FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID- A, TFIID-B, and TFIID-C. TAF6 homodimer connects TFIID modules, forming a rigid core. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the TAF6 family.


FUNCTION: Involved in the biosynthesis of valencene, a major volatile emitted from flowers of grapevine. Can use farnesyl diphosphate as substrate, but not geranyl diphosphate or geranylgeranyl diphosphate. Produces mainly (+)-valencene and (-)-7-epi-alpha-selinene along with five minor products. SUBCELLULAR LOCATION: Cytoplasm Note=Localizes close to lipid bodies in maturing microspores. SIMILARITY: Belongs to the terpene synthase family. Tpsa subfamily.


FUNCTION: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of Cbp20 and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the NCBP1 family.


SUBCELLULAR LOCATION: Cytoplasm. Nucleus. SIMILARITY: Belongs to the REXO1/REXO3 family.


FUNCTION: Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton Cell projection, lamellipodium Cell projection, ruffle Cell projection, microvillus Cell projection, filopodium tip Cell projection, filopodium Note=Rapidly redistributed to ruffles and lamellipodia structures in response to autotaxin, lysophosphatidic acid (LPA) and epidermal growth factor (EGF) treatment. Redistributed to the leading edge of hepatocyte growth factor (HGF)-induced lamellipodia (By similarity). SIMILARITY: Belongs to the villin/gelsolin family.


FUNCTION: Hydrolysis of carbamoyl and sulfocarbamoyl esters of paralytic shellfish toxins. Ester hydrolysis is unaffected by the presence or absence of a hydroxyl moiety at the N-1 postion of the substrate toxin but is significantly affected by the stereochemistry of sulfate esters at C-11 of the substrate toxin.


FUNCTION: Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria (By similarity). SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the RRF family.


FUNCTION: Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. SIMILARITY: Belongs to the LysR transcriptional regulatory family.


FUNCTION: Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpene eremophilene via a 1,10- cyclization, which requires the abstraction of the pyrophosphate from FPP to yield the (E,E)-germacradienyl cation. The only accepted substrate is farnesyl diphosphate (FPP). SIMILARITY: Belongs to the terpene synthase family.


FUNCTION: [p8]: Component of the core shell. FUNCTION: [Polyprotein pp62]: Essential for the correct assembly and maturation of the core of the virion. FUNCTION: [p15]: Component of the core shell (By similarity). Binds to phosphatidylserine and DNA, which may link the core shell to the inner membrane and to the viral nucleoid (By similarity). FUNCTION: [p35]: Component of the core shell (By similarity). Binds to phosphatidylserine, which may enable the core shell binding with the inner membrane (By similarity). SUBCELLULAR LOCATION: [p35]: Virion Note=Located in the core shell, which functions like a matrix between the DNA and the inner envelope. SUBCELLULAR LOCATION: [Polyprotein pp62]: Host cytoplasm, host perinuclear region Note=Found in perinuclear cytoplasmic viral factories during assembly. SUBCELLULAR LOCATION: [p15]: Virion Note=Located in the core shell, which functions like a matrix between the DNA and the inner envelope. SIMILARITY: Belongs to the asfivirus polyprotein pp62 family.


FUNCTION: Catalyzes the reversible deamination of L-leucine to 4- methyl-2-oxopentanoate. SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.


FUNCTION: Involved in the biosynthesis of tryptamine. Supplies tryptamine for the indole moiety of camptothecin (CPT), an anti-cancer monoterpene alkaloid. Represents a key step in monoterpene indole alkaloid biosynthesis. Is specific for tryptophan, and inactive against tyrosine, phenylalanine and 3,4-dihydroxyphenylalanine (dopa). SIMILARITY: Belongs to the group II decarboxylase family.


FUNCTION: Involved in the assembly of chloroplastic iron-sulfur proteins. Is able to transfer iron-sulfur clusters to apo-ferredoxin. SUBCELLULAR LOCATION: Plastid, chloroplast stroma. SIMILARITY: Belongs to the HesB/IscA family. Ycf83 subfamily.


FUNCTION: Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity). SUBCELLULAR LOCATION: Mitochondrion matrix. SIMILARITY: Belongs to the peptidase M3 family.


FUNCTION: Flavonoid 6-O-methyltransferase involved in the biosynthesis of polymethoxylated flavonoids natural products such as nevadensin and salvigenin, aroma compounds which contribute to the flavor of sweet basil, and exhibit pharmacological activities such as anti-allergic, anti-oxidant, antibacterial, anti-proliferative, and anti-inflammatory effects (PubMed:22923679). Catalyzes S-adenosylmethionine-dependent regioselective 6-O-methylation of flavonoids; active on various hydroxylated flavonoid substrates, including scutellarein-7-methyl ether (SCU7Me) and ladanein (LAD), and, with a lower efficiency, chrysoeriol (CHRYS) and cirsioliol (CIRL) (PubMed:22923679). SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.


FUNCTION: Has ADP-ribosyltransferase activity toward GLP1R. SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor. SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase family.


FUNCTION: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. FUNCTION: [Isoform 2]: Inactive transporter. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.


FUNCTION: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1- diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'- monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine. SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.


FUNCTION: In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips. SUBCELLULAR LOCATION: Virion membrane; Single-pass membrane protein Host cell membrane; Single-pass type I membrane protein Host cell junction Host Golgi apparatus membrane; Single-pass type I membrane protein Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). The heterodimer gE/gI then redistribute to cell junctions to promote cell-cell spread later in the infection (By similarity). SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein I family.


FUNCTION: UDP-glucosyltransferase that forms glucose esters with phenylpropanoids (PubMed:11042211, PubMed:11187886). Glucosylates 4- coumarate, ferulate, caffeate, sinapate and cinnamate (PubMed:11042211, PubMed:11187886). Can glucosylate the phytotoxic xenobiotic compound 2,4,5-trichlorophenol (TCP) (PubMed:12721858). SIMILARITY: Belongs to the UDP-glycosyltransferase family.


