This is 4-O-methyl-glucuronoyl methylesterase protein, from Canker rot fungus, contains 474 amino acids, is soluble, locates in Extracellular.

Glucuronoyl esterase which may play a significant role in biomass degradation, as it is considered to disconnect hemicellulose from lignin through the hydrolysis of the ester bond between 4-O-methyl-D-glucuronic acid residues of glucuronoxylans and aromatic alcohols of lignin (PubMed:25425346, PubMed:26712478)

Belongs to the carbohydrate esterase 15 (CE15) family


This is E3 ubiquitin-protein ligase TM129 protein, from Human, contains 362 amino acids, has 1 RING-type; degenerate Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type; degenerate

E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2, Exploited by viral US11 proteins to mediate HLA class I proteins degradation


This is Transcription factor E2F8 protein, from Human, contains 867 amino acids, locates in Nucleus.

Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells, Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3', Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis, Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3), Required for placental development by promoting polyploidization of trophoblast giant cells, Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene


This is Fez family zinc finger protein 1 protein, from Human, contains 475 amino acids, has 6 C2H2-type Zinc finger, locates in Nucleus.

Transcription repressor, Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN), Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation, Expression is required in OSN to cell-autonomously regulate OSN axon projections, Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons, May be required for correct rostral migration of the interneuron progenitors (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is CASP-like protein PIMP1 protein, from Capsicum pepper, contains 166 amino acids, is membrane-bound, locates in Cell membrane.

Required for defense response to Xanthomonas campestris pv, vesicatoria (Xcv), In heterologous systems, confers resistance to bacterial pathogens such as Pseudomonas syringae pv, tomato but susceptibility to pathogenic oomycetes such as Hylaloperonospora parasitica when expressed in Arabidopsis thaliana, May be involved in the regulation of responses to bitoic and abiotic stresses

Belongs to the Casparian strip membrane proteins (CASP) family


This is Caveolae-associated protein 4 protein, from Mouse, contains 362 amino acids, is soluble, locates in Cytoplasm.

Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation, Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation (PubMed:24567387), Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (PubMed:26497963), Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105)


This is Probable tubulin polyglutamylase TTLL9 protein, from Mouse, contains 461 amino acids, is soluble, locates in Cytoplasm.

Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (PubMed:27257088), Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (Probable), Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern (PubMed:27257088)

Belongs to the tubulin--tyrosine ligase family


This is Low-density lipoprotein receptor class A domain-containing protein 3 protein, from Mouse, contains 345 amino acids, is membrane-bound, locates in Cell membrane.

May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production (PubMed:21795536), May regulate ITCH and NEDD4 E3 ligase activity and degradation (By similarity)


This is DNA topoisomerase 6 subunit A3 protein, from Rice, contains 442 amino acids, locates in Nucleus.

Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles, Relaxes both positive and negative superturns and exhibits a strong decatenase activity (By similarity), May be involved in cell proliferation and stress tolerance


This is Gamma-secretase-activating protein protein, from Human, contains 854 amino acids, locates in Golgi apparatus.

Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch, The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein), Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD


This is Tubulin polyglutamylase TTLL11 protein, from Mouse, contains 727 amino acids, is soluble, locates in Cytoplasm.

Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:17499049, PubMed:20530212), Preferentially mediates ATP-dependent polyglutamate long side-chain elongation over the initiation step of the polyglutamylation reaction (PubMed:17499049, PubMed:20530212), Preferentially modifies the alpha-tubulin tail over a beta-tail (PubMed:17499049), Required for CCSAP localization to both spindle and cilia microtubules (By similarity), Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions (PubMed:20530212)


This is Interferon-induced transmembrane protein 5 protein, from Human, contains 132 amino acids, is membrane-bound, locates in Cell membrane.


This is Ribonuclease III domain-containing protein RNC1, chloroplastic protein, from Maize, contains 525 amino acids, is soluble, locates in Plastid.

Binds specific group II introns in chloroplasts and facilitates their splicing, Acts on both subgroup IIA and subgroup IIB introns, The substrates of the subgroup II also require the CRM domain proteins CAF1 or CAF2, Binds both single-stranded and double-stranded RNA non-specifically, but lacks endonuclease activity, Required for plastid ribosome biogenesis


This is E3 ubiquitin-protein ligase NEURL1B protein, from Human, contains 555 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands


This is Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial protein, from Human, contains 240 amino acids, locates in Mitochondrion.

Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria (PubMed:28391595, PubMed:28887308), Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methyl group per binding event (PubMed:28887308)

Belongs to the methyltransferase superfamily


This is Lysosomal amino acid transporter 1 homolog protein, from Rat, contains 293 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes


This is Protein lin-61 protein, from Caenorhabditis elegans, contains 612 amino acids, locates in Nucleus.

Synthetic multivulva class B (synMuvB) protein required to repress the induction of vulval development by Ras signaling, Unlike other synMuv proteins it does not associate with the multiprotein DRM complex and the NuRD-like complex, Interaction with methylated histone H3 is essential for vulva development, It has a role in maintaining genome stability


This is Ubiquitin thioesterase OTUB1 protein, from Rat, contains 271 amino acids, is soluble, locates in Cytoplasm.

Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of 'Lys-63'-linked histone H2A and H2AX marks, Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1, The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved 'Lys48'-linked di-ubiquitin chain (By similarity)


This is Latartoxin-2a protein, from Spider, contains 109 amino acids, is soluble, locates in Extracellular.

Insect toxin, Causes paralysis in larvae of C,vicina by depolarizing membranes at the neuromuscular junction

Belongs to the neurotoxin 19 (CSTX) family, 11 (latartoxin) subfamily


This is Latartoxin-2b protein, from Spider, contains 111 amino acids, is soluble, locates in Extracellular.


This is Latartoxin-2c protein, from Spider, contains 108 amino acids, is soluble, locates in Extracellular.


This is Bifunctional acetylxylan esterase/xylanase XynS20E protein, from Rumen fungus, contains 671 amino acids, is soluble, locates in Extracellular.

Bifunctional acetylxylan esterase/xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose, Degrades xylan from acetylxylan, beechwood, birchwood, and oat spelt, and releases acetate from 4-methylumbelliferyl acetate and beta-D-xylose tetraacetate, No activity is observed against carboxy methyl cellulose, beta-glucan, p-nitrophenol acetate, p-nitrophenol laurate, p-nitrophenol myristate, p-nitrophenol, palmitate, or beta-naphthol acetate

In the C-terminal section; belongs to the glycosyl hydrolase 11 (cellulase G) family


This is Endonuclease III homolog 2, chloroplastic protein, from Mouse-ear cress, contains 386 amino acids, is soluble, locates in Plastid.

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage, The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site, The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, Primarily recognizes and repairs oxidative base damage of pyrimidines


This is Beta-carotene isomerase D27, chloroplastic protein, from Rice, contains 278 amino acids, locates in Plastid.

Involved in strigolactones biosynthesis by catalyzing the isomerization of the C9-C10 double bond in all-trans-beta-carotene leading to 9-cis-beta-carotene and providing the substrate for CCD7, Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signals that stimulate hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds


This is Mapk-regulated corepressor-interacting protein 1 protein, from Human, contains 97 amino acids, locates in Nucleus.

The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition, Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s), When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771)


This is Laccase protein, from White-rot fungus, contains 499 amino acids, is soluble, locates in Extracellular.

Lignin degradation and detoxification of lignin-derived products

Belongs to the multicopper oxidase family


This is Succinate dehydrogenase cytochrome b560 subunit, mitochondrial protein, from Pig, contains 169 amino acids, is membrane-bound, locates in Mitochondrion.

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)


This is E3 ubiquitin-protein ligase CCNB1IP1 protein, from Mouse, contains 276 amino acids, has 1 RING-type; atypical Zinc finger, locates in Nucleus.

