| { |
| "protocol": "split-first-v1", |
| "method": "ridge", |
| "data_meta": { |
| "reference_fraction": 0.1, |
| "protocol": "split-first-v1", |
| "dataset": "norman", |
| "name": "norman", |
| "operation": "activation", |
| "control_label": "control", |
| "sep": "_", |
| "split": "perturbation", |
| "seed": 0, |
| "input_scale": "counts", |
| "raw_sha256": "21bd3c00b7f243d998aa9ca616490b45bf1b4ba9934d501190a867ddad982dae", |
| "raw_file": "norman_small.h5ad", |
| "n_cells": 920, |
| "n_control": 120, |
| "n_hvg": 201, |
| "n_pca": 10, |
| "pca_explained_var": 0.5626983046531677, |
| "mmd_gamma": 0.06974897265608301, |
| "fit_cell_ids_sha256": "5ff57f6222cd8d3e4dd6b7fa658c8599cf6eb4b553a607ad9100a7fc240f9f22", |
| "selection": { |
| "max_cells": null, |
| "max_per_group": null, |
| "max_groups": null |
| }, |
| "software": { |
| "scanpy": "1.12.4", |
| "anndata": "0.13.3.post0" |
| } |
| }, |
| "partition": "test", |
| "catalog": "all", |
| "reward": "cosine", |
| "seed": 0, |
| "n_controls": 8, |
| "query_cell_ids": [ |
| "CCTTCCCTCACTATTC", |
| "GTGGGTCAGTTAGCGG", |
| "CAGCTGGTCGAATGCT", |
| "ACAGCCGAGAGGGATA", |
| "GGTATTGCACAACTGT", |
| "ATGGGAGAGTCGAGTG", |
| "CTGCGGAGTCTTGCGG", |
| "GGCCGATGTATCACCA", |
| "CGATTGAGTCTAGGTT", |
| "TCTTTCCGTAGATTAG", |
| "GACGGCTCACCAGCAC", |
| "CAGCATAAGGCTAGCA", |
| "AACTCTTCATGGTAGG", |
| "AGCTCCTGTTCCTCCA", |
| "GCGCAGTAGGATTCGG", |
| "GTCTCGTGTGCATCTA", |
| "GGTGAAGTCAGGTAAA", |
| "CATTATCGTACTTAGC", |
| "TGCGTGGGTCTCATCC", |
| "CTGGTCTGTAGCGTGA", |
| "TCACAAGGTCACAAGG-1", |
| "GGCGACTCATTAGCCA", |
| "GGGAGATAGAAGGACA", |
| "GCGCCAACAGCCACCA", |
| "TACGGTAGTACTTCTT", |
| "CTCGAAAGTAGGCTGA", |
| "CAGCCGATCCTTGACC", |
| "GCTGCTTGTGAAAGAG", |
| "CGCTGGAGTACATGTC", |
| "GGCGACTCAGCTGTTA", |
| "GCGCAACGTTGAGGTG", |
| "CGGTTAAGTCAAAGCG", |
| "AGCAGCCGTTAAAGTG", |
| "TTAACTCCAGGGAGAG", |
| "ATCCGAATCTGCTGTC", |
| "ATCATGGAGGACGAAA", |
| "CTGATAGCACTCAGGC", |
| "AGCGGTCAGCACGCCT", |
| "GCGAGAATCAGGTTCA", |
| "CATTCGCCACCATGTA", |
| "TTCGAAGTCGATAGAA", |
| "AGAATAGCATTCCTGC", |
| "AGCGTCGCACAAGACG", |
| "AGGTCCGAGACTGTAA", |
| "TATTACCAGACACGAC", |
| "AAGGTTCCAGGAATCG", |
| "ATTGGACCAACAACCT", |
| "TGAGCCGGTCTCATCC", |
| "AGAGCGACAGCTGTAT", |
| "GGATTACCAAGTAATG", |
| "AGCGTATTCGCGTTTC", |
| "CGCTTCACAATCGGTT", |
| "GGTATTGAGTGGACGT", |
| "TAGTTGGGTTGGACCC", |
| "GTACTTTTCGTGGGAA", |
| "TTGCGTCGTTCGGCAC", |
| "GTACGTATCAACGCTA", |
| "TCGCGAGCACCTCGGA", |
| "AGCATACTCAGCTCGG", |
