Add the FineDNA dataset card with mid, SFT and RL configs
Browse files
README.md
ADDED
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| 1 |
+
---
|
| 2 |
+
license: other
|
| 3 |
+
language:
|
| 4 |
+
- en
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| 5 |
+
task_categories:
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| 6 |
+
- text-generation
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| 7 |
+
tags:
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| 8 |
+
- biology
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| 9 |
+
- genomics
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| 10 |
+
- dna
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| 11 |
+
- midtraining
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| 12 |
+
- sft
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| 13 |
+
- rl
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| 14 |
+
pretty_name: FineDNA
|
| 15 |
+
configs:
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| 16 |
+
- config_name: mid_dna_eukaryote_fungi
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| 17 |
+
data_files:
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| 18 |
+
- split: train
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| 19 |
+
path: mid/dna_eukaryote_fungi/train-*.parquet
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| 20 |
+
- config_name: mid_dna_eukaryote_protozoa
|
| 21 |
+
data_files:
|
| 22 |
+
- split: train
|
| 23 |
+
path: mid/dna_eukaryote_protozoa/train-*.parquet
|
| 24 |
+
- config_name: mid_dna_eukaryote_plant
|
| 25 |
+
data_files:
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| 26 |
+
- split: train
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| 27 |
+
path: mid/dna_eukaryote_plant/train-*.parquet
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| 28 |
+
- config_name: mid_dna_eukaryote_invertebrate
|
| 29 |
+
data_files:
|
| 30 |
+
- split: train
|
| 31 |
+
path: mid/dna_eukaryote_invertebrate/train-*.parquet
|
| 32 |
+
- config_name: mid_dna_eukaryote_vertebrate_mammalian
|
| 33 |
+
data_files:
|
| 34 |
+
- split: train
|
| 35 |
+
path: mid/dna_eukaryote_vertebrate_mammalian/train-*.parquet
|
| 36 |
+
- config_name: mid_dna_eukaryote_vertebrate_other
|
| 37 |
+
data_files:
|
| 38 |
+
- split: train
|
| 39 |
+
path: mid/dna_eukaryote_vertebrate_other/train-*.parquet
|
| 40 |
+
- config_name: mid_dna_mrna
|
| 41 |
+
data_files:
|
| 42 |
+
- split: train
|
| 43 |
+
path: mid/dna_mrna/train-*.parquet
|
| 44 |
+
- config_name: mid_dna_mrna_splice
|
| 45 |
+
data_files:
|
| 46 |
+
- split: train
|
| 47 |
+
path: mid/dna_mrna_splice/train-*.parquet
|
| 48 |
+
- config_name: mid_dna_prokaryote
|
| 49 |
+
data_files:
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| 50 |
+
- split: train
|
| 51 |
+
path: mid/dna_prokaryote/train-*.parquet
|
| 52 |
+
- config_name: mid_bio_p90_biorxiv
|
| 53 |
+
data_files:
|
| 54 |
+
- split: train
|
| 55 |
+
path: mid/bio_p90_biorxiv/train-*.parquet
|
| 56 |
+
- split: validation
|
| 57 |
+
path: mid/bio_p90_biorxiv/validation-*.parquet
|
| 58 |
+
- config_name: mid_bio_p90_biostars
|
| 59 |
+
data_files:
|
| 60 |
+
- split: train
|
| 61 |
+
path: mid/bio_p90_biostars/train-*.parquet
|
| 62 |
+
- split: validation
|
| 63 |
+
path: mid/bio_p90_biostars/validation-*.parquet
|
| 64 |
+
- config_name: mid_bio_p90_finepdfs
|
| 65 |
+
data_files:
|
| 66 |
+
- split: train
|
| 67 |
+
path: mid/bio_p90_finepdfs/train-*.parquet
|
| 68 |
+
- split: validation
|
| 69 |
+
path: mid/bio_p90_finepdfs/validation-*.parquet
|
| 70 |
+
- config_name: mid_bio_p90_fineweb
|
| 71 |
+
data_files:
|
| 72 |
+
- split: train
|
| 73 |
+
path: mid/bio_p90_fineweb/train-*.parquet
|
| 74 |
+
- split: validation
|
| 75 |
+
path: mid/bio_p90_fineweb/validation-*.parquet
|
| 76 |
+
- config_name: mid_bio_p90_pubmed
|
| 77 |
+
data_files:
|
| 78 |
+
- split: train
|
| 79 |
+
path: mid/bio_p90_pubmed/train-*.parquet
|
| 80 |
+
- split: validation
|
| 81 |
+
path: mid/bio_p90_pubmed/validation-*.parquet
|
| 82 |
+
- config_name: mid_bio_rest
|
| 83 |
+
data_files:
|
| 84 |
