This is Cyclin-dependent kinase inhibitor 2 protein, from Mouse-ear cress, contains 209 amino acids, is soluble, locates in Nucleus.

Binds and inhibits CYCD2-1/CDKA-1 complex kinase activity, Regulates cell division which is crucial for plant growth, development and morphogenesis, May regulate early lateral root initiation by blocking the G1/S phase transition, Controls the mitosis-to-endocycle transition and the onset of the endoreduplication cycle during leaf development through inhibition of mitotic CDKA-1 kinase complexes, Specifically targets CDKA-1

Belongs to the CDI family, ICK/KRP subfamily


This is Peptidyl-prolyl cis-trans isomerase FKBP13, chloroplastic protein, from Mouse-ear cress, contains 208 amino acids, locates in Plastid.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, Responsive of the major PPIase activity in the chloroplast thylakoid lumen, Regulates the accumulation of Rieske protein, an essential component of the photosynthetic electron transport chain


This is Photosynthetic NDH subunit of lumenal location 4, chloroplastic protein, from Mouse-ear cress, contains 217 amino acids, locates in Plastid.

NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain, The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone, Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (Probable), PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity), Seems to be essential for stabilizing the NDH subcomplex A (PubMed:19903870)


This is Trihelix transcription factor GT-3a protein, from Mouse-ear cress, contains 323 amino acids, locates in Nucleus.

Probable transcription factor that binds specifically to the core DNA sequence 5'-GTTAC-3'


This is Protease Do-like 5, chloroplastic protein, from Mouse-ear cress, contains 323 amino acids, locates in Plastid.


This is Katanin p60 ATPase-containing subunit A1 protein, from Mouse-ear cress, contains 523 amino acids, is soluble, locates in Cytoplasm.

Severs microtubules in vitro in an ATP-dependent manner, Required for oligomerization of functional KTN80-KTN1 complexes that catalyze microtubule severing (PubMed:28978669), This activity may promote rapid reorganization of cellular microtubule arrays, May be required for reorientation of cortical microtubule arrays during cellular elongation, Failure to correctly orient these arrays drastically compromises fiber length, cell wall thickness and mechanical strength, May also be required for the spatial organization of developmental cues within the root

Belongs to the AAA ATPase family, Katanin p60 subunit A1 subfamily


This is High mobility group B protein 9 protein, from Mouse-ear cress, contains 338 amino acids, locates in Nucleus.

Binds preferentially DNA with A/T-rich content (PubMed:19053246), Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus (PubMed:16698901)


This is Glycerol-3-phosphate acyltransferase 1 protein, from Mouse-ear cress, contains 585 amino acids, is membrane-bound, locates in Mitochondrion.

Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis, Involved in pollen development, by being required for tapetum differentiation and male fertility, In addition to the sporophytic effect, it also exerts a gametophytic effect on pollen performance


This is Endonuclease III homolog 1, chloroplastic protein, from Mouse-ear cress, contains 379 amino acids, is soluble, locates in Plastid.

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage, The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site, The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, Primarily recognizes and repairs oxidative base damage of pyrimidines


This is B-box zinc finger protein 25 protein, from Mouse-ear cress, contains 238 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger, locates in Nucleus.

B box-type 1; atypical

B box-type 2; atypical

Acts as negative regulator of seedling photomorphogenesis (PubMed:18540109), BBX25/STH and BBX24/STO function as transcriptional corepressors of HY5 activity, leading to the down-regulation of BBX22 expression, BBX25/STH acts additively with BBX24/STO during de-etiolation and the hypocotyl shade avoidance response (PubMed:23624715)


This is F-box protein MAX2 protein, from Mouse-ear cress, contains 693 amino acids, locates in Nucleus.

Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins, Promotes the senescence, Is necessary for responses to strigolactones and karrikins, Contributes to the selective repression of axillary shoots and moderates the branching by regulating negatively the auxin transport in primary stems, in an AXR1-independent manner (PubMed:11487692, PubMed:11874909, PubMed:15737939, PubMed:16546078, PubMed:22357928, PubMed:9351240), Required for the progression of leaf senescence mediated by methyl jasmonate (PubMed:26507893), Required at each node to suppress axillary bud growth (PubMed:17346265)


This is Protein CHROMATIN REMODELING 35 protein, from Mouse-ear cress, contains 888 amino acids, locates in Nucleus.

Subunit of the chromatin-remodeling complex (DDR complex) that mediates RNA polymerases IV and V (Pol IV and Pol V) recruitment to chromatin (PubMed:19013275, PubMed:22864289), Cooperates with Pol IV and Pol V to regulates RNA- and RNAi- (RNA interference) directed non-CpG de novo DNA methylation on cytosine of genes targeted for silencing and enhancers, also known as siRNA-directed DNA methylation (RdDM), thus leading to epigenetic modification of the genome and promoting/maintaining heterochromatin (PubMed:15120073, PubMed:15947783, PubMed:15924141, PubMed:16724114, PubMed:16741558, PubMed:19204117, PubMed:19825647, PubMed:22647529, PubMed:18425128), In collaboration with Pol V, mediates/maintains, in cis, methylation-associated self-silencing of exogenous transgene transcribing inverted-repeat (exo-IR) silencer (exo-Pdsi) to restrain exo-IR dsRNA accumulation and subsequent inappropriate silencing of active protein-coding genes (e,g, PDS) by exo-IR-derivating 24-nt siRNAs (PubMed:21771120), Also required to mediate loss of CpG methylation when the silencing inducer is withdrawn (PubMed:15947783), Required for the maintenance of retrotransposon large terminal repeats (LTRs) and transposable elements (TE) edges silencing mediated by cytosine methylation (PubMed:16724114, PubMed:23540698), Required for transcriptional repression of specific classes of pericentromeric 180-bp repeats by promoting condensation and histone H3 lysine 9 dimethylation (H3K9me2) at chromocenters (PubMed:19825650), Required for basal resistance against the necrotrophic fungal pathogen Plectosphaerella cucumerina (PubMed:22242006)


This is B-box zinc finger protein 18 protein, from Mouse-ear cress, contains 172 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger, locates in Nucleus.

B box-type 1; atypical

B box-type 2; atypical

Acts as negative regulator of seedling photomorphogenesis (PubMed:18540109), Acts as a negative regulator of blue light-mediated inhibition of hypocotyl elongation through increase of bioactive gibberellin levels (PubMed:20872270), Acts as a repressor of thermotolerance by modulating expression of a set of heat shock-responsive genes (PubMed:23238922)


This is Protein SPIRAL1 protein, from Mouse-ear cress, contains 119 amino acids, is soluble, locates in Cytoplasm.

Required for directional control of cell elongation, Stabilizes growing ends of cortical microtubules and influences their dynamic properties, Acts redundantly with SP1Ls in maintaining the cortical microtubules organization essential for anisotropic cell growth, Plays a key role in salt stress-induced microtubules disassembly


This is Transcription factor IBH1 protein, from Mouse-ear cress, contains 156 amino acids, locates in Nucleus.

