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Add the 22 concept probing configs

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  1. LICENSE +2 -0
  2. README.md +269 -0
  3. functional_sites/metadata.json +21 -0
  4. functional_sites/test.parquet +3 -0
  5. functional_sites/train.parquet +3 -0
  6. functional_sites/validation.parquet +3 -0
  7. go_bp/metadata.json +319 -0
  8. go_bp/test.parquet +3 -0
  9. go_bp/train.parquet +3 -0
  10. go_bp/validation.parquet +3 -0
  11. go_cc/metadata.json +179 -0
  12. go_cc/test.parquet +3 -0
  13. go_cc/train.parquet +3 -0
  14. go_cc/validation.parquet +3 -0
  15. go_mf/metadata.json +138 -0
  16. go_mf/test.parquet +3 -0
  17. go_mf/train.parquet +3 -0
  18. go_mf/validation.parquet +3 -0
  19. interpro_active_site/metadata.json +73 -0
  20. interpro_active_site/test.parquet +3 -0
  21. interpro_active_site/train.parquet +3 -0
  22. interpro_active_site/validation.parquet +3 -0
  23. interpro_binding_site/metadata.json +54 -0
  24. interpro_binding_site/test.parquet +3 -0
  25. interpro_binding_site/train.parquet +3 -0
  26. interpro_binding_site/validation.parquet +3 -0
  27. interpro_conserved_site/metadata.json +349 -0
  28. interpro_conserved_site/test.parquet +3 -0
  29. interpro_conserved_site/train.parquet +3 -0
  30. interpro_conserved_site/validation.parquet +3 -0
  31. interpro_domain/metadata.json +379 -0
  32. interpro_domain/test.parquet +3 -0
  33. interpro_domain/train.parquet +3 -0
  34. interpro_domain/validation.parquet +3 -0
  35. interpro_family/metadata.json +254 -0
  36. interpro_family/test.parquet +3 -0
  37. interpro_family/train.parquet +3 -0
  38. interpro_family/validation.parquet +3 -0
  39. interpro_homologous_superfamily/metadata.json +115 -0
  40. interpro_homologous_superfamily/test.parquet +3 -0
  41. interpro_homologous_superfamily/train.parquet +3 -0
  42. interpro_homologous_superfamily/validation.parquet +3 -0
  43. interpro_repeat/metadata.json +80 -0
  44. interpro_repeat/test.parquet +3 -0
  45. interpro_repeat/train.parquet +3 -0
  46. interpro_repeat/validation.parquet +3 -0
  47. lipidation/metadata.json +40 -0
  48. lipidation/test.parquet +3 -0
  49. lipidation/train.parquet +3 -0
  50. lipidation/validation.parquet +3 -0
LICENSE ADDED
@@ -0,0 +1,2 @@
 
 
 
1
+ Human tasks: CC BY 4.0, from Figshare record 10.6084/m9.figshare.31169506 (https://creativecommons.org/licenses/by/4.0/).
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+ Benchmark tasks metal_ion_binding, localization, ssp_q3 and ssp_q8: Apache 2.0, from huggingface.co/biomap-research.
README.md ADDED
@@ -0,0 +1,269 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ ---
2
+ license: other
3
+ license_name: cc-by-4.0-and-apache-2.0
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+ license_link: LICENSE
5
+ pretty_name: Protein concept probing
6
+ task_categories:
7
+ - text-classification
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+ - token-classification
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+ tags:
10
+ - biology
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+ - protein
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+ - probing
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+ - interpretability
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+ configs:
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+ - config_name: functional_sites
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+ data_files:
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+ - split: train
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+ path: functional_sites/train.parquet
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+ - split: validation
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+ path: functional_sites/validation.parquet
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+ - split: test
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+ path: functional_sites/test.parquet
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+ - config_name: go_bp
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+ data_files:
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+ - split: train
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+ path: go_bp/train.parquet
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+ - split: validation
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+ path: go_bp/validation.parquet
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+ - split: test
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+ path: go_bp/test.parquet
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+ - config_name: go_cc
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+ data_files:
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+ - split: train
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+ path: go_cc/train.parquet
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+ - split: validation
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+ path: go_cc/validation.parquet
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+ - split: test
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+ path: go_cc/test.parquet
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+ - config_name: go_mf
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+ data_files:
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+ - split: train
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+ path: go_mf/train.parquet
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+ - split: validation
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+ path: go_mf/validation.parquet
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+ - split: test
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+ path: go_mf/test.parquet
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+ - config_name: interpro_active_site
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+ data_files:
49
+ - split: train
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+ path: interpro_active_site/train.parquet
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+ - split: validation
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+ path: interpro_active_site/validation.parquet
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+ - split: test
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+ path: interpro_active_site/test.parquet
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+ - config_name: interpro_binding_site
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+ data_files:
57
+ - split: train
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+ path: interpro_binding_site/train.parquet
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+ - split: validation
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+ path: interpro_binding_site/validation.parquet
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+ - split: test
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+ path: interpro_binding_site/test.parquet
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+ - config_name: interpro_conserved_site
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+ data_files:
65
+ - split: train
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+ path: interpro_conserved_site/train.parquet
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+ - split: validation
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+ path: interpro_conserved_site/validation.parquet
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+ - split: test
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+ path: interpro_conserved_site/test.parquet
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+ - config_name: interpro_domain
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+ data_files:
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+ - split: train
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+ path: interpro_domain/train.parquet
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+ - split: validation
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+ path: interpro_domain/validation.parquet
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+ - split: test
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+ path: interpro_domain/test.parquet
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+ - config_name: interpro_family
80
+ data_files:
81
+ - split: train
82
+ path: interpro_family/train.parquet
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+ - split: validation
84
+ path: interpro_family/validation.parquet
85
+ - split: test
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+ path: interpro_family/test.parquet
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+ - config_name: interpro_homologous_superfamily
88
+ data_files:
89
+ - split: train
90
+ path: interpro_homologous_superfamily/train.parquet
91
+ - split: validation
92
+ path: interpro_homologous_superfamily/validation.parquet
93
+ - split: test
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+ path: interpro_homologous_superfamily/test.parquet
95
+ - config_name: interpro_repeat
96
+ data_files:
97
+ - split: train
98
+ path: interpro_repeat/train.parquet
99
+ - split: validation
100
+ path: interpro_repeat/validation.parquet
101
+ - split: test
102
+ path: interpro_repeat/test.parquet
103
+ - config_name: lipidation
104
+ data_files:
105
+ - split: train
106
+ path: lipidation/train.parquet
107
+ - split: validation
108
+ path: lipidation/validation.parquet
109
+ - split: test
110
+ path: lipidation/test.parquet
111
+ - config_name: localization
112
+ data_files:
113
+ - split: train
114
+ path: localization/train.parquet
115
+ - split: validation
116
+ path: localization/validation.parquet
117
+ - split: test
118
+ path: localization/test.parquet
119
+ - config_name: metal_ion_binding
120
+ data_files:
121
+ - split: train
122
+ path: metal_ion_binding/train.parquet
123
+ - split: validation
124
+ path: metal_ion_binding/validation.parquet
125
+ - split: test
126
+ path: metal_ion_binding/test.parquet
127
+ - config_name: peptide
128
+ data_files:
129
+ - split: train
130
+ path: peptide/train.parquet
131
+ - split: validation
132
+ path: peptide/validation.parquet
133
+ - split: test
134
+ path: peptide/test.parquet
135
+ - config_name: phosphorylation
136
+ data_files:
137
+ - split: train
138
+ path: phosphorylation/train.parquet
139
+ - split: validation
140
+ path: phosphorylation/validation.parquet
141
+ - split: test
142
+ path: phosphorylation/test.parquet
143
+ - config_name: post_translational_modification
144
+ data_files:
145
+ - split: train
146
+ path: post_translational_modification/train.parquet
147
+ - split: validation
148
+ path: post_translational_modification/validation.parquet
149
+ - split: test
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+ path: post_translational_modification/test.parquet
151
+ - config_name: prot_param
152
+ data_files:
153
+ - split: train
154
+ path: prot_param/train.parquet
155
+ - split: validation
156
+ path: prot_param/validation.parquet
157
+ - split: test
158
+ path: prot_param/test.parquet
159
+ - config_name: secondary_structure
160
+ data_files:
161
+ - split: train
162
+ path: secondary_structure/train.parquet
163
+ - split: validation
164
+ path: secondary_structure/validation.parquet
165
+ - split: test
166
+ path: secondary_structure/test.parquet
167
+ - config_name: ssp_q3
168
+ data_files:
169
+ - split: train
170
+ path: ssp_q3/train.parquet
171
+ - split: validation
172
+ path: ssp_q3/validation.parquet
173
+ - split: test
174
+ path: ssp_q3/test.parquet
175
+ - config_name: ssp_q8
176
+ data_files:
177
+ - split: train
178
+ path: ssp_q8/train.parquet
179
+ - split: validation
180
+ path: ssp_q8/validation.parquet
181
+ - split: test
182
+ path: ssp_q8/test.parquet
183
+ - config_name: topology
184
+ data_files:
185
+ - split: train
186
+ path: topology/train.parquet
187
+ - split: validation
188
+ path: topology/validation.parquet
189
+ - split: test
190
+ path: topology/test.parquet
191
+ ---
192
+
193
+ # Protein concept probing
194
+
195
+ Twenty-two protein annotation tasks for probing what a protein language model's internal states encode, from
196
+ amino-acid composition to Gene Ontology terms. Thirteen tasks label a whole protein and nine label each residue. The
197
+ human tasks are reviewed *Homo sapiens* UniProtKB entries shorter than 1,024 residues; four further tasks are
198
+ xTrimoPGLM benchmark tables.
