from __future__ import annotations import base64 from io import BytesIO from math import erf, sqrt import numpy as np def load_npz_text(path) -> dict[str, np.ndarray]: encoded = open(path, "rt", encoding="ascii").read() with np.load(BytesIO(base64.b64decode(encoded))) as archive: return {name: archive[name] for name in archive.files} def linear(x: np.ndarray, weight: np.ndarray, bias: np.ndarray) -> np.ndarray: return x @ weight.T + bias def layer_norm( x: np.ndarray, weight: np.ndarray, bias: np.ndarray, eps: float = 1e-5, ) -> np.ndarray: mean = x.mean(axis=-1, keepdims=True) variance = ((x - mean) ** 2).mean(axis=-1, keepdims=True) normalized = (x - mean) / np.sqrt(variance + eps) return normalized * weight + bias def gelu(x: np.ndarray) -> np.ndarray: erf_values = np.vectorize(erf, otypes=[np.float32])(x / sqrt(2.0)) return 0.5 * x * (1.0 + erf_values) class NumpyStableGateDANN: """Inference-only StableGate-Hybrid DANN disease-classification branch.""" def __init__(self, weights_path): self.weights = load_npz_text(weights_path) def predict_logits(self, expression: np.ndarray) -> np.ndarray: weights = self.weights x = np.asarray(expression, dtype=np.float32) * weights["gate_mask"] x = linear(x, weights["input_projection.0.weight"], weights["input_projection.0.bias"]) x = layer_norm(x, weights["input_projection.1.weight"], weights["input_projection.1.bias"]) x = gelu(x) block_input = x x = layer_norm(x, weights["encoder.0.block.0.weight"], weights["encoder.0.block.0.bias"]) x = linear(x, weights["encoder.0.block.1.weight"], weights["encoder.0.block.1.bias"]) x = gelu(x) x = linear(x, weights["encoder.0.block.4.weight"], weights["encoder.0.block.4.bias"]) x = block_input + x x = layer_norm(x, weights["projection_head.0.weight"], weights["projection_head.0.bias"]) x = linear(x, weights["projection_head.1.weight"], weights["projection_head.1.bias"]) x = gelu(x) x = linear(x, weights["projection_head.4.weight"], weights["projection_head.4.bias"]) x = layer_norm(x, weights["projection_head.5.weight"], weights["projection_head.5.bias"]) x = linear(x, weights["disease_classifier.0.weight"], weights["disease_classifier.0.bias"]) x = gelu(x) return linear(x, weights["disease_classifier.3.weight"], weights["disease_classifier.3.bias"])