---
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
---

# mammalian1

Universal pan-mammalian clock 1: elastic-net regression of log-transformed chronological age on conserved mammalian-array CpGs, back-transformed to years.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

| | |
|---|---|
| **Predicts** | chronological age |
| **Species** | multiple species |
| **Tissue** | multi-tissue |
| **Data type** | DNA methylation |
| **Model type** | elastic net regression |
| **Year** | 2023 |

## Use with pyaging

```python
import pyaging as pya

pya.pred.predict_age(adata, ["mammalian1"])
```

Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).

## Citation

Lu, A. T., et al. "Universal DNA methylation age across mammalian tissues." Nature Aging 3.9 (2023): 1144-1166.

https://doi.org/10.1038/s43587-023-00462-6