This is E3 ubiquitin-protein ligase CBL-B protein, from Mouse, contains 982 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome, Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways, In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production, Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation, In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy, In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation, Slightly promotes SRC ubiquitination, May be involved in EGFR ubiquitination and internalization, May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3, In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (PubMed:29237719)


This is M-phase phosphoprotein 8 protein, from Mouse, contains 858 amino acids, locates in Nucleus.

Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression, Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene, Mediates down-regulation of CDH1 expression, Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark, Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression, The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed


This is Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 protein, from Mouse, contains 429 amino acids, is membrane-bound, locates in Cell membrane.

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells, Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition, Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins, May be involved in cell adhesion signaling


This is Hepatoma-derived growth factor-related protein 2 protein, from Mouse, contains 669 amino acids, locates in Nucleus.

Binds to non-condensed chromatin in the presence of HDGF


This is Acyl-coenzyme A synthetase ACSM3, mitochondrial protein, from Mouse, contains 580 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11470804), Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms (PubMed:11470804)

Belongs to the ATP-dependent AMP-binding enzyme family


This is Centrosomal protein of 63 kDa protein, from Mouse, contains 700 amino acids, is soluble, locates in Cytoplasm.

Required for normal spindle assembly (PubMed:24240477), Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity), Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (By similarity), Also recruits CDK1 to centrosomes (By similarity), Plays a role in DNA damage response (By similarity), Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity), Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (By similarity)


This is Thiamine thiazole synthase 2, chloroplastic protein, from Maize, contains 354 amino acids, locates in Plastid.

Involved in biosynthesis of the thiamine precursor thiazole, Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate, The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate, The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme, May have additional roles in adaptation to various stress conditions and in DNA damage tolerance


This is Probable mitochondrial-processing peptidase subunit beta, mitochondrial protein, from Mouse-ear cress, contains 531 amino acids, locates in Mitochondrion.

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation, The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase, The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol, In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c


This is Cytochrome b5 isoform E protein, from Mouse-ear cress, contains 134 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases, including fatty acid desaturases


This is Protein COLD-REGULATED 15A, chloroplastic protein, from Mouse-ear cress, contains 139 amino acids, is soluble, locates in Plastid.

Exhibits cryoprotective activity toward stromal substrates (e,g, LDH and rubisco) in chloroplasts and in protoplasts and confers freezing tolerance to plants in a CBF-dependent manner (PubMed:1567390, PubMed:11038526, PubMed:9826741, PubMed:17384167, PubMed:18540080, PubMed:19563440), Protectant against various stresses (e,g, cold, drought and heat stress) by preventing protein aggregation (e,g, LDH) and attenuating enzyme inactivation (PubMed:18540080), Influences the intrinsic curvature of the inner membrane of the chloroplast envelope, and modulates the freeze-induced lamellar-to-hexagonal II phase transitions that occur in regions where the plasma membrane is brought into close apposition with the chloroplast envelope during freeze-induced osmotic contraction (PubMed:9826741), Mediates a shift in the melting curves of phospholipids-containing membranes to lower temperatures (PubMed:20510170), Involved in the regulation of leaf senescence by abscisic acid (ABA) in a VNI2-dependent manner (PubMed:21673078)


This is HMG-Y-related protein A protein, from Mouse-ear cress, contains 204 amino acids, locates in Nucleus.

Binds A/T-rich DNA with a highly dynamic distribution into the nucleus


This is Cysteine synthase, mitochondrial protein, from Mouse-ear cress, contains 430 amino acids, locates in Mitochondrion.

Acts as a cysteine synthase, Plays a role in the sulfide detoxification in mitochondria

Belongs to the cysteine synthase/cystathionine beta-synthase family


This is Sodium-coupled monocarboxylate transporter 2 protein, from Mouse, contains 619 amino acids, is membrane-bound, locates in Cell membrane.

Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter, Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate, May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine, May play also a role in monocarboxylates transport in the retina, Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate

Belongs to the sodium:solute symporter (SSF) (TC 2,A,21) family


This is Transcription factor MYB59 protein, from Mouse-ear cress, contains 235 amino acids, locates in Nucleus.


This is Exo-beta-D-glucosaminidase protein, from Trichoderma reesei, contains 892 amino acids, is soluble, locates in Extracellular.

Hydrolyzes chitosan and chitooligosaccharides with retention of anomeric configuration, Has no activity against beta-D-galactoside, beta-D-glucuronide, beta-D-mannoside, chitin, glycol chitosan, cellulose, N,N'-diacetylchitibiose and pNP-GlcNAc

Belongs to the glycosyl hydrolase 2 family


This is Mitochondrial-processing peptidase subunit beta protein, from Social amoeba, contains 469 amino acids, is membrane-bound, locates in Mitochondrion.

Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable), Preferentially, cleaves after an arginine at position P2 (By similarity), Plays an essential role in mitochondrial biogenesis (PubMed:18603769)


This is Complement C1q and tumor necrosis factor-related protein 9 protein, from Mouse, contains 333 amino acids, is soluble, locates in Extracellular.

Probable adipokine, Activates AMPK, AKT, and p44/42 MAPK signaling pathways


This is bZIP transcription factor 16 protein, from Mouse-ear cress, contains 409 amino acids, locates in Nucleus.

Transcriptional activator that binds to the G-box motif (5'-CACGTG-3') and other cis-acting elements with 5'-ACGT-3' core, such as Hex, C-box and as-1 motifs, Possesses high binding affinity to G-box, much lower affinity to Hex and C-box, and little affinity to as-1 element (PubMed:18315949), G-box and G-box-like motifs are cis-acting elements defined in promoters of certain plant genes which are regulated by such diverse stimuli as light-induction or hormone control (Probable), Binds to the G-box motif 5'-CACGTG-3' of LHCB2,4 (At3g27690) promoter, May act as transcriptional repressor in light-regulated expression of LHCB2,4, Binds DNA as monomer, DNA-binding activity is redox-dependent (PubMed:22718771)


This is Non-structural maintenance of chromosomes element 1 protein, from Fission yeast, contains 232 amino acids, has 1 RING-type; atypical Zinc finger, locates in Nucleus.

RING-type; atypical

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage, Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks, Plays a critical role in meiosis


This is Coiled-coil domain-containing protein 92 protein, from Human, contains 331 amino acids, is soluble, locates in Cytoplasm.

Interferon-stimulated protein that plays a role in innate immunity, Strongly inhibits ebolavirus transcription and replication, Forms a complex with viral RNA-bound nucleocapsid NP and thereby prevents the transport of NP to the cell surface


This is Transmembrane 4 L6 family member 20 protein, from Human, contains 229 amino acids, is membrane-bound, locates in Cell membrane.

Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293), In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293), Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293)


This is FAST kinase domain-containing protein 1, mitochondrial protein, from Human, contains 847 amino acids, locates in Mitochondrion.

Involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity


This is Basic-leucine zipper transcription factor B protein, from Social amoeba, contains 602 amino acids, locates in Nucleus.

Transcriptional regulator involved in DIF-1 signaling, DIF-1 (Differentiation Inducing Factor-1) is a signal molecule involved in the differentiation of pstO (prestalk-O) cells (By similarity), May be a direct activator of ecmA


This is P2X receptor E protein, from Social amoeba, contains 388 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling, Not required for the purinergic response to extracellular nucleotides, Not essential for osmoregulation, Inward currents evoked by intracellular ATP, ATP analog beta, gamma-imido-ATP is a weak partial agonist of p2xE, Exclusively selective for ATP over other nucleotides, Insensitive to copper and P2 receptor antagonists PPADS and suramin but strongly inhibited by sodium ions, More permeable to ammonium than either sodium or potassium ions and less permeable to choline, Permeable to calcium ions, but not chloride


This is Vacuole membrane protein 1 homolog protein, from Social amoeba, contains 403 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (By similarity), Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted (By similarity), In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:18550798)


This is Protein phosphatase 2A scaffold subunit protein, from Social amoeba, contains 584 amino acids, is soluble, locates in Cytoplasm.

Scaffolding molecule which may coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:20493808), Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay (PubMed:20493808), The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway (PubMed:20493808)

Belongs to the phosphatase 2A regulatory subunit A family


This is UDP-galactose:fucoside alpha-3-galactosyltransferase protein, from Social amoeba, contains 648 amino acids, is soluble, locates in Cytoplasm.

Specifically catalyzes the transfer of a galactosyl residue to the hydroxyproline-linked saccharide on Skp1 protein (fpaA/fpaB), Catalyzes the formation of a Gal-alpha-1,3-Fuc linkage, leading to Gal-Fuc-Gal-GlcNAc-HyPro143-Skp1

Belongs to the glycosyltransferase 77 family


This is Phosphorelay intermediate protein rdeA protein, from Social amoeba, contains 254 amino acids, is soluble, locates in Cytoplasm.

Phosphorelay protein that supplies phosphate to regA or accepts phosphate from regA; depending on the relative concentration of the phosphodonor proteins, In vitro, acts as a substrate for cheA (bacterial kinase), Plays a role in the development, ypd1 (yeast) can complement rdeA defect


This is P2X receptor B protein, from Social amoeba, contains 369 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling, Not required for the purinergic response to extracellular nucleotides, Not essential for osmoregulation, Inward currents are evoked by intracellular ATP and ATP analogs, Insensitive to the P2 receptor antagonists PPADS and suramin, and also copper ions, Inhibited by sodium ions, Permeable to chloride ions


This is Laccase-1 protein, from Filobasidiella neoformans, contains 624 amino acids, is soluble, locates in Extracellular.

Laccase that catalyzes the oxidation of certain aromatic compounds, including L-dopa, to quinones, which then polymerize to melanin (PubMed:1100669, PubMed:6807845, PubMed:6804444, PubMed:8760791), Able to oxidize a wide variety of aromatic diphenol and diamino groups in the ortho, meta, and para positions but not monophenolic groups such as in phenol, tyramine, or tyrosine (PubMed:8300520), Plays an important role in virulence (PubMed:8760791), Plays a role in dissemination to extrapulmonary sites but is not involved in pulmonary growth or in elicitation of cellular immune responses in the lung (PubMed:14977977)

Belongs to the multicopper oxidase family


This is Zinc finger protein 385B protein, from Human, contains 471 amino acids, has 4 Matrin-type Zinc finger, locates in Nucleus.

Matrin-type

Matrin-type

Matrin-type

Matrin-type

May play a role in p53/TP53-mediated apoptosis


This is Thyroid hormone receptor-associated protein 3 protein, from Mouse, contains 951 amino acids, is soluble, locates in Nucleus.

Involved in pre-mRNA splicing, Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC), Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition, May be involved in nuclear mRNA decay, Involved in regulation of signal-induced alternative splicing, During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells, Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA, Involved in response to DNA damage, Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex, Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit, Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand, May play a role in the terminal stage of adipocyte differentiation, Plays a role in the positive regulation of the circadian clock, Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798)


This is Glutamine synthetase cytosolic isozyme 1-1 protein, from Mouse-ear cress, contains 356 amino acids, is soluble, locates in Cytoplasm.

High-affinity glutamine synthetase which catalyzes the synthesis of glutamine from ammonium and glutamate (PubMed:14757761), May contribute to the homeostatic control of glutamine synthesis in roots

Belongs to the glutamine synthetase family


This is Ubiquinol oxidase 4, chloroplastic/chromoplastic protein, from Mouse-ear cress, contains 351 amino acids, is membrane-bound, locates in Plastid.

Acts early in chloroplast biogenesis as a component of a redox chain responsible for phytoene desaturation, Prevents the generation of toxic oxygen radicals and photooxidation of the nascent photosynthetic apparatus, Involved in the differentiation of multiple plastid types, including chloroplasts, amyloplasts, and etioplasts, Might participate in the chloroplast respiratory chain

Belongs to the alternative oxidase family


This is Protein arginine N-methyltransferase 7 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 390 amino acids, is soluble, locates in Cytoplasm.

Arginine methyltransferase that specifically catalyzes the formation of omega-N monomethylarginine (MMA), Has activity toward multiple substrates in vitro, Able to mediate the arginine methylation of histones and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo

Belongs to the class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family, PRMT7 subfamily


This is PAN2-PAN3 deadenylation complex subunit PAN3 protein, from Human, contains 887 amino acids, has 1 C3H1-type Zinc finger, is soluble, locates in Cytoplasm.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP), PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1, PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins

Belongs to the protein kinase superfamily, PAN3 family


This is Transcription factor E2F8 protein, from Mouse, contains 860 amino acids, locates in Nucleus.

Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells, Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3', Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis, Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3), Required for placental development by promoting polyploidization of trophoblast giant cells, Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene


This is DDB1- and CUL4-associated factor 6 protein, from Human, contains 860 amino acids, locates in Nucleus.

Ligand-dependent coactivator of nuclear receptors, Enhance transcriptional activity of the nuclear receptors NR3C1 and AR, May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex


This is REST corepressor protein, from Fruit fly, contains 590 amino acids, locates in Nucleus.

