FUNCTION: Ion channel inhibitor. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 17 (Hntx-9) subfamily.


FUNCTION: Monoterpene synthase that catalyzes the hydrolysis of neryl diphosphate (NPP) to form nerol and diphosphate (PubMed:24124526). Is specific for NPP and has no hydrolase activity toward geranyl diphosphate (GPP) or farnesyl diphosphate (FPP) (PubMed:24124526). The monoterpene nerol may have an insect repellent effect for the plant leaves (PubMed:24124526). SUBCELLULAR LOCATION: Plastid, chloroplast. SIMILARITY: Belongs to the terpene synthase family.


FUNCTION: Required for renal function. SUBCELLULAR LOCATION: Cell projection, cilium.


FUNCTION: Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue. FUNCTION: May contribute to protection against cold-induced oxidative stress. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.


SIMILARITY: Belongs to the UPF0741 family.


SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the protease inhibitor I13 (potato type I serine protease inhibitor) family.


FUNCTION: Small subunit of the DNA topoisomerase that untwists superhelical DNA. Controls topological states of double-stranded DNA by transient breakage and subsequent rejoining of DNA strands.


FUNCTION: Catalyzes the hydrolysis of a non-reducing terminal alpha-L- arabinopyranosidic linkage in ginsenoside Rb2 (alpha-L- arabinopyranosyl-(1->6)-alpha-D-glucopyranosyl) to release alpha-D- glucopyranosyl (Rd). It is not able to hydrolyze alpha-L- arabinofuranosyl-(1->6)-alpha-D-glucopyranosyl (Rc). SIMILARITY: Belongs to the glycosyl hydrolase 3 family.


FUNCTION: Blocks ryanodine receptors, and potassium channels. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the CRISP family.


FUNCTION: Probably part of the binding-protein-dependent transport system y4oPQRS. This system probably transports a sugar-like molecule. SUBCELLULAR LOCATION: Periplasm. SIMILARITY: Belongs to the bacterial solute-binding protein 1 family.


FUNCTION: Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity). This toxin acts on sphingomyelin (SM) (By similarity). It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity). It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity). Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the arthropod phospholipase D family. Class I subfamily.


FUNCTION: Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (By similarity). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (By similarity). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC) (By similarity). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (PubMed:21126536) (By similarity). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation- induced cell death (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the high motility group (HMG) box superfamily.


FUNCTION: Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.


FUNCTION: Involved in the presentation of foreign antigens to the immune system. SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein. SIMILARITY: Belongs to the MHC class I family.


FUNCTION: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity). In embryos, may function redundantly with hmg-4 to promote cell cycle progression and development of the anterior pharynx (PubMed:30336114). In the germline, acts non-redundantly with hmg-4 to play a role in oocyte development (PubMed:30336114). SUBCELLULAR LOCATION: Nucleus Chromosome. SIMILARITY: Belongs to the SSRP1 family.


FUNCTION: Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:10570973). Negatively regulates BMP signaling (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the SLC33A transporter family.


SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the small heat shock protein (HSP20) family.


FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the nuclear hormone receptor family. NR2 subfamily.


FUNCTION: Plays an important role in slowing down the growth of mycobacteria within the infected host. FUNCTION: Plays an important role in slowing down the growth of mycobacteria within the infected host (PubMed:19341393). Activates the peroxidase activity of Rv2159c in a phosphorylation independent manner during oxidative stress conditions and thereby maintains the cellular homeostasis (PubMed:27818650). SUBCELLULAR LOCATION: Cytoplasm Cell membrane; Single-pass membrane protein Note=More abundant in the cytosol than in the cell membrane. SUBCELLULAR LOCATION: Cytoplasm Cell membrane; Single-pass membrane protein. SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


FUNCTION: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano- cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. SUBCELLULAR LOCATION: Cytoplasm. SUBCELLULAR LOCATION: Cytoplasm Note=Released into the host cell cytosol during infection. SIMILARITY: Belongs to the chaperonin (HSP60) family.


FUNCTION: May act as a co-chaperone for HSP90AB1 (By similarity). SUBCELLULAR LOCATION: Nucleus Nucleus, nucleoplasm Cytoplasm Note=Predominantly nuclear in the G1 and S phases of cell cycle and is evenly distributed between the nucleus and cytoplasm in the G2 phase (PubMed:19390865). MSL1 can promote its nuclear localization (PubMed:19390865, PubMed:24913909). SIMILARITY: Belongs to the TTC4 family.


FUNCTION: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. SUBCELLULAR LOCATION: Cell projection, pseudopodium. Cytoplasm, cytoskeleton.


FUNCTION: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the RNase PH family. Rrp41 subfamily.


FUNCTION: Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein Endomembrane system; Single-pass membrane protein Cytoplasm, perinuclear region Note=Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation. SIMILARITY: Belongs to the CD225/Dispanin family.


FUNCTION: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:23532839). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (PubMed:23872594). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein Note=Shows an intracellular localization. SIMILARITY: Belongs to the anoctamin family.


FUNCTION: Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner. FUNCTION: Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the Fur family.


SUBCELLULAR LOCATION: Mitochondrion matrix. SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family.


FUNCTION: Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid- containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (PubMed:8995428, PubMed:9298990). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides (PubMed:17640868). In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides (PubMed:17640868). In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides (PubMed:19367338). Inhibits axon longitudinal growth (PubMed:9298990). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid (PubMed:8995428). Binds ganglioside Gt1b (PubMed:8995428). SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein Membrane raft. SIMILARITY: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.


FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:18805096). This protein recognizes and binds the 7- methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (By similarity). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (By similarity). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:18805096, PubMed:25456498). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (PubMed:18805096). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (PubMed:25456498). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (By similarity). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine- containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures PubMed:7939721. Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (By similarity). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:8558852). Component of the CYFIP1- EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (By similarity). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (PubMed:8558852). SUBCELLULAR LOCATION: Cytoplasm, P-body Cytoplasm Cytoplasm, Stress granule Nucleus Note=Interaction with EIF4ENIF1/4E-T is required for localization to processing bodies (P-bodies). Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism. SUBCELLULAR LOCATION: Cytoplasm, P-body Cytoplasm Cytoplasm, Stress granule Nucleus Note=Interaction with EIF4ENIF1/4E-T is required for localization to processing bodies (P-bodies). Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism. SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.


FUNCTION: NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers. SIMILARITY: Belongs to the LysR transcriptional regulatory family.


FUNCTION: Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta- monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D- glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-triglucosyl-DAG (3-O- (beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl-beta-(1->6)-D- glucopyranosyl)-1,2-diacyl-sn-glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA). SUBCELLULAR LOCATION: Cell membrane. SIMILARITY: Belongs to the glycosyltransferase 28 family. UgtP subfamily.


FUNCTION: A 'suicide' enzyme that participates in biotin synthesis. Catalyzes the formation of (S)-8-amino-7-oxononanoate (DAN-carbamic acid) from (7R,8S)-8-amino-7-(carboxyamino)nonanoate (DAN), a function equivalent to the cannonical BioA reaction and the first half-reaction of BioD. The cellular requirement for biotin is thought be low enough that this single turnover enzyme supplies a sufficient amount of the cofactor. Overall it catalyzes three reactions: formation of a covalent linkage with 8-amino-7-oxononanoate to yield a BioU-DAN conjugate at the epsilon-amino group of Lys124 of BioU using NAD(P)H, carboxylation of the conjugate to form BioU-DAN-carbamic acid, and release of DAN- carbamic acid using NAD(P)+ (By similarity). Complements a bioA deletion in E.coli (PubMed:32042199). SIMILARITY: Belongs to the BioU family.


FUNCTION: Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs to which the M1 protein is bound. Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enters the cytoplasm only when they have associated with the M1 protein that is necessary to guide them to the plasma membrane. May down- regulate viral RNA synthesis when overproduced (By similarity). SUBCELLULAR LOCATION: Virion Host nucleus.


FUNCTION: Self-incompatibility (SI) is the inherited ability of a flowering plant to prevent self-fertilization by discriminating between self and non-self pollen during pollination. In many species of the Solanaceae, self-incompatibility is controlled by the single, multiallelic locus S. This stylar glycoprotein is associated with expression of self-incompatibility in potato. SUBCELLULAR LOCATION: Secreted, extracellular space. SIMILARITY: Belongs to the RNase T2 family.


FUNCTION: Potassium channel inhibitor (Kv). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor kappa-KTx family. Kappa-KTx 3 subfamily.


FUNCTION: Non-functional DHOase. SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. PyrC' subfamily.


FUNCTION: Squalene cyclase that catalyzes the oxygen-independent cyclization of squalene into hopanoids, a class of cyclic triterpenoids including hop-22(29)-ene, hop-17(21)-ene, hop-21(22)-ene, and hopan-22- ol. SIMILARITY: Belongs to the terpene cyclase/mutase family.


FUNCTION: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. SIMILARITY: Belongs to the RlpA family.


FUNCTION: Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position. SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. SIMILARITY: Belongs to the peptidase S1 family.


FUNCTION: Rod-core linker protein required for attachment of phycocyanin to allophycocyanin in cores of phycobilisomes. FUNCTION: Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer. SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. SIMILARITY: Belongs to the phycobilisome linker protein family.


FUNCTION: Gibberellin-regulated protein that may function in hormonal controlled steps of development such as seed germination, flowering and seed maturation. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the GASA family.


FUNCTION: Nitrilase that hydrolyzes preferentially phenylacetonitrile, (R,S)-mandelonitrile, and 3-indolylacetonitrile. SIMILARITY: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.


FUNCTION: Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the TGF-beta family.


FUNCTION: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity). SIMILARITY: Belongs to the SbcD family.


FUNCTION: Required for anther development and early tapetal function during microspore maturation (PubMed:18397379, PubMed:21957980). Regulates callose dissolution required for microspores release from the tetrads (PubMed:18397379). SUBCELLULAR LOCATION: Nucleus.


SIMILARITY: Belongs to the snRNP Sm proteins family.


FUNCTION: Possible metal-dependent hydrolase. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the metal hydrolase YfiT family.


FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. SUBCELLULAR LOCATION: Nucleus Chromosome, centromere, kinetochore Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore (By similarity). SIMILARITY: Belongs to the NUF2 family.


SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.


FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.


FUNCTION: Amphipathic peptide that shows no antibacterial activity even at 50 uM but shows a low hemolytic activity against human erythrocytes. SUBCELLULAR LOCATION: Secreted Target cell membrane Note=Forms a helical membrane channel in the prey. SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.


FUNCTION: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes. SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the DHHC palmitoyltransferase family.


FUNCTION: Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, cilium basal body Note=Associates with the mother centriole in early interphase. Localizes to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase. Localizes slightly apical to the subdistal appendage on the mother centriole, but below the distal appendage. SIMILARITY: Belongs to the CEP19 family.


FUNCTION: Mediates the splicing of pre-mRNA by binding to the stem loop I region of U1-snRNA (PubMed:15611175). Required during oogenesis for nurse cell chromatin dispersal (PubMed:24244416). SUBCELLULAR LOCATION: Nucleus speckle Nucleus, nucleoplasm.


FUNCTION: Plays a critical role in endothelial cell capillary morphogenesis. SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells. SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. SUBCELLULAR LOCATION: Secreted. SUBCELLULAR LOCATION: [Isoform 3]: Secreted. SUBCELLULAR LOCATION: [Isoform 2]: Secreted. SIMILARITY: Belongs to the plexin family.