199
+
200
+ | Config | Level | Task | Proteins | Labels | Train / validation / test |
201
+ |---|---|---|---|---|---|
202
+ | `functional_sites` | residue | multiclass | 6,893 | 6 | 4,778 / 1,106 / 1,009 |
203
+ | `go_bp` | protein | multilabel | 12,255 | 304 | 8,591 / 1,888 / 1,776 |
204
+ | `go_cc` | protein | multilabel | 16,443 | 164 | 11,409 / 2,457 / 2,577 |
205
+ | `go_mf` | protein | multilabel | 11,504 | 123 | 8,010 / 1,786 / 1,708 |
206
+ | `interpro_active_site` | protein | multilabel | 718 | 58 | 482 / 116 / 120 |
207
+ | `interpro_binding_site` | protein | multilabel | 640 | 39 | 446 / 87 / 107 |
208
+ | `interpro_conserved_site` | protein | multilabel | 2,948 | 334 | 2,062 / 450 / 436 |
209
+ | `interpro_domain` | protein | multilabel | 8,003 | 364 | 5,307 / 1,371 / 1,325 |
210
+ | `interpro_family` | protein | multilabel | 3,601 | 239 | 2,097 / 678 / 826 |
211
+ | `interpro_homologous_superfamily` | protein | multilabel | 8,198 | 100 | 5,499 / 1,368 / 1,331 |
212
+ | `interpro_repeat` | protein | multilabel | 1,189 | 65 | 819 / 189 / 181 |
213
+ | `lipidation` | residue | multiclass | 978 | 25 | 654 / 129 / 195 |
214
+ | `localization` | protein | multiclass | 7,530 | 10 | 5,321 / 590 / 1,619 |
215
+ | `metal_ion_binding` | protein | binary | 7,242 | 1 | 5,346 / 599 / 1,297 |
216
+ | `peptide` | residue | multiclass | 4,977 | 4 | 3,485 / 700 / 792 |
217
+ | `phosphorylation` | residue | multiclass | 8,648 | 6 | 6,057 / 1,304 / 1,287 |
218
+ | `post_translational_modification` | residue | multiclass | 15,349 | 12 | 10,722 / 2,400 / 2,227 |
219
+ | `prot_param` | protein | regression | 18,126 | 31 | 12,747 / 2,777 / 2,602 |
220
+ | `secondary_structure` | residue | multiclass | 8,986 | 4 | 6,310 / 1,351 / 1,325 |
221
+ | `ssp_q3` | residue | multiclass | 11,479 | 3 | 9,731 / 1,083 / 665 |
222
+ | `ssp_q8` | residue | multiclass | 11,479 | 8 | 9,731 / 1,083 / 665 |
223
+ | `topology` | residue | multiclass | 4,777 | 17 | 3,378 / 754 / 645 |
224
+
225
+ ## Homology leakage
226
+
227
+ The human tasks keep their published cluster splits: MMseqs2 clusters at 20% identity (30% for InterPro active
228
+ site, binding site, conserved site and repeat) are assigned whole to train plus validation or to test, and
229
+ validation clusters are drawn at 50% identity from the rest, with 80% coverage of the target sequence. The four
230
+ benchmark tasks keep their published test split, and validation is a random 10% of their train split, so they hold
231
+ no homology guarantee between train and validation.
232
+
233
+ ## How it was built
234
+
235
+ 1. Read each curated human table and its recorded train, validation and test assignment.
236
+ 2. Turn its targets into one `label` column: a multi-hot vector over the InterPro entries or Gene Ontology terms,
237
+ 31 ProtParam values, or one class index per residue in the contiguous order of the classes the table holds.
238
+ 3. For Gene Ontology, keep the terms with more than six positive proteins in both validation and test.
239
+ 4. For the four benchmark tables, split 10% of train off as validation with seed 184502, then drop sequences of
240
+ 1,024 residues or more.
241
+
242
+ ## Columns
243
+
244
+ | Column | Meaning |
245
+ |---|---|
246
+ | `id` | UniProt accession for the human tasks; a stable sequence-derived id for the benchmark tasks |
247
+ | `sequence` | amino-acid sequence |
248
+ | `label` | multi-hot list (multilabel), list of 31 floats (regression), integer (binary or multiclass), or one integer per residue (residue tasks) |
249
+
250
+ Each config folder also holds `metadata.json` with the task level, task type and label names. The benchmark tables
251
+ publish their classes but not the order of their integers, so their label names are `class_<n>`.
252
+
253
+ ## What a model trained on it may say
254
+
255
+ These are probing benchmarks. InterPro entries and many UniProt features are curated with computational evidence,
256
+ so a probe here measures agreement with the annotations, not experimentally measured function. Residue tasks count
257
+ unannotated residues as their own class (`-`), which dominates most of them.
258
+
259
+ ## Sources and licence
260
+
261
+ The human tasks are the curated tables of Figshare record 10.6084/m9.figshare.31169506, released under CC BY 4.0,
262
+ built from UniProtKB (accessed 2025-09-09) and the InterPro entry list (accessed 2025-09-16). The four benchmark
263
+ tasks (`metal_ion_binding`, `localization`, `ssp_q3`, `ssp_q8`) are from `biomap-research` on Hugging Face under
264
+ Apache 2.0.
265
+
266
+ ## Files
267
+
268
+ `<config>/train.parquet`, `<config>/validation.parquet`, `<config>/test.parquet` and `<config>/metadata.json` for each
269
+ of the 22 configs.
functional_sites/metadata.json ADDED
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1
+ {
2
+ "config": "functional_sites",
3
+ "task_level": "residue",
4
+ "task_type": "multiclass",
5
+ "num_labels": 6,
6
+ "label_names": [
7
+ "-",
8
+ "ACT_SITE",
9
+ "ACT_SITE,BINDING",
10
+ "BINDING",
11
+ "BINDING,DNA_BIND",
12
+ "DNA_BIND"
13
+ ],
14
+ "rows": {
15
+ "train": 4778,
16
+ "validation": 1106,
17
+ "test": 1009
18
+ },
19
+ "source": "Figshare record 31169506, file h_sapiens_proteome_uniprot_functional_sites_clustersplit_20_50.parquet.gz",
20
+ "licence": "CC BY 4.0"
21
+ }
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1
+ {
2
+ "config": "go_bp",
3
+ "task_level": "protein",
4
+ "task_type": "multilabel",
5
+ "num_labels": 304,
6
+ "label_names": [
7
+ "B cell differentiation [GO:0030183]",
8
+ "B cell proliferation [GO:0042100]",
9
+ "BMP signaling pathway [GO:0030509]",
10
+ "DNA damage response [GO:0006974]",
11
+ "DNA recombination [GO:0006310]",
12
+ "DNA repair [GO:0006281]",
13
+ "DNA replication [GO:0006260]",
14
+ "DNA-templated transcription [GO:0006351]",
15
+ "ERAD pathway [GO:0036503]",
16
+ "G protein-coupled receptor signaling pathway [GO:0007186]",
17
+ "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]",
18
+ "Golgi organization [GO:0007030]",
19
+ "MAPK cascade [GO:0000165]",
20
+ "Notch signaling pathway [GO:0007219]",
21
+ "RNA processing [GO:0006396]",
22
+ "RNA splicing [GO:0008380]",
23
+ "Ras protein signal transduction [GO:0007265]",
24
+ "T cell activation [GO:0042110]",
25
+ "T cell differentiation in thymus [GO:0033077]",
26
+ "T cell receptor signaling pathway [GO:0050852]",
27
+ "Wnt signaling pathway [GO:0016055]",
28
+ "actin cytoskeleton organization [GO:0030036]",
29
+ "actin filament organization [GO:0007015]",
30
+ "adaptive immune response [GO:0002250]",
31
+ "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]",
32
+ "aerobic respiration [GO:0009060]",
33
+ "anatomical structure morphogenesis [GO:0009653]",
34
+ "angiogenesis [GO:0001525]",
35
+ "animal organ morphogenesis [GO:0009887]",
36
+ "anterior/posterior pattern specification [GO:0009952]",
37
+ "antibacterial humoral response [GO:0019731]",
38
+ "antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]",
39
+ "antiviral innate immune response [GO:0140374]",
40
+ "apoptotic process [GO:0006915]",
41
+ "apoptotic signaling pathway [GO:0097190]",
42
+ "autophagosome assembly [GO:0000045]",
43
+ "autophagy [GO:0006914]",
44
+ "axon guidance [GO:0007411]",
45
+ "axonogenesis [GO:0007409]",
46
+ "behavioral fear response [GO:0001662]",
47
+ "blood coagulation [GO:0007596]",
48
+ "bone development [GO:0060348]",
49
+ "brain development [GO:0007420]",
50
+ "calcium ion transport [GO:0006816]",
51
+ "camera-type eye development [GO:0043010]",
52
+ "canonical Wnt signaling pathway [GO:0060070]",
53
+ "carbohydrate metabolic process [GO:0005975]",
54
+ "cell adhesion [GO:0007155]",
55
+ "cell chemotaxis [GO:0060326]",
56
+ "cell differentiation [GO:0030154]",
57
+ "cell division [GO:0051301]",
58
+ "cell migration [GO:0016477]",
59
+ "cell morphogenesis [GO:0000902]",
60
+ "cell population proliferation [GO:0008283]",
61
+ "cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]",
62
+ "cell surface receptor signaling pathway [GO:0007166]",
63
+ "cell-cell adhesion [GO:0098609]",
64
+ "cell-cell signaling [GO:0007267]",
65
+ "cellular response to cAMP [GO:0071320]",
66
+ "cellular response to calcium ion [GO:0071277]",
67
+ "cellular response to glucose stimulus [GO:0071333]",
68
+ "cellular response to hypoxia [GO:0071456]",
69
+ "cellular response to insulin stimulus [GO:0032869]",
70
+ "cellular response to leukemia inhibitory factor [GO:1990830]",
71
+ "cellular response to lipopolysaccharide [GO:0071222]",
72
+ "cellular response to mechanical stimulus [GO:0071260]",
73
+ "cellular response to oxidative stress [GO:0034599]",
74
+ "cellular response to retinoic acid [GO:0071300]",
75
+ "cellular response to tumor necrosis factor [GO:0071356]",
76
+ "cellular response to type II interferon [GO:0071346]",
77
+ "cellular response to virus [GO:0098586]",
78
+ "central nervous system development [GO:0007417]",
79
+ "cerebral cortex development [GO:0021987]",
80
+ "chemical synaptic transmission [GO:0007268]",
81
+ "chemotaxis [GO:0006935]",
82
+ "chloride transmembrane transport [GO:1902476]",
83
+ "cholesterol homeostasis [GO:0042632]",
84
+ "cholesterol metabolic process [GO:0008203]",
85
+ "chromatin organization [GO:0006325]",
86
+ "chromatin remodeling [GO:0006338]",
87
+ "chromosome segregation [GO:0007059]",
88
+ "cilium assembly [GO:0060271]",
89