+
- split: train
|
| 85 |
+
path: mid/bio_rest/train-*.parquet
|
| 86 |
+
- split: validation
|
| 87 |
+
path: mid/bio_rest/validation-*.parquet
|
| 88 |
+
- config_name: mid_bio_gemini_fim
|
| 89 |
+
data_files:
|
| 90 |
+
- split: train
|
| 91 |
+
path: mid/bio_gemini_fim/train-*.parquet
|
| 92 |
+
- config_name: mid_bio_gemini_nonfim
|
| 93 |
+
data_files:
|
| 94 |
+
- split: train
|
| 95 |
+
path: mid/bio_gemini_nonfim/train-*.parquet
|
| 96 |
+
- split: validation
|
| 97 |
+
path: mid/bio_gemini_nonfim/validation-*.parquet
|
| 98 |
+
- config_name: mid_english_fineweb_edu
|
| 99 |
+
data_files:
|
| 100 |
+
- split: train
|
| 101 |
+
path: mid/english_fineweb_edu/train-*.parquet
|
| 102 |
+
- config_name: mid_english_dclm
|
| 103 |
+
data_files:
|
| 104 |
+
- split: train
|
| 105 |
+
path: mid/english_dclm/train-*.parquet
|
| 106 |
+
- config_name: mid_english_finepdfs_edu
|
| 107 |
+
data_files:
|
| 108 |
+
- split: train
|
| 109 |
+
path: mid/english_finepdfs_edu/train-*.parquet
|
| 110 |
+
- config_name: mid_instruct_nemotron_chat_v3
|
| 111 |
+
data_files:
|
| 112 |
+
- split: train
|
| 113 |
+
path: mid/instruct_nemotron_chat_v3/train-*.parquet
|
| 114 |
+
- config_name: mid_instruct_nemotron_if_v3
|
| 115 |
+
data_files:
|
| 116 |
+
- split: train
|
| 117 |
+
path: mid/instruct_nemotron_if_v3/train-*.parquet
|
| 118 |
+
- config_name: mid_instruct_nemotron_if_v2
|
| 119 |
+
data_files:
|
| 120 |
+
- split: train
|
| 121 |
+
path: mid/instruct_nemotron_if_v2/train-*.parquet
|
| 122 |
+
- config_name: sft_mix
|
| 123 |
+
data_files:
|
| 124 |
+
- split: train
|
| 125 |
+
path: sft/mix/train-*.parquet
|
| 126 |
+
- split: test
|
| 127 |
+
path: sft/mix/test-*.parquet
|
| 128 |
+
- config_name: sft_sequence_continuation
|
| 129 |
+
data_files:
|
| 130 |
+
- split: train
|
| 131 |
+
path: sft/sequence_continuation/train-*.parquet
|
| 132 |
+
- config_name: sft_variant_effect_prediction
|
| 133 |
+
data_files:
|
| 134 |
+
- split: train
|
| 135 |
+
path: sft/variant_effect_prediction/train-*.parquet
|
| 136 |
+
- config_name: sft_dna_computation
|
| 137 |
+
data_files:
|
| 138 |
+
- split: train
|
| 139 |
+
path: sft/dna_computation/train-*.parquet
|
| 140 |
+
- config_name: sft_sequence_classification
|
| 141 |
+
data_files:
|
| 142 |
+
- split: train
|
| 143 |
+
path: sft/sequence_classification/train-*.parquet
|
| 144 |
+
- config_name: sft_chat
|
| 145 |
+
data_files:
|
| 146 |
+
- split: train
|
| 147 |
+
path: sft/chat/train-*.parquet
|
| 148 |
+
- config_name: sft_sequence_analysis
|
| 149 |
+
data_files:
|
| 150 |
+
- split: train
|
| 151 |
+
path: sft/sequence_analysis/train-*.parquet
|
| 152 |
+
- config_name: sft_instruction_following
|
| 153 |
+
data_files:
|
| 154 |
+
- split: train
|
| 155 |
+
path: sft/instruction_following/train-*.parquet
|
| 156 |
+
- config_name: sft_biology_qa
|
| 157 |
+
data_files:
|
| 158 |
+
- split: train
|
| 159 |
+
path: sft/biology_qa/train-*.parquet
|
| 160 |
+
- config_name: rl_mix
|
| 161 |
+
data_files:
|
| 162 |
+
- split: train
|
| 163 |
+
path: rl/mix/train-*.parquet
|
| 164 |
+
---
|
| 165 |
+
|
| 166 |
+

|
| 167 |
+
|
| 168 |
+
# FineDNA
|
| 169 |
+
|
| 170 |
+
FineDNA is the training data of [Carbon-X](https://huggingface.co/HuggingFaceBio/Carbon-X), the model that taught
|
| 171 |
+
Qwen3-14B to read DNA, for all three of its training stages. Each stage is a group of configs:
|
| 172 |
+
|
| 173 |
+
| stage | configs | rows | starts from |
|
| 174 |
+
|---|---|---:|---|
|
| 175 |
+
| [Mid-training](#mid-training) | `mid_*`, one per source (23) | 514.30B tokens, of which the run read 302B | `Qwen/Qwen3-14B` |
|
| 176 |
+
| [SFT](#sft) | `sft_mix`, and `sft_*` for each of its 8 domains | 203,923 `train`, 100 `test` | `HuggingFaceBio/Carbon-X-Base` |
|
| 177 |
+
| [RL](#rl) | `rl_mix` | 98,433 `train` | `HuggingFaceBio/Carbon-X-SFT` |
|
| 178 |
+
|
| 179 |
+
`sft_mix` and `rl_mix` are the rows the SFT and GRPO trainers used, in the order they used them. Mid-training has no
|
| 180 |
+
single mix: Megatron samples the `mid_*` configs with the weights in [the mix](#the-mix) below.
