This is Protein indeterminate-domain 14 protein, from Mouse-ear cress, contains 419 amino acids, has 3 C2H2-type Zinc finger, has 1 CCHC-type 2; atypical Zinc finger, locates in Nucleus.

CCHC-type 2; atypical

Transcription factor regulating starch metabolism by binding directly to the promoter of QQS (PubMed:21556057), The IDD14beta isoform attenuates the transcription factor activity by competitively forming heterodimers with reduced DNA-binding capacity(PubMed:21556057), Regulates lateral organ morphogenesis and gravitropic responses (PubMed:24039602), Has a redundant role with IDD16 in directing leaf and floral organ morphogenesis (PubMed:24039602), Involved in the establishment of auxin gradients through the regulation of auxin biosynthesis and transport (PubMed:24039602)


This is NAD(P)H-quinone oxidoreductase subunit L, chloroplastic protein, from Mouse-ear cress, contains 191 amino acids, is membrane-bound, locates in Plastid.

NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain, The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone, Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient

Belongs to the NDH complex subunit L family


This is U11/U12 small nuclear ribonucleoprotein 31 kDa protein protein, from Mouse-ear cress, contains 261 amino acids, has 1 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type

RNA chaperone required for proper U12 intron splicing and for normal growth and development of plants, Mainly responsible for meristem activity, Plays a role in regulating cell division


This is Proline-rich receptor-like protein kinase PERK13 protein, from Mouse-ear cress, contains 710 amino acids, is membrane-bound, locates in Cell membrane.

Regulates negatively root hairs elongation

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Neudesin protein, from Mouse, contains 171 amino acids, is soluble, locates in Extracellular.

Acts as a neurotrophic factor in postnatal mature neurons, enhancing neuronal survival (PubMed:15605373, PubMed:31536960), Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocytes (PubMed:16547973), Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (PubMed:15605373, PubMed:16547973), Neurotrophic activity is enhanced by binding to heme (PubMed:18056703), Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (PubMed:23576617)

Belongs to the cytochrome b5 family, MAPR subfamily


This is Sclerostin domain-containing protein 1 protein, from Mouse, contains 206 amino acids, is soluble, locates in Extracellular.

May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction, Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity), Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner


This is Translocator protein 2 protein, from Mouse, contains 162 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Cholesterol-binding protein involved in the redistribution of cholesterol from lipid droplets to the endoplasmic reticulum (PubMed:19729679, PubMed:32358067), Required to meet cholesterol demands during erythropoietic differentiation (PubMed:19729679, PubMed:32358067), May play a role in transport processes at the plasma membrane of erythrocytes, including regulating VDAC-mediated ATP export, and import of the heme precursors protoporphyrin IX and 5-aminolevulinic acid (By similarity)


This is Developmental pluripotency-associated protein 2 protein, from Mouse, contains 301 amino acids, locates in Nucleus.

Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes


This is Transmembrane protein 178A protein, from Mouse, contains 297 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1 (PubMed:26644563)


This is Pre-mRNA-splicing factor SYF2 protein, from Mouse, contains 242 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing as component of the spliceosome


This is Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 protein, from Mouse, contains 614 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors, Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity), Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development


This is Interleukin-36 beta protein, from Mouse, contains 183 amino acids, is soluble, locates in Extracellular.

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response, Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP, Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes, Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity), Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation, Induces the production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs, Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II, Induces the production of IFN-gamma, IL-4 and IL-17 by T-helper 1 (Th1) cells, cultured CD4(+) T-cells and splenocytes


This is Interleukin-23 subunit alpha protein, from Mouse, contains 196 amino acids, is soluble, locates in Extracellular.

Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383, PubMed:11390512, PubMed:16670770), Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (By similarity), This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A (PubMed:19900478), In turn, participates in the early and effective intracellular bacterial clearance (PubMed:16157683), Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:16648837)


This is Zinc finger protein 384 protein, from Rat, contains 579 amino acids, has 8 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor that binds the consensus DNA sequence [GC]AAAAA, Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Lck-interacting transmembrane adapter 1 protein, from Mouse, contains 269 amino acids, is membrane-bound, locates in Cell membrane.

Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells, In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation, Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules


This is Tripartite motif-containing protein 54 protein, from Mouse, contains 366 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

B box-type

May bind and stabilize microtubules during myotubes formation


This is Fez family zinc finger protein 2 protein, from Mouse, contains 455 amino acids, has 6 C2H2-type Zinc finger, locates in Nucleus.

Transcription repressor, Required for the specification of corticospinal motor neurons and other subcerebral projection neurons, May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation, Controls the development of dendritic arborization and spines of large layer V pyramidal neurons, Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation


This is Transcription factor HFR1 protein, from Mouse-ear cress, contains 292 amino acids, locates in Nucleus.

Atypical bHLH transcription factor that regulates photomorphogenesis through modulation of phytochrome (e,g, PHYA) and cryptochrome signalings (Ref,4, PubMed:11090209, PubMed:10995393, PubMed:19482971), Suppresses the transcriptional regulation activity of PIF4 by forming non-DNA-binding heterodimer


This is Probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2 protein, from Mouse-ear cress, contains 480 amino acids, is soluble, locates in Cytoplasm.

Probable regulatory subunit of type 2A protein phosphatase involved in the control of the dynamic organization of the cortical cytoskeleton, Plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry, Required for the reorganization of cortical arrays in response to light


This is Chromatin remodeling protein SHL protein, from Mouse-ear cress, contains 228 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Chromatin remodeling factor that binds to methylated histone (e,g, H3K4me2/3) to prevent their acetylation (e,g, H3K9K14Ac), likely by recruiting histone deacetylase (HDAC) complexes, and thus regulate the transcription of target genes (PubMed:25281686), Required during development and for fertility, probably by modulating developmental gene expression (PubMed:11129039, PubMed:15082927, PubMed:25281686), Promotes development speed, but at fitness cost (PubMed:11129039), Involved in the chromatin-mediated repression of floral initiation and controls genes regulating flowering, Negatively regulates the expression of the floral integrator SOC1, by preventing high levels of H3 acetylation, thus maintaining an inactive chromatin conformation (PubMed:25281686)


This is Seipin-1 protein, from Mouse-ear cress, contains 368 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size, Facilitates the formation of large-sized LDs and modulates triacylglycerol accumulation, Induces probably a reorganization of the endoplasmic reticulum into LD-forming domains


This is Zinc finger protein NUTCRACKER protein, from Mouse-ear cress, contains 466 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger, locates in Nucleus.

C2H2-type 2; degenerate

CCHC-type 2; atypical

Transcription activator that binds to the DNA sequence 5'-CTTTTGTCC-3' (PubMed:21265895, PubMed:25929516), Regulates photoperiodic flowering by modulating sugar transport and metabolism (PubMed:21265895, PubMed:25929516), Regulates SUS1 and SUS4 (PubMed:21265895), Transcription factor that regulates tissue boundaries and asymmetric cell division (PubMed:25829440), Contributes to the sequestration of 'SHORT-ROOT' to the nucleus (PubMed:25829440)


This is Nuclear pore complex protein NUP88 protein, from Mouse-ear cress, contains 810 amino acids, locates in Nucleus.