FUNCTION: Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles (By similarity). SUBCELLULAR LOCATION: Mitochondrion matrix. SIMILARITY: Belongs to the aldehyde dehydrogenase family.


FUNCTION: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms (By similarity). SUBCELLULAR LOCATION: Mitochondrion Mitochondrion matrix. SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.


FUNCTION: Assembles to form an icosahedral capsid with a T=13 symmetry. Drives the penetration of the inner capsid (core) into the cytoplasm. SUBCELLULAR LOCATION: Virion. Note=Outer capsid protein (600 copies).


FUNCTION: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. SUBCELLULAR LOCATION: [Pro-neuregulin-3, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein Note=Does not seem to be active. SUBCELLULAR LOCATION: [Neuregulin-3]: Secreted. SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form. SIMILARITY: Belongs to the neuregulin family.


FUNCTION: Potent and specific blocker of Kv4.2/KCND2 (IC(50)=5 nM) and Kv4.3/KCND3 (IC(50)=28 nM) potassium channels (PubMed:10051143). Acts by altering the gating properties of these channels (PubMed:10051143). Also shows moderate inhibition on human voltage-gated sodium channel Nav1.7/SCN9A activation (IC(50)=423 nM) (PubMed:25026046). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the neurotoxin 30 (phrixotoxin) family.


SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. SIMILARITY: Belongs to the UPF0754 family.


FUNCTION: Binds to DNA in a highly cooperative manner without pronounced sequence specificity. During synthesis of the single- stranded (progeny) viral DNA, prevents the conversion into the double- stranded replicative form. G5P is displaced by the capsid protein G8P during phage assembly on the inner bacterial membrane (By similarity). SIMILARITY: Belongs to the inovirus G5P protein family.


FUNCTION: Thrombin-like snake venom serine protease that cleaves alpha- chain of fibrinogen (FGA) releases only fibrinopeptide A. Shows coagulant, esterase and amidase activities. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the peptidase S1 family. Snake venom subfamily.


FUNCTION: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. FUNCTION: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria. SUBCELLULAR LOCATION: Cellular thylakoid membrane; Single-pass membrane protein. SIMILARITY: Belongs to the ATPase B chain family.


FUNCTION: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the TOP6A family.


FUNCTION: Seems to act as a chloride ion channel (PubMed:30157172). Plays a role in retina development (PubMed:30157172). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein Golgi apparatus membrane; Multi-pass membrane protein Nucleus membrane; Multi- pass membrane protein Note=Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes. SIMILARITY: Belongs to the chloride channel MCLC family.


FUNCTION: Probable component of transcriptional regulatory complex with SMAD protein daf-3 (PubMed:14681186). Required to regulate entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions (PubMed:14681186). Involved in larvae undergoing cell-cycle arrest during the dauer stage (PubMed:14681186). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the SKI family.


FUNCTION: May play a protective role in mucosal tissues by preventing exaggerated allergic responses. SUBCELLULAR LOCATION: Mitochondrion.


FUNCTION: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport (By similarity). SUBCELLULAR LOCATION: Cytoplasm Nucleus.


FUNCTION: Participates in ABA-regulated gene expression during seed development and subsequent vegetative stage by acting as the major mediator of ABA repression of growth. Binds to the embryo specification element and the ABA-responsive element (ABRE) of the Dc3 gene promoter and to the ABRE of the Em1 and Em6 genes promoters. Can also trans- activate its own promoter, suggesting that it is autoregulated. Plays a role in sugar-mediated senescence. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the bZIP family. ABI5 subfamily.


FUNCTION: Protects cells against oxidative stress and cell death. SIMILARITY: Belongs to the peptidase C56 family.


FUNCTION: [Endosome lysis protein]: Structural component of the virion that provides increased stability to the particle shell through its interaction with the core-capsid bridging protein and the hexon-linking protein VIII. Fibers shedding during virus entry into host cell allows the endosome lysis protein to be exposed as a membrane-lytic peptide. Exhibits pH-independent membrane fragmentation activity and probably mediates viral rapid escape from host endosome via organellar membrane lysis. It is not clear if it then remains partially associated with the capsid and involved in the intracellular microtubule-dependent transport of capsid to the nucleus, or if it is lost during endosomal penetration. FUNCTION: [Pre-protein VI]: During virus assembly, promotes hexon trimers nuclear import through nuclear pore complexes via an importin alpha/beta-dependent mechanism. By analogy to herpesviruses capsid assembly, might act as a chaperone to promote the formation of the icosahedral capsid. FUNCTION: [Protease cofactor]: Cofactor that activates the viral protease. Binds to viral protease in a 1:1 ratio. SUBCELLULAR LOCATION: [Pre-protein VI]: Host nucleus Host cytoplasm Note=Shuttles between host cytoplasm and nucleus. SUBCELLULAR LOCATION: [Endosome lysis protein]: Virion Note=Associates with the base of each peripentonal hexon on the capsid interior. Present in around 360 copies per virion. SIMILARITY: Belongs to the adenoviridae protein VI family.


FUNCTION: Met-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Enkephalin peptides found in Meiacanthus fangblennies induce physiological effects via their interaction with delta-type opioid receptors (OPRD1) (tested on M.grammistes). Therefore, finding a proenkephalin sequence in M.atrodorsalis venom suggests that this protein act in the same manner (Probable). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the opioid neuropeptide precursor family.


FUNCTION: Works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). Ectopic expression partially complements a cobB deletion allowing some growth on propionate (PubMed:12700259). Restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions (PubMed:26448059). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the acetokinase family. PduW subfamily.


