This is Nuclear polyadenylated RNA-binding protein nab2 protein, from Fission yeast, contains 307 amino acids, has 3 C3H1-type Zinc finger, locates in Nucleus.

Binds to polyadenylated RNA and single-stranded DNA, It may be involved not only in RNA processing but also in transcription regulation, Believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions (By similarity)


This is Ceramide very long chain fatty acid hydroxylase scs7 protein, from Fission yeast, contains 347 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids, Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2

Belongs to the sterol desaturase family, SCS7 subfamily


This is Homoisocitrate dehydrogenase protein, from Fission yeast, contains 362 amino acids, is soluble, locates in Cytoplasm.

Belongs to the isocitrate and isopropylmalate dehydrogenases family


This is Alpha-amylase mde5 protein, from Fission yeast, contains 513 amino acids, locates in Endoplasmic reticulum.

Belongs to the glycosyl hydrolase 13 family


This is Pentatricopeptide repeat-containing protein 4, mitochondrial protein, from Fission yeast, contains 931 amino acids, locates in Mitochondrion.

Mitochondrial RNA-binding protein that specifically activates the translation of the cox1 mRNA


This is SAGA complex subunit spt3 protein, from Fission yeast, contains 307 amino acids, locates in Nucleus.

Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA, SAGA is involved in RNA polymerase II-dependent transcriptional regulation, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (spt3, spt8 and spt20) and promoter selectivity, interaction with transcription activators (gcn5, ada2, ada3 and tra1), and chromatin modification through histone acetylation (gcn5) and deubiquitination (ubp8), SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), Spt3 is required for recruitment of TATA-binding protein (TBP) to SAGA-dependent promoters, During SAGA-mediated transcriptional inhibition, spt3 and spt8 prevent binding of TBP to the TATA box (By similarity), SPT factors 3, 7 and 8 are required for the initiation of Ty transcription from the delta promoter, Spt3 regulates Ty1 as well as the mating factor genes


This is Thylakoid lumenal 15 kDa protein 1, chloroplastic protein, from Mouse-ear cress, contains 224 amino acids, locates in Plastid.


This is Arogenate dehydratase 4, chloroplastic protein, from Mouse-ear cress, contains 424 amino acids, is soluble, locates in Plastid.

Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine


This is Preprotein translocase subunit SECE1 protein, from Mouse-ear cress, contains 177 amino acids, is membrane-bound, locates in Plastid.

Involved in the import/insertion pathway in the thylakoids, The signal recognition particle is not involved in the insertion of SECE1 in the thylakoid membrane


This is Isopentenyl-diphosphate Delta-isomerase 1 protein, from Golden hamster, contains 227 amino acids, locates in Peroxisome.

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)

Belongs to the IPP isomerase type 1 family


This is Corticotropin-releasing factor receptor 1 protein, from African clawed frog, contains 415 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin), Has high affinity for CRH and UCN, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase, Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels

Belongs to the G-protein coupled receptor 2 family


This is Pentatricopeptide repeat-containing protein 3, mitochondrial protein, from Fission yeast, contains 687 amino acids, locates in Mitochondrion.

RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts, Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome


This is Arrestin family protein 1 protein, from Fission yeast, contains 483 amino acids, is soluble, locates in Cytoplasm.


This is Sterol-4-alpha-carboxylate 3-dehydrogenase erg26, decarboxylating protein, from Fission yeast, contains 340 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Sterol-4-alpha-carboxylate 3-dehydrogenase; part of the third module of ergosterol biosynthesis pathway that includes by the late steps of the pathway (By similarity), Erg26 is a catalytic component of the C-4 demethylation complex that catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group (By similarity), The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane, Firstly, the squalene synthase erg9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids, Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase erg1 and the lanosterol synthase erg7, The lanosterol 14-alpha-demethylase erg11/cyp1 catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, In the next steps, a complex process involving various demethylation, reduction and desaturation reactions catalyzed by the C-14 reductase erg24 and the C-4 demethylation complex erg25-erg26-erg27 leads to the production of zymosterol, Erg28 likely functions in the C-4 demethylation complex reaction by tethering erg26 and Erg27 to the endoplasmic reticulum or to facilitate interaction between these proteins, Then, the sterol 24-C-methyltransferase erg6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol, The C-8 sterol isomerase erg2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol, The sterol-C5-desaturases erg31 and erg32 then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol, The C-22 sterol desaturase erg5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain, Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase erg4 to produce ergosterol (PubMed:18310029) (Probable), In the genus Schizosaccharomyces, a second route exists between lanosterol and fecosterol, via the methylation of lanosterol to eburicol by erg6, followed by C14-demethylation by erg11/cyp1 and C4-demethylation by the demethylation complex erg25-erg26-erg27 (PubMed:8586261) (Probable)


This is Pre-mRNA-processing factor 17 protein, from Fission yeast, contains 558 amino acids, locates in Nucleus.

Functions in the second step of pre-mRNA splicing, Involved in splicing intron which are longer than 200 nucleotides


This is Potassium channel toxin alpha-KTx 10.1 protein, from Mexican scorpion, contains 62 amino acids, is soluble, locates in Extracellular.

Blocks Shaker B (Sh) and voltage-gated potassium-channels Kv1,1/KCNA1, Kv1,2/KCNA2, Kv1,3/KCNA3, Also inhibits small conductance calcium-activated potassium channels (KCNN) and intermediate conductance calcium-activated potassium channel (KCa3,1/KCNN4)

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 10 subfamily


This is Cytochrome b5 isoform B protein, from Mouse-ear cress, contains 134 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases, including fatty acid desaturases


This is Dihydroceramide fatty acyl 2-hydroxylase FAH1 protein, from Mouse-ear cress, contains 237 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Fatty acid 2-hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long-chain fatty acids (VLCFA), Probably involved in the resistance response to oxidative stress


This is Actin-depolymerizing factor 9 protein, from Mouse-ear cress, contains 141 amino acids, is soluble, locates in Cytoplasm.

Does not display typical F-actin depolymerizing activity, Exhibits a high ability to stabilize and cross-link actin filaments, Functions as an actin bundling protein with the highest efficiency under acidic conditions (PubMed:21570971), May play a role in the modulation of levels of histone H3 lysine 4 trimethylation and H3 lysine 9 and 14 acetylation at the FLC locus (PubMed:18830798)

Belongs to the actin-binding proteins ADF family


This is Fibroblast growth factor 16 protein, from Rat, contains 207 amino acids, is soluble, locates in Extracellular.

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development

Belongs to the heparin-binding growth factors family


This is Carboxypeptidase Z protein, from Rat, contains 652 amino acids, is soluble, locates in Extracellular.

Cleaves substrates with C-terminal arginine residues, Probably modulates the Wnt signaling pathway, by cleaving some undefined protein, May play a role in cleavage during prohormone processing (By similarity)


This is Serine/threonine-protein kinase ppk25 protein, from Fission yeast, contains 423 amino acids, is soluble, locates in Cytoplasm.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Pre-mRNA-splicing factor cwf5 protein, from Fission yeast, contains 354 amino acids, locates in Nucleus.

Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, Binds to RNA (By similarity), Involved in pre-mRNA splicing


This is Thioredoxin-like 1-1, chloroplastic protein, from Mouse-ear cress, contains 275 amino acids, locates in Plastid.

Thiol-disulfide oxidoreductase that may participate in various redox reactions, Possesses insulin disulfide bonds reducing activity


This is SWIRM domain-containing protein laf2 protein, from Fission yeast, contains 272 amino acids, locates in Nucleus.

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events


This is Transcription initiation factor TFIID subunit 6 protein, from Fission yeast, contains 452 amino acids, locates in Nucleus.

TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription


This is Vacuolar morphogenesis protein 7 homolog protein, from Fission yeast, contains 341 amino acids, locates in Lysosome/Vacuole.

Essential for proper morphogenesis of the vacuole, May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure (By similarity)


This is DNA primase large subunit protein, from Fission yeast, contains 459 amino acids, locates in Nucleus.

Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (By similarity), During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit pol1, an accessory subunit spb70/pol12 and two primase subunits, the catalytic subunit spp1/pri1 and the regulatory subunit spp2/pri2) is recruited to DNA at the replicative forks (By similarity), The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity)

Belongs to the eukaryotic-type primase large subunit family


This is Tyrosine--tRNA ligase, mitochondrial protein, from Fission yeast, contains 445 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)

Belongs to the class-I aminoacyl-tRNA synthetase family


This is Chromatin structure-remodeling complex subunit rsc1 protein, from Fission yeast, contains 803 amino acids, locates in Nucleus.

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, Controls particularly membrane and organelle development genes


This is Breast carcinoma-amplified sequence 1 protein, from Human, contains 584 amino acids, is soluble, locates in Cytoplasm.


This is UBP1-associated protein 2B protein, from Mouse-ear cress, contains 451 amino acids, locates in Nucleus.

Heterogeneous nuclear ribonucleoprotein (hnRNP)-like protein that acts as component of a complex regulating the turnover of mRNAs in the nucleus, Binds with high affinity to RNA molecules that contain U-rich sequences in 3'-UTRs, May function in complex with UBP1 and contribute to the stabilization of mRNAs in the nucleus (By similarity)


This is LIM domain-containing protein PLIM2a protein, from Mouse-ear cress, contains 226 amino acids, is soluble, locates in Cytoplasm.

Binds to actin filaments and promotes cross-linking into thick bundles, Has an actin-stabilizing activity, The actin regulatory activities are inhibited by pH > 6,8 but are [Ca(2+)] independent


This is Hydroxymethylglutaryl-CoA lyase, mitochondrial protein, from Mouse-ear cress, contains 468 amino acids, is soluble, locates in Mitochondrion.

Involved in the catabolism of branched amino acids such as leucine


This is Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial protein, from Mouse-ear cress, contains 368 amino acids, locates in Mitochondrion.

Performs an essential role in the oxidative function of the citric acid cycle


This is Probable plastid-lipid-associated protein 3, chloroplastic protein, from Mouse-ear cress, contains 376 amino acids, is soluble, locates in Plastid.

Probably involved in light/cold stress-related jasmonate (JA) biosynthesis


This is Sphingoid long-chain bases kinase 2, mitochondrial protein, from Mouse-ear cress, contains 364 amino acids, locates in Mitochondrion.

Involved in the production of sphingoid long-chain base (LCB), Is required for the cold-induced accumulation of phytosphingosine-phosphate, the regulation of the cold-responsive MPK6 and reduction of root growth at moderate low temperature


This is Ribonucleases P/MRP protein subunit POP7 protein, from Fission yeast, contains 102 amino acids, locates in Nucleus.

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends, Also a component of RNase MRP, which cleaves pre-rRNA sequences (By similarity)


This is Probable E3 ubiquitin-protein ligase mug30 protein, from Fission yeast, contains 807 amino acids, is soluble, locates in Cytoplasm.

Probable E3 ubiquitin-protein ligase, Has a role in meiosis


This is Zinc-regulated transporter 1 protein, from Fission yeast, contains 408 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

High-affinity zinc transport protein, Regulates intracellular zinc levels

Belongs to the ZIP transporter (TC 2,A,5) family


This is CENP-A recruiting complex protein mis20 protein, from Fission yeast, contains 253 amino acids, is soluble, locates in Cytoplasm.

Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A (PubMed:24774534, PubMed:24789708), Seems dispensable for proper chromosome segregation (PubMed:24774534)


This is Enhancer of mRNA-decapping protein 3 protein, from Fission yeast, contains 454 amino acids, is soluble, locates in Cytoplasm.

Stimulates decapping of both stable and unstable mRNA during mRNA decay, Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation


This is Angiopoietin-related protein 1 protein, from Human, contains 491 amino acids, is soluble, locates in Extracellular.


This is Corticoliberin protein, from Sheep, contains 190 amino acids, is soluble, locates in Extracellular.

Hormone regulating the release of corticotropin from pituitary gland (PubMed:6267699, PubMed:6273874), Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity)

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family


This is Partitioning protein REP2 protein, from Baker's yeast, contains 296 amino acids, locates in Nucleus.

Part of the plasmid partitioning system, which ensures the equal distribution of replicated plasmid molecules to daughter cells, The plasmids exist as well-organized plasmid foci within the nucleus that stay together throughout the cell-cycle and act as entity during segregation, effetively reducing copy number to one, Plasmid partitioning requires the proteins REP1, REP2, and a cis-acting locus STB (REP3), REP1-REP2 stably associate with CSE4-containing chromatin at STB during S-phase, marking the locus with a centromeric tag, and thereby probably catching mitotic spindle microtubules to the plasmid cluster and coupling plasmid segregation to chromosome segregation, REP1-REP2 are required to recruit the cohesin complex to the STB locus for pairing of the replicated plasmid cluster, a prerequisite for successful plasmid segregation, REP1-REP2 also negatively regulate expression of site-specific recombinase FLP and of RAF1


This is Serum amyloid A-1 protein protein, from Mouse, contains 122 amino acids, is soluble, locates in Extracellular.


This is Large ribosomal subunit protein eL29 protein, from Baker's yeast, contains 59 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL29 family


This is Mitochondrial RNA-splicing protein MRS1 protein, from Baker's yeast, contains 363 amino acids, is soluble, locates in Mitochondrion.

Function in mitochondrial RNA splicing in the excision of mitochondrial group I introns aI5 beta from COX1 and bI3 from COB transcripts and thus would be involved in obtaining the correct structure of the intron, to allow the RNA catalyzed reactions to occur


This is Serendipity locus protein beta protein, from Fruit fly, contains 356 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 5 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

Binds to the consensus DNA sequence 5'-YCAGAGATGCGCA-3'


This is Brevinin-1DYb protein, from Dybovsky's frog, contains 66 amino acids, is soluble, locates in Extracellular.

Antimicrobial peptide, Has low activity against the Gram-positive bacterium S,aureus and the Gram-negative bacterium E,coli (MIC<15 uM), Has a strong hemolytic activity

Belongs to the frog skin active peptide (FSAP) family, Brevinin subfamily


This is WAS/WASL-interacting protein family member 3 protein, from Mouse, contains 485 amino acids, is soluble, locates in Cytoplasm.

May be a regulator of cytoskeletal organization (Potential), May have a role in spermatogenesis


This is Centrosomal protein of 63 kDa protein, from Chicken, contains 711 amino acids, is soluble, locates in Cytoplasm.

Required for normal spindle assembly, Plays a key role in mother-centriole-dependent centriole duplication (PubMed:19182792), Plays a role in DNA damage response (PubMed:19182792), Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:19182792)


This is 4-O-methyl-glucuronoyl methylesterase 1 protein, from White-rot fungus, contains 472 amino acids, is soluble, locates in Extracellular.

Glucuronoyl esterase which may play a significant role in biomass degradation, as it is considered to disconnect hemicellulose from lignin through the hydrolysis of the ester bond between 4-O-methyl-D-glucuronic acid residues of glucuronoxylans and aromatic alcohols of lignin (PubMed:18854978, PubMed:19897892), Can hydrolyze benzyl glucuronic acid (BnGlcA), allyl glucuronic acid (allylGlcA) and to a lower degree methyl glucuronic acid (MeGlcA) in vitro (PubMed:28429057)

Belongs to the carbohydrate esterase 15 (CE15) family


This is 4-O-methyl-glucuronoyl methylesterase 2 protein, from White-rot fungus, contains 407 amino acids, is soluble, locates in Extracellular.

Glucuronoyl esterase which may play a significant role in biomass degradation, as it is considered to disconnect hemicellulose from lignin through the hydrolysis of the ester bond between 4-O-methyl-D-glucuronic acid residues of glucuronoxylans and aromatic alcohols of lignin


This is Mu-scoloptoxin(03)-Ssm2a protein, from Chinese red-headed centipede, contains 112 amino acids, is soluble, locates in Extracellular.

Gating-modifier toxin that inhibits voltage-gated sodium channel with a preference for hNav1,7/SCN9A (IC(50)=25,4 nM) over hNav1,1/SCN1A (IC(50)=4,1 uM), hNav1,2/SCN2A (IC(50)=813 nM), and hNav1,6/SCN8A (IC(50)=15,2 uM) (PubMed:24082113), Is an effective analgesic in rodent pain models, since it is several-fold more effective than morphine in a rodent model of formalin-induced pain and is equipotent with morphine in its ability to reduce thermal and acid-induced pain (PubMed:24082113), In addition, this peptide shows a high level of resistance to proteases and a high thermal stability that may be explained by its predominant composition of alpha-helices (PubMed:24082113)


This is Plastocyanin minor isoform, chloroplastic protein, from Mouse-ear cress, contains 171 amino acids, is membrane-bound, locates in Plastid.

Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I, Seems to be a minor plastocyanin in Arabidopsis


This is Oxygen-evolving enhancer protein 1, chloroplastic protein, from Spinach, contains 332 amino acids, is membrane-bound, locates in Plastid.

Stabilizes the manganese cluster which is the primary site of water splitting (By similarity), Binds GTP after preillumination of photosystem II core complex, This binding is inhibited by DCMU


This is Patatin-T5 protein, from Potato, contains 386 amino acids, locates in Lysosome/Vacuole.

Probable lipolytic acyl hydrolase (LAH), an activity which is thought to be involved in the response of tubers to pathogens


This is Solute carrier family 25 member 16 protein, from Human, contains 332 amino acids, is membrane-bound, locates in Mitochondrion.

May be involved in the transport of coenzyme A in the mitochondrial matrix (PubMed:11158296), Very little is known about the physiological function of this carrier (PubMed:11158296)

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Alpha-amylase 1 protein, from Yeast, contains 512 amino acids, is soluble, locates in Extracellular.


This is Large ribosomal subunit protein uL30m protein, from Baker's yeast, contains 86 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the universal ribosomal protein uL30 family


This is Small ribosomal subunit protein uS15m protein, from Baker's yeast, contains 286 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uS15 family


This is Small ribosomal subunit protein eS1B protein, from Baker's yeast, contains 255 amino acids, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eS1 family


This is Large ribosomal subunit protein mL59 protein, from Baker's yeast, contains 157 amino acids, locates in Mitochondrion.

Belongs to the mitochondrion-specific ribosomal protein mL59 family


This is Glucan endo-1,3-beta-glucosidase protein, from Common tobacco, contains 351 amino acids, is soluble, locates in Extracellular.

Implicated in the defense of plants against pathogens

Belongs to the glycosyl hydrolase 17 family


This is Dihydrosphingosine 1-phosphate phosphatase YSR3 protein, from Baker's yeast, contains 404 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases (PubMed:10477278, PubMed:10563329, PubMed:10856228, PubMed:9353337, PubMed:9419344), Involved in endocytosis and calcium-mediated signaling (PubMed:10856228)

Belongs to the type 2 lipid phosphate phosphatase family


This is Parathyroid hormone/parathyroid hormone-related peptide receptor protein, from North American opossum, contains 585 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for parathyroid hormone and for parathyroid hormone-related peptide, The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system

Belongs to the G-protein coupled receptor 2 family


This is 2-hydroxy-palmitic acid dioxygenase MPO1 protein, from Baker's yeast, contains 174 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Dioxygenase that catalyzes the alpha-oxidation of 2-hydroxy fatty acids in an iron-dependent manner (PubMed:30530523), Involved in metabolism of phytosphingosine and is required for proper endoplasmic reticulum stress response (PubMed:25345524, PubMed:30530523)


This is Protein PER1 protein, from Baker's yeast, contains 357 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the lipid remodeling steps of GPI-anchor maturation, Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins, Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI, Required for efficient transport of GPI-anchor proteins


This is Large ribosomal subunit protein bL19m protein, from Baker's yeast, contains 169 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:24675956), bL19m is essential for respiration (PubMed:8771712)

Belongs to the bacterial ribosomal protein bL19 family


This is RYamide receptor protein, from Fruit fly, contains 464 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for the neuropeptides RYamide-1 and RYamide-2 (PubMed:21843505, PubMed:21704020), The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system (PubMed:21843505, PubMed:21704020), RYamide signaling may suppress feeding behavior (PubMed:21704020)

Belongs to the G-protein coupled receptor 1 family


This is Large ribosomal subunit protein cL37 alpha protein, from Spinach, contains 142 amino acids, locates in Plastid.

Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus

Belongs to the chloroplast-specific ribosomal protein cL37 family


This is Small ribosomal subunit protein uS4m protein, from Baker's yeast, contains 486 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uS4 family


This is Trypsin 3A1 protein, from Yellowfever mosquito, contains 254 amino acids, is soluble, locates in Extracellular.

Major function may be to aid in digestion of the blood meal


This is CD9 antigen protein, from Green monkey, contains 228 amino acids, is membrane-bound, locates in Cell membrane.

Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity), Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity), In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity), In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity), Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity), Acts as a receptor for PSG17 (By similarity), Involved in platelet activation and aggregation (By similarity), Regulates paranodal junction formation (By similarity), Involved in cell adhesion, cell motility and tumor metastasis (By similarity)

Belongs to the tetraspanin (TM4SF) family


This is Globin-like protein protein, from Caenorhabditis elegans, contains 159 amino acids, is soluble, locates in Cytoplasm.

May be a globin and may play a role in oxygen transport


This is Vasopressin V2 receptor protein, from Pig, contains 370 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for arginine vasopressin, The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:8393786), Involved in renal water reabsorption (By similarity)

Belongs to the G-protein coupled receptor 1 family, Vasopressin/oxytocin receptor subfamily


This is GABA-specific permease protein, from Baker's yeast, contains 571 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Required for high-affinity, high-specificity GABA transport, Also transports putrescine

Belongs to the amino acid-polyamine-organocation (APC) superfamily, Amino acid/choline transporter (ACT) (TC 2,A,3,4) family


This is Ammonia transport outward protein 2 protein, from Baker's yeast, contains 282 amino acids, is membrane-bound, locates in Cell membrane.

Transporter protein required for ammonia export, Involved in acetate resistance

Belongs to the acetate uptake transporter (AceTr) (TC 2,A,96) family


This is Intrastrand cross-link recognition protein protein, from Baker's yeast, contains 597 amino acids, locates in Nucleus.

Binds to platinated DNA and confers sensitivity to the anticancer drug cisplatin, Activate the expression of the COX5B gene


This is Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial protein, from Baker's yeast, contains 541 amino acids, locates in Mitochondrion.

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria, The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)

Belongs to the GatB/GatE family, GatB subfamily


This is Trypsin-1 protein, from African malaria mosquito, contains 274 amino acids, is soluble, locates in Extracellular.


This is Trypsin-2 protein, from African malaria mosquito, contains 277 amino acids, is soluble, locates in Extracellular.


This is Trypsin-3 protein, from African malaria mosquito, contains 275 amino acids, is soluble, locates in Extracellular.

Constitutive trypsin that is expressed 2 days after emergence, coinciding with host seeking behavior of the female


This is Trypsin-4 protein, from African malaria mosquito, contains 275 amino acids, is soluble, locates in Extracellular.


This is Trypsin-5 protein, from African malaria mosquito, contains 274 amino acids, is soluble, locates in Extracellular.


This is Trypsin-6 protein, from African malaria mosquito, contains 273 amino acids, is soluble, locates in Extracellular.


This is Trypsin-7 protein, from African malaria mosquito, contains 267 amino acids, is soluble, locates in Extracellular.


This is Endoplasmic reticulum transmembrane protein 1 protein, from Baker's yeast, contains 206 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi


This is 3-oxoacyl-[acyl-carrier-protein] reductase protein, from Baker's yeast, contains 278 amino acids, locates in Mitochondrion.

Involved in biosynthesis of fatty acids in mitochondria

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Elongation factor 1-gamma 2 protein, from Baker's yeast, contains 412 amino acids, is soluble, locates in Cytoplasm.

Subunit of the eukaryotic elongation factor 1 complex (eEF1), Probably plays a role in anchoring the complex to other cellular components (By similarity)


This is Vacuolar amino acid transporter 3 protein, from Baker's yeast, contains 692 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Involved in amino acid efflux from the vacuole to the cytoplasm, Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine

Belongs to the amino acid/polyamine transporter 2 family


This is Ribosomal RNA-processing protein 14 protein, from Baker's yeast, contains 434 amino acids, locates in Nucleus.

Involved in ribosome biogenesis and cell polarity, Required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis


This is Mannan endo-1,6-alpha-mannosidase DCW1 protein, from Baker's yeast, contains 449 amino acids, is membrane-bound, locates in Cell membrane.

