| { |
| "protocol": "split-first-v1", |
| "method": "additive", |
| "data_meta": { |
| "reference_fraction": 0.1, |
| "protocol": "split-first-v1", |
| "dataset": "norman", |
| "name": "norman", |
| "operation": "activation", |
| "control_label": "control", |
| "sep": "_", |
| "split": "perturbation", |
| "seed": 0, |
| "input_scale": "counts", |
| "raw_sha256": "21bd3c00b7f243d998aa9ca616490b45bf1b4ba9934d501190a867ddad982dae", |
| "raw_file": "norman_small.h5ad", |
| "n_cells": 920, |
| "n_control": 120, |
| "n_hvg": 201, |
| "n_pca": 10, |
| "pca_explained_var": 0.5626983046531677, |
| "mmd_gamma": 0.06974897265608301, |
| "fit_cell_ids_sha256": "5ff57f6222cd8d3e4dd6b7fa658c8599cf6eb4b553a607ad9100a7fc240f9f22", |
| "selection": { |
| "max_cells": null, |
| "max_per_group": null, |
| "max_groups": null |
| }, |
| "software": { |
| "scanpy": "1.12.4", |
| "anndata": "0.13.3.post0" |
| } |
| }, |
| "partition": "test", |
| "catalog": "all", |
| "reward": "cosine", |
| "seed": 0, |
| "n_controls": 8, |
| "query_cell_ids": [ |
| "CCTTCCCTCACTATTC", |
| "GTGGGTCAGTTAGCGG", |
| "CAGCTGGTCGAATGCT", |
| "ACAGCCGAGAGGGATA", |
| "GGTATTGCACAACTGT", |
| "ATGGGAGAGTCGAGTG", |
| "CTGCGGAGTCTTGCGG", |
| "GGCCGATGTATCACCA", |
| "CGATTGAGTCTAGGTT", |
| "TCTTTCCGTAGATTAG", |
| "GACGGCTCACCAGCAC", |
| "CAGCATAAGGCTAGCA", |
| "AACTCTTCATGGTAGG", |
| "AGCTCCTGTTCCTCCA", |
| "GCGCAGTAGGATTCGG", |
| "GTCTCGTGTGCATCTA", |
| "GGTGAAGTCAGGTAAA", |
| "CATTATCGTACTTAGC", |
| "TGCGTGGGTCTCATCC", |
| "CTGGTCTGTAGCGTGA", |
| "TCACAAGGTCACAAGG-1", |
| "GGCGACTCATTAGCCA", |
| "GGGAGATAGAAGGACA", |
| "GCGCCAACAGCCACCA", |
| "TACGGTAGTACTTCTT", |
| "CTCGAAAGTAGGCTGA", |
| "CAGCCGATCCTTGACC", |
| "GCTGCTTGTGAAAGAG", |
| "CGCTGGAGTACATGTC", |
| "GGCGACTCAGCTGTTA", |
| "GCGCAACGTTGAGGTG", |
| "CGGTTAAGTCAAAGCG", |
| "AGCAGCCGTTAAAGTG", |
| "TTAACTCCAGGGAGAG", |
| "ATCCGAATCTGCTGTC", |
| "ATCATGGAGGACGAAA", |
| "CTGATAGCACTCAGGC", |
| "AGCGGTCAGCACGCCT", |
| "GCGAGAATCAGGTTCA", |
| "CATTCGCCACCATGTA", |
| "TTCGAAGTCGATAGAA", |
| "AGAATAGCATTCCTGC", |
| "AGCGTCGCACAAGACG", |
| "AGGTCCGAGACTGTAA", |
| "TATTACCAGACACGAC", |
| "AAGGTTCCAGGAATCG", |
| "ATTGGACCAACAACCT", |
| "TGAGCCGGTCTCATCC", |
| "AGAGCGACAGCTGTAT", |
| "GGATTACCAAGTAATG", |
| "AGCGTATTCGCGTTTC", |
| "CGCTTCACAATCGGTT", |
| "GGTATTGAGTGGACGT", |
| "TAGTTGGGTTGGACCC", |
| "GTACTTTTCGTGGGAA", |
| "TTGCGTCGTTCGGCAC", |
| "GTACGTATCAACGCTA", |
| "TCGCGAGCACCTCGGA", |
| "AGCATACTCAGCTCGG", |
| "GCGCAACAGTGGGCTA-1", |
| "GGAGCAATCCTATTCA", |
| "GCACTCTTCAAACGGG", |
| "ATTACTCAGGATGTAT", |
| "CGACTTCTCCTTCAAT", |
| "TGAGCCGAGAGTCTGG", |
| "ACGAGCCTCGCATGGC-1", |
| "CCCATACCAGGTCCAC", |
| "CAGAGAGTCGTGGGAA", |
| "CGTTCTGAGATGCCAG-1", |
| "ATAACGCCAGGATCGA", |
| "TTTGCGCTCATTCACT-1", |
| "TTGGAACAGTGAACGC", |
| "CTCTGGTAGATATGCA", |
| "AGGTCCGTCGTCCGTT", |
| "CGTAGCGTCACGAAGG", |
| "CCGTACTTCGAATCCA", |
| "CTTAACTGTCTACCTC", |
| "AACACGTAGGAACTGC", |
| "TACACGATCCATTCTA", |
| "CAAGATCGTACGCACC-1", |
| "CTCGAGGGTGCGATAG", |
| "AAAGATGGTTGTCGCG-1", |
| "CTCCTAGCACAGCGTC", |
| "GATGCTAGTCATGCCG", |
| "TCGCGAGGTGACAAAT", |
| "CTACACCAGCGGCTTC", |
| "GCATACAAGACCACGA", |
| "CGCTATCCAAGCGAGT", |
| "GACGGCTGTCTAGTGT", |
| "GCATACATCGCCTGAG", |
| "ACATGGTGTTCCACGG", |
| "CGAGAAGCAAGCTGGA", |
| "GGGACCTGTACCATCA", |
| "TGGGAAGCAAACAACA", |
| "CCACGGAAGAGACTAT", |
| "ACGAGGACATGCTGGC", |
| "GTGCTTCAGGTGGGTT", |
| "TACAGTGGTAGGCATG", |
| "TCGTAGATCCACTCCA", |
| "TCAGCTCCACGTCTCT", |
| "GCTCCTAGTCGCTTCT-1", |
| "GCGAGAACAAATTGCC", |
| "TTGAACGCAGGATTGG", |
| "CGCCAAGCACGCCAGT", |
| "CAGCTGGTCAGTTCGA", |
| "GCCAAATAGTGCGTGA", |
| "TGACAACTCGTCGTTC", |
| "CAAGTTGTCGCCTGAG", |
| "GGAATAATCGACCAGC", |
| "TGTGTTTGTAGGAGTC", |
| "ACGAGCCAGCTAGTTC", |
| "ATGAGGGAGCCACCTG", |
| "CACAGGCGTTGCCTCT", |
| "GGAAAGCCACAGATTC", |
| "CGATGGCTCAAAGTAG", |
| "GTCTCGTAGCCAACAG", |
| "AGCATACCACGTTGGC", |
| "CACCACTCATCCAACA", |
| "CAGCAGCCACTGTGTA", |
| "CATTCGCCACGACTCG", |
| "GATCGATTCGCGGATC", |
| "GGGAGATAGACTTGAA", |
| "GTAGTCACAGGCAGTA", |
| "GACGGCTGTCCGAGTC", |
| "CAGCTAAAGCTACCGC", |
| "TGACAACGTCATACTG", |
| "ACTTACTCACCCTATC-1", |
| "TTTGCGCCAGCAGTTT", |
| "CACAGTACATCCGGGT", |
| "TGGCGCACATTTGCTT", |
| "ATGCGATGTGTCAATC", |
| "AGTGTCAAGATGAGAG", |
| "GTATTCTTCAGGCAAG", |
| "GTACTCCTCTGGTATG", |
| "GGTATTGGTTGTCGCG", |
| "CCTCAGTAGAGGTTAT", |
| "ACACCAAGTACCCAAT", |
| "TGGTTAGGTTGTTTGG", |
| "CTTAACTCAATAGAGT", |
| "ATTCTACTCAAGGCTT", |
| "CGGACGTAGTCATGCT", |
| "TCAATCTAGTATTGGA", |
| "GGGCACTGTTACAGAA", |
| "TTATGCTTCAGGCAAG" |
| ], |
| "guidance": { |
| "steps": 0, |
| "step_size": 0.5, |
| "k_nearest": 10, |
| "initialization": "best" |
| }, |
| "summary": { |
| "forward": { |
| "mse_expression": { |
| "mean": 0.046652437498931824, |
| "lower": 0.02089266203662375, |
| "upper": 0.0948633237920318, |
| "n": 4 |
| }, |
| "effect_pearson": { |
| "mean": 0.4207245574776526, |
| "lower": 0.34354994234431596, |
| "upper": 0.5323070546117004, |
| "n": 4 |
| }, |
| "effect_pearson_de20": { |
| "mean": 0.49355063698510215, |
| "lower": 0.35698437930087545, |
| "upper": 0.645778514526152, |
| "n": 4 |
| }, |
| "mmd2": { |
| "mean": 0.3279239168057454, |
| "lower": 0.19280990046670077, |
| "upper": 0.5196701367933856, |
| "n": 4 |
| }, |
| "sliced_wasserstein": { |
| "mean": 0.675569935161753, |
| "lower": 0.5024112240831669, |
| "upper": 0.9494201452287755, |
| "n": 4 |
| }, |
| "energy": { |
| "mean": 1.947377946808647, |
| "lower": 1.0853727559961297, |
| "upper": 3.2377672534953037, |
| "n": 4 |
| }, |
| "variance_ratio": { |
| "mean": 0.6377041554766198, |
| "lower": 0.42682685736634407, |
| "upper": 0.8629074132522487, |
| "n": 4 |
| } |
| }, |
| "inverse": { |
| "exhaustive": { |
| "top1": { |
| "mean": 0.0, |
| "lower": 0.0, |
| "upper": 0.0, |
| "n": 4 |
| }, |
| "top5": { |
| "mean": 0.25, |
| "lower": 0.0, |
| "upper": 0.75, |
| "n": 4 |
| }, |
| "ndcg10": { |
| "mean": 0.09671320180863541, |
| "lower": 0.0, |
| "upper": 0.2901396054259062, |
| "n": 4 |
| }, |
| "measured_reward": { |
| "mean": 0.523971751332283, |
| "lower": 0.3690347969532013, |
| "upper": 0.6616331934928894, |
| "n": 4 |
| }, |
| "measured_regret": { |
| "mean": 0.0650218278169632, |
| "lower": 0.006537541747093201, |
| "upper": 0.1680414378643036, |
| "n": 4 |
| }, |
| "selected_gene_overlap": { |
| "mean": 0.125, |
| "lower": 0.0, |
| "upper": 0.375, |
| "n": 4 |
| } |
| } |
| } |
| }, |
| "forward": [ |
| { |
| "target": "CEBPE_ZC3HAV1", |
| "query_cells": 8, |
| "genes_observed_in_training": false, |
| "mse_expression": 0.01953364688574133, |
| "effect_pearson": 0.5831659534659248, |
| "effect_pearson_de20": 0.7373505953543905, |
| "mmd2": 0.16240110360540805, |
| "sliced_wasserstein": 0.4700075250020136, |
| "energy": 0.9098931051185986, |
| "variance_ratio": 0.5182458249300406 |
| }, |
| { |
| "target": "CNN1", |
| "query_cells": 8, |
| "genes_observed_in_training": false, |
| "mse_expression": 0.02343294584700884, |
| "effect_pearson": 0.32709892549080255, |
| "effect_pearson_de20": 0.37106227204143644, |
| "mmd2": 0.25854713526372086, |
| "sliced_wasserstein": 0.5348149231643201, |
| "energy": 1.42617595324029, |
| "variance_ratio": 0.9777946093596515 |
| }, |
| { |
| "target": "HES7", |
| "query_cells": 8, |
| "genes_observed_in_training": false, |
| "mse_expression": 0.11867344977370611, |
| "effect_pearson": 0.3929029929048562, |
| "effect_pearson_de20": 0.3429064865603144, |
| "mmd2": 0.6067111373032738, |
| "sliced_wasserstein": 1.0876218859169273, |
| "energy": 3.8416310202469752, |
| "variance_ratio": 0.3354078898026477 |
| }, |
| { |
| "target": "PTPN12", |
| "query_cells": 8, |
| "genes_observed_in_training": true, |
| "mse_expression": 0.02496970748927101, |
| "effect_pearson": 0.3797303580490268, |
| "effect_pearson_de20": 0.5228831939842673, |
| "mmd2": 0.2840362910505789, |
| "sliced_wasserstein": 0.6098354065637508, |
| "energy": 1.6118117086287236, |
| "variance_ratio": 0.71936829781414 |
| } |
| ], |
| "inverse": [ |
| { |
| "target": "CEBPE_ZC3HAV1", |
| "search": "exhaustive", |
| "top1": 0.0, |
| "top5": 1.0, |
| "ndcg10": 0.38685280723454163, |
| "rank": 5, |
| "selected": "CEBPA_ZC3HAV1", |
| "predicted_reward": 0.7822824716567993, |
| "measured_reward": 0.6156078577041626, |
| "measured_regret": 0.0, |
| "selected_gene_overlap": 0.5, |
| "catalog_size": 20, |
| "candidate_cell_evaluations": 160, |
| "seconds": 2.702825076994486e-05, |
| "top_score_ties": 1 |
| }, |
| { |
| "target": "CNN1", |
| "search": "exhaustive", |
| "top1": 0.0, |
| "top5": 0.0, |
| "ndcg10": 0.0, |
| "rank": 12, |
| "selected": "IGDCC3", |
| "predicted_reward": 0.35028913617134094, |
| "measured_reward": 0.4857768416404724, |
| "measured_regret": 0.014822840690612793, |
| "selected_gene_overlap": 0.0, |
| "catalog_size": 20, |
| "candidate_cell_evaluations": 160, |
| "seconds": 2.702825076994486e-05, |
| "top_score_ties": 1 |
| }, |
| { |
| "target": "HES7", |
| "search": "exhaustive", |
| "top1": 0.0, |
| "top5": 0.0, |
| "ndcg10": 0.0, |
| "rank": 11, |
| "selected": "CEBPA_ZC3HAV1", |
| "predicted_reward": 0.5230290293693542, |
| "measured_reward": 0.28684377670288086, |
| "measured_regret": 0.2191143035888672, |
| "selected_gene_overlap": 0.0, |
| "catalog_size": 20, |
| "candidate_cell_evaluations": 160, |
| "seconds": 2.702825076994486e-05, |
| "top_score_ties": 1 |
| }, |
| { |
| "target": "PTPN12", |
| "search": "exhaustive", |
| "top1": 0.0, |
| "top5": 0.0, |
| "ndcg10": 0.0, |
| "rank": 15, |
| "selected": "ATL1", |
| "predicted_reward": 0.41614189743995667, |
| "measured_reward": 0.7076585292816162, |
| "measured_regret": 0.026150166988372803, |
| "selected_gene_overlap": 0.0, |
| "catalog_size": 20, |
| "candidate_cell_evaluations": 160, |
| "seconds": 2.702825076994486e-05, |
| "top_score_ties": 1 |
| } |
| ] |
| } |