FUNCTION: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region.


FUNCTION: Involved in gametogenesis and steroidogenesis. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.


FUNCTION: Releases the N-terminal proline from various substrates. SUBCELLULAR LOCATION: Cell envelope. SIMILARITY: Belongs to the peptidase S33 family.


FUNCTION: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. FUNCTION: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. SUBCELLULAR LOCATION: Secreted. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the NPY family.


FUNCTION: Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is a key enzyme involved in the production of lipoteichoic acid by reintroducing DAG formed from the breakdown of membrane phospholipids into the phosphatidylglycerol biosynthetic pathway. SIMILARITY: Belongs to the diacylglycerol/lipid kinase family.


FUNCTION: Does not inhibit strain RB-1 of the fish pathogen, infectious hematopoietic necrosis virus (IHNV). SUBCELLULAR LOCATION: Cytoplasm Note=Exhibits cytoplasmic staining in a large globular pattern surrounding the nucleus. SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


FUNCTION: The exact function of the plasmid-encoded citrate synthase is not clear, it could help nodulation by allowing the bacteria to use citrate as a chelator of iron and calcium. SIMILARITY: Belongs to the citrate synthase family.


FUNCTION: Protein-arginine rhamnosyltransferase that catalyzes the transfer of a single rhamnose to elongation factor P (EF-P) on 'Lys- 32', a modification required for EF-P-dependent rescue of polyproline stalled ribosomes. SIMILARITY: Belongs to the glycosyltransferase 104 family.


SIMILARITY: Belongs to the plectrovirus ORF4 family.


SIMILARITY: Belongs to the Ntn-hydrolase family.


FUNCTION: The terminase small subunit binds to the packaging initiation site and regulates the ATPase activity of the terminase large subunit. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer once the capsid is full (headful packaging). Once the capsid is packaged with the DNA, the terminase complex is substituted by neck proteins. SIMILARITY: Belongs to the P22likvirus small terminase family.


FUNCTION: Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.


FUNCTION: Involved in dorsal-ventral patterning. Appears to function predominantly as a ventralizing factor, through its actions as a BMP signaling agonist, acting through both chd-dependent and chd- independent mechanisms. May also antagonize BMP signaling, probably via formation of ternary complexes with chd and BMPs, resulting in dorsalization (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the twisted gastrulation protein family.


SIMILARITY: Belongs to the mimivirus L28/L54 family.


FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the alpha/beta interferon family.


SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the scoloptoxin-10 family.


FUNCTION: Involved in the degradation of triuret (carbonyldiurea), an impurity in agricultural urea fertilizer, and an intermediate of uric acid oxidation endogenously found in human urine and in prokaryotic metabolism. Catalyzes the hydrolysis of triuret to 1-carboxybiuret and ammonia. The product, carboxybiuret, channels into biuret metabolism and is spontaneously decarboxylated to biuret. Extremely specific for triuret with four, three and two orders of magnitude less activity with biuret, 1-nitrobiuret and formylurea, respectively. No activity with tetrauret, pentauret or nonplanar compounds methylene diurea or succinamide. SIMILARITY: Belongs to the isochorismatase family.


FUNCTION: Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. SIMILARITY: Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3.A.1.10) family.


SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: To E.coli AmpG and yeast YBR220c.


FUNCTION: Probable thiol-disulfide oxidoreductase that may be involved in the redox regulation of chloroplastic enzymes. SUBCELLULAR LOCATION: Plastid, chloroplast. SIMILARITY: Belongs to the thioredoxin family. Plant M-type subfamily.


FUNCTION: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the RecF family.


FUNCTION: Malate-sensitive anion transporter permeable to chloride, nitrate, sulfate and malate. Involved in dark-, CO(2)-, abscisic acid- and water-deficient-induced stomatal closure. Belongs to the R- type anion channels. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein Note=PubMed:20626656 indicates also a not confirmed endomembrane localization. SIMILARITY: Belongs to the aromatic acid exporter (TC 2.A.85) family.


FUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). SUBCELLULAR LOCATION: Nucleus, nucleolus Nucleus, Cajal body Note=Also localized to Cajal bodies (coiled bodies). SIMILARITY: Belongs to the GAR1 family.


SUBCELLULAR LOCATION: Secreted, extracellular space, apoplast. SIMILARITY: Belongs to the glycosyl hydrolase 35 family.


FUNCTION: The chloroplastic ME isoform decarboxylates malate shuttled from neighboring mesophyll cells. The CO(2) released is then refixed by ribulose-bisphosphate carboxylase. This pathway eliminates the photorespiratory loss of CO(2) that occurs in most plants (By similarity). SUBCELLULAR LOCATION: Plastid, chloroplast. SIMILARITY: Belongs to the malic enzymes family.


FUNCTION: Plays a central role in the packaging of viral DNA into phage procapsid, which occurs in the late stage of infection. The protein C can interact with the replicative complex composed of the protein A, the host rep and the viral DNA after the completion of one round of DNA synthesis. When protein C is bound to the replicative form, the complex becomes accessible to procapsid and serves as a DNA packaging apparatus. FUNCTION: C protein is one of the proteins involved in the production and packaging of viral single-stranded DNA. SIMILARITY: Belongs to the microviridae C protein family.


FUNCTION: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity). SUBCELLULAR LOCATION: Cytoplasm Cytoplasm, perinuclear region Endoplasmic reticulum. SIMILARITY: Belongs to the phosducin family.


FUNCTION: Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons. SUBCELLULAR LOCATION: Secreted.


FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Plays the major role in N- terminal methionine removal. Less efficient when the second residue is Val. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.


FUNCTION: Epimerizes UDP-galactose to UDP-glucose. SIMILARITY: Belongs to the polysaccharide synthase family.


