---
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
---

# replitali

Final RepliTali model estimating relative cumulative replicative history from methylation in common partially methylated domains; it was fitted to normalized population doublings across serially cultured primary human cells.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

| | |
|---|---|
| **Predicts** | replicative history |
| **Species** | Homo sapiens |
| **Tissue** | cultured primary human cells |
| **Data type** | DNA methylation |
| **Model type** | elastic net regression |
| **Year** | 2022 |

## Use with pyaging

```python
import pyaging as pya

pya.pred.predict_age(adata, ["replitali"])
```

Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).

## Citation

Endicott, J.L., Nolte, P.A., Shen, H. & Laird, P.W. Cell division drives DNA methylation loss in late-replicating domains in primary human cells. Nature Communications 13, 6659 (2022).

https://doi.org/10.1038/s41467-022-34268-8