This is Dicarboxylate carrier SLC25A8 protein, from Mouse, contains 309 amino acids, is membrane-bound, locates in Mitochondrion.

Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance, Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle lowering the ATP/ADP ratio and reactive oxygen species (ROS) production (By similarity), Proton transporter activity is debated, but if it occurs it may mediate inducible proton re-entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress, Proton re-entry may be coupled to metabolite transport to allow for proton flux switching and optimal ATP turnover (PubMed:12011051, PubMed:11756659) (By similarity), Regulates the use of glucose as a source of energy, Required for glucose-induced DRP1-dependent mitochondrial fission and neuron activation in the ventromedial nucleus of the hypothalamus (VMH), This mitochondrial adaptation mechanism modulates the VMH pool of glucose-excited neurons with an impact on systemic glucose homeostasis (PubMed:26919426), Regulates ROS levels and metabolic reprogramming of macrophages during the resolution phase of inflammation, Attenuates ROS production in response to IL33 to preserve the integrity of the Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (PubMed:34644537), Can unidirectionally transport anions including L-malate, L-aspartate and phosphate (By similarity), Does not mediate adaptive thermogenesis (PubMed:11101840)

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Sodium/calcium exchanger 1 protein, from Mouse, contains 970 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8659820), Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:8659820), In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum (PubMed:8659820), SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:10967099), Required for normal embryonic heart development and the onset of heart contractions (PubMed:10967099)

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2,A,19) family, SLC8 subfamily


This is ATP-sensitive inward rectifier potassium channel 10 protein, from Human, contains 379 amino acids, is membrane-bound, locates in Cell membrane.

May be responsible for potassium buffering action of glial cells in the brain, Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it, Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages, The inward rectification is mainly due to the blockage of outward current by internal magnesium, Can be blocked by extracellular barium and cesium (By similarity), In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules

Belongs to the inward rectifier-type potassium channel (TC 1,A,2,1) family, KCNJ10 subfamily


This is Neutrophil gelatinase-associated lipocalin protein, from Human, contains 198 amino acids, is soluble, locates in Extracellular.

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821), Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context, Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration, In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration, Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity), Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864), Can also bind siderophores from M,tuberculosis (PubMed:15642259, PubMed:21978368)

Belongs to the calycin superfamily, Lipocalin family


This is NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial protein, from Potato, contains 229 amino acids, is membrane-bound, locates in Mitochondrion.

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis, Complex I functions in the transfer of electrons from NADH to the respiratory chain, The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity), May donate electrons to ubiquinone

Belongs to the complex I 23 kDa subunit family


This is Phosphoglycerate mutase protein, from Yeast, contains 248 amino acids, is soluble, locates in Cytoplasm.

Belongs to the phosphoglycerate mutase family, BPG-dependent PGAM subfamily


This is Lysozyme 1 protein, from Eastern oyster, contains 184 amino acids, is soluble, locates in Extracellular.

Has antibacterial activity against the Gram-positive bacteria L,garvieae, M,luteus and Enterococcus sp,, and the Gram-negative bacteria E,coli and V,vulnificus, Weak antibacterial activity against the Gram-negative bacterium A,hydrophila, No antibacterial activity detected against the Gram-positive bacterium S,iniae or against the Gram-negative bacterium E,ictaluri, Shows some chitinase activity but no isopeptidase activity

Belongs to the glycosyl hydrolase 22 family, Type-I lysozyme subfamily


This is Small ribosomal subunit protein RACK1 protein, from Yeast, contains 317 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable), Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, it serves as a scaffold protein that can recruit other proteins to the ribosome (By similarity), Involved in the negative regulation of translation of a specific subset of proteins (By similarity), Plays a role in morphogenesis and pathogenesis (PubMed:20929924)

Belongs to the WD repeat G protein beta family, Ribosomal protein RACK1 subfamily


This is Thrombin-like enzyme elegaxobin-2 protein, from Elegant pitviper, contains 233 amino acids, is soluble, locates in Extracellular.

Thrombin-like snake venom serine protease that clots rabbit fibrinogen, Only the beta chain of fibrinogen (FGB) is cleaved, releasing fibrinopeptide B, Human and bovine fibrinogen are unaffected, Also cleaves Met-Lys and Arg-Ser bonds in heat-denatured bovine plasma kininogen to release Lys-bradykinin

Belongs to the peptidase S1 family, Snake venom subfamily


This is Lipolysis-activating peptide 1-beta chain protein, from Common European scorpion, contains 95 amino acids, is soluble, locates in Extracellular.

The monomer edited version, similar to alpha-toxins, may modulate voltage-gated sodium channels (Nav) and may block voltage-gated potassium channels (Kv)

Belongs to the long (3 C-C) scorpion toxin superfamily


This is Thrombin-like enzyme kangshuanmei protein, from Korean slamosa snake, contains 236 amino acids, is soluble, locates in Extracellular.

Thrombin-like snake venom serine protease, Cleaves bonds after Arg and Lys, converts fibrinogen (FGA and FGB) to fibrin and releases both fibrinopeptides A and B, and fibrinogen peptide Bbeta1-42, Has a blood clotting activity


This is Alpha-conotoxin SrIA/SrIB protein, from Alphabet cone, contains 69 amino acids, is soluble, locates in Extracellular.

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them, Has weak blocking effects on muscle nAChR composed of alpha-1/beta-1/gamma/delta subunits and the central nervous system nAChR composed of alpha-4/beta-2 subunits, Does not detectably affect the peripheral nervous system nAChR composed of alpha-3/beta-4 subunits, Low toxin concentrations potentiate currents in muscle nAChR composed of alpha-1/beta-1/gamma/delta subunits and central nervous system nAChR composed of alpha-4/beta-2 subunits, but not the peripheral nervous system nAChR composed of alpha-3/beta-4 subunits


This is Spiderine-1a protein, from Lynx spider, contains 166 amino acids, is soluble, locates in Extracellular.

Has antimicrobial, insecticidal, cytolytic and cytotoxic activity, Active against E,coli DH5alpha, E,faecalis VKM B 871, B,subtilis VKM B 501, A,globiformis VKM Ac 1112, P,aeruginosa PAO1 and S,aureus 209P in submicromolar or low micromolar ranges, Lyses human erythrocytes, Kills HeLA and A549 cells

Belongs to the spiderine family, Cationic/spiderine subfamily


This is Cyclotide cter-M protein, from Butterfly pea, contains 127 amino acids, is soluble, locates in Extracellular.

Probably participates in a plant defense mechanism, Displays insecticidal activity against H,armigera, Has weak hemolytic activity, Binds to phospholipid membranes

Belongs to the cyclotide family, Moebius subfamily


This is Thymine dioxygenase JBP1 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 839 amino acids, locates in Nucleus.

Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU), DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation, Also specifically binds to base J-containing DNA (J-DNA), Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis, Thymine dioxygenase activity and J-DNA-binding are independent functions

Belongs to the TET family, JBP1 subfamily


This is DNA repair protein crb2 protein, from Fission yeast, contains 778 amino acids, locates in Nucleus.