Involved in the regulation of exportin-mediated nuclear protein export, Required for resistance mediated by multiple R proteins and for the appropriate nuclear accumulation of SNC1 and of the downstream defense signaling components EDS1 and NPR1, Not involved in salt tolerance, ethylene and auxin responses, but required for systemic acquired resistance


This is Sucrose transport protein SUC9 protein, from Mouse-ear cress, contains 491 amino acids, is membrane-bound, locates in Cell membrane.

High-affinity sucrose transporter, Responsible for the transport of sucrose into the cell, with the concomitant uptake of protons (symport system), Can also transport a wide range of glucosides, such as helicin, salicin, arbutin, maltose, fraxin, esculin, uranose, alpha-methylglucoside, alpha-phenylglucoside and beta-phenylglucoside, Plays a role in flowering time transition delay

Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2,A,2,4) family


This is WPP domain-interacting protein 2 protein, from Mouse-ear cress, contains 509 amino acids, is membrane-bound, locates in Nucleus.

Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips (PubMed:17600715), As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PubMed:25759303)


This is AT-hook motif nuclear-localized protein 4 protein, from Mouse-ear cress, contains 419 amino acids, locates in Nucleus.

Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs) (By similarity), Acts redundantly with AHL3 to regulate the formation of tissue boundary between the xylem and procambium in the root meristem, Cell-to-cell movement of AHL4 from the procambium to the xylem is critical for its function in root vascular patterning (PubMed:23335615)


This is SWR1 complex subunit 6 protein, from Mouse-ear cress, contains 171 amino acids, has 1 HIT-type Zinc finger, locates in Nucleus.

HIT-type

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A,F/Z leading to transcriptional regulation of selected genes (e,g, FLC) by chromatin remodeling, Coodinates SWR1-C, FRI-C (FLC transcription activator complex), histone methyltransferase and general transcription factors, Represses flowering by positively regulating FLC and MAF4, Binds to the promoter region of FLC chromatin


This is Mitogen-activated protein kinase kinase 6 protein, from Mouse-ear cress, contains 356 amino acids, is soluble, locates in Cytoplasm.

The ANPs-MKK6-MPK4 module is involved in the regulation of plant cytokinesis during meiosis and mitosis, MKK6-MPK13 module positively regulates lateral root formation, Phosphorylates and activates MPK4, Activates MPK5 and MPK13 in vitro

Belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily


This is Putative E3 ubiquitin-protein ligase RING1a protein, from Mouse-ear cress, contains 522 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

As part of the PRC1-like complex, repress class I KNOX gene expression, PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility


This is S-type anion channel SLAH3 protein, from Mouse-ear cress, contains 635 amino acids, is membrane-bound, locates in Cell membrane.

Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis (PubMed:18305482), Binds to the highly selective inward-rectifying potassium channel KAT1 and inhibits its activity, Functions as an essential negative regulator of inward potassium channels in guard cells, Essential for the efficient stomatal closure and opening in guard cells (PubMed:27002025)

Belongs to the SLAC1 S-type anion channel family


This is Calcium sensing receptor, chloroplastic protein, from Mouse-ear cress, contains 387 amino acids, is membrane-bound, locates in Plastid.

Modulates cytoplasmic Ca(2+) concentration and is crucial for proper stomatal regulation in response to elevated levels of external Ca(2+), May function by regulating concentrations of inositol 1,4,5-trisphosphate (IP3), which in turn triggers release of Ca(2+) from internal stores, May play a role in de-etiolation


This is Starch synthase 1, chloroplastic/amyloplastic protein, from Mouse-ear cress, contains 652 amino acids, locates in Plastid.

Involved in the synthesis of short glycan chains within amylopectin in leaves, Is required to generate chains up to about a degree of polymerization of 10 (DP10)

Belongs to the glycosyltransferase 1 family, Bacterial/plant glycogen synthase subfamily


This is Protein NIM1-INTERACTING 3 protein, from Mouse-ear cress, contains 112 amino acids, locates in Nucleus.


This is Protein TONNEAU 1b protein, from Mouse-ear cress, contains 257 amino acids, is soluble, locates in Cytoplasm.

Involved in the control of the dynamic organization of the cortical cytoskeleton, May play a role in the organization of microtubule arrays at the centrosome through interaction with centrin 1 (CEN1)


This is Protein TONNEAU 1a protein, from Mouse-ear cress, contains 260 amino acids, is soluble, locates in Cytoplasm.


This is MADS-box protein SVP protein, from Mouse-ear cress, contains 240 amino acids, locates in Nucleus.

Transcription repressor that inhibit floral transition in the autonomous flowering pathway, independent of photoperiod and temperature, Acts in a dosage-dependent manner, Together with AGL24 and AP1, controls the identity of the floral meristem and regulates expression of class B, C and E genes, Promotes EFM expression to suppress flowering (PubMed:25132385)


This is Sucrose synthase 6 protein, from Mouse-ear cress, contains 942 amino acids, is soluble, locates in Extracellular.

Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways, Functions in callose synthesis at the site of phloem sieve elements

Belongs to the glycosyltransferase 1 family, Plant sucrose synthase subfamily


This is Trihelix transcription factor GT-1 protein, from Mouse-ear cress, contains 406 amino acids, locates in Nucleus.

Probable transcription factor that binds specifically to the core DNA sequence 5'-GGTTAA-3', May act as a molecular switch in response to light signals


This is Protein SHI RELATED SEQUENCE 7 protein, from Mouse-ear cress, contains 345 amino acids, locates in Nucleus.

Transcription activator that binds DNA on 5'-ACTCTAC-3' and promotes auxin homeostasis-regulating gene expression (e,g, YUC genes), as well as genes affecting stamen development, cell expansion and timing of flowering, Synergistically with other SHI-related proteins, regulates gynoecium, stamen and leaf development in a dose-dependent manner, controlling apical-basal patterning, Promotes style and stigma formation, and influences vascular development during gynoecium development, May also have a role in the formation and/or maintenance of the shoot apical meristem (SAM), Regulates anther dehiscence and floral development


This is HMG-Y-related protein A protein, from Maize, contains 193 amino acids, locates in Nucleus.

Binds A/T-rich DNA (e,g, present in the storage gamma-zein gene promoter) with a highly dynamic distribution into the nucleus (PubMed:19781672, PubMed:10864924), Probably involved in endosperm development, during cells shift from a mitotic cycle to endoreduplication leading to massive synthesis of storage proteins (zeins) and starch (PubMed:10864924)


This is Protein AUXIN RESPONSE 4 protein, from Mouse-ear cress, contains 473 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for the auxin influx facilitator AUX1 polar trafficking and its asymmetric localization within the plasma membrane, Not involved in the PIN proteins localization


This is Beta-casein protein, from Horse, contains 241 amino acids, is soluble, locates in Extracellular.

Important role in determination of the surface properties of the casein micelles


This is Brain-specific serine protease 4 protein, from Human, contains 317 amino acids, is soluble, locates in Extracellular.

Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA


This is Protein rogdi homolog protein, from Human, contains 287 amino acids, locates in Nucleus.


This is Platelet-derived growth factor D protein, from Human, contains 370 amino acids, is soluble, locates in Extracellular.

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis, Potent mitogen for cells of mesenchymal origin, Plays an important role in wound healing, Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis, Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity)

Belongs to the PDGF/VEGF growth factor family


This is Fibroblast growth factor 23 protein, from Human, contains 251 amino acids, is soluble, locates in Extracellular.

Regulator of phosphate homeostasis (PubMed:11062477), Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (PubMed:11409890), Up-regulates EGR1 expression in the presence of KL (By similarity), Acts directly on the parathyroid to decrease PTH secretion (By similarity), Regulator of vitamin-D metabolism (PubMed:15040831), Negatively regulates osteoblast differentiation and matrix mineralization (PubMed:18282132)

Belongs to the heparin-binding growth factors family


This is Inhibitor of growth protein 2 protein, from Human, contains 280 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53, Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones, ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs)


This is Homeobox protein aristaless-like 4 protein, from Human, contains 411 amino acids, locates in Nucleus.

Transcription factor involved in skull and limb development, Plays an essential role in craniofacial development, skin and hair follicle development


This is Nucleotide exchange factor SIL1 protein, from Human, contains 461 amino acids, is soluble, locates in Endoplasmic reticulum.

Required for protein translocation and folding in the endoplasmic reticulum (ER), Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5


This is Olfactory receptor 51E2 protein, from Human, contains 320 amino acids, is membrane-bound, locates in Cell membrane.

Olfactory receptor (PubMed:29249973, PubMed:27226631), Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:29249973, PubMed:27226631, PubMed:19389702), The activity of this receptor is probably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973), Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631), Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973), Activated also by the short-chain fatty acids (SCFA) acetate and propionate, In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498), May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702), Activated by L-lactate in glomus cells (By similarity)

Belongs to the G-protein coupled receptor 1 family


This is Homeobox protein MIXL1 protein, from Human, contains 232 amino acids, locates in Nucleus.

Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation, Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages, Also involved in the morphogenesis of the heart and the gut during embryogenesis, Acts as a negative regulator of brachyury expression (By similarity)


This is Mitochondrial translation release factor in rescue protein, from Human, contains 166 amino acids, locates in Mitochondrion.

Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:33243891), As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes, Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891)

Belongs to the prokaryotic/mitochondrial release factor family


This is Lck-interacting transmembrane adapter 1 protein, from Human, contains 295 amino acids, is membrane-bound, locates in Cell membrane.

Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells, In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation, Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules


This is SPARC-related modular calcium-binding protein 1 protein, from Human, contains 434 amino acids, is soluble, locates in Extracellular.

Plays essential roles in both eye and limb development, Probable regulator of osteoblast differentiation


This is Receptor expression-enhancing protein 4 protein, from Human, contains 257 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis, Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes


This is Protein N-lysine methyltransferase METTL21D protein, from Human, contains 229 amino acids, is soluble, locates in Cytoplasm.

Protein N-lysine methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity

Belongs to the methyltransferase superfamily, METTL21 family


This is Multimerin-2 protein, from Human, contains 949 amino acids, is soluble, locates in Extracellular.

Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it down-regulates KDR activation by binding VEGFA


This is L-2-hydroxyglutarate dehydrogenase, mitochondrial protein, from Human, contains 463 amino acids, locates in Mitochondrion.


This is Homeobox protein NANOG protein, from Human, contains 305 amino acids, locates in Nucleus.

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal, Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages, Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes, Acts as a transcriptional activator or repressor, Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3', Binds to the POU5F1/OCT4 promoter (PubMed:25825768), Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression, When overexpressed, promotes cells to enter into S phase and proliferation


This is Succinate--hydroxymethylglutarate CoA-transferase protein, from Human, contains 445 amino acids, locates in Mitochondrion.

Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA, Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate

Belongs to the CoA-transferase III family


This is Chromatin modification-related protein MEAF6 protein, from Human, contains 191 amino acids, locates in Nucleus.

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A (PubMed:14966270), This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270), Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653, PubMed:24065767), Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:18794358)


This is Histone deacetylase complex subunit SAP30L protein, from Human, contains 183 amino acids, has 1 Atypical Zinc finger, locates in Nucleus.

Atypical

Functions as transcription repressor; its activity is marginally lower than that of isoform 1


This is Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial protein, from Human, contains 563 amino acids, is soluble, locates in Mitochondrion.

Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism


This is Protein S100-A14 protein, from Human, contains 104 amino acids, is soluble, locates in Cytoplasm.

Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis, Depending on the context, it can promote cell proliferation or apoptosis, Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53, Does not bind calcium


This is G2/mitotic-specific cyclin-B3 protein, from Fruit fly, contains 575 amino acids, locates in Nucleus.

Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division, Probably functions redundantly with other cyclins in regulation of cell cycle, Its presence may be required to delay a deadline for completing cytokinesis that is ordinary imposed by nuclear envelope reformation, Degradation of CycB and CycB3 promote cytokinesis furrow initiation and ingression, Required with CycB for female fertility

Belongs to the cyclin family, Cyclin AB subfamily


This is Forkhead box protein H1 protein, from Zebrafish, contains 472 amino acids, locates in Nucleus.

Transcriptional activator, Activates an activin response element (ARE), Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3', Modulator of nodal signaling required for organizer formation, Also required for the development of dorsal axial structures and left-right symmetry


This is Carboxypeptidase B2 protein, from Mouse, contains 422 amino acids, is soluble, locates in Extracellular.

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities, Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin


This is Retinaldehyde dehydrogenase 3 protein, from Mouse, contains 512 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:11013254, PubMed:11044606, PubMed:14623956, PubMed:15911617), High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (By similarity), Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (PubMed:14623956)

Belongs to the aldehyde dehydrogenase family


This is Thymic stromal lymphopoietin protein, from Mouse, contains 140 amino acids, is soluble, locates in Extracellular.

Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells, Can induce allergic inflammation by directly activating mast cells (By similarity)


This is Neuronal membrane glycoprotein M6-b protein, from Rat, contains 265 amino acids, is membrane-bound, locates in Cell membrane.

May be involved in neural development, Involved in regulation of osteoblast function and bone formation, Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton, May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake

Belongs to the myelin proteolipid protein family


This is Myozenin-2 protein, from Mouse, contains 264 amino acids, is soluble, locates in Cytoplasm.

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere, Plays an important role in the modulation of calcineurin signaling, May play a role in myofibrillogenesis


This is Epidermal growth factor-like protein 6 protein, from Mouse, contains 550 amino acids, is soluble, locates in Extracellular.

May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis, Promotes matrix assembly


This is Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 protein, from Rat, contains 863 amino acids, is membrane-bound, locates in Cell membrane.

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions, Contributes to the native pacemaker currents in heart (If) and in neurons (Ih), Can also transport ammonium in the distal nephron, Produces a large instantaneous current

Belongs to the potassium channel HCN family


This is Zinc transporter 7 protein, from Mouse, contains 378 amino acids, is membrane-bound, locates in Golgi apparatus.

Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed:12446736, PubMed:17954933), By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (By similarity)

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2,A,4) family, SLC30A subfamily


This is DNA-binding protein Rfx5 protein, from Mouse, contains 658 amino acids, locates in Nucleus.

Activates transcription from class II MHC promoters, Recognizes X-boxes, Mediates cooperative binding between RFX and NF-Y, RFX binds the X1 box of MHC-II promoters


This is Serum response factor protein, from Mouse, contains 504 amino acids, locates in Nucleus.

SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS) (PubMed:24732378), Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12732141, PubMed:19350017, PubMed:24732378), The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378), Required for cardiac differentiation and maturation (PubMed:15169892)


This is Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 protein, from Rat, contains 424 amino acids, is membrane-bound, locates in Cell membrane.

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells, Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition, Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins, May be involved in cell adhesion signaling


This is Guard cell S-type anion channel SLAC1 protein, from Mouse-ear cress, contains 556 amino acids, is membrane-bound, locates in Cell membrane.

Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis, Cl(-) efflux through SLAC1 causes membrane depolarization, which activates outward-rectifying K1 channels, leading to KCl and water efflux to reduce turgor further and cause stomatal closure, that reduces water loss and promotes leaf turgor, Essential for stomatal closure in response to CO(2), abscisic acid (ABA), ozone O(3), light/dark transitions, humidity change, calcium ions, hydrogen peroxide H(2)O(2), reactive oxygen species (ROS), and nitric oxide, Binds to the highly selective inward-rectifying potassium channels KAT1 and AKT2, and inhibits their activities, Functions as an essential negative regulator of inward potassium channels in guard cells, Essential for the efficient stomatal closure and opening in guard cells (PubMed:27002025), Involved in the local and/or systemic stomatal responses (e,g, stomatal closure) to light stress (PubMed:29463779)


This is UBP1-associated protein 2A protein, from Mouse-ear cress, contains 478 amino acids, locates in Nucleus.

Heterogeneous nuclear ribonucleoprotein (hnRNP)-like protein that acts as component of a complex regulating the turnover of mRNAs in the nucleus, Binds with high affinity to RNA molecules that contain U-rich sequences in 3'-UTRs, May function in complex with UBP1 and contribute to the stabilization of mRNAs in the nucleus, However, unlike UBP1, UBA2A does not stimulate pre-mRNA splicing


This is Glucosamine 6-phosphate N-acetyltransferase protein, from Mouse-ear cress, contains 149 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Acetyltransferase involved in UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis, UDP-GlcNAc is an essential metabolite that serves as an initial sugar donor for N-glycan synthesis and thus plays an important role in protein and lipid glycosylation

Belongs to the acetyltransferase family, GNA1 subfamily


This is Probable WRKY transcription factor 10 protein, from Mouse-ear cress, contains 485 amino acids, locates in Nucleus.

Transcription factor, Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity), Modulates seed size by negatively regulating the cellularization of syncytial endosperm (PubMed:16293693)


This is Alpha-glucan phosphorylase 1 protein, from Mouse-ear cress, contains 962 amino acids, is soluble, locates in Plastid.

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism, Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates, However, all known phosphorylases share catalytic and structural properties (By similarity), May be not required for the degradation of starch, but the phosphorolysis of starch may play an important role in water stress tolerance

Belongs to the glycogen phosphorylase family


This is PHD finger protein ING1 protein, from Mouse-ear cress, contains 234 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes


This is Adenylate isopentenyltransferase 8, chloroplastic protein, from Mouse-ear cress, contains 330 amino acids, locates in Plastid.

Involved in cytokinin biosynthesis, Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP


This is Cyclin-dependent protein kinase inhibitor SMR1 protein, from Mouse-ear cress, contains 128 amino acids, locates in Nucleus.

Probable cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle (PubMed:17098811, PubMed:26546445), Cooperates with SIM and SMR2 to promote endoreplication during leaf development (PubMed:26546445), Specifically regulates endoreduplication in epidermal pavement cells to produce the cell size pattern (PubMed:20485493), Is necessary for giant cell formation (PubMed:20485493), Positive regulator of effector-triggered immunity (ETI) (PubMed:25455564)


This is GATA transcription factor 25 protein, from Mouse-ear cress, contains 309 amino acids, has 1 GATA-type Zinc finger, locates in Nucleus.

GATA-type

Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters

Belongs to the type IV zinc-finger family, Class C subfamily


This is Armadillo repeat-containing protein LFR protein, from Mouse-ear cress, contains 460 amino acids, locates in Nucleus.

Involved in leaf and flower development (PubMed:18846319), Plays roles in leaf development partly by associating with AS2 and repressing KNAT1/BP transcription (PubMed:29775508), Required for the formation of anther cell layers and normal expression of genes that regulates anther development (PubMed:22461668)


This is Calmodulin-binding transcription activator 6 protein, from Mouse-ear cress, contains 838 amino acids, locates in Nucleus.

Transcription activator that binds calmodulin in a calcium-dependent manner in vitro (PubMed:12218065), Binds to the DNA consensus sequence 5'-[ACG]CGCG[GTC]-3' (By similarity), Regulates transcriptional activity in response to calcium signals (Probable)


This is L-type lectin-domain containing receptor kinase I.9 protein, from Mouse-ear cress, contains 766 amino acids, is membrane-bound, locates in Cell membrane.

Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici

In the N-terminal section; belongs to the leguminous lectin family


This is Long chain base biosynthesis protein 2a protein, from Mouse-ear cress, contains 489 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Serine palmitoyltransferase (SPT), The heterodimer formed with LCB1 constitutes the catalytic core, Involved in the regulation of the programmed cell death (PCD) signaling pathway, Plays an important role during male gametogenesis and embryogenesis

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family


This is Protease Do-like 8, chloroplastic protein, from Mouse-ear cress, contains 448 amino acids, locates in Plastid.


This is S-adenosylmethionine synthase 4 protein, from Mouse-ear cress, contains 393 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the formation of S-adenosylmethionine from methionine and ATP, The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate


This is BAG family molecular chaperone regulator 7 protein, from Mouse-ear cress, contains 446 amino acids, locates in Endoplasmic reticulum.

Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses, Necessary for the proper maintenance of the unfolded protein response (UPR) during heat and cold tolerance


This is Dihydropyrimidine dehydrogenase (NADP(+)), chloroplastic protein, from Mouse-ear cress, contains 426 amino acids, locates in Plastid.

Involved in pyrimidine base degradation, Catalyzes the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate and the reduction of thymine to 5,6-dihydrothymine (DHT), Involved in the recycling of nitrogen from nucleobases to general nitrogen metabolism

Belongs to the dihydropyrimidine dehydrogenase family


This is CLAVATA3/ESR (CLE)-related protein 40 protein, from Mouse-ear cress, contains 80 amino acids, is soluble, locates in Extracellular.