Atypical and probable non DNA-binding bHLH transcription factor that acts as transcriptional repressor that negatively regulates cell and organ elongation in response to gibberellin (GA) and brassinosteroid (BR) signaling, Is able to form heterodimer with BHLH49, thus inhibiting DNA binding of BHLH49, which is a transcriptional activator that regulates the expression of a subset of genes involved in cell expansion by binding to the G-box motif, Binds and inhibits HBI1, a positive regulator of cell elongation that directly binds to the promoters and activated the two expansin genes EXPA1 and EXPA8, encoding cell wall loosening enzymes, The ability of IBH1 to inhibit BHLH49 and HBI1 is counteracted by binding to the antagonist bHLH transcription factor PRE1, restoring the transcriptional activity of BHLH49 and HBI1 and resulting in induction of cell elongation, Functions redundantly with IBL1/BHLH159 in a regulation node known as the incoherent feed-forward loop (FFL) (PubMed:24505057)


This is Polyamine oxidase 2 protein, from Mouse-ear cress, contains 490 amino acids, locates in Peroxisome.

Flavoenzyme involved in polyamine back-conversion (PubMed:20532512, PubMed:21081665), Catalyzes the oxidation of the secondary amino group of polyamines, such as spermine, spermidine and their acetyl derivatives (PubMed:20532512, PubMed:21081665), Substrate preference is N(1)-acetylspermine > spermine > spermidine (PubMed:21081665), Plays an important role in the regulation of polyamine intracellular concentration (Probable), Involved in abscisic acid-mediated developmental processes (PubMed:26310141), May contribute to nitric oxide-mediated effects on root growth (PubMed:26310141)

Belongs to the flavin monoamine oxidase family


This is Tubulin-folding cofactor C protein, from Mouse-ear cress, contains 345 amino acids, is soluble, locates in Cytoplasm.

Essential tubulin-folding protein involved in the final step of the tubulin folding pathway, Required for continuous microtubule cytoskeleton organization, mitotic division, cytokinesis, and to couple cell cycle progression to cell division in embryos and endosperms, Not essential for cell viability, Binds probably to the multimeric supercomplex, stimulating GTP hydrolysis by the bound beta-tubulin and the release of the alpha-/beta-tubulin heterodimer


This is Mitochondrial outer membrane protein porin 3 protein, from Mouse-ear cress, contains 274 amino acids, is membrane-bound, locates in Mitochondrion.

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules, The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV, The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity)

Belongs to the eukaryotic mitochondrial porin (TC 1,B,8,1) family


This is Fasciclin-like arabinogalactan protein 4 protein, from Mouse-ear cress, contains 420 amino acids, is membrane-bound, locates in Cell membrane.

May be a cell surface adhesion protein that is required for normal cell expansion

Belongs to the fasciclin-like AGP family


This is Transcription factor MYB28 protein, from Mouse-ear cress, contains 366 amino acids, locates in Nucleus.

Major regulator of short-chained aliphatic glucosinolates (GLSs) biosynthesis, Together with MYB29/HAG3 and MYB76/HAG2, promotes aliphatic glucosinolate biosynthesis but represses indolic glucosinolate biosynthesis, Prevents insect performance (e,g, lepidopteran insect Mamestra brassicae and Spodoptera exigua) by promoting glucosinolates


This is Transcription factor MYB24 protein, from Mouse-ear cress, contains 214 amino acids, locates in Nucleus.

Transcription factor acting redundantly with MYB21 and MYB57 to control stamen filament elongation in the late developed flowers, Contributes with MYB21 to induction of MYB108 by jasmonate, Repressed at the transcript levels by DELLA proteins


This is Apyrase 2 protein, from Mouse-ear cress, contains 472 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates, Substrate preference is ATP > ADP, Functions with APY1 to reduce extracellular ATP level which is essential for pollen germination and normal plant development, Plays a role in the regulation of stomatal function by modulating extracellular ATP levels in guard cells


This is Apyrase 1 protein, from Mouse-ear cress, contains 471 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates, Substrate preference is ATP > ADP, Functions with APY2 to reduce extracellular ATP level which is essential for pollen germination and normal plant development, Plays a role in the regulation of stomatal function by modulating extracellular ATP levels in guard cells


This is Mitochondrial outer membrane protein porin 1 protein, from Mouse-ear cress, contains 276 amino acids, is membrane-bound, locates in Mitochondrion.

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules, The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV, The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity), Involved in plant development at reproductive stage, is important for pollen development and may regulate hydrogen peroxide generation during disease resistance


This is Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic protein, from Mouse-ear cress, contains 437 amino acids, locates in Plastid.

Required for the assembly and stabilization of PSII, but has no PPIases activity


This is Protein TOO MANY MOUTHS protein, from Mouse-ear cress, contains 496 amino acids, is membrane-bound, locates in Cell membrane.

Promotes cell fate progression in stomatal development, In leaves, needed to correctly orient spacing divisions, to limit the number of asymmetric divisions in neighbor cells, and to promote the asymmetric (amplifying) divisions of meristemoids, In stems, promotes the conversion of meristemoids into guard mother cells (GMC) (PubMed:11090210, PubMed:12040198, PubMed:18979118), Positively regulates CAPRICE (CPC) expression in differentiating stomaless-forming cell files (PubMed:19513241), Forms constitutive complexes with ERECTA and ERL1 involved in the recognition of the stomatal regulatory peptides EPF1, EPF2 and EPFL9/STOMAGEN (PubMed:28536146), Modulates the activity of the ligand-receptor pairs EPF2-ERECTA and EPF1-ERL1 in stomatal development (PubMed:16002616, PubMed:22241782), Functions in a combinatorial specific manner with the ERECTA-family (ERf) receptor kinases in the regulation of the immune response (PubMed:27446127)


This is Arogenate dehydratase/prephenate dehydratase 2, chloroplastic protein, from Mouse-ear cress, contains 381 amino acids, is soluble, locates in Plastid.

Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine (PubMed:17726025), Dehydratase that uses arogenate and prephenate as substrates (PubMed:17726025), Utilzes more efficiently arogenate than prephenate (PubMed:17726025), Required for chloroplast division prior to ARC5, but in an ARC3- and ARC6-dependent manner, especially involved in the Z-ring formation (PubMed:30252596)


This is ATP synthase subunit delta, chloroplastic protein, from Mouse-ear cress, contains 234 amino acids, is membrane-bound, locates in Plastid.

This protein is part of the stalk that links CF(0) to CF(1), It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction

Belongs to the ATPase delta chain family


This is Dihydroceramide fatty acyl 2-hydroxylase FAH2 protein, from Mouse-ear cress, contains 237 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Fatty acid 2-hydroxylase involved in the alpha-hydroxylation of the long-chain fatty acid (LCFA) palmitic acid, Probably involved in the resistance response to oxidative stress


This is AFP homolog 2 protein, from Mouse-ear cress, contains 425 amino acids, locates in Nucleus.

Acts as a transcriptional repressor, Negative regulator of jasmonate responses, Connects the JAZ proteins and the non-JAZ protein TIFY8 with the TOPLESS corepressors


This is EPIDERMAL PATTERNING FACTOR-like protein 9 protein, from Mouse-ear cress, contains 102 amino acids, is soluble, locates in Extracellular.

Positively regulates stomatal density and patterning, Acts by competing with EPF2 (AC Q8LC53) for the same receptors, ERECTA (AC Q42371) and TMM (AC Q9SSD1), Not cleaved by the protease CRSP (AC Q9LNU1) (PubMed:25043023)

Belongs to the plant cysteine rich small secretory peptide family, Epidermal patterning factor subfamily


This is Magnesium protoporphyrin IX methyltransferase, chloroplastic protein, from Mouse-ear cress, contains 312 amino acids, is membrane-bound, locates in Plastid.