Essential for cell cycle arrest at the G1 and G2 stages following DNA damage by X-, and UV-irradiation, or inactivation of DNA ligase, Plays a role in the response to DNA damage (PubMed:9153313, PubMed:9407031), Interaction with rad4 via its phosphorylation sites in the N-terminus couples the DNA checkpoint apparatus to chromatin via interaction of its C-terminal BRCT domains with epigenetic modifications on histones H4 and H2A, respectively, in the G1/S phase of the cell cycle, and facilitates recruitment of the checkpoint kinase chk1 (PubMed:15550243, PubMed:16778077, PubMed:18826944, PubMed:20679485, PubMed:22792081)


This is Metabotropic glutamate receptor protein, from Fruit fly, contains 976 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for glutamate, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors

Belongs to the G-protein coupled receptor 3 family


This is Spindle-defective protein 2 protein, from Caenorhabditis elegans, contains 824 amino acids, is soluble, locates in Cytoplasm.

Required both for centrosome duplication and maturation (PubMed:15068791, PubMed:15186742, PubMed:19081077), Required for pericentriolar material (PCM) recruitment (PubMed:15068791, PubMed:15186742)


This is FMRFamide-related neuropeptides protein, from Common cuttlefish, contains 331 amino acids, is soluble, locates in Extracellular.

Excitatory neurotransmitters that directly modulate chromatophore function by activating chromatophore expansion at the chromatophore neuromuscular junction

Belongs to the FARP (FMRFamide related peptide) family


This is AP-2 complex subunit alpha protein, from Fruit fly, contains 940 amino acids, is membrane-bound, locates in Cell membrane.

Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles, Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration, AP-2alpha is a subunit of the plasma membrane adapter

Belongs to the adaptor complexes large subunit family


This is Protein pangolin, isoforms A/H/I/S protein, from Fruit fly, contains 751 amino acids, locates in Nucleus.

Segment polarity protein, Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues, Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes


This is Polygalacturonase 1 beta-like protein 3 protein, from Mouse-ear cress, contains 626 amino acids, is soluble, locates in Extracellular.

Involved in cell size determination, May serve as a chaperone for expansins through the secretory pathway


This is Phototropin-2 protein, from Mouse-ear cress, contains 915 amino acids, is membrane-bound, locates in Cell membrane.

Protein kinase that acts as a blue light photoreceptor in a signal-transduction pathway for photo-induced movements, Phosphorylates BLUS1, a kinase involved in stomatal opening, Mediates calcium spiking of extra- and intracellular origins in response to blue light, Involved in hypocotyl phototropism, Contributes to the chloroplast accumulation in low blue light and mediates their translocation (avoidance response) at high fluence, Regulates stomata opening and photomorphogenesis response of leaf tissue, Not involved in hypocotyl elongation inhibition, anthocyanin accumulation or cotyledon opening

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family


This is E3 ubiquitin-protein ligase RMA2 protein, from Mouse-ear cress, contains 193 amino acids, has 1 RING-type Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of the auxin-binding protein ERABP1


This is BPI fold-containing family A member 1 protein, from Mouse, contains 278 amino acids, is soluble, locates in Extracellular.

Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (By similarity), Plays a role in the innate immune responses of the upper airways (PubMed:23499554), Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P,aeruginosa and K,pneumoniae (PubMed:23499554), Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (By similarity), Plays a role in the airway inflammatory response after exposure to irritants (By similarity), May attract macrophages and neutrophils (By similarity)

Belongs to the BPI/LBP/Plunc superfamily, Plunc family


This is Serine palmitoyltransferase 2 protein, from Mouse, contains 560 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Serine palmitoyltransferase (SPT), The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core, The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (By similarity), Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (PubMed:28698261)

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family


This is Homeobox protein Meis3 protein, from Mouse, contains 378 amino acids, locates in Nucleus.

Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells, Also regulates expression of NDFIP1, BNIP3, and CCNG1

Belongs to the TALE/MEIS homeobox family


This is Antileukoproteinase protein, from Mouse, contains 131 amino acids, is soluble, locates in Extracellular.

Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:9126337), Modulates the innate immune response after bacterial infection (PubMed:12615907), Contributes to regulate the inflammatory and immune responses to the intracellular parasite L,major (PubMed:25030421), Down-regulates responses to bacterial lipopolysaccharide (LPS) (PubMed:9039268, PubMed:12615907, PubMed:25030421), Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:11017147, PubMed:12615907), Has antimicrobial activity against mycobacteria, but not against salmonella (PubMed:18322212), Contributes to normal resistance against infection by M,tuberculosis (PubMed:18322212), Required for normal resistance to L,major (PubMed:25030421), Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (PubMed:11017147, PubMed:25030421), Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (By similarity)


This is Chemerin-like receptor 1 protein, from Mouse, contains 371 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1, Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis, Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity), Positively regulates adipogenesis and adipocyte metabolism

Belongs to the chemokine-like receptor (CMKLR) family


This is Leukocyte immunoglobulin-like receptor subfamily B member 3 protein, from Mouse, contains 841 amino acids, has 6 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May act as receptor for class I MHC antigens, Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor, Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM)


This is Peroxisomal multifunctional enzyme type 2 protein, from Rat, contains 735 amino acids, locates in Peroxisome.

Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway, Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx, Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Protein giant-lens protein, from Fruit fly, contains 444 amino acids, is soluble, locates in Extracellular.

Regulates cell determination; development of ommatidia and optic lobe, Is a signaling molecule involved in the process of axon pathfinding in the eye, Part of the Ras pathway regulating programmed cell death in pupal eyes; activated by lozenge (lz), Antagonist for the Egfr receptor (gurken), Inhibits Egfr signaling without interacting directly with the receptor, but instead by sequestering the Egfr-activating ligand spitz (spi)


This is Splicing factor U2AF 35 kDa subunit protein, from Human, contains 240 amino acids, has 2 C3H1-type Zinc finger, locates in Nucleus.

Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection, Recruits U2 snRNP to the branch point, Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron

Belongs to the splicing factor SR family


This is Pre-tRNA-processing protein PTA1 protein, from Baker's yeast, contains 785 amino acids, locates in Nucleus.

Essential in pre-tRNA processing, Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB, Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation


This is A-kinase anchor protein 17A protein, from Human, contains 695 amino acids, locates in Nucleus.

Splice factor regulating alternative splice site selection for certain mRNA precursors, Mediates regulation of pre-mRNA splicing in a PKA-dependent manner


This is Dihydroorotate dehydrogenase (quinone), mitochondrial protein, from Human, contains 395 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor, Required for UMP biosynthesis via de novo pathway

Belongs to the dihydroorotate dehydrogenase family, Type 2 subfamily


This is Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 protein, from Rat, contains 882 amino acids, is membrane-bound, locates in Golgi apparatus.

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:1379236, PubMed:3422231, PubMed:8483907, PubMed:9890952), Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:1379236, PubMed:3422231), Plays a role in determining the extent and pattern of sulfation of heparan sulfate, Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (By similarity), Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)

Belongs to the sulfotransferase 1 family, NDST subfamily


This is Protein TBF1 protein, from Baker's yeast, contains 562 amino acids, locates in Nucleus.

Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length, Involved in the regulation of gene expression, 52 binding sites have been identified, distributed over 15 chromosomes, A member of the general regulatory factors (GRFs) which act as genome partitioners, Acts as a chromatin insulator which are known as STARs (Subtelomeric anti-silencing region), STARs prevent negative or positive transcription influence by extending across chromatin to a promoter


This is Pre-mRNA-splicing factor SLU7 protein, from Baker's yeast, contains 382 amino acids, has 1 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type

Essential protein involved in the second catalytic step of pre-mRNA splicing, Involved in the selection of 3'-type splice sites; this selection could be done via a 3'-splice site-binding factor, PRP16


This is Heat shock factor protein protein, from Fission yeast, contains 609 amino acids, locates in Nucleus.

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription, Also required for growth at normal temperatures


This is Cell wall mannoprotein PIR1 protein, from Baker's yeast, contains 341 amino acids, is soluble, locates in Extracellular.

Component of the outer cell wall layer, Required for stability of the cell wall and for optimal growth, Required for resistance against several antifungal and cell wall-perturbing agents and for tolerance to heat shock


This is Cell wall mannoprotein PIR3 protein, from Baker's yeast, contains 325 amino acids, is soluble, locates in Extracellular.

Component of the outer cell wall layer, Required for stability of the cell wall and for optimal growth, Required for resistance against several antifungal and cell wall-perturbing agents


This is DNA replication complex GINS protein SLD5 protein, from Baker's yeast, contains 294 amino acids, locates in Nucleus.

Required for DNA replication, Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery


This is Parathyroid hormone/parathyroid hormone-related peptide receptor protein, from Human, contains 593 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for parathyroid hormone and for parathyroid hormone-related peptide, The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system

Belongs to the G-protein coupled receptor 2 family


This is Glutamate receptor 1 protein, from Fruit fly, contains 991 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for glutamate, L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system, The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity), Forms ligand-gated ion channels which are activated by kainate

Belongs to the glutamate-gated ion channel (TC 1,A,10,1) family


This is Ceramide very long chain fatty acid hydroxylase SCS7 protein, from Baker's yeast, contains 384 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids (PubMed:9353282, PubMed:9368039, PubMed:26977056, PubMed:9559540, PubMed:16652392, PubMed:19074599), Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2 (PubMed:9368039, PubMed:26977056)

Belongs to the sterol desaturase family, SCS7 subfamily


This is tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82 protein, from Baker's yeast, contains 444 amino acids, locates in Nucleus.

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay, In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit


This is Transcriptional activator/repressor GIS1 protein, from Baker's yeast, contains 894 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, locates in Nucleus.

C2H2-type 2; atypical

Transcription factor involved in the regulation of gene expression upon nutrient starvation, Recognizes and binds to the post-diauxic-shift element 5'-T[AT]AGGGAT-3' in the promoter region, Can act as a transcriptional activator (e,g, of stress genes like SSA3, HSP12 and HSP26) as well as a repressor (e,g, of pyrophosphate phosphatase DPP1), GIS1 also acts as a DNA damage-responsive transcriptional repressor of photolyase PHR1


This is tRNA wybutosine-synthesizing protein 2 protein, from Baker's yeast, contains 462 amino acids, is soluble, locates in Cytoplasm.

S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway, Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA, Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86

Belongs to the class I-like SAM-binding methyltransferase superfamily, TRM5/TYW2 family


This is Glucosidase 2 subunit beta protein, from Baker's yeast, contains 702 amino acids, locates in Endoplasmic reticulum.

Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins, Specifically required for the cleavage of the final glucose


This is Transcription initiation factor TFIID subunit 7 protein, from Baker's yeast, contains 590 amino acids, locates in Nucleus.

Functions as a component of the DNA-binding general transcription factor complex TFIID, Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation, TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription, TAF7 is responsible for the recruitment of BDF1 to TATA element containing promoters


This is Mannan endo-1,6-alpha-mannosidase DFG5 protein, from Baker's yeast, contains 458 amino acids, is membrane-bound, locates in Cell membrane.

Required for normal synthesis of the cell wall

Belongs to the glycosyl hydrolase 76 family


This is Actin-like protein ARP9 protein, from Baker's yeast, contains 467 amino acids, locates in Nucleus.

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, This subunit is involved in transcriptional regulation, Heterodimer of ARP9 and ARP7 functions with HMG box proteins to facilitate proper chromatin architecture, Heterodimer formation is necessary for assembly into RSC complex, Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes, It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors


This is Developmental protein eyes absent protein, from Fruit fly, contains 766 amino acids, locates in Nucleus.

Tyrosine phosphatase thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity (PubMed:14628052, PubMed:14628053), The phosphatase activity was shown in vitro, Appears to function together with So and Dac in eye development (PubMed:9428512, PubMed:9428513), Required for the survival of eye progenitor cells at a critical stage in morphogenesis (PubMed:8431945)

Belongs to the HAD-like hydrolase superfamily, EYA family


This is Protein BUR2 protein, from Baker's yeast, contains 395 amino acids, locates in Nucleus.

Component of the BUR kinase complex involved in transcription regulation, This complex phosphorylates 'Ser-120' of the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B, the localization of the PAF1 complex to the chromatin, and the silencing of telomeric-associated genes, Also required for histone H3 'Lys-4' trimethylation, May phosphorylate the 'Ser-5' of the RBP1 carboxy-terminal domain (CTD) repeats, Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase, Also required for vegetative growth itself, The kinase activity of the complex requires the presence of BUR2, Overexpression of BUR2 interferes with mitotic chromosome segregation


This is Endoribonuclease YSH1 protein, from Baker's yeast, contains 779 amino acids, locates in Nucleus.

Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB, Has endonuclease activity

Belongs to the metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, CPSF2/YSH1 subfamily


This is Vacuolar protein sorting-associated protein 74 protein, from Baker's yeast, contains 345 amino acids, is membrane-bound, locates in Golgi apparatus.

Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi, Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus, May also bind to the coatomer to regulate Golgi membrane trafficking, May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion, Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains, Involved in vacuolar protein sorting


This is Chromatin structure-remodeling complex subunit RSC2 protein, from Baker's yeast, contains 889 amino acids, locates in Nucleus.

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, This subunit is involved in meiotic sporulation through regulating IME2 expression, and is also essential for 2-micron plasmid maintenance and for normal REP1 protein localization


This is Palmitoyltransferase ERF2 protein, from Baker's yeast, contains 359 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

The ERF2-SHR5 complex is a palmitoyltransferase specific for Ras proteins, Palmitoylates RAS2, which is required for its proper plasma membrane localization

Belongs to the DHHC palmitoyltransferase family, ERF2/ZDHHC9 subfamily


This is U3 small nucleolar RNA-associated protein 4 protein, from Baker's yeast, contains 776 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA, Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs)


This is Osmolarity two-component system protein SSK1 protein, from Baker's yeast, contains 712 amino acids, is soluble, locates in Cytoplasm.

Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to changes in the osmolarity of the extracellular environment, Under normal osmotic conditions, maintained in a phosphorylated and inactive state by the phosphorelay intermediate protein YPD1, Under conditions of high osmolarity, the histidine kinase SLN1 is no longer active and the unphosphorylated form of SSK1 interacts with and activates SSK2 and SSK22, two MAPKKKs that further stimulate the PBS2-HOG1 MAPKK-MAPK cascade, Unphosphorylated SSK1 is subsequently degraded by the UBC7-dependent ubiquitin-proteasome system to down-regulate the HOG1 pathway after completion of the osmotic adaptation


This is Protein LUC7 protein, from Baker's yeast, contains 261 amino acids, locates in Nucleus.

Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA, Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway


This is Polynucleotide 5'-hydroxyl-kinase GRC3 protein, from Baker's yeast, contains 632 amino acids, locates in Nucleus.

Polynucleotide 5'-kinase involved in rRNA processing, Required for the efficient termination by RNA polymerase I and the processing of the IST2 pre-rRNA internal transcribed spacer localized between the 5,8S and 25S rRNAs, May act by maintaining the phosphorylated status of the downstream RNT1 cleavage product, which in turn allows the torpedo activity of RAT1 to efficiently terminate Pol I transcription, In vitro, displays polynucleotide kinase activity on both single- and double-stranded RNA and on single-stranded DNA alone, but not double-stranded DNA alone

Belongs to the Clp1 family, NOL9/GRC3 subfamily


This is Non-structural maintenance of chromosomes element 1 protein, from Baker's yeast, contains 336 amino acids, has 1 RING-type; atypical Zinc finger, locates in Nucleus.

RING-type; atypical

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage, Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks


This is Mitochondrial distribution and morphology protein 38 protein, from Baker's yeast, contains 573 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation (PubMed:11907266, PubMed:15138253), With MBA1, plays a role in ribosomal translation and protein insertion into the inner membrane (PubMed:20427570)


This is Succinate dehydrogenase assembly factor 2, mitochondrial protein, from Baker's yeast, contains 162 amino acids, is soluble, locates in Mitochondrion.

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol, Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDH1 of the SDH catalytic dimer, It is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDH1 in a conformation that is susceptible to autocatalytic FAD attachment (PubMed:19628817), Does not bind FAD or FADH(2) in vitro (PubMed:23062074), Involved in sporulation (PubMed:12432101), Required for the full activation of the early meiotic inducer IME1 (PubMed:12586695)


This is Ribosome biogenesis protein BRX1 protein, from Baker's yeast, contains 291 amino acids, locates in Nucleus.

Required for biogenesis of the 60S ribosomal subunit


This is Mediator of RNA polymerase II transcription subunit 7 protein, from Baker's yeast, contains 222 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II, The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins

Belongs to the Mediator complex subunit 7 family


This is Cell growth-regulating nucleolar protein protein, from Mouse, contains 388 amino acids, has 2 C2HC LYAR-type Zinc finger, locates in Nucleus.

C2HC LYAR-type

C2HC LYAR-type

Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity), Also acts at the level of transcription regulation, Along with PRMT5, binds embryonic globin promoter (By similarity), Represses the expression of embryonic globin Hbb-y gene (PubMed:25092918), In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41 (By similarity), Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity), Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity), In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (By similarity), Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (PubMed:25735755), Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (PubMed:19489080)


This is Ubiquitin-binding protein CUE5 protein, from Baker's yeast, contains 411 amino acids, is soluble, locates in Cytoplasm.

Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 adapter and thus mediating autophagic clearance of ubiquitin conjugates under starvation conditions, The CUE5-dependent selective autophagy pathway plays an important role in clearance of cytotoxic protein aggregates, Not required for cytoplasmic to vacuole pathway (cvt), mitophagy, pexophagy, or ribophagy


This is Protein YNG1 protein, from Baker's yeast, contains 219 amino acids, has 1 PHD-type; degenerate Zinc finger, locates in Nucleus.

PHD-type; degenerate

Histone-binding component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3, Recruitment of NuA3 to nucleosomes requires methylated histone H3, In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation, YNG1 is required for the HAT activity of NuA3 but not for its integrity, Mediates the interaction of SAS3 with nucleosomes


This is Transcription factor GAGA protein, from Fruit fly, contains 581 amino acids, has 1 C2H2-type; degenerate Zinc finger, locates in Nucleus.

C2H2-type; degenerate

Transcriptional activator that functions by regulating chromatin structure, Overcomes the repressive effects of chromatin by promoting the open chromatin conformation in promoter gene regions, thereby allowing access to other transcription factors, Binds to DNA Polycomb response elements (PREs) at the bithorax complex and to the proximal region of the engrailed promoter, and positively regulates transcription of many genes including homeotic ones, Binds to the DNA sequence (GA)n, with optimal binding to the pentamer 5'-GAGAG-3', Binds DNA as an oligomer, May also act as a transcriptional repressor, maintaining the repressed state of genes including lolal, and down-regulating its own transcription, Required for dosage compensation in males and may be involved in oogenesis, Also has a role in nuclear division


This is Tyrosine-protein kinase ITK/TSK protein, from Human, contains 620 amino acids, has 1 Btk-type Zinc finger, is soluble, locates in Cytoplasm.

Btk-type

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response, Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells, When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK, Phosphorylation leads to ITK autophosphorylation and full activation, Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates, In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty, Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2, Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281), Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity), Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily


This is S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase protein, from Baker's yeast, contains 810 amino acids, locates in Endoplasmic reticulum.

Component of the wybutosine biosynthesis pathway, Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA, Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity)


This is Protein adenylyltransferase SelO, mitochondrial protein, from Baker's yeast, contains 688 amino acids, locates in Mitochondrion.

Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Tyr residues of target mitochondrial proteins (AMPylation) (PubMed:30270044), Involved in redox homeostasis by regulating the cellular response to oxidative stress (PubMed:30270044), Regulates protein S-glutathionylation levels possibly by AMPylation of deglutathionylation enzymes such as glutaredoxins (PubMed:30270044)


This is Dibasic-processing endoprotease protein, from Fission yeast, contains 709 amino acids, is membrane-bound, locates in Golgi apparatus.

Membrane-bound, subtilisin-like serine protease that processes the P-factor precursor and other precursor proteins, Essential for cell viability, Cleaves substrate on the C-terminal side of dibasic residues

Belongs to the peptidase S8 family, Furin subfamily


This is Pre-mRNA-splicing factor dre4 protein, from Fission yeast, contains 411 amino acids, locates in Nucleus.

Component of the spliceosome involved in mRNA processing


This is SMN complex subunit smn1 protein, from Fission yeast, contains 152 amino acids, locates in Nucleus.