Extracellular signal peptide secreted by differentiated root cells that regulates root cell fate, Acts with ACR4 as a ligand-receptor pair in a signal transduction pathway, coordinating movement of the root tip and organization of cell divisions in the root meristem, Promotes cell differentiation in the distal root meristem in a dose-dependent manner, especially the transition from columella stem cells (CSC) daughters into columella cells (CCs), Induces ACR4 expression in root quiescent center (QC), Involved in WUX5 QC-specific expression pattern regulation, Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2 (PubMed:28607033)

Belongs to the CLV3/ESR signal peptide family


This is Glycosylinositol phosphorylceramide mannosyl transferase 1 protein, from Mouse-ear cress, contains 334 amino acids, is membrane-bound, locates in Golgi apparatus.

Mannosyl transferase (ManT) required for the biosynthesis of mannose-carrying glycosylinositol phosphorylceramides (GIPCs) (PubMed:27895225), Maybe involved in cell-cell adhesion that maintains the integrity of organs by providing mechanical strength and facilitating the movement of metabolites throughout the plant during development (PubMed:16045474), Prevents abscisic acid- (ABA-) mediated effects on development (e,g, cell size, flowering time, senescence), Probably implicated in beta-(1,4)-galactan biosynthesis thus being a cell-wall synthesis-related (CWSR) protein (PubMed:17426055, PubMed:20687615)

Belongs to the glycosyltransferase 64 family


This is Polyamine oxidase 3 protein, from Mouse-ear cress, contains 488 amino acids, locates in Peroxisome.

Flavoenzyme involved in polyamine back-conversion (PubMed:18583528, PubMed:20532512, PubMed:21081665), Catalyzes the oxidation of the secondary amino group of polyamines, such as spermine, spermidine and their acetyl derivatives (PubMed:18583528, PubMed:20532512, PubMed:21081665), Substrate preference is spermidine > spermine > N(1)-acetylspermidine > N(1)-acetylspermine (PubMed:18583528), Plays an important role in the regulation of polyamine intracellular concentration (Probable), Involved in the production of hydrogen peroxide during pollen tube growth (PubMed:20626657), Hydrogen peroxide triggers the opening of the hyperpolarization-activated calcium permeable channels in pollen, and thus regulates pollen tube growth (PubMed:20626657)

Belongs to the flavin monoamine oxidase family


This is Cyclin-dependent protein kinase inhibitor SIM protein, from Mouse-ear cress, contains 127 amino acids, locates in Nucleus.

Cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle (PubMed:10952891, PubMed:11882294, PubMed:17098811, PubMed:17764505, PubMed:19717615, PubMed:20194967), Inhibits the kinase activity of CYCD3-1/CDKA-1, CYCD2-1/CDKA-1 and CYCB1-1/CDKB1-1 complexes in a dose dependent manner (PubMed:26546445), Cooperates with SMR1 and SMR2 to promote endoreplication during leaf development (PubMed:26546445), Required for normal trichome endoreplicating cell cycles (PubMed:10952891, PubMed:11882294, PubMed:17098811, PubMed:17764505, PubMed:19717615, PubMed:20194967), Positive regulator of effector-triggered immunity (ETI) (PubMed:25455564)


This is 1,4-alpha-glucan-branching enzyme 2-2, chloroplastic/amyloplastic protein, from Mouse-ear cress, contains 805 amino acids, is soluble, locates in Plastid.

Catalyzes the formation of the alpha-1,6-glucosidic linkages in starch by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position

Belongs to the glycosyl hydrolase 13 family, GlgB subfamily


This is L-type lectin-domain containing receptor kinase VI.2 protein, from Mouse-ear cress, contains 682 amino acids, is membrane-bound, locates in Cell membrane.

Involved in resistance response to the pathogenic bacteria Pseudomonas syringae


This is Probable RNA-binding protein ARP1 protein, from Mouse-ear cress, contains 261 amino acids, locates in Nucleus.

Probable RNA-binding protein involved in the regulation of abscisic acid (ABA) response during seed germination, May regulate transcript levels of several germination-responsive genes under ABA


This is L-type lectin-domain containing receptor kinase I.3 protein, from Mouse-ear cress, contains 664 amino acids, is membrane-bound, locates in Cell membrane.

Involved in resistance response to the pathogenic fungus Alternaria brassicicola


This is Meiotic recombination protein SPO11-2 protein, from Mouse-ear cress, contains 383 amino acids, locates in Nucleus.

Component of a topoisomerase 6 complex specifically required for meiotic recombination (PubMed:17018031, PubMed:17965269, PubMed:26917763), Together with MTOPVIB, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:26917763, PubMed:19763177), The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (PubMed:17018031, PubMed:17965269, PubMed:26917763)


This is Protein RESTRICTED TEV MOVEMENT 2 protein, from Mouse-ear cress, contains 366 amino acids, is membrane-bound, locates in Cell membrane.

Required for the restriction of long-distance movement of the pathogenic tobacco etch virus (TEV) without causing a hypersensitive response or inducing systemic acquired resistance, Seems to not be involved in heat resistance

Belongs to the small heat shock protein (HSP20) family


This is Thioredoxin-like protein CITRX, chloroplastic protein, from Mouse-ear cress, contains 183 amino acids, locates in Plastid.

Thiol-disulfide oxidoreductase that plays a role in proper chloroplast development, most likely through regulating plastid-encoded polymerase (PEP) dependent chloroplast transcription, Acts as a component of the transcriptionally active plastid chromosome that is required for plastid gene expression

Belongs to the thioredoxin family, Plant CITRX-type subfamily


This is Receptor-like kinase LIP2 protein, from Mouse-ear cress, contains 558 amino acids, is membrane-bound, locates in Cell membrane.

Involved in pollen tube guidance into micropyle, Participates in perception of the ovule-secreted peptide signal LURE1

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is L-type lectin-domain containing receptor kinase S.1 protein, from Mouse-ear cress, contains 656 amino acids, is membrane-bound, locates in Cell membrane.

Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici and to the pathogenic bacteria Pseudomonas syringae


This is VQ motif-containing protein 9 protein, from Mouse-ear cress, contains 311 amino acids, locates in Nucleus.

Functions as a negative regulator of salt stress response, Functions as repressor of WRKY8 transcription factor by decreasing the DNA-binding activity of WRKY8 and acts antagonistically with WRKY8 to regulate sodium and potassium homeostasis under salt stress


This is Granule-bound starch synthase 1, chloroplastic/amyloplastic protein, from Mouse-ear cress, contains 610 amino acids, locates in Plastid.

Required for the synthesis of amylose (PubMed:25710501), Destroyed as it is released from the starch granules during the night (PubMed:15347792), The circadian expression is controlled by CCA1 and LHY transcription factors (PubMed:12777053)

Belongs to the glycosyltransferase 1 family, Bacterial/plant glycogen synthase subfamily


This is Septum site-determining protein minD homolog, chloroplastic protein, from Mouse-ear cress, contains 326 amino acids, is membrane-bound, locates in Plastid.

