This is Membrane protein of ER body 1 protein, from Mouse-ear cress, contains 611 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May sequester excess cytosolic iron and manganese into endoplasmic reticulum to reduce metal ion toxicity, Not essential for the accumulation of ER body components, including PYK10


This is Calcitonin gene-related peptide type 1 receptor protein, from Pig, contains 462 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3, The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity)

Belongs to the G-protein coupled receptor 2 family


This is Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1 protein, from Caenorhabditis elegans, contains 882 amino acids, locates in Nucleus.

Possible role in the function of olfactory neurons

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily


This is Splicing factor Cactin protein, from Human, contains 758 amino acids, locates in Nucleus.

Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (PubMed:28062851), Required for the splicing of CDCA5/Sororin, a regulator of sister chromatid cohesion (PubMed:28062851), Involved in the regulation of innate immune response (PubMed:20829348), Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (PubMed:20829348, PubMed:26363554), Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (PubMed:20829348, PubMed:26363554)


This is GATA zinc finger domain-containing protein 1 protein, from Human, contains 269 amino acids, has 1 GATA-type Zinc finger, locates in Nucleus.

GATA-type

Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3)


This is Non-structural maintenance of chromosomes element 1 homolog protein, from Human, contains 266 amino acids, has 1 RING-type; atypical Zinc finger, locates in Nucleus.

RING-type; atypical

RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate, Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex, Involved in maintenance of genome integrity, DNA damage response and DNA repair (PubMed:29225034, PubMed:20864041), NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair (PubMed:18086888), MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery, Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors (PubMed:29225034)


This is Fatty acyl-CoA reductase 1 protein, from Human, contains 515 amino acids, is membrane-bound, locates in Peroxisome.

Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123), It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (PubMed:20071337, PubMed:24108123, PubMed:33239752), In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity)

Belongs to the fatty acyl-CoA reductase family


This is PEST proteolytic signal-containing nuclear protein protein, from Human, contains 178 amino acids, locates in Nucleus.

May be involved in cell cycle regulation


This is E3 ubiquitin-protein ligase ZNRF4 protein, from Human, contains 429 amino acids, has 1 RING-type; atypical Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 (PubMed:28656966), Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830), Could have a role in spermatogenesis (By similarity)


This is Inactive heparanase-2 protein, from Human, contains 592 amino acids, is soluble, locates in Extracellular.

Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity, Inhibits HPSE, possibly by competing for its substrates (in vitro)

Belongs to the glycosyl hydrolase 79 family


This is Oncoprotein-induced transcript 3 protein protein, from Human, contains 545 amino acids, locates in Nucleus.

May be involved in hepatocellular function and development


This is DNA-binding death effector domain-containing protein 2 protein, from Human, contains 326 amino acids, locates in Nucleus.

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus, May regulate degradation of intermediate filaments during apoptosis, May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3


This is Inhibitor of growth protein 5 protein, from Human, contains 240 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767), Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653), Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653), Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715)


This is Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial protein, from Human, contains 142 amino acids, is soluble, locates in Mitochondrion.

May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure


This is Manganese lipoxygenase protein, from Wheat and barley take-all root rot fungus, contains 618 amino acids, is soluble, locates in Extracellular.

Lipoxygenase that metabolizes linoleic and alpha-linolenic acids to 11S- and 13R-hydroperoxy fatty acids, At the end of lipoxygenation, the intermediate product 11S-HPODE from linoleic acid is then transformed into 13R-HPODE as the final product, It also acts on alpha-linolenic acid producing 11S-HPOTrE and 13R-HPOTrE with subsequent transformation of 11S-HPOTrE to 13R-HPOTrE as the final product, Gamma-linolenic acid is a poor substrate, Oleate and arachidonate are not substrates


This is Manganese lipoxygenase protein, from Oat take-all root rot fungus, contains 618 amino acids, is soluble, locates in Extracellular.

Lipoxygenase that metabolizes linoleic and alpha-linolenic acids to 11S- and 13R-hydroperoxy fatty acids, At the end of lipoxygenation, the intermediate product 11S-HPODE from linoleic acid is then transformed into 13R-HPODE as the final product, It also acts on alpha-linolenic acid producing 11S-HPOTrE and 13R-HPOTrE with subsequent transformation of 11S-HPOTrE to 13R-HPOTrE as final product

Belongs to the lipoxygenase family, Manganese lipoxygenase subfamily


This is Actin filament-associated protein 1 protein, from Chicken, contains 729 amino acids, is soluble, locates in Cytoplasm.

Functions as an adapter molecule that links other proteins to the actin cytoskeleton, May function in facilitating interactions between SRC and actin filaments, May modulate changes in actin filament integrity and induce lamellipodia formation, Can cross-link actin filaments into both network and bundle structures


This is Kininogen-1b protein, from Giant fire-bellied toad, contains 208 amino acids, is soluble, locates in Extracellular.

In vitro, produces constriction of guinea pig ileum smooth muscle, May target bradykinin receptors (BDKRB)

Belongs to the bradykinin-related peptide family


This is Vang-like protein 2-A protein, from African clawed frog, contains 521 amino acids, is membrane-bound, locates in Cell membrane.

Has a role in non-canonical Wnt/planar cell polarity (PCP) signaling; can recruit dvl/dsh and prickle from the cytoplasm to the plasma membrane, Acts in a PCP complex to regulate the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation, Regulates convergent extension cell movements in both dorsal mesoderm and neural tissue during gastrulation, without affecting cell fate, Regulates neural fold closure during neurulation (PubMed:11867525, PubMed:11780127, PubMed:12421719), May be required for cell surface localization of fzd3 and fzd6 in the inner ear (By similarity)


This is Heparanase protein, from Chicken, contains 523 amino acids, is soluble, locates in Extracellular.

Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans, Participates in extracellular matrix (ECM) degradation and remodeling, Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group, Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety (By similarity), Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity


This is Nodal homolog 2-A protein, from African clawed frog, contains 405 amino acids, is soluble, locates in Extracellular.

Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos, Essential for mesoderm formation and axial patterning during embryonic development, Activates the activin-like signaling pathway to induce dorsal and ventral mesoderm in animal cap ectoderm, In addition, also dorsalizes ventral marginal zone (VMZ) tissues during gastrulation, Induces muscle actin, Appears to act as both a short-range and long-range morphogen, The unprocessed protein inhibits bmp- and wnt-signaling


This is Maternal embryonic leucine zipper kinase protein, from African clawed frog, contains 651 amino acids, is membrane-bound, locates in Cell membrane.

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation, Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis (By similarity), Plays a role in cytokinesis during early development

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily


This is DNA replication licensing factor mcm7-A protein, from African clawed frog, contains 720 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development


This is Fat storage-inducing transmembrane protein 1 protein, from Mouse, contains 292 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:18160536, PubMed:22106267) (By similarity), Directly binds to diacylglycerol (DAGs) and triacylglycerol (PubMed:22106267) (By similarity)

Belongs to the FIT family, FIT1 subfamily


This is Nephronectin protein, from Mouse, contains 561 amino acids, is soluble, locates in Extracellular.

Functional ligand of integrin alpha-8/beta-1 in kidney development, Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development, May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins


This is Actin-histidine N-methyltransferase protein, from Mouse, contains 594 amino acids, locates in Nucleus.

Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30626964), Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964), Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964)

Belongs to the class V-like SAM-binding methyltransferase superfamily, SETD3 actin-histidine methyltransferase family


This is Calcium-responsive transcription coactivator protein, from Rat, contains 401 amino acids, locates in Nucleus.

Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons, Recruits CREB-binding protein (CREBBP) to nuclear bodies, Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex, In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex, Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex, At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation, The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP


This is Twinfilin-1 protein, from Mouse, contains 350 amino acids, is soluble, locates in Cytoplasm.

Actin-binding protein involved in motile and morphological processes, Inhibits actin polymerization, likely by sequestering G-actin, By capping the barbed ends of filaments, it also regulates motility, Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles

Belongs to the actin-binding proteins ADF family, Twinfilin subfamily


This is Vang-like protein 2 protein, from Mouse, contains 521 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate, Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea, Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process, Required for cell surface localization of FZD3 and FZD6 in the inner ear (PubMed:16495441)


This is Acid sphingomyelinase-like phosphodiesterase 3a protein, from Human, contains 453 amino acids, is soluble, locates in Extracellular.

Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:25288789, PubMed:26783088), Has in vitro activity with p-nitrophenyl-TMP (PubMed:25288789), Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (PubMed:25288789, PubMed:26783088), Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine, Has in vitro activity with CDP-ethanolamine (PubMed:26783088), Does not have sphingomyelin phosphodiesterase activity (PubMed:25288789, PubMed:26783088)

Belongs to the acid sphingomyelinase family


This is (3R)-3-hydroxyacyl-CoA dehydrogenase protein, from Human, contains 261 amino acids, is soluble, locates in Mitochondrion.

Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS), Alpha-subunit of the KAR complex that acts as a scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis, Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function (PubMed:19571038, PubMed:25203508, PubMed:30508570), Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+) (PubMed:19571038), Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters (Probable) (PubMed:30508570), NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2), Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one), Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol (PubMed:17978863)

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is GPI mannosyltransferase 3 protein, from Human, contains 554 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis, Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly

Belongs to the glycosyltransferase 22 family, PIGB subfamily


This is GPI-anchor transamidase protein, from Human, contains 395 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI, During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein


This is Transcription factor AP-2 gamma protein, from Human, contains 450 amino acids, locates in Nucleus.

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes, AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development, They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC, Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer


This is Endoplasmic reticulum protein SC65 protein, from Human, contains 437 amino acids, locates in Nucleus.

Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils, Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly


This is Leucine-rich repeat-containing protein let-4 protein, from Caenorhabditis elegans, contains 773 amino acids, is membrane-bound, locates in Cell membrane.

Required for apical extracellular matrix organization and epithelial junction maintenance


This is Intraflagellar transport protein che-13 protein, from Caenorhabditis elegans, contains 412 amino acids, is soluble, locates in Cytoplasm.

Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium (PubMed:12651157, PubMed:28479320), May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320), Required for the formation of chemosensory cilia that detect chemosensory cues (PubMed:12651157)


This is Serine/threonine-protein kinase/endoribonuclease IRE1b protein, from Mouse-ear cress, contains 881 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation, The active endoribonuclease domain splices bZIP60 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator which then induces transcription of UPR target genes, Involved in organ growth regulation, Plays a role in plant immunity and abiotic stress responses, Required for ER stress-induced autophagy

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Protein VACUOLELESS1 protein, from Mouse-ear cress, contains 858 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells, Involved in the docking or fusion of prevacuolar vesicles, Important for the function of both male and female gametophytes, but is not essential for the germination and development of pollen


This is NAC domain-containing protein 72 protein, from Mouse-ear cress, contains 297 amino acids, locates in Nucleus.

Transcription factors that bind specifically to the 5'-CATGTG-3' motif and with bipartite regions with 5'-CGTr-3' and 5'-YACG-3' as cores (PubMed:15319476, PubMed:29659022), Involved in the regulation of metabolic reprogramming during senescence by promoting the chloroplast protein degradation and the catabolism of lysine, phytol and free fatty acids via the induction of CV, LKR/SDH and PES1 expression (PubMed:29659022), Triggers also the degradation of starch and the accumulation of mono- and disaccharides during senescence by enhancing the expression of AMY1, SFP1 and SWEET15 (PubMed:29659022)


This is Cysteine desulfurase 1, chloroplastic protein, from Mouse-ear cress, contains 463 amino acids, is soluble, locates in Plastid.

Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine (PubMed:12033984, PubMed:16455656), Supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters (PubMed:15480755, PubMed:17372218), Required for the maturation of all plastidic Fe-S proteins and, thus, essential for plant growth (PubMed:17372218)

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family


This is 4-hydroxybenzoate polyprenyltransferase, mitochondrial protein, from Mouse-ear cress, contains 407 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group, Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate, Required for embryo development

Belongs to the UbiA prenyltransferase family


This is Protein TIFY 9 protein, from Mouse-ear cress, contains 197 amino acids, locates in Nucleus.

Repressor of jasmonate (JA) responses (PubMed:19151223), Interacts with and suppresses RHD6 and RSL1 transcription factor activities to negatively regulate jasmonate-stimulated root hair development (PubMed:31988260)


This is Phospholipase A1-Igamma1, chloroplastic protein, from Mouse-ear cress, contains 515 amino acids, locates in Plastid.

Acylhydrolase with a broad specificity, Catalyzes the hydrolysis of phosphatidylcholine at the sn-1 position, Moderate activity toward phosphatidylcholine (PC), monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and triacylglycerol (TAG), May display dual sn-1/sn-2 substrate specificity, Could be involved in early wound response

Belongs to the AB hydrolase superfamily, Lipase family


This is Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial protein, from Mouse-ear cress, contains 374 amino acids, locates in Mitochondrion.

Performs an essential role in the oxidative function of the citric acid cycle

Belongs to the isocitrate and isopropylmalate dehydrogenases family


This is Chromo domain-containing protein LHP1 protein, from Mouse-ear cress, contains 445 amino acids, locates in Nucleus.

Structural component of heterochromatin involved in gene repression, including several floral homeotic genes and FLT that regulates flowering time (PubMed:9611176), Required for maintenance of vernalization-induced repression of FLC, As part of the PRC1-like complex, recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me), leading to epigenetic repression, PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility, Transcriptional repressor that binds DNA on GAGA-like motif and 5'-(A/G/T)AACCCTA(A/G)-3' consensus motif in the promoters of target genes, Recognizes and binds histone H3 tails methylated at 'Lys-27' (H3K27me) but depleted in active histone marks such as H3K4me, leading to epigenetic repression, When in complex with LHP1, recognizes and binds histone H3 tails methylated at 'Lys-4' (H3K4me) and 'Lys-27' (H3K27me), mostly corresponding to stress-responsive genes (PubMed:27495811)


This is Phospholipase A(1) DAD1, chloroplastic protein, from Mouse-ear cress, contains 447 amino acids, locates in Plastid.

Sn-1-specific phospholipase that releases free fatty acids from phospholipids, Low activity on galactolipids and triacylglycerols, Catalyzes the initial step of jasmonic acid biosynthesis, Not essential for jasmonate biosynthesis after wounding or upon pathogen infection


This is Respiratory burst oxidase homolog protein B protein, from Potato, contains 867 amino acids, is membrane-bound, locates in Cell membrane.

Calcium-dependent NADPH oxidase that generates superoxide, Involved in the massive phase II oxidative burst induced by pathogen infection


This is E3 ubiquitin-protein ligase ariadne-1 protein, from Fruit fly, contains 503 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger, is soluble, locates in Cytoplasm.

RING-type

IBR-type

RING-type 2; atypical

Atypical E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 Ubc10 (PubMed:10880484, PubMed:21900267, PubMed:29689197), Controls the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex (PubMed:29689197), Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation (PubMed:29689197), Appears to function, at least partially redundantly, with the RBR E3 ligase family member park in nuclear localization and morphology (PubMed:29689197), Likely to function in metamorphosis by regulating the proteins levels of EcR isoform A (ECR-A) and its heterodimeric partner usp, via the ubiquitination and subsequent degradation of ECR-A (PubMed:21900267)

Belongs to the RBR family, Ariadne subfamily


This is Photosystem I subunit O protein, from Mouse-ear cress, contains 140 amino acids, is membrane-bound, locates in Plastid.

Involved in the balancing of excitation energy between the two photosystems I (PSI) and II (PSII)


This is Pre-mRNA-splicing factor SPF27 homolog protein, from Mouse-ear cress, contains 253 amino acids, locates in Nucleus.

Component of the MAC complex that probably regulates defense responses through transcriptional control and thereby is essential for plant innate immunity, Involved in mRNA splicing


This is Protein WALLS ARE THIN 1 protein, from Mouse-ear cress, contains 389 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Required for secondary wall formation in fibers, especially in short days conditions, Promotes indole metabolism and transport (e,g, tryptophan, neoglucobrassicin and auxin (indole-3-acetic acid)), May prevent salicylic-acid (SA) accumulation

Belongs to the drug/metabolite transporter (DMT) superfamily, Plant drug/metabolite exporter (P-DME) (TC 2,A,7,4) family


This is AUGMIN subunit 6 protein, from Mouse-ear cress, contains 741 amino acids, is soluble, locates in Cytoplasm.

Contributes to the assembly of the acentrosomal spindle and phragmoplast microtubule arrays as part of the augmin complex


This is Adenylate isopentenyltransferase 7, mitochondrial protein, from Mouse-ear cress, contains 329 amino acids, locates in Mitochondrion.

Involved in cytokinin biosynthesis, Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP


This is Adenylate isopentenyltransferase 5, chloroplastic protein, from Mouse-ear cress, contains 330 amino acids, locates in Plastid.


This is Adenylate isopentenyltransferase 1, chloroplastic protein, from Mouse-ear cress, contains 357 amino acids, locates in Plastid.

