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  license: apache-2.0
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  tags:
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  - biology
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- - genomics
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  - diffusion
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  - single-cell
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  - transcriptomics
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  # PhenoSeq: Image-Conditioned Diffusion for Single-Cell Transcriptomics
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  [![HuggingFace](https://img.shields.io/badge/🤗%20HuggingFace-Sentinal4D/PhenoSeq-yellow)](https://huggingface.co/Sentinal4D/PhenoSeq)
 
 
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  PhenoSeq is a Gaussian diffusion model that **generates scGPT RNA-seq embeddings conditioned on ViT-L microscopy imaging features**. Given fluorescence microscopy images of a cell or well, it predicts a 512-dimensional scGPT embedding representing the transcriptomic state of individual cells — enabling image-to-transcriptome translation at single-cell resolution.
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  python train.py --config config.yaml
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  ```
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- Key hyperparameters (see [config.yaml](config.yaml)):
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-
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- | Hyperparameter | Value |
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- |---|---|
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- | Batch size | 256 |
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- | Learning rate | 1e-4 (cosine with warmup) |
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- | Epochs | 5,000 (best at epoch 87) |
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- | Model dim | 1,024 |
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- | Attention heads | 8 |
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- | Cross-attention layers | 6 |
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- | Diffusion steps | 1,000 |
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- | Schedule | Cosine |
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- | EMA decay | 0.9999 |
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-
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  ## Data
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  Training and evaluation data come from the [scGeneScope](https://huggingface.co/datasets/altoslabs/scGeneScope) dataset (Altos Labs):
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  ## Citation
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- If you use this model, please cite the scGeneScope dataset:
 
 
 
 
 
 
 
 
 
 
 
 
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  ```bibtex
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  @dataset{scgenescope,
 
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  license: apache-2.0
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  tags:
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  - biology
 
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  - diffusion
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  - single-cell
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  - transcriptomics
 
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  # PhenoSeq: Image-Conditioned Diffusion for Single-Cell Transcriptomics
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  [![HuggingFace](https://img.shields.io/badge/🤗%20HuggingFace-Sentinal4D/PhenoSeq-yellow)](https://huggingface.co/Sentinal4D/PhenoSeq)
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+ [![Paper](https://img.shields.io/badge/Paper-OpenReview-blue)](https://openreview.net/forum?id=ACHMa1e8J1)
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+ [![GitHub](https://img.shields.io/badge/GitHub-reednaidoo/PhenoSeq-black?logo=github)](https://github.com/reednaidoo/PhenoSeq)
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  PhenoSeq is a Gaussian diffusion model that **generates scGPT RNA-seq embeddings conditioned on ViT-L microscopy imaging features**. Given fluorescence microscopy images of a cell or well, it predicts a 512-dimensional scGPT embedding representing the transcriptomic state of individual cells — enabling image-to-transcriptome translation at single-cell resolution.
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  python train.py --config config.yaml
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  ```
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  ## Data
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  Training and evaluation data come from the [scGeneScope](https://huggingface.co/datasets/altoslabs/scGeneScope) dataset (Altos Labs):
 
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  ## Citation
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+ If you use PhenoSeq, please cite our paper:
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+
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+ ```bibtex
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+ @inproceedings{naidoo2026phenoseq,
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+ title = {Cell Painting Generates Single-Cell Transcriptomics via Conditional Diffusion},
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+ author = {Naidoo, Reed and Hu, Jingyu and Tripodi, Giuseppe and Bakal, Chris and Chakraborti, Tapabrata},
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+ booktitle = {ICML 2026 Workshop on Multi-modal Foundation Models and Large Language Models for Life Sciences (FM4LS)},
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+ year = {2026},
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+ url = {https://openreview.net/forum?id=ACHMa1e8J1}
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+ }
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+ ```
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+
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+ Please also cite the training dataset:
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  ```bibtex
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  @dataset{scgenescope,