|
| 181 |
+
|
| 182 |
+
```python
|
| 183 |
+
from datasets import load_dataset
|
| 184 |
+
|
| 185 |
+
# one mid-training source; the mid-training configs total about 950 GB, so stream them
|
| 186 |
+
ds = load_dataset("HuggingFaceBio/FineDNA", "mid_dna_mrna", split="train", streaming=True)
|
| 187 |
+
# the SFT mixture, or one of its domains
|
| 188 |
+
ds = load_dataset("HuggingFaceBio/FineDNA", "sft_mix")
|
| 189 |
+
ds = load_dataset("HuggingFaceBio/FineDNA", "sft_chat", split="train")
|
| 190 |
+
# the RL blend
|
| 191 |
+
ds = load_dataset("HuggingFaceBio/FineDNA", "rl_mix", split="train")
|
| 192 |
+
```
|
| 193 |
+
|
| 194 |
+
The training recipes for every stage are in [`huggingface/carbon`](https://github.com/huggingface/carbon/tree/main/carbon-x).
|
| 195 |
+
|
| 196 |
+
## Mid-training
|
| 197 |
+
|
| 198 |
+
The `mid_*` configs hold every source of the 302B-token mid-training run, one config per source: genomes and
|
| 199 |
+
transcripts, biology text that contains DNA, English web and PDF text, and instruction data. Their files are under
|
| 200 |
+
`mid/<source>/`.
|
| 201 |
+
|
| 202 |
+
Every config holds all the data Carbon-X sampled from for that source. That is not the whole upstream dataset: the
|
| 203 |
+
DNA, for example, is GENERator and OpenGenome2 after the filtering described below. The **share of training** column
|
| 204 |
+
below is the weight each config gets, and those weights are the recipe: they decide how much of each config the run
|
| 205 |
+
read, so some configs were read several times and some only in part. Tokenize the `text` column with the Carbon-X
|
| 206 |
+
tokenizer, train with these weights, and you get the same data diet as Carbon-X.
|
| 207 |
+
|
| 208 |
+
### The mix
|
| 209 |
+
|
| 210 |
+
| | unique tokens | share of training |
|
| 211 |
+
|---|---:|---:|
|
| 212 |
+
| DNA | 181.96B | 55% |
|
| 213 |
+
| Biology text | 15.75B | 15% |
|
| 214 |
+
| English | 310.22B | 20% |
|
| 215 |
+
| Instruction | 6.36B | 10% |
|
| 216 |
+
| **Total** | **514.30B** | **100%** |
|
| 217 |
+
|
| 218 |
+
Carbon-X trained on 302B of these 514.30B tokens. Long-DNA biology text was read about 7 times and
|
| 219 |
+
instruction data about 5; of English, prokaryote and mRNA-splice the run read only a part.
|
| 220 |
+
|
| 221 |
+
| config | documents | tokens | share of training (weight) | tokens read by Carbon-X | passes |
|
| 222 |
+
|---|---:|---:|---:|---:|---:|
|
| 223 |
+
| `mid_dna_eukaryote_fungi` | 6,607,490 | 1.88B | 1.12% | 3.37B | 1.79 |
|
| 224 |
+
| `mid_dna_eukaryote_protozoa` | 1,257,499 | 366.8M | 0.19% | 581.3M | 1.58 |
|
| 225 |
+
| `mid_dna_eukaryote_plant` | 9,429,321 | 5.55B | 3.08% | 9.30B | 1.68 |
|
| 226 |
+
| `mid_dna_eukaryote_invertebrate` | 8,716,932 | 13.71B | 7.58% | 22.90B | 1.67 |
|
| 227 |
+
| `mid_dna_eukaryote_vertebrate_mammalian` | 7,169,696 | 18.96B | 10.32% | 31.16B | 1.64 |
|
| 228 |
+
| `mid_dna_eukaryote_vertebrate_other` | 12,420,543 | 29.56B | 16.21% | 48.95B | 1.66 |
|
| 229 |
+
| `mid_dna_mrna` | 52,702,454 | 19.41B | 8.80% | 26.58B | 1.37 |
|
| 230 |
+
| `mid_dna_mrna_splice` | 56,877,102 | 32.93B | 2.20% | 6.64B | 0.20 |
|
| 231 |
+
| `mid_dna_prokaryote` | 17,408,059 | 59.60B | 5.50% | 16.61B | 0.28 |
|
| 232 |
+
| `mid_bio_p90_biorxiv` | 7,262 | 99.1M | 0.24% | 710.3M | 7.17 |
|
| 233 |
+
| `mid_bio_p90_biostars` | 2,036 | 3.1M | 0.01% | 25.4M | 8.19 |
|
| 234 |
+
| `mid_bio_p90_finepdfs` | 51,241 | 1.96B | 4.58% | 13.84B | 7.07 |
|
| 235 |
+
| `mid_bio_p90_fineweb` | 8,205 | 79.7M | 0.19% | 560.2M | 7.03 |
|
| 236 |
+
| `mid_bio_p90_pubmed` | 68,330 | 854.2M | 1.99% | 6.01B | 7.03 |
|
| 237 |
+
| `mid_bio_rest` | 914,391 | 12.16B | 7.00% | 21.14B | 1.74 |
|
| 238 |
+
| `mid_bio_gemini_fim` | 56,866 | 262.8M | 0.50% | 1.51B | 5.74 |
|
| 239 |
+
| `mid_bio_gemini_nonfim` | 72,343 | 333.4M | 0.50% | 1.51B | 4.53 |
