FUNCTION: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (By similarity). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (By similarity). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (By similarity). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (By similarity). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (By similarity). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light- dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). SUBCELLULAR LOCATION: [Isoform 2]: Rough endoplasmic reticulum Golgi apparatus Zymogen granule. SUBCELLULAR LOCATION: [Isoform 1]: Nucleus Nucleus envelope Cytoplasm Cytoplasm, cytoskeleton Note=Associated with microtubules. Localization at the nuclear envelope is TPR- dependent (By similarity).


FUNCTION: Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the IRF2BP family.


FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(3) position of a uridine in 25S rRNA. SUBCELLULAR LOCATION: Nucleus, nucleolus. SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase superfamily. BMT5 family.


FUNCTION: Vacuolar phosphate transporter that probably exports phosphate from the vacuolar lumen to the cytosol. SUBCELLULAR LOCATION: Vacuole membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the CitM (TC 2.A.11) transporter family.


SIMILARITY: Belongs to the UPF0357 family.


FUNCTION: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). SIMILARITY: Belongs to the uroplakin-3 family.


FUNCTION: Mediates resistance to pathogens which are sensitive to stilbenes. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.


FUNCTION: [Hexon-linking protein-C]: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together. FUNCTION: [Hexon-linking protein-N]: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together. SUBCELLULAR LOCATION: [Pre-hexon-linking protein VIII]: Host nucleus. SUBCELLULAR LOCATION: [Hexon-linking protein-N]: Virion Note=Located on the inner side of the capsid shell. Present in 120 copies per virion. SUBCELLULAR LOCATION: [Hexon-linking protein-C]: Virion Note=Located on the inner side of the capsid shell. Present in 120 copies per virion. SIMILARITY: Belongs to the adenoviridae hexon-linking protein family.


FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. FUNCTION: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:7628435, PubMed:33637724). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). SUBCELLULAR LOCATION: Midbody Late endosome Cytoplasmic vesicle, autophagosome Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). SIMILARITY: Belongs to the PI3/PI4-kinase family.


FUNCTION: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (By similarity). FUNCTION: Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139). SUBCELLULAR LOCATION: [Surface protein]: Cell membrane; Peripheral membrane protein Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. SUBCELLULAR LOCATION: Virion. SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane; Single-pass membrane protein. SIMILARITY: Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily.


FUNCTION: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 2 family.


SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the SLC35G solute transporter family.


FUNCTION: Might contribute to the loading of the ESCRT machinery. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. SIMILARITY: Belongs to the TOM1 family.


FUNCTION: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.


FUNCTION: Has a role in sporulation. SUBCELLULAR LOCATION: Cytoplasm.


FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. SIMILARITY: Belongs to the cytochrome c oxidase subunit 6B family.


FUNCTION: Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (By similarity). May also play a role in recruiting clathrin to endosomes (By similarity). May regulate growth factor-induced mitogenic signaling (By similarity). SIMILARITY: Belongs to the TOM1 family.


FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the NqrB/RnfD family.


SUBCELLULAR LOCATION: Plastid, chloroplast. SIMILARITY: Belongs to the bacterial ribosomal protein bL36 family. SIMILARITY: Belongs to the bacterial ribosomal protein bL36 family.


FUNCTION: Lysis proteins are required for both colicin release and partial cell lysis. SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor.


FUNCTION: ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the chloroplast. Required for the accumulation of TOC34, an essential component of the outer chloroplast membrane translocon (TOC) complex (PubMed:23167510, PubMed:28382961). Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to chloroplast, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis (PubMed:28382961). SUBCELLULAR LOCATION: Cytoplasm, cytosol. SIMILARITY: Belongs to the arsA ATPase family.


SUBCELLULAR LOCATION: Nucleus, nucleolus. Chromosome Note=Localizes to mitotic chromosomes in conjunction with MKI67.


FUNCTION: Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:19307175, PubMed:19666141). Plays a central role in the host erythrocytes and hepatocytes infection cycles, sexual reproduction and mosquito transmission of the parasite. During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK1 and CDPK5. Involved in merosome egress from host hepatocytes, probably together with CDPK5. During the asexual blood stage, involved in merozoite invasion of host erythrocytes and motility by stabilizing the inner membrane complex, a structure below the plasma membrane which acts as an anchor for the glidosome, an acto-myosin motor. Required for cell cycle progression in the male gametocyte. During male gametogenesis in the mosquito gut, required to initiate the first round of DNA replication, probably by facilitating the assembly of the pre- replicative MCM complex, to assemble the first mitotic spindle and, at the end of gametogenesis, to initiate axoneme motility, cytokinesis and subsequent exflagellation. For each of these steps, may phosphorylate SOC1, SOC2 and SOC3, respectively. Together with CDPK1, regulates ookinete gliding in the mosquito host midgut (By similarity). SUBCELLULAR LOCATION: Cytoplasm Cell membrane; Lipid-anchor. SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.


FUNCTION: Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:24442440). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:24442440). Exhibits a chemotactic activity for monocytes and lymphocytes but not neutrophils (PubMed:24442440). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the beta-microseminoprotein family.


FUNCTION: Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the frog skin active peptide (FSAP) family. Caerin subfamily.


FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Vital for female fertility. Required for learning/memory (By similarity). SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.


FUNCTION: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm (PubMed:2849541, PubMed:8499455, PubMed:23930894). This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP- hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex (PubMed:21711450). FUNCTION: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. SIMILARITY: Belongs to the KdpC family.