FUNCTION: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. SUBCELLULAR LOCATION: Cytoplasm Membrane; Peripheral membrane protein Cell projection, dendritic spine Note=CTTNBP2-binding may regulate dendritic spine distribution. SIMILARITY: Belongs to the WD repeat striatin family.


FUNCTION: Plays an essential role in early embryonic development. SUBCELLULAR LOCATION: Nucleus, nucleolus.


FUNCTION: Probable Na(+)/H(+) antiporter. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.


FUNCTION: Key enzsyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate (By similarity). FUNCTION: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. SIMILARITY: Belongs to the FGGY kinase family.


SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SIMILARITY: Belongs to the FAM174 family.


FUNCTION: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.


FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. SIMILARITY: Belongs to the complex I 23 kDa subunit family.


FUNCTION: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. FUNCTION: Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling (PubMed:10465784). Plays a role in the activation of NF- kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs. Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression. Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion (By similarity). Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway (PubMed:14633973). Required for normal embryonic development (By similarity). SUBCELLULAR LOCATION: Cytoplasm Nucleus Mitochondrion. SIMILARITY: Belongs to the ECSIT family.


FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity). SUBCELLULAR LOCATION: Early endosome Recycling endosome Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity). SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.


FUNCTION: Terpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens (PubMed:21385377). Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to (1S,5S)-beta-pinene (PubMed:21385377). SUBCELLULAR LOCATION: Plastid, chloroplast. SIMILARITY: Belongs to the terpene synthase family. Tpsd subfamily.


FUNCTION: Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of KbaY. When expressed alone, KbaZ does not show any aldolase activity. SIMILARITY: Belongs to the GatZ/KbaZ family. KbaZ subfamily.


SIMILARITY: Belongs to the glycosyl hydrolase 15 family.


FUNCTION: Repressor of the galactose operon. Binds galactose as an inducer.


FUNCTION: Plus-end directed microtubule motor that may be used for anterograde axonal transport and could conceivably move cargos in fly neurons different than those moved by kinesin heavy chain or other plus-end directed motors. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.


FUNCTION: Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor Note=Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome. SIMILARITY: Belongs to the GOLIM4 family.


FUNCTION: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the DDI1 family.


SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: In the N-terminal section; belongs to the acetylglutamate kinase family. SIMILARITY: In the C-terminal section; belongs to the NAGSA dehydrogenase family.


SUBCELLULAR LOCATION: Synapse Cell membrane; Multi-pass membrane protein.


FUNCTION: Required for efficient mobilization of ColE1 plasmid and is thus essential to promote the specific transfer of the plasmid during conjugation. Probably functions by inducing DNA bending, helping the MbeA relaxase to melt the DNA around the nic site and cleave the phosphodiester bond. Binds specifically double-stranded DNA (dsDNA) containing the ColE1 oriT but does not recognize the inverted repeat (IR). SIMILARITY: To E.coli MbaC and MbkC.


FUNCTION: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. FUNCTION: With S5 and S12 plays an important role in translational accuracy. SIMILARITY: Belongs to the universal ribosomal protein uS4 family.


FUNCTION: Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB. SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.


FUNCTION: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of alpha- specific mating genes. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the MATALPHA1 family.


FUNCTION: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). SUBCELLULAR LOCATION: Mitochondrion Plastid, chloroplast. SIMILARITY: Belongs to the GatC family.


FUNCTION: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the ribose 5-phosphate isomerase family.


FUNCTION: Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue. SIMILARITY: Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.


FUNCTION: May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. SUBCELLULAR LOCATION: Cytoplasm. Early endosome. Mitochondrion. Note=Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner. SIMILARITY: Belongs to the milton family.


FUNCTION: PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.


FUNCTION: Reduces D-xylose into xylitol. Preferentially utilizes NADH as a cosubstrate. SIMILARITY: Belongs to the aldo/keto reductase family.


FUNCTION: E1-like enzyme which specifically catalyzes the second step in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.


FUNCTION: MFS-type transporter; part of the gene cluster that mediates the biosynthesis of pyranterreones, a family of antioxidative compounds (PubMed:32077283). Directly involved in the secretion of pyranterreones (PubMed:32077283). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.


FUNCTION: Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis. SIMILARITY: Belongs to the archaeal-type DHQ synthase family.


FUNCTION: Ubiquitin-like modifier involved in autophagosomes formation. Participates in membrane fusion events that take place in the secretory pathway (By similarity). SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. SIMILARITY: Belongs to the ATG8 family.


FUNCTION: Shows weak antimicrobial activity against its phylogenetic relative Caulobacter crescentus. Does not show activity against other bacteria tested (E.coli, Vibrio sp, Burkhoderia thailandensis, and Salmonella newport).


FUNCTION: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high- tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).


FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. SUBCELLULAR LOCATION: Secreted.


FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. Involved in vacuolar nutrient storage (e.g. accumulation and storage of nitrate) and in tolerance to some toxic ions (e.g. zinc ions sequestration in vacuoles). SUBCELLULAR LOCATION: Vacuole membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.


FUNCTION: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. SUBCELLULAR LOCATION: Cytoplasm, cytosol Cytoplasm Endoplasmic reticulum Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). SIMILARITY: Belongs to the eukaryotic ribosomal protein eL21 family.


FUNCTION: Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the type-III AFP family.


SIMILARITY: Belongs to the UPF0768 family.


SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.


FUNCTION: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity). SUBCELLULAR LOCATION: Secreted. Bacterial flagellum. SIMILARITY: Belongs to the FliD family.


FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. SIMILARITY: Belongs to the G protein gamma family.