+ "cytokine-mediated signaling pathway [GO:0019221]",
90
+ "cytoplasmic translation [GO:0002181]",
91
+ "cytoskeleton organization [GO:0007010]",
92
+ "defense response to Gram-negative bacterium [GO:0050829]",
93
+ "defense response to Gram-positive bacterium [GO:0050830]",
94
+ "defense response to bacterium [GO:0042742]",
95
+ "defense response to virus [GO:0051607]",
96
+ "determination of left/right symmetry [GO:0007368]",
97
+ "double-strand break repair [GO:0006302]",
98
+ "double-strand break repair via homologous recombination [GO:0000724]",
99
+ "endocytic recycling [GO:0032456]",
100
+ "endocytosis [GO:0006897]",
101
+ "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]",
102
+ "endoplasmic reticulum unfolded protein response [GO:0030968]",
103
+ "energy homeostasis [GO:0097009]",
104
+ "epithelial cell proliferation [GO:0050673]",
105
+ "establishment of localization in cell [GO:0051649]",
106
+ "exocytosis [GO:0006887]",
107
+ "extracellular matrix organization [GO:0030198]",
108
+ "fat cell differentiation [GO:0045444]",
109
+ "fatty acid biosynthetic process [GO:0006633]",
110
+ "fatty acid metabolic process [GO:0006631]",
111
+ "female pregnancy [GO:0007565]",
112
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113
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114
+ "glucose homeostasis [GO:0042593]",
115
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116
+ "glutathione metabolic process [GO:0006749]",
117
+ "heart development [GO:0007507]",
118
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119
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120
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121
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122
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123
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124
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125
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126
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127
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128
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129
+ "intracellular protein transport [GO:0006886]",
130
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131
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132
+ "killing of cells of another organism [GO:0031640]",
133
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134
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135
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136
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137
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138
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139
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140
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141
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142
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143
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144
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145
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146
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147
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148
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149
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150
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151
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152
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153
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154
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155
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156
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157
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158
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159
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160
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161
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162
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163
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164
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165
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166
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167
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168
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169
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170
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171
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172
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173
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174
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175
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176
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177
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178
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179
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180
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181
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182
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183
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184
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185
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186
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187
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188
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189
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190
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191
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192
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193
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194
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195
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196
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197
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198
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199
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200
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201
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202
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203
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204
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205
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206
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207
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208
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209
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210
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211
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212
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213
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214
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215
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216
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217
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218
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219
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220
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221
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222
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223
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224
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225
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226
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227
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228
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229
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230
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231
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232
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233
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234
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235
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236
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237
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238
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239
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240
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241
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242
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243
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244
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245
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246
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247
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248
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249
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250
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251
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252
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253
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254
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255
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256
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257
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258
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259
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260
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261
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262
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263
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264
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265
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266
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267
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268
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269
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270
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271
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272
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273
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274
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275
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276
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277
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278
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279
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280
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281
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282
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283
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284
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285
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286
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287
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288
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289
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290
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291
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292
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293
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294
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295
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296
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297
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298
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299
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300
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301
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302
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303
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304
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305
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306
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307
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308
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309
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310
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311
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312
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78
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88
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91
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92
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96
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109
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116
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117
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118
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120
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121
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122
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125
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141
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143
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144
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151
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153
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155
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165
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166
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8
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9
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10
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11
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12
+ "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]",
13
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14
+ "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]",
15
+ "DNA-binding transcription factor binding [GO:0140297]",
16
+ "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]",
17
+ "G protein activity [GO:0003925]",
18
+ "G protein-coupled receptor activity [GO:0004930]",
19
+ "G protein-coupled receptor binding [GO:0001664]",
20
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22
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23
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24
+ "NADH dehydrogenase (ubiquinone) activity [GO:0008137]",
25
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26
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27
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28
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31
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32
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33
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34
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35
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36
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37
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39
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40
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41
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43
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44
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45
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46
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47
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48
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51
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52
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53
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54
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55
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56
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57
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58
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59
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60
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61
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62
+ "kinase binding [GO:0019900]",
63
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64
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65
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66
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67
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68
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69
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70
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71
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72
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73
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74
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75
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76
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77
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78
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79
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80
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81
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82
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83
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84
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85
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86
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87
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88
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89
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91
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92
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93
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94
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95
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96
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97
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98
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99
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100
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101
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102
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103
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104
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105
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106
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107