Essential component of a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells, The BHC complex is recruited by Ttk88 and probably acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier, May serve as a molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval


This is Cell wall mannoprotein PIR1 protein, from Yeast, contains 385 amino acids, is soluble, locates in Extracellular.

Component of the outer cell wall layer required for stability of the cell wall and specifically for cell wall rigidity


This is Protein BIG1 protein, from Yeast, contains 322 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for normal beta-1,6-glucan synthesis, for hyphal morphogenesis, adhesion and virulence


This is Histone deacetylase HDA1 protein, from Yeast, contains 833 amino acids, locates in Nucleus.

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Histone deacetylases act via the formation of large multiprotein complexes, Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes, Plays a key role in the regulation of filamentous growth and virulence, Involved in the switch between two heritable states, the white and opaque states, These two cell types differ in many characteristics, including cell structure, mating competence, and virulence, Each state is heritable for many generations, and switching between states occurs stochastically at low frequency

Belongs to the histone deacetylase family, HD type 2 subfamily


This is Transcription factor RBF1 protein, from Yeast, contains 534 amino acids, locates in Nucleus.

Transcriptional activator that binds to the RPG box and to telomeres, Involved in the regulation of the transition between yeast and filamentous forms and plays a role in virulence, Induces expression of HWP1, a major hyphal cell protein and virulence factor


This is Diamine acetyltransferase protein, from Cryptosporidium parvum (strain Iowa II), contains 152 amino acids, is soluble, locates in Cytoplasm.

Enzyme which catalyzes the acetylation of polyamines, Displays higher substrate specificity for spermine than for spermidine, May function to acetylate host-derived polyamines, thus alleviating the necessity for de novo synthesis of these molecules


This is Trans-2-enoyl-CoA reductase protein, from Euglena gracilis, contains 539 amino acids, locates in Mitochondrion.

Catalyzes reduction of trans-2-enoyl-CoA to acyl-CoA, an important step in the fatty acid biosynthesis pathway, which is performed in mitochondria under anaerobiosis, Preferably catalyzes the reduction of short chain length substrates such as crotonyl-CoA ((2E)-butenoyl-CoA) and (2E)-hexenoyl-CoA, Can use both NADH and NADPH as electron donor, with 2-3-fold higher specific activities for NADH relative to NADPH, Originally thought to contribute to wax ester production under anaerobic conditions (PubMed:15569691), Later shown to be dispensable for wax ester production under anaerobic conditions, but involved in the greening process (chlorophyll synthesis and/or chloroplast development) (PubMed:30650145)


This is Major urinary protein 20 protein, from Mouse, contains 181 amino acids, is soluble, locates in Extracellular.

Male pheromone which stimulates female sexual attraction to male urinary scent and promotes a strong learned attraction to the airborne urinary odor of an individual male (PubMed:20525243, PubMed:31996852), Promotes spatial learning by rapidly conditioning preference for its remembered location among females and competitor males so that animals prefer to spend time in the site even when scent is absent (PubMed:23239735), In addition to promoting a rapid attraction response, also elicits ultrasonic vocalizations and urinary scent marking in females which do not occur immediately after exposure (PubMed:31996852), Stimulates hippocampal neurogenesis and cell proliferation in the subventricular zone in females (PubMed:25972792), Promotes male aggressive behavior (PubMed:18064011), Response to Mup20 is mediated by a neural circuit extending from the accessory olfactory bulb to a subset of nitric oxidase synthase-expressing neurons in the medial amygdala (PubMed:31996852), As well as acting as a pheromone itself, binds most of the male pheromone, 2-sec-butyl-4,5-dihydrothiazole, in urine and is responsible for its slow release from scent marks (PubMed:15934926, PubMed:25279835)

Belongs to the calycin superfamily, Lipocalin family


This is Extracellular matrix protein 2 protein, from Mouse, contains 670 amino acids, is soluble, locates in Extracellular.

Promotes matrix assembly and cell adhesiveness

Belongs to the small leucine-rich proteoglycan (SLRP) family, SLRP class I subfamily


This is N-acetyltransferase ESCO1 protein, from Human, contains 840 amino acids, has 1 CCHH-type Zinc finger, locates in Nucleus.

CCHH-type

Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053), Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together, In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase, Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053)

Belongs to the acetyltransferase family, ECO subfamily


This is Maternal DNA replication licensing factor mcm6 protein, from African clawed frog, contains 821 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development


This is Protein FAM76B protein, from Human, contains 339 amino acids, locates in Nucleus.


This is Transcription initiation factor TFIID subunit 3 protein, from Mouse, contains 932 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity), TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity), The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (By similarity), The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (By similarity), TAF3 forms the TFIID-A module together with TAF5 and TBP (By similarity), Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:17704303), The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:17704303)


This is Alanine--tRNA ligase, mitochondrial protein, from Human, contains 985 amino acids, locates in Mitochondrion.

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala), Also edits incorrectly charged tRNA(Ala) via its editing domain

Belongs to the class-II aminoacyl-tRNA synthetase family


This is EF-hand domain-containing protein 1 protein, from Human, contains 640 amino acids, is soluble, locates in Cytoplasm.

Microtubule-associated protein which regulates cell division and neuronal migration during cortical development, Necessary for mitotic spindle organization (PubMed:19734894, PubMed:28370826), Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (PubMed:22926142), May enhance calcium influx through CACNA1E and stimulate programmed cell death (PubMed:15258581), Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity)


This is Polyserase-2 protein, from Human, contains 855 amino acids, is soluble, locates in Extracellular.

Serine protease, Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC, Has a preference for substrates with an Arg instead of a Lys residue in position P1


This is Fatty acid 2-hydroxylase protein, from Mouse, contains 372 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15658937, PubMed:16998236, PubMed:22517924), FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (PubMed:22517924), Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (PubMed:15658937, PubMed:18815260), Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (By similarity), Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (PubMed:21628453), Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (PubMed:22517924)

Belongs to the sterol desaturase family, SCS7 subfamily


This is Polyprenol reductase protein, from Rat, contains 330 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol (PubMed:8486680), Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (PubMed:8486680), Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (PubMed:8486680), Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity)

Belongs to the steroid 5-alpha reductase family, Polyprenol reductase subfamily


This is Two-component response regulator ORR22 protein, from Rice, contains 696 amino acids, locates in Nucleus.

Transcriptional activator that binds specific DNA sequence, Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system, Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes, May directly activate some type-A response regulators in response to cytokinins (By similarity), Functions as a response regulator in response to cytokinins (PubMed:22383541)

Belongs to the ARR family, Type-B subfamily


This is Adenosine deaminase domain-containing protein 1 protein, from Mouse, contains 619 amino acids, locates in Nucleus.

