FUNCTION: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha- amino group of the newly exposed N-terminal phenylalanine. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the peptidase A24 family.


FUNCTION: Antimicrobial peptide active at least against the Gram- positive bacterium S.aureus but with otherwise unclear activity spectrum (PubMed:16487561, PubMed:16621155). Lacks hemolytic activity against rabbit or human erythrocytes (PubMed:16487561, PubMed:16621155). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.


FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). SUBCELLULAR LOCATION: Nucleus.


FUNCTION: Involved in the formation of 2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase. SIMILARITY: Belongs to the CitG/MdcB family.


FUNCTION: Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE- containing ligands as well as clusterin/CLU. In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (By similarity). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.


FUNCTION: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification (By similarity). SUBCELLULAR LOCATION: Nucleus Chromosome, telomere. SIMILARITY: Belongs to the CGI121/TPRKB family.


FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.


FUNCTION: Catalyzes endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan with retention of the beta-configuration of the glycosyl residues. Specific for xyloglucan and does not hydrolyze other cell wall components (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the glycosyl hydrolase 12 (cellulase H) family.


FUNCTION: Involved in polyamine biosynthesis. SIMILARITY: Belongs to the carbon-nitrogen hydrolase superfamily.


FUNCTION: Involved in arsenical resistance. Thought to form the channel of an arsenite pump. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the ArsB family.


SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the neurotoxin 19 (CSTX) family. 02 (D7) subfamily.


SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the MAL family.


FUNCTION: Interacts with VP7 to form the outer icosahedral capsid with an incomplete T=13 symmetry, about 80 nm in diameter, and consisting of 200 VP4-VP7 trimers. Myristoylated N-terminal peptide may be released in the endosome and involved in permeabilization and delivery of transcriptionally active viral particles into the host cell cytoplasm (Potential). SUBCELLULAR LOCATION: Virion. SIMILARITY: Belongs to the aquareoviridae outer capsid VP4 protein family.


FUNCTION: Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. Connects the central plaque of the SPB with the half-bridge. Required for proper localization of CDC5 at the SPB and for proper M-phase progression (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body Note=Associates with the periphary of the central plaque. SIMILARITY: Belongs to the BBP1 family.


FUNCTION: Reversibly blocks voltage-gated potassium channels (Kv1.1/KCNA1 (Kd=79 uM), Kv1.2/KCNA2 (Kd=547 nM) and Kv1.3/KCNA3 (Kd=492 nM)). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 01 subfamily.


FUNCTION: RNA-binding protein interacting with the enod40 RNA. SUBCELLULAR LOCATION: Nucleus speckle Cytoplasmic granule Note=Exported into cytoplasmic granules during nodule development (PubMed:15037734). Relocalizes to cytoplasmic granules when associated with enod40 RNA (PubMed:15037734).


FUNCTION: Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool (By similarity). SUBCELLULAR LOCATION: Mitochondrion matrix. SIMILARITY: Belongs to the complex I LYR family. MZM1 subfamily.


FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. SIMILARITY: Belongs to the SINA (Seven in absentia) family.


FUNCTION: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function (By similarity). SUBCELLULAR LOCATION: Cytoplasm, perinuclear region Membrane; Peripheral membrane protein Membrane; Lipid-anchor Postsynaptic density Synapse, synaptosome Cytoplasm, cytoskeleton Note=Also membrane-associated, present at excitatory synapses.


FUNCTION: May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the pICln (TC 1.A.47) family.


FUNCTION: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. SUBCELLULAR LOCATION: Cytoplasm, cytosol Secreted Lysosome Secreted, extracellular exosome Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10. SIMILARITY: Belongs to the IL-1 family.


FUNCTION: In its hexameric form, promotes the accumulation of sec-16A.1 and the COPII subunit npp-20 at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER), to positively regulate secretory cargo trafficking from the endoplasmic reticulum to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and Golgi apparatus (PubMed:21478858). Required for the assembly of proteins, such as the GTPase rab-6, at the Golgi apparatus (PubMed:21478858). Plays a role in negatively regulating cell death and promoting cell and body growth (PubMed:18635357). SUBCELLULAR LOCATION: Endoplasmic reticulum Endoplasmic reticulum-Golgi intermediate compartment Mitochondrion Note=In oocytes, co-localizes with sec- 16A.1 at endoplasmic reticulum exit sites (ERES) (PubMed:21478858). In proximal oocytes, localizes to a cloud-like region at endoplasmic reticulum exit sites that spreads to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (PubMed:21478858).


FUNCTION: Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (By similarity). It cleaves after Asp (PubMed:9765264). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (By similarity). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution (By similarity). Cleaves caspase-3 and -9 (CASP3 and CASP9, respectively) to give rise to active enzymes mediating apoptosis (PubMed:9765264). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (By similarity). SUBCELLULAR LOCATION: Secreted Cytolytic granule Note=Delivered into the target cell by perforin. SIMILARITY: Belongs to the peptidase S1 family. Granzyme subfamily.


FUNCTION: Plays a role in cuticle calcification. May induce precipitation of the calcium stored in the posterior caeca as calcium carbonate. SUBCELLULAR LOCATION: Secreted Note=During the premolt period, localizes to microvilli-rich apical regions and to the subnuclear region. During the postmolt period, localizes to the intercellular space, basal region of cells and calcium reabsorption spherules.


FUNCTION: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4). SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region.


FUNCTION: May be involved in pre-mRNA splicing. SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the CWC22 family.


FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein Late endosome membrane; Single-pass type IV membrane protein Lysosome membrane; Single-pass type IV membrane protein Endoplasmic reticulum membrane; Single-pass type IV membrane protein Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein Note=During macropinocytosis highest levels are found in endosomes with lower levels observed in the lysosomes. SIMILARITY: Belongs to the synaptobrevin family.


FUNCTION: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the NCF2/NOXA1 family.


FUNCTION: Probable sterol desaturase. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the sterol desaturase family.


FUNCTION: Essential for all lupin cells independent of the respective tissue. SUBCELLULAR LOCATION: Nucleus.


SIMILARITY: Belongs to the mgp1/MG371 family.


SIMILARITY: Belongs to the MgpC family.


FUNCTION: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the Fur family.


FUNCTION: Inulin-specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes.


FUNCTION: Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme-A to the apo-[acyl-carrier-protein] of the malonate decarboxylase to yield holo-[acyl-carrier-protein]. SIMILARITY: Belongs to the MdcG family.


FUNCTION: Involved in pre-mRNA splicing and required for cell cycle progression at G2/M. SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family.


FUNCTION: Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). FUNCTION: Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.


FUNCTION: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). Can only oxidize formylmethanofuran. This enzyme is oxygen-labile. SIMILARITY: In the C-terminal section; belongs to the molybdenum dinucleotide binding protein family. SIMILARITY: In the N-terminal section; belongs to the FwdC/FmdC family.


FUNCTION: Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position (PubMed:11278902). Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein Secreted Note=Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.


FUNCTION: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Carries out the first step of the leucine biosynthesis pathway. Also displays a low citramalate synthase activity, using pyruvate as substrate, but is unable to use 2-oxoglutarate. SIMILARITY: Belongs to the alpha-IPM synthase/homocitrate synthase family.


FUNCTION: Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. SIMILARITY: Belongs to the small Tim family.


FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the Mediator complex subunit 27 family.


FUNCTION: Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. SIMILARITY: Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein oxidoreductase family.


FUNCTION: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.


FUNCTION: Has bactericidal activity (By similarity). May play a role in the antimicrobial protection of sperm and urogenital tract epithelia (PubMed:16023745). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the beta-defensin family.


FUNCTION: Brassicaceae-specific phytocytokine (plant endogenous peptide released into the apoplast) perceived by MIK2 in a BAK1/SERK3 and SERK4 coreceptors-dependent manner, that modulates various physiological and antimicrobial processes including growth prevention and reactive oxygen species (ROS) response regulation (PubMed:33514716, PubMed:34535661, PubMed:31001913). Promotes the expression of immune-related marker genes (e.g. WRKY30, WRKY33 and CYP81F2) in a MIK2-dependent manner (PubMed:34535661). Inhibits root growth and regulates root meristems (PubMed:34535661, PubMed:31001913). Prevents general growth and development (PubMed:31001913). Exhibits antibacterial effects against Pseudomonas syringae pv. tomato DC3000, Ralstonia solanacearum, Bacillus subtilis and Agrobacterium tumefaciens, thus being an antimicrobial peptide (AMP) (PubMed:31001913). SUBCELLULAR LOCATION: Cell membrane Secreted, extracellular space, apoplast Note=The precursor of SCOOP13, PROSCOOP13, accumulates at the plasma membrane and is proteolytically cleaved to release the SCOOP13 in the apoplasm. SIMILARITY: Belongs to the serine rich endogenous peptide (SCOOP) phytocytokine family.


FUNCTION: Acts as a translational repressor of viral replicase synthesis late in infection. This latter function is the result of capsid protein interaction with an RNA hairpin which contains the replicase ribosome-binding site. FUNCTION: Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 26 nm in diameter, and consisting of 89 capsid proteins dimers (178 capsid proteins). Involved in viral genome encapsidation through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome. Binding of the capsid proteins to the viral RNA induces a conformational change required for efficient T=3 shell formation. The capsid contains also 1 copy of the A2 maturation protein. SUBCELLULAR LOCATION: Virion Note=The shell is composed of 89 dimers of the capsid protein and 1 copy of the maturation protein. SIMILARITY: Belongs to the Leviviricetes capsid protein family.


FUNCTION: Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.


FUNCTION: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the AAA ATPase family.


FUNCTION: Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn, Met-Gln or Met-Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions, it is presumed to N-acetylate 15% of all yeast proteins. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the acetyltransferase family. GNAT subfamily.


FUNCTION: Probable ion channel inhibitor. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the neurotoxin 14 (magi-1) family. 01 (HNTX-16) subfamily.


FUNCTION: Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX (By similarity). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (By similarity). SUBCELLULAR LOCATION: Cytoplasm Nucleus, nucleoplasm Nucleus, PML body Nucleus, nucleolus Chromosome, centromere Note=Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli. Colocalizes with histone H3.3, ATRX, HIRA and ASF1A at PML-nuclear bodies. Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres. Detected in cytoplasmic punctate structures. Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress. Colocalizes with RASSF1 in the nucleus. Colocalizes with USP7 in nucleoplasma with accumulation in speckled structures. SIMILARITY: Belongs to the DAXX family.


FUNCTION: May be involved in a proteolytic pathway controlling the nuclear division phase of megagametogenesis. SUBCELLULAR LOCATION: Secreted Note=Prediction of a peroxisomal location. SIMILARITY: Belongs to the peptidase S28 family.


FUNCTION: Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). During development, is required for heart looping and swim bladder formation by acting in concert with GATA4 and ZFPM1 (PubMed:23836893). During the development of both the retina and skeletal muscles is required for neural retinal cell through modulating PAX6 and NEUROG3 expression and myogenic differentiation (PubMed:20532172). SUBCELLULAR LOCATION: Nucleus Nucleus speckle Cytoplasm.


FUNCTION: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. May be required to embody the molecular ruler of the complex (By similarity). SIMILARITY: Belongs to the SEN54 family.


FUNCTION: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the succinate/malate CoA ligase beta subunit family.


FUNCTION: Effector that specifically binds host autophagy protein ATG8CL of the ATG8 family to stimulate autophagosome formation and subsequent autophagy rather than blocking autophagic flux (PubMed:26765567, PubMed:29932422). The pathogen remodels host-microbe interface by co-opting the host autophagy machinery which plays a key role in plant immunity (PubMed:29932422). PexRD54 competes with the autophagy cargo receptor Joka2 to deplete it out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense (PubMed:26765567, PubMed:29932422). SUBCELLULAR LOCATION: Secreted Host nucleus Host cytoplasm Note=Localizes to host autophagosomes across the perimicrobial membrane. SIMILARITY: Belongs to the RxLR effector family.


FUNCTION: Effector that is involved in host plant infection. Contributes to virulence during the early infection stage, by inhibiting plant defense responses induced by both PAMP-triggered immunity (PTI) and effector-triggered immunity (ETI). SUBCELLULAR LOCATION: Secreted Host cell. SIMILARITY: Belongs to the RxLR effector family.


FUNCTION: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. FUNCTION: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity). SUBCELLULAR LOCATION: Cytoplasm. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. SIMILARITY: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.


FUNCTION: May help in the organization of the PsaE and PsaF subunits. SUBCELLULAR LOCATION: Cellular thylakoid membrane; Single-pass membrane protein. SIMILARITY: Belongs to the PsaJ family.


FUNCTION: Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-2604 in 23S ribosomal RNA and from uracil-35 in the anticodon of tRNA(Tyr). SIMILARITY: Belongs to the pseudouridine synthase RsuA family.


FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Present within the clusters of tubulo-vesicular structures of Golgi membrane and cis-Golgi membranes.


FUNCTION: Probable ion channel. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the TMC family.


FUNCTION: Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (By similarity). FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs). In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites (By similarity). SUBCELLULAR LOCATION: Nucleus Note=Localizes to nuclear foci following DNA damage. SIMILARITY: Belongs to the Integrator subunit 3 family.


FUNCTION: A beta subtype methylase that recognizes the double-stranded sequence 5'-GANTC-3' and methylates A-2 on both strands (PubMed:12654995) (By similarity). CcrM-mediated methylation has important cellular functions. Contributes to the accurate cell-cycle control of DNA replication and cellular morphology (By similarity). SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.


FUNCTION: Produces ATP from ADP in the presence of a proton gradient across the membrane. SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Peripheral membrane protein. SIMILARITY: Belongs to the ATPase epsilon chain family.


FUNCTION: Catalyzes the oxidation of levoglucosan (1,6-anhydro-beta-D- glucose, LG) to 3-dehydrolevoglucosan (3-keto-LG) (PubMed:30224354). Exhibits high substrate specificity toward levoglucosan and NAD(+) for the oxidative reaction (PubMed:30224354). Exhibits weak activities (about 4% compared with that of LG) toward L-sorbose and 1,5-anhydro-D- glucitol, and activity toward D-xylose is also detectable (1.7%) (PubMed:30224354). Can also efficiently catalyzes the NADH-dependent reduction (reverse reaction) of 3-keto-LG (PubMed:30224354). SIMILARITY: Belongs to the Gfo/Idh/MocA family.


FUNCTION: May be involved in oxidative stress response. SUBCELLULAR LOCATION: Plastid, chloroplast. SIMILARITY: Belongs to the peptidase C56 family.


FUNCTION: Blocks both human ERG1/Kv11.1/KCNH2 potassium channels (in a reversible manner) (PubMed:14599291) and A-type voltage-gated potassium channels Kv4/KCND (in an irreversible manner) (PubMed:11457451, PubMed:12473099, PubMed:12637022). The presence of the Kv4-associated proteins DPP6 or DPP10 is mandatory to have high-affinity blockade of Kv4.2/KCND2 and Kv4.3/KCND3 channels (By similarity). In contrast, the presence of the Kv4-associated protein KChIP1/KCNIP1 does not enhance the affinity blockade (By similarity). May dispose of two functional faces (A and B); the two basic residues (Arg-40 and Lys-41) on the alpha-helix side of the peptide that blocks the hERG current (face A) and the typical dyad through which it blocks A-type currents on the beta-sheet side (face B) (PubMed:14599291). In adult rat brain, it binds to sites in the striatum, hippocampus, superior colliculus, and cerebellum. It shares the same target in rat brain than AaTX1 (AC Q867F4) and AmmTX3 (AC P60208). In DPP6 knockout mice, A-type currents are much less affected by the toxin than in wild-type mice (PubMed:23440961). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 15 subfamily.


FUNCTION: Catalyzes the transformation of cystathionine into homocysteine (PubMed:19035565). Can also catalyze, at low levels, the conversion of cystathionine into methionine and the conversion of methionine into methanethiol (PubMed:19035565). SIMILARITY: Belongs to the trans-sulfuration enzymes family.


FUNCTION: pEKW peptides may serve as metalloproteinase inhibitors during glandular storage. Their inhibition may be instantly disengaged, by dilution or physiochemical change, when venom is injected into tissue of the victim. FUNCTION: [C-type natriuretic peptide]: Exhibits hypotensive and vasodepressor activity. Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3) (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: In the C-terminal section; belongs to the natriuretic peptide family.


FUNCTION: dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs. SIMILARITY: Belongs to the dGTPase family. Type 1 subfamily.


FUNCTION: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). SIMILARITY: Belongs to the BCKDHA family.


FUNCTION: Polyprenyl transferase; part of the gene cluster that mediates the biosynthesis of yanuthone D, a fungal isoprenoid epoxycyclohexenone that acts as an antibiotic against fungi and bacteria (PubMed:24684908). The first step of the pathway is the synthesis of 6-methylsalicylic acid (6-MSA) by the polyketide synthase yanA (PubMed:24684908). 6-MSA is then converted to m-cresol by the decarboxylase yanB (PubMed:24684908). The cytochrome P450 monooxygenase yanC then catalyzes the oxidation of m-cresol to toluquinol (PubMed:24684908). Epoxidation of toluquinol is then performed by the short chain dehydrogenase yanD, with the help of yanE, and a further prenylation by yanG leads to 7-deacetoxyyanuthone A (PubMed:24684908). The next step is the hydroxylation of C-22 of 7-deacetoxyyanuthone A by the cytochrome P450 monooxygenase yanH to yield 22-deacetylyanuthone A (PubMed:24684908). O-Mevalon transferase yanI then attaches mevalon to the hydroxyl group of 22-deacetylyanuthone A to produce yanuthone E (PubMed:24684908). Finally, the FAD-dependent monooxygenase yanF oxidizes the hydroxyl group at C15 of yanuthone E to form yanuthone D (PubMed:24684908). Furthermore, several branching points in the pathway lead to the production of yanuthones F and G from 7-deacetoxyyanuthone A; yanuthones H and I from 22-deacetylyanuthone A; and yanuthone J from yanuthone E (PubMed:24684908). YanG is also involved in the synthesis of yanuthone X1 which does not have 6-methylsalicylic acid (6-MSA) as precursor (PubMed:24684908). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the UbiA prenyltransferase family.


FUNCTION: This protein is a zinc protease from snake venom that is devoid of significant myotoxic and hemorrhagic activities. It hydrolyzes the Aalpha-chain and more slowly the Bbeta-chain of fibrin and fibrinogen, without affecting the gamma-chains. It induces cell detachment and a apoptosis (anoikis) in endothelial cells. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the venom metalloproteinase (M12B) family. P-I subfamily.


FUNCTION: Role in sperm cell division, maturation, or function. The relative order of ligand affinity is GRP = neuromedin-C >> neuromedin- B. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.


FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels (PubMed:15538383). Binds to ODC/SPE1 monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:18089576). SIMILARITY: Belongs to the ODC antizyme family.


FUNCTION: Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis (By similarity). Involved in the development of the sporozoite in the mosquito vector midgut (PubMed:26796412). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.


FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA- degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SUBCELLULAR LOCATION: Nucleus Cytoplasm. SIMILARITY: Belongs to the SKI8 family.


FUNCTION: F-box protein component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). The SCF(DIA2) complex is specifically involved in the pheromone induced degradation of phosphorylated TEC1. The SCF(DIA2) complex binds to DNA replication origins. Involved in DNA replication, genome stability, and the control of cell cycle, probably through its association to replication origins to facilitate the ubiquitination of another origin- binding protein. Required for invasive growth and growth under alkaline conditions. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the DIA2 family.


FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins (PubMed:27528192). This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity). SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the peptidase T1B family.


FUNCTION: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation. SUBCELLULAR LOCATION: Plastid, chloroplast. SIMILARITY: Belongs to the bacterial ribosomal protein bL12 family.


FUNCTION: Binds to the embryo specification element and the ABA- responsive element (ABRE) of the Dc3 gene promoter. Could participate in abscisic acid-regulated gene expression during seed development. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the bZIP family. ABI5 subfamily.


FUNCTION: Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofuranosyl residues. SUBCELLULAR LOCATION: Cell membrane. SIMILARITY: Belongs to the glycosyltransferase 2 family.


FUNCTION: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family.


FUNCTION: C-8 sterol isomerase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4- dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3- beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron- containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C- methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl- methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen- 3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. SIMILARITY: Belongs to the ERG2 family.


FUNCTION: Has no esterase activity. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.


FUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the IPK1 type 2 family.


FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with smg1 and smg8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between smg1 and smg8 (By similarity). SIMILARITY: Belongs to the SMG9 family.


FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the eIF-3 subunit K family.


FUNCTION: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (PubMed:20802492). Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery (PubMed:20802492, PubMed:21902732). In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins (PubMed:20802492). Positively controls H(2)O(2)-induced cell death (PubMed:19194512). SUBCELLULAR LOCATION: Cytoplasm Mitochondrion Note=Relocalizes to mitochondria after H(2)O(2) exposure. SIMILARITY: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. SIMILARITY: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. SIMILARITY: In the N-terminal section; belongs to the flavodoxin family.


FUNCTION: As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the TMEM186 family.


FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the eukaryotic ribosomal protein eL31 family.


FUNCTION: Hydroxycinnamoyl transferase involved in the conjugation of feruloyl CoA to spermidine (PubMed:19077165, PubMed:19762055, PubMed:33519864). Catalyzes the three conjugating steps required for the biosynthesis of N(1),N(4),N(8)-triferuloyl-spermidine (PubMed:19077165, PubMed:33519864). Spermidine is the only acceptor substrate while feruloyl CoA > caffeoyl CoA > coumaroyl CoA > cinnamoyl CoA >> sinapoyl CoA are efficient acyl donors. No activity with hydroxyferuloyl CoA (PubMed:19077165). Required for the biosynthesis of these conjugated spermidine derivatives, specifically in anther tapetum (PubMed:22912643). SIMILARITY: Belongs to the plant acyltransferase family.


FUNCTION: Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs). FUNCTION: Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs). SUBCELLULAR LOCATION: Periplasm. SUBCELLULAR LOCATION: Periplasm. SIMILARITY: Belongs to the OpgD/OpgG family. SIMILARITY: Belongs to the OpgD/OpgG family.


FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). SIMILARITY: Belongs to the class-I DAHP synthase family.


FUNCTION: Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. SIMILARITY: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.


FUNCTION: Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat. FUNCTION: Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat (By similarity). FUNCTION: Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat (By similarity). SUBCELLULAR LOCATION: Secreted. SUBCELLULAR LOCATION: Secreted. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the corazonin family. SIMILARITY: Belongs to the corazonin family.


FUNCTION: Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzA1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. SIMILARITY: Belongs to the PhzA/PhzB family.


FUNCTION: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein Early endosome Note=Clustered upon activation and targeted to early endosome. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.


SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: To M.thermoautotrophicum MTH1250.


SIMILARITY: Belongs to the glycosyl hydrolase 52 family.


FUNCTION: Expression is induced during oxidative stress. Plays an essential, SCF-independent, role in the stress response to hydrogen peroxide for survival, by negatively regulating ergosterol synthesis via direct binding to the squalene synthase erg9. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Associated with vesicle-like and endoplasmic reticulum (excluding a nuclear rim) structures.


FUNCTION: Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation (By similarity). SUBCELLULAR LOCATION: Secreted. Cytoplasmic vesicle, secretory vesicle, chromaffin granule Nucleus Cytoplasm Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytosol Endoplasmic reticulum Note=Present in chromaffin granules. Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis (By similarity). SIMILARITY: Belongs to the clusterin family.


FUNCTION: Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (By similarity). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'- hydroxyl ends (By similarity). Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (By similarity). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway (By similarity). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (By similarity). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). SUBCELLULAR LOCATION: Nucleus Cytoplasm Mitochondrion Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. SIMILARITY: Belongs to the DNA repair enzymes AP/ExoA family.


FUNCTION: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division. Promotes physical and functional coordination of the PBP1B-LpoB and Tol machines, and regulates PBP1B activity in response to Tol energy state. SUBCELLULAR LOCATION: Periplasm Note=Targeting to the Sec-translocase for transport across the inner membrane is SecB-dependent (PubMed:16352602). Localizes to the septum concurrent with PBP1B-LpoB and Tol at the onset of constriction (PubMed:25951518). Localization is dependent on divisome assembly and requires ongoing septal peptidoglycan synthesis (PubMed:25951518). SIMILARITY: Belongs to the CpoB family.


FUNCTION: Structural protein that forms a matrix surrounding the mature virion (MV) through interaction with protein A26. Presence of protein A25 in the virion structurally prevents direct virus-cell fusion mechanism. SUBCELLULAR LOCATION: Virion. Note=Present above the membrane of mature virions (MV). SIMILARITY: Belongs to the poxviridae A25 protein family.


FUNCTION: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton Cytoplasm Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Note=Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis. SIMILARITY: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.


FUNCTION: May participate in wall plasticization and/or intussusception or in cell wall turnover. SUBCELLULAR LOCATION: Secreted, cell wall. Membrane; Peripheral membrane protein.


FUNCTION: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:7954810, PubMed:9786857, PubMed:9671728, PubMed:10471110, PubMed:12235169, PubMed:11970897, PubMed:15699031, PubMed:28178239, PubMed:24858472, PubMed:19527715) (Probable). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl- CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:10593920, PubMed:12235169, PubMed:12937175). May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation (PubMed:14991074, PubMed:15897321). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:12235169). May be involved in regulation of cholesterol metabolism (PubMed:12235169). Probably involved in fatty acid transport across the blood barrier (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein Mitochondrion outer membrane Endomembrane system; Single-pass membrane protein Cytoplasm Note=Plasma membrane and intracellular membranes, at least in adipocytes (PubMed:10593920, PubMed:11970897, PubMed:28178239). In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake (PubMed:11970897, PubMed:28178239). Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1 (PubMed:11970897, PubMed:28178239). Predominantly cytoplasmic in myocytes (PubMed:15897321). SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.


FUNCTION: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR- induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells. SUBCELLULAR LOCATION: Membrane; Single- pass type I membrane protein. SIMILARITY: Belongs to the DAP10 family.


SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the UPF0266 family.


SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the nematode receptor-like protein sre family.


FUNCTION: Functions as substrate-specific channel for nucleosides and deoxynucleosides. Functions also in albicidin uptake and as receptor for colicin K. Is also a receptor for several Tsx-specific bacteriophages. SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.


FUNCTION: Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein Secreted Note=Resides in the Golgi apparatus membrane and is secreted following propeptide cleavage. SIMILARITY: Belongs to the FAM20 family.


FUNCTION: Catalyzes the formation of 5-methyl-uridine at position equivalent to 747 (m5U747) in 23S rRNA. SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.


FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth (By similarity).


FUNCTION: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. SUBCELLULAR LOCATION: Plastid, chloroplast.


FUNCTION: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns. SUBCELLULAR LOCATION: Plastid. SIMILARITY: Belongs to the intron maturase 2 family. MatK subfamily.


FUNCTION: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.


FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity). SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the GcvP family.


FUNCTION: Probable microtubule-associated force-producing protein that is targeted to the forming cell plate during cytokinesis. May play a role in cell division. SUBCELLULAR LOCATION: Cytoplasm Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, phragmoplast Note=Localizes in the forming cell plate during cytokinesis. SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


FUNCTION: Voltage-gated chloride channel (PubMed:1659664). Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClC- 1/CLCN1 subfamily.


FUNCTION: Acts as an aphrodisiac pheromone, reliably eliciting copulatory behavior from male hamster. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.


FUNCTION: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.


FUNCTION: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side Endosome membrane; Peripheral membrane protein; Cytoplasmic side. SIMILARITY: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.


FUNCTION: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA. SUBCELLULAR LOCATION: Cytoplasm. Note=After completion of the hook- basal body structure, it is exported out of the cell through the completely assembled hook-basal body structures. SIMILARITY: Belongs to the FlgM family.


FUNCTION: Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate. SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily.


FUNCTION: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Transfers the gamma-phosphate of ATP to the 4'- position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses (Potential). SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the LpxK family.


FUNCTION: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein Cell membrane Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes. SIMILARITY: Belongs to the NHER family.


SIMILARITY: Belongs to the WD repeat DGR2 family.


FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). SUBCELLULAR LOCATION: Mitochondrion Mitochondrion inner membrane. SIMILARITY: Belongs to the eukaryotic ATPase B chain family.


FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. SUBCELLULAR LOCATION: Nucleus Chromosome Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. SIMILARITY: Belongs to the MCM family.


SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily.


FUNCTION: Essential for virus function.


FUNCTION: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Also plays an important role in establishment of the anterior-posterior body axis formation during development. SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane; Multi-pass membrane protein Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein Golgi apparatus membrane; Multi-pass membrane protein Early endosome membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the wntless family.


FUNCTION: Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate. Allows growth on ACC as a nitrogen source. SIMILARITY: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.


FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. SIMILARITY: Belongs to the complex I 49 kDa subunit family.


FUNCTION: Catalyzes the NADH-dependent reduction of the oxo group at C3 of 3-dehydro-D-glucosides leading to D-glucosides. Probably functions in a metabolic pathway that transforms D-gulosides to D-glucosides. Can use 3-dehydro-D-glucose, methyl alpha-3-dehydro-D-glucoside and methyl beta-3-dehydro-D-glucoside as substrates in vitro. However, the actual specific physiological substrates for this metabolic pathway are unknown. To a lesser extent, is also able to catalyze the reverse reactions, i.e. the NAD(+)-dependent oxidation of the hydroxyl group at C3 of D-glucosides leading to 3-dehydro-D-glucosides. Cannot act on UDP-glucose, UDP-N-acetyl-D-glucosamine, D-glucosamine, N-acetyl-D- glucosamine, or UDP-D-galactose. SIMILARITY: Belongs to the Gfo/Idh/MocA family.


FUNCTION: Involved in plasmid partition. SIMILARITY: Belongs to the site-specific recombinase resolvase family.


FUNCTION: May function as a multidomain RNA-binding protein. May play a role in nuclear RNA processing and in early development. SUBCELLULAR LOCATION: Microsome membrane; Peripheral membrane protein. Nucleus Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Initially a peripheral membrane protein associated with the microsomal membrane fractions. May be targeted to the nucleus later in development.


FUNCTION: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1/sscA) (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Single-pass membrane protein. SIMILARITY: Belongs to the TIM14 family.


FUNCTION: Antimicrobial peptide active against Gram-positive bacteria (MIC=4->125 ug/ml) (PubMed:22983711). May act by forming transmembrane ion channels, since the peptide rapidly depolarizes the bacterial cytoplasmic membrane, simultaneously decreasing the membrane potential and intracellular potassium contents (PubMed:22983711).


FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the sulfotransferase 1 family.


FUNCTION: Probably contributes, directly or indirectly, to early events in germination. SUBCELLULAR LOCATION: Forespore inner membrane; Lipid-anchor.


FUNCTION: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. SUBCELLULAR LOCATION: Cytoplasm Note=The SRP-RNC complex is targeted to the cytoplasmic membrane. SIMILARITY: Belongs to the GTP-binding SRP family. SRP54 subfamily.


FUNCTION: Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the GlpE family.


FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the phage and mitochondrial RNA polymerase family.


FUNCTION: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein; Cytoplasmic side. SIMILARITY: In the C-terminal section; belongs to the peptidase M41 family. SIMILARITY: In the central section; belongs to the AAA ATPase family.


FUNCTION: Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity). This toxin acts on sphingomyelin (SM) (By similarity). It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity). It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity). In vivo, intradermal injection induces dermonecrosis (PubMed:8819009). Induces hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the arthropod phospholipase D family. Class I subfamily.


FUNCTION: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Acts as a transcriptional modulator for ESR1. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the SFR1/MEI5 family.


FUNCTION: Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA) molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Orco subfamily.


FUNCTION: Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA. Catalyzes the second reaction step on the main metabolic degradation pathway for L-threonine. SUBCELLULAR LOCATION: Mitochondrion Nucleus Note=Translocates to the nucleus upon cold and osmotic stress. SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.


FUNCTION: May be required for viral persistance in the host.


FUNCTION: Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of KbaY. When expressed alone, KbaZ does not show any aldolase activity. SIMILARITY: Belongs to the GatZ/KbaZ family. KbaZ subfamily.


FUNCTION: Receptor for angiotensin II, a vasoconstricting peptide (PubMed:8185599, PubMed:28379944, PubMed:29967536, PubMed:31899086). Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways (PubMed:28379944). Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15123706). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.


FUNCTION: Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays an essential role in testis development (By similarity). Plays a critical role in tumourigenesis. SUBCELLULAR LOCATION: [ADGRG1 N-terminal fragment]: Secreted Note=Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [ADGRG1 C-terminal fragment]: Membrane raft. SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.


SIMILARITY: Belongs to the mimivirus R546 family.


FUNCTION: Binds cellulosic and pectic substrates. Displays no enzyme activity (in vitro). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor.


FUNCTION: (Microbial infection) Susceptibility host factor required for viral infection (e.g. Potato virus Y (PVY)) by recruiting viral RNAs to the host ribosomal complex via an interaction with viral genome-linked protein (VPg) (PubMed:22146867). Displayed sequence is the allele Eva1 that confers resistance to potato virus Y (PVY) by failing to interact with the viral VPg protein (PubMed:22146867). FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (By similarity). Key component of recessive resistance to potyviruses (PubMed:22146867). SUBCELLULAR LOCATION: Nucleus Cytoplasm. SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.


FUNCTION: Chaperone that confers thermal protection to other proteins. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the small heat shock protein (HSP20) family.


FUNCTION: Transcriptional coactivator for creb1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of creb1 'Ser-119' phosphorylation. Enhances the interaction of creb1 with taf4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of ppargc1a and inducer of mitochondrial biogenesis in muscle cells (By similarity). SUBCELLULAR LOCATION: Nucleus Cytoplasm Note=Appears to be mainly nuclear. SIMILARITY: Belongs to the TORC family.


FUNCTION: Polycomb group (PcG) protein (PubMed:1898775). PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (PubMed:1898775, PubMed:11493925, PubMed:11583617). PcG proteins are not required to initiate repression, but to maintain it during later stages of development (PubMed:1898775). Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility (PubMed:11493925, PubMed:11583617). Promotes locus- specific chromatin compaction (PubMed:11493925, PubMed:11583617). Binds to (N(6)-methyladenosine) DNA and thereby might implement repression of specific loci (PubMed:30078725). SUBCELLULAR LOCATION: Nucleus.


FUNCTION: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). FUNCTION: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32165585). SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the V-ATPase proteolipid subunit family.


SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.


FUNCTION: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the thioredoxin family. DsbD subfamily.


FUNCTION: Downstream effector for RAB11. May be involved in vesicle recycling (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endosome membrane. Golgi apparatus, trans-Golgi network. Note=Colocalized with RAB11 along microtubules oriented toward lamellipodia.


FUNCTION: Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5- phosphopentoses. Catalyzes the interconversion of glucose-1-phosphate into glucose-6-phosphate but with a lower catalytic efficiency. In vitro, has also a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant. SUBCELLULAR LOCATION: Cytoplasm, cytosol. SIMILARITY: Belongs to the phosphohexose mutase family.


FUNCTION: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the insulin family.


FUNCTION: Low-potential cytochrome c that plays a role in the oxygen- evolving complex of photosystem II. SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side Note=Associated with photosystem II at the lumenal side of the thylakoid membrane. SIMILARITY: Belongs to the cytochrome c family. PsbV subfamily.


FUNCTION: The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspB is involved in transcription regulation (By similarity). FUNCTION: The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspB is involved in transcription regulation. SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. SIMILARITY: Belongs to the PspB family.


FUNCTION: Required for constitutive and alternative pre-mRNA splicing (Probable). Involved in primary miRNA processing and pri-miRNA biogenesis. Binds both intronless and intron-containing pri-miRNAs (PubMed:26227967). SUBCELLULAR LOCATION: Nucleus Nucleus speckle. SIMILARITY: Belongs to the splicing factor SR family. RS subfamily.


FUNCTION: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. To a lesser extent, is also able to utilize other nucleotides such as CTP and GTP as substrates, producing the modified coenzymes, flavin cytosine dinucleotide (FCD) and flavin guanine dinucleotide (FGD), respectively. Does not catalyze the reverse reaction to produce FMN and ATP from FAD and PPi. Does not function as a glycerol-3- phosphate cytidylyltransferase, as previously annotated in the complete genome. SIMILARITY: Belongs to the archaeal FAD synthase family.


FUNCTION: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1- phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity). SIMILARITY: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.


FUNCTION: Putative transcriptional regulator. SIMILARITY: Belongs to the Tfx family.


FUNCTION: Possible member (with IbpA) of a two partner secretion pathway (TPS) in which it would mediate the secretion of protein IbpA (high molecular weight immunoglobulin-binding protein). SUBCELLULAR LOCATION: Cell outer membrane. SIMILARITY: Belongs to the TPS (TC 1.B.20) family.


FUNCTION: May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. SUBCELLULAR LOCATION: Postsynaptic density Presynapse Postsynapse Cytoplasm, cytosol Note=Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons.


FUNCTION: Zinc transporter. Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.


FUNCTION: Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen. SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein Cell projection, axon Note=In neurons, located in soma. SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.


FUNCTION: Catalyzes the hydrolysis of linear beta-1,2-glucan and beta- 1,2-glucooligosaccharides with degrees of polymerization (DPs) greater than or equal to 4, to produce sophorose. The best substrates are tetra- and pentasaccharides. Acts as an exo-type enzyme that releases sophorose from the non-reducing end of the substrate. It cannot hydrolyze cyclic beta-1,2-glucans. SUBCELLULAR LOCATION: Periplasm.


FUNCTION: Involved in the oxidative degradation of abscisic acid. SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein. SIMILARITY: Belongs to the cytochrome P450 family.


FUNCTION: Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis. SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein Note=Enriched in early compartments of the secretory pathway including COPII-coated vesicles and the Golgi cis cisterna. SIMILARITY: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.


FUNCTION: Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.


FUNCTION: Secondary metabolism regulator that controls the expression of the tenuazonic acid biosynthesis cluster (PubMed:28820236). Methyltransferase that performs automethylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the methyltransferase superfamily. LaeA methyltransferase family.


FUNCTION: May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN (By similarity). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix Zymogen granule lumen Golgi apparatus lumen. SIMILARITY: Belongs to the jacalin lectin family.


FUNCTION: Plays a critical role in catalyzing the release of class II- associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. SUBCELLULAR LOCATION: Late endosome membrane; Single-pass type I membrane protein Lysosome membrane; Single-pass type I membrane protein Note=Localizes to late endocytic compartment. Associates with lysosome membranes. SIMILARITY: Belongs to the MHC class II family.


SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.


FUNCTION: May mediate extracellular signals to regulate transcription in differentiating cells. SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.


FUNCTION: Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:12464436, PubMed:28073917). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation. Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:24037507). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Plays also a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (By similarity).


FUNCTION: Not known; mutations in apaG/corD give a phenotype of low- level Co(2+) resistance. They also decrease Mg(2+) efflux but not influx via the CorA Mg(2+) transport system.


FUNCTION: Glycosyltransferase involved in the arabinosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms (PubMed:22215597). Possesses alpha-1,3- arabinosyltransferase activity, transferring an arabinofuranose residue to the xylan backbone (PubMed:22215597). SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein. SIMILARITY: Belongs to the glycosyltransferase 61 family.


FUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). SUBCELLULAR LOCATION: Nucleus, nucleolus Nucleus, Cajal body Note=Also localized to Cajal bodies (coiled bodies). SIMILARITY: Belongs to the GAR1 family.


FUNCTION: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. SUBCELLULAR LOCATION: Cell membrane Vacuole membrane; Peripheral membrane protein. SIMILARITY: Belongs to the V-ATPase G subunit family.