| import os |
|
|
|
|
| def get_information(length): |
| if length < 60: |
| return { |
| "AF2_ipae": [3.84, 5.03, 6.07, 6.12, 21.36, 10.57, 8.75, 8.24, 23.1, 15.32], |
| "ptx_iptm": [ |
| 0.95, |
| 0.9, |
| 0.83, |
| 0.64, |
| 0.54, |
| 0.49, |
| 0.89, |
| 0.67, |
| 0.28, |
| 0.1, |
| ], |
| "ptx_temp_iptm": [ |
| 0.95, |
| 0.91, |
| 0.87, |
| 0.84, |
| 0.44, |
| 0.6, |
| 0.88, |
| 0.58, |
| 0.68, |
| 0.35, |
| ], |
| "AF2_SR": [44.89, 37.5, 28.41, 19.6, 3.12, 10.23, 26.42, 13.92, 0.28, 5.68], |
| "ptx_sr": [55.7, 32.4, 11.9, 3.1, 2.3, 0.3, 33.0, 3.7, 0.0, 0.0], |
| "ptx_temp_sr": [58.5, 50.0, 17.0, 15.9, 0.6, 0.0, 31.2, 0.6, 1.1, 0.0], |
| "count": "Length 50-60", |
| } |
| elif length < 80 and length >= 60: |
| return { |
| "AF2_ipae": [3.99, 4.97, 5.73, 6.37, 17.19, 9.37, 8.83, 8.04, 22.71, 16.09], |
| "ptx_iptm": [ |
| 0.94, |
| 0.9, |
| 0.88, |
| 0.59, |
| 0.58, |
| 0.52, |
| 0.88, |
| 0.76, |
| 0.33, |
| 0.09, |
| ], |
| "ptx_temp_iptm": [ |
| 0.95, |
| 0.91, |
| 0.88, |
| 0.86, |
| 0.54, |
| 0.58, |
| 0.88, |
| 0.66, |
| 0.71, |
| 0.36, |
| ], |
| "AF2_SR": [ |
| 44.79, |
| 44.35, |
| 33.93, |
| 20.39, |
| 5.65, |
| 13.39, |
| 28.87, |
| 19.49, |
| 0.74, |
| 6.55, |
| ], |
| "ptx_sr": [54.6, 36.6, 16.5, 2.8, 2.2, 0.1, 33.5, 7.1, 0.0, 0.0], |
| "ptx_temp_sr": [62.5, 45.2, 22.0, 19.6, 0.9, 0.0, 37.5, 3.9, 3.9, 0.0], |
| "count": "Length 60-80", |
| } |
| elif length < 100 and length >= 80: |
| return { |
| "AF2_ipae": [4.03, 5.08, 5.58, 6.12, 14.36, 8.87, 9.79, 7.96, 22.57, 16.02], |
| "ptx_iptm": [ |
| 0.94, |
| 0.88, |
| 0.86, |
| 0.56, |
| 0.64, |
| 0.51, |
| 0.87, |
| 0.82, |
| 0.33, |
| 0.09, |
| ], |
| "ptx_temp_iptm": [ |
| 0.96, |
| 0.9, |
| 0.88, |
| 0.87, |
| 0.61, |
| 0.59, |
| 0.88, |
| 0.71, |
| 0.72, |
| 0.37, |
| ], |
| "AF2_SR": [49.4, 45.09, 38.24, 21.28, 6.55, 15.18, 16.22, 23.51, 0.6, 4.91], |
| "ptx_sr": [59.4, 30.2, 18.9, 2.1, 3.6, 0.0, 24.4, 9.1, 0.0, 0.0], |
| "ptx_temp_sr": [70.5, 43.5, 23.2, 26.5, 1.8, 0.0, 29.2, 6.2, 5.4, 0.0], |
| "count": "Length 80-100", |
| } |
| elif length < 120 and length >= 100: |
| return { |
| "AF2_ipae": [ |
| 4.08, |
| 5.28, |
| 5.69, |
| 6.73, |
| 12.75, |
| 8.38, |
| 10.29, |
| 8.06, |
| 22.85, |
| 13.73, |
| ], |
| "ptx_iptm": [ |
| 0.94, |
| 0.88, |
| 0.84, |
| 0.44, |
| 0.6, |
| 0.54, |
| 0.85, |
| 0.84, |
| 0.26, |
| 0.09, |
| ], |
| "ptx_temp_iptm": [ |
| 0.96, |
| 0.9, |
| 0.87, |
| 0.88, |
| 0.55, |
| 0.58, |
| 0.86, |
| 0.79, |
| 0.69, |
| 0.47, |
| ], |
| "AF2_SR": [47.77, 38.99, 42.11, 15.62, 7.59, 16.52, 12.5, 25.3, 1.34, 5.95], |
