This is Transcriptional activator of sulfur metabolism MET4 protein, from Baker's yeast, contains 672 amino acids, locates in Nucleus.

Positive trans-acting factor capable of stimulating the transcription of the MET genes from the methionine biosynthetic pathway, MET4, MET28 and CBF1 are required for full induction of MET25 and MET16 gene transcription, MET4 controls as well the derepression of MET6, Required for the transcription of genes necessary for sulfur amino acid biosynthesis, Involved in the transcription activation of MET28 and MET30, Required for MET3 gene expression via assembly of the MET4-MET28-MET31 and MET4-MET28-MET32 complexes, Involved in response to cadmium and arsenic, Cadmium-activated MET4 also induces glutathione biosynthesis


This is Sodium/calcium exchanger 1 protein, from Human, contains 973 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165), Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:1374913, PubMed:11241183, PubMed:1476165), In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum (PubMed:1374913, PubMed:11241183, PubMed:1476165), SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:1374913, PubMed:11241183, PubMed:1476165), Required for normal embryonic heart development and the onset of heart contractions (By similarity)

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2,A,19) family, SLC8 subfamily


This is Histone chaperone ASF1 protein, from Baker's yeast, contains 279 amino acids, locates in Nucleus.

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:16936140, PubMed:16678113, PubMed:16407267, PubMed:16039596, PubMed:15891116, PubMed:16303565, PubMed:15766286, PubMed:15542829, PubMed:15175160, PubMed:15452122, PubMed:15071494, PubMed:11856374, PubMed:11404324, PubMed:11331602, PubMed:11172707, PubMed:14680630), Facilitates histone deposition through both replication-dependent and replication-independent chromatin assembly pathways (PubMed:14585955, PubMed:16678113, PubMed:15632066), Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with the HIR complex to promote replication-independent chromatin assembly, which may occur during transcription and DNA repair (PubMed:16501045, PubMed:16582440, PubMed:16141196, PubMed:16143623, PubMed:16020781, PubMed:15821127, PubMed:16303565, PubMed:15542840, PubMed:12093919, PubMed:11756556, PubMed:11404324, PubMed:11731480, PubMed:11731479, PubMed:11412995, PubMed:10591219), May be required for the maintenance of a subset of replication elongation factors, including DNA polymerase epsilon, the RFC complex and PCNA, at stalled replication forks (PubMed:15901673, PubMed:11412995), Also required for RTT109-dependent acetylation of histone H3 on 'Lys-9' and 'Lys-56' (PubMed:17320445, PubMed:17107956, PubMed:17046836, PubMed:16815704, PubMed:16627621, PubMed:15840725, PubMed:21256037), Promotion of RTT109-mediated histone H3 'Lys-56' acetylation is dependent on interactions with histone H3 pre-acetylated on 'Lys-14' (PubMed:31194870)


This is Cell wall mannoprotein HSP150 protein, from Baker's yeast, contains 413 amino acids, is soluble, locates in Extracellular.

Component of the outer cell wall layer, Required for stability of the cell wall and for optimal growth, Required for resistance against several antifungal and cell wall-perturbing agents and for tolerance to heat shock


This is Protein HIR2 protein, from Baker's yeast, contains 875 amino acids, locates in Nucleus.

Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly, The HIR complex is also required for the periodic repression of three of the four histone gene loci during the cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B, DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex, The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1


This is Eukaryotic translation initiation factor 3 subunit C protein, from Baker's yeast, contains 812 amino acids, is soluble, locates in Cytoplasm.

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome, The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation


This is Zuotin protein, from Baker's yeast, contains 433 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state, RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain, ZUO1 can act as a J-protein for SSB1/SSB2 only when associated with SSZ1


This is Mediator of RNA polymerase II transcription subunit 17 protein, from Baker's yeast, contains 687 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II, The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins

Belongs to the Mediator complex subunit 17 family


This is Guanosine-diphosphatase protein, from Baker's yeast, contains 518 amino acids, is membrane-bound, locates in Golgi apparatus.

After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol


This is Protein YSC84 protein, from Baker's yeast, contains 468 amino acids, is soluble, locates in Cytoplasm.

Essential for the organization of the actin cytoskeleton, fluid phase endocytosis and vesicle trafficking, together with LSB5


This is NifU-like protein, mitochondrial protein, from Baker's yeast, contains 256 amino acids, is soluble, locates in Mitochondrion.

Involved in iron homeostasis within the mitochondrion where it is involved in the assembly of iron-sulfur proteins (PubMed:10468587, PubMed:27532773), Together with BOL3, required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein (PubMed:27532773), Required for protecting iron sulfur clusters from oxidative damage (PubMed:27532773)


This is Small ribosomal subunit protein uS2A protein, from Baker's yeast, contains 252 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102), uS2 is required for the assembly and/or stability of the 40S ribosomal subunit, Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (PubMed:9973221, PubMed:14627813)

Belongs to the universal ribosomal protein uS2 family


This is Signal recognition particle receptor subunit alpha homolog protein, from Baker's yeast, contains 621 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the SRP (signal recognition particle) receptor (SR), Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system, GTP hydrolysis may enhance the fidelity of and provide unidirectionality to the targeting reaction, It is important but not essential for cell growth, May be directly involved in mitochondrial protein import


This is Pre-mRNA-processing protein PRP40 protein, from Baker's yeast, contains 583 amino acids, locates in Nucleus.

Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing, This protein is associated with snRNP U1, Two commitment complexes, CC1 and CC2, have been defined in yeast, CC1 is a basal complex dependent only on the 5' splice site, CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5' splice site region, This protein is involved in CC2 formation where it binds to the branchpoint binding protein MSL5, bridging the U1 snRNP-associated 5' splice site and the MSL5-associated branch point 3' intron splice site


This is Hsp70/Hsp90 co-chaperone CNS1 protein, from Baker's yeast, contains 385 amino acids, is soluble, locates in Cytoplasm.

Co-chaperone that binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1), Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity, Involved in only a subset of Hsp90 functions


This is Small ribosomal subunit protein eS1A protein, from Baker's yeast, contains 255 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eS1 family


This is Protein transport protein TIP20 protein, from Baker's yeast, contains 701 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for protein transport between the Golgi and the endoplasmic reticulum, May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex


This is B-box type zinc finger protein ncl-1 protein, from Caenorhabditis elegans, contains 851 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger, is soluble, locates in Cytoplasm.

