{
 "approved_by_author": "\u231b",
 "citation": "Duran-Ferrer, M., et al. \"The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome.\" Nature Cancer 1 (2020): 1066-1081.",
 "citations": 109,
 "citations_date": "2026-10-02",
 "clock_name": "epicmithyper",
 "data_type": "DNA methylation",
 "doi": "https://doi.org/10.1038/s43018-020-00131-2",
 "journal": "Nature Cancer",
 "last_author": "Jos\u00e9 I. Mart\u00edn-Subero",
 "model_type": "mean methylation aggregation",
 "n_features": 184,
 "notes": "Hypermethylation component of epiCMIT: a 184-CpG score ranging from 0 to 1 that tracks low-to-high relative proliferative history in normal and neoplastic B cells.",
 "platform": [
  "Illumina 450K",
  "Illumina EPIC"
 ],
 "population": "human, age unspecified",
 "predicts": [
  "mitotic age"
 ],
 "preprocess": "mean",
 "reference_values": true,
 "research_only": null,
 "species": "Homo sapiens",
 "tissue": [
  "B cells"
 ],
 "training_target": [
  "replicative history"
 ],
 "unit": [
  "proportion"
 ],
 "version": "0.5.7",
 "year": 2020
}