|
| 240 |
+
| `mid_english_fineweb_edu` | 96,541,686 | 99.35B | 8.00% | 24.16B | 0.24 |
|
| 241 |
+
| `mid_english_dclm` | 88,340,007 | 111.98B | 8.00% | 24.16B | 0.22 |
|
| 242 |
+
| `mid_english_finepdfs_edu` | 17,596,723 | 98.89B | 4.00% | 12.08B | 0.12 |
|
| 243 |
+
| `mid_instruct_nemotron_chat_v3` | 562,376 | 2.25B | 3.53% | 10.67B | 4.75 |
|
| 244 |
+
| `mid_instruct_nemotron_if_v3` | 249,748 | 632.0M | 0.99% | 3.00B | 4.75 |
|
| 245 |
+
| `mid_instruct_nemotron_if_v2` | 1,997,510 | 3.48B | 5.47% | 16.53B | 4.75 |
|
| 246 |
+
|
| 247 |
+
*Tokens* is the config's size with the Carbon-X tokenizer (estimated from a 2,000-document sample per config).
|
| 248 |
+
*Tokens read by Carbon-X* is share x 302B. *Passes* is how many times over the run read the config: below 1, it read
|
| 249 |
+
only that fraction of it.
|
| 250 |
+
|
| 251 |
+
### How to train on it
|
| 252 |
+
|
| 253 |
+
1. Tokenize `text` with [`HuggingFaceBio/carbon-x`](https://huggingface.co/HuggingFaceBio/carbon-x). It detects DNA in
|
| 254 |
+
text and encodes it with its 6-mer DNA vocabulary. DNA configs already wrap sequences in `<dna>…</dna>`. To
|
| 255 |
+
tokenize a source straight from the Hub, read `hf://datasets/HuggingFaceBio/FineDNA/mid/<source>`.
|
| 256 |
+
2. Sample configs by the *share of training* column. In Megatron, that is the weight of each `--data-path` prefix.
|
| 257 |
+
Within a config, split its weight across shards in proportion to their size, so every document is equally likely.
|
| 258 |
+
3. Train for 302B tokens: 72,000 iterations at a global batch of 512 x 8,192 tokens, from the frozen-DNA-embedding
|
| 259 |
+
Qwen3-14B checkpoint (a short first stage that trains only the new DNA embeddings). The full recipe, including the vocabulary extension and that first stage, is in the
|
| 260 |
+
[Carbon-X midtraining recipe](https://github.com/huggingface/carbon/tree/main/carbon-x/training/midtraining).
|
| 261 |
+
Training longer with the same weights repeats the same data more often; for more unique DNA or English, add data
|
| 262 |
+
from the original datasets linked below.
|
| 263 |
+
|
| 264 |
+
### What is in it
|
| 265 |
+
|
| 266 |
+
**DNA (55%).** Eukaryote genomic windows from [GENERator](https://huggingface.co/datasets/GenerTeam/pretrain_data_eukaryote),
|
| 267 |
+
up to 100 kbp, in six species groups weighted by the corpus's natural distribution. mRNA, mRNA with splice and promoter
|
| 268 |
+
context, and prokaryote genomes (GTDB and IMG/PR) from [OpenGenome2](https://huggingface.co/datasets/arcinstitute/opengenome2).
|
| 269 |
+
All DNA configs are complete: they hold every sequence the run could sample from. Carbon-X read eukaryote and mRNA
|
| 270 |
+
more than once, and about 28% of prokaryote and
|
| 271 |
+
20% of mRNA-splice.
|
| 272 |
+
The raw sequences are also in [`HuggingFaceBio/carbon-pretraining-corpus`](https://huggingface.co/datasets/HuggingFaceBio/carbon-pretraining-corpus).
|
| 273 |
+
Here they are formatted exactly as they were trained on:
|
| 274 |
+
|
| 275 |
+
- every sequence is cut to a multiple of 6 bp (the tokenizer reads 6-mers) and wrapped in `<dna>…</dna>`;
|
| 276 |
+
- eukaryote sequences carry metadata tags half the time, chosen at random: species group and gene type, species group
|
| 277 |
+
only, or gene type only, e.g. `<mammalian_species><protein_coding_region><dna>ATG…</dna>`;
|
| 278 |
+
- mRNA and prokaryote sequences are uppercased, splice-junction markers (`@`) are removed, and mRNA longer than
|
| 279 |
+
100,000 bases is dropped.
|
| 280 |
+
|
| 281 |
+
**Biology text (15%).** Web pages, papers and forum posts that contain DNA, plus synthetic annotations. The web and
|
| 282 |
+
paper configs were built in two steps; the code is in [`mid/pipeline/`](https://huggingface.co/datasets/HuggingFaceBio/FineDNA/tree/main/mid/pipeline).