Required for male fertility and normal male germ cell differentiation (PubMed:32665638), Plays a role in spermatogenesis (PubMed:15649457), Binds to RNA but not to DNA (PubMed:15649457)


This is Mitochondrial cardiolipin hydrolase protein, from Mouse, contains 221 amino acids, has 1 C3H1-type; atypical Zinc finger, is membrane-bound, locates in Mitochondrion.

C3H1-type; atypical

Presents phospholipase and nuclease activities, depending on the different physiological conditions, Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity, Plays a key role in mitochondrial fusion and fission via its phospholipase activity, In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid, Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission, Both Lipin and DAG regulate mitochondrial dynamics and membrane fusion/fission, important processes for adapting mitochondrial metabolism to changes in cell physiology, Mitochondrial fusion enables cells to cope with the increased nucleotide demand during DNA synthesis (By similarity), Mitochondrial function and dynamics are closely associated with biological processes such as cell growth, proliferation, and differentiation (PubMed:21397848), Mediator of MYC activity, promotes mitochondrial fusion and activates AMPK which in turn inhibits YAP/TAZ, thereby inducing cell growth and proliferation (PubMed:26678338), The endonuclease activity plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis (PubMed:21397847, PubMed:21397848), Implicated in spermatogenesis and sperm fertility in testicular germ cells, its single strand-specific nuclease activity is critical for the biogenesis/maturation of PIWI-interacting RNA (piRNA) (PubMed:21397847, PubMed:23064230, PubMed:23064227), MOV10L1 selectively binds to piRNA precursors and funnels them to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins (PubMed:25762440), Cleaves either DNA or RNA substrates with similar affinity, producing a 5' phosphate end, in this way it participates in the processing of primary piRNA transcripts, piRNAs provide essential protection against the activity of mobile genetic elements, piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (PubMed:23064230, PubMed:23064227), PA may act as signaling molecule in the recognition/transport of the precursor RNAs of primary piRNAs (PubMed:21397847), Interacts with tesmin in testes, suggesting a role in spermatogenesis via association with its interacting partner (PubMed:33783608)

Belongs to the phospholipase D family, MitoPLD/Zucchini subfamily


This is KN motif and ankyrin repeat domain-containing protein 4 protein, from Human, contains 995 amino acids, is soluble, locates in Cytoplasm.

May be involved in the control of cytoskeleton formation by regulating actin polymerization


This is ATPase family AAA domain-containing protein 3B protein, from Human, contains 648 amino acids, is membrane-bound, locates in Mitochondrion.

May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network, may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes


This is DEP domain-containing protein 1A protein, from Human, contains 811 amino acids, locates in Nucleus.

May be involved in transcriptional regulation as a transcriptional corepressor, The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells


This is Arginine-hydroxylase NDUFAF5, mitochondrial protein, from Human, contains 345 amino acids, is membrane-bound, locates in Mitochondrion.

Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages (PubMed:18940309, PubMed:27226634), Acts by mediating hydroxylation of 'Arg-111' of NDUFS7 (PubMed:27226634), May also have methyltransferase activity (Probable)

Belongs to the methyltransferase superfamily


This is Translocator protein 2 protein, from Human, contains 170 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Cholesterol-binding protein involved in the redistribution of cholesterol from lipid droplets to the endoplasmic reticulum (PubMed:19729679), Required to meet cholesterol demands during erythropoietic differentiation (PubMed:19729679), May play a role in transport processes at the plasma membrane of erythrocytes, including regulating VDAC-mediated ATP export, and import of the heme precursors protoporphyrin IX and 5-aminolevulinic acid (PubMed:27641616, PubMed:30061676, PubMed:31989647)


This is MICOS complex subunit MIC10 protein, from Human, contains 78 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Belongs to the MICOS complex subunit Mic10 family


This is Cytoplasmic dynein 2 intermediate chain 2 protein, from Mouse, contains 537 amino acids, is soluble, locates in Cytoplasm.

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways, Inhibits the MAP3K7-induced NF-kappa-B activation pathway, Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation

Belongs to the dynein light intermediate chain family


This is Complex III assembly factor LYRM7 protein, from Human, contains 104 amino acids, is soluble, locates in Mitochondrion.

Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex, Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane


This is Mitochondrial amidoxime-reducing component 1 protein, from Human, contains 337 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129), As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771), May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045), Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045, PubMed:19053771)


This is Zinc finger protein Gfi-1b protein, from Human, contains 330 amino acids, has 6 C2H2-type Zinc finger, locates in Nucleus.

Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages, Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation, Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways, Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate, Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells, Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells, Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction, Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression, Alters histone methylation by recruiting histone methyltransferase to target genes promoters, Plays a role in heterochromatin formation


This is Transcription initiation factor TFIID subunit 3 protein, from Human, contains 929 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473), TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473), The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473), The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473), TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473), Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666), The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666)


This is Interleukin-23 receptor protein, from Human, contains 629 amino acids, is membrane-bound, locates in Cell membrane.

Associates with IL12RB1 to form the interleukin-23 receptor, Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade, IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues, IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis

Belongs to the type I cytokine receptor family, Type 2 subfamily


This is ADP-ribosylation factor GTPase-activating protein AGD3 protein, from Mouse-ear cress, contains 827 amino acids, has 1 C4-type Zinc finger, locates in Golgi apparatus.

GTPase-activating protein (GAP) for ADP ribosylation factor (ARF), Involved in the spatial control of provascular differentiation, Required for the formation of the normal pattern of continuous secondary veins, Involved in auxin signaling but not in polar auxin transport or in auxin responses, Required for PIN1 internalization in roots


This is Autocrine proliferation repressor protein A protein, from Social amoeba, contains 494 amino acids, is soluble, locates in Extracellular.

Inhibitor that slows proliferation of secreting cells (also known as chalone), May function by binding to cell surface receptors, Requires cfaD for activity, Overexpression slows proliferation


This is AP2-like ethylene-responsive transcription factor PLT2 protein, from Mouse-ear cress, contains 568 amino acids, locates in Nucleus.

Probably acts as a transcriptional activator, Binds to the GCC-box pathogenesis-related promoter element, May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity), Master regulator of basal/root fate, Essential for root quiescent center (QC) and columella specification, stem cell activity, as well as for establishment of the stem cell niche during embryogenesis, Modulates the root polar auxin transport by regulating the distribution of PIN genes, Essential role in respecifying pattern and polarity in damaged roots, Direct target of the transcriptional corepressor TPL, Expression levels and patterns regulated post-transcriptionally by root meristem growth factors (RGFs)

Belongs to the AP2/ERF transcription factor family, AP2 subfamily


This is Proton-coupled zinc antiporter SLC30A5 protein, from Chicken, contains 770 amino acids, is membrane-bound, locates in Golgi apparatus.

Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15525635), By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15525635)

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2,A,4) family, SLC30A subfamily


This is Lymphocyte-specific helicase protein, from Mouse, contains 821 amino acids, locates in Nucleus.

Plays an essential role in normal development and survival, Involved in regulation of the expansion or survival of lymphoid cells, Required for de novo or maintenance DNA methylation, May control silencing of the imprinted CDKN1C gene through DNA methylation, May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis

Belongs to the SNF2/RAD54 helicase family


This is Homeobox protein Meis1 protein, from Mouse, contains 390 amino acids, locates in Nucleus.

Acts as a transcriptional regulator of PAX6, Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2, Required for hematopoiesis, megakaryocyte lineage development and vascular patterning, May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias

Belongs to the TALE/MEIS homeobox family


This is WW domain-binding protein 4 protein, from Mouse, contains 376 amino acids, has 1 Matrin-type Zinc finger, locates in Nucleus.

Matrin-type

Involved in pre-mRNA splicing as a component of the spliceosome, May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex


This is Protein phosphatase 1G protein, from Mouse, contains 542 amino acids, is membrane-bound, locates in Nucleus.

May be involved in regulation of cell cycle


This is 45 kDa calcium-binding protein protein, from Mouse, contains 361 amino acids, is soluble, locates in Golgi apparatus.

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment


This is Neuroblastoma suppressor of tumorigenicity 1 protein, from Mouse, contains 178 amino acids, is soluble, locates in Extracellular.

Possible candidate as a tumor suppressor gene of neuroblastoma, May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process


This is Glucagon receptor protein, from Mouse, contains 485 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis, Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis, Plays an important role in mediating the responses to fasting, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Promotes activation of adenylate cyclase, Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system

Belongs to the G-protein coupled receptor 2 family


This is Homeobox protein SIX3 protein, from Mouse, contains 333 amino acids, locates in Nucleus.

Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes, During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon (PubMed:18094027), Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression (PubMed:18775421), In addition, Six3 activity is required for the formation of the telencephalon, During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration (PubMed:22071110), Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2 (PubMed:17576749), During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm (PubMed:17066077), In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation (PubMed:12072567), Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory (PubMed:20890044), Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner, Furthermore, during eye development regulates several genes expression, Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element (PubMed:11139622), Directly activates RHO transcription, or cooperates with CRX or NRL (PubMed:17666527), Six3 functions also in the formation of the proximodistal axis of the optic cup (PubMed:12163408), and promotes the formation of optic vesicles-like structures (PubMed:11458394), During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (PubMed:18694563), Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway (By similarity)

Belongs to the SIX/Sine oculis homeobox family


This is Neurogenic differentiation factor 2 protein, from Mouse, contains 383 amino acids, locates in Nucleus.

Transcriptional regulator implicated in neuronal determination, Mediates calcium-dependent transcription activation by binding to E box-containing promoter, Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons, Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression, Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex, Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis, Associates with chromatin to the DPYSL3 E box-containing promoter


This is Solute carrier family 22 member 1 protein, from Rat, contains 556 amino acids, is membrane-bound, locates in Cell membrane.

Functional isoform capable of transporting TEA

Belongs to the major facilitator (TC 2,A,1) superfamily, Organic cation transporter (TC 2,A,1,19) family


This is POU domain, class 3, transcription factor 3 protein, from Rat, contains 497 amino acids, locates in Nucleus.

Transcription factor that acts synergistically with SOX11 and SOX4, Plays a role in neuronal development, Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity)

Belongs to the POU transcription factor family, Class-3 subfamily


This is Synaptonemal complex protein 3 protein, from Rat, contains 257 amino acids, locates in Nucleus.

Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:8289794, PubMed:9933407), Required for centromere pairing during meiosis in male germ cells, Required for normal meiosis during spermatogenesis and male fertility, Plays a lesser role in female fertility, Required for efficient phosphorylation of HORMAD1 and HORMAD2


This is Dihydroorotate dehydrogenase (quinone), mitochondrial protein, from Rat, contains 395 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor, Required for UMP biosynthesis via de novo pathway

Belongs to the dihydroorotate dehydrogenase family, Type 2 subfamily


This is PAN2-PAN3 deadenylation complex subunit Pan3 protein, from Mouse, contains 837 amino acids, has 1 C3H1-type Zinc finger, is soluble, locates in Cytoplasm.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP), PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1, PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins

Belongs to the protein kinase superfamily, PAN3 family


This is Sclerostin domain-containing protein 1 protein, from Rat, contains 206 amino acids, is soluble, locates in Extracellular.

Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity), May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction, Enhances Wnt signaling and inhibits TGF-beta signaling


This is Deleted in azoospermia-like protein, from Mouse, contains 298 amino acids, is soluble, locates in Cytoplasm.

RNA-binding protein, which is essential for gametogenesis in both males and females, Plays a central role during spermatogenesis, Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts


This is Carboxypeptidase Z protein, from Human, contains 652 amino acids, is soluble, locates in Extracellular.

Cleaves substrates with C-terminal arginine residues, Probably modulates the Wnt signaling pathway, by cleaving some undefined protein, May play a role in cleavage during prohormone processing


This is Cyclin-dependent kinase inhibitor 1 protein, from Mouse-ear cress, contains 191 amino acids, is soluble, locates in Nucleus.

Binds and inhibits CYCD2-1/CDKA-1 kinase complex activity, Regulates cell division which is crucial for plant growth, development and morphogenesis, Functions in turning cells from a mitotic to an endoreplicating cell cycle mode, Acts cell- and non-cell-autonomously to regulate endoreduplication by allowing S phase progression, but blocking entry into mitosis, Keeps on the one hand the plant cell cycle locally controlled, and on the other hand provides a possibility of linking cell cycle control in single cells with the supracellular organization of a tissue or an organ, May target specifically CDKA-1

Belongs to the CDI family, ICK/KRP subfamily


This is E3 SUMO-protein ligase SIZ1 protein, from Mouse-ear cress, contains 884 amino acids, has 1 PHD-type Zinc finger, has 1 SP-RING-type Zinc finger, locates in Nucleus.

