PMID
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35.7M
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36,275,738
exosom tumor microenviron promot cancer progress exosom extracellular vesicl produc endosom import perform intercellular communic function three decad grow awar exosom content tumor microenviron intim connect develop cancer composit generat uptak exosom well role tumor metastasi angiogenesi immunosuppress discuss paper...
D055354;D009369
T026;T191
36,275,737
comprehens investig cuproptosi character clinic featur molecular characterist immun situat clear cell renal cell carcinoma copper induc cell death wide investig human diseas form program cell death pcd newli recogn mechan under copper induc cell death provid us creativ insight copper relat toxic cell form pcd term cupr...
D002292;D007680
T191
36,275,736
chang urinari proteom quadrival influenza vaccin covid vaccin proteom urin sampl quadrival influenza vaccin cohort analyz self contrast method signific chang urin protein hour vaccin enrich immun relat pathway although person specif pathway vari specul may differ peopl differ immunolog background associ influenza urin ...
D007252;D000086382
T129;T121;T067;T109;T047
36,275,735
possibl role gut microb host immun respons gut lung homeostasi vast divers microbi communiti resid various locat human bodi collect name human microbiota major microb found gastrointestin respiratori tract microorgan present gastrointestin respiratori tract call gut microbiota airway microbiota respect microbi communit...
D000069196;D000086382
T067;T047;T007;T001
36,275,733
establish chemokin relat prognost gene signatur prostat cancer implic anti androgen immunotherapi prostat cancer pca one common malign among men prognosi pca patient poor especi patient recurr advanc diseas
D011471
T191
36,275,732
histamin induc high mobil group box releas vascular endotheli cell h receptor system allerg reaction character vasodil vascular leakag caus rapid precipit sustain decreas arteri blood pressur concomit decreas cardiac output histamin major mediat releas mast cell allerg inflamm respons caus cascad inflamm strong increas...
D000707;D006632
T121;T123;T109;T047;T046
36,275,731
chronovaccin har circadian rhythm optim immunis strategi vaccin public health measur offer effect protect popul infecti diseas optimis vaccin efficaci particular higher risk individu like elder whose immunocompromis state prevent develop robust vaccin respons vital clear hour circadian rhythm govern virtual aspect phys...
D000086382;D014612
T129;T121;T116;T067;T047
36,275,730
case report chronic hepat e hematopoiet stem cell transplant recipi first report hepat e virus genotyp caus chronic infect non solid organ recipi hepat e virus hev one import public health issu around world chronic hev infect report immunosuppress individu studi report male case sever aplast anemia aa develop chronic h...
D016752;D016751;D018380
T061;T005;T047
36,275,729
identifi lactic acid metabol relat gene signatur contribut predict prognosi immunotherapi efficaci tumor microenviron lung adenocarcinoma lactic acid consid endpoint wast metabolit glycolysi emerg major regul cancer develop mainten progress howev studi lactic acid metabol relat gene lrgs lung adenocarcinoma luad remain...
D008175;D000077192
T191
36,275,728
phenotyp spectrum recess sting associ vasculopathi onset infanc four novel case analysi previous report case gain function variant stimul interferon respons cgamp interactor sting gene caus sting associ vasculopathi onset infanc savi previous heterozyg most de novo sting variant report caus savi interest one variant le...
D014652;D017445
T047
36,275,727
target tumor microenviron innat cell immunosuppress tumor microenviron tme remain one prevail barrier obstruct implement effect immunotherapi solid state cancer emin compos immunosuppress tumor associ macrophag tam myeloid deriv suppressor cell mdscs among other tme attenu effect immun checkpoint blockad adopt cell the...
D059016;D000076962
T129;T070;T116;T192
36,275,726
case report success challeng report gls zimberelimab novel fulli human mab pd case recurr endometri cancer widespread use immun checkpoint inhibitor ici grow concern report immun relat advers event ira clinic practic patient experi sever toxic ici base therapi would requir utmost caution resum ici therapi potenti risk ...
D000074322;D016889
T129;T121;T191;T116
36,275,724
comparison neoadjuv immunotherapi plus chemotherapi versus chemotherapi alon patient local advanc esophag squamous cell carcinoma propens score match clinic studi immun checkpoint inhibitor ici combin neoadjuv chemotherapi nct carri resect esophag squamous cell carcinoma escc far studi compar surviv outcom nct plus ici...