FUNCTION: Major phosphoglucomutase isozyme that catalyzes the reversible interconversion of glucose 1-phosphate and glucose 6- phosphate (PubMed:5784209). Constitutes about 80-90% of the phosphoglucomutase activity in the cell (PubMed:14264884, PubMed:5231755). Key enzyme in hexose metabolism. The forward reaction is an essential step in the energy metabolism of galactose since the product of the galactose pathway enzymes in yeast is glucose 1- phosphate. The reverse reaction is an essential step for biosynthesis when carbon sources other than galactose are the energy source because glucose 1-phosphate is the starting point for the synthesis of UDP- glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose (PubMed:14264884). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the phosphohexose mutase family.


FUNCTION: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. SUBCELLULAR LOCATION: Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.


FUNCTION: Not known, symbiotically active.


FUNCTION: Involved in the inhibition of insect antibacterial peptides. Reduces the antibacterial activity of G.mellonella hemolymph by 50%. Reduces the antibacterial activity of cecropin A by 80% and cecropin B by 75%. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the peptidase M10B family.


FUNCTION: Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs to which the M1 protein is bound. Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enters the cytoplasm only when they have associated with the M1 protein that is necessary to guide them to the plasma membrane. May down- regulate viral RNA synthesis when overproduced (By similarity). SUBCELLULAR LOCATION: Virion Host nucleus. SIMILARITY: Belongs to the influenza viruses NEP family.


SIMILARITY: Belongs to the MQO family. SIMILARITY: Belongs to the MQO family.


FUNCTION: Specifically catalyzes the removal of N-terminal proline residues from peptides. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the peptidase S33 family.


FUNCTION: May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing. SUBCELLULAR LOCATION: Golgi apparatus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus speckle Endoplasmic reticulum membrane; Lipid-anchor Cell membrane; Lipid-anchor Cytoplasm Note=Localized in the brefeldin A- sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.


FUNCTION: [Gasdermin-like protein het-Q1, N-terminal]: Pore-forming protein that causes membrane permeabilization and cell death (PubMed:35135876). Released upon cleavage and maturation by het-Q2 and binds to membrane inner leaflet lipids (PubMed:35135876). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering cell death (By similarity). FUNCTION: [Gasdermin-like protein het-Q1]: Gasdermin-like protein involved in heterokaryon incompatibility, a process that ensures that during spontaneous vegetative cell fusion, only compatible cells from the same colony survive (non-self-recognition) (PubMed:35135876). In P.anserina, the het-q locus exists as 2 incompatible alleles, het-Q1 (this entry) and het-Q2 (AC P0DW09) (PubMed:35135876). This form constitutes the precursor of the pore-forming protein: during the allorecognition process, it is cleaved by het-Q2, releasing the N- terminal moiety (Gasdermin-like protein het-Q1, N-terminal) that binds to membranes and forms pores, triggering cell death (PubMed:35135876). SUBCELLULAR LOCATION: [Gasdermin-like protein het-Q1, N-terminal]: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the gasdermin family.


FUNCTION: Antimicrobial peptide. Has low activity against the Gram- positive bacterium S.aureus (MIC>100 uM) and the Gram-negative bacterium E.coli (MIC=25 uM). Lacks hemolytic activity against human erythrocytes. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.


FUNCTION: inhibits Kv1.3/KCNA3 channel. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 30 subfamily.


FUNCTION: Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity (PubMed:8606183, PubMed:9880556). Also negatively regulates the transcription of its own gene (PubMed:9880556). Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector (PubMed:9880556). FUNCTION: Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector.


FUNCTION: Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the venom Ptu1-like knottin family.


FUNCTION: Acts with RNA polymerase to initiate transcription from early gene promoters. Is recruited by the RPO-associated protein of 94 kDa RAP94/OPG109 to form the early transcription complex, which also contains the core RNA polymerase. ETF heterodimer binds to early gene promoters. SUBCELLULAR LOCATION: Virion Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle (By similarity). SIMILARITY: Belongs to the poxviridae VETF large subunit family.


FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:15860005). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. SIMILARITY: Belongs to the DDOST 48 kDa subunit family.


FUNCTION: Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity). SUBCELLULAR LOCATION: Virion Host nucleus Note=Anchored to the pentons, protrudes from the virion surface. SIMILARITY: Belongs to the adenoviridae fiber family.


FUNCTION: Probably necessary for the cotranslation of trpF. It may also function as a subunit or stabilizer of phosphoribosylanthranilate isomerase (trpF).


FUNCTION: Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates, using ATP, ITP or GTP as phosphate donor. SIMILARITY: Belongs to the carbohydrate kinase PfkB family.


FUNCTION: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta- barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. SIMILARITY: Belongs to the small Tim family.


FUNCTION: One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization. SUBCELLULAR LOCATION: Plastid, cyanelle thylakoid membrane; Single-pass membrane protein. SIMILARITY: Belongs to the PsbL family.


FUNCTION: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. FUNCTION: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. FUNCTION: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. SUBCELLULAR LOCATION: Cytoplasm. SUBCELLULAR LOCATION: Cytoplasm. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the L/F-transferase family. SIMILARITY: Belongs to the L/F-transferase family.


FUNCTION: May be involved in DNA replication. SUBCELLULAR LOCATION: Host nucleus. SIMILARITY: Belongs to the herpesviridae U79/UL112 family.


FUNCTION: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation. SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Single-pass membrane protein Note=The C-terminus is located in the stroma. SIMILARITY: Belongs to the TatB family.


FUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component srpra to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit srpra. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of srp9/srp14 and/or srp19 to stably interact with RNA (By similarity). SUBCELLULAR LOCATION: Cytoplasm Endoplasmic reticulum. SIMILARITY: Belongs to the GTP-binding SRP family. SRP54 subfamily.


FUNCTION: Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Essential for viability. Involved in glycosaminoglycan synthesis and the subsequent signaling. May be involved in hh and dpp signaling by controlling the sulfation of heparan sulfate (HS) (By similarity). SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.


