interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR006610 | 6,610 | Domain of unknown function DM7 | DM7 | Domain | 52 | false | false | This domain of unknown function has been found in a number of Drosophila proteins that belong to DM7 family. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF27651",
"SM00688"
] | [
"DM7",
"DM7"
] | [
52,
52
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Drosophilinae"
] | [
52
] | 1 | [
"Drosophila melanogaster"
] | [
9
] | 1 | true | Domain | Domain of unknown function DM7 | Domain of unknown function DM7 | DM7 | 7 |
IPR006611 | 6,611 | Protein of unknown function DUF1431, cysteine-rich, Drosophila | DUF1431_DROsp | Family | 480 | false | false | This cysteine-rich family of proteins has currently only been identified in Drosophila species. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER",
"SMART"
] | [
"PF07248",
"PTHR20977",
"SM00689"
] | [
"DUF1431",
"",
"DM6"
] | [
479,
363,
362
] | 3 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Neoptera"
] | [
480
] | 1 | [
"Drosophila melanogaster"
] | [
16
] | 1 | true | Family | Protein of unknown function DUF1431, cysteine-rich, Drosophila | Protein of unknown function DUF1431, cysteine-rich, Drosophila | DUF1431_DROsp | 8 |
IPR006612 | 6,612 | THAP-type zinc finger | THAP_Znf | Domain | 35,915 | false | false | The THAP-type zinc finger (consensus: C-x(2,4)-C-x(35,50)-C-x(2)-H) is an ~90-residue domain restricted to animals, which is shared between the THAP family of cellular DNA-binding proteins, and transposases from mobile genomic parasites [ , ]. THAP1, the prototype of the THAP family, possesses zinc-dependent sequence-s... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART",
"SMART"
] | [
"PF05485",
"PS50950",
"SM00692",
"SM00980"
] | [
"THAP",
"ZF_THAP",
"DM3",
"THAP"
] | [
34312,
34174,
21794,
30224
] | 4 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50950",
"R-CEL-3769402",
"R-CEL-4641265",
"R-CEL-9764725",
"R-DME-3214847",
"R-DME-6804759",
"R-DME-9772755"
] | [
"PROSITEDOC:PDOC50950",
"REACTOME:R-CEL-3769402",
"REACTOME:R-CEL-4641265",
"REACTOME:R-CEL-9764725",
"REACTOME:R-DME-3214847",
"REACTOME:R-DME-6804759",
"REACTOME:R-DME-9772755"
] | 7 | [
"2d8r",
"2jm3",
"2jtg",
"2ko0",
"2l1g",
"2lau",
"3kde",
"6p5a",
"6pe2"
] | 9 | [
"PUB00016961",
"PUB00016962",
"PUB00048076",
"PUB00060550"
] | [
"12575992",
"12717420",
"18073205",
"15863623"
] | [
"The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase.",
"THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies.",
"Structure-function analysis of the THAP zinc finger of THAP1, a large C2CH DNA-binding ... | [
2003,
2003,
2008,
2005
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
35913,
2
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
127,
24,
36,
15,
20
] | 6 | true | Domain | THAP-type zinc finger | THAP-type zinc finger | THAP_Znf | 9 |
IPR006614 | 6,614 | Peroxin/Ferlin domain | Peroxin/Ferlin | Domain | 10,950 | false | false | These two closely linked domains are found in ferlin gene family members and in peroxisomal membrane proteins (peroxins). The function of the domains is unknown. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"SMART",
"SMART"
] | [
"SM00693",
"SM00694"
] | [
"DysFN",
"DysFC"
] | [
9448,
9453
] | 2 | [
"REACTOME"
] | [
"R-HSA-445355"
] | [
"REACTOME:R-HSA-445355"
] | 1 | [
"2k2o",
"4cah",
"4cai",
"8p5p",
"9b8k",
"9b8l",
"9h6x",
"9qkv",
"9qle",
"9qlf",
"9qln",
"9qls"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
10950
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
3,
50,
1,
8,
18,
2,
19,
4,
2
] | 9 | true | Domain | Peroxin/Ferlin domain | Peroxin/Ferlin domain | Peroxin/Ferlin | 1 |
IPR006615 | 6,615 | Peptidase C19, ubiquitin-specific peptidase, DUSP domain | Pept_C19_DUSP | Domain | 18,352 | false | false | Deubiquitinating enzymes (DUB) form a large family of cysteine protease that can deconjugate ubiquitin or ubiquitin-like proteins (see ) from ubiquitin-conjugated proteins. All DUBs contain a catalytic domain surrounded by one or more subdomains, some of which contribute to target recognition. The ~120-residue DUSP (do... | [
"GO:0004843"
] | [
"cysteine-type deubiquitinase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF06337",
"PS51283",
"SM00695"
] | [
"DUSP",
"DUSP",
"DUSP"
] | [
17027,
18120,
15106
] | 3 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.19.12",
"R-BTA-5357786",
"R-BTA-5357905",
"R-BTA-5357956",
"R-BTA-5689880",
"R-BTA-9010553",
"R-DRE-5689880",
"R-HSA-2173788",
"R-HSA-390471",
"R-HSA-5357786",
"R-HSA-5357905",
"R-HSA-5357956",
"R-HSA-5689603",
"R-HSA-5689880",
"R-HSA-9010553",
"R-MMU-5357786",
"R-MMU-5357905",
... | [
"EC:3.4.19.12",
"REACTOME:R-BTA-5357786",
"REACTOME:R-BTA-5357905",
"REACTOME:R-BTA-5357956",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-9010553",
"REACTOME:R-DRE-5689880",
"REACTOME:R-HSA-2173788",
"REACTOME:R-HSA-390471",
"REACTOME:R-HSA-5357786",
"REACTOME:R-HSA-5357905",
"REACTOME:R-HSA-535... | 26 | [
"1w6v",
"3jyu",
"3lmn",
"3ppa",
"3pv1",
"3t9l",
"4a3o",
"4a3p",
"4mel",
"4mem",
"5ctr",
"5jjw",
"5ok6",
"6dj9"
] | 14 | [
"PUB00038034"
] | [
"16298993"
] | [
"Solution structure of the human ubiquitin-specific protease 15 DUSP domain."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
3,
18349
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
22,
3,
18,
4,
29,
25,
1,
8,
28,
1,
2,
45
] | 12 | true | Domain | Peptidase C19, ubiquitin-specific peptidase, DUSP domain | Peptidase C19, ubiquitin-specific peptidase, DUSP domain | Pept_C19_DUSP | 1 |
IPR006616 | 6,616 | DM9 repeat | DM9_repeat | Repeat | 5,757 | false | false | This repeat of unknown function was identified in Diptera proteins; later on, it was also found in a wide range of invertebrates and vertebrates [ ], such as natterin [ , ]. It is often present in proteins comprising only two or four DM9 repeats and occasionally is linked to other domains at its N-or C-terminal. In the... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF11901",
"SM00696"
] | [
"DM9",
"DM9"
] | [
5556,
4850
] | 2 | [] | [] | [] | 0 | [
"5id8",
"5ida",
"5idb",
"5mh0",
"5mh1",
"5mh2",
"5mh3",
"8je9",
"8jea",
"8jeb"
] | 10 | [
"PUB00056184",
"PUB00101198",
"PUB00101199",
"PUB00101200",
"PUB00101201"
] | [
"16054523",
"29238341",
"27377186",
"33242570",
"34437409"
] | [
"Natterins, a new class of proteins with kininogenase activity characterized from Thalassophryne nattereri fish venom.",
"DM9 Domain Containing Protein Functions As a Pattern Recognition Receptor with Broad Microbial Recognition Spectrum.",
"Identification, Characterization, and X-ray Crystallographic Analysis ... | [
2005,
2017,
2016,
2021,
2021
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
152,
5605
] | 2 | [
"Drosophila melanogaster"
] | [
16
] | 1 | true | Repeat | DM9 repeat | DM9 repeat | DM9_repeat | 2 |
IPR006619 | 6,619 | Peptidoglycan recognition protein family domain, metazoa/bacteria | PGRP_domain_met/bac | Domain | 16,448 | false | false | This domain is found in a family of animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme [ ], and some bacterial homologues. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cyto... | [
"GO:0008270",
"GO:0008745",
"GO:0009253"
] | [
"zinc ion binding",
"N-acetylmuramoyl-L-alanine amidase activity",
"peptidoglycan catabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"SMART"
] | [
"SM00701"
] | [
"PGRP"
] | [
16448
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6798695",
"R-BTA-6803157",
"R-DME-209171",
"R-DME-209266",
"R-DME-214397",
"R-DME-214399",
"R-DME-214411",
"R-DME-214416",
"R-DME-6798695",
"R-DME-6803157",
"R-HSA-6798695",
"R-HSA-6803157",
"R-MMU-6798695",
"R-MMU-6803157",
"R-RNO-6798695",
"R-RNO-6803157"
] | [
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-6803157",
"REACTOME:R-DME-209171",
"REACTOME:R-DME-209266",
"REACTOME:R-DME-214397",
"REACTOME:R-DME-214399",
"REACTOME:R-DME-214411",
"REACTOME:R-DME-214416",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-6803157",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HS... | 16 | [
"1aro",
"1lba",
"1oht",
"1s2j",
"1sk3",
"1sk4",
"1sxr",
"1twq",
"1yck",
"1z6i",
"2aph",
"2cb3",
"2eav",
"2eax",
"2f2l",
"2r2k",
"2r90",
"2rkq",
"2xz4",
"2xz8",
"2z9n",
"3c2x",
"3cg9",
"3cor",
"3cxa",
"3ep1",
"3ng4",
"3nno",
"3nw3",
"3o4k",
"3ogx",
"3qj1"... | 73 | [
"PUB00009690",
"PUB00009691"
] | [
"9707603",
"9660837"
] | [
"A peptidoglycan recognition protein in innate immunity conserved from insects to humans.",
"Molecular cloning and characterization of the mouse tag7 gene encoding a novel cytokine."
] | [
1998,
1998
] | 2 | [
"IPR002502"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanosarcina mazei",
"Viruses",
"metagenomes"
] | [
9090,
6671,
3,
584,
100
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
36,
4,
11,
15
] | 5 | true | Domain | Peptidoglycan recognition protein family domain, metazoa/bacteria | Peptidoglycan recognition protein family domain, metazoa/bacteria | PGRP_domain_met/bac | 6 |
IPR006620 | 6,620 | Prolyl 4-hydroxylase, alpha subunit | Pro_4_hyd_alph | Domain | 62,487 | false | false | Mammalian prolyl 4-hydroxylase alpha catalyses the posttranslational formation of 4-hydroxyproline in -xaa-pro-gly-sequences in collagens and other proteins. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as... | [
"GO:0005506",
"GO:0016705",
"GO:0031418"
] | [
"iron ion binding",
"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen",
"L-ascorbic acid binding"
] | [
"molecular_function",
"molecular_function",
"molecular_function"
] | 3 | [
"SMART"
] | [
"SM00702"
] | [
"P4Hc"
] | [
62487
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"1.14.11",
"1.14.11.-",
"PWY-102",
"PWY-1187",
"PWY-5035",
"PWY-5036",
"PWY-5047",
"PWY-5070",
"PWY-5349",
"PWY-6085",
"PWY-6086",
"PWY-6495",
"PWY-6682",
"PWY-6915",
"PWY-6919",
"PWY-7150",
"PWY-7151",
"PWY-7232",
"PWY-7274",
"PWY-7298",
"PWY-7398",
"PWY-7419",
"PWY-7517... | [
"EC:1.14.11",
"EC:1.14.11.-",
"METACYC:PWY-102",
"METACYC:PWY-1187",
"METACYC:PWY-5035",
"METACYC:PWY-5036",
"METACYC:PWY-5047",
"METACYC:PWY-5070",
"METACYC:PWY-5349",
"METACYC:PWY-6085",
"METACYC:PWY-6086",
"METACYC:PWY-6495",
"METACYC:PWY-6682",
"METACYC:PWY-6915",
"METACYC:PWY-6919",... | 53 | [
"2g19",
"2g1m",
"2hbt",
"2hbu",
"2jig",
"2jij",
"2v4a",
"2y33",
"2y34",
"3dkq",
"3gze",
"3hqr",
"3hqu",
"3itq",
"3kt1",
"3kt4",
"3kt7",
"3mgu",
"3ouh",
"3oui",
"3ouj",
"4bqw",
"4bqx",
"4bqy",
"4iw3",
"4j25",
"4jzr",
"4kbz",
"4nhk",
"4nhl",
"4nhm",
"4nhx"... | 125 | [
"PUB00007742"
] | [
"11276424"
] | [
"The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases."
] | [
2001
] | 1 | [
"IPR005123"
] | [
"IPR044862"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
12,
15260,
46394,
562,
259
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
96,
10,
90,
57,
1,
58,
39,
7,
46,
72,
1,
1,
74
] | 13 | true | Domain | Prolyl 4-hydroxylase, alpha subunit | Prolyl 4-hydroxylase, alpha subunit | Pro_4_hyd_alph | 2 |
IPR006621 | 6,621 | Nose resistant-to-fluoxetine protein, N-terminal | Nose-resist-to-fluoxetine_N | Domain | 7,505 | false | false | This is the N-terminal domain of Caenorhabditis elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4) proteins; the domain is also present in several other worm and fly proteins. NRF-6 and NDG-4 are multipass transmembrane proteins which may act together in a complex to fun... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF20146",
"SM00703"
] | [
"NRF",
"NRF"
] | [
7451,
6422
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009693"
] | [
"10488330"
] | [
"Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7505
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
3,
23,
2,
4
] | 5 | true | Domain | Nose resistant-to-fluoxetine protein, N-terminal | Nose resistant-to-fluoxetine protein, N-terminal | Nose-resist-to-fluoxetine_N | 3 |
IPR006623 | 6,623 | Testicular haploid expressed repeat | THEG | Repeat | 1,693 | false | false | Repeats found in the Mus musculus (Mouse) and Homo sapiens (Human) THEG (testicular haploid expressed gene) proteins and several Drosophila melanogaster (Fruit fly) proteins [ ]. This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed ... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF14912",
"SM00705"
] | [
"THEG",
"THEG"
] | [
1617,
1528
] | 2 | [] | [] | [] | 0 | [
"8otz",
"8snb",
"9fqr"
] | 3 | [
"PUB00009694",
"PUB00067772",
"PUB00067773"
] | [
"11173852",
"10330110",
"12748127"
] | [
"Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG).",
"A novel testicular haploid expressed gene (THEG) involved in mouse spermatid-sertoli cell interaction.",
"Male mice lacking the Theg (testicular haploid expressed gene) protein undergo n... | [
2000,
1999,
2003
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
3,
1690
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
5,
2,
3,
8
] | 5 | true | Repeat | Testicular haploid expressed repeat | Testicular haploid expressed repeat | THEG | 4 |
IPR006624 | 6,624 | Beta-propeller repeat TECPR | Beta-propeller_rpt_TECPR | Repeat | 6,434 | false | false | Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) which encode 217 and 353 amino acids, respectively. Tectonin I is homologous to the C-terminal two-thirds of tectonin II. Both proteins contain six tandem repeats that are each 33-37 amino ... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"SMART"
] | [
"PF06462",
"PF19193",
"SM00706"
] | [
"Hyd_WA",
"Tectonin",
"TECPR"
] | [
3314,
4138,
6210
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3108214",
"R-HSA-5693565",
"R-HSA-5693571",
"R-HSA-5693607",
"R-HSA-69473",
"R-HSA-983168",
"R-MMU-3108214",
"R-MMU-5693565",
"R-MMU-5693571",
"R-MMU-5693607",
"R-MMU-69473",
"R-MMU-983168"
] | [
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-5693565",
"REACTOME:R-HSA-5693571",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-69473",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-3108214",
"REACTOME:R-MMU-5693565",
"REACTOME:R-MMU-5693571",
"REACTOME:R-MMU-5693607",
"REACTOME:R-MMU-69473",
"REACTOME:R-M... | 12 | [
"4ruq",
"4rus",
"5fsb",
"5fsc"
] | 4 | [
"PUB00007974",
"PUB00094379"
] | [
"9497393",
"22342342"
] | [
"Cloning and characterization of Physarum polycephalum tectonins. Homologues of Limulus lectin L-6.",
"A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate."