D000077277;D004938
T191
36,275,723
role allergen specif igg subclass block human basophil activ success treatment ige mediat allergi allergen specif immunotherapi ait usual correl induct allergen specif igg howev clear whether igg prevent allerg reaction effici igg subclass aim compar allergen specif monoclon igg igg antibodi capac inhibit type allerg r...
D006967;D006969
T046
36,275,722
necroptosi relat prognost model pancreat cancer base singl cell sequenc analysi transcriptom analysi tumor type high mortal poor therapeut effect pathogenesi pancreat cancer still unclear necessari explor signific necroptosi pancreat cancer
D000079302;D010190
T191;T043
36,275,721
identifi novel ferroptosi relat prognost score predict prognosi chronic lymphocyt leukemia chronic lymphocyt leukemia cll common leukemia western world although treatment landscap cll rapid evolv still patient develop drug resist diseas refractori ferroptosi type lipid peroxid induc cell death suggest prognost valu sev...
D015451;D000079403
T191;T043
36,275,720
origin activ target therapi glioma associ macrophag glioma tumor microenviron play crucial role develop occurr treatment glioma glioma associ macrophag gam wide infiltr immun cell tumor microenviron tme one major cell popul exert immun function gam typic origin two cell type brain resid microglia brm bone marrow deriv ...
D001932;D005910
T191
36,275,719
associ interferon base therapi risk autoimmun diseas patient chronic hepat c virus infect popul base taiwanes cohort studi interferon combin ribavirin standard care chronic hepat c virus infect hcv past decad howev effect risk autoimmun diseas ad among patient hcv infect remain unclear assess potenti associ interferon ...
D019698;D006526;D050031;D006111
T047
36,275,718
tpi promot metastasi glioma via macrophag neutrophil fibroblast potenti prognost biomark tpi protein code tumor suppress gene encod tumor protein p overexpress tpi imped tumor cell prolifer nevertheless tpi role express emerg progress glioma low grade glioma glioblastoma yet identifi thus aim use comprehens bioinformat...
D001932;D005910
T191
36,275,717
regulatori cell garp express decreas exercis associ chikungunya viral arthriti flare chikungunya virus chikv caus persist arthriti prior studi show approxim one third chikv arthriti patient exacerb arthriti associ exercis under mechan exercis associ chikungunya arthriti flare eacaf unknown analysi aim examin regulatori...
D065632;D002646;D001168
T047;T005
36,275,716
lipidom insight immun respons pearl format transplant pearl oyster pinctada fucata martensii pearl cultur excess immun respons may induc nucleus reject death pearl oyster transplant better understand immun respons pearl format lipidom analysi appli investig chang serum lipid profil pearl oyster pinctada fucata martensi...
D049911
T204
36,275,715
case report cd direct car cell therapi combin btk inhibitor pd antibodi secondari central nervous system lymphoma current therapeut strategi central nervous system cns relaps diffus larg b cell lymphoma dlbcl extrem limit secondari central nervous system lymphoma scnsl also show grave prognosi high mortal report descri...
D016543;D016403;D016609;D000076962
T129;T191;T116;T192
36,275,714
aquaporin posit neuromyel optica spectrum disord meningoenceph like onset case report neuromyel optica spectrum diseas nmosd debilit autoimmun inflammatori demyelin diseas central nervous system relationship harbor infect nmosd current unclear need investig articl report meningoenceph like manifest includ fever headach...
D009471;D008582;D009902;D008590
T047
36,275,713
human innat lymphoid cell activ adenovirus modifi host defens protein neutral antibodi innat lymphoid cell ilc complement divers cd helper cell help maintain tissu homeostasi provid link innat adapt immun respons pioneer studi last decad advanc understand ilc influenc adapt immun respons pathogen far less known whether...
D007113;D008214
T032;T025
36,275,712
reduc farnesyl diphosph synthas level activ vv cell improv tumor suppress murin xenograft cancer model human vv cell attract candid cancer immunotherapi due potent capac tumor recognit cytolysi mani tumor cell type howev effort deploy clinic strategi vv cell cancer therapi hamper insuffici potenc pursu altern strategi ...
D006528;D008113
T191
36,275,711
lipid cd til benefici harm lipid lipid metabol play crucial role regul cell function tight relat establish immun memori report tumor infiltr cd lymphocyt cd til burn fat restor impair effector function due lack glucos convers fatti acid fas cholesterol tumor microenviron tme drive cd til dysfunct origin dysfunct cd til...
