{
  "task_id": "MED3",
  "title": "Two-hit retinoblastoma, mosaic selection, and sequencing-biased genetic risk",
  "category": "Cancer genetics and Bayesian risk modeling",
  "instruction_file": "instruction.md",
  "input_data": "All parameters and equations needed for the task are embedded in instruction.md.",
  "action_schema": {
    "type": "object",
    "properties": {
      "next_sibling_recurrence_risk_given_bilateral_blood_neg": {
        "type": "number"
      },
      "offspring_retinoblastoma_risk_given_unilateral_blood_neg": {
        "type": "number"
      },
      "posterior_constitutional_given_unilateral_blood_neg": {
        "type": "number"
      },
      "posterior_embryonic_mosaic_given_bilateral_blood_neg": {
        "type": "number"
      },
      "posterior_embryonic_mosaic_given_unifocal_unilateral_blood_neg": {
        "type": "number"
      },
      "posterior_embryonic_mosaic_given_unilateral_blood_neg": {
        "type": "number"
      },
      "posterior_parental_gonadal_mosaic_given_unilateral_blood_neg": {
        "type": "number"
      },
      "problem_id": {
        "type": "string",
        "const": "MED3"
      },
      "sporadic_expected_foci_per_million_wildtype": {
        "type": "number"
      }
    },
    "required": [
      "next_sibling_recurrence_risk_given_bilateral_blood_neg",
      "offspring_retinoblastoma_risk_given_unilateral_blood_neg",
      "posterior_constitutional_given_unilateral_blood_neg",
      "posterior_embryonic_mosaic_given_bilateral_blood_neg",
      "posterior_embryonic_mosaic_given_unifocal_unilateral_blood_neg",
      "posterior_embryonic_mosaic_given_unilateral_blood_neg",
      "posterior_parental_gonadal_mosaic_given_unilateral_blood_neg",
      "problem_id",
      "sporadic_expected_foci_per_million_wildtype"
    ],
    "additionalProperties": true,
    "description": "All numerical values must be finite JSON numbers. Exact per-field domains, units and tolerances are specified by the instruction and verifier."
  },
  "external_data_required": false
}