{
 "approved_by_author": "\u231b",
 "citation": "Endicott, J.L., Nolte, P.A., Shen, H. & Laird, P.W. Cell division drives DNA methylation loss in late-replicating domains in primary human cells. Nature Communications 13, 6659 (2022).",
 "citations": 93,
 "citations_date": "2026-10-02",
 "clock_name": "replitali",
 "data_type": "DNA methylation",
 "doi": "https://doi.org/10.1038/s41467-022-34268-8",
 "journal": "Nature Communications",
 "last_author": "Peter W. Laird",
 "model_type": "elastic net regression",
 "n_features": 87,
 "notes": "Final RepliTali model estimating relative cumulative replicative history from methylation in common partially methylated domains; it was fitted to normalized population doublings across serially cultured primary human cells.",
 "platform": [
  "Illumina EPIC"
 ],
 "population": "human cell cultures",
 "predicts": [
  "replicative history"
 ],
 "research_only": null,
 "species": "Homo sapiens",
 "tissue": [
  "cultured primary human cells"
 ],
 "training_target": [
  "population doublings"
 ],
 "unit": [
  "population doublings"
 ],
 "version": "0.5.7",
 "year": 2022
}