| "ptx_sr": [60.3, 25.1, 15.6, 1.3, 2.5, 0.0, 18.9, 14.3, 0.0, 0.0], |
| "ptx_temp_sr": [71.4, 33.9, 20.5, 23.2, 1.5, 0.0, 21.7, 9.5, 4.2, 0.0], |
| "count": "Length 100-120", |
| } |
| elif length < 140 and length >= 120: |
| return { |
| "AF2_ipae": [4.16, 5.51, 5.78, 7.66, 8.48, 9.19, 11.08, 8.12, 22.62, 14.74], |
| "ptx_iptm": [ |
| 0.93, |
| 0.87, |
| 0.83, |
| 0.37, |
| 0.62, |
| 0.51, |
| 0.83, |
| 0.84, |
| 0.27, |
| 0.09, |
| ], |
| "ptx_temp_iptm": [ |
| 0.95, |
| 0.87, |
| 0.87, |
| 0.88, |
| 0.65, |
| 0.59, |
| 0.82, |
| 0.85, |
| 0.74, |
| 0.52, |
| ], |
| "AF2_SR": [48.07, 34.82, 43.45, 12.5, 13.1, 12.8, 8.04, 22.47, 1.19, 4.61], |
| "ptx_sr": [52.2, 22.6, 11.6, 0.6, 1.6, 0.3, 14.4, 15.2, 0.0, 0.0], |
| "ptx_temp_sr": [66.7, 23.2, 21.4, 19.0, 4.2, 0.0, 14.6, 11.9, 4.2, 0.0], |
| "count": "Length 120-140", |
| } |
| else: |
| return { |
| "AF2_ipae": [4.22, 5.56, 5.74, 9.47, 6.74, 9.74, 11.38, 8.37, 23.94, 17.1], |
| "ptx_iptm": [ |
| 0.93, |
| 0.86, |
| 0.8, |
| 0.31, |
| 0.72, |
| 0.52, |
| 0.81, |
| 0.83, |
| 0.23, |
| 0.09, |
| ], |
| "ptx_temp_iptm": [ |
| 0.95, |
| 0.87, |
| 0.89, |
| 0.84, |
| 0.71, |
| 0.56, |
| 0.79, |
| 0.87, |
| 0.72, |
| 0.42, |
| ], |
| "AF2_SR": [45.17, 32.95, 39.2, 10.51, 22.73, 11.36, 7.95, 19.6, 1.7, 4.26], |
| "ptx_sr": [34.7, 18.8, 9.7, 0.6, 3.4, 0.3, 8.2, 22.4, 0.0, 0.0], |
| "ptx_temp_sr": [57.4, 21.0, 23.9, 11.9, 6.2, 0.0, 8.5, 19.9, 4.5, 0.0], |
| "count": "Length 140-150", |
| } |
|
|
|
|
| labels = [ |
| "BHRF1", |
| "PDL1", |
| "IR", |
| "TrkA", |
| "SC2RBD", |
| "VEGF-A", |
| "IL7RA", |
| "H1", |
| "IL17A", |
| "TNFa", |
| ] |
|
|
| difficulty_to_color = { |
| "easy": "#086BFFE8", |
| "hard": "#086BFFE8", |
| "very_hard": "#086BFFE8", |
| } |
| font_path = os.path.join(os.path.dirname(__file__), "Helvetica-Regular.ttf") |
|
|
| text_full = ( |
| "Your submitted case is positioned at the difficulty level shown below, based on evaluations from" |
| + " both AlphaFold2 model (initial guess) and Protenix model. If you believe the target you provided does not" |
| + " match the expected difficulty, you may adjust the input model settings: hotspot location, binder length," |
| + " and target file resolution." |
| ) |
|
|
| text_preview = ( |
| "Your submitted case is positioned at the difficulty level shown below, based on evaluations from" |
| + " AlphaFold2 model (initial guess). If you believe the target you provided does not" |
| + " match the expected difficulty, you may adjust the input model settings: hotspot location, binder length," |
| + " and target file resolution." |
| ) |
|
|