PHD-type

SP-RING-type

E3 SUMO protein ligase involved in regulation processes, Mediates SUMO/ attachment to PHR1, a MYB transcriptional activator controlling the phosphate deficiency responses (PubMed:15894620), Functions as an upstream negative regulator of salicylic acid (SA) accumulation and subsequent SA-mediated systemic acquired resistance (SAR) signaling, Probably not involved in jasmonic acid (JA)-mediated defense response, Participates in abiotic stress-induced sumoylation, Controls heat shock-induced SUMO1 and SUMO2 conjugation and facilitates basal thermotolerance, Involved in freezing tolerance by mediating sumoylation of ICE1, a transcription activator of the cold signaling regulator CBF3/DREB1A, Acts as positive regulator of drought stress tolerance, Acts as floral repressor that promotes FLC expression by repressing FLD activity through sumoylation, Acts as negative regulator of abscisic acid (ABA) signaling through ABI5 sumoylation, Mediates sumoylation of SCE1, GTE3 and GTE5, Functions as negative regulator of SnRK1 signaling through sumoylation of several components of the SnRK1 complex (PubMed:26662259)


This is Protein GAMETE EXPRESSED 1 protein, from Mouse-ear cress, contains 593 amino acids, is membrane-bound, locates in Cell membrane.

Has a dual function during gametophyte development and early embryogenesis, Required for correct pollen maturation


This is U3 small nucleolar RNA-associated protein 25 homolog protein, from Human, contains 756 amino acids, locates in Nucleus.

Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity), Essential for embryonic development in part through the regulation of p53 pathway, Controls the expansion growth of digestive organs and liver (PubMed:25007945, PubMed:27657329, PubMed:23357851), Also involved in the sympathetic neuronal development (By similarity), Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329)


This is HAUS augmin-like complex subunit 3 protein, from Human, contains 603 amino acids, is soluble, locates in Cytoplasm.

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex


This is Nuclear apoptosis-inducing factor 1 protein, from Human, contains 327 amino acids, locates in Nucleus.


This is Zinc finger protein PLAG1 protein, from Human, contains 500 amino acids, has 7 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed, Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction, Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas, Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood, Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Telomeric DNA-binding factor trf1 protein, from Fission yeast, contains 485 amino acids, locates in Nucleus.

Binds the telomeric double-stranded TTACAGG repeat and regulates telomere length


This is L-amino-acid oxidase protein, from California sea hare, contains 535 amino acids, is soluble, locates in Extracellular.

Catalyzes the oxidative deamination of positively charged L-amino acids L-Lys and L-Arg and, much less efficiently, of amino acids L-His and L-Tyr, Has antimicrobial activity, Inhibits growth of Gram-negative bacteria E,coli strain MC4100 (MIC=0,62 ug/ml), E,coli strain C921-b2, S,typhimurium strain AA 140 (MIC=0,62 ug/ml), P,aeruginosa strain PAO1 (MIC=0,31 ug/ml) and V,harveyi strain BB170 (MIC=0,25 ug/ml), Inhibits growth of Gram-positive bacteria S,aureus strain 6835 (MIC=0,31 ug/ml), S,pyogenes strain NZ131 (MIC=0,62 ug/ml), B,subtilis strain 168 (MIC=2,50 ug/ml) and B,subtilis strain WB600 (MIC=2,50 ug/ml), The antibacterial effect can be bacteriostatic, mediated mostly by H(2)O(2), as well as bactericidal, The latter appears to be due to unstable intermediates generated from alpha-keto-epsilon-aminocaproic acid, an intermediate of escapin-deaminated L-Lys, and H(2)O(2), The bactericidal effect is stronger at lower pH levels, Intermediates generated from L-Arg have no bactericidal effect, Inhibits growth of yeast species S,cerevisiae strain BY4761 (MIC=5,0 ug/ml) and C,krusei (MIC=5,0 ug/ml), Inhibits growth of C,sphaerospermum in a lysine-dependent manner, As components of ink, products from escapin's enzymatic activity may play a role in deterring eukaryotic predators

Belongs to the flavin monoamine oxidase family


This is Ethylene-responsive transcription factor ERF086 protein, from Mouse-ear cress, contains 348 amino acids, locates in Nucleus.

Probably acts as a transcriptional activator, May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity), Involved in the control of cell division patterns during the early lateral root primordium development, Acts downstream of auxin signaling (PubMed:17630277), Regulated by ARF7 and ARF19 in response to auxin, Co-acts with LBD16 and LBD18 to control lateral root development (PubMed:23749813), Involved in the determination of floral meristem identity and suppression of bract growth, Required for proper conversion of secondary inflorescences to flowers, Acts together with NPR5/BOP2 and NPR6/BOP1 to promote expression of LFY and AP1, two central regulators of floral meristem identity (PubMed:19482972)

Belongs to the AP2/ERF transcription factor family, ERF subfamily


This is Mitochondrial adenyl nucleotide antiporter SLC25A25 protein, from Human, contains 469 amino acids, is membrane-bound, locates in Mitochondrion.

Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane, Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it could have a broader specificity for adenyl nucleotides, By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Beta-1,4-N-acetylgalactosaminyltransferase 3 protein, from Human, contains 998 amino acids, is membrane-bound, locates in Golgi apparatus.

Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans, Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa

Belongs to the chondroitin N-acetylgalactosaminyltransferase family


This is Protein XRI1 protein, from Mouse-ear cress, contains 300 amino acids, locates in Nucleus.

Required for mitotic division of the generative cell nucleus and the development of mature tricellular pollen grains, and for male and female meiosis


This is Bifunctional phosphatase IMPL2, chloroplastic protein, from Mouse-ear cress, contains 346 amino acids, locates in Plastid.

Phosphatase required for histidine production, Acts also on L-galactose 1-phosphate (L-Gal 1-P), D-myoinositol 3-phosphate (D-Ins 3-P) and D-myoinositol 1-phosphate (D-Ins 1-P)

Belongs to the inositol monophosphatase superfamily


This is Protein DAMAGED DNA-BINDING 2 protein, from Mouse-ear cress, contains 557 amino acids, has 1 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type

May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex including DDB1A and CUL4 (By similarity), Required for DNA repair, Binds to DDB1A to form the UV-damaged DNA-binding protein complex (the UV-DDB complex), The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:18551167), Involved in UV-B tolerance and genome integrity, In association with ATCSA-1, is necessary for repair of UV-B-induced DNA lesions (PubMed:20128879)

Belongs to the WD repeat DDB2/WDR76 family


This is Protein POLAR LOCALIZATION DURING ASYMMETRIC DIVISION AND REDISTRIBUTION protein, from Mouse-ear cress, contains 344 amino acids, is soluble, locates in Cytoplasm.

