Instructions to use Tsuboyama-Lab/monoyield-predictor with libraries, inference providers, notebooks, and local apps. Follow these links to get started.
- Libraries
- PEFT
How to use Tsuboyama-Lab/monoyield-predictor with PEFT:
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- Notebooks
- Google Colab
- Kaggle
Add paper title and citation (bioRxiv preprint)
Browse files
README.md
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# monoyield-predictor: trained weights
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LoRA adapters and regression heads that predict the **monomeric expression yield in *E. coli*** (log10 mg/L) of a protein sequence.
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Companion weights of the paper *
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The files contain only the trained LoRA matrices and the regression head (7-12 MB per fold). The frozen base models are downloaded from Hugging Face when the code runs.
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ESMC-6B (MIT with third-party notices and the Biohub Acceptable Use Policy, https://biohub.org/acceptable-use-policy/) and SaProt (MIT).
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## Citation
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# monoyield-predictor: trained weights
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LoRA adapters and regression heads that predict the **monomeric expression yield in *E. coli*** (log10 mg/L) of a protein sequence.
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Companion weights of the paper *Massively parallel quantification and prediction of monomeric protein yield in Escherichia coli* (bioRxiv preprint, https://doi.org/10.64898/2026.11.02.763507) and the code repository **https://github.com/tsubo-lab/monoyield-predictor**.
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The files contain only the trained LoRA matrices and the regression head (7-12 MB per fold). The frozen base models are downloaded from Hugging Face when the code runs.
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ESMC-6B (MIT with third-party notices and the Biohub Acceptable Use Policy, https://biohub.org/acceptable-use-policy/) and SaProt (MIT).
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## Citation
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If you use these weights, please cite the preprint:
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Setsu S, Kiyokawa K, Lam AYW, Mishiro-Sato E, Tomari Y, Tsuboyama K. Massively parallel quantification and prediction of monomeric protein yield in *Escherichia coli*. *bioRxiv* (2026). https://doi.org/10.64898/2026.11.02.763507
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```bibtex
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@article{setsu2026monoyield,
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title = {Massively parallel quantification and prediction of monomeric protein yield in Escherichia coli},
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author = {Setsu, Selena and Kiyokawa, Kaori and Lam, Andy Y. W. and Mishiro-Sato, Emi and Tomari, Yukihide and Tsuboyama, Kotaro},
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journal = {bioRxiv},
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year = {2026},
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doi = {10.64898/2026.11.02.763507}
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}
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```
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