Converts Mg-protoporphyrin IX to Mg-protoporphyrin IX methylester using S-adenosyl-L-methionine as a cofactor, Involved in chloroplast-to-nucleus signaling by acting as a negative effector of nuclear photosynthetic gene expression

Belongs to the class I-like SAM-binding methyltransferase superfamily, Magnesium protoporphyrin O-methyltransferase family


This is Galactoside 2-alpha-L-fucosyltransferase protein, from Mouse-ear cress, contains 558 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in cell wall biosynthesis, Is both necessary and sufficient for the addition of the terminal fucosyl residue on xyloglucan side chains, but is not involved in the fucosylation of other cell wall components (PubMed:10373113, PubMed:11743104, PubMed:11854459, PubMed:14730072), Associates with other xyloglucan-synthesizing enzymes to form multiprotein complexes for xyloglucan synthesis in the Golgi (PubMed:25392066)

Belongs to the glycosyltransferase 37 family


This is ATP-dependent Clp protease proteolytic subunit 3, chloroplastic protein, from Mouse-ear cress, contains 309 amino acids, is soluble, locates in Plastid.

Cleaves peptides in various proteins in a process that requires ATP hydrolysis, Has a chymotrypsin-like activity, Plays a major role in the degradation of misfolded proteins (By similarity), In the absence of CLPP3, modified ClpPR core(s) could be formed, albeit at strongly reduced levels (PubMed:23548781)


This is Microtubule-associated protein TORTIFOLIA1 protein, from Mouse-ear cress, contains 864 amino acids, is soluble, locates in Cytoplasm.

Plant-specific microtubule-associated protein (MAP) that regulates the orientation of cortical microtubules and the direction of organ growth (PubMed:18577573), Determines microtubule organization by modulating microtubule severing (PubMed:24055158)


This is Parathyroid hormone/parathyroid hormone-related peptide receptor protein, from Dog, contains 595 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for parathyroid hormone and for parathyroid hormone-related peptide, The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system

Belongs to the G-protein coupled receptor 2 family


This is Conodipine-M alpha chain protein, from Magical cone, contains 77 amino acids, is soluble, locates in Extracellular.

Heterodimer: conodipine-M catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, This activity may be supported by the alpha chain, Conodipine-M inhibits the binding of isradipine (a ligand specific for L-type calcium channel) to L-type calcium channels

Belongs to the phospholipase A2 family, Group IX subfamily


This is Excretory canal abnormal protein 6 protein, from Caenorhabditis elegans, contains 843 amino acids, is soluble, locates in Cytoplasm.

Constitutively active protein required for microtubule and F-actin growth, structural maintenance and organization during excretory cell tubulogenesis


This is Defective in cullin neddylation protein 1 protein, from Caenorhabditis elegans, contains 295 amino acids, locates in Nucleus.

Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes, Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity, Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8-charged E2 enzyme to the cullin component of SCF-type complexes


This is Thymine dioxygenase JBP1 protein, from Sauroleishmania tarentolae, contains 827 amino acids, locates in Nucleus.

Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU), DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation, Also specifically binds to base J-containing DNA (J-DNA), Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis, Thymine dioxygenase activity and J-DNA-binding are independent functions

Belongs to the TET family, JBP1 subfamily


This is Nucleomorphin protein, from Social amoeba, contains 756 amino acids, locates in Nucleus.


This is NF-kappa-B inhibitor-like protein 1 protein, from Human, contains 381 amino acids, locates in Nucleus.

Involved in the regulation of innate immune response, Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways, Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli


This is Protein DBF4 homolog A protein, from Human, contains 674 amino acids, has 1 DBF4-type Zinc finger, locates in Nucleus.

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation, Required for progression of S phase, The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle


This is Zinc finger matrin-type protein 5 protein, from Human, contains 170 amino acids, has 1 C3H1-type Zinc finger, locates in Nucleus.


This is Coiled-coil domain-containing protein 39 protein, from Human, contains 941 amino acids, is soluble, locates in Cytoplasm.

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131972), Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity), Not required for outer dynein arm complexes assembly (PubMed:21131972)


This is Signal-transducing adaptor protein 2 protein, from Human, contains 403 amino acids, is soluble, locates in Cytoplasm.

Substrate of protein kinase PTK6, May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity


This is SAP30-binding protein protein, from Human, contains 308 amino acids, locates in Nucleus.

(Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC


This is Krueppel-like factor 15 protein, from Human, contains 416 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

Transcriptional regulator that binds to the GA element of the CLCNKA promoter, Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity), Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis, It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity), Involved in podocyte differentiation (By similarity), Inhibits MYOCD activity, Is a negative regulator of TP53 acetylation, Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is ATPase inhibitor, mitochondrial protein, from Human, contains 106 amino acids, locates in Mitochondrion.

Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix, Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase, Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme


This is DNA helicase MCM8 protein, from Human, contains 840 amino acids, locates in Nucleus.

Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855), Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093), Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855), The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855), However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404), Probably by regulating HR, plays a key role during gametogenesis (By similarity), Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093)


This is F-box only protein 10 protein, from Human, contains 956 amino acids, is soluble, locates in Cytoplasm.

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2, Targets also the receptor for advanced glycation end products RAGE for ubiquitination and subsequent lysosomal degradation (PubMed:28515150), Directly controls HGAL/GCSAM ubiquitination and degradation and thereby decreases BCR signaling (PubMed:31570756)


This is F-box only protein 9 protein, from Human, contains 447 amino acids, is soluble, locates in Cytoplasm.

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability (PubMed:34480022, PubMed:23263282), Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation, In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex, As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1 (PubMed:23263282), Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway (PubMed:34480022), Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (By similarity)


This is Cleavage and polyadenylation specificity factor subunit 3 protein, from Human, contains 684 amino acids, locates in Nucleus.

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition, Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease (PubMed:30507380), Also involved in the histone 3'-end pre-mRNA processing (PubMed:30507380), U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs, Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides, The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site, Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner, Required for entering/progressing through S-phase of the cell cycle (PubMed:30507380), Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity), Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity), Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity)

Belongs to the metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, CPSF3 subfamily


This is E3 ubiquitin-protein ligase AMFR protein, from Human, contains 643 amino acids, has 1 RING-type Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type

E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676), Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410), The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767), In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569), The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569), In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676), Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353), Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408), Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303), Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303), Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327), In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040), Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation (PubMed:36593296)


This is Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 protein, from Human, contains 889 amino acids, is membrane-bound, locates in Cell membrane.

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions, Contributes to the native pacemaker currents in heart (If) and in neurons (Ih), Can also transport ammonium in the distal nephron, Produces a large instantaneous current, Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity)

Belongs to the potassium channel HCN family


This is Short transient receptor potential channel 5 protein, from Human, contains 973 amino acids, is membrane-bound, locates in Cell membrane.

Thought to form a receptor-activated non-selective calcium permeant cation channel, Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors, Has also been shown to be calcium-selective (By similarity), May also be activated by intracellular calcium store depletion, Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity)

Belongs to the transient receptor (TC 1,A,4) family, STrpC subfamily, TRPC5 sub-subfamily


This is Protein-arginine deiminase type-1 protein, from Human, contains 663 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the deimination of arginine residues of proteins

Belongs to the protein arginine deiminase family


This is Zinc finger protein PLAGL1 protein, from Human, contains 463 amino acids, has 7 C2H2-type Zinc finger, locates in Nucleus.