|
| 283 |
+
|
| 284 |
+
1. **Find documents that contain DNA:** [`1_regex_filter.py`](https://huggingface.co/datasets/HuggingFaceBio/FineDNA/blob/main/mid/pipeline/1_regex_filter.py). We ran a regex filter over
|
| 285 |
+
FineWeb-Edu, FinePDFs, PubMed Central, bioRxiv and Biostars. A document is kept when
|
| 286 |
+
- it has a run of 15 or more nucleotide letters (A, T, C, G, U, N) using at least 3 different ones,
|
| 287 |
+
- that run is not inside curly braces, which in scraped text is usually LaTeX, and
|
| 288 |
+
- it mentions a molecular-biology keyword (dna, gene, primer, pcr, ...).
|
| 289 |
+
2. **Split by DNA length:** [`2_p90_split.py`](https://huggingface.co/datasets/HuggingFaceBio/FineDNA/blob/main/mid/pipeline/2_p90_split.py), which finds DNA with
|
| 290 |
+
[`tag_dna_sequences.py`](https://huggingface.co/datasets/HuggingFaceBio/FineDNA/blob/main/mid/pipeline/tag_dna_sequences.py). Documents whose longest DNA sequence is at least 39 bp, the
|
| 291 |
+
90th percentile, form `mid_bio_p90_*`. Everything else forms `mid_bio_rest`. Short runs are mostly primers and motifs; the
|
| 292 |
+
p90 documents carry real sequences. In our ablations, training on them instead of every regex hit improved DNA
|
| 293 |
+
benchmarks, so in the mix they get as much weight as `mid_bio_rest` and are read about seven times.
|
| 294 |
+
|
| 295 |
+
| config | what it is |
|
| 296 |
+
|---|---|
|
| 297 |
+
| `mid_bio_p90_biorxiv`, `mid_bio_p90_biostars`, `mid_bio_p90_finepdfs`, `mid_bio_p90_fineweb`, `mid_bio_p90_pubmed` | documents with long DNA sequences, one config per source |
|
| 298 |
+
| `mid_bio_rest` | the other regex hits from the same five sources, whose longest DNA sequence is under 39 bp |
|
| 299 |
+
| `mid_bio_gemini_nonfim` | genomic regions described by Gemini next to their sequence |
|
| 300 |
+
| `mid_bio_gemini_fim` | the same kind of documents in Qwen's fill-in-the-middle format: part of each document is moved to the end, and the model learns to fill it in |
|
| 301 |
+
|
| 302 |
+
**English (20%).** [FineWeb-Edu](https://huggingface.co/datasets/HuggingFaceFW/fineweb-edu) (100BT sample),
|
| 303 |
+
[DCLM](https://huggingface.co/datasets/HuggingFaceFW/dclm_100BT-shuffled) and
|
| 304 |
+
[FinePDFs-Edu](https://huggingface.co/datasets/HuggingFaceFW/finepdfs_edu_100BT-shuffled), to keep the model's English.
|
| 305 |
+
|
| 306 |
+
**Instruction (10%).** [Nemotron Instruction-Following-Chat v3](https://huggingface.co/datasets/nvidia/Nemotron-SFT-Instruction-Following-Chat-v3)
|
| 307 |
+
(chat and instruction-following splits) and [v2](https://huggingface.co/datasets/nvidia/Nemotron-SFT-Instruction-Following-Chat-v2)
|
| 308 |
+
(chat), rendered with the Qwen3 chat template, reasoning traces kept. Mid-training starts from an instruct model, and
|
| 309 |
+
this keeps it able to follow instructions.
|
| 310 |
+
|
| 311 |
+
### How the mix matches the run
|
| 312 |
+
|
| 313 |
+
Every config was rebuilt from its source and checked against the document counts in the training run's log: each
|
| 314 |
+
holds everything the run sampled from for that source. How much of each the run read is set by the weights, as in the table above.
|
| 315 |
+
Where the run read only part of a config, which documents Megatron happened to draw cannot be recovered, but training
|
| 316 |
+
with the same weights draws the same amount from the same pool.
|
| 317 |
+
|
| 318 |
+
Two pieces of data are included although they never reached the run, so that the pools are complete:
|
| 319 |
+
1,720,988 documents of `mid_dna_eukaryote_invertebrate` and
|
| 320 |
+
1,726,948 of `mid_english_dclm`, from tokenization shards that were missing when Carbon-X
|
| 321 |
+
trained.
|
| 322 |
+
|
| 323 |
+
Biology configs also have a `validation` split: the documents held out of training to track loss.
|
| 324 |
+
|
| 325 |
+
### Columns
|
| 326 |
+
|
| 327 |
+
Every mid-training config has the same columns:
|
| 328 |
+
|
| 329 |
+
| column | |
|
| 330 |
+
|---|---|
|
| 331 |
+
| `text` | the document, as it was tokenized |
|
| 332 |
+
| `id` | the source's document id, where it has one |
|
| 333 |
+
| `source` | the config name without `mid_`, or for biology text the original source (`pubmed`, `biorxiv`, …) |
|
| 334 |
+
| `metadata` | the source's other fields, as a JSON string |
|
| 335 |
+
|
| 336 |
+
The `mid/` files are copied unchanged from [`HuggingFaceBio/FineDNA-Mid`](https://huggingface.co/datasets/HuggingFaceBio/FineDNA-Mid)
|
| 337 |
+
at revision `663538d6`.