D018414;D009369
T191;T025
36,275,710
rogu neutrophil subset desprcdbcdb immunotyp action therapeut target neutrophil inflamm mediat tissu injuri studi human macaqu rat lps inflamm model correl rs neutrophil express dual endothelinsign peptid receptor desprcdbcdb sever hypoxemia sf ratio multi organ failur sofa score patient acut respiratori distress syndr...
D055371;D012128;D001927
T047;T037
36,275,709
case report system muscl involv primari clinic manifest chronic activ epstein barr virus infect case base review chronic activ epstein barr virus infect caebv common asian countri character recurr persist infecti mononucleosi like symptom describ rare case caebv associ general myositi extranod nkt cell lymphoma initi p...
D020031;D017285;D009220
T047
36,275,708
absolut quantif character oxylipin lupus nephriti system lupus erythematosus system lupus erythematosus sle chronic autoimmun diseas multi organ inflamm defect link mani molecul mediat oxylipin class lipid mediat broad investig sle appli target mass spectrometri analysi screen alter oxylipin serum sle patient healthi c...
D008181;D008180
T047
36,275,707
grk inhibitor paroxetin ccg attenu ige mediat anaphylaxi activ mast cell via mrgprx mrgprb g protein coupl receptor gpcr kinas grk phosphoryl agonist occupi gpcrs promot desensit investig attract therapeut target cardiovascular metabol diseas sever grk target inhibit strategi report includ use direct pharmacolog inhibi...
D008407;D000707
T047;T046;T025
36,275,706
stress cancer mechan immun dysregul manag advanc understand psychoneuroimmunolog past decad emphas notion stress cancer interlink close durabl chronic stress acceler tumorigenesi progress unfavor clinic outcom cancer patient avail evid provid unpreced knowledg role mechan chronic stress carcinogenesi well known one dys...
D013315;D009369
T191;T048
36,275,705
gldc mitig mir e regul cell prolifer tumor immun infiltr tnbc tnbc whose clinic prognosi poorer subgroup breast cancer malign tumor character lack estrogen receptor progesteron hormon receptor overexpress due lack specif target drug crucial identifi critic factor involv regul progress tnbc
D064726;D035683
T123;T191;T114
36,275,704
self reactiv cd cell clone determin differenti status rather respons infect matur cell select recogn self antigen low intermedi affin thymus recent relat differ self reactiv among individu cell clone appreci import factor regul fate immun respons role self reactiv cell biolog incomplet understood address role self reac...
D018414;D007370
T129;T121;T025;T116
36,275,703
matrix metalloproteinas contribut intestin barrier dysfunct degrad tight junction protein claudin previous studi implic matrix metalloproteinas mmps mmp inflammatori bowel diseas ibd show increas activ inflamm gut howev pathophysiolog role mmp clear elucid
D003092;D015212;D003093
T047
36,275,702
sever covid patient display hyper activ nk cell nk cell platelet aggreg covid characteris broad spectrum clinic patholog featur natur killer nk cell play import role innat immun respons viral infect analys phenotyp activ nk cell blood covid patient use flow cytometri singl cell rna sequenc scrna seq cytotox kill assay ...
D000086382
T047;T067
36,275,701
identifi potenti pharmacolog target mechan vitamin hepatocellular carcinoma covid coronavirus diseas covid sever pandem pose unpreced challeng public health worldwid hepatocellular carcinoma hcc common digest system malign high aggress poor prognosi hcc patient may vulner covid sinc anti inflammatori immunomodulatori a...
D006528;D008113;D000086382;D035683
T123;T067;T191;T114;T047
36,275,700
epstein barr virus interleukin multipl sclerosi mnage troi multipl sclerosi ms autoimmun diseas character inflamm demyelin nerv cell strong evid epstein barr virus ebv human herpesvirus infect b cell great increas risk subsequ ms intrigu ebv induc human interleukin also encod homologu molecul key anti inflammatori cyto...
D020031;D009103;D011345
T121;T047;T109
36,275,699
ucp silenc restrain leukemia cell prolifer glutamin metabol remodel cell acut lymphoblast leukemia aggress hematolog malign deriv earli cell progenitor sinc relaps associ poor prognosi improv initi treatment patient essenti avoid resist select initi develop metastasi even respons chemotherapi tumor cell face strong met...