RING-type; atypical

Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites, Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites, Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over, Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase, Overexpression causes delayed entry into mitosis


This is Phosphatidylserine decarboxylase proenzyme, mitochondrial protein, from Rat, contains 406 amino acids, locates in Mitochondrion.

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer), Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine, May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity)

Belongs to the phosphatidylserine decarboxylase family, PSD-B subfamily, Eukaryotic type I sub-subfamily


This is Protein PAF1 homolog protein, from Mouse-ear cress, contains 589 amino acids, locates in Nucleus.

Component of the PAF1 complex (PAF1C) which is involved in histone modifications such as methylation on histone H3 'Lys-4' (H3K4me3) (PubMed:20363855), Involved in regulation of flowering time, Required for the expression of the flowering repressors and MAD-box genes FLC, AGL27/FLM and AGL31/MAF2, Required for histone H3 trimethylation on 'Lys-4' H3K4me3 at the FLC and AGL27/FLM loci (PubMed:15520273), Involved in the control of seed dormancy and germination (PubMed:21799800)


This is Splicing factor Cactin protein, from Mouse-ear cress, contains 716 amino acids, locates in Nucleus.

Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity), Required for embryogenesis (PubMed:23454656)


This is BRCA1-associated RING domain protein 1 protein, from Mouse-ear cress, contains 714 amino acids, has 1 RING-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger, has 1 PHD-type Zinc finger, locates in Nucleus.

RING-type

C2HC pre-PHD-type

PHD-type

Binds specifically to H3K4me3 regions of target genes (e,g, WUS and WOX5) promoters to repress their transcription via chromatin remodeling, Required for the shoot apical meristem (SAM) organization and maintenance, by confining WUS expression to the organizing center, and for the quiescent center (QC) development in the root apical meristem (RAM), by repressing WOX5 expression in the root proximal meristem (PubMed:18591352, PubMed:25631790), Plays a role in DNA repair and in cell-cycle control, Required for the repair of DNA double-strand breaks (DSBs), both natural and induced by genotoxic stress, by homologous recombination (HR) (PubMed:16957774)


This is CRIB domain-containing protein RIC3 protein, from Mouse-ear cress, contains 220 amino acids, is soluble, locates in Cytoplasm.

Functions as downstream effector of Rho-related GTP binding proteins of the 'Rho of Plants' (ROPs) family, Participates in the propagation of ROP GTPase signals in specific cellular responses, Functions as downstream effector of ARAC11/ROP1 to activate calcium signaling that leads to F-actin disassembly associated with exocytosis in the tip of the growing pollen tube, Counteracts the ARAC11/ROP1-RIC4 pathway, which promotes apical F-actin assembly associated with vesicle accumulation, to control actin dynamics and pollen tube apical growth


This is Zinc finger protein SHOOT GRAVITROPISM 5 protein, from Mouse-ear cress, contains 445 amino acids, has 3 C2H2-type Zinc finger, has 1 CCHC-type 2; atypical Zinc finger, locates in Nucleus.

CCHC-type 2; atypical

Transcription factor involved in inflorescence stems gravitropism, probably by regulating starch accumulation in amyloplasts of graviperceptive cells, Required for stem circumnutation movements, Regulates lateral organ morphogenesis and gravitropic responses (PubMed:24039602), Acts cooperatively with IDD16 to control silique and branche orientation (PubMed:24039602), Involved in the establishment of auxin gradients through the regulation of auxin biosynthesis and transport (PubMed:24039602)


This is CRIB domain-containing protein RIC1 protein, from Mouse-ear cress, contains 224 amino acids, is soluble, locates in Cytoplasm.

Functions as downstream effector of Rho-related GTP binding proteins of the 'Rho of Plants' (ROPs) family, Participates in the propagation of ROP GTPase signals in specific cellular responses, Required for cortical microtubule organization, Promotes microtubule bundling and formation of well-ordered microtubule arrays in the neck region of pavement cells, This restricts cell lateral expansion to generate the narrow neck morphology of pavement cells, Its function is inhibited when it interacts with activated ARAC4/ROP2, Represses ARAC4/ROP2 activation and antagonizes the RIC4-actin pathway that promotes the assembly of cortical actin microfilaments, Acts as downstream effector of ARAC3/ROP6 which functions in a signaling pathway that negatively regulates clathrin-mediated endocytosis and internalization of PIN1 and PIN2, Required for the asymmetric auxin distribution during root gravitropism and vascular patterning, Positively regulates auxin responses, but negatively regulates ABA responses during lateral root development and primary root elongation


This is Transketolase-2, chloroplastic protein, from Mouse-ear cress, contains 741 amino acids, is membrane-bound, locates in Plastid.

Catalyzes the reversible transfer of a two-carbon ketol group from fructose-6-phosphate or sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to yield xylulose-5-phosphate and erythrose-4-phosphate or ribose-5-phosphate, respectively (By similarity), Could act as a stress sensor involved in adaptation process


This is Pre-mRNA-processing protein 40B protein, from Mouse-ear cress, contains 992 amino acids, locates in Nucleus.

Binds the phosphorylated C-terminal domain (CTD) of the largest subunit of RNA polymerase II and functions as a scaffold for RNA processing machineries (PubMed:10907853), May be involved in pre-mRNA splicing (Probable)


This is Nodulin homeobox protein, from Mouse-ear cress, contains 913 amino acids, locates in Nucleus.

Regulates COOLAIR, a set of antisense transcripts originating from the 3' end of FLOWERING LOCUS C (FLC), Associates with single-stranded DNA that is part of an RNA-DNA hybrid, or R-loop, that covers the COOLAIR promoter, R-loop stabilization mediated by NDX inhibits COOLAIR transcription, which in turn modifies FLC expression


This is Chromatin remodeling protein EBS protein, from Mouse-ear cress, contains 234 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Chromatin remodeling factor that binds to methylated histone (e,g, H3K4me2/3) to prevent their acetylation (e,g, H3K9K14Ac), likely by recruiting histone deacetylase (HDAC) complexes, and thus regulating the transcription of target genes (PubMed:25281686), Negative regulator in developmental processes in a gibberellic acid- (GA-) dependent manner, such as germination, flowering induction, and flower organ specification, probably by modulating developmental gene expression (PubMed:11340178, PubMed:25281686), Involved in the chromatin-mediated repression of floral initiation and controls genes regulating flowering (PubMed:25281686), Negatively regulates the expression of the floral integrator FT epigenetically, by preventing high levels of H3 acetylation, thus maintaining an inactive chromatin conformation at FT locus (PubMed:25281686, PubMed:12837946)


This is Dihydrofolate synthetase protein, from Mouse-ear cress, contains 530 amino acids, is soluble, locates in Mitochondrion.

Conversion of folates to polyglutamate derivatives, including tetrahydrofolate (PubMed:11752472, PubMed:12535338), Required during embryogenesis; from maternal tissues until the globular stage, and from the embryo after the globular stage (PubMed:12535338)

Belongs to the folylpolyglutamate synthase family


This is Calmodulin-binding protein 60 G protein, from Mouse-ear cress, contains 563 amino acids, locates in Nucleus.

Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes (PubMed:20921422, PubMed:21615571, PubMed:23153277, PubMed:29757140), Recruited to the promoter of ICS1 and other defense-related genes (e,g, PR1, PR2 and EDS5) in response to both biotic (e,g, Pseudomonas syringae pv, maculicola ES4326, P, syringae pv, tomato DC3000, and microbe-associated molecular patterns (MAMPs) such as flg22) and abiotic stresses (e,g, UV-B, drought and abscisic acid), thus triggering rapid defense responses by stimulating salicylic acid (SA) biosynthesis, Involved in basal and systemic acquired resistance to P, syringae and Hyaloperonospora arabidopsidis (PubMed:20921422, PubMed:21615571, PubMed:22466450, PubMed:19214217), Mediates resistance to drought and sensitivity to abscisic acid (ABA), especially for ABA-mediated signaling process that regulates early seedling growth (PubMed:22466450)

Belongs to the plant ACBP60 protein family


This is Membrane protein of ER body 2 protein, from Mouse-ear cress, contains 550 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May sequester excess cytosolic iron and manganese into endoplasmic reticulum to reduce metal ion toxicity, Not essential for the accumulation of ER body components, including PYK10


This is MORC family CW-type zinc finger protein 3 protein, from Mouse, contains 942 amino acids, has 1 CW-type Zinc finger, is soluble, locates in Nucleus.

CW-type

Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response, Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function, Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504), Binds RNA in vitro, Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3, The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0


This is Cholesteryl ester transfer protein protein, from Chinese hamster, contains 492 amino acids, is soluble, locates in Extracellular.

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles, Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:24293641), Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity)

Belongs to the BPI/LBP/Plunc superfamily, BPI/LBP family


This is Nuclear hormone receptor family member daf-12 protein, from Caenorhabditis elegans, contains 753 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Nuclear receptor which binds directly to response elements in target gene promoters (PubMed:9477318, PubMed:10859169, PubMed:15314028, PubMed:15489294, PubMed:15383841, PubMed:15611047, PubMed:16626392, PubMed:19828440, PubMed:21814518), Activity is modulated by binding of steroid hormone ligands that include dafachronic acids (PubMed:16529801), Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues (PubMed:9477318, PubMed:10859169, PubMed:15489294, PubMed:15383841, PubMed:16626392, PubMed:19828440, PubMed:21814518), Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1 (PubMed:19828440), Plays a role in controlling the timing of seam cell development during the larval stages (PubMed:21471153), Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs (PubMed:23990780), Controls expression of genes that promote the aerobic catabolism of fatty acids for reproductive growth (PubMed:25774872), May be involved in thermotolerance (PubMed:24957743)

Belongs to the nuclear hormone receptor family


This is DNA helicase MCM8 protein, from Chicken, contains 830 amino acids, locates in Nucleus.

Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis, The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart


This is Golgi-associated olfactory signaling regulator protein, from Mouse, contains 504 amino acids, is membrane-bound, locates in Golgi apparatus.

Required for proper function of the olfactory system, May be involved in establishing the acuity of olfactory sensory signaling


This is Neoxanthin synthase, chloroplastic protein, from Tomato, contains 498 amino acids, locates in Plastid.

Involved in the synthesis of neoxanthin, the last product of carotenoid synthesis and a precursor of abscisic acid (PubMed:11029576), Involved in the beta-carotene biosynthesis (PubMed:10995464)


This is (S)-8-oxocitronellyl enol synthase protein, from Madagascar periwinkle, contains 388 amino acids, is soluble, locates in Cytoplasm.

Iridoid synthase that catalyzes the first step in generation of the iridoid ring scaffold using the linear monoterpene (6E)-8-oxogeranial as substrate, Iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and antibacterial activities

Belongs to the short-chain dehydrogenases/reductases (SDR) family, Highly divergent


This is TNF receptor-associated factor 5 protein, from Human, contains 557 amino acids, has 1 RING-type Zinc finger, has 2 TRAF-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

TRAF-type

TRAF-type

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases, Mediates activation of NF-kappa-B and probably JNK, Seems to be involved in apoptosis, Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR

Belongs to the TNF receptor-associated factor family, A subfamily


This is Peroxisome assembly protein 12 protein, from Human, contains 359 amino acids, has 1 RING-type; degenerate Zinc finger, is membrane-bound, locates in Peroxisome.

RING-type; degenerate

Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:9354782, PubMed:9632816, PubMed:24662292), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (PubMed:24662292), When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)


This is Putative transcriptional regulator cudA protein, from Social amoeba, contains 802 amino acids, is soluble, locates in Nucleus.

Essential for normal culmination, May function as a transcriptional regulator


This is Cyclic phosphodiesterase protein, from Mouse-ear cress, contains 181 amino acids, is soluble, locates in Cytoplasm.

Hydrolyzes ADP-ribose 1'',2''-cyclic phosphate (Appr>1) that is produced during tRNA splicing into ADP-ribose 1''-phosphate (Appr-1''p) (PubMed:9148938), Acts also on nucleoside 2',3'-cyclic phosphates (PubMed:9148938)

Belongs to the 2H phosphoesterase superfamily, CPD1 family


This is Isoamylase 1, chloroplastic protein, from Mouse-ear cress, contains 783 amino acids, locates in Plastid.

Involved in the trimming of pre-amylopectin chains, Accelerates the crystallization of nascent amylopectin molecules during starch synthesis, ISA1 and ISA2 work exclusively together as a multimeric holoenzyme, ISA1-ISA2 removes preferentially branches that are very close to other branches, Promotes negative gravitropic responses in shoots by facilitating starch granules (statoliths) formation in hypocotyls (PubMed:34367195)

Belongs to the glycosyl hydrolase 13 family


This is Eukaryotic translation initiation factor 3 subunit F protein, from Mouse-ear cress, contains 293 amino acids, is soluble, locates in Cytoplasm.

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome, The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential), Involved in cell growth and differentiation, especially during embryogenesis and male gametophyte germination (PubMed:20444226), Regulates sensitivity to sugars (e,g, sucrose) (PubMed:20444226)


This is Protein ASYMMETRIC LEAVES 2 protein, from Mouse-ear cress, contains 199 amino acids, locates in Nucleus.

Negative regulator of cell proliferation in the adaxial side of leaves, Regulates the formation of a symmetric lamina and the establishment of venation, Positively regulates LATERAL ORGAN BOUNDARIES (LOB) within the shoot apex, and the class III HD-ZIP genes REV, PHB, and PHV, Interacts directly with ASYMMETRIC LEAVES 1 (AS1) to repress the knox homeobox genes KNAT1, KNAT2, and KNAT6 and the abaxial determinants ARF3, KAN2 and YAB5, May act in parallel with the RDR6-SGS3-AGO7 pathway, an endogenous RNA silencing pathway, to regulate the leaf morphogenesis (PubMed:11311158, PubMed:12787254, PubMed:12874130, PubMed:14508003, PubMed:16006579, PubMed:16699177, PubMed:17395603, PubMed:17559509), Required for the binding of AS1 to the KNOX genes (PubMed:23271976), Involved in leaf polarity establishment by functioning cooperatively with RH10 or RID2 to repress abaxial genes ARF3, ARF4, KAN1, KAN2, YAB1 and YAB5, and the knox homeobox genes KNAT1, KNAT2, KNAT6, and STM to promote adaxial development in leaf primordia at shoot apical meristems at high temperatures (PubMed:27334696)

Belongs to the LOB domain-containing protein family


This is Netrin receptor UNC5B protein, from Rat, contains 945 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance, Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding, Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (PubMed:10399920, PubMed:9126742), Functions as netrin receptor that negatively regulates vascular branching during angiogenesis, Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity), It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:11387206), Mediates apoptosis by activating DAPK1 (PubMed:18582460), In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (PubMed:15729359)


This is Nuclear factor interleukin-3-regulated protein protein, from Mouse, contains 462 amino acids, locates in Nucleus.

Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters, Represses transcription from promoters with activating transcription factor (ATF) sites (By similarity), Represses promoter activity in osteoblasts, Represses transcriptional activity of PER1, Represses transcriptional activity of PER2 via the B-site on the promoter, Activates transcription from the interleukin-3 promoter in T-cells (By similarity), Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF), Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock, Protects pro-B cells from programmed cell death, Represses the transcription of CYP2A5 (PubMed:30555544), Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (PubMed:29653076), Required for the development of natural killer cell precursors (PubMed:32190943)

Belongs to the bZIP family, NFIL3 subfamily


This is Somatostatin receptor type 5 protein, from Mouse, contains 362 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for somatostatin-28, The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, Increases cell growth inhibition activity of SSTR2 following heterodimerization

Belongs to the G-protein coupled receptor 1 family


This is Monopolin complex subunit pcs1 protein, from Fission yeast, contains 261 amino acids, locates in Nucleus.

The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II, May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules, In contrast to its S,cerevisiae ortholog CSM1, is not required ofr mono-orientation during meiosis I


This is Glucan endo-1,3-alpha-glucosidase agn1 protein, from Fission yeast, contains 424 amino acids, is soluble, locates in Extracellular.

Has a role in cell separation where it is required for the degradation of the cell wall material surrounding the septum (the septum edging) which must be hydrolyzed before full separation of the daughter cells can occur, Hydrolyzes 1,3-alpha-glucan predominantly into pentasaccharides

Belongs to the glycosyl hydrolase 71 family


This is Cohesin subunit psc3 protein, from Fission yeast, contains 962 amino acids, locates in Nucleus.

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication, The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped, At anaphase, the rad21 subunit of the cohesin complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate, The cohesin complex may also play a role in spindle pole assembly during mitosis


This is Cryptic loci regulator 2 protein, from Fission yeast, contains 537 amino acids, locates in Nucleus.

Required for deacetylation in the mating-type region and the centromere, Acts upstream of the histone deacetylases to promote transcriptional silencing, Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC)


This is Transcription elongation factor spt5 protein, from Fission yeast, contains 990 amino acids, locates in Nucleus.

The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing, This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity)


This is Cytochrome P450 regulator dap1 protein, from Fission yeast, contains 166 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for sterol biosynthesis, Functions as a positive regulator of cytochrome P450 enzymes erg5 and erg11, Function requires bound heme

Belongs to the cytochrome b5 family, MAPR subfamily


This is Elongator complex protein 3 protein, from Fission yeast, contains 544 amino acids, is soluble, locates in Cytoplasm.

Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:22768388), In the elongator complex, acts as a tRNA uridine(34) acetyltransferase, which mediates formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity)


This is Small nuclear ribonucleoprotein Sm D2 protein, from Fission yeast, contains 115 amino acids, locates in Nucleus.

Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity)

Belongs to the snRNP core protein family


This is Protection of telomeres protein tpz1 protein, from Fission yeast, contains 508 amino acids, locates in Nucleus.

Telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang and involved in telomere length regulation, recruits poz1 and ccq1 to telomeres, regulating telomere length negatively and positively respectively


This is Free fatty acid receptor 3 protein, from Human, contains 346 amino acids, is membrane-bound, locates in Cell membrane.

G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity, In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers, SCFAs serve as a source of energy but also act as signaling molecules, That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins, Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604), Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases, Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate, Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis, May also control the production of hormones involved in whole-body energy homeostasis, May for instance, regulate blood pressure through renin secretion, May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota, May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine, Finally, may also play a role in glucose homeostasis, Besides its role in energy homeostasis, may play a role in intestinal immunity, May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells, Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed:12496283, PubMed:12711604)


This is Mitochondrial import inner membrane translocase subunit Tim23 protein, from Human, contains 209 amino acids, is membrane-bound, locates in Mitochondrion.

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane


This is Mitochondrial ribonuclease P catalytic subunit protein, from Human, contains 583 amino acids, locates in Mitochondrion.

Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853, PubMed:34715011), The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853)


This is NF-kappa-B-repressing factor protein, from Human, contains 690 amino acids, locates in Nucleus.

Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793), Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793), Also involved in the regulation of IL-8 transcription (PubMed:12381793), May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553)


This is Solute carrier family 22 member 1 protein, from Human, contains 554 amino acids, is membrane-bound, locates in Cell membrane.

Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+))

Belongs to the major facilitator (TC 2,A,1) superfamily, Organic cation transporter (TC 2,A,1,19) family


This is E3 ubiquitin-protein ligase Midline-1 protein, from Human, contains 667 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

B box-type

B box-type

Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination


This is Insulin-induced gene 1 protein protein, from Human, contains 277 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062), Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:32322062), Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062), In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062), Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062), Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767), Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676)


This is Transcription factor MafG protein, from Human, contains 162 amino acids, locates in Nucleus.

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691), However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691), Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691), Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691), Activates globin gene expression when associated with NFE2L2 (PubMed:11154691), May be involved in signal transduction of extracellular H(+) (By similarity)

Belongs to the bZIP family, Maf subfamily


This is Protein muscleblind protein, from Fruit fly, contains 297 amino acids, has 2 C3H1-type Zinc finger, locates in Nucleus.

Required for terminal differentiation of photoreceptor cells, Vital for embryonic development


This is Stress-induced-phosphoprotein 1 protein, from Caenorhabditis elegans, contains 320 amino acids, is soluble, locates in Cytoplasm.

Plays a role in gonad development, Up-regulates longevity and thermotolerance, Binds daf-21/hsp90 and inhibits its ATPase activity


This is Transketolase, chloroplastic protein, from Spinach, contains 741 amino acids, is membrane-bound, locates in Plastid.

Catalyzes the reversible transfer of a two-carbon ketol group from fructose-6-phosphate or sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to yield xylulose-5-phosphate and erythrose-4-phosphate or ribose-5-phosphate, respectively


This is Ubiquinol oxidase 2, mitochondrial protein, from Mouse-ear cress, contains 353 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the cyanide-resistant oxidation of ubiquinol and the reduction of molecular oxygen to water, but does not translocate protons and consequently is not linked to oxidative phosphorylation, May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures (By similarity)

Belongs to the alternative oxidase family


This is LOB domain-containing protein 18 protein, from Mouse-ear cress, contains 262 amino acids, locates in Nucleus.

Involved in the positive regulation of tracheary element (TE) differentiation, Involved in a positive feedback loop that maintains or promotes NAC030/VND7 expression that regulates TE differentiation-related genes (PubMed:19088331), Functions in the initiation and emergence of lateral roots, in conjunction with LBD16, downstream of ARF7 and ARF19 (PubMed:19717544, PubMed:23749813), Transcriptional activator that directly regulates EXPA14, a gene encoding a cell wall-loosening factor that promotes lateral root emergence, Activates EXPA14 by directly binding to a specific region of its promoter (PubMed:22974309), Transcriptional activator that directly regulates EXPA17, a gene encoding a cell wall-loosening factor that promotes lateral root emergence (PubMed:23872272), Acts downstream of the auxin influx carriers AUX1 and LAX1 in the regulation of lateral root initiation and development (PubMed:26059335)


This is Serine/arginine-rich-splicing factor SR34 protein, from Mouse-ear cress, contains 303 amino acids, is soluble, locates in Nucleus.

General splicing factor, Can promote splice site selection in vitro presumably by antagonizing the effects of the A1 heterogeneous nuclear ribonucleoprotein, May have an essential function during early plant development

Belongs to the splicing factor SR family, SR subfamily


This is Protease Do-like 1, chloroplastic protein, from Mouse-ear cress, contains 439 amino acids, is membrane-bound, locates in Plastid.

Serine protease that is required at high temperature, May be involved in the degradation of damaged proteins, In vivo, can degrade beta-casein


This is Patatin-like protein 1 protein, from Mouse-ear cress, contains 414 amino acids, is soluble, locates in Cytoplasm.