Required for normal synthesis of the cell wall

Belongs to the glycosyl hydrolase 76 family


This is Large ribosomal subunit protein uL29m protein, from Baker's yeast, contains 319 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the universal ribosomal protein uL29 family


This is Large ribosomal subunit protein bL33m protein, from Baker's yeast, contains 70 amino acids, locates in Mitochondrion.

Belongs to the bacterial ribosomal protein bL33 family


This is Cell division control protein 16 protein, from Fission yeast, contains 299 amino acids, is soluble, locates in Cytoplasm.

Has a dual role in the cell cycle, In mitosis, it is involved in maintenance of cdc2 kinase activity, It is subsequently required for regulation of septum formation, Could be involved in maintenance of cdc2 kinase activity by preventing, directly or indirectly, the degradation of cyclin or the dephosphorylation of 'Thr-167' of cdc2


This is Large ribosomal subunit protein uL16m protein, from Baker's yeast, contains 232 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uL16 family


This is Pachytene checkpoint protein 2 protein, from Baker's yeast, contains 564 amino acids, locates in Nucleus.

Required for the pachytene checkpoint, the meiotic checkpoint that prevents chromosome segregation when defects in recombination and synaptonemal complex formation occurred, Represses meiotic recombination in the rDNA, probably by excluding the meiosis-specific protein HOP1 from the nucleolar region

Belongs to the AAA ATPase family, PCH2 subfamily


This is Protein transport protein SFT2 protein, from Baker's yeast, contains 215 amino acids, is membrane-bound, locates in Golgi apparatus.

Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex, Can be partially replaced by GOT1


This is Small ribosomal subunit protein bS21m protein, from Baker's yeast, contains 177 amino acids, locates in Mitochondrion.

Belongs to the bacterial ribosomal protein bS21 family


This is RNA polymerase I-specific transcription initiation factor RRN10 protein, from Baker's yeast, contains 145 amino acids, locates in Nucleus.

Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex, Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level


This is Structure-specific endonuclease subunit SLX1 protein, from Baker's yeast, contains 304 amino acids, has 1 SLX1-type Zinc finger, locates in Nucleus.

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination, Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA, Has a preference for simple Y, 5'-flap and replication fork-like structures, It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates, Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks, Has Holliday junction resolvase activity in vitro


This is Protein-lysine N-methyltransferase EFM2 protein, from Baker's yeast, contains 419 amino acids, is soluble, locates in Cytoplasm.

S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 2 (EFT1/EFT2) at 'Lys-613' and methylates elongation factor 3A (YEF3)

Belongs to the class I-like SAM-binding methyltransferase superfamily, METTL21 family


This is Protein BIG1 protein, from Baker's yeast, contains 335 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for normal beta-1,6-glucan synthesis


This is Chromosome transmission fidelity protein 8 protein, from Baker's yeast, contains 133 amino acids, locates in Nucleus.

Essential for the fidelity of chromosome transmission, Required for the DNA replication block checkpoint, Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA, During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC, The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit, Dissociation of RFC from the clamp leaves the clamp encircling DNA


This is Mitochondrial distribution and morphology protein 31 protein, from Baker's yeast, contains 579 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria, Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures


This is Protein SOP4 protein, from Baker's yeast, contains 234 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the export of PMA1, possibly through the monitoring or assisting of PMA1 folding and acquisition of competence to enter vesicles


This is Single-strand annealing weakened protein 1 protein, from Baker's yeast, contains 261 amino acids, locates in Nucleus.

Catalyzes 3'-non-homologous tail removal of RAD1/RAD10-dependent single-strand annealing recombination intermediates, Plays a key role in targeting RAD1/RAD10 complex to 3'-flap cleavage substrate in recombination, Also contributes to the integrity of ribosomal DNA arrays


This is CD9 antigen protein, from Cat, contains 226 amino acids, is membrane-bound, locates in Cell membrane.

Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity), Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity), In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity), In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity), Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity), Acts as a receptor for PSG17 (By similarity), Involved in platelet activation and aggregation (By similarity), Regulates paranodal junction formation (By similarity), Involved in cell adhesion, cell motility and tumor metastasis (By similarity)


This is Transcriptional activator POG1 protein, from Baker's yeast, contains 351 amino acids, locates in Nucleus.

Transcriptional activator which promotes cell cycle recovery with CLN2, after pheromone induced G1 arrest, probably inhibiting the ability of STE20 to activate the pheromone response pathway, Binds the promoters of genes that function in cell cycle regulation, cytoskeletal organization, and spindle assembly, May also be involved in stress-resistance


This is Quinidine resistance protein 2 protein, from Baker's yeast, contains 542 amino acids, is membrane-bound, locates in Cell membrane.

Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate), Implicated in potassium uptake

Belongs to the major facilitator superfamily, CAR1 family


This is Quinidine resistance protein 1 protein, from Baker's yeast, contains 563 amino acids, is membrane-bound, locates in Cell membrane.

Multidrug resistance transporter involved in resistance and adaptation to quinidine and ketoconazole


This is Protein SHQ1 protein, from Baker's yeast, contains 507 amino acids, locates in Nucleus.

Involved in the early biogenesis steps of box H/ACA snoRNP assembly


This is Large ribosomal subunit protein bL21m protein, from Baker's yeast, contains 161 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the bacterial ribosomal protein bL21 family


This is Small ribosomal subunit protein uS14A protein, from Baker's yeast, contains 56 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the universal ribosomal protein uS14 family


This is Small ribosomal subunit protein uS14B protein, from Baker's yeast, contains 56 amino acids, is soluble, locates in Cytoplasm.


This is Bud site selection protein 8 protein, from Baker's yeast, contains 603 amino acids, is membrane-bound, locates in Cell membrane.

May be involved in positioning the distal bud pole signal


This is G-box-binding factor 3 protein, from Mouse-ear cress, contains 382 amino acids, locates in Nucleus.

Binds to the G-box motif (5'-CCACGTGG-3') of the rbcS-1A gene promoter, G-box and G-box-like motifs are cis-acting elements defined in promoters of certain plant genes which are regulated by such diverse stimuli as light-induction or hormone control


This is Xylulose kinase protein, from Baker's yeast, contains 600 amino acids, is soluble, locates in Cytoplasm.

Xylulose kinase necessary for growth in culture media with D-xylulose as the solecarbon source


This is Sigma-like sequence protein 1, mitochondrial protein, from Baker's yeast, contains 643 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in aerobic respiration where it is required for assembly of respiratory chain enzyme complexes III and IV, Also has a role in mitochondrial gene expression, May be part of a mitochondrial membrane-associated RNA-shuttling system, delivering NAM1-associated transcripts to the translation machinery


This is SWI/SNF global transcription activator complex subunit SWP82 protein, from Baker's yeast, contains 623 amino acids, locates in Nucleus.

Involved in transcriptional activation, Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes, It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors

Belongs to the RSC7/SWP82 family, SWP82 subfamily


This is ISWI one complex protein 3 protein, from Baker's yeast, contains 787 amino acids, locates in Nucleus.

Functions as component of the ISW1A complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA, The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome


This is Small ribosomal subunit protein eS10B protein, from Baker's yeast, contains 105 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102), eS10 plays a role as a positive regulator of the GCN2 kinase activity by stimulating GCN1-mediated GCN2 activation (PubMed:25437641)

Belongs to the eukaryotic ribosomal protein eS10 family


This is Protein BTN1 protein, from Baker's yeast, contains 408 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Plays a role in vacuolar arginine transport, Involved in pH homeostasis, May be involved in ion homeostasis together with IST2, Not necessary for mitochondrial function or ATP synthase degradation


This is Methylthioribulose-1-phosphate dehydratase protein, from Baker's yeast, contains 244 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P)

Belongs to the aldolase class II family, MtnB subfamily


This is Small ribosomal subunit protein uS7m protein, from Baker's yeast, contains 247 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uS7 family


This is Ribosome biogenesis protein ENP2 protein, from Baker's yeast, contains 707 amino acids, locates in Nucleus.

May be involved in rRNA-processing and ribosome biosynthesis

Belongs to the WD repeat NOL10/ENP2 family


This is Glutathione S-transferase omega-like 1 protein, from Baker's yeast, contains 356 amino acids, locates in Peroxisome.

Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB)

Belongs to the GST superfamily, Omega family


This is Tyrosine--tRNA ligase, mitochondrial protein, from Baker's yeast, contains 492 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)

Belongs to the class-I aminoacyl-tRNA synthetase family


This is Vacuolar-processing enzyme alpha-isozyme protein, from Mouse-ear cress, contains 478 amino acids, locates in Lysosome/Vacuole.

Asparagine-specific endopeptidase involved in the processing of vacuolar seed protein precursors into the mature forms (PubMed:7579169), Probably involved in post-translational proteolysis of seed storage proteins in the protein storage vacuole of developing seeds (PubMed:14688293)


This is Large ribosomal subunit protein bL19m protein, from Human, contains 292 amino acids, locates in Mitochondrion.

Belongs to the bacterial ribosomal protein bL19 family


This is Vacuolar amino acid transporter 4 protein, from Baker's yeast, contains 713 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Involved in amino acid efflux from the vacuole to the cytoplasm, Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine

Belongs to the amino acid/polyamine transporter 2 family


This is Mitochondrial translation optimization protein 1 protein, from Baker's yeast, contains 669 amino acids, locates in Mitochondrion.

Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs


This is Outer spore wall assembly protein SHE10 protein, from Baker's yeast, contains 577 amino acids, locates in Mitochondrion.

Involved in spore wall assembly (PubMed:23966878), May be a component of the mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease involved in the cleaving RNA transcripts to generate primers for DNA replication in mitochondria (PubMed:20086051), Causes growth arrest when highly overexpressed (PubMed:7762298)


This is Meiotic nuclear division protein 1 protein, from Baker's yeast, contains 219 amino acids, locates in Nucleus.

Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis, Stimulates DMC1-dependent homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks


This is Ribosome biogenesis protein NSA1 protein, from Baker's yeast, contains 463 amino acids, locates in Nucleus.

Involved in the biogenesis of the 60S ribosomal subunit


This is Pheromone-regulated membrane protein 8 protein, from Baker's yeast, contains 237 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May be involved in endoplasmic reticulum exit trafficking of proteins


This is Mitochondrial import inner membrane translocase subunit TIM21 protein, from Baker's yeast, contains 239 amino acids, is membrane-bound, locates in Mitochondrion.

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane, Required to keep the TOM and the TIM23 complexes in close contact, At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix, In the complex, it acts as an antagonist of TIM50 by reducing preprotein accumulation at the TOM23 complex and promotes dissociation of the PAM complex from the TIM23 complex


This is GTPase-activating protein GYP2 protein, from Baker's yeast, contains 950 amino acids, is soluble, locates in Cytoplasm.

Stimulates specifically the GTPase activity of SEC4, YPT6 and YPT36, Inactivates YPT6 during recycling between the endosome and the Golgi compartments


This is Cytochrome oxidase assembly protein SHY1 protein, from Baker's yeast, contains 389 amino acids, is membrane-bound, locates in Mitochondrion.

Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane, Involved in a step that couples MSS51-COX14-dependent regulation of COX1 translation to early steps of cytochrome c oxidase assembly


This is RNA polymerase I-specific transcription initiation factor RRN9 protein, from Baker's yeast, contains 365 amino acids, locates in Nucleus.

Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex, Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level


This is Acid alpha-amylase protein, from Aspergillus niger, contains 484 amino acids, is soluble, locates in Extracellular.

Belongs to the glycosyl hydrolase 13 family


This is Potassium channel toxin alpha-KTx 12.1 protein, from Brazilian scorpion, contains 62 amino acids, is soluble, locates in Extracellular.

Potently blocks Kv1,3/KCNA3, Kv1,2/KCNA2, and Shaker potassium channels (PubMed:24590385) and inhibits high conductance calcium-activated potassium channels (PubMed:10082164), Is potent against Kv1,3/KCNN3 (IC(50)=0,55 nM) and Kv1,2/KCNN2 (IC(50)=6,19 nM) (PubMed:24590385), It also stimulates the release of NO, IL-6 and TNF-alpha in J774,1 cells and presents a pro-inflammatory activity in mice (PubMed:21549737, PubMed:23085190)

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 12 subfamily


This is Thrombin-like enzyme bothrombin protein, from Jararaca, contains 232 amino acids, is soluble, locates in Extracellular.

Thrombin-like snake venom serine protease that clots fibrinogen by releasing fibrinopeptide A from the alpha chain of fibrinogen (FGA), induces platelet aggregation through its interaction with GPIb (GP1BA/GP1BB), and activates factor VIII (F8)

Belongs to the peptidase S1 family, Snake venom subfamily


This is Large ribosomal subunit protein bL19c protein, from Spinach, contains 233 amino acids, locates in Plastid.

Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus


This is PsbP domain-containing protein 5, chloroplastic protein, from Mouse-ear cress, contains 297 amino acids, locates in Plastid.


This is Peptidyl-prolyl cis-trans isomerase CYP37, chloroplastic protein, from Mouse-ear cress, contains 466 amino acids, locates in Plastid.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)


This is Pectinesterase inhibitor protein, from Kiwi, contains 185 amino acids, is soluble, locates in Cytoplasm.

Inhibits pectin methylesterase; may be involved in the regulation of fruit ripening


This is Spodomicin protein, from Egyptian cotton leafworm, contains 40 amino acids, is soluble, locates in Extracellular.


This is Alkaline phosphatase protein, from Atlantic cod, contains 477 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the alkaline phosphatase family


This is U7-hexatoxin-Mg1a protein, from Japanese funnel web spider, contains 82 amino acids, is soluble, locates in Extracellular.

Induces flaccid paralysis when injected into lepidopteran larvae, Intracranial injection into mice causes awkwardness of movement and laboured respiration until death


This is Molt-inhibiting hormone protein, from Spinycheek crayfish, contains 106 amino acids, is soluble, locates in Extracellular.

Inhibits Y-organs where molting hormone (ecdysteroid) is secreted, A molting cycle is initiated when MIH secretion diminishes or stops

Belongs to the arthropod CHH/MIH/GIH/VIH hormone family


This is Acetyl-CoA hydrolase protein, from Yeast, contains 524 amino acids, is soluble, locates in Cytoplasm.

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation

Belongs to the acetyl-CoA hydrolase/transferase family


This is Adenosylhomocysteinase protein, from Yeast, contains 450 amino acids, is soluble, locates in Cytoplasm.

Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine

Belongs to the adenosylhomocysteinase family


This is Omega-ctenitoxin-Pr1a protein, from Brazilian Amazonian armed spider, contains 43 amino acids, is soluble, locates in Extracellular.

Inhibits high-voltage activated calcium channels, Shifts the voltage-dependence for activation towards hyperpolarized membrane potentials for L- (Cav1), P/Q- (Cav2,1/CACNA1A) and R-type (Cav2,3/CACNA1E) calcium currents, Causes immediate agitation and clockwise gyration, followed by the gradual development of general flaccid paralysis when injected intracerebroventricular into mice at dose levels of 5 ug per mouse

Belongs to the neurotoxin 02 (plectoxin) family


This is Sterol O-acyltransferase 2 protein, from Yeast, contains 609 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Sterol O-acyltransferase that catalyzes the formation of stery esters

Belongs to the membrane-bound acyltransferase family, Sterol o-acyltransferase subfamily


This is Cysteine-rich venom protein kaouthin-1 protein, from Monocled cobra, contains 239 amino acids, is soluble, locates in Extracellular.

Inhibits calcium-activated potassium channels (KCa), voltage-gated potassium channel (Kv), and the calcium release channel/ryanodine receptor (RyR)


This is Nigrocin-2GRc protein, from Yunnanfu frog, contains 67 amino acids, is soluble, locates in Extracellular.

Antimicrobial peptide active at least against the Gram-positive bacterium S,aureus but with otherwise unclear activity spectrum (PubMed:16487561, PubMed:16621155), Lacks hemolytic activity against rabbit or human erythrocytes (PubMed:16487561, PubMed:16621155)

Belongs to the frog skin active peptide (FSAP) family, Brevinin subfamily


This is Nigrocin-2GRa protein, from Yunnanfu frog, contains 66 amino acids, is soluble, locates in Extracellular.


