---
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
---

# ensembleagehumanmouse

Cross-species static EnsembleAge model trained on merged human and mouse methylation data; age is normalized by species maximum lifespan.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

| | |
|---|---|
| **Predicts** | relative age |
| **Species** | Homo sapiens and Mus musculus |
| **Tissue** | multi-tissue, whole blood |
| **Data type** | DNA methylation |
| **Model type** | elastic net regression |
| **Year** | 2025 |

## Use with pyaging

```python
import pyaging as pya

pya.pred.predict_age(adata, ["ensembleagehumanmouse"])
```

Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).

## Citation

Haghani, A. et al. EnsembleAge: enhancing epigenetic age assessment with a multi-clock framework. GeroScience 48, 2873-2886 (2025).

https://doi.org/10.1007/s11357-025-01808-1