{
 "approved_by_author": "\u231b",
 "citation": "Xu, R.-H., et al. \u201cCirculating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma.\u201d Nature Materials 16: 1155\u20131161 (2017).",
 "citations": 900,
 "citations_date": "2026-10-02",
 "clock_name": "hepatoxu",
 "data_type": "DNA methylation",
 "doi": "https://doi.org/10.1038/nmat4997",
 "journal": "Nature Materials",
 "last_author": "Kang Zhang",
 "model_type": "feature-selected logistic regression",
 "n_features": 10,
 "notes": "Ten-marker plasma cfDNA methylation logistic model producing the combined HCC diagnosis score (cd-score); this packaged model does not implement the separate eight-marker prognosis score.",
 "platform": [
  "targeted bisulfite sequencing"
 ],
 "population": "adults",
 "predicts": [
  "hepatocellular carcinoma"
 ],
 "research_only": null,
 "species": "Homo sapiens",
 "tissue": [
  "plasma cell-free DNA"
 ],
 "training_target": [
  "hepatocellular carcinoma"
 ],
 "unit": [
  "unitless"
 ],
 "version": "0.5.7",
 "year": 2017
}