D005973;D054218
T123;T121;T191;T116
36,275,698
intrapleur infus tumor cell deriv microparticl packag methotrex salin combin pemetrex cisplatin chemotherapi treatment malign pleural effus advanc non squamous non small cell lung cancer doubl blind random placebo control studi preclinc studi show promis efficaci tumor cell deriv microparticl packag methotrex tmps mtx ...
D002289;D016066;D055252;D008175;D000970
T026;T121;T109;T191;T047
36,275,697
molecular subtyp base wnt signal gene express predict prognosi tumor microenviron hepatocellular carcinoma base increas research evid hepatocellular carcinoma hcc heterogen genet profil led identif multipl subtyp diseas advanc knowledg abil use individu medicin treatment hcc essenti perform complet method character var...
D006528;D008113
T191
36,275,696
diverg sar cov specif cell respons intens care unit worker follow mrna covid vaccin cellular immun respons sever acut respiratori syndrom coronavirus sar cov respons full mrna covid vaccin could variabl among healthi individu studi base specif antibodi level could show erron immun protect long time analyz antibodi leve...
D000086382;D014765
T129;T047;T121;T067
36,275,695
cytokin level associ favor clinic outcom capsid random trial convalesc plasma patient sever covid determin profil cytokin patient sever covid enrol trial covid convalesc plasma ccp
D016207;D000086382
T129;T047;T116;T067
36,275,694
psycholog stress inflammatori bowel diseas psychoneuroimmunolog insight bidirect gut brain communic inflammatori bowel diseas ibd main includ ulcer coliti uc crohn diseas cd autoimmun gastrointestin diseas character chronic inflamm frequent recurr accumul evid confirm chronic psycholog stress consid trigger ibd deterio...
D011598;D015212
T047;T091
36,275,693
b h target fc optim antibodi induct nk cell reactiv sarcoma natur killer nk cell larg contribut antibodi depend cellular cytotox adcc central factor success monoclon antibodi mab treatment cancer b famili member b h cd recent receiv intens interest novel promis target antigen immunotherapi b h high express mani tumor e...
D007694;D012509
T191;T025
36,275,691
self sampl identifi pathogen inflammatori marker patient acut sore throat feasibl studi sore throat common reason overus antibiot valu inflammatori biomark throat swab saliva sampl predict benefit antibiot unknown
D000086382;D010612
T184;T047;T067
36,275,690
identif microsatellit instabl immun relat prognost biomark colon adenocarcinoma colon adenocarcinoma coad preval malign caus signific mortal microsatellit instabl play pivot function coad develop immunotherapi resist howev detail under mechan requir investig consequ identifi molecular biomark prognost signific reveal r...
D003110;D000230
T191
36,275,689
develop function regulatori innat lymphoid cell innat lymphoid cell ilc critic element innat immun system potent produc pro inflammatori cytokin recent howev product anti inflammatori cytokin il observ ilc subtyp ilc ilc ilc suggest abil adopt regulatori phenotyp serv maintain lung gut homeostasi studi advoc potenti th...
D007113;D001249
T047;T032
36,275,688
case report senesc mechan resist pembrolizumab lymphoma patient fail cd target car cell therapi cell engin target cd antigen neoplast b cell repres strike exampl car cell therapi success rate therapi affect sever limit target antigen loss andor acquisit senescentexhaust phenotyp car non car cell
D000076962;D016403
T129;T191;T116;T192
36,275,687
complement cs diagnost marker therapeut target progress propect molecul complement system connect effector innat adapt immun play critic role maintain homeostasi among c complex compos cq cr cs cqr initi classic complement activ pathway defici cs associ earli onset system lupus erythematosus increas suscept bacteria in...
D003173;D015923
T129;T126;T116
36,275,686
regulatori role kca immun cell function emerg associ rheumatoid arthriti rheumatoid arthriti ra common autoimmun diseas character chronic inflamm immun dysfunct essenti mechan pathogenesi ra direct link synovi inflamm cartilagebon destruct intermedi conduct ca activ k channel kca consid signific regul prolifer differen...
D001172;D001169
T047;T050
36,275,685
cell kinet reveal expans distinct lung cell subset acut versus resolv influenza virus infect influenza virus infect restrict airway associ tissu elicit cellular humor respons ultim result generat memori cell abl initi rapid immun respons infect resid memori cell confer protect site infect lung resid memori cell import ...