Possesses non-specific lipolytic acyl hydrolase (LAH) activity, Catalyzes the hydrolysis of the neutral lipids monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and phosphatidylglycerol (PG), and less efficiently the polar lipids phosphatidylcholine (PC) and phosphatidylinositol (PI), but not the storage lipid triacylglycerol (TAG), May play a role in root development


This is Patatin-like protein 3 protein, from Mouse-ear cress, contains 428 amino acids, is soluble, locates in Cytoplasm.


This is Calmodulin-binding transcription activator 5 protein, from Mouse-ear cress, contains 923 amino acids, locates in Nucleus.

Transcription activator (PubMed:14581622), Binds to the DNA consensus sequence 5'-[ACG]CGCG[GTC]-3' (By similarity), Regulates transcriptional activity in response to calcium signals (Probable), Binds calmodulin in a calcium-dependent manner (By similarity), Involved in response to cold, Contributes together with CAMTA3 to the positive regulation of the cold-induced expression of DREB1A/CBF3, DREB1B/CBF1 and DREB1C/CBF2 (PubMed:28351986)


This is 1,4-alpha-glucan-branching enzyme 2-1, chloroplastic/amyloplastic protein, from Mouse-ear cress, contains 858 amino acids, is soluble, locates in Plastid.

Catalyzes the formation of the alpha-1,6-glucosidic linkages in starch by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position

Belongs to the glycosyl hydrolase 13 family, GlgB subfamily


This is Diphosphomevalonate decarboxylase MVD1, peroxisomal protein, from Mouse-ear cress, contains 412 amino acids, locates in Peroxisome.

Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids (PubMed:10344201, PubMed:26216978), Is specific for (R)-5-diphosphomevalonate (MVAPP), The catalytic efficiency with (R)-5-phosphomevalonate (MVAP) as substrate is 10000-fold lower than for MVAPP (PubMed:26216978), Can complement a yeast mutant defective in MVD activity (PubMed:10344201)

Belongs to the diphosphomevalonate decarboxylase family


This is Betaine aldehyde dehydrogenase 1 protein, from Rice, contains 505 amino acids, locates in Peroxisome.

Dehydrogenase that can use N-acetyl-gamma-aminobutyraldehyde (NAGABald), gamma-guanidinobutyraldehyde (GGBald), betaine aldehyde (Bet-ald), gamma-aminobutyraldehyde (GAB-ald), acetaldehyde, 4-aminobutylaldehyde (AB-ald), 3-aminopropionaldehyde (AP-ald), 4-N-trimethylaminobutyraldehyde (TMAB-ald) and 3-N-trimethylaminopropionaldehyde (TMAP-ald) as substrates, Catalyzes the oxidation of GAB-ald more efficiently than Bet-ald, May convert acetaldehyde into acetate, thus facilitating the production of acetyl-CoA in peroxisomes under anaerobic conditions

Belongs to the aldehyde dehydrogenase family


This is Golgi reassembly-stacking protein 1 protein, from Rat, contains 451 amino acids, is membrane-bound, locates in Golgi apparatus.

Key structural protein of the Golgi apparatus (By similarity), The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (By similarity), Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (By similarity), However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (PubMed:12839990, PubMed:23940043, PubMed:9346242), Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (PubMed:11815631, PubMed:12015985), Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (By similarity), Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity)


This is Zinc finger protein ZFPM1 protein, from Mouse, contains 995 amino acids, has 5 CCHC FOG-type Zinc finger, has 4 C2H2-type Zinc finger, locates in Nucleus.

CCHC FOG-type

CCHC FOG-type

CCHC FOG-type

CCHC FOG-type

CCHC FOG-type

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation, Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3, Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context, The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1, May be involved in regulation of some genes in gonads, May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2

Belongs to the FOG (Friend of GATA) family


This is Phosphomannomutase 1 protein, from Mouse, contains 262 amino acids, is soluble, locates in Cytoplasm.

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions, In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain


This is Small ribosomal subunit protein RACK1 protein, from Zebrafish, contains 317 amino acids, is soluble, locates in Cytoplasm.

Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules, Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity), Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation

Belongs to the WD repeat G protein beta family, Ribosomal protein RACK1 subfamily


This is Visual system homeobox 1 protein, from Zebrafish, contains 344 amino acids, locates in Nucleus.

May be involved in maintenance as well as cellular differentiation of retinal interneurons, such as bipolar cells, May play a role in establishing interneuronal cell classes in nonsensory as well as sensory systems


This is Cell wall mannoprotein 1 protein, from Penicillium marneffei, contains 462 amino acids, is soluble, locates in Extracellular.

Constitutive protein of the cell wall, Binds fatty acids and may thus serve as a fatty acid transporter between P,marneffei and host cells during infection (PubMed:20053994), Abundant antigen target of host humoral immune response (PubMed:9488383)

Belongs to the cell wall mannoprotein 1 family


This is Cytosolic neutral trehalase protein, from Fission yeast, contains 735 amino acids, is soluble, locates in Cytoplasm.

Hydrolyzes intracellular trehalose to glucose (PubMed:12153582), The disaccharide trehalose serves as a storage carbohydrate that is mobilized during nutrient stress and spore germination (PubMed:11094289), Together with tps1, regulates the level of trehalose as a protectant for cell integrity during heat, osmotic and oxidative stresses (PubMed:9495778, PubMed:9974219, PubMed:12943532, PubMed:15965643)

Belongs to the glycosyl hydrolase 37 family


This is Eukaryotic translation initiation factor 3 subunit F protein, from Fission yeast, contains 302 amino acids, is soluble, locates in Cytoplasm.

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome, The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation


This is Zinc finger HIT domain-containing protein 1 protein, from Human, contains 154 amino acids, has 1 HIT-type Zinc finger, locates in Nucleus.

HIT-type

Plays a role in chromatin remodeling by promoting the incorporation of histone variant H2AZ1/H2A,Z into the genome to regulate gene expression (PubMed:20473270, PubMed:35175558), Promotes SRCAP complex-mediated deposition of histone variant H2AZ1 to lymphoid fate regulator genes, enhancing lymphoid lineage commitment (By similarity), Recruited to the promoter of the transcriptional activator MYOG at the early stages of muscle differentiation where it mediates binding of histone H2AZ1 to chromatin and induces muscle-specific gene expression (PubMed:20473270), Maintains hematopoietic stem cell (HSC) quiescence by determining the chromatin accessibility at distal enhancers of HSC quiescence genes such as PTEN, FSTL1 and KLF4, enhancing deposition of H2AZ1 to promote their sustained transcription and restricting PI3K-AKT signaling inhibition (By similarity), Plays a role in intestinal stem cell maintenance by promoting H2AZ1 deposition at the transcription start sites of genes involved in intestinal stem cell fate determination including LGR5, TGFB1 and TGFBR2, thereby contributing to gene transcription (By similarity), Promotes phosphorylation of the H2AZ1 chaperone VPS72/YL1 which enhances the interaction between HZAZ1 and VPS72 (By similarity), Regulates the entry of male germ cells into meiosis by controlling histone H2AZ1 deposition which facilitates the expression of meiotic genes such as MEIOSIN, leading to the initiation of meiosis (By similarity), Required for postnatal heart function through its role in maintenance of cardiac Ca(2+) homeostasis by modulating the expression of Ca(2+)-regulating proteins CASQ1 and ATP2A2/SERCA2A via deposition of histone H2AZ1 at their promoters (By similarity), During embryonic heart development, required for mitochondrial maturation and oxidative metabolism by functioning through H2AZ1 deposition to activate transcription of metabolic genes and is also required to maintain the stability of the respiratory complex (By similarity), In neural cells, increases deposition of the H2AZ1 histone variant and promotes neurite growth (PubMed:35175558), Plays a role in TP53/p53-mediated apoptosis induction by stimulating the transcriptional activation of several proapoptotic p53 target genes such as PMAIP1/NOXA and BBC3/PUMA (PubMed:17380123), Mediates cell cycle arrest induced in response to gamma-irradiation by enhancing recruitment of TP53/p53 to the promoter of the cell cycle inhibitor CDKN1A, leading to its transcriptional activation (PubMed:17700068), Recruited to the promoter of cyclin-dependent kinase CDK6 and inhibits its transcription, possibly by decreasing the acetylation level of histone H4, leading to cell cycle arrest at the G1 phase (By similarity), Plays a role in lens fiber cell differentiation by regulating the expression of cell cycle regulator CDKN1A/p21Cip1 (By similarity), Binds to transcriptional repressor NR1D2 and relieves it of its inhibitory effect on the transcription of apolipoprotein APOC3 without affecting its DNA-binding activity (PubMed:17892483)


This is Cochlin protein, from Human, contains 550 amino acids, is soluble, locates in Extracellular.