B box-type 1; atypical

B box-type

Translational repressor that inhibits protein synthesis (PubMed:9508766, PubMed:26492166), Represses the translation of mRNAs such as fib-1, probably by being recruited by RNA-binding protein nos-2 and the Pumilio proteins puf-5, puf-8 and puf-9 to the consensus core PUF binding motif in the 3'-UTR of fib-1 mRNA (PubMed:26492166), Negatively regulates ribosomal RNA (rRNA) synthesis, ribosomal protein synthesis and nucleolus size (PubMed:9508766, PubMed:8582642, PubMed:22768349, PubMed:26492166, PubMed:28853436), Its role in the negative regulation of nucleolus size is most likely through its negative regulation of the translation of proteins such as the rRNA 2'-O-methyltransferase fib-1, and dao-5 (PubMed:26492166, PubMed:28853436), Might act directly as a transcription factor to inhibit RNA polymerase I (rRNA) and III (5S RNA) transcription (PubMed:9508766), Plays a role in embryonic development, and in particular, is involved in regulating the localization of proteins, such as par-2, that are required for embryonic cell polarity (PubMed:18652816), Plays a role in the regulation of lifespan, and the response to nutrient availability (PubMed:28853436)


This is Olfactory receptor 1D2 protein, from Human, contains 312 amino acids, is membrane-bound, locates in Cell membrane.

Odorant receptor which may be involved in sperm chemotaxis, Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro, May also function in olfactory reception

Belongs to the G-protein coupled receptor 1 family


This is Histone H2AX protein, from Tetrahymena thermophila (strain SB210), contains 138 amino acids, locates in Nucleus.

Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling


This is Chloride channel protein 1 protein, from Human, contains 988 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-gated chloride channel (PubMed:8112288, PubMed:9122265, PubMed:12456816), Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction, The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (Probable), The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable)

Belongs to the chloride channel (TC 2,A,49) family, ClC-1/CLCN1 subfamily


This is Chloride channel protein 2 protein, from Rat, contains 907 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-gated chloride channel (PubMed:1311421, PubMed:12163466), Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport (PubMed:1311421), Involved in the regulation of aldosterone production, The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (By similarity)

Belongs to the chloride channel (TC 2,A,49) family, ClC-2/CLCN2 subfamily


This is Small ribosomal subunit protein eS27A protein, from Baker's yeast, contains 82 amino acids, has 1 C4-type Zinc finger, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eS27 family


This is Protein EAP1 protein, from Baker's yeast, contains 632 amino acids, is soluble, locates in Cytoplasm.

Can regulate translation through binding to eIF4E, Competes with eIF4G and p20 for binding to eIF4E in vivo and inhibits cap-dependent translation in vitro, Plays a role in cell growth and is implicated in the TOR signaling cascade, Functions independently of eIF4E to maintain genetic stability and to attenuate GCN4 translation upon TOR inactivation


This is Mitochondrial intermembrane space import and assembly protein 40 protein, from Baker's yeast, contains 403 amino acids, is membrane-bound, locates in Mitochondrion.

Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS), Forms a redox cycle with ERV1 that involves a disulfide relay system, Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria, The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS, Reduced MIA40 is reoxidized by FAD-linked sulfhydryl oxidase ERV1


This is Glutathione S-transferase omega-like 2 protein, from Baker's yeast, contains 370 amino acids, is soluble, locates in Cytoplasm.

Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB), May be involved in cell wall organization and biogenesis

Belongs to the GST superfamily, Omega family


This is Meiotic recombination protein rec8 protein, from Fission yeast, contains 561 amino acids, locates in Nucleus.

Involved primarily in the early steps of meiotic recombination, Required to ensure reductional chromosome segregation


This is TGF-beta receptor type-2 protein, from Human, contains 567 amino acids, is membrane-bound, locates in Cell membrane.

Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors, Blocks activation of SMAD2 and SMAD3 by TGFB1

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily


This is Aminodeoxychorismate synthase protein, from Baker's yeast, contains 787 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine, Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis

In the C-terminal section; belongs to the anthranilate synthase component I family


This is Serine/threonine-protein kinase YPK3 protein, from Baker's yeast, contains 525 amino acids, is soluble, locates in Cytoplasm.

AGC kinase which plays a role in TOR complex 1 (TORC1) signaling pathway which mediates temporal control of cell growth in response to nutrients (PubMed:11062466), Required for phosphorylation of ribosomal protein S6 (RPS6A/RPS6B) at 'Ser-232' and 'Ser-233' (PubMed:25767889)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily


This is GPI mannosyltransferase 2 protein, from Baker's yeast, contains 433 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis, Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly


This is Protein RCR1 protein, from Baker's yeast, contains 213 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Regulates chitin deposition in the cell wall


This is Mitochondrial chaperone TCM62 protein, from Baker's yeast, contains 572 amino acids, is membrane-bound, locates in Mitochondrion.

Chaperone, Required for the assembly of succinate dehydrogenase subunits, Ensures mitochondrial gene expression at elevated temperatures and prevents heat-aggregation of the ribosomal subunit VAR1

Belongs to the chaperonin (HSP60) family


This is Protein SLM4 protein, from Baker's yeast, contains 162 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome (PubMed:16732272), Component of the EGO complex, a complex involved in the regulation of microautophagy (PubMed:15989961)


This is Crossover junction endonuclease MMS4 protein, from Baker's yeast, contains 691 amino acids, locates in Nucleus.

Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick, Typical substrates include 3'-flap structures, D-loops, replication forks with regressed leading strands and nicked Holliday junctions, Cleavage probably occurs approximately half a helical turn upstream of the free 5'-end in these structures, May be required in mitosis for the processing of stalled replication fork intermediates arising spontaneously or subsequent to treatment with DNA damaging agents such as methylmethane sulfonate (MMS), camptothecin (CPT) or UV, May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI), This involves consecutive cleavage of D-loops and nicked Holliday junctions leading to sister chromatid crossover, In contrast to MSH4-MSH5 dependent crossover, double Holliday junctions do not seem to be involved, Spore formation and viability are severely impaired in deletion strains


This is Mannosyl phosphorylinositol ceramide synthase CSH1 protein, from Baker's yeast, contains 376 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Involved in the synthesis of mannosyl phosphorylinositol ceramide (PubMed:12954640), Catalyzes the addition of mannosyl to phosphorylinositol ceramide (PubMed:12954640)

Belongs to the glycosyltransferase 32 family


This is Ribonucleases P/MRP protein subunit POP7 protein, from Baker's yeast, contains 140 amino acids, locates in Nucleus.