FUNCTION: DNA-dependent ATPase and 5'-3' DNA helicase (By similarity). Involved in the repair of replication forks and tolerance of the chain- terminating nucleoside analog 3' azidothymidine (AZT). May unwind potentially damaged 3' nascent ends such as those terminated by AZT, promote repair and AZT excision (PubMed:26544712). SIMILARITY: Belongs to the helicase family. DinG subfamily.


FUNCTION: Bifunctional O-glycosyltransferase and N-glycosyltransferase that can detoxify xenobiotics. Possesses high activity to metabolize the persistent pollutants 2,4,5-trichlorophenol (TCP) and 3,4- dichloroaniline (DCA). Also active on benzoates and benzoate derivatives in vitro. SIMILARITY: Belongs to the UDP-glycosyltransferase family.


FUNCTION: Phosphorylates thymidine and thymidine analogs, such as azidothymidine (AZT). Part of the salvage pathway for pyrimidine deoxyribonucleotide synthesis. SIMILARITY: Belongs to the thymidine kinase family.


SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the small heat shock protein (HSP20) family.


FUNCTION: Ferredoxins are iron-sulfur proteins that transfer electrons probably in the CO-dehydrogenase complex.


FUNCTION: Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available. SIMILARITY: Belongs to the RecJ family.


FUNCTION: Snake venom VEGFs that may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension. This protein induces an increase in capillary permeability after intradermal injection, as well as a drastic hypotensive effect after intravenous injection. The hypotension is mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase. Also induces angiogenesis in vitro, probably through VEGF receptor (KDR/VEGFR-2) signaling. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the PDGF/VEGF growth factor family. Snake venom VEGF subfamily.


FUNCTION: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post- transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis. SUBCELLULAR LOCATION: Mitochondrion matrix Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. SIMILARITY: Belongs to the pseudouridine synthase RluA family.


FUNCTION: Extracellular signaling peptide that represses primary root growth rate and significantly inhibits lateral root formation. Modulates leaf morphology (PubMed:24179096). Regulates systemic nitrogen (N)-demand signaling. Mediates up-regulation of genes involved in N uptake and assimilation pathways (PubMed:25324386). SUBCELLULAR LOCATION: [C-terminally encoded peptide 9.5]: Secreted, extracellular space, apoplast Note=Accumulates in xylem sap under nitrogen (N)-starved conditions. SUBCELLULAR LOCATION: [C-terminally encoded peptide 9.2]: Secreted, extracellular space, apoplast Note=Accumulates in xylem sap under nitrogen (N)-starved conditions. SUBCELLULAR LOCATION: [C-terminally encoded peptide 9.4]: Secreted, extracellular space, apoplast Note=Accumulates in xylem sap under nitrogen (N)-starved conditions. SUBCELLULAR LOCATION: [C-terminally encoded peptide 9.3]: Secreted, extracellular space, apoplast Note=Accumulates in xylem sap under nitrogen (N)-starved conditions. SUBCELLULAR LOCATION: [C-terminally encoded peptide 9.1]: Secreted, extracellular space, apoplast Note=Accumulates in xylem sap. SIMILARITY: Belongs to the C-terminally encoded plant signaling peptide (CEP) family.


FUNCTION: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes nodulisporic acids (NA). Nodulisporic acid A (NAA) and its chemically modified derivatives are of particular significance because of their highly potent insecticidal activity against blood-feeding arthropods and lack of observable adverse effects on mammals, in particular the tremogenicity associated with the paspaline-derived IDTs is not observed (PubMed:29283570). The geranylgeranyl diphosphate (GGPP) synthase ggs1, localized outside of the cluster, is proposed to catalyze the first step in nodulisporic acid biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:29283570). Condensation of indole-3- glycerol phosphate with GGPP by the prenyl transferase nodC then forms 3-geranylgeranylindole (3-GGI) (PubMed:29283570). Epoxidation by the FAD-dependent monooxygenase nodM leads to a single-epoxidized-GGI that is substrate of the terpene cyclase nodB for cyclization to yield emindole SB (PubMed:29283570). The terminal methyl carbon, C28, of emindole SB is then oxidized by the cytochrome P450 monooxygenase nodW to produce nodulisporic acid F (NAF), the pentacyclic core of NAA (PubMed:29283570). NAF is converted to nodulisporic acid E (NAE) via prenylation. This step is probably performed by one of the indole diterpene prenyltransferases nodD1 or nodD2 (Probable). Several oxidation steps performed by the FAD-linked oxidoreductase nodO and one of the cytochrome P450 monooxygenase nodR, nodX or nodZ further convert NAE to nodulisporic acid D (NAD) (Probable). NAD is substrate of cytochrome P450 monooxygenase nodJ to produce the precursor of nodulisporic acid C (NAC), converted to NAC by one of the indole diterpene prenyltransferases nodD1 or nodD2 (Probable). The FAD- dependent monooxygenase nodY2 then oxidizes NAC to nodulisporic acid B (NAB) (Probable). Finally NAB is converted to NAA by one of the cytochrome P450 monooxygenases nodR, nodX or nodZ (Probable). SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein. SIMILARITY: Belongs to the cytochrome P450 family.


SIMILARITY: Belongs to the ARG7 family.


FUNCTION: Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Displays a receptor-destroying activity which is a neuraminidate-O- acetyl esterase. This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell (By similarity). SUBCELLULAR LOCATION: Virion membrane; Single-pass type I membrane protein Host cell membrane; Single-pass type I membrane protein. SIMILARITY: Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.