] | [
1998,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"metagenomes"
] | [
614,
5807,
4,
9
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
18,
1,
7,
8,
12
] | 6 | true | Repeat | Beta-propeller repeat TECPR | Beta-propeller repeat TECPR | Beta-propeller_rpt_TECPR | 9 |
IPR006627 | 6,627 | TDU repeat | TDU_repeat | Repeat | 3,712 | false | false | The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Scalloped (Sd) interacts with Vestigial (Vg) to ... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00711"
] | [
"TDU"
] | [
3712
] | 1 | [] | [] | [] | 0 | [
"4ln0",
"6y20"
] | 2 | [
"PUB00007975"
] | [
"10518497"
] | [
"TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Haloplanus aerogenes"
] | [
3711,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
13,
4,
9,
7,
6
] | 6 | true | Repeat | TDU repeat | TDU repeat | TDU_repeat | 2 |
IPR006628 | 6,628 | Purine-rich element binding protein family | PUR-bd_fam | Family | 7,183 | false | false | The purine-rich element binding (Pur) protein family protein consists of DNA-binding proteins from animals, plants and bacteria, including PURalpha/beta/gamma from humans, Pur-alpha 1 from Arabidopsis thaliana and Transcriptional/translational repressor BpuR from Borreliella burgdorferi. Human Pur-alpha is a highly con... | [
"GO:0000977",
"GO:0032422"
] | [
"RNA polymerase II transcription regulatory region sequence-specific DNA binding",
"purine-rich negative regulatory element binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"PFAM",
"PANTHER",
"SMART"
] | [
"PF04845",
"PF11680",
"PTHR12611",
"SM00712"
] | [
"PurA",
"DUF3276",
"",
"PUR"
] | [
4723,
2442,
4606,
6440
] | 4 | [] | [] | [] | 0 | [
"3k44",
"3n8b",
"3nm7",
"5fgo",
"5fgp",
"8cht",
"8chu",
"8chv",
"8chw"
] | 9 | [
"PUB00007976",
"PUB00015571",
"PUB00103947",
"PUB00154499",
"PUB00154500",
"PUB00154501"
] | [
"1448097",
"12894583",
"20976240",
"23846702",
"23974034",
"31240776"
] | [
"Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein.",
"The Pur protein family: clues to function from recent studies on cancer and AIDS.",
"Of bits and bugs--on the use of bioinformatics and a bacterial crystal structure to solve a... | [
1992,
2003,
2010,
2013,
2013,
2019
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2510,
4630,
43
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
2,
6,
5,
9,
6,
4,
10,
10
] | 9 | true | Family | Purine-rich element binding protein family | Purine-rich element binding protein family | PUR-bd_fam | 6 |
IPR006629 | 6,629 | LPS-induced tumour necrosis factor alpha factor | LITAF | Domain | 11,579 | false | false | LITAF (LPS-induced TNF-activating factor) (also known as SIMPLE; small integral membrane protein of the late endosome) is an endosome-associated integral membrane protein important for multivesicular body (MVB) sorting. It is a monotypic membrane protein with both termini exposed to the cytoplasm and is anchored to mem... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF10601",
"PS51837",
"SM00714"
] | [
"zf-LITAF-like",
"LITAF",
"LITAF"
] | [
11498,
10934,
10603
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00087092",
"PUB00087093"
] | [
"27582497",
"27927196"
] | [
"The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein.",
"The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C."
] | [
2016,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Natrialba aegyptia DSM 13077",
"Viruses",
"ecological metagenomes"
] | [
24,
11519,
1,
32,
3
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
2,
14,
14,
31,
10,
5,
2,
8,
7
] | 9 | true | Domain | LPS-induced tumour necrosis factor alpha factor | LPS-induced tumour necrosis factor alpha factor | LITAF | 9 |
IPR006630 | 6,630 | La-type HTH domain | La_HTH | Domain | 25,633 | false | false | This domain is found at the N terminus of La RNA-binding proteins as well as other proteins [ ]. Human Ro ribonucleoproteins (RNPs) are composed of one of the four small Y RNAs and at least two proteins, Ro60 and La. The La protein is a 47kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythema... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF05383",
"PS50961",
"SM00715"
] | [
"La",
"HTH_LA",
"LA"
] | [
24344,
25511,
24984
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50961",
"R-HSA-73980",
"R-HSA-749476",
"R-HSA-9705671"
] | [
"PROSITEDOC:PDOC50961",
"REACTOME:R-HSA-73980",
"REACTOME:R-HSA-749476",
"REACTOME:R-HSA-9705671"
] | 4 | [
"1s29",
"1s7a",
"1yty",
"1zh5",
"2cqk",
"2m5w",
"2mtf",
"2vod",
"2von",
"2voo",
"2vop",
"3htx",
"4wkr",
"6d6v",
"6i9b",
"7lma",
"7lmb",
"7slp",
"7slq",
"7soo",
"7sop",
"7soq",
"7sor",
"7sos",
"7sot",
"7sou",
"7sov",
"7sow",
"7uy5",
"7uy6",
"8ey6",
"8ey7"... | 40 | [
"PUB00003341",
"PUB00011367",
"PUB00014753",
"PUB00014754",
"PUB00014755",
"PUB00014760",
"PUB00014761"
] | [
"7799435",
"8035818",
"15016896",
"14636586",
"14690589",
"15004549",
"15048103"
] | [
"A yeast RNA binding protein that resembles the human autoantigen La.",
"La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth.",
"A peptide from autoantigen La blocks poliovirus and hepatitis C virus cap-independent translation an... | [
1995,
1994,
2004,
2003,
2003,
2004,
2004
] | 7 | [] | [
"IPR034946"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanocalculus chunghsingensis",
"ecological metagenomes"
] | [
8,
25622,
1,
2
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
49,
4,
51,
14,
49,
27,
2,
38,
31,
3,
2,
82
] | 12 | true | Domain | La-type HTH domain | La-type HTH domain | La_HTH | 2 |
IPR006631 | 6,631 | Protein of unknown function DM4/12 | DM4_12 | Family | 4,770 | false | false | This domain of unknown function is found in primarily in Drosophila melanogaster (Fruit fly) proteins of unknown function. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF07841",
"SM00718"
] | [
"DM4_12",
"DM4_12"
] | [
4768,
3330
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Arthropoda"
] | [
4770
] | 1 | [
"Drosophila melanogaster"
] | [
44
] | 1 | true | Family | Protein of unknown function DM4/12 | Protein of unknown function DM4/12 | DM4_12 | 8 |
IPR006633 | 6,633 | Carbohydrate-binding/sugar hydrolysis domain | Carb-bd_sugar_hydrolysis-dom | Domain | 10,254 | false | false | The CASH domain is shared by many carbohydrate-binding proteins and sugar hydrolases. The CASH domain is characterised by internal repetitions of glycines and hydrophobic residues that correspond to the repetitive units of a predicted or observed right-handed β-helix structure of the pectate lyase superfamily. The basi... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00722"
] | [
"CASH"
] | [
10254
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-8951664",
"R-CEL-983168",
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-8951664",
"R-MMU-983168",
"R-RNO-8951664",
"R-RNO-983168"
] | [
"REACTOME:R-CEL-8951664",
"REACTOME:R-CEL-983168",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-8951664",
"REACTOME:R-RNO-983168"
] | 8 | [
"2pyg",
"2pyh",
"4nk6",
"4nk8",
"4ozy",
"4ozz",
"5lw3",
"7o0y",
"7o10",
"7o11",
"7o12",
"7o13",
"7o14",
"7o15",
"7o16",
"7o17",
"7osf",
"7osg",
"7osh",
"7osi",
"7osj",
"7qba",
"7znq",
"8ja4",
"8ja6",
"8jaz",
"8xfq",
"8xfr"
] | 28 | [
"PUB00007977"
] | [
"11852237"
] | [
"CASH--a beta-helix domain widespread among carbohydrate-binding proteins."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Ectocarpus siliculosus virus 1 (isolate New Zealand/Kaikoura/1988)",
"Eukaryota",
"unclassified sequences"
] | [
828,
5284,
1,
4041,
100
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
7,
2,
10,
7,
13
] | 7 | true | Domain | Carbohydrate-binding/sugar hydrolysis domain | Carbohydrate-binding/sugar hydrolysis domain | Carb-bd_sugar_hydrolysis-dom | 1 |
IPR006634 | 6,634 | TRAM/LAG1/CLN8 homology domain | TLC-dom | Domain | 38,533 | false | false | TLC is a protein domain with at least 5 transmembrane α-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis [ ], TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. Proteins containing this domain may possess multiple functions such as lipid traff... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF03798",
"PS50922",
"SM00724"
] | [
"TRAM_LAG1_CLN8",
"TLC",
"TLC"
] | [
37778,
35569,
35022
] | 3 | [
"GP",
"GP",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp1423",
"GenProp1671",
"PDOC50922",
"R-BTA-1660661",
"R-CEL-1660661",
"R-HSA-1660661",
"R-HSA-1799339",
"R-MMU-1660661",
"R-SCE-1660661",
"R-SPO-1660661"
] | [
"GP:GenProp1423",
"GP:GenProp1671",
"PROSITEDOC:PDOC50922",
"REACTOME:R-BTA-1660661",
"REACTOME:R-CEL-1660661",
"REACTOME:R-HSA-1660661",
"REACTOME:R-HSA-1799339",
"REACTOME:R-MMU-1660661",
"REACTOME:R-SCE-1660661",
"REACTOME:R-SPO-1660661"
] | 10 | [
"8izd",
"8izf",
"8qtn",
"8qtr",
"8qz6",
"8qz7",
"8y2m",
"8y2n",
"8zb1",
"9eot"
] | 10 | [
"PUB00008436",
"PUB00009697"
] | [
"9872981",
"11694577"
] | [
"Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.",
"Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae."