Involved in cytokinin biosynthesis, Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP, ADP and AMP, Adenine, adenosine, isopentenylpyrophosphate and 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBDP) are not used as substrates


This is Two pore calcium channel protein 1 protein, from Mouse-ear cress, contains 733 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane, Is one of the essential components of the slow vacuolar (SV) channel, Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition, Involved in the regulation of germination and stomatal movement

Belongs to the calcium channel alpha-1 subunit (TC 1,A,1,11) family, Two pore calcium channel subfamily


This is Legumain protein, from Bovine, contains 433 amino acids, locates in Lysosome/Vacuole.

Has a strict specificity for hydrolysis of asparaginyl bonds, Can also cleave aspartyl bonds slowly, especially under acidic conditions, Required for normal degradation of internalized EGFR, Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity), Required for normal lysosomal protein degradation in renal proximal tubules, May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system


This is Lysosomal amino acid transporter 1 protein, from Caenorhabditis elegans, contains 311 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes (PubMed:22822152), May play a role in the degradation of autophagic substrates in autolysosomes by regulating lysosome function (PubMed:25124690)


This is L-type lectin-domain containing receptor kinase V.5 protein, from Mouse-ear cress, contains 661 amino acids, is membrane-bound, locates in Cell membrane.

Confers resistance to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici, but confers susceptibility to the pathogenic bacteria Pseudomonas syringae

In the N-terminal section; belongs to the leguminous lectin family


This is B-box zinc finger protein 24 protein, from Mouse-ear cress, contains 248 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger, locates in Nucleus.

B box-type 1; atypical

B box-type 2; atypical

Acts as negative regulator of seedling photomorphogenesis and light-regulated inhibition of hypocotyl elongation (PubMed:17605755, PubMed:18540109, PubMed:21685177), BBX24/STO and BBX25/STH function as transcriptional corepressors of HY5 activity, leading to the down-regulation of BBX22 expression, BBX24/STO acts additively with BBX25/STH during de-etiolation and the hypocotyl shade avoidance response (PubMed:23624715), Functions as negative regulator of photomorphogenic UV-B responses by interacting with both COP1 and HY5 (PubMed:22410790), May act as a transcription factor in the salt-stress response (PubMed:12909688)


This is Thymic stromal lymphopoietin protein, from Human, contains 159 amino acids, is soluble, locates in Extracellular.

May act as an antimicrobial peptide in the oral cavity and on the skin


This is Zinc finger protein with KRAB and SCAN domains 4 protein, from Human, contains 545 amino acids, has 7 C2H2-type Zinc finger, locates in Nucleus.

May be involved in the transcriptional activation of MDM2 and EP300 genes

Belongs to the krueppel C2H2-type zinc-finger protein family


This is BOS complex subunit NCLN protein, from Human, contains 563 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261522, PubMed:32820719), The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522), May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity)


This is U3 small nucleolar RNA-associated protein 4 homolog protein, from Human, contains 686 amino acids, locates in Nucleus.

(Microbial infection) Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV


This is Mitochondrial outer membrane protein SLC25A46 protein, from Human, contains 418 amino acids, is membrane-bound, locates in Mitochondrion.

Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization (PubMed:26168012, PubMed:27543974, PubMed:27390132), May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane (PubMed:27390132), Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission (PubMed:27390132)

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Crossover junction endonuclease EME1 protein, from Human, contains 570 amino acids, locates in Nucleus.

Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick, Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions, May be required in mitosis for the processing of stalled or collapsed replication forks


This is Ubiquitin-conjugating enzyme E2 W protein, from Human, contains 151 amino acids, locates in Nucleus.

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386, PubMed:21229326), Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini (PubMed:23560854, PubMed:23696636, PubMed:25436519), Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3, After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:19111657, PubMed:21229326), In vitro catalyzes 'Lys-11'-linked polyubiquitination, UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i,e, lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate (PubMed:25436519)

Belongs to the ubiquitin-conjugating enzyme family


This is Nucleus accumbens-associated protein 2 protein, from Human, contains 587 amino acids, locates in Nucleus.

Functions as a transcriptional repressor through its association with the NuRD complex, Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53


This is Transcriptional adapter 1 protein, from Human, contains 335 amino acids, locates in Nucleus.

Probably involved in transcriptional regulation


This is Peptidylprolyl isomerase domain and WD repeat-containing protein 1 protein, from Human, contains 646 amino acids, locates in Nucleus.

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357), May be involved in pre-mRNA splicing (PubMed:11991638)

Belongs to the cyclophilin-type PPIase family, PPIL1 subfamily


This is Store-operated calcium entry-associated regulatory factor protein, from Human, contains 339 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling, In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions


This is Mitochondrial dynamics protein MID49 protein, from Human, contains 454 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial outer membrane protein involved in the regulation of mitochondrial organization (PubMed:29361167), It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins, Regulates DNM1L GTPase activity


This is ATP-dependent RNA helicase DHX58 protein, from Human, contains 678 amino acids, is soluble, locates in Cytoplasm.

Acts as a regulator of RIGI and IFIH1/MDA5 mediated antiviral signaling, Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events, Can have both negative and positive regulatory functions related to RIGI and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both, Its inhibitory action on RIG-I signaling may involve the following mechanisms: competition with RIGI for binding to the viral RNA, binding to RIGI and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3), Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by RIGI and IFIH1/MDA5, Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes (PubMed:31256877), Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA, Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate

Belongs to the helicase family, RLR subfamily


This is ELL-associated factor 2 protein, from Human, contains 260 amino acids, locates in Nucleus.

Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity), Acts as a transcriptional transactivator of ELL and ELL2 elongation activities, Potent inducer of apoptosis in prostatic and non-prostatic cell lines, Inhibits prostate tumor growth in vivo


This is Leucine-rich repeat-containing protein 45 protein, from Human, contains 670 amino acids, is soluble, locates in Cytoplasm.

Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion


This is U5 small nuclear ribonucleoprotein 40 kDa protein protein, from Human, contains 357 amino acids, locates in Nucleus.

Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30705154), Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome (PubMed:9774689, PubMed:16723661, PubMed:26912367), As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)


This is Endoplasmic reticulum lectin 1 protein, from Human, contains 483 amino acids, is soluble, locates in Endoplasmic reticulum.

Probable lectin that binds selectively to improperly folded lumenal proteins, May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins


This is Transcription termination factor 3, mitochondrial protein, from Human, contains 417 amino acids, locates in Mitochondrion.

Binds promoter DNA and regulates initiation of transcription (PubMed:17662942), Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes, Required for normal mitochondrial function (By similarity), Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity)


This is Arylsulfatase G protein, from Human, contains 525 amino acids, locates in Lysosome/Vacuole.

Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate (PubMed:18283100, PubMed:29300381), Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin (PubMed:22689975)


This is E3 ubiquitin-protein ligase CHFR protein, from Human, contains 664 amino acids, has 1 RING-type Zinc finger, has 1 PBZ-type Zinc finger, locates in Nucleus.

RING-type

PBZ-type

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons, Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus, Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome, Promotes the ubiquitination and subsequent degradation of AURKA and PLK1, Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation, May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer, Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress


This is Cytoplasmic dynein 2 intermediate chain 2 protein, from Human, contains 536 amino acids, is soluble, locates in Cytoplasm.

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways, Inhibits the MAP3K7-induced NF-kappa-B activation pathway, Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation

Belongs to the dynein light intermediate chain family


This is Seipin protein, from Human, contains 398 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:19278620, PubMed:21533227, PubMed:31708432, PubMed:30293840), In association with LDAF1, defines the sites of LD formation in the ER (PubMed:31708432), Also required for growth and maturation of small nascent LDs into larger mature LDs (PubMed:27564575), Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs (PubMed:31178403, PubMed:27879284), Regulates the maturation of ZFYVE1-positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts (PubMed:30970241), Binds anionic phospholipids including phosphatidic acid (PubMed:30293840), Plays an important role in the differentiation and development of adipocytes (By similarity)


This is DCN1-like protein 1 protein, from Human, contains 259 amino acids, locates in Nucleus.

Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954), Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:26906416, PubMed:23201271, PubMed:19617556, PubMed:23401859), Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates, Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483), Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity)


This is SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 protein, from Human, contains 515 amino acids, locates in Nucleus.

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology), Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058), Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex), During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state, The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes, As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF), The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells, The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity), Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE), May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202), Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342), Interacts with AKIRIN2 (By similarity)


This is Methylthioribulose-1-phosphate dehydratase protein, from Human, contains 242 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P), Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation, May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death

Belongs to the aldolase class II family, MtnB subfamily


This is DDRGK domain-containing protein 1 protein, from Human, contains 314 amino acids, locates in Endoplasmic reticulum.

Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) (PubMed:32160526), In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets (PubMed:32160526), Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (PubMed:28128204, PubMed:32160526), Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response (By similarity), Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated, transcription (PubMed:25219498), May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:23675531), Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186)


This is 2-oxoadipate dehydrogenase complex component E1 protein, from Human, contains 919 amino acids, locates in Mitochondrion.

2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC) (PubMed:29191460, PubMed:29752936, PubMed:32303640, PubMed:32633484, PubMed:32695416), Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC (PubMed:29191460, PubMed:32695416), Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (Probable) (PubMed:29752936, PubMed:32303640, PubMed:32633484), Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate (PubMed:29191460, PubMed:29752936, PubMed:32633484, PubMed:32695416), Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate (Probable)

Belongs to the alpha-ketoglutarate dehydrogenase family


This is Splicing factor 45 protein, from Human, contains 401 amino acids, locates in Nucleus.

Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step, Involved in the regulation of alternative splicing and the utilization of cryptic splice sites, Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene, The resulting frameshift leads to sickle cell anemia


This is ELL-associated factor 1 protein, from Human, contains 268 amino acids, locates in Nucleus.

Acts as a transcriptional transactivator of ELL and ELL2 elongation activities


This is Solute carrier family 41 member 2 protein, from Human, contains 573 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a plasma-membrane magnesium transporter (PubMed:16984228), Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+) (By similarity)

Belongs to the SLC41A transporter family


This is (E2-independent) E3 ubiquitin-conjugating enzyme FATS protein, from Human, contains 699 amino acids, is soluble, locates in Cytoplasm.

Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage, Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53, Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2), Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response, Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner, Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity), May have a role in the assembly of primary cilia (Probable)


This is Centriolar and ciliogenesis-associated protein HYLS1 protein, from Human, contains 299 amino acids, is soluble, locates in Cytoplasm.


This is Adenylate kinase 7 protein, from Human, contains 723 amino acids, is soluble, locates in Cytoplasm.

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates, Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP, Also displays broad nucleoside diphosphate kinase activity, Involved in maintaining ciliary structure and function

In the C-terminal section; belongs to the dpy-30 family


This is Centrosomal protein of 63 kDa protein, from Human, contains 703 amino acids, is soluble, locates in Cytoplasm.

Required for normal spindle assembly (PubMed:21406398, PubMed:21983783, PubMed:26297806, PubMed:35793002), Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:21983783, PubMed:26297806), Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806), Also recruits CDK1 to centrosomes (PubMed:21406398), Plays a role in DNA damage response (PubMed:21406398), Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398), Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (PubMed:35989368)


This is YTH domain-containing protein 1 protein, from Human, contains 727 amino acids, locates in Nucleus.

Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244), M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451), Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937), Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937), In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937), May also regulate alternative splice site selection (PubMed:20167602), Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244), Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity), Also recognizes and binds m6A on other RNA molecules (PubMed:27602518), Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518), Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306), Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity)


This is Conserved oligomeric Golgi complex subunit 8 protein, from Human, contains 612 amino acids, is membrane-bound, locates in Golgi apparatus.


This is Zinc finger protein 641 protein, from Human, contains 438 amino acids, has 5 C2H2-type Zinc finger, locates in Nucleus.

Transcriptional activator, Activates transcriptional activities of SRE and AP-1


This is Sodium channel and clathrin linker 1 protein, from Human, contains 688 amino acids, is soluble, locates in Cytoplasm.

Adapter protein that links SCN10A to clathrin, Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity)


This is Crossover junction endonuclease MUS81 protein, from Human, contains 551 amino acids, locates in Nucleus.

Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick, Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions, Plays an essential role in mitosis for the processing of stalled or collapsed replication forks (PubMed:28575661)


This is E3 ubiquitin-protein ligase NEDD4-like protein, from Human, contains 975 amino acids, is soluble, locates in Cytoplasm.

E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:31959741, PubMed:33608556, PubMed:20064473), Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141), Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741), Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1,2, SCN3A/Nav1,3, SCN5A/Nav1,5, SCN9A/Nav1,7, SCN10A/Nav1,8, KCNA3/Kv1,3, KCNH2, EAAT1, KCNQ2/Kv7,2, KCNQ3/Kv7,3 or CLC5 (PubMed:26363003, PubMed:27445338), Promotes ubiquitination and degradation of SGK1 and TNK2, Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046), Plays a role in dendrite formation by melanocytes (PubMed:23999003), Involved in the regulation of TOR signaling (PubMed:27694961), Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338), Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556)


This is CCA tRNA nucleotidyltransferase 1, mitochondrial protein, from Human, contains 434 amino acids, locates in Mitochondrion.

Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro)

Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family


This is Myotubularin-related protein 9 protein, from Human, contains 549 amino acids, is soluble, locates in Cytoplasm.

Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598), Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598), Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity), Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate (PubMed:22647598), The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970), Stabilizes MTMR8 protein levels (PubMed:22647598), Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580), Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598), Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598), Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970)

Belongs to the protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily


This is Solute carrier family 22 member 12 protein, from Human, contains 553 amino acids, is membrane-bound, locates in Cell membrane.

Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:12024214, PubMed:22194875, PubMed:35144162, PubMed:35462902), Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:12024214, PubMed:22194875), Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:12024214), Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (PubMed:12024214), Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption (PubMed:21350910), Orotate transport is Cl(-)-dependent (PubMed:21350910)

Belongs to the major facilitator (TC 2,A,1) superfamily, Organic cation transporter (TC 2,A,1,19) family


This is Cyclin-L2 protein, from Human, contains 520 amino acids, is soluble, locates in Nucleus.

Involved in pre-mRNA splicing, May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors

Belongs to the cyclin family, Cyclin L subfamily


This is RNA-binding protein 15 protein, from Human, contains 977 amino acids, is membrane-bound, locates in Nucleus.

RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518), Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity), Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518), Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518), Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity), Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292), Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity), Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity), May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495), High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495), May be implicated in HOX gene regulation (PubMed:11344311)


This is ATP-dependent zinc metalloprotease YME1L1 protein, from Human, contains 773 amino acids, is membrane-bound, locates in Mitochondrion.

ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26923599, PubMed:27786171), Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975), Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461), Required for normal, constitutive degradation of PRELID1 (PubMed:27495975), Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599), Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461)

In the C-terminal section; belongs to the peptidase M41 family


This is MICOS complex subunit MIC10 protein, from Baker's yeast, contains 97 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Belongs to the MICOS complex subunit Mic10 family


This is Repellent protein 1 protein, from Corn smut fungus, contains 652 amino acids, is soluble, locates in Extracellular.

Water-repellent structural protein required for surface hydrophobicity and formation of aerial hyphae during filamentous growth


This is M-phase phosphoprotein 8 protein, from Human, contains 860 amino acids, locates in Nucleus.

Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416), Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500), Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592), Mediates down-regulation of CDH1 expression (PubMed:20871592), Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark, Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708), The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602)


This is Cell cycle checkpoint control protein RAD9A protein, from Human, contains 391 amino acids, locates in Nucleus.

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair, The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex, Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER), The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates, The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase, RAD9A possesses 3'->5' double stranded DNA exonuclease activity, Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex


This is 3-hydroxyacyl-CoA dehydrogenase type-2 protein, from Human, contains 261 amino acids, locates in Mitochondrion.

In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:24549042, PubMed:25925575, PubMed:26950678, PubMed:28888424), Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705), The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit (PubMed:23042678, PubMed:25925575, PubMed:28888424), The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705), Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Lipopolysaccharide-induced tumor necrosis factor-alpha factor protein, from Human, contains 161 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352), Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades (PubMed:23166352), Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352), Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429), May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005), Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005), May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005)


This is Chemerin-like receptor 1 protein, from Human, contains 373 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2)

Belongs to the chemokine-like receptor (CMKLR) family


This is HAUS augmin-like complex subunit 7 protein, from Human, contains 358 amino acids, is soluble, locates in Cytoplasm.

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex


This is ATP-dependent RNA helicase DHX58 protein, from Mouse, contains 678 amino acids, is soluble, locates in Cytoplasm.

Acts as a regulator of RIGI and IFIH1/MDA5 mediated antiviral signaling, Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events, Can have both negative and positive regulatory functions related to RIGI and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both, Its inhibitory action on RIG-I signaling may involve the following mechanisms: competition with RIGI for binding to the viral RNA, binding to RIGI and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3), Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by RIGI and IFIH1/MDA5, Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes, Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA, Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate


This is Golgi reassembly-stacking protein 2 protein, from Mouse, contains 451 amino acids, is membrane-bound, locates in Golgi apparatus.

Key structural protein of the Golgi apparatus (PubMed:32573693), The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:32573693), Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:32573693), However, other studies suggest that GORASP2 plays a role in assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (By similarity), May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (By similarity), Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (PubMed:28617811), Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity)


This is Non-POU domain-containing octamer-binding protein protein, from Mouse, contains 473 amino acids, locates in Nucleus.

DNA- and RNA binding protein, involved in several nuclear processes, Binds the conventional octamer sequence in double-stranded DNA (PubMed:8355702), Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity), Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (By similarity), Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (By similarity), Together with PSPC1, required for the formation of nuclear paraspeckles (By similarity), The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (By similarity), The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (By similarity), The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (By similarity), In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (By similarity), NONO is involved in transcriptional regulation (By similarity), The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity), NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (PubMed:9001221), Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (PubMed:22966205), Important for the functional organization of GABAergic synapses (PubMed:26571461), Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (PubMed:26571461), Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (PubMed:32286661), Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity)


This is N-acylneuraminate cytidylyltransferase protein, from Mouse, contains 432 amino acids, locates in Nucleus.

Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid, Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)

Belongs to the CMP-NeuNAc synthase family


This is Small vasohibin-binding protein protein, from Mouse, contains 66 amino acids, is soluble, locates in Extracellular.

Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146868, PubMed:31363758, PubMed:35482892), Also required to enhance the solubility and secretion of VASH1 and VASH2 (By similarity), Plays a role in axon and excitatory synapse formation (PubMed:31235911)


This is Urocortin-2 protein, from Mouse, contains 113 amino acids, is soluble, locates in Extracellular.

Suppresses food intake, delays gastric emptying and decreases heat-induced edema, Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity)

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family


This is Protein bicaudal C homolog 1 protein, from Mouse, contains 977 amino acids, is soluble, locates in Cytoplasm.

Putative RNA-binding protein, May be involved in regulating gene expression during embryonic development


This is Serine protease 29 protein, from Mouse, contains 279 amino acids, is soluble, locates in Extracellular.

Involved in embryo hatching and implantation


This is Testis-expressed protein 19.1 protein, from Mouse, contains 351 amino acids, is soluble, locates in Cytoplasm.

Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and preventing their mobilization (PubMed:18802469, PubMed:21103378, PubMed:23364048, PubMed:23674551, PubMed:28254886), With its paralog, Tex19,2, collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:28254886), Also during spermatogenesis, promotes, with UBR2, SPO11-dependent meiotic recombination (PubMed:28708824), Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172)


This is Acetyl-coenzyme A synthetase 2-like, mitochondrial protein, from Mouse, contains 682 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:11150295, PubMed:16790548), Acetate is the preferred substrate (PubMed:11150295, PubMed:16790548), Can also utilize propionate with a much lower affinity (PubMed:11150295), Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (PubMed:11150295), Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (PubMed:19187775)

Belongs to the ATP-dependent AMP-binding enzyme family


This is Peroxisomal coenzyme A diphosphatase NUDT7 protein, from Mouse, contains 236 amino acids, locates in Peroxisome.

Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (PubMed:11415433, PubMed:18799520, PubMed:29378847), Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (PubMed:11415433), Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (PubMed:18799520), Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (PubMed:18799520), May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (PubMed:18799520), Does not play a role in U8 snoRNA decapping activity (PubMed:21070968), Binds U8 snoRNA (PubMed:21070968), Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673)

Belongs to the Nudix hydrolase family, PCD1 subfamily


This is Tripartite motif-containing protein 12A protein, from Mouse, contains 284 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

B box-type


This is Structure-specific endonuclease subunit SLX1 protein, from Human, contains 275 amino acids, has 1 SLX1-type Zinc finger, locates in Nucleus.

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination, Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA, Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs), Resolves HJs by generating two pairs of ligatable, nicked duplex products


This is Histone H4 transcription factor protein, from Human, contains 517 amino acids, has 8 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger, locates in Nucleus.

C2H2-type 4; degenerate

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter, Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT, Also activates transcription of the ATM and PRKDC genes, Autoregulates its expression by associating with its own promoter


This is Sclerostin protein, from Human, contains 213 amino acids, is soluble, locates in Extracellular.

Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation


This is Golgi reassembly-stacking protein 1 protein, from Human, contains 440 amino acids, is membrane-bound, locates in Golgi apparatus.

Key structural protein of the Golgi apparatus (PubMed:33301566), The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566), Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566), However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity), Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity), Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344), Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936)


This is Coronin-1B protein, from Human, contains 489 amino acids, is soluble, locates in Cytoplasm.

Regulates leading edge dynamics and cell motility in fibroblasts, May be involved in cytokinesis and signal transduction (By similarity)


This is Fanconi anemia core complex-associated protein 24 protein, from Human, contains 215 amino acids, locates in Nucleus.

Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA, Regulates FANCD2 monoubiquitination upon DNA damage, Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed, Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA


This is Ribonuclease P protein subunit p25 protein, from Human, contains 199 amino acids, locates in Nucleus.

Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:12003489, PubMed:16723659, PubMed:30454648), Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465)


This is Mitochondrial adenyl nucleotide antiporter SLC25A23 protein, from Human, contains 468 amino acids, is membrane-bound, locates in Mitochondrion.

Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane, Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter, By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways (PubMed:15123600), Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP (PubMed:24430870, PubMed:28695448), In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600)

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is U3 small nucleolar RNA-associated protein 14 homolog A protein, from Human, contains 771 amino acids, locates in Nucleus.


This is BOS complex subunit TMEM147 protein, from Human, contains 224 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522), The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522), Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (PubMed:21056967), Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (PubMed:21056967), Regulates LBR localization to the nucleus inner membrane (PubMed:32694168)


This is Katanin p60 ATPase-containing subunit A-like 1 protein, from Human, contains 490 amino acids, is soluble, locates in Cytoplasm.

Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility, Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity), Has microtubule-severing activity in vitro (PubMed:26929214)

Belongs to the AAA ATPase family, Katanin p60 subunit A1 subfamily, A-like 1 sub-subfamily


This is Transcriptional repressor scratch 1 protein, from Human, contains 348 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; atypical Zinc finger, locates in Nucleus.

C2H2-type 5; atypical

Transcriptional repressor that binds E-box motif CAGGTG, Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation

Belongs to the snail C2H2-type zinc-finger protein family


This is Sphingosine-1-phosphate phosphatase 1 protein, from Human, contains 441 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P, Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891), Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:12815058, PubMed:11756451, PubMed:16782891), Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:11756451, PubMed:12815058, PubMed:16782891), Involved in efficient ceramide synthesis from exogenous sphingoid bases, Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase, In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity), Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (PubMed:16782891), The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity), Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713), Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:20798685, PubMed:18583713), Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity)

Belongs to the type 2 lipid phosphate phosphatase family


This is Oxysterol-binding protein-related protein 10 protein, from Human, contains 764 amino acids, is soluble, locates in Cytoplasm.

Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane, Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable), Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302), Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437), Binds cholesterol and acidic phospholipids (PubMed:22906437), Also binds 25-hydroxycholesterol (PubMed:17428193), Binds phosphatidylserine (PubMed:23934110)


This is Isopentenyl-diphosphate delta-isomerase 2 protein, from Human, contains 227 amino acids, locates in Peroxisome.

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)

Belongs to the IPP isomerase type 1 family


This is Gasdermin-C protein, from Human, contains 508 amino acids, is soluble, locates in Cytoplasm.

Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:27281216), Released upon cleavage and binds to membrane inner leaflet lipids, Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (By similarity), The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (Probable)


This is Endoplasmic reticulum junction formation protein lunapark protein, from Human, contains 428 amino acids, has 1 C4-type; plays a role in ER morphology Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

C4-type; plays a role in ER morphology

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983), Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977), May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289), May be involved in limb development (By similarity), Is involved in central nervous system development (PubMed:30032983)


This is Cell division topological specificity factor homolog, chloroplastic protein, from Mouse-ear cress, contains 229 amino acids, locates in Plastid.

Acts as a topological specificity factor during plastid division and specify plastid constriction sites (such as the Z-ring) in a MCD1-dependent manner (PubMed:29967285, PubMed:23936263), Especially involved in epidermal plastids division in a FTSZ1-dependent manner (PubMed:26500667), Required for the proper formation of FtsZ rings at the division site in nongreen plastids (e,g, etioplasts) (PubMed:23936263), May contribute to gravitropism in stems and hypocotyls, Stimulates MIND1 ATPase activity, In cooperation with MIND1, prevents FtsZ ring formation anywhere outside of the mid-plastids


This is Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3 protein, from Mouse-ear cress, contains 669 amino acids, locates in Nucleus.

Histone methyltransferase, Methylates 'Lys-9' of histone H3, H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar3-9 subfamily


This is Protein-tyrosine-phosphatase MKP1 protein, from Mouse-ear cress, contains 784 amino acids, is soluble, locates in Cytoplasm.

Protein-tyrosine-phosphatase that acts as a negative regulator of MPK6 and MPK3 signaling by dephosphorylating and repressing MPK6 and MPK3, Modulates defense response by repressing salicylic acid (SA) production, camalexin biosynthesis and SNC1-mediated responses, Acts as a negative regulator of MPK6-mediated pathogen-associated molecular pattern (PAMP) responses, including MPK6 and MPK3 activation, accumulation of extracellular reactive oxygen species and inhibition of seedling growth, Involved in UV-B stress tolerance, May be involved in salt and genotoxic stress responses


This is Serine/threonine-protein kinase/endoribonuclease IRE1a protein, from Mouse-ear cress, contains 841 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation, The active endoribonuclease domain splices bZIP60 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator which then induces transcription of UPR target genes, Involved in organ growth regulation, Plays a role in plant immunity and abiotic stress responses

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Protein decapping 5 protein, from Mouse-ear cress, contains 611 amino acids, is soluble, locates in Cytoplasm.

As a component of the decapping complex, involved in the degradation of mRNAs, Promotes P-body formation, Translational repressor


This is Phospholipase A1-Igamma3, chloroplastic protein, from Mouse-ear cress, contains 527 amino acids, locates in Plastid.

Acylhydrolase that catalyzes the hydrolysis of phosphatidylcholine at the sn-1 position, Moderate activity toward phosphatidylcholine (PC), monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and triacylglycerol (TAG)

Belongs to the AB hydrolase superfamily, Lipase family


This is Serine/threonine-protein kinase WAG1 protein, from Mouse-ear cress, contains 476 amino acids, is soluble, locates in Cytoplasm.

Serine/threonine-protein kinase involved in the regulation of auxin signaling, Acts as a positive regulator of cellular auxin efflux and regulates organ development by enhancing PIN-mediated polar auxin transport, Phosphorylates conserved serine residues in the PIN auxin efflux carriers, Phosphorylation of PIN proteins is required and sufficient for apical-basal PIN polarity that enables directional intercellular auxin fluxes, which mediate differential growth, tissue patterning and organogenesis, Acts as suppressors of root waving


This is Protein SENSITIVE TO PROTON RHIZOTOXICITY 1 protein, from Mouse-ear cress, contains 499 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, locates in Nucleus.

C2H2-type 2; atypical

Probable transcription factor, Together with STOP2, plays a critical role in tolerance to major stress factors in acid soils such as proton H(+) and aluminum ion Al(3+), Required for the expression of genes in response to acidic stress (e,g, ALMT1 and MATE), and Al-activated citrate exudation