Plays a role in the control of cell shape and motility in the trabecular meshwork


This is Cleavage and polyadenylation specificity factor subunit 5 protein, from Human, contains 227 amino acids, locates in Nucleus.

Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:15937220, PubMed:17024186, PubMed:17098938, PubMed:29276085), CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:17024186), Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:17098938, PubMed:23187700, PubMed:29276085), The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:17098938, PubMed:20695905, PubMed:29276085), NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7 (PubMed:29276085), Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing (PubMed:8626397, PubMed:14690600, PubMed:15169763, PubMed:17024186, PubMed:22813749, PubMed:20479262), The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA (PubMed:20479262, PubMed:21295486), Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function (By similarity), Binds to chromatin (By similarity), Binds to, but does not hydrolyze mono- and di-adenosine nucleotides (PubMed:18445629)

Belongs to the Nudix hydrolase family, CPSF5 subfamily


This is Respiratory burst oxidase homolog protein F protein, from Mouse-ear cress, contains 944 amino acids, is membrane-bound, locates in Cell membrane.

Calcium-dependent NADPH oxidase that generates superoxide, Generates reactive oxygen species (ROS) during incompatible interactions with pathogens and is important in the regulation of the hypersensitive response (HR), Involved in abscisic acid-induced stomatal closing and in UV-B and abscisic acid ROS-dependent signaling


This is Patatin-like protein 2 protein, from Mouse-ear cress, contains 407 amino acids, is soluble, locates in Cytoplasm.

Possesses non-specific lipolytic acyl hydrolase (LAH) activity, Catalyzes the hydrolysis of the galactolipids monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG), and less efficiently the phoshpolipids phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylglycerol (PG), phosphatidic acid (PA), phosphatidylserine (PS) and phosphatidylinositol (PI), Favors the release of fatty acid at the sn-1 position for PC or PE and the sn-2 position for PG, PA, PS and PI, Negatively affects disease resistance to the necrotic fungal pathogen Botrytis cinerea and the avirulent bacteria Pseudomonas syringae by promoting cell death and reducing the efficiency of the hypersensitive response, respectively, However, PLP2 contributes to resistance to cucumber mosaic virus (CMV), an obligate parasite inducing hypersensitive response, May negatively regulate oxylipin production, possibly via participating in membrane repair that includes removal of oxidatively modified lipids


This is Serine/threonine-protein kinase BIK1 protein, from Mouse-ear cress, contains 395 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Xanthomonas campestris effector AvrAC/XopAC-mediated uridylylation prevents activation by phosphorylation at the same residues, thus affecting immune responses and reducing defense responses toward X,campestris, mediating avrAC/XopAC virulence functions

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Two-component response regulator ARR10 protein, from Mouse-ear cress, contains 552 amino acids, locates in Nucleus.

Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3', Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system, Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes, Could directly activate some type-A response regulators in response to cytokinins

Belongs to the ARR family, Type-B subfamily


This is Polygalacturonase QRT3 protein, from Mouse-ear cress, contains 481 amino acids, is soluble, locates in Extracellular.

Polygalacturonase required for degrading the pollen mother cell wall during microspore development

Belongs to the glycosyl hydrolase 28 family


This is Phospholipase A1-IIgamma protein, from Mouse-ear cress, contains 419 amino acids, is soluble, locates in Cytoplasm.

Acylhydrolase that catalyzes the hydrolysis of 1,3-diacylglycerol (1,3-DAG) and 1-monoacylglycerol (1-MAG) at the sn-1 position, High activity toward 1,3-DAG and 1-MAG, but low activity toward 1,2-diacylglycerol (1,2-DAG) and 1-lysophosphatidylcholine (1-LPC), and no activity toward phosphatidylcholine (PC), monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG), triacylglycerol (TAG) and 2-monoacylglycerol (2-MAG), May be involved in the negative regulation of seedling establishment by inhibiting the breakdown, beta-oxidation and mobilization of seed storage oils

Belongs to the AB hydrolase superfamily, Lipase family


This is High mobility group B protein 5 protein, from Mouse-ear cress, contains 125 amino acids, locates in Nucleus.

Binds preferentially double-stranded DNA, Confers resistance to salt and drought stresses


This is Transcription factor MYB51 protein, from Mouse-ear cress, contains 352 amino acids, locates in Nucleus.

Transcription factor positively regulating indolic glucosinolate biosynthetic pathway genes


This is Cone-rod homeobox protein protein, from Mouse, contains 299 amino acids, locates in Nucleus.

Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes, Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription, Essential for the maintenance of mammalian photoreceptors


This is Deleted in azoospermia-like-A protein, from African clawed frog, contains 286 amino acids, is soluble, locates in Cytoplasm.

RNA-binding protein that is required for primordial germ cell (PGC) differentiation and indirectly necessary for the migration of PGCs through the endoderm, May promote meiotic cell division during spermatogenesis, Shows a preference for G- and U-rich RNAs and probably binds the 3'-UTR of target mRNAs, Stimulates the initiation of translation of mRNAs through the recruitment of poly(A)-binding proteins (PABPs)


This is PWWP domain-containing protein 1 protein, from Fission yeast, contains 359 amino acids, locates in Nucleus.

Necessary for DNA damage checkpoint activation, Required for the association of set9 with chromatin and subsequent methylation of H4K20, Associates with H4K20me1 to increase the concentration of set9 on chromatin to perform H4K20me3, H4K20me3 is mainly enriched at heterochromatin and is required for proper heterochromatin assembly


This is Spindle pole body-associated protein cut12 protein, from Fission yeast, contains 548 amino acids, is soluble, locates in Cytoplasm.

Required for bipolar spindle formation, May act as a regulator of the p34cdc2/cyclin B kinase, Required for full activation of the plo1 kinase, However, in cut12,1 cells at restrictive temperature the H1 kinase does rise concomitant with entry into mitosis, indicating that cut12 is not required for activation of p34cdc2/cyclin B, The cut12,s11 allele may promote cdc2-independent phosphorylation of SPB proteins thereby overcoming the requirement for cdc25 in cell cycle progression


This is Acetylxylan esterase 2 protein, from Soft rot fungus, contains 234 amino acids, is soluble, locates in Extracellular.

Degrades acetylated xylans by cleaving acetyl side groups from the hetero-xylan backbone

Belongs to the cutinase family, Acetylxylan esterase subfamily


This is Protein phosphatase 1 regulatory subunit 12B protein, from Human, contains 982 amino acids, is soluble, locates in Cytoplasm.

Regulates myosin phosphatase activity, Augments Ca(2+) sensitivity of the contractile apparatus


This is BMP/retinoic acid-inducible neural-specific protein 1 protein, from Human, contains 761 amino acids, is soluble, locates in Cytoplasm.