] | [
1998,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nanobsidianus stetteri",
"Viruses",
"metagenomes"
] | [
35,
38403,
1,
50,
44
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
70,
14,
128,
4,
57,
42,
3,
33,
55,
4,
3,
101
] | 12 | true | Domain | TRAM/LAG1/CLN8 homology domain | TRAM/LAG1/CLN8 homology domain | TLC-dom | 5 |
IPR006635 | 6,635 | NEAT domain | NEAT_dom | Domain | 2,924 | false | false | This domain identifies a group of iron-regulated surface determinant proteins found exclusively in bacteria. Among them, the iron-regulated surface determinant protein H (isdH, also known as harA) binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. It binds haptoglobin-hemoglobin complexes ... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART",
"CDD"
] | [
"PF05031",
"PS50978",
"SM00725",
"cd06920"
] | [
"NEAT",
"NEAT",
"NEAT",
"NEAT"
] | [
2659,
2823,
2508,
2656
] | 4 | [
"GP",
"PROSITEDOC"
] | [
"GenProp0828",
"PDOC50978"
] | [
"GP:GenProp0828",
"PROSITEDOC:PDOC50978"
] | 2 | [
"2e7d",
"2h3k",
"2ite",
"2itf",
"2k78",
"2moq",
"2o1a",
"2o6p",
"2z6f",
"3ovu",
"3qug",
"3quh",
"3qzl",
"3qzm",
"3qzn",
"3qzo",
"3qzp",
"3rtl",
"3rur",
"3s48",
"3sik",
"3sz6",
"3szk",
"3vtm",
"3vua",
"4fc3",
"4h8p",
"4h8q",
"4ij2",
"4myp",
"4nla",
"4wjg"... | 51 | [
"PUB00043982",
"PUB00062375",
"PUB00062376"
] | [
"16762363",
"12823809",
"18984582"
] | [
"Solution structure of the NEAT (NEAr Transporter) domain from IsdH/HarA: the human hemoglobin receptor in Staphylococcus aureus.",
"Identification of a novel iron regulated staphylococcal surface protein with haptoglobin-haemoglobin binding activity.",
"Functionally distinct NEAT (NEAr Transporter) domains wit... | [
2006,
2003,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5,
2889,
22,
8
] | 4 | [] | [] | 0 | true | Domain | NEAT domain | NEAT domain | NEAT_dom | 6 |
IPR006636 | 6,636 | Heat shock chaperonin-binding | STI1_HS-bd | Domain | 23,295 | false | false | This entry represents a heat shock chaperonin-binding domain found in human Stress-inducible phosphoprotein STI1 and similar sequences found in eukaryotes. STI1 acts as a co-chaperone for HSP90AA1 [ ]. Both N- and C-terminal ends of STI1 are capable of binding heat shock proteins [ ]. This domain is found both singly a... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00727"
] | [
"STI1"
] | [
23295
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-3371497",
"R-BTA-532668",
"R-BTA-5689877",
"R-BTA-5696394",
"R-BTA-5696395",
"R-BTA-9696273",
"R-CEL-3371497",
"R-CEL-8856825",
"R-DDI-3371497",
"R-DDI-5696394",
"R-DDI-5696395",
"R-DDI-8856825",
"R-HSA-3371453",
"R-HSA-3371497",
"R-HSA-532668",
"R-HSA-5689877",
"R-HSA-5696394... | [
"REACTOME:R-BTA-3371497",
"REACTOME:R-BTA-532668",
"REACTOME:R-BTA-5689877",
"REACTOME:R-BTA-5696394",
"REACTOME:R-BTA-5696395",
"REACTOME:R-BTA-9696273",
"REACTOME:R-CEL-3371497",
"REACTOME:R-CEL-8856825",
"REACTOME:R-DDI-3371497",
"REACTOME:R-DDI-5696394",
"REACTOME:R-DDI-5696395",
"REACTOME... | 48 | [
"1oqy",
"1pve",
"1qze",
"1tp4",
"1x3w",
"1x3z",
"2f4m",
"2f4o",
"2llv",
"2llw",
"2lnm",
"2qsf",
"2qsg",
"2qsh",
"4yir",
"6cfi",
"6ubf",
"6uin",
"6xqj",
"7kw7",
"8ebs",
"8ebv",
"8ebw",
"9vfe",
"9vff",
"9vfg"
] | 26 | [
"PUB00007978",
"PUB00101128",
"PUB00103879"
] | [
"8999875",
"27353360",
"34937942"
] | [
"Stress-inducible, murine protein mSTI1. Characterization of binding domains for heat shock proteins and in vitro phosphorylation by different kinases.",
"The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.",
"Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mec... | [
1997,
2016,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"bird metagenome"
] | [
2,
38,
23254,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
49,
5,
18,
9,
35,
30,
3,
30,
35,
3,
3,
101
] | 12 | true | Domain | Heat shock chaperonin-binding | Heat shock chaperonin-binding | STI1_HS-bd | 2 |
IPR006637 | 6,637 | Clostridial hydrophobic repeat | ChW | Repeat | 1,722 | false | false | This hydrophobic repeat is found in a number of proteins from Clostridium and other bacteria. It contains a conserved tryptophan residue. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF07538",
"SM00728"
] | [
"ChW",
"ChW"
] | [
1686,
1502
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
4,
1690,
20,
3,
5
] | 5 | [] | [] | 0 | true | Repeat | Clostridial hydrophobic repeat | Clostridial hydrophobic repeat | ChW | 3 |
IPR006638 | 6,638 | Elp3/MiaA/NifB-like, radical SAM core domain | Elp3/MiaA/NifB-like_rSAM | Domain | 284,628 | false | false | This domain is found in FeMo cofactor biosynthesis protein NifB, PqqA peptide cyclase, Oxygen-independent coproporphyrinogen III oxidase (HemN), biotin synthase (BioB), Lipoyl synthase (LipA), Ribosomal protein S12 methylthiotransferase RimO, GTP 3',8-cyclase (MoaA) and tRNA-2-methylthio-N(6)-dimethylallyladenosine syn... | [
"GO:0003824",
"GO:0051536"
] | [
"catalytic activity",
"iron-sulfur cluster binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"SMART"
] | [
"SM00729"
] | [
"Elp3"
] | [
284628
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-947581",
"R-BTA-9857492",
"R-DDI-947581",
"R-DME-947581",
"R-DME-9857492",
"R-DRE-9857492",
"R-HSA-3214847",
"R-HSA-6782315",
"R-HSA-909733",
"R-HSA-947581",
"R-HSA-9857492",
"R-MMU-947581",
"R-MMU-9857492",
"R-RNO-9857492"
] | [
"REACTOME:R-BTA-947581",
"REACTOME:R-BTA-9857492",
"REACTOME:R-DDI-947581",
"REACTOME:R-DME-947581",
"REACTOME:R-DME-9857492",
"REACTOME:R-DRE-9857492",
"REACTOME:R-HSA-3214847",
"REACTOME:R-HSA-6782315",
"REACTOME:R-HSA-909733",
"REACTOME:R-HSA-947581",
"REACTOME:R-HSA-9857492",
"REACTOME:R-M... | 14 | [
"1olt",
"1r30",
"1tv7",
"1tv8",
"2fb2",
"2fb3",
"2qgq",
"3ciw",
"3cix",
"3iix",
"3iiz",
"3t7v",
"4jc0",
"4jxc",
"4jy8",
"4jy9",
"4jyd",
"4jye",
"4jyf",
"4u0o",
"4u0p",
"4wcx",
"5exi",
"5exj",
"5exk",
"5fep",
"5fes",
"5few",
"5fex",
"5fez",
"5ff0",
"5ff2"... | 102 | [
"PUB00010539",
"PUB00101370"
] | [
"11222759",
"24476342"
] | [
"Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods.",
"Radical S-adenosylmethionine enzymes."
] | [
2001,
2014
] | 2 | [
"IPR007197"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
11591,
241823,
26087,
48,
5079
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
33,
7,
14,
5,
9,
21,
10,
4,
29,
28,
3,
3,
56
] | 13 | true | Domain | Elp3/MiaA/NifB-like, radical SAM core domain | Elp3/MiaA/NifB-like, radical SAM core domain | Elp3/MiaA/NifB-like_rSAM | 8 |
IPR006639 | 6,639 | Presenilin/signal peptide peptidase | Preselin/SPP | Family | 19,632 | false | false | Presenilin 1 (PSN1) and presenilin 2 (PSN2) are membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. They undergo tightly regulated endolytic processing to generate stable PSN C-terminal and N-terminal fragments that form the catalytic core of the gamma-secretase complex, an endoprot... | [
"GO:0042500",
"GO:0016020"
] | [
"aspartic endopeptidase activity, intramembrane cleaving",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"SMART"
] | [
"SM00730"
] | [
"PSN"
] | [
19632
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.23.-",
"R-BTA-1251985",
"R-BTA-193692",
"R-BTA-205043",
"R-BTA-3928665",
"R-BTA-6798695",
"R-BTA-9839383",
"R-CEL-1251985",
"R-CEL-3928665",
"R-DDI-6798695",
"R-DME-1251985",
"R-DME-3928665",
"R-DRE-1251985",
"R-DRE-193692",
"R-DRE-3928665",
"R-DRE-6798695",
"R-DRE-9839383",
"... | [
"EC:3.4.23.-",
"REACTOME:R-BTA-1251985",
"REACTOME:R-BTA-193692",
"REACTOME:R-BTA-205043",
"REACTOME:R-BTA-3928665",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-9839383",
"REACTOME:R-CEL-1251985",
"REACTOME:R-CEL-3928665",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DME-1251985",
"REACTOME:R-DME-39286... | 64 | [
"2kr6",
"4hyc",
"4hyd",
"4hyg",
"4y6k",
"5a63",
"5fn2",
"5fn3",
"5fn4",
"5fn5",
"6idf",
"6iyc",
"6lqg",
"6lr4",
"7c9i",
"7d8x",
"7y5t",
"7y5x",
"7y5z",
"8im7",
"8k8e",
"8kco",
"8kcp",
"8kcs",
"8kct",
"8kcu",
"8oqy",
"8oqz",
"8x52",
"8x53",
"8x54",
"9k92"... | 34 | [
"PUB00020020",
"PUB00066713",
"PUB00066714"
] | [
"12077416",
"20482315",
"22593157"
] | [
"Identification of signal peptide peptidase, a presenilin-type aspartic protease.",
"Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases.",
"Structural analysis of hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal... | [
2002,
2010,
2012
] | 3 | [] | [
"IPR001108",
"IPR007369",
"IPR010545"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviridae environmental sample",
"ecological metagenomes"
] | [
548,
36,
19032,
1,
15
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
40,
7,
22,
10,
59,
21,
1,
19,
28,
1,
1,
61
] | 12 | true | Family | Presenilin/signal peptide peptidase | Presenilin/signal peptide peptidase | Preselin/SPP | 6 |
IPR006640 | 6,640 | SprT-like | SprT-like_domain | Domain | 17,692 | false | false | This entry represents a domain found in SprT ( ), which is a regulator of bolA gene in stationary phase [ ]. The majority of members contain the metallopeptidase zinc binding signature which has a HExxH motif, however there is no evidence for them being metallopeptidases. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF10263",
"SM00731"
] | [
"SprT-like",
"SprT"
] | [
17658,
13199
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-110320",
"R-CEL-110320",
"R-DRE-110320",
"R-HSA-110320",
"R-MMU-110320",
"R-RNO-110320",
"R-XTR-110320"
] | [
"REACTOME:R-BTA-110320",
"REACTOME:R-CEL-110320",
"REACTOME:R-DRE-110320",
"REACTOME:R-HSA-110320",
"REACTOME:R-MMU-110320",
"REACTOME:R-RNO-110320",
"REACTOME:R-XTR-110320"
] | 7 | [
"6mdw",
"6mdx"
] | 2 | [
"PUB00016653",
"PUB00100398"
] | [
"13129938",
"30914427"
] | [
"Experimental determination and system level analysis of essential genes in Escherichia coli MG1655.",
"SUMOylation promotes protective responses to DNA-protein crosslinks."
] | [
2003,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Plasmid pKM101",
"Viruses",
"metagenomes"
] | [
259,
10452,
6413,
1,
456,
111
] | 6 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces po... | [
2,
6,
14,
1,
4,
1,
2,
4,
3,
1,
6
] | 11 | true | Domain | SprT-like | SprT-like | SprT-like_domain | 2 |
IPR006641 | 6,641 | YqgF/RNase H-like domain | YqgF/RNaseH-like_dom | Domain | 50,219 | false | false | The YqgF domain family is described as RNase H-like and typified by the Escherichia coli protein YqgF [ ].YqgF domain-containing proteins are predicted to be ribonucleases or resolvases based on homology to RuvC Holliday junction resolvases. The group of proteins containing this domain are found primarily in the low-GC... | [
"GO:0006139"
] | [
"nucleobase-containing compound metabolic process"
] | [
"biological_process"
] | 1 | [
"SMART"
] | [
"SM00732"
] | [
"YqgFc"
] | [
50219
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-112382",
"R-CEL-674695",
"R-CEL-75955",
"R-DME-112382",
"R-DME-674695",
"R-DME-75955",
"R-HSA-112382",
"R-HSA-674695",
"R-HSA-75955",
"R-MMU-112382",
"R-MMU-674695",
"R-MMU-75955"
] | [
"REACTOME:R-CEL-112382",
"REACTOME:R-CEL-674695",
"REACTOME:R-CEL-75955",
"REACTOME:R-DME-112382",
"REACTOME:R-DME-674695",
"REACTOME:R-DME-75955",
"REACTOME:R-HSA-112382",
"REACTOME:R-HSA-674695",
"REACTOME:R-HSA-75955",
"REACTOME:R-MMU-112382",
"REACTOME:R-MMU-674695",
"REACTOME:R-MMU-75955"... | 12 | [
"1iv0",
"1nmn",
"1nu0",
"1ovq",
"1vhx",
"2oce",
"3bzc",
"3bzk",
"3psf",
"3psi",
"6gmh",
"6ted",
"7ess",
"7o3d",
"7o6b",
"7oop",
"7opc",
"7opd",
"7unc",
"7und",
"7w89",
"8a3y",
"8oeu",
"8oev",
"8of0",
"8xrm",
"9egx",
"9egy",
"9egz",
"9eh0",
"9eh1",
"9eh2"... | 39 | [
"PUB00009701",
"PUB00015164",
"PUB00015179",
"PUB00044514",
"PUB00050835"
] | [
"10982859",
"8648624",
"12934008",
"8755871",
"18321528"
] | [
"SURVEY AND SUMMARY: holliday junction resolvases and related nucleases: identification of new families, phyletic distribution and evolutionary trajectories.",
"Holliday junction resolvases encoded by homologous rusA genes in Escherichia coli K-12 and phage 82.",
"Transcription elongation factors repress transc... | [
2000,
1996,
2003,
1996,
2008
] | 5 | [] | [
"IPR028231",
"IPR032639"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
66,
43739,
5762,
652
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (s... | [
19,
2,
9,
4,
2,
5,
3,
6,
10,
1,
1,
22
] | 12 | true | Domain | YqgF/RNase H-like domain | YqgF/RNase H-like domain | YqgF/RNaseH-like_dom | 8 |
IPR006642 | 6,642 | Rad18, zinc finger UBZ4-type | Rad18_UBZ4 | Domain | 12,434 | false | false | The ubiquitin-binding zinc finger (UBZ) is a type of zinc-coordinating β-β-α fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several ... | [
"GO:0003677",
"GO:0006281"
] | [
"DNA binding",
"DNA repair"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROFILE",
"SMART"
] | [
"PS51908",
"SM00734"
] | [
"ZF_UBZ4",
"ZnF_Rad18"
] | [
8553,
10646
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-110320",
"R-CEL-110320",
"R-CEL-5655862",
"R-CEL-5696397",
"R-CEL-5696400",
"R-CEL-6782135",
"R-CEL-6782210",
"R-DRE-110320",
"R-GGA-353248",
"R-GGA-353303",
"R-HSA-110314",
"R-HSA-110320",
"R-HSA-5655862",
"R-HSA-5656169",
"R-HSA-5685942",
"R-HSA-5689901",
"R-HSA-5693565",
... | [
"REACTOME:R-BTA-110320",
"REACTOME:R-CEL-110320",
"REACTOME:R-CEL-5655862",
"REACTOME:R-CEL-5696397",
"REACTOME:R-CEL-5696400",
"REACTOME:R-CEL-6782135",
"REACTOME:R-CEL-6782210",
"REACTOME:R-DRE-110320",
"REACTOME:R-GGA-353248",
"REACTOME:R-GGA-353303",
"REACTOME:R-HSA-110314",
"REACTOME:R-HS... | 60 | [
"2mre",
"2mrf",
"3vhs",
"3vht",
"5vf0",
"7nv0",
"7nv1",
"9gy0"
] | 8 | [
"PUB00009702",
"PUB00035841",
"PUB00041615",
"PUB00091153",
"PUB00091660",
"PUB00094758",
"PUB00094760",
"PUB00094761",
"PUB00094762",
"PUB00094763",
"PUB00094764",
"PUB00094765",
"PUB00094766",
"PUB00094767",
"PUB00094768"
] | [
"2970061",
"16980296",
"17304240",
"27062441",
"26506893",
"25414354",
"25162118",
"19213613",
"17550419",
"24239949",
"20837403",
"25799058",
"20385554",
"27370208",
"24794496"
] | [
"The Saccharomyces cerevisiae RAD18 gene encodes a protein that contains potential zinc finger domains for nucleic acid binding and a putative nucleotide binding sequence.",