|
| 338 |
+
|
| 339 |
+
## SFT
|
| 340 |
+
|
| 341 |
+
Supervised fine-tuning conversations for a DNA language model: 204,023 rows (203,923 `train`, 100 `test`) drawn
|
| 342 |
+
from 20 source datasets with the Carbon-X SFT mixture weights. `sft_mix` holds exactly the rows the SFT trainer builds
|
| 343 |
+
from that mixture (seed 0), so training on its `train` split reproduces the mixture without any further weighting.
|
| 344 |
+
|
| 345 |
+
Each domain also has its own config, `sft_<domain>`, holding the `sft_mix` `train` rows of that domain in the same
|
| 346 |
+
order, with no test split, e.g. `load_dataset("HuggingFaceBio/FineDNA", "sft_chat")`.
|
| 347 |
+
|
| 348 |
+
### Columns
|
| 349 |
+
|
| 350 |
+
- `messages`: the conversation, as a list of `{role, content}` turns.
|
| 351 |
+
- `chat_template_kwargs`: `{"tokenizer_kwargs": {"auto_dna_tags": <bool>}}`, passed per example to
|
| 352 |
+
`apply_chat_template` so the DNA tokenizer wraps sequences in `<dna>...</dna>`. It is `false` only for the sequence
|
| 353 |
+
rewriting rows, whose answers are plain text. Keep it when selecting training columns.
|
| 354 |
+
- `domain`: the kind of task, one of the eight below.
|
| 355 |
+
|
| 356 |
+
### Domains
|
| 357 |
+
|
| 358 |
+
| config | train | test (in `sft_mix`) | what the rows teach |
|
| 359 |
+
| --- | ---: | ---: | --- |
|
| 360 |
+
| `sft_sequence_continuation` | 58,727 | 27 | predict the next 1–32 nucleotides after a 4–8 kb eukaryotic context |
|
| 361 |
+
| `sft_variant_effect_prediction` | 57,254 | 24 | decide whether a single-nucleotide variant is benign or pathogenic from its sequence window, with templated reasoning |
|
| 362 |
+
| `sft_dna_computation` | 44,925 | 25 | answers computed exactly from the sequence: counting, GC content, melting temperature, translation, restriction sites, base lookup, coordinates, edits, rewriting |
|
| 363 |
+
| `sft_sequence_classification` | 16,396 | 11 | multiple-choice functional genomics: promoter vs enhancer, species of origin, TF motifs, TF binding sites |
|
| 364 |
+
| `sft_chat` | 8,553 | 6 | multi-turn conversations on molecular-biology concepts, the assistant's identity, honesty about its limits, and pushing back on false claims |
|
| 365 |
+
| `sft_sequence_analysis` | 7,561 | 3 | free-text, mostly multi-turn discussion of a pasted sequence: primer checks, annotation, coding potential, troubleshooting |
|
| 366 |
+
| `sft_instruction_following` | 5,904 | 1 | answering in the format the user asks for, and following format constraints on biology prompts |
|
| 367 |
+
| `sft_biology_qa` | 4,603 | 3 | genetics, molecular biology and bioinformatics questions from Biology StackExchange, Biostars, real user chats and Nemotron chat data |
|
| 368 |
+
|
| 369 |
+
### Sources
|
| 370 |
+
|
| 371 |
+
Every source is the `_decontaminated_ngram_dna_homology` variant of the config below, `train` split. Each is shuffled
|
| 372 |
+
with seed 0 and truncated to `int(rows × weight)`; the result is concatenated, shuffled with seed 0 and split into
|
| 373 |
+
`train` and a 100-row `test` set with seed 0.