This is Bombesin protein, from Palawan frog, contains 67 amino acids, is soluble, locates in Extracellular.

Stimulates smooth muscle contraction in isolated rat stomach strip

Belongs to the bombesin/neuromedin-B/ranatensin family


This is Spiderine-2a protein, from Lynx spider, contains 171 amino acids, is soluble, locates in Extracellular.

Has antimicrobial, insecticidal, cytolytic and cytotoxic activity

Belongs to the spiderine family, Cationic/spiderine subfamily


This is Thymine dioxygenase JBP1 protein, from Trypanosoma brucei brucei, contains 839 amino acids, locates in Nucleus.

Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU), DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation, Also specifically binds to base J-containing DNA (J-DNA), Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis, Thymine dioxygenase activity and J-DNA-binding are independent functions

Belongs to the TET family, JBP1 subfamily


This is Bombesin protein, from Sichuan frog, contains 67 amino acids, is soluble, locates in Extracellular.


This is C-8 sterol isomerase erg2 protein, from Fission yeast, contains 219 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

C-8 sterol isomerase; part of the third module of ergosterol biosynthesis pathway that includes by the late steps of the pathway (PubMed:18310029), Erg2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol (By similarity), The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane, Firstly, the squalene synthase erg9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids, Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase erg1 and the lanosterol synthase erg7, The lanosterol 14-alpha-demethylase erg11/cyp1 catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, In the next steps, a complex process involving various demethylation, reduction and desaturation reactions catalyzed by the C-14 reductase erg24 and the C-4 demethylation complex erg25-erg26-erg27 leads to the production of zymosterol, Erg28 likely functions in the C-4 demethylation complex reaction by tethering erg26 and Erg27 to the endoplasmic reticulum or to facilitate interaction between these proteins, Then, the sterol 24-C-methyltransferase erg6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol, The C-8 sterol isomerase erg2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol, The sterol-C5-desaturases erg31 and erg32 then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol, The C-22 sterol desaturase erg5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain, Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase erg4 to produce ergosterol (PubMed:18310029) (Probable), In the genus Schizosaccharomyces, a second route exists between lanosterol and fecosterol, via the methylation of lanosterol to eburicol by erg6, followed by C14-demethylation by erg11/cyp1 and C4-demethylation by the demethylation complex erg25-erg26-erg27 (PubMed:8586261) (Probable)


This is Response regulator mcs4 protein, from Fission yeast, contains 522 amino acids, is soluble, locates in Cytoplasm.

Response regulator that coordinately controls the stress activated wak1-wis1-sty1 MAP kinase pathway and fission yeast cell cycle


This is Protein CutA, chloroplastic protein, from Mouse-ear cress, contains 182 amino acids, is soluble, locates in Plastid.

Involved in metal homeostasis, Specifically binds Cu(2+), The truncated isoform has less specificity in metal binding


This is Isocitrate dehydrogenase [NAD] regulatory subunit 2, mitochondrial protein, from Mouse-ear cress, contains 367 amino acids, locates in Mitochondrion.

Performs an essential role in the oxidative function of the citric acid cycle

Belongs to the isocitrate and isopropylmalate dehydrogenases family


This is Probable LRR receptor-like serine/threonine-protein kinase RKF3 protein, from Mouse-ear cress, contains 617 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Cell growth regulator with EF hand domain protein 1 protein, from Rat, contains 281 amino acids, is soluble, locates in Extracellular.

Mediates cell-cell adhesion in a calcium-dependent manner, Able to inhibit growth in several cell lines


This is Complement component C8 beta chain protein, from Rabbit, contains 590 amino acids, is soluble, locates in Extracellular.

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells

Belongs to the complement C6/C7/C8/C9 family


This is Kievitone hydratase protein, from Nectria haematococca, contains 350 amino acids, is soluble, locates in Extracellular.

Converts fungitoxic kievitone to the less toxic kievitone hydrate, and thereby protects the pathogenic fungus against this phytoalexin


This is RNA polymerase II C-terminal domain phosphatase-like 4 protein, from Mouse-ear cress, contains 440 amino acids, locates in Nucleus.

Processively dephosphorylates 'Ser-2' and/or 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1), This promotes the activity of RNA polymerase II (By similarity), Required for normal plant growth


This is Alpha-amylase 1 protein, from Yeast, contains 624 amino acids, is soluble, locates in Extracellular.


This is Small ribosomal subunit protein mS29 protein, from Baker's yeast, contains 450 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane, mS29 binds GTP and is probably an active GTPase, GTP hydrolysis may be linked to subunit association (PubMed:25609543, PubMed:28154081), mS29 also has an extraribosomal function, being required for maintenance of mitochondrial DNA (PubMed:11017876)

Belongs to the mitochondrion-specific ribosomal protein mS29 family


This is Large ribosomal subunit protein mL50 protein, from Baker's yeast, contains 264 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the mitochondrion-specific ribosomal protein mL50 family


This is tRNA (uracil-O(2)-)-methyltransferase protein, from Baker's yeast, contains 567 amino acids, is soluble, locates in Cytoplasm.

tRNA (uracil-O(2)-)-methyltransferase, which catalyzes the formation of O(2)-methyluracil at position 44 (Um44) in tRNA(Ser)


This is Protein MUK1 protein, from Baker's yeast, contains 612 amino acids, is soluble, locates in Cytoplasm.


This is Peroxisomal membrane protein PEX29 protein, from Baker's yeast, contains 554 amino acids, is membrane-bound, locates in Peroxisome.

Involved in the regulation of peroxisome number, size and distribution

Belongs to the PEX28-32 family, PEX29 subfamily


This is Beta-1,4-mannosyltransferase bre-3 protein, from Caenorhabditis elegans, contains 455 amino acids, is soluble, locates in Cytoplasm.

Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis (PubMed:12944392, PubMed:10924467), Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-4 and bre-5 (PubMed:12944392, PubMed:10924467), Involved in resistance to the nematotoxic C,cinerea galectin Cgl2 (PubMed:20062796), Has a role in determining brood size (PubMed:12944392, PubMed:10924467)

Belongs to the glycosyltransferase 2 family


This is U1 small nuclear ribonucleoprotein component PRP42 protein, from Baker's yeast, contains 544 amino acids, locates in Nucleus.

Essential component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA, Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway, U1 snRNP is cotranscriptionally recruited to intron-containing genes, Required for U1 snRNP biogenesis


This is Golgi apparatus membrane protein TVP15 protein, from Baker's yeast, contains 143 amino acids, is membrane-bound, locates in Golgi apparatus.

Golgi membrane protein involved in vesicular trafficking


This is Meiosis-specific protein HED1 protein, from Baker's yeast, contains 162 amino acids, locates in Nucleus.

Involved in regulation of meiotic recombination and repair of DNA damage, Inhibits RAD51-mediated recombination when the meiotic recombination machinery is impaired


This is ISWI one complex protein 4 protein, from Baker's yeast, contains 475 amino acids, locates in Nucleus.

Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA, The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing


This is RNA polymerase I-specific transcription initiation factor RRN11 protein, from Baker's yeast, contains 507 amino acids, locates in Nucleus.

Acts as component of the core factor (CF) complex which is essential for the initiation of rDNA transcription by RNA polymerase I, After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a preinitiation complex


This is Signal peptidase complex subunit 2 protein, from Baker's yeast, contains 178 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:8910564, PubMed:10921929), Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (PubMed:8910564, PubMed:10921929)


This is Ribonuclease H2 subunit B protein, from Baker's yeast, contains 350 amino acids, locates in Nucleus.

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids, Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication, Mediates the excision of single ribonucleotides from DNA:RNA duplexes

Belongs to the RNase H2 subunit B family, Highly divergent


This is Phosphatase DCR2 protein, from Baker's yeast, contains 578 amino acids, is soluble, locates in Cytoplasm.

Required for cell cycle progression, Has a role in the completion of START


This is Glutaredoxin-8 protein, from Baker's yeast, contains 109 amino acids, is soluble, locates in Cytoplasm.

Glutathione-dependent oxidoreductase with lower activity compared to the other members of the glutaredoxin family, The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase


This is Abscisic acid 8'-hydroxylase 1 protein, from Rice, contains 471 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the oxidative degradation of abscisic acid


This is 21S rRNA pseudouridine(2819) synthase protein, from Baker's yeast, contains 254 amino acids, locates in Mitochondrion.

Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA, May modulate the efficiency or the fidelity of the mitochondrial translation machinery

Belongs to the pseudouridine synthase RluA family


This is Probable vacuolar amino acid transporter YPQ2 protein, from Baker's yeast, contains 317 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole


This is Decapping and exoribonuclease protein 1 protein, from Baker's yeast, contains 442 amino acids, is soluble, locates in Cytoplasm.

Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity), The NAD-cap is present at the 5'-end of some RNAs and snoRNAs, In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity), Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (PubMed:22961381), Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (PubMed:22961381), Also has 5'-3' exonuclease activity (PubMed:22961381)


This is SWR1-complex protein 7 protein, from Baker's yeast, contains 132 amino acids, locates in Nucleus.

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling


This is Cytoplasmic 60S subunit biogenesis factor REH1 protein, from Baker's yeast, contains 432 amino acids, has 3 C2H2-type Zinc finger, is soluble, locates in Cytoplasm.

Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit, May act redundantly with REI1 to directly promote a stabilizing structural rearrangement in cytoplasmic 60S subunit maturation independent on the REI1-specific ARX1 recycling


This is External NADH-ubiquinone oxidoreductase 2, mitochondrial protein, from Baker's yeast, contains 545 amino acids, is soluble, locates in Mitochondrion.

External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol, With NDE1, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions, Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxidation

Belongs to the NADH dehydrogenase family


This is Ribosome biogenesis ATPase RIX7 protein, from Baker's yeast, contains 837 amino acids, locates in Nucleus.

Involved in ribosome biogenesis, Seems to be required for restructuring nucleoplasmic 60S pre-ribosomal particles to make them competent for nuclear export


This is 60S ribosome subunit biogenesis protein NOP8 protein, from Baker's yeast, contains 484 amino acids, locates in Nucleus.

Required for 60S ribosomal subunit synthesis, May be involved in assembly reactions occurring within late pre-ribosomal particles


This is Thiosulfate sulfurtransferase RDL2, mitochondrial protein, from Baker's yeast, contains 149 amino acids, locates in Mitochondrion.

Thiosulfate sulfurtransferase which catalyzes the transfer of sulfane sulfur from thiosulfate to cyanide


This is RNA-binding protein MRN1 protein, from Baker's yeast, contains 612 amino acids, is soluble, locates in Cytoplasm.

RNA-binding protein that binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES), Probably involved in translational regulation


This is Protein lin-56 protein, from Caenorhabditis elegans, contains 322 amino acids, locates in Nucleus.

Required for translation, stability and/or localization of lin-15a


This is GPI mannosyltransferase 2 protein, from Fission yeast, contains 464 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis, Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity)


This is Tuberous sclerosis 1 protein homolog protein, from Fission yeast, contains 899 amino acids, is soluble, locates in Cytoplasm.

Together with tsc2, required for uptake of various amino acids from the environment and for proper conjugation, Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation, May act as a GTPase-activating protein (GAP) for the small GTPase rhb1


This is RNA-binding post-transcriptional regulator cip2 protein, from Fission yeast, contains 576 amino acids, is soluble, locates in Cytoplasm.

Regulates global gene expression after oxidative stress, Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress


This is Pentatricopeptide repeat-containing protein At5g04810, chloroplastic protein, from Mouse-ear cress, contains 952 amino acids, locates in Plastid.

May play a role in the plastid ribosome biogenesis


This is Outer envelope pore protein 16-2, chloroplastic protein, from Mouse-ear cress, contains 178 amino acids, is membrane-bound, locates in Plastid.

Voltage-dependent high-conductance channel with a slight cation-selectivity; selective for amino acids but excludes triosephosphates or uncharged sugars (By similarity), Non-essential amino acid-selective channel protein and translocation pore for NADPH:protochlorophyllide oxidoreductase A (PORA) and possibly PORB

Belongs to the Tim17/Tim22/Tim23 family, Plastid outer envelope porin OEP16 (TC 1,B,30) subfamily


This is AUGMIN subunit 7 protein, from Mouse-ear cress, contains 329 amino acids, is soluble, locates in Cytoplasm.

Contributes to the assembly of the acentrosomal spindle and phragmoplast microtubule arrays as part of the augmin complex, Regulates the association of gamma-tubulin with the spindle and phragmoplast microtubules


This is Probable sterol O-acyltransferase 1 protein, from Fission yeast, contains 537 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Sterol O-acyltransferase that catalyzes the formation of stery esters


This is Kinetochore protein spc25 protein, from Fission yeast, contains 238 amino acids, locates in Nucleus.

Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle, Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity


This is Phosphoglycerate mutase 2 protein, from Baker's yeast, contains 311 amino acids, is soluble, locates in Cytoplasm.

Belongs to the phosphoglycerate mutase family, BPG-dependent PGAM subfamily


This is Probable vacuolar amino acid transporter YPQ1 protein, from Baker's yeast, contains 308 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

May function as an amino acid transporter mediating the export of cationic amino acids from the vacuole


This is rRNA-processing protein FCF2 protein, from Baker's yeast, contains 217 amino acids, locates in Nucleus.

Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly, Required for the early cleavage steps of 35S rRNA at the A(0), A(1), and A(2) sites


This is ISWI one complex protein 2 protein, from Baker's yeast, contains 812 amino acids, locates in Nucleus.

Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA, The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing


This is Cleavage factor two protein 2 protein, from Baker's yeast, contains 859 amino acids, locates in Nucleus.

RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB, May be involved in poly(A)-site recognition, May be involved in the association of the CPF, CPFIA and RNA polymerase II complexes


This is Probable phospholipase YOR022C, mitochondrial protein, from Baker's yeast, contains 715 amino acids, locates in Mitochondrion.

Probable phospholipase that hydrolyzes phosphatidic acid


This is Rhomboid protein 2 protein, from Baker's yeast, contains 262 amino acids, is membrane-bound, locates in Golgi apparatus.


This is Ammonia transport outward protein 3 protein, from Baker's yeast, contains 275 amino acids, is membrane-bound, locates in Cell membrane.

Transporter protein required for ammonia export, Induced in rho(0) cells, probably to eliminate the excess ammonia that arises because of a potential defect in ammonia assimilation in those cells

Belongs to the acetate uptake transporter (AceTr) (TC 2,A,96) family


This is Protein STB3 protein, from Baker's yeast, contains 513 amino acids, is soluble, locates in Cytoplasm.


This is Large ribosomal subunit protein uL13m protein, from Baker's yeast, contains 163 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the universal ribosomal protein uL13 family


This is Probable splicing factor, arginine/serine-rich 6 protein, from Caenorhabditis elegans, contains 179 amino acids, locates in Nucleus.

Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaprodites, Required for the development of somatic gonad structures and for progression from larval stage to adulthood

Belongs to the splicing factor SR family


This is Mu-conotoxin Lt5d protein, from Lettered cone, contains 62 amino acids, is soluble, locates in Extracellular.

Mu-conotoxins block voltage-gated sodium channels (Nav), This toxin inhibits tetrodotoxin(TTX)-sensitive sodium channels, but does not affect TTX-resistant sodium channels, Reduces the amplitude of currents without changing the activation and inactivation kinetics of currents


This is LIM domain-containing protein PLIM2b protein, from Mouse-ear cress, contains 205 amino acids, is soluble, locates in Cytoplasm.

Binds to actin filaments and promotes cross-linking into thick bundles, Has an actin-stabilizing activity, The actin regulatory activities are inhibited by pH > 6,8 but are [Ca(2+)] independent


This is Dermaseptin-H4 protein, from Orange-legged monkey tree frog, contains 73 amino acids, is soluble, locates in Extracellular.

Has antibacterial activity against the Gram-negative bacteria E,coli ATCC 11775 (MIC=0,8 uM), and the Gram-positive bacteria S,aureus ATCC 12600 (MIC=0,4 uM) and M,luteus ATCC 49732 (MIC=0,8 uM), Does not inhibit the growth of the fungus C,albicans, Probably acts by disturbing membrane functions with its amphipathic structure

Belongs to the frog skin active peptide (FSAP) family, Dermaseptin subfamily


This is Amino-acid acetyltransferase, mitochondrial protein, from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), contains 712 amino acids, locates in Mitochondrion.

N-acetylglutamate synthase involved in arginine biosynthesis


This is Serine protease 53 protein, from Human, contains 553 amino acids, is soluble, locates in Extracellular.

In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator


This is Zinc finger protein STAR3 protein, from Rice, contains 465 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 3; atypical Zinc finger, has 1 C2H2-type 4; atypical Zinc finger, locates in Nucleus.

C2H2-type 2; atypical

C2H2-type 3; atypical

C2H2-type 4; atypical

Transcriptional activator that regulates the expression of genes involved in aluminum (Al) tolerance, Binds to the promoter of STAR1 and regulates transcript expression of STAR1 STAR2 and ART1 required for Al tolerance


This is Fez family zinc finger protein 2 protein, from Bovine, contains 458 amino acids, has 6 C2H2-type Zinc finger, locates in Nucleus.

Transcription repressor, Binds to 5'GCAG-3' core sequence, Required for the specification of corticospinal motor neurons and other subcerebral projection neurons, May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation, Controls the development of dendritic arborization and spines of large layer V pyramidal neurons (By similarity), May be responsible for mastitis resistance and innate immunity

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Histone chaperone ASF1 protein, from Chicken, contains 204 amino acids, locates in Nucleus.

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly, Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly, May also cooperate with HIRA to promote replication-independent chromatin assembly


This is rRNA-processing protein EFG1 protein, from Baker's yeast, contains 233 amino acids, locates in Nucleus.

Involved in rRNA processing, Required growth at elevated temperatures, resistance to hydroxyurea and for cell cycle progression


This is Succinate dehydrogenase assembly factor 1, mitochondrial protein, from Baker's yeast, contains 79 amino acids, is soluble, locates in Mitochondrion.

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol, Promotes maturation of the iron-sulfur protein subunit SDH2 of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants, Acts together with SDHAF3 (SDH7)

Belongs to the complex I LYR family, SDHAF1 subfamily


This is MAP7 domain-containing protein 1 protein, from Human, contains 841 amino acids, is soluble, locates in Cytoplasm.


This is ATPase family AAA domain-containing protein 3 protein, from Rat, contains 591 amino acids, is membrane-bound, locates in Mitochondrion.

Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level, May play an important role in mitochondrial protein synthesis, May also participate in mitochondrial DNA replication, May bind to mitochondrial DNA D-loops and contribute to nucleoid stability, Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis, Involved in mitochondrial-mediated antiviral innate immunity


This is Transmembrane protein 120B protein, from Mouse, contains 339 amino acids, is membrane-bound, locates in Nucleus.

Necessary for efficient adipogenesis (PubMed:26024229), Does not show ion channel activity (PubMed:32084332)


This is Prostaglandin E synthase 3 protein, from Bovine, contains 160 amino acids, is soluble, locates in Cytoplasm.

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2), Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes, Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway


This is ATP synthase membrane subunit K, mitochondrial protein, from Bovine, contains 58 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain, F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk, During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation, ATP5MK is a minor subunit of the mitochondrial membrane ATP synthase required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria


This is Polygalacturonase-1 non-catalytic subunit beta protein, from Tomato, contains 630 amino acids, is soluble, locates in Extracellular.

Non-catalytic subunit of the polygalacturonase isozyme 1 (PG1), Necessary and sufficient to convert the polygalacturonase from its monomeric form PG2 to its heterodimeric form PG1, Seems to limit the depolymerization and solubilization of cell wall polyuronides mediated by PG2 during ripening, probably by recruiting PG2 to form PG1


This is Lycopene beta cyclase, chloroplastic/chromoplastic protein, from Daffodil, contains 503 amino acids, is membrane-bound, locates in Plastid.

Catalyzes the double cyclization reaction which converts lycopene to beta-carotene and neurosporene to beta-zeacarotene


This is Thiamine thiazole synthase 1, chloroplastic protein, from Maize, contains 354 amino acids, locates in Plastid.

Involved in biosynthesis of the thiamine precursor thiazole, Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate, The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate, The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme, May have additional roles in adaptation to various stress conditions and in DNA damage tolerance


This is NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial protein, from Mouse-ear cress, contains 222 amino acids, locates in Mitochondrion.

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis, Complex I functions in the transfer of electrons from NADH to the respiratory chain, The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity), May donate electrons to ubiquinone

Belongs to the complex I 23 kDa subunit family


This is Elastase inhibitor AFUEI protein, from Neosartorya fumigata, contains 87 amino acids, is soluble, locates in Extracellular.

Elastase inhibitor, Non-competitive inhibitor of A,fumigatus elastase with a Ki of 1,6 nM, Inhibits the fibrinogenase and collagenase activities of A,fumigatus elastase, Inhibitor of A,flavus elastase and human leukocyte elastase, and weakly inhibits porcine pancreatic elastase, Does not inhibit elastase from P,aeruginosa or C,atrox venom


This is LIM domain-containing protein PLIM2c protein, from Mouse-ear cress, contains 213 amino acids, is soluble, locates in Cytoplasm.

Binds to actin filaments and promotes cross-linking into thick bundles, Has an actin-stabilizing activity, Associates predominantly with long and dynamic actin bundles in the shank of growing pollen tubes, The actin regulatory activities are inhibited by pH > 6,8 and/or high [Ca(2+)]


This is P2X receptor D protein, from Social amoeba, contains 407 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

P2X receptors are ligand-gated ion channels that play a role in intracellular calcium signaling, ATP does not evoke inward currents in p2xD, Not essential for osmoregulation


This is P2X receptor C protein, from Social amoeba, contains 368 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

P2X receptors are ligand-gated ion channels that play a role in intracellular calcium signaling, ATP does not evoke inward currents in p2xC, Not essential for osmoregulation


This is Copper transport protein CTR1 protein, from Yeast, contains 251 amino acids, is membrane-bound, locates in Cell membrane.

Required for high affinity copper (probably reduced Cu I) transport into the cell


This is MFS antiporter QDR2 protein, from Yeast, contains 504 amino acids, is membrane-bound, locates in Cell membrane.

MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence, No substrate for transport has been identified yet, but plays an important role in the growth in the host

Belongs to the major facilitator superfamily, CAR1 family


This is MFS antiporter QDR1 protein, from Yeast, contains 509 amino acids, is membrane-bound, locates in Cell membrane.


This is Actin-regulating kinase PRK1 protein, from Yeast, contains 690 amino acids, is soluble, locates in Cytoplasm.

Protein kinase involved in regulation of actin cytoskeleton organization and endocytosis, Phosphorylates the endocytic protein SLA1, The CDC28-CLN3 complex phosphorylation of SLA1 enhances its further phosphorylation by PRK1, weakening SLA1 association with PAN1, an activator of the actin-nucleating ARP2/3 complex, Plays a role in cell wall regulation and required for oxidative stress survival

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Secreted protein RBT4 protein, from Yeast, contains 358 amino acids, is soluble, locates in Extracellular.

Secreted protein that acts as a virulence factor during infections such as in posttraumatic corneal infections, Acts as an important antigen in patients with systemic candidiasis and plays a role in the protection against phagocyte attack


This is S-type anion channel SLAH1 protein, from Mouse-ear cress, contains 385 amino acids, is membrane-bound, locates in Cell membrane.

Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis

Belongs to the SLAC1 S-type anion channel family


This is Intraflagellar transport protein 57 homolog protein, from Bovine, contains 429 amino acids, is soluble, locates in Cytoplasm.

Required for the formation of cilia, Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway, Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis, Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear (By similarity)


This is E3 ubiquitin-protein ligase CHFR protein, from African clawed frog, contains 625 amino acids, has 1 RING-type Zinc finger, has 1 PBZ-type Zinc finger, locates in Nucleus.

RING-type

PBZ-type

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons, Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus, Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome, May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer, Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress


This is Transcription factor TIP2 protein, from Rice, contains 379 amino acids, locates in Nucleus.

Transcription factor that binds to the E-box-containing promoter regions of the transcription factors TDR and EAT1, activating their expression, May have a role in specifying the cell pattern of the inner anther walls and functioning in meiosis progression, Required for male reproduction (PubMed:24755456), Acts downstream of UDT1 and GAMYB, but upstream of TDR1 and EAT1 in pollen development (PubMed:24894043)