Acts as a transcriptional activator (PubMed:9722527), Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Inhibitor of growth protein 4 protein, from Human, contains 249 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653), Through chromatin acetylation it may function in DNA replication (PubMed:16387653), May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276), Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197), May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197), Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452), Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity)


This is DNA-binding protein SATB2 protein, from Human, contains 733 amino acids, is soluble, locates in Nucleus.

Binds to DNA, at nuclear matrix- or scaffold-associated regions, Thought to recognize the sugar-phosphate structure of double-stranded DNA, Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling, Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers, Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression, Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex, May play an important role in palate formation, Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation


This is Sialidase-3 protein, from Human, contains 428 amino acids, is membrane-bound, locates in Cell membrane.

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides, Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:11298736, PubMed:15847605, PubMed:10861246, PubMed:20511247, PubMed:28646141, PubMed:10405317, PubMed:12011038), Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR (PubMed:17334392, PubMed:25922362), Desialylates EGFR and activates downstream signaling in proliferating cells (PubMed:25922362), Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (PubMed:26251452)

Belongs to the glycosyl hydrolase 33 family


This is Exonuclease 1 protein, from Human, contains 846 amino acids, locates in Nucleus.

5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity, Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch, Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment, Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes, Essential for male and female meiosis

Belongs to the XPG/RAD2 endonuclease family, EXO1 subfamily


This is Cell cycle protein kinase spo4 protein, from Fission yeast, contains 429 amino acids, locates in Nucleus.

Required for the initiation of meiosis II and progression through anaphase II

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CDC7 subfamily


This is Versatile peroxidase VPL1 protein, from Boletus of the steppes, contains 361 amino acids, is soluble, locates in Extracellular.

A versatile ligninolytic peroxidase that combines the substrate specificity characteristics of the two other ligninolytic peroxidases, manganese peroxidase and lignin peroxidase

Belongs to the peroxidase family, Ligninase subfamily


This is CENP-A multicopy suppressor protein 2 protein, from Fission yeast, contains 697 amino acids, has 1 GATA-type; atypical Zinc finger, locates in Nucleus.

GATA-type; atypical

Required for proper chromosome segregation via regulation of CENP-A localization to the centromere


This is Glucosidase 2 subunit beta protein, from Fission yeast, contains 506 amino acids, locates in Endoplasmic reticulum.

Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins in the endoplasmic reticulum (ER), Specifically required for the cleavage of the final glucose, The subunit beta retains the catalytic subunit alpha in the ER


This is Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial protein, from Fission yeast, contains 379 amino acids, locates in Mitochondrion.

Performs an essential role in the oxidative function of the citric acid cycle and is involved in glutamate biosynthesis (PubMed:7903653), Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs (PubMed:10975257)

Belongs to the isocitrate and isopropylmalate dehydrogenases family


This is Guanosine-diphosphatase protein, from Fission yeast, contains 556 amino acids, is membrane-bound, locates in Golgi apparatus.

After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol


This is J-type co-chaperone jac1, mitochondrial protein, from Fission yeast, contains 225 amino acids, is soluble, locates in Mitochondrion.

Co-chaperone required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria (PubMed:26545917), Stimulates the ATPase activity of the mitochondrial Hsp70 chaperone ssc1, to mediate the transfer of iron-sulfur clusters from isu1 to grx5 (PubMed:26545917)


This is Polynucleotide 5'-hydroxyl-kinase grc3 protein, from Fission yeast, contains 736 amino acids, locates in Nucleus.

Polynucleotide 5'-kinase required for both rRNA processing and heterochromatic gene silencing

Belongs to the Clp1 family, NOL9/GRC3 subfamily


This is Protein will die slowly protein, from Fruit fly, contains 361 amino acids, locates in Nucleus.

Contributes to histone modification, May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:25310983), In neurons and together with DNA N6-methyl adenine demethylase Tet, plays a role in the maintenance of transcriptional activation for specific sets of genes (PubMed:30078725)

Belongs to the WD repeat WDR5/wds family


This is UbiA prenyltransferase domain-containing protein 1 homolog protein, from Fruit fly, contains 359 amino acids, is membrane-bound, locates in Mitochondrion.

Prenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform, thereby acting as a mitochondrial electron carrier, Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4, MK-4 acts as a membrane electron carrier downstream of a electron transport chain complex, improving mitochondrial oxygen consumption

Belongs to the UbiA prenyltransferase family


This is Kinetochore protein Spc25 protein, from Fruit fly, contains 222 amino acids, locates in Nucleus.

Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis (PubMed:17895365, PubMed:17333235), Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:17895365, PubMed:17333235), Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics (PubMed:17333235), The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (By similarity)


This is DNA replication licensing factor Mcm6 protein, from Fruit fly, contains 817 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity Required for DNA replication and cell proliferation, Required for mitotic cycles, endocycles, and the special S phase associated with the amplification of chorion genes; has a role in origin unwinding or fork elongation at chorion loci


This is Histone chaperone asf1 protein, from Fruit fly, contains 218 amino acids, locates in Nucleus.

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10591219, PubMed:12381660, PubMed:14561777, PubMed:16151251, PubMed:16396992), Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11533245), Plays a role in the formation of silent heterochromatin (PubMed:12381660, PubMed:28320872)


This is Longitudinals lacking protein, isoforms J/P/Q/S/Z protein, from Fruit fly, contains 963 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems, Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo


This is Proteasome inhibitor PI31 subunit protein, from Fruit fly, contains 270 amino acids, is soluble, locates in Cytoplasm.

Plays an important role in the control of proteasome function, Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome, Enhances 26S proteasome function by promoting its assembly through the interaction with the assembly chaperones PSMD9 and PMSD5, Functions together with ntc to control non-apoptotic caspase activation during sperm individualization, In testis, is required for proper protein degradation and germline cell cycle progression

Belongs to the proteasome inhibitor PI31 family


This is U3 small nucleolar RNA-associated protein 18 homolog protein, from Fruit fly, contains 506 amino acids, locates in Nucleus.

Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA, Regulation of cell size by ribosome synthesis is an important parameter for stem cell maintenance and function


This is Spindle assembly abnormal protein 6 homolog protein, from Fruit fly, contains 472 amino acids, is soluble, locates in Cytoplasm.

Central scaffolding component of the centrioles ensuring their 9-fold symmetry (PubMed:17412918, PubMed:17463247, PubMed:30013109), Required for centrosome biogenesis and duplication (PubMed:17412918, PubMed:17463247, PubMed:30013109, PubMed:33704067), In ciliated neurons, required for centriole assembly but not necessary for cilium basal body and cilia function (PubMed:30013109), Required for sperm cilium basal body elongation together with Cep135 and Ana2 (PubMed:30013109)


This is Protein distal antenna-related protein, from Fruit fly, contains 419 amino acids, locates in Nucleus.

Probable transcription factor with a role in the retinal determination (RD) network, Regulates ato expression and is required for normal R8 induction and differentiation, Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF), Dan and Danr lie downstream of so and require dac function for highest levels of expression, Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures


This is Phagocyte signaling-impaired protein protein, from Fruit fly, contains 948 amino acids, locates in Lysosome/Vacuole.

Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of proteins beginning with Met-Asp or Met-Glu (By similarity), Has 2 roles in the larval immune response: required both for the phagocytic degradation of internalized bacteria and for the induction of Defensin in the fat body, Within the phagocytic blood cells, has a role in detection of infection and activation of the humoral immune response


This is Twinfilin protein, from Fruit fly, contains 343 amino acids, is soluble, locates in Cytoplasm.