|
| 374 |
+
|
| 375 |
+
| dataset | config | revision | rows | weight | rows used | domain |
|
| 376 |
+
| --- | --- | --- | ---: | ---: | ---: | --- |
|
| 377 |
+
| `HuggingFaceBio/sequence-recovery-qa` | `varlen` | `e09cae72` | 58,754 | 1.0 | 58,754 | `sequence_continuation` |
|
| 378 |
+
| `HuggingFaceBio/sequence-recovery-qa` | `rewrite` | `e09cae72` | 24,730 | 0.1266728 | 3,132 | `dna_computation` |
|
| 379 |
+
| `HuggingFaceBio/carbon-format-if` | `format_if_v2` | `390592d0` | 5,196 | 1.0 | 5,196 | `instruction_following` |
|
| 380 |
+
| `HuggingFaceBio/basic-dna-sft-data-v3` | `all_diversify_30pct` | `72dc7e73` | 63,848 | 0.151 | 9,641 | `dna_computation` |
|
| 381 |
+
| `HuggingFaceBio/carbon-sequence-contextfree-v8-regex-10k` | `final` | `5f17e938` | 10,000 | 0.3 | 3,000 | `sequence_analysis` |
|
| 382 |
+
| `HuggingFaceBio/carbon-gemini-repair-sft` | `default` | `63cccfc7` | 11,907 | 0.3 | 3,572 | `sequence_analysis` |
|
| 383 |
+
| `HuggingFaceBio/carbon-sequence-contextfree-v6-1000` | `final` | `e2792417` | 992 | 1.0 | 992 | `sequence_analysis` |
|
| 384 |
+
| `HuggingFaceBio/carbon-bioSE-sft` | `final` | `31dc6d39` | 2,072 | 1.0 | 2,072 | `biology_qa` |
|
| 385 |
+
| `HuggingFaceBio/carbon-biostars-sft-v2` | `final` | `5014a6b6` | 1,327 | 1.0 | 1,327 | `biology_qa` |
|
| 386 |
+
| `HuggingFaceBio/wild-bio-prompts-luna-generated-verified-v1` | `final` | `35440c49` | 842 | 1.0 | 842 | `biology_qa` |
|
| 387 |
+
| `HuggingFaceBio/seqqa2-luna-sft-structurednotags-dna8-clean-v3` | `final` | `38644f1f` | 853 | 1.0 | 853 | `dna_computation` |
|
| 388 |
+
| `HuggingFaceBio/genomeqa-sft` | `enhancer_promoter_diversify_10pct` | `398703a5` | 10,559 | 0.4 | 4,223 | `sequence_classification` |
|
| 389 |
+
| `HuggingFaceBio/genomeqa-sft` | `eukaryote_cls_diversify_10pct` | `398703a5` | 9,143 | 0.4 | 3,657 | `sequence_classification` |
|
| 390 |
+
| `HuggingFaceBio/genomeqa-sft` | `tf_motif_diversify_10pct` | `398703a5` | 13,058 | 0.4 | 5,223 | `sequence_classification` |
|
| 391 |
+
| `HuggingFaceBio/genomeqa-sft` | `tfbs_diversify_10pct` | `398703a5` | 8,262 | 0.4 | 3,304 | `sequence_classification` |
|
| 392 |
+
| `HuggingFaceBio/vepqa-sft-draft-loubna` | `templated_reasoning_multiview_v2_all` | `76e39513` | 74,484 | 0.769 | 57,278 | `variant_effect_prediction` |
|
| 393 |
+
| `HuggingFaceBio/nemotron-data-filtered-carbon` | `biology_en_max8704` | `50df980c` | 3,656 | 0.1 | 365 | `biology_qa` |
|
| 394 |
+
| `HuggingFaceBio/nemotron-data-filtered-carbon` | `instruction_following_bio_en_max8704` | `50df980c` | 709 | 1.0 | 709 | `instruction_following` |
|
| 395 |
+
| `HuggingFaceBio/easy-dna-chat-v2` | `all` | `53923d9a` | 11,502 | 0.7442 | 8,559 | `chat` |
|
| 396 |
+
| `HuggingFaceBio/carbon-dna-skills` | `all` | `d703e0cd` | 39,156 | 0.8 | 31,324 | `dna_computation` |
|
| 397 |
+
|
| 398 |
+
`carbon-format-if` rows reuse examples from basic-dna, seqqa2 and sequence-recovery `varlen` with a format instruction
|
| 399 |
+
added, so they are labelled by purpose (`instruction_following`) rather than content.
|
| 400 |
+
|
| 401 |
+
### Reproducing
|
| 402 |
+
|
| 403 |
+
The `sft/` files are copied unchanged from [`HuggingFaceBio/FineDNA-SFT`](https://huggingface.co/datasets/HuggingFaceBio/FineDNA-SFT)
|
| 404 |
+
at revision `400d761b`, which was built with:
|
| 405 |
+
|
| 406 |
+
```bash
|
| 407 |
+
python sft/scripts/create_dataset.py --output_dataset HuggingFaceBio/FineDNA-SFT
|
| 408 |
+
```
|
| 409 |
+
|
| 410 |
+
[`sft/scripts/create_dataset.py`](sft/scripts/create_dataset.py) pins the full revision of every source above and needs
|
| 411 |
+
read access to them (all are private). Its output matches the trainer's mixture loader row for row on both splits.
|
| 412 |
+
|
| 413 |
+
The domain configs are then split from the mixture's `train` split at revision `60b6e0d5`:
|
| 414 |
+
|
| 415 |
+
```bash
|
| 416 |
+
python sft/scripts/create_subset.py --dataset HuggingFaceBio/FineDNA-SFT --revision 60b6e0d5c9af34bd97de521cc2cf5fb3e977771c
|
| 417 |
+
```
|
| 418 |
+
|
| 419 |
+
## RL
|
| 420 |
+
|
| 421 |
+
Verifiable prompts for reinforcement learning of a DNA language model: 98,433 rows in one `train` split, covering
|
| 422 |
+
80,406 distinct prompts. Every prompt has a gold answer or constraint set that a reward function checks in code. The
|
| 423 |
+
blend was calibrated on rollouts from Carbon-X-SFT and excludes the prompts that model saw during SFT. It is meant for
|
| 424 |
+
one epoch. The rows of `rl_mix` are in the order the GRPO trainer's mixture loader produces (seed 0), so training on it
|
| 425 |
+
reproduces the blend exactly.