"Replication-dependent and -independent responses of RAD18 to DNA damage in human cells.",
"Structure of the ubiquitin-binding zinc finger... | [
1988,
2006,
2007,
2016,
2015,
2014,
2014,
2009,
2007,
2014,
2010,
2015,
2010,
2016,
2014
] | 15 | [] | [
"IPR040539"
] | 0 | 1 | 0 | [
"Erysiphe necator associated hypovirus 1",
"Eukaryota"
] | [
1,
12433
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
... | [
3,
16,
4,
19,
26,
3,
3,
34,
3,
4,
11
] | 11 | true | Domain | Rad18, zinc finger UBZ4-type | Rad18, zinc finger UBZ4-type | Rad18_UBZ4 | 5 |
IPR006644 | 6,644 | Dystroglycan-type cadherin-like | Cadg | Domain | 11,981 | false | false | In animals, cadherin domain-containing proteins are adhesion molecules that modulate a wide variety of processes including cell polarization and migration but they have also been identified in yeast and magnetotactic bacteria. Crystal structures have revealed that multiple cadherin domains form Ca 2+ -dependent rod-lik... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"SMART"
] | [
"SM00736"
] | [
"CADG"
] | [
11981
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CFA-8932504",
"R-CFA-8932505",
"R-CFA-8932506",
"R-CFA-9010553",
"R-CFA-9913351",
"R-CFA-9939291",
"R-HSA-3000171",
"R-HSA-3000178",
"R-HSA-5083628",
"R-HSA-5083629",
"R-HSA-5083633",
"R-HSA-8932504",
"R-HSA-8932505",
"R-HSA-8932506",
"R-HSA-9010553",
"R-HSA-9619665",
"R-HSA-99133... | [
"REACTOME:R-CFA-8932504",
"REACTOME:R-CFA-8932505",
"REACTOME:R-CFA-8932506",
"REACTOME:R-CFA-9010553",
"REACTOME:R-CFA-9913351",
"REACTOME:R-CFA-9939291",
"REACTOME:R-HSA-3000171",
"REACTOME:R-HSA-3000178",
"REACTOME:R-HSA-5083628",
"REACTOME:R-HSA-5083629",
"REACTOME:R-HSA-5083633",
"REACTOM... | 25 | [
"1u2c",
"4wiq",
"5llk",
"5n30",
"5n4h",
"8uf4",
"8yt8",
"9c3c"
] | 8 | [
"PUB00009704"
] | [
"11909544"
] | [
"Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteins."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Pithovirus LCPAC404",
"unclassified sequences"
] | [
76,
5319,
6483,
1,
102
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2,
11,
10,
54,
16,
1,
13,
1
] | 8 | true | Domain | Dystroglycan-type cadherin-like | Dystroglycan-type cadherin-like | Cadg | 2 |
IPR006645 | 6,645 | NusG-like, N-terminal | NGN-like_dom | Domain | 38,696 | false | false | This is the N-terminal domain of transcription termination/antitermination protein NusG, which is involved in transcription elongation, termination and antitermination. It also occurs at the N-terminal of transcription antitermination protein RfaH and in the transcription elongation factor Spt5 [ , , , ]. | [
"GO:0006354"
] | [
"DNA-templated transcription elongation"
] | [
"biological_process"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF02357",
"SM00738"
] | [
"NusG",
"NGN"
] | [
33730,
34620
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-112382",
"R-CEL-113418",
"R-CEL-674695",
"R-CEL-6796648",
"R-CEL-72086",
"R-CEL-75955",
"R-CEL-77075",
"R-DME-112382",
"R-DME-113418",
"R-DME-674695",
"R-DME-6796648",
"R-DME-6807505",
"R-DME-72086",
"R-DME-75955",
"R-DME-77075",
"R-DRE-674695",
"R-DRE-6796648",
"R-DRE-72086... | [
"REACTOME:R-CEL-112382",
"REACTOME:R-CEL-113418",
"REACTOME:R-CEL-674695",
"REACTOME:R-CEL-6796648",
"REACTOME:R-CEL-72086",
"REACTOME:R-CEL-75955",
"REACTOME:R-CEL-77075",
"REACTOME:R-DME-112382",
"REACTOME:R-DME-113418",
"REACTOME:R-DME-674695",
"REACTOME:R-DME-6796648",
"REACTOME:R-DME-6807... | 55 | [
"1m1g",
"1m1h",
"1npp",
"1npr",
"1nz8",
"2exu",
"2jvv",
"2k06",
"2lq8",
"2oug",
"2xhc",
"3ewg",
"3h7h",
"3lpe",
"3p8b",
"3qqc",
"4zn1",
"4zn3",
"5ms0",
"5oik",
"5ond",
"5tbz",
"6c6s",
"6c6t",
"6c6u",
"6gmh",
"6gml",
"6gov",
"6ted",
"6tqn",
"6tqo",
"6vu3"... | 182 | [
"PUB00053827",
"PUB00092162",
"PUB00100966",
"PUB00100967"
] | [
"19000817",
"22982195",
"33488562",
"33835023"
] | [
"Core structure of the yeast spt4-spt5 complex: a conserved module for regulation of transcription elongation.",
"The Spt4-Spt5 complex: a multi-faceted regulator of transcription elongation.",
"NusG, an Ancient Yet Rapidly Evolving Transcription Factor.",
"NusG is an intrinsic transcription termination facto... | [
2008,
2013,
2020,
2021
] | 4 | [] | [
"IPR047050"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Plasmid R64",
"Viruses",
"unclassified sequences"
] | [
853,
32678,
4495,
1,
13,
656
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
12,
1,
5,
1,
2,
3,
2,
1,
7,
5,
1,
1,
28
] | 13 | true | Domain | NusG-like, N-terminal | NusG-like, N-terminal | NGN-like_dom | 4 |
IPR006650 | 6,650 | Adenosine/AMP deaminase active site | A/AMP_deam_AS | Active_site | 17,588 | false | false | Adenosine deaminase ( ) catalyzes the hydrolytic deamination of adenosine into inosine and AMP deaminase ( ) catalyzes the hydrolytic deamination of AMP into IMP. It has been shown [ ] that these two enzymes share three regions of sequence similarities; these regions are centred on residues which are proposed to play a... | [
"GO:0019239",
"GO:0009168"
] | [
"deaminase activity",
"purine ribonucleoside monophosphate biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS00485"
] | [
"A_DEAMINASE"
] | [
17588
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTO... | [
"3.5.4",
"3.5.4.4",
"PWY-6609",
"PWY-6611",
"PWY-7179",
"PDOC00419",
"R-DDI-6798695",
"R-DDI-74217",
"R-DRE-74217",
"R-DRE-9755088",
"R-HSA-6798695",
"R-HSA-74217",
"R-HSA-9734735",
"R-HSA-9755088",
"R-MMU-6798695",
"R-MMU-74217",
"R-MMU-9755088",
"R-PFA-74217",
"R-PFA-9755088",
... | [
"EC:3.5.4",
"EC:3.5.4.4",
"METACYC:PWY-6609",
"METACYC:PWY-6611",
"METACYC:PWY-7179",
"PROSITEDOC:PDOC00419",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-74217",
"REACTOME:R-DRE-74217",
"REACTOME:R-DRE-9755088",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-74217",
"REACTOME:R-HSA-9734735",
"REA... | 28 | [
"1a4l",
"1a4m",
"1add",
"1krm",
"1ndv",
"1ndw",
"1ndy",
"1ndz",
"1o5r",
"1qxl",
"1uio",
"1uip",
"1uml",
"1v79",
"1v7a",
"1vfl",
"1w1i",
"1wxy",
"1wxz",
"2a3l",
"2ada",
"2amx",
"2bgn",
"2e1w",
"2pgf",
"2pgr",
"2qvn",
"2z7g",
"3ewc",
"3ewd",
"3iar",
"3km8"... | 39 | [
"PUB00000343"
] | [
"1998686"
] | [
"Deduced amino acid sequence of Escherichia coli adenosine deaminase reveals evolutionarily conserved amino acid residues: implications for catalytic function."
] | [
1991
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3,
4020,
13545,
20
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
2,
4,
34,
9,
1,
37,
10,
1,
3,
24,
2,
1,
14
] | 13 | true | Active_site | Adenosine/AMP deaminase active site | Adenosine/AMP deaminase active site | A/AMP_deam_AS | 5 |
IPR006652 | 6,652 | Kelch repeat type 1 | Kelch_1 | Repeat | 126,663 | false | false | This entry represents a type of kelch sequence motif that comprises one β-sheet blade. Kelch is a 50-residue motif, named after the Drosophila mutant in which it was first identified [ ]. This sequence motif represents one β-sheet blade, and several of these repeats can associate to form a β-propeller. For instance, th... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF01344",
"SM00612"
] | [
"Kelch_1",
"Kelch"
] | [
89389,
114051
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-8951664",
"R-BTA-983168",
"R-DDI-193648",
"R-DDI-4641258",
"R-DDI-5658442",
"R-DDI-8951664",
"R-DDI-9013148",
"R-DDI-9013149",
"R-DDI-9755511",
"R-DDI-983168",
"R-DME-8951664",
"R-DME-983168",
"R-DRE-4641258",
"R-DRE-5689880",
"R-DRE-8951664",
"R-DRE-9755511",
"R-DRE-983168",
... | [
"REACTOME:R-BTA-8951664",
"REACTOME:R-BTA-983168",
"REACTOME:R-DDI-193648",
"REACTOME:R-DDI-4641258",
"REACTOME:R-DDI-5658442",
"REACTOME:R-DDI-8951664",
"REACTOME:R-DDI-9013148",
"REACTOME:R-DDI-9013149",
"REACTOME:R-DDI-9755511",
"REACTOME:R-DDI-983168",
"REACTOME:R-DME-8951664",
"REACTOME:R... | 47 | [
"1gof",
"1gog",
"1goh",
"1k3i",
"1t2x",
"1u6d",
"1x2j",
"1x2r",
"1zgk",
"2dyh",
"2eib",
"2eic",
"2eid",
"2eie",
"2flu",
"2jkx",
"2vpj",
"2vz1",
"2vz3",
"2woz",
"2wq8",
"2xn4",
"2z32",
"2zw9",
"2zwa",
"2zzk",
"3ade",
"3ii7",
"3vng",
"3vnh",
"3wdz",
"3wn7"... | 258 | [
"PUB00000885",
"PUB00003079",
"PUB00003094",
"PUB00003318",
"PUB00003324",
"PUB00004093"
] | [
"8453663",
"7822422",
"7593276",
"8126718",
"8182749",
"2002850"
] | [
"kelch encodes a component of intercellular bridges in Drosophila egg chambers.",
"Sequence and domain organization of scruin, an actin-cross-linking protein in the acrosomal process of Limulus sperm.",
"beta-Scruin, a homologue of the actin crosslinking protein scruin, is localized to the acrosomal vesicle of ... | [
1993,
1995,
1995,
1994,
1994,
1991
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
86,
6659,
119149,
631,
138
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
316,
19,
181,
31,
190,
140,
4,
113,
196,
1,
2,
183
] | 12 | true | Repeat | Kelch repeat type 1 | Kelch repeat type 1 | Kelch_1 | 6 |
IPR006653 | 6,653 | Tryptophan synthase, beta chain, conserved site | Trp_synth_b_CS | Conserved_site | 31,851 | false | false | Tryptophan synthase catalyses the last step in the biosynthesis of tryptophan [ , ]: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H 2 O It has two functional domains, each found in bacteria and plants on a separate subunit: alpha chain ( ) is for the aldol cleavage of indo... | [
"GO:0004834",
"GO:0006568"
] | [
"tryptophan synthase activity",
"L-tryptophan metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS00168"
] | [
"TRP_SYNTHASE_BETA"
] | [
31851
] | 1 | [
"EC",
"PROSITEDOC"
] | [
"4.2.1.20",
"PDOC00152"
] | [
"EC:4.2.1.20",
"PROSITEDOC:PDOC00152"
] | 2 | [
"1a50",
"1a5a",
"1a5b",
"1a5s",
"1beu",
"1bks",
"1c29",
"1c8v",
"1c9d",
"1cw2",
"1cx9",
"1fuy",
"1k3u",
"1k7e",
"1k7f",
"1k7x",
"1k8x",
"1k8y",
"1k8z",
"1kfb",
"1kfc",
"1kfe",
"1kfj",
"1kfk",
"1qop",
"1qoq",
"1tjp",
"1ttp",
"1ttq",
"1v8z",
"1wbj",
"1wdw"... | 178 | [
"PUB00000116",
"PUB00000769",
"PUB00004683"
] | [
"2679363",
"1366510",
"2734310"
] | [
"Evolution of a biosynthetic pathway: the tryptophan paradigm.",
"The tryptophan synthase multienzyme complex: exploring structure-function relationships with X-ray crystallography and mutagenesis.",
"A gene encoding the tryptophan synthase beta subunit of Arabidopsis thaliana."
] | [
1989,
1990,
1989
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1223,
26306,
3730,
592
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
19,
1,
1,
3,
1,
1,
7
] | 7 | true | Conserved_site | Tryptophan synthase, beta chain, conserved site | Tryptophan synthase, beta chain, conserved site | Trp_synth_b_CS | 5 |
IPR006655 | 6,655 | Molybdopterin oxidoreductase, prokaryotic, conserved site | Mopterin_OxRdtase_prok_CS | Conserved_site | 41,288 | false | false | A number of different prokaryotic oxidoreductases that require and bind a molybdopterin cofactor have been shown [ , , ] to share a number of regions of sequence similarity. These enzymes are: Escherichia coli respiratory nitrate reductase (EC 1.7.99.4). This enzyme complex allows the bacteria to use nitrate as an elec... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE",
"PROSITE"
] | [
"PS00490",
"PS00932"
] | [
"MOLYBDOPTERIN_PROK_2",
"MOLYBDOPTERIN_PROK_3"
] | [
26727,
25716
] | 2 | [
"PROSITEDOC"
] | [
"PDOC00392"
] | [
"PROSITEDOC:PDOC00392"
] | 1 | [
"1aa6",
"1dmr",
"1dms",
"1e18",
"1e5v",
"1e60",
"1e61",
"1eu1",
"1fdi",
"1fdo",
"1h0h",
"1h5n",
"1kqf",
"1kqg",
"1q16",
"1r27",
"1siw",
"1tmo",
"1y4z",
"1y5i",
"1y5l",
"1y5n",
"2dmr",
"2iv2",
"3dmr",
"3egw",
"3ir5",
"3ir6",
"3ir7",
"4dmr",
"6sdr",
"6sdv"... | 67 | [
"PUB00000608",
"PUB00002890",
"PUB00003788",
"PUB00003854"
] | [
"2015248",
"8125918",
"3062312",
"8022286"
] | [
"Enzymes depending on the pterin molybdenum cofactor: sequence families, spectroscopic properties of molybdenum and possible cofactor-binding domains.",
"Multiple pathways of electron transfer in dimethyl sulfoxide reductase of Escherichia coli.",
"Nucleotide sequence of the dmsABC operon encoding the anaerobic... | [
1991,
1994,
1988,
1994
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Escherichia phage RCS47",
"Eukaryota",
"unclassified sequences"
] | [
1015,
39754,
1,
39,
479
] | 5 | [
"Escherichia coli (strain K12)"
] | [
11
] | 1 | true | Conserved_site | Molybdopterin oxidoreductase, prokaryotic, conserved site | Molybdopterin oxidoreductase, prokaryotic, conserved site | Mopterin_OxRdtase_prok_CS | 3 |
IPR006656 | 6,656 | Molybdopterin oxidoreductase | Mopterin_OxRdtase | Domain | 122,047 | false | false | This domain is found in a number of molybdopterin-containing oxidoreductases, tungsten formylmethanofuran dehydrogenase subunit d (FwdD), and molybdenum formylmethanofuran dehydrogenase subunit (FmdD); where a single domain constitutes almost the entire subunit. This domain is also found in periplasmic nitrate reductas... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00384"
] | [
"Molybdopterin"
] | [
122047
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-611105",
"R-BTA-6799198",
"R-BTA-9837999",
"R-DDI-6799198",
"R-DDI-9837999",
"R-DME-611105",
"R-DME-6799198",
"R-DME-9837999",
"R-HSA-611105",
"R-HSA-6799198",
"R-HSA-9837999",
"R-MMU-611105",
"R-MMU-6799198",
"R-MMU-9837999",
"R-RNO-611105",
"R-RNO-6799198",
"R-RNO-9837999"
] | [
"REACTOME:R-BTA-611105",
"REACTOME:R-BTA-6799198",
"REACTOME:R-BTA-9837999",
"REACTOME:R-DDI-6799198",
"REACTOME:R-DDI-9837999",
"REACTOME:R-DME-611105",
"REACTOME:R-DME-6799198",
"REACTOME:R-DME-9837999",
"REACTOME:R-HSA-611105",
"REACTOME:R-HSA-6799198",
"REACTOME:R-HSA-9837999",
"REACTOME:R... | 17 | [
"1aa6",
"1dmr",
"1dms",
"1e18",
"1e5v",
"1e60",
"1e61",
"1eu1",
"1fdi",
"1fdo",
"1g8j",
"1g8k",
"1h0h",
"1h5n",
"1kqf",
"1kqg",
"1ogy",
"1q16",
"1r27",
"1siw",
"1tmo",
"1y4z",
"1y5i",
"1y5l",
"1y5n",
"2dmr",
"2e7z",
"2fug",
"2iv2",
"2ivf",
"2jim",
"2jio"... | 431 | [
"PUB00000170"
] | [
"9818358"
] | [
"The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium wolfei and Methanobacterium thermoautotrophicum: induction of the molybdenum isoenzyme by molybdate and constitutive synthesis of the tungsten isoenzyme."
