This is DDRGK domain-containing protein 1 protein, from Mouse, contains 315 amino acids, locates in Endoplasmic reticulum.

Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) (By similarity), In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets (By similarity), Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (PubMed:28128204), Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response (PubMed:30701081), Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated transcription (PubMed:28263186), May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:28263186), Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186)


This is Homeobox protein NANOG protein, from Mouse, contains 305 amino acids, locates in Nucleus.

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal (PubMed:25825768), Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages, Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes, Acts as a transcriptional activator or repressor, Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3', Binds to the POU5F1/OCT4 promoter (By similarity), Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression, When overexpressed, promotes cells to enter into S phase and proliferation


This is Sirohydrochlorin ferrochelatase, chloroplastic protein, from Mouse-ear cress, contains 225 amino acids, locates in Plastid.

Chelates iron to the siroheme precursor, Catalyzes the last step of the siroheme biosynthesis, Unlike its counterparts in bacteria, contains an [Fe-S] cluster which is not involved directly in the enzymatic reaction, but may play regulatory role in iron, sulfur and tetrapyrrole metabolism (PubMed:15545265, PubMed:22414210), The [Fe-S] cluster is required for normal plant growth (PubMed:22414210)

Belongs to the CbiX family, SirB subfamily


This is NAC domain-containing protein 78 protein, from Mouse-ear cress, contains 567 amino acids, is membrane-bound, locates in Nucleus.

Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (By similarity), Transcripition activator associated with the induction of genes related to flavonoid biosynthesis and required for the accumulation of anthocyanins in response to high light stress (PubMed:19887540), Plays a role in the regulation of 20S and 26S proteasomes in response to high light stress (PubMed:21889048)


This is Transcription factor PIF5 protein, from Mouse-ear cress, contains 444 amino acids, locates in Nucleus.

Transcription factor acting negatively in the phytochrome B signaling pathway to promote the shade-avoidance response, Regulates PHYB abundance at the post-transcriptional level, possibly via the ubiquitin-proteasome pathway, Promotes ethylene activity in the dark, May regulate the expression of a subset of genes by binding to the G-box motif, Might be involved in the integration of light-signals to control both circadian and photomorphogenic processes, Activated by CRY1 and CRY2 in response to low blue light (LBL) by direct binding at chromatin on E-box variant 5'-CA[CT]GTG-3' to stimulate specific gene expression to adapt global physiology (e,g, hypocotyl elongation in low blue light) (PubMed:26724867)


This is Vacuolar-processing enzyme beta-isozyme 1 protein, from Rice, contains 497 amino acids, locates in Lysosome/Vacuole.

Asparagine-specific endopeptidase that may be involved in processing of proteins targeted to vacuoles, Cysteine protease required for post-translational proteolysis of seed storage proteins in the protein storage vacuole (PSV) of developing seeds, by processing of proglutelin precursor to mature glutelin subunits, thus contributing to the formation of protein crystalline structures in PSV (Ref,1, PubMed:19154227, PubMed:19933265)


This is Serine/arginine-rich splicing factor SR45a protein, from Mouse-ear cress, contains 382 amino acids, locates in Nucleus.

Probable splicing factor involved in constitutive and/or alternative splicing events, May bridge the 5' and 3' components of the spliceosome

Belongs to the splicing factor SR family, SR45 subfamily


This is NAD(P)H-quinone oxidoreductase subunit U, chloroplastic protein, from Mouse-ear cress, contains 218 amino acids, is membrane-bound, locates in Plastid.

NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain, The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone, Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient


This is RING finger protein unkempt protein, from Fruit fly, contains 599 amino acids, has 5 C3H1-type Zinc finger, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

Essential for late larval/early pupal development


This is NAD(+) hydrolase tir-1 protein, from Caenorhabditis elegans, contains 981 amino acids, is soluble, locates in Cytoplasm.

Regulates expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury


This is Countin-1 protein, from Social amoeba, contains 258 amino acids, is soluble, locates in Extracellular.

Cell-counting factor that limits the maximum size of the multicellular structure, May down-regulate the expression of gp24, which mediates cell adhesion


This is P2X receptor A protein, from Social amoeba, contains 378 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling, Not required for the purinergic response to extracellular nucleotides, Inward currents evoked by intracellular ATP and ATP analogs, Exclusively selective for ATP over other nucleotides, Insensitive to P2 receptor antagonists PPADS, suramin and 2',3'-O-(2,4,6-trinitrophenyl)-ATP but inhibited by nanomolar concentrations of copper and sodium ion, More permeable to ammonium than either sodium or potassium ions and less permeable to choline, It has been reported that p2xA is not essential for osmoregulation (PubMed:19833731), however this information is in contradiction with another source (PubMed:17625565) which indicates that p2xA is required for osmoregulation, Found to be permeable to chloride ions, Inhibited by copper and sodium ions


This is Antimicrobial peptide microplusin protein, from Cattle tick, contains 110 amino acids, is soluble, locates in Extracellular.

Has bacteriostatic activity against the Gram-positive bacterium M,luteus, but not against Gram-negative bacterium E,coli SBS363, Has fungistatic activity against C,neoformans, but not C,albicans, Binds and sequesters copper and iron ions, Copper-chelating is crucial for antimicrobial activity against M,luteus


This is Transmembrane protease serine 11B protein, from Human, contains 416 amino acids, is membrane-bound, locates in Cell membrane.


This is Reticulon-4 receptor-like 2 protein, from Human, contains 420 amino acids, is membrane-bound, locates in Cell membrane.

Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity), Plays a functionally redundant role in postnatal brain development, Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum, Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system, Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity), Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200), Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200)


This is Mitochondrial coenzyme A transporter SLC25A42 protein, from Human, contains 318 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is GPI mannosyltransferase 4 protein, from Human, contains 579 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis, Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly, The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues

Belongs to the glycosyltransferase 22 family, PIGZ subfamily


This is Solute carrier family 22 member 16 protein, from Human, contains 577 amino acids, is membrane-bound, locates in Cell membrane.

High affinity carnitine transporter; the uptake is partially sodium-ion dependent, Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa, Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin, The uptake of TEA is inhibited by various organic cations, The uptake of doxorubicin is sodium-independent

Belongs to the major facilitator (TC 2,A,1) superfamily, Organic cation transporter (TC 2,A,1,19) family


This is CST complex subunit TEN1 protein, from Human, contains 123 amino acids, locates in Nucleus.

Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex, The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves, Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130), However, the CST complex has been shown to be involved in several aspects of telomere replication, The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity, The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445), The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097)


This is Adhesion G protein-coupled receptor G3 protein, from Human, contains 549 amino acids, is membrane-bound, locates in Cell membrane.

Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298), Regulates B-cell development (By similarity), Seems to signal through G-alpha(q)-proteins (PubMed:22575658)

Belongs to the G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily


This is PHD finger protein 13 protein, from Human, contains 300 amino acids, has 1 PHD-type Zinc finger, is soluble, locates in Nucleus.

PHD-type

Modulates chromatin structure, Required for normal chromosome condensation during the early stages of mitosis, Required for normal chromosome separation during mitosis


This is Coiled-coil domain-containing protein 125 protein, from Human, contains 511 amino acids, is soluble, locates in Cytoplasm.

May be involved in the regulation of cell migration


This is Thioredoxin-interacting protein protein, from Mouse, contains 397 amino acids, is soluble, locates in Cytoplasm.

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability, Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm, Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity), Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest, Required for the maturation of natural killer cells, Acts as a suppressor of tumor cell growth


This is Mitochondrial dynamics protein MID51 protein, from Mouse, contains 463 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial outer membrane protein which regulates mitochondrial fission, Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins, Regulates DNM1L GTPase activity and DNM1L oligomerization, Binds ADP and can also bind GDP, although with lower affinity, Does not bind CDP, UDP, ATP, AMP or GTP, Inhibits DNM1L GTPase activity in the absence of bound ADP, Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP, Does not require ADP for its function in recruiting DNM1L


This is Olfactomedin-like protein 2A protein, from Mouse, contains 681 amino acids, is soluble, locates in Extracellular.


This is Actin-binding LIM protein 2 protein, from Mouse, contains 612 amino acids, is soluble, locates in Cytoplasm.

May act as scaffold protein, May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity


This is Phosphatidylserine decarboxylase proenzyme, mitochondrial protein, from Mouse, contains 406 amino acids, locates in Mitochondrion.

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer), Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine, May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity)

Belongs to the phosphatidylserine decarboxylase family, PSD-B subfamily, Eukaryotic type I sub-subfamily


This is Cysteine-rich secretory protein LCCL domain-containing 2 protein, from Mouse, contains 495 amino acids, is soluble, locates in Extracellular.


This is Inhibitor of growth protein 4 protein, from Mouse, contains 249 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4, Through chromatin acetylation it may function in DNA replication, May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation, Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA, May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC, Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity), Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (PubMed:11888890)


This is Telomere repeats-binding bouquet formation protein 1 protein, from Mouse, contains 768 amino acids, is membrane-bound, locates in Nucleus.

Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis (PubMed:24885367, PubMed:24413433, PubMed:26548954), Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex, During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA (PubMed:26548954), In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment' (PubMed:26548954), Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex (PubMed:24885367, PubMed:24413433), Also recruits cohesin to telomeres to develop structural rigidity (PubMed:24413433)


This is Ion channel TACAN protein, from Mouse, contains 343 amino acids, is membrane-bound, locates in Nucleus.

Ion channel involved in sensing mechanical pain (PubMed:32084332), Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli (PubMed:32084332), May also be required for efficient adipogenesis (PubMed:26024229)


This is Meteorin protein, from Mouse, contains 291 amino acids, is soluble, locates in Extracellular.

Involved in both glial cell differentiation and axonal network formation during neurogenesis, Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia, Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia


This is Core histone macro-H2A.2 protein, from Mouse, contains 372 amino acids, locates in Nucleus.

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling, May be involved in stable X chromosome inactivation


This is SPARC-related modular calcium-binding protein 2 protein, from Mouse, contains 447 amino acids, is soluble, locates in Extracellular.

Can stimulate endothelial cell proliferation, migration, as well as angiogenesis (By similarity), Promotes matrix assembly and cell adhesiveness


This is Serine/threonine-protein kinase SIK2 protein, from Mouse, contains 931 amino acids, is soluble, locates in Cytoplasm.

Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:12624099, PubMed:16817901, PubMed:29211348), Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction (PubMed:12624099), Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:16817901), Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity, In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (By similarity), Also plays a role in thymic T-cell development (PubMed:34732767)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily


This is DnaJ homolog subfamily C member 27 protein, from Mouse, contains 273 amino acids, locates in Nucleus.

GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed, May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling

Belongs to the small GTPase superfamily, Rab family


This is Solute carrier family 22 member 12 protein, from Mouse, contains 553 amino acids, is membrane-bound, locates in Cell membrane.

Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:14747372), Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:14747372), Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:14747372), Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (By similarity), Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption, Orotate transport is Cl(-)-dependent (By similarity)


This is Lysine-specific histone demethylase 1B protein, from Mouse, contains 826 amino acids, has 1 CW-type Zinc finger, locates in Nucleus.

CW-type

Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor, Required for de novo DNA methylation of a subset of imprinted genes during oogenesis, Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed, Demethylates both mono- and di-methylated 'Lys-4' of histone H3, Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (PubMed:19407342, PubMed:19727073), Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (By similarity)

Belongs to the flavin monoamine oxidase family


This is Membralin protein, from Mouse, contains 574 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER), Promotes survival of motor neurons, probably by protecting against ER stress


This is Protein DGS1, mitochondrial protein, from Mouse-ear cress, contains 602 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in galactoglycerolipid biosynthesis (PubMed:18208519), Contributes to an intracellular signal that regulates an alternative DGD1-independent galactoglycerolipid biosynthesis pathway in chloroplasts (PubMed:18208519, PubMed:20181751), Being involved in mitochondrial lipid homeostasis, modulates mitochondrion biogenesis and physiology, as well as stress responses (PubMed:31118221)


This is E3 ubiquitin-protein ligase RMA3 protein, from Mouse-ear cress, contains 243 amino acids, has 1 RING-type Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type


This is Enhanced ethylene response protein 5 protein, from Mouse-ear cress, contains 413 amino acids, locates in Nucleus.

Involved in the regulation of ethylene response (PubMed:18429939), Probable TREX-2 component required for nuclear RNA export, The TREX-2 complex (transcription and export complex 2) functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:19843313)


This is WPP domain-interacting protein 1 protein, from Mouse-ear cress, contains 489 amino acids, is membrane-bound, locates in Nucleus.

Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips (PubMed:17600715, PubMed:18591351), As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PubMed:25759303)


This is G patch domain-containing protein TGH protein, from Mouse-ear cress, contains 930 amino acids, is soluble, locates in Nucleus.

Functions as component of microRNA (miRNA) and small interfering RNA (siRNA) biogenesis, May assist DCL1 and DCL4 to efficiently process and/or recruit the precursors of miRNAs and siRNAs, In the miRNA biogenesis pathway, associates with the DCL1 complex that processes primary miRNAs (pri-miRNAs) into miRNAs, Binds pri-miRNAs and precursor miRNAs (pre-miRNAs), Is required for the interaction between pri-miRNAs and DRB1 (PubMed:22802657), Required for general proper plant growth and, in particular, initiation of vascular development, Interacts genetically with AMP1, a glutamate carboxypeptidase involved in the regulation of meristem function (PubMed:16024589)


This is FAD-linked sulfhydryl oxidase ERV1 protein, from Mouse-ear cress, contains 191 amino acids, locates in Mitochondrion.

