"""Deterministic fixed-effect heterogeneity calculation, independently checked with Wolfram. No external service/API calls. Input arrays MUST be effect sizes and standard errors obtained from authentic comparable studies before scientific use. A pooled value is descriptive only, not proof of consensus or causal effect. """ from math import isfinite, sqrt def inverse_variance_heterogeneity(effects: list[float], standard_errors: list[float]) -> dict: if len(effects) != len(standard_errors) or len(effects) < 2: raise ValueError("Need at least two matching effects and standard errors") if any(not isfinite(float(v)) for v in effects): raise ValueError("Effects must be finite") if any(not isfinite(float(se)) or float(se) <= 0 for se in standard_errors): raise ValueError("Standard errors must be finite positive numbers") weights = [1.0 / (float(se) ** 2) for se in standard_errors] pooled = sum(w * v for w, v in zip(weights, effects)) / sum(weights) q = sum(w * (float(v) - pooled) ** 2 for w, v in zip(weights, effects)) dof = len(effects) - 1 i2 = max(0.0, (q - dof) / q) if q > 0 else 0.0 stderr = sqrt(1.0 / sum(weights)) return { "pooled_effect": pooled, "standard_error": stderr, "ci95": [pooled - 1.96 * stderr, pooled + 1.96 * stderr], "Q": q, "degrees_of_freedom": dof, "I2": i2, "warning": "Do not pool incomparable outcomes or interpret this result as independent scientific validation.", }