Regulates asymmetric cell division (ACD), especially in stomatal-lineage cells (PubMed:21963668), Acts as a stomatal lineage scaffold which regulates subcellular localization and transient polarization of kinases (e,g, ASK7/BIN2 and ASK3/SK12) involved in ACD in a BASL-dependent manner (PubMed:30429609), Promotes the differentiation of both pavement cells and stomata (PubMed:30429609)


This is Homeobox protein NANOGP8 protein, from Human, contains 305 amino acids, locates in Nucleus.

May act as a transcription regulator (By similarity), When overexpressed, promotes entry of cells into S phase and cell proliferation


This is Mitochondrial adenyl nucleotide antiporter SLC25A24 protein, from Human, contains 477 amino acids, is membrane-bound, locates in Mitochondrion.

Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane, Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter, By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways (PubMed:15123600, PubMed:22015608), In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600), May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates (PubMed:22015608, PubMed:29100093)


This is Melanoregulin protein, from Mouse, contains 214 amino acids, is membrane-bound, locates in Cell membrane.

Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery (PubMed:22940130, PubMed:22275436, PubMed:30174147), Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes (PubMed:15550542, PubMed:3410303, PubMed:22753477), Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center (PubMed:22940130, PubMed:22275436), Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell (PubMed:19240024, PubMed:30174147), Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport (PubMed:30174147), Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (PubMed:19240024), Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024), Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye (PubMed:19240024), May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (Probable)


This is Pre-mRNA-processing factor 40 homolog B protein, from Human, contains 871 amino acids, locates in Nucleus.


This is F-box and leucine-rich protein 22 protein, from Human, contains 247 amino acids, is soluble, locates in Cytoplasm.

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC)


This is U3 small nucleolar RNA-associated protein 25 homolog protein, from Zebrafish, contains 753 amino acids, locates in Nucleus.

Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (PubMed:28263972), Essential for embryonic development in part through the regulation of p53 pathway, Required for the expansion growth of intestine, liver and exocrine pancreas, but not endocrine pancreas, May not play a major role during the early stage of endodermal organogenesis, Also involved in the sympathetic neuronal development (PubMed:28263972), Triggers the degradation of p53/TP53 and Delta113p53 isoform in a ubiquitination pathway independent way (PubMed:23357851), Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329)


This is Guanine nucleotide-binding protein-like 3-like protein protein, from Mouse, contains 577 amino acids, locates in Nucleus.

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML, Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation, Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase, Required for cell proliferation, By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition, Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation, By acting on MDM2, may affect TP53 activity, Required for normal processing of ribosomal pre-rRNA, Binds GTP (By similarity)

Belongs to the TRAFAC class YlqF/YawG GTPase family


This is Serine/threonine-protein kinase ULK3 protein, from Human, contains 472 amino acids, is soluble, locates in Cytoplasm.

Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy, Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3), Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation, Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently, Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily


This is Fidgetin-like protein 1 protein, from Human, contains 674 amino acids, locates in Nucleus.

Involved in DNA double-strand break (DBS) repair via homologous recombination (HR), Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner, May regulate osteoblast proliferation and differentiation (PubMed:23754376), May play a role in the control of male meiosis dynamic (By similarity)


This is T-cell receptor-associated transmembrane adapter 1 protein, from Human, contains 186 amino acids, is membrane-bound, locates in Cell membrane.

Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells


This is Nitrophorin-7 protein, from Triatomid bug, contains 205 amino acids, is soluble, locates in Extracellular.

Converts nitrite as the sole substrate to form nitric oxide gas (NO), NO(2-) serves both as an electron donor and as an electron acceptor, Binds to negatively charged cell surfaces of activated platelets; binds to L-a-phosphatidyl-L-serine (PS)-bearing phospholipid membranes, Once bound on an activated platelet, NP7 releases its stored nitric oxide gas (NO) into the victim's tissues while feeding, resulting in vasodilation and inhibition of platelet aggregation, Also acts as an anticoagulant by blocking coagulation-factor binding sites, Has antihistamine activity; binds histamine with high affinity

Belongs to the calycin superfamily, Nitrophorin family


This is E3 ubiquitin-protein ligase RMA1H1 protein, from Capsicum pepper, contains 252 amino acids, has 1 RING-type Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type

E3 ubiquitin-protein ligase required for aquaporin levels regulation


This is CMRF35-like molecule 8 protein, from Mouse, contains 318 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:12874256, PubMed:12893283, PubMed:16339535), Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity)


This is SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 protein, from Human, contains 483 amino acids, locates in Nucleus.

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology), Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner, Stimulates nuclear receptor mediated transcription, Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex), During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state, The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes, As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF), The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells, The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)


This is Endoplasmic reticulum metallopeptidase 1 protein, from Rat, contains 898 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures


This is Ubiquinol-cytochrome-c reductase complex assembly factor 3 protein, from Human, contains 93 amino acids, is membrane-bound, locates in Mitochondrion.

Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex, Thereby, plays an important role in ATP production by mitochondria, Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology


This is Netrin receptor UNC5D protein, from Human, contains 953 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Ig-like C2-type

Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity), Plays a role in cell-cell adhesion and cell guidance, Receptor for netrin involved in cell migration, Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity), May play a role in apoptosis in response to DNA damage (PubMed:24691657), It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068), Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity)


This is Sclerostin domain-containing protein 1 protein, from Human, contains 206 amino acids, is soluble, locates in Extracellular.

May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity), Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner


This is RNA-binding motif, single-stranded-interacting protein 3 protein, from Human, contains 437 amino acids, is soluble, locates in Cytoplasm.

Binds poly(A) and poly(U) oligoribonucleotides


This is Lysosomal amino acid transporter 1 homolog protein, from Human, contains 291 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes


This is Speckle-type POZ protein protein, from Mouse, contains 374 amino acids, locates in Nucleus.

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation, The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL (By similarity), In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3, In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation, Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation, Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (By similarity)


This is Thioredoxin domain-containing protein 3 protein, from Rat, contains 587 amino acids, is soluble, locates in Cytoplasm.

Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs, May be involved in the reduction of disulfide bonds within the sperm FS components, In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds (By similarity)

In the C-terminal section; belongs to the NDK family


This is Thioredoxin domain-containing protein 3 protein, from Mouse, contains 586 amino acids, is soluble, locates in Cytoplasm.


This is UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter protein, from Human, contains 337 amino acids, is membrane-bound, locates in Golgi apparatus.

Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars), May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling

Belongs to the TPT transporter family, SLC35D subfamily


This is Transcription factor MafG protein, from Rat, contains 189 amino acids, locates in Nucleus.