Plays a role in neurogenesis and brain development (By similarity), May suppress cell cycle progression in postmitotic neurons by inhibiting G1/S transition (PubMed:11420708)


This is Integral membrane protein GPR137B protein, from Human, contains 399 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Acts also as a negative regulator of osteoclast activity (By similarity), Involved in interleukin-4-induced M2 macrophage polarization (By similarity)


This is Pre-mRNA-processing factor 17 protein, from Human, contains 579 amino acids, locates in Nucleus.

Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177), Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177)


This is Tetraspanin-1 protein, from Human, contains 241 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Belongs to the tetraspanin (TM4SF) family


This is E3 ubiquitin-protein ligase TRIM13 protein, from Human, contains 407 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type

B box-type

Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD), This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins, Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation, Regulates ER stress-induced autophagy, and may act as a tumor suppressor (PubMed:22178386), Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway, Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation (PubMed:28087809), Participates as well in T-cell receptor-mediated NF-kappa-B activation (PubMed:25088585), In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B (PubMed:25152375)


This is Receptor activity-modifying protein 3 protein, from Human, contains 148 amino acids, is membrane-bound, locates in Cell membrane.

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner, Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane, Acts as a receptor for adrenomedullin (AM) together with CALCRL


This is Katanin p60 ATPase-containing subunit A1 protein, from Purple sea urchin, contains 516 amino acids, is soluble, locates in Cytoplasm.

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner, Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation, In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux

Belongs to the AAA ATPase family, Katanin p60 subunit A1 subfamily


This is Serine/threonine-protein kinase grp protein, from Fruit fly, contains 512 amino acids, locates in Nucleus.

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA, May also negatively regulate cell cycle progression during unperturbed cell cycles, May phosphorylate the CDC25 phosphatase stg, which promotes its degradation, This results in increased inhibitory tyrosine phosphorylation of Cdk1-cyclin complexes and consequent inhibition of cell cycle progression

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily


This is E3 ubiquitin-protein ligase RMA1 protein, from Mouse-ear cress, contains 249 amino acids, has 1 RING-type Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of aquaporin PIP2-1, Forms a ubiquitin ligase complex in cooperation with the E2 enzymes UCB8/UCB10


This is Histone-lysine N-methyltransferase MEDEA protein, from Mouse-ear cress, contains 689 amino acids, locates in Nucleus.

Polycomb group (PcG) protein, Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes, Required to prevent the proliferation of the central cell of the female gametophyte by repressing target genes before fertilization, After fertilization, it probably also regulates the embryo and endosperm proliferation and anteroposterior organization during seed development, PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development, PcG proteins are not required to initiate repression, but to maintain it during later stages of development, Interacts with the promoter and repress the transcription of genes such as PHE1 and PHE2, that are paternally active and maternally silenced genes

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily


This is Leucine-rich repeat extensin-like protein 1 protein, from Mouse-ear cress, contains 744 amino acids, is soluble, locates in Extracellular.

Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization, Together with LRX2, component of the extracellular mechanism regulating root hair morphogenesis and elongation


This is Zinc finger protein Gfi-1b protein, from Mouse, contains 330 amino acids, has 6 C2H2-type Zinc finger, locates in Nucleus.

Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages, Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation, Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways, Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate, Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells, Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells, Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction, Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression, Alters histone methylation by recruiting histone methyltransferase to target genes promoters, Plays a role in heterochromatin formation


This is Receptor for retinol uptake STRA6 protein, from Mouse, contains 670 amino acids, is membrane-bound, locates in Cell membrane.

Functions as retinol transporter (PubMed:23839944, PubMed:24852372), Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1, Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (By similarity), Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:23839944), Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid and 11-cis-retinal (PubMed:22467576, PubMed:24852372), STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (PubMed:22467576, PubMed:23839944, PubMed:24852372), Does not transport retinoic acid (By similarity)


This is E3 ubiquitin-protein ligase brl2 protein, from Fission yeast, contains 680 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1, H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation


This is DNA replication licensing factor mcm7 protein, from Fission yeast, contains 760 amino acids, locates in Nucleus.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity), Required for the progression of S phase (PubMed:11606526)


This is Ribitol-5-phosphate transferase FKTN protein, from Human, contains 461 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:26923585, PubMed:29477842, PubMed:27194101), This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:29477842, PubMed:27194101), Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity (PubMed:17034757), May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes (PubMed:25279699), Could be involved in brain development (Probable)


This is Serine/threonine-protein phosphatase 6 regulatory subunit 2 protein, from Human, contains 966 amino acids, is soluble, locates in Cytoplasm.

Regulatory subunit of protein phosphatase 6 (PP6), May function as a scaffolding PP6 subunit, Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha


This is Stannin protein, from Human, contains 88 amino acids, is membrane-bound, locates in Mitochondrion.

Plays a role in the toxic effects of organotins (PubMed:15269288), Plays a role in endosomal maturation (PubMed:27015288)


This is Core histone macro-H2A.1 protein, from Human, contains 369 amino acids, locates in Nucleus.

In contrast to isoform 1, does not bind poly-ADP-ribose (PubMed:15902274), Represses SOD3 gene expression (PubMed:23022728)


This is Cytokine receptor-like factor 1 protein, from Human, contains 422 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is soluble, locates in Extracellular.

Ig-like C2-type

In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable), May also play a regulatory role in the immune system

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is PC4 and SFRS1-interacting protein protein, from Human, contains 530 amino acids, locates in Nucleus.

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis, Involved in particular in lens epithelial cell gene regulation and stress responses, May play an important role in lens epithelial to fiber cell terminal differentiation, May play a protective role during stress-induced apoptosis, Isoform 2 is a more general and stronger transcriptional coactivator, Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing, Cellular cofactor for lentiviral integration


This is WW domain-binding protein 4 protein, from Human, contains 376 amino acids, has 1 Matrin-type Zinc finger, locates in Nucleus.

Matrin-type

Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:9724750, PubMed:19592703, PubMed:28781166), May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750)


This is Nucleoplasmin-3 protein, from Human, contains 178 amino acids, locates in Nucleus.

Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning (PubMed:22362753, PubMed:20073534), Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM (PubMed:22362753), Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM (PubMed:15596447)


This is Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial protein, from Human, contains 557 amino acids, locates in Mitochondrion.

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria, The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)

Belongs to the GatB/GatE family, GatB subfamily


This is Cyclin-K protein, from Human, contains 580 amino acids, locates in Nucleus.

Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases, Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A)

Belongs to the cyclin family, Cyclin C subfamily


This is Pre-mRNA-splicing factor SPF27 protein, from Human, contains 225 amino acids, locates in Nucleus.

Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961, PubMed:30705154), Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing, May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex, The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR)


This is Bestrophin-1 protein, from Human, contains 585 amino acids, is membrane-bound, locates in Cell membrane.

Forms calcium-sensitive chloride channels, Highly permeable to bicarbonate

Belongs to the anion channel-forming bestrophin (TC 1,A,46) family, Calcium-sensitive chloride channel subfamily


This is Small ribosomal subunit protein eS21 protein, from Fruit fly, contains 83 amino acids, is soluble, locates in Cytoplasm.

May be an associated component of the ribosome rather than a core structural subunit, May act as a translation initiation factor, Has a role in regulation of cell proliferation in the hematopoietic organs and the imaginal disks of larva

Belongs to the eukaryotic ribosomal protein eS21 family


This is Membrane metalloprotease ARASP, chloroplastic protein, from Mouse-ear cress, contains 447 amino acids, is membrane-bound, locates in Plastid.

Metalloprotease essential for chloroplast and plant development, May be involved in regulated intramembrane proteolysis (RIP)


This is Transcription factor AS1 protein, from Mouse-ear cress, contains 367 amino acids, locates in Nucleus.