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends, Also a component of RNase MRP, which cleaves pre-rRNA sequences


This is Iron transporter FTH1 protein, from Baker's yeast, contains 465 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

High affinity iron transporter probably involved in transport of intravacuolar stores of iron

Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9,A,10,1) family


This is Inner kinetochore subunit AME1 protein, from Baker's yeast, contains 324 amino acids, locates in Nucleus.

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis, Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore, COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly


This is Tyrosyl-DNA phosphodiesterase 1 protein, from Baker's yeast, contains 544 amino acids, locates in Nucleus.

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate, Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue, Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals, Cleaves also 5' phosphotyrosyl adducts resulting from dead-end complexes between DNA and the active site tyrosine of topoisomerase II, Contributes to DNA repair after radiation damage, Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA, May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups, Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity)

Belongs to the tyrosyl-DNA phosphodiesterase family


This is Succinate dehydrogenase assembly factor 4, mitochondrial protein, from Baker's yeast, contains 138 amino acids, is soluble, locates in Mitochondrion.

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol, Binds to the flavoprotein subunit SDH1 in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDH2 into the SDH catalytic dimer


This is Uroplakin-3a protein, from Bovine, contains 287 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells, May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells, It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence


This is Mediator of RNA polymerase II transcription subunit 31 protein, from Baker's yeast, contains 127 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II, The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins

Belongs to the Mediator complex subunit 31 family


This is Small ribosomal subunit protein eS27B protein, from Baker's yeast, contains 82 amino acids, has 1 C4-type Zinc finger, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel


This is Ribosome production factor 1 protein, from Baker's yeast, contains 295 amino acids, locates in Nucleus.

Essential protein, Required for biogenesis of the 60S ribosomal subunit


This is Chromatin modification-related protein YNG2 protein, from Baker's yeast, contains 282 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A, The NuA4 complex is also involved in DNA repair, Involved in cell cycle progression and meiosis


This is Chitin synthase export chaperone protein, from Baker's yeast, contains 316 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum


This is Mitochondrial pyruvate carrier 2 protein, from Baker's yeast, contains 129 amino acids, is membrane-bound, locates in Mitochondrion.

Mediates the uptake of pyruvate into mitochondria

Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2,A,105) family


This is Endoplasmic reticulum junction formation protein lunapark protein, from Baker's yeast, contains 278 amino acids, has 1 C4-type; plays a role in ER morphology Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

C4-type; plays a role in ER morphology

Plays a role in tubular endoplasmic reticulum network formation and maintenance, Works in conjunction with the ER shaping proteins (reticulons RTN1 and RTN2, YOP1), and in antagonism to SEY1 to maintain the network in a dynamic equilibrium, May counterbalance SEY1-directed polygon formation by promoting polygon loss through ring closure


This is Transcriptional regulatory protein UME6 protein, from Baker's yeast, contains 836 amino acids, locates in Nucleus.

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Binds to the URS1 site (5'-AGCCGCCGA-3') and recruits the RPD3 histone deacetylase complex to the promoters to negatively regulate the expression of many genes including CAR1 (arginase), several required for sporulation, mating type switching, inositol metabolism, and oxidative carbon metabolism, Recruits also the ISW2 chromatin remodeling complex to promoters in a second gene repression pathway, Associates with the master regulator of meiosis IME1 in order to activate the expression of meiosis genes, Has both a positive and negative role in regulating phospholipid biosynthesis


This is Spindle pole component SPC72 protein, from Baker's yeast, contains 622 amino acids, is soluble, locates in Cytoplasm.

Spindle pole body component that acts as the gamma-tubulin complex-binding protein of the SPB outer plaque, Anchors cytoplasmic microtubules at the at the half bridge of the spindle pole body (SPB) and accordingly functions in nuclear position and spindle orientation, including anaphase spindle migration into the bud, Recruits KIN4 kinase to both SPBs when cytoplasmic microtubules are defective, Links cytoplasmic microtubules with spindle orientation checkpoint (SPOC) components and, therefore, could function as part of the sensors of spindle orientation defects, Is strictly required for mating and karyogamy


This is Nitrogen permease regulator 2 protein, from Baker's yeast, contains 615 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis (PubMed:21454883), Mediates inactivation of the TORC1 complex in response to amino acid starvation (PubMed:19521502, PubMed:26510498), Post-transcriptional regulator of nitrogen permeases (PubMed:19521502), May be involved in putative NPR1-dependent phosphorylation of nitrogen permeases or in the processing and targeting of nitrogen permeases at the level of the endoplasmic reticulum (PubMed:19521502)


This is Eukaryotic initiation factor 4F subunit p130 protein, from Baker's yeast, contains 914 amino acids, is soluble, locates in Cytoplasm.

Component of the eIF4F complex, which interacts with the mRNA cap structure and serves as an initial point of assembly for the translation apparatus, Stimulates translation by interaction with polyadenylate-binding protein PAB1, bringing the 5'- and 3'-ends of the mRNA in proximity, The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability, TIF4632 is probably essential when TIF4631 is missing

Belongs to the eukaryotic initiation factor 4G family


This is Mitochondrial inner membrane protein OXA1 protein, from Baker's yeast, contains 402 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial inner membrane insertase that mediates the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the inner membrane, Links mitoribosomes with the inner membrane (PubMed:22904327), Forms pores capable of accommodating translocating protein segments (PubMed:22829595), Essential for the activity and assembly of cytochrome c oxidase (PubMed:22904327), Plays a central role in the translocation and export of the N-terminal part of the COX2 protein into the mitochondrial intermembrane space


This is Vacuolar protein 8 protein, from Baker's yeast, contains 578 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole


This is Kinetochore protein SPC25 protein, from Baker's yeast, contains 221 amino acids, locates in Nucleus.

Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity


This is Aldehyde dehydrogenase 5, mitochondrial protein, from Baker's yeast, contains 520 amino acids, is soluble, locates in Mitochondrion.

Minor mitochondrial aldehyde dehydrogenase isoform, Plays a role in regulation or biosynthesis of electron transport chain components, Involved in the biosynthesis of acetate during anaerobic growth on glucose

Belongs to the aldehyde dehydrogenase family


This is E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8 protein, from Baker's yeast, contains 274 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

Component of the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 that mediates ubiquitination and subsequent desumoylation of sumoylated proteins and proteins containing SUMO-like domains for their degradation (PubMed:11139495, PubMed:16325482, PubMed:18032921, PubMed:17669696, PubMed:17848550, PubMed:18499666, PubMed:18948542, PubMed:31015336), The STUbL complex SLX5/SLX8 stimulates ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2, and mediates the proteolytic down-regulation of sumoylated proteins (PubMed:18032921), The STUbL complex SLX5/SLX8 is involved in ubiquitin-mediated degradation of histone variant CSE4, preventing mislocalization to euchromatin (PubMed:26960795), The complex plays an essential role in maintenance of chromosome stability and links SUMO-dependent ubiquitination to a centromere-specific function during mitosis (PubMed:23785440), The complex is involved in proteolysis of spindle positioning protein KAR9 and ensures correct spindle function by regulating levels of microtubule-associated proteins (PubMed:26906737), During replication, the complex helps to prevent DNA lesions via recombination and has a role in localizing the DNA damage protein DCD2 (PubMed:16325482, PubMed:17591698), The complex especially ubiquitinates the nuclease YEN1 and prevents persistent accumulation of a fraction of YEN1 associated with sites of activity in late G2/M and helps maintain the balance between pro- and anti-crossover pathways during homologous recombination (PubMed:30479332), It is also involved in ubiquitin-mediated degradation of DNA repair proteins RAD52 and RAD57 (PubMed:18032921), Finally, the complex is recruited to distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots) by the sumoylated transcription factor-like protein EUC1 where it ubiquitinates EUC1 and presumably other targets (PubMed:31015336)


This is Conserved oligomeric Golgi complex subunit 3 protein, from Baker's yeast, contains 801 amino acids, is membrane-bound, locates in Golgi apparatus.

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking, COG is located at the cis- Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events, COG3 is also involved in actin cytoskeleton organization


This is External NADH-ubiquinone oxidoreductase 1, mitochondrial protein, from Baker's yeast, contains 560 amino acids, is soluble, locates in Mitochondrion.

External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol, With NDE2, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions, Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxidation

Belongs to the NADH dehydrogenase family


This is Autophagy-related protein 3 protein, from Baker's yeast, contains 310 amino acids, is soluble, locates in Cytoplasm.

E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy, Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production, Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8, The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE), This step is required for the membrane association of ATG8, The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt), The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy


This is Homoisocitrate dehydrogenase, mitochondrial protein, from Baker's yeast, contains 371 amino acids, locates in Mitochondrion.

Catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate

Belongs to the isocitrate and isopropylmalate dehydrogenases family


This is U3 small nucleolar RNA-associated protein 25 protein, from Baker's yeast, contains 721 amino acids, locates in Nucleus.

DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2


This is DnaJ-like protein 1 protein, from Baker's yeast, contains 432 amino acids, is soluble, locates in Cytoplasm.

Required for peroxisomal protein import which maintains the function of peroxisomes


This is Ribonuclease P protein subunit RPR2 protein, from Baker's yeast, contains 144 amino acids, locates in Nucleus.

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends

Belongs to the eukaryotic/archaeal RNase P protein component 4 family


This is Switch-activating protein 1 protein, from Fission yeast, contains 254 amino acids, locates in Nucleus.

Has a role in chromosome organization and integrity where it is involved in chromosome segregation, Has a role in sister chromatid cohesion and condensation


This is Indolethylamine N-methyltransferase protein, from Mouse, contains 264 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity), Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide, Plays an important role in the detoxification of selenium compounds

Belongs to the class I-like SAM-binding methyltransferase superfamily, NNMT/PNMT/TEMT family


This is Large ribosomal subunit protein eL33B protein, from Baker's yeast, contains 107 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL33 family


This is B-cell lymphoma 6 protein homolog protein, from Mouse, contains 707 amino acids, has 6 C2H2-type Zinc finger, locates in Nucleus.

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions, Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes, Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors, In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155, An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response, In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells, Also required for the establishment and maintenance of immunological memory for both T- and B-cells, Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2, In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners, Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation


This is Transcriptional activator HAC1 protein, from Baker's yeast, contains 238 amino acids, locates in Nucleus.

Transcriptional activator involved in the unfolded protein response (UPR) pathway, Recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes such as KAR2, PDI1, EUG1 and FKB2, Increases the synthesis of endoplasmic reticulum-resident proteins required for protein folding as well as components of the secretory pathway


This is Parathyroid hormone/parathyroid hormone-related peptide receptor protein, from Mouse, contains 591 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for parathyroid hormone and for parathyroid hormone-related peptide (PubMed:8197183), The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system

Belongs to the G-protein coupled receptor 2 family


This is Peroxisomal acyl-coenzyme A thioester hydrolase 1 protein, from Baker's yeast, contains 349 amino acids, locates in Peroxisome.

Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH, Contributes to growth on fatty acids

Belongs to the C/M/P thioester hydrolase family


This is Glutamate receptor ionotropic, kainate 2 protein, from Rat, contains 908 amino acids, is membrane-bound, locates in Cell membrane.

Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (By similarity), Functions in dorsal root ganglion neurons (By similarity)

Belongs to the glutamate-gated ion channel (TC 1,A,10,1) family, GRIK2 subfamily


This is Plastocyanin major isoform, chloroplastic protein, from Mouse-ear cress, contains 167 amino acids, is membrane-bound, locates in Plastid.

Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I, Seems to be the major plastocyanin in Arabidopsis


This is G-box-binding factor 2 protein, from Mouse-ear cress, contains 360 amino acids, locates in Nucleus.

