{
 "approved_by_author": "\u231b",
 "citation": "Wang, Y. et al. DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy. BMC Genomics 22, 484 (2021).",
 "citations": 38,
 "citations_date": "2026-07-05",
 "clock_name": "xchrom",
 "data_type": "DNA methylation",
 "doi": "https://doi.org/10.1186/s12864-021-07675-2",
 "journal": "BMC Genomics",
 "last_author": "Leonard C. Schalkwyk",
 "model_type": "principal component analysis",
 "n_features": 4047,
 "notes": "X-chromosome first-principal-component score used with the Y score to infer X dosage and classify 46,XX, 46,XY, 45,X, and 47,XXY samples.",
 "platform": [
  "Illumina 450K",
  "Illumina EPIC"
 ],
 "population": "adults",
 "predicts": [
  "X-chromosome dosage"
 ],
 "preprocess": "sex_estimation_autosomal_zscore",
 "reference_values": true,
 "research_only": null,
 "species": "Homo sapiens",
 "tissue": [
  "whole blood"
 ],
 "training_target": [
  "X-chromosome dosage"
 ],
 "unit": [
  "unitless"
 ],
 "version": "0.5.0",
 "year": 2021
}