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation (PubMed:14996837, PubMed:16893552), Oxidizes thioredoxin in vitro (PubMed:14996837, PubMed:16893552), Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space, Forms a redox cycle with MIA40 that involves a disulfide relay system, Important for maintaining the cysteine residues in MIA40 in an oxidized state (By similarity)


This is Nudix hydrolase 15, mitochondrial protein, from Mouse-ear cress, contains 285 amino acids, locates in Mitochondrion.

Coenzyme A diphosphatase which mediates the cleavage of oxidized CoA, Can use malonyl-CoA, hexanoyl-CoA, lauroyl-CoA, myristoyl-CoA and palmitoyl-CoA as substrates, but not isobutyryl-CoA or propionyl-CoA


This is Meiotic nuclear division protein 1 homolog protein, from Mouse-ear cress, contains 230 amino acids, locates in Nucleus.

Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis, Stimulates both DMC1/LIM15- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks


This is Cyclin-dependent kinase inhibitor 4 protein, from Mouse-ear cress, contains 289 amino acids, is soluble, locates in Nucleus.

Binds and inhibits CYCD2-1/CDKA-1 complex kinase activity, May target specifically CDKA-1

Belongs to the CDI family, ICK/KRP subfamily


This is Probable polyamine oxidase 4 protein, from Mouse-ear cress, contains 497 amino acids, locates in Peroxisome.

Flavoenzyme involved in polyamine back-conversion (PubMed:18703589, PubMed:20532512, PubMed:21081665, PubMed:26925084), Catalyzes the oxidation of the secondary amino group of polyamines, such as spermine and spermidine (PubMed:18703589, PubMed:20532512, PubMed:21081665, PubMed:26925084), Substrate preference is spermine > spermidine (PubMed:18703589, PubMed:21081665), No activity detected when putrescine or N(1)-acetylspermine are used as substrates (PubMed:18703589), Plays an important role in the regulation of polyamine intracellular concentration (Probable)


This is Protein Turandot A protein, from Fruit fly, contains 129 amino acids, is soluble, locates in Extracellular.

A humoral factor that plays a role in stress tolerance; gives increased resistance to the lethal effects of bacterial challenge and stress, Regulated by the JAK/STAT pathway and NF-KB-like Relish pathway in the fat body, upd3 in the hemocytes and Mekk1 in response to septic injury and consequent immune response


This is Beta-1,3-glucan-binding protein 2 protein, from Tobacco hawkmoth, contains 482 amino acids, is soluble, locates in Extracellular.

Involved in the recognition of invading microorganisms, Binds specifically to beta-1,3-glucan and lipoteichoic acid and causes aggregation of invading microorganisms, Binding to beta-1,3-glucan activates the phenoloxidase cascade

Belongs to the insect beta-1,3-glucan binding protein family


This is 5'-3' exonuclease PLD3 protein, from Human, contains 490 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (PubMed:30312375), Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity), May be important in myotube formation (PubMed:22428023), Plays a role in lysosomal homeostasis (PubMed:28128235), Involved in the regulation of endosomal protein sorting (PubMed:29368044)


This is Organic anion transporter 7 protein, from Human, contains 553 amino acids, is membrane-bound, locates in Cell membrane.

Sodium-independent organic anion transporter, exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) (PubMed:17393504, PubMed:26239079), Can transport the statin pravastatin and may contribute to its disposition into the hepatocytes when the function of OATPs is compromised (PubMed:26239079), It is specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate (propanoate), butyrate (butanoate) and valerate (pentanoate) (PubMed:17393504), May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs, in particular butanoate, at the sinusoidal membrane of hepatocytes (PubMed:17393504)


This is FUN14 domain-containing protein 1 protein, from Human, contains 155 amino acids, is membrane-bound, locates in Mitochondrion.

Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control


This is Centrosomal protein of 97 kDa protein, from Human, contains 865 amino acids, is soluble, locates in Cytoplasm.

Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385), Required for recruitment of CCP110 to the centrosome (PubMed:17719545)


This is MAP7 domain-containing protein 3 protein, from Human, contains 876 amino acids, is soluble, locates in Cytoplasm.

Promotes the assembly and stability of microtubules


This is FAD-dependent oxidoreductase domain-containing protein 2 protein, from Human, contains 684 amino acids, is soluble, locates in Endoplasmic reticulum.

Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD), May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation


This is Sphingosine-1-phosphate phosphatase 2 protein, from Human, contains 399 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Has specific phosphohydrolase activity towards sphingoid base 1-phosphates, Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (PubMed:12411432), Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity), May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling, May play a role in pro-inflammatory signaling (PubMed:17113265), Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity)

Belongs to the type 2 lipid phosphate phosphatase family


This is Monocyte to macrophage differentiation factor 2 protein, from Human, contains 270 amino acids, is membrane-bound, locates in Golgi apparatus.


This is E3 ubiquitin-protein ligase RNF168 protein, from Human, contains 571 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage, Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination, Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates, This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1, Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair, H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates, Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair, Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites, Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region, Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)


This is Coiled-coil domain-containing protein 116 protein, from Human, contains 613 amino acids, is soluble, locates in Cytoplasm.


This is Cilium assembly protein DZIP1L protein, from Human, contains 767 amino acids, has 1 C2H2-type Zinc finger, is soluble, locates in Cytoplasm.

Involved in primary cilium formation (PubMed:19852954, PubMed:28530676), Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane (PubMed:28530676)

Belongs to the DZIP C2H2-type zinc-finger protein family


This is Netrin receptor UNC5B protein, from Human, contains 945 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance, Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding, Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity), Functions as netrin receptor that negatively regulates vascular branching during angiogenesis, Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity), It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906), Mediates apoptosis by activating DAPK1, In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity)


This is Protein FAM9B protein, from Human, contains 186 amino acids, locates in Nucleus.


This is Protein APCDD1 protein, from Human, contains 514 amino acids, is membrane-bound, locates in Cell membrane.

Negative regulator of the Wnt signaling pathway, Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin, May act via its interaction with Wnt and LRP proteins, May play a role in colorectal tumorigenesis


This is Zinc finger protein 467 protein, from Mouse, contains 594 amino acids, has 12 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow, Enhances the osteoclast-supporting ability of stromal cells, Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE), Transactivates several promoters including FOS, OSM and PPARG, Recruits a histone deacetylase complex

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Katanin p60 ATPase-containing subunit A-like 1 protein, from Mouse, contains 488 amino acids, is soluble, locates in Cytoplasm.

Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility, Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (PubMed:22654668), Has microtubule-severing activity in vitro (By similarity)

Belongs to the AAA ATPase family, Katanin p60 subunit A1 subfamily, A-like 1 sub-subfamily


This is Zinc finger protein GLIS1 protein, from Mouse, contains 789 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, locates in Nucleus.

C2H2-type 2; atypical

Acts as both a repressor and activator of transcription (PubMed:12042312, PubMed:12385751, PubMed:21654807), Binds to the consensus sequence 5'-GACCACCCAC-3' (PubMed:12042312), By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807, PubMed:30544251), Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (PubMed:30544251)

Belongs to the GLI C2H2-type zinc-finger protein family


This is Netrin receptor UNC5D protein, from Mouse, contains 956 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Ig-like C2-type

Receptor for the netrin NTN4 that promotes neuronal cell survival (PubMed:21216843), Plays a role in cell-cell adhesion and cell guidance, Receptor for netrin involved in cell migration (By similarity), Plays a role in the regulation of neuronal cell migration in the developing brain via its interaction with FLRT2 (PubMed:21673655), Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:21673655), May play a role in apoptosis in response to DNA damage, It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity), Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (PubMed:26235030)


This is Netrin receptor UNC5B protein, from Mouse, contains 945 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance, Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding, Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity), Functions as netrin receptor that negatively regulates vascular branching during angiogenesis (PubMed:15510105), Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (PubMed:15510105), It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand, Mediates apoptosis by activating DAPK1, In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity)


This is Transmembrane protease serine 3 protein, from Mouse, contains 453 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Probable serine protease that plays a role in hearing, Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival, Activates ENaC (in vitro)


This is Endonuclease 8-like 3 protein, from Mouse, contains 606 amino acids, has 1 FPG-type Zinc finger, has 1 RanBP2-type Zinc finger, has 2 GRF-type Zinc finger, locates in Nucleus.

FPG-type

GRF-type

GRF-type

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161), Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity), In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161), No activity on 8-oxoG detected (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161), Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161), In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161)


This is Mitochondrial adenyl nucleotide antiporter SLC25A25 protein, from Rat, contains 469 amino acids, is membrane-bound, locates in Mitochondrion.

Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane, Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it could have a broader specificity for adenyl nucleotides, By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways


This is Forkhead box protein N4 protein, from Mouse, contains 521 amino acids, locates in Nucleus.

Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively, Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3', During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling, Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis, In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development


This is Actin-binding LIM protein 1 protein, from Mouse, contains 861 amino acids, is soluble, locates in Cytoplasm.

May act as scaffold protein (By similarity), May play a role in the development of the retina, Has been suggested to play a role in axon guidance


This is E3 ubiquitin-protein ligase CBL-B protein, from Rat, contains 938 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome, Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways, In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production, Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation, In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy, In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation, Slightly promotes SRC ubiquitination, May be involved in EGFR ubiquitination and internalization, May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3, In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity)


This is G-protein coupled receptor family C group 6 member A protein, from Mouse, contains 928 amino acids, is membrane-bound, locates in Cell membrane.

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids, The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+), Activated by extracellular calcium and osteocalcin, Seems to act through a G(q)/G(11) and G(i)-coupled pathway, Mediates the non-genomic effects of androgens in multiple tissue, May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids

Belongs to the G-protein coupled receptor 3 family


This is Sodium/calcium exchanger 2 protein, from Mouse, contains 921 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:12818181), Contributes to cellular Ca(2+) homeostasis in excitable cells (PubMed:12818181), Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (PubMed:12818181), Plays a role in regulating urinary Ca(2+) and Na(+) excretion (PubMed:25498502)

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2,A,19) family, SLC8 subfamily


This is Transcription factor PIL1 protein, from Mouse-ear cress, contains 416 amino acids, locates in Nucleus.

Transcription factor, Involved in responses to transient and long-term shade, Required for the light-mediated inhibition of hypocotyl elongation, Necessary for rapid light-induced expression of the photomorphogenesis- and circadian-related gene APRR9, Seems to play a role in multiple PHYB responses, such as flowering transition and petiole elongation


This is Short integuments 2, mitochondrial protein, from Mouse-ear cress, contains 386 amino acids, locates in Mitochondrion.

GTPase that may function in mitochondrial ribosome assembly (Probable), Involved in a variety of growth processes during vegetative development and promotes growth and cell division in the developing integuments (PubMed:10835408, PubMed:16849600)

Belongs to the TRAFAC class YlqF/YawG GTPase family, MTG1 subfamily


This is Nuclear pore complex protein NUP62 protein, from Mouse-ear cress, contains 739 amino acids, locates in Nucleus.

Belongs to the nucleoporin NSP1/NUP62 family


This is UDP-glycosyltransferase TURAN protein, from Mouse-ear cress, contains 465 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for pollen tube (PT) growth and integrity by affecting the stability of the pollen-specific ANX1 and ANX2 proteins, Involved in protein N-glycosylation in the endoplasmic reticulum (ER), especially in the female gametophyte, Mediates PT reception in synergids through protein glycosylation

Belongs to the glycosyltransferase group 1 family, Glycosyltransferase 33 subfamily


This is Alpha-L-fucosidase 2 protein, from Mouse-ear cress, contains 843 amino acids, is soluble, locates in Extracellular.

Hydrolyzes alpha-1,2-linked fucose, Also active on fucosylated xyloglucan oligosaccharides, No activity with 3-fucosyllactose, p-nitrophenyl-alpha-I-fucopyranoside, lacto-N-fucopentaose II, lacto-N-fucopentaose III or alpha 1,6-fucosylated chitopentaose, Involved in apoplastic xyloglucan metabolism

Belongs to the glycosyl hydrolase 95 family


This is Transmembrane ascorbate ferrireductase 1 protein, from Mouse-ear cress, contains 239 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Two-heme-containing cytochrome, Catalyzes ascorbate-dependent trans-membrane ferric-chelate reduction, Able to use dihydrolipoic acid (DHLA) as an alternative substrate to ascorbate


This is Large ribosomal subunit protein bL21m protein, from Mouse-ear cress, contains 270 amino acids, locates in Mitochondrion.

This protein binds to 23S ribosomal RNA in the presence of protein L20 (By similarity), Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus, and during double fertilization of the egg cell and the central cell (PubMed:16698901)

Belongs to the bacterial ribosomal protein bL21 family


This is ATP-dependent Clp protease proteolytic subunit-related protein 4, chloroplastic protein, from Mouse-ear cress, contains 305 amino acids, locates in Plastid.


This is Inner membrane protein ALBINO3, chloroplastic protein, from Mouse-ear cress, contains 462 amino acids, is membrane-bound, locates in Plastid.