Binds to the G-box motif (5'-CCACGTGG-3') of the rbcS-1A gene promoter, G-box and G-box-like motifs are cis-acting elements defined in promoters of certain plant genes which are regulated by such diverse stimuli as light-induction or hormone control, GBF2 is found to bind asymmetrically to the G-box


This is Excitatory amino acid transporter 3 protein, from Human, contains 524 amino acids, is membrane-bound, locates in Cell membrane.

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949, PubMed:33658209), Can also transport L-cysteine (PubMed:21123949), Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:33658209), Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923), Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949), Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity), Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity), Negatively regulated by ARL6IP5 (By similarity)

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2,A,23) family, SLC1A1 subfamily


This is Hevein-like preproprotein protein, from Mouse-ear cress, contains 212 amino acids, locates in Lysosome/Vacuole.

Fungal growth inhibitors, Neither CB-HEL nor CD-HEL have chitinase activity, but both have antimicrobial activities, CD-HEL has RNase, but no DNase activity


This is Type 1 phosphatases regulator YPI1 protein, from Baker's yeast, contains 155 amino acids, locates in Nucleus.

Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control, Regulates the nuclear localization of type 1 phosphatase GLC7 and SDS22, and is involved in the regulation of mRNA 3'-end processing, May also regulate the activity of type 1 phosphatase PPZ1


This is LAS seventeen-binding protein 3 protein, from Baker's yeast, contains 459 amino acids, is soluble, locates in Cytoplasm.


This is Dermatopontin protein, from Pig, contains 183 amino acids, is soluble, locates in Extracellular.

Seems to mediate adhesion by cell surface integrin binding, May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment, Enhances TGFB1 activity, Inhibits cell proliferation (By similarity), Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation


This is Chondroitin sulfate synthase mig-22 protein, from Caenorhabditis elegans, contains 804 amino acids, is membrane-bound, locates in Golgi apparatus.

Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity, Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity), Required together with sqv-5 for the biosynthesis of chondroitin (PubMed:15485872), Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development (PubMed:15485872, PubMed:16982046), May have a specific role in unc-6/netrin-mediated dorsal guidance of gonadal distal tip cells (PubMed:16982046), Glycosyltransferase activity is weak (PubMed:15485872)

Belongs to the chondroitin N-acetylgalactosaminyltransferase family


This is Protein phosphatase 2C 70 protein, from Mouse-ear cress, contains 581 amino acids, is membrane-bound, locates in Cell membrane.

Dephosphorylates the Ser/Thr receptor-like kinase RLK5, May function as a signaling component in a pathway involving RLK5 (PubMed:15592873), Binds and dephosphorylates CLAVATA1 (CLV1), Functions as a negative regulator of the CLV1 signaling in plant development (PubMed:9294234, PubMed:9701578), Dephosphorylates SERK1 receptor kinase on threonine residues in the A-loop, Dephosphorylation of SERK1 controls SERK1 internalization (PubMed:12101128), Component of a signaling pathway which mediates adaptation to NaCl stress, Is not a component of the SALT OVERLY SENSITIVE (SOS) pathway (PubMed:18162596)


This is Potassium-activated aldehyde dehydrogenase, mitochondrial protein, from Baker's yeast, contains 519 amino acids, is soluble, locates in Mitochondrion.

Potassium-activated aldehyde dehydrogenase involved in acetate formation during anaerobic growth on glucose


This is Small ribosomal subunit protein uS2B protein, from Baker's yeast, contains 252 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102), uS2 is required for the assembly and/or stability of the 40S ribosomal subunit, Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (PubMed:9973221, PubMed:14627813)

Belongs to the universal ribosomal protein uS2 family


This is Translation factor GUF1, mitochondrial protein, from Baker's yeast, contains 645 amino acids, is membrane-bound, locates in Mitochondrion.

Promotes mitochondrial protein synthesis, May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes, Binds to mitochondrial ribosomes in a GTP-dependent manner

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, LepA subfamily


This is Large ribosomal subunit protein uL22B protein, from Baker's yeast, contains 184 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the universal ribosomal protein uL22 family


This is Dihydrosphingosine 1-phosphate phosphatase LCB3 protein, from Baker's yeast, contains 409 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases (PubMed:10477278, PubMed:10563329, PubMed:10856228, PubMed:11278643, PubMed:11967828, PubMed:12493772, PubMed:12684378, PubMed:12786943, PubMed:9195906, PubMed:9353337, PubMed:9419344, PubMed:25345524), Involved in endocytosis and calcium-mediated signaling (PubMed:10856228, PubMed:11278643)

Belongs to the type 2 lipid phosphate phosphatase family


This is Vacuolar amino acid transporter 1 protein, from Baker's yeast, contains 602 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Required for the vacuolar uptake of large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine, Requires ATP for function

Belongs to the amino acid/polyamine transporter 2 family


This is CAAX prenyl protease 1 protein, from Baker's yeast, contains 453 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Proteolytically removes the C-terminal three residues of farnesylated A-factor mating pheromone, Also acts to cleave the N-terminal extension of the pheromone, Does not act on Ras


This is RNA polymerase II holoenzyme cyclin-like subunit protein, from Baker's yeast, contains 323 amino acids, locates in Nucleus.

Component of the SRB8-11 complex, The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription, The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator, It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex, The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5, The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair may also positively and negatively regulate numerous transcriptional activators in response to changes in nutritional and physiological conditions

Belongs to the cyclin family, Cyclin C subfamily


This is Corticotropin-releasing factor receptor 2 protein, from Rat, contains 411 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3, Has high affinity for UCN, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase, Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels


This is Cholesteryl ester transfer protein protein, from Crab-eating macaque, contains 493 amino acids, is soluble, locates in Extracellular.

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles, Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:24293641), Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity)

Belongs to the BPI/LBP/Plunc superfamily, BPI/LBP family


This is Histone H2A.Z protein, from Fission yeast, contains 139 amino acids, locates in Nucleus.