FUNCTION: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein Note=Membrane-bound form in trans cisternae of Golgi. SIMILARITY: Belongs to the glycosyltransferase 23 family.


FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity). FUNCTION: Factor that activates expression from a metal response element of the mouse metallothionein-I gene. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.


FUNCTION: Efflux pump that contributes to intrinsic antibiotic resistance (PubMed:9811639, PubMed:12520088, PubMed:20525733, PubMed:30837962). The pump uses the electrochemical gradient as a source of energy (By similarity). Confers resistance to rifampicin (PubMed:20525733). Confers low-level resistance to tetracycline and to several aminoglycosides, including streptomycin, gentamicin, 2'-N- ethylnetilmicin and 6'-N-ethylnetilmicin (PubMed:9811639, PubMed:12520088). FUNCTION: Efflux pump that contributes to intrinsic antibiotic resistance. The pump uses the electrochemical gradient as a source of energy. FUNCTION: Efflux pump that contributes to intrinsic antibiotic resistance. The pump uses the electrochemical gradient as a source of energy. Confers resistance to various antibiotics, including tetracycline, acriflavine, spectinomycin and p-aminosalicylate. May be involved in export of toxic by-products that accumulate during stationary phase when nutrients are limited. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the major facilitator superfamily. Drug:H(+) antiporter-3 (DHA3) (TC 2.A.1.21) family.


SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the COE family.


FUNCTION: Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. SIMILARITY: Belongs to the RGI1 family.


FUNCTION: Participates in both transcription termination and antitermination. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the NusA family.


FUNCTION: Catalyzes the NADPH-dependent reduction of glyoxylate to glycolate as well as succinic semialdehyde (SSA) to gamma- hydroxybutyrate in vitro. May function in redox homeostasis and play a role in oxidative stress tolerance by detoxifying glyoxylate and SSA generated in glycolate metabolism and GABA metabolism, respectively. SUBCELLULAR LOCATION: Cytoplasm, cytosol Note=According to PubMed:22309191, GLYR1 does not localize in the peroxisome as initially described in PubMed:18495639. SIMILARITY: Belongs to the HIBADH-related family. NP60 subfamily.


FUNCTION: Negatively controls the transcription of the yiaKLMNOPQRS operon, which may be involved in the utilization of 2,3-diketo-L- gulonate.


FUNCTION: Acts as central component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters. The association of CBF3C with CBF3D and SGT1 is required for CBF3C activation and CBF3 assembly. SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere.


FUNCTION: Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (By similarity). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (By similarity). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (By similarity). SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein Nucleus Mitochondrion inner membrane; Single- pass membrane protein.


FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1. Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity). SUBCELLULAR LOCATION: Cytoplasm Nucleus Nucleus speckle Note=Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. SIMILARITY: Belongs to the PIAS family.


FUNCTION: May have antimicrobial activity. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the YARP (YGGW-amide related peptide) family.


FUNCTION: The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low. FUNCTION: Involved in 1,2-propanediol (1,2-PD) utilization in the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. Also able to catalyze the reverse reaction. Also has phosphate acetyltransferase activity to a lesser extent (PubMed:17158662). Required for optimal growth on 1,2-PD when the BMC is intact. CoA is regenerated within the BMC (for use by PduP) via this enzyme, although there must also be cofactor transport across the BMC. Directly targeted to the BMC (PubMed:25962918). SUBCELLULAR LOCATION: Bacterial microcompartment Note=Probably located inside the BMC shell. SIMILARITY: Belongs to the PduL family.


SIMILARITY: To M.genitalium MG385. SIMILARITY: To glycerophosphoryl diester phosphodiesterases (EC 3.1.4.46).


FUNCTION: Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. SIMILARITY: Belongs to the ROK (NagC/XylR) family. NagK subfamily.


SUBCELLULAR LOCATION: Plastid, chloroplast. SIMILARITY: Belongs to the ycf68 family.


FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub- subfamily.


FUNCTION: Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein Cell membrane Cytoplasm, perinuclear region Endoplasmic reticulum.


FUNCTION: Catalyzes a reversible epimerization of GDP-D-mannose that precedes the committed step in the biosynthesis of vitamin C (L- ascorbate), resulting in the hydrolysis of the highly energetic glycosyl-pyrophosphoryl linkage. Able to catalyze 2 distinct epimerization reactions and can release both GDP-L-galactose and GDP-L- gulose from GDP-mannose. SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase family.


FUNCTION: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type III membrane protein. SIMILARITY: Belongs to the PIGX family.


FUNCTION: Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (PubMed:19646955). Histone methyltransferase activity has not been confirmed in other species. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (PubMed:19646955). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (PubMed:22284184). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (PubMed:26023183). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase superfamily.


FUNCTION: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. May also mediate transport from the endoplasmic reticulum to the Golgi. SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein Endosome membrane; Single-pass type I membrane protein Endoplasmic reticulum membrane; Single-pass type I membrane protein Nucleus membrane; Single-pass type I membrane protein Cell membrane; Single-pass type I membrane protein; Extracellular side Lysosome membrane; Single-pass type I membrane protein. SIMILARITY: Belongs to the VPS10-related sortilin family. SORT1 subfamily.


FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the Mediator complex subunit 28 family.


FUNCTION: Plays a role in the inhibition of methylation at the GATC1028 site located in the regulatory region upstream of the pabA promoter. May, in conjunction with the Mbf (methylation blocking factor), inhibits deoxyadenosine methylase from methylating the GATC1028 site. SIMILARITY: To E.coli AfaF and DaaF.


SIMILARITY: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.


