity in resting-state fMRI functional connectivity, using ABCD as discovery and ADHD200 as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "question_sha256": "496881fa0a06016a7fe25e29742550dbf996ec2b05312029a2998e312a09c937", "reference_id": "ncb-scientific-c8acae9508ef35fd", "scientific_core_sha256": "7168dd728c1670843341d19e4c97ff0a5c3eca44d33cc9bd4528b2bfdf4a1bf1", "semantic_cluster_id": "ncb-sem-1671056a239d54c1", "target_family": "adhd", "task_ids": ["ncb21-task-f9773dc8fdf57d18"]}
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{"aliases": ["pubmed_37121277_pmid37121277_mccfc_cluster2_vs_td"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-c98428886dd0f1d9", "benchmark_track": "scientific", "claim_uid": "ncb-claim-5764b4fe5f95de4a", "contract": {"claim_id": "pubmed_37121277_pmid37121277_mccfc_cluster2_vs_td", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded ASD Cluster-2 with moderate ADI-R impairment versus typical-development controls effect on MCC-related whole-brain functional connectivity in resting-state fMRI functional connectivity, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c98428886dd0f1d91c3a75d885826b5fb7726225297f515afa05718599e2996d", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "c98428886dd0f1d91c3a75d885826b5fb7726225297f515afa05718599e2996d", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:37121277; DOI:10.1016/j.bbr.2023.114458", "source_collection": "stage2_current", "source_id": "pubmed_37121277_pmid37121277_mccfc_cluster2_vs_td", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "For literature-grounded ASD Cluster-2 with moderate ADI-R impairment versus typical-development controls effect on MCC-related whole-brain functional connectivity in resting-state fMRI functional connectivity, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "question_sha256": "44ac741d0130ee73f4fdddb8442c09172384b07c0f76a5ad941db570dedd7511", "reference_id": "ncb-scientific-c98428886dd0f1d9", "scientific_core_sha256": "7479f5b2f60e18191ed5f30360e3fe7c2f540dce44899019cd404899ee0a94db", "semantic_cluster_id": "ncb-sem-5764b4fe5f95de4a", "target_family": "asd", "task_ids": []}
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{"aliases": ["normative_fmri_026"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-cb339bf30281cede", "benchmark_track": "scientific", "claim_uid": "ncb-claim-54412458ba1b1520", "contract": {"claim_id": "normative_fmri_026", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_SomMot_SomMot_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, is higher age associated with lower somatomotor within-network connectivity (fc_fc_SomMot_SomMot_z), adjusting for sex and cognition?", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cb339bf30281cedea3769b3c8ba3c0199ad8889c6569c72e5720af2c4c1b226d", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "cb339bf30281cedea3769b3c8ba3c0199ad8889c6569c72e5720af2c4c1b226d", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_026", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, is higher age associated with lower somatomotor within-network connectivity (fc_fc_SomMot_SomMot_z), adjusting for sex and cognition?", "question_sha256": "0aa2228a096b0e664538eeb85ad592e24e1e86c968e157af074ef47570ee4519", "reference_id": "ncb-scientific-cb339bf30281cede", "scientific_core_sha256": "a301c2c36e13898584f2156b1a29e59116fbbeaa86958bf463ba6a44cf7d0288", "semantic_cluster_id": "ncb-sem-54412458ba1b1520", "target_family": "normative_fmri", "task_ids": ["ncb21-task-3d920ec7800c2bfa"]}
{"aliases": ["pubmed_28040544_pmid28040544_asd_fc_kea_corticalnetworks"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-cb86d4103ebb0e0c", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2bf57780df2813c6", "contract": {"claim_id": "pubmed_28040544_pmid28040544_asd_fc_kea_corticalnetworks", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "KEA_cortical_networks_orbitofrontal_anterior_cingulate_middle_temporal_precuneus", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.2, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded Autism diagnosis versus control status effect on Resting-state functional connectivity in KEA-defined cortical networks involving orbitofrontal cortex, anterior cingulate cortex, middle temporal gyrus, and precuneus in fMRI-FC, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "cb86d4103ebb0e0cfb84aeae03b006b1b9f5e196a73b165f42e271c167d1f8d0", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "cb86d4103ebb0e0cfb84aeae03b006b1b9f5e196a73b165f42e271c167d1f8d0", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:28040544; DOI:10.1016/j.neuroimage.2016.12.068", "source_collection": "stage2_current", "source_id": "pubmed_28040544_pmid28040544_asd_fc_kea_corticalnetworks", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "For literature-grounded Autism diagnosis versus control status effect on Resting-state functional connectivity in KEA-defined cortical networks involving orbitofrontal cortex, anterior cingulate cortex, middle temporal gyrus, and precuneus in fMRI-FC, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "question_sha256": "9ec192bbb8f21607d8ba21254c8afeec6cc3faedf3e55a441a97d3fcbcf5d56c", "reference_id": "ncb-scientific-cb86d4103ebb0e0c", "scientific_core_sha256": "2eb4eeb12f6080c6e3aeb98bd813f454f2d1004f546c9b164dfeadf3a4ca35c6", "semantic_cluster_id": "ncb-sem-2bf57780df2813c6", "target_family": "asd", "task_ids": ["ncb21-task-d3daf7fbc0850859"]}
{"aliases": ["ad_aging_q036"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-cc1c11b70cdbc35f", "benchmark_track": "scientific", "claim_uid": "ncb-claim-4cf6bd4d0048276f", "contract": {"claim_id": "ad_aging_q036", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "pet_av45", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In ADNI_DISC, among CN participants, is older age associated with higher pet_av45, adjusting for sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cc1c11b70cdbc35f0fb7b7692822abca760f09315d96cba5c2e0c0d8c07fcfe3", "migration_status": "ready", "modality": "PET", "pre_v2_contract_sha256": "cc1c11b70cdbc35f0fb7b7692822abca760f09315d96cba5c2e0c0d8c07fcfe3", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q036", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, among CN participants, is older age associated with higher pet_av45, adjusting for sex?", "question_sha256": "17ef9671c214ecfe60e3d1d6f4a056a94c24992d89c2b4b35ee417f8bfc4cfc2", "reference_id": "ncb-scientific-cc1c11b70cdbc35f", "scientific_core_sha256": "33630bae3c1c57446d8568d4a1d6be8caffddf55aa18b716e424c71fe7c68e23", "semantic_cluster_id": "ncb-sem-4cf6bd4d0048276f", "target_family": "ad_aging", "task_ids": ["ncb21-task-a389468db376c4f4"]}
{"aliases": ["ad_aging_q025"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-cc2914e36309cad4", "benchmark_track": "scientific", "claim_uid": "ncb-claim-5ec25f86a95995a3", "contract": {"claim_id": "ad_aging_q025", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_midtemp", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with lower smri_midtemp than CN, adjusting for age and sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cc2914e36309cad42e9bff4b0a6351fa56b156cb121cb9074b25063a25f3fff5", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "cc2914e36309cad42e9bff4b0a6351fa56b156cb121cb9074b25063a25f3fff5", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q025", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with lower smri_midtemp than CN, adjusting for age and sex?", "question_sha256": "d325e8268a83c8fa1541ef6341c812f8d9c73d2eac79f89951e182a9591e7688", "reference_id": "ncb-scientific-cc2914e36309cad4", "scientific_core_sha256": "3ad59694b84444ecb7f263e017fbe73bd62dd8beaaa1603c826756e4ba546c5b", "semantic_cluster_id": "ncb-sem-5ec25f86a95995a3", "target_family": "ad_aging", "task_ids": ["ncb21-task-0a1ed327c94ac9a5"]}
{"aliases": ["adhd_q007"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-ccf76ee04722df94", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a78bc3d5c2482eab", "contract": {"claim_id": "adhd_q007", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC, excluding missing dx, do ADHD cases (dx=1.0) differ from controls (dx=0.0) in within-DorsalAttention connectivity (fc_fc_DorsAttn_DorsAttn_z), with no additional covariates, and is the difference replicated in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ccf76ee04722df945c7c574a27b2da49fc63bef96e9b9b9f3ee1612f4beb0257", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "ccf76ee04722df945c7c574a27b2da49fc63bef96e9b9b9f3ee1612f4beb0257", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q007", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC, excluding missing dx, do ADHD cases (dx=1.0) differ from controls (dx=0.0) in within-DorsalAttention connectivity (fc_fc_DorsAttn_DorsAttn_z), with no additional covariates, and is the difference replicated in ABCD_REP?", "question_sha256": "d87f3407ef1037002f2040f38a585d777582f88c865231dae7f9968130e7640e", "reference_id": "ncb-scientific-ccf76ee04722df94", "scientific_core_sha256": "1d9d47d8fb3306553ad618d72cc1edd153c18a615ede16497517080992ffebab", "semantic_cluster_id": "ncb-sem-a78bc3d5c2482eab", "target_family": "adhd", "task_ids": ["ncb21-task-217080e5d5d61690"]}
{"aliases": ["ad_aging_q012"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-ce5c0063d478e61d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-f3e4911f433998d2", "contract": {"claim_id": "ad_aging_q012", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_hippocampus", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In ADNI_DISC, among CN participants, is older age associated with lower smri_hippocampus, adjusting for sex?", "replication_cohorts": ["ADNI_REP", "OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ce5c0063d478e61da293889593af2afd1b8b29c77b2df5c7d7de1191d162c10c", "migration_status": "ready", "modality": "sMRI", "pre_v2_contract_sha256": "ce5c0063d478e61da293889593af2afd1b8b29c77b2df5c7d7de1191d162c10c", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q012", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, among CN participants, is older age associated with lower smri_hippocampus, adjusting for sex?", "question_sha256": "3da394c3a30e23294013cccfc65037f96a4f2d8eed9a06c86cb73d751dff11e4", "reference_id": "ncb-scientific-ce5c0063d478e61d", "scientific_core_sha256": "7d494c68bdd53df5e8e4d1696c6cb9570310dcc82fe9e3a9d5833d7ab948fbe5", "semantic_cluster_id": "ncb-sem-f3e4911f433998d2", "target_family": "ad_aging", "task_ids": ["ncb21-task-b0061b835ca1457f"]}
{"aliases": ["pubmed_36403658_pmid36403658_adhd_fc_classifier"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-ce9b34e85b1510c7", "benchmark_track": "scientific", "claim_uid": "ncb-claim-9a49e748df2ba005", "contract": {"claim_id": "pubmed_36403658_pmid36403658_adhd_fc_classifier", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "resting_state_functional_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 190, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded healthy controls, social phobia without ADHD, and social phobia with ADHD comorbidity effect on multivariate classification using functional connectivity strength and topology features in resting-state fMRI functional connectivity, using ABCD as discovery and ADHD200 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 190, "selection": "preregistered"}}, "contract_sha256": "ce9b34e85b1510c7cdb61caab47224a564c4d18a9d89c72c6952a58e8ed87491", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "ce9b34e85b1510c7cdb61caab47224a564c4d18a9d89c72c6952a58e8ed87491", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:36403658; DOI:10.1016/j.neuropsychologia.2022.108418", "source_collection": "stage2_current", "source_id": "pubmed_36403658_pmid36403658_adhd_fc_classifier", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "For literature-grounded healthy controls, social phobia without ADHD, and social phobia with ADHD comorbidity effect on multivariate classification using functional connectivity strength and topology features in resting-state fMRI functional connectivity, using ABCD as discovery and ADHD200 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "question_sha256": "7421175b2096c21c0b5e64a0e0aa9d6b008eae9399f641013be99353c44e7791", "reference_id": "ncb-scientific-ce9b34e85b1510c7", "scientific_core_sha256": "66697fc6f37b179f47e10d1343b50e3b136fcac39589669f21cad41afa9191c8", "semantic_cluster_id": "ncb-sem-9a49e748df2ba005", "target_family": "adhd", "task_ids": []}
{"aliases": ["asd_q040"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-cfe09363aec199e4", "benchmark_track": "scientific", "claim_uid": "ncb-claim-a7e5d3c11d8415e9", "contract": {"claim_id": "asd_q040", "covariates": [], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Default_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cfe09363aec199e4d87cfd179508934aa0a694e2ac85f122d79bab05a56bf5ba", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "cfe09363aec199e4d87cfd179508934aa0a694e2ac85f122d79bab05a56bf5ba", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q040", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Default_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "6a4dc9064b09c7072d2ebd1f18d158dd9de28db5c64f9b5312460d490e6899b0", "reference_id": "ncb-scientific-cfe09363aec199e4", "scientific_core_sha256": "fe02b61f8be7f79c488b5f3c770fa296ca58555ba70789fce60ae7b50516eb18", "semantic_cluster_id": "ncb-sem-a7e5d3c11d8415e9", "target_family": "asd", "task_ids": ["ncb21-task-e1c38e33b7e80abc"]}
{"aliases": ["adhd_q017"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-cff1d7d2ccfb4083", "benchmark_track": "scientific", "claim_uid": "ncb-claim-431a40f2cc1f5ed6", "contract": {"claim_id": "adhd_q017", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Salience/VentralAttention-Somatomotor connectivity (fc_fc_SalVentAttn_SomMot_z), with no additional covariates, and does this replicate in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cff1d7d2ccfb4083777868ad19918ae7945541ba0eac4f51f5d045cb634efc6b", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "cff1d7d2ccfb4083777868ad19918ae7945541ba0eac4f51f5d045cb634efc6b", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q017", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Salience/VentralAttention-Somatomotor connectivity (fc_fc_SalVentAttn_SomMot_z), with no additional covariates, and does this replicate in ADHD200_REP?", "question_sha256": "709e9febbf7abd25df4363a4d1182f95a9e3a8fa6210b3dcb398f946fc7bbe9f", "reference_id": "ncb-scientific-cff1d7d2ccfb4083", "scientific_core_sha256": "5df824301ab1addd97daaf4023192f0090f63d68208b8c74686e168f40a67e43", "semantic_cluster_id": "ncb-sem-431a40f2cc1f5ed6", "target_family": "adhd", "task_ids": ["ncb21-task-1ee6ff3275d5a6b2"]}
{"aliases": ["psychosis_q039"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-d0535a6cab6d913b", "benchmark_track": "scientific", "claim_uid": "ncb-claim-6c35024a79091cc0", "contract": {"claim_id": "psychosis_q039", "covariates": [], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across COBRE_DISC and COBRE_REP, is the SZ-versus-HC contrast for fc_within_network directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d0535a6cab6d913b7aae20a3c6e47c1d8b5c21a56abd87a6f45877adf81829e0", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "d0535a6cab6d913b7aae20a3c6e47c1d8b5c21a56abd87a6f45877adf81829e0", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q039", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "Across COBRE_DISC and COBRE_REP, is the SZ-versus-HC contrast for fc_within_network directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "question_sha256": "2865cc357ad9e78529f2933b956eeee50c62f939ff14b00077259b8823f0a7a9", "reference_id": "ncb-scientific-d0535a6cab6d913b", "scientific_core_sha256": "edd521086383f67cc2d26e964127ebbf406e84c4db92d7bde5aa6226cc4c28a6", "semantic_cluster_id": "ncb-sem-6c35024a79091cc0", "target_family": "psychosis", "task_ids": ["ncb21-task-dc81572c10516fb6"]}
{"aliases": ["normative_fmri_024"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-d0e3c2468afe4539", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2b84eedb776ad4bf", "contract": {"claim_id": "normative_fmri_024", "covariates": ["sex", "site", "phen_fluid_composite"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "site", "phen_fluid_composite"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, is higher age associated with higher default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for sex and cognition?", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d0e3c2468afe45395a1d6887f96a757cb6cedbc19164247267f228b20c1f9067", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "d0e3c2468afe45395a1d6887f96a757cb6cedbc19164247267f228b20c1f9067", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_024", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, is higher age associated with higher default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for sex and cognition?", "question_sha256": "ed9953899bc988a5e5009042c2578b4eece7c13e0340b2a414f84cb894ed3fb0", "reference_id": "ncb-scientific-d0e3c2468afe4539", "scientific_core_sha256": "952d57058977fdd6613ea34b2dd45e721b3318e5eca7c0cd360552cc3ac9f42c", "semantic_cluster_id": "ncb-sem-2b84eedb776ad4bf", "target_family": "normative_fmri", "task_ids": ["ncb21-task-d2e03b9aa3b48e11"]}
{"aliases": ["adhd_q030"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-d37402dd791a12dc", "benchmark_track": "scientific", "claim_uid": "ncb-claim-b2165137d6f2cd98", "contract": {"claim_id": "adhd_q030", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 1.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered DorsalAttention-Salience/VentralAttention connectivity (fc_fc_DorsAttn_SalVentAttn_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d37402dd791a12dc5975c0b5a9fc0994be3d63826bdbf317c431e337efa54f61", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "d37402dd791a12dc5975c0b5a9fc0994be3d63826bdbf317c431e337efa54f61", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q030", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered DorsalAttention-Salience/VentralAttention connectivity (fc_fc_DorsAttn_SalVentAttn_z), with no additional covariates?", "question_sha256": "292a25ddcfeea37f416e546f540c64b17449babb3a50f8339797531ea860787d", "reference_id": "ncb-scientific-d37402dd791a12dc", "scientific_core_sha256": "d003381a01bb233a9475b078649877a01efae6bfdb87a9fd8387c75a2a4c0fc4", "semantic_cluster_id": "ncb-sem-b2165137d6f2cd98", "target_family": "adhd", "task_ids": ["ncb21-task-9e1aef9a7ecc24a2"]}
{"aliases": ["asd_q019"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-d3b9d78a966173c6", "benchmark_track": "scientific", "claim_uid": "ncb-claim-ad2e72eb3441438a", "contract": {"claim_id": "asd_q019", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_DorsAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_DorsAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d3b9d78a966173c6a58a5b8ed01a0316ad73601092701d1310f08cee0928e62e", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "d3b9d78a966173c6a58a5b8ed01a0316ad73601092701d1310f08cee0928e62e", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "asd_q019", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "asd"}], "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_DorsAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "question_sha256": "41065d358cb9078ccbb06422c2694f7cfad4dfbcfda49f6ca8be7b03e1235ffc", "reference_id": "ncb-scientific-d3b9d78a966173c6", "scientific_core_sha256": "cdc0a3e3583d3137226e1f9d0fb6a7262fea7ce6e2b83140279b21a1c58830af", "semantic_cluster_id": "ncb-sem-ad2e72eb3441438a", "target_family": "asd", "task_ids": ["ncb21-task-0aedc228888c5eae"]}
{"aliases": ["psychosis_q011"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-d4c0b42a60357a5d", "benchmark_track": "scientific", "claim_uid": "ncb-claim-2166e66544e56e96", "contract": {"claim_id": "psychosis_q011", "covariates": ["age", "sex", "site"], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_DISC, is fc_within_network lower in SZ than HC in an unadjusted group comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d4c0b42a60357a5d939e12105a02798899968bed182f8471def699471bf39842", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "d4c0b42a60357a5d939e12105a02798899968bed182f8471def699471bf39842", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q011", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In COBRE_DISC, is fc_within_network lower in SZ than HC in an unadjusted group comparison with dx as the only predictor and no covariates?", "question_sha256": "268874f0caddc32a56475d579d3e315fac40387f7bec01ff2964398e0b3bf634", "reference_id": "ncb-scientific-d4c0b42a60357a5d", "scientific_core_sha256": "edd521086383f67cc2d26e964127ebbf406e84c4db92d7bde5aa6226cc4c28a6", "semantic_cluster_id": "ncb-sem-2166e66544e56e96", "target_family": "psychosis", "task_ids": ["ncb21-task-08c01f90e76c8f85"]}
{"aliases": ["normative_fmri_036"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-d6cbeb536d2b0163", "benchmark_track": "scientific", "claim_uid": "ncb-claim-ce4cface1e4e8236", "contract": {"claim_id": "normative_fmri_036", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher cognition associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and sex?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d6cbeb536d2b01632b3c753bd865bcb7f96749ca7f83705faf307f82a8ceda07", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "d6cbeb536d2b01632b3c753bd865bcb7f96749ca7f83705faf307f82a8ceda07", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_036", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher cognition associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and sex?", "question_sha256": "91db835974b0b3a4116f0ca5bfba75df642f5cb9e2df009aa224269244928cdc", "reference_id": "ncb-scientific-d6cbeb536d2b0163", "scientific_core_sha256": "9e63074cf36234974e50a155d2a5a353103ad45fcf26453f76da5fd49fd71f89", "semantic_cluster_id": "ncb-sem-ce4cface1e4e8236", "target_family": "normative_fmri", "task_ids": ["ncb21-task-a2cefcd7709126f7"]}
{"aliases": ["sex_smri_hippocampus_gsp_adni_cn"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-da6e0b38e7772e80", "benchmark_track": "scientific", "claim_uid": "ncb-claim-494b154ddee82225", "contract": {"claim_id": "sex_smri_hippocampus_gsp_adni_cn", "covariates": ["age", "eTIV", "site"], "discovery_cohort": "GSP_DISC", "estimand": {"direction": "negative", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "smri_hippocampus", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 3, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx in [\"HC\", \"CN\"]", "question": "For sex difference in eTIV-adjusted hippocampal volume in sMRI, using GSP as discovery and ADNI_CN as replication, test the claim with expected direction female_minus_male negative on hippocampal volume after age and eTIV adjustment and adjust for age;eTIV when available.", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "da6e0b38e7772e80aea1f58d4a4006eca8cf9c7e3bc872b5d952c3853da64503", "migration_status": "ambiguous_unresolved", "modality": "sMRI", "pre_v2_contract_sha256": "da6e0b38e7772e80aea1f58d4a4006eca8cf9c7e3bc872b5d952c3853da64503", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "Ritchie et al. 2018 Cerebral Cortex", "source_collection": "legacy_scientific", "source_id": "sex_smri_hippocampus_gsp_adni_cn", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "normative_fmri"}], "question": "For sex difference in eTIV-adjusted hippocampal volume in sMRI, using GSP as discovery and ADNI_CN as replication, test the claim with expected direction female_minus_male negative on hippocampal volume after age and eTIV adjustment and adjust for age;eTIV when available.", "question_sha256": "de8e6e2d8702bb8a61de5ef970eb0a5e5d44b927e87b4e0cb09e7dfe01c3addf", "reference_id": "ncb-scientific-da6e0b38e7772e80", "scientific_core_sha256": "380b875a6be20514906b9c85d046ada773bca97e0e441308690e6b146dc21455", "semantic_cluster_id": "ncb-sem-494b154ddee82225", "target_family": "normative_fmri", "task_ids": []}
{"aliases": ["ad_aging_q013", "ad_aging_q015", "ad_aging_q019"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-da99887ee1c161f8", "benchmark_track": "scientific", "claim_uid": "ncb-claim-d22048e0b525ef58", "contract": {"claim_id": "ad_aging_q013", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "pet_av45", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with higher pet_av45 than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "da99887ee1c161f8ace824a8f4f353abd0b75b76e0f9cc87e3fdc1d6e2cca576", "migration_status": "ready", "modality": "PET", "pre_v2_contract_sha256": "da99887ee1c161f8ace824a8f4f353abd0b75b76e0f9cc87e3fdc1d6e2cca576", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q013", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}, {"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q015", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}, {"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "ad_aging_q019", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with higher pet_av45 than CN, adjusting for age and sex?", "question_sha256": "971e0ba85bd308439b4473e5b129c205065eb077bfa7cab7d9489fdd1bf8314e", "reference_id": "ncb-scientific-da99887ee1c161f8", "scientific_core_sha256": "94b82c5a937c61645989e76a195386477c181f2c9fbd0b2ffa19373518d83fa7", "semantic_cluster_id": "ncb-sem-d22048e0b525ef58", "target_family": "ad_aging", "task_ids": ["ncb21-task-b148816c3f2385a3"]}
{"aliases": ["adhd_region_adhd200_abcd"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-dc2d5ad4964bca96", "benchmark_track": "scientific", "claim_uid": "ncb-claim-496f6200eab60252", "contract": {"claim_id": "adhd_region_adhd200_abcd", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "raw_fmri_region_", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 76, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ADHD case-control fMRI regional difference in fMRI-region, using ADHD200 as discovery and ABCD as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 76, "selection": "preregistered"}}, "contract_sha256": "dc2d5ad4964bca964b15ebb2637b5eba244814c6906a20b19cd600878ccb4570", "migration_status": "ready", "modality": "other", "pre_v2_contract_sha256": "dc2d5ad4964bca964b15ebb2637b5eba244814c6906a20b19cd600878ccb4570", "provenance": [{"prior_label": "fragile", "source_citation": "ADHD-200 Consortium 2012", "source_collection": "legacy_scientific", "source_id": "adhd_region_adhd200_abcd", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "adhd"}], "question": "For ADHD case-control fMRI regional difference in fMRI-region, using ADHD200 as discovery and ABCD as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "question_sha256": "dec4f932dce09d7f95e9a3046349bbb5c55fa66e864f0c7511751744056b91ee", "reference_id": "ncb-scientific-dc2d5ad4964bca96", "scientific_core_sha256": "b1a4f6639fe27d228938bad44ad8f448065650677f948f3c70dce5dd7206482f", "semantic_cluster_id": "ncb-sem-496f6200eab60252", "target_family": "adhd", "task_ids": ["ncb21-task-d568db2d613cee3b"]}
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{"aliases": ["psychosis_q007"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-e5b2412738b16335", "benchmark_track": "scientific", "claim_uid": "ncb-claim-6c35024a79091cc0", "contract": {"claim_id": "psychosis_q007", "covariates": [], "discovery_cohort": "BSNIP2_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_REP, is fc_within_network lower in SZ than HC in an unadjusted dx-only group comparison with no covariates?", "replication_cohorts": ["ChineseSZ_REP", "FBIRN_REP", "COBRE_REP", "Olin_SZ_REP", "JH_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e5b2412738b16335f55b1518f3aac394c8cfff48e1b39a9dc0d2b64c2cbb5877", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "e5b2412738b16335f55b1518f3aac394c8cfff48e1b39a9dc0d2b64c2cbb5877", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "psychosis_q007", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "psychosis"}], "question": "In BSNIP2_REP, is fc_within_network lower in SZ than HC in an unadjusted dx-only group comparison with no covariates?", "question_sha256": "6be75917f0e2f16e42737a15e1d03b83801e2cfd0f7880fd0c744de4b4194bea", "reference_id": "ncb-scientific-e5b2412738b16335", "scientific_core_sha256": "56c782efac5ece982421f6cc450e0a71823dbb420d4309f34cf0bab1b9426b92", "semantic_cluster_id": "ncb-sem-6c35024a79091cc0", "target_family": "psychosis", "task_ids": ["ncb21-task-90944d2b4886bb16"]}
{"aliases": ["pubmed_34649002_pmid34649002_brainage_attnwm"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-e5be6d84f8e872b5", "benchmark_track": "scientific", "claim_uid": "ncb-claim-34e75ab9f2a20a94", "contract": {"claim_id": "pubmed_34649002_pmid34649002_brainage_attnwm", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "smri_ventricles", "predictor": "beh_cdrsb", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded Advanced brain age / higher atrophy-based brain age estimate effect on domain-specific cognitive impairment: attention and working memory in structural MRI-derived brain age estimate with neuropsychological test outcomes, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction positive and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e5be6d84f8e872b5e5382923d529f5e638a49c79635afdd5fd90ca94bee033c0", "migration_status": "ambiguous_unresolved", "modality": "sMRI", "pre_v2_contract_sha256": "e5be6d84f8e872b5e5382923d529f5e638a49c79635afdd5fd90ca94bee033c0", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "PMID:34649002; DOI:10.1016/j.neurobiolaging.2021.08.020", "source_collection": "stage2_current", "source_id": "pubmed_34649002_pmid34649002_brainage_attnwm", "source_mode": "literature_grounded", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "ad_aging"}], "question": "For literature-grounded Advanced brain age / higher atrophy-based brain age estimate effect on domain-specific cognitive impairment: attention and working memory in structural MRI-derived brain age estimate with neuropsychological test outcomes, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction positive and adjust for age;eTIV;sex when available.", "question_sha256": "b9a5084e40ed136453fa78c607c671d831a7a96ce87ec65562822389ffcb59b6", "reference_id": "ncb-scientific-e5be6d84f8e872b5", "scientific_core_sha256": "cc157d8a039957a9d7571c621a576b2d41a942573356bb18b8eee9e856ba5638", "semantic_cluster_id": "ncb-sem-34e75ab9f2a20a94", "target_family": "ad_aging", "task_ids": []}
{"aliases": ["adhd_q038"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-e61ccc72bef4061c", "benchmark_track": "scientific", "claim_uid": "ncb-claim-b32f9eea34f48563", "contract": {"claim_id": "adhd_q038", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered DorsalAttention-Salience/VentralAttention connectivity (fc_fc_DorsAttn_SalVentAttn_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e61ccc72bef4061ce3d466c68b9f2898acb4cf373aa0cdf600d200efef581b25", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "e61ccc72bef4061ce3d466c68b9f2898acb4cf373aa0cdf600d200efef581b25", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q038", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered DorsalAttention-Salience/VentralAttention connectivity (fc_fc_DorsAttn_SalVentAttn_z), with no additional covariates?", "question_sha256": "72f823cd6727d3ca2473646d2fb99d420fad17685fc7a0dd7051f9255cb79731", "reference_id": "ncb-scientific-e61ccc72bef4061c", "scientific_core_sha256": "bcbc62719dc9cf8604e9902e4891a802b961a32646ed29162c019a1eb6c975d4", "semantic_cluster_id": "ncb-sem-b32f9eea34f48563", "target_family": "adhd", "task_ids": ["ncb21-task-8f7b785586ca8640"]}
{"aliases": ["adhd_q002"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-e655e7f3059cc2a2", "benchmark_track": "scientific", "claim_uid": "ncb-claim-b9ed4cced1a322ad", "contract": {"claim_id": "adhd_q002", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with higher Default-Salience/VentralAttention connectivity (fc_fc_Default_SalVentAttn_z), with no additional covariates, and is this replicated in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e655e7f3059cc2a2fa0bfd47f5738215071ffd1c322d56face875667b06330b8", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "e655e7f3059cc2a2fa0bfd47f5738215071ffd1c322d56face875667b06330b8", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q002", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with higher Default-Salience/VentralAttention connectivity (fc_fc_Default_SalVentAttn_z), with no additional covariates, and is this replicated in ABCD_REP?", "question_sha256": "ca9d65dbe55f436643649c8b8bcfd65890cffe115c655917bc60e7333a44fd48", "reference_id": "ncb-scientific-e655e7f3059cc2a2", "scientific_core_sha256": "158fa35591c0432d6f39d69fb2b847f7bbbbebe5dfc9c30f7b1e3824d1070c28", "semantic_cluster_id": "ncb-sem-b9ed4cced1a322ad", "target_family": "adhd", "task_ids": ["ncb21-task-20579a56de42c261"]}
{"aliases": ["normative_fmri_009"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-e7c94f56c83e0651", "benchmark_track": "scientific", "claim_uid": "ncb-claim-1ccf84c3360dce0e", "contract": {"claim_id": "normative_fmri_009", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Cont_DorsAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower connectivity between control and dorsal-attention networks (fc_fc_Cont_DorsAttn_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e7c94f56c83e06518cfb23793f51ccaf963a39435caaaca93bcd7d7166f65091", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "e7c94f56c83e06518cfb23793f51ccaf963a39435caaaca93bcd7d7166f65091", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_009", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower connectivity between control and dorsal-attention networks (fc_fc_Cont_DorsAttn_z), adjusting for sex and cognition?", "question_sha256": "9548f0e29007f9d3fc6fa0976189c4b88bb93891fe4b81ef51583e9e10bd422a", "reference_id": "ncb-scientific-e7c94f56c83e0651", "scientific_core_sha256": "63f0db688ca1d92f74aa49033266babd73d0ae161097ee8b6fa86d1e494cdc26", "semantic_cluster_id": "ncb-sem-1ccf84c3360dce0e", "target_family": "normative_fmri", "task_ids": ["ncb21-task-2f2394534763a048"]}
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{"aliases": ["normative_fmri_021"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-f84fe6980294c120", "benchmark_track": "scientific", "claim_uid": "ncb-claim-42378af71a5a3ea8", "contract": {"claim_id": "normative_fmri_021", "covariates": ["age", "sex", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_Cont_Default_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, is higher cognition associated with altered connectivity between default-mode and control networks (fc_fc_Cont_Default_z), adjusting for age and sex?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f84fe6980294c120bccc3de4d0ceb634edd5c41e1166cc53760b2275e4bae482", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "f84fe6980294c120bccc3de4d0ceb634edd5c41e1166cc53760b2275e4bae482", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_021", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "In HCP_DISC, with replication in HCP_REP, is higher cognition associated with altered connectivity between default-mode and control networks (fc_fc_Cont_Default_z), adjusting for age and sex?", "question_sha256": "96aee9e4045df0936dc512090197b1714506d8f70e189d6949dfa3665e906cc9", "reference_id": "ncb-scientific-f84fe6980294c120", "scientific_core_sha256": "d3f54a93a9fe0f4de197f479c2784ef3b1da89ac5afb83c2eb70ee9ab7a8016f", "semantic_cluster_id": "ncb-sem-42378af71a5a3ea8", "target_family": "normative_fmri", "task_ids": ["ncb21-task-29f2629513c4d93d"]}
{"aliases": ["cognition_fc_hcp_hcpa"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-f8671ab0121baaa8", "benchmark_track": "scientific", "claim_uid": "ncb-claim-95e7b3c2dfa3871c", "contract": {"claim_id": "cognition_fc_hcp_hcpa", "covariates": ["age", "sex", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_", "predictor": "phen_fluid_composite", "region_set": "functional_connectivity_network_pairs", "type": "association", "unit": "brainwide"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For cognition association with FC descriptors in fMRI-FC, using HCP as discovery and HCP_Aging as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "f8671ab0121baaa8a5791c0e10045747b694a1ce29f748624f86d9f6afaec0a9", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "f8671ab0121baaa8a5791c0e10045747b694a1ce29f748624f86d9f6afaec0a9", "provenance": [{"prior_label": "underpowered_small_positive", "source_citation": "Marek et al. 2022 Nature", "source_collection": "legacy_scientific", "source_id": "cognition_fc_hcp_hcpa", "source_mode": "literature", "source_path": "data/claims/fixed_literature_claims.csv", "target_family": "normative_fmri"}], "question": "For cognition association with FC descriptors in fMRI-FC, using HCP as discovery and HCP_Aging as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "question_sha256": "9047b496d924c1c2397801662673cb5f7b1030b6b878998283c7e84f0611f8f0", "reference_id": "ncb-scientific-f8671ab0121baaa8", "scientific_core_sha256": "a8d3ed25fa38d19265c7e5a65dad409a2b90997b3b0600ed24802f4e8954bc76", "semantic_cluster_id": "ncb-sem-95e7b3c2dfa3871c", "target_family": "normative_fmri", "task_ids": ["ncb21-task-025c8e1301361564"]}
{"aliases": ["normative_fmri_046"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-fa6a1c43897de76e", "benchmark_track": "scientific", "claim_uid": "ncb-claim-b75975463df8369d", "contract": {"claim_id": "normative_fmri_046", "covariates": ["age", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Limbic_Limbic_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across HCP_DISC and UKB_DISC, with replication in HCP_REP and UKB_REP, do females and males differ consistently in limbic within-network connectivity (fc_fc_Limbic_Limbic_z), adjusting for age and cognition within each cohort?", "replication_cohorts": ["UKB_DISC", "HCP_REP", "UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "fa6a1c43897de76e60daf3159b1f4d138da5c3e379097711d345459c92618fe6", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "fa6a1c43897de76e60daf3159b1f4d138da5c3e379097711d345459c92618fe6", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_046", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "Across HCP_DISC and UKB_DISC, with replication in HCP_REP and UKB_REP, do females and males differ consistently in limbic within-network connectivity (fc_fc_Limbic_Limbic_z), adjusting for age and cognition within each cohort?", "question_sha256": "319414901077be52a5f705ad7452c40d360db1bfc69a5605d757faee77fcd736", "reference_id": "ncb-scientific-fa6a1c43897de76e", "scientific_core_sha256": "7302324507950f9bff7f6068131378db7a5861e8bf2b8604eff96a54d139def5", "semantic_cluster_id": "ncb-sem-b75975463df8369d", "target_family": "normative_fmri", "task_ids": []}
{"aliases": ["adhd_q018"], "alignment_disposition": "aligned_with_safety_augmentation", "benchmark_case_id": "ncb-scientific-fa88cbf43e33f82f", "benchmark_track": "scientific", "claim_uid": "ncb-claim-5197f47ccefe760c", "contract": {"claim_id": "adhd_q018", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Limbic_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, do participants with any ADHD diagnosis (dx in {1,2,3}) show altered Limbic-Default connectivity (fc_fc_Default_Limbic_z) compared with controls (dx=0), with no additional covariates, and is the result directionally consistent in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "fa88cbf43e33f82fcef46c1858dd805b62032cbff227c248bd865d0b9f056574", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "fa88cbf43e33f82fcef46c1858dd805b62032cbff227c248bd865d0b9f056574", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q018", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "In ADHD200_DISC, do participants with any ADHD diagnosis (dx in {1,2,3}) show altered Limbic-Default connectivity (fc_fc_Default_Limbic_z) compared with controls (dx=0), with no additional covariates, and is the result directionally consistent in ADHD200_REP?", "question_sha256": "3e90e662beb1ef3d425a7ae84472ad06809ce7db9af7a4002ad6993cc9853257", "reference_id": "ncb-scientific-fa88cbf43e33f82f", "scientific_core_sha256": "8842fa401b2ad25bd7c2028318d7bace4343ab78f0bcb2e4a4e85ee42da0a6a9", "semantic_cluster_id": "ncb-sem-5197f47ccefe760c", "target_family": "adhd", "task_ids": ["ncb21-task-f2e2f0b7031285ab"]}
{"aliases": ["normative_fmri_050"], "alignment_disposition": "ambiguous_unresolved", "benchmark_case_id": "ncb-scientific-faaaeb165e293001", "benchmark_track": "scientific", "claim_uid": "ncb-claim-950ac04f921ee414", "contract": {"claim_id": "normative_fmri_050", "covariates": ["sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_Cont_Default_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "cohort not in [\"ABCD_DISC\", \"ABCD_REP\"] or dx == \"0.0\"", "question": "Across ABCD_DISC, HCP_DISC, HCP_Aging_DISC, and UKB_DISC, with corresponding replication cohorts, is higher age associated with cohort-dependent differences in default-mode to control-network connectivity (fc_fc_Cont_Default_z), adjusting for sex and cognition within each cohort and restricting ABCD to dx=0.0?", "replication_cohorts": ["HCP_DISC", "HCP_Aging_DISC", "UKB_DISC", "ABCD_REP", "HCP_REP", "HCP_Aging_REP", "UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "faaaeb165e29300168533c3f46df10bc022f709f42e5ae34a3f8f39f6583b00b", "migration_status": "ambiguous_unresolved", "modality": "fMRI-FC", "pre_v2_contract_sha256": "faaaeb165e29300168533c3f46df10bc022f709f42e5ae34a3f8f39f6583b00b", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "normative_fmri_050", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "normative_fmri"}], "question": "Across ABCD_DISC, HCP_DISC, HCP_Aging_DISC, and UKB_DISC, with corresponding replication cohorts, is higher age associated with cohort-dependent differences in default-mode to control-network connectivity (fc_fc_Cont_Default_z), adjusting for sex and cognition within each cohort and restricting ABCD to dx=0.0?", "question_sha256": "0c7a9c8fdb396956aa6224ea025fab911af0f46bc4c1977ef9b02349d2e59bb9", "reference_id": "ncb-scientific-faaaeb165e293001", "scientific_core_sha256": "c040543d7757cea52bc46bb0a60d9de7dc21541207b38d7e4fbbed86f0679a59", "semantic_cluster_id": "ncb-sem-950ac04f921ee414", "target_family": "normative_fmri", "task_ids": []}
{"aliases": ["adhd_q047"], "alignment_disposition": "aligned", "benchmark_case_id": "ncb-scientific-feb70aa94fa7c90f", "benchmark_track": "scientific", "claim_uid": "ncb-claim-8735a48780a17800", "contract": {"claim_id": "adhd_q047", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ABCD_DISC and ADHD200_DISC, using each cohort's available ADHD-control coding separately (ABCD dx=1.0 vs 0.0 excluding missing dx; ADHD200 dx in {1,2,3} vs 0), is the ADHD association with Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z) in the same direction, with no additional covariates?", "replication_cohorts": ["ADHD200_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "feb70aa94fa7c90fa2df8c05f733ba5d944a5de106a49eb36eb63cbfa0415e66", "migration_status": "ready", "modality": "fMRI-FC", "pre_v2_contract_sha256": "feb70aa94fa7c90fa2df8c05f733ba5d944a5de106a49eb36eb63cbfa0415e66", "provenance": [{"prior_label": "candidate_unknown", "source_citation": "llm_proposed", "source_collection": "stage2_current", "source_id": "adhd_q047", "source_mode": "llm_proposed", "source_path": "review-stage/confirm-gates-all-gpt55/combined_benchmark_results.json", "target_family": "adhd"}], "question": "Across ABCD_DISC and ADHD200_DISC, using each cohort's available ADHD-control coding separately (ABCD dx=1.0 vs 0.0 excluding missing dx; ADHD200 dx in {1,2,3} vs 0), is the ADHD association with Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z) in the same direction, with no additional covariates?", "question_sha256": "8b63ca6230fea2f14399ec682f45c8c5b098b159b529849780b7bac031ce5ac8", "reference_id": "ncb-scientific-feb70aa94fa7c90f", "scientific_core_sha256": "f5ac6bbdb3a6e7f198712152259b8996498b8a69dd1a301e6fae213e1d03f000", "semantic_cluster_id": "ncb-sem-8735a48780a17800", "target_family": "adhd", "task_ids": ["ncb21-task-a71d3a3c1b344c50"]}
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