---
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
---

# retroelementagev2

Composite Retroelement-Age V2 extends the retroelement annotation to CpGs compatible across EPIC v1.0 and v2.0 and was trained by 10-fold-cross-validated elastic net.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

| | |
|---|---|
| **Predicts** | chronological age |
| **Species** | Homo sapiens |
| **Tissue** | whole blood |
| **Data type** | DNA methylation |
| **Model type** | elastic net regression |
| **Year** | 2024 |

## Use with pyaging

```python
import pyaging as pya

pya.pred.predict_age(adata, ["retroelementagev2"])
```

Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).

## Citation

Ndhlovu, Lishomwa C., et al. "Retro-age: A unique epigenetic biomarker of aging captured by DNA methylation states of retroelements." Aging Cell 23 (2024): e14288.

https://doi.org/10.1111/acel.14288