SIMILARITY: Belongs to the dGTPase family. Type 3 subfamily.


FUNCTION: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the UppP family.


FUNCTION: Couples the hydrolysis of ATP with the export of cadmium (PubMed:1530844). Involved in cadmium resistance (PubMed:2524829, PubMed:1530844). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.


FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the eukaryotic ribosomal protein eS28 family.


SIMILARITY: Belongs to the FAM53 family.


FUNCTION: Flavonol-specific transcription activator involved in the regulation of several genes of flavonoid biosynthesis. Activates the expression of CHS, CHI, F3H and FLS1. Controls flavonol biosynthesis primarily in cotyledons and leaves (PubMed:17419845, PubMed:20731781). Confers tolerance to UV-B (PubMed:19895401). SUBCELLULAR LOCATION: Nucleus.


FUNCTION: Essential for the functional mitochondria and respiratory growth. SUBCELLULAR LOCATION: Mitochondrion.


FUNCTION: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.


FUNCTION: Copper chaperone for cytochrome c oxidase (COX). Binds 2 copper ions and delivers them to the Cu(A) site of COX (By similarity). Can complement the yeast mutant cox17. SUBCELLULAR LOCATION: Mitochondrion intermembrane space. SIMILARITY: Belongs to the COX17 family.


FUNCTION: Involved in the export of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the ABC transporter superfamily. Cyclolysin exporter (TC 3.A.1.109.2) family.


FUNCTION: [FasL intracellular domain]: Cytoplasmic form induces gene transcription inhibition. FUNCTION: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:7511063). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:19794494, PubMed:7532682). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (PubMed:19794494). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (PubMed:10779162). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (By similarity). FUNCTION: [Tumor necrosis factor ligand superfamily member 6, soluble form]: Induces FAS-mediated activation of NF-kappa-B, initiating non- apoptotic signaling pathways (PubMed:19794494). Can induce apoptosis but does not appear to be essential for this process (By similarity). SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted Note=May be released into the extracellular fluid by cleavage from the cell surface. SUBCELLULAR LOCATION: [Isoform FasL]: Cell membrane; Single-pass type II membrane protein Cytoplasmic vesicle lumen Lysosome lumen Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane. SUBCELLULAR LOCATION: [FasL intracellular domain]: Nucleus Note=The FasL ICD cytoplasmic form is translocated into the nucleus. SIMILARITY: Belongs to the tumor necrosis factor family.


FUNCTION: Receptor for the netrin NTN4 that promotes neuronal cell survival (PubMed:21216843). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration (By similarity). Plays a role in the regulation of neuronal cell migration in the developing brain via its interaction with FLRT2 (PubMed:21673655). Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:21673655). May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (PubMed:26235030). SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. SIMILARITY: Belongs to the unc-5 family.


FUNCTION: Transcriptional repressor that constitutively blocks expression of beta-lactamase. Binds DNA as a dimer (By similarity). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the BlaI transcriptional regulatory family.


FUNCTION: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). Involved in acrosomal reaction (Probable). May also play a role in smooth muscle cells migration (PubMed:15721306). SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein Cytoplasmic vesicle, secretory vesicle, acrosome membrane Note=Absent from the sperm flagellum. SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.


FUNCTION: Activates HIS4 transcription only in combination with PHO2/BAS2. BAS1 is also involved in the regulation of the purine biosynthesis pathway. SUBCELLULAR LOCATION: Nucleus.


FUNCTION: Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co- infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication (By similarity). SUBCELLULAR LOCATION: Virion. Host nucleus, host nucleolus. Note=isoprenylated in the cytoplasm, and translocates in the nucleus possibly after phosphorylation. Translocates after to nuclear speckle, then to the ER membrane where interaction with Hepatitis B virus antigene takes place (By similarity). SIMILARITY: Belongs to the hepatitis delta antigen family.


FUNCTION: Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the cytochrome b family.


FUNCTION: Late protein which is part of a large complex required for early virion morphogenesis. This complex participates in the formation of virosomes and the incorporation of virosomal contents into nascent immature virions. SUBCELLULAR LOCATION: Virion Note=Localizes to the virion core. SIMILARITY: Belongs to the orthopoxvirus OPG115 family.


FUNCTION: FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of sorbicillinoids, a diverse group of yellow secondary metabolites that restrict growth of competing pathogenic fungi but not of bacteria (PubMed:25580210, PubMed:28618182). Sorbicillinoids biosynthesis requires the action of two PKSs (PubMed:25580210). SorA iteratively combines three acetyl units and the growing chain is modified by the ketoacyl reductase subunit, and optional by the enoyl reductase subunit in the second cycle (PubMed:25580210). The polyketide is then handed over to the PKS SorB, which adds three more acetyl units, and two methyl groups (PubMed:25580210). SorB releases an aldehyde, which undergoes spontaneous cyclization resulting in the formation of sorbicillin or 2',3'-dihydrosorbicillin (PubMed:25580210). The monooxygenase sorC oxidizes sorbicillin and 2',3'-dihydrosorbicillin to 2',3'- dihydrosorbicillinol and sorbicillinol, respectively (PubMed:28618182). The oxidoreductase sorD further converts sorbicillinol into oxosorbicillinol (PubMed:28618182). Sorbicillinol is the building block for the other sorbicillinoids such as disorbicillinol, bisvertinolon, and dihydrobisvertinolone (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein. SIMILARITY: Belongs to the paxM FAD-dependent monooxygenase family.


FUNCTION: The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. SIMILARITY: Belongs to the enterotoxin A family.


FUNCTION: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity). FUNCTION: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. SIMILARITY: Belongs to the universal ribosomal protein uL1 family.


FUNCTION: Catalytic subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Negatively regulates full-length ci stability and hedgehog signaling. SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.