D053118;D007251;D009976
T005;T047
36,275,684
hn bear mutat nucleoprotein lead increas patholog chicken zoonot hn avian influenza ai virus first emerg low pathogen lpai strain repeat caus human infect result sever respiratori ill mortal death across five epidem wave virus circul poultri littl discern clinic sign make detect control difficult contrari publish data ...
D005585;D064766
T047;T005
36,275,683
inhibit mrgprx fcri mrgprb mediat mast cell degranul small molecul invers receptor agonist mas relat g protein coupl receptor x mrgprx express mast cell mcs contribut hypersensit reaction cation us food drug administr fda approv drug neuromuscular block agent rocuronium addit activ mrgprx neuropeptid substanc p sp pro ...
D009479;D004342
T123;T046;T116
36,275,682
uveiti increas risk stroke among patient ankylos spondyl nationwid popul base longitudin studi ankylos spondyl known increas risk stroke among patient uveiti common extra articular manifest howev previous investig discuss associ uveiti risk develop stroke patient retrospect cohort studi aim explor relationship uveiti i...
D013167;D014605;D020521
T047
36,275,680
defici c reactiv protein human c reactiv protein transgen treatment aggrav influenza infect mice c reactiv protein crp shown potenti candid target immunotherapi sever influenza infect howev unclear pathogenesi associ crp influenza infect use influenza hn ca infect human crp transgen mice ki crp knockout mice ko wild ty...
D007251;D053118
T047;T005
36,275,679
hexosamin biosynthesi pathway relat gene signatur correl immun infiltr predict prognosi patient osteosarcoma osteosarcoma malign bone tumor poor outcom affect adolesc elder studi comprehens assess metabol characterist osteosarcoma patient construct hexosamin biosynthesi pathway hbp base risk score model predict prognos...
D012516;D001859
T191
36,275,678
astrocyt regul vascular endotheli respons simul deep space radiat human organ chip model central nervous system cns damag galact cosmic ray radiat major health risk human deep space explor simul galact cosmic ray compon especi high z high energi particl fe ion caus neurodegener neuroinflamm rodent model cns damag parti...
D001253;D056656
T025;T075
36,275,677
system wide identif myeloid marker tb diseas hiv induc reactiv macaqu model mtb infect mtbsiv co infect mycobacterium tuberculosi mtb develop special mechan parasit host cell macrophag mechan allow overcom kill oxid burst persist wake inflammatori respons mtb infect major expos control asymptomat form refer latent tube...
D016097;D060085;D055985;D015302;D016180;D015658;D007370
T129;T121;T116;T005;T047
36,275,676
identif cell senesc molecular subtyp predict prognosi immunotherapi hepat b virus relat hepatocellular carcinoma hepat b virus hbv infect hepatocellular carcinoma hcc high incid fatal rate worldwid among preval cancer grow bodi data indic cellular senesc cs critic factor hepatocarcinogenesi predict valu cs hbv relat hc...
D006528;D008113
T191
36,275,675
reveal novel autophagi relat gene ligamentum flavum hypertrophi patient mice model fibrosi core patholog factor ligamentum flavum hypertrophi lfh result degen lumbar spinal stenosi autophagi play vital role multi organ fibrosi howev autophagi report involv pathogenesi lfh
D017843
T023
36,275,674
mechan unconvent cd tc lymphocyt induct allerg contact dermat role h h histamin receptor histamin ha potent mediat play central role inflamm allergi act four g protein coupl receptor ie h h ha accept promot type immun cd cell hypersensit previous demonstr ha promot antigen cross present induc activ antigen specif cd ce...
D006632;D017449
T123;T047;T121;T109
36,275,673
immunogen cell death driver autoimmun granulomatosi polyangi cell death dysregul clearanc dead cell play essenti role induct chronic inflammatori process autoimmun diseas granulomatosi polyangi gpa neutrophil driven autoimmun disord character necrot inflamm predomin respiratori tract anti neutrophil cytoplasm autoantib...
D014890;D024243;D001327;D007960
T123;T047;T116
36,275,672
longitudin cellular humor immun respons tripl bntb fourth full dose mrna vaccin haemodialysi patient haemodialysi patient respond poor vaccin continu risk sever covid therefor dialysi patient among first fourth covid vaccin recommend howev target inform best maintain immun protect sar cov vaccin risk group sever covid ...
D000086382;D014765
T129;T047;T121;T067
36,275,671
prospect approach enhanc car cell therapi glioblastoma glioblastoma gbm common malign brain tumor poor clinic outcom overal ineffect current standard treatment includ surgeri chemotherapi radiat highlight urgent need altern tumor specif therapi gbm chimer antigen receptor car cell therapi revolutionari therapeut strate...
D005909;D000076962;D001932
T129;T191;T116;T192
36,275,670
tumor microenviron featur deciph outperform neoadjuv immunochemotherapi chemotherapi resect non small cell lung cancer studi evalu efficaci neoadjuv immunochemotherapi iochemo versus chemotherapi alon chemo resect non small cell lung cancer nsclc real world set associ tumor immun microenviron time patholog respons diff...
D002289;D008175
T191
36,275,669
efficaci evalu multi immunotherapi ovarian cancer bench bed ovarian cancer one common gynecolog malign character high mortal poor prognosi cytoreduct surgeri chemotherapi remain mainstay ovarian cancer treatment women experi recurr standard care therapi compel evid ovarian cancer immunogen tumor exampl accumul tumor in...
D019496;D010051
T129;T121;T191;T116
36,275,668
tissu resid memori cell new benchmark induct vaccin induc mucos immun histor gold standard benchmark vaccin immunogen induct neutral antibodi detect serum peripher blood howev recent year new appreci mucosa import site vaccin induc immun point first contact mucos tissu repres major site immun base detect restrict patho...
D018928;D007252
T129;T121;T109;T042
36,275,667
print ti cu alloy acceler osteogen differenti mct e cell stimul phenotyp polar macrophag ti cu alloy prove excel mechan properti cell compat certain antibacteri properti due addit cu howev studi effect ti cu alloy macrophag polar immun relat bone format studi prepar ti cu alloy three dimension print technolog found ti ...
D010012;D000497
T197;T042
36,275,666
strategi overcom dc dysregul tumor microenviron dendrit cell dcs play key role modul anti cancer immun tumor microenviron tme link innat adapt immun process present tumor antigen cell therebi initi anti tumor respons howev subset dcs also induc immun toler lead tumor immun escap regard tme play major role advers affect...
D019496;D009369
T129;T121;T191;T116
36,275,665
prognost impact control nutrit status score patient hematolog malign systemat review meta analysi increas number studi valid prognost signific control nutrit status conut score patient solid tumor howev extent correl conut score clinic outcom patient hematolog malign unclear
D009369;D019337
T191
36,275,664
identif character agingsenesc induc gene osteosarcoma predict clinic prognosi age influenti risk factor progress degen oncolog diseas bone osteosarcoma consid common primari mesenchym tumor bone worldwid diseas poor year surviv studi investig role age senesc induc gene asig contribut osteosarcoma diagnosi prognosi ther...
D012516;D001859
T191
36,275,663
coronavirus diseas vaccin uptak hesit among polish patient inborn error immun autoinflammatori syndrom rheumat diseas multicent survey data regard willing patient affect inborn error immun accept vaccin sever acut respiratori syndrom coronavirus sar cov infect limit therefor studi assess sar cov vaccin coverag hesit im...
D000086382;D012216;D014612;D056660;D000081207
T129;T121;T116;T067;T047
36,275,662
atyp hemolyt urem syndrom trigger mrna vaccin sar cov case report atyp hemolyt urem syndrom ahus also call complement mediat hemolyt urem syndrom cm hus rare diseas caus dysregul altern complement activ pathway life threaten condit caus ischemia number organ typic caus acut kidney injuri disord may trigger various fact...
D065766;D000086382;D058186
T047;T037;T067
36,275,661
genom wide associ studi snp gene base approach identifi suscept candid lupus nephriti han chines popul lupus nephriti ln one common serious complic system lupus erythaematosus sle genet factor play import role pathogenesi ln could use predict might develop ln purpos studi screen suscept candid ln across whole genom han...
D008181
T047
36,275,660
comprehens comput analysi reveal yxx ilmfv motif yxx like tetrapeptid across hfrs caus hantavirus associ viral pathogenesi host immun regul hemorrhag fever renal syndrom hfrs acut zoonot diseas transmit aerosol excrement rodent etiolog hfrs complex due involv viral factor host immun genet factor viral speci domin caus ...
D006480;D006476;D018063
T047;T005
36,275,659
turn new pattern identif cancer associ fibroblast relat cluster tnbc grow evid indic connect cancer associ fibroblast caf tumor microenviron tme remodel tumor progress nevertheless pattern caf impact tme immunotherapi respons tripl negat breast cancer tnbc remain unclear systemat investig relationship tnbc progress pat...
D064726;D000072645
T191;T025
36,275,658
lipid metabol type diabet mellitus pathogenet therapeut implic type diabet mellitus tdm chronic autoimmun diseas insulin defici due pancreat cell destruct multipl independ cohort studi reveal specif lipid spectrum alter prior islet autoimmun tdm except serv build block membran biogenesi accumul evid suggest lipid deriv...
D003922
T047
36,275,657
spectral flow cytometri cluster analysi therapeut donor lymphocyt infus identifi cell subset associ outcom patient aml relaps identif immun phenotyp link durabl graft versus leukemia gvl respons follow donor lymphocyt infus dli high clinic relev prospect observ studi aml relaps patient receiv therapeut dli longitudin i...
D006086;D015470
T047;T191
36,275,656
retrospect studi correl herp zoster neuralgia serum neuron specif enolas level largest dermatolog hospit zhejiang provinc china studi chang clinic signific serum neuron specif enolas nse level peripher blood patient post herpet neuralgia phn
D006562;D051474;D009437
T184;T047
36,275,655
comparison blood lymph node cell intramuscular inject hiv envelop immunogen har cd cell help lymph node ration antigen design could enhanc format broad neutral antibodi bnab experiment hiv immun process remain hidden due difficulti direct studi clinic studi instead focus respons blood proxi secondari lymphoid tissu
D016915;D015658
T129;T047;T121
36,275,654
macrophag autophagi macrophag polar chronic inflamm organ fibrosi essenti regul organ fibrosi macrophag undergo mark phenotyp function chang organ injuri chang macrophag phenotyp function result maladapt repair caus chronic inflamm develop patholog fibrosi autophagi high conserv lysosom degrad pathway one major player ...
D066329;D008264
T116;T025
36,275,653
clinic relev vitamin b level vitamin b metabol gene variat pulmonari tuberculosi aim studi assess associ vitamin b level singl nucleotid polymorph snps vitamin b metabol gene pulmonari tuberculosi ptb chines han popul plasma vitamin b express level detect use elisa ten snps six key gene tcn tcn cubn mmachc fut mut vita...
D014397;D007019
T047
36,275,652
effect dietari clostridium autoethanogenum protein growth diseas resist intestin digest immun microbiota structur litopenaeus vannamei rear differ water salin shortag fishmeal fm resourc limit healthi develop aquacultur develop new protein sourc replac fm aquat feed effect measur allevi situat howev applic effect new p...
D033561;D000069196
T001;T007;T204
36,275,650
bet v display elastin like polypeptid nanoparticl induc strong humor weak cd cell respons bet v murin immunogen model grow concern toxic colloid aluminum salt use adjuv subcutan allergen immunotherapi scit therefor altern adjuv deliveri system explor replac alum scit appli micellar elastin like polypeptid elp type self...
D052179;D053758
T129;T073
36,275,649
rare complic anti melanoma differenti associ gene antibodi posit dermatomyos time nip bud anti melanoma differenti associ gene antibodi posit dermatomyos mda dm infrequ autoimmun diseas main distribut asian femal mda dm usual present various skin lesion posit anti mda antibodi myositi specif autoantibodi amyopath hypom...
D003882;D009220
T047
36,275,647
gastric alarmin releas warn signal develop gastric mucos diseas alarmin exist outsid cell earli warn signal immun system alarmin receptor wide distribut various immun cell alarmin proinflammatori molecular pattern associ tissu damag usual releas extracellular space induc immun respons particip damag repair process muco...
D024243;D005756
T123;T047;T116
36,275,646
integr profil endoplasm reticulum stress relat derl prognost immun featur lung adenocarcinoma derl implic essenti element degrad misfold lumen glycoprotein induc endoplasm reticulum er stress howev correl derl express malign phenotyp lung adenocarcinoma luad cell unclear remain elucid herein investig interact derl luad...
D000077192;D008175
T191
36,275,645
costimul express human endotheli cell modul antigen depend recruit circul lymphocyt endotheli cell ec present antigen circul effector memori cell em regulatori cell reg trigger antigen specif extravas specif site foreign antigen introduc eg infect transplant model human antigen induc transendotheli migrat tem use prese...
D042783;D018106
T129;T116;T025;T192
36,275,644
novel cell senesc relat incrna surviv model associ tumor immun environ colorect cancer long noncod rnas major role tumorigenesi develop metastasi colorect cancer crc particip regul cell senesc relat prognosi crc therefor import valid cell senesc relat lncrnas correl prognosi crc
D062085;D015179
T123;T191;T114
36,275,643
target nanoparticl modifi neutrophil function vivo neutrophil play critic role broad spectrum clinic condit accord manipul neutrophil function may provid power immunotherapeut approach howev due neutrophil characterist short half life larg popul number possibl consid impract describ identif peptid specif bind either mu...
D009504;D053758
T025;T073
36,275,642
transcriptom rrna analysi reveal respons largemouth bass micropterus salmoid rhabdovirus infect better understand respons largemouth bass micropterus salmoid micropterus salmoid rhabdovirus msrv infect investig intestin bacteri flora transcriptom profil fish hour post infect hpi total differenti express gene deg identi...
D001492;D018353;D012209
T047;T005;T013
36,275,641
nlrp inflammasom nlrp relat autoinflammatori diseas cryopyrin function target therapi nlrp inflammasom one nod like receptor famili member function character act key player innat immun system particip sever physiolog process includ among other modul immun system respons coordin host defenc activ inflammasom crucial sig...
D000071199;D056587
T123;T047;T116
36,275,640
postop neutrophil lymphocyt ratio predict unfavor outcom acut ischem stroke patient achiev complet reperfus thrombectomi approxim half anterior circul larg vessel occlus lvo patient receiv endovascular treatment evt favor outcom aim studi explor associ dynam inflammatori marker ie neutrophil lymphocyt ratio nlr measur ...
D000083242;D057510
T061;T047
36,275,639
associ immunosuppress poor antibodi respons sar cov vaccin patient autoimmun liver diseas antibodi b cell respons inactiv sar cov vaccin well document patient autoimmun liver diseas aild therefor conduct prospect observ studi includ aild patient healthi particip control juli septemb second affili hospit chongq medic un...
D000086382;D001327;D008107
T033;T047;T067
36,275,483
ultrasound respons smart implant hydrogel target deliveri drug review current practic last two decad process deliv therapeut drug patient control releas profil signific focus drug deliveri research scientist given tremend attent ultrasound respons hydrogel sever decad smart nanosystem applic stimuli respons drug delive...
D020100;D016503
T122;T074
36,275,482
carbon dot deriv os draconi anxiolyt effect present peopl suscept develop depress anxieti disord respons stress howev specif medicin anxieti os draconi od name long gu chines fossil bone use tradit chines medicin treat neurolog diseas thousand year thus conduct studi determin biolog basi anxiolyt effect od
D014151
T121;T039
36,275,481
earli assess atherosclerot lesion vulner plaqu vivo target apoptot macrophag av nanobubbl earli detect atherosclerot lesion particular import risk predict acut cardiovascular event macrophag apoptosi signific associ degre lesion especi contribut plaqu vulner research main sought explor feasibl home made av nanobubbl nb...
D058226;D050197
T047;T046;T020;T031
36,275,480
acid respons ir base target nanoparticl intraop near infrar fluoresc imag ovarian cancer complet resect visibl diseas r resect critic treatment ovarian cancer patient accur real time guidanc provid intraop near infrar nir fluoresc imag benefici achiev complet resect visibl diseas
D053758;D010051
T191;T073
36,275,479
zinc oxid particl caus ovarian toxic oxid stress femal mice model zinc oxid nanoparticl zno nps particip aspect live wide applic disadvantag expos goal studi investig toxic zno nps femal mice ovari explor potenti mechan
D015034;D053758
T121;T197;T073
36,275,478
ros generat poli ethylen glycol conjug fe nanoparticl cancer target sustain releas carrier doxorubicin site specif drug deliveri system contribut develop execut effect cancer treatment due favor featur includ high biocompat high hydrophil eas function poli ethylen glycol peg wide adopt design drug carrier generat carri...
D000970;D053758;D009369
T121;T191;T073;T109