{
  "type": "object",
  "properties": {
    "nct_id": {
      "type": "string",
      "description": "The ClinicalTrials.gov identifier (e.g. NCT12345678)."
    },
    "targets": {
      "type": "array",
      "description": "Primary biological targets modulated or studied in this trial.",
      "items": {
        "type": "object",
        "properties": {
          "name": {
            "type": "string",
            "description": "Standard name of the target (e.g. TARDBP, SOD1, riluzole, neuroinflammation). Use canonical gene symbols where applicable."
          },
          "type": {
            "type": "string",
            "enum": ["Gene", "Protein", "Compound", "Mechanism"],
            "description": "Category of the target."
          },
          "confidence": {
            "type": "number",
            "minimum": 0.0,
            "maximum": 1.0,
            "description": "Confidence that this is the intended biological target (1.0 = explicit in text)."
          }
        },
        "required": ["name", "type", "confidence"]
      }
    }
  },
  "required": ["nct_id", "targets"]
}