Variant histone H2A which can replace H2A in some nucleosomes, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling, Important for chromosomal structure and function, possibly including a role in controlling the fidelity of chromosomal segregation during mitosis, Plays an important role in maintaining a silenced chromatin state at centromeres and in the architecture of anaphase chromosomes


This is Vasopressin V2 receptor protein, from Bovine, contains 370 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for arginine vasopressin (PubMed:7698346, PubMed:8257689), The activity of this receptor is mediated by G proteins which activate adenylate cyclase, Involved in renal water reabsorption (By similarity)

Belongs to the G-protein coupled receptor 1 family, Vasopressin/oxytocin receptor subfamily


This is ATP-sensitive inward rectifier potassium channel 1 protein, from Human, contains 391 amino acids, is membrane-bound, locates in Cell membrane.

In the kidney, probably plays a major role in potassium homeostasis, Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it, Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages, The inward rectification is mainly due to the blockage of outward current by internal magnesium, This channel is activated by internal ATP and can be blocked by external barium

Belongs to the inward rectifier-type potassium channel (TC 1,A,2,1) family, KCNJ1 subfamily


This is Sodium/calcium exchanger 1 protein, from Bovine, contains 970 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1416984), Contributes to Ca(2+) transport during excitation-contraction coupling in muscle, In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum, SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline, Required for normal embryonic heart development and the onset of heart contractions

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2,A,19) family, SLC8 subfamily


This is Sodium/calcium exchanger 1 protein, from Guinea pig, contains 970 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:7986817), Contributes to Ca(2+) transport during excitation-contraction coupling in muscle, In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum, SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline, Required for normal embryonic heart development and the onset of heart contractions (By similarity)


This is Transcription factor Atoh1 protein, from Mouse, contains 351 amino acids, locates in Nucleus.

Transcriptional regulator, Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1, Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription


This is Large ribosomal subunit protein eL37A protein, from Baker's yeast, contains 88 amino acids, has 1 C4-type Zinc finger, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eL37 family


This is DNA replication licensing factor MCM2 protein, from Human, contains 904 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232), The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425), Required for the entry in S phase and for cell division (PubMed:8175912), Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677)


This is Maternal DNA replication licensing factor mcm3 protein, from African clawed frog, contains 807 amino acids, locates in Nucleus.

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development


This is Kallikrein-7 protein, from Human, contains 253 amino acids, is soluble, locates in Extracellular.

May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface, Specific for amino acid residues with aromatic side chains in the P1 position, Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27', Could play a role in the activation of precursors to inflammatory cytokines

Belongs to the peptidase S1 family, Kallikrein subfamily


This is Transcription factor HNF-4 homolog protein, from Fruit fly, contains 704 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Transcriptionally controlled transcription factor, Important for the differentiation of various specialized cell types that arise from both endoderm and mesoderm, May have a role in early gut formation, Plays an essential role in lipid catabolism, regulating lipid mobilization and beta-oxidation in response to nutrient deprivation

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Protein ZDS1 protein, from Baker's yeast, contains 915 amino acids, is soluble, locates in Cytoplasm.

When associated with DBP5, GFD1 and nucleoporins at the cytosolic fibrils of the nuclear pore complex, is required for mRNA export form the nucleus


This is Parathyroid hormone/parathyroid hormone-related peptide receptor protein, from Pig, contains 585 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for parathyroid hormone and for parathyroid hormone-related peptide, The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system

Belongs to the G-protein coupled receptor 2 family


This is Emerin protein, from Human, contains 254 amino acids, is membrane-bound, locates in Nucleus.

Stabilizes and promotes the formation of a nuclear actin cortical network, Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments, Inhibits beta-catenin activity by preventing its accumulation in the nucleus, Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway, Links centrosomes to the nuclear envelope via a microtubule association, Required for proper localization of non-farnesylated prelamin-A/C, Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640), EMD and BAF are cooperative cofactors of HIV-1 infection, Association of EMD with the viral DNA requires the presence of BAF and viral integrase, The association of viral DNA with chromatin requires the presence of BAF and EMD


This is Protein male-specific lethal-3 protein, from Fruit fly, contains 512 amino acids, locates in Nucleus.

The MSL proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation), Mle, msl-1 and msl-3 are colocalized on the X chromosome, Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding


This is Cell cycle serine/threonine-protein kinase hsk1 protein, from Fission yeast, contains 507 amino acids, locates in Nucleus.

Required for G1/S transition, Plays a role in DNA replication checkpoint signaling through regulating rad3 and cds1, Involved in the maintenance of mitotic chromosome structures during S phase through regulating the function of rad21, Required for initiation of mitotic DNA replication through phosphorylating mcm2/cdc19, Required for genome integrity

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CDC7 subfamily


This is Large ribosomal subunit protein eL37B protein, from Baker's yeast, contains 88 amino acids, has 1 C4-type Zinc finger, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel


This is Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial protein, from Human, contains 393 amino acids, locates in Mitochondrion.

Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate, The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers

Belongs to the isocitrate and isopropylmalate dehydrogenases family


This is Cytoplasmic tyrosine-protein kinase BMX protein, from Human, contains 675 amino acids, has 1 Btk-type Zinc finger, is soluble, locates in Cytoplasm.

Btk-type

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis, Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins, Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation, Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility, Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis, Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation, Also involved in interleukin-6 (IL6) induced differentiation, Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts, May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1, May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells

Belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily


This is ATP-sensitive inward rectifier potassium channel 12 protein, from Rat, contains 427 amino acids, is membrane-bound, locates in Cell membrane.

Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells, Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues, Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it, Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages, The inward rectification is mainly due to the blockage of outward current by internal magnesium

Belongs to the inward rectifier-type potassium channel (TC 1,A,2,1) family, KCNJ12 subfamily


This is Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 protein, from Human, contains 882 amino acids, is membrane-bound, locates in Golgi apparatus.

Lacks both N-deacetylase and N-sulfotransferase activities, Acts as a dominant negative on isoform 1, likely by changing the composition of enzyme complexes responsible for elongation and modification of heparan sulfates

Belongs to the sulfotransferase 1 family, NDST subfamily


This is Decapping nuclease RAI1 protein, from Baker's yeast, contains 387 amino acids, locates in Nucleus.

Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity), The NAD-cap is present at the 5'-end of some RNAs and snoRNAs, In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity), Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (PubMed:12897126, PubMed:20802481, PubMed:26101253), Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (PubMed:12897126, PubMed:20802481), Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (PubMed:20802481), Stimulates exoribonuclease activity of RAT1, allowing it to degrade RNAs with stable secondary structure more effectively (PubMed:20802481), Required for the processing of nuclear mRNA and rRNA precursors (PubMed:10805743, PubMed:12612077, PubMed:16131592), May promote termination of transcription by RNA polymerase II (PubMed:15565157)


This is Mitochondrial distribution and morphology protein 34 protein, from Baker's yeast, contains 459 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria (PubMed:11907266, PubMed:14981098), Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria (PubMed:27469264), MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10 (By similarity) (PubMed:19556461)


This is Protein YIP4 protein, from Baker's yeast, contains 235 amino acids, is membrane-bound, locates in Golgi apparatus.

May be involved in proper membrane localization of Rab GTPases


This is UDP-N-acetylglucosamine transferase subunit ALG13 protein, from Baker's yeast, contains 202 amino acids, locates in Endoplasmic reticulum.

Involved in protein N-glycosylation, Essential for the second step of the dolichol-linked oligosaccharide pathway

Belongs to the glycosyltransferase 28 family


This is J-type co-chaperone JAC1, mitochondrial protein, from Baker's yeast, contains 184 amino acids, is soluble, locates in Mitochondrion.

Co-chaperone required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria, Stimulates the ATPase activity of its specialized Hsp70 chaperone partner SSQ1, to mediate the transfer of iron-sulfur clusters from ISU1 to GRX5, Binds to the substrate protein ISU1 and targets it to SSQ1


This is Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating protein, from Baker's yeast, contains 349 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Sterol-4-alpha-carboxylate 3-dehydrogenase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:9811880, PubMed:15995173), ERG26 is a catalytic component of the C-4 demethylation complex that catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group (PubMed:9811880), The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane, Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids, Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis, Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis, Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core, In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions, The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis, The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol, 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3, ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25, Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol, The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol, The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol, The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain, Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (PubMed:32679672)


This is Dolichyldiphosphatase protein, from Baker's yeast, contains 239 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Non-essential protein which is required for efficient N-glycosylation, Necessary for maintaining optimal levels of dolichol-linked oligosaccharides, Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate, Does not act on phosphatidate

Belongs to the dolichyldiphosphatase family


This is Chromatin structure-remodeling complex subunit RSC1 protein, from Baker's yeast, contains 928 amino acids, locates in Nucleus.

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, This subunit is involved in meiotic sporulation through regulating IME2 expression


This is Rhomboid protein 1, mitochondrial protein, from Baker's yeast, contains 346 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial rhomboid serine protease processing the mitochondrial membrane fusion regulator MGM1, and the cytochrome c peroxidase (CCP1), Required for TIM11 stability, ATP synthase complex assembly, mitochondrial morphology, cytochrome c (CYC1) storage and mitochondrial genome maintenance


This is Inner kinetochore subunit OKP1 protein, from Baker's yeast, contains 406 amino acids, locates in Nucleus.

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis, Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore, COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly


This is Mitochondrial pyruvate carrier 3 protein, from Baker's yeast, contains 146 amino acids, is membrane-bound, locates in Mitochondrion.

Mediates the uptake of pyruvate into mitochondria

Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2,A,105) family


This is 2',3'-cyclic-nucleotide 3'-phosphodiesterase protein, from Baker's yeast, contains 239 amino acids, locates in Golgi apparatus.

Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing

Belongs to the 2H phosphoesterase superfamily, CPD1 family


This is Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial protein, from Baker's yeast, contains 479 amino acids, is membrane-bound, locates in Mitochondrion.

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis, Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB), The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via ferredoxin (YAH1) and ferredoxin reductase (ARH1) to COQ6 (PubMed:21944752), Can also convert 3-hexaprenyl-4-aminobenzoic acid (HAB), a COQ2-prenylated pABA, to DHHB in a two step process, HAB is first hydroxylated at C5 to yield 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) which is further deaminated at C4 by COQ6 to produce DHHB (PubMed:26260787)


This is Regulator of Ty1 transposition protein 102 protein, from Baker's yeast, contains 157 amino acids, locates in Nucleus.

Probable component of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, Probable component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes, It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors


This is Respiratory supercomplex factor 2, mitochondrial protein, from Baker's yeast, contains 224 amino acids, is membrane-bound, locates in Mitochondrion.

Assembly factor that plays a role in the assembly of the respiratory chain supercomplexes (SCs) composed of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), May be required for late-stage assembly of the COX12 and COX13 subunits (PubMed:22342701, PubMed:22310663), Required for the generation and maintenance of a normal proton motive force (PMF) across the inner mitochondrial membrane (IMM) by preventing proton leakage through an inactive population of CIV that accumulates when RCF1 and/or RCF2 proteins are absent (PubMed:30683696, PubMed:31591265)


This is M-phase phosphoprotein 6 homolog protein, from Baker's yeast, contains 186 amino acids, locates in Nucleus.

Involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA) derived from intergenic regions and the ribosomal DNA spacer heterochromatin, Binds RNA


This is Ribonucleases P/MRP protein subunit POP3 protein, from Baker's yeast, contains 195 amino acids, locates in Nucleus.

Required for processing of 5,8S rRNA (short form) at site A3 and for 5'- and 3'-processing of pre-tRNA


This is Chaotic nuclear migration protein 67 protein, from Baker's yeast, contains 581 amino acids, is soluble, locates in Cytoplasm.

Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation, Required for the proper formation of the spindle pole body (SPB) outer plaque, May connect the outer plaque to the central plaque embedded in the nuclear envelope


This is Probable glutamine amidotransferase DUG3 protein, from Baker's yeast, contains 357 amino acids, is soluble, locates in Cytoplasm.

Component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond


This is Cytoplasmic tRNA 2-thiolation protein 2 protein, from Baker's yeast, contains 493 amino acids, is soluble, locates in Cytoplasm.

Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln), May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position, Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation, May also be involved in protein urmylation and in invasive and pseudohyphal growth, Inhibits replication of Brome mosaic virus


This is Actin-regulating kinase 1 protein, from Baker's yeast, contains 638 amino acids, is soluble, locates in Cytoplasm.