FUNCTION: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein Note=Stabilized at the cell membrane through interaction with FCER1G. SIMILARITY: Belongs to the immunoglobulin superfamily. FCGR1 family.


FUNCTION: Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1 by interacting with the STAT1-binding region of host importins. Alternatively interacts also directly with host STAT1 and may additionally inhibit its non-phosphorylated form. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding. SUBCELLULAR LOCATION: Virion membrane; Peripheral membrane protein Host cell membrane; Peripheral membrane protein; Cytoplasmic side Host endomembrane system; Peripheral membrane protein Note=In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place (By similarity). SIMILARITY: Belongs to the filoviridae membrane-associated protein VP24 family.


FUNCTION: May help in the organization of the PsaE and PsaF subunits. SUBCELLULAR LOCATION: Plastid membrane; Single-pass membrane protein. SIMILARITY: Belongs to the PsaJ family.


FUNCTION: Involved in 6-O-carbamoylation of Nod-factors. SIMILARITY: Belongs to the NodU/CmcH family.


FUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis (By similarity). Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin (By similarity). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side Secreted, extracellular space, extracellular matrix. SIMILARITY: Belongs to the peptidase M10A family.


FUNCTION: Vacuolar membrane-localized H(+)-dependent K(+) and Na(+) transporter. SUBCELLULAR LOCATION: Vacuole membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/calcium exchanger (CCX) subfamily.


FUNCTION: Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction. SUBCELLULAR LOCATION: Cell projection, cilium Cytoplasm, cytoskeleton, cilium axoneme Note=Mainly present in locomotory and oral cilia.


FUNCTION: [Glucagon-like peptide 1]: Potent stimulator of glucose- dependent insulin release. Also stimulates insulin release in response to IL6. Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis. FUNCTION: [Glicentin]: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. FUNCTION: [Oxyntomodulin]: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. FUNCTION: [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. FUNCTION: [Glucagon-like peptide 2]: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. SUBCELLULAR LOCATION: Secreted. SUBCELLULAR LOCATION: [Glucagon-like peptide 1]: Secreted. SIMILARITY: Belongs to the glucagon family.


FUNCTION: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.


FUNCTION: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity). FUNCTION: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. SUBCELLULAR LOCATION: Plastid, chloroplast. SIMILARITY: Belongs to the bacterial ribosomal protein bL20 family. SIMILARITY: Belongs to the bacterial ribosomal protein bL20 family.


FUNCTION: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re- localizes to autophagosomes on autophagy activation.


SIMILARITY: Belongs to the peptidase M20 family.


FUNCTION: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. SUBCELLULAR LOCATION: Peroxisome. SIMILARITY: Belongs to the DAMOX/DASOX family.


FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein Nucleus, nucleolus Note=According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions.


FUNCTION: Secreted effector that completely suppresses the host cell death induced by cell death-inducing proteins. SUBCELLULAR LOCATION: Secreted Host nucleus. SIMILARITY: Belongs to the RxLR effector family.


FUNCTION: May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Colocalizes with PAPOLB in the endoplasmic reticulum. SIMILARITY: Belongs to the GSG1 family.


FUNCTION: Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl-pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the bacterial sugar transferase family.


FUNCTION: Involved in succinate export with YjjP. Both proteins are required for export. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the ThrE exporter (TC 2.A.79) family.


FUNCTION: Extracellular zinc metalloprotease. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the peptidase M4 family.


FUNCTION: The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis. FUNCTION: The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis. SUBCELLULAR LOCATION: Cellular chromatophore membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: Cellular chromatophore membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the reaction center PufL/M/PsbA/D family.


FUNCTION: May form an ATP-driven capsule polysaccharide export apparatus, in association with the VexA, VexB and VexC proteins. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the BexC/CtrB/KpsE family.


FUNCTION: Component of the DNA-directed RNA polymerase (RNAP) that catalyzes the transcription in the cytoplasm of viral DNA into RNA using the four ribonucleoside triphosphates as substrates. SUBCELLULAR LOCATION: Host cytoplasm Virion Note=Found in association with viral nucleoid. SIMILARITY: Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.


FUNCTION: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD- mediated CO oxidation. SIMILARITY: Belongs to the CdhB family.


FUNCTION: Involved in the organization of the outer spore wall layers and especially in the assembly of the chitosan layer. SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.


FUNCTION: May be involved in 20S pre-rRNA processing. SIMILARITY: Belongs to the TSR2 family.


FUNCTION: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. SIMILARITY: Belongs to the FAU-1 family.


FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the conotoxin M superfamily.


FUNCTION: Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. Plays a role in ciliogenesis by ubiquitinating OFD1. SUBCELLULAR LOCATION: Cytoplasm Cell membrane Endoplasmic reticulum membrane; Peripheral membrane protein Golgi apparatus membrane; Peripheral membrane protein Synapse Postsynaptic density Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus (By similarity). Expressed in the postsynaptic density region of synapses (By similarity). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane (By similarity).


FUNCTION: This excitatory toxin inhibits insect calcium-activated potassium (KCa) channels (Slo-type). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the neurotoxin 11 (kappa toxin) family.


FUNCTION: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. SUBCELLULAR LOCATION: Nucleus Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Note=Associates with the mitotic spindle and the kinetochore. Kinetochore association occurs only during mitosis. SIMILARITY: Belongs to the DASH complex DAM1 family.


FUNCTION: Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family.


FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex. Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity (By similarity). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). SUBCELLULAR LOCATION: Cytoplasm Cell membrane; Peripheral membrane protein; Cytoplasmic side Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.


SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. SIMILARITY: Belongs to the GPAT/DAPAT family. SIMILARITY: Belongs to the GPAT/DAPAT family.


FUNCTION: Carries out a dual function: signal transduction and activation of transcription (PubMed:29844444). Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. SUBCELLULAR LOCATION: Cytoplasm Nucleus Note=Translocated into the nucleus in response to phosphorylation. SIMILARITY: Belongs to the transcription factor STAT family.


SIMILARITY: Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.


FUNCTION: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. SIMILARITY: Belongs to the THEP1 NTPase family.


FUNCTION: Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI). SIMILARITY: Belongs to the PheA/TfdB FAD monooxygenase family.


FUNCTION: Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N- termini. Contributes to pathogenicity (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the peptidase S9C family.


FUNCTION: Participates in abscisic acid-regulated gene expression during seed development. Regulates the transcription of SGR1 and SGR2 that are involved in leaf and embryo degreening. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly found in the nucleus.


FUNCTION: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). SIMILARITY: Belongs to the ribonucleoside diphosphate reductase large chain family.


FUNCTION: MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel (By similarity). SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the MotA family.


FUNCTION: Transcription regulator of the gene cluster that mediates the biosynthesis of elsinochrome C, a perelyenequinone phytotoxin structurally similar to cercosporin. SUBCELLULAR LOCATION: Nucleus.


FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub- subfamily.


SUBCELLULAR LOCATION: Cell outer membrane. SIMILARITY: Belongs to the TrbG/VirB9 family.


FUNCTION: Together with P22, forms the internal part of the portal complex embeded in the virion internal membrane and which plays critical roles in genome packaging and genome ejection. Both proteins multimerize as a single ring-shaped heterdodecamer arranged around a central channel and interact with the P6/P9 external part of the portal. SUBCELLULAR LOCATION: Virion membrane; Single-pass membrane protein. Note=Part of the capsid inner membrane. Binds the portal complex at the capsid vertex.


FUNCTION: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.


FUNCTION: Is essential for plasmid replication. Nicks the positive strand at the plus origin of replication. SIMILARITY: Belongs to the Gram-positive plasmids replication protein type 2 family.


SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (PubMed:18493598). In addition to its role in the eIF-3 complex, also functions in protein ubiquitination and degradation (PubMed:18493598, PubMed:28505193). During mitosis required for regulating mitotic microtubule growth and kinetochore formation, and consequently is required for satisfying the spindle assembly checkpoint (SAC) during metaphase to prevent delays in mitotic progression (PubMed:28505193). This is likely by promoting the ubiquitination and degradation of Klp67A, a kinesin-like protein that suppresses microtubule polymerization at plus ends (PubMed:28505193). Acts in the COP9 signalosome (CSN) mediated regulation of cullin neddylation by promoting Cul1 and Cul3 neddylation and negatively regulating the CSN complex subunit CSN5 (PubMed:18493598). SUBCELLULAR LOCATION: Cytoplasm Microsome Endoplasmic reticulum Note=Uniformly distributed in interphase and mitotic cells. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the eIF-3 subunit E family.


FUNCTION: Involved in SarA attenuation. Affects resistance to oxacillin and teicoplanin, as well as the synthesis of virulence factors (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family.


FUNCTION: Together with the penton and the other minor capsid proteins (M1249L, p17), forms a complicated network immediately below the outer capsid shell, stabilizing the whole capsid (PubMed:31624094). Plays an essential role in the formation of infectious virus particles. Especially required for the formation of the capsid vertices (PubMed:17005638). During virion assembly, associates with the membrane and probably mediates the docking of the penton complex to the inner membrane, where it recruits the capsomers to form the penton core (PubMed:31624094). SUBCELLULAR LOCATION: Virion Note=Localizes in close proximity to the capsid vertices. SIMILARITY: Belongs to the asfivirus p49 structural protein family.


FUNCTION: Carboxypeptidase that preferentially hydrolyzes arginine and lysine residues at the C-terminus (PubMed:34750241). During infection by dengue virus, may play a role in preventing viral packaging, maturation, and release from the midgut (PubMed:25521592). SUBCELLULAR LOCATION: Endoplasmic reticulum. SIMILARITY: Belongs to the peptidase M14 family.


FUNCTION: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 1 is essential for cell cycle progression. It may associate with components of the DNA replication machinery and serve to enhance the efficiency of DNA replication. SUBCELLULAR LOCATION: Nucleus, nucleolus. SIMILARITY: Belongs to the activator 1 large subunit family.


SUBCELLULAR LOCATION: Plastid, chloroplast. SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.


FUNCTION: Mediates visceral muscle contractile activity (myotropic activity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the periviscerokinin family.


FUNCTION: Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex. Allophycocyanin has a maximum absorption at approximately 650 nanometers. SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side Note=Forms the core of the phycobilisome. SIMILARITY: Belongs to the phycobiliprotein family.


FUNCTION: Functions as a cellular zinc transporter. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein Nucleus Cytoplasm Golgi apparatus. SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.


SIMILARITY: Belongs to the cyclin family. Cyclin T subfamily.


FUNCTION: Plays a key role in hydrogen peroxide removal. SUBCELLULAR LOCATION: Peroxisome membrane; Single-pass membrane protein Note=Targets to peroxisomes and to a reticular compartment circulating the nucleus. SIMILARITY: Belongs to the peroxidase family. Ascorbate peroxidase subfamily.


FUNCTION: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in target proteins. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation (By similarity). Methylates ilf3 to regulate its DNA-binding activity (PubMed:18636753). Required for neural induction, playing a key role in the control of epidermal versus neural cell fate choice (PubMed:16214893). SUBCELLULAR LOCATION: Nucleus Nucleus, nucleoplasm Cytoplasm, cytosol Cytoplasm. SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: To B.subtilis YqeW.


FUNCTION: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). SIMILARITY: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.


FUNCTION: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (PubMed:12167700, PubMed:9864360, PubMed:23812376). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (By similarity). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX21 (PubMed:23812376). Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA (PubMed:12204379, PubMed:17451428). SUBCELLULAR LOCATION: Cytoplasm, cytosol Peroxisome Note=Cycles between the cytosol and the peroxisome. SIMILARITY: Belongs to the peroxin-21 family.


FUNCTION: Mitochondrial cysteine desulfurase, of the core iron-sulfur cluster (ISC) assembly complex, that catalyzes the desulfuration of L- cysteine to L-alanine, as component of the cysteine desulfurase complex, leading to the formation of a cysteine persulfide intermediate at the active site cysteine residue and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:25597503). The persulfide is then transferred on the flexible Cys loop from the catalytic site of NFS1 to the surface of NFS1 (By similarity). After the NFS1-linked persulfide sulfur is transferred to one of the conserved Cys residues of the scaffold, a reaction assisted by FXN (PubMed:25597503). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.


FUNCTION: May be involved in endocytosis. SIMILARITY: Belongs to the NECAP family.


FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:17178911). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:17178911). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton Nucleus. SIMILARITY: Belongs to the WD repeat ARPC1 family.


SIMILARITY: To M.jannaschii MJ1461.


FUNCTION: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single- pass type II membrane protein. SIMILARITY: Belongs to the glycosyltransferase 31 family.


FUNCTION: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the quinolinate synthase family. Type 3 subfamily.


SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.


FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. SUBCELLULAR LOCATION: Cytoplasm Note=May be associated with the plasma membrane. SIMILARITY: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.


FUNCTION: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:26047794, PubMed:8327470, PubMed:12324554, PubMed:20335586). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity). SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein Cell membrane; Multi-pass membrane protein Note=Localized at the brush border membranes of the proximal tubules. Internalized from the cell surface upon PTH stimulation. SIMILARITY: Belongs to the SLC34A transporter family.


FUNCTION: Methyltransferase that performs automethylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (By similarity). Controls the expression of the T-toxin gene cluster (PubMed:22383877). Promotes oxidative stress tolerance and acts as a virulence factors during infection (PubMed:22383877). Negatively regulate mycelial pigmentation and controls sexual development, as well as asexual development during vegetative growth (PubMed:22383877). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the methyltransferase superfamily. LaeA methyltransferase family.


FUNCTION: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF- 5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. SIMILARITY: Belongs to the deoxyhypusine hydroxylase family.


SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily. N- acyl-D-amino-acid deacylase family.


SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the histidine acid phosphatase family.


FUNCTION: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. FUNCTION: [Isoform 2]: Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase (PubMed:7476993). Does not undergo receptor internalization following ligand binding (PubMed:7476993). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 2 family.


FUNCTION: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the peptidase M17 family.


FUNCTION: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity). SUBCELLULAR LOCATION: Cytoplasm Mitochondrion. SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.


FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. SIMILARITY: Belongs to the TRAP-alpha family.


FUNCTION: Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. SUBCELLULAR LOCATION: Cytoplasm Endosome membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. SIMILARITY: Belongs to the sorting nexin family.


FUNCTION: Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1 family.


SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein. SIMILARITY: Belongs to the SMIM19 family.


FUNCTION: Relatively highly potent phospholipase A2 that displays potent antimicrobial and hemolytic activities. It does not show cytotoxic effects on the three human cell lines tested. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn- phosphoglycerides. It shows similar potencies on both Gram-negative and Gram-positive bacteria: B.cereus (MIC>9 ug/ml), B.subtilis (MIC>12 ug/ml), E.faecalis (MIC>7 ug/ml), S.epidermidis (MIC>12 ug/ml), S.aureux (MIC>5 ug/ml), E.coli (MIC>7 ug/ml), K.pneumonia (MIC>8 ug/ml), P.aeruginosa (MIC>10 ug/ml), and S.enteric (MIC>9 ug/ml). It also shows antifungal activities: A.niger (MIC>15 ug/ml), B.cinerea (MIC>12 ug/ml), F.solani (MIC>15 ug/ml), and P.digitatum (MIC>10 ug/ml). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the phospholipase A2 family. Group I subfamily.


FUNCTION: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the ALB/AFP/VDB family.


FUNCTION: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity). SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the Dus family. Dus3 subfamily.


SIMILARITY: Belongs to the PdaD family.


FUNCTION: May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. SUBCELLULAR LOCATION: Endomembrane system; Multi-pass membrane protein Note=May reside in an intracellular membrane-bound compartment. SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.


FUNCTION: Member of the two-component regulatory system MtrA/MtrB. FUNCTION: Member of the two-component regulatory system MtrA/MtrB. Binds direct repeat motifs of sequence 5'-GTCACAGCG-3', phosphorylation confers higher affinity. Overexpression decreases bacteria viability upon infection of human THP-1 macrophage cell line, due at least in part to impaired blockage of phagosome-lysosome fusion (upon infection bacteria usually remain in phagosomes). Infecting C57BL/6 mice with an overexpressing strain leads to an attentuated infection in both spleen and lungs. The level of dnaA mRNA increases dramatically. Binds the promoter of dnaA, fbpD, ripA and itself, as well as oriC, which it may regulate. Upon co-overexpression of MrtA and MtrB growth in macrophages is partially restored, dnaA expression is not induced, although mouse infections are still attenuated, suggesting that bacterial growth in macrophages requires an optimal ratio of MtrB to MtrA. SUBCELLULAR LOCATION: Cytoplasm. SUBCELLULAR LOCATION: Cytoplasm.