| "GCGCAACAGTGGGCTA-1", |
| "GGAGCAATCCTATTCA", |
| "GCACTCTTCAAACGGG", |
| "ATTACTCAGGATGTAT", |
| "CGACTTCTCCTTCAAT", |
| "TGAGCCGAGAGTCTGG", |
| "ACGAGCCTCGCATGGC-1", |
| "CCCATACCAGGTCCAC", |
| "CAGAGAGTCGTGGGAA", |
| "CGTTCTGAGATGCCAG-1", |
| "ATAACGCCAGGATCGA", |
| "TTTGCGCTCATTCACT-1", |
| "TTGGAACAGTGAACGC", |
| "CTCTGGTAGATATGCA", |
| "AGGTCCGTCGTCCGTT", |
| "CGTAGCGTCACGAAGG", |
| "CCGTACTTCGAATCCA", |
| "CTTAACTGTCTACCTC", |
| "AACACGTAGGAACTGC", |
| "TACACGATCCATTCTA", |
| "CAAGATCGTACGCACC-1", |
| "CTCGAGGGTGCGATAG", |
| "AAAGATGGTTGTCGCG-1", |
| "CTCCTAGCACAGCGTC", |
| "GATGCTAGTCATGCCG", |
| "TCGCGAGGTGACAAAT", |
| "CTACACCAGCGGCTTC", |
| "GCATACAAGACCACGA", |
| "CGCTATCCAAGCGAGT", |
| "GACGGCTGTCTAGTGT", |
| "GCATACATCGCCTGAG", |
| "ACATGGTGTTCCACGG", |
| "CGAGAAGCAAGCTGGA", |
| "GGGACCTGTACCATCA", |
| "TGGGAAGCAAACAACA", |
| "CCACGGAAGAGACTAT", |
| "ACGAGGACATGCTGGC", |
| "GTGCTTCAGGTGGGTT", |
| "TACAGTGGTAGGCATG", |
| "TCGTAGATCCACTCCA", |
| "TCAGCTCCACGTCTCT", |
| "GCTCCTAGTCGCTTCT-1", |
| "GCGAGAACAAATTGCC", |
| "TTGAACGCAGGATTGG", |
| "CGCCAAGCACGCCAGT", |
| "CAGCTGGTCAGTTCGA", |
| "GCCAAATAGTGCGTGA", |
| "TGACAACTCGTCGTTC", |
| "CAAGTTGTCGCCTGAG", |
| "GGAATAATCGACCAGC", |
| "TGTGTTTGTAGGAGTC", |
| "ACGAGCCAGCTAGTTC", |
| "ATGAGGGAGCCACCTG", |
| "CACAGGCGTTGCCTCT", |
| "GGAAAGCCACAGATTC", |
| "CGATGGCTCAAAGTAG", |
| "GTCTCGTAGCCAACAG", |
| "AGCATACCACGTTGGC", |
| "CACCACTCATCCAACA", |
| "CAGCAGCCACTGTGTA", |
| "CATTCGCCACGACTCG", |
| "GATCGATTCGCGGATC", |
| "GGGAGATAGACTTGAA", |
| "GTAGTCACAGGCAGTA", |
| "GACGGCTGTCCGAGTC", |
| "CAGCTAAAGCTACCGC", |
| "TGACAACGTCATACTG", |
| "ACTTACTCACCCTATC-1", |
| "TTTGCGCCAGCAGTTT", |
| "CACAGTACATCCGGGT", |
| "TGGCGCACATTTGCTT", |
| "ATGCGATGTGTCAATC", |
| "AGTGTCAAGATGAGAG", |
| "GTATTCTTCAGGCAAG", |
| "GTACTCCTCTGGTATG", |
| "GGTATTGGTTGTCGCG", |
| "CCTCAGTAGAGGTTAT", |
| "ACACCAAGTACCCAAT", |
| "TGGTTAGGTTGTTTGG", |
| "CTTAACTCAATAGAGT", |
| "ATTCTACTCAAGGCTT", |
| "CGGACGTAGTCATGCT", |
| "TCAATCTAGTATTGGA", |
| "GGGCACTGTTACAGAA", |
| "TTATGCTTCAGGCAAG" |
| ], |
| "guidance": { |
| "steps": 0, |
| "step_size": 0.5, |
| "k_nearest": 10, |
| "initialization": "best" |
| }, |
| "summary": { |
| "forward": { |
| "mse_expression": { |
| "mean": 0.05169094726443291, |
| "lower": 0.018864271230995655, |
| "upper": 0.11335296230390668, |
| "n": 4 |
| }, |
| "effect_pearson": { |
| "mean": 0.33030068315565586, |
| "lower": 0.16261751018464565, |
| "upper": 0.4726503938436508, |
| "n": 4 |
| }, |
| "effect_pearson_de20": { |
| "mean": 0.3621273459866643, |
| "lower": 0.11420848872512579, |
| "upper": 0.572029322385788, |
| "n": 4 |
| }, |
| "mmd2": { |
| "mean": 0.3116877653178505, |
| "lower": 0.14812394201249968, |
| "upper": 0.5568990818097603, |
| "n": 4 |
| }, |
| "sliced_wasserstein": { |
| "mean": 0.6721777019807726, |
| "lower": 0.44711507913198856, |
| "upper": 1.0244874226229204, |
| "n": 4 |
| }, |
| "energy": { |
| "mean": 2.02961967352154, |
| "lower": 0.9207286089558822, |
| "upper": 3.81855959506595, |
| "n": 4 |
| }, |
| "variance_ratio": { |
| "mean": 0.6377041935920715, |
| "lower": 0.4268268942832947, |
| "upper": 0.8629074543714523, |
| "n": 4 |
| } |
| }, |
| "inverse": { |
| "exhaustive": { |
| "top1": { |
| "mean": 0.0, |
| "lower": 0.0, |
| "upper": 0.0, |
| "n": 4 |
| }, |
| "top5": { |
| "mean": 0.25, |
| "lower": 0.0, |
| "upper": 0.75, |
| "n": 4 |
| }, |
| "ndcg10": { |
| "mean": 0.19726620657947197, |
| "lower": 0.0, |
| "upper": 0.39453241315894394, |
| "n": 4 |
| }, |
| "measured_reward": { |
| "mean": 0.44576989859342575, |
| "lower": 0.33288320899009705, |
| "upper": 0.5641125068068504, |
| "n": 4 |
| }, |
| "measured_regret": { |
| "mean": 0.14322368055582047, |
| "lower": 0.04548661410808563, |
| "upper": 0.2409607470035553, |
| "n": 4 |
| }, |
| "selected_gene_overlap": { |
| "mean": 0.125, |
| "lower": 0.0, |
| "upper": 0.375, |
| "n": 4 |
| } |
| } |
| } |
| }, |
| "forward": [ |
| { |
| "target": "CEBPE_ZC3HAV1", |
| "query_cells": 8, |
| "genes_observed_in_training": false, |
| "mse_expression": 0.019093500450253487, |
| "effect_pearson": 0.49127334356307983, |
| "effect_pearson_de20": 0.5659799575805664, |
| "mmd2": 0.10966889005121061, |
| "sliced_wasserstein": 0.4153322269781998, |
| "energy": 0.7454481711569834, |
| "variance_ratio": 0.5182458758354187 |
| }, |
| { |
| "target": "CNN1", |
| "query_cells": 8, |
| "genes_observed_in_training": false, |
| "mse_expression": 0.018635042011737823, |
| "effect_pearson": 0.4540274441242218, |
| "effect_pearson_de20": 0.5780786871910095, |
| "mmd2": 0.18657899397378874, |
| "sliced_wasserstein": 0.4788979312857773, |
| "energy": 1.096009046754781, |
| "variance_ratio": 0.9777946472167969 |
| }, |
| { |
| "target": "HES7", |
| "query_cells": 8, |
| "genes_observed_in_training": false, |
| "mse_expression": 0.14477278292179108, |
| "effect_pearson": 0.06548086553812027, |
| "effect_pearson_de20": -0.036382000893354416, |
| "mmd2": 0.6803391110884176, |
| "sliced_wasserstein": 1.2063505864019681, |
| "energy": 4.726076444503006, |
| "variance_ratio": 0.33540791273117065 |
| }, |
| { |
| "target": "PTPN12", |
| "query_cells": 8, |
| "genes_observed_in_training": true, |
| "mse_expression": 0.02426246367394924, |
| "effect_pearson": 0.31042107939720154, |
| "effect_pearson_de20": 0.34083274006843567, |
| "mmd2": 0.27016406615798494, |
| "sliced_wasserstein": 0.5881300632571452, |
| "energy": 1.55094503167139, |
| "variance_ratio": 0.7193683385848999 |
| } |
| ], |
| "inverse": [ |
| { |
| "target": "CEBPE_ZC3HAV1", |
| "search": "exhaustive", |
| "top1": 0.0, |
| "top5": 1.0, |
| "ndcg10": 0.5, |
| "rank": 3, |
| "selected": "CEBPA_ZC3HAV1", |
| "predicted_reward": 0.7371546030044556, |
| "measured_reward": 0.6156078577041626, |
| "measured_regret": 0.0, |
| "selected_gene_overlap": 0.5, |
| "catalog_size": 20, |
| "candidate_cell_evaluations": 160, |
| "seconds": 0.00017801774993131403, |
| "top_score_ties": 1 |
| }, |
| { |
| "target": "CNN1", |
| "search": "exhaustive", |
| "top1": 0.0, |
| "top5": 0.0, |
| "ndcg10": 0.2890648263178879, |
| "rank": 10, |
| "selected": "KLF1_MAP2K6", |
| "predicted_reward": 0.25235575437545776, |
| "measured_reward": 0.40962645411491394, |
| "measured_regret": 0.09097322821617126, |
| "selected_gene_overlap": 0.0, |
| "catalog_size": 20, |
| "candidate_cell_evaluations": 160, |
| "seconds": 0.00017801774993131403, |
| "top_score_ties": 1 |
| }, |
| { |
| "target": "HES7", |
| "search": "exhaustive", |
| "top1": 0.0, |
| "top5": 0.0, |
| "ndcg10": 0.0, |
| "rank": 12, |
| "selected": "CEBPA_ZC3HAV1", |
| "predicted_reward": 0.495243102312088, |
| "measured_reward": 0.28684377670288086, |
| "measured_regret": 0.2191143035888672, |
| "selected_gene_overlap": 0.0, |
| "catalog_size": 20, |
| "candidate_cell_evaluations": 160, |
| "seconds": 0.00017801774993131403, |
| "top_score_ties": 1 |
| }, |
| { |
| "target": "PTPN12", |
| "search": "exhaustive", |
| "top1": 0.0, |
| "top5": 0.0, |
| "ndcg10": 0.0, |
| "rank": 13, |
| "selected": "KLF1_MAP2K6", |
| "predicted_reward": 0.3569853901863098, |
| "measured_reward": 0.4710015058517456, |
| "measured_regret": 0.2628071904182434, |
| "selected_gene_overlap": 0.0, |
| "catalog_size": 20, |
| "candidate_cell_evaluations": 160, |
| "seconds": 0.00017801774993131403, |
| "top_score_ties": 1 |
| } |
| ] |
| } |