|
| 426 |
+
|
| 427 |
+
Some prompts appear more than once on purpose, for groups that learn slowly under RL: `basic_dna` repeats half of each
|
| 428 |
+
task type (10,153 second copies), `bioreason` repeats 30% of each subgroup and label (4,614), and `dna_skills` repeats
|
| 429 |
+
every prompt (3,260).
|
| 430 |
+
|
| 431 |
+
### Columns
|
| 432 |
+
|
| 433 |
+
- `prompt`: the conversation to complete, as a list of `{role, content}` turns (2,983 rows open with a system turn).
|
| 434 |
+
- `answer_text`: the gold answer that most rewards compare against.
|
| 435 |
+
- `task_group`: which reward scores the row. Each task reward returns `None` for rows of other groups.
|
| 436 |
+
- `task_type`: the sub-task, used by the `basic_dna` and `seqrecqa_position` rewards (null elsewhere).
|
| 437 |
+
- `verifier_metadata`: the constraints an instruction-following reply must meet (`if` rows only).
|
| 438 |
+
- `gold_answer_json`: the exact answer the DNA-skills verifier checks (`dna_skills` rows only).
|
| 439 |
+
- `domain`: the kind of task. It uses the same labels as the SFT domains. Five of the eight occur here because the
|
| 440 |
+
blend has no chat, sequence-analysis or sequence-continuation prompts.
|
| 441 |
+
|
| 442 |
+
### Task groups
|
| 443 |
+
|
| 444 |
+
| domain | task group | rows | what the prompts ask |
|
| 445 |
+
| --- | --- | ---: | --- |
|
| 446 |
+
| `dna_computation` | `basic_dna` | 30,461 | short-sequence computations with code-checked answers: base counts, melting temperature, restriction fragments, CRISPR cut sites, translation, motif spacing |
|
| 447 |
+
| `dna_computation` | `dna_skills` | 6,520 | exact operations on longer sequences: locate a base or snippet, convert coordinates, compare, edit, translate, design |
|
| 448 |
+
| `dna_computation` | `seqrecqa_position` | 6,000 | localisation: the position of a base, 6-base block, variant block, 12-base span, single-base difference or snippet |
|
| 449 |
+
| `variant_effect_prediction` | `bioreason` | 19,996 | is a coding-sequence or non-SNV variant pathogenic or benign |
|
| 450 |
+
| `variant_effect_prediction` | `vepqa` | 7,426 | is a single-nucleotide variant pathogenic or benign, judged from its sequence window |
|
| 451 |
+
| `sequence_classification` | `genomeqa` | 14,032 | multiple-choice functional genomics: promoter vs enhancer, species of origin, TF motifs and binding sites, splice sites, histone marks |
|
| 452 |
+
| `biology_qa` | `bio_mcq` | 9,998 | four- and ten-option biology knowledge questions |
|
| 453 |
+
| `instruction_following` | `if` | 4,000 | prompts with verifiable formatting constraints |
|
| 454 |
+
|
| 455 |
+
In total, `dna_computation` has 42,981 rows, `variant_effect_prediction` 27,422, `sequence_classification` 14,032,
|
| 456 |
+
`biology_qa` 9,998 and `instruction_following` 4,000.
|
| 457 |
+
|
| 458 |
+
### Source
|
| 459 |
+
|
| 460 |
+
| dataset | config | revision | rows |
|
| 461 |
+
| --- | --- | --- | ---: |
|
| 462 |
+
| `HuggingFaceBio/Rollouts-Carbon-14B-SFT-v36.52-step-000019119` | `blend_all_v0` | `205d8b22` | 98,433 |
|
| 463 |
+
|
| 464 |
+
Only the six columns the trainer reads are kept, and `domain` is added from `task_group`. The rows are shuffled twice
|
| 465 |
+
with seed 0, matching the trainer's mixture loader (once per source, once after concatenation).
|
| 466 |
+
|
| 467 |
+
### Reproducing
|
| 468 |
+
|
| 469 |
+
The `rl/` files are copied unchanged from [`HuggingFaceBio/FineDNA-RL`](https://huggingface.co/datasets/HuggingFaceBio/FineDNA-RL)
|
| 470 |
+
at revision `2315ddc7`, which was built with:
|
| 471 |
+
|
| 472 |
+
```bash
|
| 473 |
+
python rl/scripts/create_dataset.py --output_dataset HuggingFaceBio/FineDNA-RL
|
| 474 |
+
```
|
| 475 |
+
|
| 476 |
+
[`rl/scripts/create_dataset.py`](rl/scripts/create_dataset.py) pins the full source revision and needs read access to
|
| 477 |
+
it (the source is private). Its output matches the trainer's mixture loader row for row.
|
| 478 |
+
|
| 479 |
+
## License
|
| 480 |
+
|
| 481 |
+
Each mid-training config keeps the license and terms of its source: GENERator, OpenGenome2, FineWeb-Edu, DCLM,
|
| 482 |
+
FinePDFs-Edu, PubMed Central, bioRxiv, Biostars, and Nemotron. The SFT and RL rows are built from the sources listed in
|
| 483 |
+
their sections. Check the source dataset before use.
|