---
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
---

# dnamic

Whole-blood DNA-methylation predictor of intrinsic capacity, an average score across cognition, locomotion, psychological, sensory, and vitality domains; trained with tenfold cross-validated elastic net on INSPIRE-T and returning higher values for better capacity.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

| | |
|---|---|
| **Predicts** | intrinsic capacity |
| **Species** | Homo sapiens |
| **Tissue** | whole blood |
| **Data type** | DNA methylation |
| **Model type** | elastic net regression |
| **Year** | 2025 |

## Use with pyaging

```python
import pyaging as pya

pya.pred.predict_age(adata, ["dnamic"])
```

Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).

## Citation

Fuentealba, M., Rouch, L., Guyonnet, S. et al. A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors. Nature Aging 5, 1207–1216 (2025).

https://doi.org/10.1038/s43587-025-00883-5