{
 "approved_by_author": "\u231b",
 "citation": "Muskens, Ivo S., et al. \"The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.\" Nature Communications 12 (2021): 821.",
 "citations": 64,
 "citations_date": "2026-10-02",
 "clock_name": "downsyndrome",
 "data_type": "DNA methylation",
 "doi": "https://doi.org/10.1038/s41467-021-21064-z",
 "journal": "Nature Communications",
 "last_author": "Adam J. de Smith",
 "model_type": "weighted linear score",
 "n_features": 652,
 "notes": "Implementation-derived Down-syndrome-associated methylation projection score: pyaging computes a zero-intercept weighted sum of 652 neonatal blood-spot beta values using the paper's autosomal EWAS beta_overall effect estimates. The paper presents an EWAS, not a trained or validated Down syndrome classifier.",
 "platform": [
  "Illumina EPIC"
 ],
 "population": "newborns",
 "predicts": [
  "Down syndrome methylation score"
 ],
 "research_only": null,
 "species": "Homo sapiens",
 "tissue": [
  "neonatal blood spots"
 ],
 "training_target": [
  "not applicable"
 ],
 "unit": [
  "unitless"
 ],
 "version": "0.5.7",
 "year": 2021
}