Actin-binding protein involved in motile and morphological processes, Inhibits actin polymerization, likely by sequestering G-actin

Belongs to the actin-binding proteins ADF family, Twinfilin subfamily


This is Protein roadkill protein, from Fruit fly, contains 829 amino acids, locates in Nucleus.

Involved in segment polarity, In complex with gft/CUL3, promotes ubiquitination of ci and its subsequent degradation by the proteasome, which results in hh signaling attenuation, This regulation may be important during eye formation for proper packing of ommatidia into a hexagonal array


This is Leishmanolysin-like peptidase protein, from Fruit fly, contains 683 amino acids, is soluble, locates in Cytoplasm.

Essential for the coordination of mitotic progression, and also plays a role in cell migration


This is Protein valois protein, from Fruit fly, contains 367 amino acids, is soluble, locates in Cytoplasm.

Involved in specific localization of cytoplasmic proteins during the formation of pole plasm, Required for synthesis and/or stability of oskar protein (osk) and localization of tudor (tud) in both the nuage and posterior pole of the oocyte, Required for normal posterior localization of osk in later stages of oogenesis and for posterior localization of the vasa (vas) protein during the entire process of pole plasm assembly, May act by regulating the complex that contains the arginine N-methyltransferase csul


This is Angiotensin-converting enzyme-related protein protein, from Fruit fly, contains 630 amino acids, is soluble, locates in Extracellular.

May be involved in the specific maturation or degradation of a number of bioactive peptides, May have a role in the specification of heart progenitors


This is Putative apoptosis-inducing factor 1, mitochondrial protein, from Fruit fly, contains 739 amino acids, is soluble, locates in Mitochondrion.

Probable NADH oxidoreductase (By similarity), Mitochondrial effector of cell death that plays roles in developmentally regulated cell death and normal mitochondrial function

Belongs to the FAD-dependent oxidoreductase family


This is Eukaryotic translation initiation factor 4E-binding protein Mextli protein, from Fruit fly, contains 653 amino acids, is soluble, locates in Cytoplasm.


This is Protein melted protein, from Fruit fly, contains 994 amino acids, is membrane-bound, locates in Cell membrane.

Participates in fat metabolism regulation by recruiting FOXO and the TSC1-TSC2 complex to the cell membrane, which positively regulates TOR activity and negatively regulates the expression of FOXO target genes, Involved in R8 photoreceptor subtype specification, During early embryonic development, may be required for ectodermal patterning


This is Ubiquitin-conjugating enzyme E2 C protein, from Fruit fly, contains 178 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the covalent attachment of ubiquitin to other proteins, Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis, Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit

Belongs to the ubiquitin-conjugating enzyme family


This is Protein bric-a-brac 1 protein, from Fruit fly, contains 977 amino acids, locates in Nucleus.

Probably acts as a transcriptional regulator, Required for the specification of the tarsal segment, Also involved in antenna development


This is Protein windpipe protein, from Fruit fly, contains 677 amino acids, is membrane-bound, locates in Cell membrane.

Plays a role in negative regulation of the JAK/STAT pathway by binding to the receptor dome and promoting its internalization for subsequent lysosomal degradation, thereby reducing JAK/STAT signaling


This is Solute carrier family 22 member 21 protein, from Mouse, contains 564 amino acids, is membrane-bound, locates in Peroxisome.

Sodium-ion independent, medium affinity carnitine transporter, Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium, Relative uptake activity ratio of carnitine to TEA is 746

Belongs to the major facilitator (TC 2,A,1) superfamily, Organic cation transporter (TC 2,A,1,19) family


This is Chloride channel protein ClC-Kb protein, from Mouse, contains 687 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-gated chloride channel, Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport, May be important in urinary concentrating mechanisms, May be the basolateral chloride channel mediating net chloride absorption in CTAL cells

Belongs to the chloride channel (TC 2,A,49) family, CLCNKB subfamily


This is Homeobox protein MIXL1 protein, from Mouse, contains 231 amino acids, locates in Nucleus.

Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation, Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages, Also involved in the morphogenesis of the heart and the gut during embryogenesis, Acts as a negative regulator of brachyury expression


This is Receptor activity-modifying protein 3 protein, from Mouse, contains 147 amino acids, is membrane-bound, locates in Cell membrane.

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner, Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane, Acts as a receptor for adrenomedullin (AM) together with CALCRL


This is GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase protein, from Mouse-ear cress, contains 463 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for N-linked oligosaccharide assembly, Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum

Belongs to the glycosyltransferase 4 family


This is Protein CLAVATA 3 protein, from Mouse-ear cress, contains 96 amino acids, is soluble, locates in Extracellular.

The secreted peptide MCLV3 activates a signal transduction cascade to restrict WUSCHEL (WUS) expression, inducing shoot and root meristem consumption as cells differentiated into other organs

Belongs to the CLV3/ESR signal peptide family


This is Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase protein, from Mouse-ear cress, contains 444 amino acids, is membrane-bound, locates in Golgi apparatus.

Initiates complex N-linked carbohydrate formation, Essential for the conversion of high-mannose to hybrid and complex N-glycans, Required for normal root growth and morphology

Belongs to the glycosyltransferase 13 family


This is [Fructose-bisphosphate aldolase]-lysine N-methyltransferase, chloroplastic protein, from Mouse-ear cress, contains 482 amino acids, is soluble, locates in Plastid.

Protein-lysine methyltransferase methylating chloroplastic fructose 1,6-bisphosphate aldolases, Can also use with low efficiency gamma-tocopherol methyltransferase as substrate, but not a cytosolic aldolase, Able to interact with unmethylated Rubisco, but unlike in pea, the complex is catalytically unproductive

Belongs to the class V-like SAM-binding methyltransferase superfamily, Plant protein-lysine LSMT methyltransferase family


This is Probable WRKY transcription factor 4 protein, from Mouse-ear cress, contains 514 amino acids, locates in Nucleus.

Transcription factor that binds specifically to the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element, Has a positive role in resistance to necrotrophic pathogens (e,g, Botrytis cinerea), but a negative effect on plant resistance to biotrophic pathogens (e,g, Pseudomonas syringae)


This is Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 protein, from Caenorhabditis elegans, contains 817 amino acids, is soluble, locates in Cytoplasm.

Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis (PubMed:16289132, PubMed:16338136, PubMed:17869113, PubMed:18854162, PubMed:18199581, PubMed:19879842), Through phosphorylation of P granule components including meg-1, promotes the disassembly of zygotic P granules in the anterior cytoplasm during zygote polarization, and thus plays a role in P granule distribution and segregation in early stage embryos following meiosis (PubMed:25535836), Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos (PubMed:14697358), Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage (PubMed:18199581)

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily


This is Myosin-K heavy chain protein, from Social amoeba, contains 858 amino acids, is soluble, locates in Cytoplasm.

Myosins are actin-based motor molecules with ATPase activity, Involved in phagocytosis and motility, and in the maintenance and dynamics of cell cortex

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily, Myosin family


This is Activating transcription factor 3 protein, from Fruit fly, contains 613 amino acids, locates in Nucleus.