FUNCTION: Required for DNA transformation (PubMed:1653215, PubMed:18761017). Positively regulates genes required for DNA transformation (late competence-specific genes) in association with CRP (PubMed:18761017). Required for expression of the dprABC operon (PubMed:9244270). SIMILARITY: Belongs to the TfoX family.


FUNCTION: Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the SEC62 family.


FUNCTION: Regulates the production of reactive oxygen species (ROS) by NADPH oxidase. SUBCELLULAR LOCATION: Membrane; Lipid-anchor. SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.


FUNCTION: Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity). SUBCELLULAR LOCATION: Nucleus Cytoplasm, perinuclear region Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization (By similarity).


FUNCTION: Facilitates the assembly of the membrane proton channel of the chloroplastic F-type ATPase. Specifically required for the efficient assembly and integration of the CF(0) subunit c into the chloroplastic ATPase complex in the thylakoid membrane. SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.


FUNCTION: Involved in cadmium/zinc transport. SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.


FUNCTION: Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. SUBCELLULAR LOCATION: Vacuole membrane; Lipid-anchor. SIMILARITY: Belongs to the beta-catenin family.


FUNCTION: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the secretoglobin family.


FUNCTION: Has anticoagulant activity, since it is able to inhibit the activation of coagulation factor X (F10) by coagulation factor VIIa (F7) (IC(50)=123.8 nM) (PubMed:27173146). Also shows weak irreversible neurotoxicity (PubMed:27173146). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain subfamily. Orphan group I sub-subfamily.


FUNCTION: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. FUNCTION: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the ABC1 family. UbiB subfamily.


FUNCTION: Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. SUBCELLULAR LOCATION: Nucleus, nucleolus.


FUNCTION: Component of the NF-Y/HAP transcription factor complex. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the NFYB/HAP3 subunit family.


FUNCTION: UstYa family oxidase, part of the gene cluster that mediates the biosynthesis of the secondary metabolite victorin, the molecular basis for Victoria blight of oats (PubMed:32929037). The role of vicYa within the pathway has still to be determined (PubMed:32929037). The pathway starts with the processing of the precursor vicA1 by several endopeptidases including kexin proteases as well as the cluster- specific S28 family peptidases vicPa and vicPb to produce 7 identical copies of the hexapeptide Gly-Leu-Lys-Leu-Ala-Phe. After being excised from the precursor peptide, the core peptides are cyclized and modified post-translationally by enzymes encoded within the gene cluster. The ustYa family oxidase vicYb is required for the formation of the macrocycle in victorin and the copper amine oxidases (CAOs) vicK1 and vicK2 are responsible for converting victorin to the active form by oxidizing the N-terminal glycyl residue in the peptides to glyoxylate. Relaxed substrate specificity of enzymes in the victorin biosynthetic pathway results in a metabolic grid that produces a set of analogs including victorinines B, C, E or HV-toxin M (Probable). SIMILARITY: Belongs to the ustYa family.


FUNCTION: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the URM1 family.


SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the teretoxin C (TC) superfamily.


FUNCTION: Probable transporter involved in the regulation of zinc homeostasis. SUBCELLULAR LOCATION: Cytoplasm Nucleus membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.


FUNCTION: Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles. SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. SIMILARITY: Belongs to the paramyosin family.


FUNCTION: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). SIMILARITY: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.


SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family. SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family.


FUNCTION: This is one of the chains of the nonenzymatic component (CF(0) subunit) of the mitochondrial ATPase complex. SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane protein. SIMILARITY: Belongs to the ATPase protein YMF19 family.


FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Seems to contribute to the inhibition of germination during stress (By similarity). SUBCELLULAR LOCATION: Nucleus Cytoplasm. SIMILARITY: Belongs to the peroxiredoxin family. Prx6 subfamily.


FUNCTION: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. FUNCTION: Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.


FUNCTION: Does not appear to play a major role in virulence (PubMed:31140968). May play a role in titan cell formation (PubMed:31140968). SIMILARITY: Belongs to the annexin family.


FUNCTION: Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction. SUBCELLULAR LOCATION: Virion Host cytoplasm. SIMILARITY: Belongs to the arenaviridae nucleocapsid protein family.


FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. SUBCELLULAR LOCATION: Cytoplasm Nucleus.


FUNCTION: Has a role in meiosis. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the unc-50 family.


FUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). SUBCELLULAR LOCATION: Secreted Cell membrane.


FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:3158524, PubMed:2953977). In addition, is involved in the utilization of D-sedoheptulose 7-phosphate, an intermediate of the pentose phosphate pathway, via the sedoheptulose bisphospate bypass pathway (PubMed:19756045). Catalyzes the phosphorylation of D- sedoheptulose 7-phosphate to D-sedoheptulose 1,7-bisphosphate (PubMed:19756045). FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. SUBCELLULAR LOCATION: Cytoplasm. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub- subfamily.


FUNCTION: Constant region of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). SUBCELLULAR LOCATION: Cell membrane.


FUNCTION: B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. SIMILARITY: Belongs to the pyridoxine kinase family. PdxK subfamily.


FUNCTION: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the SecD/SecF family. SecF subfamily.


FUNCTION: Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide. SUBCELLULAR LOCATION: Periplasm. SIMILARITY: Belongs to the NosZ family. SIMILARITY: In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.


FUNCTION: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD. Displays ATPase activity in vitro. FUNCTION: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity). SUBCELLULAR LOCATION: Cytoplasm. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the TsaE family.


FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the ARS2 family.


FUNCTION: Major structure protein of the hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. The hrp pilus functions as a conduit for protein delivery into the host cell (By similarity). SUBCELLULAR LOCATION: Secreted Fimbrium Note=Extracellular and secreted via type III secretion system. SIMILARITY: Belongs to the HrpA type 2 family.