Together with ARC3 and MCD1, regulates FtsZ ring positioning in chloroplasts in an ARC6-dependent manner (PubMed:29967285, PubMed:28984364, PubMed:23936263), Calcium-dependent ATPase required for the correct placement of the plastid division site, Inhibits FtsZ filament and ring formation in the plastid, Mediates inhibition of plastid division (PubMed:28984364), In cooperation with MINE1, prevents FtsZ ring formation anywhere outside of the mid-plastids

Belongs to the ParA family, MinD subfamily


This is Histone-lysine N-methyltransferase mes-4 protein, from Caenorhabditis elegans, contains 898 amino acids, has 2 PHD-type Zinc finger, locates in Nucleus.

PHD-type

PHD-type

Histone methyltransferase, Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation, Plays a central role in early development and is responsible for all H3 'Lys-36' dimethylation until about the 40-cell stage, Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes (PubMed:12077420, PubMed:16968818), Not related to transcription elongation (PubMed:12077420, PubMed:16968818), Required for small-RNA-induced H3K27 trimethylation (PubMed:26365259), May suppress sensitivity to RNAi (PubMed:16507136), May regulate the expression of genes required for vulval development (PubMed:16507136, PubMed:16710447)

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily


This is Gram-negative bacteria-binding protein 1 protein, from Fruit fly, contains 494 amino acids, is membrane-bound, locates in Cell membrane.

Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria (PubMed:10827089), Upon recognition of invading microorganism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin (PubMed:10827089, PubMed:16399077)

Belongs to the insect beta-1,3-glucan binding protein family


This is Beta-1,3-glucan-binding protein 1 protein, from Tobacco hawkmoth, contains 487 amino acids, is soluble, locates in Extracellular.

Involved in the recognition of invading microorganisms, Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade, Causes aggregation of invading microorganisms


This is BPI fold-containing family A member 1 protein, from Human, contains 256 amino acids, is soluble, locates in Extracellular.

Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608), Plays a role in the innate immune responses of the upper airways (PubMed:23499554, PubMed:23132494), Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P,aeruginosa and K,pneumoniae (PubMed:23499554, PubMed:23132494, PubMed:27145151), Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24124190, PubMed:24043776), Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234), May attract macrophages and neutrophils (PubMed:23132494)

Belongs to the BPI/LBP/Plunc superfamily, Plunc family


This is Solute carrier family 40 member 1 protein, from Human, contains 571 amino acids, is membrane-bound, locates in Cell membrane.

Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:15692071, PubMed:24304836, PubMed:22178646, PubMed:29599243, PubMed:30247984, PubMed:22682227, PubMed:29237594), Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity), Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity), When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342)

Belongs to the ferroportin (FP) (TC 2,A,100) family, SLC40A subfamily


This is Fibroblast growth factor 20 protein, from Human, contains 211 amino acids, is soluble, locates in Extracellular.

Neurotrophic factor that regulates central nervous development and function

Belongs to the heparin-binding growth factors family


This is Interleukin-23 subunit alpha protein, from Human, contains 189 amino acids, is soluble, locates in Extracellular.

Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383), Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (PubMed:32474165, PubMed:29287995, PubMed:33606986), This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A (PubMed:12023369), In turn, participates in the early and effective intracellular bacterial clearance (PubMed:32474165), Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:17676044)


This is Fanconi anemia group F protein protein, from Human, contains 374 amino acids, locates in Nucleus.

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function, May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity)


This is Cartilage acidic protein 1 protein, from Human, contains 661 amino acids, is soluble, locates in Extracellular.


This is Coordinator of PRMT5 and differentiation stimulator protein, from Human, contains 184 amino acids, locates in Nucleus.

Histone-binding protein required for histone H4 methyltransferase activity of PRMT5, Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5, Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5, Involved in CCNE1 promoter repression, Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity)


This is Regulation of nuclear pre-mRNA domain-containing protein 1B protein, from Human, contains 326 amino acids, locates in Nucleus.

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2, Transcriptional regulator which enhances expression of CCND1, Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site, Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop, Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A, Promotes cell proliferation


This is Mitochondrial dynamics protein MIEF1 protein, from Human, contains 463 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial outer membrane protein which regulates mitochondrial fission, Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins, Regulates DNM1L GTPase activity and DNM1L oligomerization, Binds ADP and can also bind GDP, although with lower affinity, Does not bind CDP, UDP, ATP, AMP or GTP, Inhibits DNM1L GTPase activity in the absence of bound ADP, Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP, Does not require ADP for its function in recruiting DNM1L


This is RNA-binding protein PNO1 protein, from Human, contains 252 amino acids, locates in Nucleus.

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797), Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604)


This is Solute carrier family 22 member 11 protein, from Human, contains 550 amino acids, is membrane-bound, locates in Cell membrane.

Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds (PubMed:10660625, PubMed:11907186, PubMed:15291761, PubMed:15037815, PubMed:15102942, PubMed:15576633, PubMed:17229912, PubMed:18501590, PubMed:26277985, PubMed:28027879), May be responsible for placental absorption of fetal-derived steroid sulfates such as estrone sulfate (E1S) and the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S), as well as clearing waste products and xenobiotics from the fetus (PubMed:12409283), Maybe also be involved in placental urate homeostasis (PubMed:17229912), Facilitates the renal reabsorption of organic anions such as urate and derived steroid sulfates (PubMed:15037815, PubMed:17229912), Organic anion glutarate acts as conteranion for E1S renal uptake (PubMed:15037815, PubMed:17229912), Possible transport mode may also include DHEA-S/E1S exchange (PubMed:28027879), Also interacts with inorganic anions such as chloride and hydroxyl ions, therefore possible transport modes may include E1S/Cl(-), E1S/OH(-), urate/Cl(-) and urate/OH(-) (PubMed:17229912), Also mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (PubMed:11907186), Also able to uptake anionic drugs, diuretics, bile salts and ochratoxin A (PubMed:10660625, PubMed:26277985), Mediates the unidirectional efflux of glutamate and aspartate (PubMed:28027879), Glutamate efflux down its transmembrane gradient may drive SLC22A11/OAT4-mediated placental uptake of E1S (PubMed:26277985)

Belongs to the major facilitator (TC 2,A,1) superfamily, Organic cation transporter (TC 2,A,1,19) family


This is Ubiquitin-like-conjugating enzyme ATG3 protein, from Human, contains 314 amino acids, is soluble, locates in Cytoplasm.

E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis, Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A), The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE), This step is required for the membrane association of ATG8-like proteins, The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt), Preferred substrate is MAP1LC3A, Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy, ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3, Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway


This is Acetyl-coenzyme A synthetase 2-like, mitochondrial protein, from Human, contains 689 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062), Acetate is the preferred substrate (PubMed:16788062), Can also utilize propionate with a much lower affinity (By similarity), Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity), Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity)

Belongs to the ATP-dependent AMP-binding enzyme family


This is Protection of telomeres protein 1 protein, from Human, contains 634 amino acids, locates in Nucleus.

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini, Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase, Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus, Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection, Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways, Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence, Binds telomeric single-stranded sequences internally or at proximity of a 3'-end, Its activity is TERT dependent but it does not increase TERT activity by itself, In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity


This is Integrator complex subunit 9 protein, from Human, contains 658 amino acids, locates in Nucleus.