] | [
1998
] | 1 | [] | [
"IPR041932"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Escherichia phage RCS47",
"Eukaryota",
"unclassified sequences"
] | [
2694,
110621,
1,
5480,
3251
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
7,
1,
1,
4,
14,
5,
4,
1,
4,
4,
10
] | 11 | true | Domain | Molybdopterin oxidoreductase | Molybdopterin oxidoreductase | Mopterin_OxRdtase | 2 |
IPR006657 | 6,657 | Molybdopterin dinucleotide-binding domain | MoPterin_dinucl-bd_dom | Domain | 98,102 | false | false | This domain is found in various molybdopterin-containing oxidoreductases, such as Molybdenum-containing formylmethanofuran dehydrogenase 1 subunit C (FmdC). The formylmethanofuran dehydrogenase catalyses the first step in methane formation from CO2 in methanogenic archaea and has a molybdopterin dinucleotide cofactor [... | [
"GO:0016491",
"GO:0043546"
] | [
"oxidoreductase activity",
"molybdopterin cofactor binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF01568"
] | [
"Molydop_binding"
] | [
98102
] | 1 | [] | [] | [] | 0 | [
"1aa6",
"1dmr",
"1dms",
"1e18",
"1e5v",
"1e60",
"1e61",
"1eu1",
"1fdi",
"1fdo",
"1g8j",
"1g8k",
"1h0h",
"1h5n",
"1kqf",
"1kqg",
"1ogy",
"1q16",
"1r27",
"1siw",
"1tmo",
"1y4z",
"1y5i",
"1y5l",
"1y5n",
"2dmr",
"2e7z",
"2fug",
"2iv2",
"2ivf",
"2jim",
"2jio"... | 165 | [
"PUB00000170",
"PUB00003373"
] | [
"9818358",
"8890912"
] | [
"The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium wolfei and Methanobacterium thermoautotrophicum: induction of the molybdenum isoenzyme by molybdate and constitutive synthesis of the tungsten isoenzyme.",
"Crystal structure of dimethyl sulfoxide reductase from Rhodobacter capsulatus at 1.88 A ... | [
1998,
1996
] | 2 | [] | [
"IPR037920",
"IPR037943",
"IPR037946",
"IPR037949",
"IPR037951",
"IPR041717",
"IPR041925",
"IPR041954",
"IPR041957"
] | 0 | 9 | 0 | [
"Archaea",
"Bacteria",
"Escherichia phage RCS47",
"Eukaryota",
"unclassified sequences"
] | [
2498,
93442,
1,
333,
1828
] | 5 | [
"Escherichia coli (strain K12)"
] | [
13
] | 1 | true | Domain | Molybdopterin dinucleotide-binding domain | Molybdopterin dinucleotide-binding domain | MoPterin_dinucl-bd_dom | 9 |
IPR006658 | 6,658 | Molybdopterin guanine dinucleotide-containing S/N-oxide reductase | BisC | Family | 3,694 | false | false | This enzyme family shares sequence similarity and a requirement for a molydenum cofactor as the only prosthetic group. The form of the cofactor is a single molybdenum atom coordinated by two molybdopterin guanine dinucleotide molecules. Members of the family include biotin sulphoxide reductase, dimethylsulphoxide reduc... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00509"
] | [
"bisC_fam"
] | [
3694
] | 1 | [
"EC",
"GP",
"GP",
"GP"
] | [
"1.7.2.3",
"GenProp1341",
"GenProp1535",
"GenProp1582"
] | [
"EC:1.7.2.3",
"GP:GenProp1341",
"GP:GenProp1535",
"GP:GenProp1582"
] | 4 | [
"1dmr",
"1dms",
"1e18",
"1e5v",
"1e60",
"1e61",
"1eu1",
"1h5n",
"2dmr",
"3dmr",
"4dmr",
"7l5i",
"7l5s",
"9h4t"
] | 14 | [
"PUB00007981"
] | [
"9013576"
] | [
"Biotin sulfoxide reductase. Heterologous expression and characterization of a functional molybdopterin guanine dinucleotide-containing enzyme."
] | [
1997
] | 1 | [] | [
"IPR011887"
] | 0 | 1 | 0 | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
3687,
2,
5
] | 3 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Molybdopterin guanine dinucleotide-containing S/N-oxide reductase | Molybdopterin guanine dinucleotide-containing S/N-oxide reductase | BisC | 7 |
IPR006659 | 6,659 | Arsenate reductase | Arsenate_reductase | Family | 14,545 | false | false | This entry describes a distinct clade, including ArsC itself, of the broader family of ArsC and related proteins. This clade is almost completely restricted to the proteobacteria. An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773 [ ]. When exp... | [
"GO:0008794"
] | [
"arsenate reductase (glutaredoxin) activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM",
"CDD"
] | [
"TIGR00014",
"cd03034"
] | [
"arsC",
"ArsC_ArsC"
] | [
13012,
14351
] | 2 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.20.4.1",
"GenProp0474",
"PWY-4621",
"PWY-8259",
"PWY-8263",
"PWY-8264"
] | [
"EC:1.20.4.1",
"GP:GenProp0474",
"METACYC:PWY-4621",
"METACYC:PWY-8259",
"METACYC:PWY-8263",
"METACYC:PWY-8264"
] | 6 | [
"1i9d",
"1j9b",
"1jzw",
"1s3c",
"1s3d",
"1sd8",
"1sd9",
"1sjz",
"1sk0",
"1sk1",
"1sk2",
"2mu0",
"3f0i",
"3rdw"
] | 14 | [
"PUB00007982",
"PUB00025947",
"PUB00080836",
"PUB00080837"
] | [
"1704144",
"11709171",
"12877744",
"12426124"
] | [
"The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase.",
"Insights into the structure, solvation, and mechanism of ArsC arsenate reductase, a novel arsenic detoxification enzyme.",
"Phylogenetic analysis of bacterial and archaeal arsC gene sequences suggests an ancient, common origin for... | [
1990,
2001,
2003,
2002
] | 4 | [
"IPR006660"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
14384,
30,
130,
1
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Arsenate reductase | Arsenate reductase | Arsenate_reductase | 6 |
IPR006660 | 6,660 | Arsenate reductase-like | Arsenate_reductase-like | Family | 38,747 | false | false | Several bacterial taxon have a chromosomal resistance system, encoded by the ars operon, for the detoxification of arsenate, arsenite, and antimonite [ ]. This system transports arsenite and antimonite out of the cell. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit e... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"PANTHER"
] | [
"PF03960",
"PS51353",
"PTHR30041"
] | [
"ArsC",
"ARSC",
""
] | [
36904,
38695,
36709
] | 3 | [] | [] | [] | 0 | [
"1i9d",
"1j9b",
"1jzw",
"1rw1",
"1s3c",
"1s3d",
"1sd8",
"1sd9",
"1sjz",
"1sk0",
"1sk1",
"1sk2",
"1z3e",
"2kok",
"2m46",
"2mu0",
"3f0i",
"3fz4",
"3gfk",
"3gkx",
"3ihq",
"3l78",
"3rdw",
"6ghb",
"6gho",
"7f75"
] | 26 | [
"PUB00025947",
"PUB00043811",
"PUB00043812",
"PUB00043813",
"PUB00095599"
] | [
"11709171",
"7860609",
"9261111",
"15028674",
"29271514"
] | [
"Insights into the structure, solvation, and mechanism of ArsC arsenate reductase, a novel arsenic detoxification enzyme.",
"The ars operon of Escherichia coli confers arsenical and antimonial resistance.",
"Ligand interactions of the ArsC arsenate reductase.",
"Spx-RNA polymerase interaction and global trans... | [
2001,
1995,
1997,
2004,
2018
] | 5 | [] | [
"IPR006503",
"IPR006504",
"IPR006659"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
46,
37675,
595,
28,
403
] | 5 | [
"Escherichia coli (strain K12)",
"Zea mays"
] | [
5,
3
] | 2 | true | Family | Arsenate reductase-like | Arsenate reductase-like | Arsenate_reductase-like | 2 |
IPR006664 | 6,664 | Outer membrane protein, bacterial | OMP_bac | Domain | 77,072 | false | false | Most of the bacterial outer membrane proteins in this group are porin-like integral membrane proteins (such as ompA) [ ], but some are small lipid-anchored proteins (such as pal) [ ]. They are present in the outer membrane of many Gram-negative organisms [ ]. The C-terminal half of these proteins and is well conserved.... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PRINTS"
] | [
"PR01021"
] | [
"OMPADOMAIN"
] | [
77072
] | 1 | [] | [] | [] | 0 | [
"1oap",
"1r1m",
"2aiz",
"2hqs",
"2k1s",
"2kgw",
"2l26",
"2lbt",
"2lca",
"2mqe",
"2n48",
"2w8b",
"3nb3",
"3td3",
"3td4",
"3td5",
"4b5c",
"4erh",
"4g4v",
"4g4w",
"4g4x",
"4g4y",
"4g4z",
"4g88",
"4pwt",
"4r40",
"4rha",
"4zhv",
"4zhw",
"4zhy",
"5eaz",
"5eb0"... | 51 | [
"PUB00003748",
"PUB00006250",
"PUB00006564"
] | [
"1538702",
"2202726",
"10515919"
] | [
"Homology of the root adhesin of Pseudomonas fluorescens OE 28.3 with porin F of P. aeruginosa and P. syringae.",
"Export and sorting of the Escherichia coli outer membrane protein OmpA.",
"In vitro characterization of peptidoglycan-associated lipoprotein (PAL)-peptidoglycan and PAL-TolB interactions."
] | [
1992,
1990,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Nitrosopumilus salarius BD31",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
76210,
1,
151,
6,
704
] | 5 | [
"Escherichia coli (strain K12)"
] | [
4
] | 1 | true | Domain | Outer membrane protein, bacterial | Outer membrane protein, bacterial | OMP_bac | 6 |
IPR006665 | 6,665 | OmpA-like domain | OmpA-like | Domain | 126,211 | false | false | This entry represents a domain with a β/α/β/α-β(2) structure found in the C-terminal region of many Gram-negative bacterial outer membrane proteins [ ], such as porin-like integral membrane proteins (such as ompA) [ ], small lipid-anchored proteins (such as pal) [ ], and MotB proton channels [ ]. The N-terminal half is... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"CDD"
] | [
"PF00691",
"PS51123",
"cd07185"
] | [
"OmpA",
"OMPA_2",
"OmpA_C-like"
] | [
124051,
124516,
118160
] | 3 | [
"GP",
"PROSITEDOC"
] | [
"GenProp0877",
"PDOC00819"
] | [
"GP:GenProp0877",
"PROSITEDOC:PDOC00819"
] | 2 | [
"1oap",
"1r1m",
"2aiz",
"2hqs",
"2k1s",
"2kgw",
"2l26",
"2lbt",
"2lca",
"2mqe",
"2n48",
"2w8b",
"2zf8",
"2zov",
"2zvy",
"2zvz",
"3cyp",
"3cyq",
"3imp",
"3khn",
"3ldt",
"3nb3",
"3oon",
"3s02",
"3s03",
"3s06",
"3s0h",
"3s0w",
"3s0y",
"3td3",
"3td4",
"3td5"... | 113 | [
"PUB00002029",
"PUB00003748",
"PUB00006250",
"PUB00006564",
"PUB00018018",
"PUB00035646",
"PUB00035647",
"PUB00078825",
"PUB00078826"
] | [
"8112835",
"1538702",
"2202726",
"10515919",
"14763978",
"17368067",
"17052729",
"8636046",
"15866878"
] | [
"Identification and characterization of the Treponema pallidum tpn50 gene, an ompA homolog.",
"Homology of the root adhesin of Pseudomonas fluorescens OE 28.3 with porin F of P. aeruginosa and P. syringae.",
"Export and sorting of the Escherichia coli outer membrane protein OmpA.",
"In vitro characterization ... | [
1994,
1992,
1990,
1999,
2004,
2007,
2006,
1996,
2005
] | 9 | [] | [
"IPR014169",
"IPR017733"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
4,
124419,
372,
24,
6,
1386
] | 6 | [
"Escherichia coli (strain K12)"
] | [
6
] | 1 | true | Domain | OmpA-like domain | OmpA-like domain | OmpA-like | 9 |
IPR006667 | 6,667 | SLC41A/MgtE, integral membrane domain | SLC41_membr_dom | Domain | 28,703 | false | false | This entry represents the integral membrane region of SLC41 transporter proteins. SLC41 family of divalent cation transporters includes SLC41A1/2/3 from eukaryotes and MgtE from prokaryotes [ , , , , ]. MgtE is the prokaryote homologue of SLC41A1 magnesium transporter which adopts a homodimeric architecture with five t... | [
"GO:0008324",
"GO:0006812"
] | [
"monoatomic cation transmembrane transporter activity",
"monoatomic cation transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF01769"
] | [
"MgtE"
] | [
28703
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-425410",
"R-HSA-425410",
"R-MMU-425410"
] | [
"REACTOME:R-DRE-425410",
"REACTOME:R-HSA-425410",
"REACTOME:R-MMU-425410"
] | 3 | [
"2yvx",
"2zy9",
"4u9l",
"4u9n",
"4wib",
"5x9h",
"6lbh",
"8h5e"
] | 8 | [
"PUB00044725",
"PUB00064559",
"PUB00098696",
"PUB00098698",
"PUB00098699",
"PUB00098702",
"PUB00098704"
] | [
"17700703",
"15809054",
"12810078",
"27349617",
"33905418",
"23954807",
"23506895"
] | [
"Crystal structure of the MgtE Mg2+ transporter.",
"Functional characterization of the mouse [corrected] solute carrier, SLC41A2.",
"The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters.",
"Identification of SLC41A3 as a novel player in m... | [
2007,
2005,
2003,
2016,
2021,
2013,
2013
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ctTrm2",
"unclassified sequences"
] | [
1217,
19543,
7617,
1,
325
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
21,
6,
10,
5,
15
] | 6 | true | Domain | SLC41A/MgtE, integral membrane domain | SLC41A/MgtE, integral membrane domain | SLC41_membr_dom | 6 |
IPR006669 | 6,669 | Magnesium transporter MgtE | MgtE_transporter | Family | 24,226 | false | false | This entry represents the MgtE family of magnesium transporters. MgtE is a highly Mg2+-selective channel gated by Mg2+ [ ]. It is an SLC41A1 orthologue found in prokaryotes, which consists of a homodimer architecture with five transmembrane domains in the C terminus and cytosolic N terminus domains. Structural and func... | [
"GO:0015095",
"GO:0015693",
"GO:0016020"
] | [
"magnesium ion transmembrane transporter activity",
"magnesium ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR43773",
"TIGR00400"
] | [
"",
"mgtE"
] | [
22968,
17686
] | 2 | [] | [] | [] | 0 | [
"1vr9",
"2oux",
"2yvx",
"2yvy",
"2yvz",
"2zy9",
"5x9g",
"5x9h",
"8gps",
"8gpv"
] | 10 | [
"PUB00044725",
"PUB00070393",
"PUB00098702"
] | [
"17700703",
"19798051",
"23954807"
] | [
"Crystal structure of the MgtE Mg2+ transporter.",
"Mg(2+)-dependent gating of bacterial MgtE channel underlies Mg(2+) homeostasis.",
"The structure and regulation of magnesium selective ion channels."