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (By similarity), However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (By similarity), Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (By similarity), Transcription factor, component of erythroid-specific transcription factor NFE2L2 (By similarity), Activates globin gene expression when associated with NFE2L2 (By similarity), May be involved in signal transduction of extracellular H(+) (PubMed:11583919)

Belongs to the bZIP family, Maf subfamily


This is Protein jagunal protein, from Fruit fly, contains 197 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for endoplasmic reticulum organization and proper vesicular traffic during vitellogenesis, Required for oocyte and bristle growth


This is Longitudinals lacking protein-like protein, from Fruit fly, contains 127 amino acids, locates in Nucleus.

Required, together with Trl, for maintaining the repressed state of target genes including homeotic genes Scr and Ubx, May also be involved in the activation of homeotic genes, Binds to a DNA Polycomb response element (PRE) at the bithorax complex, Also binds to polytene chromosomes at several hundred sites, many of which are shared with Trl and ph-p, Required during embryonic development


This is Protein TRC8 homolog protein, from Fruit fly, contains 809 amino acids, has 1 RING-type; atypical Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type; atypical

Plays a role in growth inhibition that is dependent upon COP9 signalosome subunits CSN5 and CSN6, May modulate signalosome levels or compartmentalization, Probably functions in the same or a related pathway to VHL during early midline development


This is tRNA methyltransferase 10 homolog C protein, from Human, contains 403 amino acids, is soluble, locates in Mitochondrion.

Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592), Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158), Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705), The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678), The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705), In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297), Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly

Belongs to the class IV-like SAM-binding methyltransferase superfamily, TRM10 family


This is Isoaspartyl peptidase/L-asparaginase protein, from Human, contains 308 amino acids, is soluble, locates in Cytoplasm.

Has both L-asparaginase and beta-aspartyl peptidase activity, May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions, Is highly active with L-Asp beta-methyl ester, Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys, Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn, Likewise, has no activity toward glutamine


This is Fc receptor-like A protein, from Human, contains 359 amino acids, has 2 Ig-like C2-type Immunoglobulin domain, is soluble, locates in Cytoplasm.

Ig-like C2-type

Ig-like C2-type

May be implicated in B-cell differentiation and lymphomagenesis


This is Fatty acid 2-hydroxylase protein, from Human, contains 372 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15337768, PubMed:15863841, PubMed:17355976, PubMed:22517924), FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (PubMed:22517924), Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity), Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (PubMed:17355976), Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (By similarity), Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity)

Belongs to the sterol desaturase family, SCS7 subfamily


This is Deuterosome assembly protein 1 protein, from Mouse, contains 601 amino acids, is soluble, locates in Cytoplasm.

Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells, Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles, Probably sufficient for the specification and formation of the deuterosome inner core, Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis


This is Kininogen-1a protein, from Giant fire-bellied toad, contains 294 amino acids, is soluble, locates in Extracellular.

Plays a role in the control of feeding by the brain; intracerebroventricular administration of the peptide induced significant decrease in food intake in rats, Inhibits the bradykinin-induced in vitro relaxation of rat arterial smooth muscle, May target bradykinin receptors (BDKRB)

Belongs to the bradykinin-related peptide family


This is Free fatty acid receptor 4 protein, from Mouse, contains 361 amino acids, is membrane-bound, locates in Cell membrane.

G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation, Signals via G-protein and beta-arrestin pathways (PubMed:27852822, PubMed:26873857), LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs) (PubMed:27852822, PubMed:26873857), After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed:27852822, PubMed:26873857), In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation (PubMed:17250804, PubMed:22343897, PubMed:27853148, PubMed:29343498, PubMed:31761534), Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry (PubMed:31761534), Induces differentiation of brown and beige adipocytes probably via autocrine and endocrine functions of FGF21 hormone (PubMed:27853148, PubMed:29343498), Contributes to the thermogenic activation of brown adipose tissue and the browning of white adipose tissue (PubMed:27853148, PubMed:29343498), Activates brown adipocytes by initiating intracellular calcium signaling leading to mitochondrial depolarization and fission, and overall increased mitochondrial respiration (PubMed:29343498), Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass (PubMed:29343498), Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins (PubMed:26365922), In response to dietary fats regulates hormone secretion and appetite (PubMed:15619630, PubMed:25535828, PubMed:24742677, PubMed:24663807, PubMed:24222669), Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels (PubMed:15619630, PubMed:25535828, PubMed:24742677), Negatively regulates glucose-induced SST secretion in pancreatic delta cells (PubMed:24663807), Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone (PubMed:24222669), In taste buds, contributes to sensing of dietary fatty acids by the gustatory system (PubMed:20573884), During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue (PubMed:20813258), Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation (By similarity), In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1 (PubMed:20813258), Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of pro-inflammatory cytokine release (By similarity), Mediates LCFAs anti-apoptotic effects (PubMed:15774482)

Belongs to the G-protein coupled receptor 1 family


This is Acyl-coenzyme A synthetase ACSM4, mitochondrial protein, from Rat, contains 580 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:12709059), Capable of activating medium-chain fatty acids with a preference for C6-12 fatty acids (PubMed:12709059)

Belongs to the ATP-dependent AMP-binding enzyme family


This is Transcription factor EAT1 protein, from Rice, contains 464 amino acids, locates in Nucleus.

Transcription factor involved in the regulation of tapetum programmed cell death (PCD) and degradation during male reproductive development (PubMed:23519457, PubMed:23385589), Interacts with TDR and promote tapetal PCD by regulating the expression of RTS, and the two lipid-transfer proteins C4 and C6, which function in microspore development (PubMed:23519457), Acts downstream from and interacts with TDR in the regulation of tapetal PCD, Regulates directly the aspartic protease AP25 and AP37 during tapetal PCD (PubMed:23385589), May not target the cysteine protease CP1 (PubMed:23519457, PubMed:23385589)


This is Protein TIC 56, chloroplastic protein, from Mouse-ear cress, contains 527 amino acids, is membrane-bound, locates in Plastid.

Involved in protein precursor import into chloroplasts, May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope


This is Schlafen family member 11 protein, from Human, contains 901 amino acids, locates in Nucleus.

Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061), Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061), Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061), Acts independently of ATR (PubMed:29395061), Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900), Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900), Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900), The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900), Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900)

Belongs to the Schlafen family, Subgroup III subfamily


This is Spindle assembly abnormal protein 6 homolog protein, from Zebrafish, contains 627 amino acids, is soluble, locates in Cytoplasm.

Central scaffolding component of the centrioles ensuring their 9-fold symmetry (PubMed:21273447), Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity)


This is Fez family zinc finger protein 2 protein, from Zebrafish, contains 430 amino acids, has 6 C2H2-type Zinc finger, locates in Nucleus.

Transcription repressor, Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Max dimerization protein 3 protein, from Mouse, contains 206 amino acids, locates in Nucleus.

Transcriptional repressor, Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3', Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation