{
  "checked_utc": "2026-10-01T18:17:21.393082+00:00",
  "endpoint": "https://www.ebi.ac.uk/interpro/matches/api/matches",
  "seed": 20261001,
  "unique_queries": 6688,
  "cohorts": {
    "frozen_training_endpoint_pool": {
      "population": 899427,
      "source": "/mnt/disk3/zn10/gpbridge_enzyme_dataset/motif_scratch_20260926/training_index/union_cluster_input.fasta",
      "queried": 3000,
      "successful": 3000,
      "technical_errors": 0,
      "counts": {
        "found": 3000,
        "any_match": 3000,
        "traditional_match": 3000,
        "pfam_match": 2981,
        "selected_traditional_match": 2993,
        "selected_site_annotation": 2486,
        "selected_binding_site_annotation": 1848,
        "neural_only": 0
      },
      "fractions": {
        "found": 1.0,
        "any_match": 1.0,
        "traditional_match": 1.0,
        "pfam_match": 0.9936666666666667,
        "selected_traditional_match": 0.9976666666666667,
        "selected_site_annotation": 0.8286666666666667,
        "selected_binding_site_annotation": 0.616,
        "neural_only": 0.0
      },
      "api_found_wilson95": [
        0.9987211512746742,
        1.0000000000000002
      ]
    },
    "accepted_filter_study_panel": {
      "population": 22791,
      "queried": 3000,
      "successful": 3000,
      "technical_errors": 0,
      "counts": {
        "found": 3000,
        "any_match": 2999,
        "traditional_match": 2997,
        "pfam_match": 2928,
        "selected_traditional_match": 2968,
        "selected_site_annotation": 2309,
        "selected_binding_site_annotation": 1604,
        "neural_only": 2
      },
      "fractions": {
        "found": 1.0,
        "any_match": 0.9996666666666667,
        "traditional_match": 0.999,
        "pfam_match": 0.976,
        "selected_traditional_match": 0.9893333333333333,
        "selected_site_annotation": 0.7696666666666667,
        "selected_binding_site_annotation": 0.5346666666666666,
        "neural_only": 0.0006666666666666666
      },
      "api_found_wilson95": [
        0.9987211512746742,
        1.0000000000000002
      ]
    },
    "study_references": {
      "population": 692,
      "queried": 692,
      "successful": 692,
      "technical_errors": 0,
      "counts": {
        "found": 692,
        "any_match": 692,
        "traditional_match": 692,
        "pfam_match": 685,
        "selected_traditional_match": 691,
        "selected_site_annotation": 590,
        "selected_binding_site_annotation": 422,
        "neural_only": 0
      },
      "fractions": {
        "found": 1.0,
        "any_match": 1.0,
        "traditional_match": 1.0,
        "pfam_match": 0.9898843930635838,
        "selected_traditional_match": 0.9985549132947977,
        "selected_site_annotation": 0.8526011560693642,
        "selected_binding_site_annotation": 0.6098265895953757,
        "neural_only": 0.0
      },
      "api_found_wilson95": [
        0.9944794050828696,
        1.0
      ]
    }
  },
  "limitations": [
    "Random-sequence samples are estimates, not a census of the full 483-shard dataset.",
    "API presence does not imply a named ligand label or complete ligand-set coverage.",
    "InterPro-N, SignalP, DeepTMHMM and TMbed are excluded from traditional signature counts."
  ],
  "library_versions": {
    "CATH-FunFam:4.3.0": 5136,
    "CATH-Gene3D:4.3.0": 12067,
    "CDD:3.21": 4958,
    "COILS:2.2.1": 431,
    "HAMAP:2026_01": 1347,
    "MobiDB-lite:4.0": 1126,
    "NCBIFAM:20.0": 4476,
    "PANTHER:19.0": 6444,
    "PIRSF:3.10": 1460,
    "PIRSR:2025_05": 30601,
    "PRINTS:42.0": 2412,
    "PROSITE patterns:2026_01": 4040,
    "PROSITE profiles:2026_01": 2759,
    "Pfam:38.2": 10290,
    "Phobius:1.01": 7914,
    "SFLD:4": 919,
    "SMART:9.0": 2314,
    "SUPERFAMILY:1.75": 9833
  }
}