{
 "approved_by_author": "\u231b",
 "citation": "Minteer, C. J., et al. (2023). More than bad luck: Cancer and aging are linked to replication-driven changes to the epigenome. Science Advances, 9(29), eadf4163.",
 "citations": 29,
 "citations_date": "2026-10-02",
 "clock_name": "celldrift",
 "data_type": "DNA methylation",
 "doi": "https://doi.org/10.1126/sciadv.adf4163",
 "journal": "Science Advances",
 "last_author": "Morgan E. Levine",
 "model_type": "PCA + elastic net regression",
 "n_features": 2322,
 "notes": "Replication signature trained on 31 serially passaged hTERT-immortalized human astrocyte samples. The released 62-PC elastic-net predictor over 2,322 CpGs is folded algebraically into a single linear score. Output is calibrated to cumulative population doublings, not years. Original-author missingness is preserved: supplied NaNs become zero, whereas absent CpGs use module means. GitHub commit 066b3e816795f3c0b372ff8d33f59185a490bd8b; DOI 10.5281/zenodo.7693699. Upstream software license is unspecified (Zenodo: Other (Open)).",
 "platform": [
  "Illumina EPIC"
 ],
 "population": "human cell cultures",
 "predicts": [
  "mitotic age"
 ],
 "preprocess": "supplied NaNs to zero; absent CpGs to module means",
 "reference_values": true,
 "research_only": null,
 "species": "Homo sapiens",
 "tissue": [
  "cultured human cells"
 ],
 "training_target": [
  "population doublings"
 ],
 "unit": [
  "population doublings"
 ],
 "version": "0.5.4",
 "year": 2023
}