FUNCTION: RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation- dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Negative regulator of poly(A) synthesis. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation. REF2 is required for 3'-end formation of snoRNAs. SUBCELLULAR LOCATION: Nucleus.


FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein Postsynaptic cell membrane; Multi-pass membrane protein Basolateral cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.


FUNCTION: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and plays a role in neural development. SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the requiem/DPF family.


FUNCTION: Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes (By similarity). SIMILARITY: Belongs to the small GTPase superfamily. Rab family.


FUNCTION: Mitochondrial acetyl-CoA acetyltransferase that catalyzes both the formation and degradation of acetoacetyl-CoA (PubMed:32005728). Has no overlapping function with erg10B and seems not to be involved in ergosterol biosynthesis (PubMed:32005728). Plays an important role in growth, morphogenesis and maintaining mitochondrial function including the response to oxidative stresses (PubMed:32005728). SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.


FUNCTION: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. SUBCELLULAR LOCATION: Cell outer membrane. SIMILARITY: Belongs to the BamB family.


FUNCTION: ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.


FUNCTION: Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co- chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). SUBCELLULAR LOCATION: Cytoplasm, cytosol Endoplasmic reticulum Note=May transiently interact with the endoplasmic reticulum. SIMILARITY: Belongs to the AHA1 family.


FUNCTION: Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (PubMed:10520996). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (By similarity). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues (By similarity). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein; Extracellular side Melanosome Cytoplasm Note=Forms a complex with BST2 and localizes to the cytoplasm. SIMILARITY: Belongs to the peptidase M10A family.


FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Single-pass membrane protein. SIMILARITY: Belongs to the TIM21 family.


FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Single- pass type II membrane protein Cytoplasm, cytoskeleton. SIMILARITY: Belongs to the sarcoglycan beta/delta/gamma/zeta family.


SUBCELLULAR LOCATION: Spore core. SIMILARITY: Belongs to the SspK family.


SUBCELLULAR LOCATION: Vacuole. SIMILARITY: Belongs to the alliinase family.


FUNCTION: Catalyzes the transfer of electrons from NADPH to thioredoxins TRX1, TRX2 and TRX3, which in turn act as reductants of disulfide containing proteins (PubMed:9368022, PubMed:11013257, PubMed:16910770, PubMed:23845423). Able to reduce nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO); however, TRX1 is more efficient in reducing GSNO (PubMed:11013257). Has no catalytic activity towards oxidized glutathione (GSSG) (PubMed:11013257). SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.


FUNCTION: Baeyer-Villiger oxidase; part of the gene cluster that mediates the biosynthesis of pestheic acid, a diphenyl ether which is a biosynthetic precursor of the unique chloropupukeananes (PubMed:24302702). The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS ptaA (PubMed:24302702). As the ptaA protein is TE/CLC domain-deficient, hydrolysis and Claisen cyclization of the polyketide could be catalyzed by ptaB containing a beta-lactamase domain (PubMed:24302702). The ptaB protein might hydrolyze the thioester bond between the ACP of ptaA and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrated to form endocrocin anthrone (PubMed:24302702). Endocrocin anthrone is then converted to endocrocin, catalyzed by the anthrone oxygenase ptaC (PubMed:24302702). Spontaneous decarboxylation of endocrocin occurs to generate emodin (PubMed:24302702). An O- methyltransferase (ptaH or ptaI) could methylate emodin to form physcion (PubMed:24302702). PtaJ could then catalyze the oxidative cleavage of physcion, and rotation of the intermediate could then afford desmethylisosulochrin (PubMed:24302702). PtaF, a putative NADH- dependent oxidoreductase, might also participate in the oxidative cleavage step (PubMed:24302702). Desmethylisosulochrin is then transformed by another O-methyltransferase (ptaH or ptaI) to form isosulochrin (PubMed:24302702). Chlorination of isosulochrin by ptaM in the cyclohexadienone B ring then produces chloroisosulochrin (PubMed:24302702). PtaE is responsible for the oxidative coupling reactions of both benzophenones isosulouchrin and chloroisosulouchrin to RES-1214-1 and pestheic acid respectively, regardless of chlorination. SIMILARITY: Belongs to the questin oxidase family.


FUNCTION: Involved in EGFR signaling.


FUNCTION: Not known but it could act as a transmitter at neuromuscular synapses. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.


SIMILARITY: To M.leprae U650M.


FUNCTION: Major pilus subunit. Expressed only in pathogenic serotypes, it is part of myf, a probable virulence factor. SUBCELLULAR LOCATION: Fimbrium.


FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. SUBCELLULAR LOCATION: Nucleus Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body Note=Associated with kinetochores. SIMILARITY: Belongs to the SPC24 family.


FUNCTION: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). FUNCTION: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln) (By similarity). SIMILARITY: Belongs to the amidase family. GatA subfamily. SIMILARITY: Belongs to the amidase family. GatA subfamily.


FUNCTION: FanC is the main component of the K99 fimbriae. FUNCTION: Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs. SUBCELLULAR LOCATION: Fimbrium. SIMILARITY: Belongs to the fimbrial protein family.


FUNCTION: Specific inhibitor of store-operated non-voltage-gated calcium channels. SUBCELLULAR LOCATION: Secreted.


SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family.


FUNCTION: Binds directly to 23S rRNA. Might be involved in E site tRNA release (Potential). SUBCELLULAR LOCATION: Plastid, chloroplast. SIMILARITY: Belongs to the universal ribosomal protein uL1 family.


FUNCTION: Sterol-4-alpha-carboxylate 3-dehydrogenase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:12702354). ERG26 is a catalytic component of the C-4 demethylation complex that catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group (PubMed:12702354). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3- epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha- demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24- trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl- cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. SIMILARITY: Belongs to the 3-beta-HSD family.


FUNCTION: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. SIMILARITY: Belongs to the pyruvate kinase family.


FUNCTION: Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway. However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria. SUBCELLULAR LOCATION: Periplasm. SIMILARITY: Belongs to the cytochrome c family.


FUNCTION: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. SUBCELLULAR LOCATION: Cytoplasm, cytosol. SIMILARITY: Belongs to the GET4 family.


FUNCTION: Subunit 2 transfers the electrons from caldariella quinol to the bimetallic center of the catalytic subunit 1 that is formed by heme A3 and Cu(B). FUNCTION: The terminal oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein. SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.


FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PubMed:7608176). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (PubMed:7608176). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). SUBCELLULAR LOCATION: Early endosome membrane Recycling endosome membrane Cell membrane Nucleus Cytoplasm Postsynaptic density Note=Translocates to the plasma membrane upon EGF stimulation (By similarity). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (By similarity). SIMILARITY: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.


FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. May play a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side Cytoplasm. SIMILARITY: Belongs to the small GTPase superfamily. Ras family.


FUNCTION: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity). SIMILARITY: Belongs to the universal ribosomal protein uS7 family.


FUNCTION: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Chromosome, centromere, kinetochore Note=Translocates to the cytoplasm in the presence of STK3/MST2 and STK4/MST1.


FUNCTION: Major early eggshell protein. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the vitelline membrane family.


FUNCTION: Divalent metal transporter (PubMed:35700212). Can transport manganese (Mn) and iron (Fe) (PubMed:35700212). Involved in the release of metals stored in the vacuole (PubMed:35700212). SUBCELLULAR LOCATION: Vacuole membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the NRAMP (TC 2.A.55) family.


FUNCTION: Involved in cell division. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the CrgA family.


FUNCTION: Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms. SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the LOG family.


FUNCTION: Inhibits tax-6/calcineurin A phosphatase activity and thereby negatively regulates calcineurin-mediated functions (PubMed:12684004, PubMed:26232604, PubMed:27871170). Plays a role in modulating temperature-dependent calcium responses in AFD neurons and in addition, also negatively regulates thermotaxis in a tax-6-dependent manner in AFD neurons (PubMed:26232604). In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1 (PubMed:26232604). May play a role in regulating body size (PubMed:27871170). Plays a role in male tail tip morphogenesis (PubMed:21408209). SIMILARITY: Belongs to the RCAN family.


FUNCTION: Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side Mitochondrion outer membrane; Lipid-anchor; Cytoplasmic side. SIMILARITY: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


FUNCTION: Involved in mitochondrial genome encoded proteins translation. SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein mS37 family.


FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity). eS21 is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability (PubMed:14623272). SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the eukaryotic ribosomal protein eS21 family.


FUNCTION: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity. FUNCTION: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Synapse. Cell projection, dendritic spine. Cell projection, axon. Note=Partly colocalizes with stress fibers. Association with microtubules not observed in embryonic fibroblasts. In cultured hippocampal neurons, localizes to 54% of GABAergic and 25% of glutamatergic synapses. Frequently present at the base of dendritic protrusions and at the bifurcation points of the dendritic branches. Expressed at low levels in the axons of mature cultured hippocampal neurons. In embryonic fibroblasts, associated with actin stress fibers. SUBCELLULAR LOCATION: Cytoplasm Cytoplasm, cytoskeleton Synapse Cell projection, dendritic spine Cell projection, axon. SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the peptidase C14A family.


FUNCTION: May modulate protein synthesis. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein.


FUNCTION: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (By similarity). In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (By similarity). SUBCELLULAR LOCATION: Cytoplasm, perinuclear region Note=Concentrated in perinuclear structure. SIMILARITY: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. SIMILARITY: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. SIMILARITY: In the N-terminal section; belongs to the flavodoxin family.


FUNCTION: Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors (By similarity). SUBCELLULAR LOCATION: Virion Host rough endoplasmic reticulum membrane; Single-pass membrane protein; Lumenal side Note=Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles (By similarity). SIMILARITY: Belongs to the rotavirus VP7 family.


FUNCTION: There are several lipid A forms in this strain, including a phosphoethanolamine (1-O-P-pEtN) form; overexpression of this gene does not lead to higher levels of the 1-O-P-pEtN form of lipid A. SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the phosphoethanolamine transferase family.


FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike HS3ST1/3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein. SIMILARITY: Belongs to the sulfotransferase 1 family.


FUNCTION: Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome. SUBCELLULAR LOCATION: Nucleus Cytoplasm Note=Shuttles between the nucleus and the cytoplasm. SIMILARITY: Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.


FUNCTION: Antagonist of the C1 repressor or repressor bypass function.


FUNCTION: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the heparin-binding growth factors family.


FUNCTION: Probably involved in nervous system development and function. SIMILARITY: Belongs to the heparin-binding growth factors family.


FUNCTION: Plays an essential role in mitochondrial complex IV maturation and assembly. SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein Mitochondrion Mitochondrion inner membrane. SIMILARITY: Belongs to the PET100 family.


FUNCTION: Heterochronic protein which controls the choice of stage specific cell fates (PubMed:9054503, PubMed:6494891, PubMed:2702689, PubMed:2628162, PubMed:1916265, PubMed:7671811, PubMed:8625405, PubMed:8756295, PubMed:8756296, PubMed:9477318, PubMed:9649524, PubMed:10706289, PubMed:12871707, PubMed:15073154, PubMed:16139228). Regulates the timing of the second larval stage events (L2 events) in the hypodermis (PubMed:2702689, PubMed:2628162). May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3 (PubMed:10706289, PubMed:12871707, PubMed:16139228). Through this regulatory role, controls the timing of the sexual maturation of the nervous system (PubMed:31264582). Also has a role in the fox-1-sex-1-mediated determination of sexual fate (PubMed:21471153). Plays a role in governing the developmental timing of male tail tip morphogenesis (PubMed:26811380, PubMed:30956008). Plays a role in controlling the seam cell number during larval stages (PubMed:21471153, PubMed:28602583). Plays a role in vulval development (PubMed:28602583). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the lin-28 family.


FUNCTION: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post- transcriptional gene expression. SUBCELLULAR LOCATION: Mitochondrion Mitochondrion membrane; Multi-pass membrane protein.


FUNCTION: Transcriptional regulator that may regulate the expression of the loline biosynthesis cluster 1, one of the 2 clusters involved in the biosynthesis of loline alkaloids, potent insecticidal agents composed of a pyrrolizidine ring system and an uncommon ether bridge linking carbons 2 and 7 (PubMed:15654104). SUBCELLULAR LOCATION: Nucleus.


FUNCTION: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the UDPGP type 1 family.


FUNCTION: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). SIMILARITY: Belongs to the calmodulin family.


SIMILARITY: Belongs to the FAM154 family.


FUNCTION: Involved in degradation of indoleacetate, the most common member of the auxin class of plant hormones (PubMed:34059946). Catalyzes the irreversible oxidative decarboxylation of (2- aminobenzyl)malonyl-CoA to 2-aminocinnamoyl-CoA and CO(2) (Probable). In vitro, shows high catalytic efficiency with benzylmalonyl-CoA, a chemical analog of the physiological substrate, but otherwise accepts only a few medium-chain alkylmalonyl-CoA compounds as alternative substrates with low activities (PubMed:34059946). SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.


FUNCTION: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity). SIMILARITY: Belongs to the MinE family.


FUNCTION: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress (PubMed:26269648). Plays a role in spatial learning and motor coordination (PubMed:16504143). Involved in the nociceptive pain response to chemical-derived stimulation (PubMed:16729981). SUBCELLULAR LOCATION: Presynaptic cell membrane; Single-pass type I membrane protein. Perikaryon Cell projection, axon Note=Localizes to basket cell terminals and pinceaux.


FUNCTION: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasmic vesicle Cytoplasm, cytoskeleton Cytoplasm Nucleus Note=Enriched in selected actin structures.


FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity). FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. SIMILARITY: Belongs to the complex I 20 kDa subunit family.


FUNCTION: Kinesin that supports microtubule movement in an ATP- dependent manner and that functions as a minus-end directed motor as well as a plus-end tracking protein. During mitosis, is involved in early spindle assembly. Participates in the capture of antiparallel interpolar microtubules and helps in generating force to coalign microtubules. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, phragmoplast. Note=In interphase, is enriched specifically at growing microtubule plus-ends. In dividing cells, accumulates in spindle midzones and phragmoplast leading edges. SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.


FUNCTION: Binds actin. Enhances the F-actin depolymerization activity of actin-depolymerizing factor (ADF) proteins.


FUNCTION: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine. SIMILARITY: Belongs to the aspartokinase family.


FUNCTION: Exhibits ester hydrolase activity on the substrate p- nitrophenyl acetate. SUBCELLULAR LOCATION: Nucleus.


FUNCTION: Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein Early endosome membrane; Peripheral membrane protein Cytoplasmic vesicle, clathrin-coated vesicle.


FUNCTION: Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell. SUBCELLULAR LOCATION: Secreted Note=Secreted via the type III secretion system 1 (SPI-1 TTSS). SIMILARITY: Belongs to the phosphatase IpgD/SopB family.


FUNCTION: Cytosolic fumarate hydratase that catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:29688630). Catalyzes the dehydration of L-malate to fumarate in the cytosol: required for the massive fumarate accumulation during the day in plants grown under high nitrogen (PubMed:20202172). Also required for acclimation of photosynthesis to cold: acts by mediating accumulation of fumarate at low temperature, leading to reduce accumulation of phosphorylated sugars (PubMed:27440755). SUBCELLULAR LOCATION: Cytoplasm, cytosol. SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.


FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (By similarity). SUBCELLULAR LOCATION: Cytoplasm Nucleus. SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.


FUNCTION: Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism. SUBCELLULAR LOCATION: Secreted.


FUNCTION: This peptide is involved in the control mechanism of the synthesis of the macrolide-lincosamide-streptogramin B resistance protein.


FUNCTION: Acts upon elastin. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the peptidase S1 family. Elastase subfamily.


FUNCTION: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.