Required for the insertion of some light harvesting chlorophyll-binding proteins (LHCP) into the chloroplast thylakoid membrane, Required for the insertion of LHCB1, LHCB4,1 and LHCB5 proteins into thylakoid membrane, while it is not required for insertion of proteins PsbX, PsbW and PsbY

Belongs to the OXA1/ALB3/YidC (TC 2,A,9,2) family


This is Mitochondrial pyruvate carrier 3 protein, from Mouse-ear cress, contains 108 amino acids, is membrane-bound, locates in Mitochondrion.

Mediates the uptake of pyruvate into mitochondria, Negatively regulates ABA-induced guard cell signaling and mediates drought stress responses

Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2,A,105) family


This is High mobility group B protein 7 protein, from Mouse-ear cress, contains 241 amino acids, locates in Nucleus.

Binds preferentially double-stranded supercoiled DNA (PubMed:14756567), Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus (PubMed:16698901)


This is Protein HHL1, chloroplastic protein, from Mouse-ear cress, contains 231 amino acids, is membrane-bound, locates in Plastid.

Involved in photoprotection, Forms a complex with LQY1 that is involved in the repair and reassembly cycle of the PSII-LHCII supercomplex under high-light conditions, May function in guiding the release of psbC from PSII core monomers


This is Glutathione S-transferase DHAR3, chloroplastic protein, from Mouse-ear cress, contains 258 amino acids, is soluble, locates in Plastid.

Displays a dual function, As a soluble protein, exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities (PubMed:12077129), Key component of the ascorbate recycling system, Involved in the redox homeostasis, especially in scavenging of ROS under oxidative stresses (By similarity)

Belongs to the GST superfamily, DHAR family


This is 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 protein, from Mouse-ear cress, contains 389 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position, Has preference for C-18-CoA substrates compared to C-16-CoA substrates, Required for female but not male gametophyte development

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


This is Cell division cycle protein 27 homolog B protein, from Mouse-ear cress, contains 744 amino acids, locates in Nucleus.

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle, The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins, The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation, Involved in the control of endoreduplication, Functionally redundant with CDC27A in the control of gametophyte development


This is NADP-dependent glyceraldehyde-3-phosphate dehydrogenase protein, from Wheat, contains 496 amino acids, is soluble, locates in Cytoplasm.

Important as a means of generating NADPH for biosynthetic reactions

Belongs to the aldehyde dehydrogenase family


This is Flowering time control protein FPA protein, from Mouse-ear cress, contains 901 amino acids, locates in Nucleus.

Plays a role in the regulation of flowering time in the autonomous flowering pathway by decreasing FLOWERING LOCUS C mRNA levels, Required for RNA-mediated chromatin silencing of a range of loci in the genome, Cotranscriptionally recognizes aberrant RNA and marks it for silencing, Controls alternative cleavage and polyadenylation on pre-mRNAs and antisense RNAs, Acts redundantly with FCA to prevent the expression of distally polyadenylated antisense RNAs at the FLC locus


This is cGMP-dependent 3',5'-cGMP phosphodiesterase A protein, from Social amoeba, contains 867 amino acids, is soluble, locates in Cytoplasm.

Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP (PubMed:12429832, PubMed:12429831) (Probable), Involved in the degradation of intracellular cGMP, contributes to the control of cGMP signals (PubMed:12198158, PubMed:12429832)

Belongs to the metallo-beta-lactamase superfamily, cNMP phosphodiesterase family


This is Homeodomain-interacting protein kinase 1 protein, from Caenorhabditis elegans, contains 846 amino acids, locates in Nucleus.

Serine/threonine-protein kinase required in the somatic gonadal cells to regulate germline proliferation during larval development and in adulthood (PubMed:23904186), Plays a role in the development/differentiation of gonadal distal tip cells (PubMed:23904186), Required for normal lifespan in a pha-4 and mxl-2-dependent manner (PubMed:26791749, PubMed:29036198, PubMed:36173858), Also contributes to survival following heat or oxidative stress (PubMed:26791749), Prevents sumoylation and inactivation of heat shock transcription factor hsf-1 which enhances hsf-1-dependent transcriptional induction of chaperones in response to heat shock (PubMed:29036198), Also required for hormetic extension of longevity in response to heat stress (PubMed:29036198), Provides protection against polyglutamine aggregate formation and associated locomotory toxicity (PubMed:29036198), Also contributes to longevity by promoting autophagy under nutrient stress conditions through induction of autophagosome formation and autophagy gene expression (PubMed:29036198)

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, HIPK subfamily


This is Beta-1,3-glucan-binding protein protein, from Indianmeal moth, contains 488 amino acids, is soluble, locates in Extracellular.

Involved in the recognition of invading microorganisms causing their aggregation (PubMed:12770576, PubMed:15084591), Activates the phenoloxidase cascade (PubMed:12770576, PubMed:15084591, PubMed:23237493), Binds specifically to beta-1,3-glucan (PubMed:12770576, PubMed:15084591, PubMed:21697086, PubMed:23237493), Binds to curdlan, a linear water-insoluble beta-1,3-glucan polysaccharide, and to laminarin, a water-soluble beta-1,3-glucan polysaccharide containing beta-1,6 branches (PubMed:15084591, PubMed:21697086, PubMed:23237493), Binds also to lipopolysaccharide and lipoteichoic acid (PubMed:15084591)

Belongs to the insect beta-1,3-glucan binding protein family


This is Acyl-coenzyme A thioesterase THEM5 protein, from Human, contains 247 amino acids, is soluble, locates in Mitochondrion.

Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (PubMed:22586271), Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271), Required for normal mitochondrial function (PubMed:22586271)

Belongs to the THEM4/THEM5 thioesterase family


This is Mitochondrial cardiolipin hydrolase protein, from Human, contains 252 amino acids, has 1 C3H1-type; atypical Zinc finger, is membrane-bound, locates in Mitochondrion.