Involved in regulation of actin cytoskeleton organization and endocytosis

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Transcriptional activator/repressor MOT3 protein, from Baker's yeast, contains 490 amino acids, has 2 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor that affects the expression of a large set of genes, Recognizes and binds to the consensus sequence 5'-[CAT]AGG[TC]A-3' in the promoter region, Plays a major role in the repression of a specific subset of hypoxic genes (e,g, ANB1, DAN1 and HEM13) under aerobic conditions, Acts synergistically with the transcription factor ROX1 to recruit the general repression complex SSN6-TUP1 to the promoter of hypoxic genes, Represses transcription of ergosterol biosynthetic genes, Negatively regulates pheromone-induced gene expression, Can act as a transcriptional activator (e,g, of genes like CYC1, SUC2 and the Ty long terminal repeat delta promoter)


This is Small ribosomal subunit protein eS1 protein, from Fruit fly, contains 268 amino acids, is soluble, locates in Cytoplasm.

Essential for oogenesis; required for late follicle cell development

Belongs to the eukaryotic ribosomal protein eS1 family


This is DNA replication licensing factor mcm2 protein, from African clawed frog, contains 886 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, Required for the entry in S phase and for cell division


This is Isocitrate dehydrogenase [NADP], mitochondrial protein, from Rat, contains 452 amino acids, locates in Mitochondrion.

Plays a role in intermediary metabolism and energy production, It may tightly associate or interact with the pyruvate dehydrogenase complex


This is Splicing regulator RBM11 protein, from Human, contains 281 amino acids, is soluble, locates in Nucleus.

Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation, Antagonizes SRSF1-mediated BCL-X splicing, May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1


This is Transmembrane protease serine 3 protein, from Human, contains 454 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Probable serine protease that plays a role in hearing, Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity), Activates ENaC (in vitro)


This is Cysteine/serine-rich nuclear protein 3 protein, from Mouse, contains 597 amino acids, locates in Nucleus.

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity, Plays a role in apoptosis


This is Mitochondrial coiled-coil domain protein 1 protein, from Human, contains 119 amino acids, locates in Mitochondrion.


This is Beta-defensin 1 protein, from Human, contains 68 amino acids, is soluble, locates in Extracellular.

Has bactericidal activity, May act as a ligand for C-C chemokine receptor CCR6, Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner, Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636)


This is Rho-related GTP-binding protein RhoE protein, from Mouse, contains 244 amino acids, is membrane-bound, locates in Golgi apparatus.

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins

Belongs to the small GTPase superfamily, Rho family


This is Beta-2-microglobulin protein, from Human, contains 119 amino acids, has 1 Ig-like C1-type Immunoglobulin domain, is soluble, locates in Extracellular.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system, Exogenously applied M,tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553)

Belongs to the beta-2-microglobulin family


This is WD repeat-containing protein 5 protein, from Human, contains 334 amino acids, locates in Nucleus.

Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960), May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960), As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245), H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606), As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852), May regulate osteoblasts differentiation (By similarity), In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653)

Belongs to the WD repeat WDR5/wds family


This is WD repeat-containing protein 5 protein, from Mouse, contains 334 amino acids, locates in Nucleus.

Contributes to histone modification (By similarity), May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity), As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity), H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity), As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity), May regulate osteoblasts differentiation (PubMed:11551928), In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity)


This is DNA-directed RNA polymerase II subunit RPB7 protein, from Human, contains 172 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs, Pol II is the central component of the basal RNA polymerase II transcription machinery, It is composed of mobile elements that move relative to each other, RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element, The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft, The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity), Binds RNA

Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family


This is DNA-directed RNA polymerases I, II, and III subunit RPABC5 protein, from Human, contains 67 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively, Pol II is the central component of the basal RNA polymerase II transcription machinery, Pols are composed of mobile elements that move relative to each other, In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity)

Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family


This is Alpha-pompilidotoxin protein, from Solitary wasp, contains 56 amino acids, is soluble, locates in Extracellular.

Inhibits sodium channels (Nav) inactivation, Shows two types of inhibitory activities on channels, Inhibition of hNav1,6/SCN8A shows a large increase in the steady-state current component without any increase in the slow component, whereas inhibition of hNav1,1/SCN1A, hNav1,2/SCN2A, hNav1,3/SCN3A and hNav1,7/SCN9A shows a large increase in the slow component with only a small steady-state component (PubMed:20059541), Is 5-fold less potent than beta-PMTX for inducing repetitive action potentials in lobster neuromuscular junctions


This is Cerberus protein, from African clawed frog, contains 270 amino acids, is soluble, locates in Extracellular.

Inhibits wnt, nodal/nr-1 and bmp signaling in the embryo to promote head formation and anterior neural induction, Within the endoderm, acts as an essential mediator of nodal/nr-1-induced cardiogenesis in the overlying mesoderm


This is Forkhead box protein H1 protein, from African clawed frog, contains 518 amino acids, locates in Nucleus.

Transcriptional activator, Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3', Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin-responsive factor 1 (ARF1), which binds a site on the mix-B/mix,2 promoter called the activin response element (ARE), Binds to activated smads and the ARE with much lower affinity than fast3, Necessary for the first steps in mesoderm specification, directly inducing mesodermal genes, Acts with fast3 to control the convergent extension movements of gastrulation, Binds to the proximal element (PE) of the gsc gene and cooperates with gtf2ird1/wbscr11 and SMAD proteins to regulate gsc transcription


This is Acid sphingomyelinase-like phosphodiesterase 3a protein, from Mouse, contains 445 amino acids, is soluble, locates in Extracellular.

Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:26792860), Has in vitro activity with p-nitrophenyl-TMP, Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates, Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine, Has in vitro activity with CDP-ethanolamine, Does not have sphingomyelin phosphodiesterase activity (By similarity)

Belongs to the acid sphingomyelinase family


This is Surfeit locus protein 6 protein, from Mouse, contains 355 amino acids, is soluble, locates in Nucleus.

Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA, May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly


This is Synaptonemal complex protein 3 protein, from Mouse, contains 254 amino acids, locates in Nucleus.

Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:11311943, PubMed:22761579), Required for centromere pairing during meiosis in male germ cells (PubMed:22761579), Required for normal meiosis during spermatogenesis and male fertility (PubMed:10678170), Plays a lesser role in female fertility (PubMed:10678170, PubMed:12004129), Required for efficient phosphorylation of HORMAD1 and HORMAD2 (PubMed:22346761)