SIMILARITY: Belongs to the coronaviruses NS4b protein family.


SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the gamma type-C retroviral envelope protein family.


FUNCTION: Shows very strong activity against S.aureus. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the invertebrate defensin family. Type 1 subfamily.


FUNCTION: RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing (By similarity). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (PubMed:11704680). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the splicing factor SR family.


FUNCTION: Hydroxymethylglutaryl-CoA synthase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). Erg13A and erg13B condense acetyl-CoA with acetoacetyl-CoA to form hydroxymethylglutaryl-CoA (HMG-CoA) (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase erg10B that catalyzes the formation of acetoacetyl- CoA. The hydroxymethylglutaryl-CoA synthases erg13A and erg13B then condense acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate- limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases hmg1 and hmg2. Mevalonate is also a precursor for the extracellular siderophore triacetylfusarinine C (TAFC) (PubMed:16110826, PubMed:22106303) (Probable). SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.


FUNCTION: Not required for motility. SIMILARITY: Belongs to the flagella basal body rod proteins family.


SIMILARITY: Belongs to the hemolysin E family.


FUNCTION: Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. SIMILARITY: Belongs to the MecA family.


FUNCTION: Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Has no activity towards L-amino acids or N-methyl-L-aspartic acid. May play a role in the egg-laying events and maturation processes of the reproductive organs. SUBCELLULAR LOCATION: Secreted, extracellular space. SIMILARITY: Belongs to the DAMOX/DASOX family.


SIMILARITY: Belongs to the UPF0303 family.


FUNCTION: RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (By similarity). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (By similarity). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification (PubMed:12851405) (Probable). Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre- ribosomal complexes (By similarity). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (By similarity). Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability (By similarity). SUBCELLULAR LOCATION: Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm, cytosol Mitochondrion. SIMILARITY: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.


FUNCTION: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H(2)O(2) in hyphae. May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early stage of plant infection. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the peroxidase family. Peroxidase/catalase subfamily.


FUNCTION: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.


FUNCTION: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.


FUNCTION: Member of the two-component regulatory system NatK/NatR that positively regulates the expression of the natAB operon. Acts by binding directly to the promoter of natAB. SUBCELLULAR LOCATION: Cytoplasm.


FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system, might be able to transport Fe(2+) into or out of the cell (Probable). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.


FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the Mediator complex subunit 20 family.


FUNCTION: Required for post-transcriptional gene silencing and natural virus resistance. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region Note=Accumulates in inclusion bodies in the cell periphery. May interact with the ER network from the perinuclear region out to the cell periphery (By similarity). SIMILARITY: Belongs to the SGS3 family.


SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.


FUNCTION: Quinolone epoxide rearrangement protein; part of the gene cluster that mediates the biosynthesis of penigequinolones, potent insecticidal alkaloids that contain a highly modified 10-carbon prenyl group (PubMed:25859931). The first stage is catalyzed by the nonribosomal pepdide synthetase penN that condenses anthranilic acid and O-methyl-L-tyrosine to produce 4'-methoxycyclopeptin (By similarity). 4'-methoxycyclopeptin is then converted to 4'- methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase penM through dehydrogenation to form a double bond between C-alpha and C-beta of the O-methyltyrosine side chain (By similarity). PenM also converts its first product methoxydehydrocyclopeptin to 4'- methoxycyclopenin (By similarity). The following conversion of 4'methoxycyclopenin into 4'-methoxyviridicatin is catalyzed by the cyclopenase penL (By similarity). 4'-methoxyviridicatin is the precursor of quinolone natural products, and is further converted to quinolinone B (Probable). The prenyltransferase penI then catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone, which is subjected to FAD- dependent dehydrogenation by the FAD-linked oxidoreductase penH to yield conjugated aryl diene (PubMed:25859931). The delta(3') double bond then serves as the site of the second alkylation with DMAPP catalyzed by the prenyltransferase penG to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain, or undergo cyclization to yield yaequinolones J1 and J2 (PubMed:25859931). The conversion of the styrenyl quinolone into the tetrahydrofuran-containing yaequinolone C is performed by the FAD-dependent monooxygenase penE and involves epoxidation of the terminal C7'-C8' olefin, followed by epoxide ring opening initiated by the C3' hydroxyl group (PubMed:25859931). The predicted cysteine hydrolase penJ acts as an epoxide hydrolase that enhances the rate of the 5-exo-tet cyclization step, increasing the yield of yaequinolone C (PubMed:25859931, PubMed:28114276). PenF catalyzes the cationic rearrangement of the epoxide formed by penE (before ring opening to produce yaequinolone C) into yaequinolone D (PubMed:28114276). Finally, the short-chain dehydrogenase/reductase (SDR)-like reductase penD, catalyzes both the dehydration of yaequinolone D and the reduction of the resulting oxonium to yield penigequinolone (PubMed:28114276). SIMILARITY: Belongs to the quinolone epoxide rearrangement protein penF family.


FUNCTION: Short-chain dehydrogenase/reductase; part of the core atranone cluster (CAC) which products are predicted to catalyze most or all steps of mycotoxin atranone synthesis, starting from geranylgeranyl pyrophosphate (GGPP) (PubMed:25015739). The initial cyclization of GGPP to dolabellane is probably performed by the terpene cyclase ATR13 (PubMed:25015739). The Baeyer-Villiger oxidation near the end of the atranone synthesis, which converts atranones D and E to atranones F and G is predicted to be catalyzed by the monooxygenase ATR8 (PubMed:25015739). Of the CAC's other predicted gene products, the reducing PKS ATR6 might synthesize a polyketide chain (PubMed:25015739). This polyketide is probably transferred onto the atranone backbone by the polyketide transferase ATR5 (By similarity). Other predicted CAC products include 4 oxygenases (ATR2, ATR3, ATR4, and ATR14), 3 short-chain reductases (ATR7, ATR9, and ATR10), and a methyltransferase (ATR12) (PubMed:25015739). These may all be involved in the various steps of atranone biosynthesis, although their specific roles must await experimental determination (PubMed:25015739). SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.


FUNCTION: Multifunctional regulator of fatty acid metabolism. SUBCELLULAR LOCATION: Cytoplasm.


FUNCTION: Involved in valine catabolism. SUBCELLULAR LOCATION: Peroxisome. SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.


FUNCTION: Involved in secondary cell wall cellulose deposition. Required for normal stem development (PubMed:20388664). May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). May be involved in the specific O-acetylation of cell wall polymers (By similarity). SUBCELLULAR LOCATION: Golgi apparatus membrane; Single- pass type II membrane protein. SIMILARITY: Belongs to the PC-esterase family. TBL subfamily.


FUNCTION: Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Very weakly suppress the acetylcholine (ACh)-evoked current mediated by alpha-7-similar nAChRs in L.stagnalis neurons. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.


FUNCTION: The function of this protein is currently unknown, but it has been shown that it is not necessary for phage resistance. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the UPF0177 family.


FUNCTION: Transports acetate. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


FUNCTION: [XK-related protein 9, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the XK family.


FUNCTION: Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the TorD/DmsD family. TorD subfamily.


FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. SUBCELLULAR LOCATION: Flagellar pocket. Cell membrane; Multi-pass membrane protein. Note=May be located in the flagellar pocket of the membrane. SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.


FUNCTION: Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the peptidase S1 family. CLIP subfamily.


FUNCTION: Seed storage protein (Probable). Globulin-like protein that acts as zinc metalloprotease. Cleaves specifically between Leu-15 and Tyr-16 of insulin B chain, and Gln-1 and Leu-2 of neurotensin (NT) peptide in vitro. May play a role as an initiating endopeptidase in germinating seeds (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the 7S seed storage protein family.


FUNCTION: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. SIMILARITY: Belongs to the EROs family.


FUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters (PubMed:11916968). Represses transcription from promoters with ATF sites (PubMed:11916968). It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the bZIP family. ATF subfamily.


SUBCELLULAR LOCATION: Mitochondrion. SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the AIM41 family.


FUNCTION: Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Single-pass membrane protein. SIMILARITY: Belongs to the YME2 family.


FUNCTION: A1b binds to basic 7S globulin (BG) and stimulates its phosphorylation activity.


FUNCTION: May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). SIMILARITY: Belongs to the Nudix hydrolase family.


FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. SIMILARITY: Belongs to the calreticulin family.


FUNCTION: Its major function may be to aid in digestion. SIMILARITY: Belongs to the peptidase S1 family.


FUNCTION: Required for normal heme biosynthesis. SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the TMEM14 family.


SIMILARITY: Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.


FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.


FUNCTION: Catalyzes the epimerization of dipeptides with L-Glu in the second position. Has epimerase activity with L-Gly-L-Glu, L-Ala-L-Glu, L-Ser-L-Glu, L-Pro-L-Glu, L-Val-L-Glu, L-Met-L-Glu, L-Thr-L-Glu and L- Phe-L-Glu (in vitro). SIMILARITY: Belongs to the mandelate racemase/muconate lactonizing enzyme family.


FUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytosol Cell membrane Endomembrane system. Note=Associated with membranes.


FUNCTION: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin- dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D- CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Plays an important role in controlling cell cycle progression and DNA damage- induced G2 arrest (PubMed:9106657). SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the CDI family.


FUNCTION: Plays an important role in the degradation of some oligopeptides. SUBCELLULAR LOCATION: Lysosome Cytoplasmic vesicle Secreted. SIMILARITY: Belongs to the peptidase S28 family.


FUNCTION: Required for the import and folding of small cysteine- containing proteins in the mitochondrial intermembrane space. SUBCELLULAR LOCATION: Mitochondrion intermembrane space Peroxisome matrix.


SIMILARITY: Belongs to the mannitol dehydrogenase family.


FUNCTION: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. SUBCELLULAR LOCATION: Plastid, chloroplast. Plastid, amyloplast. SIMILARITY: Belongs to the glycogen phosphorylase family.


SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.


FUNCTION: Catalyzes the isomerization of L-ribulose 5-phosphate to D- xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization. SIMILARITY: Belongs to the aldolase class II family. AraD/FucA subfamily.


FUNCTION: Involved in tumor formation and increases auxin and cytokinin effects in host plants.


FUNCTION: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression. SIMILARITY: Belongs to the LysR transcriptional regulatory family.


FUNCTION: Regulator of membrane trafficking. May be required for secretion of cell wall components in cells. SUBCELLULAR LOCATION: Early endosome membrane Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. SIMILARITY: Belongs to the small GTPase superfamily. Rab family.


FUNCTION: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.


FUNCTION: Selectively activates the mammalian capsaicin receptor TRPV1, a non-selective cation channel expressed by sensory neurons of the pain pathway. Is more potent than VaTx1, but less potent than VaTx3. Interacts with distinct regions of the channel than capsaicin, since it only acts on the extracellular face of the channel, and capsaicin binds to the cytosolic side. Also activates avian TRPV1, which is insensitive to capsaicin. Produce weak inhibition on potassium channels Kv2.1/KCNB1. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 62 (Vatx) subfamily.


FUNCTION: Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity). SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family.


FUNCTION: Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network Membrane, coated pit Note=Associated with the trans-Golgi network. SIMILARITY: Belongs to the adaptor complexes medium subunit family.


FUNCTION: Required for maintenance of normal mitochondrial morphology as well as PCP1-dependent processing of MGM1. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side Mitochondrion intermembrane space.