---
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
---

# downsyndrome

Implementation-derived Down-syndrome-associated methylation projection score: pyaging computes a zero-intercept weighted sum of 652 neonatal blood-spot beta values using the paper's autosomal EWAS beta_overall effect estimates. The paper presents an EWAS, not a trained or validated Down syndrome classifier.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

| | |
|---|---|
| **Predicts** | Down syndrome methylation score |
| **Species** | Homo sapiens |
| **Tissue** | neonatal blood spots |
| **Data type** | DNA methylation |
| **Model type** | weighted linear score |
| **Year** | 2021 |

## Use with pyaging

```python
import pyaging as pya

pya.pred.predict_age(adata, ["downsyndrome"])
```

Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).

## Citation

Muskens, Ivo S., et al. "The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis." Nature Communications 12 (2021): 821.

https://doi.org/10.1038/s41467-021-21064-z