] | [
2007,
2009,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ctTrm2",
"unclassified sequences"
] | [
122,
23468,
87,
1,
548
] | 5 | [] | [] | 0 | true | Family | Magnesium transporter MgtE | Magnesium transporter MgtE | MgtE_transporter | 7 |
IPR006671 | 6,671 | Cyclin, N-terminal | Cyclin_N | Domain | 91,132 | false | false | Cyclins contain two domains of similar all-α fold, of which this entry is associated with the N-terminal domain. Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [ ], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00134"
] | [
"Cyclin_N"
] | [
91132
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00264",
"R-BTA-112382",
"R-BTA-1538133",
"R-BTA-174048",
"R-BTA-176408",
"R-BTA-176412",
"R-BTA-176417",
"R-BTA-187577",
"R-BTA-212436",
"R-BTA-2173796",
"R-BTA-2299718",
"R-BTA-2500257",
"R-BTA-2559586",
"R-BTA-2565942",
"R-BTA-2980767",
"R-BTA-2995383",
"R-BTA-3301854",
"R-B... | [
"PROSITEDOC:PDOC00264",
"REACTOME:R-BTA-112382",
"REACTOME:R-BTA-1538133",
"REACTOME:R-BTA-174048",
"REACTOME:R-BTA-176408",
"REACTOME:R-BTA-176412",
"REACTOME:R-BTA-176417",
"REACTOME:R-BTA-187577",
"REACTOME:R-BTA-212436",
"REACTOME:R-BTA-2173796",
"REACTOME:R-BTA-2299718",
"REACTOME:R-BTA-2... | 467 | [
"1bu2",
"1e9h",
"1f5q",
"1fin",
"1fvv",
"1g3n",
"1gy3",
"1h1p",
"1h1q",
"1h1r",
"1h1s",
"1h24",
"1h25",
"1h26",
"1h27",
"1h28",
"1jkw",
"1jow",
"1jst",
"1jsu",
"1kxu",
"1ogu",
"1oi9",
"1oiu",
"1oiy",
"1okv",
"1okw",
"1ol1",
"1ol2",
"1p5e",
"1pkd",
"1qmz"... | 371 | [
"PUB00014101",
"PUB00014103"
] | [
"11056549",
"12910258"
] | [
"Cyclin' on the viral path to destruction.",
"Cell cycle regulation and neural differentiation."
] | [
2000,
2003
] | 2 | [] | [
"IPR047321",
"IPR048026",
"IPR048055"
] | 0 | 3 | 0 | [
"Archaea",
"Eukaryota",
"Spongiibacter pelagi",
"Viruses",
"metagenomes"
] | [
6,
90957,
1,
158,
10
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
216,
29,
96,
43,
129,
101,
7,
105,
114,
16,
11,
339
] | 12 | true | Domain | Cyclin, N-terminal | Cyclin, N-terminal | Cyclin_N | 8 |
IPR006673 | 6,673 | Mnh complex subunit C1 | Mnh_C1_su | Family | 82 | false | false | This entry represents subunit C of the Mnh complex, which is a cation antiporter, involved in K(+) and Na(+) excretion. It shares significant protein sequence similarity with various chains of the NADH-ubiquinone/plastoquinone (complex I) [ ]. | [
"GO:0008324",
"GO:0006812"
] | [
"monoatomic cation transmembrane transporter activity",
"monoatomic cation transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00941"
] | [
"2a6301s03"
] | [
82
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00057356"
] | [
"17293423"
] | [
"Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/proton antiporter-3 (Mrp) family are revealed by an optimized assay in an Escherichia coli host."
] | [
2007
] | 1 | [
"IPR039428"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
82
] | 1 | [] | [] | 0 | true | Family | Mnh complex subunit C1 | Mnh complex subunit C1 | Mnh_C1_su | 3 |
IPR006674 | 6,674 | HD domain | HD_domain | Domain | 194,792 | false | false | The HD domain is found in a superfamily of enzymes with a predicted or known phosphohydrolase activity [ ]. These enzymes appear to be involved in the nucleic acid metabolism, signal transduction and possibly other functions in bacteria, archaea and eukaryotes. The fact that all the highly conserved residues in the HD ... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PROFILE"
] | [
"PF01966",
"PF13023",
"PS51831"
] | [
"HD",
"HD_3",
"HD"
] | [
139901,
13219,
124492
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8956319",
"R-CEL-8956319",
"R-DDI-8956319",
"R-DRE-8956319",
"R-GGA-8956319",
"R-HSA-8956319",
"R-HSA-909733",
"R-MMU-8956319"
] | [
"REACTOME:R-BTA-8956319",
"REACTOME:R-CEL-8956319",
"REACTOME:R-DDI-8956319",
"REACTOME:R-DRE-8956319",
"REACTOME:R-GGA-8956319",
"REACTOME:R-HSA-8956319",
"REACTOME:R-HSA-909733",
"REACTOME:R-MMU-8956319"
] | 8 | [
"1vj7",
"1xx7",
"1ynb",
"1yoy",
"2cqz",
"2dqb",
"2hek",
"2o08",
"2o6i",
"2ogi",
"2paq",
"2par",
"2pau",
"2pgs",
"2pjq",
"2pq7",
"2q14",
"2qgs",
"3b57",
"3bg2",
"3ccg",
"3djb",
"3dto",
"3gw7",
"3irh",
"3kh1",
"3nqw",
"3nr1",
"3u1n",
"3wfo",
"3wfp",
"3wfq"... | 232 | [
"PUB00005837",
"PUB00054925"
] | [
"9868367",
"17951247"
] | [
"The HD domain defines a new superfamily of metal-dependent phosphohydrolases.",
"Phosphodiesterase activity of CvfA is required for virulence in Staphylococcus aureus."
] | [
1998,
2008
] | 2 | [
"IPR003607"
] | [
"IPR006675"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
4052,
167919,
19259,
252,
3310
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
61,
6,
11,
7,
7,
14,
14,
3,
25,
11,
4,
1,
74
] | 13 | true | Domain | HD domain | HD domain | HD_domain | 8 |
IPR006675 | 6,675 | HDIG domain | HDIG_dom | Domain | 54,280 | false | false | This domain is found in a few known nucleotidyltransferases and in a large number of uncharacterised proteins. It contains four widely separated His residues, the second of which is part of an invariant dipeptide His-Asp in a region matched approximately by the motif HDIG. It appears to be related to the HD domain. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00277"
] | [
"HDIG"
] | [
54280
] | 1 | [] | [] | [] | 0 | [
"2pq7",
"3tm8",
"3tmb",
"3tmc",
"3tmd",
"3wfo",
"3wfp",
"3wfq",
"3wfr",
"3wfs",
"4mcw",
"4mdz",
"4me4",
"4mlm",
"4mln",
"4n6w",
"4n71",
"4s1b",
"4s1c",
"8jja",
"8jjk",
"8jk5",
"8jk8",
"8jk9",
"8jka",
"8jkp",
"8jkr",
"8yt5"
] | 28 | [] | [] | [] | [] | 0 | [
"IPR006674"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
1244,
51160,
35,
507,
1334
] | 5 | [
"Arabidopsis thaliana"
] | [
1
] | 1 | true | Domain | HDIG domain | HDIG domain | HDIG_dom | 6 |
IPR006676 | 6,676 | tRNA-splicing endonuclease | tRNA_splic | Family | 6,896 | false | false | tRNA-splicing endonucleases ( ) catalyse the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini [ , ]. The genes encoding these proteins are homologous in eukaryotes and archea. The eukaryo... | [
"GO:0000213",
"GO:0006388"
] | [
"tRNA-intron lyase activity",
"tRNA splicing, via endonucleolytic cleavage and ligation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR21227",
"TIGR00324"
] | [
"",
"endA"
] | [
5302,
3581
] | 2 | [
"EC",
"GP",
"METACYC",
"METACYC",
"REACTOME"
] | [
"4.6.1.16",
"GenProp1707",
"PWY-6689",
"PWY-7803",
"R-HSA-6784531"
] | [
"EC:4.6.1.16",
"GP:GenProp1707",
"METACYC:PWY-6689",
"METACYC:PWY-7803",
"REACTOME:R-HSA-6784531"
] | 5 | [
"1a79",
"1r0v",
"1r11",
"1rlv",
"2cv8",
"2gjw",
"2ohc",
"2ohe",
"2zyz",
"3ajv",
"3iey",
"3p1y",
"3p1z",
"4fz2",
"5x89",
"6z9u",
"7uxa",
"7zrz",
"8hmy",
"8hmz",
"8iss",
"9w2k"
] | 22 | [
"PUB00054270",
"PUB00055529"
] | [
"9321408",
"9200603"
] | [
"RNA-protein interactions of an archaeal homotetrameric splicing endoribonuclease with an exceptional evolutionary history.",
"The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases."
