[ { "id": "A5IKJ0", "title": "Cell wall synthesis", "fields": { "function": "Cell wall formation.", "catalytic activity": "UDP-N-acetyl-alpha-D-muramate + L-alanine + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanine + ADP + phosphate + H(+)", "pathway": "Cell wall biogenesis; peptidoglycan biosynthesis.", "similarity": "Belongs to the MurCDEF family." } }, { "id": "B9LSR7", "title": "RNA binding", "fields": { "function": "Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.", "subunit": "Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.", "similarity": "Belongs to the universal ribosomal protein uL14 family." } }, { "id": "Q1CJV7", "title": "DNA repair", "fields": { "function": "DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.", "catalytic activity": "NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide.", "similarity": "Belongs to the NAD-dependent DNA ligase family. LigA subfamily." } }, { "id": "A9MXA7", "title": "ATP synthesis", "fields": { "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.", "subunit": "F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.", "similarity": "Belongs to the ATPase gamma chain family." } }, { "id": "Q9REQ9", "title": "RNA methylation", "fields": { "function": "Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.", "catalytic activity": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)", "similarity": "Belongs to the methyltransferase superfamily. RsmH family." } }, { "id": "Q3B3L6", "title": "Peptidyl-tRNA hydrolysis", "fields": { "function": "Hydrolyzes ribosome-free peptidyl-tRNAs (with 1 or more amino acids incorporated), which drop off the ribosome during protein synthesis, or as a result of ribosome stalling.", "catalytic activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)", "subunit": "Monomer.", "similarity": "Belongs to the PTH family." } } ]