C3H1-type; atypical

Presents phospholipase and nuclease activities, depending on the different physiological conditions (PubMed:17028579, PubMed:21397847, PubMed:28063496), Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity (PubMed:26711011), Plays a key role in mitochondrial fusion and fission via its phospholipase activity (PubMed:17028579, PubMed:24599962, PubMed:26678338), In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid (PubMed:17028579, PubMed:26711011), Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission (PubMed:24599962), Both Lipin and DAG regulate mitochondrial dynamics and membrane fusion/fission, important processes for adapting mitochondrial metabolism to changes in cell physiology, Mitochondrial fusion enables cells to cope with the increased nucleotide demand during DNA synthesis (PubMed:26678338), Mitochondrial function and dynamics are closely associated with biological processes such as cell growth, proliferation, and differentiation (PubMed:21397848), Mediator of MYC activity, promotes mitochondrial fusion and activates AMPK which in turn inhibits YAP/TAZ, thereby inducing cell growth and proliferation (PubMed:26678338), The endonuclease activity plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis (PubMed:21397847, PubMed:21397848), Implicated in spermatogenesis and sperm fertility in testicular germ cells, its single strand-specific nuclease activity is critical for the biogenesis/maturation of PIWI-interacting RNA (piRNA), MOV10L1 selectively binds to piRNA precursors and funnels them to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins, Cleaves either DNA or RNA substrates with similar affinity, producing a 5' phosphate end, in this way it participates in the processing of primary piRNA transcripts, piRNAs provide essential protection against the activity of mobile genetic elements, piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity), PA may act as signaling molecule in the recognition/transport of the precursor RNAs of primary piRNAs (PubMed:21397847), Interacts with tesmin in testes, suggesting a role in spermatogenesis via association with its interacting partner (By similarity)

Belongs to the phospholipase D family, MitoPLD/Zucchini subfamily


This is Armadillo repeat-containing protein 10 protein, from Human, contains 343 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May play a role in cell survival and cell growth, May suppress the transcriptional activity of p53/TP53


This is Centromere protein S protein, from Human, contains 138 amino acids, locates in Nucleus.

DNA-binding component of the Fanconi anemia (FA) core complex, Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429), In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA, Stabilizes FANCM (PubMed:20347428, PubMed:20347429), In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428), In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631), As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:22304917), DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded, Does not bind DNA on its own (PubMed:20347428, PubMed:20347429)

Belongs to the TAF9 family, CENP-S/MHF1 subfamily


This is Transmembrane protein 130 protein, from Human, contains 435 amino acids, is membrane-bound, locates in Golgi apparatus.


This is Thioredoxin domain-containing protein 3 protein, from Human, contains 588 amino acids, is soluble, locates in Cytoplasm.

Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs, May be involved in the reduction of disulfide bonds within the sperm FS components, In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds

In the C-terminal section; belongs to the NDK family


This is Carboxypeptidase A6 protein, from Human, contains 437 amino acids, is soluble, locates in Extracellular.

May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas, May convert inactive angiotensin I into the biologically active angiotensin II (PubMed:18178555), Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine (PubMed:20855895)


This is Actin filament-associated protein 1-like 2 protein, from Human, contains 818 amino acids, is soluble, locates in Cytoplasm.

May play a role in a signaling cascade by enhancing the kinase activity of SRC, Contributes to SRC-regulated transcription activation


This is Actin filament-associated protein 1 protein, from Human, contains 730 amino acids, is soluble, locates in Cytoplasm.

Can cross-link actin filaments into both network and bundle structures (By similarity), May modulate changes in actin filament integrity and induce lamellipodia formation, May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton, Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells


This is Oxidation resistance protein 1 protein, from Human, contains 874 amino acids, locates in Mitochondrion.

May be involved in protection from oxidative damage


This is Protein jagunal homolog 1 protein, from Human, contains 183 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function, Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport, Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils


This is BTB/POZ domain-containing protein KCTD17 protein, from Human, contains 321 amino acids, is soluble, locates in Cytoplasm.

Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension, It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598), May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243)


This is Sodium-coupled monocarboxylate transporter 1 protein, from Human, contains 610 amino acids, is membrane-bound, locates in Cell membrane.

Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 (PubMed:14966140, PubMed:15090606, PubMed:17178845, PubMed:16805814, PubMed:16729224, PubMed:17526579, PubMed:17245649, PubMed:20211600, PubMed:30604288), Catalyzes passive carrier mediated diffusion of iodide (PubMed:12107270), Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (PubMed:12107270), May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract (PubMed:17245649), Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines (PubMed:12829793, PubMed:15867356, PubMed:18037591), May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons (PubMed:16805814), Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) (PubMed:20211600), Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced (PubMed:19864324)

Belongs to the sodium:solute symporter (SSF) (TC 2,A,21) family


This is Ankyrin repeat domain-containing protein 13C protein, from Human, contains 541 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER


This is RNA polymerase II-associated factor 1 homolog protein, from Human, contains 531 amino acids, locates in Nucleus.

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency, PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1, PAF1C is required for transcription of Hox and Wnt target genes, PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL, PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3), PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription, PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors, In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription, Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex, Involved in polyadenylation of mRNA precursors, Has oncogenic activity in vivo and in vitro


This is APC membrane recruitment protein 2 protein, from Human, contains 671 amino acids, is membrane-bound, locates in Cell membrane.

Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning, Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex


This is E3 ubiquitin-protein ligase RNF152 protein, from Human, contains 203 amino acids, has 1 RING-type Zinc finger, is membrane-bound, locates in Lysosome/Vacuole.

RING-type

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation, Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802), Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation, Induces apoptosis when overexpressed (PubMed:21203937)


This is Cytochrome c oxidase assembly protein COX18, mitochondrial protein, from Human, contains 333 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane, Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2, Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase)


This is Large ribosomal subunit protein mL43 protein, from Human, contains 215 amino acids, locates in Mitochondrion.

Belongs to the mitochondrion-specific ribosomal protein mL43 family


This is Probable RNA-binding protein EIF1AD protein, from Human, contains 165 amino acids, locates in Nucleus.

Plays a role into cellular response to oxidative stress, Decreases cell proliferation


This is Protein boule-like protein, from Human, contains 283 amino acids, is soluble, locates in Cytoplasm.

Probable RNA-binding protein, which may be required during spermatogenesis, May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity)


This is Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 protein, from Human, contains 580 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein, Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity

Belongs to the glycosyltransferase 61 family


This is Xyloside xylosyltransferase 1 protein, from Human, contains 393 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869), Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869)

Belongs to the glycosyltransferase 8 family


This is Myotubularin-related protein 14 protein, from Human, contains 650 amino acids, is soluble, locates in Cytoplasm.

Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3

Belongs to the protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily


This is Putative RNA-binding protein 15B protein, from Human, contains 890 amino acids, is soluble, locates in Nucleus.

RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518), Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518), Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518), Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518), Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689), Inhibits pre-mRNA splicing (PubMed:21044963), Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903)


This is Polyhomeotic-like protein 3 protein, from Human, contains 983 amino acids, has 1 FCS-type Zinc finger, locates in Nucleus.

FCS-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility


This is Zinc transporter 7 protein, from Human, contains 376 amino acids, is membrane-bound, locates in Golgi apparatus.

Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed:15525635, PubMed:15994300), By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (PubMed:15525635, PubMed:15994300)

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2,A,4) family, SLC30A subfamily


This is Zinc finger MIZ domain-containing protein 2 protein, from Human, contains 920 amino acids, has 1 SP-RING-type Zinc finger, locates in Nucleus.

