File size: 5,546 Bytes
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"frozen_cache": {
"identity_axis_sha256": "c6765f386d066ec731442316c88395acee2ab6fbef009a5a2fd59696b738b6fd",
"path": "inputs/responses_ab.npy",
"sha256": "bb48bae7f864c66b242a77cef064ff967b418d22bb11416630548f6a6d094a94",
"shape": [
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"gate_decision": "PASS: `view_specific_batch_weighted` reproduces every sampled FIT/SELECT delta element at atol=1e-05, rtol=1e-05. Gate 2 may materialize quarantined endpoint assets using this exact recipe, then must validate the invariant on all identities before release.",
"pairing_statement": "Each endpoint candidate has a deterministic perturbation pseudobulk goal in each A/B batch-disjoint view. The source candidate is a deterministic weighted mixture of batch-specific control pseudobulks; this audit tests whether its weights are pooled across views or restricted to the endpoint view.",
"raw": {
"aggregation": "per-cell library-size 10000 then log1p; mean pseudobulk",
"gene_order_exact_match": true,
"path": "PUBLIC_SOURCE/ReplogleWeissman2022_K562_gwps.h5ad",
"sha256": "d3269d9c863d96555eba768b42ab330cc1b57493cd33b4ac8fe7fbab8278f104",
"shape": [
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},
"sample": {
"count": 64,
"identities": [
"OSBPL8",
"SSX4",
"ZNF576",
"NFE2L1",
"NRIP1",
"SEC16A",
"CSNK1A1",
"CRADD",
"SYVN1",
"SPATA2L",
"DNAJC30",
"UPRT",
"TLE3",
"ARGFX",
"IFT80",
"ZSCAN23",
"MLF2",
"LARP4",
"HIST1H2BL",
"GEMIN7",
"TKT",
"ERVW-1",
"C14orf178",
"ZNF384",
"NOTUM",
"GAA",
"BTBD10",
"COX16",
"MAP1LC3B",
"ATF6",
"PPP2R3B",
"EBAG9",
"SRP72",
"EIF2B5",
"L3HYPDH",
"OTP",
"OTX2",
"ENTR1",
"DCPS",
"TICRR",
"TAX1BP3",
"COCH",
"ZFPL1",
"GNA13",
"ZNF442",
"VENTX",
"ZBTB40",
"STX6",
"SMG6",
"MTMR4",
"RELA",
"BBC3",
"MOK",
"CTPS2",
"PSMC1",
"ZNF48",
"ATP1A1",
"RAP2B",
"DARS",
"PIN4",
"MIF",
"ARL6IP1",
"TASOR2",
"CWC15"
],
"roles": [
"G_fit",
"G_select"
],
"selection": "SHA-256 deterministic identity order with salt SOURCE_GOAL_ASSET_RESOLUTION_V1|20260916"
},
"sampled_cache_recipe_comparison": {
"all_batch_weighted": {
"A": {
"all_close": false,
"fraction_close": 0.002911690712900097,
"max_abs_error": 0.07813365560047059,
"mean_abs_error": 0.0030257416010429335
},
"B": {
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"fraction_close": 0.002907901915615907,
"max_abs_error": 0.09024386034321341,
"mean_abs_error": 0.003004935907370192
}
},
"view_specific_batch_weighted": {
"A": {
"all_close": true,
"fraction_close": 1.0,
"max_abs_error": 1.4648724722121642e-06,
"mean_abs_error": 9.106084045687916e-09
},
"B": {
"all_close": true,
"fraction_close": 1.0,
"max_abs_error": 1.4948276128023963e-06,
"mean_abs_error": 8.249161447296022e-09
}
}
},
"schema": "SOURCE_GOAL_ASSET_RESOLUTION_V1_GATE_1",
"source_diversity": {
"all_batch_weighted_shared_across_views": {
"control_mean_matrix_rank": 267,
"coordinate_variance_mean": 1.4186932821180593e-05,
"distinct_control_mixture_profile_fraction": 1.0,
"distinct_control_mixture_profiles": 9205,
"distinct_source_expression_profile_fraction": 1.0,
"distinct_source_expression_profiles_float32": 9205,
"max_perturbations_per_control_mixture": 1,
"queries": 9205,
"sample_pair_count": 10000,
"sample_pair_max_l2_distance": 1.3801618177203594,
"sample_pair_mean_l2_distance": 0.4570262069036828,
"sample_pair_median_l2_distance": 0.42392650150797745,
"source_profile_identity_proven": true
},
"view_A_batch_weighted": {
"control_mean_matrix_rank": 267,
"coordinate_variance_mean": 2.707875577707947e-05,
"distinct_control_mixture_profile_fraction": 1.0,
"distinct_control_mixture_profiles": 9205,
"distinct_source_expression_profile_fraction": 1.0,
"distinct_source_expression_profiles_float32": 9205,
"max_perturbations_per_control_mixture": 1,
"queries": 9205,
"sample_pair_count": 10000,
"sample_pair_max_l2_distance": 2.3858092804354647,
"sample_pair_mean_l2_distance": 0.6300420630208424,
"sample_pair_median_l2_distance": 0.5824798516784221,
"source_profile_identity_proven": true
},
"view_B_batch_weighted": {
"control_mean_matrix_rank": 267,
"coordinate_variance_mean": 2.9616065717047468e-05,
"distinct_control_mixture_profile_fraction": 1.0,
"distinct_control_mixture_profiles": 9205,
"distinct_source_expression_profile_fraction": 1.0,
"distinct_source_expression_profiles_float32": 9205,
"max_perturbations_per_control_mixture": 1,
"queries": 9205,
"sample_pair_count": 9998,
"sample_pair_max_l2_distance": 2.2753692170298243,
"sample_pair_mean_l2_distance": 0.6546830657966001,
"sample_pair_median_l2_distance": 0.6043989240791572,
"source_profile_identity_proven": true
}
},
"status": "GATE_1_PASS_PAIRING_SEMANTICS_RESOLVED",
"tolerance": {
"atol": 1e-05,
"rtol": 1e-05
}
}
|