FUNCTION: Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the activator element (AE) motif of the selenocysteine tRNA gene promoter (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.


FUNCTION: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region Cytoplasm, cytoskeleton. SIMILARITY: Belongs to the MAP7 family.


FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the Mediator complex subunit 1 family.


FUNCTION: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the myelin proteolipid protein family.


FUNCTION: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Also functions as a metastasis suppressor gene in prostate cancer (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.


SUBCELLULAR LOCATION: Mitochondrion matrix. SIMILARITY: Belongs to the aldehyde dehydrogenase family.


FUNCTION: Structural protein that forms a matrix surrounding the mature virion (MV) through interaction with protein A26. Presence of protein A25 in the virion structurally prevents direct virus-cell fusion mechanism (By similarity). SUBCELLULAR LOCATION: Virion. Note=Present above the membrane of mature virions (MV). SIMILARITY: Belongs to the poxviridae A25 protein family.


FUNCTION: Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon (By similarity). SUBCELLULAR LOCATION: Cytoplasm.


SIMILARITY: Belongs to the ADP-ribosylglycohydrolase family.


SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: To E.coli YhdT.


SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.


FUNCTION: May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.


FUNCTION: The outer membrane component of an organic solvent efflux pump. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon expression level. FUNCTION: The outer membrane component of an organic solvent efflux pump. Involved in export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can export AMP and some antibiotics. SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor. SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.


FUNCTION: Plays a role as a transcriptional activator or repressor (PubMed:14671321). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the distal-less homeobox family.


FUNCTION: Catalyzes the transfer of the amino group from gamma- aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semialdehyde (SSA). PuuE is important for utilization of putrescine as the sole nitrogen or carbon source. SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


FUNCTION: Promotes simple nitriles, but not epithionitrile or thiocyanate formation (PubMed:18987211, PubMed:19224919). Converts allylglucosinolate and benzylglucosinolate to their corresponding simple nitriles in the presence of myrosinase (PubMed:18987211, PubMed:19224919). Triggers the production 3-butenylnitrile (PubMed:19224919). SIMILARITY: Belongs to the jacalin lectin family.


FUNCTION: Required for mitotic fidelity, specifically in the G2 phase of the cell cycle. Plays a role in chromatin organization.


FUNCTION: Involved in the binding and/or turnover of quinones at the Q(B) site of Photosystem II. SUBCELLULAR LOCATION: Cellular thylakoid membrane; Single-pass membrane protein. SIMILARITY: Belongs to the PsbX family. Type 2 subfamily.


FUNCTION: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. SUBCELLULAR LOCATION: Mitochondrion intermembrane space. SIMILARITY: Belongs to the adenylate kinase family. AK2 subfamily.


FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell, into the endoplasmic reticulum, or into organelles. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.


FUNCTION: Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators. SUBCELLULAR LOCATION: Nucleus, nucleolus. SIMILARITY: Belongs to the MBF1 family.


FUNCTION: Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome. SUBCELLULAR LOCATION: Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.


FUNCTION: inhibits Kv1.3/KCNA3 channel. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 30 subfamily.


FUNCTION: A P subtype restriction enzyme that recognizes the double- stranded sequence 5'-CCNGG-3' and cleaves after C-2.


FUNCTION: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. SIMILARITY: Belongs to the glycosyltransferase 26 family.


FUNCTION: Antibacterial protein involved in the immune response to septic injury. When combined with 14.026 kDa and 14.059 kDa hemolymph antimicrobial peptides, it has a strong cooperative activity against the Gram-positive bacteria B.subtilis and S.aureus, and against the Gram-negative bacteria E.coli DH5-alpha and K.pneumoniae ATCC 138833. Does not show detectable antibacterial activity when present alone. Has no hemolytic activity in human erythrocytes. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the invertebrate defensin family.


FUNCTION: Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the FlhC family.


FUNCTION: Specifically methylates guanosine-37 in various tRNAs. FUNCTION: Specifically methylates guanosine-37 in various tRNAs. SUBCELLULAR LOCATION: Cytoplasm. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the RNA methyltransferase TrmD family. SIMILARITY: Belongs to the RNA methyltransferase TrmD family.


FUNCTION: Probable cyclic nucleotide-gated ion channel. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.


FUNCTION: Intercellular signal essential for a variety of patterning events during development. SUBCELLULAR LOCATION: Secreted.


FUNCTION: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release (By similarity). SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the glutaredoxin family.


FUNCTION: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). SIMILARITY: Belongs to the polypeptide deformylase family.


FUNCTION: May be involved in the assemblage of active methanol dehydrogenase and/or its cofactor PQQ in the periplasm. SUBCELLULAR LOCATION: Periplasm.


FUNCTION: Catalyzes the deimination of arginine residues of proteins (By similarity). In oocytes, is released during cortical reaction and plays a role in preimplantation cleavage and early embryonic development (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678). FUNCTION: Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678). SUBCELLULAR LOCATION: Cytoplasm Nucleus Cytoplasmic vesicle, secretory vesicle, Cortical granule Note=Predominantly cytoplasmic (oocyte cytoplasmic sheets), also nuclear. Released extracellularly during the cortical reaction, and remains associated with the blastomeres surfaces as a peripheral membrane protein until the blastocyst stage of development. SIMILARITY: Belongs to the protein arginine deiminase family.


FUNCTION: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling (PubMed:29123071). Acts as a sensor of S- adenosyl-L-methionine to signal methionine sufficiency to mTORC1 (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine- dependent methyltransferase. SIMILARITY: Belongs to the BMT2 family.


FUNCTION: May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein Membrane raft Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). SIMILARITY: Belongs to the caveolin family.


SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.


FUNCTION: Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha- chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins (PubMed:7360115, PubMed:17320177). Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces (PubMed:2141838, PubMed:9605165, PubMed:12055245). The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization (PubMed:28671664). SUBCELLULAR LOCATION: Secreted, extracellular space. Secreted. SIMILARITY: Belongs to the peptidase S1 family.


FUNCTION: Acts as GTPase-activating protein for RAB27A. SUBCELLULAR LOCATION: Cell projection, microvillus Note=Localizes to the microvilli-rich region of the syncytiotrophoblast.


SIMILARITY: Belongs to the UPF0273 family.


FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the conotoxin M superfamily.


SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the neurotoxin 02 (plectoxin) family. 07 subfamily.


FUNCTION: Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (By similarity). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (By similarity). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Binds to a consensus sequence in gene promoters (By similarity). Its target genes for transcriptional activation activity include: genes involved in anti- viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as GBP2, GBP5 and NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (By similarity). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (By similarity). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (By similarity). Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (By similarity). Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (By similarity). Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (By similarity). SUBCELLULAR LOCATION: Nucleus Cytoplasm Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1. SIMILARITY: Belongs to the IRF family.


FUNCTION: Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the sterol desaturase family.


SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the CTL (choline transporter-like) family.


FUNCTION: Antimicrobial peptide active against plant pathogenic fungi and Gram-negative and -positive bacteria.


FUNCTION: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor Note=Localizes at the septal ring. Is also associated with some other structures/complexes along the cell cylinder. SIMILARITY: Belongs to the RlpA family.


FUNCTION: Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:7657650). Binds copper ions (PubMed:7657650). SUBCELLULAR LOCATION: Cytoplasm Melanosome Nucleus Endoplasmic reticulum. SIMILARITY: Belongs to the adenosylhomocysteinase family.


FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity). SIMILARITY: Belongs to the complex I 75 kDa subunit family.


FUNCTION: Integral endoplasmic reticulum membrane protein that coordinates the assembly of the ER-associated protein degradation (ERAD) machinery at the ER membrane. Mediates binding of CDC48 to the E3 ubiquitin ligases SSM4/DOA10 and HRD1, and to ERAD substrates. Component of the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. ERAD-C substrates are ubiquitinated through DOA10 in conjunction with the E2 ubiquitin- conjugating enzymes UBC6 and UBC7-CUE1. Also a component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER- membrane proteins with misfolded transmembrane domains (ERAD-M). ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48- NPL4-UFD1 ATPase complex and targeted to the proteasome. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.


FUNCTION: Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the FAD-dependent oxidoreductase family.


FUNCTION: Alkaline phosphatase that can hydrolyze various phosphate compounds. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. SIMILARITY: Belongs to the alkaline phosphatase family.


FUNCTION: May be involved in sulfur metabolism and oxidative stress response. Does not show RuBisCO activity (By similarity). SIMILARITY: Belongs to the RuBisCO large chain family. Type IV subfamily.


FUNCTION: Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.


FUNCTION: Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation. SUBCELLULAR LOCATION: Cytoplasm Note=Septum.


FUNCTION: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity). Aminopeptidase that binds to the auxin transport inhibitor N-1- naphthylphthalamic acid (NPA). May play a negative role in the regulation of PIN auxin transport proteins (PubMed:11891249). SUBCELLULAR LOCATION: Cytoplasm Cell membrane; Peripheral membrane protein Microsome membrane; Peripheral membrane protein. SIMILARITY: Belongs to the peptidase M24B family.


SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.


SUBCELLULAR LOCATION: Plastid. SIMILARITY: Belongs to the universal ribosomal protein uL2 family.


FUNCTION: Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix Secreted. SIMILARITY: Belongs to the Wnt family.


FUNCTION: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. SIMILARITY: Belongs to the universal ribosomal protein uS12 family.


FUNCTION: Ribonucleoprotein DNA polymerase that catalyzes the de novo synthesis of telomeric simple sequence repeats. Subunit p95 contains some or all of the template-independent primer DNA-binding site termed the anchor site. SUBCELLULAR LOCATION: Nucleus Chromosome, telomere.


FUNCTION: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. SUBCELLULAR LOCATION: Cytoplasm, cytosol Nucleus. SIMILARITY: Belongs to the peptidase M1 family.


FUNCTION: Probable secreted regulatory protein. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the CCN family.


FUNCTION: Has a role in the perception of gravity.


FUNCTION: Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with HRT1/RBX1 to recruit the Nedd8-charged E2 UBC12 to the cullin component of SCF-type complexes.


FUNCTION: FAD-binding monooxygenase; part of the gene cluster that mediates the biosynthesis of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture (PubMed:27602587). The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase prhL (By similarity). Synthesis of DMOA is followed by farnesylation by the prenyltransferase prhE, methylesterification by the methyl-transferase prhM, epoxidation of the prenyl chain by the flavin-dependent monooxygenase prhF, and cyclization of the farnesyl moiety by the terpene cyclase prhH, to yield the tetracyclic intermediate, protoaustinoid A (By similarity). The short chain dehydrogenase prhI then oxidizes the C-3 alcohol group of the terpene cyclase product to transform protoaustinoid A into protoaustinoid B (PubMed:27602587). The FAD-binding monooxygenase prhJ catalyzes the oxidation of protoaustinoid B into preaustinoid A which is further oxidized into preaustinoid A1 by FAD-binding monooxygenase phrK (PubMed:27602587). Finally, prhA leads to berkeleydione via the berkeleyone B intermediate (PubMed:27602587, PubMed:29317628). PrhA is a multifunctional dioxygenase that first desaturates at C5-C6 to form berkeleyone B, followed by rearrangement of the A/B-ring to form the cycloheptadiene moiety in berkeleydione (PubMed:27602587, PubMed:29317628). Berkeleydione serves as the key intermediate for the biosynthesis of paraherquonin as well as many other meroterpenoids (Probable). The cytochrome P450 monooxygenases prhB, prhD, and prhN, as well as the isomerase prhC, are probably involved in the late stage of paraherquonin biosynthesis, after the production of berkeleydione (Probable). Especially prhC might be a multifunctional enzyme that catalyzes the D-ring expansion via intramolecular methoxy rearrangement, as well as the hydrolysis of the expanded D-ring (Probable). SIMILARITY: Belongs to the FAD-binding monooxygenase family.


FUNCTION: Serves two roles in transcription; it acts in concert with viral termination factor/capping enzyme to catalyze release of UUUUUNU- containing nascent RNA from the elongation complex, and it acts by itself as a polymerase elongation factor to facilitate readthrough of intrinsic pause sites. SIMILARITY: Belongs to the helicase family. NPH I subfamily.


FUNCTION: Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.


FUNCTION: Promotes colloidosmotic lysis by binding to the midgut epithelial cells of Coleoptera. SIMILARITY: Belongs to the delta endotoxin family.


FUNCTION: Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle (PubMed:1375450). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum Sarcoplasmic reticulum Sarcoplasmic reticulum lumen Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side Mitochondrion matrix Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells. In a minority of cells, homogeneously detected in the ER lumen. Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellular calcium. SIMILARITY: Belongs to the calsequestrin family.


SUBCELLULAR LOCATION: Cytoplasm Membrane; Multi-pass membrane protein.


FUNCTION: Part of the binding-protein-dependent transport system for glutamine. Probably responsible for energy coupling to the transport system. SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. SIMILARITY: Belongs to the ABC transporter superfamily.


FUNCTION: Plays a major role in antagonizing the type I IFN-mediated antiviral response. May also inhibit viral transcription and RNA replication (By similarity). SUBCELLULAR LOCATION: Host cytoplasm. SIMILARITY: Belongs to the pneumovirus non-structural protein 2 family.


FUNCTION: Envelope protein. SUBCELLULAR LOCATION: Virion membrane; Multi-pass membrane protein Note=Probably localizes to the membrane of mature virions (MV). SIMILARITY: Belongs to the orthopoxvirus OPG081 family.


FUNCTION: May regulate actin polymerization, filopodia dynamics and arborization of neurons. SUBCELLULAR LOCATION: Nucleus speckle Cell projection, lamellipodium Nucleus Cell projection, growth cone Cell projection, dendrite Note=Localizes to somata and dendrites in cortical neurons. SIMILARITY: Belongs to the ABITRAM family.


FUNCTION: Required for the in vivo function of penicillin-binding protein 2a (PBP2a), which is involved in the biosynthesis of cross- linked peptidoglycan (PG) of the cell wall. SUBCELLULAR LOCATION: Cell membrane; Single-pass type IV membrane protein Note=Localizes to sites of new peptidoglycan (PG) synthesis at midcell independently of PBP2a.


FUNCTION: Required for 3'-end cleavage and polyadenylation of pre- mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle. SUBCELLULAR LOCATION: Nucleus.


FUNCTION: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. May be important for freshwater adaptation. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the natriuretic peptide family.


FUNCTION: Probable transcription factor. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the HD-ZIP homeobox family. Class I subfamily.


FUNCTION: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase- 3/TMPRSS7 and chymotrypsin. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the serpin family.


SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the DeoC/FbaB aldolase family.


FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the CSN3 family.


FUNCTION: Acts as a negative regulator for calcification in the shells of mollusks. May function both as a calcium concentrator and as a carbonic anhydrase required for production of carbonate ions, which are assembled to CaCO(3) at mineralization sites. Is important for shell formation in both the calcitic prismatic layer and the aragonitic nacreous layer (By similarity). Shows inhibitory activity of crystal formation when present in free state but, when attached to the insoluble matrix, may regulate the form and size of aragonite crystal. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. SIMILARITY: Belongs to the alpha-carbonic anhydrase family.


FUNCTION: Involved in regulation of DNA replication. SIMILARITY: Belongs to the CDC6/cdc18 family.


FUNCTION: Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S- stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids. Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols. Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further metabolized by ALOX5 and LTA4H to generate 18S-RvE1 and 18S- RvE2. In vascular endothelial cells, converts docosapentaenoate (DPA, C22:5(n-3)) to 13R-HDPA, a precursor for 13-series resolvins (RvTs) shown to activate macrophage phagocytosis during bacterial infection. In activated leukocytes, contributes to oxygenation of hydroxyeicosatetraenoates (HETE) to diHETES (5,15-diHETE and 5,11- diHETE). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy- (10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)- octadecadienoate) its major products (By similarity). During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs) 15R-lipoxin A4 that regulates phagocytic microglia (By similarity). SUBCELLULAR LOCATION: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. SIMILARITY: Belongs to the prostaglandin G/H synthase family.


FUNCTION: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. SUBCELLULAR LOCATION: Mitochondrion Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. SIMILARITY: Belongs to the universal ribosomal protein uS15 family.


FUNCTION: Golgi membrane protein involved in vesicular trafficking. SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi- pass membrane protein. SIMILARITY: Belongs to the TVP18 family.


SUBCELLULAR LOCATION: Nucleus, nucleolus. SIMILARITY: Belongs to the PNO1 family.


FUNCTION: Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). May be involved in a degradation pathway of t4LHyp. Can also catalyze the epimerization of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp) in vitro, albeit with 2-fold lower efficiency. Displays no proline racemase activity. SIMILARITY: Belongs to the proline racemase family.


FUNCTION: Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 35-40 nm in diameter. SUBCELLULAR LOCATION: Virion.


FUNCTION: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser- 62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.


FUNCTION: Catalyzes the NADPH-dependent reductive deacylation of (S)-3- hydroxy-3-methylglutaryl-CoA (HMG-CoA) to (R)-mevalonate. Cannot use NADH instead of NADPH. Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the HMG-CoA reductase family.


FUNCTION: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.


FUNCTION: Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. SUBCELLULAR LOCATION: Endomembrane system; Multi-pass membrane protein Late endosome membrane Cell membrane Cell projection Lysosome membrane Endosome membrane Endosome, multivesicular body membrane Endosome, multivesicular body lumen. SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.


FUNCTION: Pycsar (pyrimidine cyclase system for antiphage resistance) provides immunity against bacteriophage. The pyrimidine cyclase (PycC) synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate the adjacent effector, leading to bacterial cell death and abortive phage infection. A clade D Pycsar system. FUNCTION: The effector gene of a two-gene Pycsar system. Expression of this and adjacent uridylate cyclase PtPycC (AC A0A4V2JTK3) probably confers resistance to bacteriophage. The genes are probably only expressed in response to bacteriophage infection. Probably only responds to cUMP (produced by its cognate NTP cyclase), acts by impairing membrane integrity. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.


FUNCTION: Hydrolyzes the cell wall of M.luteus more efficiently than that of B.licheniformis and B.subtilis. The C-terminal region, including the repeats, determines substrate specificity. SUBCELLULAR LOCATION: Secreted Note=Accumulates in cells as inclusion bodies. May be secreted by a mechanism different from the normal export system. SIMILARITY: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.


FUNCTION: Paternally sperm-supplied factor required for embryogenesis (PubMed:8565851, PubMed:20971008). Plays a role in preventing polyspermy possibly by promoting the formation of a continuous and cohesive eggshell chitin layer (PubMed:20971008). SUBCELLULAR LOCATION: Cytoplasm, perinuclear region Note=Localized to the perinuclear region of sperm.


FUNCTION: Involved in pyrimidine catabolism. May facilitate the hydrolysis of carbamate, a reaction that can also occur spontaneously. FUNCTION: Involved in pyrimidine catabolism (PubMed:16540542). May facilitate the hydrolysis of carbamate, a reaction that can also occur spontaneously (Probable). SIMILARITY: Belongs to the AB hydrolase superfamily. Hydrolase RutD family. SIMILARITY: Belongs to the AB hydrolase superfamily. Hydrolase RutD family.


FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the SMARCD family.


FUNCTION: Required for protein transport between the Golgi and the endoplasmic reticulum. May tether coatomer-coated retrograde transport vesicles to the ER membrane through interaction with coatomer as well as the SNARE complex. May contribute to the stabilization of the SNARE complex. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein.


FUNCTION: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the HSBP1 family.


FUNCTION: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass membrane protein.


FUNCTION: Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. SUBCELLULAR LOCATION: Cell projection, cilium Nucleus. SIMILARITY: Belongs to the CLUAP1 family.


FUNCTION: Probably involved in the biogenesis of the ribosome.


FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the complex I subunit 2 family.


FUNCTION: May play only a redundant role in maintaining cell wall viability and bacterial virulence. FUNCTION: May play only a redundant role in maintaining cell wall viability and bacterial virulence. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the glycosyltransferase 2 family.


FUNCTION: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. May play a role in the regulation of cell proliferation. SUBCELLULAR LOCATION: Secreted. Note=Dense core vesicles (DCV). SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.


FUNCTION: Putative RNA-binding protein. May be involved in regulating gene expression during embryonic development. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the BicC family.


SIMILARITY: Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.


FUNCTION: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer of 2- methyl-aconitate. It is also able to catalyze the dehydration of citrate and the hydration of cis-aconitate at a lower rate. Due to its broad substrate specificity, it seems to be responsible for the residual aconitase activity of the acnAB-null mutant. SIMILARITY: Belongs to the PrpD family.


FUNCTION: Exhibits a non sequence-specific DNA-binding activity. SIMILARITY: Belongs to the remorin family.


FUNCTION: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the sesterterpenes ophiobolins, fungal phytotoxins with potential anti-cancer activities (PubMed:23324037, PubMed:27116000). The first step of the pathway is performed by the sesterterpene synthase oblA that possesses both prenyl transferase and terpene cyclase activity, converting isopentenyl diphosphate and dimethylallyl diphosphate into geranylfarnesyl diphosphate (GFPP) and further converting GFPP into ophiobolin F, respectively (PubMed:23324037). Other sesterterpenoids (C(25) terpenoids) are found as minor products of oblA (PubMed:23324037). It is expected that ophiobolin F is then oxidized to ophiobolin A via ophiobolin C and ophiobolin B intermediates by the combined action of the cytochrome P450 monooxygenase oblB and the FAD-dependent oxidoreductase oblC (Probable). Although oblB catalyzes multistep oxygenations at C5 and C21/C7 in a relatively efficient manner, it is unable to convert ophiobolin F to ophiobolin C and produces instead several unexpected derivatives (PubMed:27116000). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the cytochrome P450 family.


FUNCTION: May have a role in hematopoietic cell differentiation. SUBCELLULAR LOCATION: Secreted.


FUNCTION: Regulates the expression of extracellular-protein genes of Bacillus natto. SIMILARITY: To B.subtilis SenS.


FUNCTION: ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.


SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.


SUBCELLULAR LOCATION: Nucleus Cytoplasm Note=Present in the germ cell lineage at all stages (PubMed:26168773).


FUNCTION: Required for specific RNA editing events in chloroplasts and stabilizes specific chloroplast mRNAs (PubMed:19297624). SUBCELLULAR LOCATION: Plastid, chloroplast.


FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.


SUBCELLULAR LOCATION: Plastid, chloroplast. SIMILARITY: Belongs to the TrpF family.


FUNCTION: S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.