Transcription factor required for normal cell differentiation, Positively regulates LATERAL ORGAN BOUNDARIES (LOB) within the shoot apex, and the class III HD-ZIP genes REV, PHB, and PHV, Interacts directly with ASYMMETRIC LEAVES 2 (LBD6/AS2) to repress the knox homeobox genes BP/KNAT1, KNAT2, and KNAT6 and the abaxial determinants ARF3/ETT, KAN2 and YAB5, May act in parallel with the RDR6-SGS3-AGO7 pathway, an endogenous RNA silencing pathway, to regulate the leaf morphogenesis (PubMed:11076771, PubMed:11140682, PubMed:11882937, PubMed:12750468, PubMed:16006579, PubMed:16699177, PubMed:17395603, PubMed:17559509, PubMed:23271976), Binds directly to KNAT1, KNAT2, and KNATM chromatin, regulating leaf development (PubMed:23271976), LBD6 is required for this binding (PubMed:23271976), Positive regulator of flowering that binds to the promoter of FT (PubMed:21950734), Regulates FT expression by forming a functional complex with CO (PubMed:21950734), Involved in leaf polarity establishment by functioning cooperatively with NUCL1 to repress abaxial genes ARF3, ARF4, KAN1, KAN2, YAB1 and YAB5, and the knox homeobox genes KNAT1, KNAT2, KNAT6, and STM to promote adaxial development in leaf primordia at shoot apical meristems at high temperatures (PubMed:27334696)


This is L-type lectin-domain containing receptor kinase IV.1 protein, from Mouse-ear cress, contains 675 amino acids, is membrane-bound, locates in Cell membrane.

In the N-terminal section; belongs to the leguminous lectin family


This is DNA-binding protein RHL1 protein, from Mouse-ear cress, contains 355 amino acids, locates in Nucleus.

Component of the DNA topoisomerase VI complex involved in chromatin organization and progression of endoreduplication cycles, Binds to DNA, Required for endoreduplication beyond 8C


This is Villin-3 protein, from Mouse-ear cress, contains 965 amino acids, is soluble, locates in Cytoplasm.

Binds actin and actin filament bundles in a Ca(2+)-insensitive manner, but severs actin filaments in a calcium-dependent manner, regardless of the presence or not of VLN1 (AC O81643), Acts redundantly with VLN2 (AC O81644) to generate thick actin filament bundles, to regulate directional organ growth (PubMed:22209875) and in sclerenchyma development (PubMed:22563899)


This is Protease Do-like 2, chloroplastic protein, from Mouse-ear cress, contains 607 amino acids, is membrane-bound, locates in Plastid.

Serine protease that performs the primary cleavage of the photodamaged D1 protein in plant photosystem II


This is Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 3 protein, from Mouse-ear cress, contains 219 amino acids, locates in Nucleus.

Probable transcription regulator that acts as a developmental regulator by promoting cell growth in response to light (By similarity), Required for the maintenance of the shoot apical meristem and for the formation of lateral organs, Promotes petal formation and growth, but may suppress organ differentiation in the boundary region

Belongs to the plant homeotic and developmental regulators ALOG protein family


This is Agamous-like MADS-box protein AGL19 protein, from Mouse-ear cress, contains 219 amino acids, locates in Nucleus.

Probable transcription factor that promotes flowering, especially in response to vernalization by short periods of cold, in an FLC-inpedendent manner


This is Protein EARLY FLOWERING 3 protein, from Mouse-ear cress, contains 695 amino acids, locates in Nucleus.

May be a transcription factor part of a circadian clock input pathway, Acts within a 'zeitnehmer' feedback loop and is involved in its own circadian regulation, Has no role in regulating circadian clock function in the dark, Part of a corepressor complex consisting of ELF4, ELF3, and LUX involved in the transcriptional regulation of APRR9, The activity of the protein may be decreased in long day conditions due to its interaction with phytochrome B (phyB), Can regulate the initiation of flowering independently of phyB, Also involved in responses to nematode parasitism, like the formation of the nematode feeding structure


This is DBIRD complex subunit ZNF326 protein, from Mouse, contains 580 amino acids, has 2 C2H2 AKAP95-type Zinc finger, is soluble, locates in Nucleus.

C2H2 AKAP95-type

C2H2 AKAP95-type

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (By similarity), May also play a role in neuronal differentiation, Able to bind DNA and activate expression in vitro


This is Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 protein, from Mouse, contains 863 amino acids, is membrane-bound, locates in Cell membrane.

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions, Contributes to the native pacemaker currents in heart (If) and in neurons (Ih), Can also transport ammonium in the distal nephron, Produces a large instantaneous current

Belongs to the potassium channel HCN family


This is Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 protein, from Mouse, contains 779 amino acids, is membrane-bound, locates in Cell membrane.

Hyperpolarization-activated potassium channel, May also facilitate the permeation of sodium ions


This is Interferon-induced transmembrane protein 5 protein, from Mouse, contains 134 amino acids, is membrane-bound, locates in Cell membrane.


This is Gamma-aminobutyric acid type B receptor subunit 2 protein, from Rat, contains 940 amino acids, is membrane-bound, locates in Cell membrane.

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872315, PubMed:9872317, PubMed:9872744), Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:9872317, PubMed:10658574), Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:9872315, PubMed:9872317, Ref,4, PubMed:10075644, PubMed:9872744, PubMed:10924501), Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:9872315, PubMed:9872317, PubMed:10457184, PubMed:9872744, PubMed:10924501), Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872317, PubMed:10457184, PubMed:9872744), Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872744, PubMed:10924501), Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity)

Belongs to the G-protein coupled receptor 3 family, GABA-B receptor subfamily


This is Glucosamine-6-phosphate isomerase 1 protein, from Mouse, contains 289 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway, Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P, At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis (By similarity), Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (By similarity), Seems to trigger calcium oscillations in mammalian eggs, These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity)

Belongs to the glucosamine/galactosamine-6-phosphate isomerase family


This is Legumain protein, from Mouse, contains 435 amino acids, locates in Lysosome/Vacuole.

Has a strict specificity for hydrolysis of asparaginyl bonds, Can also cleave aspartyl bonds slowly, especially under acidic conditions, May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system, Required for normal lysosomal protein degradation in renal proximal tubules, Required for normal degradation of internalized EGFR, Plays a role in the regulation of cell proliferation via its role in EGFR degradation


This is Sulfide:quinone oxidoreductase, mitochondrial protein, from Fission yeast, contains 459 amino acids, locates in Mitochondrion.

Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone


This is Ascus wall endo-1,3-alpha-glucanase protein, from Fission yeast, contains 433 amino acids, is soluble, locates in Cytoplasm.

Promotes the release of ascospores from asci by hydrolyzing 1,3-alpha-glucan in the ascus wall

Belongs to the glycosyl hydrolase 71 family


This is Versatile peroxidase VPL2 protein, from Boletus of the steppes, contains 361 amino acids, is soluble, locates in Extracellular.

A versatile ligninolytic peroxidase that combines the substrate specificity characteristics of the two other ligninolytic peroxidases, manganese peroxidase and lignin peroxidase

Belongs to the peroxidase family, Ligninase subfamily


This is Serine/threonine-protein kinase 10 protein, from Human, contains 968 amino acids, is membrane-bound, locates in Cell membrane.

Serine/threonine-protein kinase involved in regulation of lymphocyte migration, Phosphorylates MSN, and possibly PLK1, Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN, Acts as a negative regulator of MAP3K1/MEKK1, May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo

Belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily


This is UBX domain-containing protein 7 protein, from Human, contains 489 amino acids, locates in Nucleus.

Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates