{"benchmark_case_id": "ncb-synthetic-stress-45b6d43ce4f879ea", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_abide1_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_abide1_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_within_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_abide1_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "discovery_only"}}, "contract_sha256": "45b6d43ce4f879ea6a44edaca6f370c52e8a56c964096e1d0e3518533e00d0c5", "dataset_id": "neg_p_fishing_abide1_s1", "discovery_cohort": "neg_p_fishing_abide1_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_abide1_s1_DISC": "d149229cabf3622aabe60a88f8fd2ccba8a1bababb8a89f9588298cbda47f01e", "neg_p_fishing_abide1_s1_REP": "cf8067788142e3b759f3ce04dd1b88185ea04ac164d681c3044a7e1f456389a7"}, "partition_paths": ["neg_p_fishing_abide1_s1_DISC", "neg_p_fishing_abide1_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_abide1_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "226513fcade7d0f81767cc05d3d032ff3cb6f2f898ae3879784117c97b009dd7", "task_id": "ncb21-task-00309f172caa8af0"}
{"benchmark_case_id": "ncb-scientific-7c173adc5485d7ce", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_016", "covariates": ["age", "sex", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, is higher cognition associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and sex?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7c173adc5485d7ce2f944c400dd42b6053d003a6972c57de7cbc05bac07157ce", "dataset_id": "HCP", "discovery_cohort": "HCP_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["HCP_DISC", "HCP_REP"], "question_sha256": "1f7bc67d179b9355b46c0a6d219801071d9b65cbb77303c00ba2f5be300fd9ba", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "540d98230b1a41f0cbf3a89cf455d7b2e7d7f5758a5b8f3eabe614de97214019", "task_id": "ncb21-task-009b694780a8795f"}
{"benchmark_case_id": "ncb-synthetic-stress-c752b6285a527e82", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_adni_fmri_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_adni_fmri_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Default", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_adni_fmri_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c752b6285a527e8231952fa9dd8f1fa0c3698a01888f7d20abd15a0071d10017", "dataset_id": "neg_random_label_adni_fmri_s3", "discovery_cohort": "neg_random_label_adni_fmri_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_adni_fmri_s3_DISC": "a2745e3a3f004471c0c1cb52a86b1540bce9cf385632aa25133c44ece3d8ea45", "neg_random_label_adni_fmri_s3_REP": "2662793cdb5419ddc322ddd6d5f95ffce2abbc87104f23b94794aff3049d8ccf"}, "partition_paths": ["neg_random_label_adni_fmri_s3_DISC", "neg_random_label_adni_fmri_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_adni_fmri_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5fcaca4c8cf1ce57a65f3e7e56a0e6c135ecbc5263f575259f3ea31ae7e85467", "task_id": "ncb21-task-01e4680be5d29eea"}
{"benchmark_case_id": "ncb-scientific-c1b8f2bee08cd388", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_033", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher age associated with lower default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for sex and cognition?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c1b8f2bee08cd3885ae393bad4189abe4f6f306525a43073ef666674c49e6e5a", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "bbb2f5d0337d98ca21d01363117c8802166d00564d52138fc36095d6b7896a14", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "8c0792a412bce1cdbee17765d082e161d376aeeb834a9e479c512f09a5e9ac72", "task_id": "ncb21-task-0244deeb8ae44e7b"}
{"benchmark_case_id": "ncb-scientific-f8671ab0121baaa8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "cognition_fc_hcp_hcpa", "covariates": ["age", "sex", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_", "predictor": "phen_fluid_composite", "region_set": "functional_connectivity_network_pairs", "type": "association", "unit": "brainwide"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For cognition association with FC descriptors in fMRI-FC, using HCP as discovery and HCP_Aging as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "f8671ab0121baaa8a5791c0e10045747b694a1ce29f748624f86d9f6afaec0a9", "dataset_id": "HCP", "discovery_cohort": "HCP_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_Aging_REP": "e4682154e236a020f91b7932fe75341cf7a0eed865089e5172cad83a6989e965", "HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8"}, "partition_paths": ["HCP_Aging_REP", "HCP_DISC"], "question_sha256": "9047b496d924c1c2397801662673cb5f7b1030b6b878998283c7e84f0611f8f0", "replication_cohorts": ["HCP_Aging_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a8d3ed25fa38d19265c7e5a65dad409a2b90997b3b0600ed24802f4e8954bc76", "task_id": "ncb21-task-025c8e1301361564"}
{"benchmark_case_id": "ncb-external-transfer-3ecc90fbaac44bfe", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_precentral_random_label_s20260733", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_precentral", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_ad_precentral.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ac14eb752018c2b066fd270067a2c6e97d60ece296274f08e5f792c27a25fb20", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "64373257a695f2e7bef2831eee286d95a98c412af547ccea7a08e2c3be7a6d6a", "selected_assignment_rows_sha256": "df26c25463bd81d64ebd3f445930c18f9ab2b780b58c3de6db31bd93328bfaad"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "df26c25463bd81d64ebd3f445930c18f9ab2b780b58c3de6db31bd93328bfaad", "discovery_seed": 20260733, "group_column": "ncb_random_group", "parent_external_claim_id": "ad_precentral", "replication_seed": 21260733, "seed": 20260733, "selected_assignment_rows_sha256": "df26c25463bd81d64ebd3f445930c18f9ab2b780b58c3de6db31bd93328bfaad", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "633b7a60ce7053b270c5f84c3f9d1de863f22ad507e42202836c71efb0a5b094", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "38b900d5a98b3c1650efbd0ff6889581ced40cbf20677f55480f994bf9ce73a2", "task_id": "ncb21-task-02aad5d5f16fb6aa"}
{"benchmark_case_id": "ncb-scientific-822a9e3fd7a9cc40", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q010", "covariates": [], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_DISC, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted dx-only comparison with no covariates?", "replication_cohorts": ["COBRE_REP", "BSNIP2_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "822a9e3fd7a9cc40dd56cec27d9df1f4b981c6e08141b1a8a2264fd39544ccfa", "dataset_id": "COBRE", "discovery_cohort": "COBRE_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "COBRE_DISC": "f53b3405d06487a9d268b89165605cc0ed60d2c3a68e41f8ebe73660d9916d79", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "COBRE_DISC", "COBRE_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "question_sha256": "12a8c450b03a4679a3e072cde7a58e39e04305d3c757da795decf192427eee60", "replication_cohorts": ["COBRE_REP", "BSNIP2_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "43db2903fcd2c7cf75d1afce572d56970f4a5132c8798cdbd84893fa8c6f9c97", "task_id": "ncb21-task-02b88fc3865fef3e"}
{"benchmark_case_id": "ncb-external-transfer-ddd73764077ec103", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_bd_caudate", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "BIPOLAR", "control": "CONTROL", "var": "dx"}, "outcome": "smri_caudate", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_caudate two_sided for BIPOLAR compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ddd73764077ec10348da93d1d35e97680ce187d09150a66d48ab1c7ca7d700bd", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "cb507c12e98e0c48a27fd4dac9ed7e9597c60339ee4580cb500632786f9cd015", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "825fb3312dd5db1f50191822ae66cec1ac6b81fb4e699c4440c3a455b5c848a0", "task_id": "ncb21-task-02f91dae643fb08f"}
{"benchmark_case_id": "ncb-scientific-a20d5751ea756186", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_midtemp_atrophy_adni_oasis3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_midtemp", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For AD middle temporal atrophy in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a20d5751ea756186d20b808bb6f95bf13e0bc956ea37bccdfd0404d9233947ed", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "27b894055f88f8bc33ad7398a202e6882cd2c1be7d493aa9dceb5843f2db3ff2", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4f22eb39dbbd4c8a46fa72c57641762827f42d7e6850cffa6e200dddec96434b", "task_id": "ncb21-task-03389888b8f63226"}
{"benchmark_case_id": "ncb-synthetic-stress-7fcbe86bd9b2c850", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_ukb_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_ukb_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_ukb_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7fcbe86bd9b2c85025577f69009886d133c5049569e5bc5bd234ca2ffb31a7e8", "dataset_id": "neg_random_label_ukb_s2", "discovery_cohort": "neg_random_label_ukb_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_ukb_s2_DISC": "b01e8bcf08d8765412341cf8bc24409c834a37d40ae5e3be314348388f0ab9f7", "neg_random_label_ukb_s2_REP": "ce80269ad3d6cea6229d317b51ad72e92c24205648e654d7d3cc9a4e698e91e6"}, "partition_paths": ["neg_random_label_ukb_s2_DISC", "neg_random_label_ukb_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_ukb_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "0afa5bae3cdff1cfd20f801b890b8c62c54b0bceb9094efbea2ed86d12ae9440", "task_id": "ncb21-task-034634bca9728653"}
{"benchmark_case_id": "ncb-synthetic-stress-6ee77e7e1b81ebdc", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_ukb_s3", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_ukb_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_ukb_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6ee77e7e1b81ebdc9c4d1d64f1ff8fc41f13827e444d89861719541b33f6be83", "dataset_id": "neg_site_confound_ukb_s3", "discovery_cohort": "neg_site_confound_ukb_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_ukb_s3_DISC": "2a490ff524957d8318c60a77c16c0476f7508f39a14f9cb8466a2157b9b07dd5", "neg_site_confound_ukb_s3_REP": "140a0738094eaecd3f837c678ce7fdb6694b1f837a86bce46cf47aeb586bcd21"}, "partition_paths": ["neg_site_confound_ukb_s3_DISC", "neg_site_confound_ukb_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_ukb_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "bbaca04f5f93b791e9a713f312265a2d4cd0ed70208123f4dba8dcd918e87988", "task_id": "ncb21-task-04c30ff0d802c156"}
{"benchmark_case_id": "ncb-synthetic-stress-0558f914b0d8e6af", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_hcp_aging_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_hcp_aging_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Default", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_hcp_aging_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0558f914b0d8e6af1cc80c25d87ae31dbf6d3c1644b91c484700b940bdebecfa", "dataset_id": "neg_random_label_hcp_aging_s3", "discovery_cohort": "neg_random_label_hcp_aging_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_hcp_aging_s3_DISC": "bbeaab5c5efa2d6f4a9c27dd1e793c4442daa1deebc58c21b9267cefaf573d90", "neg_random_label_hcp_aging_s3_REP": "2f42bdd000b090f57d92992edd32e08c83eb99ba091ed4d5b8c0f31999f47178"}, "partition_paths": ["neg_random_label_hcp_aging_s3_DISC", "neg_random_label_hcp_aging_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_hcp_aging_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f55822497d3d317b6951b21f635480be2a35ccb4ea3df8f688cd8d653644646f", "task_id": "ncb21-task-04fa81db8cc4cf61"}
{"benchmark_case_id": "ncb-external-transfer-530077d063ef312f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_adhd_caudate", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "ADHD", "control": "CONTROL", "var": "dx"}, "outcome": "smri_caudate", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_caudate negative for ADHD compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "530077d063ef312f6a683fe9a1bfff83b60f53404def8517eeb191797806f8f2", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "18b4a7fabf4d335faf8a3f74ae4791c1c20d84274d426247357234d25068fed3", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1130cba58fa8ba2235334d8598646ec0c2861984c9bbc44e7ceae9cedc4f32d1", "task_id": "ncb21-task-056b7bd49e634bc6"}
{"benchmark_case_id": "ncb-synthetic-stress-7320409f0609fb6c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_oasis3_fmri_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_oasis3_fmri_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Default_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_oasis3_fmri_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "7320409f0609fb6cb4c4904f0ab2003f4a13ce947da5f756bc7292a0b7f6f487", "dataset_id": "neg_p_fishing_oasis3_fmri_s3", "discovery_cohort": "neg_p_fishing_oasis3_fmri_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_oasis3_fmri_s3_DISC": "724e1b1e4057a7ccc7a941014fe7296696225ad364145c80b2473905dbd403cb", "neg_p_fishing_oasis3_fmri_s3_REP": "3984130017ec409fce722aa4f1a31d4beaab08b059d51e0b69cc1621e96719a8"}, "partition_paths": ["neg_p_fishing_oasis3_fmri_s3_DISC", "neg_p_fishing_oasis3_fmri_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_oasis3_fmri_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "df1a0b452463b075ebe8a9cc5e7d235292c773c0c7af8f2ef48d698dd1b63960", "task_id": "ncb21-task-05a3373bee2fa7be"}
{"benchmark_case_id": "ncb-scientific-a36ed4355870c674", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_fdg_hypometabolism_adni", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "pet_fdg_suvr", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For AD FDG hypometabolism in PET, using ADNI as discovery, test the claim with expected direction negative and adjust for age;sex when available.", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a36ed4355870c67495b9c1642246c88e628f924a40b61dcf3dc95742bd0f7c0b", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6"}, "partition_paths": ["ADNI_DISC", "ADNI_REP"], "question_sha256": "56be5325b4e73bd57c10e849d6dab1725eff973e263b44fe8b6aa56c29fe3547", "replication_cohorts": ["ADNI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "331c26efa5688b437e6263e8f8e0a90dfcd67164a28ad459d05962ee91067e36", "task_id": "ncb21-task-06ebe3ba5846d880"}
{"benchmark_case_id": "ncb-scientific-531f4a09678d2222", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q044", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_SomMot_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "531f4a09678d2222e7dfb2b3f2c5e270ea361cb4ff770d5a532b98fb51322082", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "9b145e733c73d43246239a62c9bade15c159bba88cda626c465b0b37b812fd8c", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7cc6cef044e76528cc0772c526b9302237c8c48fded67bd9e0f31180eaea22e1", "task_id": "ncb21-task-072a14c8383581f4"}
{"benchmark_case_id": "ncb-external-transfer-ec4fe05bc8c819f7", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_cerebellum", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_cerebellum", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_cerebellum negative for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ec4fe05bc8c819f77f52fc16c1b49bfb65baae47ab32e076bac1d954680a7599", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "f4395d06c9578d1034e9abe5d06d2827e70ee292be7e98cd9e834f1288ffbc67", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7867cbb4931ef3eac36a20f6adf884612cde515eb30acd242d91041df9936f8b", "task_id": "ncb21-task-07ed20b971d64049"}
{"benchmark_case_id": "ncb-scientific-8875a7bf33df9519", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q008", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with higher Salience/VentralAttention-Somatomotor connectivity (fc_fc_SalVentAttn_SomMot_z), with no additional covariates, and is the same direction seen in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "8875a7bf33df951977e26ecd4ecf5885a3a6e08b889d220be4400f20649c8706", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "042de82b6e180575d97e5abc72a24dcbb9d282effef3e184634dd3d8f6251552", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7e6d38439f6ee87030614990e069263200ba1b75ef2ffc9fa29f6ae8356d6e15", "task_id": "ncb21-task-084549e934cf6e3a"}
{"benchmark_case_id": "ncb-synthetic-stress-ee7abc3b89d1d4cc", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_ukb_s2", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_ukb_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_ukb_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ee7abc3b89d1d4cc719a3b0498d67a66e45a832af89ebc4a0f2bb6ef847882fe", "dataset_id": "neg_underpowered_ukb_s2", "discovery_cohort": "neg_underpowered_ukb_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_ukb_s2_DISC": "afdd009d8d384c23fcac95946e9767ae2cbf051730609bb198190bd8e77dc592", "neg_underpowered_ukb_s2_REP": "b62104ae48cf1bd1f8ede8456b6ccecd38db25d685fc0a43e4ceb2c1a47a1070"}, "partition_paths": ["neg_underpowered_ukb_s2_DISC", "neg_underpowered_ukb_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_ukb_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a61ffe243ca4330aa54cb90f4f8852e7c7961dfe9a1b3ccaeefa879284795967", "task_id": "ncb21-task-087634b4ab4aa55a"}
{"benchmark_case_id": "ncb-synthetic-stress-7fbc16c903db656b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_abcd_s3", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_abcd_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_abcd_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7fbc16c903db656baee07961664428e3f359c3b2a9b6dbfbd5663c7b0b4f2f18", "dataset_id": "neg_site_confound_abcd_s3", "discovery_cohort": "neg_site_confound_abcd_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_abcd_s3_DISC": "cc1a8d8b881249e436bc62cdc951d916cbd0e40e6b2618d0cfd483ea69532dcb", "neg_site_confound_abcd_s3_REP": "2f51effaf8e258e7f2e388163491928e9ede8908ee8b30ba81eeaaba797cfb5f"}, "partition_paths": ["neg_site_confound_abcd_s3_DISC", "neg_site_confound_abcd_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_abcd_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f5511dfd0eadf0fe3a9c168747311b8bff7a7d4bb0709bae70f88005db8b60ee", "task_id": "ncb21-task-08b236935af05ed0"}
{"benchmark_case_id": "ncb-scientific-d4c0b42a60357a5d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q011", "covariates": ["age", "sex", "site"], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_DISC, is fc_within_network lower in SZ than HC in an unadjusted group comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d4c0b42a60357a5d939e12105a02798899968bed182f8471def699471bf39842", "dataset_id": "COBRE", "discovery_cohort": "COBRE_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"COBRE_DISC": "f53b3405d06487a9d268b89165605cc0ed60d2c3a68e41f8ebe73660d9916d79", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc"}, "partition_paths": ["COBRE_DISC", "COBRE_REP"], "question_sha256": "268874f0caddc32a56475d579d3e315fac40387f7bec01ff2964398e0b3bf634", "replication_cohorts": ["COBRE_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "edd521086383f67cc2d26e964127ebbf406e84c4db92d7bde5aa6226cc4c28a6", "task_id": "ncb21-task-08c01f90e76c8f85"}
{"benchmark_case_id": "ncb-synthetic-stress-81bc0f58011fdf7d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_fbirn_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_fbirn_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_within_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_fbirn_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "81bc0f58011fdf7ddb6089d83c1f2d20752e7fb5e63c59a1d606357af3bdc882", "dataset_id": "neg_random_label_fbirn_s3", "discovery_cohort": "neg_random_label_fbirn_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_fbirn_s3_DISC": "c612e7a5485b2c640d40a6e053d23246711bdbb4f8cde75a1c81984ab0e3fe34", "neg_random_label_fbirn_s3_REP": "db3b17771487aea555cb023745a14681a2751e893380a0cc94fd914c8f76212f"}, "partition_paths": ["neg_random_label_fbirn_s3_DISC", "neg_random_label_fbirn_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_fbirn_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d9c6fb5212944f2a3eed5f52ca32bfd75b1c332c6c32ed82bdf896389041d28c", "task_id": "ncb21-task-0941644e02f5107d"}
{"benchmark_case_id": "ncb-scientific-4f6f45a81e8e3370", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_42141307_pmid42141307_asd_fmri_fc_casecontrol_mixed", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "fMRI-FC network-pair connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.6, "harmonize": "combat", "pattern_corr_min": 0.6, "region_replication_frac_min": 0.6, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded idiopathic autism diagnosis versus neurotypical control status effect on functional connectivity dysconnectivity in fMRI-FC, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "4f6f45a81e8e337049763733e2b9871efc22c4d9fc5f5f6d4ccf920cb8a023d6", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "a3b0a5385d5c5cb57ffe2a1beeebcac6d75eea4a7cd36db68b07e4b2378e8048", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b9771be35668573640eb777a1bc873d014c162f60a7a3f8cc6f201cdfc2091cd", "task_id": "ncb21-task-09b5e9d053af98b1"}
{"benchmark_case_id": "ncb-scientific-cc2914e36309cad4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q025", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_midtemp", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with lower smri_midtemp than CN, adjusting for age and sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cc2914e36309cad42e9bff4b0a6351fa56b156cb121cb9074b25063a25f3fff5", "dataset_id": "OASIS3", "discovery_cohort": "OASIS3_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_DISC": "8a048aaff562775d7c80f7027c9d8bb56cc738b7563d25ca06af7cb33df89d31", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["OASIS3_DISC", "OASIS3_REP"], "question_sha256": "d325e8268a83c8fa1541ef6341c812f8d9c73d2eac79f89951e182a9591e7688", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "3ad59694b84444ecb7f263e017fbe73bd62dd8beaaa1603c826756e4ba546c5b", "task_id": "ncb21-task-0a1ed327c94ac9a5"}
{"benchmark_case_id": "ncb-scientific-79182620041b5799", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q046", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADNI_fMRI_REP", "estimand": {"direction": "negative", "group": {"case": "1.0", "control": "0.0", "var": "dx"}, "outcome": "fc_fc_Default_Default_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ADNI_fMRI_REP, excluding participants with missing diagnosis code, is diagnosis code 1.0 associated with lower fc_fc_Default_Default_z than diagnosis code 0.0, adjusting for age and sex?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "79182620041b57998eb9b3eb81cfba653f320fbe529ff0db654dd813626d0e36", "dataset_id": "ADNI_fMRI", "discovery_cohort": "ADNI_fMRI_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c", "ADNI_fMRI_REP": "77b228db80400e42457cdc1a715f338fa645e8901922ef5f6f7c7f7d3d176c13"}, "partition_paths": ["ABCD_REP", "ADNI_fMRI_REP"], "question_sha256": "61757c25b7c125d383d1baa9fdfa79fd6b92139fdbbf27541766ed623ccc8900", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "aefeb590084f636e3cdc8b4b54ca7e32c7b6ae8b45ccd2497b344758ad3a0091", "task_id": "ncb21-task-0a3153ea01de1eb9"}
{"benchmark_case_id": "ncb-scientific-1f13a7aee9fc1c7d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q034", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_SalVentAttn_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1f13a7aee9fc1c7dc1187efe86c3068be853653eb4050183fac5bcb492b8bbe3", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "a7582fe59f3c1108a53f9b0392fd54e28cdc347df002104cb19fb7806e102792", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5c76af45d23092631c50ee88c6fcd4b5d65aa5ec8d2737b6a44a22dd566283f5", "task_id": "ncb21-task-0a70018376a8881b"}
{"benchmark_case_id": "ncb-scientific-d3b9d78a966173c6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q019", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_DorsAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_DorsAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d3b9d78a966173c6a58a5b8ed01a0316ad73601092701d1310f08cee0928e62e", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "41065d358cb9078ccbb06422c2694f7cfad4dfbcfda49f6ca8be7b03e1235ffc", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "cdc0a3e3583d3137226e1f9d0fb6a7262fea7ce6e2b83140279b21a1c58830af", "task_id": "ncb21-task-0aedc228888c5eae"}
{"benchmark_case_id": "ncb-synthetic-stress-f936b668e13706b3", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_hcp_aging_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_hcp_aging_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_DorsAttn", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_hcp_aging_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "f936b668e13706b3a994ce4d4f82af08dd33fdc77b446162789c55cb8d4060b1", "dataset_id": "neg_p_fishing_hcp_aging_s2", "discovery_cohort": "neg_p_fishing_hcp_aging_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_hcp_aging_s2_DISC": "fd94e38caeec55fb07ad6cafb5a710ce1f7971244123a451f9aaae2733fa3907", "neg_p_fishing_hcp_aging_s2_REP": "b444b5a03b57b64d5892464692ca6ea1b8c00111ece06d3b2410c0ccff95a176"}, "partition_paths": ["neg_p_fishing_hcp_aging_s2_DISC", "neg_p_fishing_hcp_aging_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_hcp_aging_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "678b811ca38c5839fc21f7a39a66f7c8cb6002e1949a381d46eabb7aefba6725", "task_id": "ncb21-task-0b173883f31dedd8"}
{"benchmark_case_id": "ncb-scientific-91575e683551f750", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q046", "covariates": [], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": ["fc_fc_Cont_Default_z", "fc_fc_Cont_Default"], "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 2, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, does any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) relate more strongly to z-transformed Control-Default connectivity (fc_fc_Cont_Default_z) than to the corresponding untransformed measure (fc_fc_Cont_Default), using no additional covariates, and is the pattern checked in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 2, "selection": "preregistered"}}, "contract_sha256": "91575e683551f75081c4f506c9039447b9776b05e7c95ff1bf81a2323f0c51b9", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "5e68e8432ce7444392ec81f9d01c5b1f2d73c5553440f48dd91e84d651415103", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6d2541ee6dd8bf4afa27a8e154b7ab93c2e6c9948532754a5f049da9244adaa3", "task_id": "ncb21-task-0b3199bf9e229ded"}
{"benchmark_case_id": "ncb-scientific-25e7ef2da7f86162", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_008", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_SomMot_Vis_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with altered connectivity between somatomotor and visual networks (fc_fc_SomMot_Vis_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "25e7ef2da7f86162e17db3c87a2a749b660109283b81fcff23254154c04df77b", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3", "UKB_REP": "6da6a67cb610290a28f97b077dd2aa0e82c39161e4b3c622857cb54843df2357"}, "partition_paths": ["UKB_DISC", "UKB_REP"], "question_sha256": "a8a905b9783b229f4ecd04dd95f62381cccb2c1461d6de7a1fb057aa329dc761", "replication_cohorts": ["UKB_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "24a1fc94b0198ab1e628a030ca21686ce99371176d0dffce4015fc8e04973543", "task_id": "ncb21-task-0c8a0e13f677ff47"}
{"benchmark_case_id": "ncb-synthetic-stress-f091755e09ca7583", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_abide1_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_abide1_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_between_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_abide1_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "discovery_only"}}, "contract_sha256": "f091755e09ca7583a68c850c45d40be12c983bb4d8b7fd45db2f486f3cd3585a", "dataset_id": "neg_p_fishing_abide1_s3", "discovery_cohort": "neg_p_fishing_abide1_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_abide1_s3_DISC": "a84eaf0463d144d4db891d78c5bd03aacc8a325757010c4ad91c518c990cdd63", "neg_p_fishing_abide1_s3_REP": "ad19d2c23418027ead90e99beb84e762b250760915f33b05bde467154e28a5b9"}, "partition_paths": ["neg_p_fishing_abide1_s3_DISC", "neg_p_fishing_abide1_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_abide1_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "952929cfd0cac7f148df42960c659ec003730674abec25c2b0305fb8191b45a7", "task_id": "ncb21-task-0c9246076c5951c0"}
{"benchmark_case_id": "ncb-scientific-3ba54e0248b29adb", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q030", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_SalVentAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Limbic_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3ba54e0248b29adb223a15306b37f76fc0e2b932fed74e86bd845de4c1fb2ee8", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "f457824aa9838d8a64dbad1840052b2af6b449c8a3de005af65756ab4bb14f6a", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "eb87f9570188517daaae7d91022e5fc26302a3db081ce8d96b2880bb1e6bf71e", "task_id": "ncb21-task-0d6282b64ac621ac"}
{"benchmark_case_id": "ncb-scientific-4cedbc48040eac27", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q005", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_REP, is SZ associated with lower fc_mean_positive than HC in an unadjusted group comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["ChineseSZ_REP", "FBIRN_REP", "COBRE_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "4cedbc48040eac27d2eaf9fa5cbc4713fa67c79a232f498107862a2fe7d63e79", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "question_sha256": "f26b3bdeb4deae8bacabd7e4ff1a21263ad771773635335f9175bde26420c892", "replication_cohorts": ["ChineseSZ_REP", "FBIRN_REP", "COBRE_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "61f2835238cc81613f9a40a7ac6efacc2311cb56f17eb0a6d3f8a1e19698977b", "task_id": "ncb21-task-0e2008c7cc9b82ba"}
{"benchmark_case_id": "ncb-scientific-709359ed74346ba9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q004", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_wholebrain", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with lower smri_wholebrain than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "709359ed74346ba923d40ae723b35bed48eb991fabd54079128ed09c43fa3f32", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6"}, "partition_paths": ["ADNI_DISC", "ADNI_REP"], "question_sha256": "98db6d838abbfef60a3014ae8e5e2dbc8e8fdad24891976bc77609469aafe0d5", "replication_cohorts": ["ADNI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c5b64d814a398d2ea4d245546508c07d896549477db41ae2a97df760b309b3c0", "task_id": "ncb21-task-0e9b04ade45505c5"}
{"benchmark_case_id": "ncb-synthetic-stress-1856779cf86705e9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_adni_s1", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "neg_site_confound_adni_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_entorhinal", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_adni_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1856779cf86705e92103386db48c5ddab8e563068c09f0ddec81e2554399db8d", "dataset_id": "neg_site_confound_adni_s1", "discovery_cohort": "neg_site_confound_adni_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_adni_s1_DISC": "28d7dc4456992efa76d5e60a13ccecbcd4ffd74c1f9a73458fb30b68165d6441", "neg_site_confound_adni_s1_REP": "85190f24620363773689e48d93ac4e17357f727d534627c5414c8abfa29fb7cc"}, "partition_paths": ["neg_site_confound_adni_s1_DISC", "neg_site_confound_adni_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_adni_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "13965ff423fdcf273421dc724e698110a552e65f4f6ccab422116e21a956cdd2", "task_id": "ncb21-task-0f0dfd7dd1fef57a"}
{"benchmark_case_id": "ncb-external-transfer-87da7810f0a4515f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_postcentral", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_postcentral", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_postcentral negative for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "87da7810f0a4515fd25c6bb74f6a951494e20c38fdf8988d2b3836d369932721", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "3daff46b1e6aee8357aa368c0c57906f78a4c1f9d6a011bb2b81342e0bc0fe40", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a16e4752c36f031cb7a1cf0efe7e6bf237bd8dc9bac573cca4973a876631327f", "task_id": "ncb21-task-101b0d9b0a5af630"}
{"benchmark_case_id": "ncb-synthetic-stress-f91a2cdb84ef6798", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_cobre_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_cobre_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_between_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_cobre_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "discovery_only"}}, "contract_sha256": "f91a2cdb84ef679828302a48102e853414e7f01df13f31bee2b1a2b55b471a71", "dataset_id": "neg_p_fishing_cobre_s1", "discovery_cohort": "neg_p_fishing_cobre_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_cobre_s1_DISC": "7511257c444948803a692b5b9e4f4413972a3777b63793136cb1eecd71b6b9f9", "neg_p_fishing_cobre_s1_REP": "5d65dc72b7fde4622014f54fc201cb957f7231307a9066d313196ef41100bbbe"}, "partition_paths": ["neg_p_fishing_cobre_s1_DISC", "neg_p_fishing_cobre_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_cobre_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "170f402aa2251373e130866ef28dd972d39b31ede23fc2a690d4329b085d8e45", "task_id": "ncb21-task-10879e6df75209dd"}
{"benchmark_case_id": "ncb-synthetic-stress-792cb959ece29063", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_hcp_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_hcp_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Limbic_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_hcp_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "792cb959ece29063d5cd098aad2fc1840f768fff87a7725930a01e6dbd155c04", "dataset_id": "neg_p_fishing_hcp_s1", "discovery_cohort": "neg_p_fishing_hcp_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_hcp_s1_DISC": "ca41daf6c50026408e2735f82f44aa02ff9ef4779bd0e735879526620219a638", "neg_p_fishing_hcp_s1_REP": "79484449ffc2c8b4adb304e20e9c98715a740f87108e4a0c48d1e3fc24ac29d1"}, "partition_paths": ["neg_p_fishing_hcp_s1_DISC", "neg_p_fishing_hcp_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_hcp_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "0641efebf127f44e5d79a95276ef2904dc450e390c658285b2178837feb4dcc3", "task_id": "ncb21-task-112b180189fb0cc4"}
{"benchmark_case_id": "ncb-synthetic-stress-dd4beff29754d17d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_adni_fmri_s3", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_adni_fmri_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_adni_fmri_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "dd4beff29754d17da0bae2369f43e6bcee397d5c62cf4461c8e911b9f761df6a", "dataset_id": "neg_underpowered_adni_fmri_s3", "discovery_cohort": "neg_underpowered_adni_fmri_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_adni_fmri_s3_DISC": "1eb156b7aed2672ca1d2f0d78d5d0ead1ab36849ae6706616934ab8dfcfe91f4", "neg_underpowered_adni_fmri_s3_REP": "f666fb4674b6d6b239c384436d87b0866c5cce2915ac812cf66407aced0be0ef"}, "partition_paths": ["neg_underpowered_adni_fmri_s3_DISC", "neg_underpowered_adni_fmri_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_adni_fmri_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "bbe5f60d14289485b6e61ebdb5281207c8d5a64d25b7832ccd3decaae0d38c34", "task_id": "ncb21-task-1196ff0f12a7bd6d"}
{"benchmark_case_id": "ncb-scientific-61274f38e0112edd", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q036", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SomMot_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_SomMot_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "61274f38e0112edde8180b2b74bd970e73a3a503b87528dec8547ff8d39e08d3", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "535c84f3611c6ee5e986210892b96d640bef5506a5df6811d8df0c847b6c21b5", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "60d0918cd31da445f4f6856485f84fa783456f574180a65bcecc0296786ee0e8", "task_id": "ncb21-task-121e269865518790"}
{"benchmark_case_id": "ncb-external-transfer-5f9f5d74554e0614", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_bd_thalamus", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "BIPOLAR", "control": "CONTROL", "var": "dx"}, "outcome": "smri_thalamus", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_thalamus negative for BIPOLAR compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5f9f5d74554e0614286247e539df77c7447f9be85173123171ae3ae0c09a6c6d", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "fc40873185b4f9f779a876ccc611d5fbd3a59b20501bc1d1096453c6ffbbf139", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "89f0da24c7b2ea17d4cb975b00ffaa4eaf9abddca2094c9927c6c72aff277c98", "task_id": "ncb21-task-1248ee49d6b353a8"}
{"benchmark_case_id": "ncb-synthetic-stress-e23fddfb3f829797", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_cross_nonrep_adhd200_abcd_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_cross_nonrep_adhd200_abcd_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_SomMot_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_cross_nonrep_adhd200_abcd_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "e23fddfb3f8297971dcdafa565a08c79aa3ba0e0939f2574436d2c5735ba2af2", "dataset_id": "neg_cross_nonrep_adhd200_abcd_s3", "discovery_cohort": "neg_cross_nonrep_adhd200_abcd_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_cross_nonrep_adhd200_abcd_s3_DISC": "cd87879ee2742ba3849c318b52145e7f1074c369baf569e352a50fb051a7b0be", "neg_cross_nonrep_adhd200_abcd_s3_REP": "3527b7e4ec8722ff7ca0fb78a421374e9f267d2adeb39fd6fa19c0a675a08588"}, "partition_paths": ["neg_cross_nonrep_adhd200_abcd_s3_DISC", "neg_cross_nonrep_adhd200_abcd_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_cross_nonrep_adhd200_abcd_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "bbb3cfc56e95797a5d7eca9a033cffca2298f18a7623b587c3bd1e10830144ff", "task_id": "ncb21-task-12b3608fd0ff5e4d"}
{"benchmark_case_id": "ncb-synthetic-stress-1f7403bea6b8ee84", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_adni_s2", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_p_fishing_adni_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_ventricles", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_adni_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 8, "selection": "discovery_only"}}, "contract_sha256": "1f7403bea6b8ee84339b904397d723ba6d575b1278b30c9023046e6b9e3a8d3e", "dataset_id": "neg_p_fishing_adni_s2", "discovery_cohort": "neg_p_fishing_adni_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_adni_s2_DISC": "95173649d61e219a2b3a69d8e9cb078ad4d8aa95192f9d22307c316b660d9fd8", "neg_p_fishing_adni_s2_REP": "ce2841d471ecec2155a4c71fa16d910c9e5f3032bac99276c9dc1aa246052c28"}, "partition_paths": ["neg_p_fishing_adni_s2_DISC", "neg_p_fishing_adni_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_adni_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a0b6662525d63d8bbc3bd56bb04fab0b8e8cfd3602f0daee079a4bdbad28eb5a", "task_id": "ncb21-task-13855d1780cbb1e3"}
{"benchmark_case_id": "ncb-synthetic-stress-314c6524cbe93809", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_hcp_aging_s1", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_hcp_aging_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SalVentAttn_z_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_hcp_aging_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "314c6524cbe93809d7373910bd99ce634a5e4b4a45df3fea8f96ee6cb99675ca", "dataset_id": "neg_underpowered_hcp_aging_s1", "discovery_cohort": "neg_underpowered_hcp_aging_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_hcp_aging_s1_DISC": "f6f439718e544d8d9153f7c47e66a50c45fa31fd04d6e5dcdfd4096a2b151e54", "neg_underpowered_hcp_aging_s1_REP": "8324be50f66633403de0a258497b199c341165bae0a4bbb1608dec3b0eaa1e1a"}, "partition_paths": ["neg_underpowered_hcp_aging_s1_DISC", "neg_underpowered_hcp_aging_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_hcp_aging_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c6d558b5b0298ae7ea74fcc2c747b6d7cd81821e27b4eee429be708e7b1aa554", "task_id": "ncb21-task-144a123ce2d6a385"}
{"benchmark_case_id": "ncb-synthetic-stress-820e065fb07facd4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_hcp_aging_s3", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_hcp_aging_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_hcp_aging_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "820e065fb07facd4789af32a4802abc881f21f40328afe0d43c2bf134be15b9b", "dataset_id": "neg_underpowered_hcp_aging_s3", "discovery_cohort": "neg_underpowered_hcp_aging_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_hcp_aging_s3_DISC": "f43e276ba42f7dff2c8713dbdf843a192b55e2c97020fcd24958036f597a988b", "neg_underpowered_hcp_aging_s3_REP": "d24683c281385cb6878630a7a9eb205af7ad9a057700f77dd6aa0d87be1fee6f"}, "partition_paths": ["neg_underpowered_hcp_aging_s3_DISC", "neg_underpowered_hcp_aging_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_hcp_aging_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "eeca5f5a4a28b8dacb4fc47f3b73b31508c4b5b4be0a455b5f1f02b4116edc46", "task_id": "ncb21-task-1755203de8c8e6a0"}
{"benchmark_case_id": "ncb-synthetic-stress-48888b0a50e6c685", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_ukb_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_ukb_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Default", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_ukb_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "48888b0a50e6c685490abed171088fc4a4973989ddd34fd27cd02c8079e7be19", "dataset_id": "neg_random_label_ukb_s3", "discovery_cohort": "neg_random_label_ukb_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_ukb_s3_DISC": "895e33f623122967b1a4988229703b5d667405c4f38fc217b72919a0e68b46ba", "neg_random_label_ukb_s3_REP": "e32e883672ad7047d58a024650f96ae4b821619b9bbc20b733269a19f2500f3f"}, "partition_paths": ["neg_random_label_ukb_s3_DISC", "neg_random_label_ukb_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_ukb_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7e24f5f91a89407c81c9fe0bf934cddf0127b641057609d088b9b4bdffdac86d", "task_id": "ncb21-task-181bc46e4453c91f"}
{"benchmark_case_id": "ncb-scientific-815d879b9076393c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_fc_mean_abs_abide1_site_split", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ASD case-control mean absolute FC ABIDE1 real site split in fMRI-FC, using ABIDE1_DISC_sites as discovery and ABIDE1_REP_sites as replication, test the claim with expected direction two_sided and adjust for age;sex when available.", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "815d879b9076393c67c02ef257b22635e8409b74da079f46cc05a619c8020db7", "dataset_id": "ABIDE1", "discovery_cohort": "ABIDE1_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE1_DISC": "5a174cbcac2a070ea3f3af8be549a18c404215aaa031137242335f4c83643da4", "ABIDE1_REP": "d0a670f11f1c39a32e1e182cd1457b51acbec5518845795c26872642565c9f35"}, "partition_paths": ["ABIDE1_DISC", "ABIDE1_REP"], "question_sha256": "caeaf78486a60e9fc6c74a92eb0070452d426a81bc5f8582de22e325342ebded", "replication_cohorts": ["ABIDE1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "2e4fc3f1a566454a86934ca188b1e09881161f3d8dc9051d556750ba3aef55ea", "task_id": "ncb21-task-185c5e67f296f418"}
{"benchmark_case_id": "ncb-scientific-5af5c999c214ab93", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q036", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Vis_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered within-Visual connectivity (fc_fc_Vis_Vis_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5af5c999c214ab9372f9f2d8ade3dd6da56394efb2231c76129e7a21833959ea", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "ccf4099ad8b6609ff96a20fdbbcbff59e776a091fb1a0aa0cfb687df1d3bfa79", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "70d5fa4400acc285f2f676ef2e4b905e33e62f4ed6023ddd94c0032901dd746a", "task_id": "ncb21-task-1a1dd6d309bd7a8a"}
{"benchmark_case_id": "ncb-synthetic-stress-545812ed0777dcb3", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_hcp_aging_s2", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_hcp_aging_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_hcp_aging_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "545812ed0777dcb326c0c070e7e09f5552f180191f59a1883d0220c9b13ba806", "dataset_id": "neg_underpowered_hcp_aging_s2", "discovery_cohort": "neg_underpowered_hcp_aging_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_hcp_aging_s2_DISC": "59424a442b03d2946941f07f8be7bd39057cde5548d102d7a619795e14856c82", "neg_underpowered_hcp_aging_s2_REP": "2199eabbe0fcb0e247f995ce314f08fa9c2a116de94fb356730f0eba4d6f997b"}, "partition_paths": ["neg_underpowered_hcp_aging_s2_DISC", "neg_underpowered_hcp_aging_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_hcp_aging_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "dd284ed7f0e662b028fb2ba299cc31f7867a23dd7d9369ebdecc45dd6f1a99ea", "task_id": "ncb21-task-1a8cf91bedabfc69"}
{"benchmark_case_id": "ncb-scientific-c9246d08669f6265", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_031", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher age associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for sex and cognition?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c9246d08669f6265e26d6a274208eaff54a2c585d734065f5cd7d4289f86a6ed", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "98180d740463670610765b132da60a10ace8a9493947889b4dd690caf805ac31", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "556803894ff3fc4e4c1913687e5b1e57f356f27549f7ac2b37c4250be981bdae", "task_id": "ncb21-task-1a9d9bff2f919e15"}
{"benchmark_case_id": "ncb-synthetic-stress-564b9d40a50edcaa", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_abide2_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_abide2_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_abide2_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "564b9d40a50edcaa8142ab6493c71f4b80ab6e567ad2535fe8a98bdb93db45c3", "dataset_id": "neg_random_label_abide2_s1", "discovery_cohort": "neg_random_label_abide2_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_abide2_s1_DISC": "79fe3def55e062135660cfbe96f64d4ba01a268c9c785beae1409daa2c839e1b", "neg_random_label_abide2_s1_REP": "1a48bd31073a47bf20ed7c11bca1b3bd32514920b46a943a964c9784b340b62c"}, "partition_paths": ["neg_random_label_abide2_s1_DISC", "neg_random_label_abide2_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_abide2_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "acaa41dbd9d94bd4b855f408c90b414211cebffc4cadc39c0c4b5ed5ad7cbcf0", "task_id": "ncb21-task-1ba1546c05929dba"}
{"benchmark_case_id": "ncb-synthetic-stress-5ca3b178253860d3", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_adni_s3", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "neg_site_confound_adni_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_hippocampus", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_adni_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5ca3b178253860d3de7bb4c56d54046c72aded3862e8090e3d6922fd311ea25a", "dataset_id": "neg_site_confound_adni_s3", "discovery_cohort": "neg_site_confound_adni_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_adni_s3_DISC": "08e8cbc0ff62054669e60a6fb5b1e7741ecfd6c0856b83e2a3e90c27f5a16389", "neg_site_confound_adni_s3_REP": "5a3c7e426601953bbe6d6e8082697896713343065ff7224f2908da2bee04eefe"}, "partition_paths": ["neg_site_confound_adni_s3_DISC", "neg_site_confound_adni_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_adni_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ec29d8cdc7efb0257ea62910388c3e220a16350a576ad3f474fedb559f922f06", "task_id": "ncb21-task-1c2a6e57a29020f9"}
{"benchmark_case_id": "ncb-scientific-1f9b7b9991250bd7", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "fbirn_sz_cognition", "covariates": ["age", "sex", "site"], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": "summary_fc", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For schizophrenia cognition anchor in psychosis, using FBIRN as discovery and COBRE/SZ_JH as replication, test the claim with expected direction two_sided and adjust for age;sex when available.", "replication_cohorts": ["COBRE_REP", "JH_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "preregistered"}}, "contract_sha256": "1f9b7b9991250bd79fc9033f2a5b7c572c78ef720a49515d03a284e3899b70d3", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "FBIRN_DISC": "5a9a103412824c97ff34a4b7c9107198e9309be14f345c917761eb11adcdbd82", "JH_REP": "f40fac0acd9aa1425552a409658e883651432d578db1db8a9c290e2ea4850ae6"}, "partition_paths": ["COBRE_REP", "FBIRN_DISC", "JH_REP"], "question_sha256": "9daf31b295166f85b24a8dd69d534c7b295991f845021cb2a8b9bc20394544fa", "replication_cohorts": ["COBRE_REP", "JH_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "aa700b11ddda8dc831c0f750e917ea5144072f1c6043e2662d40dc08e051eb42", "task_id": "ncb21-task-1cd56ef2b757f69d"}
{"benchmark_case_id": "ncb-external-transfer-5794ca4d9a4f492b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_bd_amygdala", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "BIPOLAR", "control": "CONTROL", "var": "dx"}, "outcome": "smri_amygdala", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_amygdala negative for BIPOLAR compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5794ca4d9a4f492b604df75e21a70452f997e1068093f33ff92a5cd7c5105b7f", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "29d4a397de717b443ff164f79535880a17ca14137a5ea81c5b218276f867b10f", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b6f67e070870d5a4b54a74765ba8de029195f1cfe24e0fa8140deb5fa3d9300b", "task_id": "ncb21-task-1ddc3ef41e4ad468"}
{"benchmark_case_id": "ncb-scientific-81e24d3b130902a4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q045", "covariates": [], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across FBIRN_DISC and FBIRN_REP, is the SZ-versus-HC contrast for fc_mean_positive directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "81e24d3b130902a46cd52114a0894c5d3052a400c072cda182917e5eb6728851", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"FBIRN_DISC": "5a9a103412824c97ff34a4b7c9107198e9309be14f345c917761eb11adcdbd82", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a"}, "partition_paths": ["FBIRN_DISC", "FBIRN_REP"], "question_sha256": "0a245ad296efb92fea22803694ef8dbf1032ab3add438e00ed100399d1c39f51", "replication_cohorts": ["FBIRN_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fe7ca606cc15152226741e3c17bc7df83318a04ec3ecb53c6b3c26fc091a2ad7", "task_id": "ncb21-task-1df9ebb9fd1e2432"}
{"benchmark_case_id": "ncb-scientific-cff1d7d2ccfb4083", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q017", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Salience/VentralAttention-Somatomotor connectivity (fc_fc_SalVentAttn_SomMot_z), with no additional covariates, and does this replicate in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cff1d7d2ccfb4083777868ad19918ae7945541ba0eac4f51f5d045cb634efc6b", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "709e9febbf7abd25df4363a4d1182f95a9e3a8fa6210b3dcb398f946fc7bbe9f", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5df824301ab1addd97daaf4023192f0090f63d68208b8c74686e168f40a67e43", "task_id": "ncb21-task-1ee6ff3275d5a6b2"}
{"benchmark_case_id": "ncb-scientific-41e14c6dd1c2213b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q049", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ABCD_DISC and ADHD200_DISC, using each cohort's available ADHD-control coding separately (ABCD dx=1.0 vs 0.0 excluding missing dx; ADHD200 dx in {1,2,3} vs 0), is the ADHD association with Salience/VentralAttention-Somatomotor connectivity (fc_fc_SalVentAttn_SomMot_z) in the same direction, with no additional covariates?", "replication_cohorts": ["ADHD200_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "41e14c6dd1c2213b09c65b85fb99ab48160786245ae19fcdf1dbe6c8a7704fe3", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd"}, "partition_paths": ["ABCD_DISC", "ADHD200_DISC"], "question_sha256": "23a368ff60828e0ee0db8a67512b99e21274ca785f78e54e5a323fc5016e3be0", "replication_cohorts": ["ADHD200_DISC"], "schema_version": "2.1.0", "scientific_core_sha256": "c4867377c24ee0fa3f3e85e6d399d03d4d0faac735bd27d424027901e88f1984", "task_id": "ncb21-task-1fa31ad921dc7522"}
{"benchmark_case_id": "ncb-scientific-e655e7f3059cc2a2", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q002", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with higher Default-Salience/VentralAttention connectivity (fc_fc_Default_SalVentAttn_z), with no additional covariates, and is this replicated in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e655e7f3059cc2a2fa0bfd47f5738215071ffd1c322d56face875667b06330b8", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "ca9d65dbe55f436643649c8b8bcfd65890cffe115c655917bc60e7333a44fd48", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "158fa35591c0432d6f39d69fb2b847f7bbbbebe5dfc9c30f7b1e3824d1070c28", "task_id": "ncb21-task-20579a56de42c261"}
{"benchmark_case_id": "ncb-external-transfer-79370db65226ca4e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_inferiortemporal_random_label_s20260726", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_inferiortemporal", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_ad_inferiortemporal.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1cd72258063ae306c874c4f2a900ff8d720999ae59b6f4edf132663ef97afab0", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "8831f9ba44285c11043c59f5d492330ace159e3f203f1bba7562e89ef6098e37", "selected_assignment_rows_sha256": "a0b1e50cbe0672adc8f065ecc34b77d5381e356b25069e040db24adbf6b73b67"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "a0b1e50cbe0672adc8f065ecc34b77d5381e356b25069e040db24adbf6b73b67", "discovery_seed": 20260726, "group_column": "ncb_random_group", "parent_external_claim_id": "ad_inferiortemporal", "replication_seed": 21260726, "seed": 20260726, "selected_assignment_rows_sha256": "a0b1e50cbe0672adc8f065ecc34b77d5381e356b25069e040db24adbf6b73b67", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "68648c24e14bfea390f99d3cd81afe3c17d560e19560ee93efbe636e11f4487f", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d28010e97834411601ae97a3145463ac1ebf45f565ff34d3cf16a878f0dba05c", "task_id": "ncb21-task-2169084a38eb251b"}
{"benchmark_case_id": "ncb-scientific-ccf76ee04722df94", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q007", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC, excluding missing dx, do ADHD cases (dx=1.0) differ from controls (dx=0.0) in within-DorsalAttention connectivity (fc_fc_DorsAttn_DorsAttn_z), with no additional covariates, and is the difference replicated in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ccf76ee04722df945c7c574a27b2da49fc63bef96e9b9b9f3ee1612f4beb0257", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "d87f3407ef1037002f2040f38a585d777582f88c865231dae7f9968130e7640e", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1d9d47d8fb3306553ad618d72cc1edd153c18a615ede16497517080992ffebab", "task_id": "ncb21-task-217080e5d5d61690"}
{"benchmark_case_id": "ncb-scientific-319a1462bfdbc89d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_047", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "cohort in [\"HCP_DISC\", \"HCP_REP\"] or dx == \"0.0\"", "question": "Across ABCD_DISC and HCP_DISC, with replication in ABCD_REP and HCP_REP, is higher cognition associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and sex within each cohort and restricting ABCD to dx=0.0?", "replication_cohorts": ["HCP_DISC", "ABCD_REP", "HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "319a1462bfdbc89d930616a30480c076432748e170281465818679f30546de86", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c", "HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["ABCD_DISC", "ABCD_REP", "HCP_DISC", "HCP_REP"], "question_sha256": "6abc295941872d2b94bfd03c628b05449f0924fa3be230913bdcc5b77088a917", "replication_cohorts": ["HCP_DISC", "ABCD_REP", "HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5d791c868d0cb67c9971edee8b781f2cc7cd5796fe24a176782456f0da5a1ba7", "task_id": "ncb21-task-22401568a4a4fe75"}
{"benchmark_case_id": "ncb-scientific-2e389c7806389508", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q023", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2e389c780638950829799320349d8009aea6c3e9e69be08b1982e12b5b434c52", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "fefefcfb47a19cddc7e1c8d9a505edb76498995c8d7234c8be0d2612f7f85b96", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f09200a182fcbc452b9265fe395f6be18cfd9cb6c3b6ec7a566a33fd78f4e050", "task_id": "ncb21-task-2256c13eb330feb3"}
{"benchmark_case_id": "ncb-scientific-83e8c22eb0f4831a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q028", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "83e8c22eb0f4831ab466f92d33a57545f9a4ac8eb8d3c9af44021b75c7fef4c4", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "0bc71a22cf8f7ec2bcf4ebf922aae80b71cd6a4ff053429780628fbac2d1d82b", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "93ccb767b027dfaa402523d74235849cb5cf06b144260572cb441747719f7ceb", "task_id": "ncb21-task-22b6347de5b895fd"}
{"benchmark_case_id": "ncb-external-transfer-e60c97d7572df957", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_adhd_thalamus", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "ADHD", "control": "CONTROL", "var": "dx"}, "outcome": "smri_thalamus", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_thalamus two_sided for ADHD compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e60c97d7572df957cdf5dfebc4c3e37ea79df71ebd98929bb7f3c510c02f2301", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "9d0600146d2fb15941738d4f7a3c900294425ae8438d68fe435554faecd45ebd", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "04cd5ec4ac05d5b46394d035f1ac8815d6d80036cd8f90df3113b57d08e47b6b", "task_id": "ncb21-task-2334fd77d5672850"}
{"benchmark_case_id": "ncb-synthetic-stress-c93f76e6f75aeaeb", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_hcp_aging_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_hcp_aging_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_SomMot_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_hcp_aging_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "c93f76e6f75aeaeb95c07c7edeae734e0769baa6b0a1b0ba0ad6f28c6730c1d9", "dataset_id": "neg_p_fishing_hcp_aging_s3", "discovery_cohort": "neg_p_fishing_hcp_aging_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_hcp_aging_s3_DISC": "cec5938bcbbb3612ae45d9e77f630929f7a72aba65854646efcdbe58dcfe0622", "neg_p_fishing_hcp_aging_s3_REP": "df01aacfd1aecf9d651dfee49216e0b627520e717a263f38f0200c52bebb2457"}, "partition_paths": ["neg_p_fishing_hcp_aging_s3_DISC", "neg_p_fishing_hcp_aging_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_hcp_aging_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "8cb3f1a61d243e802dc1ff7c9f75545df46b992f653525c414be89a9235328be", "task_id": "ncb21-task-2337108f0ac6ee78"}
{"benchmark_case_id": "ncb-scientific-c631e745a39a4c34", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q038", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Vis_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Vis_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c631e745a39a4c34b7a2b47ee20ac723363fb4d3f247ba63938ada9c0511f640", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "fafd5037b8601c23c53be1427181a301e0c7cb55c0ce7ed82f6c3f9c922fedde", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d58de6cb3567b771970ef7e1781d5993de3bfdc0c51b47480687006ae9781bf5", "task_id": "ncb21-task-2378bd6a4aa6d917"}
{"benchmark_case_id": "ncb-synthetic-stress-f034e20c6a6bc7f8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_abcd_s1", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_abcd_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_abcd_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f034e20c6a6bc7f8897f01e8c3b3c9f1448e9e6fbcd0b88c8040e4f2acd22953", "dataset_id": "neg_site_confound_abcd_s1", "discovery_cohort": "neg_site_confound_abcd_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_abcd_s1_DISC": "7e54a4fe05390e6a67ff5d75114b3b255da025cb64bfdf174ac20f7eb7dc1f73", "neg_site_confound_abcd_s1_REP": "3b45e602771b0c7d6c705f7b7eddf6cee1100e6a207120d45916656c9b81ceb6"}, "partition_paths": ["neg_site_confound_abcd_s1_DISC", "neg_site_confound_abcd_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_abcd_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "cf9472bc97bbe28ceb51320d6c79715b85d28f0a3fe6294a81e59d4842858fbb", "task_id": "ncb21-task-23affa12649e5e2a"}
{"benchmark_case_id": "ncb-synthetic-stress-59ef3adedd2d2f5d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_adni_fmri_s2", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_adni_fmri_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_adni_fmri_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "59ef3adedd2d2f5ddb1dc05e545dcd4028ddf04f675c32b44f3645bdb7d96646", "dataset_id": "neg_site_confound_adni_fmri_s2", "discovery_cohort": "neg_site_confound_adni_fmri_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_adni_fmri_s2_DISC": "3ca9a3a348f1e7b8bdc2f77eca71145d2e34eba0ae9c4d91ca5b5bd0508d7d6a", "neg_site_confound_adni_fmri_s2_REP": "b5f8a4e434662b43739b06057df8d1df5c8bf64856adaebbb4f7fe204de807db"}, "partition_paths": ["neg_site_confound_adni_fmri_s2_DISC", "neg_site_confound_adni_fmri_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_adni_fmri_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "73720917c980c11e5a5373b4d9cd405126b81788580f2cf3f7718030573964e4", "task_id": "ncb21-task-23b9c13946d2b21b"}
{"benchmark_case_id": "ncb-scientific-42b2c11ed186c2c9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_006", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Vis_Vis_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower visual-network within-network connectivity (fc_fc_Vis_Vis_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "42b2c11ed186c2c9d794dfd42e14b54cf31afc8d70f2f8c136913760977724fb", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3", "UKB_REP": "6da6a67cb610290a28f97b077dd2aa0e82c39161e4b3c622857cb54843df2357"}, "partition_paths": ["UKB_DISC", "UKB_REP"], "question_sha256": "00fd057640d4e21c3977da61b48d58c502b5a2a71d27ad9a44b09795174e6371", "replication_cohorts": ["UKB_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "15bc296126f81e5125c49daafa677a68730aed5eb7ee8ac4a807083d818e2788", "task_id": "ncb21-task-24a9f287d05f4f0c"}
{"benchmark_case_id": "ncb-scientific-4d6ed37bb9324c72", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q045", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADNI_fMRI_REP", "estimand": {"direction": "negative", "group": {"case": "2.0", "control": "0.0", "var": "dx"}, "outcome": "fc_fc_Default_Default_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx in [\"0.0\", \"1.0\", \"2.0\"]", "question": "In ADNI_fMRI_REP, excluding participants with missing diagnosis code, is diagnosis code 2.0 associated with lower fc_fc_Default_Default_z than diagnosis code 0.0, adjusting for age and sex?", "replication_cohorts": [], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "4d6ed37bb9324c72153b3fa839362f89320d16c7cbd9dd2659db729eb80061bf", "dataset_id": "ADNI_fMRI", "discovery_cohort": "ADNI_fMRI_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_fMRI_REP": "77b228db80400e42457cdc1a715f338fa645e8901922ef5f6f7c7f7d3d176c13"}, "partition_paths": ["ADNI_fMRI_REP"], "question_sha256": "ef2a8e15be082d933317e939029fdcff5bd018f83edc5aeceae2519cad111e55", "replication_cohorts": [], "schema_version": "2.1.0", "scientific_core_sha256": "96a891634aee34db98fbb9b09bacad84f945bcf1161c384f8d983a8e93aed009", "task_id": "ncb21-task-2596cecf69169eae"}
{"benchmark_case_id": "ncb-synthetic-stress-7446a0a12b859ed8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_gsp_s2", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_p_fishing_gsp_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_hippocampus_rh", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_gsp_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "discovery_only"}}, "contract_sha256": "7446a0a12b859ed8e53c7b110afe77fb0d93ec9abe2002eaa3710768bc3cf1fc", "dataset_id": "neg_p_fishing_gsp_s2", "discovery_cohort": "neg_p_fishing_gsp_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_gsp_s2_DISC": "8bea041f1c0edf200aa85fc5341de7e17c430c0f56c2cd277171ad9c2185a494", "neg_p_fishing_gsp_s2_REP": "6db208057d28abac954faa6f6e9a7b4c999767c351d139b26fb65a2a8b3229fa"}, "partition_paths": ["neg_p_fishing_gsp_s2_DISC", "neg_p_fishing_gsp_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_gsp_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "93d74ad711a74806b6e2c46a98a2dad36f3ae2cd8db0d42fcaafa4412077b04d", "task_id": "ncb21-task-26be4e6c0bc4f9f1"}
{"benchmark_case_id": "ncb-scientific-08efd1786e5b448a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q012", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Default", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Default differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "08efd1786e5b448a84158f5fd3ce228ce6c198e48d98d9822b46850721e8ef2c", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "9763df7a7dd31b105295896e054169d61cc3598bb9a9102307e7c70996ef8888", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d647909b7af62caf138f5594de84a4dba7b5f392ecab6a80397767ee36322c30", "task_id": "ncb21-task-26de2f66465b717e"}
{"benchmark_case_id": "ncb-scientific-a427d5471566b2cf", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_027", "covariates": ["age", "sex", "site"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, is higher cognition associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and sex?", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a427d5471566b2cf475103489cde2f05ea57bbab09ea9cdd585ccf3a09b6dc00", "dataset_id": "HCP_Aging", "discovery_cohort": "HCP_Aging_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_Aging_DISC": "47082908a7b0b17d0b8a006028dff9d08a56af3f8c6e8d08627ca3818f85a4fd", "HCP_Aging_REP": "e4682154e236a020f91b7932fe75341cf7a0eed865089e5172cad83a6989e965"}, "partition_paths": ["HCP_Aging_DISC", "HCP_Aging_REP"], "question_sha256": "a41420f536f7714287e4dfce224f39ed0adc6ad4ae0bd1571069678cda9ee1ba", "replication_cohorts": ["HCP_Aging_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "9909e5d6fa1fb30b43617472f134386b76565f1092f7b928b667f8782abe8313", "task_id": "ncb21-task-28a263d013fa1b7a"}
{"benchmark_case_id": "ncb-synthetic-stress-0f0403a272133ad1", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_abcd_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_abcd_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_abcd_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0f0403a272133ad1e9738dc220a9a2dd1d5d73ef9331e00516f1d9fde01d31f9", "dataset_id": "neg_random_label_abcd_s1", "discovery_cohort": "neg_random_label_abcd_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_abcd_s1_DISC": "67df63d0961137d6fa3c845534ef40f2aa09c47e4537c26dbdd5c09906f31a87", "neg_random_label_abcd_s1_REP": "73ef8112ab82e3597d9df25c0762a1a989f63105b1a94842a97d4bbe43febc25"}, "partition_paths": ["neg_random_label_abcd_s1_DISC", "neg_random_label_abcd_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_abcd_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "cf707553553e6d25cdb0c2c52e39fe67c7eb650be7f6773b68d942695c54c49c", "task_id": "ncb21-task-295a18752281c742"}
{"benchmark_case_id": "ncb-scientific-0bccd4e0b2409e23", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q021", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "1", "control": "0", "var": "dx"}, "outcome": "fc_fc_Cont_Default_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, among diagnostic categories, does ADHD-combined type (dx=1) differ from controls (dx=0) in Control-Default connectivity (fc_fc_Cont_Default_z), with no additional covariates, and is the same contrast evaluable in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "89eeb82766aa49d0eae879688b4dcfa871807b5faa70ce3bb14f16084b4beb4c", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "e29b95fbe57d2d0bc975e13e732b5659c268a8998d0f486786a226e7fff9c820", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "70f8501e93817b3ed1124b91c60d8b11a9e7a7755259d4c0663145e87f037a44", "task_id": "ncb21-task-29da26499534583a"}
{"benchmark_case_id": "ncb-scientific-424e2babe414b942", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_037", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher cognition associated with lower default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for age and sex?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "424e2babe414b942c9de6cea445152da63bc02ae3d4a57cba78750f02b7f0960", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "c4847cc9ba269eec2b09c8947c21b8ce2ed072cb78d3d482e5b2b258471e8692", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "320bceb7128a61025172835c2cec6a45abce4da6d7bfb313cc492aa8fb944e6f", "task_id": "ncb21-task-29ede93d8ab1d56d"}
{"benchmark_case_id": "ncb-scientific-f84fe6980294c120", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_021", "covariates": ["age", "sex", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_Cont_Default_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, is higher cognition associated with altered connectivity between default-mode and control networks (fc_fc_Cont_Default_z), adjusting for age and sex?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f84fe6980294c120bccc3de4d0ceb634edd5c41e1166cc53760b2275e4bae482", "dataset_id": "HCP", "discovery_cohort": "HCP_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["HCP_DISC", "HCP_REP"], "question_sha256": "96aee9e4045df0936dc512090197b1714506d8f70e189d6949dfa3665e906cc9", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d3f54a93a9fe0f4de197f479c2784ef3b1da89ac5afb83c2eb70ee9ab7a8016f", "task_id": "ncb21-task-29f2629513c4d93d"}
{"benchmark_case_id": "ncb-synthetic-stress-92eebea972c19814", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_oasis3_s3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_p_fishing_oasis3_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_midtemp", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_oasis3_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 6, "selection": "discovery_only"}}, "contract_sha256": "92eebea972c198140ff097155fdf333c00a5b3faef139a03d1632c11422600e9", "dataset_id": "neg_p_fishing_oasis3_s3", "discovery_cohort": "neg_p_fishing_oasis3_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_oasis3_s3_DISC": "90ea10d5aa92fac4884a575da5a569c6ebdd41e3a40d4c5f70776b071fe51344", "neg_p_fishing_oasis3_s3_REP": "2dafbe3c9e9a1719c7f539e1cf145c609c48d040064003fd8c24c770845d08df"}, "partition_paths": ["neg_p_fishing_oasis3_s3_DISC", "neg_p_fishing_oasis3_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_oasis3_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6f81a4e8c24145b23bec1e8f19f033146f705a5abe6d8feaa88a77bdc865b5b1", "task_id": "ncb21-task-2a069a4f9d553bee"}
{"benchmark_case_id": "ncb-scientific-81d14342bc5a3c18", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_32726311_pmid32726311_dg_aging", "covariates": ["sex", "eTIV"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_hippocampus", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "For literature-grounded Older age among cognitively normal adults effect on Dentate gyrus age-related MRI vulnerability / hippocampal integrity in combined functional-structural MRI in the primary study; structural MRI in secondary analyses, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "81d14342bc5a3c187ebbc5c08c3f60f065445493303b049bc443caa0bb16a644", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "cf818ca98b34d5da6bf8f0f849b706221eb0170af6427e2f5d2117d60937c6e9", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "48fe341ebfe1749a66fa45d30b851fb60d4cfa44272f1de27e7ba3c8f0c6d8cc", "task_id": "ncb21-task-2a0c89906d3bf1f2"}
{"benchmark_case_id": "ncb-scientific-548d362dc2682286", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q034", "covariates": [], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across BSNIP2_DISC and BSNIP2_REP, is the SZ-versus-HC contrast for fc_mean_abs directionally consistent in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "548d362dc26822867e373f356852faa0ed9fa00f1757c8e4486a1d240506e03e", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23"}, "partition_paths": ["BSNIP2_DISC", "BSNIP2_REP"], "question_sha256": "e8f14d2146dd256528b401a0503ab26337c62569d3a5d1214721c22ad58877f2", "replication_cohorts": ["BSNIP2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "537fa3ff613c87fe50799027634a4d4d674f303fc32f98016cd680303c050351", "task_id": "ncb21-task-2a683ce1e6dce377"}
{"benchmark_case_id": "ncb-scientific-bc6d05b49560e9df", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_018", "covariates": ["age", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_SalVentAttn_SalVentAttn_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, do females and males differ in salience/ventral-attention within-network connectivity (fc_fc_SalVentAttn_SalVentAttn_z), adjusting for age and cognition?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bc6d05b49560e9df556c27a32ce7b1ba5f9f2ef45e09a11867a8804906ed9dcf", "dataset_id": "HCP", "discovery_cohort": "HCP_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["HCP_DISC", "HCP_REP"], "question_sha256": "dee65f72a47aff4d0e1ccbb29ba0c69bb7893bc2d8fbf51e2549b1c4bcdcbaa5", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b004c255aa05390f098fb8b1cf40293d5b8f8a7644484f581710a21cd45094bf", "task_id": "ncb21-task-2a7a3de6b7d503b4"}
{"benchmark_case_id": "ncb-scientific-3e1160c83f5950a6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q001", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_DISC, with replication assessed in ABIDE1_REP, is fc_mean_abs lower in ASD than HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3e1160c83f5950a67cb5f0bbc0478fdf9f1049f9a00563f8ba1bc631c90a9dbf", "dataset_id": "ABIDE1", "discovery_cohort": "ABIDE1_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE1_DISC": "5a174cbcac2a070ea3f3af8be549a18c404215aaa031137242335f4c83643da4", "ABIDE1_REP": "d0a670f11f1c39a32e1e182cd1457b51acbec5518845795c26872642565c9f35"}, "partition_paths": ["ABIDE1_DISC", "ABIDE1_REP"], "question_sha256": "0a75415b4c04408e34290566724e63c7ba3987886fd331f3408c5bf65eb33b4c", "replication_cohorts": ["ABIDE1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "9469521d14c3659d1013228401e75bf62c0d991f15ab65567cfcfde3211aeaee", "task_id": "ncb21-task-2aa14ad4c6a4579e"}
{"benchmark_case_id": "ncb-synthetic-stress-0cd265e25bb8f4a6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_adni_fmri_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_adni_fmri_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Limbic_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_adni_fmri_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "0cd265e25bb8f4a611ccea7c88317f72040f9c7850dc7646c615fa9d13a7ba23", "dataset_id": "neg_p_fishing_adni_fmri_s1", "discovery_cohort": "neg_p_fishing_adni_fmri_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_adni_fmri_s1_DISC": "d2b2566fcb2e9a45759c17510120f6a2ef7f5cfff3ecc69cf85b4f9db090346d", "neg_p_fishing_adni_fmri_s1_REP": "bcfab53d43278da34acbec043e05a0479f71374543f7e0a3ad9c88e9990f0289"}, "partition_paths": ["neg_p_fishing_adni_fmri_s1_DISC", "neg_p_fishing_adni_fmri_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_adni_fmri_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "923edb3343da076787e3b6fb5e50d8cd04875d463da3f3ada42662db9daca116", "task_id": "ncb21-task-2acff5dcd8c32ef2"}
{"benchmark_case_id": "ncb-scientific-c671d3de1b2734cb", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_29653095_29653095-psychosis-fc-01", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": "large_scale_resting_state_network_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded Psychosis probands versus healthy controls effect on large-scale resting-state network connectivity in fMRI-FC, using BSNIP2 as discovery and COBRE as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c671d3de1b2734cb8e64ccc55fdd15ea4118e551d604845c6f756f7b71f7ba43", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc"}, "partition_paths": ["BSNIP2_DISC", "COBRE_REP"], "question_sha256": "54acffd20c41e9a0c533f35de4add5b79743714fedc400c8ca10b2f70357ed1f", "replication_cohorts": ["COBRE_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "43b855c64b7c2cc5f63a22df184254771d788f101b301cfd61e9e920bdaa187a", "task_id": "ncb21-task-2af7eda20deedfc3"}
{"benchmark_case_id": "ncb-external-transfer-41a540435c5c78bc", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_adhd_pallidum_random_label_s20260760", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_pallidum", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_cnp_adhd_pallidum.", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "66984b6d6f418fec08df7648cc0d69fce52b12d7602e9ca795bd2a11c20fa3e8", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "2277f30ed2e1395a1fd53b67ac1e9946eafc359a6d8227d1ce3d7afb7863ba54", "selected_assignment_rows_sha256": "5dc0bb00a341357fafe66977f2b57923fbfec68bfe0cd85748db45d2db6f3ef8"}, "generator_spec": {"assignment_count": 265, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "5dc0bb00a341357fafe66977f2b57923fbfec68bfe0cd85748db45d2db6f3ef8", "discovery_seed": 20260760, "group_column": "ncb_random_group", "parent_external_claim_id": "ADHD_pallidum", "replication_seed": 21260760, "seed": 20260760, "selected_assignment_rows_sha256": "5dc0bb00a341357fafe66977f2b57923fbfec68bfe0cd85748db45d2db6f3ef8", "type": "independent_random_group_labels"}, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "2ea86ad7653b51850f171ad22fdf0fa4309290176b97d4d2ce94d089df7bb512", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c155b6df0d949bb8331dcf0c2db8a69bfc13ccbdbb45540961320578d17ce519", "task_id": "ncb21-task-2b86bc8446233255"}
{"benchmark_case_id": "ncb-external-transfer-7f37d5578b3cc678", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_mci_precentral", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "MCI", "control": "CN", "var": "dx"}, "outcome": "smri_precentral", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_precentral negative for MCI compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7f37d5578b3cc678c580754daec1b63b7cd7488813df0e26efb5b34b92a2a8f6", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "09d14d1b9ac5fdbe48ab201317aab5b736988dc40d6ff0e862ca838bb466865f", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "9024534c7a37783fe23018ecd8e4007537a72766df2c02473394b77d6f2bd832", "task_id": "ncb21-task-2c6cacba778204de"}
{"benchmark_case_id": "ncb-synthetic-stress-45e4a4f6e1fc74d9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_hcp_aging_s1", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_hcp_aging_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_hcp_aging_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "45e4a4f6e1fc74d9c2c04a83e9acf85c097c7b90ff20accdd760f6bb26e1e4c0", "dataset_id": "neg_site_confound_hcp_aging_s1", "discovery_cohort": "neg_site_confound_hcp_aging_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_hcp_aging_s1_DISC": "89ac825e0ccfe033b6a6f5fefbdb71292479c3e651d6d6467959f51f4fd429c7", "neg_site_confound_hcp_aging_s1_REP": "39e45feda68b9c351de92fd2128a3a887848f0784c7038f26bd9c1a0b61dfa45"}, "partition_paths": ["neg_site_confound_hcp_aging_s1_DISC", "neg_site_confound_hcp_aging_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_hcp_aging_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b0b1ea5fcf11101384bf11809607ced99e48bd131fd7adb9d702f15c57addf04", "task_id": "ncb21-task-2cb3010c86628713"}
{"benchmark_case_id": "ncb-scientific-9c2e4221cf5ca105", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q018", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Default", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Default differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9c2e4221cf5ca105c142aa03f1212934ddcc6f3a0b4ae66e5f9d130f892c1d68", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "ba928d407d1ca0f6c5afdaca542afb27bbb701df9518fa5bf8c117ed20911a6c", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "dc88b2e97bfd7ea2c0e87dbaf08c4f744bb24139ffef65d17071bf4fc4de52c2", "task_id": "ncb21-task-2ce25bc332b80d88"}
{"benchmark_case_id": "ncb-scientific-bdc24737aa23b682", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q009", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered Limbic-Salience/VentralAttention connectivity (fc_fc_Limbic_SalVentAttn_z), with no additional covariates, and does the association replicate in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bdc24737aa23b68213ee1a77d82e33597f5039ce548624b69e5675e7b1b02b18", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "19f7933999dbf034aab1cba658fd2ba657b5373ecc87b7b0805823638f64981a", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b4d5415534cce368be98149cf72e0a4b63cabf56605c95d53afa73d2cf9a1d1f", "task_id": "ncb21-task-2de1487414a9935d"}
{"benchmark_case_id": "ncb-external-transfer-54ee5bbdf18fb340", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_adhd_amygdala", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "ADHD", "control": "CONTROL", "var": "dx"}, "outcome": "smri_amygdala", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_amygdala negative for ADHD compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "54ee5bbdf18fb340fbf27b0818d752105993d52e8ffda15d7bfb15293e12da3d", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "d532a485bd849c0cb45037641ea80736f0f6016a0d923265466b91e9eb0dc5c0", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "87089c6c5d6e658961408877bdacdd7ed4a932b1f8b30924ab18d164d6dca7ba", "task_id": "ncb21-task-2e9f091011bce439"}
{"benchmark_case_id": "ncb-synthetic-stress-26a7e82fe849729e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_hcp_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_hcp_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Default", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_hcp_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "26a7e82fe849729e94eaa3edccd79c6b8c40b0dded617a4a1a155d975e6cafe4", "dataset_id": "neg_random_label_hcp_s3", "discovery_cohort": "neg_random_label_hcp_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_hcp_s3_DISC": "de0e5979bbbe65a49c04720364d4c31004127c41fc89c5f85788f40322a0fd6c", "neg_random_label_hcp_s3_REP": "321f91cbe464542c637c8d707d346ada714267ce4ac3d13869631ff1d24af4b3"}, "partition_paths": ["neg_random_label_hcp_s3_DISC", "neg_random_label_hcp_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_hcp_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f872f7492965f9046749e06d64d06581cecec12a63f2baa28fb934ddb23bcdb5", "task_id": "ncb21-task-2ee76dd03e68fbe7"}
{"benchmark_case_id": "ncb-synthetic-stress-0bb6a3a9dc5929ae", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_adhd200_s3", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_adhd200_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_adhd200_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0bb6a3a9dc5929ae8a8cdcec4aed8442f955601eae193549a7e372be736c44c3", "dataset_id": "neg_site_confound_adhd200_s3", "discovery_cohort": "neg_site_confound_adhd200_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_adhd200_s3_DISC": "f19443eb377e78d22df49b97580fb829b03dcfb39c029b5e283725569e6166bb", "neg_site_confound_adhd200_s3_REP": "fd85259d0448627da2fe5b5230a0363427862f6fd7f3d9a2e44da4d9b23c269a"}, "partition_paths": ["neg_site_confound_adhd200_s3_DISC", "neg_site_confound_adhd200_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_adhd200_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4c8fbc821a2463df7f903c2fc62b13a18e2b9223fcb00bc2d6795028893f97fd", "task_id": "ncb21-task-2efb1329959169f5"}
{"benchmark_case_id": "ncb-scientific-b0c4c5f349a00064", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_fc_adhd200_site_split", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "fMRI_FC_network_pairs", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.6, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ADHD case-control FC site-split in fMRI-FC, using ADHD200 site A as discovery and ADHD200 site B as replication, test the claim with expected direction two_sided and adjust for age;sex;site required when available.", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "b0c4c5f349a00064aea1e57a9ed87aecb684446116668a035a31fe7e2c25d086", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "9327ba43db3c8bfc32447c21feb8dc1e9768bab3c87baf1277fd377f3c97333f", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5ac814cd691bf1e1d14eefa1e9906a7d06312319770893c6522f733b0db25bd9", "task_id": "ncb21-task-2f198bcbf0cf7b42"}
{"benchmark_case_id": "ncb-scientific-e7c94f56c83e0651", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_009", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Cont_DorsAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower connectivity between control and dorsal-attention networks (fc_fc_Cont_DorsAttn_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e7c94f56c83e06518cfb23793f51ccaf963a39435caaaca93bcd7d7166f65091", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3", "UKB_REP": "6da6a67cb610290a28f97b077dd2aa0e82c39161e4b3c622857cb54843df2357"}, "partition_paths": ["UKB_DISC", "UKB_REP"], "question_sha256": "9548f0e29007f9d3fc6fa0976189c4b88bb93891fe4b81ef51583e9e10bd422a", "replication_cohorts": ["UKB_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "63f0db688ca1d92f74aa49033266babd73d0ae161097ee8b6fa86d1e494cdc26", "task_id": "ncb21-task-2f2394534763a048"}
{"benchmark_case_id": "ncb-scientific-ec6d0cdd670ee6f6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "cobre_sz_clinical", "covariates": ["age", "sex", "site"], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For schizophrenia clinical anchor in psychosis, using COBRE as discovery and FBIRN/SZ_JH as replication, test the claim with expected direction two_sided and adjust for age;sex when available.", "replication_cohorts": ["FBIRN_REP", "JH_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "preregistered"}}, "contract_sha256": "ec6d0cdd670ee6f647b9d7beb7a19415bd2f41ceeb82613f17a2f3f0fdaefbd5", "dataset_id": "COBRE", "discovery_cohort": "COBRE_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"COBRE_DISC": "f53b3405d06487a9d268b89165605cc0ed60d2c3a68e41f8ebe73660d9916d79", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "JH_REP": "f40fac0acd9aa1425552a409658e883651432d578db1db8a9c290e2ea4850ae6"}, "partition_paths": ["COBRE_DISC", "FBIRN_REP", "JH_REP"], "question_sha256": "10685a7400f926e4fa739e217543cee70f5a9bbac376fd29256dcca75c636c8b", "replication_cohorts": ["FBIRN_REP", "JH_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "93a5ad352c27f2ec6bce80c18c9672ca185b5955d003fb67c4338614d22b063a", "task_id": "ncb21-task-2f3eeb38f5c0d7d2"}
{"benchmark_case_id": "ncb-external-transfer-8a63ea377d95958e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_pallidum", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "positive", "group": {"case": "SCHZ", "control": "CONTROL", "var": "dx"}, "outcome": "smri_pallidum", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_pallidum positive for SCHZ compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "8a63ea377d95958e3b3536ba261c1af8ce07ca37dc78ed751501c82f03a8f0eb", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "98a2ea90a3062fc789dae0648a096080e92a931adc16e88a675f8f733844d471", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "12724afce26281ba85171ab20307569be5b0f35eb025df654dd83f7adb1a3a46", "task_id": "ncb21-task-2fdbf0b5a11d962f"}
{"benchmark_case_id": "ncb-scientific-acb1371a4d55e5b6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_005", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Default_SalVentAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with higher connectivity between default-mode and salience/ventral-attention networks (fc_fc_Default_SalVentAttn_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "acb1371a4d55e5b67d2d06ead7f73f437ea8d35c88a4fe46cbd67148b6955944", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3", "UKB_REP": "6da6a67cb610290a28f97b077dd2aa0e82c39161e4b3c622857cb54843df2357"}, "partition_paths": ["UKB_DISC", "UKB_REP"], "question_sha256": "0f95eab306534d82d2c25aa789d7b0145508c7161412e1c1a7dc75893a845bfc", "replication_cohorts": ["UKB_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1bed342b372aa99d3734ec9faa91e63156571e9cc04e9d6ed6d92ce916f3c947", "task_id": "ncb21-task-31b5436965a2340b"}
{"benchmark_case_id": "ncb-synthetic-stress-effa2f259eb5a69f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_oasis3_fmri_s3", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_oasis3_fmri_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_oasis3_fmri_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "effa2f259eb5a69f4c6f0f9a1ae404244d53a928e5eab8701c7438a1ad9f6225", "dataset_id": "neg_site_confound_oasis3_fmri_s3", "discovery_cohort": "neg_site_confound_oasis3_fmri_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_oasis3_fmri_s3_DISC": "1e0157c0b95469f07b9fb60d3b6953048b0a17e79e6e290592ce0eef8b3e621e", "neg_site_confound_oasis3_fmri_s3_REP": "244f5e02f11a668f82484a79e45b39db53e6d3b88773ea32a4a1793536288cf8"}, "partition_paths": ["neg_site_confound_oasis3_fmri_s3_DISC", "neg_site_confound_oasis3_fmri_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_oasis3_fmri_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6d825d1333d6938d581c3af7c8bee7f31193ff9c8db85d129d93601898eba86a", "task_id": "ncb21-task-3206b7580a2d607a"}
{"benchmark_case_id": "ncb-synthetic-stress-e1ef0d8ef65b2b01", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_adni_s1", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_p_fishing_adni_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_fusiform", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_adni_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 8, "selection": "discovery_only"}}, "contract_sha256": "e1ef0d8ef65b2b01a4d27a3acdea5f300b83e9f80cbd970fb65ad51bb0fb86d4", "dataset_id": "neg_p_fishing_adni_s1", "discovery_cohort": "neg_p_fishing_adni_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_adni_s1_DISC": "49ae200d6c34368f8f60de6d677dac4707a9528610e43411a18fe1d14e4da8b9", "neg_p_fishing_adni_s1_REP": "5def0d03573fac5041af664d2c62fe3eb5d1ab37253b9d04a9d573324f2dcaa7"}, "partition_paths": ["neg_p_fishing_adni_s1_DISC", "neg_p_fishing_adni_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_adni_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "0913e9b2ff163133c0ca7d955641fea14a538c60924c75bff9adeedf513a5796", "task_id": "ncb21-task-325bb98556bcf489"}
{"benchmark_case_id": "ncb-synthetic-stress-bd117704d246d32d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_adhd200_s3", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_adhd200_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_adhd200_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bd117704d246d32da39873e61d9d7e51a0f5b69b20e12c5c4d7da55ebc03a797", "dataset_id": "neg_underpowered_adhd200_s3", "discovery_cohort": "neg_underpowered_adhd200_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_adhd200_s3_DISC": "f311e7a94c4c7e297ef466f46608928a5e3245eed4876253ad3c1408ead5d285", "neg_underpowered_adhd200_s3_REP": "f5ea518b88a7ebfcbb8163f1ede48333d01d9465a9a9bcb507116bfce8c5de76"}, "partition_paths": ["neg_underpowered_adhd200_s3_DISC", "neg_underpowered_adhd200_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_adhd200_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "01045dae4520a84bdb276d68e057ad50feef75a5060b8e015792635dcbd4efcf", "task_id": "ncb21-task-327636a510045927"}
{"benchmark_case_id": "ncb-scientific-43b88d75579673af", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_014", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, is higher age associated with altered control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for sex and cognition?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "43b88d75579673af885b371f0652ded9c324f9b8bf3da288fe57fd77b533156d", "dataset_id": "HCP", "discovery_cohort": "HCP_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["HCP_DISC", "HCP_REP"], "question_sha256": "8c60c67016bf8bad6fc157c929d3f5c36000c6fe72086ada05045874219ac4a6", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7a55958502b94355a8fb1acfe8ef54cfdcbf4bfe1d510c98236d0e6b02b09525", "task_id": "ncb21-task-3349e65b82ed72aa"}
{"benchmark_case_id": "ncb-synthetic-stress-a9f4010d6ed3964c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_ukb_s1", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_ukb_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SalVentAttn_z_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_ukb_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a9f4010d6ed3964cedcb1b3d1a03a9cd9aeff891a467cb43968af9362f4ce406", "dataset_id": "neg_underpowered_ukb_s1", "discovery_cohort": "neg_underpowered_ukb_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_ukb_s1_DISC": "0360d4e962f989be298451651a44968f51531c23577b2d6fcd74a814f168d392", "neg_underpowered_ukb_s1_REP": "ffa42691a02c6527a38aaee42f8adec068c02756debe457a7c888e1828152f90"}, "partition_paths": ["neg_underpowered_ukb_s1_DISC", "neg_underpowered_ukb_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_ukb_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6106fbe0513c380e6ed928d3f44c0060c3d72ae7060055a88cc97bc96bfa046e", "task_id": "ncb21-task-3353a2c3c630ad15"}
{"benchmark_case_id": "ncb-scientific-3700ad906c849ad5", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_011", "covariates": ["age", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_Default_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, do females and males differ in default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for age and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3700ad906c849ad53fa7bd2bdd91cad428c07057952f31ecea37b17a562b5aa9", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3", "UKB_REP": "6da6a67cb610290a28f97b077dd2aa0e82c39161e4b3c622857cb54843df2357"}, "partition_paths": ["UKB_DISC", "UKB_REP"], "question_sha256": "dd0cec98d7f1aac97206ba48ff4eed4d194206d7740113afc245558505ea93be", "replication_cohorts": ["UKB_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4276cda719c93424930fcd08b892345fbeffe3719e3d6bded8ec4a3349d9f6a0", "task_id": "ncb21-task-33ad70367c5e5019"}
{"benchmark_case_id": "ncb-synthetic-stress-58bbab3b5e3ff519", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_abide2_s3", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_abide2_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_abide2_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "58bbab3b5e3ff5192130326f448a328d09d03cbd6bfe5f52af370b8e1662ddfa", "dataset_id": "neg_underpowered_abide2_s3", "discovery_cohort": "neg_underpowered_abide2_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_abide2_s3_DISC": "54514c61d4f9e0a10850a62a288510912c72e15f83e84c16004cf13e119870be", "neg_underpowered_abide2_s3_REP": "05c4f6655da4afa24a6563746918b3bf3027ad9e10c054785d2a4b235ffadb28"}, "partition_paths": ["neg_underpowered_abide2_s3_DISC", "neg_underpowered_abide2_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_abide2_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "db6bc1a23a05ecb9d1c4182e39f376c214478d9357ca4256855a355dd01f55f0", "task_id": "ncb21-task-387eb118b0d0a1c9"}
{"benchmark_case_id": "ncb-synthetic-stress-06e49e0c9bfc3666", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_adni_fmri_s3", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_adni_fmri_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_adni_fmri_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "06e49e0c9bfc3666a5358fda403723fd979220c507cf65958e3638421a37f45e", "dataset_id": "neg_site_confound_adni_fmri_s3", "discovery_cohort": "neg_site_confound_adni_fmri_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_adni_fmri_s3_DISC": "6805cf849e2140fd29c4716e9878f46f517fcd456c0ae9bfdc02f2556f71764d", "neg_site_confound_adni_fmri_s3_REP": "48b6104c6b31d8df97c1f43a50c0f5faa1b14d66edee895e88b29ee03c69433c"}, "partition_paths": ["neg_site_confound_adni_fmri_s3_DISC", "neg_site_confound_adni_fmri_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_adni_fmri_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "0f3b379b8c32ebfa280be7c513cf0e34357f18fd5257d64afd98681190448b0b", "task_id": "ncb21-task-3888f34a7ee0dbb2"}
{"benchmark_case_id": "ncb-scientific-6560b15c380073ca", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q012", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with higher Default-Salience/VentralAttention connectivity (fc_fc_Default_SalVentAttn_z), with no additional covariates, and is the same direction observed in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6560b15c380073caf1f8bfe84bf2978902d6605bfe8aacd3a4262b47295b8f9f", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "a70e1f9d988aaa993e4c01e912ae225e84ea38b28a642a1cf266e866cc27c789", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5a3fc388953a1d99d7c91f108c87442103cd1d2a95f5fcea35cd97bf1f52b672", "task_id": "ncb21-task-38f81a83ea1721fa"}
{"benchmark_case_id": "ncb-external-transfer-89a3d773c1c9f79a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_parahippocampal", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_parahippocampal", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_parahippocampal negative for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "89a3d773c1c9f79a4712c25306cd05d5d4e2c0a3aa7a55fe0058099c18922dbe", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "70b6e69485b06fcde8ea25df35276c27d33dc0adb1abd6267df507d95cb457cd", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "2cfe32fc531077c2d56f45cb5130affa3f36588bf6c7627bc0b82606030e3707", "task_id": "ncb21-task-3a0c46add0ae8220"}
{"benchmark_case_id": "ncb-scientific-c82528795d17b7c6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "age_fc_ukb_hcpaging", "covariates": ["sex", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_", "predictor": "age", "region_set": "fMRI-FC_descriptors", "type": "association", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.6, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For age association with FC descriptors in fMRI-FC, using UKB as discovery and HCP_Aging as replication, test the claim with expected direction two_sided and adjust for sex;site when available.", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "c82528795d17b7c659e88c258f82c4bdc65f014ab3c9395aebbff53f8ce8f938", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_Aging_REP": "e4682154e236a020f91b7932fe75341cf7a0eed865089e5172cad83a6989e965", "UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3"}, "partition_paths": ["HCP_Aging_REP", "UKB_DISC"], "question_sha256": "f6b397b4b28300ff4f43288ee09466e26e46a3a6b5a4c1b1c606378f878bfc21", "replication_cohorts": ["HCP_Aging_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "e9532af40954d25b3a29ccf7428e612faad30103af352d45ed7f18c563be564d", "task_id": "ncb21-task-3ae580adaf8733fe"}
{"benchmark_case_id": "ncb-scientific-1954832d44d0ebd1", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q041", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered DorsalAttention-Visual connectivity (fc_fc_DorsAttn_Vis_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1954832d44d0ebd153d33a92a73ee22d02a964c7b8fcdadd30845d32219325eb", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "8bc529b5e9ad12fe39e7c2aac1e087d82346ebf78a63b62520fb568907a30ee9", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "9965bbb5327fdf974600318a00f0d626e251b8be937e9feb802ca81a3ffe5989", "task_id": "ncb21-task-3b0e41e0dc79abef"}
{"benchmark_case_id": "ncb-synthetic-stress-d240bf163611d308", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_cobre_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_cobre_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_within_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_cobre_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d240bf163611d30876554628f0a4d553ae45b913dc938dcfc373e8459ce2ece7", "dataset_id": "neg_random_label_cobre_s3", "discovery_cohort": "neg_random_label_cobre_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_cobre_s3_DISC": "8cd60181ee1832713aea27ec46923eef71c1a1a3e2f9a6fd0e29011e0556efde", "neg_random_label_cobre_s3_REP": "2bdbd6492edb124bb8f2eb6eb05c4366d54df7801c10b7e7239552ecde52af6d"}, "partition_paths": ["neg_random_label_cobre_s3_DISC", "neg_random_label_cobre_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_cobre_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "9fc38ac3f07c4455349eecb0a4ae60e7634dc6a824648ed1073f63bc64fc3625", "task_id": "ncb21-task-3b15b5d2e3f7eb9f"}
{"benchmark_case_id": "ncb-synthetic-stress-7e3903cc96c0849e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_fbirn_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_fbirn_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_within_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_fbirn_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "discovery_only"}}, "contract_sha256": "7e3903cc96c0849e496f2cca2b200435ab036d805a1bc06c5e40f25f9167eddb", "dataset_id": "neg_p_fishing_fbirn_s1", "discovery_cohort": "neg_p_fishing_fbirn_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_fbirn_s1_DISC": "8f20bc07c4b810591e72bfd7d3e7349311ba61054bae27f6887c2f0432f76256", "neg_p_fishing_fbirn_s1_REP": "fd56598185046bd5db4dea2029417e5b3de4dee09d99c48b9a995921b845af4f"}, "partition_paths": ["neg_p_fishing_fbirn_s1_DISC", "neg_p_fishing_fbirn_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_fbirn_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7851509bd3b1da36f8f6e5fbccecf14de225450f7c955b082fae73a848a0c8fc", "task_id": "ncb21-task-3c2b86d3c9fb8ae5"}
{"benchmark_case_id": "ncb-external-transfer-2bd6d96052019d32", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_thalamus", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "SCHZ", "control": "CONTROL", "var": "dx"}, "outcome": "smri_thalamus", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_thalamus negative for SCHZ compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2bd6d96052019d32457a88cd70f20e161ad4e66f4e80dd0341a62eb8fda48df9", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "1f9ae5fe25dde3265f4410daf84cefbd872f59b5af2e51dec32eb2b2ca765171", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "22f7b4e5511f67c9b714d9945ed876266923d54aa86d72f944eb725c730d28ee", "task_id": "ncb21-task-3ceb5d86a19295df"}
{"benchmark_case_id": "ncb-scientific-1f634e71dd689f9b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q042", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Limbic_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Limbic_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1f634e71dd689f9bf628ab2462201c44d5996f29424ad3bb244eae08906e402b", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "56db717c9ee711689f24e42842466bbde7048f7ace307c60d095601ab786f3b4", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "8df9db1c1f1f458cda7d70223932d137259e4ff86d92ce495b1047d2a9b51fb9", "task_id": "ncb21-task-3d093bb7bad5924a"}
{"benchmark_case_id": "ncb-scientific-cb339bf30281cede", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_026", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_SomMot_SomMot_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, is higher age associated with lower somatomotor within-network connectivity (fc_fc_SomMot_SomMot_z), adjusting for sex and cognition?", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cb339bf30281cedea3769b3c8ba3c0199ad8889c6569c72e5720af2c4c1b226d", "dataset_id": "HCP_Aging", "discovery_cohort": "HCP_Aging_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_Aging_DISC": "47082908a7b0b17d0b8a006028dff9d08a56af3f8c6e8d08627ca3818f85a4fd", "HCP_Aging_REP": "e4682154e236a020f91b7932fe75341cf7a0eed865089e5172cad83a6989e965"}, "partition_paths": ["HCP_Aging_DISC", "HCP_Aging_REP"], "question_sha256": "0aa2228a096b0e664538eeb85ad592e24e1e86c968e157af074ef47570ee4519", "replication_cohorts": ["HCP_Aging_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a301c2c36e13898584f2156b1a29e59116fbbeaa86958bf463ba6a44cf7d0288", "task_id": "ncb21-task-3d920ec7800c2bfa"}
{"benchmark_case_id": "ncb-scientific-0945ff60b5d68ba8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q034", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_entorhinal", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In ADNI_DISC, among CN participants, is older age associated with lower smri_entorhinal, adjusting for sex?", "replication_cohorts": ["ADNI_REP", "OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0945ff60b5d68ba89a298e0d5c7f9a2de1625b057bca524e15324d9708ecf806", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "ADNI_REP", "OASIS3_REP"], "question_sha256": "4cb9377ded9feb6d76bf5054a804e16afeeb4fa9f472aa35762588854bd2d7b8", "replication_cohorts": ["ADNI_REP", "OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d200db352b9163511dea58bdcde2dc1a8a423dbc3b627c10d03e4b2fe7a625c2", "task_id": "ncb21-task-3df4d7ede4eced5b"}
{"benchmark_case_id": "ncb-synthetic-stress-5d46d95ce95c931d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_abide1_s3", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_abide1_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_between_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_abide1_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5d46d95ce95c931d425092d939a6f50dcdc1c4b898ee8a25ab743a42cf29b8bd", "dataset_id": "neg_site_confound_abide1_s3", "discovery_cohort": "neg_site_confound_abide1_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_abide1_s3_DISC": "b2e6c1c31ed8f7e3638bebfc3fdbcda2e510bb8ff87b4e9947470eaefcf87ec5", "neg_site_confound_abide1_s3_REP": "d312a51e8928f6bda038bfb08bfb27f45d5e2f94ed0cfd8f909cf43db4384aa7"}, "partition_paths": ["neg_site_confound_abide1_s3_DISC", "neg_site_confound_abide1_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_abide1_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6ed3a078e9c7ff531e6dcf84a2787d7d5a73f0490274099ac0e795f39aa4b778", "task_id": "ncb21-task-3f71678ac0f44acd"}
{"benchmark_case_id": "ncb-synthetic-stress-7911d5fcc3aee4ba", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_hcp_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_hcp_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_hcp_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "7911d5fcc3aee4ba501e42669454d2fdcc137bf7f6d1feecb6bc5fd155fa4e81", "dataset_id": "neg_p_fishing_hcp_s3", "discovery_cohort": "neg_p_fishing_hcp_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_hcp_s3_DISC": "edcc6fb7f40f47f5339126417b028fe7d12a819ed651b9a302dc316987de2109", "neg_p_fishing_hcp_s3_REP": "48c98cea502be4565782630b6544089e670c67004cbb6393f902e1542cbc49d7"}, "partition_paths": ["neg_p_fishing_hcp_s3_DISC", "neg_p_fishing_hcp_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_hcp_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "69d274a60fdd9dedaa27604cb7b6d32c4e09dbc4b4275762167363d7166ec2f3", "task_id": "ncb21-task-401699c9be26d050"}
{"benchmark_case_id": "ncb-scientific-e9887ba0003df877", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_017", "covariates": ["age", "sex", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, is higher cognition associated with lower default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for age and sex?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e9887ba0003df8779438a68d1005ebb55b6bb49af3d222c23f2ed43541800f4c", "dataset_id": "HCP", "discovery_cohort": "HCP_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["HCP_DISC", "HCP_REP"], "question_sha256": "3e12a2df79028cbe48db6c4236b5c390a09a342a63a4f34fa14467293b3b627e", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b127f87ad91fdaf97401260450621a35f3f055164aecb4bd920490f8d92c454e", "task_id": "ncb21-task-402fa353a875fc7b"}
{"benchmark_case_id": "ncb-synthetic-stress-ecf6d32180cfff58", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_hcp_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_hcp_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_hcp_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ecf6d32180cfff5832719b69d9d1cf89182eafc28c198ee3bfdee483e15e47e0", "dataset_id": "neg_random_label_hcp_s1", "discovery_cohort": "neg_random_label_hcp_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_hcp_s1_DISC": "88fff01e12a1eea5892b06305ea8780d293d0eb6849301596f7739d5f338d5a7", "neg_random_label_hcp_s1_REP": "d905b234f8604551fa0b1d17a05985c3ed907b9b4273de3055b33bfa659b018a"}, "partition_paths": ["neg_random_label_hcp_s1_DISC", "neg_random_label_hcp_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_hcp_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "db02983a9a1b885bcc14a4b6015c842c3643bc521e0dbe437a07f671ee88c622", "task_id": "ncb21-task-4118bcb674d1553f"}
{"benchmark_case_id": "ncb-scientific-721c4fa75e038ea4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q035", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered Control-Visual connectivity (fc_fc_Cont_Vis_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "721c4fa75e038ea4bdb26ce48b91b63d0615507f3c7e11e3dd07f46967efa967", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "c4b2a6558b62d2bad18bd86b91ef2e94d8b31723993242852cbdb8c3dcf9f092", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "cfbb4ae53271cff2f6c6f7b98b15c13304aad2c4c5da00ae7c901f76cd99261f", "task_id": "ncb21-task-4119b3d43abfec30"}
{"benchmark_case_id": "ncb-synthetic-stress-1cb9ec13d30f0e3b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_abcd_s3", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_abcd_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_abcd_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1cb9ec13d30f0e3bd8995e37bc0c969112fdfe2227f63692d0a1fae6fb256d58", "dataset_id": "neg_underpowered_abcd_s3", "discovery_cohort": "neg_underpowered_abcd_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_abcd_s3_DISC": "7e83e646b7bcf3a6f7fdaa5c34acbb6cd2926284eac8715d64ca9aeeee4f8a90", "neg_underpowered_abcd_s3_REP": "28eccea410de928a6a6f5e7f82087509f917b6abf623f757a2a8422024ca4543"}, "partition_paths": ["neg_underpowered_abcd_s3_DISC", "neg_underpowered_abcd_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_abcd_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7b4bc1f1557ab592ae5868939434f4c6a452d3ebd703ae4a1a16b15722a633bd", "task_id": "ncb21-task-41530f6a50c4e47b"}
{"benchmark_case_id": "ncb-scientific-9181e305d0e360a5", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q024", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_REP, do SZ and HC groups differ in fc_between_network in an unadjusted comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9181e305d0e360a5d17ec43febd9d32a46fc572a1fa87ab8680c7b4cb79abe90", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "question_sha256": "13054da604d3991a2fb72837b3c7c4bcc617d91a730fe2a6dd173d5bd4704510", "replication_cohorts": ["BSNIP2_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f9db43e6f72307ea7100188fa90179ca49373155e2ee2a9897a7dc46537b90b9", "task_id": "ncb21-task-4500dc8037b51034"}
{"benchmark_case_id": "ncb-scientific-2da7ae8514465754", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_004", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with higher connectivity between the default-mode and dorsal-attention networks (fc_fc_Default_DorsAttn_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2da7ae8514465754088a9e1b59a38f021dec2a48c9ba27749492356ee704e952", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3", "UKB_REP": "6da6a67cb610290a28f97b077dd2aa0e82c39161e4b3c622857cb54843df2357"}, "partition_paths": ["UKB_DISC", "UKB_REP"], "question_sha256": "e901b905a0a8a04497a5aa6b51dc1ec627ded00b08b0dc9b702170661ed9e948", "replication_cohorts": ["UKB_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f97719647507bc92d8ea51aa00b032788d435a2a086cbc109cecb5a36d9e53dd", "task_id": "ncb21-task-46aa865267479f06"}
{"benchmark_case_id": "ncb-external-transfer-94dea5dc0bc79c8c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_caudate_random_label_s20260747", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_caudate", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_cnp_scz_caudate.", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "07b5ce391445bb3372d9a20b6547a7aa28b023d95441930e2ded99807341354d", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "0c3ddca863267b3cada16f8c99b069d8d7e15a7000158e30905adc5519a9be7e", "selected_assignment_rows_sha256": "eb86b1f43363990636d768f8649af4efe79f5f99278b9748fee1cdd607fe6832"}, "generator_spec": {"assignment_count": 265, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "eb86b1f43363990636d768f8649af4efe79f5f99278b9748fee1cdd607fe6832", "discovery_seed": 20260747, "group_column": "ncb_random_group", "parent_external_claim_id": "SCZ_caudate", "replication_seed": 21260747, "seed": 20260747, "selected_assignment_rows_sha256": "eb86b1f43363990636d768f8649af4efe79f5f99278b9748fee1cdd607fe6832", "type": "independent_random_group_labels"}, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "f0b6912c7bf1508bd7d141320b5ea0a5abad91d67669fd462bd5f9b896007f86", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "40c295cb57c49cf97042b4266c35406d7de24588ae9d1b51f757e6472091db1e", "task_id": "ncb21-task-46aaac00f9a0a6d1"}
{"benchmark_case_id": "ncb-scientific-9cb81ca19caf7d9d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_brainwide_smri_adni_oasis3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": ["smri_hippocampus", "smri_wholebrain", "smri_entorhinal", "smri_fusiform", "smri_midtemp"], "predictor": "confirm_dx", "region_set": "ad_regional_atrophy_signature", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 5, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.6, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For AD regional atrophy signature in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 5, "selection": "preregistered"}}, "contract_sha256": "9cb81ca19caf7d9d6b49e500a49ea556a78744f64b6fd83c145fea8fe986637c", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "97be5076603be9d917c886dc45ede9e795636baad44684b76a809bc66b0edc5c", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b163327a1cf450d5f3da5346f19f8b4715011e0094f8209838dfcb2ea37c9a64", "task_id": "ncb21-task-47e6d67533617281"}
{"benchmark_case_id": "ncb-scientific-113ed00f0e74744d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_fc_adhd200_internal_split", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ADHD case-control FC derivative-table split in fMRI-FC, using ADHD200 as discovery and ADHD200 as replication, test the claim with expected direction two_sided and adjust for age;sex when available.", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "113ed00f0e74744db73352da4d1cfd37e82cf767a06d5337e03d01bb71cc92a4", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "554a74d9315bf8cfe6d04a629796d126dbf2a0d82f46b7799c423392a6f62b3b", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "739a6bf0200023dbd5e0eb4be6a12b387623aee6f2d42f5853a1a52720d53b7f", "task_id": "ncb21-task-47e7b5c1a1f25442"}
{"benchmark_case_id": "ncb-external-transfer-6c51801ff315cd4f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_wholebrain_random_label_s20260728", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_wholebrain", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_ad_wholebrain.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e564a621e4371feb2bf65ed392edd8a05f416d9d447ddce9d5b0f15a4012e8ea", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "8cec5816198bb3ede765a88aa15cea45225a71ce9f52e26960681316162a1c0a", "selected_assignment_rows_sha256": "019c04868259f64f31b05bdb3b1c958d5cca91d6b0071170d1778fe54ee9f2e5"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "019c04868259f64f31b05bdb3b1c958d5cca91d6b0071170d1778fe54ee9f2e5", "discovery_seed": 20260728, "group_column": "ncb_random_group", "parent_external_claim_id": "ad_wholebrain", "replication_seed": 21260728, "seed": 20260728, "selected_assignment_rows_sha256": "019c04868259f64f31b05bdb3b1c958d5cca91d6b0071170d1778fe54ee9f2e5", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "5144d27e87d735c369a9087cd657070017727b610b63676f3d2722bf228bcc6c", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1650324e6488783c1bd8f3f97cf01db74a14eed99474009f082526622a311664", "task_id": "ncb21-task-4875a681d27f91e0"}
{"benchmark_case_id": "ncb-scientific-3578a76ed8bf3578", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q006", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_fusiform", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with lower smri_fusiform than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3578a76ed8bf35781d498f17e97f52809043ab7d6566b7a2316e03be5b46504f", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6"}, "partition_paths": ["ADNI_DISC", "ADNI_REP"], "question_sha256": "2f6325a24e29ccb5dbac738603e08ff3b2edbca45205fd57e7b6cce8d1da9f03", "replication_cohorts": ["ADNI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "014895b946bf4421b4533b61fa55ab2a6e3cd1e8685cefbb66a842cf0e4de3a4", "task_id": "ncb21-task-488d5612e99b3300"}
{"benchmark_case_id": "ncb-scientific-7c005de1c12b32a7", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q023", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "positive", "group": {"case": "3", "control": "0", "var": "dx"}, "outcome": "fc_fc_SalVentAttn_SomMot_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx in [\"0\", \"3\"]", "question": "In ADHD200_DISC, does ADHD-hyperactive/impulsive type (dx=3) versus control (dx=0) show higher Salience/VentralAttention-Somatomotor connectivity (fc_fc_SalVentAttn_SomMot_z), with no additional covariates, and is the same direction present in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "22e9dad3dc77b808e6883b1259492c9cf8f1bb52d57623e5d3afd28fd4ecd81a", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "af8cd98c7b6f26a204bc6fac60ce7fdcd95301834414de7f8837e25b758e1b22", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "afd979c1a5acc5968516aa285022d6e3eea5fcd67466bcc45b0dd081980a11db", "task_id": "ncb21-task-4909693e2ac000b8"}
{"benchmark_case_id": "ncb-scientific-b6bcaf52ce24d411", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q033", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered DorsalAttention-Visual connectivity (fc_fc_DorsAttn_Vis_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "b6bcaf52ce24d41101405c05556ff4df7a5cf370d247fb9fbe590d817921a011", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "4534f60aebd59bf411dff332e7d4aa2e530c34c5d20aafc1bd860b07358677cb", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "93603ccca3b3f6804922643703b6d1b7114815aa09b22a6552ac7771422f096e", "task_id": "ncb21-task-4958fc673b892c35"}
{"benchmark_case_id": "ncb-scientific-1bc0eeed8b9a00bc", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_030", "covariates": ["age", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Cont_Limbic_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, do females and males differ in control-to-limbic connectivity (fc_fc_Cont_Limbic_z), adjusting for age and cognition?", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1bc0eeed8b9a00bcce2b16c492833a958ed447237b1b30b729a3a74a70d428bf", "dataset_id": "HCP_Aging", "discovery_cohort": "HCP_Aging_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_Aging_DISC": "47082908a7b0b17d0b8a006028dff9d08a56af3f8c6e8d08627ca3818f85a4fd", "HCP_Aging_REP": "e4682154e236a020f91b7932fe75341cf7a0eed865089e5172cad83a6989e965"}, "partition_paths": ["HCP_Aging_DISC", "HCP_Aging_REP"], "question_sha256": "53bbcf6a2b0a61878655e2e0d64b3a5ac9128bdced0680878f27860708d8d09a", "replication_cohorts": ["HCP_Aging_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "51ebc78f165428d1940fb45573c1115a6f102e4b3919f9dfaf2a4809867f549f", "task_id": "ncb21-task-4990a40bd94c76a7"}
{"benchmark_case_id": "ncb-scientific-c922885057dbc163", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q032", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "smri_ventricles", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In ADNI_DISC, among CN participants, is older age associated with higher smri_ventricles, adjusting for sex?", "replication_cohorts": ["ADNI_REP", "OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c922885057dbc163bc0da7c09a1f929618f4043b01e964bfbd4ba2d3947e992e", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "ADNI_REP", "OASIS3_REP"], "question_sha256": "53fa251788a35110e095f3a21563ed929421af399dc979f6c4aa653fe49e89bf", "replication_cohorts": ["ADNI_REP", "OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f3dc0ac494a0ed981fbab4e790bc4b2193f7bc8a0ca61cd46ce52328aa075fcd", "task_id": "ncb21-task-49c64dd2a4b213fa"}
{"benchmark_case_id": "ncb-scientific-30329250c399e0e1", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q050", "covariates": [], "discovery_cohort": "ABCD_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ABCD_REP and ADHD200_REP, using each cohort's available ADHD-control coding separately (ABCD dx=1.0 vs 0.0 excluding missing dx; ADHD200 dx in {1,2,3} vs 0), is the ADHD association with within-Default connectivity (fc_fc_Default_Default_z) directionally consistent, with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "30329250c399e0e19f0099ec82e0f1abd36cca45c0178fcdc6800cf75650db9e", "dataset_id": "ABCD", "discovery_cohort": "ABCD_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ABCD_REP", "ADHD200_REP"], "question_sha256": "ad29c03c753cb54fc63c9e2bb9e55406d97ceb5211366e8a3fab4dbdf61828c4", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5deeec04029a5eef363857c98860bb794bc22a3e4c16594cf5a108d8aa6a88ae", "task_id": "ncb21-task-4a3386676b1444ee"}
{"benchmark_case_id": "ncb-scientific-8d7c71367a2043b9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q008", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_HOLDOUT", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_HOLDOUT, does fc_between_network differ between ASD and HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_DISC", "ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "8d7c71367a2043b90fd51104e7c42a5e0fbd4068a2810fc8c3cbff83c8af75e6", "dataset_id": "ABIDE1_HOLDOUT", "discovery_cohort": "ABIDE1_HOLDOUT", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE1_DISC": "5a174cbcac2a070ea3f3af8be549a18c404215aaa031137242335f4c83643da4", "ABIDE1_HOLDOUT": "465b83b9275d056ca897367bc2b30907c1b32663d2fd4cdda4f87111fedb541c", "ABIDE1_REP": "d0a670f11f1c39a32e1e182cd1457b51acbec5518845795c26872642565c9f35"}, "partition_paths": ["ABIDE1_DISC", "ABIDE1_HOLDOUT", "ABIDE1_REP"], "question_sha256": "b29948934ba0a84db7bb402482c14d92902908ec3ef781d63f7e22cb7ec73fac", "replication_cohorts": ["ABIDE1_DISC", "ABIDE1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "37bb2c7080e51844d479f9f7c868a2733e69e5715c9cd57c408cc19c7938e422", "task_id": "ncb21-task-4a89eea2ea597161"}
{"benchmark_case_id": "ncb-synthetic-stress-5f540298959b95f9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_cobre_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_cobre_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_mean_positive", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_cobre_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "discovery_only"}}, "contract_sha256": "5f540298959b95f909c37ceae40f9919dc825eff3f873a7f4929af239d5c86db", "dataset_id": "neg_p_fishing_cobre_s2", "discovery_cohort": "neg_p_fishing_cobre_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_cobre_s2_DISC": "b7497a8274575664e5804beb3e11cffef1329604817545706973acc29035c1a3", "neg_p_fishing_cobre_s2_REP": "4959eab5cfd45d70d7c92b04d1d9ae8739e83de8a0a6be69691d1f8ad4ce161a"}, "partition_paths": ["neg_p_fishing_cobre_s2_DISC", "neg_p_fishing_cobre_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_cobre_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "50a820e6dc0b2e69c0d9c8460e710db4aad548c6c963eaa13ef3c37e11a96818", "task_id": "ncb21-task-4b7a7370c57ed067"}
{"benchmark_case_id": "ncb-external-transfer-092cd51bcb5448d7", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_wholebrain", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_wholebrain", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_wholebrain negative for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "092cd51bcb5448d733b56f9f575e9408342772b0c4744746991ea25c18cddf68", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "bd3ddaf56e9032d6155c6041b4ff21d5664b86d3a079c7447fdf3361cbda933d", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "886116f9783d4ba77603282fac2bcce7ee5d7f6ed35310f9881c945ed0c1ce9a", "task_id": "ncb21-task-4cedbea84f9b30c0"}
{"benchmark_case_id": "ncb-scientific-86a81a5f3a28d98c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_040", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_Limbic_Limbic_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher age associated with altered limbic within-network connectivity (fc_fc_Limbic_Limbic_z), adjusting for sex and cognition?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "86a81a5f3a28d98c10f2fd88774a049275a6dd3a56fa4e236ed763a643cae1c7", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "5aa37301cb74ff753caaa31679db6a52f02d81730fda044d462d42b8f9d71f2b", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c19c60b2d92e0cf484c84704ca8d74476e7ad50eb5e59e1b12efc9c391f1e9c1", "task_id": "ncb21-task-4cfe9f0fdd4439d5"}
{"benchmark_case_id": "ncb-synthetic-stress-9ec90396df1939bd", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_abide1_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_abide1_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_within_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_abide1_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "discovery_only"}}, "contract_sha256": "9ec90396df1939bd27c15a13598171bcdce7b4bbe53c705777a1c1eee213293d", "dataset_id": "neg_p_fishing_abide1_s2", "discovery_cohort": "neg_p_fishing_abide1_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_abide1_s2_DISC": "f64fdb9a022b4cf1fa4c6b6340e35e5eaddbaa257230ef9e63010c314b199492", "neg_p_fishing_abide1_s2_REP": "a40b68b8e76af370e59f1c30ebc454f5d2679aa25b80a4a2d7adb7f91acf785a"}, "partition_paths": ["neg_p_fishing_abide1_s2_DISC", "neg_p_fishing_abide1_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_abide1_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "67c16a035b56da6d418845f8283318bf60ce432296f042889964074d9e4a0bd4", "task_id": "ncb21-task-4d29f1cd3fe7b809"}
{"benchmark_case_id": "ncb-external-transfer-4f545e6dc827f451", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_lateralventricle_random_label_s20260746", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_lateralventricle", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_cnp_scz_lateralventricle.", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "606cbc9e2a0469071a69378c251e92a1f730bcfd089b44998ba2b1244e1335b2", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "52bc760fb11009dc257f9f4c50f29daea7f5a1568dcb58effcb0c2bfedd240ad", "selected_assignment_rows_sha256": "9d98e9c299fc9d30c5247ebe0d82da37a773838587c14bdf1a849485f4f08e53"}, "generator_spec": {"assignment_count": 265, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "9d98e9c299fc9d30c5247ebe0d82da37a773838587c14bdf1a849485f4f08e53", "discovery_seed": 20260746, "group_column": "ncb_random_group", "parent_external_claim_id": "SCZ_lateralventricle", "replication_seed": 21260746, "seed": 20260746, "selected_assignment_rows_sha256": "9d98e9c299fc9d30c5247ebe0d82da37a773838587c14bdf1a849485f4f08e53", "type": "independent_random_group_labels"}, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "62627f4c4958f2e6d755afe24678846d565b76e8bce130b79462859512819ff9", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "196b3b9acd5079a744d4f71c1705c34954c263932909ae301aac392bf055400a", "task_id": "ncb21-task-4d686e6eead8d927"}
{"benchmark_case_id": "ncb-synthetic-stress-c1154a14cd1e8ef3", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_gsp_s3", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "neg_site_confound_gsp_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_hippocampus_lh", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_gsp_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c1154a14cd1e8ef3b126b9675ee914ce9f75b8386f859727c4d6a10e8f2a6d21", "dataset_id": "neg_site_confound_gsp_s3", "discovery_cohort": "neg_site_confound_gsp_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_gsp_s3_DISC": "bb71aef3fc8fae65e104f0768e7da00f0c7317b56e5a62bce170edf16ce56561", "neg_site_confound_gsp_s3_REP": "324e4441c5a9eb70bddfefdf354e210ef5c0552b25965dfb9738825b582c5333"}, "partition_paths": ["neg_site_confound_gsp_s3_DISC", "neg_site_confound_gsp_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_gsp_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "47948a43c2f83d217724660b17ffbe967042ca94bcdf613b71b85b5a7d5d9ab0", "task_id": "ncb21-task-4d6ae499db45b0e9"}
{"benchmark_case_id": "ncb-synthetic-stress-98bf3913e77b446e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_abide2_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_abide2_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Default", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_abide2_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "98bf3913e77b446e6773a72465287f8a626b7b4d978f3e6f77c60f479620d72f", "dataset_id": "neg_random_label_abide2_s3", "discovery_cohort": "neg_random_label_abide2_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_abide2_s3_DISC": "d8b4b7ef5beb12941ce9702d985736156bab0c1ad9bdf35f8c1557ba4b82ca7b", "neg_random_label_abide2_s3_REP": "4ea490ff549e1ffcb193815a532d7a60af37b6f349d45fc985a1413e390c1a34"}, "partition_paths": ["neg_random_label_abide2_s3_DISC", "neg_random_label_abide2_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_abide2_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "84535acf2862b838dd7561d8fa500aa1ef11b88cfe504468784447e13bad5206", "task_id": "ncb21-task-4e5dd8514f0717d7"}
{"benchmark_case_id": "ncb-scientific-266504b3d4e53721", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q002", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_DISC, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted two-group comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP", "COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "266504b3d4e53721e07a0d77932a5254a3379c3ddf34b0dc44aeea4c4b4cb67d", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_DISC", "COBRE_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "question_sha256": "30fec9a8456c7a1a81f49d28b613b729ca6541e03089a86ccdeeae00b8686a65", "replication_cohorts": ["ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP", "COBRE_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "2a067805cdcdcba58086ac64f1b7fd2a26ab2cadc95417359d47b7cd637e2146", "task_id": "ncb21-task-4e76d5dc01d8b134"}
{"benchmark_case_id": "ncb-scientific-7fe9235c8d5841b2", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q022", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7fe9235c8d5841b21b4e02f5f1ea3da19d265b3dae41e4689eb549064708d519", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "8006929afd02e83488b6b126559c6871c27e67f92e44168157621b5323681d50", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b3c6ea4e5788f95c4b4d4933521dd03c467139c479d75d0309f068ff344958e8", "task_id": "ncb21-task-52fb8c2bbe143797"}
{"benchmark_case_id": "ncb-scientific-f38be8ab6a8f07ce", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "sex_fc_ukb_hcp", "covariates": ["age", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_", "predictor": "sex", "region_set": "fc_fc_descriptors", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For sex association with FC descriptors in fMRI-FC, using UKB as discovery and HCP as replication, test the claim with expected direction two_sided and adjust for age;site when available.", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "f38be8ab6a8f07ce1df876772b2b2987abfe8d7da0a73638f07bf09b7f8218f9", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba", "UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3"}, "partition_paths": ["HCP_REP", "UKB_DISC"], "question_sha256": "7e06971cb92409b74cf0be5e7f4bfe07c0a2679d8b49d129f16516602aa3b07c", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "64a71a6d0dd7b1709aeb115b7ec368ccaf81fd496949fb98e14636ca7745b253", "task_id": "ncb21-task-5385bb3754a4a4b3"}
{"benchmark_case_id": "ncb-scientific-1d2a9e0f4f0b8bc3", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q038", "covariates": ["age", "sex", "site"], "discovery_cohort": "OASIS3_fMRI_DISC", "estimand": {"direction": "negative", "group": {"case": "2", "control": "0", "var": "dx"}, "outcome": "fc_fc_Cont_Default_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_fMRI_DISC, with OASIS3_fMRI_REP as a replication cohort, is diagnosis code 2 associated with lower fc_fc_Cont_Default_z than diagnosis code 0, adjusting for age and sex?", "replication_cohorts": ["OASIS3_fMRI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1d2a9e0f4f0b8bc35fe53e1c18e110f8965f0dbb01897b1aba0cbe4d193e5821", "dataset_id": "OASIS3_fMRI", "discovery_cohort": "OASIS3_fMRI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_fMRI_DISC": "7b701bee5bf1a2e4ded9c29c25ca16bc6ef6980169d9873326b362e29ecfa14d", "OASIS3_fMRI_REP": "b3ca261941658ec5a84c1f6f268e2261777e1bcd23bf28c7d2abe42d646aa786"}, "partition_paths": ["OASIS3_fMRI_DISC", "OASIS3_fMRI_REP"], "question_sha256": "8b20c9be920cca4814ccd228983288411d29bafc0dc4294a7aee1addbfc71e56", "replication_cohorts": ["OASIS3_fMRI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "49f6600c1420b9f947402850010bcf48b2bedfe8b4dd28bb185500411179a15f", "task_id": "ncb21-task-539310d53e198d22"}
{"benchmark_case_id": "ncb-scientific-0f508c95b4a3bf2f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_32726311_pmid32726311_ent_resistance", "covariates": ["sex", "eTIV"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "smri_entorhinal", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "For literature-grounded Older age among cognitively normal adults, with regional contrast involving entorhinal cortex effect on Entorhinal cortex age-related atrophy or MRI integrity in combined functional-structural MRI in the primary study; structural MRI in secondary analyses, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction two_sided and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0f508c95b4a3bf2f8378534e90302d62391a9fa42ce7d40f63b60d7d76091c99", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "369145284d194fe1ac5a6007ba75dfe2b1a2f431fdb95d7e0b415b41597567a0", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1459c5ad026f1a2e9fef47cae988352948ad6e63bfa00a67e3c909e0b186bc02", "task_id": "ncb21-task-53aa9c77ecfafcc8"}
{"benchmark_case_id": "ncb-scientific-f38d6fdbc4e79d95", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q043", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Control-Visual connectivity (fc_fc_Cont_Vis_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f38d6fdbc4e79d95965379c89ad839dad19e0303155a580a4d7bcd26ddf9a32d", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "ee68ae43c36d7e8041d4e3c3fc5f38ae133a163b0149de359965b8387562f7ee", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ca8899153ff206ecae725a3354c4d3067f1a0e5ea57dca70ce25121616ede35b", "task_id": "ncb21-task-55a3ba277e248b31"}
{"benchmark_case_id": "ncb-synthetic-stress-9b50e1327c3e6c6a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_adni_fmri_s1", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_adni_fmri_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_adni_fmri_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9b50e1327c3e6c6aa2c6aa65871a90437554052edb078f027664ce1fc00215ed", "dataset_id": "neg_site_confound_adni_fmri_s1", "discovery_cohort": "neg_site_confound_adni_fmri_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_adni_fmri_s1_DISC": "56cf1fc1de77f1ea2f0aa3705858d3cfdc917e7476d0291af58d0579ca9ab69a", "neg_site_confound_adni_fmri_s1_REP": "48ccf92a3427aeaf99820f8ca81f05f92a57083967229fda3e3cb060097bf977"}, "partition_paths": ["neg_site_confound_adni_fmri_s1_DISC", "neg_site_confound_adni_fmri_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_adni_fmri_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5cf58947e067d16c85da823f9cebd2508845dc6aaca5e1775306fd3947a6ed9b", "task_id": "ncb21-task-5619589f08060ff8"}
{"benchmark_case_id": "ncb-synthetic-stress-54c17f36d0f78ac8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_oasis3_fmri_s2", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_oasis3_fmri_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_oasis3_fmri_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "54c17f36d0f78ac84dfdc0a179b23b3cd6b24b6f4ab4864ce8448e189a4f70b6", "dataset_id": "neg_site_confound_oasis3_fmri_s2", "discovery_cohort": "neg_site_confound_oasis3_fmri_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_oasis3_fmri_s2_DISC": "52c071a51adda3c66cf2ac10fc7de57dd6d1af22fdcad51ee20f0f561d93a779", "neg_site_confound_oasis3_fmri_s2_REP": "14e44ade0a39fd24d9e24efb072521c9c2701e37cebe09fb50dd42be7928ae9a"}, "partition_paths": ["neg_site_confound_oasis3_fmri_s2_DISC", "neg_site_confound_oasis3_fmri_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_oasis3_fmri_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a8cda5bfc43728c0e930f56ed2f103a69c563381d2ee64aa3bd80180cf601c66", "task_id": "ncb21-task-570497b221f3a3b4"}
{"benchmark_case_id": "ncb-scientific-e43def8c3b8cb4e9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q026", "covariates": ["age", "sex", "site"], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In FBIRN_DISC, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e43def8c3b8cb4e9401abd45c8e585ca3fb7555ed77364cdacf981560d643998", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_DISC": "5a9a103412824c97ff34a4b7c9107198e9309be14f345c917761eb11adcdbd82", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "FBIRN_DISC", "Olin_SZ_REP"], "question_sha256": "e99e3b5e8064869b751e6cda75c26be803b602132104ce8ce51c4d5fd60cf459", "replication_cohorts": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "55037708c84a264715f67a9d65743dd29b7ae0b6c38b838b4c18430c1c6ed8d1", "task_id": "ncb21-task-57b20f6c2d349598"}
{"benchmark_case_id": "ncb-scientific-bdabe2252485052d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_21729419_pmid21729419_1", "covariates": ["age", "eTIV", "sex"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_", "predictor": "confirm_dx", "region_set": "smri", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "eTIV", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 6, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded clinical dementia diagnosis or dementia-related disease group effect on regional/global cortical atrophy in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction positive and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 6, "selection": "preregistered"}}, "contract_sha256": "bdabe2252485052d7dc57af8fa2e2b0c2ff1a6f8ceb218cf47d53bc6ff965cdd", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "afdd0d516b0e02ac11ff3e32a5a41532121f371c8b0d407f13ce0e2c6f41a3af", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "29980e4edc1ac46d117411d465e4ad43940dcb1be6bc2c4567f937bab48780ea", "task_id": "ncb21-task-57c0fb95d68b794c"}
{"benchmark_case_id": "ncb-scientific-9586a5c1af2ea3f7", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "underpowered_asd_site_abide2", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "fMRI_FC_network_pairs", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.6, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ASD small-sample fragile FC stress in fMRI-FC, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "9586a5c1af2ea3f750efc9fab6e0024a5faa97fed0023cb8ccc5845173e180c0", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "036c278deb19fda270b0513ebefa1fd8ae0019ed63583b6d97c6a48d5b773c2a", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "bb0de2d1230921d3aa2561c2e50a6aca4e50ac965bae47daeff7be1f0e29ddfd", "task_id": "ncb21-task-584ab4cfafce706b"}
{"benchmark_case_id": "ncb-synthetic-stress-5eb1caa641a44211", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_adni_fmri_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_adni_fmri_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_SomMot", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_adni_fmri_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "5eb1caa641a4421113758eeee38a873b1e71b62ce4115c1d49542f5df041adbd", "dataset_id": "neg_p_fishing_adni_fmri_s2", "discovery_cohort": "neg_p_fishing_adni_fmri_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_adni_fmri_s2_DISC": "4c5ac25e4c2916bfc197bf847d25ac9ccb714f29a34d848d085e99f3882ea8de", "neg_p_fishing_adni_fmri_s2_REP": "58769e299dc65fca1df148b23b81ba004e6e0c73939ea26900b58bfaf145511e"}, "partition_paths": ["neg_p_fishing_adni_fmri_s2_DISC", "neg_p_fishing_adni_fmri_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_adni_fmri_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "3e47d5e75fbc554fc9f2fdee4a4b19ae4b2fb7279b1b75f372a30170cabd04e5", "task_id": "ncb21-task-58bcd93a44b2249d"}
{"benchmark_case_id": "ncb-scientific-83e09f86b797842d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q004", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_DISC, with replication assessed in ABIDE1_REP, does fc_between_network differ between ASD and HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "83e09f86b797842db14cf907d844db23b34efc9e14034f96c3ccdb763c272e12", "dataset_id": "ABIDE1", "discovery_cohort": "ABIDE1_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE1_DISC": "5a174cbcac2a070ea3f3af8be549a18c404215aaa031137242335f4c83643da4", "ABIDE1_REP": "d0a670f11f1c39a32e1e182cd1457b51acbec5518845795c26872642565c9f35"}, "partition_paths": ["ABIDE1_DISC", "ABIDE1_REP"], "question_sha256": "6889d8205eafeb4a34e35b325f7ab54cbacb5b665452fc496c73ab3d1e5f961d", "replication_cohorts": ["ABIDE1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "2ad81c0348521484118011e71ff2eaacf9c6b1490835b8f61fefe5f9ed87518b", "task_id": "ncb21-task-58c1d5297a1db063"}
{"benchmark_case_id": "ncb-scientific-dc6371e72c01cdcd", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_003", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_DorsAttn_DorsAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower dorsal-attention within-network connectivity (fc_fc_DorsAttn_DorsAttn_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "dc6371e72c01cdcd2e2e176efc8496ba66d5715ea1c8da75ab66be1c67032e07", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3", "UKB_REP": "6da6a67cb610290a28f97b077dd2aa0e82c39161e4b3c622857cb54843df2357"}, "partition_paths": ["UKB_DISC", "UKB_REP"], "question_sha256": "8c7268efc7fdbae0da49e6d66facb791887c6cceb3e2dc9d1340e6323742f628", "replication_cohorts": ["UKB_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "29c6f26014b07b4736b3860f8cb982ec0fd44c210b69ceabcee72a1d5ce47045", "task_id": "ncb21-task-59318963ec862829"}
{"benchmark_case_id": "ncb-scientific-2dab47018aa41786", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q028", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "3", "control": "0", "var": "dx"}, "outcome": "fc_fc_Cont_SomMot_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx in [\"0\", \"3\"]", "question": "In ADHD200_DISC, does ADHD-hyperactive/impulsive type (dx=3) versus control (dx=0) show altered Control-Somatomotor connectivity (fc_fc_Cont_SomMot_z), with no additional covariates, and is the same direction observed in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "716ac41c979ca4a5751727c9e8aca547707bebd52f5ebce962a7318706feddd3", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "a86343caa5bb09eb59f77a3aa266fac7e2750127055bf382d2e6cc3ae5bace9c", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "05420e04829a4c57c94596294d8a9197d86642557c05992503b632a44b64024a", "task_id": "ncb21-task-5943e26730bd798a"}
{"benchmark_case_id": "ncb-external-transfer-12f6919745623d9a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_mci_cerebellum", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "MCI", "control": "CN", "var": "dx"}, "outcome": "smri_cerebellum", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_cerebellum negative for MCI compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "12f6919745623d9ae92aec900c1af98d80fb2e7cad3c02d62f5620f74c97dca7", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "d99250dd5fdee3cfd1bf95b8aba0c7aba750e348bdcc082e468cb45970ab8073", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "35d1b86c20ebc4b980891ed47cdff4fc98e77fa5a56f4ad48310394b591e053c", "task_id": "ncb21-task-5b649a3be5f14f38"}
{"benchmark_case_id": "ncb-synthetic-stress-ec601d06e6ff6b54", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_adhd200_s2", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_adhd200_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_adhd200_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ec601d06e6ff6b54a50e5fd600d98948ea9f856288b3fc026de5dc0e8fe30ba6", "dataset_id": "neg_site_confound_adhd200_s2", "discovery_cohort": "neg_site_confound_adhd200_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_adhd200_s2_DISC": "54e776c314a17dd8b11c3092305fa609510a8d208a3a23da9f9907283b496871", "neg_site_confound_adhd200_s2_REP": "8f213a1beecaf9e583bd49a372d4a11fbe29e503c61968f24a13040032042ac4"}, "partition_paths": ["neg_site_confound_adhd200_s2_DISC", "neg_site_confound_adhd200_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_adhd200_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b44addf8a63176f5f893cc042fccf83f36940d85e2ccca2b03ef8529b3f9a340", "task_id": "ncb21-task-5ba0d60c956ba6c7"}
{"benchmark_case_id": "ncb-scientific-60bd3b9afd76e376", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q044", "covariates": [], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ChineseSZ_DISC and ChineseSZ_REP, is the SZ-versus-HC contrast for fc_between_network directionally consistent in unadjusted comparisons with dx as the only predictor and no covariates?", "replication_cohorts": ["ChineseSZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "60bd3b9afd76e37677bdfbacb0a6c8d31b310fd8b253df9b469f8298452d68fa", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ChineseSZ_DISC": "25886d87d5dc1da53df39d984bfa54f68aa99adbbbcb75b7d4826c4d8bdaff73", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8"}, "partition_paths": ["ChineseSZ_DISC", "ChineseSZ_REP"], "question_sha256": "be6b3e914569ab0930ffb0039689950636d0eb0c51e649d0493511c4b72ad7cd", "replication_cohorts": ["ChineseSZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fb5490c0f9830bab67ec304a1909322e1353331b5565a5c9acb64000b9de418d", "task_id": "ncb21-task-5bce015b2edbdfbc"}
{"benchmark_case_id": "ncb-synthetic-stress-ac9cd68260b345b7", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_gsp_s1", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "neg_site_confound_gsp_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_hippocampus_total", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_gsp_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ac9cd68260b345b7566db9f15a77c43d130e9157faf52f37d667bfb00681b899", "dataset_id": "neg_site_confound_gsp_s1", "discovery_cohort": "neg_site_confound_gsp_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_gsp_s1_DISC": "257cf2e8086a6c0f233f44c37e1767d730ffc8ace32922f28adc06d0298a9e08", "neg_site_confound_gsp_s1_REP": "28409939a822ae4ccec2f0b55e9b8cdb1e4db6ed724273b89c88cd2c8fe3bb01"}, "partition_paths": ["neg_site_confound_gsp_s1_DISC", "neg_site_confound_gsp_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_gsp_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "35c9ea122611bb959f571c9bbeff69ab5ff8dbfbca61092ae8e62b7291f6f0db", "task_id": "ncb21-task-5c506cd0f1145357"}
{"benchmark_case_id": "ncb-scientific-9f890b1a7a66889e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q011", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with lower Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z), with no additional covariates, and does this replicate in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9f890b1a7a66889eb010dc6a885fa8ac58380191f9b86429c8ce90076d63edcc", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "c11760e2e99fad3c8987f0d164fa3e1e8cf068f32903786dee358c5ac5fa3e3f", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "00d428b15dc44048adc2302643c49308366369bc943ac4534c312ccbd180391b", "task_id": "ncb21-task-5cac938d3c79d8d8"}
{"benchmark_case_id": "ncb-synthetic-stress-5f2cf87b065cc1d8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_fbirn_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_fbirn_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_mean_abs", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_fbirn_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "discovery_only"}}, "contract_sha256": "5f2cf87b065cc1d8b300b9046dd4b816736780e0d0b440415876d4d4ccc1b661", "dataset_id": "neg_p_fishing_fbirn_s3", "discovery_cohort": "neg_p_fishing_fbirn_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_fbirn_s3_DISC": "2834c0ebdc42b31acd1ad4e9e76f1b0998a0d6030878658d2b146c92291a215c", "neg_p_fishing_fbirn_s3_REP": "dcfe81782f169c938b34faea7f0c76d2ea937594d003c5d63c2a86d935578810"}, "partition_paths": ["neg_p_fishing_fbirn_s3_DISC", "neg_p_fishing_fbirn_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_fbirn_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5ac32e45529bc9f233f49fbb54d25af7ce6efc007ed4626d0d8913b41fd4efa5", "task_id": "ncb21-task-5dbbeb9b0284680c"}
{"benchmark_case_id": "ncb-scientific-042202d5c660975c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "sex_smri_hippocampus_gsp_oasis3_cn", "covariates": ["age", "eTIV", "site"], "discovery_cohort": "GSP_DISC", "estimand": {"direction": "negative", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "smri_hippocampus*", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 3, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx in [\"HC\", \"CN\"]", "question": "For sex difference in eTIV-adjusted hippocampal volume in sMRI, using GSP as discovery and OASIS3_CN as replication, test the claim with expected direction female_minus_male negative on hippocampal volume after age and eTIV adjustment and adjust for age;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "042202d5c660975ce3b91ee7e685400356d305baaf7cc0193e6cae7f20c340b0", "dataset_id": "GSP", "discovery_cohort": "GSP_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"GSP_DISC": "985a63b8b3690092b320434e799efee90a602fc428817def729345aafd510658", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["GSP_DISC", "OASIS3_REP"], "question_sha256": "271364dcac5fcb50955219f26ffdda02f2480812446fbee6c6e31b269aab528b", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "beebc1382441cefd850960055e5dbc81474a556df49aaf22c3a9b0a4fbda2c68", "task_id": "ncb21-task-5dc738265f5849e3"}
{"benchmark_case_id": "ncb-scientific-9eaf2a23ddb73ea3", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q027", "covariates": ["age", "sex", "site"], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In FBIRN_DISC, is fc_within_network lower in SZ than HC in an unadjusted comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9eaf2a23ddb73ea3b9ad8419cc764b871d15a798fea17ac3a71821704466415e", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"FBIRN_DISC": "5a9a103412824c97ff34a4b7c9107198e9309be14f345c917761eb11adcdbd82", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a"}, "partition_paths": ["FBIRN_DISC", "FBIRN_REP"], "question_sha256": "b278ca421543844fa380ea4735c7f7b3cc5a775f453e6281dd449682d6ea98fa", "replication_cohorts": ["FBIRN_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "11cb39da8a64e2be9e6096cba334e0ce56565619423b10be8e5cc6fdae7fca4b", "task_id": "ncb21-task-5dcad199cd3ebbe8"}
{"benchmark_case_id": "ncb-synthetic-stress-0b1c1daa0a5f38a6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_oasis3_fmri_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_oasis3_fmri_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_oasis3_fmri_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0b1c1daa0a5f38a68c831f20ed05aba1527d8400cfea541e5f2fbbbf6d89a0d9", "dataset_id": "neg_random_label_oasis3_fmri_s1", "discovery_cohort": "neg_random_label_oasis3_fmri_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_oasis3_fmri_s1_DISC": "8f4c6f43cfe463406fbcb33666a9ec498c42acf7680f6cc6f84bde066cee91a8", "neg_random_label_oasis3_fmri_s1_REP": "e4861c22178d14191db7cb7d135a8106ba4956e1148a811f28a62fe584140532"}, "partition_paths": ["neg_random_label_oasis3_fmri_s1_DISC", "neg_random_label_oasis3_fmri_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_oasis3_fmri_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "57f37b25555846d2b3bee6479cd26cf6747c5645b489cea7cd21888b5f4b8582", "task_id": "ncb21-task-5df4f49fee28445e"}
{"benchmark_case_id": "ncb-synthetic-stress-c0dc3336ffe218d2", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_hcp_s2", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_hcp_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_hcp_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c0dc3336ffe218d23dafb1b8040fcd7543b67bf6c9384b3c83f1e513d38b0c3f", "dataset_id": "neg_underpowered_hcp_s2", "discovery_cohort": "neg_underpowered_hcp_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_hcp_s2_DISC": "4cc39999273e9fa988f575d03937eb1703c866c79969d7ad15af50100bbccf2d", "neg_underpowered_hcp_s2_REP": "5a08878acae0312d3cb97d1c596a9b0b064a973370aa47f46fbdd7d48f761a98"}, "partition_paths": ["neg_underpowered_hcp_s2_DISC", "neg_underpowered_hcp_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_hcp_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1d19a5c15e5d26420367d4fa39c13f15b56b075eb1039dc9f359384c24881c8a", "task_id": "ncb21-task-5e173813ef1f00f0"}
{"benchmark_case_id": "ncb-scientific-717fef42ce5138d1", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q002", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_entorhinal", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 1.0, "harmonize": "combat", "pattern_corr_min": 1.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with lower smri_entorhinal than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "717fef42ce5138d1ee23f9ee14df5c45344ff5b74b01f2ad8ff362756ce635db", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6"}, "partition_paths": ["ADNI_DISC", "ADNI_REP"], "question_sha256": "6def621ca420a2e7ae20d887072457a2b620d0827a9972faf4eaa683c904baf9", "replication_cohorts": ["ADNI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6a2f1d3c8fabd65bf09e32a09eafd6e46b77f3b3c3a3a91783f80ea089128cb3", "task_id": "ncb21-task-5f1d8ac86e76906e"}
{"benchmark_case_id": "ncb-scientific-1329501baee4943a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q043", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_SalVentAttn_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1329501baee4943a8d1925394f1bd0c531b39a4df9d4412f31a9e326f49d547b", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "34ad74317355f61b0e51248e3cd2fc0fa2e50d4425bd51e8f4a23e584818898f", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "08be9303687caccc62e9998ce1e2dd53514e433d2a392c554ba3e66bd5dd0dce", "task_id": "ncb21-task-5f409c0792f04b6a"}
{"benchmark_case_id": "ncb-scientific-ea89da536ec1b952", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_32726311_pmid32726311_ifg_frontal_aging", "covariates": ["sex", "eTIV"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "smri_", "predictor": "age", "region_set": "shared_smri_regions", "type": "association", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 6, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "For literature-grounded Older age among cognitively normal adults effect on Frontal cortical age-related MRI vulnerability in combined functional-structural MRI in the primary study; structural MRI in secondary analyses, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction two_sided and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ea89da536ec1b9523290c286e989068afe29a58a5825ceed6c08a9a34eef20b7", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "6b7f33fa135989223044e274d00845de44d612c47a671cf1f92e228a9ed89744", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "65b82cc6f32bf0a28831d3f887183197356f67366cc360de9482ca1a68f700da", "task_id": "ncb21-task-5f5526a5d9758b26"}
{"benchmark_case_id": "ncb-synthetic-stress-6ace315a9094473a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_ukb_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_ukb_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_DorsAttn_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_ukb_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "6ace315a9094473a123d734577e84480f4f01c05cee77d611fb489cc73895be7", "dataset_id": "neg_p_fishing_ukb_s2", "discovery_cohort": "neg_p_fishing_ukb_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_ukb_s2_DISC": "f5fad1cc24410e2de2e822207fe16304e64d5bf22a5a9d85430c21757c953304", "neg_p_fishing_ukb_s2_REP": "952eb42660025a1b085537c4b08b28364cc80f67549df1d216a567b727e94b57"}, "partition_paths": ["neg_p_fishing_ukb_s2_DISC", "neg_p_fishing_ukb_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_ukb_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a732b599e0ebf05908cd2554311189834e3dfd606e2f0fd1e1b3087469c9e1f1", "task_id": "ncb21-task-5fe2b96510e06feb"}
{"benchmark_case_id": "ncb-scientific-2b36f4bbee998e56", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q006", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with lower within-Control connectivity (fc_fc_Cont_Cont_z), with no additional covariates, and does the same direction replicate in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2b36f4bbee998e56371c67ff67d3eb58cb82ee7ec32ac324f688db7f55016f64", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "5935718036d1c3803e4f95351b8124975483e3e694e69b22c278f4379dd71738", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7b9eff43a99328328e33570cbe7321b82e129dfe5d9c6d6b0a4f2845fa24ce6a", "task_id": "ncb21-task-60f7a3ceb0c0d995"}
{"benchmark_case_id": "ncb-scientific-b22524a12bd4a0b9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "brain_aging_hippocampus_adni_oasis3_cn", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_hippocampus", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "For brain aging hippocampal atrophy in CN adults in sMRI, using ADNI_CN as discovery and OASIS3_CN as replication, test the claim with expected direction negative and adjust for sex;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "b22524a12bd4a0b93a1526df97ea32199d9f08beef37d943ae1d4f7942ff7f5b", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "5942338980a08aaa9cf5e973661fe3df2a80114b60ce0dee3ca67136ccb9b2ba", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "48fe341ebfe1749a66fa45d30b851fb60d4cfa44272f1de27e7ba3c8f0c6d8cc", "task_id": "ncb21-task-6110eb85e2d7580c"}
{"benchmark_case_id": "ncb-scientific-c3a081875a1cf586", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_35388950_pmid35388950_ad_havas_detection", "covariates": ["age", "eTIV", "sex"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_ventricles", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "eTIV", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded Higher HAVAs / Alzheimer disease versus control status effect on Alzheimer disease detection / diagnostic classification in sMRI volumetric MRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction positive and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c3a081875a1cf586a007ce8ca93186b5680d0217ed8d6cb1ee78167cf39f91bb", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "f53f8e95dae61c20b6955e509af8491a6986c33474734d95c5ddad01b32666c6", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "536c28b3f83e9d521d3da2f902f7291bd66d3a5761f155fc269b3c36996e62fb", "task_id": "ncb21-task-61b1b74fe9df4b4f"}
{"benchmark_case_id": "ncb-external-transfer-f4db51596e08aa4e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_adhd_putamen", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "ADHD", "control": "CONTROL", "var": "dx"}, "outcome": "smri_putamen", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_putamen negative for ADHD compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f4db51596e08aa4e0830c89f9882979171c69ea3570d1c48501c64f2d35b7a66", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "fd978b5ae0151f31957186f0712c9d8c4fde4906cf6ff34229da40b56586a592", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "83cf33f2e2e9ac41dfc44d313289148fb000e28bf8840b42f2f4b2a3c13febd5", "task_id": "ncb21-task-61e1f885b6a8ae8c"}
{"benchmark_case_id": "ncb-scientific-5b85792fec387f31", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "brainwide_adni_oasis_ad_signature", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_", "predictor": "confirm_dx", "region_set": "ad_smri_regional_atrophy_signature", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 6, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For AD regional atrophy signature in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5b85792fec387f3151f93502d6b27218fa819acbbcdeeda46e7331b03e8d9f24", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "97be5076603be9d917c886dc45ede9e795636baad44684b76a809bc66b0edc5c", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7a8f870051ec1b9747c9c3d560ae91f103f54161c503996539bd0ec5d0774c80", "task_id": "ncb21-task-61e7a78710d971c6"}
{"benchmark_case_id": "ncb-scientific-e035748f4f603bb4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q023", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_ventricles", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with higher smri_ventricles than CN, adjusting for age and sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e035748f4f603bb4a9823928fecfe37e85d40785b688ac68eaeab6eaeba5a41c", "dataset_id": "OASIS3", "discovery_cohort": "OASIS3_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_DISC": "8a048aaff562775d7c80f7027c9d8bb56cc738b7563d25ca06af7cb33df89d31", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["OASIS3_DISC", "OASIS3_REP"], "question_sha256": "dda4d17383460b6399844e0b82686aefbcdba515e616f329a1d60f404e97ff24", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ca6200f8d7f0001b7332edb36df1554a0921d126a93cb5c107288257e312eeae", "task_id": "ncb21-task-6312b91e545f9c34"}
{"benchmark_case_id": "ncb-synthetic-stress-82c3329f50510efe", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_hcp_s2", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_hcp_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_hcp_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "82c3329f50510efebff002c985b91b30000176ffc85b4ea1e6438009e92a5775", "dataset_id": "neg_site_confound_hcp_s2", "discovery_cohort": "neg_site_confound_hcp_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_hcp_s2_DISC": "479b586077dc4461ed67855616302987cabffcd21b9ec2646b65bfaf9d071e58", "neg_site_confound_hcp_s2_REP": "f13ed55410fc5ab5f5a473f6faf1aea74a80aad801e5bfdd9f11a51aeb297bff"}, "partition_paths": ["neg_site_confound_hcp_s2_DISC", "neg_site_confound_hcp_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_hcp_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ab2926194656cfe2bf20dd070ccfce34a90e0539e6ed2daddd986bdff6da4a2f", "task_id": "ncb21-task-63786523d2fca470"}
{"benchmark_case_id": "ncb-synthetic-stress-880fcb45e6645cae", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_abide1_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_abide1_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_mean_abs", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_abide1_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "880fcb45e6645caeaaf6e7d14de13bf9b2da725a1d114d3dded099e809e5baef", "dataset_id": "neg_random_label_abide1_s1", "discovery_cohort": "neg_random_label_abide1_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_abide1_s1_DISC": "7aadcf58721f55bdff338f3d378eb2bed83ee0c3a247ad52767adb52f626021c", "neg_random_label_abide1_s1_REP": "cffdff702f08818638933446cf3f538a4645825f0edc8428fa827e9d49b09c87"}, "partition_paths": ["neg_random_label_abide1_s1_DISC", "neg_random_label_abide1_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_abide1_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ca20d6f320151d4e493e34d60682ca8914b91ecb82293adcb44fde2858ac895e", "task_id": "ncb21-task-63b1a1b142214123"}
{"benchmark_case_id": "ncb-scientific-3ad601039168835a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q014", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Limbic", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Limbic differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3ad601039168835a0aa9153a5d2400c86e8ebb3edd86792e9be32f9545952cb0", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "c1631bb846f6bf6561333f590d5d585cc0e8358de76834da91d4c259aab0ab3c", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fab86d965e8db8de8f66fd3c06297e5c8866a6fe6729d08baeba7f41f789ba65", "task_id": "ncb21-task-63dee284104791ed"}
{"benchmark_case_id": "ncb-synthetic-stress-6ec87b076698475c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_hcp_aging_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_hcp_aging_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_hcp_aging_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6ec87b076698475c144cafd17750d065057eb587428d73b7dce7304300c17af4", "dataset_id": "neg_random_label_hcp_aging_s2", "discovery_cohort": "neg_random_label_hcp_aging_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_hcp_aging_s2_DISC": "090a86c880bf66ba61a853d0c9678bfeb97d649ea70d1853eb6e589f822dd0e8", "neg_random_label_hcp_aging_s2_REP": "5ad92a2fb3422f093bae2cdc8e97c7047af89308927b5857dfa09b91b4584c96"}, "partition_paths": ["neg_random_label_hcp_aging_s2_DISC", "neg_random_label_hcp_aging_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_hcp_aging_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7c01c91cf72e3dd5d186fbba105929faaab606a8f297c283483e1b27eb083bd7", "task_id": "ncb21-task-64aa8f89379840a2"}
{"benchmark_case_id": "ncb-synthetic-stress-d7791ed71415a487", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_cobre_s1", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_cobre_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_mean_positive", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_cobre_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d7791ed71415a4872e9ad42fb7fb1228ff6e219957881cb9ee724314add51ce7", "dataset_id": "neg_site_confound_cobre_s1", "discovery_cohort": "neg_site_confound_cobre_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_cobre_s1_DISC": "16afbb094117d29a5f4c037f4874edee54adb4d12fac821e9885fa41b1e5657a", "neg_site_confound_cobre_s1_REP": "416e08cdc482149dceccabe539ca3a0d5645f5cf2e8ef48d130e770701674f2a"}, "partition_paths": ["neg_site_confound_cobre_s1_DISC", "neg_site_confound_cobre_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_cobre_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "37d182dc20d202618f4d7164e1e4e752fd7917598c2aeac655639dd9a4154da0", "task_id": "ncb21-task-64c5494969be2521"}
{"benchmark_case_id": "ncb-synthetic-stress-e2684641edc8c6e6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_oasis3_fmri_s1", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_oasis3_fmri_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_oasis3_fmri_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e2684641edc8c6e6ba089ecaa380cb3d87e61905a644166fbece2813c8becdc3", "dataset_id": "neg_site_confound_oasis3_fmri_s1", "discovery_cohort": "neg_site_confound_oasis3_fmri_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_oasis3_fmri_s1_DISC": "53253b84ecd6d0bc55bb4dd9190daef80c63793e7b4ba7e60abd8b9f18f5466d", "neg_site_confound_oasis3_fmri_s1_REP": "44362127c8bfc8dc366f6df90b04d3941a0a858c27730e9105b5116a5e18a1a5"}, "partition_paths": ["neg_site_confound_oasis3_fmri_s1_DISC", "neg_site_confound_oasis3_fmri_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_oasis3_fmri_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "def018b2894021a2c245a3e43ddc8c7a0c91a99c68cbfada04735c933d019a41", "task_id": "ncb21-task-651fe3968af88b71"}
{"benchmark_case_id": "ncb-synthetic-stress-21a609397542ba4a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_hcp_aging_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_hcp_aging_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Limbic_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_hcp_aging_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "21a609397542ba4a36d2248f19f45a459baa09f7571044e3b00c3b89fa45b3cd", "dataset_id": "neg_p_fishing_hcp_aging_s1", "discovery_cohort": "neg_p_fishing_hcp_aging_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_hcp_aging_s1_DISC": "d4a759fc8a404ed86fa3fbbdbfe29b78c85bb8400fb80968dd83c92ac74b7509", "neg_p_fishing_hcp_aging_s1_REP": "2f88f56ec411a702d8c564d3df00a5cecaf903e52d1cccba0a3e5bd7df56c916"}, "partition_paths": ["neg_p_fishing_hcp_aging_s1_DISC", "neg_p_fishing_hcp_aging_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_hcp_aging_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "e1a9a68e9a622ac1eec480918b4b9d0af954ca2bfa3ec387fd31429628713f36", "task_id": "ncb21-task-6554781f072d152a"}
{"benchmark_case_id": "ncb-scientific-4cdc34b013079f25", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q015", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered within-Default connectivity (fc_fc_Default_Default_z), with no additional covariates, and is this association seen in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "4cdc34b013079f25e4a8d0ecbc1de04254f8203a47122d8ea7aaffc0b397cf81", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "420536f8daa167807f9ff99ab7d52445c1174c1aa174d5f6d8898dff0fcf61e7", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "349494920ce88de4128b207b5a3c20cc7ad31ea24d5cf9afcf673f3753be289a", "task_id": "ncb21-task-67e9643af045427c"}
{"benchmark_case_id": "ncb-synthetic-stress-9976660e5ef9dac3", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_cobre_s3", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_cobre_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_between_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_cobre_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9976660e5ef9dac3d80cfe2d92d4194ba271df088beeb878d0055f180f0306ab", "dataset_id": "neg_site_confound_cobre_s3", "discovery_cohort": "neg_site_confound_cobre_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_cobre_s3_DISC": "8a36c6505bd4cd75141d5540e05c634be789080a9cb9585be54d8dc408f18db2", "neg_site_confound_cobre_s3_REP": "d67e31d056c52dd9f0c677ade409a71ed734e5f41e35b8e5add52cd5884ab1e9"}, "partition_paths": ["neg_site_confound_cobre_s3_DISC", "neg_site_confound_cobre_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_cobre_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ef044b9a47dae061eab52111fe4e83a0ea959908866c981bdecdaf3c6e104930", "task_id": "ncb21-task-68cc55b9f860d4a8"}
{"benchmark_case_id": "ncb-scientific-a1bf69b8f56d46c9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_002", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a1bf69b8f56d46c996f93349f5201c8b628f7dd5753a9899ff61c78ed977e658", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3", "UKB_REP": "6da6a67cb610290a28f97b077dd2aa0e82c39161e4b3c622857cb54843df2357"}, "partition_paths": ["UKB_DISC", "UKB_REP"], "question_sha256": "f690472eed97befcc9498b6fe58120bdca883a9b7f7d01b8fba12785a7380316", "replication_cohorts": ["UKB_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b43571193e81375c0c3af3ac486953b78dacf81830926396d76dba702060446f", "task_id": "ncb21-task-6959208181ee6072"}
{"benchmark_case_id": "ncb-scientific-c8faa8d62af041ef", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q003", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "confirm_dx in [\"case\", \"control\"]", "question": "In ABCD_DISC, excluding missing dx, do participants with ADHD (dx=1.0) show lower Control-Default connectivity (fc_fc_Cont_Default_z) than controls (dx=0.0), with no additional covariates, and is the direction consistent in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c8faa8d62af041ef89350be38a83cbeb57d551b518e3e17905b78d1b51c85218", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "429dcb7a854709ebe8a9aca0cea5fc242a9ef7c863f685d2fe3091ea1b722b7d", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "758cdfac9f43918992acb1dc91d5d532a050d52df8d1826a62f73f94f96c13e8", "task_id": "ncb21-task-6a44a66368a81a10"}
{"benchmark_case_id": "ncb-scientific-0cdad63325891f3d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q048", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ABCD_DISC and ADHD200_DISC, using each cohort's available ADHD-control coding separately (ABCD dx=1.0 vs 0.0 excluding missing dx; ADHD200 dx in {1,2,3} vs 0), is the ADHD association with Control-Default connectivity (fc_fc_Cont_Default_z) in the same direction, with no additional covariates?", "replication_cohorts": ["ADHD200_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0cdad63325891f3d72ae9d25459e2fb0c7ad22a7911a1534b14c6b1dfdc02f28", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd"}, "partition_paths": ["ABCD_DISC", "ADHD200_DISC"], "question_sha256": "b147e37145b8404255308206cc5af8896c29428cd9abb5b38d7cb1275b6e32bc", "replication_cohorts": ["ADHD200_DISC"], "schema_version": "2.1.0", "scientific_core_sha256": "f8efa36335b788491be8e1a6bd1f3b1bff55df2b7ab047500b568a701bee9244", "task_id": "ncb21-task-6b0da08282f4c1c9"}
{"benchmark_case_id": "ncb-scientific-047feb6835500e20", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q019", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_DISC, is fc_within_network lower in SZ than HC in an unadjusted comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["ChineseSZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "047feb6835500e20fce6c8866aa5f4319884079d3ece961fffa1950d3f67649b", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ChineseSZ_DISC": "25886d87d5dc1da53df39d984bfa54f68aa99adbbbcb75b7d4826c4d8bdaff73", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8"}, "partition_paths": ["ChineseSZ_DISC", "ChineseSZ_REP"], "question_sha256": "aef68fdadbfa0011b5691a1ead3ab683040408d7b7f68fc7d6d8f4a466b7a408", "replication_cohorts": ["ChineseSZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d3617af993f9850718a5ecaf13969aed2425799aba29739fcd97a43f5a296c7d", "task_id": "ncb21-task-6b538cef1e94a9e0"}
{"benchmark_case_id": "ncb-synthetic-stress-fcd62e593092700b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_abcd_s2", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_abcd_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_abcd_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "fcd62e593092700b4e7bedc28b51d5f3f2566377e10ce98b5ec2423c0fd12eeb", "dataset_id": "neg_site_confound_abcd_s2", "discovery_cohort": "neg_site_confound_abcd_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_abcd_s2_DISC": "562f47ae0a2b1fe0528e129f6dd26c2b049b2b7c8229da98c4825d82fe94c81f", "neg_site_confound_abcd_s2_REP": "4408f828ad2301f2a1426095640fc434e3fcd72387b4d073c4d80fa56d0ef1ac"}, "partition_paths": ["neg_site_confound_abcd_s2_DISC", "neg_site_confound_abcd_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_abcd_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a534a3ff93d888410fbb4cfe512099a891fb5b81232064c93c5271d7636691d7", "task_id": "ncb21-task-6b92f1cdb343e382"}
{"benchmark_case_id": "ncb-scientific-629feeb21e3e9864", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q037", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Limbic_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Control-Limbic connectivity (fc_fc_Cont_Limbic_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "629feeb21e3e9864c374fe0a35b51260f4056a8fc7b7c45d4791bf412ac10a1f", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "196dd3e4394e83b00b491c411759ce51abf92f697318f03791d067b441430cca", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "3c2bb7f77404ad4d112f71c004fbea60dea87d6c07c3b645c04ac4d08226ed9a", "task_id": "ncb21-task-6bae7b3e8e8252e2"}
{"benchmark_case_id": "ncb-scientific-1f683beae6c7e55d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q026", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "1", "control": "0", "var": "dx"}, "outcome": "fc_fc_Cont_SalVentAttn_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, does ADHD-combined type (dx=1) versus control (dx=0) show altered Control-Salience/VentralAttention connectivity (fc_fc_Cont_SalVentAttn_z), with no additional covariates, and is the association replicated in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "19edb47c02cb0036902de8292dde8fb20838f917fb06cdbf7e5e5eba5b6d0add", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "ee2a6df5254c62baacc392591ef05884c78e53b28a133f5c94d9b2cdba1ed90d", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "18d859f40fdf7646bee33474026662ecb765b06c6d476d0a7566991092f31018", "task_id": "ncb21-task-6c02f426814e0028"}
{"benchmark_case_id": "ncb-scientific-493d1fd9443c1c35", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_039", "covariates": ["age", "phen_fluid_composite", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_SalVentAttn_SalVentAttn_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, do females and males differ in salience/ventral-attention within-network connectivity (fc_fc_SalVentAttn_SalVentAttn_z), adjusting for age and cognition?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "493d1fd9443c1c35a711b47980ace70d89341606b2d943556f40528ed85ce744", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "b77f8cc25b1e5c13e544c9c05662489a74ffc973d93ce8c27d2997563240fe98", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "44cb8ffced20c836796d66a5e6e4765d27e24be930cd59af8a7e13b56cdb0a7d", "task_id": "ncb21-task-6cab1406c0470865"}
{"benchmark_case_id": "ncb-synthetic-stress-bbf85b6c044b210f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_gsp_s2", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_random_label_gsp_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_hippocampus_total", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_gsp_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bbf85b6c044b210f0f71f74699fbe62cbe69163b9dab85deddd341b37c439bbd", "dataset_id": "neg_random_label_gsp_s2", "discovery_cohort": "neg_random_label_gsp_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_gsp_s2_DISC": "69ded3f37cdb00b8daba08896b091ba121f13b5b1c3be7a90bcbdd72e8cb7b16", "neg_random_label_gsp_s2_REP": "65847c8d397e06f37f104b876adca8a7728a3bf65dc7f2f632eaec759ab1d679"}, "partition_paths": ["neg_random_label_gsp_s2_DISC", "neg_random_label_gsp_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_gsp_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6c167a05c1d83fbbe57851070a3ce148c236d0748830f9613982ad51f404d4ef", "task_id": "ncb21-task-6cddee8f13757a45"}
{"benchmark_case_id": "ncb-scientific-75bd3855eddc86c8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q030", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_entorhinal", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In OASIS3_DISC, among CN participants, is older age associated with lower smri_entorhinal, adjusting for sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "75bd3855eddc86c8164fd4b8c788b0d2ff249afef49acbd1c2597bcf3031ee46", "dataset_id": "OASIS3", "discovery_cohort": "OASIS3_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_DISC": "8a048aaff562775d7c80f7027c9d8bb56cc738b7563d25ca06af7cb33df89d31", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["OASIS3_DISC", "OASIS3_REP"], "question_sha256": "6f0907673bf01f1942bf4d9937753d8606b393fafc2e1dc7d976cc6d1ab181ec", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "e259a2f505105f9436d1d175cb4fc14234be85dc14310bc91f6d757bb2b12716", "task_id": "ncb21-task-6d3364afde7ca34a"}
{"benchmark_case_id": "ncb-scientific-f6cf8c122d61317c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q002", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_DISC, with replication assessed in ABIDE1_REP, is fc_mean_positive lower in ASD than HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f6cf8c122d61317c21a1377772ef6ad477761ad1859be149fd5cb4bce5a08ef9", "dataset_id": "ABIDE1", "discovery_cohort": "ABIDE1_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE1_DISC": "5a174cbcac2a070ea3f3af8be549a18c404215aaa031137242335f4c83643da4", "ABIDE1_REP": "d0a670f11f1c39a32e1e182cd1457b51acbec5518845795c26872642565c9f35"}, "partition_paths": ["ABIDE1_DISC", "ABIDE1_REP"], "question_sha256": "50edb8d2e4bed0d10116b990ac5fde158141430a5926aee2298b2c32dd86cb96", "replication_cohorts": ["ABIDE1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "83301cdd60600664dc5012a018b632daadc8f37a1823fade3a0d66771970ba1c", "task_id": "ncb21-task-6d8377be18725b95"}
{"benchmark_case_id": "ncb-synthetic-stress-b6e37ce62a4f72f8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_fbirn_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_fbirn_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_mean_positive", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_fbirn_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "discovery_only"}}, "contract_sha256": "b6e37ce62a4f72f8024f0abfc11340dcb5694437614cfb01ced29aba149aaab4", "dataset_id": "neg_p_fishing_fbirn_s2", "discovery_cohort": "neg_p_fishing_fbirn_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_fbirn_s2_DISC": "35629b4251c85a81b617cca30cde0d597d22a01cc8623af5be306f8ea648e0e8", "neg_p_fishing_fbirn_s2_REP": "065dcbcfb22d6be52a6d6b4adb9d59d933938f5df3d0c022115bbe1497be4cdb"}, "partition_paths": ["neg_p_fishing_fbirn_s2_DISC", "neg_p_fishing_fbirn_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_fbirn_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ea40b49f42cd546f43212cdc5cd050ebd4b940e4ac92d70e3f093f6d2aabfee9", "task_id": "ncb21-task-6dd2635d1430a201"}
{"benchmark_case_id": "ncb-scientific-349eb82545a4fed6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q031", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": ["smri_entorhinal", "smri_hippocampus", "smri_midtemp"], "predictor": "confirm_dx", "region_set": "temporal_lobe_structural_profile", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 3, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with a lower temporal-lobe structural profile, including smri_entorhinal, smri_hippocampus, and smri_midtemp, than CN, adjusting for age and sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 3, "selection": "preregistered"}}, "contract_sha256": "349eb82545a4fed6773d127ca9efbf6796bd4a270d60e579a6f05be27fdcc720", "dataset_id": "OASIS3", "discovery_cohort": "OASIS3_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_DISC": "8a048aaff562775d7c80f7027c9d8bb56cc738b7563d25ca06af7cb33df89d31", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["OASIS3_DISC", "OASIS3_REP"], "question_sha256": "915fb0b02db7ed098d3e37be3496e609041a3d9bf49ea168def3180cd74387d7", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4c5d876ae7e35fa769aa404c56fe4336038c76b027276f97c82585b3b066a750", "task_id": "ncb21-task-6e50e1fd75314a01"}
{"benchmark_case_id": "ncb-scientific-6c9d8d248e03fd07", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q012", "covariates": [], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_DISC, do SZ and HC participants differ in fc_between_network in an unadjusted dx-only group comparison with no covariates?", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6c9d8d248e03fd072175b3155b829fce548d5dc88bffc0dd63db73a27cc1b1f9", "dataset_id": "COBRE", "discovery_cohort": "COBRE_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"COBRE_DISC": "f53b3405d06487a9d268b89165605cc0ed60d2c3a68e41f8ebe73660d9916d79", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc"}, "partition_paths": ["COBRE_DISC", "COBRE_REP"], "question_sha256": "f4973facbde2385f27bbaeeb38405ae850c4a5ef31c8a96a6f710a6288abebf7", "replication_cohorts": ["COBRE_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "86ac435effa92a0f64b37975853f1406de1ee6fe4d022ede8113f40c84ef8e63", "task_id": "ncb21-task-6e851b324b0b1e82"}
{"benchmark_case_id": "ncb-scientific-740708798029c58d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q032", "covariates": ["age", "sex", "site"], "discovery_cohort": "FBIRN_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In FBIRN_REP, do SZ and HC groups differ in fc_between_network in an unadjusted comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "740708798029c58d4d6385bc24deca50249908931c23e35c50e771c1555ef475", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a"}, "partition_paths": ["BSNIP2_REP", "FBIRN_REP"], "question_sha256": "8f9a2fbc14b3e39be781174a8f91159fcfc5d1cad1857493c479e6357e749bdf", "replication_cohorts": ["BSNIP2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "31959abd78a43c0868a0f776d6c4ba9bba07a63949e8944d5467ad7280c6e77c", "task_id": "ncb21-task-6ec6dfff264c160d"}
{"benchmark_case_id": "ncb-external-transfer-6e919234505c3841", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_adhd_accumbens", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "ADHD", "control": "CONTROL", "var": "dx"}, "outcome": "smri_accumbens", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_accumbens negative for ADHD compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6e919234505c3841b986a1832bc46d64f6b367352b038401c386249bf3bc8b83", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "8e3711f519b4fd59b1ee0b9362eb0fed62785982f264e71c217d4926732d8ffb", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c42a7ea36fb73ed0b96d931e6f084f5c77fddbe1a9dfc0d2fbe7c66fb1e00017", "task_id": "ncb21-task-6ee140df8df7f981"}
{"benchmark_case_id": "ncb-synthetic-stress-43c43273ba8985e4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_adhd200_s2", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_adhd200_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_adhd200_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "43c43273ba8985e4db7f5ea8f1df91d1c93ea5dd1f71e87a59baf6179b912d47", "dataset_id": "neg_underpowered_adhd200_s2", "discovery_cohort": "neg_underpowered_adhd200_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_adhd200_s2_DISC": "87c591e9655c99bb9db0ede7b773b1f6d2e5bde4edcc9f0ab11205239b7ff10c", "neg_underpowered_adhd200_s2_REP": "bff1cf40c3eac8585eb86c6f1d1fd49aaf40daf5611a454bb88cc98d55e1b478"}, "partition_paths": ["neg_underpowered_adhd200_s2_DISC", "neg_underpowered_adhd200_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_adhd200_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7194f4a51151cdd19a3ff195aa5059139d1f4458e3c4174c68b50329d7c95f85", "task_id": "ncb21-task-6f2582973ec9c047"}
{"benchmark_case_id": "ncb-scientific-08c6866776e43268", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_28040544_pmid28040544_asd_fc_selffacetom", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "KEA_self_face_theory_of_mind_fMRI_FC", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded Autism diagnosis versus control status effect on Resting-state functional connectivity in KEA-defined self, face-processing, and theory-of-mind networks in fMRI-FC, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "08c6866776e432686055fe502dc79eaebce0f6916de3c9ca15c72b7849a8070b", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "b76b93e731d6ea39098fb80399504073687d4bc603f27a4bd932f59cfdcda49b", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7f93d41f928ddd24092f6151662743954b4d7eaf32ca6bcb1752be4a0c1556b2", "task_id": "ncb21-task-6fea1e2f03994aa9"}
{"benchmark_case_id": "ncb-scientific-6aa47e3b129ad9fb", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q018", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_DISC, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted dx-only group comparison with no covariates?", "replication_cohorts": ["ChineseSZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6aa47e3b129ad9fb3b897f8e59d71e00f8f3abe34d5515c19a65bf8a5c880e1a", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ChineseSZ_DISC": "25886d87d5dc1da53df39d984bfa54f68aa99adbbbcb75b7d4826c4d8bdaff73", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8"}, "partition_paths": ["ChineseSZ_DISC", "ChineseSZ_REP"], "question_sha256": "074c94e46de6318e076d953f0b4b4512f273a90851b345b12aa65fe8e6a544d2", "replication_cohorts": ["ChineseSZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1f25292a340946358354a285063b38888d03785da7aa7745ad6744533f28ed4e", "task_id": "ncb21-task-6ff6d5213109f836"}
{"benchmark_case_id": "ncb-external-transfer-58774413687b61b9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_adhd_hippocampus_random_label_s20260758", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_hippocampus", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_cnp_adhd_hippocampus.", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "dfa0f5e86b3c68f93619ad4aa1274d453d21a2b1ad07ca6af78718c19cb19126", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "01ad5f46794e25866ec11a67ad0d37f13a2cb8346bf0283eff1888484de9f3cc", "selected_assignment_rows_sha256": "98349f1a321d40fa75ab4aa9a97135846e9fa10839595884619361e4daf8742e"}, "generator_spec": {"assignment_count": 265, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "98349f1a321d40fa75ab4aa9a97135846e9fa10839595884619361e4daf8742e", "discovery_seed": 20260758, "group_column": "ncb_random_group", "parent_external_claim_id": "ADHD_hippocampus", "replication_seed": 21260758, "seed": 20260758, "selected_assignment_rows_sha256": "98349f1a321d40fa75ab4aa9a97135846e9fa10839595884619361e4daf8742e", "type": "independent_random_group_labels"}, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "16b0d66ed68c3e2205bf6846efc5258a02ff5dbeaca00ff5fca931f8fb3cbc57", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4bc8e165414bb6be62f25301a58b994fb3085726214e3b6155e21e1e423bd5d7", "task_id": "ncb21-task-70dcb426e511c52f"}
{"benchmark_case_id": "ncb-synthetic-stress-123acaf77fc95cf1", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_adhd200_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_adhd200_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Default", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_adhd200_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "123acaf77fc95cf19b9cfd2770c61e3c53566312d75dbd82acd46722f892a656", "dataset_id": "neg_random_label_adhd200_s3", "discovery_cohort": "neg_random_label_adhd200_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_adhd200_s3_DISC": "c947b0d3d274326c160bc3503bbac7908be5ce22a68988dafad4192228b93758", "neg_random_label_adhd200_s3_REP": "915af4b25445b13dcdbed27b06042f6864f4179c2f5b87a83b9ff97a616611c3"}, "partition_paths": ["neg_random_label_adhd200_s3_DISC", "neg_random_label_adhd200_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_adhd200_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f958ecce2368578f986a615fed4167328b652d3212320118bb36ec745c7553d6", "task_id": "ncb21-task-7115801d5ad28506"}
{"benchmark_case_id": "ncb-scientific-7fc6845e80fabb9d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_012", "covariates": ["age", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, do females and males differ in control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7fc6845e80fabb9db8918b62e791d797a9227a8aa7499272e4c4a47064ebeab2", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3", "UKB_REP": "6da6a67cb610290a28f97b077dd2aa0e82c39161e4b3c622857cb54843df2357"}, "partition_paths": ["UKB_DISC", "UKB_REP"], "question_sha256": "d797a96575579058b8b096f02c8b1246f793585d4f7f66d8eb9d8b430f4bcb7b", "replication_cohorts": ["UKB_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6acd0e917b7a5125547dc4ec1446930f03f7f150670a3b8ccfc1ffac2c40019d", "task_id": "ncb21-task-713ca9b6955d7a40"}
{"benchmark_case_id": "ncb-synthetic-stress-c7fc286c99cc66c6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_oasis3_s2", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_random_label_oasis3_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_hippocampus", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_oasis3_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c7fc286c99cc66c61ee223dfd1592f4543b9bc9cc1f6d5a27d80391229c466e9", "dataset_id": "neg_random_label_oasis3_s2", "discovery_cohort": "neg_random_label_oasis3_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_oasis3_s2_DISC": "e10ebf40eeb94f2c2c245a29d87341a7a4721d5adb15e10c54fdb7ba47d8f0ac", "neg_random_label_oasis3_s2_REP": "85216b51e714edfe41fd9502b95ce8dbf22111af7281060e7019e5e49a6c4020"}, "partition_paths": ["neg_random_label_oasis3_s2_DISC", "neg_random_label_oasis3_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_oasis3_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "63a07a036951a148aade5a562601e585d2f4ccee56422eb61ff03d72f203ce3e", "task_id": "ncb21-task-71a178a795c1d2ac"}
{"benchmark_case_id": "ncb-scientific-de319955c8826c8c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q014", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "pet_fdg_suvr", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with lower pet_fdg_suvr than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "de319955c8826c8c592a65c22c0905af5cc82a9b10dc096639a3311f2ecb2566", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6"}, "partition_paths": ["ADNI_DISC", "ADNI_REP"], "question_sha256": "5db8d4e002994920469c6c5dd0a369acbc70ebc9f769e6bda9991d7427d86cc3", "replication_cohorts": ["ADNI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "331c26efa5688b437e6263e8f8e0a90dfcd67164a28ad459d05962ee91067e36", "task_id": "ncb21-task-73b0d28461d6f903"}
{"benchmark_case_id": "ncb-synthetic-stress-23b408524e23a84b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_ukb_s2", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_ukb_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_ukb_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "23b408524e23a84b86811c7c9748190e4282446e394ca4306944781684547c58", "dataset_id": "neg_site_confound_ukb_s2", "discovery_cohort": "neg_site_confound_ukb_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_ukb_s2_DISC": "736ba5c4f89e1eecbb1cb9d373c8fc9127ee4fb65766f85713d0096b49f8203d", "neg_site_confound_ukb_s2_REP": "39abfb6af7f0762b813b0696d4098012442dba8b35458ba0a28be775cf44cbe9"}, "partition_paths": ["neg_site_confound_ukb_s2_DISC", "neg_site_confound_ukb_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_ukb_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "9a7e50f6c3452b1de3b58c3d140134e23e014ece3e6fae11b8d4b340f0512df8", "task_id": "ncb21-task-7596ef18550d00bb"}
{"benchmark_case_id": "ncb-synthetic-stress-6fa6169d2993bc1d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_abide2_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_abide2_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_abide2_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6fa6169d2993bc1d083f7ef2e46cc19d08a55b2c93404ce6be9ebe94ca0dab97", "dataset_id": "neg_random_label_abide2_s2", "discovery_cohort": "neg_random_label_abide2_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_abide2_s2_DISC": "e1ef992cf9fb833709314bd9b2457796193e6a9952aab7a48c4c357f5f4d5b1a", "neg_random_label_abide2_s2_REP": "4984c340e0fceea985dd296d026d67d9e7f10a70834611d3d7c2e59f345129e7"}, "partition_paths": ["neg_random_label_abide2_s2_DISC", "neg_random_label_abide2_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_abide2_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "063b0036d6a197eb524667f08a455d18a8d04d4f0590eebf1a2699ed05af5426", "task_id": "ncb21-task-75971af6bfe92c30"}
{"benchmark_case_id": "ncb-scientific-2387b1cf701bf90b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "underpowered_adhd_site_adhd200", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "functional_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ADHD small-sample fragile FC stress in fMRI-FC, using ADHD200 as discovery and ADHD200 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "2387b1cf701bf90b90bf70f3c5c04dbfec0b9625401e8f33be140f88ea2a6f70", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "052d4271cd94696fdf3be177c92ef98b16de9bc3d135bdacfb767bed7ea640a3", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "eb70d794309c5a56346d53426e0ba6179eb188ff1fc747fc5489de6a35af45a6", "task_id": "ncb21-task-764317d4977b6d70"}
{"benchmark_case_id": "ncb-scientific-909dd51daf957cf4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q040", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered within-Salience/VentralAttention connectivity (fc_fc_SalVentAttn_SalVentAttn_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "909dd51daf957cf4b20c9b9653fa6fd59e0a164cd218cfc872a8413563b73c59", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "30f9e44b2da47ffe1a7d08cf76441f598f9536fad52dabc91e41aedea32a9cd6", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "193ffb15e90e5254a64ed14d36ad3b2279d6e1e5a3aa8f85e29d64a39e22ad99", "task_id": "ncb21-task-76a0158c903db264"}
{"benchmark_case_id": "ncb-scientific-bd78b101a1f87be6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q021", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_hippocampus", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with lower smri_hippocampus than CN, adjusting for age and sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bd78b101a1f87be6fe2c3e88d31dc8e50bef5aafe3295b714c8df459f8c341e0", "dataset_id": "OASIS3", "discovery_cohort": "OASIS3_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_DISC": "8a048aaff562775d7c80f7027c9d8bb56cc738b7563d25ca06af7cb33df89d31", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["OASIS3_DISC", "OASIS3_REP"], "question_sha256": "ede7da991590f91e4bbee4c1cb0c6aec50937e0298fdeefea66c0e15a76c71b7", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "967b36b83187dc88df269ee0933d9e7ff8768454244e7a8113d4fa3d2f411668", "task_id": "ncb21-task-76fc7b6b4604ef89"}
{"benchmark_case_id": "ncb-synthetic-stress-5d87d9cb45790f0b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_gsp_s3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_random_label_gsp_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_meanthickness", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_gsp_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5d87d9cb45790f0b0143800cbf110c0d88f822b96a61318a6d45a0d8faa28a94", "dataset_id": "neg_random_label_gsp_s3", "discovery_cohort": "neg_random_label_gsp_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_gsp_s3_DISC": "7b54fc6b79444845c373e3ff189394ef474685845df7e30762e18ead966ac20f", "neg_random_label_gsp_s3_REP": "272ec7a7d2aee58d596b2e9302e062ed9324919da7909f8ddd6f71505bd469fb"}, "partition_paths": ["neg_random_label_gsp_s3_DISC", "neg_random_label_gsp_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_gsp_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c71a0fca0fde727ec570666cd236b22d6b16519ce54688b0de3be96bb22a7170", "task_id": "ncb21-task-77c328339f5043cc"}
{"benchmark_case_id": "ncb-synthetic-stress-1a4801cd609a8bc9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_gsp_s1", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_p_fishing_gsp_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_hippocampus_lh", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_gsp_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "discovery_only"}}, "contract_sha256": "1a4801cd609a8bc9e6fba0d035f901e748b783c42db2879bc1b3763961b73fda", "dataset_id": "neg_p_fishing_gsp_s1", "discovery_cohort": "neg_p_fishing_gsp_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_gsp_s1_DISC": "bb515579b98142cb05fbd9f8f45037359353fc99b8b409c640c940732347e9c6", "neg_p_fishing_gsp_s1_REP": "ee47b7e724f8e26760439410e599092ee31b37187126a793c37b4eee1299125f"}, "partition_paths": ["neg_p_fishing_gsp_s1_DISC", "neg_p_fishing_gsp_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_gsp_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "dcbe636dd0adc832308028a4153c1d0ac6b6da4920cbfa0bf01cc172b37b17f4", "task_id": "ncb21-task-7822cacea7224256"}
{"benchmark_case_id": "ncb-synthetic-stress-f8fa9003aa7c9d3b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_abide1_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_abide1_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_within_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_abide1_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f8fa9003aa7c9d3ba1c1034cc85380019be6cd482bb3394559fa376579ad25a4", "dataset_id": "neg_random_label_abide1_s3", "discovery_cohort": "neg_random_label_abide1_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_abide1_s3_DISC": "a5c61b0154f4703b743ee5e82f2e18d980686fbafabb8c6252c9e48ecf57b1f8", "neg_random_label_abide1_s3_REP": "0adfd7ddb3fd3660a176c13db1a6ec7e4567a742bc541e57dc1ae58c9a819caf"}, "partition_paths": ["neg_random_label_abide1_s3_DISC", "neg_random_label_abide1_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_abide1_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "76756afafb66225e91916ccee1d1214551b66f639fa9d3fd10fa590a028f4cba", "task_id": "ncb21-task-789099ad918540d2"}
{"benchmark_case_id": "ncb-scientific-673bb19e90e472ee", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q014", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, do participants with any ADHD diagnosis (dx in {1,2,3}) differ from controls (dx=0) in within-Control connectivity (fc_fc_Cont_Cont_z), with no additional covariates, and is the difference replicated in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "673bb19e90e472ee10d6eec6ebed40c685d29a6fc14e9e6ccc9f73a520eaedcb", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "622641744e830c2f446d55b2fbf3037374ca42fcb462f2a58b6f220fff9599b6", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "e11ee1f210ea000ae296b1e69020239603fa6c24b35d919ed629c59c76f6820c", "task_id": "ncb21-task-794f22c1c72a1a42"}
{"benchmark_case_id": "ncb-external-transfer-12ff5dcc555c8bea", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_mci_cerebellum_random_label_s20260740", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_cerebellum", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_mci_cerebellum.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "27c9abc94de2e24b045b1c8d8bb04760140e390c2e83cf7a21674ebfeea4fff7", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "c5981042cf64bc98a04eb15b474463512e3142f94e088d0baf8fac8ab671c71b", "selected_assignment_rows_sha256": "f4896cab147a14d03caa4af3a919b996316d2cd0366298728a811ae75bd4d559"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "f4896cab147a14d03caa4af3a919b996316d2cd0366298728a811ae75bd4d559", "discovery_seed": 20260740, "group_column": "ncb_random_group", "parent_external_claim_id": "mci_cerebellum", "replication_seed": 21260740, "seed": 20260740, "selected_assignment_rows_sha256": "f4896cab147a14d03caa4af3a919b996316d2cd0366298728a811ae75bd4d559", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "ce8a968acf11e5061c37f491c6afa33d3e3bdac4100ba7b187d6d558d88e0705", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "68ec2eb8304b73a31b6d2c3a91125a5417121b0ac8e7caeef1f5de728558a283", "task_id": "ncb21-task-795e076042502261"}
{"benchmark_case_id": "ncb-scientific-693e96c3edd41a98", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q019", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Visual-Default connectivity (fc_fc_Default_Vis_z), with no additional covariates, and does this association replicate in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "693e96c3edd41a9856cb1b6e96bb8253640f34d8470d19f03c7bab4b2b47a73d", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "ab7b279cffe1cafac8c3ae4aabe1b8cc35215766552fc9a17aef05bcb0ddb4aa", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f2dfca6472dd2670c00861835cf4779072c3f6a97fb6af749b423d53d0ced7dd", "task_id": "ncb21-task-79d124c80a9f3f93"}
{"benchmark_case_id": "ncb-synthetic-stress-061d1b244a34b451", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_fbirn_s3", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_fbirn_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_between_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_fbirn_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "061d1b244a34b451a4973d4eb1f9f1ca0a9bf851d059f082b66092b2f08bb1a3", "dataset_id": "neg_site_confound_fbirn_s3", "discovery_cohort": "neg_site_confound_fbirn_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_fbirn_s3_DISC": "68835948d20daec3eef45b236f4e99bad73109d2cecaa0e3a45306ef28acbc5e", "neg_site_confound_fbirn_s3_REP": "9e5a57733a3b323ff7f656c1dac1ad994c39d50c2d7457b74e6f55e3b083a6a1"}, "partition_paths": ["neg_site_confound_fbirn_s3_DISC", "neg_site_confound_fbirn_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_fbirn_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7f40a346bcefe0b597b5c0fef2fb543dca673a60ba4be31807aff17aa7312a5c", "task_id": "ncb21-task-7ae540af62da3c12"}
{"benchmark_case_id": "ncb-synthetic-stress-a08821ce404a9f53", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_abide2_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_abide2_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Limbic_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_abide2_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "a08821ce404a9f538e1a1c0a9c294576a43e94934bf7069fad1363312adfeb64", "dataset_id": "neg_p_fishing_abide2_s1", "discovery_cohort": "neg_p_fishing_abide2_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_abide2_s1_DISC": "940b4b8edb64d78383cbf69ae31331855698cf94f84b5d5a3c358315dd03b05a", "neg_p_fishing_abide2_s1_REP": "95564d1a48ef30bdc935a2020b860150f20bc3215b703839fc1b28986c2370a0"}, "partition_paths": ["neg_p_fishing_abide2_s1_DISC", "neg_p_fishing_abide2_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_abide2_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "cdb6a2ad5825c27c498cbe5ce8e953ad16adc87193dd5869609d340e95b7fa72", "task_id": "ncb21-task-7af88f86b61154a3"}
{"benchmark_case_id": "ncb-external-transfer-75d84aea42f71e47", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_mci_entorhinal", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "MCI", "control": "CN", "var": "dx"}, "outcome": "smri_entorhinal", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_entorhinal negative for MCI compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "75d84aea42f71e47f0246ca3b151b088e8ef3fce123bb1930a1f0227b349dbbf", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "e64fc8b4b7bf8b0a874f9c91cd623804eae7642306f52cb04fc0f0542acba5dc", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d5f1ef029d4ef266b50df566f4d4b922f0e3880db246000296e73c4b1e625f8b", "task_id": "ncb21-task-7b2cdd8e592c84a2"}
{"benchmark_case_id": "ncb-synthetic-stress-75f27bf902a69eb3", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_adhd200_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_adhd200_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_SalVentAttn_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_adhd200_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "75f27bf902a69eb3491dacf2f33de0bd4fe16d43b668d5a3245ffa665c7b45cf", "dataset_id": "neg_p_fishing_adhd200_s3", "discovery_cohort": "neg_p_fishing_adhd200_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_adhd200_s3_DISC": "8947f97b16467c192cbf916d044eb6b27b06a6d422f5321a3c8d5063ff9bb885", "neg_p_fishing_adhd200_s3_REP": "f80f5f35c82dafd05e8be40640c11eeb64795319fd1b6f557d5f63ed59257e4a"}, "partition_paths": ["neg_p_fishing_adhd200_s3_DISC", "neg_p_fishing_adhd200_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_adhd200_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fbd5c6ffc051c76a704ba6fdbd83eb5ddf36afae6453a7d24c36f8fe5070c996", "task_id": "ncb21-task-7bad2a2dd72cec13"}
{"benchmark_case_id": "ncb-synthetic-stress-56b080929487f10e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_abide2_s2", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_abide2_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_abide2_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "56b080929487f10e6fe160a40f382c06df6218a41f2c8ae69bfde6dba642d984", "dataset_id": "neg_underpowered_abide2_s2", "discovery_cohort": "neg_underpowered_abide2_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_abide2_s2_DISC": "10c70b6b668d3b346bab6aad17f0ba044f76db0f24ca4d13deddec3819d235d0", "neg_underpowered_abide2_s2_REP": "1c6e3bcdad0366b906e96907377d4006b45f6d1a83af62c08183097d3e72c944"}, "partition_paths": ["neg_underpowered_abide2_s2_DISC", "neg_underpowered_abide2_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_abide2_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c7e7987887d0f0c2dfd3b84bb1ab439a7e02422b0c74b6dc3b7010d8c494af31", "task_id": "ncb21-task-7bc03db196dcedff"}
{"benchmark_case_id": "ncb-scientific-1518a0abab435142", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q045", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Vis_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1518a0abab43514213f4d83221121b85df589c0db1f51783ab24f10b187a989c", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "2e8ca1fa68a1ceefd584df107b0c74c0f6322971d553a5483aafdc6e3a1c7d14", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1483b6cdb989ba92276e8b50ab799aa326ff93b4ef3a6ecaddf6faf02d2e4284", "task_id": "ncb21-task-7bc8d7047dac68a7"}
{"benchmark_case_id": "ncb-synthetic-stress-ddef0966bc3b9b24", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_abide2_s3", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_abide2_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_abide2_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ddef0966bc3b9b24d1a635d96253627648fe23781e08b8921a073005dcde3345", "dataset_id": "neg_site_confound_abide2_s3", "discovery_cohort": "neg_site_confound_abide2_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_abide2_s3_DISC": "05f0b1a4c54997da29180a4265299f10bf9bc52971729ad227587873a53a0a8e", "neg_site_confound_abide2_s3_REP": "1343964d2cd851f51b17b871b28addcd8b9bd75bfd63d120bdb3487615d0cd68"}, "partition_paths": ["neg_site_confound_abide2_s3_DISC", "neg_site_confound_abide2_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_abide2_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1ae6d9b8ee00408a53cb7a129e27368cc6529016d1da4fd2cf95547de9833a6f", "task_id": "ncb21-task-7bcd0163c4bd3c2c"}
{"benchmark_case_id": "ncb-scientific-8482b5c202e5e323", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_013", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_Default_Default_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, is higher age associated with altered default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for sex and cognition?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "8482b5c202e5e3235de8c6063dda4b78550e3f9e00df27d431e2d1f0d720b4aa", "dataset_id": "HCP", "discovery_cohort": "HCP_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["HCP_DISC", "HCP_REP"], "question_sha256": "1d30ca98b79841f53b77865c3dda5071edfd5285e121fc3805f2ee68ca7521b3", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c66e07626429ff9c193acb0de6f210b628f29af3dc8c55350b1c5649e95cd55b", "task_id": "ncb21-task-7e0c5c0ce3670607"}
{"benchmark_case_id": "ncb-scientific-4bafecc6ed3b9d87", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q017", "covariates": [], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_DISC, is SZ associated with lower fc_mean_positive than HC in an unadjusted group comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["ChineseSZ_REP", "BSNIP2_REP", "COBRE_REP", "FBIRN_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "4bafecc6ed3b9d87a26b408fcd1dd48f8e80cc184c6f98eb941ab54c48ad2031", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "ChineseSZ_DISC": "25886d87d5dc1da53df39d984bfa54f68aa99adbbbcb75b7d4826c4d8bdaff73", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_DISC", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "question_sha256": "d8607c5669ed576987535d932e063a92d7702cb0f9133fd9674dfe5589e32dcf", "replication_cohorts": ["ChineseSZ_REP", "BSNIP2_REP", "COBRE_REP", "FBIRN_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "268b69cf96dd2cc0db0b7bb8de6631724aaec624348baa790dda0f8d686b9662", "task_id": "ncb21-task-7eb216d2079d955a"}
{"benchmark_case_id": "ncb-synthetic-stress-88779694dc46460f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_adni_fmri_s2", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_adni_fmri_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_adni_fmri_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "88779694dc46460fb1e076cee83c5be4e30a97c854ecbfc8f239804f35ccebd7", "dataset_id": "neg_underpowered_adni_fmri_s2", "discovery_cohort": "neg_underpowered_adni_fmri_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_adni_fmri_s2_DISC": "b4aa30701d266907041b5f788cdb9d50e50b249e6b9a5144c5a08b4e7f7867bb", "neg_underpowered_adni_fmri_s2_REP": "e31e0190421fe007cd2a94ba9736b02a74cfdec825d3578a82b201f21aae0f3c"}, "partition_paths": ["neg_underpowered_adni_fmri_s2_DISC", "neg_underpowered_adni_fmri_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_adni_fmri_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b32cb62fe38209784a471701d33bde7642a3fb61f35147306ca15eeee0a53c49", "task_id": "ncb21-task-7faecca7162c861d"}
{"benchmark_case_id": "ncb-scientific-70527a90423a8295", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q042", "covariates": [], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ChineseSZ_DISC and ChineseSZ_REP, is the SZ-versus-HC contrast for fc_mean_abs directionally consistent in unadjusted comparisons using dx only and no covariates?", "replication_cohorts": ["ChineseSZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "70527a90423a8295ebeae835b0a95e8bc634a4d1611424dbdb775935515a8516", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ChineseSZ_DISC": "25886d87d5dc1da53df39d984bfa54f68aa99adbbbcb75b7d4826c4d8bdaff73", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8"}, "partition_paths": ["ChineseSZ_DISC", "ChineseSZ_REP"], "question_sha256": "3bd2c904f22d8f13ea47294aeb24776aa3d0c4a4a11fdbc9204b0fe207c1fd9a", "replication_cohorts": ["ChineseSZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1f25292a340946358354a285063b38888d03785da7aa7745ad6744533f28ed4e", "task_id": "ncb21-task-8139ac828c9a3687"}
{"benchmark_case_id": "ncb-external-transfer-3368778ccb30dbe8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_lateralventricle", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "positive", "group": {"case": "SCHZ", "control": "CONTROL", "var": "dx"}, "outcome": "smri_lateralventricle", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_lateralventricle positive for SCHZ compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3368778ccb30dbe804567ee9703c1619a73432aba9ce742095928a37022d8251", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "c259c860e7ad322176f7a9738bb2b05e696db11afb937c289d855763d7d5b754", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "e0a9b3a4f9f636c35626aed8dfd915750bc04054a0729396084d2f0bef2913e0", "task_id": "ncb21-task-81955622e1afddff"}
{"benchmark_case_id": "ncb-scientific-f849744a3e72c7b0", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_fc_abide2_internal_split", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "functional_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ASD case-control FC derivative-table split in fMRI-FC, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction two_sided and adjust for age;sex when available.", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "f849744a3e72c7b028ed76510b08cfa02e02e994548eb013b88324b322fee36a", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "8559379d23c5addc152235d042b44a9cb39d430784401f388980331bfa443435", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "01ccf3bb002b89ba29bfba523bc4ecbee316e7cb56b48ba423f06b9d88d1bfc2", "task_id": "ncb21-task-8268cb72ce15ece1"}
{"benchmark_case_id": "ncb-synthetic-stress-a17be850c0a76e0a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_oasis3_s1", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_p_fishing_oasis3_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_midtemp", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_oasis3_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 6, "selection": "discovery_only"}}, "contract_sha256": "a17be850c0a76e0a47d54b7c5ab9af8074c10539475800096965888ff45e2cf8", "dataset_id": "neg_p_fishing_oasis3_s1", "discovery_cohort": "neg_p_fishing_oasis3_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_oasis3_s1_DISC": "b1a1e457c5a20341c7f1817de696ab8ae22436d387ea534e0812b3e6daf361ff", "neg_p_fishing_oasis3_s1_REP": "3976fccd0f2e490d371492edd777c03cd78127ce2809d52d8c2cf7e2b2c3d146"}, "partition_paths": ["neg_p_fishing_oasis3_s1_DISC", "neg_p_fishing_oasis3_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_oasis3_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d34ceb8dfa10debea4b488949e17fb818d0cb5735bf61c7cc1da6c02fd6d3c5c", "task_id": "ncb21-task-82bc2831d6b1f058"}
{"benchmark_case_id": "ncb-synthetic-stress-dfbe62737d4d8555", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_oasis3_fmri_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_oasis3_fmri_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_oasis3_fmri_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "dfbe62737d4d8555178bbaa468c83f85ce4d4ddb051a2ba34c5428eb1dd7b8af", "dataset_id": "neg_p_fishing_oasis3_fmri_s1", "discovery_cohort": "neg_p_fishing_oasis3_fmri_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_oasis3_fmri_s1_DISC": "959714966a588e9d5a7c06a4f831aca7786a50b3f0bb7736cc0a58e78ece16aa", "neg_p_fishing_oasis3_fmri_s1_REP": "243212583294049293ebadeb08f2e9c28bbc982c67ee3e82c054890980df7879"}, "partition_paths": ["neg_p_fishing_oasis3_fmri_s1_DISC", "neg_p_fishing_oasis3_fmri_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_oasis3_fmri_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "cd58913b06a405b1b69c124367a17ac25ab4a4f3c828426f93575b2ed5c1a2fb", "task_id": "ncb21-task-835477c4104228f6"}
{"benchmark_case_id": "ncb-scientific-24de654ccd87dce2", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q042", "covariates": ["age", "sex", "site"], "discovery_cohort": "OASIS3_fMRI_DISC", "estimand": {"direction": "two_sided", "group": {"case": "2", "control": "0", "var": "dx"}, "outcome": "fc_fc_Default_SalVentAttn_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_fMRI_DISC, with OASIS3_fMRI_REP as a replication cohort, does fc_fc_Default_SalVentAttn_z differ between diagnosis code 2 and diagnosis code 0, adjusting for age and sex?", "replication_cohorts": ["OASIS3_fMRI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "24de654ccd87dce2402ee3e06841e2aa84bb5b939fe17e0a081e3e3fe8dd97e2", "dataset_id": "OASIS3_fMRI", "discovery_cohort": "OASIS3_fMRI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_fMRI_DISC": "7b701bee5bf1a2e4ded9c29c25ca16bc6ef6980169d9873326b362e29ecfa14d", "OASIS3_fMRI_REP": "b3ca261941658ec5a84c1f6f268e2261777e1bcd23bf28c7d2abe42d646aa786"}, "partition_paths": ["OASIS3_fMRI_DISC", "OASIS3_fMRI_REP"], "question_sha256": "ae0a6b3718b50be78aae2dfd1414ea0c8575b50352ce883304c031787c5bd369", "replication_cohorts": ["OASIS3_fMRI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "e7a9ac20d2245d82a20bdc2ce9c5fe26458b26b755f666408e3e8f574fbcbe91", "task_id": "ncb21-task-848513937ba8e347"}
{"benchmark_case_id": "ncb-scientific-970b61f9cba924c6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q026", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_fusiform", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with lower smri_fusiform than CN, adjusting for age and sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "970b61f9cba924c6d68292ce20e398b5486f23406238ab4f20992d5ff84ef2ca", "dataset_id": "OASIS3", "discovery_cohort": "OASIS3_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_DISC": "8a048aaff562775d7c80f7027c9d8bb56cc738b7563d25ca06af7cb33df89d31", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["OASIS3_DISC", "OASIS3_REP"], "question_sha256": "39825fec627a2e8426a5ffa557927023686d7b60551236745f601adda2bb29fe", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "3c495dae84f58d4abf858a19d61bceca9c1ea65f66b209e100a7fe9fae3188bc", "task_id": "ncb21-task-84cd5389a14a4ef5"}
{"benchmark_case_id": "ncb-synthetic-stress-aa9ca68bedbbb036", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_hcp_s1", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_hcp_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_hcp_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "aa9ca68bedbbb03631cfe8cb9096a624312e3528e7b18dd216a34e3688919238", "dataset_id": "neg_site_confound_hcp_s1", "discovery_cohort": "neg_site_confound_hcp_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_hcp_s1_DISC": "20dddb913e18ab7a693813e8fb0e05a7652fe8c1210926a3af922ae9bb3d42da", "neg_site_confound_hcp_s1_REP": "bb9956bb26d77957b8e70e8d95f24352f61eabd06ac0b27315ac354f97e184e8"}, "partition_paths": ["neg_site_confound_hcp_s1_DISC", "neg_site_confound_hcp_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_hcp_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f2d3ce8658c6e380af8302e4962fb440ccc3bcda9d377afbd9f36af8239288ac", "task_id": "ncb21-task-85262b3d4c12b804"}
{"benchmark_case_id": "ncb-scientific-0c04451321f8aa46", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q007", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_HOLDOUT", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_HOLDOUT, is fc_within_network lower in ASD than HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0c04451321f8aa463f1d1bfe0e785823e00d716a57d204c1b000827ea22d686c", "dataset_id": "ABIDE1_HOLDOUT", "discovery_cohort": "ABIDE1_HOLDOUT", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE1_HOLDOUT": "465b83b9275d056ca897367bc2b30907c1b32663d2fd4cdda4f87111fedb541c", "ABIDE1_REP": "d0a670f11f1c39a32e1e182cd1457b51acbec5518845795c26872642565c9f35"}, "partition_paths": ["ABIDE1_HOLDOUT", "ABIDE1_REP"], "question_sha256": "e908ac047680693321dcbc88a5558e4bce5ce73837d573f26ccd9441514e2c73", "replication_cohorts": ["ABIDE1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "8c47699fe8b988dbd5944a898ad307bddde2890fbf81b108ee63986e93226ba0", "task_id": "ncb21-task-853f5a3df22e30b3"}
{"benchmark_case_id": "ncb-scientific-09903e42ed156c26", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_38422833_pmid38422833_cortical_fnc", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": "cortical_functional_network_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded first-episode or early psychosis versus controls without a psychiatric disorder effect on cortical functional network connectivity in rs-fMRI functional connectivity, using BSNIP2 as discovery and COBRE as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "09903e42ed156c2690cdbe27471b1d9877a5a23f33b016ead3e1b12870fef1fc", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc"}, "partition_paths": ["BSNIP2_DISC", "COBRE_REP"], "question_sha256": "2b3aaeaee648421d90f5cebc8afa825e590bccaaffd0465c374864d091b40dbb", "replication_cohorts": ["COBRE_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "68a17b9ed9a90a3949cef1142b1b0ef87a4c60821325aa6a852d315411990c36", "task_id": "ncb21-task-8584aa7cd91b1892"}
{"benchmark_case_id": "ncb-synthetic-stress-f5dbfb11e9ef72d0", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_adni_fmri_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_adni_fmri_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_adni_fmri_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f5dbfb11e9ef72d0d8658a97046966cda507ac0780b28314e85083714400e8ab", "dataset_id": "neg_random_label_adni_fmri_s2", "discovery_cohort": "neg_random_label_adni_fmri_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_adni_fmri_s2_DISC": "37796b2a23f913d4a60787633c363f3e13e0a9fb4b053ce1ab3f516c2941df85", "neg_random_label_adni_fmri_s2_REP": "a306a9e4f2f69fd6c9d1007eb961064d96f91e3c93b21a67cc9f619e4cce95f1"}, "partition_paths": ["neg_random_label_adni_fmri_s2_DISC", "neg_random_label_adni_fmri_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_adni_fmri_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a8cad240b835f2a97e7a48a96dc1afb8c3f359203719283c110c95b202604583", "task_id": "ncb21-task-865bd36606531a72"}
{"benchmark_case_id": "ncb-scientific-05c17620b6ff0817", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_023", "covariates": ["sex", "site", "phen_fluid_composite"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_Default_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "site", "phen_fluid_composite"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, is higher age associated with lower default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for sex and cognition?", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "05c17620b6ff0817912306ae784d68f40f43538421d7a77238304c5941523117", "dataset_id": "HCP_Aging", "discovery_cohort": "HCP_Aging_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_Aging_DISC": "47082908a7b0b17d0b8a006028dff9d08a56af3f8c6e8d08627ca3818f85a4fd", "HCP_Aging_REP": "e4682154e236a020f91b7932fe75341cf7a0eed865089e5172cad83a6989e965"}, "partition_paths": ["HCP_Aging_DISC", "HCP_Aging_REP"], "question_sha256": "3a2841b6dab54d00ae1fee08edd897a970baa824bb5a81813de4975bf70d6ec0", "replication_cohorts": ["HCP_Aging_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "88def5bd9aa91e0d59be57f590e5cf33f43e1f7a9608cba3b08c1a73e2fda578", "task_id": "ncb21-task-873fe1c30cfa20cf"}
{"benchmark_case_id": "ncb-scientific-b274fb2db756fa8f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_wholebrain_atrophy_adni_oasis3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_wholebrain", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For AD whole-brain atrophy in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "b274fb2db756fa8fbe67b5bf4c76aa14a96203ae5a5dae6222358380236562c8", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "27b3b8973c48886671e13c09f7aba0b67e26d1c85bbef694fcd3d27c23592a03", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ff8bfd8203bb2bd391fa1648d6dbf623a40c3bf3da0729e591de7a2d8fbe2678", "task_id": "ncb21-task-875cfcac9041998a"}
{"benchmark_case_id": "ncb-scientific-0d57166941ee6987", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q044", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Vis_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered within-Visual connectivity (fc_fc_Vis_Vis_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0d57166941ee6987a8e94a201d566f6551e2f9cde82cc2d83fe95e4b02d7cf43", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "a7fab3000d3573d6d3f8433968329d071578091c5586b9190a0c00dba446da14", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fbcfc4528da4423574b7c3cc1988b7d6ab6a19eacca7d398d3af6413e83813ff", "task_id": "ncb21-task-8783c84319c13ec7"}
{"benchmark_case_id": "ncb-synthetic-stress-91ca48ca8f7976aa", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_abcd_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_abcd_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Default", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_abcd_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "91ca48ca8f7976aa306bb98f57b10c3e0b2a174135ce4a378861baaa1bc64979", "dataset_id": "neg_random_label_abcd_s3", "discovery_cohort": "neg_random_label_abcd_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_abcd_s3_DISC": "a1bf38f81c19484720e41c26d5ca1d7ba5dc49c917b1186e3c54af2bdb6d73a0", "neg_random_label_abcd_s3_REP": "8ce909cb8d8961bf5b39e69cffb542d3574b1e169fd6c388d6e85895f0c40aff"}, "partition_paths": ["neg_random_label_abcd_s3_DISC", "neg_random_label_abcd_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_abcd_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "827bede8730da5348dc3d786b1fb5a3c458fb9f2c7da54ce060af0365b3758f7", "task_id": "ncb21-task-87c689dc841ef716"}
{"benchmark_case_id": "ncb-scientific-138026bd7cce20e7", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_029", "covariates": ["age", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_Default_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, do females and males differ in default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for age and cognition?", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "138026bd7cce20e79ee446546ae110932c552bcf6e4739a76d5c5861dca44b69", "dataset_id": "HCP_Aging", "discovery_cohort": "HCP_Aging_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_Aging_DISC": "47082908a7b0b17d0b8a006028dff9d08a56af3f8c6e8d08627ca3818f85a4fd", "HCP_Aging_REP": "e4682154e236a020f91b7932fe75341cf7a0eed865089e5172cad83a6989e965"}, "partition_paths": ["HCP_Aging_DISC", "HCP_Aging_REP"], "question_sha256": "e5049a9b2e8be9fd15f4ecb8e1e7bd6ca6f4184d49b36ac1d7d02807dcbaf8ad", "replication_cohorts": ["HCP_Aging_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "cb4a3d3501c80b99d64551fb50814851f197a405a77a0e29cbeeac09f2191995", "task_id": "ncb21-task-899f07fc4e50962f"}
{"benchmark_case_id": "ncb-synthetic-stress-72743e2acf45d7e5", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_hcp_aging_s2", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_hcp_aging_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_hcp_aging_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "72743e2acf45d7e55949bf0ea09e32016ae5a4986d541d2c2defeb52252e3ec9", "dataset_id": "neg_site_confound_hcp_aging_s2", "discovery_cohort": "neg_site_confound_hcp_aging_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_hcp_aging_s2_DISC": "8d7587a759c352460f01b1326da1065bf52f66b8a4d25bd675fcc81e8d8ad75a", "neg_site_confound_hcp_aging_s2_REP": "1ac7b705c14197dac881ac6c08479d9026a1ae86425b223cf8565e0d6ef02dc0"}, "partition_paths": ["neg_site_confound_hcp_aging_s2_DISC", "neg_site_confound_hcp_aging_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_hcp_aging_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7c7e7bc3643914cca52e868aa90a673e92917bfabc28de44297eaeda75d12f34", "task_id": "ncb21-task-89d5b11b51787de2"}
{"benchmark_case_id": "ncb-scientific-adc64a42191e17f6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q013", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_DorsAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_DorsAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "adc64a42191e17f63007bc25281becbf3d5835b1b4907a7c66c7d4875362948d", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "778579800099c6d585924c98ec2c69a59dc9d6efc8ba7243193d1f06716cbf15", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f1876c5eb00f38c0b40e8f20d71439c9cf3fea6934ecb2815658418beecd51ce", "task_id": "ncb21-task-8c1c0d2918c17a43"}
{"benchmark_case_id": "ncb-external-transfer-717b76df43cc7ce7", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_bd_hippocampus", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "BIPOLAR", "control": "CONTROL", "var": "dx"}, "outcome": "smri_hippocampus", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_hippocampus negative for BIPOLAR compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "717b76df43cc7ce783428377f6663c8a8242b0602301306d5513c88ac53c39d3", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "b379d42006306c06e4177d96b6510ecdb62aca0d104732edf708e1778b13b0e3", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f3bbda24cbf2adf1bd35f0ce050f695386c6dc523db39079d165ea19f3c41418", "task_id": "ncb21-task-8c9b8c06fc709efb"}
{"benchmark_case_id": "ncb-scientific-2a5d5bc83ab86134", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_028", "covariates": ["age", "sex", "site"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, is higher cognition associated with lower default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for age and sex?", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2a5d5bc83ab8613499aab2ac0e974ec72a4dd0f1099d99320ee8a8e449b683b6", "dataset_id": "HCP_Aging", "discovery_cohort": "HCP_Aging_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_Aging_DISC": "47082908a7b0b17d0b8a006028dff9d08a56af3f8c6e8d08627ca3818f85a4fd", "HCP_Aging_REP": "e4682154e236a020f91b7932fe75341cf7a0eed865089e5172cad83a6989e965"}, "partition_paths": ["HCP_Aging_DISC", "HCP_Aging_REP"], "question_sha256": "639e36b3410fa5658b9c71b9e79b3702103c77666434efc4e28044c4800a890c", "replication_cohorts": ["HCP_Aging_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "38559bfcf568c4b651191314192f415b7205dbb1da22de2d0db1b72031bb3bc2", "task_id": "ncb21-task-8d9cde7a88a32741"}
{"benchmark_case_id": "ncb-scientific-e2c8b315d5871123", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_1431963_pmid1431963_mta_ad_vs_controls", "covariates": ["age", "eTIV", "sex"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_hippocampus", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "eTIV", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded probable Alzheimer's disease versus age-matched controls effect on medial temporal lobe atrophy in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction positive and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e2c8b315d58711232df3fb244f289b13f1a98c97f3043bbed5db37f77d0fac0a", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "2dc53034714df0fa1117c19b6bafccdebd2c66d63922f71e3c8a2cbbbc21493f", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7d1c83104741ed5b01b697d5a8021cc56dc98cc9628d8a91ecc6fa7ccc42c567", "task_id": "ncb21-task-8efc33f2fd8e4854"}
{"benchmark_case_id": "ncb-scientific-9306eed5ac12c7af", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_35583796_pmid35583796_rsfc_dmn_within", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Default", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded ADHD diagnosis versus controls effect on default mode network within-network functional connectivity in resting-state fMRI functional connectivity, using ABCD as discovery and ADHD200 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9306eed5ac12c7afb5d6c7513192e5e650af6d2ccd09172f90bd0be83b95b662", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ABCD_DISC", "ADHD200_REP"], "question_sha256": "fec24c80fd4b76d227cb257a90f867bca482a7e13d76fb0ad6c93c70edfef3ff", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f8413b5727abd7fe701db2fe03fa539e2cdc19504c6967e636818bf9b5177249", "task_id": "ncb21-task-8f1d97de95a41566"}
{"benchmark_case_id": "ncb-scientific-e61ccc72bef4061c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q038", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered DorsalAttention-Salience/VentralAttention connectivity (fc_fc_DorsAttn_SalVentAttn_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e61ccc72bef4061ce3d466c68b9f2898acb4cf373aa0cdf600d200efef581b25", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "72f823cd6727d3ca2473646d2fb99d420fad17685fc7a0dd7051f9255cb79731", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "bcbc62719dc9cf8604e9902e4891a802b961a32646ed29162c019a1eb6c975d4", "task_id": "ncb21-task-8f7b785586ca8640"}
{"benchmark_case_id": "ncb-synthetic-stress-35ab0b847aafb7de", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_fbirn_s1", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_fbirn_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_mean_positive", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_fbirn_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "35ab0b847aafb7de2e2678785d830cb00125095448dadd1b4ef99c2f50ad9935", "dataset_id": "neg_site_confound_fbirn_s1", "discovery_cohort": "neg_site_confound_fbirn_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_fbirn_s1_DISC": "25128daf537faade3e086fcd7056d5714fa8af14f434f1641c4d75c98d4d5608", "neg_site_confound_fbirn_s1_REP": "50f8a347aba1ae409176aad41052be15c520ccaf85da43fc3e0b2ec9c2b26edd"}, "partition_paths": ["neg_site_confound_fbirn_s1_DISC", "neg_site_confound_fbirn_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_fbirn_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ce42e524f1ca45ed8f2ce5547df7d9111aa46267c3efdb9f32f0343c9fb14596", "task_id": "ncb21-task-8f94223d440f690d"}
{"benchmark_case_id": "ncb-synthetic-stress-31e032722d8da786", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_abide1_s2", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_abide1_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_within_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_abide1_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "31e032722d8da7865e5b0ceb0d40da92b50875f23a49a2ce2de8822630994aca", "dataset_id": "neg_site_confound_abide1_s2", "discovery_cohort": "neg_site_confound_abide1_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_abide1_s2_DISC": "1cd5a2fe72eaba2da5aab0da9982645e6836118a8f6c84b6859fce3154451f89", "neg_site_confound_abide1_s2_REP": "e329e4fb4ca8fa40939049a2b91d2657f9668d76c121e57f8512ef806577dc73"}, "partition_paths": ["neg_site_confound_abide1_s2_DISC", "neg_site_confound_abide1_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_abide1_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "57c6d1ee5f149ff4f54a467184fcddfa39ad338897fa33281251cb3495b43865", "task_id": "ncb21-task-8fb7c5b3a5121fb1"}
{"benchmark_case_id": "ncb-synthetic-stress-b0ad25a9bd80f5a9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_oasis3_fmri_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_oasis3_fmri_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_SalVentAttn_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_oasis3_fmri_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "b0ad25a9bd80f5a9e2298aab7e437bba0f12606ef77cecb8bde1c530ad394121", "dataset_id": "neg_p_fishing_oasis3_fmri_s2", "discovery_cohort": "neg_p_fishing_oasis3_fmri_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_oasis3_fmri_s2_DISC": "2494277932cf3c53896a95b9b2cc9241e831d62401f12d67a95fe542e414a42b", "neg_p_fishing_oasis3_fmri_s2_REP": "1a68d7c8b90733bc1f6df93201f370178c88cac33d5f36648b92318b143ca6a5"}, "partition_paths": ["neg_p_fishing_oasis3_fmri_s2_DISC", "neg_p_fishing_oasis3_fmri_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_oasis3_fmri_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ebc481576a297b29fe752d7c91e45596b6f0b56c8fa0b3a7ed9a1e491650470c", "task_id": "ncb21-task-8fbf774b59af30ed"}
{"benchmark_case_id": "ncb-scientific-672ab5d3a6c11820", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q029", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Limbic_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered Control-Limbic connectivity (fc_fc_Cont_Limbic_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "672ab5d3a6c11820c5309d195f4983f50a16b545c77a52895353cabd01a16c41", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "8069bf44701accf46bd6077c1bf6e256531848908436c8c220dc354c8884d675", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "57bf1b3c8d9c648dc25efc38e4b6c1114c0ab6b08af9a702809fb5b4ed40105a", "task_id": "ncb21-task-9026d43b8d831fe5"}
{"benchmark_case_id": "ncb-scientific-1d82194a9c52b4fa", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q041", "covariates": [], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ChineseSZ_DISC and ChineseSZ_REP, is the SZ-versus-HC contrast for fc_mean_positive directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["ChineseSZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1d82194a9c52b4fa5071ac4e2534c4dcf3c59a3ec7bc0186d85580ca6cd85358", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ChineseSZ_DISC": "25886d87d5dc1da53df39d984bfa54f68aa99adbbbcb75b7d4826c4d8bdaff73", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8"}, "partition_paths": ["ChineseSZ_DISC", "ChineseSZ_REP"], "question_sha256": "867c969c3d97b711092991763d36949ea8dbefe84489dd86581ae4a78ea7f166", "replication_cohorts": ["ChineseSZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "88fca814e931735a6e7b19bbb6f8273b6e490ca40544d48dfd429283bcbb7dae", "task_id": "ncb21-task-9051660984b1ecd9"}
{"benchmark_case_id": "ncb-scientific-e5b2412738b16335", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q007", "covariates": [], "discovery_cohort": "BSNIP2_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_REP, is fc_within_network lower in SZ than HC in an unadjusted dx-only group comparison with no covariates?", "replication_cohorts": ["ChineseSZ_REP", "FBIRN_REP", "COBRE_REP", "Olin_SZ_REP", "JH_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e5b2412738b16335f55b1518f3aac394c8cfff48e1b39a9dc0d2b64c2cbb5877", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "JH_REP": "f40fac0acd9aa1425552a409658e883651432d578db1db8a9c290e2ea4850ae6", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "FBIRN_REP", "JH_REP", "Olin_SZ_REP"], "question_sha256": "6be75917f0e2f16e42737a15e1d03b83801e2cfd0f7880fd0c744de4b4194bea", "replication_cohorts": ["ChineseSZ_REP", "FBIRN_REP", "COBRE_REP", "Olin_SZ_REP", "JH_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "56c782efac5ece982421f6cc450e0a71823dbb420d4309f34cf0bab1b9426b92", "task_id": "ncb21-task-90944d2b4886bb16"}
{"benchmark_case_id": "ncb-scientific-67de4555230bc27a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q016", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "67de4555230bc27a2720a39d25ba2b54acdc13b8df64eb624e3b7162eb249cbf", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "654a3102c3e5567fe9888032fe503d19751fd9f4e96af2c0b8f3911ce7009c75", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "04cd4c226be0360077fe00bab7174c4acafdd43d7133e6dcd7acace0e45d5a44", "task_id": "ncb21-task-91d790dba534ab02"}
{"benchmark_case_id": "ncb-scientific-572d89238c32c460", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_smri_adni_oasis3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_hippocampus", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For AD hippocampal atrophy in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "572d89238c32c460c995e41986a179e9a5d92a3f833d3499a0a4c30ea9b4591d", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "a272797c98c16f6bad72d38eec4f74a57ed3e8a0d23d4f4f052e1e48be3f5b38", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d0b6b8c219d458c68ca3b6a197245ee4d8a65b4b971488d03ed6e84eff5bf700", "task_id": "ncb21-task-92fa7f071e5967dd"}
{"benchmark_case_id": "ncb-synthetic-stress-b0c5075602b380ed", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_cobre_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_cobre_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_mean_abs", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_cobre_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "b0c5075602b380edf2f56a66ff05b5325a5c7bd25a689e2625a431622f512655", "dataset_id": "neg_random_label_cobre_s1", "discovery_cohort": "neg_random_label_cobre_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_cobre_s1_DISC": "6c6db8db86abd3d77469f5b3d4e01df37155ae016d238ef62d4012e7c6b06661", "neg_random_label_cobre_s1_REP": "40e0fff6a9067e447534986f76e4a3fb3de8d9e348fef24591e9c6cb8662d635"}, "partition_paths": ["neg_random_label_cobre_s1_DISC", "neg_random_label_cobre_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_cobre_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "41ba8211d4c74015c5a5729a835d5b1276e9658170cad0f4953bdeca207622fb", "task_id": "ncb21-task-930d281b9beebc38"}
{"benchmark_case_id": "ncb-scientific-5a12e0c7d2a28bde", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_fc_abide1_site_split", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": "fMRI_FC", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ASD case-control FC ABIDE1 real site split in fMRI-FC, using ABIDE1_DISC_sites as discovery and ABIDE1_REP_sites as replication, test the claim with expected direction two_sided and adjust for age;sex when available.", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "preregistered"}}, "contract_sha256": "5a12e0c7d2a28bde4afc334c4453061c3551f223b203d5072532ad300d4b829d", "dataset_id": "ABIDE1", "discovery_cohort": "ABIDE1_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE1_DISC": "5a174cbcac2a070ea3f3af8be549a18c404215aaa031137242335f4c83643da4", "ABIDE1_REP": "d0a670f11f1c39a32e1e182cd1457b51acbec5518845795c26872642565c9f35"}, "partition_paths": ["ABIDE1_DISC", "ABIDE1_REP"], "question_sha256": "d30c16ffd54eccd21f10d874bf43276fc38cad0e135b77da258451563b2f8723", "replication_cohorts": ["ABIDE1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4fb7107690cc767e4792aeb50d39a413c39e6ab57ce22eccd0f85fb8c48ffbc5", "task_id": "ncb21-task-93d0f00b65344ed7"}
{"benchmark_case_id": "ncb-scientific-1d647c3ac871d92d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "szjh_symptom_cognition", "covariates": ["age", "sex", "site"], "discovery_cohort": "JH_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": "functional_connectivity_summary", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For schizophrenia symptom cognition anchor in psychosis, using SZ_JH as discovery and COBRE/FBIRN as replication, test the claim with expected direction two_sided and adjust for age;sex when available.", "replication_cohorts": ["COBRE_REP", "FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "preregistered"}}, "contract_sha256": "1d647c3ac871d92db5716b0119f805a94946d0e1cf26c683be44b13e0777834b", "dataset_id": "JH", "discovery_cohort": "JH_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "JH_DISC": "89ef38c838bb4c3dc85a3a7f214f6a8296e2aab6823ed97b158749b411f37bec"}, "partition_paths": ["COBRE_REP", "FBIRN_REP", "JH_DISC"], "question_sha256": "6d7d02b1972c0278dbd2f8b53e899938f076fa6dd4ba949f65a98971918b1218", "replication_cohorts": ["COBRE_REP", "FBIRN_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c3b3bcff663e32f08fdb07cee293fab79106386291cf4a5a2bd7a979999b68eb", "task_id": "ncb21-task-96088c72fd109620"}
{"benchmark_case_id": "ncb-scientific-4bec8588ceb4224d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_34280835_pmid34280835_adhd_smn-fc_01", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SomMot_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded ADHD diagnosis versus typically developing control status effect on interhemispheric somatomotor network functional connectivity in resting-state fMRI functional connectivity, using ABCD as discovery and ADHD200 as replication, test the claim with expected direction positive and adjust for age;sex;site when available.", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "4bec8588ceb4224ddd1ba5d8630aca64bbe57f5c572153bf88b8b92a099e90a4", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ABCD_DISC", "ADHD200_REP"], "question_sha256": "b64e3ace5cdd53ccd885f80b4e18d8a7d546e42a0835d42dcf0ec94079f6a606", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ce51729fb7a0bd13bdbe1d8ba0a11581a46eae9cb8fc9b213a752cbcc86f5f82", "task_id": "ncb21-task-966fa3f0d3b58999"}
{"benchmark_case_id": "ncb-scientific-149b1f2aeda4fcb1", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q037", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SomMot_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_SomMot_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "149b1f2aeda4fcb1612b5edd3c9ba5d3fdc4cc18d9c5aa1afa53e32c85ed567e", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "4bd4361ba4cf7dc3a6986e8a19a45870dac7fb4eb6849d8f90b89e5b6ad790d7", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7ab28dcdca4b51c56d5a1a1d9d87b587c0bf6ac49823ccce07f87d58ae19eba1", "task_id": "ncb21-task-96d84cbe7248ad9a"}
{"benchmark_case_id": "ncb-external-transfer-963d6d126e015ed1", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_amygdala", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "SCHZ", "control": "CONTROL", "var": "dx"}, "outcome": "smri_amygdala", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_amygdala negative for SCHZ compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "963d6d126e015ed1951ca4a09d65a38f7950d95a1ab654aaa720d117ad228067", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "98dfdae5060fcf8fee6118781f30ba26fcdad304cd93f33397925db47fa49a21", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "2bc6e59bc21a43dde7e3c29999ad46335272222f6c810f6ad0a78e054a23b049", "task_id": "ncb21-task-96fb9b5030208ca8"}
{"benchmark_case_id": "ncb-synthetic-stress-bc7a72687a803144", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_oasis3_s3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_random_label_oasis3_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_midtemp", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_oasis3_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bc7a72687a803144afcd25d9c0c1ef79cb070664947250e327acf067476ec7c1", "dataset_id": "neg_random_label_oasis3_s3", "discovery_cohort": "neg_random_label_oasis3_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_oasis3_s3_DISC": "cead2cecab4ab67c961709ae84795de94faf6931d7c85cf5b465282a4678b271", "neg_random_label_oasis3_s3_REP": "45991be2eaa9db95d33ef95e5b42d8fe051c4168fd141a120f9dd47576a4c5c1"}, "partition_paths": ["neg_random_label_oasis3_s3_DISC", "neg_random_label_oasis3_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_oasis3_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c3b113113456a22b0cf99b00a9978513f43963e94a37bb6038c8d4396d7acdf8", "task_id": "ncb21-task-979519f8c8ae0ade"}
{"benchmark_case_id": "ncb-scientific-b2bc1b3dc8d74234", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q003", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_DISC, with replication assessed in ABIDE1_REP, is fc_within_network lower in ASD than HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "b2bc1b3dc8d742349867f9f8a7e42fb3186657691ec0e71f041febf9a92913f6", "dataset_id": "ABIDE1", "discovery_cohort": "ABIDE1_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE1_DISC": "5a174cbcac2a070ea3f3af8be549a18c404215aaa031137242335f4c83643da4", "ABIDE1_REP": "d0a670f11f1c39a32e1e182cd1457b51acbec5518845795c26872642565c9f35"}, "partition_paths": ["ABIDE1_DISC", "ABIDE1_REP"], "question_sha256": "dca138f48aa414436004e49ce89d984b557b2c9ddba97052b8a4ec9f2e1f8b8f", "replication_cohorts": ["ABIDE1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "52d55c3f9660db4205ad27aba335895f8377bbd49b6fd0702300d037ab85e620", "task_id": "ncb21-task-9844744e93e5574c"}
{"benchmark_case_id": "ncb-external-transfer-9c7a47dbebfe1759", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_accumbens", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "SCHZ", "control": "CONTROL", "var": "dx"}, "outcome": "smri_accumbens", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_accumbens negative for SCHZ compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9c7a47dbebfe1759a0b310c27fec449c761d034846196c9372d436a7fa570a34", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "d20f98d5266325de494f1804636bb9f8f0b44c8f3c95f5c72a0c6e0217a6de96", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "85e76ff2f0d3346b4d63e55ade5b6046f511aa93b720049a506989829ed9bb89", "task_id": "ncb21-task-991c1aea260f8443"}
{"benchmark_case_id": "ncb-external-transfer-34b0d6368d06370a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_fusiform", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_fusiform", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_fusiform negative for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "34b0d6368d06370a0ad2f1f57784c27ece0112459c0a437df60c2544aa031708", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "e1ac5f2ea2798663142a611fb254c5c874ba738a6c2ece02c455b8ef05707275", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "41a1beb99613e6e3d960f099936162b2884bc10b2de2677ed94496bb29b1441e", "task_id": "ncb21-task-996e632551685164"}
{"benchmark_case_id": "ncb-scientific-b5c857772b8292df", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_26306871_pmid26306871_widespread_dementiaad_smri", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_", "predictor": "confirm_dx", "region_set": "smri_morphometry", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 6, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded dementia-stage Alzheimer's disease versus earlier-stage AD or non-AD comparison effect on hippocampal subfield morphology / widespread hippocampal atrophy in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "b5c857772b8292dff93bcb95c7fb4c0be82f61504c26048b086fe5058608e8d9", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "90428df4575c3939485af537eb6e2acb18986adeb5e47bd44912091fa7fd1bf5", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "3721ff6d1e234b4afdbc165fb6b70abb10b570b3715617de4b60a05e9fd1da25", "task_id": "ncb21-task-9b0ef08d451df5cf"}
{"benchmark_case_id": "ncb-synthetic-stress-e781a1d10147abaa", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_ukb_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_ukb_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_SalVentAttn", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_ukb_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "e781a1d10147abaa0fbadedc9ccbec3131903d0f7eac7d859974845d1eb42d2e", "dataset_id": "neg_p_fishing_ukb_s3", "discovery_cohort": "neg_p_fishing_ukb_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_ukb_s3_DISC": "10a9c9faf1fb6b2b3985237438d5a3f0c272a717edd1a5b3e83aa9adcdd72ff9", "neg_p_fishing_ukb_s3_REP": "b4020aa0cc3915f437420a9937ed33f6060001d8a1edc95b5fcfc54aa9342966"}, "partition_paths": ["neg_p_fishing_ukb_s3_DISC", "neg_p_fishing_ukb_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_ukb_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "2e0c225308ba39e4d10de7a05130b0ae10d9431bc84a1171f0258736fd2a1aa8", "task_id": "ncb21-task-9b4065e12594078d"}
{"benchmark_case_id": "ncb-scientific-456c48345929eb71", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_020", "covariates": ["age", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_SomMot_SomMot_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, do females and males differ in somatomotor within-network connectivity (fc_fc_SomMot_SomMot_z), adjusting for age and cognition?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "456c48345929eb71ad0b3a52855e1c8ae6d77f6e6ac96e12dc58ebe0ecd43705", "dataset_id": "HCP", "discovery_cohort": "HCP_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["HCP_DISC", "HCP_REP"], "question_sha256": "18d607e826ddb60b2ac1b306496243e0e6b99d75c58f65c3f2eee46d3189eec2", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "9fbd80f0dfe16264f74d4785f4f0d8515c9b75c703c0bef523e380b28442c67f", "task_id": "ncb21-task-9b8b8215a1ce887d"}
{"benchmark_case_id": "ncb-scientific-6f07b924f78e762d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_001", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_Default_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower within-network default-mode connectivity (fc_fc_Default_Default_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6f07b924f78e762dbb04192421df62ac5dd24835b8e50993a3f5c2cdf333e66c", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3", "UKB_REP": "6da6a67cb610290a28f97b077dd2aa0e82c39161e4b3c622857cb54843df2357"}, "partition_paths": ["UKB_DISC", "UKB_REP"], "question_sha256": "4d7298eb66c722a70b4bac20a8e6de4ad6974e0039e7e12c984a6983f924c52c", "replication_cohorts": ["UKB_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "984c1b7aa9006c12806a12042a62e1cd3b282f6b95bd928ee3c6451cba48a885", "task_id": "ncb21-task-9b937c1f9c6db20c"}
{"benchmark_case_id": "ncb-scientific-e313edffc6da7a07", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q036", "covariates": [], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across BSNIP2_DISC and BSNIP2_REP, is the SZ-versus-HC contrast for fc_between_network directionally consistent in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e313edffc6da7a074c42d69ed32da20e4642325dccd086815d410b2e3f7babb3", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23"}, "partition_paths": ["BSNIP2_DISC", "BSNIP2_REP"], "question_sha256": "f5de6e46a00901bc2f4d78a53550d7bcb314b4517ed4e66369efcf423d4e1580", "replication_cohorts": ["BSNIP2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f555ea3e77e68e7c98be57a506ff641953f2f8e879082a91e5d6b59613b497bb", "task_id": "ncb21-task-9bf0eb30f9254c4a"}
{"benchmark_case_id": "ncb-scientific-9b768a7494df75b2", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q035", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_SalVentAttn_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9b768a7494df75b24fdc89ed6f68cee71fad50a0a2b02684368bd092524d7453", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "cc88496de58670781aed65abe013d8c721c72856c10474b29626ea483fab47ad", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "34faf88bd89d0c4f362e96b2369f27a67bd925de778c0223dbbc6647d0c61b85", "task_id": "ncb21-task-9c7e5e6bd554af68"}
{"benchmark_case_id": "ncb-synthetic-stress-015db0b6e9d5687e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_hcp_s3", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_hcp_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_hcp_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "015db0b6e9d5687ec19738349420306cc81f28b8433ef780d0d7db2024f1ce1f", "dataset_id": "neg_underpowered_hcp_s3", "discovery_cohort": "neg_underpowered_hcp_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_hcp_s3_DISC": "e04f2afef4a828855c249f85aa7eba7fde92e57bdd595d0952a2554c49ca0edc", "neg_underpowered_hcp_s3_REP": "2f0d853d4bda0722c0dfe7535aee2bfb695c4dd44ee46e1d3587e951a1bdc81b"}, "partition_paths": ["neg_underpowered_hcp_s3_DISC", "neg_underpowered_hcp_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_hcp_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "54b36d53665eca136b68db1b5d14d2f9fa6426ff7b3bc7492aa1047013d3f291", "task_id": "ncb21-task-9ce60cabf58259fd"}
{"benchmark_case_id": "ncb-scientific-5e9d9106292eb159", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q008", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_REP, do SZ and HC groups differ in fc_between_network in an unadjusted dx-only comparison with no covariates?", "replication_cohorts": ["Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5e9d9106292eb159971d41de9ac66f7064ff9c67b369099bff308886a86ec58b", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "Olin_SZ_REP"], "question_sha256": "539b160493847b933e8d92aaf045515cc705c8b11a9796de97cf167c53cba37d", "replication_cohorts": ["Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "298e9158fa037cf9e1e95471f0ab0f7d06eb5bc02db17c8a87a48d226a8bacd1", "task_id": "ncb21-task-9de8790b14dd8e89"}
{"benchmark_case_id": "ncb-scientific-d37402dd791a12dc", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q030", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 1.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered DorsalAttention-Salience/VentralAttention connectivity (fc_fc_DorsAttn_SalVentAttn_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d37402dd791a12dc5975c0b5a9fc0994be3d63826bdbf317c431e337efa54f61", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "292a25ddcfeea37f416e546f540c64b17449babb3a50f8339797531ea860787d", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d003381a01bb233a9475b078649877a01efae6bfdb87a9fd8387c75a2a4c0fc4", "task_id": "ncb21-task-9e1aef9a7ecc24a2"}
{"benchmark_case_id": "ncb-scientific-de1363fa0a54a318", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_35338900_pmid35338900_boysadhd_limbicdmn", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Limbic", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "sex == \"M\"", "question": "For literature-grounded boys with ADHD / ADHD-by-sex group contrast effect on frontal-limbic striatum connectivity with default mode network regions in fMRI-FC, using ABCD as discovery and ADHD200 as replication, test the claim with expected direction positive and adjust for age;sex;site when available.", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "de1363fa0a54a31857453e1dd873734715696b750931e1ee29d64fb8103b2e58", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ABCD_DISC", "ADHD200_REP"], "question_sha256": "a866e8fbfb0b9b2be4c550835cb012680627589fd242f70ba3ad9864d827bd3f", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f8bdf3c57e6489f08c59b2722098f4fb25d03ddbfe03f62e417ac563efd6067c", "task_id": "ncb21-task-9e56ed379ff23dcc"}
{"benchmark_case_id": "ncb-scientific-23a83dcb8dd0287e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q030", "covariates": [], "discovery_cohort": "FBIRN_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In FBIRN_REP, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted dx-only comparison with no covariates?", "replication_cohorts": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "23a83dcb8dd0287e82e81be378cb004bce79a5325cd73ba2c55edfee8113d52d", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "question_sha256": "171a3cc3dbdf8c1b7c23a009735fbf4287cfb98beaf7f8702212c8a20b5ee413", "replication_cohorts": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b2745ce53c4e23c0e4ff789825737a4d51031543509f97fba574aec6415bc8b9", "task_id": "ncb21-task-9e6e0c742f90a6aa"}
{"benchmark_case_id": "ncb-external-transfer-a8646216db807141", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_paracentral", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_paracentral", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_paracentral negative for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a8646216db807141e5fa3c071adb36cd3d38b0fb6f84bd96d6b97235462c4ac9", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "b81ec785bd815a834d8aa82d51f348c634933b400748f10de01989883c477ec3", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7903a82e8815e6ea98e238d2a6a40fa537a55c200ce3cdffdb1a15a33beaa587", "task_id": "ncb21-task-9f2d3e04810b8017"}
{"benchmark_case_id": "ncb-scientific-107375390c1725d9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_fc_abide2_site_split", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "functional_connectivity_network_pairs", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ASD case-control FC site-split in fMRI-FC, using ABIDE2 site A as discovery and ABIDE2 site B as replication, test the claim with expected direction two_sided and adjust for age;sex;site required when available.", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "107375390c1725d9e23783f39ce428d1fd3b9ce4be9cf0e594d4be754f8ca7be", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "aec1a2645518fc3ad218f5fdef34b38048a9542a8b085781d7e91feeb982c8f6", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "e11624331073754d217cd6d02514d53a4586a35a04fb87180551a183ae1a1e89", "task_id": "ncb21-task-9f9f288578b02153"}
{"benchmark_case_id": "ncb-synthetic-stress-611a2fe389785bcf", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_cobre_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_cobre_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_between_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_cobre_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "discovery_only"}}, "contract_sha256": "611a2fe389785bcfa8f2f79858f987bfe37aa385532a19416af6f733572b5f6e", "dataset_id": "neg_p_fishing_cobre_s3", "discovery_cohort": "neg_p_fishing_cobre_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_cobre_s3_DISC": "5d38fb8b076e81e9583cfeeab2b204c91ae57c028ebd3c37845394ce477fb167", "neg_p_fishing_cobre_s3_REP": "133a235bd5e5b93c2ddc56249ab73bd7733b85d7b95e740c68f1783c39aa7fe9"}, "partition_paths": ["neg_p_fishing_cobre_s3_DISC", "neg_p_fishing_cobre_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_cobre_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "cdfd9fb990edd78a753315d56315b32966b8afcaee334cec8c9a58288c133fed", "task_id": "ncb21-task-a044560ca4a0ae22"}
{"benchmark_case_id": "ncb-scientific-ee627d7a5d823df0", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_025", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Vis_Vis_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, is higher age associated with lower visual-network within-network connectivity (fc_fc_Vis_Vis_z), adjusting for sex and cognition?", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ee627d7a5d823df05e627bdf39c5c62a61d74c6453f8c490dc39a233a4ecf6a1", "dataset_id": "HCP_Aging", "discovery_cohort": "HCP_Aging_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_Aging_DISC": "47082908a7b0b17d0b8a006028dff9d08a56af3f8c6e8d08627ca3818f85a4fd", "HCP_Aging_REP": "e4682154e236a020f91b7932fe75341cf7a0eed865089e5172cad83a6989e965"}, "partition_paths": ["HCP_Aging_DISC", "HCP_Aging_REP"], "question_sha256": "e8a90461e74ec7ea6bd2848fdbda5621c505143c5489c8da0aa3baa02a292dfd", "replication_cohorts": ["HCP_Aging_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "8249688c6f2a3bf2ee6318ee1ece4a74e701ea1dee3f6653a9ca51127321ac8f", "task_id": "ncb21-task-a054e2f3a1e18f45"}
{"benchmark_case_id": "ncb-scientific-872c426870a43fc0", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q003", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_DISC, is SZ associated with lower fc_within_network than HC in an unadjusted comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "872c426870a43fc09bee7deefd9487ffedf554184b618cfa1548e9f8d3be8d34", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_DISC", "BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "question_sha256": "af1e3ea30c2d14dca25b864e581917b849d1fce778a0ae1bb2311ff513f67c9e", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fe62e3ac6d28beb064c5546f2587c5a19f801cdd2d676bd8f8bb68fb9a52a192", "task_id": "ncb21-task-a05795cc3d5cda20"}
{"benchmark_case_id": "ncb-scientific-5e6aa7181e35b605", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q021", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SalVentAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5e6aa7181e35b6057dcfa0b2ef30e1accaf27ffa30c7110a71e05a7d42cd2bf4", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "9dbb04d49595ab31799f0dff4ca9d3191283f2fe277327880665d6e8e5da2ea7", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "2c09d04c1120857aecd0dcb6e15970743a11a4da5e328c593d3c4e7928ffd244", "task_id": "ncb21-task-a18bfcd804ec2d1e"}
{"benchmark_case_id": "ncb-synthetic-stress-65ed609046c27500", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_cobre_s2", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_cobre_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_within_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_cobre_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "65ed609046c2750096bdeed2696ee264aecdf77935ccb41b7b3aa45e6bed6379", "dataset_id": "neg_site_confound_cobre_s2", "discovery_cohort": "neg_site_confound_cobre_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_cobre_s2_DISC": "bcd4384912a1ef042bfff75fb75cfb95f66f201d837fcb28c601627031f4e956", "neg_site_confound_cobre_s2_REP": "8d43c4a3926488accb7a1012207c6d83bb410219e03c6308f0bb65f0a1e59e96"}, "partition_paths": ["neg_site_confound_cobre_s2_DISC", "neg_site_confound_cobre_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_cobre_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "229047990b5fc5493db560f78e2ad19bf51e4fad9ed3acf7d7005b738301056d", "task_id": "ncb21-task-a1a2fcf5dd82c92b"}
{"benchmark_case_id": "ncb-scientific-7c66a10417fcec23", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_35388950_pmid35388950_ad_hav_volumes", "covariates": ["age", "eTIV", "sex"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_", "predictor": "confirm_dx", "region_set": "AD_related_smri_volumes", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "eTIV", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 6, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded Alzheimer disease versus normal aging control status effect on AD-related structural atrophy pattern in sMRI volumetric MRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction two_sided and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7c66a10417fcec235ed58bc5f85855df3d432c60693fa1bf4758147bfb882606", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "1077a6329450b1493818e951eefaf9a1918c00ec0d8763461e263fa9833b1f23", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "8eba6d86a6275d37758772abe9d281aac14b3ecc57cff96ed9267a4a2247a561", "task_id": "ncb21-task-a1a56104fcdaf492"}
{"benchmark_case_id": "ncb-external-transfer-569510b14fd88380", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_midtemporal_random_label_s20260725", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_midtemporal", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_ad_midtemporal.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cb99d85c37156d750cd33985f727208fc6076a59810b54ccaa0af4a96d96981d", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "82bf370cd2fe7984723a82adc981737db2ead5520c217b38ffbdcff392f97070", "selected_assignment_rows_sha256": "0e0dee792670ceb4693cc5ab79ba69b3f20433e3ddb2b6506deb507f530d1d3c"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "0e0dee792670ceb4693cc5ab79ba69b3f20433e3ddb2b6506deb507f530d1d3c", "discovery_seed": 20260725, "group_column": "ncb_random_group", "parent_external_claim_id": "ad_midtemporal", "replication_seed": 21260725, "seed": 20260725, "selected_assignment_rows_sha256": "0e0dee792670ceb4693cc5ab79ba69b3f20433e3ddb2b6506deb507f530d1d3c", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "192b85735de738f271e56b695f37cf547495898511dd37450a7a6495578dfd6a", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6bb3966ec69212f8f82fa90101431d0d7ce0f4375d15496a8397a7a09d7d6458", "task_id": "ncb21-task-a236c325dde04b84"}
{"benchmark_case_id": "ncb-scientific-2290e2c4612f7606", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q033", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_wholebrain", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In ADNI_DISC, among CN participants, is older age associated with lower smri_wholebrain, adjusting for sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2290e2c4612f7606a50c7a7de849ae8a00aa0d67c1cb0d41adda7d27c1cec0f3", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "25c46966a02fefcc882cd492f918798f98d9d71b135b2cc888744d40d8bc6252", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "715a652ee2118f7897596a57d5b11b6dcee84908159854c5ef9c6d9dae750dbe", "task_id": "ncb21-task-a28ed8ee092fce61"}
{"benchmark_case_id": "ncb-scientific-2aadc4e4de851c0e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q005", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_HOLDOUT", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_HOLDOUT, is fc_mean_abs lower in ASD than HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2aadc4e4de851c0e2f50ccae550c5f5b5318d46843b677d9fa6b9b8ee0ab5262", "dataset_id": "ABIDE1_HOLDOUT", "discovery_cohort": "ABIDE1_HOLDOUT", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE1_HOLDOUT": "465b83b9275d056ca897367bc2b30907c1b32663d2fd4cdda4f87111fedb541c", "ABIDE1_REP": "d0a670f11f1c39a32e1e182cd1457b51acbec5518845795c26872642565c9f35"}, "partition_paths": ["ABIDE1_HOLDOUT", "ABIDE1_REP"], "question_sha256": "f8e28f46161621085facc3c7bf340714e8f5bfc7229f2a8983b04278530a681d", "replication_cohorts": ["ABIDE1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "bea818338f288e1e2e3be69ccef4d0d237cff3db3e178da086c96eef7ebb6394", "task_id": "ncb21-task-a2c95f837064e61f"}
{"benchmark_case_id": "ncb-scientific-d6cbeb536d2b0163", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_036", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Cont_Cont_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher cognition associated with higher control-network within-network connectivity (fc_fc_Cont_Cont_z), adjusting for age and sex?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d6cbeb536d2b01632b3c753bd865bcb7f96749ca7f83705faf307f82a8ceda07", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "91db835974b0b3a4116f0ca5bfba75df642f5cb9e2df009aa224269244928cdc", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "9e63074cf36234974e50a155d2a5a353103ad45fcf26453f76da5fd49fd71f89", "task_id": "ncb21-task-a2cefcd7709126f7"}
{"benchmark_case_id": "ncb-scientific-c64dac21d8591104", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q031", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, do ADHD cases (dx=1.0) differ from controls (dx=0.0) in Limbic-Visual connectivity (fc_fc_Limbic_Vis_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c64dac21d8591104aa2912c0fc623cb3df7ae2fad45f89683dcc7f18692dc403", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "4037e2e75b04cd9206d8c402d57a297ff5c80638d0578700e00a403422e06da0", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c324ba257320a23e560e6c562bf89909368d9cd09f43cd48515fe66601be4753", "task_id": "ncb21-task-a32df69d3ffcf15e"}
{"benchmark_case_id": "ncb-scientific-cc1c11b70cdbc35f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q036", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "pet_av45", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In ADNI_DISC, among CN participants, is older age associated with higher pet_av45, adjusting for sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cc1c11b70cdbc35f0fb7b7692822abca760f09315d96cba5c2e0c0d8c07fcfe3", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6"}, "partition_paths": ["ADNI_DISC", "ADNI_REP"], "question_sha256": "17ef9671c214ecfe60e3d1d6f4a056a94c24992d89c2b4b35ee417f8bfc4cfc2", "replication_cohorts": ["ADNI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "33630bae3c1c57446d8568d4a1d6be8caffddf55aa18b716e424c71fe7c68e23", "task_id": "ncb21-task-a389468db376c4f4"}
{"benchmark_case_id": "ncb-scientific-ff4d46696cfed68a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q010", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ABIDE1_DISC, ABIDE1_REP, and ABIDE1_HOLDOUT, is fc_mean_abs consistently lower in ASD than HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_REP", "ABIDE1_HOLDOUT"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ff4d46696cfed68a15180d4899c7d603dd7670c50318e776fa4991d2d5e8a6fe", "dataset_id": "ABIDE1", "discovery_cohort": "ABIDE1_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE1_DISC": "5a174cbcac2a070ea3f3af8be549a18c404215aaa031137242335f4c83643da4", "ABIDE1_HOLDOUT": "465b83b9275d056ca897367bc2b30907c1b32663d2fd4cdda4f87111fedb541c", "ABIDE1_REP": "d0a670f11f1c39a32e1e182cd1457b51acbec5518845795c26872642565c9f35"}, "partition_paths": ["ABIDE1_DISC", "ABIDE1_HOLDOUT", "ABIDE1_REP"], "question_sha256": "5bb6a111662d9a6480cf56bdb0538109851d07757d8050b3b0e86642b146273a", "replication_cohorts": ["ABIDE1_REP", "ABIDE1_HOLDOUT"], "schema_version": "2.1.0", "scientific_core_sha256": "0c31d1878724b277aab674a0169eaa62f9cd8b8f87554e1aff5b230be216412d", "task_id": "ncb21-task-a5379172f56f4390"}
{"benchmark_case_id": "ncb-scientific-46c685780a6efe6d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q024", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_DorsAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_DorsAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "46c685780a6efe6d8000426a098ef58223dceb61be99792eabb6a33e80beadb1", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "f380a8774ede070e916ad9e129d1def8dde79bce998c83260af51133bfb96872", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "df94ea643f6a82d627ef77486a98d9c3890f524be2f69524be3b4a40f2284f3d", "task_id": "ncb21-task-a56f004a7108ee69"}
{"benchmark_case_id": "ncb-scientific-feb70aa94fa7c90f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q047", "covariates": [], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ABCD_DISC and ADHD200_DISC, using each cohort's available ADHD-control coding separately (ABCD dx=1.0 vs 0.0 excluding missing dx; ADHD200 dx in {1,2,3} vs 0), is the ADHD association with Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z) in the same direction, with no additional covariates?", "replication_cohorts": ["ADHD200_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "feb70aa94fa7c90fa2df8c05f733ba5d944a5de106a49eb36eb63cbfa0415e66", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd"}, "partition_paths": ["ABCD_DISC", "ADHD200_DISC"], "question_sha256": "8b63ca6230fea2f14399ec682f45c8c5b098b159b529849780b7bac031ce5ac8", "replication_cohorts": ["ADHD200_DISC"], "schema_version": "2.1.0", "scientific_core_sha256": "f5ac6bbdb3a6e7f198712152259b8996498b8a69dd1a301e6fae213e1d03f000", "task_id": "ncb21-task-a71d3a3c1b344c50"}
{"benchmark_case_id": "ncb-synthetic-stress-5d0e6a346e90515f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_abcd_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_abcd_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_abcd_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "5d0e6a346e90515f7a62d3b2b01ca44320fe580fb1997f3b00c6c1e91fa2e7dc", "dataset_id": "neg_p_fishing_abcd_s1", "discovery_cohort": "neg_p_fishing_abcd_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_abcd_s1_DISC": "cec29b793ddd963e0f406ec89be07796069a4aa1e509f7e757e2dc9926808553", "neg_p_fishing_abcd_s1_REP": "7f0c0e1c2a32a5a7cfe6f2a73965359440ad16546d1ab805096addfa41cb3811"}, "partition_paths": ["neg_p_fishing_abcd_s1_DISC", "neg_p_fishing_abcd_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_abcd_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "021f5de80690e9d8387af42c173d4ae61bb7a25433c2c5f5e1c4cb189bcaed2b", "task_id": "ncb21-task-a808920481e064bd"}
{"benchmark_case_id": "ncb-scientific-2b8c1957240b2b85", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q024", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_wholebrain", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with lower smri_wholebrain than CN, adjusting for age and sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2b8c1957240b2b852adfb606d88c4a9eec86d9078c3aac22a990d5bdbcd1b36c", "dataset_id": "OASIS3", "discovery_cohort": "OASIS3_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_DISC": "8a048aaff562775d7c80f7027c9d8bb56cc738b7563d25ca06af7cb33df89d31", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["OASIS3_DISC", "OASIS3_REP"], "question_sha256": "da3fc0b5a32c241d884eb531ccabf0d99b59db475b22234bbb2901c8d57ee28c", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4c359022a7d66ce9cf434b746f612f69f3d30de32a31ee2a01092a69063df95c", "task_id": "ncb21-task-a9121137ac022382"}
{"benchmark_case_id": "ncb-synthetic-stress-be65950958048714", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_adni_s3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_p_fishing_adni_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "pet_av45", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_adni_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 8, "selection": "discovery_only"}}, "contract_sha256": "be65950958048714b102f2f415f25b4eb4e107ea0c1fa5b1e3207c98bdf2ba79", "dataset_id": "neg_p_fishing_adni_s3", "discovery_cohort": "neg_p_fishing_adni_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_adni_s3_DISC": "22c76013fd6eb6763e6b24be832199c8a9b0bccc3c395d29644808905370ce39", "neg_p_fishing_adni_s3_REP": "e2f29d905e4c9e35fb6f26ab6cdae25078848aa16d44792f8989d9f5bd8c500e"}, "partition_paths": ["neg_p_fishing_adni_s3_DISC", "neg_p_fishing_adni_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_adni_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "dbc398d6fa08eec2555741161d11581b8d84405d107b222a5fb71c758e135730", "task_id": "ncb21-task-a939ff446f75ebc3"}
{"benchmark_case_id": "ncb-synthetic-stress-0cd02a3132b5afda", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_abide2_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_abide2_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_SomMot_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_abide2_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "0cd02a3132b5afda35a56670b90451b2fba87c7caa9c600b4a5873768af9b48f", "dataset_id": "neg_p_fishing_abide2_s3", "discovery_cohort": "neg_p_fishing_abide2_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_abide2_s3_DISC": "58686e494d12064d4db773ffbf934d5248038966d90c398f0f029f9d161534cf", "neg_p_fishing_abide2_s3_REP": "89795e77f0706757212b7272ba7a386e2a9f432be6b399ea79cb44d7b40eaa56"}, "partition_paths": ["neg_p_fishing_abide2_s3_DISC", "neg_p_fishing_abide2_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_abide2_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "81d00a9c052f71889120169339ec7d6812b21fd04b190264e28c7e0f3dc172ff", "task_id": "ncb21-task-a94c28a45671c546"}
{"benchmark_case_id": "ncb-scientific-32c06a5e43e74faa", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q013", "covariates": ["age", "sex", "site"], "discovery_cohort": "COBRE_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_REP, is SZ associated with lower fc_mean_positive than HC in an unadjusted comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "32c06a5e43e74faa24d16e67accf4262d0369671f06216c693238d120d8f16f9", "dataset_id": "COBRE", "discovery_cohort": "COBRE_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "question_sha256": "32af0075f3b30c16797035845ea20ac9d213eae7c533b28921ea09373eab2c07", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "cd5852946b1fb0165fd071056090b542c14f152976505671ed1a1350b0d90fd2", "task_id": "ncb21-task-a94f030e722dccd8"}
{"benchmark_case_id": "ncb-scientific-206dd8d45a4d9d89", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q050", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_SomMot_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "206dd8d45a4d9d891eb2644f5acdf1aeb9a4d894209c6c0c3142e2a74481d2e3", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "9a8b3ada48613ae7ef76b281498919c153b6d6f8b7b95da20a56fc642bf02251", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6154ed998fd488938d7d3abf13ad63488d92cef6d199bf24bb49ae449b341e3e", "task_id": "ncb21-task-a9bd3530545a0c3f"}
{"benchmark_case_id": "ncb-synthetic-stress-ca59e7bcf2e17f7b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_ukb_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_ukb_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_ukb_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ca59e7bcf2e17f7b442348c7469169bd2ab4765abe4bccaf5184c3c5b6a90b78", "dataset_id": "neg_random_label_ukb_s1", "discovery_cohort": "neg_random_label_ukb_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_ukb_s1_DISC": "8054d47894d5a1d059e1691247773d32871b73f14f977a822d5b5c8545653155", "neg_random_label_ukb_s1_REP": "c2c41ddf28a303a2916dd6fa1828ac5214247f3d51a53d3bb358d73caec5daf1"}, "partition_paths": ["neg_random_label_ukb_s1_DISC", "neg_random_label_ukb_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_ukb_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d7e3c84b049f52347bc5f90bb14ee389738fadb9f51d98649467a95e066f9600", "task_id": "ncb21-task-a9c3818944cc823c"}
{"benchmark_case_id": "ncb-scientific-80318de11aee33ca", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q040", "covariates": [], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across COBRE_DISC and COBRE_REP, is the SZ-versus-HC contrast for fc_between_network directionally consistent in unadjusted dx-only group comparisons with no covariates?", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "80318de11aee33cafcafc23b40e6d185a412151c5603277794147b1d572df23d", "dataset_id": "COBRE", "discovery_cohort": "COBRE_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"COBRE_DISC": "f53b3405d06487a9d268b89165605cc0ed60d2c3a68e41f8ebe73660d9916d79", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc"}, "partition_paths": ["COBRE_DISC", "COBRE_REP"], "question_sha256": "37aff8a86a2c83db09116686490bf107792c3b5d5db511ad402b3faf268d01d8", "replication_cohorts": ["COBRE_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "86ac435effa92a0f64b37975853f1406de1ee6fe4d022ede8113f40c84ef8e63", "task_id": "ncb21-task-a9c79ca521184619"}
{"benchmark_case_id": "ncb-external-transfer-aebaac8d15a9b19e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_mci_pericalcarine_random_label_s20260738", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_pericalcarine", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_mci_pericalcarine.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3302e51001b304ed08457ae41ef9228099d2f46a58040060f91bae9929948aa1", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "78d37bf433c914a955e4cde73144e458536a774aac264d9041eaec3799be6d18", "selected_assignment_rows_sha256": "969502712f48aeb714c28de88a21a590050ef6ca6b9c7a446e19456e6f434d99"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "969502712f48aeb714c28de88a21a590050ef6ca6b9c7a446e19456e6f434d99", "discovery_seed": 20260738, "group_column": "ncb_random_group", "parent_external_claim_id": "mci_pericalcarine", "replication_seed": 21260738, "seed": 20260738, "selected_assignment_rows_sha256": "969502712f48aeb714c28de88a21a590050ef6ca6b9c7a446e19456e6f434d99", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "35e57089d90a1918400826c90111c94f69426662216c569411e8392494c6e4ec", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ee333f0bb1d61fa8656970714230e829396ceec6c4c6437f0a45b05335c3991d", "task_id": "ncb21-task-aa17d211e56c69cc"}
{"benchmark_case_id": "ncb-synthetic-stress-32a5293904ed5896", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_adhd200_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_adhd200_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_adhd200_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "32a5293904ed5896a751849e20769a216fe1880beb927b626726a62974045358", "dataset_id": "neg_random_label_adhd200_s2", "discovery_cohort": "neg_random_label_adhd200_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_adhd200_s2_DISC": "12b500d2a49884db4397172d39cccd6b3a57c374775ff7dddd0b3eb58c0407e7", "neg_random_label_adhd200_s2_REP": "f0f226e26d63d8813823a98566074791da652ef1e5e8c7d4889b50e4caf33cce"}, "partition_paths": ["neg_random_label_adhd200_s2_DISC", "neg_random_label_adhd200_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_adhd200_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a288904c5bb8a1ee0858a19c5b5699964b695181cc6ecf9100ccc9be9e600520", "task_id": "ncb21-task-ab4a5bbf4119d2a1"}
{"benchmark_case_id": "ncb-scientific-579c77d9f61e5f87", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q042", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Default-Somatomotor connectivity (fc_fc_Default_SomMot_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "579c77d9f61e5f872fb1fae891fba19835a019868aa8a7ef7a47d76233ac7b33", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "f30d58139c80f7e6f20df857bae4bb4dde60bee5b6c9b955acef51058ae22c34", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f111c2cb52ff6097222184ba87566494afc3d3adda3da29dd2fb78a7866bd834", "task_id": "ncb21-task-ab593634affa00eb"}
{"benchmark_case_id": "ncb-scientific-0c84ae301c0de1ab", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q013", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with lower Control-Default connectivity (fc_fc_Cont_Default_z), with no additional covariates, and does ADHD200_REP show the same direction?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0c84ae301c0de1abddf331f69604f3b8af8886ac64452c7b483f854ee385617a", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "9364c7f8a618b162b808f7c05ac5c450034498633f3de5ddda06072cfba642ba", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "dc7c13d757028463ea50a59f333d62281a83532b249bfd76b96a550cd6181d07", "task_id": "ncb21-task-abed0ba3d73e33a5"}
{"benchmark_case_id": "ncb-scientific-f3636d57e59fc807", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_35359026_35359026_1", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "fronto-parietotemporal-striatal functional connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 190, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded ADHD diagnosis versus healthy controls effect on fronto-parietotemporal-striatal functional connectivity in fMRI functional connectivity, using ABCD as discovery and ADHD200 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f3636d57e59fc80720979dd8e617af6796721000006447ea84631b5fed881c38", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ABCD_DISC", "ADHD200_REP"], "question_sha256": "d8c0e33c4c876b49b88db412f0cfe834ac58e89011dde47ee2d6ef793c5a9dc5", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4c6ebdb4cbe8aa75e7299a954ff9ab8a2a61fc47665f92cfe82ef22fb294b979", "task_id": "ncb21-task-abfc5beb93a7429a"}
{"benchmark_case_id": "ncb-scientific-58fd062031fc801e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q048", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Limbic_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Limbic_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "58fd062031fc801ec995be400539f15fb05609ddaa041a485e24b531f854d19c", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "62f7a6ba1b84ac1d72b8594494058212b504be14456cdb0164754364ae6e8e38", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1017ff3308a7462e450506c53e1c518e7f4c6ec547c92f6f1ad3d7ec9ba4add3", "task_id": "ncb21-task-ac0b3670d4eb0173"}
{"benchmark_case_id": "ncb-external-transfer-913498386bc29d4b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_putamen", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "SCHZ", "control": "CONTROL", "var": "dx"}, "outcome": "smri_putamen", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_putamen two_sided for SCHZ compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "913498386bc29d4b2b3c583e5816a5a09b3b17ebbe76c36fc84136301f8a9c9d", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "c9a7495fe96a9e9cd05698659acf7af038028deb67f49f51d9561829475dbdb3", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b9d779546c02e86f6ef14b71ea86b782feed43cd71748f442a139ed918b8f606", "task_id": "ncb21-task-acc2b44ef899edee"}
{"benchmark_case_id": "ncb-synthetic-stress-ce1212b806f25235", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_ukb_s1", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_ukb_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_ukb_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ce1212b806f25235e4b70df30f8c134e9cf8023b9837510e2e0fd15d0b4ae20d", "dataset_id": "neg_site_confound_ukb_s1", "discovery_cohort": "neg_site_confound_ukb_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_ukb_s1_DISC": "a483b2891909810f0041c4f81593b65640f5908c90ccff391a6b3099f4e2effd", "neg_site_confound_ukb_s1_REP": "1ab56330f28688cbba456e51b447c407bdae39a0365ff6089febbb17af4da0fd"}, "partition_paths": ["neg_site_confound_ukb_s1_DISC", "neg_site_confound_ukb_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_ukb_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "06cbebb18e5a849c3943d0f54e65bc04d2ecae54b39c4d8f2ca976b826aedee4", "task_id": "ncb21-task-accec999181659bf"}
{"benchmark_case_id": "ncb-synthetic-stress-b06c112fe652826c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_abide2_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_abide2_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_DorsAttn", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_abide2_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "b06c112fe652826cbee2235af02fba088e742c71297e691734171303d35a6d45", "dataset_id": "neg_p_fishing_abide2_s2", "discovery_cohort": "neg_p_fishing_abide2_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_abide2_s2_DISC": "f24a70cb9e44a63ad390fd909324d8bb702efdc9ebaef49584b613f149d0822d", "neg_p_fishing_abide2_s2_REP": "29ddb08e094c719f39d95f29ab4009226122437dfb36646b8d68084bd573941d"}, "partition_paths": ["neg_p_fishing_abide2_s2_DISC", "neg_p_fishing_abide2_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_abide2_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a28c3e211a47afca18c3e6d0728cc9252c2129124d89055b7c7a96c8cef3b168", "task_id": "ncb21-task-ada878720b9c7052"}
{"benchmark_case_id": "ncb-scientific-49789008a2790135", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "sz_fc_within_cobre_fbirn", "covariates": ["age", "sex", "site"], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For SZ hypoconnectivity within-network FC in fMRI-FC, using COBRE as discovery and FBIRN as replication, test the claim with expected direction negative SZ minus HC on fc_within_network and adjust for age;sex when available.", "replication_cohorts": ["FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "49789008a2790135ef34dcf22e9cca7d4c0f5d7fbda4deb5eba3ff7d6e6f9a00", "dataset_id": "COBRE", "discovery_cohort": "COBRE_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"COBRE_DISC": "f53b3405d06487a9d268b89165605cc0ed60d2c3a68e41f8ebe73660d9916d79", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a"}, "partition_paths": ["COBRE_DISC", "FBIRN_REP"], "question_sha256": "01556625a9b8ec63fe4f204a3a16d2a31f82ef736397c39bf15f966331a4eb3e", "replication_cohorts": ["FBIRN_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "722fb2d507e4c1aaeb7efe6875886478d493bfd395a00cc432097d069c3370b0", "task_id": "ncb21-task-ae4cffe1ef03c0b4"}
{"benchmark_case_id": "ncb-scientific-060910c2dae3c7c0", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_35583796_pmid35583796_rsfc_dmn_control_salience", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": ["fc_fc_Cont_Default", "fc_fc_Cont_SalVentAttn", "fc_fc_Default_SalVentAttn"], "predictor": "confirm_dx", "region_set": "dmn_control_salience_between_network_fc", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 3, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded ADHD diagnosis versus controls effect on between-network functional connectivity involving DMN, fronto-parietal control network, and salience network in resting-state fMRI functional connectivity, using ABCD as discovery and ADHD200 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 3, "selection": "preregistered"}}, "contract_sha256": "060910c2dae3c7c0bc483bb7456953e7717bc55f016c82a246c15256e99ca483", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ABCD_DISC", "ADHD200_REP"], "question_sha256": "9c735d4dc9edc40d7030cd4f4556ebf3845fcc2b93b86bd6cd8b91a15d0c66fa", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "697ba59c803d85328cce749b19fb714eeef1c0b25e15f34edbe04b2b9e12a42c", "task_id": "ncb21-task-ae6661191cc66113"}
{"benchmark_case_id": "ncb-synthetic-stress-cc6a8be21390c788", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_cross_nonrep_ukb_hcp_aging_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_cross_nonrep_ukb_hcp_aging_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_SalVentAttn_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_cross_nonrep_ukb_hcp_aging_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "cc6a8be21390c788a36b28af9e0889a99ec0413c24fe442b18de3b0e4bc83630", "dataset_id": "neg_cross_nonrep_ukb_hcp_aging_s1", "discovery_cohort": "neg_cross_nonrep_ukb_hcp_aging_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_cross_nonrep_ukb_hcp_aging_s1_DISC": "776ab3748f2c1afa6865dd9fd782938a459a1efdf81dcd8b321989268374a4ed", "neg_cross_nonrep_ukb_hcp_aging_s1_REP": "7414a1d951d0092d82522ef6313296567b5681d092c9ad40841d41912f523fad"}, "partition_paths": ["neg_cross_nonrep_ukb_hcp_aging_s1_DISC", "neg_cross_nonrep_ukb_hcp_aging_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_cross_nonrep_ukb_hcp_aging_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "db8ed68ea06bf12c85d6a92f6a67faa5f8430adac02fcd5b64f24b7457d0d4b4", "task_id": "ncb21-task-aeabe4bbbc653171"}
{"benchmark_case_id": "ncb-external-transfer-a614b9f9882504d0", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_postcentral_random_label_s20260734", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_postcentral", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_ad_postcentral.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "38047a99569b8c6d055c31fb9abf1854bfbd9362cd6d3226a4899c89e0fe2efc", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "534a807b74c05b8d257715674e938a1db27c34ee22639b4f4c65eabd3217c703", "selected_assignment_rows_sha256": "d08fa306778013fa8ba5c5956ccdfed3cc635c8278295dfe1aa9c969ab23c458"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "d08fa306778013fa8ba5c5956ccdfed3cc635c8278295dfe1aa9c969ab23c458", "discovery_seed": 20260734, "group_column": "ncb_random_group", "parent_external_claim_id": "ad_postcentral", "replication_seed": 21260734, "seed": 20260734, "selected_assignment_rows_sha256": "d08fa306778013fa8ba5c5956ccdfed3cc635c8278295dfe1aa9c969ab23c458", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "dfea690d6dd034fb03620c86b742540b961f7b6919db72dbf1cdbd02499477a7", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "44640b923250186c16620c628f181958b6df0ba09c59f53436b1641ed443a2e9", "task_id": "ncb21-task-af3e384c7e68d116"}
{"benchmark_case_id": "ncb-scientific-3942bdaedf8efb2a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q023", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_REP, is fc_within_network lower in SZ than HC in an unadjusted dx-only group comparison with no covariates?", "replication_cohorts": ["ChineseSZ_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3942bdaedf8efb2afecb3c2c12045c0014df9f189b66d0de08e09298d10c22ae", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ChineseSZ_DISC": "25886d87d5dc1da53df39d984bfa54f68aa99adbbbcb75b7d4826c4d8bdaff73", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8"}, "partition_paths": ["ChineseSZ_DISC", "ChineseSZ_REP"], "question_sha256": "45fc5a612e729a6508baf65d19a5bf36c2c8eb55cb58485f343c1b1eb135b55a", "replication_cohorts": ["ChineseSZ_DISC"], "schema_version": "2.1.0", "scientific_core_sha256": "d34baf9839a1f7ce0351893f85dc9f2c76b5229d9fe60120e79e29850b5038af", "task_id": "ncb21-task-afd8d2f90a5decce"}
{"benchmark_case_id": "ncb-external-transfer-fc18a39ffb8c66fb", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_caudate", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "SCHZ", "control": "CONTROL", "var": "dx"}, "outcome": "smri_caudate", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_caudate two_sided for SCHZ compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "fc18a39ffb8c66fb681c83d5e2c382c09f10fb5024d6d1c7f4f8b8860e260f02", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "60fe191239a61a263493aea1a1a7b286ecea8868d2e3268457dd7a2cfa4c4274", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "009244f0feaa3b134fbd991282e3c6293bc216bb4152af10feadb95a52c28797", "task_id": "ncb21-task-afff5e156656f798"}
{"benchmark_case_id": "ncb-scientific-ce5c0063d478e61d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q012", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_hippocampus", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In ADNI_DISC, among CN participants, is older age associated with lower smri_hippocampus, adjusting for sex?", "replication_cohorts": ["ADNI_REP", "OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ce5c0063d478e61da293889593af2afd1b8b29c77b2df5c7d7de1191d162c10c", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "ADNI_REP", "OASIS3_REP"], "question_sha256": "3da394c3a30e23294013cccfc65037f96a4f2d8eed9a06c86cb73d751dff11e4", "replication_cohorts": ["ADNI_REP", "OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7d494c68bdd53df5e8e4d1696c6cb9570310dcc82fe9e3a9d5833d7ab948fbe5", "task_id": "ncb21-task-b0061b835ca1457f"}
{"benchmark_case_id": "ncb-external-transfer-eaaa2769700eae0e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_bd_accumbens", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "BIPOLAR", "control": "CONTROL", "var": "dx"}, "outcome": "smri_accumbens", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_accumbens two_sided for BIPOLAR compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "eaaa2769700eae0e80a70ab4b04f2ae8fe5e524c5f43d23ef5a8e192b0b69523", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "7f994ebc658145f09bbcfb73c99b9710e8b3836d43af91fdcff20db068e71dfd", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "834b43e9135e961349f2bbc68dd0cd72ea4595535a98e5219174cd572aa2a426", "task_id": "ncb21-task-b0a7823a4e0c542b"}
{"benchmark_case_id": "ncb-external-transfer-b8fb8dbb05332d12", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_adhd_pallidum", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "ADHD", "control": "CONTROL", "var": "dx"}, "outcome": "smri_pallidum", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_pallidum two_sided for ADHD compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "b8fb8dbb05332d12269e95853428ee27fe9dc55dcc7002c27e81a5ac83b94e59", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "fa741a945b42d260005158d1cd289b0c8dd483433e9d7075274f9a62ebf84f68", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "787a185998d584ae5549e151257d494bb8047dc67ba224687b5df5b743f46410", "task_id": "ncb21-task-b0f7d6a40b5ff683"}
{"benchmark_case_id": "ncb-scientific-da99887ee1c161f8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q013", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "pet_av45", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with higher pet_av45 than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "da99887ee1c161f8ace824a8f4f353abd0b75b76e0f9cc87e3fdc1d6e2cca576", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6"}, "partition_paths": ["ADNI_DISC", "ADNI_REP"], "question_sha256": "971e0ba85bd308439b4473e5b129c205065eb077bfa7cab7d9489fdd1bf8314e", "replication_cohorts": ["ADNI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "94b82c5a937c61645989e76a195386477c181f2c9fbd0b2ffa19373518d83fa7", "task_id": "ncb21-task-b148816c3f2385a3"}
{"benchmark_case_id": "ncb-scientific-49fd02560669f081", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q022", "covariates": [], "discovery_cohort": "ChineseSZ_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_REP, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["ChineseSZ_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "49fd02560669f081865a60b8024eb81ebb6dc5834a87820f119def66b35fa233", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ChineseSZ_DISC": "25886d87d5dc1da53df39d984bfa54f68aa99adbbbcb75b7d4826c4d8bdaff73", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8"}, "partition_paths": ["ChineseSZ_DISC", "ChineseSZ_REP"], "question_sha256": "7ce52abe559cbd413fff3fb055b9a369ddda4cd1a5c293ae33a6e19ae080c5de", "replication_cohorts": ["ChineseSZ_DISC"], "schema_version": "2.1.0", "scientific_core_sha256": "db49cfc08d0dc1e0cf596335c58ce0bd7d0c5168d8ff9859c604cf2df53eaa6e", "task_id": "ncb21-task-b1e9180bbfc16c27"}
{"benchmark_case_id": "ncb-scientific-6bedac272110f713", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q004", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "confirm_dx in [\"case\", \"control\"]", "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with lower Control-DorsalAttention connectivity (fc_fc_Cont_DorsAttn_z), with no additional covariates, and does ABCD_REP show the same direction?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6bedac272110f71307ba214166242c783aaabb9d2c90371d6e25cf14b2258297", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "aafddaff6e02d26deda394069fd3fddfb42755355228d65e871f1ec7543099f9", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "176c043ea40f5f2781744b1c5ce5ad49f5ea34bde41c1a573055e15479085f69", "task_id": "ncb21-task-b223c5ff80096a89"}
{"benchmark_case_id": "ncb-scientific-7c8fd02a769bcd9a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "sz_brainwide_fc_4cohort", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For SZ brain-wide FNC dysconnectivity pattern (100-IC edge-level) in fMRI-FC, using ChineseSZ as discovery and BSNIP2;JH;BSNIP1 as replication, test the claim with expected direction two_sided distributed pattern and adjust for age;sex (no motion available).", "replication_cohorts": ["BSNIP2_REP", "JH_REP", "BSNIP_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "preregistered"}}, "contract_sha256": "7c8fd02a769bcd9a50c58371dc350ccdbc8a4ee13f120f120f0bbcd3b15a000f", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "BSNIP_DISC": "e2cdf8ee207ed53b90f28ff8ab7278739cf7239292aa2a594f87d5177859d233", "ChineseSZ_DISC": "25886d87d5dc1da53df39d984bfa54f68aa99adbbbcb75b7d4826c4d8bdaff73", "JH_REP": "f40fac0acd9aa1425552a409658e883651432d578db1db8a9c290e2ea4850ae6"}, "partition_paths": ["BSNIP2_REP", "BSNIP_DISC", "ChineseSZ_DISC", "JH_REP"], "question_sha256": "6e926668ee2102fe15bfb78e98e843358b9bd05425dc94eb7cb40b8460de631c", "replication_cohorts": ["BSNIP2_REP", "JH_REP", "BSNIP_DISC"], "schema_version": "2.1.0", "scientific_core_sha256": "f195a54175bfefe1dc78325623429d9ed0af8a9562b49d2cc5266443582b657c", "task_id": "ncb21-task-b23feae2580b6639"}
{"benchmark_case_id": "ncb-scientific-8317e3afc8d4d4c2", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_1431963_pmid1431963_mtl_linear_ad_vs_controls", "covariates": ["age", "eTIV", "sex"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": ["smri_entorhinal", "smri_hippocampus", "smri_midtemp"], "predictor": "confirm_dx", "region_set": "medial_temporal_lobe_smri", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "eTIV", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 3, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded probable Alzheimer's disease versus age-matched controls effect on medial temporal lobe linear measurements in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction two_sided and adjust for age;eTIV;sex when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 3, "selection": "preregistered"}}, "contract_sha256": "8317e3afc8d4d4c2055b23ae14d59e3a947e1930aa8a0be481f0391bdb109969", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "41619b7e7ed4b0c9f0e1bcd7b57b8fad4e5ae6eb88ea00d01e2c01be0070642f", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "9b1140527275dc94839a64072626182fe42daaf1174bec8c9e2f746f618b0400", "task_id": "ncb21-task-b297e57cca14b456"}
{"benchmark_case_id": "ncb-synthetic-stress-c220a093f814e539", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_adhd200_s1", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_adhd200_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SalVentAttn_z_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_adhd200_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c220a093f814e539c092d84cc1efe4a5a4acc8fba2aa831de51a420ec3878b57", "dataset_id": "neg_underpowered_adhd200_s1", "discovery_cohort": "neg_underpowered_adhd200_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_adhd200_s1_DISC": "a2fbe71e3412823228cb028ad7112fe23f33edf38b96f239af8616f0c9ab4c1e", "neg_underpowered_adhd200_s1_REP": "cf6bc975c0b18501d1d25eb2fad73e32729d3d294223bb50712e871f56a23ee1"}, "partition_paths": ["neg_underpowered_adhd200_s1_DISC", "neg_underpowered_adhd200_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_adhd200_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c2754acb929762e3132ba35d71c55c1e89ddd4050bf27e657a810064834a085e", "task_id": "ncb21-task-b3a7d069db546544"}
{"benchmark_case_id": "ncb-external-transfer-fc82caeab42cbb0b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_adhd_hippocampus", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "ADHD", "control": "CONTROL", "var": "dx"}, "outcome": "smri_hippocampus", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_hippocampus negative for ADHD compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "fc82caeab42cbb0ba375c7a3cb5f9955c6f293db20dd90fef6283883c8209361", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "e6d448c103f6ded476b98d67475bbc33b4e3ce95f27131ccebbe6f597a7671ca", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "16d1cf18da8dcbcfe503122ec9e9c9d495002cbddc40d471537a07e5fb047f48", "task_id": "ncb21-task-b41d1e817622f9ee"}
{"benchmark_case_id": "ncb-scientific-a7bd041be62e2db4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q031", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Limbic_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a7bd041be62e2db43aded1d76a6c0b581c7274b1f519b9d483c62e6dc39f3136", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "3e5de38ee0c91ab4b8c978611368431913f9e80f1d93980483df61e2376788ce", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "3714a41f633c1dc72807b8c293ed5379671b1fd549f8f1ef207a511c1177c621", "task_id": "ncb21-task-b44a4ec14f918682"}
{"benchmark_case_id": "ncb-synthetic-stress-cc868c07af008306", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_abcd_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_abcd_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_abcd_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cc868c07af008306e1bb3ccc991c61f157543efc2119925759b207ef90ae6d46", "dataset_id": "neg_random_label_abcd_s2", "discovery_cohort": "neg_random_label_abcd_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_abcd_s2_DISC": "41f33c1581548b8c4b9e7be53699777df3d656a6d30e9420e8e1f2c88a2a1d38", "neg_random_label_abcd_s2_REP": "761faeb285c183f7d1994671b9e8a577ca7f667041dd15c4a9d44fa43bc31d8b"}, "partition_paths": ["neg_random_label_abcd_s2_DISC", "neg_random_label_abcd_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_abcd_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a83bbade1437bd556055cdb460408252d418f56ef0355e8e4eb2bbf28732de13", "task_id": "ncb21-task-b45b691c16b306b9"}
{"benchmark_case_id": "ncb-scientific-afbfd52ab898aa8b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q046", "covariates": [], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Default_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "afbfd52ab898aa8b75058616b6193b34892bea7f7d452244ed64defafeede78a", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "8f745d620c26413a8472bc7517e775687522b7c7596773a1a7f081b30a404033", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "e44382c288c683f79d9c5767662cd33a846b2da4c2bff27e709331296bd054f8", "task_id": "ncb21-task-b4d563d354061986"}
{"benchmark_case_id": "ncb-scientific-5bbd3e8e8a1ab72c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_fc_adhd200_abcd", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 28, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ADHD case-control FC difference in fMRI-FC, using ADHD200 as discovery and ABCD as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 28, "selection": "preregistered"}}, "contract_sha256": "5bbd3e8e8a1ab72c7633d7b63be523d5be9acc9a12c37f90328b5027bff3b9f5", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c", "ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd"}, "partition_paths": ["ABCD_REP", "ADHD200_DISC"], "question_sha256": "45a53ebaaa1e06d04fefc2ec7fbfe0f5f751658ba43cb23a4a4bd4fb9c994662", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "8818fa68d83d9a447c83b30194950086218be94f32f16762aa0312a5e47d779a", "task_id": "ncb21-task-b50dee44b2695af4"}
{"benchmark_case_id": "ncb-synthetic-stress-e9fb3c58c1aaf079", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_ukb_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_ukb_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Default_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_ukb_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "e9fb3c58c1aaf079326d24fa3af86aa90235c286ded143d559f2175fdb0412d2", "dataset_id": "neg_p_fishing_ukb_s1", "discovery_cohort": "neg_p_fishing_ukb_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_ukb_s1_DISC": "54805b96956e62baf32e6b810b3a47ae7e7162cb7f2f47048b577b3b5000a783", "neg_p_fishing_ukb_s1_REP": "00fc6d55172669471120f549e5199ac748e390647bbb3d0c483ec951d3c82e0c"}, "partition_paths": ["neg_p_fishing_ukb_s1_DISC", "neg_p_fishing_ukb_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_ukb_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "34808893a64ad2ea1727d914fe5dc8b8d8b41b360e9b9427ca698d300c86aeb0", "task_id": "ncb21-task-b51d8e49c61305b6"}
{"benchmark_case_id": "ncb-scientific-0fba59d9c8075ce0", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_032", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_DorsAttn_DorsAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher age associated with higher dorsal-attention within-network connectivity (fc_fc_DorsAttn_DorsAttn_z), adjusting for sex and cognition?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0fba59d9c8075ce0e6445699e130455b749c5802904fc65688809203764277dd", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "aa573b98bf3ba778c8e663f5d9dfb744915a24230bbc71733181124f99df9f0a", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6c80d758ec23d1d160b310e551098e486628cc6532245ccf50a3db14fb713e55", "task_id": "ncb21-task-b56715660f95ba57"}
{"benchmark_case_id": "ncb-scientific-3bb5fd92cff87e34", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q039", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Cont_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3bb5fd92cff87e343d33e2cd0d6797eaf54d41cfe43a2123a8f42229247ead6c", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "3216377109631cb3e8700e5ef4e7b61b453b37799de22d813c5e133b043e979f", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "555008a59e88bc9bcd4c307543efe03626eadc2c7812cd3b22a23248c5c0b1a2", "task_id": "ncb21-task-b56a70f7ddd5fc44"}
{"benchmark_case_id": "ncb-scientific-4ffc0faff41b9d25", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q025", "covariates": [], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In FBIRN_DISC, is SZ associated with lower fc_mean_positive than HC in an unadjusted dx-only group comparison with no covariates?", "replication_cohorts": ["FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "4ffc0faff41b9d251ae15c86a5646175e1972970df38a88ccfac126ba34f43b9", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"FBIRN_DISC": "5a9a103412824c97ff34a4b7c9107198e9309be14f345c917761eb11adcdbd82", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a"}, "partition_paths": ["FBIRN_DISC", "FBIRN_REP"], "question_sha256": "d13d2b62913f5c098393f517d74d2046a445696c24b0bcdfeca33e9db9372ee9", "replication_cohorts": ["FBIRN_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fe7ca606cc15152226741e3c17bc7df83318a04ec3ecb53c6b3c26fc091a2ad7", "task_id": "ncb21-task-b578c3c76fe3269c"}
{"benchmark_case_id": "ncb-synthetic-stress-c2d028849e27a38a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_hcp_aging_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_hcp_aging_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_hcp_aging_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c2d028849e27a38a4163727fd41a1d0447400ecbd226af40cb963c1e4d4b2d1b", "dataset_id": "neg_random_label_hcp_aging_s1", "discovery_cohort": "neg_random_label_hcp_aging_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_hcp_aging_s1_DISC": "9becda9f2ffb8e2d9ac43f0e31a29b2656c02cea02cb8ea30a79be7014936c96", "neg_random_label_hcp_aging_s1_REP": "4d7f1c0951bcf6dc153d86ef305b55d7962e3f7418e31533de4df39334434de1"}, "partition_paths": ["neg_random_label_hcp_aging_s1_DISC", "neg_random_label_hcp_aging_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_hcp_aging_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "9818707fb1e73b3fb59dbe286cb675e73741c3907af0d4deedf7ee44635e0fad", "task_id": "ncb21-task-b6748553af1a76fa"}
{"benchmark_case_id": "ncb-synthetic-stress-064719283da9679c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_oasis3_s3", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "neg_site_confound_oasis3_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_hippocampus", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_oasis3_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "064719283da9679ced5bd065909fa8877cd1b4852ca9b0a39db376c83c19765e", "dataset_id": "neg_site_confound_oasis3_s3", "discovery_cohort": "neg_site_confound_oasis3_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_oasis3_s3_DISC": "3545c1258bd88e9065d019db672250d3409a5d5f0f57e0dee0beeb920fe16531", "neg_site_confound_oasis3_s3_REP": "78dd4f15d488eca817aa9dffff888532260dcbdba10e23c426c95adbddf9c923"}, "partition_paths": ["neg_site_confound_oasis3_s3_DISC", "neg_site_confound_oasis3_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_oasis3_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d21951525df5a92d120197b54d999082a1a0fe85e4be85f678ca30da66658403", "task_id": "ncb21-task-b691ac42ecffb6ff"}
{"benchmark_case_id": "ncb-synthetic-stress-d916964e92a59eb0", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_hcp_aging_s3", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_hcp_aging_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_hcp_aging_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d916964e92a59eb074ac5632729bf8335429ed7626a4ce4a376bbb1ebb491302", "dataset_id": "neg_site_confound_hcp_aging_s3", "discovery_cohort": "neg_site_confound_hcp_aging_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_hcp_aging_s3_DISC": "fd1e7d0baf20f3419800393db1c7914236cf1a7333d859ddc9d4955871cf9296", "neg_site_confound_hcp_aging_s3_REP": "822c14f60e9706f17370140ed96fd51123fd5e7f31b424fd2c2372eadcf059d1"}, "partition_paths": ["neg_site_confound_hcp_aging_s3_DISC", "neg_site_confound_hcp_aging_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_hcp_aging_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "79cb602fcdc0fcd8103b82cacc97790b4bfa36d32c8d68c1e712f54a89c34974", "task_id": "ncb21-task-b6f4ac28d2b3979a"}
{"benchmark_case_id": "ncb-synthetic-stress-f8423e8ba6d67c54", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_abide2_s1", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_abide2_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_abide2_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f8423e8ba6d67c54af96dcc3701b744e672c09a09a66aaf53bd2cb3a2f2a61d1", "dataset_id": "neg_site_confound_abide2_s1", "discovery_cohort": "neg_site_confound_abide2_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_abide2_s1_DISC": "dd1903f3fa0888bbdd8b92e753e18c654b40c45ae32c46a995a25dda3c8c8658", "neg_site_confound_abide2_s1_REP": "baa1bcbf6b1340d6224d7791735ab06da8209a0aaf040051c1826d758673a092"}, "partition_paths": ["neg_site_confound_abide2_s1_DISC", "neg_site_confound_abide2_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_abide2_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "552060e3291c560a719430bbfcd37fee39b091749c3d40e2a3e378e1882479b1", "task_id": "ncb21-task-b83c81d3f7ed2148"}
{"benchmark_case_id": "ncb-scientific-5b0717b45335d600", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q010", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SomMot_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "confirm_dx in [\"case\", \"control\"]", "question": "In ABCD_DISC, excluding missing dx, do ADHD cases (dx=1.0) show higher Visual-Somatomotor connectivity (fc_fc_SomMot_Vis_z) than controls (dx=0.0), with no additional covariates, and is the direction consistent in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5b0717b45335d600cb9bb3a3365f50480541f74ab04b95723d2b163524b995c2", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "6b5bdc4dddbee3b792e9544c0d98105f01a2b90cb96925c69cbebf7cafd9626f", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f1668e2649063716355784a7471b7346154ae8d358180e7a5804c681aebb6cad", "task_id": "ncb21-task-b8602e973f42b46b"}
{"benchmark_case_id": "ncb-scientific-3cd280f660dfbcd4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q004", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_DISC, do SZ and HC participants differ in fc_between_network in an unadjusted group comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3cd280f660dfbcd415a0ac5f54af96f2ce8fe1cc897a4a14f869e1ea54467213", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23"}, "partition_paths": ["BSNIP2_DISC", "BSNIP2_REP"], "question_sha256": "0960ebd7c899621d0dff9af5d9c0b550295e3b9d0284eb626fb35be6b52689de", "replication_cohorts": ["BSNIP2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f555ea3e77e68e7c98be57a506ff641953f2f8e879082a91e5d6b59613b497bb", "task_id": "ncb21-task-b93848fb1885ade6"}
{"benchmark_case_id": "ncb-scientific-a02841671504d8cd", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q029", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_Limbic", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Limbic_Limbic differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a02841671504d8cd91f7002bbbc87782b0cb75c4c91c3c75f40930bf0fc27467", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "cbd2d211c6dc6de80c4b9f18ade9709f22962b3b4c1fb13e66f334359e7003ef", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5293f7fc3fbd61338fa219ef1478adf4aa6b2fab233abcddcc55abe72e446a44", "task_id": "ncb21-task-b95b16ef9794f281"}
{"benchmark_case_id": "ncb-synthetic-stress-c0127a06d407afa7", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_adni_s2", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_random_label_adni_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_entorhinal", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_adni_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c0127a06d407afa7fd647c645835bde7b47ee103caa02110dc884452721e54ad", "dataset_id": "neg_random_label_adni_s2", "discovery_cohort": "neg_random_label_adni_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_adni_s2_DISC": "b9043a8a7298952ed96a245f4d94d184fec852f03260ae4bef3ac4c60e639c6e", "neg_random_label_adni_s2_REP": "66b05bfab5c32139ec526510326a003ea11f85ae1eeaaa9dc278490baad19f18"}, "partition_paths": ["neg_random_label_adni_s2_DISC", "neg_random_label_adni_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_adni_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "11086c9a5c8c9bdcad375a1b23ec12e06f5b5e4f0fbf8dedb0a8e91b486b5ff5", "task_id": "ncb21-task-b9861c2208ee43af"}
{"benchmark_case_id": "ncb-external-transfer-449e7b4f8e2900f2", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_mci_entorhinal_random_label_s20260731", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_entorhinal", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_mci_entorhinal.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "b438e68421f62598f6144a98276d5070cf53e61708b4ffaeca54f0db418f9a10", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "a2585a1e1422c9154549b2d510e39a14cff4a28ac02bcfd26d2a0e9886533d0a", "selected_assignment_rows_sha256": "c2d9f3cbc89fc309c546ea9278de0e834b01102d35e823f455bea814e5a89565"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "c2d9f3cbc89fc309c546ea9278de0e834b01102d35e823f455bea814e5a89565", "discovery_seed": 20260731, "group_column": "ncb_random_group", "parent_external_claim_id": "mci_entorhinal", "replication_seed": 21260731, "seed": 20260731, "selected_assignment_rows_sha256": "c2d9f3cbc89fc309c546ea9278de0e834b01102d35e823f455bea814e5a89565", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "f7e67ab2c56e8e9a6c4c064c877de70de70c020630843e20a3199a87dbb480d6", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "51e0e3aa9ad140eef7727e0f8c8d8b148a4271ddc92b32d2b9da958b9a9b0b1c", "task_id": "ncb21-task-b98bf983ead6f362"}
{"benchmark_case_id": "ncb-scientific-09bce8d2747a588b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q020", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Limbic", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_Limbic differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "09bce8d2747a588b48e78179d64eef021ef591c62d258c96db87fa1a187763be", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "84af72908c7b8f321c78d60aac374797544378b154f67c119a75696f810078ef", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fab01154d6c71c30855e10af8840ebc9d8582145c4279bcd7cf1d879064faf5e", "task_id": "ncb21-task-ba5da3b4e0cc513f"}
{"benchmark_case_id": "ncb-external-transfer-bd91d6374d028fa2", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_hippocampus", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_hippocampus", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_hippocampus negative for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bd91d6374d028fa2b0bb5214ffa478877487a12d7b56cf7a495d42c306ac0d99", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "7d6f3bbc1c0664e8ee14229ef41c27e1d9a65e696ce299470f12eab5fde10c33", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f09597fa2d0a1347d0476aeeea0c563fa1b7538f251fe786995619ca28390fe6", "task_id": "ncb21-task-baa1113679fb1a86"}
{"benchmark_case_id": "ncb-external-transfer-9345083b10556ec3", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_cuneus_random_label_s20260736", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_cuneus", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_ad_cuneus.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "236d9e863eca8dbbec9a7a6666c1537b22dcdd7218f3dabcdc6a0f59e0bf8511", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "ad610de1f038db3ae015018e137ce47c09095cf6e925c8bcec23cb008423d410", "selected_assignment_rows_sha256": "fe8bbba7a16dae90738b66d4cbbe477e41e68e07419db04bb44cb960de6be887"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "fe8bbba7a16dae90738b66d4cbbe477e41e68e07419db04bb44cb960de6be887", "discovery_seed": 20260736, "group_column": "ncb_random_group", "parent_external_claim_id": "ad_cuneus", "replication_seed": 21260736, "seed": 20260736, "selected_assignment_rows_sha256": "fe8bbba7a16dae90738b66d4cbbe477e41e68e07419db04bb44cb960de6be887", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "506d430c1bbc4c4de013342e4a78c10bb7664e60c242cee4cf970c568fe960ef", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f6d73ee9ef588c5c088f47f87a355e37f96b0f74b5e865b6381123779d4d6ca8", "task_id": "ncb21-task-bb43c3c406fa97cf"}
{"benchmark_case_id": "ncb-external-transfer-d502bc59cbfea3cf", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_cuneus", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_cuneus", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_cuneus negative for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d502bc59cbfea3cf8cda2d29aef62fb06b7709f7e48d6ecb66faf313115e21ec", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "b1263d85f4a560761c142f4cbe87c3c7fe87a88df26e1f3ef14fecb1f22dcb85", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "688ccd279b59e939f2c7d8b770f14658abc8c921a5f75714488f63db12f578c8", "task_id": "ncb21-task-bb554719e6145756"}
{"benchmark_case_id": "ncb-synthetic-stress-b3381266246ed676", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_abcd_s2", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_abcd_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_abcd_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "b3381266246ed6768c1876531551c6e6414b450416449c633bc84f40105ef819", "dataset_id": "neg_underpowered_abcd_s2", "discovery_cohort": "neg_underpowered_abcd_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_abcd_s2_DISC": "54cf149b1eb811d2e15e5cead800ef7cfe9eac0553a8dd6796e11f3e196ca679", "neg_underpowered_abcd_s2_REP": "ee791ec38ca3fbf6e2111916c096055ba075c694b6e0b5f764a694498434905a"}, "partition_paths": ["neg_underpowered_abcd_s2_DISC", "neg_underpowered_abcd_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_abcd_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4e7714468a10447c7c3cfe04a886c70f0068b5e0e493c0711ce8e5851460b587", "task_id": "ncb21-task-bc0d1ec559619a68"}
{"benchmark_case_id": "ncb-synthetic-stress-8969417a2a5f8ec6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_cross_nonrep_abide2_abcd_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_cross_nonrep_abide2_abcd_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Limbic_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_cross_nonrep_abide2_abcd_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "8969417a2a5f8ec645320b5f20d3f5974896a502b58158fac9e1bfc9d7e01e40", "dataset_id": "neg_cross_nonrep_abide2_abcd_s2", "discovery_cohort": "neg_cross_nonrep_abide2_abcd_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_cross_nonrep_abide2_abcd_s2_DISC": "0e9545e76aa369bb902ddb1eb59bc9d69a9a1db24e5a984e43d92f6e1bb9638b", "neg_cross_nonrep_abide2_abcd_s2_REP": "caee76faba54a99758ba260215b2499699640e98bb3e63c6de88730fa460c8e3"}, "partition_paths": ["neg_cross_nonrep_abide2_abcd_s2_DISC", "neg_cross_nonrep_abide2_abcd_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_cross_nonrep_abide2_abcd_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1b9eca0a0494a48ee8bd24227f70a0fc2282b50de13c5c20ca402f7868ff314b", "task_id": "ncb21-task-bc5b5fc4a73e8a67"}
{"benchmark_case_id": "ncb-synthetic-stress-df080a369be8d182", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_oasis3_s2", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "neg_site_confound_oasis3_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_fusiform", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_oasis3_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "df080a369be8d182b5c17d17da6f0be9a4a3ca1b68ce46960a569049932c64eb", "dataset_id": "neg_site_confound_oasis3_s2", "discovery_cohort": "neg_site_confound_oasis3_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_oasis3_s2_DISC": "827c740cad4142dd74a6570d4f7987cb880e3b6c1e7ee1f7b7726b5b26565ba0", "neg_site_confound_oasis3_s2_REP": "5225eb2d17c543e68dbe85222f1cbd4e5cf66a82204ad6e5e6752ba004faa662"}, "partition_paths": ["neg_site_confound_oasis3_s2_DISC", "neg_site_confound_oasis3_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_oasis3_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7a3c877565c5c3226795559311a8334baf59b754d08fdf3921aa7f31d5dabaec", "task_id": "ncb21-task-bd61926979c12c74"}
{"benchmark_case_id": "ncb-scientific-ed8eabb252714493", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q048", "covariates": [], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across FBIRN_DISC and FBIRN_REP, is the SZ-versus-HC contrast for fc_between_network directionally consistent in unadjusted dx-only group comparisons with no covariates?", "replication_cohorts": ["FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ed8eabb252714493617a23875b640f41f1af8d9b8826cdbb8845c317adcbc72f", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"FBIRN_DISC": "5a9a103412824c97ff34a4b7c9107198e9309be14f345c917761eb11adcdbd82", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a"}, "partition_paths": ["FBIRN_DISC", "FBIRN_REP"], "question_sha256": "b07f572602f33554042fa619304fc36928b16e01f1e6621a082cef58280e951e", "replication_cohorts": ["FBIRN_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4b1e50cc2a3c73af7604895fc456c4766a2f11d590578051e8437843213b29c5", "task_id": "ncb21-task-bdd3e3934c5e73da"}
{"benchmark_case_id": "ncb-scientific-41408a5127ecaa01", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q043", "covariates": [], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across ChineseSZ_DISC and ChineseSZ_REP, is the SZ-versus-HC contrast for fc_within_network directionally consistent with lower values in SZ in unadjusted dx-only group comparisons with no covariates?", "replication_cohorts": ["ChineseSZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "41408a5127ecaa01bb16f33bb137977cb589300803b75207c17804f34de42e00", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ChineseSZ_DISC": "25886d87d5dc1da53df39d984bfa54f68aa99adbbbcb75b7d4826c4d8bdaff73", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8"}, "partition_paths": ["ChineseSZ_DISC", "ChineseSZ_REP"], "question_sha256": "acd99d52fb45c9fbec061999b8946a1c463eed51edefb93a00c1300d54610bc2", "replication_cohorts": ["ChineseSZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d3617af993f9850718a5ecaf13969aed2425799aba29739fcd97a43f5a296c7d", "task_id": "ncb21-task-be3fb7338da2dc8b"}
{"benchmark_case_id": "ncb-scientific-6130b7ec9d114c16", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q028", "covariates": [], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In FBIRN_DISC, do SZ and HC participants differ in fc_between_network in an unadjusted dx-only group comparison with no covariates?", "replication_cohorts": ["FBIRN_REP", "BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6130b7ec9d114c162d53c779a173cc930024074dfc2f729afa0cd4fc7c5e3827", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_DISC": "5a9a103412824c97ff34a4b7c9107198e9309be14f345c917761eb11adcdbd82", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "ChineseSZ_REP", "FBIRN_DISC", "FBIRN_REP", "Olin_SZ_REP"], "question_sha256": "d40b471f39d3f359ec9a43c6dbba7db2c2ecbf620038ab06d3d5c2d59be6edcc", "replication_cohorts": ["FBIRN_REP", "BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d5f7a148dbdb909ed1e20a8310ac007e878cf9b8f3d35a9774bc0ff4f207043f", "task_id": "ncb21-task-be735a5c5e04df19"}
{"benchmark_case_id": "ncb-synthetic-stress-61a83b2df86312b4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_abide2_s2", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_abide2_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_abide2_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "61a83b2df86312b44fa182cadf64e7b04455fa04f0c9fb62a3cbec3ec1cb334a", "dataset_id": "neg_site_confound_abide2_s2", "discovery_cohort": "neg_site_confound_abide2_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_abide2_s2_DISC": "a48ef5f537634b8932a2f6b5969160b5a634373518583021aed9707a706b8b9b", "neg_site_confound_abide2_s2_REP": "065f557b3443a3f26a8ad2ce7ed708bcf0f20c3b0d636fc56f41a26cf7453df1"}, "partition_paths": ["neg_site_confound_abide2_s2_DISC", "neg_site_confound_abide2_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_abide2_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "bd6b0750f47a9f86e3be83c7c97c73b517c189d4d23a0db9569374aaaf5a4cbb", "task_id": "ncb21-task-be860de1c1e17eea"}
{"benchmark_case_id": "ncb-scientific-f143dbf87a77594f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q043", "covariates": ["sex", "site"], "discovery_cohort": "OASIS3_fMRI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_Default_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0\"", "question": "In OASIS3_fMRI_DISC, among participants with diagnosis code 0, is older age associated with lower fc_fc_Default_Default_z, adjusting for sex?", "replication_cohorts": ["OASIS3_fMRI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f143dbf87a77594f45f0c498342b2f4b17215390bf78679a21770bcc782da655", "dataset_id": "OASIS3_fMRI", "discovery_cohort": "OASIS3_fMRI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_fMRI_DISC": "7b701bee5bf1a2e4ded9c29c25ca16bc6ef6980169d9873326b362e29ecfa14d", "OASIS3_fMRI_REP": "b3ca261941658ec5a84c1f6f268e2261777e1bcd23bf28c7d2abe42d646aa786"}, "partition_paths": ["OASIS3_fMRI_DISC", "OASIS3_fMRI_REP"], "question_sha256": "bbf6ce17f877d6799d5fd59d11b01b3529c05a2439aeb61b1c01872259a184b8", "replication_cohorts": ["OASIS3_fMRI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "0714393b69960662703541921f203314c4a8b6aaf659a205cda6bb52ebee30fe", "task_id": "ncb21-task-bed2c3bc8ea49212"}
{"benchmark_case_id": "ncb-synthetic-stress-096741f8365b47ec", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_adhd200_s1", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_adhd200_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_adhd200_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "096741f8365b47ecb19243e6f39369963b57310b3868f7a6695b52afb135005c", "dataset_id": "neg_site_confound_adhd200_s1", "discovery_cohort": "neg_site_confound_adhd200_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_adhd200_s1_DISC": "d0357ef9ee3bf5c82753f05bc852dbbd3a3641ac832d16de480e8bda0e53ec74", "neg_site_confound_adhd200_s1_REP": "9eb879561214bd78301355f4dfcb9d2c87dde594a780026bbb8c807feec68c38"}, "partition_paths": ["neg_site_confound_adhd200_s1_DISC", "neg_site_confound_adhd200_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_adhd200_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "20bb58f90bbf73c2c07e0b26f3841c8057b7a1077762c36e08c88b168f6bea87", "task_id": "ncb21-task-c10905f83a2b5a38"}
{"benchmark_case_id": "ncb-scientific-5d4734ea98c9d333", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q047", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_DorsAttn_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5d4734ea98c9d333507a8f256c939d4c32820705161302d7f9b6dece95787e70", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "e0532ef3d83af02c4b647c4e7dd24b14da5fa4f67b4c8228773cb5ba9bf556ff", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a39f3a02eebe062c2ff4dac382f74ecb609e2c30755e1a7a57d821fb10c8d871", "task_id": "ncb21-task-c1d31cf0f21d21b0"}
{"benchmark_case_id": "ncb-external-transfer-2ef4c0bcc46bed37", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_amygdala_random_label_s20260742", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_amygdala", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_cnp_scz_amygdala.", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "afede2371ee08acf4ebe70e2cc5ef0a6530e8aa525e66d2c4f67e7387b8c8388", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "565cf6983dd0c73bfdf671fd20f0ac91642c7d641209f45334d849a898dc5f98", "selected_assignment_rows_sha256": "2de014c704d5735cf9919ce54868b83beb0d417f261eb2604d594643302f4853"}, "generator_spec": {"assignment_count": 265, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "2de014c704d5735cf9919ce54868b83beb0d417f261eb2604d594643302f4853", "discovery_seed": 20260742, "group_column": "ncb_random_group", "parent_external_claim_id": "SCZ_amygdala", "replication_seed": 21260742, "seed": 20260742, "selected_assignment_rows_sha256": "2de014c704d5735cf9919ce54868b83beb0d417f261eb2604d594643302f4853", "type": "independent_random_group_labels"}, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "8ff1ca3db31b406c023cfdc9de001993238a7742fecf3f4f7e6de799583a1d08", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "28001d5fb214dc8a2e59292b105dd753db11f68f959e2392f89347212736fc69", "task_id": "ncb21-task-c26251ebfb435372"}
{"benchmark_case_id": "ncb-scientific-611e67de29172a34", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q031", "covariates": ["age", "sex", "site"], "discovery_cohort": "FBIRN_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In FBIRN_REP, is fc_within_network lower in SZ than HC in an unadjusted group comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "611e67de29172a34127865843ed7fbb0a3c674cbea476eacda530d3d8c5a9abf", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "question_sha256": "83f61ceb13a1f77475c2bafa9ca9a6ce4041c1d2c98a28e1cd7fd503422ef111", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fed36af8583bc05b8a84fd38a7299acbb0033fe255d20701d5a660daacef9695", "task_id": "ncb21-task-c2e929cb5553adf2"}
{"benchmark_case_id": "ncb-scientific-e59458cf873b37f4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_hippocampal_atrophy_adni_oasis3", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_hippocampus", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For AD hippocampal atrophy in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e59458cf873b37f444e003d8a14a9e20dcedbee238f1b165ec909b1e8b57abe8", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "a272797c98c16f6bad72d38eec4f74a57ed3e8a0d23d4f4f052e1e48be3f5b38", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d0b6b8c219d458c68ca3b6a197245ee4d8a65b4b971488d03ed6e84eff5bf700", "task_id": "ncb21-task-c2ee1c5133d1ee46"}
{"benchmark_case_id": "ncb-external-transfer-6a1fd39ef4326482", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_accumbens_random_label_s20260744", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_accumbens", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_cnp_scz_accumbens.", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "73747f0cddc3039ef2f721bcbb1f7c47c6c634c7bc996bbaa9edc229f715aefb", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "9ac70ad4240af8346af65733146edf49f5716732676a155b3b9c4bb9478bf765", "selected_assignment_rows_sha256": "3590077807bb57e134fc47521443384584a574fbfe923589150dea7a09430d3d"}, "generator_spec": {"assignment_count": 265, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "3590077807bb57e134fc47521443384584a574fbfe923589150dea7a09430d3d", "discovery_seed": 20260744, "group_column": "ncb_random_group", "parent_external_claim_id": "SCZ_accumbens", "replication_seed": 21260744, "seed": 20260744, "selected_assignment_rows_sha256": "3590077807bb57e134fc47521443384584a574fbfe923589150dea7a09430d3d", "type": "independent_random_group_labels"}, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "c3f329ae2cc3045109c5a6c3051b95fb3d9edb309895ea869b08896d5cd32f40", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "aa31bdaf2f0dccdda63f8b1de9fd04233c8402f180b7f5116fa6f090c43b60f7", "task_id": "ncb21-task-c3101591e4f28500"}
{"benchmark_case_id": "ncb-scientific-1c1c6743a2aa1468", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_dyno_adhd200_abcd", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "raw_fmri_dyno_", "predictor": "confirm_dx", "region_set": "fmri_dynamics", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 30, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ADHD case-control fMRI dynamics difference in fMRI-dynamics, using ADHD200 as discovery and ABCD as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 30, "selection": "preregistered"}}, "contract_sha256": "1c1c6743a2aa1468c93471f6988cf5936bf1fb3c13e4c18b848baf0a07b06338", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c", "ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd"}, "partition_paths": ["ABCD_REP", "ADHD200_DISC"], "question_sha256": "f19f3c6e8e272e3ddeceed3b9fb2295a0c311583fb57009972a182a05ba2e34c", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5594d6e3625f5ef4319d909bf8303c9d2db04725a00a353d8a20e33db834439a", "task_id": "ncb21-task-c3310379971f41e3"}
{"benchmark_case_id": "ncb-scientific-9066c4a0d3bc2f9f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q016", "covariates": ["age", "sex", "site"], "discovery_cohort": "COBRE_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_REP, do SZ and HC groups differ in fc_between_network in an unadjusted comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9066c4a0d3bc2f9f335adcc9e6fce3653c8c38198faedd03436f1aa34da54b25", "dataset_id": "COBRE", "discovery_cohort": "COBRE_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc"}, "partition_paths": ["BSNIP2_REP", "COBRE_REP"], "question_sha256": "5b3efc83c2238eab3df9ed2b7c3e5db350519871fbc673eb52d4bdcd615604b3", "replication_cohorts": ["BSNIP2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b8816d7b8cba0591f711b2a1ef077b7ba86ef2516c8096b77eaf0c9a64bbc9e1", "task_id": "ncb21-task-c356c0495b8f5c1e"}
{"benchmark_case_id": "ncb-external-transfer-c4f5cafd4fc66d6e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_lateralventricle_random_label_s20260729", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_lateralventricle", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_ad_lateralventricle.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0de4e0b71532da554422a891dd54ed5d6985a6f233586a6d545aa5ba3e0b57b6", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "fc4a75eb49aec40986665729a504f19e33b1e97745fa2457ac65ae8b2c15cecd", "selected_assignment_rows_sha256": "570d73e337e7316eab12c50fbf71cac6a5c970dd88f5927bac9edeaac0d609a8"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "570d73e337e7316eab12c50fbf71cac6a5c970dd88f5927bac9edeaac0d609a8", "discovery_seed": 20260729, "group_column": "ncb_random_group", "parent_external_claim_id": "ad_lateralventricle", "replication_seed": 21260729, "seed": 20260729, "selected_assignment_rows_sha256": "570d73e337e7316eab12c50fbf71cac6a5c970dd88f5927bac9edeaac0d609a8", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "a3cfaf6f116ca3b89ff9e9be919670aa8d21348b6b22a0f9e937ec2c5d21e713", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4ddb4c96ee811cf1fd205c29ce026c0c0675158164d8894dbf864f7e52b89aee", "task_id": "ncb21-task-c47957b26806a895"}
{"benchmark_case_id": "ncb-scientific-7f4258667f94f44d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q027", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_hippocampus", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In OASIS3_DISC, among CN participants, is older age associated with lower smri_hippocampus, adjusting for sex?", "replication_cohorts": ["OASIS3_REP", "ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7f4258667f94f44d5e73e949aab05c8374dbe1ac010e146956307f30d3201ba2", "dataset_id": "OASIS3", "discovery_cohort": "OASIS3_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6", "OASIS3_DISC": "8a048aaff562775d7c80f7027c9d8bb56cc738b7563d25ca06af7cb33df89d31", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_REP", "OASIS3_DISC", "OASIS3_REP"], "question_sha256": "e08530a1ce66821e0185b99544e99b7af362c6c7ec77a4a3089fb24d52bb2103", "replication_cohorts": ["OASIS3_REP", "ADNI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "366fb3b38fdadfe5baaa3273d0ba2c983d3068cfecb137d67dc4668c1c965265", "task_id": "ncb21-task-c56dc7c61f203feb"}
{"benchmark_case_id": "ncb-synthetic-stress-58807756a4b61455", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_hcp_s3", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_hcp_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_hcp_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "58807756a4b61455fbcbdc556a22ba4aba8dd58127da5f2ba91b33e7e523c187", "dataset_id": "neg_site_confound_hcp_s3", "discovery_cohort": "neg_site_confound_hcp_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_hcp_s3_DISC": "af887de8220eff84424d140330b0b4f8ee660f91ec2dd07088377729cd5c57f0", "neg_site_confound_hcp_s3_REP": "92e106241e84ac52f68ef138909f6cc1a94f60a04c6ec5bd6ec8e411ba4b4c3e"}, "partition_paths": ["neg_site_confound_hcp_s3_DISC", "neg_site_confound_hcp_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_hcp_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "31a2eedfb75b0b0702dffa390b1e3f8cc6bfa8b22df4cc48ea863469897bc4b6", "task_id": "ncb21-task-c6df24464e7071d9"}
{"benchmark_case_id": "ncb-scientific-a9e0ba33a876abc0", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_007", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_SomMot_SomMot_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with lower somatomotor within-network connectivity (fc_fc_SomMot_SomMot_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a9e0ba33a876abc0fa6cbc657ebbfa5b3516bdf998288dcb9ea497f1dd12cfda", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3", "UKB_REP": "6da6a67cb610290a28f97b077dd2aa0e82c39161e4b3c622857cb54843df2357"}, "partition_paths": ["UKB_DISC", "UKB_REP"], "question_sha256": "633cfc5e33b7c5e69d55f47588bbc479674deee1e1de7216ce7490d6119c6bc2", "replication_cohorts": ["UKB_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "42753116d455ebd0fa4e5f85e303ac4e3504e22301918cfa510a3edcb016fc51", "task_id": "ncb21-task-c781fd15ae8248cb"}
{"benchmark_case_id": "ncb-scientific-2f6ce6fa5ea95eeb", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q026", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_SalVentAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2f6ce6fa5ea95eeb785ac239b4ff56b118d9d5b5b0e1c76df4fda92bdb52f08c", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "1cc181ed04ce94ae3a8a35cef9226410210ba71a00ccbecba42601ce195129e9", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "54d4ece16eec4e787c8b8c66a96b963b0a5ca6a5fef506a99c232adfc0fef0ab", "task_id": "ncb21-task-c8004841f6d71d20"}
{"benchmark_case_id": "ncb-scientific-7be5e0886589fedd", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_019", "covariates": ["age", "phen_fluid_composite", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Limbic_Limbic_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, do females and males differ in limbic within-network connectivity (fc_fc_Limbic_Limbic_z), adjusting for age and cognition?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7be5e0886589fedd176d8f8a4351a86533239f8929f35db4651ba564298bca62", "dataset_id": "HCP", "discovery_cohort": "HCP_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["HCP_DISC", "HCP_REP"], "question_sha256": "530e5c21bfc8d9fae437f44614c53c11ecbb23847a4503ce32eeea8747378e71", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "59b5fc6addd3e1e598a2e191a53f7349a2d8c9ea524c43da926a8f0f8d09ce57", "task_id": "ncb21-task-c876031a0856d8ed"}
{"benchmark_case_id": "ncb-scientific-172d75bcc17dcce9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q046", "covariates": [], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across FBIRN_DISC and FBIRN_REP, is the SZ-versus-HC contrast for fc_mean_abs directionally consistent in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "172d75bcc17dcce9c2a8cde3b446b4521935e40d9bee3691b4d574e1b426012d", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"FBIRN_DISC": "5a9a103412824c97ff34a4b7c9107198e9309be14f345c917761eb11adcdbd82", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a"}, "partition_paths": ["FBIRN_DISC", "FBIRN_REP"], "question_sha256": "801d163072ac548006b03fd8eaa0ff97f01d380f90e7d7c5d906ac4deffc9b43", "replication_cohorts": ["FBIRN_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "68f3e3d6b4329417016b6e28cd3a86be4825bfc6d274d17e8ab55b07cb302b52", "task_id": "ncb21-task-c8829f53c8dd90c9"}
{"benchmark_case_id": "ncb-external-transfer-21a9351a0c613d68", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_putamen_random_label_s20260748", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_putamen", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_cnp_scz_putamen.", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "65b1b4ecc86db12071e7bd911838358945c5c42d9f1573c3c3611f7edcc546fe", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "47e473a5463f77f903239222413914e7c52bb0ee16c58f6be7d9e59c5c1c3d18", "selected_assignment_rows_sha256": "e88def7af772866d75075b6d91e66461a44c6dac6b34d0cb22faca6784504f51"}, "generator_spec": {"assignment_count": 265, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "e88def7af772866d75075b6d91e66461a44c6dac6b34d0cb22faca6784504f51", "discovery_seed": 20260748, "group_column": "ncb_random_group", "parent_external_claim_id": "SCZ_putamen", "replication_seed": 21260748, "seed": 20260748, "selected_assignment_rows_sha256": "e88def7af772866d75075b6d91e66461a44c6dac6b34d0cb22faca6784504f51", "type": "independent_random_group_labels"}, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "1138deee7c35c43d3586d6d64a3dabb1e462c2e7f28af2a990f530490c6561f5", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d66b4231ce36ea72ee751d1afed648de356bfe42654aa3df9fffc37706cc6987", "task_id": "ncb21-task-c8efa5ce726d2a2c"}
{"benchmark_case_id": "ncb-scientific-792968836011440a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q005", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_midtemp", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with lower smri_midtemp than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "792968836011440afaa2e9f79b4c506d6dbabdb10a3878b0c91aa60f7e6ca696", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6"}, "partition_paths": ["ADNI_DISC", "ADNI_REP"], "question_sha256": "288133858c3adbbc647a71463b288b7a5482b4d8987b04546936f7b45de44d12", "replication_cohorts": ["ADNI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "932639475f875c136afd0628e9ba6621e6a676ad5335136185f9152ce0a5e9ff", "task_id": "ncb21-task-c960d04f2a3a502e"}
{"benchmark_case_id": "ncb-synthetic-stress-3b26f2bc31391570", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_oasis3_s2", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_p_fishing_oasis3_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_midtemp", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_oasis3_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 6, "selection": "discovery_only"}}, "contract_sha256": "3b26f2bc313915707cce1961fe78a504241e90333eb65c18a0d833f991dc5f1d", "dataset_id": "neg_p_fishing_oasis3_s2", "discovery_cohort": "neg_p_fishing_oasis3_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_oasis3_s2_DISC": "9e3181de82d249843e28db30312c7480581dfecf6367b71c0bb5ed6b74f30c37", "neg_p_fishing_oasis3_s2_REP": "a8eec638f3f7d38158d610bf94784264d840461fbbdeee1d3cef641124686849"}, "partition_paths": ["neg_p_fishing_oasis3_s2_DISC", "neg_p_fishing_oasis3_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_oasis3_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "67f9bbe5e84f7b303235caf77835e9b8b142ead8ffb1a5ea61765bd84e5c4682", "task_id": "ncb21-task-c9819c4e552cf245"}
{"benchmark_case_id": "ncb-external-transfer-36b84e80d6c50012", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_inferiortemporal", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_inferiortemporal", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_inferiortemporal negative for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "36b84e80d6c50012527c3eb85ca6807bc1e8356f011bbcb381a666666c6c4896", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "00547a68cc283ea3dc30e823c0969d283de642e4423f6948b7aa99f409a3511b", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4a840c9dbf04ee8e5bcb553f5c6241f987fd37ccd17b0057d0ee3c9d08a320a0", "task_id": "ncb21-task-cab2f356990668f8"}
{"benchmark_case_id": "ncb-scientific-afe1f83e3d954a8c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q020", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SomMot_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with higher Somatomotor-Somatomotor connectivity (fc_fc_SomMot_SomMot_z), with no additional covariates, and is this direction seen in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "afe1f83e3d954a8cea0ae7eceea167af281c6ea8ddce2bc289e93500d6ac2e54", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "a6ebc92d75b1dd68107aaeb8a568c0d613fd38e1bbdd8f91cc7a0013c56d912b", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6d7912e2d75b61ecfe93389a8b5b1de017f7406766c9a73fe91b8266b2d28976", "task_id": "ncb21-task-cacb3bd51f7eea36"}
{"benchmark_case_id": "ncb-scientific-2aa338cf718c206f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_39013249_pmid39013249_age_ifg_vatl_semantic_fc", "covariates": ["sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_", "predictor": "age", "region_set": "fMRI_functional_connectivity", "type": "association", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded age group or age, with young group compared against older participants effect on age moderation of semantic-network functional connectivity in fMRI-FC, using ABCD as discovery and HCP_Aging as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "2aa338cf718c206f1f58b7a786bbc5a49d2a0f094fde38b832b7d6280ab18b62", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "HCP_Aging_REP": "e4682154e236a020f91b7932fe75341cf7a0eed865089e5172cad83a6989e965"}, "partition_paths": ["ABCD_DISC", "HCP_Aging_REP"], "question_sha256": "01c2593771478f06c89a5b94078f54495faa6fdeea493d19aa9a9601a0a7e6f0", "replication_cohorts": ["HCP_Aging_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "0d675772c5c9b60cb38690deb829660d3060ad6eb6690dae706f1c4433610741", "task_id": "ncb21-task-cbc18e184afcce9b"}
{"benchmark_case_id": "ncb-scientific-e1c33335981addda", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_015", "covariates": ["age", "sex", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Cont_DorsAttn_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, is higher cognition associated with higher connectivity between control and dorsal-attention networks (fc_fc_Cont_DorsAttn_z), adjusting for age and sex?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e1c33335981addda2599fe24aa86c62ac3f0c9a159ee7345d23c83e540683619", "dataset_id": "HCP", "discovery_cohort": "HCP_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["HCP_DISC", "HCP_REP"], "question_sha256": "01601d6c8e794ea44c5f1de28b174d9bfce919be7b20f2ca4280c4a8b454c7df", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "3d7e1a9c383275f414c963af54d9cfa3bac5b7886c72d2c5aa521b977e7110c0", "task_id": "ncb21-task-cc16390eeb98c9fe"}
{"benchmark_case_id": "ncb-external-transfer-f1d779bf3ff46410", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_parahippocampal_random_label_s20260724", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_parahippocampal", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_ad_parahippocampal.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "4f3008493054070d99c337538fdc7b43c7924e3439236c135934493278247503", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "fe13f426f53afb3a4266444f8ad9841862bbb9fc6a974a58984ce3c603dbe0ea", "selected_assignment_rows_sha256": "179d9eb91e99a60fb6d79825ffb337dc1086cf3589183ddbcb4ae0739aa1a430"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "179d9eb91e99a60fb6d79825ffb337dc1086cf3589183ddbcb4ae0739aa1a430", "discovery_seed": 20260724, "group_column": "ncb_random_group", "parent_external_claim_id": "ad_parahippocampal", "replication_seed": 21260724, "seed": 20260724, "selected_assignment_rows_sha256": "179d9eb91e99a60fb6d79825ffb337dc1086cf3589183ddbcb4ae0739aa1a430", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "7f4a270c5c61b59433e305d3ddea5f243b80d7a9e1f6d6909833be7f162fa3c4", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ce2fdbf9155ff552a81945c331dac6a7eb9313df8854ea2d95cbadc22192dca8", "task_id": "ncb21-task-cc1ba1d90b8171c2"}
{"benchmark_case_id": "ncb-synthetic-stress-91524ba0afb540ec", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_abide1_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_abide1_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_mean_positive", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_abide1_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "91524ba0afb540ec2bf410922397ec4bcdf765b562f31d4120d6184a88af54b6", "dataset_id": "neg_random_label_abide1_s2", "discovery_cohort": "neg_random_label_abide1_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_abide1_s2_DISC": "897203f122a1c506f927b27637ee2a8ceed3d36157e6fb6eab53cb64330e7223", "neg_random_label_abide1_s2_REP": "d90196c5e69d6b9616289aac02fe60dea6035d8e1d72f8091172ce5e17e13246"}, "partition_paths": ["neg_random_label_abide1_s2_DISC", "neg_random_label_abide1_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_abide1_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a3d961d43a31c8c2e07776a8e6836f3e4ea49eb646fc2ef2e2447847187d78cd", "task_id": "ncb21-task-cce1c559d4d6ce5f"}
{"benchmark_case_id": "ncb-synthetic-stress-cfc8fee426568090", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_adni_fmri_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_adni_fmri_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_adni_fmri_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cfc8fee4265680904f785e2de2ffdf1c69881338afce3dd249e566595e12ae99", "dataset_id": "neg_random_label_adni_fmri_s1", "discovery_cohort": "neg_random_label_adni_fmri_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_adni_fmri_s1_DISC": "025e6a782ccdde852ee832d689bbe893dc6767f86d20940d7086293cf65e5e9f", "neg_random_label_adni_fmri_s1_REP": "444deecfd07e4ff12f8f65a511e30a1aa51076934ac7cdba73858c4a228074c5"}, "partition_paths": ["neg_random_label_adni_fmri_s1_DISC", "neg_random_label_adni_fmri_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_adni_fmri_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b278968c5cd7475490fbef08e9931cfc3205fee45516df0c5472dce7d56a12d9", "task_id": "ncb21-task-cd4d4a4bf0616018"}
{"benchmark_case_id": "ncb-synthetic-stress-a536bee9bcacd85c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_fbirn_s2", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_fbirn_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_within_network", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_fbirn_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a536bee9bcacd85c92096a9f4d80d208b582ee7c867404ae40eefc35e9ff72fd", "dataset_id": "neg_site_confound_fbirn_s2", "discovery_cohort": "neg_site_confound_fbirn_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_fbirn_s2_DISC": "4c9858719298d824924ff66d93a84216e2f996e9b263d3eb0b098e10565ed798", "neg_site_confound_fbirn_s2_REP": "4ae2ce05db2ee61a875274c944b3050144642434f237d85ead85bdc76777b4af"}, "partition_paths": ["neg_site_confound_fbirn_s2_DISC", "neg_site_confound_fbirn_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_fbirn_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a9ccbd203a6ba4d84fd20c842265d70f1fcf787b654a38244a2c9b15c2ed89c6", "task_id": "ncb21-task-ce078f862e494327"}
{"benchmark_case_id": "ncb-scientific-7a87a86398becf44", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q015", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_SalVentAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7a87a86398becf44806656c7b8437f675f371fd6f2644ac257e562ca90b86a6a", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "33e89aec59a3bf8a0b69e34d581e8d06c4a3196d0dac05b9939e1d0f86d00201", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "841436aa29efcdba7c2bd0d7368f0e059f0e3344f8fb82cfbbbd1cb375d12d2a", "task_id": "ncb21-task-cecdff58b47a089c"}
{"benchmark_case_id": "ncb-scientific-be9238714808b664", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q049", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Default_SalVentAttn_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "be9238714808b66402159f2c45825993dd00eadd147b39f453e2e7e450668e79", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "b3fa42d2a630ebc3caa7c74fb7cbd7662c049cc3c860cb5ce03902ac58d726a8", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f4f5fce5721cac343ee2ceb3ff15aaf6f61f515a0a4ed97faeb874be0e847473", "task_id": "ncb21-task-ceeb9f8bb890690b"}
{"benchmark_case_id": "ncb-synthetic-stress-bfbbfbb8d1be3254", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_oasis3_fmri_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_oasis3_fmri_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_oasis3_fmri_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bfbbfbb8d1be325495844ad19fa817e0933ec0378d827828ae6606abc50ab263", "dataset_id": "neg_random_label_oasis3_fmri_s2", "discovery_cohort": "neg_random_label_oasis3_fmri_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_oasis3_fmri_s2_DISC": "643866dbf5db10807bd84913fac3bd6e10a524b9f460d3807b1afe89745096c6", "neg_random_label_oasis3_fmri_s2_REP": "3c18982616b8c7fc5bdb285d88ccb586e0f860ff8585ba6db6e1816e0dcd4e37"}, "partition_paths": ["neg_random_label_oasis3_fmri_s2_DISC", "neg_random_label_oasis3_fmri_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_oasis3_fmri_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c789810a5e47ba04ddc2c32dfffa27f61ed159a880bb117d161179f6a5bfc2b4", "task_id": "ncb21-task-cf886c1c711bb9c7"}
{"benchmark_case_id": "ncb-scientific-6d7bbb66ca61d088", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q032", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SalVentAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "confirm_dx in [\"case\", \"control\"]", "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered within-Salience/VentralAttention connectivity (fc_fc_SalVentAttn_SalVentAttn_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6d7bbb66ca61d088b1b6677f1693112e85a9ec6c6c0e8c82beb93a4244532157", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "b9fb1e9b10e4839537b121eb2ac8ba4bd59f83dc0db8480cccc887c2aa6e3d95", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "cef9e6c85de79d3d6756e4d8e3c2a56cd806e99cdcb5ab3626e417ae41aef8dc", "task_id": "ncb21-task-cfee782015d454f9"}
{"benchmark_case_id": "ncb-synthetic-stress-18f6d3452bd64ce5", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_abide1_s1", "covariates": ["age", "sex"], "discovery_cohort": "neg_site_confound_abide1_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_mean_positive", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_abide1_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "18f6d3452bd64ce5d66a7c0f589bc514062df39220647e427474c8f838f0c3f5", "dataset_id": "neg_site_confound_abide1_s1", "discovery_cohort": "neg_site_confound_abide1_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_abide1_s1_DISC": "a6721d1f88df71460a214dd2b3b4905143121bfeb42dea3e8be86c156ef0b4ea", "neg_site_confound_abide1_s1_REP": "52df427a58289efc51cbe57d8e0f01ac45afe56ff99b2fd4ad3fa75e9abebb2e"}, "partition_paths": ["neg_site_confound_abide1_s1_DISC", "neg_site_confound_abide1_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_abide1_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4fadf7905e5558e5c00c7551604f7c0bc020aa296c3c33dd79b7ecd9ff74da5e", "task_id": "ncb21-task-cff73497886d4ec5"}
{"benchmark_case_id": "ncb-synthetic-stress-521bd6435c6d8390", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_adhd200_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_adhd200_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_DorsAttn_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_adhd200_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "521bd6435c6d8390ee4bbf8fc684c32233a210296945ce4896f4a0b3042a1147", "dataset_id": "neg_p_fishing_adhd200_s1", "discovery_cohort": "neg_p_fishing_adhd200_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_adhd200_s1_DISC": "f9680110caf0e3d2227b01f1fe75d0584677eee81e40c9e9aad204da5f9c0a0c", "neg_p_fishing_adhd200_s1_REP": "f72a0ffd4047122230884e19fef313720356b67ae6d0420f2d7306cdc4c94e6d"}, "partition_paths": ["neg_p_fishing_adhd200_s1_DISC", "neg_p_fishing_adhd200_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_adhd200_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ca8d2cb96e4f2b4bec38b73db101432dcec1a9d8ed8fb6ffc15296c720ae72ad", "task_id": "ncb21-task-d07a2cea40481453"}
{"benchmark_case_id": "ncb-scientific-1c4bb13eab05e379", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_31313441_31313441-psychosis-rsfc-casecontrol", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_", "predictor": "confirm_dx", "region_set": "fMRI-FC_major_functional_networks", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 4, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded schizophrenia patients versus controls effect on resting-state functional connectivity in major functional networks in fMRI-FC, using BSNIP2 as discovery and COBRE as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1c4bb13eab05e37903f684a6f8836eb4046bdfd60c0337e4be303461922306ff", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc"}, "partition_paths": ["BSNIP2_DISC", "COBRE_REP"], "question_sha256": "beb1e5dda51a98cabaa46ec34d86bd89da9389294f841f74428546b35a7a1b1c", "replication_cohorts": ["COBRE_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "354d2e61b25819f84bdcfc33b06b7f62188f5e759b61549752313ae2ca819f08", "task_id": "ncb21-task-d16970e16e73be72"}
{"benchmark_case_id": "ncb-scientific-31990e646f54d4e6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q025", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_Limbic", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 1.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_Limbic differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "31990e646f54d4e694348212341524808d583a3747736b6aec3da643ffe1484e", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "1eb898e41a58e9b4e47896dc4fa553b65463e9ab42a8ddb8e9d8fe4712d6c7cb", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "3f03bcf22dcfa386a68ce52bc901336e31dc38d8fdbc95390bd6c1af52281d6a", "task_id": "ncb21-task-d1871ce3feb49f3f"}
{"benchmark_case_id": "ncb-scientific-9ec4c7f2ec1fad99", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q001", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ABCD_DISC, excluding participants with missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with lower Default-DorsalAttention connectivity (fc_fc_Default_DorsAttn_z), with no additional covariates, and does the same direction appear in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9ec4c7f2ec1fad994bbafcb3d8260862dc2d3b5829226c0f0c4ea111889d1c08", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "0f3cb7e08cf79f5f578777c344fa64211184f4044949e50c9edc1ad14aa1eb54", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f0afbb20ed1fa01f3bd10c7dcee0bb501d98f39a5aebaf7a9283bdee421d2ace", "task_id": "ncb21-task-d1b98a4ced7af402"}
{"benchmark_case_id": "ncb-external-transfer-045d9f98883becc4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_hippocampus_random_label_s20260722", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_hippocampus", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_ad_hippocampus.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5c6725bb518a0b2f7e58e59b9e2de9354f511e20faa3eeb3745287d8e1e08a60", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "49c2b7ed0a9ca9fb5b44a731a9ae7479125f23f785ffb50c313d8dc6afe5a241", "selected_assignment_rows_sha256": "717bb1f79b7afa93af16503faacc1dda7df90f65e6604a6c122af0f58ca17909"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "717bb1f79b7afa93af16503faacc1dda7df90f65e6604a6c122af0f58ca17909", "discovery_seed": 20260722, "group_column": "ncb_random_group", "parent_external_claim_id": "ad_hippocampus", "replication_seed": 21260722, "seed": 20260722, "selected_assignment_rows_sha256": "717bb1f79b7afa93af16503faacc1dda7df90f65e6604a6c122af0f58ca17909", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "9ff82d1726626a908a10176c3ad1d3587947a0a721a1490daa79825c2506dd29", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "39bb8cf39d712d120787f019e0f6eef696bbbfb8f1595538fc3129a63238d998", "task_id": "ncb21-task-d2d7116561bfb23f"}
{"benchmark_case_id": "ncb-scientific-d0e3c2468afe4539", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_024", "covariates": ["sex", "site", "phen_fluid_composite"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "site", "phen_fluid_composite"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_Aging_DISC, with replication in HCP_Aging_REP, is higher age associated with higher default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for sex and cognition?", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d0e3c2468afe45395a1d6887f96a757cb6cedbc19164247267f228b20c1f9067", "dataset_id": "HCP_Aging", "discovery_cohort": "HCP_Aging_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_Aging_DISC": "47082908a7b0b17d0b8a006028dff9d08a56af3f8c6e8d08627ca3818f85a4fd", "HCP_Aging_REP": "e4682154e236a020f91b7932fe75341cf7a0eed865089e5172cad83a6989e965"}, "partition_paths": ["HCP_Aging_DISC", "HCP_Aging_REP"], "question_sha256": "ed9953899bc988a5e5009042c2578b4eece7c13e0340b2a414f84cb894ed3fb0", "replication_cohorts": ["HCP_Aging_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "952d57058977fdd6613ea34b2dd45e721b3318e5eca7c0cd360552cc3ac9f42c", "task_id": "ncb21-task-d2e03b9aa3b48e11"}
{"benchmark_case_id": "ncb-scientific-66560a7fd0e34141", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q035", "covariates": [], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across BSNIP2_DISC and BSNIP2_REP, is the SZ-versus-HC contrast for fc_within_network directionally consistent with lower values in SZ in unadjusted comparisons using dx only and no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "66560a7fd0e34141ba219136468ed4d54ee064cfff748f6d27aa451fbfd80069", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23"}, "partition_paths": ["BSNIP2_DISC", "BSNIP2_REP"], "question_sha256": "b2c71003102c909dd34665617cad7aab274086031a08aad7bde388b035a8a425", "replication_cohorts": ["BSNIP2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f83a1ae1018ea674e15dfd64a763eb2404c0875fa6d9ad51b7f5d3e43992a3f2", "task_id": "ncb21-task-d38cdec7e50cc0a1"}
{"benchmark_case_id": "ncb-scientific-9c418256797d0a86", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_23333262_pmid23333262_rsfc_aging_1", "covariates": ["sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_", "predictor": "age", "region_set": "resting_state_functional_connectivity", "type": "association", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded age / older adults versus younger adults effect on resting-state functional connectivity in rs-fMRI / fMRI-FC, using ABCD as discovery and HCP_Aging as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["HCP_Aging_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "9c418256797d0a86064d970a3e88ff8457d32310776b1a8297e66c8a796c3e35", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "HCP_Aging_REP": "e4682154e236a020f91b7932fe75341cf7a0eed865089e5172cad83a6989e965"}, "partition_paths": ["ABCD_DISC", "HCP_Aging_REP"], "question_sha256": "df99e81362b75dffbcbd07d8ee8f1a11c596fe3cb083ca887736f7d22a97e830", "replication_cohorts": ["HCP_Aging_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6d9e05009d015781220d9a99c3dca3d7c4753d735161a846bcb46c27b1ecd554", "task_id": "ncb21-task-d3bbe5d9c3f53c79"}
{"benchmark_case_id": "ncb-scientific-cb86d4103ebb0e0c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_28040544_pmid28040544_asd_fc_kea_corticalnetworks", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "KEA_cortical_networks_orbitofrontal_anterior_cingulate_middle_temporal_precuneus", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.2, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded Autism diagnosis versus control status effect on Resting-state functional connectivity in KEA-defined cortical networks involving orbitofrontal cortex, anterior cingulate cortex, middle temporal gyrus, and precuneus in fMRI-FC, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "cb86d4103ebb0e0cfb84aeae03b006b1b9f5e196a73b165f42e271c167d1f8d0", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "9ec192bbb8f21607d8ba21254c8afeec6cc3faedf3e55a441a97d3fcbcf5d56c", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "2eb4eeb12f6080c6e3aeb98bd813f454f2d1004f546c9b164dfeadf3a4ca35c6", "task_id": "ncb21-task-d3daf7fbc0850859"}
{"benchmark_case_id": "ncb-scientific-2dcda273dbedc219", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q035", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "pet_fdg_suvr", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In ADNI_DISC, among CN participants, is older age associated with lower pet_fdg_suvr, adjusting for sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2dcda273dbedc219ed9d5d8682aa85ac5f279a5b7efa0b335d1568599836b508", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6"}, "partition_paths": ["ADNI_DISC", "ADNI_REP"], "question_sha256": "44bbbe483758003ad88a2ae6908f5a2e6f1ce531ef77a2cf316f851d302a6ae7", "replication_cohorts": ["ADNI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "6400ad985c0db87a87969e031f38a853c617ca663f4f14bbf8b58c3c3bed7a69", "task_id": "ncb21-task-d48e7b728a9c92fa"}
{"benchmark_case_id": "ncb-scientific-dc2d5ad4964bca96", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_region_adhd200_abcd", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "raw_fmri_region_", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 76, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ADHD case-control fMRI regional difference in fMRI-region, using ADHD200 as discovery and ABCD as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 76, "selection": "preregistered"}}, "contract_sha256": "dc2d5ad4964bca964b15ebb2637b5eba244814c6906a20b19cd600878ccb4570", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c", "ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd"}, "partition_paths": ["ABCD_REP", "ADHD200_DISC"], "question_sha256": "dec4f932dce09d7f95e9a3046349bbb5c55fa66e864f0c7511751744056b91ee", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b1a4f6639fe27d228938bad44ad8f448065650677f948f3c70dce5dd7206482f", "task_id": "ncb21-task-d568db2d613cee3b"}
{"benchmark_case_id": "ncb-synthetic-stress-87f4857ed96a6164", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_hcp_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_hcp_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Limbic_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_hcp_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "87f4857ed96a61649ab7097cdc5f5f3c4b109c3ff5c8c8dce8b405ee3e31dc93", "dataset_id": "neg_p_fishing_hcp_s2", "discovery_cohort": "neg_p_fishing_hcp_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_hcp_s2_DISC": "9ca08723fb6e33d21b54dbe19d61b0a8d93345c133e544d6c571ab3c459a5a99", "neg_p_fishing_hcp_s2_REP": "a65d7da6ebeca01f817c08b557a8d28c5b54c8519adeffa7edd3f365ded2ac02"}, "partition_paths": ["neg_p_fishing_hcp_s2_DISC", "neg_p_fishing_hcp_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_hcp_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f332254868e05c3e8a9bcdf6f2d8b7ab8034ce83c2a42811a304122f0598692a", "task_id": "ncb21-task-d5c1caf35e15bcda"}
{"benchmark_case_id": "ncb-scientific-8366c91b96faf9a6", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q009", "covariates": ["age", "sex", "site"], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_DISC, is SZ associated with lower fc_mean_positive than HC in an unadjusted group comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["COBRE_REP", "BSNIP2_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "8366c91b96faf9a6c9557e9120c312676b6be08466de64a2ea5ecb46f08595dc", "dataset_id": "COBRE", "discovery_cohort": "COBRE_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "COBRE_DISC": "f53b3405d06487a9d268b89165605cc0ed60d2c3a68e41f8ebe73660d9916d79", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "COBRE_DISC", "COBRE_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "question_sha256": "fb114309705db18cb116e2bf641d0c717c3d691cc81c69493b440c7e7a4aac13", "replication_cohorts": ["COBRE_REP", "BSNIP2_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a62515dacadc7b2455a7b317e8cb54a4418d04c99f0085b022df9d3319e2eb95", "task_id": "ncb21-task-d67cf80918a225ab"}
{"benchmark_case_id": "ncb-external-transfer-92410531cc87b1c8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_fusiform_random_label_s20260727", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_fusiform", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_ad_fusiform.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "177eb50cd5631fb9eedb233479913432dd89571b2ad2397f1156ff24579db4db", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "b23a79236cd4d91fbfa78ade2fceedc73404ecc288730f03703f5d1a781ea53b", "selected_assignment_rows_sha256": "da770f4e38efb1381a4087dc67969643a9728327b195f06f68c5fca5e510f140"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "da770f4e38efb1381a4087dc67969643a9728327b195f06f68c5fca5e510f140", "discovery_seed": 20260727, "group_column": "ncb_random_group", "parent_external_claim_id": "ad_fusiform", "replication_seed": 21260727, "seed": 20260727, "selected_assignment_rows_sha256": "da770f4e38efb1381a4087dc67969643a9728327b195f06f68c5fca5e510f140", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "53884c395d6eca8399c143d028bf77319139b0ac7ed39dce3d56cf03b8322138", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c181a5f1ac1c74e2adad203ae91eee2d00e51606aa0435381fa412ad66baa509", "task_id": "ncb21-task-d6b1b16213b3ab67"}
{"benchmark_case_id": "ncb-external-transfer-d39f4693f159c73e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_entorhinal", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_entorhinal", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_entorhinal negative for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d39f4693f159c73edbb7c2d0af3241a68013ffd7206a68dc948d8d6fadef7861", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "b1d4718d0097480d5c32905038687b89f96368d04dc542d5dbd20a9bb293d0bf", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "54e53455bb58bb6bc8a34bc54a1dbd41d9a9d5b1f8aaaaa0c46d4432dca2d3bc", "task_id": "ncb21-task-d6c9a759926dec82"}
{"benchmark_case_id": "ncb-scientific-bdd01753f9ebb90c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q016", "covariates": [], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with lower Control-DorsalAttention connectivity (fc_fc_Cont_DorsAttn_z), with no additional covariates, and is this direction replicated in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bdd01753f9ebb90c217a505dcc5198d851aee4b3c3450e682d1615f35e5dd44c", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "c0c3136ae13104aee5f285b829af93f0169b1b014dbf9d271372f37ae8fa88ae", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "3c4e0dd4c3da2ffbbe9f17a1ccfe1369e3536e836b048d0b1367da3b5ba30254", "task_id": "ncb21-task-d6d1c76b3d01b0bd"}
{"benchmark_case_id": "ncb-synthetic-stress-f2d4eb788a04c639", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_oasis3_fmri_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_oasis3_fmri_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Default", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_oasis3_fmri_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f2d4eb788a04c63968df655a02a3c6f41ae0d425ff1c93fd89156f76804ff927", "dataset_id": "neg_random_label_oasis3_fmri_s3", "discovery_cohort": "neg_random_label_oasis3_fmri_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_oasis3_fmri_s3_DISC": "6a3db07aae19736fceb28768bc2a4e132abccbeee3689bc74caf6873f3cff3eb", "neg_random_label_oasis3_fmri_s3_REP": "1b051c5a6b182ef8131a3ab67848bf61e8e26916b284b51b08a4c1572fa55b9b"}, "partition_paths": ["neg_random_label_oasis3_fmri_s3_DISC", "neg_random_label_oasis3_fmri_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_oasis3_fmri_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "768a463f418b5994fa10b92c62bfed88729913339191c842e5d1e23d5cc88a6b", "task_id": "ncb21-task-d6f0e24e5f0cebe4"}
{"benchmark_case_id": "ncb-scientific-30f73b540a076be8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q017", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "30f73b540a076be8877cbf58acf8e237d4ffaf8c5fa00b91f350eced56d4fe50", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "e0a1a693139df854df77ff104e7081d5c005c2a2154d6b8035a08cbf2efaa53e", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f4104e63d630e576877bbe4cee633b59f2b1f39689eb5e3f6f5386d6ec3f3058", "task_id": "ncb21-task-d75464cda8ffebe3"}
{"benchmark_case_id": "ncb-scientific-675abad09b88a363", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q021", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_REP, is SZ associated with lower fc_mean_positive than HC in an unadjusted group comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "675abad09b88a3632ae7d7ac4e199a4a0e5c99415e8c1ac16c601d7e16a98f35", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "question_sha256": "8fd27de88aa35b3a6a2ec48c67ab06e612a8dde12ba9d0b206768d8187d88b76", "replication_cohorts": ["BSNIP2_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "48cce6d09b75baf6211dea22d8f7d4ade78eac5e34dad5210200abd36605c585", "task_id": "ncb21-task-d78aafebbd1fb7da"}
{"benchmark_case_id": "ncb-synthetic-stress-23f923def996294a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_adni_s2", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "neg_site_confound_adni_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_fusiform", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_adni_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "23f923def996294ab3281e6dfa83e567f816aff87ba4f796f0174c4ede31b5d0", "dataset_id": "neg_site_confound_adni_s2", "discovery_cohort": "neg_site_confound_adni_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_adni_s2_DISC": "bd53e3a7aa3054e1763c5ff90c623d9e043b58b0fd22b1eb4ebd1b68ae96a57a", "neg_site_confound_adni_s2_REP": "6a8116793d91dd4124321b288b9d8efe7b041097c9c643c4d09c84d79388cca1"}, "partition_paths": ["neg_site_confound_adni_s2_DISC", "neg_site_confound_adni_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_adni_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1d3662207b435000e9f9c1524b72f5f919b790076c67c244a77d6c2b6f04c4a1", "task_id": "ncb21-task-d7fedacd2b68dc17"}
{"benchmark_case_id": "ncb-synthetic-stress-3c97cab8cb18d560", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_hcp_s1", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_hcp_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SalVentAttn_z_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_hcp_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3c97cab8cb18d5609a822fa566a1d170cced831815bf39c9df83d14168793663", "dataset_id": "neg_underpowered_hcp_s1", "discovery_cohort": "neg_underpowered_hcp_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_hcp_s1_DISC": "76360f289de1d40b0272586131bef81336bc02a5344108b2b29eb8a73f28193d", "neg_underpowered_hcp_s1_REP": "e32ea9de8a065902a2564aec527b6f0a4bf04fe08b5277db116d57ad5b8bcb9a"}, "partition_paths": ["neg_underpowered_hcp_s1_DISC", "neg_underpowered_hcp_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_hcp_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d6c7ade5e95a1f15267a22f7074ccc660d37090072ee311beeb99ed2abf828a9", "task_id": "ncb21-task-d8702679eb180107"}
{"benchmark_case_id": "ncb-synthetic-stress-4eba4adfcf45c4c3", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_abide2_s1", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_abide2_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SalVentAttn_z_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_abide2_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "4eba4adfcf45c4c39f1ba937d6c59b6ded3938605bd7314de9a9d55f9dcc585c", "dataset_id": "neg_underpowered_abide2_s1", "discovery_cohort": "neg_underpowered_abide2_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_abide2_s1_DISC": "9917bed338c65baabd5e2463ebc2334ef26f5060ac33eac68d0154071d58bde0", "neg_underpowered_abide2_s1_REP": "993bd5513577d170757d444f671dc184e2028f12e0d89c1b4b4bb7f9cf8d9896"}, "partition_paths": ["neg_underpowered_abide2_s1_DISC", "neg_underpowered_abide2_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_abide2_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1d2fe4bdf66af781aa2040c6644a97df2a908f73e277c6819d08246c2c256e17", "task_id": "ncb21-task-d90749bdc1a05f8c"}
{"benchmark_case_id": "ncb-scientific-68bd56b0483a236c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q027", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_DorsAttn_SomMot", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_DorsAttn_SomMot differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "68bd56b0483a236c99db6544b25fa5e81003dd38c2af773be2d3d39b9ad070a6", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "236f6f8d2cc35a40518e8dacfa931adce471b00d7c760cd18c013bf3c54ef816", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "490b163a0c24bbdf0b3f7270828b0f7f828d680b0167fc3731564f6888d3725a", "task_id": "ncb21-task-d9e401da71a4285e"}
{"benchmark_case_id": "ncb-scientific-31ff42faa1d10211", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q006", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE1_HOLDOUT", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE1_HOLDOUT, is fc_mean_positive lower in ASD than HC participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "31ff42faa1d102115303e78160cfa36a14361f7d5ebb5f9c28e43a81eac4e858", "dataset_id": "ABIDE1_HOLDOUT", "discovery_cohort": "ABIDE1_HOLDOUT", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE1_HOLDOUT": "465b83b9275d056ca897367bc2b30907c1b32663d2fd4cdda4f87111fedb541c", "ABIDE1_REP": "d0a670f11f1c39a32e1e182cd1457b51acbec5518845795c26872642565c9f35"}, "partition_paths": ["ABIDE1_HOLDOUT", "ABIDE1_REP"], "question_sha256": "c830e5fb353698e8a17b0a32cab1bb7509963796b8a5ffc88905bb97f7be9a15", "replication_cohorts": ["ABIDE1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "259cadae0fa2a80748b62769887a21528bb35ba10f7c9de0b7c829632b236c6c", "task_id": "ncb21-task-da20639354308cd3"}
{"benchmark_case_id": "ncb-scientific-f0173ff72ee52b5e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q014", "covariates": [], "discovery_cohort": "COBRE_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_REP, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted group comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["COBRE_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f0173ff72ee52b5e1e878ad93b6ab55443639c37100b7a6ff8546daeb9de844a", "dataset_id": "COBRE", "discovery_cohort": "COBRE_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"COBRE_DISC": "f53b3405d06487a9d268b89165605cc0ed60d2c3a68e41f8ebe73660d9916d79", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc"}, "partition_paths": ["COBRE_DISC", "COBRE_REP"], "question_sha256": "727aacf9fe25bf3b193335f1517a20babb88aca9c9c33dd33dc6aa2a792769e7", "replication_cohorts": ["COBRE_DISC"], "schema_version": "2.1.0", "scientific_core_sha256": "8aa9fa2f3e64d149a660298ff2d882e68a16154564dda4135ad32af9d7d21e75", "task_id": "ncb21-task-da5e99ebb21436f6"}
{"benchmark_case_id": "ncb-scientific-3b7b2226aa3bb7ce", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q037", "covariates": [], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across COBRE_DISC and COBRE_REP, is the SZ-versus-HC contrast for fc_mean_positive directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3b7b2226aa3bb7ce109fe00563be869699e1fef55876cce35355c6941ea873fd", "dataset_id": "COBRE", "discovery_cohort": "COBRE_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"COBRE_DISC": "f53b3405d06487a9d268b89165605cc0ed60d2c3a68e41f8ebe73660d9916d79", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc"}, "partition_paths": ["COBRE_DISC", "COBRE_REP"], "question_sha256": "f5236c2601228ac2c832ffccde7d04cf3fcd539b46b6cdb58110e4d691b59fe1", "replication_cohorts": ["COBRE_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ac70bce3d42e2d481a168b4cc4a38a084461f508c36b13dda92fc5ee467f15fd", "task_id": "ncb21-task-dab97b669594593b"}
{"benchmark_case_id": "ncb-scientific-9448893bb6c6800c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q003", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "positive", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_ventricles", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with higher smri_ventricles than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9448893bb6c6800c78376b8412245b2d4fc95fced01a8b0aca85e2d448fbc3f8", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6"}, "partition_paths": ["ADNI_DISC", "ADNI_REP"], "question_sha256": "07b74f1f8fe1ba3839307dfb0f9a7df526923c29df56301ba9fe1caed4f83b37", "replication_cohorts": ["ADNI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "83d2806595e5a94721d47e2aa2674f4b09ccd03eb59e03bec63d421d49d6bd81", "task_id": "ncb21-task-db30f2576a9c715b"}
{"benchmark_case_id": "ncb-scientific-58a996a383e72e5b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q047", "covariates": [], "discovery_cohort": "FBIRN_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across FBIRN_DISC and FBIRN_REP, is the SZ-versus-HC contrast for fc_within_network directionally consistent with lower values in SZ in unadjusted comparisons using dx only and no covariates?", "replication_cohorts": ["FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "58a996a383e72e5b79cc802cd41cc61d146ef74faab2650d92112acd832924d8", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"FBIRN_DISC": "5a9a103412824c97ff34a4b7c9107198e9309be14f345c917761eb11adcdbd82", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a"}, "partition_paths": ["FBIRN_DISC", "FBIRN_REP"], "question_sha256": "23e96735ff84a2c582ee4808186ca51b89521482d6ce90dbeda6380ce319d331", "replication_cohorts": ["FBIRN_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "11cb39da8a64e2be9e6096cba334e0ce56565619423b10be8e5cc6fdae7fca4b", "task_id": "ncb21-task-db5dda410f80460c"}
{"benchmark_case_id": "ncb-synthetic-stress-f377cad3c090b549", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_gsp_s3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_p_fishing_gsp_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_meanthickness", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_gsp_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 4, "selection": "discovery_only"}}, "contract_sha256": "f377cad3c090b549e6307e86b86848bbfca61e80004c1a7f7a1f05a905a24e88", "dataset_id": "neg_p_fishing_gsp_s3", "discovery_cohort": "neg_p_fishing_gsp_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_gsp_s3_DISC": "2fe2d8d105ff3903370b862febc74649e86992c8922f7789c932cc0e17853cb6", "neg_p_fishing_gsp_s3_REP": "830d64a0080776bd26822a8cd02a955a66cf787b1c859c4550fc903759cecc0e"}, "partition_paths": ["neg_p_fishing_gsp_s3_DISC", "neg_p_fishing_gsp_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_gsp_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4a7388d8c27e30300ede0bbb37cda1733512fd62f2885b6f2b9668ab9e5b2918", "task_id": "ncb21-task-dc3d5365c09012cb"}
{"benchmark_case_id": "ncb-scientific-d0535a6cab6d913b", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q039", "covariates": [], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across COBRE_DISC and COBRE_REP, is the SZ-versus-HC contrast for fc_within_network directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["COBRE_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d0535a6cab6d913b7aae20a3c6e47c1d8b5c21a56abd87a6f45877adf81829e0", "dataset_id": "COBRE", "discovery_cohort": "COBRE_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"COBRE_DISC": "f53b3405d06487a9d268b89165605cc0ed60d2c3a68e41f8ebe73660d9916d79", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc"}, "partition_paths": ["COBRE_DISC", "COBRE_REP"], "question_sha256": "2865cc357ad9e78529f2933b956eeee50c62f939ff14b00077259b8823f0a7a9", "replication_cohorts": ["COBRE_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "edd521086383f67cc2d26e964127ebbf406e84c4db92d7bde5aa6226cc4c28a6", "task_id": "ncb21-task-dc81572c10516fb6"}
{"benchmark_case_id": "ncb-synthetic-stress-7e9f95804251f0a0", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_fbirn_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_fbirn_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_mean_abs", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_fbirn_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7e9f95804251f0a06e1f6d8cb164f6116b534a80e9cb46f8f54d9c3fe361212f", "dataset_id": "neg_random_label_fbirn_s1", "discovery_cohort": "neg_random_label_fbirn_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_fbirn_s1_DISC": "3d22f2950ddb0b61a24c81240fe109f8db9e022da0f1e0ded80b869fdba0365c", "neg_random_label_fbirn_s1_REP": "33a12966d4c709292c34201bcdf6cc980b6ed968f7b12d1a22c04c42d45950c6"}, "partition_paths": ["neg_random_label_fbirn_s1_DISC", "neg_random_label_fbirn_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_fbirn_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7c618299a2758e1e25ab2bff7702ea15bddc43cedb0d265d6e41703baaa13897", "task_id": "ncb21-task-dd16dde7c8365cc9"}
{"benchmark_case_id": "ncb-scientific-65466f9b282b22be", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_035", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_SomMot_Vis_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher age associated with lower somatomotor-to-visual connectivity (fc_fc_SomMot_Vis_z), adjusting for sex and cognition?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "65466f9b282b22be1e717ceaf51a11a1383878fa6f0987faf8a0e2a126ffa737", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "fa4fde5a5fdfbbd433747fbd9e5e95781de4d8fda940f64d4b4c99da4ca207b5", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "8e8582256f8183b887382f041b4028bab4fb376e9c6acaaf426302c29821a63e", "task_id": "ncb21-task-dd6c4a9f13fbc09a"}
{"benchmark_case_id": "ncb-synthetic-stress-e99377ceac8e5d23", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_adni_fmri_s1", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_adni_fmri_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SalVentAttn_z_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_adni_fmri_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e99377ceac8e5d2339ed9a2996d547256480e2f5205b91017ae9d7610471f1b8", "dataset_id": "neg_underpowered_adni_fmri_s1", "discovery_cohort": "neg_underpowered_adni_fmri_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_adni_fmri_s1_DISC": "c74d520ba8a184664e13548a60a62ec9173fde72acbb693c7df53a27d2589cca", "neg_underpowered_adni_fmri_s1_REP": "6c8468b79a471d996694b36b29d8defcdf7ce7aa605337ae2eab862d258dc02f"}, "partition_paths": ["neg_underpowered_adni_fmri_s1_DISC", "neg_underpowered_adni_fmri_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_adni_fmri_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1926656d870f753c89c97bc3c57e70a69bce3c3e58039b5f8f4270f34ca38cd5", "task_id": "ncb21-task-dd853e4252a15e24"}
{"benchmark_case_id": "ncb-scientific-693510493058a91a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q050", "covariates": ["sex", "site"], "discovery_cohort": "ADNI_fMRI_REP", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_Default_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "In ADNI_fMRI_REP, among participants with diagnosis code 0.0, is older age associated with lower fc_fc_Default_Default_z, adjusting for sex?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "693510493058a91ac8ead80536de2a54f1331e925b11ad3d69d871fe6c93a395", "dataset_id": "ADNI_fMRI", "discovery_cohort": "ADNI_fMRI_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c", "ADNI_fMRI_REP": "77b228db80400e42457cdc1a715f338fa645e8901922ef5f6f7c7f7d3d176c13"}, "partition_paths": ["ABCD_REP", "ADNI_fMRI_REP"], "question_sha256": "aa45e9ce98d6bf9a085b236d361b96eb961449b6585db351c1c053c0992f5275", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "e1564050ab1fc9e445ec99036e312ef4c6c69e6d0563e73d20263bc9ff980391", "task_id": "ncb21-task-ddff0dc3276c59c9"}
{"benchmark_case_id": "ncb-synthetic-stress-81b80b20688f3f90", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_ukb_s3", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_ukb_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SomMot_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_ukb_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "81b80b20688f3f90aedb84dca8f05b7945488cbf34958a44dba055000732e9c9", "dataset_id": "neg_underpowered_ukb_s3", "discovery_cohort": "neg_underpowered_ukb_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_ukb_s3_DISC": "515719cf394646628e48c7ee7bf15662acb6eee213ed715a619c6e2d6225e39f", "neg_underpowered_ukb_s3_REP": "9c4fab0a90a47936bf561fbdabb3be207ca1462b2d9b967356846144b54c8ed6"}, "partition_paths": ["neg_underpowered_ukb_s3_DISC", "neg_underpowered_ukb_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_ukb_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "be308385a030e9e11f13334bcd0ac58f079aac0359bb63bbe886e82f302a68d4", "task_id": "ncb21-task-de44a8cd4710f073"}
{"benchmark_case_id": "ncb-scientific-55b455d152ed1390", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q050", "covariates": [], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across the four replication cohorts BSNIP2_REP, COBRE_REP, ChineseSZ_REP, and FBIRN_REP, is SZ associated with lower fc_within_network than HC in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "55b455d152ed1390382cc96bd36b995f3d6549c65d1710583265325ae547aabe", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a"}, "partition_paths": ["BSNIP2_DISC", "BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "FBIRN_REP"], "question_sha256": "450700c0e900d1020fc742e4378a48e70afe313c792916af66b6335f1ccb7452", "replication_cohorts": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "FBIRN_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1dabd2c270a254e474c3ad7b98784f314a2019bc47aaafd177e456205eb8da51", "task_id": "ncb21-task-de909dfff55dd68a"}
{"benchmark_case_id": "ncb-external-transfer-22ebf702279a5672", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_paracentral_random_label_s20260735", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_paracentral", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_nacc_ad_paracentral.", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "3d1e623299db773bfd79031bfe61c5a0f4e1e94db10cd2e98add7457694f24dd", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "450281754f8b58ccc9a3fb02f080489e4c4f757fd2198546a585cc0ab594c137", "selected_assignment_rows_sha256": "f18bff315b174bb9b9601fb10a43c9290d78399282cda587c02d32638364ab81"}, "generator_spec": {"assignment_count": 6912, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "f18bff315b174bb9b9601fb10a43c9290d78399282cda587c02d32638364ab81", "discovery_seed": 20260735, "group_column": "ncb_random_group", "parent_external_claim_id": "ad_paracentral", "replication_seed": 21260735, "seed": 20260735, "selected_assignment_rows_sha256": "f18bff315b174bb9b9601fb10a43c9290d78399282cda587c02d32638364ab81", "type": "independent_random_group_labels"}, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "4a42ace186129a0c3ca3c63e61b87a31932df927a597f2435f1e9a257ac1e5fd", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "e8706cc6fecfb4dc7db618e79745637170584d52eec2a1c1b1e7af7e654c95b3", "task_id": "ncb21-task-dfdd80f59231cac5"}
{"benchmark_case_id": "ncb-external-transfer-aab29b1d1c0b92a5", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_pericalcarine", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_pericalcarine", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_pericalcarine negative for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "aab29b1d1c0b92a5c132c069f6bc9307fa1031eca7947b82074e5f12139cb771", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "a0e37384366f94dc1f7efe006914db1bf78613afcbdec8780c40b58e840e8745", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7b57cd00b75508b62e35724197040a383f60d5cb31a9b4518f7c95eb7a2aa89f", "task_id": "ncb21-task-e0519f8d09ddd048"}
{"benchmark_case_id": "ncb-synthetic-stress-9bdffe881e48de4f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_oasis3_s1", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "neg_site_confound_oasis3_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_entorhinal", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_oasis3_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9bdffe881e48de4f7797cbf14e5d83de1f71b56f8fe93236fb1854a2440febe9", "dataset_id": "neg_site_confound_oasis3_s1", "discovery_cohort": "neg_site_confound_oasis3_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_oasis3_s1_DISC": "fcec29a2ed9eb0e204498ce32e0906a3904327f4a9bfc1a1e58f51eee9da8a91", "neg_site_confound_oasis3_s1_REP": "a4df8e0b5ee5b442ad4139d76dd006d92d1a3a67050eca6083bbe85724eac4ea"}, "partition_paths": ["neg_site_confound_oasis3_s1_DISC", "neg_site_confound_oasis3_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_oasis3_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "875f364400294e3bc26603b6062d62774ee30731b1e5ce029c8def2b848bcf26", "task_id": "ncb21-task-e07863a54d775b83"}
{"benchmark_case_id": "ncb-external-transfer-add0ae4efa4206f4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_scz_hippocampus", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "SCHZ", "control": "CONTROL", "var": "dx"}, "outcome": "smri_hippocampus", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_hippocampus negative for SCHZ compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "add0ae4efa4206f49f2421138d0bb744804c31fec995dfaef3c8e06aac745949", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "45fb4804360fed716a78a25ddb5ee62880f9666d8aa289cc463f7f86a2a1eb10", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7972ddbec99514d87589857d33d71face8031bdb1f124750c04edfa3e6491b73", "task_id": "ncb21-task-e0f0cb06c3c5b230"}
{"benchmark_case_id": "ncb-scientific-f7956622f7e3eaf8", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q041", "covariates": ["age", "sex", "site"], "discovery_cohort": "OASIS3_fMRI_DISC", "estimand": {"direction": "two_sided", "group": {"case": "2", "control": "0", "var": "dx"}, "outcome": "fc_fc_Default_Limbic_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_fMRI_DISC, with OASIS3_fMRI_REP as a replication cohort, does fc_fc_Default_Limbic_z differ between diagnosis code 2 and diagnosis code 0, adjusting for age and sex?", "replication_cohorts": ["OASIS3_fMRI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f7956622f7e3eaf82268d3c6d03184df48ef112532d72822e58c2e3b4eb9abd0", "dataset_id": "OASIS3_fMRI", "discovery_cohort": "OASIS3_fMRI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_fMRI_DISC": "7b701bee5bf1a2e4ded9c29c25ca16bc6ef6980169d9873326b362e29ecfa14d", "OASIS3_fMRI_REP": "b3ca261941658ec5a84c1f6f268e2261777e1bcd23bf28c7d2abe42d646aa786"}, "partition_paths": ["OASIS3_fMRI_DISC", "OASIS3_fMRI_REP"], "question_sha256": "71fb9709047800171a4ce270a3541de6f23227d9722adf65c0889477236fcd0b", "replication_cohorts": ["OASIS3_fMRI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "d65b00e51e3114dac528df688675f81550d830b71b489b092d8dcc8c4691d5a0", "task_id": "ncb21-task-e15a74e2e1f75001"}
{"benchmark_case_id": "ncb-scientific-cfe09363aec199e4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q040", "covariates": [], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Default_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "cfe09363aec199e4d87cfd179508934aa0a694e2ac85f122d79bab05a56bf5ba", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "6a4dc9064b09c7072d2ebd1f18d158dd9de28db5c64f9b5312460d490e6899b0", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fe02b61f8be7f79c488b5f3c770fa296ca58555ba70789fce60ae7b50516eb18", "task_id": "ncb21-task-e1c38e33b7e80abc"}
{"benchmark_case_id": "ncb-scientific-23e29f207b2ce118", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_fc_abide2_abcd", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "fMRI-FC", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For ASD case-control FC difference in fMRI-FC, using ABIDE2 as discovery and ABCD as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "23e29f207b2ce118eb82e467460690afed63ed3a697ca7d5dfef098e03af6fdd", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c", "ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48"}, "partition_paths": ["ABCD_REP", "ABIDE2_DISC"], "question_sha256": "11ae38191c89ac95c09ea91b8f2be1345ff0c3caca32d471c878afa4fb058a31", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c2dc7c0d13f22cd45cb6cd03fbc2fad6bcb0106a48b580e2b97b0e6e6acad1bb", "task_id": "ncb21-task-e21152f351d0222a"}
{"benchmark_case_id": "ncb-scientific-55457edaa703fbe4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_37741308_pmid37741308_asd_fc_groupdiff", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "fMRI-FC", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded ASD diagnosis versus typically developing controls effect on resting-state functional connectivity alterations in fMRI-FC, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "55457edaa703fbe4b0e3548c6732e7f7dc35b0535beed7336e617f077b9a8172", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "a9a62d5037edfd7c12fc949bdd83959bd8a4663b5fdb80b542453e6f2a4985ba", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a8006a00da888baecfcf1add9ab85ef03c9a4ec8e9053710647fe90564b68b38", "task_id": "ncb21-task-e2843aea25f07618"}
{"benchmark_case_id": "ncb-scientific-67bed34632da1fbb", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "sex_fc_abcd_hcp", "covariates": ["age", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "M", "control": "F", "var": "sex"}, "outcome": "fc_fc_", "predictor": "sex", "region_set": "fMRI-FC", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.2, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For sex association with FC descriptors in fMRI-FC, using ABCD as discovery and HCP as replication, test the claim with expected direction two_sided and adjust for age;site when available.", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "67bed34632da1fbb2023a71e2192bb667fab4f85ea9c595480a539a7e23aae50", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["ABCD_DISC", "HCP_REP"], "question_sha256": "3aaa1f1809b8c707ef7e67b7db358ba1992e07a60225fa069bc2236d5096e2fa", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1f3f68503dd7b955bd9d971a139be9c9fbac4071ffdfba3c5462f602a8160dac", "task_id": "ncb21-task-e2e0ded9afa86172"}
{"benchmark_case_id": "ncb-synthetic-stress-242d47d3594f6864", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_hcp_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_hcp_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_hcp_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "242d47d3594f6864a140fedd4f24bfa945df1f12464e355a0274106540d95ad0", "dataset_id": "neg_random_label_hcp_s2", "discovery_cohort": "neg_random_label_hcp_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_hcp_s2_DISC": "bccffde5f763144fa3e50a6f8bfcea21dd0b2bc293f8e9846a322abd2bfc6add", "neg_random_label_hcp_s2_REP": "b52e18cb5a6625b08e2f397abe90521f66ff8553ec02b5bd48c47d0c85b9ffc2"}, "partition_paths": ["neg_random_label_hcp_s2_DISC", "neg_random_label_hcp_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_hcp_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "9bdc5709c545b48960e27b6578dbea73c2d3c706e6dd25e1097eb1f953352971", "task_id": "ncb21-task-e2f0f08268be3fa0"}
{"benchmark_case_id": "ncb-scientific-548cb9ea8bd9f8de", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q011", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_Cont", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_Cont differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "548cb9ea8bd9f8debed81d65b27010ba68443f8389de280f24e0a60133bfd4ba", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "9395aaf6f2c356453d1ae8c8ad57665df220feba99a1498c05afaa14107b8041", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fd9bb6d6be959f2fe86bf79ece42f4b3102d6a452f6c0cc559c946544ed68d52", "task_id": "ncb21-task-e356e42f1f57342d"}
{"benchmark_case_id": "ncb-external-transfer-f58df52cceca9d39", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_mci_pericalcarine", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "MCI", "control": "CN", "var": "dx"}, "outcome": "smri_pericalcarine", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_pericalcarine negative for MCI compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f58df52cceca9d39f9fb0be057d9e9c10ebcb6863e2a062a8847bdca42e77de9", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "ba27ae305e5d2673bb2d612fb3b9f4afb097ca5547af6df938e19c60589c4f69", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "cba2622fbd098600f8655be0e5b2f48af34c9eabcbb4d3e9ac8567927b10865c", "task_id": "ncb21-task-e3df98fc3f59953d"}
{"benchmark_case_id": "ncb-scientific-23b8d8c0265298fd", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q033", "covariates": [], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across BSNIP2_DISC and BSNIP2_REP, is the SZ-versus-HC contrast for fc_mean_positive directionally consistent with lower values in SZ in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "23b8d8c0265298fd242715da197614417003ea5efbb70bf6b292cb27ea990f0d", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23"}, "partition_paths": ["BSNIP2_DISC", "BSNIP2_REP"], "question_sha256": "8ad7a82f158a2d7ce90d1f4b1e40fa635898ef732422facd8fee869099265a14", "replication_cohorts": ["BSNIP2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7fedec7ed8e4dc3d05cd7dadb1c86170d525ed083ff3d48f470d3581a11a3a16", "task_id": "ncb21-task-e410009c1d1936d2"}
{"benchmark_case_id": "ncb-synthetic-stress-c20a3d5f8e9e123f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_fbirn_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_fbirn_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_mean_positive", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_fbirn_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c20a3d5f8e9e123f2363ad80206fc2449b05c104b96938e8ce8f865f6b6b15f6", "dataset_id": "neg_random_label_fbirn_s2", "discovery_cohort": "neg_random_label_fbirn_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_fbirn_s2_DISC": "60b07cf6a7787b61697a740d2087044384ab0646bcbd14db832c942496f68196", "neg_random_label_fbirn_s2_REP": "d2d5c7bd6d5209ae0604970ab1aca4cb6c01832b13f8e8bfc75707c2d9031c1e"}, "partition_paths": ["neg_random_label_fbirn_s2_DISC", "neg_random_label_fbirn_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_fbirn_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f85e3a0c0a46ea2b721897baa4748358f5f8a54831785f3e38cfc713bf840360", "task_id": "ncb21-task-e59d10d789ffaf66"}
{"benchmark_case_id": "ncb-scientific-7cb3fe4a5738fae5", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q001", "covariates": [], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 1.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_DISC, is schizophrenia diagnosis (SZ vs HC) associated with lower fc_mean_positive in an unadjusted group comparison with dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "7cb3fe4a5738fae59ad565ce7ad320774954e407c9d8edcbc6f05c4bb1287017", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23"}, "partition_paths": ["BSNIP2_DISC", "BSNIP2_REP"], "question_sha256": "e6e102f113b269f763eab83986c910eb619c569bf94e26fb7d502e643c9f9c56", "replication_cohorts": ["BSNIP2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7fedec7ed8e4dc3d05cd7dadb1c86170d525ed083ff3d48f470d3581a11a3a16", "task_id": "ncb21-task-e64e38fc45ab30a8"}
{"benchmark_case_id": "ncb-scientific-2ddc5b5c1ef8b93a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_010", "covariates": ["sex", "phen_fluid_intelligence", "site"], "discovery_cohort": "UKB_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_Limbic_Limbic_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_intelligence", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In UKB_DISC, with replication in UKB_REP, is higher age associated with altered limbic within-network connectivity (fc_fc_Limbic_Limbic_z), adjusting for sex and cognition?", "replication_cohorts": ["UKB_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2ddc5b5c1ef8b93a0a9b11866e80d51afc5a4f22daaf095759d71baeefc4e50b", "dataset_id": "UKB", "discovery_cohort": "UKB_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"UKB_DISC": "8f50d0d10f4265b3538407235a0af91a7bb4d1a733daea42a655d4931e0bfdd3", "UKB_REP": "6da6a67cb610290a28f97b077dd2aa0e82c39161e4b3c622857cb54843df2357"}, "partition_paths": ["UKB_DISC", "UKB_REP"], "question_sha256": "d95acff18dec0eb0cc02e157b5c1d9312cc99ab507e81acc1c62c9c5446cbd61", "replication_cohorts": ["UKB_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5ed73df37eaa39c9cbcc584b4ef6d59899f34627341c72d82f1155e4e05cc134", "task_id": "ncb21-task-e69cb146fb7350c6"}
{"benchmark_case_id": "ncb-scientific-ba299f6826289883", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "sz_fc_mean_abs_cobre_fbirn", "covariates": ["age", "sex", "site"], "discovery_cohort": "COBRE_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For SZ reduced mean absolute FC in fMRI-FC, using COBRE as discovery and FBIRN as replication, test the claim with expected direction negative SZ minus HC on fc_mean_abs and adjust for age;sex when available.", "replication_cohorts": ["FBIRN_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "ba299f6826289883e4daa74fa09ab631467ffc5d4032e7a7f330ebbddd782bc0", "dataset_id": "COBRE", "discovery_cohort": "COBRE_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"COBRE_DISC": "f53b3405d06487a9d268b89165605cc0ed60d2c3a68e41f8ebe73660d9916d79", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a"}, "partition_paths": ["COBRE_DISC", "FBIRN_REP"], "question_sha256": "6dc660eb115b8567babb0efbb128481762eda0174302a2dc5c791c7e412315c5", "replication_cohorts": ["FBIRN_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "06f6c06f61d12ba41f9edaffd5ddd520005aaab0eac6469eff6067812b325333", "task_id": "ncb21-task-e74a3902d3daab80"}
{"benchmark_case_id": "ncb-synthetic-stress-4d6f32ae88b34ae5", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_abcd_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_abcd_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Vis", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_abcd_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "4d6f32ae88b34ae5198791150792e517d18b50a760361ac0f9cf8e55246e91e7", "dataset_id": "neg_p_fishing_abcd_s3", "discovery_cohort": "neg_p_fishing_abcd_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_abcd_s3_DISC": "b5ce815122508bae5b1b68126d4e336d1b66f1f800e06a53ba2bf68038c1b73e", "neg_p_fishing_abcd_s3_REP": "3e7011bbb19eae92d29a791943c047180e6ac0c5b228638ede4245604fda2f38"}, "partition_paths": ["neg_p_fishing_abcd_s3_DISC", "neg_p_fishing_abcd_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_abcd_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "e0a3871e6b91d6ef917deeba8f0e508f28408ea467f7f89aa98613f2b7ef8b60", "task_id": "ncb21-task-e8250a543d95d863"}
{"benchmark_case_id": "ncb-scientific-0b054fd85acaa063", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q037", "covariates": ["age", "sex", "site"], "discovery_cohort": "OASIS3_fMRI_DISC", "estimand": {"direction": "negative", "group": {"case": "2", "control": "0", "var": "dx"}, "outcome": "fc_fc_Default_Default_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_fMRI_DISC, with OASIS3_fMRI_REP as a replication cohort, is diagnosis code 2 associated with lower fc_fc_Default_Default_z than diagnosis code 0, adjusting for age and sex?", "replication_cohorts": ["OASIS3_fMRI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0b054fd85acaa06382e368b06e24cb23876d673dda29faac3b690645e449b6d5", "dataset_id": "OASIS3_fMRI", "discovery_cohort": "OASIS3_fMRI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_fMRI_DISC": "7b701bee5bf1a2e4ded9c29c25ca16bc6ef6980169d9873326b362e29ecfa14d", "OASIS3_fMRI_REP": "b3ca261941658ec5a84c1f6f268e2261777e1bcd23bf28c7d2abe42d646aa786"}, "partition_paths": ["OASIS3_fMRI_DISC", "OASIS3_fMRI_REP"], "question_sha256": "bb0702c42caf974ef7f34c2f9d387c0bf6e1c67a9e7c41134334a9af131dea6b", "replication_cohorts": ["OASIS3_fMRI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b8b4ef90332019d8a52137f316a51b0fb1205f22805b88155bdc0003dc62b925", "task_id": "ncb21-task-e84b490f18a61545"}
{"benchmark_case_id": "ncb-scientific-73e0f34188f4c613", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q005", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Default_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx.notna()", "question": "In ABCD_DISC, excluding missing dx, is ADHD status (dx=1.0 vs dx=0.0) associated with altered within-Default connectivity (fc_fc_Default_Default_z), with no additional covariates, and is the association observed in ABCD_REP?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "73e0f34188f4c613bbaf75216cae99010b0947ca6e64f339d66544a75dcdd5d4", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "0aa3a5fe4a0d6337eea2c5c42d79239d490bd5e5086a52fbcb02e8d2953dd2f1", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "e51da6e8884ee1613e91c288f090d3794c2010d5f7f3ea0bf3de2274362d254e", "task_id": "ncb21-task-ea4e6d849b7d65c6"}
{"benchmark_case_id": "ncb-synthetic-stress-6689cbe59e004145", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_site_confound_gsp_s2", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "neg_site_confound_gsp_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_meanthickness", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_site_confound_gsp_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6689cbe59e0041458cef81511b8664d38d0be75114fcdbc25c6f0caa1364241d", "dataset_id": "neg_site_confound_gsp_s2", "discovery_cohort": "neg_site_confound_gsp_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_site_confound_gsp_s2_DISC": "6cabeef7b5cd82eb592b1883459a46ef06b29b2ed3ce603b730d9dda553eedf2", "neg_site_confound_gsp_s2_REP": "e359668555cc65b85065b3695c0ea82dd4c483576255708e106203ab0473e2b4"}, "partition_paths": ["neg_site_confound_gsp_s2_DISC", "neg_site_confound_gsp_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_site_confound_gsp_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fbcc4e7955934b65081c9c667a5a37fc30d2efb4ec91d52f614150a3b7352aa8", "task_id": "ncb21-task-ead294555cf30b1c"}
{"benchmark_case_id": "ncb-scientific-a1da46d7f5fa792d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q049", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Across the four discovery cohorts BSNIP2_DISC, COBRE_DISC, ChineseSZ_DISC, and FBIRN_DISC, is SZ associated with lower fc_mean_positive than HC in unadjusted dx-only comparisons with no covariates?", "replication_cohorts": ["COBRE_DISC", "ChineseSZ_DISC", "FBIRN_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a1da46d7f5fa792d06b40ef905be2163aa10371959c82a12774363e09e80a844", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "COBRE_DISC": "f53b3405d06487a9d268b89165605cc0ed60d2c3a68e41f8ebe73660d9916d79", "ChineseSZ_DISC": "25886d87d5dc1da53df39d984bfa54f68aa99adbbbcb75b7d4826c4d8bdaff73", "FBIRN_DISC": "5a9a103412824c97ff34a4b7c9107198e9309be14f345c917761eb11adcdbd82"}, "partition_paths": ["BSNIP2_DISC", "COBRE_DISC", "ChineseSZ_DISC", "FBIRN_DISC"], "question_sha256": "849940a6d905eab0f21abc57eb9b71c66c1e25ab1c5041d6406fb28becad517a", "replication_cohorts": ["COBRE_DISC", "ChineseSZ_DISC", "FBIRN_DISC"], "schema_version": "2.1.0", "scientific_core_sha256": "f6ee386d644bb4c0c9961d4f1d7d079e252374a9933464dbfaf0059653711304", "task_id": "ncb21-task-eb68dfa2754f1db6"}
{"benchmark_case_id": "ncb-scientific-58864dfe748ed623", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q006", "covariates": ["age", "sex", "site"], "discovery_cohort": "BSNIP2_REP", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_abs", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In BSNIP2_REP, do SZ participants differ from HC participants in fc_mean_abs in an unadjusted comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_DISC"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "58864dfe748ed623b1e412e518eb6d075f1280ebe036bb1dc55e56e8a2aca169", "dataset_id": "BSNIP2", "discovery_cohort": "BSNIP2_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_DISC": "f60b826114673b4f649dd9e41e9f01b5d76fe3fdff3fb17ac3d13f3472068df0", "BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23"}, "partition_paths": ["BSNIP2_DISC", "BSNIP2_REP"], "question_sha256": "314e17bed9a866bce881846048b0dc2e2b32f53a9fbb3a608a0e813c19888d20", "replication_cohorts": ["BSNIP2_DISC"], "schema_version": "2.1.0", "scientific_core_sha256": "316d36f4ebdabf24d62c16f1e9ab6f02b8445d95f78aea91a0c4bf3eaba6af98", "task_id": "ncb21-task-eba5de2aec72a501"}
{"benchmark_case_id": "ncb-scientific-c865d685dc0a2c5f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q022", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_entorhinal", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_DISC, with OASIS3_REP as a replication cohort, is Dementia associated with lower smri_entorhinal than CN, adjusting for age and sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c865d685dc0a2c5f04eeb7dc04fd4ed41e08db9bc66836e61819a499843a0b59", "dataset_id": "OASIS3", "discovery_cohort": "OASIS3_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_DISC": "8a048aaff562775d7c80f7027c9d8bb56cc738b7563d25ca06af7cb33df89d31", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["OASIS3_DISC", "OASIS3_REP"], "question_sha256": "f5d8c73a9e5538cc47bcab0348b439234a57f53b31b88b1a360749270bd2dc25", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "91684ea73962378d4810a497d31e9c5d4ff40e7c677bee88082ac6ff19469054", "task_id": "ncb21-task-ed121570c699b6ea"}
{"benchmark_case_id": "ncb-external-transfer-192c0c6505c9c7e0", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_adhd_thalamus_random_label_s20260761", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "two_sided", "group": {"case": "A", "control": "B", "var": "ncb_random_group"}, "outcome": "smri_thalamus", "predictor": "ncb_random_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Random-label control matched to external_cnp_adhd_thalamus.", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "b7e590b3f843672aa68f8a9c8a3eb94f08d2fc57c5fa09deeac0be38d8512952", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "fresh", "evidence_role": "synthetic_control", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {"assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "generator_parameters_sha256": "e14b9274ae31f3a91b784ddc06b5791012d16b46534f3ee07928effdba09200c", "selected_assignment_rows_sha256": "8a2f1bc913af3c31c389de85149c3323ec42d457e8b66c120e7f69ca44120a62"}, "generator_spec": {"assignment_count": 265, "assignment_file_sha256": "0c753d3706dff1371c71291adcdf57a083b33437213f6029f6b55e542ce6a45a", "assignment_path": "data/neuroclaimbench/v2.1/external_random_control_assignments.parquet", "assignment_sha256": "8a2f1bc913af3c31c389de85149c3323ec42d457e8b66c120e7f69ca44120a62", "discovery_seed": 20260761, "group_column": "ncb_random_group", "parent_external_claim_id": "ADHD_thalamus", "replication_seed": 21260761, "seed": 20260761, "selected_assignment_rows_sha256": "8a2f1bc913af3c31c389de85149c3323ec42d457e8b66c120e7f69ca44120a62", "type": "independent_random_group_labels"}, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "29a3bfdaedf0db9e3e15204c4957260ce2cb4aba2461f907c5856820a9e828fb", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5fe75d56b59413d45a7207b491f2a36a0f874d411c68f28602dbf23f5bbcd035", "task_id": "ncb21-task-edd1f42c4a9fd59f"}
{"benchmark_case_id": "ncb-synthetic-stress-d85043ecf72b62d3", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_adhd200_s1", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_adhd200_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Cont_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_adhd200_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d85043ecf72b62d3fad0618e339c0356285712d9fb752a115021cc6b0f40f84a", "dataset_id": "neg_random_label_adhd200_s1", "discovery_cohort": "neg_random_label_adhd200_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_adhd200_s1_DISC": "78d79b623e70b477a7cdc77ad907f4dd083920a78e82ffecd351a7a388c95449", "neg_random_label_adhd200_s1_REP": "b00b5181cf82877343ff9b1e63c47b922ac4ecb8549552c566200649161db262"}, "partition_paths": ["neg_random_label_adhd200_s1_DISC", "neg_random_label_adhd200_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_adhd200_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "02a98dcef2ada2b308f8ab1f2b197632ee8c26d894a3ab098100aaeebd0c8491", "task_id": "ncb21-task-ee2760f14f38b8df"}
{"benchmark_case_id": "ncb-scientific-88422a822641e7cd", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_30833582_pmid30833582_asd_stepwise_connectivity", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "task_free_functional_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded autism diagnosis versus typically developing controls effect on stepwise sensory-to-transmodal functional connectivity in task-free fMRI functional connectivity, using ABIDE2 as discovery and ABIDE2 as replication, test the claim with expected direction two_sided and adjust for age;sex;site when available.", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "88422a822641e7cdcba6f457a4fa41387a32f9f3a60e08260ef9b6a18e716ada", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "63cd65b8854b8da56cfc9659d38234046563e6896892bfc4b961d76ed31802ac", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a3a21ca7fd85dfc675679004d6b96975942453106ddf192a789454f88cec1c98", "task_id": "ncb21-task-ef11da7859dbdd5a"}
{"benchmark_case_id": "ncb-scientific-561d93190dd22ced", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q029", "covariates": ["age", "sex", "site"], "discovery_cohort": "FBIRN_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_mean_positive", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In FBIRN_REP, is SZ associated with lower fc_mean_positive than HC in an unadjusted group comparison using dx as the only predictor and no covariates?", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "561d93190dd22ced60f31e0fd38e0faf5c987fc53b8acf69c6396133d316d230", "dataset_id": "FBIRN", "discovery_cohort": "FBIRN_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "question_sha256": "adfdf92ec3b7d82f846061a833138ee3d6955a288b1384df67e2e4e64f1d87c3", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "f22aba492cc44c028bfee04be5d919686081f202e6d334da3cfe2c86f4282989", "task_id": "ncb21-task-f04b585ffdb4ed1b"}
{"benchmark_case_id": "ncb-synthetic-stress-43acbd197355fcc4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_adni_fmri_s3", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_adni_fmri_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_DorsAttn_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_adni_fmri_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "43acbd197355fcc4eb77c497b11b94076c986f74e66def9afe20dee941916656", "dataset_id": "neg_p_fishing_adni_fmri_s3", "discovery_cohort": "neg_p_fishing_adni_fmri_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_adni_fmri_s3_DISC": "f64cf1092b0d2488c5fbc74b5f1833d5338e9780cc11b8b1991c8a00566e3b33", "neg_p_fishing_adni_fmri_s3_REP": "1d1eea691c17209fbb3d7a6ca2d4cdd9d8e37f006fe157718227161f1e840443"}, "partition_paths": ["neg_p_fishing_adni_fmri_s3_DISC", "neg_p_fishing_adni_fmri_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_adni_fmri_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "87eacc6284710aa90ce6af9d505543060eacaa212b15f22df52f637304fcf0c0", "task_id": "ncb21-task-f0d40c8f701159f4"}
{"benchmark_case_id": "ncb-scientific-8014ff72ff0a06a0", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q020", "covariates": ["age", "sex", "site"], "discovery_cohort": "ChineseSZ_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_between_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ChineseSZ_DISC, do SZ and HC participants differ in fc_between_network in an unadjusted dx-only comparison with no covariates?", "replication_cohorts": ["ChineseSZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "8014ff72ff0a06a0aa8de224052dec1b0bd5ed72ab1609e53885372944ee3b2a", "dataset_id": "ChineseSZ", "discovery_cohort": "ChineseSZ_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ChineseSZ_DISC": "25886d87d5dc1da53df39d984bfa54f68aa99adbbbcb75b7d4826c4d8bdaff73", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8"}, "partition_paths": ["ChineseSZ_DISC", "ChineseSZ_REP"], "question_sha256": "1c93b1b79453920d69cb5870800a394a6a6714aa4623666b1013c63ce7347635", "replication_cohorts": ["ChineseSZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "fb5490c0f9830bab67ec304a1909322e1353331b5565a5c9acb64000b9de418d", "task_id": "ncb21-task-f1b4943c48b52530"}
{"benchmark_case_id": "ncb-synthetic-stress-6efee680423ceb0a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_adni_s3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_random_label_adni_s3_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_fusiform", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_adni_s3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6efee680423ceb0ac9968cca6e4747faaf747870722ba1c4e9170af0ecc523fc", "dataset_id": "neg_random_label_adni_s3", "discovery_cohort": "neg_random_label_adni_s3_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_adni_s3_DISC": "edffe81c2fe551492eb060daade15470fe99490b910f45c6ab8097e34ae9babb", "neg_random_label_adni_s3_REP": "f8634bb36a9d8f52b32c5ace904406a4c9aa4ae1c4c08c9c5430827703939e16"}, "partition_paths": ["neg_random_label_adni_s3_DISC", "neg_random_label_adni_s3_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_adni_s3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "089862ae8a02e667a9b5f7b3099a2ebab22bf655322bc6091252b515363e870d", "task_id": "ncb21-task-f1cb32462976ec67"}
{"benchmark_case_id": "ncb-scientific-fa88cbf43e33f82f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q018", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_Limbic_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC, do participants with any ADHD diagnosis (dx in {1,2,3}) show altered Limbic-Default connectivity (fc_fc_Default_Limbic_z) compared with controls (dx=0), with no additional covariates, and is the result directionally consistent in ADHD200_REP?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "fa88cbf43e33f82fcef46c1858dd805b62032cbff227c248bd865d0b9f056574", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "3e90e662beb1ef3d425a7ae84472ad06809ce7db9af7a4002ad6993cc9853257", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "8842fa401b2ad25bd7c2028318d7bace4343ab78f0bcb2e4a4e85ee42da0a6a9", "task_id": "ncb21-task-f2e2f0b7031285ab"}
{"benchmark_case_id": "ncb-scientific-06e24b7117348843", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_038", "covariates": ["age", "phen_fluid_composite", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_Default_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, do females and males differ in default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for age and cognition?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "06e24b71173488433aa6f5a40a6db8bea7b0468cbafdaa0253d8d8563a1b8453", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "c51c14ab89246e0c5dc85eeba616ebd7c7a82f1294cfd72370525a2e0834ede2", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a909daee5e640e08cbd228f41f13e098e071d4c3b86034dcd01134b3df6de1c6", "task_id": "ncb21-task-f47f4ac6f0d026ab"}
{"benchmark_case_id": "ncb-scientific-19802d4080b79f2e", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q032", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_Vis", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Limbic_Vis differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "19802d4080b79f2e8f176ede52b798824d854ec76cd44f5f03a2db90b40b33bc", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "f68ebdf86b61f4ddf03be5e934baa70b054571d6a60ef6106fab704fdce6791c", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "810e1165e4d755088cab4e0d38f247f63811b6c8a40ffd9ce8b003a9effe36b3", "task_id": "ncb21-task-f521adcc4c6f9c05"}
{"benchmark_case_id": "ncb-scientific-704522685c487d81", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_022", "covariates": ["age", "sex", "site"], "discovery_cohort": "HCP_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_DorsAttn_DorsAttn_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In HCP_DISC, with replication in HCP_REP, is higher cognition associated with higher dorsal-attention within-network connectivity (fc_fc_DorsAttn_DorsAttn_z), adjusting for age and sex?", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "704522685c487d817c358b1648972cf4b93110fe504eef340f7662e1605fe2af", "dataset_id": "HCP", "discovery_cohort": "HCP_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["HCP_DISC", "HCP_REP"], "question_sha256": "33fa3ec69b7b9eec6fe26b51c3bd67b129d4b0aca9cf3fe70527eff9a3a3afcb", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "4fe70484eb4157a7d8527f5212b6cb1e6fcebbd11d246a369bf2d873aa1acf30", "task_id": "ncb21-task-f55b77723d0aed8e"}
{"benchmark_case_id": "ncb-scientific-a545812912502796", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q039", "covariates": ["age", "sex", "site"], "discovery_cohort": "OASIS3_fMRI_DISC", "estimand": {"direction": "two_sided", "group": {"case": "2", "control": "0", "var": "dx"}, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In OASIS3_fMRI_DISC, with OASIS3_fMRI_REP as a replication cohort, does fc_fc_Default_DorsAttn_z differ between diagnosis code 2 and diagnosis code 0, adjusting for age and sex?", "replication_cohorts": ["OASIS3_fMRI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a5458129125027964cfadcefcff0f19c0d3ceed68aede1f9609ffc45247c35e4", "dataset_id": "OASIS3_fMRI", "discovery_cohort": "OASIS3_fMRI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_fMRI_DISC": "7b701bee5bf1a2e4ded9c29c25ca16bc6ef6980169d9873326b362e29ecfa14d", "OASIS3_fMRI_REP": "b3ca261941658ec5a84c1f6f268e2261777e1bcd23bf28c7d2abe42d646aa786"}, "partition_paths": ["OASIS3_fMRI_DISC", "OASIS3_fMRI_REP"], "question_sha256": "3705528892a64fa460f4e855d090bd868883354897a476251e99f56202639ce3", "replication_cohorts": ["OASIS3_fMRI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "80c6f00c88e232ba741a0e2a80ac4f21b78d57de886f19e076a36262716b27b0", "task_id": "ncb21-task-f605692c83792681"}
{"benchmark_case_id": "ncb-scientific-edbf888496455e86", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "age_fc_hcpa_hcp", "covariates": ["sex", "site"], "discovery_cohort": "HCP_Aging_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_", "predictor": "age", "region_set": "functional_connectivity_network_pairs", "type": "association", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 84, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For age association with FC descriptors in fMRI-FC, using HCP_Aging as discovery and HCP as replication, test the claim with expected direction two_sided and adjust for sex;site when available.", "replication_cohorts": ["HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 84, "selection": "preregistered"}}, "contract_sha256": "edbf888496455e861ca8f5b54407ebb0720d395cc740207187e5a05b344ee94d", "dataset_id": "HCP_Aging", "discovery_cohort": "HCP_Aging_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"HCP_Aging_DISC": "47082908a7b0b17d0b8a006028dff9d08a56af3f8c6e8d08627ca3818f85a4fd", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["HCP_Aging_DISC", "HCP_REP"], "question_sha256": "c91a1d8d790ef4f8e2f064c3a063a9b44d1ef63fe96e18322fae821da3307c10", "replication_cohorts": ["HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b76e204b70991970eca86f50791d7245ce8683e0af48d559573132b582ab00b7", "task_id": "ncb21-task-f6c946fca489fd62"}
{"benchmark_case_id": "ncb-scientific-1775e0699f7d950f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q028", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "smri_ventricles", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In OASIS3_DISC, among CN participants, is older age associated with higher smri_ventricles, adjusting for sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1775e0699f7d950fdfe70ffa2494b3427fbca176a2fb9bd01c5bf5329b7dd39e", "dataset_id": "OASIS3", "discovery_cohort": "OASIS3_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_DISC": "8a048aaff562775d7c80f7027c9d8bb56cc738b7563d25ca06af7cb33df89d31", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["OASIS3_DISC", "OASIS3_REP"], "question_sha256": "7673d352e1390cc7192eb6c2ff946377a66e9b24a0fc99e47439342ab500e2f9", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "3871f231cdf9fbed5bf470b80b3da55f518a3e6ec860edfd1b78242a8189ac7e", "task_id": "ncb21-task-f6d996a2ba79a086"}
{"benchmark_case_id": "ncb-synthetic-stress-cb1ea057a92edbc7", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_abcd_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_abcd_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_SalVentAttn_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_abcd_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "cb1ea057a92edbc7dcd8e51832f16329f3a3610616766c1b7b87758ebc7469f0", "dataset_id": "neg_p_fishing_abcd_s2", "discovery_cohort": "neg_p_fishing_abcd_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_abcd_s2_DISC": "13c9fee738f91102d6114bf5d81b3704a7b576016e7f169c619becab80f31e61", "neg_p_fishing_abcd_s2_REP": "3ed8474cf0ff5de5ca2bd844410cdb738d04f3d158f971a91e819deb18f4a0a2"}, "partition_paths": ["neg_p_fishing_abcd_s2_DISC", "neg_p_fishing_abcd_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_abcd_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b074a37fea2b0b68043a46edfb790b87955756d8a4019f32b774bbd840df5b41", "task_id": "ncb21-task-f75439cd0cc1cf1d"}
{"benchmark_case_id": "ncb-scientific-0efe8c9435d8ffdf", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_048", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "fc_fc_Default_DorsAttn_z", "predictor": "phen_fluid_composite", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "cohort in [\"HCP_DISC\", \"HCP_REP\"] or dx == \"0.0\"", "question": "Across ABCD_DISC and HCP_DISC, with replication in ABCD_REP and HCP_REP, is higher cognition associated with lower default-mode to dorsal-attention connectivity (fc_fc_Default_DorsAttn_z), adjusting for age and sex within each cohort and restricting ABCD to dx=0.0?", "replication_cohorts": ["HCP_DISC", "ABCD_REP", "HCP_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0efe8c9435d8ffdf5e3a10cd931fb791519373a7a547403b10409137517788bb", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c", "HCP_DISC": "4bfd66afa7e3af1ad63ed1a3d1fdc1662e370064e97e927de95b8f783b7886a8", "HCP_REP": "0cc8dc280e6a961585c8c2c53414db8d8cb581c59cf2beaef3e3731c5eca9eba"}, "partition_paths": ["ABCD_DISC", "ABCD_REP", "HCP_DISC", "HCP_REP"], "question_sha256": "eff33b6c00975fef43f84b9f18b7e38e6bd5b0b73bb12d8e31c36dd245908097", "replication_cohorts": ["HCP_DISC", "ABCD_REP", "HCP_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7cf8f940cd4314ae7eafd03b4048314ce79316c593b8bfa18bd4ed766d57d2e9", "task_id": "ncb21-task-f77afb2c1b6beb4b"}
{"benchmark_case_id": "ncb-scientific-caeb5a6d248ba33c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q033", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_SalVentAttn_SalVentAttn", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_SalVentAttn_SalVentAttn differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "caeb5a6d248ba33c770c82b3dc6515580c3efad63440adbbb4688d39731a3c41", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "9f52f9300780dfa9ca8f23c5fee863243fe3d314812c4e46c8ca6a3db4d3b107", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "cb7cd847e1f3d937368cbef16af739b74c4188b1c7861d075cb5c6de7fc1d117", "task_id": "ncb21-task-f78467ff31f5d941"}
{"benchmark_case_id": "ncb-synthetic-stress-f9b3b69c40a65738", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_cobre_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_random_label_cobre_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_mean_positive", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_cobre_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "f9b3b69c40a657389a8bea87a007f6b474a971f674d4bed26975fc3fe1cda273", "dataset_id": "neg_random_label_cobre_s2", "discovery_cohort": "neg_random_label_cobre_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_cobre_s2_DISC": "ded0579c062016fa1e6178ed3f8ab1ca39887c7553dddaa517e0278bb3abfac0", "neg_random_label_cobre_s2_REP": "f4c159def547f0ba6181c6e93cd3735e106c14f4282cea7d80cc12866af0ef5b"}, "partition_paths": ["neg_random_label_cobre_s2_DISC", "neg_random_label_cobre_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_cobre_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c8f3defc6e2d575f1c134c78631763f81098018fe1f73a88a05bdb069ce44782", "task_id": "ncb21-task-f7cacd8521a955a0"}
{"benchmark_case_id": "ncb-external-transfer-5fb11c517888b8d9", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_mci_hippocampus", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "MCI", "control": "CN", "var": "dx"}, "outcome": "smri_hippocampus", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_hippocampus negative for MCI compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "5fb11c517888b8d924cd8c19b347ccae0ef25f2697b27fdb07d9a8351a9baab6", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "732c2064c4edc92cc22ed5b4500af374e55068b627f59ba4428179335064ef5c", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "3bc5219bbd272aee8d64d229c0f70ae7f06f04d4762dbbbe81a9b09280dbc4ec", "task_id": "ncb21-task-f88153ab9343b73e"}
{"benchmark_case_id": "ncb-scientific-c823298f5f12df8a", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "asd_q041", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABIDE2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Cont_DorsAttn_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABIDE2_DISC, with replication assessed in ABIDE2_REP, does fc_fc_Cont_DorsAttn_z differ between dx=1 and dx=2 participants using dx as the predictor and no additional covariates?", "replication_cohorts": ["ABIDE2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "c823298f5f12df8af07efc39e57413ee6b375c5f9f95bf060e712101c70c15cd", "dataset_id": "ABIDE2", "discovery_cohort": "ABIDE2_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABIDE2_DISC": "8d4c8e9e44d4ff95a0c33407ff712892a8f11d59771435ba90a530d87bc2ed48", "ABIDE2_REP": "a640be99817a96cbd7826a0360d39665a626da64bba1da2b1ebcce24ed71310b"}, "partition_paths": ["ABIDE2_DISC", "ABIDE2_REP"], "question_sha256": "82b424dd24392485dfe0585b2ac8274ad9969c38a52bb25afb4c2cb29a0b96dc", "replication_cohorts": ["ABIDE2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "ee197ababc2ae9042952f1fd8de0b47a4193ab15f3f80c00617bbda61704bbe2", "task_id": "ncb21-task-f881acc3dcf78298"}
{"benchmark_case_id": "ncb-scientific-eafa675a2857a0cb", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "normative_fmri_034", "covariates": ["sex", "phen_fluid_composite", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "positive", "group": null, "outcome": "fc_fc_Default_Default_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "phen_fluid_composite", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0.0\"", "question": "Among ABCD participants with dx=0.0, in ABCD_DISC with replication in ABCD_REP, is higher age associated with higher default-mode within-network connectivity (fc_fc_Default_Default_z), adjusting for sex and cognition?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "eafa675a2857a0cb78b9514e4388964a9404eeef0cb89fc7b7b10da646cce92b", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "c59ac3b2e7a124a06b2fa9fe10622c08911f9c0facc354f62cbeee13f85f9539", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7e6f3a8cbcbdf17c40b7875edb746f4ddcd5d13ac201521f69934bc26f35be28", "task_id": "ncb21-task-f88dd656c19b1fdc"}
{"benchmark_case_id": "ncb-external-transfer-6e7550292e8dbaff", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_nacc_ad_precentral", "covariates": ["age", "sex", "eTIV"], "discovery_cohort": "NACC_EXTERNAL_DISC", "estimand": {"direction": "negative", "group": {"case": "AD", "control": "CN", "var": "dx"}, "outcome": "smri_precentral", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In NACC, is smri_precentral negative for AD compared with CN?", "replication_cohorts": ["NACC_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "6e7550292e8dbaffab7a229a2ba0bc03e8ef2a064499fe89097f4d6d9624eab8", "dataset_id": "NACC", "discovery_cohort": "NACC_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"NACC_EXTERNAL_DISC": "a3e6f1609ea823c9216310eaea1cf3e54443ed385d8f2c4ccb0374907756646b", "NACC_EXTERNAL_REP": "4cc03f072ec07c42f4ceaa18a43bd2065e0d5c508c7d70b6115b8ccc60ee1062"}, "partition_paths": ["NACC_EXTERNAL_DISC", "NACC_EXTERNAL_REP"], "question_sha256": "d64de9d68f1672c913da6ca1dfe2ae02c5d2c5c243535c78b112ae72f0809a01", "replication_cohorts": ["NACC_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "06e7014869b26d9d4c7c092077c80a2c310a6b2640100765f7d40915381cf4de", "task_id": "ncb21-task-f8930ea35c0e7afa"}
{"benchmark_case_id": "ncb-scientific-9346832a3ea94fed", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_entorhinal_atrophy_adni_oasis3", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_entorhinal", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For AD entorhinal atrophy in sMRI, using ADNI as discovery and OASIS3 as replication, test the claim with expected direction negative and adjust for age;sex;eTIV when available.", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "9346832a3ea94fed1779e67d24dd063322531f7532512b5576692279e9c5150b", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["ADNI_DISC", "OASIS3_REP"], "question_sha256": "e9bfbb45155f52912fb21fcec0d272b69e1e9c2ff9663b0d273b03591ce6fa7c", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "25dba1c44642c28cf83b9b72ec3b64bb604d2a1bc1203762b29af79c3a25c8b4", "task_id": "ncb21-task-f8c1d12a12345e3a"}
{"benchmark_case_id": "ncb-external-transfer-d9c2200f2c768244", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "external_cnp_bd_lateralventricle", "covariates": ["age", "sex"], "discovery_cohort": "ds000030_EXTERNAL_DISC", "estimand": {"direction": "positive", "group": {"case": "BIPOLAR", "control": "CONTROL", "var": "dx"}, "outcome": "smri_lateralventricle", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In CNP, is smri_lateralventricle positive for BIPOLAR compared with CONTROL?", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "d9c2200f2c768244d92d189817b7ffc77290ced3c9e8d3314da7aeaaa4e90944", "dataset_id": "ds000030", "discovery_cohort": "ds000030_EXTERNAL_DISC", "evidence_freshness": "previously_queried", "evidence_role": "external", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ds000030_EXTERNAL_DISC": "232132a84602d2e002eff364fa44085a7d831aca45cc3db13afd94a377e6b66e", "ds000030_EXTERNAL_REP": "e722d3550084f1d8aed04e44b0e6662f7a7d342b8abd67c8fc52eec91e78415f"}, "partition_paths": ["ds000030_EXTERNAL_DISC", "ds000030_EXTERNAL_REP"], "question_sha256": "623e6810bddc6d55e0f5bb9b1d7a50d030da88be51ec27b0c8eeee4f015bf722", "replication_cohorts": ["ds000030_EXTERNAL_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "1627c0411879d439527acc1de22f6f58b5fbeaf359095659e6a87b41610c6e67", "task_id": "ncb21-task-f92f5f7269378e53"}
{"benchmark_case_id": "ncb-scientific-c8acae9508ef35fd", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "pubmed_31265198_pmid31265198_fc_adhd_vs_tdc", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_", "predictor": "confirm_dx", "region_set": "resting_state_functional_connectivity", "type": "group_diff", "unit": "brainwide"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 190, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.5, "harmonize": "combat", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "For literature-grounded ADHD patients versus typically developing controls effect on seed-based functional connectivity in resting-state fMRI functional connectivity, using ABCD as discovery and ADHD200 as replication, test the claim with expected direction negative and adjust for age;sex;site when available.", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 190, "selection": "preregistered"}}, "contract_sha256": "c8acae9508ef35fd71e17be422a96ff94cda16d53561647f67cc34bf3fb5e2dc", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ABCD_DISC", "ADHD200_REP"], "question_sha256": "496881fa0a06016a7fe25e29742550dbf996ec2b05312029a2998e312a09c937", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7168dd728c1670843341d19e4c97ff0a5c3eca44d33cc9bd4528b2bfdf4a1bf1", "task_id": "ncb21-task-f9773dc8fdf57d18"}
{"benchmark_case_id": "ncb-synthetic-stress-2724233ad72644a4", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_underpowered_abcd_s1", "covariates": ["age", "site"], "discovery_cohort": "neg_underpowered_abcd_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "F", "control": "M", "var": "sex"}, "outcome": "fc_fc_Default_SalVentAttn_z_z", "predictor": "sex", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_underpowered_abcd_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "2724233ad72644a4edc54b420e469d5c12fe7c9cd82c8b30f0ecd3658a8c08c8", "dataset_id": "neg_underpowered_abcd_s1", "discovery_cohort": "neg_underpowered_abcd_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_underpowered_abcd_s1_DISC": "03d93978fe0f3227ae4ade2418e88aca27088ca7ff426c7f8689660125c617fe", "neg_underpowered_abcd_s1_REP": "2ad5a81fb883b881e0cde277d8a6e6d28e9ca7add809f6676a08f116800e1986"}, "partition_paths": ["neg_underpowered_abcd_s1_DISC", "neg_underpowered_abcd_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_underpowered_abcd_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "8a517322048b40bc0b1d1537c160d44898daa22fcba204836cbe87b334829921", "task_id": "ncb21-task-f97fc234a7ca2e8f"}
{"benchmark_case_id": "ncb-synthetic-stress-2cdcd1655db50299", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_p_fishing_adhd200_s2", "covariates": ["age", "sex", "site"], "discovery_cohort": "neg_p_fishing_adhd200_s2_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "fc_fc_Cont_Default_z_z", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_p_fishing_adhd200_s2_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 24, "selection": "discovery_only"}}, "contract_sha256": "2cdcd1655db5029902be303519de9418f6552625c8f7613cc5fc064e3be686bd", "dataset_id": "neg_p_fishing_adhd200_s2", "discovery_cohort": "neg_p_fishing_adhd200_s2_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_p_fishing_adhd200_s2_DISC": "92070e6f65d750e663460c31167b5a7f15e6bf362758b175ff11e17865499388", "neg_p_fishing_adhd200_s2_REP": "c2773779a8dda2a11b695e5fd659aff503d36026be56c6e06d653d211a60eaf5"}, "partition_paths": ["neg_p_fishing_adhd200_s2_DISC", "neg_p_fishing_adhd200_s2_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_p_fishing_adhd200_s2_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "145f965309004e86a0ee5c6a86f5c66eae3f6df6cebe47a3837c0fb007196ccd", "task_id": "ncb21-task-fb299b748b862fe9"}
{"benchmark_case_id": "ncb-scientific-1b8a8b0d4ec2f528", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q001", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "ADNI_DISC", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "smri_hippocampus", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADNI_DISC, with ADNI_REP as a replication cohort, is Dementia associated with lower smri_hippocampus than CN, adjusting for age and sex?", "replication_cohorts": ["ADNI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "1b8a8b0d4ec2f5286857565cc3b20b69b0e31e8b7a6ef26b710a5387f2b28f93", "dataset_id": "ADNI", "discovery_cohort": "ADNI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_DISC": "7f42f7518c34775c8e5cf7c590a1fe44f226f40a7b899e71223b56ef43411663", "ADNI_REP": "56cd379d34a3e7f93f341c1014daa9b3a9146606a68d4720d4513d09e35d73b6"}, "partition_paths": ["ADNI_DISC", "ADNI_REP"], "question_sha256": "1504487b6b62f6f843c36f09dac3d721baac3e9b0d8f05b3f0e4d736f4ff2dd7", "replication_cohorts": ["ADNI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b3e19b2d6b453b9bd2df225b99dd31fb3f14519312f5f1d8b59832a9b8a4700b", "task_id": "ncb21-task-fb4489244a478c3c"}
{"benchmark_case_id": "ncb-scientific-bf6a4a4dabf8357f", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q029", "covariates": ["sex", "eTIV", "site"], "discovery_cohort": "OASIS3_DISC", "estimand": {"direction": "negative", "group": null, "outcome": "smri_wholebrain", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"CN\"", "question": "In OASIS3_DISC, among CN participants, is older age associated with lower smri_wholebrain, adjusting for sex?", "replication_cohorts": ["OASIS3_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "bf6a4a4dabf8357f31e6a07ae1504771c332c4ed81929fb895a09609631d5866", "dataset_id": "OASIS3", "discovery_cohort": "OASIS3_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_DISC": "8a048aaff562775d7c80f7027c9d8bb56cc738b7563d25ca06af7cb33df89d31", "OASIS3_REP": "62d6a63ce9976382850394883432b7f2b5e3460979250545efcf3c8be093e3d0"}, "partition_paths": ["OASIS3_DISC", "OASIS3_REP"], "question_sha256": "471346971a5ea41cfb190c9fabcbd47a7800e7ac5bf957af51dac02889ff6aba", "replication_cohorts": ["OASIS3_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5431056f103431ae8623f219ada1d4abec04b25cb89eaceb664b3c61380a9985", "task_id": "ncb21-task-fb80325a3bdd78f7"}
{"benchmark_case_id": "ncb-synthetic-stress-e2967e8bdd4698b5", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_adni_s1", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_random_label_adni_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "pet_fdg_suvr", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_adni_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "e2967e8bdd4698b597dfd8b30455256f41730ba16511350095aa8bc3c4dd8859", "dataset_id": "neg_random_label_adni_s1", "discovery_cohort": "neg_random_label_adni_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_adni_s1_DISC": "7b95292056d955736444872ba863040e7df7b3cd965121a94b0fdfbc391a5cad", "neg_random_label_adni_s1_REP": "5cd8b379d52abe9097e4ea7c154ce2929d697ee289ee0dd73fb453d4826edcad"}, "partition_paths": ["neg_random_label_adni_s1_DISC", "neg_random_label_adni_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_adni_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "7a0a9a0cfcf0e66c4b50c3622297e99d25eebb417eed9c3cc81dbcc1255a1b7b", "task_id": "ncb21-task-fc50ef79bcc881c0"}
{"benchmark_case_id": "ncb-scientific-03136ab7c6bb7990", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q034", "covariates": ["age", "sex", "site"], "discovery_cohort": "ABCD_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Default_SomMot_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 0.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ABCD_DISC and ABCD_REP separately, excluding missing dx, do ADHD cases (dx=1.0) differ from controls (dx=0.0) in Default-Somatomotor connectivity (fc_fc_Default_SomMot_z), with no additional covariates?", "replication_cohorts": ["ABCD_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "03136ab7c6bb7990d987f647394f6865d014527a752393660750e24e0cd5b01d", "dataset_id": "ABCD", "discovery_cohort": "ABCD_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ABCD_DISC": "4cbdd68c4e5d2551235f70923ba2c1e3186fa274facbefb7965eb4c01b79105c", "ABCD_REP": "96b7ad18b4986aa95be24a26957a984c72f01833b3dcd197f01a9c808d424d9c"}, "partition_paths": ["ABCD_DISC", "ABCD_REP"], "question_sha256": "16da99455100e73d7cbf0d1821891a26f50e588e4113c7461a6afac868eb9e9f", "replication_cohorts": ["ABCD_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "b9998b52069e6ce1e9294fcd17aaa48a5f6eeffc72441fe597ab4c0e57fa86a9", "task_id": "ncb21-task-fd19e9541079da97"}
{"benchmark_case_id": "ncb-synthetic-stress-feb2bcefb03564db", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_gsp_s1", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_random_label_gsp_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_hippocampus_rh", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_gsp_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "feb2bcefb03564db53cc97d9b7dd7655ee239ebaff78db6be07fe5b4bd8f0db2", "dataset_id": "neg_random_label_gsp_s1", "discovery_cohort": "neg_random_label_gsp_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_gsp_s1_DISC": "ad50738115dc32f8325d8dad53752f6537ff9b93477e251c9bce69494ce8ac08", "neg_random_label_gsp_s1_REP": "6dc51a29a19a13fae9ec1a70515407cb66313b0288f2fd3e8d38f0f773e0fb9d"}, "partition_paths": ["neg_random_label_gsp_s1_DISC", "neg_random_label_gsp_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_gsp_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "58a3df976374ea2a3ef08ae36057ce7ed478dd5e3e9c6f9485954af3b17ba5de", "task_id": "ncb21-task-fd27030d97eff5a0"}
{"benchmark_case_id": "ncb-scientific-0cf9bf17a3cb10a7", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q044", "covariates": ["sex", "site"], "discovery_cohort": "OASIS3_fMRI_DISC", "estimand": {"direction": "two_sided", "group": null, "outcome": "fc_fc_Cont_Default_z", "predictor": "age", "region_set": null, "type": "association", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx == \"0\"", "question": "In OASIS3_fMRI_DISC, among participants with diagnosis code 0, does fc_fc_Cont_Default_z change with older age, adjusting for sex?", "replication_cohorts": ["OASIS3_fMRI_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "0cf9bf17a3cb10a706661b585964be67b5928087882dc93e7b80224dac8a3534", "dataset_id": "OASIS3_fMRI", "discovery_cohort": "OASIS3_fMRI_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"OASIS3_fMRI_DISC": "7b701bee5bf1a2e4ded9c29c25ca16bc6ef6980169d9873326b362e29ecfa14d", "OASIS3_fMRI_REP": "b3ca261941658ec5a84c1f6f268e2261777e1bcd23bf28c7d2abe42d646aa786"}, "partition_paths": ["OASIS3_fMRI_DISC", "OASIS3_fMRI_REP"], "question_sha256": "02d7db3556f6fc5a985b97d4310855d18f6e35d6b60b8eb7f60e9a79547a3d76", "replication_cohorts": ["OASIS3_fMRI_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "83cf598d9c82286cb22708a167293a7657c0e1a9657049d6fcfb9accb9038d74", "task_id": "ncb21-task-fd552b642761b2dd"}
{"benchmark_case_id": "ncb-scientific-a3f4263a0dce56cf", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "ad_aging_q048", "covariates": ["age", "sex", "site"], "discovery_cohort": "ADNI_fMRI_REP", "estimand": {"direction": "negative", "group": {"case": "2.0", "control": "0.0", "var": "dx"}, "outcome": "fc_fc_Cont_Default_z", "predictor": "dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": "dx in [\"0.0\", \"2.0\"]", "question": "In ADNI_fMRI_REP, excluding participants with missing diagnosis code, is diagnosis code 2.0 associated with lower fc_fc_Cont_Default_z than diagnosis code 0.0, adjusting for age and sex?", "replication_cohorts": [], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "a3f4263a0dce56cf738ebd2d271cf2f786acf25f6ab1432a96784f063e51d349", "dataset_id": "ADNI_fMRI", "discovery_cohort": "ADNI_fMRI_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADNI_fMRI_REP": "77b228db80400e42457cdc1a715f338fa645e8901922ef5f6f7c7f7d3d176c13"}, "partition_paths": ["ADNI_fMRI_REP"], "question_sha256": "19e071037357ceedd8222b71e868797a6a5d8c0b0fc9a3c80412e3c081ee348c", "replication_cohorts": [], "schema_version": "2.1.0", "scientific_core_sha256": "6190d6f1f378f912d39fce6d19e77354cd41bebe544e8e3e26d2ffb71a0cacc1", "task_id": "ncb21-task-fd6e517ddccfca52"}
{"benchmark_case_id": "ncb-scientific-23d61a93cc5dbec1", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "adhd_q039", "covariates": [], "discovery_cohort": "ADHD200_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_fc_Limbic_Vis_z", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "combat", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In ADHD200_DISC and ADHD200_REP separately, is any ADHD diagnosis (dx in {1,2,3}) versus control (dx=0) associated with altered Limbic-Visual connectivity (fc_fc_Limbic_Vis_z), with no additional covariates?", "replication_cohorts": ["ADHD200_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "23d61a93cc5dbec1201748d85be106d526d3eb4bc7a44e09052d181d46ae110f", "dataset_id": "ADHD200", "discovery_cohort": "ADHD200_DISC", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"ADHD200_DISC": "2ed4e2ddb4d8a3845dbec23c0b31652d26fdefe209e61fc4cdd3b636ebabb4fd", "ADHD200_REP": "1fd15e9671bb90a6163ed83e0624771c3641cbc001580565f7bc73f8e79cd533"}, "partition_paths": ["ADHD200_DISC", "ADHD200_REP"], "question_sha256": "443dbcf9d09f16243dbaca1f851098003f4ae5640f251b4c1b5a0812be068eb3", "replication_cohorts": ["ADHD200_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "c4b7c90df68fab68b74f9766d988c1577a56593f040d65224e3188511190504b", "task_id": "ncb21-task-fd94e34ea1090527"}
{"benchmark_case_id": "ncb-scientific-622e97baf8eece3c", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "psychosis_q015", "covariates": [], "discovery_cohort": "COBRE_REP", "estimand": {"direction": "negative", "group": {"case": "case", "control": "control", "var": "confirm_dx"}, "outcome": "fc_within_network", "predictor": "confirm_dx", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": true, "require_covariates": []}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.0, "region_replication_frac_min": 1.0, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "In COBRE_REP, is fc_within_network lower in SZ than HC in an unadjusted dx-only comparison with no covariates?", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "622e97baf8eece3cc6a62615addca82592c24a5eb42cd164d81459a0d041eaab", "dataset_id": "COBRE", "discovery_cohort": "COBRE_REP", "evidence_freshness": "unknown", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"BSNIP2_REP": "5a68458b6ca1d3ceb62243f2dcf1fda0209a9d2685669530b7e4c5f279a32f23", "COBRE_REP": "4a81a6fb00f3834982866da08d40f58816c7907a2c62838ae1fad68fd5bb18dc", "ChineseSZ_REP": "9c94c02e8066411af69f22387e526434c8c412c6df30ff250b1c7bc75f5514a8", "FBIRN_REP": "132788e0b0576e4f01ac0ac8dcbb232f2f105aea4693833ef74a59a45118b33a", "Olin_SZ_REP": "d7bef7b3dc92844bbfc9976c601ed84734ccd0a9b19af3571dddda43dc156167"}, "partition_paths": ["BSNIP2_REP", "COBRE_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "question_sha256": "cd3601dfd0043d88bca145b4600da4e750740d909e5ebba12c6d2b4749b0d7ae", "replication_cohorts": ["BSNIP2_REP", "ChineseSZ_REP", "FBIRN_REP", "Olin_SZ_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "a626fe8c7acf49642db12b8ed6ac78e955ad07b699f245210ab49bc66f6666a5", "task_id": "ncb21-task-fee6640bb16b3dd4"}
{"benchmark_case_id": "ncb-synthetic-stress-577eca459126d08d", "code_sha": "f471d4572413a58944f93300266e24c1a93b01ec", "contract": {"claim_id": "neg_random_label_oasis3_s1", "covariates": ["age", "sex", "eTIV", "site"], "discovery_cohort": "neg_random_label_oasis3_s1_DISC", "estimand": {"direction": "two_sided", "group": {"case": "case", "control": "control", "var": "bench_group"}, "outcome": "smri_fusiform", "predictor": "bench_group", "region_set": null, "type": "group_diff", "unit": "scalar"}, "gates": {"confound": {"motion_check": false, "require_covariates": ["age", "sex", "eTIV", "site"]}, "multiplicity": {"alpha": 0.05, "family_size": 1, "method": "fdr_bh"}, "multiverse": {"min_fraction_consistent": 0.6}, "power": {"min_power": 0.8, "ref_effect": null}, "replication": {"alpha": 0.05, "dice_min": 0.0, "harmonize": "none", "pattern_corr_min": 0.5, "region_replication_frac_min": 0.5, "require_ci_overlap": false, "require_same_sign": true}}, "inclusion": null, "question": "Programmatic synthetic known-null/fragile negative stress claim.", "replication_cohorts": ["neg_random_label_oasis3_s1_REP"], "reporting_language_allowed": ["confirmed", "non_replicated", "under_powered", "fragile"], "search_provenance": {"declared": true, "family_size": 1, "selection": "preregistered"}}, "contract_sha256": "577eca459126d08d1d55afac38663593c07a4e986bb18fb18abae2e7b24b6287", "dataset_id": "neg_random_label_oasis3_s1", "discovery_cohort": "neg_random_label_oasis3_s1_DISC", "evidence_freshness": "previously_queried", "evidence_role": "source", "gate_policy_version": "776c433b73972e491366326f2387f0f6de94927293bd420bd55d0c2dc155baec", "generator_artifact_hashes": {}, "generator_spec": null, "partition_hashes": {"neg_random_label_oasis3_s1_DISC": "bb993d1867dac434fb9542a1e5483f8bef1f2eb71635ad4b1ddbfaae2bbe4d31", "neg_random_label_oasis3_s1_REP": "2991a3c1f3aec0c77405f0322c3785918b001b1f3a225b73e384e4251c4af827"}, "partition_paths": ["neg_random_label_oasis3_s1_DISC", "neg_random_label_oasis3_s1_REP"], "question_sha256": "bc9561cf36451f71dc170eed589166cd8b983c6f180f4002d802967d428dd31f", "replication_cohorts": ["neg_random_label_oasis3_s1_REP"], "schema_version": "2.1.0", "scientific_core_sha256": "5b76fea2596ff53b7baebb8418d57777587ab73d29ba2941296091594033ef80", "task_id": "ncb21-task-ffe27a6acf36c2a5"}