{ "approved_by_author": "\u231b", "citation": "Fuentealba, M., Rouch, L., Guyonnet, S. et al. A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors. Nature Aging 5, 1207\u20131216 (2025).", "citations": 45, "citations_date": "2026-10-02", "clock_name": "dnamic", "data_type": "DNA methylation", "doi": "https://doi.org/10.1038/s43587-025-00883-5", "journal": "Nature Aging", "last_author": "David Furman", "model_type": "elastic net regression", "n_features": 91, "notes": "Whole-blood DNA-methylation predictor of intrinsic capacity, an average score across cognition, locomotion, psychological, sensory, and vitality domains; trained with tenfold cross-validated elastic net on INSPIRE-T and returning higher values for better capacity.", "platform": [ "Illumina EPIC" ], "population": "older adults", "predicts": [ "intrinsic capacity" ], "research_only": null, "species": "Homo sapiens", "tissue": [ "whole blood" ], "training_target": [ "intrinsic capacity" ], "unit": [ "unitless" ], "version": "0.5.7", "year": 2025 }