] | [
1997,
1997
] | 2 | [] | [
"IPR016442",
"IPR016589",
"IPR016690",
"IPR023516"
] | 0 | 4 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
973,
3,
5880,
40
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
1,
4,
2,
26,
4,
1,
7,
6,
2,
2,
5
] | 12 | true | Family | tRNA-splicing endonuclease | tRNA-splicing endonuclease | tRNA_splic | 3 |
IPR006677 | 6,677 | tRNA intron endonuclease, catalytic domain-like | tRNA_intron_Endonuc_cat-like | Domain | 8,992 | false | false | This entry represents a three-layer α/β/α domain found as the catalytic domain at the C-terminal in homotetrameric tRNA-intron endonucleases [ ], and as domains 2 and 4 (C-terminal) in the homodimeric enzymes [ ]. tRNA-intron endonucleases ( ) remove tRNA introns by cleaving pre-tRNA at the 5'- and 3'-splice sites to r... | [
"GO:0000213",
"GO:0006388"
] | [
"tRNA-intron lyase activity",
"tRNA splicing, via endonucleolytic cleavage and ligation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"CDD"
] | [
"PF01974",
"cd22363"
] | [
"tRNA_int_endo",
"tRNA-intron_lyase_C"
] | [
8894,
8824
] | 2 | [
"EC",
"METACYC",
"METACYC",
"REACTOME"
] | [
"4.6.1.16",
"PWY-6689",
"PWY-7803",
"R-HSA-6784531"
] | [
"EC:4.6.1.16",
"METACYC:PWY-6689",
"METACYC:PWY-7803",
"REACTOME:R-HSA-6784531"
] | 4 | [
"1a79",
"1r0v",
"1r11",
"1rlv",
"2cv8",
"2gjw",
"2ohc",
"2ohe",
"2zyz",
"3ajv",
"3iey",
"3if0",
"3p1y",
"3p1z",
"4fz2",
"5x89",
"6z9u",
"7uxa",
"7zrz",
"8hmy",
"8hmz",
"8iss",
"9w2k"
] | 23 | [
"PUB00005788",
"PUB00020493",
"PUB00030470",
"PUB00041082"
] | [
"9200602",
"9535656",
"14993668",
"16690865"
] | [
"Properties of H. volcanii tRNA intron endonuclease reveal a relationship between the archaeal and eucaryal tRNA intron processing systems.",
"Crystal structure and evolution of a transfer RNA splicing enzyme.",
"Structure determination of a truncated dimeric splicing endonuclease in pseudo-face-centered space ... | [
1997,
1998,
2004,
2006
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Eukaryota",
"Parcubacteria group",
"unclassified sequences"
] | [
1104,
7828,
2,
58
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
11,
2,
4,
5,
22,
5,
2,
4,
6,
2,
2,
5
] | 12 | true | Domain | tRNA intron endonuclease, catalytic domain-like | tRNA intron endonuclease, catalytic domain-like | tRNA_intron_Endonuc_cat-like | 2 |
IPR006678 | 6,678 | tRNA intron endonuclease, N-terminal | tRNA_intron_Endonuc_N | Domain | 2,776 | false | false | This entry represents a 2-layer α/β domain found at the N terminus of the homotetrameric tRNA-intron endonucleases [ ], and as domains 1 (N-terminal) and 3 in the homodimeric enzymes [ ]. tRNA-intron endonucleases ( ) remove tRNA introns by cleaving pre-tRNA at the 5'- and 3'-splice sites to release the intron. The pro... | [
"GO:0000213",
"GO:0006388"
] | [
"tRNA-intron lyase activity",
"tRNA splicing, via endonucleolytic cleavage and ligation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF02778"
] | [
"tRNA_int_endo_N"
] | [
2776
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME"
] | [
"4.6.1.16",
"PWY-6689",
"PWY-7803",
"R-HSA-6784531"
] | [
"EC:4.6.1.16",
"METACYC:PWY-6689",
"METACYC:PWY-7803",
"REACTOME:R-HSA-6784531"
] | 4 | [
"1a79",
"1r0v",
"1r11",
"1rlv",
"2cv8",
"2gjw",
"2zyz",
"3ajv",
"3iey",
"3p1y",
"3p1z",
"5x89",
"7uxa",
"7zrz",
"8hmy",
"8hmz",
"8iss"
] | 17 | [
"PUB00005788",
"PUB00020493",
"PUB00030470",
"PUB00041082"
] | [
"9200602",
"9535656",
"14993668",
"16690865"
] | [
"Properties of H. volcanii tRNA intron endonuclease reveal a relationship between the archaeal and eucaryal tRNA intron processing systems.",
"Crystal structure and evolution of a transfer RNA splicing enzyme.",
"Structure determination of a truncated dimeric splicing endonuclease in pseudo-face-centered space ... | [
1997,
1998,
2004,
2006
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Eukaryota",
"Parcubacteria group",
"unclassified sequences"
] | [
998,
1734,
2,
42
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus"
] | [
14,
1,
2,
9,
1,
7,
2
] | 7 | true | Domain | tRNA intron endonuclease, N-terminal | tRNA intron endonuclease, N-terminal | tRNA_intron_Endonuc_N | 6 |
IPR006682 | 6,682 | Conserved hypothetical protein CHP00267 | CHP00267 | Family | 68 | false | false | This family of uncharacterised proteins shows a low level of similarity (possibly meaningful) to the predicted membrane protein YLR220W, which is involved in calcium homeostatis. It shows no similarity to any other characterised protein. This family is represented in three of the first four completed archaeal genomes, ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00267"
] | [
""
] | [
68
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR008217"
] | [] | 1 | 0 | 1 | [
"Methanobacteriota",
"marine sediment metagenome"
] | [
67,
1
] | 2 | [] | [] | 0 | true | Family | Conserved hypothetical protein CHP00267 | Conserved hypothetical protein CHP00267 | CHP00267 | 5 |
IPR006683 | 6,683 | Thioesterase domain | Thioestr_dom | Domain | 124,024 | false | false | A wide variety of enzymes contain this domain, principally thioesterases. Proteins containing this domain include 4HBT (4-hydroxybenzoyl-CoA thioesterase) ( ) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3 [ , ]. It also inclu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03061"
] | [
"4HBT"
] | [
124024
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.2",
"GenProp1291",
"GenProp1498",
"GenProp1560",
"GenProp1694",
"R-HSA-1257604",
"R-HSA-165158",
"R-HSA-199418",
"R-HSA-389357",
"R-HSA-5218920",
"R-HSA-77289",
"R-MMU-1257604",
"R-MMU-165158",
"R-MMU-199418",
"R-MMU-389357",
"R-MMU-5218920",
"R-MMU-77289",
"R-RNO-1257604",
... | [
"EC:3.1.2",
"GP:GenProp1291",
"GP:GenProp1498",
"GP:GenProp1560",
"GP:GenProp1694",
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA-165158",
"REACTOME:R-HSA-199418",
"REACTOME:R-HSA-389357",
"REACTOME:R-HSA-5218920",
"REACTOME:R-HSA-77289",
"REACTOME:R-MMU-1257604",
"REACTOME:R-MMU-165158",
"REA... | 24 | [
"1ixl",
"1j1y",
"1psu",
"1q4s",
"1q4t",
"1q4u",
"1s5u",
"1sbk",
"1sc0",
"1vh5",
"1vh9",
"1vi8",
"1vpm",
"1wlu",
"1wlv",
"1wm6",
"1wn3",
"1y7u",
"1yli",
"1zki",
"2b6e",
"2cy9",
"2dsl",
"2eis",
"2f0x",
"2f3x",
"2f41",
"2fs2",
"2gvh",
"2h4u",
"2hbo",
"2ov9"... | 121 | [
"PUB00003031",
"PUB00005275",
"PUB00067938"
] | [
"9837940",
"8805534",
"1610806"
] | [
"The three-dimensional structure of 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. Strain CBS-3.",
"Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site.",
"Isolation and characterization of the three pol... | [
1998,
1996,
1992
] | 3 | [] | [
"IPR003736",
"IPR033120"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1997,
97228,
23468,
9,
1322
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
32,
3,
33,
3,
6,
12,
17,
6,
23,
24,
1,
2,
47
] | 13 | true | Domain | Thioesterase domain | Thioesterase domain | Thioestr_dom | 4 |
IPR006684 | 6,684 | Acyl-CoA thioester hydrolase YbgC/YbaW family | YbgC/YbaW | Family | 21,806 | false | false | This entry describes a subset of related acyl-CoA thioesterases that include several partially characterised proteins. YbgC is an acyl-CoA thioesterase associated with the Tol-Pal system and appears to be involved in phospholipid metabolism [ ]. Long-chain acyl-CoA thioesterase FadM (YbaW) is part of the FadM regulon a... | [
"GO:0016787"
] | [
"hydrolase activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF003230",
"TIGR00051"
] | [
"YbgC",
""
] | [
20414,
18655
] | 2 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"3.1.2.-",
"GenProp1486",
"PWY-3602",
"PWY-5109",
"PWY-6322",
"PWY-6585",
"PWY-6917",
"PWY-6948",
"PWY-6995",
"PWY-6997",
"PWY-7007",
"PWY-7216",
"PWY-7292",
"PWY-7401",
"PWY-7402",
"PWY-7471",
"PWY-7690",
"PWY-7706",
"PWY-7733",
"PWY-7734",
"PWY-7738",
"PWY-7740",
"PWY-7... | [
"EC:3.1.2.-",
"GP:GenProp1486",
"METACYC:PWY-3602",
"METACYC:PWY-5109",
"METACYC:PWY-6322",
"METACYC:PWY-6585",
"METACYC:PWY-6917",
"METACYC:PWY-6948",
"METACYC:PWY-6995",
"METACYC:PWY-6997",
"METACYC:PWY-7007",
"METACYC:PWY-7216",
"METACYC:PWY-7292",
"METACYC:PWY-7401",
"METACYC:PWY-740... | 35 | [
"1njk",
"1s5u",
"1z54",
"2egi",
"2egj",
"2egr",
"2pzh",
"3hm0",
"3r87",
"4i45",
"4k00",
"5kl9",
"5t06",
"5t07",
"5v10",
"5wh9",
"6fdg"
] | 17 | [
"PUB00043444",
"PUB00059311",
"PUB00085107"
] | [
"18338382",
"19684132",
"18576672"
] | [
"Structural and enzymatic characterization of HP0496, a YbgC thioesterase from Helicobacter pylori.",
"A new member of the Escherichia coli fad regulon: transcriptional regulation of fadM (ybaW).",
"Identification and characterization of Escherichia coli thioesterase III that functions in fatty acid beta-oxidat... | [
2008,
2009,
2008
] | 3 | [] | [
"IPR014166"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
139,
21348,
44,
275
] | 4 | [
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica"
] | [
2,
1
] | 2 | true | Family | Acyl-CoA thioester hydrolase YbgC/YbaW family | Acyl-CoA thioester hydrolase YbgC/YbaW family | YbgC/YbaW | 9 |
IPR006685 | 6,685 | Mechanosensitive ion channel MscS | MscS_channel_2nd | Domain | 97,765 | false | false | This entry includes small conductance mechanosensitive channels (MscS), which assembles to a homoheptameric complex [ , , , , , ]. Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antiparallel β-sheet (middle/second) domain and a C-terminal α/β-domai... | [
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF00924"
] | [
"MS_channel_2nd"
] | [
97765
] | 1 | [] | [] | [] | 0 | [
"2oau",
"2vv5",
"3t9n",
"3udc",
"4age",
"4agf",
"4hw9",
"4hwa",
"5aji",
"5y4o",
"6lyp",
"6pwn",
"6pwo",
"6pwp",
"6rld",
"6urt",
"6uzh",
"6vxm",
"6vxn",
"6vxp",
"6vyk",
"6vyl",
"6vym",
"6zyd",
"6zye",
"7a46",
"7dlu",
"7n4t",
"7n5d",
"7n5e",
"7n5f",
"7n5g"... | 63 | [
"PUB00013956",
"PUB00013957",
"PUB00019883",
"PUB00019884",
"PUB00019885",
"PUB00062568",
"PUB00064132",
"PUB00089654",
"PUB00097362",
"PUB00101036",
"PUB00101037"
] | [
"12446901",
"12626684",
"11296222",
"11159397",
"11275684",
"23012406",
"23074248",
"22910366",
"25041276",
"34376558",
"23339071"
] | [
"Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel.",
"Two families of mechanosensitive channel proteins.",
"Structural and functional differences between two homologous mechanosensitive channels of Methanococcus jannaschii.",
"Molecular identification of a mechanose... | [
2002,
2003,
2001,
2001,
2001,
2012,
2012,
2012,
2014,
2021,
2013
] | 11 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
3854,
82017,
10823,
5,
1066
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
44,
6,
2,
16,
2,
29
] | 6 | true | Domain | Mechanosensitive ion channel MscS | Mechanosensitive ion channel MscS | MscS_channel_2nd | 1 |
IPR006686 | 6,686 | Mechanosensitive ion channel MscS, conserved site | MscS_channel_CS | Conserved_site | 13,722 | false | false | MscS is a mechanosensitive channel present in the membrane of bacteria, archaea and eukarya that responds both to stretching of the cell membrane and to membrane depolarisation [ ]. MscS folds as a homo-heptamer with a cylindrical shape, and can be divided into transmembrane and extramembrane regions: an N-terminal per... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PROSITE"
] | [
"PS01246"
] | [
"UPF0003"
] | [
13722
] | 1 | [
"PROSITEDOC"
] | [
"PDOC00959"
] | [
"PROSITEDOC:PDOC00959"
] | 1 | [
"2oau",
"2vv5",
"4age",
"4agf",
"4hwa",
"5aji",
"5y4o",
"6pwn",
"6pwo",
"6pwp",
"6rld",
"6urt",
"6uzh",
"6vyk",
"6vyl",
"6vym",
"6zyd",
"6zye",
"7dlu",
"7n4t",
"7onj",
"7onl",
"7oo0",
"7oo6",
"7oo8",
"7ooa",
"7raz",
"7uw5",
"7ux1",
"8ddj",
"9e62",
"9e63"... | 41 | [
"PUB00013956"
] | [
"12446901"
] | [
"Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
509,
13086,
41,
86
] | 4 | [
"Escherichia coli (strain K12)"
] | [
4
] | 1 | true | Conserved_site | Mechanosensitive ion channel MscS, conserved site | Mechanosensitive ion channel MscS, conserved site | MscS_channel_CS | 3 |
IPR006689 | 6,689 | Small GTPase superfamily, ARF/SAR type | Small_GTPase_ARF/SAR | Family | 78,653 | false | false | This entry represents a branch of the small GTPase superfamily that includes the ADP ribosylation factor Arf, Arl (Arf-like), Arp (Arf-related proteins) and the remotely related Sar (Secretion-associated and Ras-related) proteins. Arf proteins are major regulators of vesicle biogenesis in intracellular traffic [ ]. The... | [
"GO:0003924",
"GO:0005525"
] | [
"GTPase activity",
"GTP binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"PRINTS",
"SMART"
] | [
"PF00025",
"PR00328",
"SM00178"
] | [
"Arf",
"SAR1GTPBP",
"SAR"
] | [
78301,
62253,
61882
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1660499",
"R-BTA-1660514",
"R-BTA-199992",
"R-BTA-204005",
"R-BTA-2132295",
"R-BTA-432720",
"R-BTA-432722",
"R-BTA-5620916",
"R-BTA-5620922",
"R-BTA-5694530",
"R-BTA-6807878",
"R-BTA-6811434",
"R-BTA-6811438",
"R-BTA-6811440",
"R-BTA-83936",
"R-BTA-8963888",
"R-BTA-9648002",
... | [
"REACTOME:R-BTA-1660499",
"REACTOME:R-BTA-1660514",
"REACTOME:R-BTA-199992",
"REACTOME:R-BTA-204005",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-432720",
"REACTOME:R-BTA-432722",
"REACTOME:R-BTA-5620916",
"REACTOME:R-BTA-5620922",
"REACTOME:R-BTA-5694530",
"REACTOME:R-BTA-6807878",
"REACTOME:R-... | 184 | [
"1e0s",
"1f6b",
"1fzq",
"1hur",
"1j2j",
"1ksg",
"1ksh",
"1ksj",
"1m2o",
"1moz",
"1mr3",
"1o3y",
"1r4a",
"1r8q",
"1r8s",
"1re0",
"1rrf",
"1rrg",
"1s9d",
"1u81",
"1upt",
"1yzg",
"1z6x",
"1z6y",
"1zd9",
"1zj6",
"2a5d",
"2a5f",
"2a5g",
"2al7",
"2b6h",
"2fa9"... | 224 | [
"PUB00000348",
"PUB00004087",
"PUB00009830",
"PUB00015117",
"PUB00023196",
"PUB00052600"
] | [
"2029511",
"1898771",
"12429613",
"11995995",
"2196171",
"2122258"
] | [
"The ras protein family: evolutionary tree and role of conserved amino acids.",
"The GTPase superfamily: conserved structure and molecular mechanism.",
"Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication.",
"Structure of small G proteins an... | [
1991,
1991,
2002,
2001,
1990,
1990
] | 6 | [] | [
"IPR006687",
"IPR041838",
"IPR041839",
"IPR042951",
"IPR044154",
"IPR044612",
"IPR045872"
] | 0 | 7 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
133,
886,
77447,
2,
185
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
75,
14,
82,
26,
124,
87,
7,
57,
128,
7,
4,
147
] | 12 | true | Family | Small GTPase superfamily, ARF/SAR type | Small GTPase superfamily, ARF/SAR type | Small_GTPase_ARF/SAR | 2 |
IPR006690 | 6,690 | Outer membrane protein, OmpA-like, conserved site | OMPA-like_CS | Conserved_site | 20,754 | false | false | Most of the bacterial outer membrane proteins in this group are porin-like integral membrane proteins (such as ompA) [ ], but some are small lipid-anchored proteins (such as pal) [ ]. It is also found in MotB and related proteins. They are present in the outer membrane of many Gram-negative organisms [ ]. This domain i... | [
"GO:0009279",
"GO:0016020"
] | [
"cell outer membrane",
"membrane"
] | [
"cellular_component",
"cellular_component"
] | 2 | [
"PROSITE"
] | [
"PS01068"
] | [
"OMPA_1"
] | [
20754
] | 1 | [
"PROSITEDOC"
] | [
"PDOC00819"
] | [
"PROSITEDOC:PDOC00819"
] | 1 | [
"1oap",
"1r1m",
"2aiz",
"2hqs",
"2k1s",
"2kgw",
"2l26",
"2lbt",
"2lca",
"2mqe",
"2n48",
"2w8b",
"2zf8",
"3nb3",
"4b5c",
"4erh",
"4g4v",
"4g4w",
"4g4x",
"4pwt",
"4r40",
"4rha",
"5lkw",
"5n2c",
"5nhx",
"5u1h",
"5ves",
"8z5n",
"8z60"
] | 29 | [
"PUB00003748",
"PUB00006250",
"PUB00006564"
] | [
"1538702",
"2202726",
"10515919"
] | [
"Homology of the root adhesin of Pseudomonas fluorescens OE 28.3 with porin F of P. aeruginosa and P. syringae.",
"Export and sorting of the Escherichia coli outer membrane protein OmpA.",
"In vitro characterization of peptidoglycan-associated lipoprotein (PAL)-peptidoglycan and PAL-TolB interactions."