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108
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109
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110
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111
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112
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113
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114
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122
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123
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127
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31
+ "IPR001589__actinin-type_actin-binding_domain,_conserved_site",
32
+ "IPR001751__s100/calcium_binding_protein_7/8-like,_conserved_site",
33
+ "IPR001824__tyrosine-protein_kinase,_receptor_class_iii,_conserved_site",
34
+ "IPR001827__homeobox_protein,_antennapedia_type,_conserved_site",
35
+ "IPR001858__phosphatidylethanolamine-binding,_conserved_site",
36
+ "IPR001999__osteonectin-like,_conserved_site",
37
+ "IPR002011__tyrosine-protein_kinase,_receptor_class_ii,_conserved_site",
38
+ "IPR002012__gonadotropin-releasing_hormone",
39
+ "IPR002052__dna_methylase,_n-6_adenine-specific,_conserved_site",
40
+ "IPR002173__carbohydrate/purine_kinase,_pfkb,_conserved_site",
41
+ "IPR002194__chaperonin_tcp-1,_conserved_site",
42
+ "IPR002328__alcohol_dehydrogenase,_zinc-type,_conserved_site",
43
+ "IPR002364__quinone_oxidoreductase/zeta-crystallin,_conserved_site",
44
+ "IPR002464__dna/rna_helicase,_atp-dependent,_deah-box_type,_conserved_site",
45
+ "IPR003006__immunoglobulin/major_histocompatibility_complex,_conserved_site",
46
+ "IPR003109__goloco_motif",
47
+ "IPR003527__mitogen-activated_protein_(map)_kinase,_conserved_site",
48
+ "IPR003528__long_hematopoietin_receptor,_single_chain,_conserved_site",
49
+ "IPR003529__long_hematopoietin_receptor,_gp130_family_2,_conserved_site",
50
+ "IPR003530__long_hematopoietin_receptor,_soluble_alpha_chain,_conserved_site",
51
+ "IPR003531__short_hematopoietin_receptor,_family_1,_conserved_site",
52
+ "IPR003532__short_hematopoietin_receptor,_family_2,_conserved_site",
53
+ "IPR003651__endonuclease_iii-like,_iron-sulphur_cluster_loop_motif",
54
+ "IPR003903__ubiquitin_interacting_motif",
55
+ "IPR003960__atpase,_aaa-type,_conserved_site",
56
+ "IPR004001__actin,_conserved_site",
57
+ "IPR004036__endonuclease_iii-like,_conserved_site-2",
58
+ "IPR004037__large_ribosomal_subunit_protein_el8-like,_conserved_site",
59
+ "IPR005108__help_motif",
60
+ "IPR005825__large_ribosomal_subunit_protein_ul24,_conserved_site",
61
+ "IPR005829__sugar_transporter,_conserved_site",
62
+ "IPR006012__syntaxin/epimorphin,_conserved_site",
63
+ "IPR006074__gtp1/obg,_conserved_site",
64
+ "IPR006089__acyl-coa_dehydrogenase,_conserved_site",
65
+ "IPR006117__2-5-oligoadenylate_synthetase,_c-terminal_conserved_site",
66
+ "IPR006180__3-hydroxyacyl-coa_dehydrogenase,_conserved_site",
67
+ "IPR006181__d-amino_acid_oxidase,_conserved_site",
68
+ "IPR006203__ghmp_kinase,_atp-binding,_conserved_site",
69
+ "IPR006224__pseudouridine_synthase,_rlua-like,_conserved_site",
70
+ "IPR006594__lis1_homology_motif",
71
+ "IPR007577__glycosyltransferase,_dxd_sugar-binding_motif",
72
+ "IPR007858__dpy-30_motif",
73
+ "IPR008193__dna-directed_rna_polymerase_rpb11,_13-16kda_subunit,_conserved_site",
74
+ "IPR008918__helix-hairpin-helix_motif,_class_2",
75
+ "IPR009818__pam2_motif",
76
+ "IPR013032__egf-like,_conserved_site",
77
+ "IPR013055__tachykinin/neurokinin-like,_conserved_site",
78
+ "IPR013152__gastrin/cholecystokinin,_conserved_site",
79
+ "IPR013992__adenylate_cyclase-associated_cap,_n-terminal",
80
+ "IPR014034__ferritin,_conserved_site",
81
+ "IPR014762__dna_mismatch_repair,_conserved_site",
82
+ "IPR014783__copper_type_ii,_ascorbate-dependent_monooxygenase,_histidine-cluster-2_conserved_site",
83
+ "IPR015875__imp_dehydrogenase_/_gmp_reductase,_conserved_site",
84
+ "IPR015884__malic_enzyme,_conserved_site",
85
+ "IPR015911__phosphoglycerate_kinase,_conserved_site",
86
+ "IPR015912__phosphofructokinase,_conserved_site",
87
+ "IPR016050__proteasome_beta-type_subunit,_conserved_site",
88
+ "IPR016059__dna_ligase,_atp-dependent,_conserved_site",
89
+ "IPR016066__alpha-d-phosphohexomutase,_conserved_site",
90
+ "IPR016157__cullin,_conserved_site",
91
+ "IPR016160__aldehyde_dehydrogenase,_cysteine_active_site",
92
+ "IPR017864__arrestin,_conserved_site",
93
+ "IPR017865__f-actin_capping_protein,_alpha_subunit,_conserved_site",
94
+ "IPR017866__succinyl-coa_synthetase,_beta_subunit,_conserved_site",
95
+ "IPR017870__fes_cluster_insertion,_c-terminal,_conserved_site",
96
+ "IPR017871__abc_transporter-like,_conserved_site",
97
+ "IPR017891__insulin-like_growth_factor_binding_protein,_n-terminal,_cys-rich_conserved_site",
98
+ "IPR017900__4fe-4s_ferredoxin,_iron-sulphur_binding,_conserved_site",
99
+ "IPR017907__zinc_finger,_ring-type,_conserved_site",
100
+ "IPR017937__thioredoxin,_conserved_site",
101
+ "IPR017948__transforming_growth_factor_beta,_conserved_site",
102
+ "IPR017954__lipid-binding_serum_glycoprotein,_conserved_site",
103
+ "IPR017956__at_hook,_dna-binding_motif",
104
+ "IPR017957__p-type_trefoil,_conserved_site",
105
+ "IPR017967__hmg_box_a_dna-binding_domain,_conserved_site",
106
+ "IPR017968__acylphosphatase,_conserved_site",
107
+ "IPR017970__homeobox,_conserved_site",
108
+ "IPR017972__cytochrome_p450,_conserved_site",
109
+ "IPR017974__claudin,_conserved_site",
110
+ "IPR017975__tubulin,_conserved_site",
111
+ "IPR017977__zona_pellucida_domain,_conserved_site",
112
+ "IPR017979__gpcr,_family_3,_conserved_site",
113
+ "IPR017983__gpcr,_family_2,_secretin-like,_conserved_site",
114
+ "IPR017990__connexin,_conserved_site",
115
+ "IPR018000__neurotransmitter-gated_ion-channel,_conserved_site",
116
+ "IPR018016__nucleoside_phosphorylase,_conserved_site",
117
+ "IPR018038__large_ribosomal_subunit_protein_ul30,_conserved_site",
118
+ "IPR018039__intermediate_filament_protein,_conserved_site",
119
+ "IPR018045__sulphate_anion_transporter,_conserved_site",
120
+ "IPR018048__cxc_chemokine,_conserved_site",
121
+ "IPR018049__interleukin-7/interleukin-9,_conserved_site",
122
+ "IPR018054__chromogranin,_conserved_site",
123
+ "IPR018056__kringle,_conserved_site",
124
+ "IPR018066__tubby,_c-terminal,_conserved_site",
125
+ "IPR018067__protein_phosphatase_2a_regulatory_subunit_pr55,_conserved_site",
126
+ "IPR018073__proteinase_inhibitor_i25,_cystatin,_conserved_site",
127
+ "IPR018080__band_7/stomatin-like,_conserved_site",
128
+ "IPR018083__sterol_reductase,_conserved_site",
129
+ "IPR018091__phosphoenolpyruvate_carboxykinase,_gtp-utilising,_conserved_site",
130
+ "IPR018096__interleukin-4/interleukin-13,_conserved_site",
131
+ "IPR018097__egf-like_calcium-binding,_conserved_site",
132
+ "IPR018099__purine_phosphorylase,_family_2,_conserved_site",
133
+ "IPR018102__small_ribosomal_subunit_protein_us11,_conserved_site",
134
+ "IPR018103__translationally_controlled_tumour_protein,_conserved_site",
135
+ "IPR018104__translation_initiation_factor_1a_(eif-1a),_conserved_site",
136
+ "IPR018106__cap,_conserved_site,_n-terminal",
137
+ "IPR018107__sodium:dicarboxylate_symporter,_conserved_site",
138
+ "IPR018116__somatotropin_hormone,_conserved_site",
139
+ "IPR018122__fork_head_domain_conserved_site1",
140
+ "IPR018124__calreticulin/calnexin,_conserved_site",
141
+ "IPR018130__small_ribosomal_subunit_protein_us2,_conserved_site",
142
+ "IPR018134__lysosome-associated_membrane_glycoprotein,_conserved_site",
143
+ "IPR018161__wnt_protein,_conserved_site",
144
+ "IPR018170__aldo/keto_reductase,_conserved_site",
145
+ "IPR018181__heat_shock_protein_70,_conserved_site",
146
+ "IPR018186__transcription_factor,_t-box,_conserved_site",
147
+ "IPR018192__small_ribosomal_subunit_protein_us5,_n-terminal,_conserved_site",
148
+ "IPR018199__small_ribosomal_subunit_protein_es4,_n-terminal,_conserved_site",
149
+ "IPR018200__ubiquitin_specific_protease,_conserved_site",
150
+ "IPR018207__haem_oxygenase_conserved_site",
151
+ "IPR018212__sodium/solute_symporter,_conserved_site",
152
+ "IPR018228__deoxyribonuclease,_tatd-related,_conserved_site",
153
+ "IPR018233__calsequestrin,_conserved_site",
154
+ "IPR018237__myelin_proteolipid_protein_plp,_conserved_site",
155
+ "IPR018240__clathrin_adaptor,_mu_subunit,_conserved_site",
156
+ "IPR018244__allergen_v5/tpx-1-related,_conserved_site",
157
+ "IPR018245__gonadotropin,_beta_subunit,_conserved_site",
158
+ "IPR018252__annexin_repeat,_conserved_site",
159
+ "IPR018253__dnaj_domain,_conserved_site",
160
+ "IPR018255__large_ribosomal_subunit_protein_ul16,_conserved_site,_eukaryotes/archaea",
161
+ "IPR018295__flap/gst2/ltc4s,_conserved_site",
162
+ "IPR018297__adenylyl_cyclase_class-4/guanylyl_cyclase,_conserved_site",
163
+ "IPR018300__aminotransferase,_class_iv,_conserved_site",
164
+ "IPR018314__rsmb/nol1/nop2-like,_conserved_site",
165
+ "IPR018321__glucosamine-6-phosphate_isomerase,_conserved_site",
166
+ "IPR018338__carbonic_anhydrase,_alpha-class,_conserved_site",
167
+ "IPR018350__transcription_factor_coe,_conserved_site",
168
+ "IPR018357__hexapeptide_transferase,_conserved_site",
169
+ "IPR018358__disintegrin,_conserved_site",
170
+ "IPR018359__bromodomain,_conserved_site",
171
+ "IPR018360__calcitonin,_conserved_site",
172
+ "IPR018361__caveolin,_conserved_site",
173
+ "IPR018363__cd59_antigen,_conserved_site",
174
+ "IPR018376__enoyl-coa_hydratase/isomerase,_conserved_site",
175
+ "IPR018378__c-type_lectin,_conserved_site",
176
+ "IPR018446__corticotropin-releasing_factor_conserved_site",
177
+ "IPR018456__ptr2_family_proton/oligopeptide_symporter,_conserved_site",
178
+ "IPR018483__carbohydrate_kinase,_fggy,_conserved_site",
179
+ "IPR018486__hemopexin,_conserved_site",
180
+ "IPR018488__cyclic_nucleotide-binding,_conserved_site",
181
+ "IPR018494__oxysterol-binding_protein,_conserved_site",
182
+ "IPR018498__peripherin/rom-1,_conserved_site",
183
+ "IPR018503__tetraspanin,_conserved_site",
184
+ "IPR018507__cytochrome_c_oxidase,_subunit_via,_conserved_site",
185
+ "IPR018517__trna-dihydrouridine_synthase,_conserved_site",
186
+ "IPR018525__mini-chromosome_maintenance,_conserved_site",
187
+ "IPR018526__glycoside_hydrolase,_family_29,_conserved_site",
188
+ "IPR018935__rio_kinase,_conserved_site",
189
+ "IPR018936__phosphatidylinositol_3-/4-kinase,_conserved_site",
190
+ "IPR018938__glycophorin,_conserved_site",
191
+ "IPR019041__ssxrd_motif",
192
+ "IPR019735__synapsin,_conserved_site",
193
+ "IPR019737__homeobox_engrailed-type,_conserved_site",
194
+ "IPR019739__ctf_transcription_factor/nuclear_factor_1,_conserved_site",
195
+ "IPR019741__galactokinase,_conserved_site",
196
+ "IPR019744__amyloidogenic_glycoprotein,_copper-binding_domain_conserved_site",
197
+ "IPR019745__amyloidogenic_glycoprotein,_intracellular_domain,_conserved_site",
198
+ "IPR019747__ferm_conserved_site",
199
+ "IPR019758__peptidase_s26a,_signal_peptidase_i,_conserved_site",
200
+ "IPR019761__dna-directed_rna_polymerase_m,_15kda_subunit,_conserved_site",
201
+ "IPR019762__dynamin,_gtpase_region,_conserved_site",
202
+ "IPR019763__dynein_light_chain,_type_1/2,_conserved_site",
203
+ "IPR019764__endothelin-like_toxin,_conserved_site",
204
+ "IPR019765__ephrin,_conserved_site",
205
+ "IPR019767__erythropoietin/thrombopoeitin,_conserved_site",
206
+ "IPR019770__eukaryotic_translation_initiation_factor_4e_(eif-4e),_conserved_site",
207
+ "IPR019775__wd40_repeat,_conserved_site",
208
+ "IPR019786__zinc_finger,_phd-type,_conserved_site",
209
+ "IPR019801__glycoside_hydrolase,_family_35,_conserved_site",
210
+ "IPR019803__glypican,_conserved_site",
211
+ "IPR019804__ras_guanine-nucleotide_exchange_factor,_conserved_site",
212
+ "IPR019805__heat_shock_protein_hsp90,_conserved_site",
213
+ "IPR019808__histidine_triad,_conserved_site",
214
+ "IPR019817__interferon_regulatory_factor,_conserved_site",
215
+ "IPR019818__isocitrate/isopropylmalate_dehydrogenase,_conserved_site",
216
+ "IPR019819__carboxylesterase_type_b,_conserved_site",
217
+ "IPR019821__kinesin_motor_domain,_conserved_site",
218
+ "IPR019827__leukemia_inhibitory_factor_/oncostatin,_conserved_site",
219
+ "IPR019828__lysyl_oxidase,_conserved_site",
220
+ "IPR019829__macrophage_migration_inhibitory_factor,_conserved_site",
221
+ "IPR019844__cold-shock_domain,_conserved_site",
222
+ "IPR019846__nerve_growth_factor_conserved_site",
223
+ "IPR019926__large_ribosomal_subunit_protein_ul3,_conserved_site",
224
+ "IPR019954__ubiquitin_conserved_site",
225
+ "IPR019974__xpg_conserved_site",
226
+ "IPR020082__s-adenosyl-l-homocysteine_hydrolase,_conserved_site",
227
+ "IPR020083__large_ribosomal_subunit_protein_el39,_conserved_site",
228
+ "IPR020084__nudix_hydrolase,_conserved_site",
229
+ "IPR020092__pleiotrophin/midkine_heparin-binding_growth_factor,_conserved_site",
230
+ "IPR020392__pancreatic_hormone-like,_conserved_site",
231
+ "IPR020423__interleukin-10,_conserved_site",
232
+ "IPR020550__inositol_monophosphatase,_conserved_site",
233
+ "IPR020556__amidase,_conserved_site",
234
+ "IPR020557__fumarate_lyase,_conserved_site",
235
+ "IPR020574__small_ribosomal_subunit_protein_us9,_conserved_site",
236
+ "IPR020590__guanylate_kinase,_conserved_site",
237
+ "IPR020596__ribosomal_rna_adenine_methylase_transferase,_conserved_site",
238
+ "IPR020611__copper_type_ii,_ascorbate-dependent_monooxygenase,_histidine-cluster-1_conserved_site",
239
+ "IPR020612__methylthiotransferase,_conserved_site",
240
+ "IPR020613__thiolase,_conserved_site",
241
+ "IPR020628__formate-tetrahydrofolate_ligase,_fthfs,_conserved_site",
242
+ "IPR020717__apoptosis_regulator,_bcl-2,_bh1_motif,_conserved_site",
243
+ "IPR020719__rna_3'-terminal_phosphate_cyclase-like,_conserved_site",
244
+ "IPR020726__apoptosis_regulator,_bcl-2,_bh2_motif,_conserved_site",
245
+ "IPR020728__apoptosis_regulator,_bcl-2,_bh3_motif,_conserved_site",
246
+ "IPR020731__apoptosis_regulator,_bcl-2,_bh4_motif,_conserved_site",
247
+ "IPR020809__enolase,_conserved_site",
248
+ "IPR020813__fibrillarin,_conserved_site",
249
+ "IPR020834__lipoxygenase,_conserved_site",
250
+ "IPR020837__fibrinogen,_conserved_site",
251
+ "IPR020845__amp-binding,_conserved_site",
252
+ "IPR020857__serum_albumin,_conserved_site",
253
+ "IPR020863__membrane_attack_complex_component/perforin_domain,_conserved_site",
254
+ "IPR020867__tetrahydrofolate_dehydrogenase/cyclohydrolase,_conserved_site",
255
+ "IPR020877__interleukin-1_conserved_site",
256
+ "IPR020892__cyclophilin-type_peptidyl-prolyl_cis-trans_isomerase,_conserved_site",
257
+ "IPR020894__cadherin_conserved_site",
258
+ "IPR020901__proteinase_inhibitor_i2,_kunitz,_conserved_site",
259
+ "IPR020902__actin/actin-like_conserved_site",
260
+ "IPR020903__epithelial_sodium_channel,_conserved_site",
261
+ "IPR020904__short-chain_dehydrogenase/reductase,_conserved_site",
262
+ "IPR021184__tumour_necrosis_factor,_conserved_site",
263
+ "IPR021939__kank_n-terminal_motif",
264
+ "IPR022272__lipocalin_family_conserved_site",
265
+ "IPR022353__insulin,_conserved_site",
266
+ "IPR022357__major_intrinsic_protein,_conserved_site",
267
+ "IPR022408__acyl-coa-binding_protein,_acbp,_conserved_site",
268
+ "IPR022423__neurohypophysial_hormone,_conserved_site",
269
+ "IPR022631__s-adenosylmethionine_synthetase,_conserved_site",
270
+ "IPR022657__orn/dap/arg_decarboxylase_2,_conserved_site",
271
+ "IPR022678__glycylpeptide_n-tetradecanoyltransferase,_conserved_site",
272
+ "IPR022966__ribonuclease_ii/r,_conserved_site",
273
+ "IPR023152__ras_gtpase-activating_protein,_conserved_site",
274
+ "IPR023174__3'5'-cyclic_nucleotide_phosphodiesterase,_conserved_site",
275
+ "IPR023409__14-3-3_protein,_conserved_site",
276
+ "IPR023415__low-density_lipoprotein_(ldl)_receptor_class_a,_conserved_site",
277
+ "IPR023442__large_ribosomal_subunit_protein_el24,_conserved_site",
278
+ "IPR023563__large_ribosomal_subunit_protein_ul13,_conserved_site",
279
+ "IPR023576__ubie/coq5_methyltransferase,_conserved_site",
280
+ "IPR023581__platelet-derived_growth_factor,_conserved_site",
281
+ "IPR023779__chromo_domain,_conserved_site",
282
+ "IPR023795__serpin,_conserved_site",
283
+ "IPR024607__sulfatase,_conserved_site",
284
+ "IPR025820__methyltransferase_nnmt/pnmt/temt,_conserved_site",
285
+ "IPR027310__profilin_conserved_site",
286
+ "IPR028322__proline-rich_nuclear_receptor_coactivator-like,_proline_rich_region",
287
+ "IPR028417__cap,_conserved_site,_c-terminal",
288
+ "IPR029162__trp-interacting_helix,_inaf_motif",
289
+ "IPR029510__aldehyde_dehydrogenase,_glutamic_acid_active_site",
290
+ "IPR029752__d-isomer_specific_2-hydroxyacid_dehydrogenase,_nad-binding_domain_conserved_site_1",
291
+ "IPR029753__d-isomer_specific_2-hydroxyacid_dehydrogenase,_nad-binding_domain_conserved_site",
292
+ "IPR029760__glutathione_peroxidase_conserved_site",
293
+ "IPR029768__fructose-bisphosphate_aldolase_class-i_active_site",
294
+ "IPR030373__polyamine_biosynthesis_domain,_conserved_site",
295
+ "IPR030456__fork_head_domain_conserved_site_2",
296
+ "IPR030457__elo_family,_conserved_site",
297
+ "IPR030459__glycosyl_hydrolases_family_31,_conserved_site",
298
+ "IPR030470__ubia_prenyltransferase_conserved_site",
299
+ "IPR030473__interleukin-6/gcsf/mgf,_conserved_site",
300
+ "IPR030476__pentaxin,_conserved_site",
301
+ "IPR030479__syndecan,_conserved_site",
302
+ "IPR030480__natriuretic_peptide,_conserved_site",
303
+ "IPR030490__tissue_inhibitor_of_metalloproteinase,_conserved_site",
304
+ "IPR030491__tata-box_binding_protein,_conserved_site",
305
+ "IPR030492__rel_homology_domain,_conserved_site",
306
+ "IPR030514__stathmin,_conserved_site",
307
+ "IPR030659__secy_conserved_site",
308
+ "IPR031157__tr-type_g_domain,_conserved_site",
309
+ "IPR031305__casein_alpha/beta,_conserved_site",
310
+ "IPR031312__sodium/sulphate_symporter,_conserved_site",
311
+ "IPR032458__histone_h2a_conserved_site",
312
+ "IPR033125__deoxyribonuclease_i,_conservied_site",
313
+ "IPR033132__glycosyl_hydrolases_family_1,_n-terminal_conserved_site",
314
+ "IPR033466__cornichon,_conserved_site",
315
+ "IPR033690__adenylate_kinase,_conserved_site",
316
+ "IPR033749__polyprenyl_synthetase,_conserved_site",
317
+ "IPR033773__cbx_family_c-terminal_motif",
318
+ "IPR033774__yaf2/rybp_c-terminal_binding_motif",
319
+ "IPR035090__phosphorylase_pyridoxal-phosphate_attachment_site",
320
+ "IPR035595__udp-glycosyltransferase_family,_conserved_site",
321
+ "IPR043518__2-5-oligoadenylate_synthetase,_n-terminal_conserved_site",
322
+ "IPR043937__golgin_subfamily_a_,_c-terminal_binding_motif",
323
+ "IPR045668__fhf_complex_subunit_hook-interacting_protein,_kelaa_motif",
324
+ "IPR046790__kbtb,_w-type_lir_motif",
325
+ "IPR046793__cysteine_protease_atg4,_f-type_lir_motif",
326
+ "IPR047297__ion-transport_regulator,_fxyd_motif",
327