Transcription factor which binds to the cAMP response element (CRE) (PubMed:20023169), Regulates metabolic and innate immune homeostasis, possibly by controlling appropriate expression of genes involved in peritrophic matrix composition and ensuring the normal digestive and immune function of the gut (PubMed:22851689), Required for the expression of odorant receptors Or43b and Or47b (PubMed:26848073)

Belongs to the bZIP family, ATF subfamily


This is Polypeptide N-acetylgalactosaminyltransferase 3 protein, from Fruit fly, contains 667 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:12829714), It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties, Prefers EA2 as substrate, Has weak activity toward Muc5AC-3, -13 and -3/13 substrates (PubMed:12829714), Plays a critical role in the regulation of integrin-mediated cell adhesion during wing development by influencing, via glycosylation, the secretion and localization of the integrin ligand Tig to the basal cell layer interface (PubMed:18835818, PubMed:20371600, PubMed:20807760, PubMed:22157008), Might have a role in protein O-glycosylation in the Golgi and thereby in establishing and/or maintaining a proper secretory apparatus structure (PubMed:20807760), Together with Pgant35A, regulates integrin levels and activity-dependent integrin signaling at the synapse in neurons and muscles (PubMed:25253852)

Belongs to the glycosyltransferase 2 family, GalNAc-T subfamily


This is Myotubularin-related protein 7 protein, from Human, contains 660 amino acids, is soluble, locates in Cytoplasm.

Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2)

Belongs to the protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily


This is HIG1 domain family member 1A, mitochondrial protein, from Human, contains 93 amino acids, is membrane-bound, locates in Mitochondrion.

Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water, May play a role in the assembly of respiratory supercomplexes


This is Histone chaperone ASF1A protein, from Human, contains 204 amino acids, locates in Nucleus.

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524), Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198), Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807), Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485), Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527)


This is Protein-arginine deiminase type-2 protein, from Human, contains 665 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the deimination of arginine residues of proteins

Belongs to the protein arginine deiminase family


This is Zinc finger and BTB domain-containing protein 1 protein, from Human, contains 713 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 UBZ-type Zinc finger, has 5 C2H2-type Zinc finger, is soluble, locates in Nucleus.

C2H2-type 1; atypical

C2H2-type 2; atypical

UBZ-type

Acts as a transcriptional repressor (PubMed:20797634), Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167), In addition, has a role in translesion DNA synthesis, Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165), Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity)


This is Protein SSUH2 homolog protein, from Human, contains 375 amino acids, is soluble, locates in Cytoplasm.


This is Cytochrome c oxidase assembly factor 3 homolog, mitochondrial protein, from Human, contains 106 amino acids, is membrane-bound, locates in Mitochondrion.

Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly, MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion, Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly


This is Thyroid hormone receptor-associated protein 3 protein, from Human, contains 955 amino acids, is soluble, locates in Nucleus.

Involved in pre-mRNA splicing, Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC), Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition, May be involved in nuclear mRNA decay, Involved in regulation of signal-induced alternative splicing, During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells, Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA, Involved in response to DNA damage, Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex, Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit, Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand, May play a role in the terminal stage of adipocyte differentiation, Plays a role in the positive regulation of the circadian clock, Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798)


This is ARF GTPase-activating protein GIT1 protein, from Human, contains 761 amino acids, has 1 C4-type Zinc finger, is soluble, locates in Cytoplasm.

GTPase-activating protein for ADP ribosylation factor family members, including ARF1, Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity), Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601), Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400), May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197), May act as scaffold for MAPK1/3 signal transduction in focal adhesions, Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189), Plays a role in brain development and function, Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity), Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193), In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane, These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502), May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity), In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity), In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783), May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity), Required for successful bone regeneration during fracture healing (By similarity), The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity), May play a role in angiogenesis during fracture healing (By similarity), In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302), Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721)


This is Zinc finger and BTB domain-containing protein 32 protein, from Human, contains 487 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence, May function as a transcriptional transactivator and transcriptional repressor, Probably exerts its repressor effect by preventing GATA3 from binding to DNA, May play a role in regulating the differentiation and activation of helper T-cells (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Tyrosine--tRNA ligase, mitochondrial protein, from Human, contains 477 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)

Belongs to the class-I aminoacyl-tRNA synthetase family


This is Signaling threshold-regulating transmembrane adapter 1 protein, from Human, contains 196 amino acids, is membrane-bound, locates in Cell membrane.

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells, Involved in positive selection of T-cells


This is E3 ubiquitin-protein ligase ARIH1 protein, from Human, contains 557 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger, is soluble, locates in Cytoplasm.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686), Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346), The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346), E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346), Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349), According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349), According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119), Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916), In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology (PubMed:29689197)

Belongs to the RBR family, Ariadne subfamily


This is U3 small nucleolar RNA-associated protein 18 homolog protein, from Human, contains 556 amino acids, locates in Nucleus.

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome, Involved in nucleolar processing of pre-18S ribosomal RNA


This is Mitochondrial import inner membrane translocase subunit Tim10 B protein, from Human, contains 103 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane, The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force, In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space


This is Insulin-induced gene 2 protein protein, from Human, contains 225 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062), Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062), Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:26160948, PubMed:17428920, PubMed:32322062), In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:32322062), Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062), Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 (PubMed:16606821, PubMed:22143767)


This is Lipid droplet-regulating VLDL assembly factor AUP1 protein, from Human, contains 410 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

(Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles


This is Solute carrier family 22 member 7 protein, from Human, contains 548 amino acids, is membrane-bound, locates in Cell membrane.

Mediates sodium-independent multispecific organic anion transport, Transport of prostaglandin E2, prostaglandin F2-alpha, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate


This is Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 protein, from Human, contains 151 amino acids, locates in Nucleus.

Transcription factor, Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788)


This is TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L protein, from Human, contains 622 amino acids, locates in Nucleus.

Functions as a component of the PCAF complex, The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context, The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable), With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming, Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state, Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity)


This is Small ribosomal subunit protein uS2A protein, from Fission yeast, contains 292 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity), uS2 is required for the assembly and/or stability of the 40S ribosomal subunit, Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (PubMed:14623272)

Belongs to the universal ribosomal protein uS2 family


This is Histone-lysine N-methyltransferase, H3 lysine-37 specific protein, from Fission yeast, contains 147 amino acids, is soluble, locates in Cytoplasm.

Histone lysine methyltransferase that specifically mono-, di-, and trimethylates 'Lys-37' of histone H3 to regulate sporulation

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is 1,3-beta-glucanosyltransferase gas4 protein, from Fission yeast, contains 456 amino acids, is membrane-bound, locates in Cell membrane.

Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall, Involved in spore wall assembly

Belongs to the glycosyl hydrolase 72 family


This is Deleted in azoospermia-like protein, from Zebrafish, contains 229 amino acids, is soluble, locates in Cytoplasm.

RNA-binding protein involved in gametogenesis in both males and females (PubMed:12296827), Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts (PubMed:12296827), Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable), Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity)


This is Organic cation/carnitine transporter 2 protein, from Mouse, contains 557 amino acids, is membrane-bound, locates in Cell membrane.

Sodium-ion dependent, high affinity carnitine transporter, Involved in the active cellular uptake of carnitine, Transports one sodium ion with one molecule of carnitine (PubMed:10454528, PubMed:20722056), Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium, Also relative uptake activity ratio of carnitine to TEA is 11,3 (PubMed:10454528), May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity)

Belongs to the major facilitator (TC 2,A,1) superfamily, Organic cation transporter (TC 2,A,1,19) family


This is WAS/WASL-interacting protein family member 3 protein, from Rat, contains 485 amino acids, is soluble, locates in Cytoplasm.

