{
 "approved_by_author": "\u231b",
 "citation": "Thrush, K. L., Bennett, D. A., Gaiteri, C., Horvath, S., van Dyck, C. H., Higgins-Chen, A. T., and Levine, M. E. (2022). Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer\u2019s disease. Aging 14(14), 5641\u20135668.",
 "citations": 40,
 "citations_date": "2026-10-02",
 "clock_name": "pcbrainage",
 "data_type": "DNA methylation",
 "doi": "https://doi.org/10.18632/aging.204196",
 "journal": "Aging",
 "last_author": "Morgan E. Levine",
 "model_type": "PCA + elastic net regression",
 "n_features": 357852,
 "notes": "Brain chronological-age clock trained in dorsolateral prefrontal cortex. The original PCA and regression are composed algebraically without retraining; missing CpGs use the authors\u2019 GSE74193 adult brain means. No age-acceleration residualization is performed.",
 "platform": [
  "Illumina 450K"
 ],
 "population": "adults",
 "predicts": [
  "chronological age"
 ],
 "reference_values": true,
 "research_only": null,
 "species": "Homo sapiens",
 "tissue": [
  "brain cortex"
 ],
 "training_target": [
  "chronological age"
 ],
 "unit": [
  "years"
 ],
 "version": "0.5.4",
 "year": 2022
}