+ "IPR047862__tsc22/bun,_conserved_site",
328
+ "IPR047864__ribosomal_protein_es26,_conserved_site",
329
+ "IPR048254__cdp-alcohol_phosphatidyltransferase,_conserved_site",
330
+ "IPR048258__cyclins,_cyclin-box",
331
+ "IPR048559__disabled_homolog_1/2,_sulfatide-binding_motif",
332
+ "IPR049704__aminotransferases_class-iii_pyridoxal-phosphate_attachment_site",
333
+ "IPR049947__copper_amine_oxidase,_copper-binding_site",
334
+ "IPR049948__copper_amine_oxidase,_tpq-binding_site",
335
+ "IPR053790__pyrroline-5-carboxylate_reductase-like_conserved_site",
336
+ "IPR053792__atp_p2x_receptor,_conserved_site",
337
+ "IPR053819__tead_interacting_region_3,_omega_loop",
338
+ "IPR055262__gamma-glutamyltranspeptidase,_conserved_site",
339
+ "IPR055333__histone_h2b,_conserved_site",
340
+ "IPR057254__ubiquitin_carboxyl-terminal_hydrolase_family_1,_cysteine_active-site"
341
+ ],
342
+ "rows": {
343
+ "train": 2062,
344
+ "validation": 450,
345
+ "test": 436
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+ },
347
+ "source": "Figshare record 31169506, file h_sapiens_proteome_interpro_InterPro_conserved_site_clustersplit_30_50.parquet.gz",
348
+ "licence": "CC BY 4.0"
349
+ }
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1
+ {
2
+ "config": "interpro_domain",
3
+ "task_level": "protein",
4
+ "task_type": "multilabel",
5
+ "num_labels": 364,
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+ "label_names": [
7
+ "IPR000008__c2_domain",
8
+ "IPR000014__pas_domain",
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+ "IPR000072__pdgf/vegf_domain",
10
+ "IPR000073__alpha/beta_hydrolase_fold-1",
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+ "IPR000086__nudix_hydrolase_domain",
12
+ "IPR000095__crib_domain",
13
+ "IPR000157__toll/interleukin-1_receptor_homology_(tir)_domain",
14
+ "IPR000159__ras-associating_domain",
15
+ "IPR000182__gnat_domain",
16
+ "IPR000195__rab-gap-tbc_domain",
17
+ "IPR000210__btb/poz_domain",
18
+ "IPR000219__dbl_homology_domain",
19
+ "IPR000232__heat_shock_factor_(hsf)-type,_dna-binding",
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+ "IPR000242__tyrosine-specific_protein_phosphatase,_ptpase_domain",
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+ "IPR000253__forkhead-associated_(fha)_domain",
22
+ "IPR000294__gamma-carboxyglutamic_acid-rich_(gla)_domain",
23
+ "IPR000299__ferm_domain",
24
+ "IPR000306__fyve_zinc_finger",
25
+ "IPR000315__b-box-type_zinc_finger",
26
+ "IPR000326__phosphatidic_acid_phosphatase_type_2/haloperoxidase",
27
+ "IPR000330__snf2,_n-terminal",
28
+ "IPR000340__dual_specificity_phosphatase,_catalytic_domain",
29
+ "IPR000372__leucine-rich_repeat_n-terminal_domain",
30
+ "IPR000387__tyrosine-specific_protein_phosphatases_domain",
31
+ "IPR000418__ets_domain",
32
+ "IPR000433__zinc_finger,_zz-type",
33
+ "IPR000436__sushi/scr/ccp_domain",
34
+ "IPR000467__g-patch_domain",
35
+ "IPR000483__cysteine-rich_flanking_region,_c-terminal",
36
+ "IPR000488__death_domain",
37
+ "IPR000504__rna_recognition_motif_domain",
38
+ "IPR000532__glucagon/gip/secretin/vip",
39
+ "IPR000535__major_sperm_protein_(msp)_domain",
40
+ "IPR000536__nuclear_hormone_receptor,_ligand-binding_domain",
41
+ "IPR000555__jab1/mpn/mov34_metalloenzyme_domain",
42
+ "IPR000566__lipocalin/cytosolic_fatty-acid_binding_domain",
43
+ "IPR000569__hect_domain",
44
+ "IPR000571__zinc_finger,_ccch-type",
45
+ "IPR000582__acyl-coa-binding_protein,_acbp",
46
+ "IPR000585__hemopexin-like_domain",
47
+ "IPR000608__ubiquitin-conjugating_(ubc),_catalytic_core_domain",
48
+ "IPR000626__ubiquitin-like_domain",
49
+ "IPR000644__cbs_domain",
50
+ "IPR000651__ras-like_guanine_nucleotide_exchange_factor,_n-terminal",
51
+ "IPR000690__matrin/u1-c,_c2h2-type_zinc_finger",
52
+ "IPR000717__proteasome_component_(pci)_domain",
53
+ "IPR000719__protein_kinase_domain",
54
+ "IPR000727__target_snare_coiled-coil_homology_domain",
55
+ "IPR000742__egf-like_domain",
56
+ "IPR000772__ricin_b,_lectin_domain",
57
+ "IPR000859__cub_domain",
58
+ "IPR000863__sulfotransferase_domain",
59
+ "IPR000873__amp-dependent_synthetase/ligase_domain",
60
+ "IPR000909__phosphatidylinositol-specific_phospholipase_c,_x_domain",
61
+ "IPR000953__chromo/chromo_shadow_domain",
62
+ "IPR000961__agc-kinase,_c-terminal",
63
+ "IPR000980__sh2_domain",
64
+ "IPR001005__sant/myb_domain",
65
+ "IPR001039__mhc_class_i_alpha_chain,_alpha1_alpha2_domains",
66
+ "IPR001064__beta/gamma_crystallin",
67
+ "IPR001107__band_7_domain",
68
+ "IPR001111__tgf-beta,_propeptide",
69
+ "IPR001124__lipid-binding_serum_glycoprotein,_c-terminal",
70
+ "IPR001148__alpha_carbonic_anhydrase_domain",
71
+ "IPR001163__sm_domain,_eukaryotic/archaea-type",
72
+ "IPR001164__arf_gtpase_activating_protein",
73
+ "IPR001173__glycosyltransferase_2-like",
74
+ "IPR001202__ww_domain",
75
+ "IPR001206__diacylglycerol_kinase,_catalytic_domain",
76
+ "IPR001212__somatomedin_b_domain",
77
+ "IPR001214__set_domain",
78
+ "IPR001245__serine-threonine/tyrosine-protein_kinase,_catalytic_domain",
79
+ "IPR001247__exoribonuclease,_phosphorolytic_domain_1",
80
+ "IPR001251__cral-trio_lipid_binding_domain",
81
+ "IPR001279__metallo-beta-lactamase",
82
+ "IPR001293__zinc_finger,_traf-type",
83
+ "IPR001296__glycosyl_transferase,_family_1",
84
+ "IPR001304__c-type_lectin-like",
85
+ "IPR001309__peptidase_c14,_p20_domain",
86
+ "IPR001315__card_domain",
87
+ "IPR001356__homeodomain",
88
+ "IPR001357__brct_domain",
89
+ "IPR001365__adenosine_deaminase_domain",
90
+ "IPR001368__tnfr/ngfr_cysteine-rich_region",
91
+ "IPR001394__peptidase_c19,_ubiquitin_carboxyl-terminal_hydrolase",
92
+ "IPR001452__sh3_domain",
93
+ "IPR001478__pdz_domain",
94
+ "IPR001494__importin-beta,_n-terminal_domain",
95
+ "IPR001507__zona_pellucida_domain",
96
+ "IPR001565__synaptotagmin",
97
+ "IPR001594__palmitoyltransferase,_dhhc_domain",
98
+ "IPR001607__zinc_finger,_ubp-type",
99
+ "IPR001623__dnaj_domain",
100
+ "IPR001628__zinc_finger,_nuclear_hormone_receptor-type",
101
+ "IPR001650__helicase,_c-terminal_domain-like",
102
+ "IPR001660__sterile_alpha_motif_domain",
103
+ "IPR001683__phox_homology",
104
+ "IPR001715__calponin_homology_domain",
105
+ "IPR001739__methyl-cpg_dna_binding",
106
+ "IPR001752__kinesin_motor_domain",
107
+ "IPR001763__rhodanese-like_domain",
108
+ "IPR001766__fork_head_domain",
109
+ "IPR001781__zinc_finger,_lim-type",
110
+ "IPR001810__f-box_domain",
111
+ "IPR001811__chemokine_interleukin-8-like_domain",
112
+ "IPR001818__peptidase_m10,_metallopeptidase",
113
+ "IPR001839__transforming_growth_factor-beta,_c-terminal",
114
+ "IPR001841__zinc_finger,_ring-type",
115
+ "IPR001849__pleckstrin_homology_domain",
116
+ "IPR001870__b30.2/spry_domain",
117
+ "IPR001878__zinc_finger,_cchc-type",
118
+ "IPR001881__egf-like_calcium-binding_domain",
119
+ "IPR001895__ras_guanine-nucleotide_exchange_factors_catalytic_domain",
120
+ "IPR001909__krueppel-associated_box",
121
+ "IPR001932__ppm-type_phosphatase-like_domain",
122
+ "IPR001965__zinc_finger,_phd-type",
123
+ "IPR002014__vhs_domain",
124
+ "IPR002018__carboxylesterase,_type_b",
125
+ "IPR002035__von_willebrand_factor,_type_a",
126
+ "IPR002048__ef-hand_domain",
127
+ "IPR002058__pap/25a-associated",
128
+ "IPR002068__alpha_crystallin/hsp20_domain",
129
+ "IPR002073__3'5'-cyclic_nucleotide_phosphodiesterase,_catalytic_domain",
130
+ "IPR002123__phospholipid/glycerol_acyltransferase",
131
+ "IPR002125__cytidine_and_deoxycytidylate_deaminase_domain",
132
+ "IPR002126__cadherin-like",
133
+ "IPR002138__peptidase_c14,_caspase_non-catalytic_subunit_p10",
134
+ "IPR002219__protein_kinase_c-like,_phorbol_ester/diacylglycerol-binding_domain",
135
+ "IPR002314__aminoacyl-trna_synthetase,_class_ii_(g/_p/_s/t)",
136
+ "IPR002350__kazal_domain",
137
+ "IPR002498__phosphatidylinositol-4-phosphate_4/5-kinase,_core",
138
+ "IPR002562__3'-5'_exonuclease_domain",
139
+ "IPR002589__macro_domain",
140
+ "IPR002645__stas_domain",
141
+ "IPR002867__ibr_domain",
142
+ "IPR002893__zinc_finger,_mynd-type",
143
+ "IPR002913__start_domain",
144
+ "IPR002931__transglutaminase-like",
145
+ "IPR003029__s1_domain",
146
+ "IPR003103__bag_domain",
147
+ "IPR003112__olfactomedin-like_domain",
148
+ "IPR003124__wh2_domain",
149
+ "IPR003137__pa_domain",
150
+ "IPR003172__md-2-related_lipid-recognition_domain",
151
+ "IPR003309__scan_domain",
152
+ "IPR003316__e2f/dp_family,_winged-helix_dna-binding_domain",
153
+ "IPR003323__otu_domain",
154
+ "IPR003347__jmjc_domain",
155
+ "IPR003439__abc_transporter-like,_atp-binding_domain",
156
+ "IPR003533__doublecortin_domain",
157
+ "IPR003593__aaa+_atpase_domain",
158
+ "IPR003595__protein-tyrosine_phosphatase,_catalytic",
159
+ "IPR003597__immunoglobulin_c1-set",
160
+ "IPR003598__immunoglobulin_subtype_2",
161
+ "IPR003599__immunoglobulin_domain_subtype",
162
+ "IPR003604__matrin/u1-c-like,_c2h2-type_zinc_finger",
163
+ "IPR003607__hd/pdease_domain",
164
+ "IPR003617__transcription_elongation_factor,_tfiis/crsp70,_n-terminal,_sub-type",
165
+ "IPR003618__transcription_elongation_factor_s-ii,_central_domain",
166
+ "IPR003645__follistatin-like,_n-terminal",
167
+ "IPR003649__b-box,_c-terminal",
168
+ "IPR003650__orange_domain",
169
+ "IPR003654__oar_domain",
170
+ "IPR003877__spry_domain",
171
+ "IPR003879__butyrophylin-like,_spry_domain",
172
+ "IPR003887__lem_domain",
173
+ "IPR003890__mif4g-like,_type_3",
174
+ "IPR003891__initiation_factor_eif-4_gamma,_ma3",
175