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing, The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable), Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267)

Belongs to the metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, INTS9 subfamily


This is Exonuclease 3'-5' domain-containing protein 2 protein, from Human, contains 621 amino acids, locates in Nucleus.

Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291), In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291), Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528), Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466), Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646), Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646), Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466)


This is Integrator complex subunit 7 protein, from Human, contains 962 amino acids, locates in Nucleus.

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing, The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable), Plays a role in DNA damage response (DDR) signaling during the S phase (PubMed:21659603), May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267)

Belongs to the Integrator subunit 7 family


This is Trimethyllysine dioxygenase, mitochondrial protein, from Human, contains 421 amino acids, is soluble, locates in Mitochondrion.

Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (PubMed:11431483, PubMed:23092983)


This is Guanine nucleotide-binding protein-like 3-like protein protein, from Human, contains 582 amino acids, locates in Nucleus.

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML, Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation, Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase, Required for cell proliferation, By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition, Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation, By acting on MDM2, may affect TP53 activity, Required for normal processing of ribosomal pre-rRNA, Binds GTP

Belongs to the TRAFAC class YlqF/YawG GTPase family


This is Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 protein, from Human, contains 432 amino acids, is membrane-bound, locates in Cell membrane.

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells, Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition, Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins, May be involved in cell adhesion signaling


This is Required for meiotic nuclear division protein 1 homolog protein, from Human, contains 449 amino acids, locates in Mitochondrion.

Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome (PubMed:23022098, PubMed:25604853)


This is Succinate dehydrogenase assembly factor 2, mitochondrial protein, from Human, contains 166 amino acids, is soluble, locates in Mitochondrion.

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol, Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer


This is Cell growth-regulating nucleolar protein protein, from Human, contains 379 amino acids, has 2 C2HC LYAR-type Zinc finger, locates in Nucleus.

C2HC LYAR-type

C2HC LYAR-type

Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227), Also acts at the level of transcription regulation, Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918), In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580), Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918), Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131), In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (PubMed:31413131), Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity), Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity)


This is SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 protein, from Human, contains 954 amino acids, locates in Nucleus.

ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA, Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA), Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA, May play an important role in DNA damage response by acting at stalled replication forks

Belongs to the SNF2/RAD54 helicase family, SMARCAL1 subfamily


This is Alpha-hemoglobin-stabilizing protein protein, from Human, contains 102 amino acids, is soluble, locates in Cytoplasm.

Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development, Specifically protects free alpha-hemoglobin from precipitation, It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia


This is Interleukin-36 gamma protein, from Human, contains 169 amino acids, is soluble, locates in Extracellular.

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells, Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP, Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation, In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous pro-inflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS, May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts, May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus


This is Transcription factor CP2-like protein 1 protein, from Human, contains 479 amino acids, locates in Nucleus.

Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118), With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity), Required for normal duct development in the salivary gland and kidney (By similarity), Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity), Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity), Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity), JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity), Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity), Modulates the placental expression of CYP11A1 (PubMed:10644752)

Belongs to the grh/CP2 family, CP2 subfamily


This is Upstream-binding protein 1 protein, from Human, contains 540 amino acids, locates in Nucleus.

Functions as a transcriptional activator in a promoter context-dependent manner, Modulates the placental expression of CYP11A1, Involved in regulation of the alpha-globin gene in erythroid cells, Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity), Involved in regulation of the alpha-globin gene in erythroid cells, Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box, Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box


This is Complement C1r subcomponent-like protein protein, from Human, contains 487 amino acids, is soluble, locates in Extracellular.

Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum


This is Bifunctional apoptosis regulator protein, from Human, contains 450 amino acids, has 1 RING-type Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type

Apoptosis regulator, Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors


This is Spliceosome-associated protein CWC15 homolog protein, from Human, contains 229 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346), Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing, As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)


This is Kallikrein-14 protein, from Human, contains 267 amino acids, is soluble, locates in Extracellular.

Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity, May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11, May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3, May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface, May be involved in several aspects of tumor progression including growth, invasion and angiogenesis

Belongs to the peptidase S1 family, Kallikrein subfamily


This is Core histone macro-H2A.2 protein, from Human, contains 372 amino acids, locates in Nucleus.

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling, May be involved in stable X chromosome inactivation


This is Vacuolar protein sorting-associated protein 54 protein, from Human, contains 977 amino acids, locates in Golgi apparatus.

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN), The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545), Within the GARP complex, required to tether the complex to the TGN, Not involved in endocytic recycling (PubMed:25799061)


This is E3 ubiquitin-protein ligase MARCHF4 protein, from Human, contains 410 amino acids, has 1 RING-CH-type Zinc finger, is membrane-bound, locates in Golgi apparatus.

RING-CH-type

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is TBC1 domain family member 14 protein, from Human, contains 693 amino acids, locates in Golgi apparatus.

Plays a role in the regulation of starvation-induced autophagosome formation (PubMed:22613832), Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy


This is KAT8 regulatory NSL complex subunit 3 protein, from Human, contains 904 amino acids, locates in Nucleus.

As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription


This is Glutathione S-transferase 3 protein, from Fission yeast, contains 242 amino acids, is soluble, locates in Cytoplasm.

May have a role in the detoxification of various heavy metals


This is Verprolin protein, from Fission yeast, contains 309 amino acids, is soluble, locates in Cytoplasm.

Involved in cytoskeletal organization and cellular growth, May exert its effects on the cytoskeleton directly, or indirectly via proline-binding proteins such as profilin or proteins possessing SH3 domains, Plays a role in actin patch assembly by enhancing the ability of myo1 to stimulate actin polymerization by the Arp2/3 complex


This is Structure-specific endonuclease subunit slx1 protein, from Fission yeast, contains 271 amino acids, has 1 SLX1-type Zinc finger, locates in Nucleus.

Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination, Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA, Has a preference for stem-loop (SL) and splayed arm Y structures, Introduces a single-strand cut in duplex DNA on the 3' side of a double-strand/single-strand junction with respect to the single-strand moving 3' to 5' away from the junction, Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks, The complex initiates homologous recombination (HR) events, used to maintain rDNA copy number, in the rDNA repeats that are processed by a mechanism that requires rad22, but not rhp51, It is also required for suppression of methyl methanesulfonate (MMS) and UV-C irradiation hypersensitivity of the structural maintenance of chromosome (SMC) protein mutant, smc6-74, by overexpression of brc1, Has Holliday junction resolvase activity in vitro


This is Beta-fibrinogenase brevinase protein, from Mamushi, contains 233 amino acids, is soluble, locates in Extracellular.

Snake venom serine protease that has fibrinogenolytic activities, Preferentially cleaves the Bbeta-chain (FGB) and more slowly the Aa-chain (FGA) of fibrinogen, but does not affect the gamma-chain, Has also fibrinolytic activity, May play a role in antithrombotic reaction as well as thrombolytic reaction

Belongs to the peptidase S1 family, Snake venom subfamily


This is Jeltraxin protein, from Budgett's frog, contains 225 amino acids, is soluble, locates in Extracellular.