The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:20400941, PubMed:33754639, PubMed:10749974), Most spliceosomal snRNPs contain a common set of Sm proteins smb1, smd1, smd2, smd3, sme1, smf1 and smg1 that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity), In the cytosol, the Sm proteins smd1, smd2, sme1, smf1 and smg1 (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone saf5 that controls the assembly of the core snRNP (By similarity), To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from saf5 forming an intermediate (By similarity), Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of smd3 and smb1 to complete assembly of the core snRNP (By similarity), Within the SMN complex, smn1 acts as a structural backbone and together with yip11/gem2 it gathers the Sm complex subunits (PubMed:33754639)


This is Protein stn1 protein, from Fission yeast, contains 325 amino acids, locates in Nucleus.


This is E3 ubiquitin-protein ligase NEURL1B protein, from Mouse, contains 546 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands


This is Receptor for retinol uptake STRA6 protein, from Bovine, contains 668 amino acids, is membrane-bound, locates in Cell membrane.

Functions as retinol transporter, Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:17255476, PubMed:18419130), Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A, Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin, Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid, STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency, Does not transport retinoic acid (By similarity)


This is Leiomodin-3 protein, from Human, contains 560 amino acids, is soluble, locates in Cytoplasm.

Essential for the organization of sarcomeric actin thin filaments in skeletal muscle (PubMed:25250574), Increases the rate of actin polymerization (PubMed:25250574)


This is Cyclin-dependent kinase inhibitor 6 protein, from Mouse-ear cress, contains 196 amino acids, is soluble, locates in Nucleus.

Binds and inhibits CYCD2-1/CDKA-1 complex kinase activity, Regulates cell division which is crucial for plant growth, development and morphogenesis, May inhibit CDK kinases specifically involved in the G1/S phase transition

Belongs to the CDI family, ICK/KRP subfamily


This is Molybdate transporter 2 protein, from Mouse-ear cress, contains 464 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Molybdate transporter required for vacuolar molybdate export during senescence

Belongs to the SLC26A/SulP transporter (TC 2,A,53) family


This is AUGMIN subunit 3 protein, from Mouse-ear cress, contains 617 amino acids, is soluble, locates in Cytoplasm.

Involved in microtubules reorganization during spindle and phragmoplast development, Required for gamma-tubulin localization during mitosis


This is Probable serine/threonine-protein kinase PBL7 protein, from Mouse-ear cress, contains 378 amino acids, is membrane-bound, locates in Cell membrane.

Serine/threonine-protein kinase involved in the positive regulation of brassinosteroid (BR) signaling and plant growth, Phosphorylates both BSU1 and BSL1 in vitro

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is 2-carboxy-1,4-naphthoquinone phytyltransferase, chloroplastic protein, from Mouse-ear cress, contains 382 amino acids, is membrane-bound, locates in Plastid.

Involved in the synthesis of phylloquinone (vitamin K1), Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4-naphthoquinone

Belongs to the MenA family, Type 2 subfamily


This is Putative E3 ubiquitin-protein ligase RING1b protein, from Mouse-ear cress, contains 460 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

As part of the PRC1-like complex, repress class I KNOX gene expression, PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility


This is Lap-Emerin-Man domain protein 2 protein, from Fission yeast, contains 688 amino acids, is membrane-bound, locates in Nucleus.

Nucleus inner membrane protein involved in meiosis (PubMed:20404563), Plays a role in regulating nuclear envelope (NE) morphology and nuclear integrity, particularly during spindle pole body (SPB) extrusion or insertion through the NE, and perhaps during karyokinesis (PubMed:28242692)


This is Exosome complex exonuclease rrp6 protein, from Fission yeast, contains 777 amino acids, locates in Nucleus.

Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events, In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm, The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes, RRP6 has 3'-5' exonuclease activity which is not modulated upon association with Exo-9 suggesting that the complex inner RNA-binding path is not used to access its active site (By similarity)

Belongs to the exosome component 10/RRP6 family


This is Eukaryotic translation initiation factor 3 subunit B protein, from Fission yeast, contains 725 amino acids, is soluble, locates in Cytoplasm.

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome, The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation


This is Sphingomyelin phosphodiesterase 1 protein, from Caenorhabditis elegans, contains 564 amino acids, is soluble, locates in Extracellular.

Sphingomyelin phosphodiesterase (sphingomyelinase) that converts sphingomyelin to ceramide (N-acyl-sphingoid base) and phosphocholine at acidic pH, Displays its enzymatic activity when secreted, May play distinct roles in signaling

Belongs to the acid sphingomyelinase family


This is Protein BIG GRAIN 1 protein, from Rice, contains 310 amino acids, is membrane-bound, locates in Cell membrane.

Involved in auxin transport, Positive regulator of the auxin signaling pathway involved in gravitropism, plant growth and grain development

Belongs to the BIG GRAIN 1 (BG1) plant protein family


This is Pre-mRNA-splicing factor CWC2 protein, from Baker's yeast, contains 339 amino acids, has 1 C3H1-type Zinc finger, locates in Nucleus.

Involved in the first step of pre-mRNA splicing, Required for cell growth and cell cycle control, Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex, May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA, Associates predominantly with U6 snRNAs in assembled active spliceosomes, Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle, Binds also to U1, U4, U5 and U6 snRNAs and to pre-mRNAs, in vitro, Is not required for the Prp2-mediated remodeling of the activated spliceosome


This is Telomere length regulation protein ELG1 protein, from Baker's yeast, contains 791 amino acids, locates in Nucleus.

Involved in the negative control of telomere length and in telomeric silencing through a replication-mediated pathway, May have a role in Okazaki fragment maturation, Required for S-phase progression, Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair


This is Trimethylguanosine synthase protein, from Baker's yeast, contains 315 amino acids, locates in Nucleus.

Catalyzes the two serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure, The enzyme is specific for guanine, and N7 methylation must precede N2 methylation, Hypermethylates the m3G cap on TLC1 telomerase which affects telomere silencing and telomere length regulation, Required for pre-mRNA splicing, pre-rRNA processing and small ribosomal subunit synthesis, Involved in nucleolar structural organization

Belongs to the methyltransferase superfamily, Trimethylguanosine synthase family


This is Small glutamine-rich tetratricopeptide repeat-containing protein 2 protein, from Baker's yeast, contains 346 amino acids, is soluble, locates in Cytoplasm.

Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2), Regulates Hsp70 ATPase activity (By similarity), Required for recovery from heat shock


This is DNA replication complex GINS protein PSF3 protein, from Baker's yeast, contains 194 amino acids, locates in Nucleus.

Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery


This is Glucan endo-1,3-beta-D-glucosidase 2 protein, from Baker's yeast, contains 779 amino acids, is soluble, locates in Cytoplasm.

Cleaves internal linkages in 1,3-beta-glucan

Belongs to the glycosyl hydrolase 81 family


This is Meiotic recombination protein REC8 protein, from Baker's yeast, contains 680 amino acids, locates in Nucleus.

Replaces the SCC1 mitosis-specific cohesin to ensure sister chromatid cohesion during meiosis (PubMed:10412984, PubMed:10691741, PubMed:11081626, PubMed:11163190, PubMed:12101124, PubMed:12663816, PubMed:12665553, PubMed:12717442, PubMed:15062096, PubMed:15120066, PubMed:15819623, PubMed:16027219, PubMed:9784122), Is cleaved by ESP1 shortly before the first meiotic division, and dissociates from chromatin, allowing sister chromatids to segregate (PubMed:11081626), Is protected from cleavage by SPO13 (PubMed:15620644), Promotes localization of the LINC complex subunit MPS3 on nuclear envelope in mitotic cells (PubMed:30417519)


This is G protein-coupled receptor GPR1 protein, from Baker's yeast, contains 961 amino acids, is membrane-bound, locates in Cell membrane.

Seems to associate with GPA2 and act as G protein-coupled receptor that senses glucose and controls filamentous growth, It acts upstream of adenylate cyclase and is required for glucose activation of cAMP synthesis in concert with a glucose phosphorylation-dependent mechanism

Belongs to the G-protein coupled receptor GPR1/git3 family


This is HAT1-interacting factor 1 protein, from Baker's yeast, contains 385 amino acids, locates in Nucleus.

Histone H3 and H4 specific chaperone component of the nuclear histone acetyltransferase B (HAT-B) complex, Involved in chromatin assembly and telomere silencing


This is Diphthine--ammonia ligase protein, from Baker's yeast, contains 685 amino acids, is soluble, locates in Cytoplasm.

Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP, Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EFT1 or EFT2) to diphthamide

In the N-terminal section; belongs to the Diphthine--ammonia ligase family


This is Peroxisomal membrane protein PMP27 protein, from Baker's yeast, contains 236 amino acids, is membrane-bound, locates in Peroxisome.

Involved in peroxisomal proliferation, Promotes peroxisome division and biogenesis


This is DNA replication complex GINS protein PSF1 protein, from Baker's yeast, contains 208 amino acids, locates in Nucleus.

Required for DNA replication, Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery, Required for the chromatin binding of CDC45


This is Peroxisomal coenzyme A diphosphatase 1, peroxisomal protein, from Baker's yeast, contains 340 amino acids, locates in Peroxisome.

Diphosphatase (pyrophosphatase) with specificity for coenzyme A and CoA derivatives, Catalyzes the hydrolysis of the diphosphate linkage in CoA to give 3',5'-ADP and 4'-phosphopantetheine, Prefers oxidized CoA disulfide (CoASSCoA) over CoA as a substrate, May be required to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids (PubMed:10922370), Can also hydrolyze 8-oxo-dGTP and 2-OH-dATP in vitro; therefore it may function as a sanitizing enzyme for oxidized nucleotides and may contribute to prevention of spontaneous mutagenesis due to the misincorporation of these oxidized nucleotides during DNA synthesis (PubMed:15475388), Shows moderate activity in vitro with several short chain acyl-CoA esters and very low activity on 3'-dephospho-CoA while is not active with (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di- or monophosphates, diadenosine polyphosphates, nucleoside 5'-diphosphosugars, cytidine 5'-diphosphoalcohols, NAD(+), NADH, or FAD (PubMed:10922370)

Belongs to the Nudix hydrolase family, PCD1 subfamily


This is Histone H2A.Z protein, from Baker's yeast, contains 134 amino acids, locates in Nucleus.

Variant histone H2A which can replace H2A in some nucleosomes, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling, This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received (PubMed:11000274, PubMed:11081628, PubMed:11090616, PubMed:11509669, PubMed:12628191, PubMed:14645854, PubMed:14690608, PubMed:15045029, PubMed:16239142, PubMed:16344463, PubMed:16543223), Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins (PubMed:16543222), Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes (PubMed:11509669), Involved in chromosome stability (PubMed:15353583), Required to target MPS3 to the inner membrane of the nuclear envelope (PubMed:21518795)


This is Serine/threonine-protein kinase psk1 protein, from Fission yeast, contains 436 amino acids, is soluble, locates in Cytoplasm.

AGC kinase which plays a role in TOR complex 1 (TORC1) signaling pathway which mediates temporal control of cell growth in response to nutrients, Required for phosphorylation of ribosomal protein S6 (rps601/rps602) at 'Ser-235' and 'Ser-236'

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily


This is Alpha-globin transcription factor CP2 protein, from Human, contains 502 amino acids, locates in Nucleus.

Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters, Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity), Functions as part of the SSP (stage selector protein) complex, Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells, Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter

Belongs to the grh/CP2 family, CP2 subfamily


This is TNF receptor-associated factor 2 protein, from Human, contains 501 amino acids, has 1 RING-type Zinc finger, has 2 TRAF-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

TRAF-type

TRAF-type

Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis (PubMed:22212761), Required for normal antibody isotype switching from IgM to IgG, Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1, Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases, Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain, Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR, In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE

Belongs to the TNF receptor-associated factor family, A subfamily


This is TAR DNA-binding protein 43 protein, from Human, contains 414 amino acids, locates in Nucleus.

RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609), Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995), In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978), Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432), Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513), In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:23398327, PubMed:19765185), Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263), Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980), Negatively regulates the expression of CDK6 (PubMed:19760257), Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563)


This is E3 ubiquitin-protein ligase CBL-B protein, from Human, contains 982 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome, Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways, In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production, Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation, In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy, In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation, Slightly promotes SRC ubiquitination, May be involved in EGFR ubiquitination and internalization, May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3, In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity)


This is Corticotropin-releasing factor receptor 2 protein, from Human, contains 411 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3, Has high affinity for UCN, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase, Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels

Belongs to the G-protein coupled receptor 2 family


This is Mastermind-like domain-containing protein 1 protein, from Human, contains 774 amino acids, locates in Nucleus.

Transactivates the HES3 promoter independently of NOTCH proteins, HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ


This is MORC family CW-type zinc finger protein 3 protein, from Human, contains 939 amino acids, has 1 CW-type Zinc finger, is soluble, locates in Nucleus.

CW-type

(Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233)


This is Large ribosomal subunit protein mL62 protein, from Human, contains 206 amino acids, locates in Mitochondrion.

Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit, Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation, May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes

Belongs to the prokaryotic/mitochondrial release factor family, Mitochondrion-specific ribosomal protein mL62 subfamily


This is E3 ubiquitin/ISG15 ligase TRIM25 protein, from Human, contains 630 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599), Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:30193849, PubMed:33849980, PubMed:29357390, PubMed:31710640), Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712), Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849), Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755), Mediates estrogen action in various target organs (PubMed:22452784), Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784), Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity), Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses, Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28202764, PubMed:28060952), Mediates also the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236)


This is WAP four-disulfide core domain protein 2 protein, from Human, contains 124 amino acids, is soluble, locates in Extracellular.


This is Maternal embryonic leucine zipper kinase protein, from Human, contains 651 amino acids, is membrane-bound, locates in Cell membrane.

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation, Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622, Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1, Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis, Plays a key role in cell proliferation and carcinogenesis, Required for proliferation of embryonic and postnatal multipotent neural progenitors, Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14, Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus, May also play a role in primitive hematopoiesis

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily


This is Metabotropic glutamate receptor 3 protein, from Human, contains 879 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for glutamate, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, Signaling inhibits adenylate cyclase activity

Belongs to the G-protein coupled receptor 3 family


This is Metabotropic glutamate receptor 4 protein, from Human, contains 912 amino acids, is membrane-bound, locates in Cell membrane.


This is N-alpha-acetyltransferase 25, NatB auxiliary subunit protein, from Human, contains 972 amino acids, is soluble, locates in Cytoplasm.

Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln, May play a role in normal cell-cycle progression


This is Rab3 GTPase-activating protein catalytic subunit protein, from Human, contains 981 amino acids, is soluble, locates in Cytoplasm.

Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:9030515, PubMed:10859313, PubMed:24891604), As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (PubMed:10859313), Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (PubMed:15696165), The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604), Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604), Required for normal eye and brain development (PubMed:15696165, PubMed:23420520), May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (PubMed:9030515, PubMed:9852129)

Belongs to the Rab3-GAP catalytic subunit family


This is Mitochondrial inner membrane protein OXA1L protein, from Human, contains 435 amino acids, is membrane-bound, locates in Mitochondrion.

Required for the insertion of integral membrane proteins into the mitochondrial inner membrane, Essential for the activity and assembly of cytochrome oxidase, Required for the correct biogenesis of ATP synthase and complex I in mitochondria


This is Transforming growth factor-beta-induced protein ig-h3 protein, from Human, contains 683 amino acids, is soluble, locates in Extracellular.

Plays a role in cell adhesion (PubMed:8024701), May play a role in cell-collagen interactions (By similarity)


This is Kynureninase protein, from Human, contains 465 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively, Has a preference for the L-3-hydroxy form, Also has cysteine-conjugate-beta-lyase activity


This is ATP-dependent Clp protease proteolytic subunit, mitochondrial protein, from Human, contains 277 amino acids, is soluble, locates in Mitochondrion.

Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process, Has low peptidase activity in the absence of CLPX, The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (PubMed:11923310, PubMed:15522782), Cleaves PINK1 in the mitochondrion (PubMed:22354088)


This is Membrane primary amine oxidase protein, from Human, contains 763 amino acids, is membrane-bound, locates in Cell membrane.

Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion, Has semicarbazide-sensitive (SSAO) monoamine oxidase activity, May play a role in adipogenesis

Belongs to the copper/topaquinone oxidase family


This is MICOS complex subunit MIC60 protein, from Human, contains 758 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane, Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180)

Belongs to the MICOS complex subunit Mic60 family


This is Protein unc-112 protein, from Caenorhabditis elegans, contains 720 amino acids, is membrane-bound, locates in Cell membrane.

Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611), Probable regulator of cell-extracellular matrix adhesion (PubMed:10893272), Required during initial muscle assembly to form dense bodies and M-lines (PubMed:10893272)


This is Sodium-coupled monocarboxylate transporter 2 protein, from Human, contains 618 amino acids, is membrane-bound, locates in Cell membrane.

Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter (PubMed:17692818), Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate (By similarity), May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine, May play also a role in monocarboxylates transport in the retina (By similarity)

Belongs to the sodium:solute symporter (SSF) (TC 2,A,21) family


This is B-box domain protein 30 protein, from Mouse-ear cress, contains 117 amino acids, has 1 B box-type; atypical Zinc finger, locates in Nucleus.

B box-type; atypical

Developmental regulator acting by forming heterodimeric complexes, that sequester CO and CO-like (COL) proteins into non-functional complexes, Engages CO and the transcriptional repressor TPL in a tripartite complex, Involved in the CO-mediated long-day flowering-promotion pathway


This is Dual oxidase maturation factor 2 protein, from Human, contains 320 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2, May play a role in thyroid hormone synthesis


This is FMRFamide-related peptides protein, from Silk moth, contains 177 amino acids, is soluble, locates in Extracellular.

Regulates ecdysteroidogenesis by direct innervation of the prothoracic gland by reducing cAMP production via the receptor for myosuppressin, The neurons that innervate the prothoracic gland during the fifth instar are most active during days 0-4, after which they reduce and then peak again on day 6, Expression suppresses the biosynthesis of steroid hormones called ecdysteroids that elicit molting and metamorphosis

Belongs to the FARP (FMRFamide related peptide) family


This is ATPase family AAA domain-containing protein 3 protein, from Caenorhabditis elegans, contains 595 amino acids, is membrane-bound, locates in Mitochondrion.

Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level (PubMed:19888333), Important during development for the up-regulation of mitochondrial activity during the transition to higher larval stages (PubMed:19888333), Regulates mitochondrial iron homeostasis (PubMed:26427876), May play an important role in mitochondrial protein synthesis (By similarity), May also participate in mitochondrial DNA replication (By similarity), May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (By similarity), Plays a role in regulating the production of reactive oxygen species in response to heat stress (PubMed:22245785)


This is Tropomyosin isoforms a/b/d/f protein, from Caenorhabditis elegans, contains 284 amino acids, is soluble, locates in Cytoplasm.

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction (PubMed:9113409, PubMed:11901171), Involved in muscle actin filament organization and muscle arm extension and morphology (PubMed:15930100), Protects actin filaments from depolymerization by unc-60 in vitro (PubMed:17684058), Also has a role in male mating behavior by regulating the copulatory spicules (PubMed:16399684), Binds to F-actin (PubMed:11901171)


This is Double-strand break repair protein mre-11 protein, from Caenorhabditis elegans, contains 728 amino acids, locates in Nucleus.

Required for meiotic crossing over and chiasma formation, Pachytene morphology and homolog pairing are normal, Vital in long term for maintenance of reproductive capacity of subsequent generations


This is Sphingomyelin phosphodiesterase 2 protein, from Caenorhabditis elegans, contains 618 amino acids, is soluble, locates in Extracellular.

Sphingomyelin phosphodiesterase (sphingomyelinase) that converts sphingomyelin (N-acyl-sphingoid-1-phosphocholine) to ceramide (N-acyl-sphingoid base) and phosphocholine at acidic pH, Displays its enzymatic activity when secreted, May play distinct roles in signaling

Belongs to the acid sphingomyelinase family


This is 3',5'-cyclic-nucleotide phosphodiesterase regA protein, from Social amoeba, contains 793 amino acids, is soluble, locates in Cytoplasm.

Phosphodiesterase specific for cAMP, Involved in the degradation of intracellular cAMP, Morphological suppressor of tagB, Phosphorelay protein that accepts phosphate from rdeA or supplies phosphate from regA; depending on the relative concentration of the phosphodonor proteins

Belongs to the cyclic nucleotide phosphodiesterase family


This is Nuclear hormone receptor HR78 protein, from Fruit fly, contains 601 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Binds to direct repeats of the sequence 5'-AGGTCA-3', Inhibits the ecdysone response, Plays an essential role in regulating molting of the tracheal cuticle during larval development

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Tropomyosin isoforms c/e protein, from Caenorhabditis elegans, contains 256 amino acids, is soluble, locates in Cytoplasm.

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction, Involved in muscle actin filament organization and muscle arm extension and morphology, Also has a role in male mating behavior by regulating the copulatory spicules, Binds to F-actin


This is Histone H2A.V protein, from Caenorhabditis elegans, contains 140 amino acids, locates in Nucleus.

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity), Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the repression of transcription factor ceh-22 (PubMed:24346701)


This is Nacrein protein, from Akoya pearl oyster, contains 447 amino acids, is soluble, locates in Extracellular.

Acts as a negative regulator for calcification in the shells of mollusks, May function both as a calcium concentrator and as a carbonic anhydrase required for production of carbonate ions, which are assembled to CaCO(3) at mineralization sites, Is important for shell formation in both the calcitic prismatic layer and the aragonitic nacreous layer

Belongs to the alpha-carbonic anhydrase family


This is Centrosomal protein kizuna protein, from Human, contains 673 amino acids, is soluble, locates in Cytoplasm.

Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation, Required for stabilizing the expanded pericentriolar material around the centriole


This is GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase protein, from Human, contains 492 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum, Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain

Belongs to the glycosyltransferase group 1 family, Glycosyltransferase 4 subfamily


This is Leucine aminopeptidase A protein, from Yellow koji mold, contains 377 amino acids, is soluble, locates in Extracellular.

Extracellular aminopeptidase that allows assimilation of proteinaceous substrates

Belongs to the peptidase M28 family, M28E subfamily


This is probable leucine aminopeptidase 2 protein, from Yellow koji mold, contains 496 amino acids, is soluble, locates in Extracellular.

Extracellular aminopeptidase that releases a wide variety of amino acids from natural peptides

Belongs to the peptidase M28 family, M28A subfamily


This is Cyclin-A2-3 protein, from Mouse-ear cress, contains 450 amino acids, locates in Nucleus.

Negatively regulates endocycles and acts as a regulator of ploidy levels in endoreduplication (PubMed:16415207), Promotes divisions in the guard cells (GCs) after the guard mother cells (GMC) symmetric division (PubMed:24687979)

Belongs to the cyclin family, Cyclin AB subfamily


This is Potassium channel AKT2/3 protein, from Mouse-ear cress, contains 802 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Highly selective and weak inward-rectifying potassium channel, Plays a role in both loading and unloading potassium into/from the phloem sap, Seems to control sugar loading into phloem via a voltage-dependent process, Blocked by physiological concentrations of external calcium and by external acidification, May interact with the cytoskeleton or with regulatory proteins, Dephosphorylation by PP2CA not only leads to the inhibition of potassium currents but also to an increase of the voltage-dependence of the channel, Regulated by the CBL4/CIPK6 calcium sensor/protein kinase complex via a kinase interaction-dependent but phosphorylation-independent translocation of the channel to the plasma membrane

Belongs to the potassium channel family, Plant (TC 1,A,1,4) subfamily


This is Potassium channel AKT1 protein, from Mouse-ear cress, contains 857 amino acids, is membrane-bound, locates in Cell membrane.

Highly selective inward-rectifying potassium channel that mediate potassium uptake by plant roots in response to low K(+) conditions, by a calcium-, CBL-, and CIPK-dependent pathway, Positively regulated by phosphorylation by CIPK23, Negatively regulated by a kinase-independent regulatory mechanism involving a competing direct binding of CBL10, Involved in the stomatal regulation by monitoring the turgor pressure in guard cells, Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization, May interact with the cytoskeleton or with regulatory proteins (PubMed:12678562, PubMed:16814720, PubMed:16895985, PubMed:17898163, PubMed:9572739), Is essential with POT5/HAK5 for high-affinity potassium uptake in roots during seedling establishment and postgermination growth under low potassium conditions (PubMed:20413648)


This is Vacuolar-processing enzyme beta-isozyme protein, from Mouse-ear cress, contains 486 amino acids, locates in Lysosome/Vacuole.

Asparagine-specific endopeptidase involved in the processing of vacuolar seed protein precursors into the mature forms (By similarity), Probably involved in post-translational proteolysis of seed storage proteins in the protein storage vacuole of developing seeds (PubMed:12417707, PubMed:14688293)


This is Vacuolar-processing enzyme gamma-isozyme protein, from Mouse-ear cress, contains 494 amino acids, locates in Lysosome/Vacuole.

Asparagine-specific endopeptidase involved in the processing of vacuolar seed protein precursors into the mature forms (PubMed:10417725), Probably involved in post-translational proteolysis of seed storage proteins in the protein storage vacuole of developing seeds (PubMed:14688293)


This is Serine/threonine-protein kinase TOUSLED protein, from Mouse-ear cress, contains 688 amino acids, locates in Nucleus.

Required for correct initiation of floral organ primordia and for proper development of organ primordia, Phosphorylates in vitro ASF1B/SGA1, the C-terminal part of TKI1 and histone H3

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Actin-depolymerizing factor 1 protein, from Mouse-ear cress, contains 139 amino acids, is soluble, locates in Cytoplasm.

Actin-depolymerizing protein, Stimulates F-actin depolymerization, Involved in plant development, cell organ expansion and flowering by controlling breakdown of thick actin cables (PubMed:11402164), Severs actin filaments or bundles and promotes actin cytoskeleton disassembly (PubMed:21570971), Binds monomeric actin (G-actin) with a marked preference for the ADP-loaded form and inhibits the rate of nucleotide exchange on G-actin (PubMed:17538023)

Belongs to the actin-binding proteins ADF family


This is Small ribosomal subunit protein eS21B protein, from Baker's yeast, contains 87 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102), eS21 is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits, Has a physiological role leading to 18S rRNA stability (PubMed:14627813)

Belongs to the eukaryotic ribosomal protein eS21 family


This is Small ribosomal subunit protein eS25A protein, from Baker's yeast, contains 108 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eS25 family


This is V-type proton ATPase subunit e protein, from Baker's yeast, contains 73 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:14594803), V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:14594803)

Belongs to the V-ATPase e1/e2 subunit family


This is Small ribosomal subunit protein eS28A protein, from Baker's yeast, contains 67 amino acids, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eS28 family


This is Phospholipase A1-Igamma2, chloroplastic protein, from Mouse-ear cress, contains 529 amino acids, locates in Plastid.

Acylhydrolase with broad specificity (PubMed:19527719), Catalyzes the hydrolysis of phosphatidylcholine at the sn-1 position (PubMed:19527719), Possesses moderate activity toward phosphatidylcholine (PC), monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and triacylglycerol (TAG) (PubMed:19527719)

Belongs to the AB hydrolase superfamily, Lipase family


This is Protein-tyrosine sulfotransferase protein, from Mouse-ear cress, contains 500 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides


This is Cell cycle control protein 50B protein, from Human, contains 351 amino acids, is membrane-bound, locates in Cell membrane.

Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids, Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules, The beta subunit may assist in binding of the phospholipid substrate (Probable), Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane


This is Mitochondrial 10-formyltetrahydrofolate dehydrogenase protein, from Human, contains 923 amino acids, locates in Mitochondrion.

Mitochondrial 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide

In the C-terminal section; belongs to the aldehyde dehydrogenase family, ALDH1L subfamily