Instructions to use MedMLX/lesiondiffusion-mlx with libraries, inference providers, notebooks, and local apps. Follow these links to get started.
- Libraries
- MLX
How to use MedMLX/lesiondiffusion-mlx with MLX:
# Download the model from the Hub pip install huggingface_hub[hf_xet] hf download MedMLX/lesiondiffusion-mlx --local-dir lesiondiffusion-mlx
- Notebooks
- Google Colab
- Kaggle
- Local Apps Settings
- LM Studio
- Atomic Chat
Add native MLX model card and conversion guide
Browse files
README.md
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---
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library_name: mlx
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license: other
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tags:
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- medical-imaging
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- apple-silicon
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- research
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- inference
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- conversion
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- model-card-only
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language:
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- en
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license_name: upstream-component-terms
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license_link: https://github.com/HengruiTianSJTU/LesionDiffusion
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pipeline_tag: image-to-image
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---
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# LesionDiffusion for MLX
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Native MLX LesionDiffusion synthesis on Apple Silicon using LMNet, LINet, and VQ components. The recorded paper configuration inserts a liver tumor into a prepared CT crop; current conditioned inference is documented separately below.
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**Repository contents:** model card and local conversion instructions. No checkpoint, tokenizer, medical image, or output data is included. Obtain original assets directly from their publishers under the applicable terms.
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Requires an Apple Silicon Mac with Metal and Python 3.12/3.13. Model inference uses MLX; PyTorch is used for one-time checkpoint conversion and optional upstream comparisons. Intended for research and education; clinical diagnostic performance has not been established.
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Native MLX package: [lesiondiffusion-mlx](https://github.com/MedMLX/lesiondiffusion-mlx).
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Evaluated revision: `9b7a15eef808a38ab56e82325c22f209f69b9b78`.
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This card describes the one configuration evaluated in the MedMLX paper. It is research software; the single-case comparison does not estimate clinical accuracy.
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## Source and checkpoint
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Original publisher: HengruiTianSJTU.
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Original implementation: [https://github.com/HengruiTianSJTU/LesionDiffusion](https://github.com/HengruiTianSJTU/LesionDiffusion).
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Source revision or version: `880736e2b8a4d9becdb6594da7f8af6db19d04d1`.
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Original checkpoint: Component locations are in the native run record and the upstream package documentation.
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Conversion: lesiondiffusion_mlx.write_conversion (README recipe), using the upstream component checkpoints and an explicitly supplied BiomedCLIP tokenizer.
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Conversion changes tensor layout or storage as specified by the native package; it does not retrain the model.
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## Install and convert
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Install the native package with conversion support:
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```bash
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uv pip install "lesiondiffusion-mlx[conversion] @ git+https://github.com/MedMLX/lesiondiffusion-mlx.git"
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```
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Obtain the LMNet, LINet, and VQ checkpoints through the [official upstream project](https://github.com/HengruiTianSJTU/LesionDiffusion), together with its BiomedCLIP `tokenizer.json`. Component terms remain separate. Convert the explicitly selected local assets:
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```python
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from pathlib import Path
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from lesiondiffusion_mlx import write_conversion
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write_conversion(
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checkpoints={
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"lmnet": Path("LMNet.ckpt"),
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"linet": Path("LINet.ckpt"),
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"vq": Path("VQ.ckpt"),
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},
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tokenizer_path=Path("tokenizer.json"),
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output_dir=Path("lesiondiffusion"),
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)
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```
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The [package README](https://github.com/MedMLX/lesiondiffusion-mlx#input-and-output) defines the CT and organ-mask preparation contract. The example below explicitly selects the paper's `source` inference mode. The package currently defaults to `conditioned`; its source-parity result must not be applied to that mode.
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## Recorded example
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AMOS22 (validation) / amos_0008; AMOS22 (validation) / amos_0008 label 6 (liver)
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```python
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from lesiondiffusion_mlx.medmlx import run
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# Replace file and directory names with your locally obtained inputs and weights.
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kwargs = {
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"image_path": "amos_0008_ct_1mm_ras_160x160x128.nii.gz",
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"organ_mask_path": "amos_0008_liver_1mm_ras_160x160x128.nii.gz",
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"output_dir": "out",
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"weights_path": "lesiondiffusion",
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"organ": "liver",
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"lesion_type": "tumor",
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"bbox_size_mm": [
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30,
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30,
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20
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],
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"placement": "inside_parenchyma",
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"inference_mode": "source",
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"diffusion_steps": 200,
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"overwrite": False,
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"seed": 23
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}
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result = run(**kwargs)
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print(result["outputs"])
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```
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Native result: **success**. Original-code comparison: **pass**, `cosine_similarity` = `0.9999697715207947`.
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Full controlled 200-step paired reference completed October 12; image cosine 0.99996977 and lesion Dice 1.0. Density and outside-lesion reconstruction limitations remain.
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The complete [native run](https://github.com/MedMLX/Med-MLX/blob/main/results/runs/lesiondiffusion.json) and [original-code comparison](https://github.com/MedMLX/Med-MLX/blob/main/results/reference/lesiondiffusion.json) retain commands, geometry, precision, and output-specific checks. Use the [replay harness](https://github.com/MedMLX/Med-MLX/blob/main/benchmarks/README.md) to substitute local paths. The package README documents installation and conversion.
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The current package defaults to `inference_mode="conditioned"`, which enables LINet text context and native FP16 convolution. The example above explicitly selects `source` to retain the paper's evaluated mode. The [October 12 follow-up](https://github.com/MedMLX/Med-MLX/blob/main/results/lesiondiffusion-conditioned-20261012.json) records a 452.6 s 200-step run with −20.6 HU lesion-minus-nearby-liver contrast and a 128.4 s 50-step draw with −19.0 HU contrast on the same case. This additional visibility check does not extend the paper's source-parity result to conditioned mode or establish clinical validity.
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## Distribution terms
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Upstream code: **MIT**. Weights: **Unresolved; retrieve directly from the original publisher**.
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Eligible route: **converter**. Prepared locally; no converted weights uploaded.
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Full controlled 200-step paired reference completed October 12; image cosine 0.99996977 and lesion Dice 1.0. Density and outside-lesion reconstruction limitations remain. No unambiguous complete-component redistribution grant verified; distribute conversion code and refer users to the original weights.
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Required notices:
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- Retain the applicable license, copyright and attribution notices; identify the upstream checkpoint, authors, and MLX conversion changes.
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Review sources:
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- https://github.com/HengruiTianSJTU/LesionDiffusion
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