Calcium-dependent beta-galactose specific lectin


This is YTH domain-containing protein 1 protein, from Rat, contains 738 amino acids, locates in Nucleus.

Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25389274), M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25389274), Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (By similarity), Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (By similarity), In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity), May also regulate alternative splice site selection (PubMed:10564280, PubMed:9473574), Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (By similarity), Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity), Also recognizes and binds m6A on other RNA molecules (By similarity), Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (By similarity), Also recognizes and binds m6A-containing single-stranded DNA (By similarity), Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity)


This is dCTP pyrophosphatase 1 protein, from Mouse, contains 170 amino acids, is soluble, locates in Cytoplasm.

Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates, Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency, May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism


This is cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A protein, from Rat, contains 794 amino acids, is soluble, locates in Cytoplasm.

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides, Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate

Belongs to the cyclic nucleotide phosphodiesterase family


This is Core histone macro-H2A.1 protein, from Mouse, contains 369 amino acids, locates in Nucleus.

In contrast to isoform 1, does not bind poly-ADP-ribose (By similarity), Represses SOD3 gene expression (PubMed:23022728)


This is Golgi reassembly-stacking protein 2 protein, from Rat, contains 454 amino acids, is membrane-bound, locates in Golgi apparatus.

Key structural protein of the Golgi apparatus (By similarity), The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (By similarity), Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (By similarity), However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:23940043), May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (By similarity), Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity), Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity)


This is Ceramide glucosyltransferase protein, from Rat, contains 394 amino acids, is membrane-bound, locates in Golgi apparatus.

Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi, Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) (PubMed:10393098, PubMed:1532799), Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (By similarity), Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction (By similarity), They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions (By similarity), They are required for instance in the proper development and functioning of the nervous system, As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway (By similarity), They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope (By similarity), The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity), Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor (By similarity)

Belongs to the glycosyltransferase 2 family


This is Legumain protein, from Rat, contains 435 amino acids, locates in Lysosome/Vacuole.

Has a strict specificity for hydrolysis of asparaginyl bonds, Can also cleave aspartyl bonds slowly, especially under acidic conditions, Required for normal lysosomal protein degradation in renal proximal tubules, Required for normal degradation of internalized EGFR, Plays a role in the regulation of cell proliferation via its role in EGFR degradation, May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity)


This is Serine/arginine-rich splicing factor 10 protein, from Mouse, contains 262 amino acids, locates in Nucleus.

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing, Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70, Required for splicing repression in M-phase cells and after heat shock, Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing, Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity), May be involved in regulation of alternative splicing in neurons (PubMed:10583508)

Belongs to the splicing factor SR family


This is Stress-associated endoplasmic reticulum protein 1 protein, from Rat, contains 66 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum, Protects unfolded target proteins against degradation during ER stress, May facilitate glycosylation of target proteins after termination of ER stress, May modulate the use of N-glycosylation sites on target proteins


This is Bifunctional L-3-cyanoalanine synthase/cysteine synthase C1, mitochondrial protein, from Mouse-ear cress, contains 368 amino acids, locates in Mitochondrion.

Acts as a major beta-cyanoalanine synthase, The cyanoalanine synthesis reaction is more efficient than the cysteine synthase activity, Probably unable to interact with SAT and to form the decameric Cys synthase complex (CSC) and is therefore not an enzymatically true OASTL protein, Probably involved in the detoxification of cyanide that arises from ethylene biosynthesis, Maintains a low level of cyanide for proper root hair development

Belongs to the cysteine synthase/cystathionine beta-synthase family


This is Isochorismate synthase 1, chloroplastic protein, from Mouse-ear cress, contains 569 amino acids, locates in Plastid.

Isochorismate synthase involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death, Also involved in phylloquinone (vitamin K1) synthesis, Has no isochorismate pyruvate lyase (IPL) activity

Belongs to the isochorismate synthase family


This is ATP-dependent Clp protease proteolytic subunit 5, chloroplastic protein, from Mouse-ear cress, contains 298 amino acids, is soluble, locates in Plastid.

Cleaves peptides in various proteins in a process that requires ATP hydrolysis, Has a chymotrypsin-like activity, Plays a major role in the degradation of misfolded proteins (By similarity)


This is Oxygen-evolving enhancer protein 1-2, chloroplastic protein, from Mouse-ear cress, contains 331 amino acids, is membrane-bound, locates in Plastid.

Stabilizes the manganese cluster which is the primary site of water splitting, Regulates dephosphorylation and turnover of the PSII reaction center D1 protein


This is Sulfite oxidase protein, from Mouse-ear cress, contains 393 amino acids, locates in Peroxisome.

Probably involved in sulfite oxidative detoxification


This is Arogenate dehydratase/prephenate dehydratase 1, chloroplastic protein, from Mouse-ear cress, contains 392 amino acids, is soluble, locates in Plastid.

Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine (PubMed:17726025), Dehydratase that uses arogenate and prephenate as substrates (PubMed:17726025), Utilzes more efficiently arogenate than prephenate (PubMed:17726025)


This is ATP-dependent Clp protease proteolytic subunit 6, chloroplastic protein, from Mouse-ear cress, contains 271 amino acids, is soluble, locates in Plastid.

Cleaves peptides in various proteins in a process that requires ATP hydrolysis, Has a chymotrypsin-like activity, Plays a major role in the degradation of misfolded proteins (By similarity), Essential protein required for chloroplast development and integrity


This is Succinate-semialdehyde dehydrogenase, mitochondrial protein, from Mouse-ear cress, contains 528 amino acids, is soluble, locates in Mitochondrion.

Oxidizes specifically succinate semialdehyde, Involved in plant response to environmental stress by preventing the accumulation of reactive oxygen species, probably by regulating proline, gamma-hydroxybutyrate (GHB) and gamma-aminobutyrate (GABA) levels (PubMed:15642352), Required for the maintenance of the shoot apical meristem (SAM) structure and subsequent adaxial-abaxial axis-dependent development of cotyledons and leaves (PubMed:21690177, PubMed:25840087)

Belongs to the aldehyde dehydrogenase family


This is Myb family transcription factor APL protein, from Mouse-ear cress, contains 358 amino acids, locates in Nucleus.

Transcription factor required for phloem identity, Has a dual role both in promoting phloem differentiation and in repressing xylem differentiation during vascular development, Regulates the expression of the transcription factor NAC045 (AC A4VCM0), May activate the transcription of specific genes involved in phosphate uptake or assimilation (PubMed:15592750), Promotes flowering through transcriptional activation of both FT and its transport machinery component, FTIP1 (PubMed:26239308)


This is AT-hook motif nuclear-localized protein 3 protein, from Mouse-ear cress, contains 404 amino acids, locates in Nucleus.

Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs) (By similarity), Acts redundantly with AHL4 to regulate the formation of tissue boundary between the xylem and procambium in the root meristem (PubMed:23335615)


This is Adenylate isopentenyltransferase 4 protein, from Mouse-ear cress, contains 318 amino acids, is soluble, locates in Cytoplasm.

Involved in cytokinin biosynthesis, Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP, but not to AMP, Has no DMAPP:tRNA isopentenyltransferase activity