SP-RING-type

Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors


This is Prokineticin receptor 2 protein, from Human, contains 384 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for prokineticin 2, Exclusively coupled to the G(q) subclass of heteromeric G proteins, Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase

Belongs to the G-protein coupled receptor 1 family


This is N-acylneuraminate cytidylyltransferase protein, from Human, contains 434 amino acids, locates in Nucleus.

Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid, Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)

Belongs to the CMP-NeuNAc synthase family


This is Leukocyte immunoglobulin-like receptor subfamily B member 4 protein, from Human, contains 448 amino acids, has 2 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462), Receptor for FN1 (PubMed:34089617), Receptor for apolipoprotein APOE (PubMed:30333625), Receptor for ALCAM/CD166 (PubMed:29263213), Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699), Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736), This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617), Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213), Induces up-regulation of CD86 on dendritic cells (PubMed:19860908), Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462)


This is Major facilitator superfamily domain-containing protein 8 protein, from Human, contains 518 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

May be a carrier that transport small solutes by using chemiosmotic ion gradients

Belongs to the major facilitator superfamily


This is CLOCK-interacting pacemaker protein, from Mouse, contains 432 amino acids, locates in Nucleus.

Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism, May stimulate BMAL1-dependent phosphorylation of CLOCK (PubMed:17310242, PubMed:19414601), However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock (PubMed:25862660)


This is Monoacylglycerol lipase ABHD6 protein, from Mouse, contains 336 amino acids, is membrane-bound, locates in Mitochondrion.

Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:18096503, PubMed:20657592), Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (PubMed:18096503, PubMed:20657592), Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (PubMed:24095738), Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015), BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015)


This is von Willebrand factor A domain-containing protein 1 protein, from Mouse, contains 415 amino acids, is soluble, locates in Extracellular.

Promotes matrix assembly (PubMed:18757743), Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions (By similarity)


This is Immunoglobulin superfamily member 8 protein, from Mouse, contains 611 amino acids, has 4 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function, May regulate proliferation and differentiation of keratinocytes, May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers, May also play a role on integrin-dependent morphology and motility functions, May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain


This is Heparan sulfate 2-O-sulfotransferase 1 protein, from Mouse, contains 356 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS), 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes, Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme, Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues

Belongs to the sulfotransferase 3 family


This is Ribitol-5-phosphate transferase FKTN protein, from Mouse, contains 461 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the transfer of CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:12471058), This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (By similarity), Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity (PubMed:19017726), May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes (PubMed:19017726, PubMed:22922256), Could be involved in brain development (Probable)


This is Transketolase-1, chloroplastic protein, from Mouse-ear cress, contains 741 amino acids, is membrane-bound, locates in Plastid.

Catalyzes the reversible transfer of a two-carbon ketol group from fructose-6-phosphate or sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to yield xylulose-5-phosphate and erythrose-4-phosphate or ribose-5-phosphate, respectively (By similarity), Could act as a stress sensor involved in adaptation process


This is Cyclin-L1-1 protein, from Mouse-ear cress, contains 416 amino acids, locates in Nucleus.

Cognate cyclin for CDKG1, Required for synapsis and male meiosis, and for the proper splicing of specific resistance (R) genes, Involved in regulation of DNA methylation and transcriptional silencing

Belongs to the cyclin family, Cyclin L subfamily


This is CAAX prenyl protease 1 homolog protein, from Mouse-ear cress, contains 424 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Proteolytically removes the C-terminal three residues of farnesylated proteins, The substrate specificity is only partially overlapping with that of FACE2


This is ABC transporter G family member 11 protein, from Mouse-ear cress, contains 703 amino acids, is membrane-bound, locates in Cell membrane.

Required for the cuticle, root suberin and pollen coat development by controlling cutin and maybe wax transport to the extracellular matrix (PubMed:24112720, PubMed:20035035), Involved in developmental plasticity and stress responses, Together with ABCG9 and ABCG14, required for vascular development by regulating lipid/sterol homeostasis (PubMed:24112720), May be a transporter of lignin precursors during tracheary element differentiation (PubMed:28921082)

Belongs to the ABC transporter superfamily, ABCG family, Eye pigment precursor importer (TC 3,A,1,204) subfamily


This is Phospholipase A1 EG1, chloroplastic/mitochondrial protein, from Rice, contains 435 amino acids, locates in Plastid.

Phospholipase that releases free fatty acids from phospholipids, Catalyzes the initial step of jasmonate (JA) biosynthesis, Required for the biosynthesis of endogenous JA in seedling, inflorescence and spikelets, Not essential for JA biosynthesis after wounding (PubMed:24647160), Mediates spikelet development and specification of empty-glume identity (PubMed:18980657, PubMed:24647160), Functions in a high temperature-dependent manner to maintain floral developmental robustness under heat stress conditions, Functions by safeguarding the expression of several floral identity genes, such as MADS1, MADS6 and G1 (PubMed:27367609)

Belongs to the AB hydrolase superfamily, Lipase family


This is Sulfoquinovosyl transferase SQD2 protein, from Mouse-ear cress, contains 510 amino acids, is membrane-bound, locates in Plastid.

Catalyzes the transfer of the sulfoquinovose moiety from UDP-sulfoquinovose to diacylglycerol during sulfolipid biosynthesis (PubMed:11960029), Sulfolipid contributes to maintaining a negatively charged lipid-water interface, a requirement for proper function of photosynthetic membranes (PubMed:11960029), Sulfolipid may also function as a substitute of anionic phospholipids under phosphate-limited growth conditions (PubMed:11960029)

Belongs to the glycosyltransferase group 1 family, Glycosyltransferase 4 subfamily


This is Probable WRKY transcription factor 33 protein, from Mouse-ear cress, contains 519 amino acids, locates in Nucleus.

Transcription factor, Interacts specifically with the W box (5'-TTGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element, Involved in defense responses, Required for resistance to the necrotrophic fungal pathogen B,cinerea (PubMed:17059405, PubMed:21990940), Regulates the antagonistic relationship between defense pathways mediating responses to the bacterial pathogen P, syringae and the necrotrophic pathogen B,cinerea (PubMed:17059405), Required for the phytoalexin camalexin synthesis following infection with B,cinerea, Acts as positive regulator of the camalexin biosynthetic genes PAD3 (CYP71B15) and CYP71A13 by binding to their promoters (PubMed:21498677, PubMed:22392279), Acts downstream of MPK3 and MPK6 in reprogramming the expression of camalexin biosynthetic genes, which drives the metabolic flow to camalexin production (PubMed:21498677), Functions with WRKY25 as positive regulator of salt stress response and abscisic acid (ABA) signaling (PubMed:18839316), Functions with WRKY25 and WRKY26 as positive regulator of plant thermotolerance by partially participating in ethylene-response signal transduction pathway (PubMed:21336597), The DNA-binding activity of WRKY33 is increased by SIB1 and SIB2 (PubMed:21990940)


This is Poly(U)-binding-splicing factor half pint protein, from Fruit fly, contains 637 amino acids, locates in Nucleus.