+ "IPR003892__ubiquitin_system_component_cue",
176
+ "IPR003954__rna_recognition_motif_domain,_eukaryotic-type",
177
+ "IPR003958__transcription_factor_cbf/nf-y/archaeal_histone_domain",
178
+ "IPR003959__atpase,_aaa-type,_core",
179
+ "IPR003961__fibronectin_type_iii",
180
+ "IPR004012__run_domain",
181
+ "IPR004043__lccl_domain",
182
+ "IPR004045__glutathione_s-transferase,_n-terminal",
183
+ "IPR004046__glutathione_s-transferase,_c-terminal",
184
+ "IPR004087__k_homology_domain",
185
+ "IPR004088__k_homology_domain,_type_1",
186
+ "IPR004113__fad-binding_oxidoreductase/transferase,_type_4,_c-terminal",
187
+ "IPR004182__gram_domain",
188
+ "IPR004217__tim10-like",
189
+ "IPR004364__aminoacyl-trna_synthetase,_class_ii_(d/k/n)",
190
+ "IPR004365__ob-fold_nucleic_acid_binding_domain,_aa-trna_synthetase-type",
191
+ "IPR004367__cyclin,_c-terminal_domain",
192
+ "IPR004826__basic_leucine_zipper_domain,_maf-type",
193
+ "IPR004827__basic-leucine_zipper_domain",
194
+ "IPR004853__sugar_phosphate_transporter_domain",
195
+ "IPR005036__cbm21_(carbohydrate_binding_type-21)_domain",
196
+ "IPR005123__oxoglutarate/iron-dependent_dioxygenase_domain",
197
+ "IPR005135__endonuclease/exonuclease/phosphatase",
198
+ "IPR005225__small_gtp-binding_domain",
199
+ "IPR005576__rna_polymerase_rpb7-like_,_n-terminal",
200
+ "IPR005821__ion_transport_domain",
201
+ "IPR006011__syntaxin,_n-terminal_domain",
202
+ "IPR006020__ptb/pi_domain",
203
+ "IPR006026__peptidase,_metallopeptidase",
204
+ "IPR006052__tumour_necrosis_factor_domain",
205
+ "IPR006073__gtp_binding_domain",
206
+ "IPR006094__fad_linked_oxidase,_n-terminal",
207
+ "IPR006195__aminoacyl-trna_synthetase,_class_ii",
208
+ "IPR006208__glycoprotein_hormone_subunit_beta",
209
+ "IPR006574__spry-associated",
210
+ "IPR006575__rwd_domain",
211
+ "IPR006620__prolyl_4-hydroxylase,_alpha_subunit",
212
+ "IPR006634__tram/lag1/cln8_homology_domain",
213
+ "IPR006640__sprt-like",
214
+ "IPR006642__rad18,_zinc_finger_ubz4-type",
215
+ "IPR006671__cyclin,_n-terminal",
216
+ "IPR006680__amidohydrolase-related",
217
+ "IPR006694__fatty_acid_hydroxylase",
218
+ "IPR006861__hyaluronan/mrna-binding_protein",
219
+ "IPR006909__rad21/rec8-like_protein,_c-terminal,_eukaryotic",
220
+ "IPR006910__rad21/rec8-like_protein,_n-terminal",
221
+ "IPR007052__cs_domain",
222
+ "IPR007110__immunoglobulin-like_domain",
223
+ "IPR007330__mit_domain",
224
+ "IPR007527__zinc_finger,_swim-type",
225
+ "IPR007529__zinc_finger,_hit-type",
226
+ "IPR008174__galanin",
227
+ "IPR008197__wap-type_'four-disulfide_core'_domain",
228
+ "IPR008422__kn_homeodomain",
229
+ "IPR010513__ken_domain",
230
+ "IPR010569__myotubularin-like,_phosphatase_domain",
231
+ "IPR010909__plac",
232
+ "IPR010987__glutathione_s-transferase,_c-terminal-like",
233
+ "IPR011016__zinc_finger,_ring-ch-type",
234
+ "IPR011072__hr1_rho-binding_domain",
235
+ "IPR011124__zinc_finger,_cw-type",
236
+ "IPR011161__mhc_class_i-like_antigen_recognition-like",
237
+ "IPR011545__dead/deah-box_helicase_domain",
238
+ "IPR011547__slc26a/sulp_transporter_domain",
239
+ "IPR011598__myc-type,_basic_helix-loop-helix_(bhlh)_domain",
240
+ "IPR011600__peptidase_c14,_caspase_domain",
241
+ "IPR011611__carbohydrate_kinase_pfkb",
242
+ "IPR011650__peptidase_m20,_dimerisation_domain",
243
+ "IPR012319__formamidopyrimidine-dna_glycosylase,_catalytic_domain",
244
+ "IPR013087__zinc_finger_c2h2-type",
245
+ "IPR013098__immunoglobulin_i-set",
246
+ "IPR013099__potassium_channel_domain",
247
+ "IPR013106__immunoglobulin_v-set_domain",
248
+ "IPR013137__zinc_finger,_tfiib-type",
249
+ "IPR013151__immunoglobulin-like_beta-sandwich_domain",
250
+ "IPR013162__cd80-like,_immunoglobulin_c2-set",
251
+ "IPR013164__cadherin,_n-terminal",
252
+ "IPR013216__methyltransferase_type_11",
253
+ "IPR013520__ribonuclease_h-like_domain",
254
+ "IPR013568__sefir_domain",
255
+ "IPR013655__pas_fold-3",
256
+ "IPR013763__cyclin-like_domain",
257
+ "IPR013766__thioredoxin_domain",
258
+ "IPR013767__pas_fold",
259
+ "IPR014001__helicase_superfamily_1/2,_atp-binding_domain",
260
+ "IPR014014__rna_helicase,_dead-box_type,_q_motif",
261
+ "IPR014020__tensin_phosphatase,_c2_domain",
262
+ "IPR014044__cap_domain",
263
+ "IPR014720__double-stranded_rna-binding_domain",
264
+ "IPR015338__glycosyl_transferase_64_domain",
265
+ "IPR015369__follistatin/osteonectin_egf_domain",
266
+ "IPR015590__aldehyde_dehydrogenase_domain",
267
+ "IPR015847__exoribonuclease,_phosphorolytic_domain_2",
268
+ "IPR015886__formamidopyrimidine-dna_glycosylase,_h2th_dna-binding",
269
+ "IPR015898__g-protein,_gamma_subunit-like_domain",
270
+ "IPR015917__peptidase_c14a,_caspase_catalytic_domain",
271
+ "IPR015940__ubiquitin-associated_domain",
272
+ "IPR016040__nad(p)-binding_domain",
273
+ "IPR016054__ly-6_antigen/upa_receptor-like",
274
+ "IPR016137__rgs_domain",
275
+ "IPR016166__fad-binding_domain,_pcmh-type",
276
+ "IPR016179__insulin-like",
277
+ "IPR016201__psi_domain",
278
+ "IPR017452__gpcr,_rhodopsin-like,_7tm",
279
+ "IPR017455__zinc_finger,_fyve-related",
280
+ "IPR017884__sant_domain",
281
+ "IPR017892__protein_kinase,_c-terminal",
282
+ "IPR017896__4fe-4s_ferredoxin-type,_iron-sulphur_binding_domain",
283
+ "IPR017920__comm_domain",
284
+ "IPR017923__transcription_factor_iis,_n-terminal",
285
+ "IPR017942__lipid-binding_serum_glycoprotein,_n-terminal",
286
+ "IPR017981__gpcr,_family_2-like,_7tm",
287
+ "IPR018484__carbohydrate_kinase_fggy,_n-terminal",
288
+ "IPR018957__zinc_finger,_c3hc4_ring-type",
289
+ "IPR018979__ferm,_n-terminal",
290
+ "IPR018980__ferm,_c-terminal_ph-like_domain",
291
+ "IPR019339__cbf1-interacting_co-repressor_cir,_n-terminal_domain",
292
+ "IPR019383__golgin_subfamily_a_member_7/erf4",
293
+ "IPR019748__ferm_central_domain",
294
+ "IPR019749__band_4.1_domain",
295
+ "IPR019787__zinc_finger,_phd-finger",
296
+ "IPR020067__frizzled_domain",
297
+ "IPR020422__dual_specificity_protein_phosphatase_domain",
298
+ "IPR020479__homeodomain,_metazoa",
299
+ "IPR020635__tyrosine-protein_kinase,_catalytic_domain",
300
+ "IPR020846__major_facilitator_superfamily_domain",
301
+ "IPR022049__fam69,_protein-kinase_domain",
302
+ "IPR022666__large_ribosomal_subunit_protein_ul2,_rna-binding_domain",
303
+ "IPR022669__large_ribosomal_subunit_protein_ul2,_c-terminal",
304
+ "IPR022764__peptidase_s54,_rhomboid_domain",
305
+ "IPR022775__ap_complex,_mu/sigma_subunit",
306
+ "IPR023340__uma_domain",
307
+ "IPR023412__ribonuclease_a-domain",
308
+ "IPR023780__chromo_domain",
309
+ "IPR023796__serpin_domain",
310
+ "IPR023801__histone_deacetylase_domain",
311
+ "IPR024771__suz_domain",
312
+ "IPR025110__amp-binding_enzyme,_c-terminal_domain",
313
+ "IPR025256__tm7s3/tm198-like_domain",
314
+ "IPR025933__beta-defensin_domain",
315
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+ "IPR027450__alpha-ketoglutarate-dependent_dioxygenase_alkb-like",
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+ "IPR045135__26s_proteasome_regulatory_subunit_rpn7,_n-terminal",
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+ "IPR045885__n-acetylgalactosaminyltransferase",
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+ "IPR046371__bcl-2,_bcl-2_homology_region_1-3",
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+ "IPR056436__zic1-5/gli1-3like,_c2h2_zinc_finger",
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+ ],
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+ "test": 1325
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+ "licence": "CC BY 4.0"
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+ "IPR000920__myelin_p0_protein-related",
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+ "IPR001675__glycosyl_transferase_family_29",
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+ "IPR001753__enoyl-coa_hydratase/isomerase",
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+ "IPR002051__haem_oxygenase",
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+ "IPR002067__mitochondrial_carrier_protein",
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+ "IPR002164__nucleosome_assembly_protein_(nap)",
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+ "IPR002209__fibroblast_growth_factor_family",
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+ "IPR002345__lipocalin",
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+ "IPR002347__short-chain_dehydrogenase/reductase_sdr",
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+ "IPR002398__peptidase_c14_family",
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+ "IPR002401__cytochrome_p450,_e-class,_group_i",
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+ "IPR002423__chaperonin_cpn60/groel/tcp-1_family",
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+ "IPR002450__von_ebner's_gland_protein/_bos/can_allergen",
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+ "IPR002494__keratin-associated_protein",
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+ "IPR002495__glycosyl_transferase,_family_8",
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+ "IPR002659__glycosyl_transferase,_family_31",
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+ "IPR002777__prefoldin_beta-like",
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+ "IPR003689__zinc/iron_permease",
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+ "IPR004299__membrane_bound_o-acyl_transferase,_mboat",
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