May have a role in spermatogenesis (By similarity), May be a regulator of cytoskeletal organization


This is Seipin protein, from Mouse, contains 383 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity),In association with LDAF1, defines the sites of LD formation in the ER (By similarity), Also required for growth and maturation of small nascent LDs into larger mature LDs (By similarity), Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs (By similarity), Regulates the maturation of ZFYVE1-positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts (By similarity), Binds anionic phospholipids including phosphatidic acid (By similarity), Plays an important role in the differentiation and development of adipocytes (PubMed:18458148, PubMed:19574402, PubMed:21551454, PubMed:22269949)


This is Dolichol phosphate-mannose biosynthesis regulatory protein protein, from Rat, contains 84 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Regulates the biosynthesis of dolichol phosphate-mannose (PubMed:9724629), Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1 (PubMed:9724629), Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis, May act by regulating the GPI-GNT complex (By similarity)


This is Actin-depolymerizing factor 4 protein, from Mouse-ear cress, contains 139 amino acids, is soluble, locates in Cytoplasm.

Actin-depolymerizing protein, Severs actin filaments (F-actin) and binds to actin monomers (PubMed:19346440, PubMed:22010035), Contributes to the stochastic dynamic turnover of actin filaments (PubMed:22010035), Binds monomeric actin (G-actin) with a marked preference for the ADP-loaded form and inhibits the rate of nucleotide exchange on G-actin, Involved in resistance triggered by the effector AvrPphB of Pseudomonas syringae pv tomato (Pst), May modulate the AvrPphB-RPS5-mediated defense signal transduction pathway (PubMed:19346440), During AvrPphB-triggered resistance signaling pathway, involved in the control of MPK3 and MPK6 activation, via the coordinated regulation of actin cytoskeletal dynamics and RPS5 resistance gene transcription (PubMed:23144618), During innate immune response triggered by the bacterial elf26 peptide, the inhibition of ADF4 regulates actin dynamics in order to execute key events associated with pattern-triggered immunity (PTI), such as cell wall fortification and transcriptional activation of defense gene markers (PubMed:24464292)

Belongs to the actin-binding proteins ADF family


This is tRNA dimethylallyltransferase 2 protein, from Mouse-ear cress, contains 466 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A), Involved in the cis-type cytokinin biosynthesis


This is Arogenate dehydratase 3, chloroplastic protein, from Mouse-ear cress, contains 424 amino acids, is soluble, locates in Plastid.

Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine (PubMed:17726025), Together with GCR1 and GPA1, required for blue light-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings (PubMed:16415218)


This is Homeobox-leucine zipper protein HDG3 protein, from Mouse-ear cress, contains 725 amino acids, locates in Nucleus.

Probable transcription factor (By similarity), Seems to promote cell differentiation (PubMed:25564655)

Belongs to the HD-ZIP homeobox family, Class IV subfamily


This is Transcription elongation factor TFIIS protein, from Mouse-ear cress, contains 378 amino acids, has 1 TFIIS-type Zinc finger, locates in Nucleus.

TFIIS-type

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites (Probable), Involved in the control of seed dormancy and germination (PubMed:19150360, PubMed:21799800)


This is Zinc finger protein MAGPIE protein, from Mouse-ear cress, contains 506 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger, locates in Nucleus.

C2H2-type 2; degenerate

CCHC-type 2; atypical

Transcription factor that regulates tissue boundaries and asymmetric cell division (PubMed:17785527, PubMed:25829440), Contributes to the sequestration of 'SHORT-ROOT' to the nucleus (PubMed:17785527, PubMed:25829440), Interacts with the SCR and MGP promoters (PubMed:21935722), Does not show transcription activity by itself, but regulates the transcription of downstream genes through interaction with other transcription factors (PubMed:21935722), Binds DNA via its zinc fingers (PubMed:24821766), Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766), Positively involved in gibberellic acid (GA) signaling (PubMed:24821766)


This is Lipase A protein, from Pseudozyma aphidis, contains 462 amino acids, is soluble, locates in Extracellular.

Hydrolyzes triglycerides, with a preference for substrates with short-chain lengths (C4 to C8), Has the highest activity with tributyrin (C4), followed by tricaproin (C6) and tricaprylin (C8), Can also hydrolyze vinylacetate (C2) and triolein (C18), but with lower efficiency, Has no activity with tripalmitin (C16)

Belongs to the AB hydrolase superfamily, Lipase family


This is Transcription factor TCP12 protein, from Mouse-ear cress, contains 356 amino acids, locates in Nucleus.

Transcription factor that prevents axillary bud outgrowth, May also delay early axillary bud development, Probably involved in the auxin-induced control of apical dominance


This is Fat storage-inducing transmembrane protein 1 protein, from Human, contains 292 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:18160536) (By similarity), Directly binds to diacylglycerol (DAGs) and triacylglycerol (By similarity)

Belongs to the FIT family, FIT1 subfamily


This is Dynein regulatory complex subunit 3 protein, from Chlamydomonas smithii, contains 524 amino acids, is soluble, locates in Cytoplasm.

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (PubMed:23427265, PubMed:25411337), Required for normal flagellar waveform (PubMed:26063732)


This is MD-2-related lipid-recognition protein protein, from Tobacco hawkmoth, contains 151 amino acids, is soluble, locates in Extracellular.

Binds to lipopolysaccharide from a variety of Gram-negative bacteria and to lipid A


This is Complement C1q and tumor necrosis factor-related protein 9B protein, from Human, contains 333 amino acids, is soluble, locates in Extracellular.

Probable adipokine, Activates AMPK, AKT, and p44/42 MAPK signaling pathways


This is Omega-theraphotoxin-Bs2a protein, from Mexican red knee tarantula, contains 99 amino acids, is soluble, locates in Extracellular.

Has minor, but significant effects on the Para/tipE insect sodium channel

Belongs to the neurotoxin 14 (magi-1) family, 08 (Ltx-4) subfamily


This is Brevinin-1CDYa protein, from Dybovsky's frog, contains 67 amino acids, is soluble, locates in Extracellular.

Antimicrobial peptide, Has low activity against the Gram-positive bacterium S,aureus (MIC=12,5 uM) and the Gram-negative bacterium E,coli (MIC=25 uM), Has weak hemolytic activity against human erythrocytes

Belongs to the frog skin active peptide (FSAP) family, Brevinin subfamily


This is Peptide deformylase 1A, chloroplastic protein, from Rice, contains 260 amino acids, is soluble, locates in Plastid.

Removes the formyl group from the N-terminal Met of newly synthesized proteins

Belongs to the polypeptide deformylase family


This is Centrosomal protein of 63 kDa-A protein, from African clawed frog, contains 649 amino acids, is soluble, locates in Cytoplasm.

Required for normal spindle assembly (PubMed:19182792), Plays a key role in mother-centriole-dependent centriole duplication (PubMed:19182792), Plays a role in DNA damage response (PubMed:19182792), Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:19182792)


This is Low-redox potential peroxidase protein, from Poroid brown-rot fungus, contains 330 amino acids, is soluble, locates in Extracellular.

Can oxidize the lignin redox mediator veratryl alcohol to veratryl aldehyde, May be involved in oxidation of lignocellulose substrates

Belongs to the peroxidase family, Ligninase subfamily


This is Sauvatide protein, from Sauvage's leaf frog, contains 62 amino acids, is soluble, locates in Extracellular.

Induces contraction of smooth muscle in isolated rat urinary bladder with an EC(50) value of 2,2nM

Belongs to the frog skin active peptide (FSAP) family


This is Extracellular metalloprotease 1 protein, from Valley fever fungus, contains 276 amino acids, is soluble, locates in Extracellular.

Secreted metalloproteinase that allows assimilation of proteinaceous substrates, Pays a pivotal role as a pathogenicity determinant during infections and contributes to the ability of the pathogen to persist within the mammalian host, Digests an immunodominant cell surface antigen (SOWgp) and prevents host recognition of endospores during the phase of development when these fungal cells are most vulnerable to phagocytic cell defenses


This is Sporulation-specific protein 13 protein, from Fission yeast, contains 138 amino acids, is soluble, locates in Cytoplasm.

Involved in sporulation, Plays a significant role in modification of the spindle pole body prior to spore formation and is required for initiating forespore membrane formation


This is Glucan endo-1,3-beta-D-glucosidase ARB_01444 protein, from Trichophyton mentagrophytes, contains 909 amino acids, is soluble, locates in Extracellular.

Cleaves internal linkages in 1,3-beta-glucan (By similarity), Probably involved in cell separation after cytokinesis (By similarity)

Belongs to the glycosyl hydrolase 81 family


This is Poly-cysteine and histidine-tailed protein protein, from Trichina worm, contains 424 amino acids, is soluble, locates in Extracellular.


This is 4-O-methyl-glucuronoyl methylesterase protein, from Split gill fungus, contains 393 amino acids, is soluble, locates in Extracellular.

Glucuronoyl esterase which may play a significant role in biomass degradation, as it is considered to disconnect hemicellulose from lignin through the hydrolysis of the ester bond between 4-O-methyl-D-glucuronic acid residues of glucuronoxylans and aromatic alcohols of lignin

Belongs to the carbohydrate esterase 15 (CE15) family


This is Temporin-HN1 protein, from Odor frog, contains 62 amino acids, is soluble, locates in Extracellular.

Has antimicrobial activity against some Gram-positive bacteria and fungi but has no activity against a range of Gram-negative bacteria except P,faecalis, Active against the Gram-positive bacteria S,aureus ATCC 25923 (MIC=37,5 uM), S,carnosus KHS (MIC=37,5 uM), B,licheniformis X39 (MIC=19 uM), R,rhodochrous X15 (MIC=4,8 uM), is virtually inactive against E,faecalis 981 (MIC=150 uM) and inactive against E,faecium 091299, Has some antimicrobial activity against the Gram-negative bacterium P,faecalis X29 (MIC=75 uM) and is inactive against E,coli, P,aeruginosa and S,typhi, Has antifungal activity against C,albicans ATCC 2002 (MIC=19 uM) and lower activity against the slime mold 090223 (MIC=75 uM), Has low hemolytic activity against human erythrocytes (LC(50)=75 uM)

Belongs to the frog skin active peptide (FSAP) family, Temporin subfamily


This is Temporin-HN2 protein, from Odor frog, contains 59 amino acids, is soluble, locates in Extracellular.

Has antimicrobial activity against some Gram-positive bacteria and fungi but has no activity against a range of Gram-negative bacteria except P,faecalis, Active against the Gram-positive bacteria S,aureus ATCC 25923 (MIC=4,8 uM), S,carnosus KHS (MIC=19 uM), B,licheniformis X39 (MIC=19 uM) and R,rhodochrous X15 (MIC=2,4 uM) but is inactive against E,faecium 091299 and E,faecalis 981, Has a less potent antimicrobial activity against the Gram-negative bacterium P,faecalis X29 (MIC=37,5 uM) and is inactive against E,coli, P,aeruginosa and S,typhi, Has antifungal activity against C,albicans ATCC 2002 (MIC=9,5 uM) and is also active against the slime mold 090223 (MIC=9,5 uM), Has extremely low hemolytic activity against human erythrocytes (LC(50)=300 uM)


This is Netrin receptor UNC5D protein, from Rat, contains 956 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Ig-like C2-type

Receptor for the netrin NTN4 that promotes neuronal cell survival, Plays a role in cell-cell adhesion and cell guidance, Receptor for netrin involved in cell migration, Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding, May play a role in apoptosis in response to DNA damage, It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity), Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity)


This is External alternative NADH-ubiquinone oxidoreductase, mitochondrial protein, from Yeast, contains 582 amino acids, is membrane-bound, locates in Mitochondrion.

Alternative NADH-ubiquinone oxidoreductase which catalyzes the oxidation of mitochondrial NADH does not translocate protons across the inner mitochondrial membrane

Belongs to the NADH dehydrogenase family


This is TORTIFOLIA1-like protein 1 protein, from Mouse-ear cress, contains 821 amino acids, is soluble, locates in Cytoplasm.

Plant-specific microtubule-associated protein (MAP) that regulates the orientation of cortical microtubules and the direction of organ growth


This is Vacuole membrane protein KMS2 protein, from Mouse-ear cress, contains 416 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the early secretory pathway, Required for the correct export of secretory products from the endoplasmic reticulum (ER) and involved in the maintenance of ER integrity


This is Sucrose synthase 5 protein, from Mouse-ear cress, contains 836 amino acids, is soluble, locates in Extracellular.

Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways, Functions in callose synthesis at the site of phloem sieve elements

Belongs to the glycosyltransferase 1 family, Plant sucrose synthase subfamily


This is Xyloglucan galactosyltransferase XLT2 protein, from Mouse-ear cress, contains 517 amino acids, is membrane-bound, locates in Golgi apparatus.

Functions in xyloglucan synthesis by adding side chains to the xylosylated glucan backbone, Involved in galactosylating hemicellulose xyloglucan (XyG) at the second position of the XXXG motif to form XLXG (PubMed:22474179), Associates with other xyloglucan-synthesizing enzymes to form multiprotein complexes for xyloglucan synthesis in the Golgi (PubMed:25392066)

Belongs to the glycosyltransferase 47 family


This is Beta-mannosidase B protein, from Myceliophthora thermophila, contains 855 amino acids, is soluble, locates in Extracellular.

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length, Prefers mannobiose over mannotriose, Is also severely restricted by galactosyl substitutions at the +1 subsite (By similarity), Has no activity against polymeric mannan

Belongs to the glycosyl hydrolase 2 family, Beta-mannosidase B subfamily


This is Tachykinin-like peptide protein, from Kwangsi warty tree frog, contains 91 amino acids, is soluble, locates in Extracellular.

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles, In vitro, induces contraction of guinea pig ileum smooth muscle in a dose-dependent manner


This is LIM domain-containing protein WLIM2a protein, from Mouse-ear cress, contains 200 amino acids, is soluble, locates in Cytoplasm.

Binds to actin filaments and promotes cross-linking into thick bundles, Has an actin-stabilizing activity, The actin regulatory activities are not regulated by pH and [Ca(2+)]


This is Nematode resistance protein-like HSPRO2 protein, from Mouse-ear cress, contains 435 amino acids, is soluble, locates in Cytoplasm.


This is Thylakoidal processing peptidase 1, chloroplastic protein, from Mouse-ear cress, contains 340 amino acids, is membrane-bound, locates in Plastid.

Cleaves the thylakoid-transfer domain from a chloroplast protein


This is Transforming growth factor-beta-induced protein ig-h3 protein, from Pig, contains 683 amino acids, is soluble, locates in Extracellular.

Plays a role in cell adhesion (By similarity), May play a role in cell-collagen interactions (PubMed:9061001)


This is Transcription initiation factor TFIID subunit 7 protein, from Fission yeast, contains 393 amino acids, locates in Nucleus.

TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription, Also involved in the transport of mRNA from the nucleus to the cytoplasm