Splicing factor that regulates oogenesis and controls both mitosis and mRNA localization in the germline by regulating mRNA splicing of a subset of genes within the ovary, Probably acts by regulating the alternative splice site selection of the otu transcript, Also regulates the alternative splicing of eIF4E1 and grk, while it is not involved in the splicing of par-1, sqd and psq


This is Proton-coupled zinc antiporter SLC30A5 protein, from Human, contains 765 amino acids, is membrane-bound, locates in Golgi apparatus.

Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane


This is Endonuclease 8-like 3 protein, from Human, contains 605 amino acids, has 1 FPG-type Zinc finger, has 1 RanBP2-type Zinc finger, has 2 GRF-type Zinc finger, locates in Nucleus.

FPG-type

GRF-type

GRF-type

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964), Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity), In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964), No activity on 8-oxoG detected (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964), Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964), In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964)


This is N-lysine methyltransferase SETD6 protein, from Human, contains 473 amino acids, locates in Nucleus.

Protein-lysine N-methyltransferase, Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity (PubMed:21131967, PubMed:30189201, PubMed:21515635), Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626), Required for the maintenance of embryonic stem cell self-renewal (By similarity), Methylates PAK4

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SETD6 subfamily


This is T-complex protein 10A homolog 1 protein, from Human, contains 215 amino acids, locates in Nucleus.

May be involved in transcriptional regulation, Has in vitro transcription inhibition activity, Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells


This is Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 protein, from Human, contains 903 amino acids, has 1 C4-type Zinc finger, is soluble, locates in Cytoplasm.


This is Guanosine-diphosphatase protein, from Yeast, contains 599 amino acids, is membrane-bound, locates in Golgi apparatus.

Has a role in cell wall morphogenesis during the transition of budding growth into hyphal growth, a process known as dimorphism


This is Olfactory receptor 51E2 protein, from Mouse, contains 320 amino acids, is membrane-bound, locates in Cell membrane.

Olfactory receptor, The activity of this receptor is probably mediated by G-proteins wich induce elevation of intracellular Ca(2+), cAMP and activation of phosphorylation of the protein kinases PKA and MAPK3/MAPK1, Activation of OR51E2 may affect melanocyte proliferation, differentiation, and melanogenesis and may increase proliferation and migration of primary retinal pigment epithelial (RPE) cells (By similarity), Activated by the short chain fatty acids (SCFA), acetate and propionate (PubMed:23401498), In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498), May also be activated by steroid hormones and regulate cell proliferation (By similarity), Activated by L-lactate in glomus cells (PubMed:26560302, PubMed:30258151)


This is Solute carrier family 22 member 6 protein, from Mouse, contains 545 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the renal elimination of endogenous and exogenous organic anions, Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc), Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (By similarity), May contribute to the transport of organic compounds in testes across the blood-testis-barrier (By similarity), Also mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate (By similarity), Mediates the sodium-independent uptake of p-aminohippurate (PAH), PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate (By similarity), PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid and PKC activators

Belongs to the major facilitator (TC 2,A,1) superfamily, Organic cation transporter (TC 2,A,1,19) family


This is Ubiquitin-conjugating enzyme E2 W protein, from Mouse, contains 151 amino acids, locates in Nucleus.

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins, Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini (PubMed:21855799, PubMed:21229326), Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3 (PubMed:21855799), After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:21229326), In vitro catalyzes 'Lys-11'-linked polyubiquitination, UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i,e, lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate (By similarity)

Belongs to the ubiquitin-conjugating enzyme family


This is Meteorin-like protein protein, from Mouse, contains 311 amino acids, is soluble, locates in Extracellular.

Hormone induced following exercise or cold exposure that promotes energy expenditure, Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation, Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance, Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions, Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat, Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures


This is Placenta-expressed transcript 1 protein protein, from Mouse, contains 237 amino acids, is membrane-bound, locates in Cell membrane.

Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair, May play a role during trichilemmal differentiation of the hair follicle


This is Single-stranded DNA-binding protein WHY2, mitochondrial protein, from Mouse-ear cress, contains 238 amino acids, locates in Mitochondrion.

Single-stranded DNA-binding protein that associates with mitochondrial DNA and may play a role in the regulation of the gene expression machinery, Seems also to be required to prevent break-induced DNA rearrangements in the mitochondrial genome, Can bind to melt double-stranded DNA in vivo


This is Trihelix transcription factor ASR3 protein, from Mouse-ear cress, contains 314 amino acids, locates in Nucleus.

Transcriptional repressor that binds DNA and plays a negative role in regulating microbe-associated molecular patterns-(MAMPs, e,g, flg22, elf18, chitin, and LPS) triggered immunity (PTI) by negatively regulating immune gene expression


This is Transcription factor PIF4 protein, from Mouse-ear cress, contains 430 amino acids, locates in Nucleus.

Transcription factor acting negatively in the phytochrome B signaling pathway, May regulate the expression of a subset of genes involved in cell expansion by binding to the G-box motif (By similarity), Activated by CRY1 and CRY2 in response to low blue light (LBL) by direct binding at chromatin on E-box variant 5'-CA[CT]GTG-3' to stimulate specific gene expression to adapt global physiology (e,g, hypocotyl elongation in low blue light) (PubMed:26724867)


This is Peptidyl-prolyl cis-trans isomerase CYP71 protein, from Mouse-ear cress, contains 631 amino acids, locates in Nucleus.

PPIases accelerate the folding of proteins (Probable), It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:33098102), Histone proline isomerase that increases the rate of cis-trans isomerization of the synthetic histone H3 peptides H3P30 (RKSAP30F-p-nitroanilide) and H3P30K27me3 (RKme3-SAP30F-p-nitroanilide) in the histone H3 N-terminal tail, in vitro (PubMed:33098102), Histone remodeling factor involved in chromatin-based gene silencing (PubMed:17704213), Reinforces H3K27 methylation (PubMed:17704213), Involved in fundamental processes of chromatin assembly and histone modification by mediating the targeting of FAS1 and LHP1 on the chromatin (PubMed:21596687), Required for the formation and development of leaves, for normal phyllotaxy and for the formation, maintenance and activity of root and shoot apical meristems (PubMed:17704213)

Belongs to the cyclophilin-type PPIase family


This is FHA domain-containing protein DDL protein, from Mouse-ear cress, contains 314 amino acids, locates in Nucleus.

Involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis, May facilitate DCL1 to access or recognize primary miRNAs, Binds RNA non-specifically