] | [
1992,
1990,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
20588,
33,
2,
131
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Conserved_site | Outer membrane protein, OmpA-like, conserved site | Outer membrane protein, OmpA-like, conserved site | OMPA-like_CS | 1 |
IPR006691 | 6,691 | DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat | GyrA/parC_rep | Repeat | 46,586 | false | false | This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 β strands and to probably form a β-propeller structure [ ]. This region has been shown to bind DNA non-specifically and may stabilise the DNA-topoisomerase complex [ ]. | [
"GO:0003677",
"GO:0003916",
"GO:0005524",
"GO:0006265"
] | [
"DNA binding",
"DNA topoisomerase activity",
"ATP binding",
"DNA topological change"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 4 | [
"PFAM"
] | [
"PF03989"
] | [
"DNA_gyraseA_C"
] | [
46586
] | 1 | [
"EC",
"REACTOME",
"REACTOME"
] | [
"5.6.2.2",
"R-HSA-9638771",
"R-HSA-9913143"
] | [
"EC:5.6.2.2",
"REACTOME:R-HSA-9638771",
"REACTOME:R-HSA-9913143"
] | 3 | [
"1suu",
"1wp5",
"1zi0",
"1zvt",
"1zvu",
"3l6v",
"3no0",
"3uc1",
"4g3n",
"4mn4",
"5ztj",
"6rks",
"6rku",
"6rkv",
"6rkw",
"7z9c",
"7z9g",
"7z9k",
"7z9m",
"8qdx",
"8qqs",
"8qqu",
"8s7k",
"8s7o",
"9gbv",
"9ggq"
] | 26 | [
"PUB00008991",
"PUB00009362"
] | [
"1657531",
"11948780"
] | [
"DNA gyrase: structure and function.",
"C-terminal domain of gyrase A is predicted to have a beta-propeller structure."
] | [
1991,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
562,
44097,
1064,
21,
842
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
2,
5,
12
] | 4 | true | Repeat | DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat | DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat | GyrA/parC_rep | 7 |
IPR006693 | 6,693 | Partial AB-hydrolase lipase domain | AB_hydrolase_lipase | Domain | 13,814 | false | false | The alpha/beta hydrolase fold is common to several hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is similar: an α/β sheet, not barrel, of eight β-sheets connected by α-helices [ ]. This entry represents the N-terminal part of an alpha/beta hydrolase domain fo... | [
"GO:0006629"
] | [
"lipid metabolic process"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF04083"
] | [
"Abhydro_lipase"
] | [
13814
] | 1 | [
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.1",
"GenProp1558",
"R-HSA-6809371",
"R-MMU-192456",
"R-RNO-192456",
"R-SCE-192456",
"R-SCE-6809371",
"R-SPO-192456",
"R-SPO-6809371"
] | [
"EC:3.1.1",
"GP:GenProp1558",
"REACTOME:R-HSA-6809371",
"REACTOME:R-MMU-192456",
"REACTOME:R-RNO-192456",
"REACTOME:R-SCE-192456",
"REACTOME:R-SCE-6809371",
"REACTOME:R-SPO-192456",
"REACTOME:R-SPO-6809371"
] | 9 | [] | 0 | [
"PUB00004958"
] | [
"1409539"
] | [
"The alpha/beta hydrolase fold."
] | [
1992
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Eukaryota"
] | [
5,
13809
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S... | [
24,
8,
33,
5,
9,
2,
15,
6,
2,
2,
20
] | 11 | true | Domain | Partial AB-hydrolase lipase domain | Partial AB-hydrolase lipase domain | AB_hydrolase_lipase | 8 |
IPR006696 | 6,696 | Protein of unknown function DUF423 | DUF423 | Family | 14,609 | false | false | This is a potential integral membrane protein with no known function. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04241",
"PTHR43461"
] | [
"DUF423",
""
] | [
14601,
13353
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
11432,
3069,
108
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
5,
1,
1,
5,
1,
2,
2,
1,
2,
5,
1,
24
] | 12 | true | Family | Protein of unknown function DUF423 | Protein of unknown function DUF423 | DUF423 | 4 |
IPR006697 | 6,697 | RecBCD enzyme subunit RecC | RecC | Family | 7,764 | false | false | The exodeoxyribonuclease V enzyme or RecBCD enzyme is a multisubunit enzyme comprised of the proteins RecB ( ), RecC (this family) and RecD ( ). This enzyme plays an important role in homologous genetic recombination, repair of double strand DNA breaks resistance to UV irradiation and chemical DNA-damage. The enzyme ( ... | [
"GO:0008854",
"GO:0009338"
] | [
"exodeoxyribonuclease V activity",
"exodeoxyribonuclease V complex"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"HAMAP",
"PIRSF",
"NCBIFAM"
] | [
"MF_01486",
"PIRSF000980",
"TIGR01450"
] | [
"RecC",
"RecC",
"recC"
] | [
7560,
7532,
7260
] | 3 | [
"GP",
"GP"
] | [
"GenProp0216",
"GenProp1188"
] | [
"GP:GenProp0216",
"GP:GenProp1188"
] | 2 | [
"1w36",
"3k70",
"5ld2",
"5mbv",
"6sjb",
"6sje",
"6sjf",
"6sjg",
"6t2u",
"6t2v",
"7mr0",
"7mr1",
"7mr2",
"7mr3",
"7mr4",
"8b1r",
"8b1t",
"8b1u"
] | 18 | [
"PUB00008491",
"PUB00109221",
"PUB00163311"
] | [
"7746848",
"31907455",
"2593567"
] | [
"The initiation and control of homologous recombination in Escherichia coli.",
"A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair.",
"[Diagnosis and treatment of recurrences of peptic ulcer after selective proximal vagotomy]."
] | [
1995,
2020,
1989
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
7701,
8,
55
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | RecBCD enzyme subunit RecC | RecBCD enzyme subunit RecC | RecC | 9 |
IPR006699 | 6,699 | Glycerol uptake operon antiterminator | GlpP | Family | 3,982 | false | false | Glycerol enters bacterial cells via facilitated diffusion, an energy-independent transport process catalysed by the glycerol transport facilitator GlpF, an integral membrane protein of the aquaporin family. Intracellular glycerol is usually converted to glycerol-3-P in an ATP-requiring phosphorylation reaction catalyse... | [
"GO:0006071",
"GO:0006355"
] | [
"glycerol metabolic process",
"regulation of DNA-templated transcription"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF04309",
"PIRSF016897",
"PTHR35787"
] | [
"G3P_antiterm",
"GlpP",
""
] | [
3982,
3866,
3962
] | 3 | [] | [] | [] | 0 | [
"1vkf",
"3kts"
] | 2 | [
"PUB00008492"
] | [
"1809833"
] | [
"Expression of the gene encoding glycerol-3-phosphate dehydrogenase (glpD) in Bacillus subtilis is controlled by antitermination."
] | [
1991
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3953,
5,
24
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Glycerol uptake operon antiterminator | Glycerol uptake operon antiterminator | GlpP | 4 |
IPR006700 | 6,700 | Ribosomal RNA small subunit methyltransferase E | RsmE | Family | 28,144 | false | false | Methyltransferases (Mtases) are responsible for the transfer of methyl groups between two molecules. The transfer of the methyl group from the ubiquitous S-adenosyl-L-methionine (AdoMet) to either nitrogen, oxygen or carbon atoms is frequently employed in diverse organisms. The reaction is catalysed by Mtases and modif... | [
"GO:0008168",
"GO:0006364"
] | [
"methyltransferase activity",
"rRNA processing"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PIRSF015601",
"PTHR30027",
"TIGR00046"
] | [
"MTase_slr0722",
"",
""
] | [
26540,
28072,
27957
] | 3 | [
"EC"
] | [
"2.1.1.193"
] | [
"EC:2.1.1.193"
] | 1 | [
"1nxz",
"1v6z",
"1vhk",
"1vhy",
"1z85",
"2cx8",
"2egv",
"2egw",
"2z0y",
"3kw2",
"4e8b",
"4j3c",
"4l69",
"5o95",
"5o96",
"5vm8"
] | 16 | [
"PUB00029267",
"PUB00044729",
"PUB00044730",
"PUB00062463"
] | [
"14517985",
"16431987",
"7872509",
"22925577"
] | [
"Functional assignment based on structural analysis: crystal structure of the yggJ protein (HI0303) of Haemophilus influenzae reveals an RNA methyltransferase with a deep trefoil knot.",
"Identification and characterization of RsmE, the founding member of a new RNA base methyltransferase family.",
"Quantitative... | [
2003,
2006,
1994,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Marine Group I thaumarchaeote",
"unclassified sequences"
] | [
26511,
1062,
1,
570
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
1,
3,
7
] | 4 | true | Family | Ribosomal RNA small subunit methyltransferase E | Ribosomal RNA small subunit methyltransferase E | RsmE | 1 |
IPR006702 | 6,702 | Casparian strip membrane protein domain | CASP_dom | Domain | 19,200 | false | false | This domain is found mainly in plant proteins known as Casparian strip membrane proteins (CASPs). CASPs are four-membrane-span proteins that mediate the deposition of Casparian strips in the endodermis by recruiting the lignin polymerization machinery. Interestingly, the CASP first extracellular loop was found conserve... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04535"
] | [
"CASP_dom"
] | [
19200
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00072979",
"PUB00088572"
] | [
"24920445",
"21593871"
] | [
"Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE DOMAIN PROTEIN family.",
"A novel protein family mediates Casparian strip formation in the endodermis."
] | [
2014,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
19200
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
137,
68,
149
] | 3 | true | Domain | Casparian strip membrane protein domain | Casparian strip membrane protein domain | CASP_dom | 2 |
IPR006703 | 6,703 | AIG1-type guanine nucleotide-binding (G) domain | G_AIG1 | Domain | 31,834 | false | false | This entry represents the AIG1-type G domain. The P-loop guanosine triphosphatases (GTPases) control a multitude of biological processes, ranging from cell division, cell cycling, and signal transduction, to ribosome assembly and protein synthesis. GTPases exert their control by interchanging between an inactive GDP-bo... | [
"GO:0005525"
] | [
"GTP binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE"
] | [
"PF04548",
"PS51720"
] | [
"AIG1",
"G_AIG1"
] | [
31819,
24620
] | 2 | [] | [] | [] | 0 | [
"1h65",
"2j3e",
"2xtm",
"2xtn",
"2xto",
"2xtp",
"3bb1",
"3bb3",
"3bb4",
"3def",
"3lxx",
"3p1j",
"3v70",
"3zjc",
"6z3e",
"7vcf",
"7xzi",
"7xzj"
] | 18 | [
"PUB00013952",
"PUB00047782",
"PUB00050571",
"PUB00066172",
"PUB00072526"
] | [
"11916378",
"17337454",
"18400179",
"21059949",
"15474311"
] | [
"Classification and evolution of P-loop GTPases and related ATPases.",
"Dimerization is important for the GTPase activity of chloroplast translocon components atToc33 and psToc159.",
"The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures.",
"Struc... | [
2002,
2007,
2008,
2010,
2004
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"marine sediment metagenome"
] | [
42,
31625,
166,
1
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
119,
295,
24,
18,
29,
24,
56
] | 7 | true | Domain | AIG1-type guanine nucleotide-binding (G) domain | AIG1-type guanine nucleotide-binding (G) domain | G_AIG1 | 8 |
IPR006704 | 6,704 | Leukocyte surface antigen CD47 | CD47 | Family | 1,306 | false | false | Leukocyte surface antigen CD47 (also known as integrin-associated protein, IAP) is a widely expressed membrane protein with multiple functions in immunological and neuronal processes. For example, CD47-induces caspase-independent cell death which may be mediated by cytoskeleton reorganisation [ ]. In red blood cells, C... | [
"GO:0070053",
"GO:0022409",
"GO:0050729",
"GO:0050766",
"GO:0005886"
] | [
"thrombospondin receptor activity",
"positive regulation of cell-cell adhesion",
"positive regulation of inflammatory response",
"positive regulation of phagocytosis",
"plasma membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"PANTHER"
] | [
"PTHR10613"
] | [
""
] | [
1306
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-202733",
"R-HSA-216083",
"R-HSA-391160",
"R-HSA-6798695",
"R-MMU-202733",
"R-MMU-216083",
"R-MMU-391160",
"R-MMU-6798695",
"R-RNO-202733",
"R-RNO-216083",
"R-RNO-391160",
"R-RNO-6798695",
"R-SSC-202733",
"R-SSC-216083",
"R-SSC-391160",
"R-SSC-6798695"
] | [
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-391160",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-202733",
"REACTOME:R-MMU-216083",
"REACTOME:R-MMU-391160",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-202733",
"REACTOME:R-RNO-216083",
"REACTOME:R-RNO-391160",
"REACTOME:R-RNO-6... | 16 | [
"2jjs",
"2jjt",
"2vsc",
"4cmm",
"4kjy",
"5iwl",
"5tz2",
"5tzt",
"5tzu",
"7myz",
"7wn8",
"7xjf",
"7ygg",
"8rp8",
"8zca"
] | 15 | [
"PUB00007985",
"PUB00007986",
"PUB00007987",
"PUB00095391"
] | [
"12351399",
"11986200",
"11980922",
"8551630"
] | [
"Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization.",
"Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice.",
"Interactions of thrombospondins with alpha4beta1 integrin and ... | [
2002,
2002,
2002,
1996
] | 4 | [] | [] | 0 | 0 | null | [
"Chordopoxvirinae",
"Euteleostomi"
] | [
100,
1206
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
10,
13
] | 3 | true | Family | Leukocyte surface antigen CD47 | Leukocyte surface antigen CD47 | CD47 | 2 |
IPR006706 | 6,706 | Extensin domain | Extensin_dom | Domain | 2,117 | false | false | Extensins shares protein sequence similarity with hydroxyproline-rich glycoproteins (HRGPs) found in the plant extracellular matrix. They form a structural component which strengthens the primary cell wall; they can account for up to 20% of the dry weight of the cell wall. The key to the role of HRGPs in cell wall self... | [
"GO:0005199",
"GO:0009664"
] | [
"structural constituent of cell wall",
"plant-type cell wall organization"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF04554"
] | [
"Extensin_2"
] | [
2117
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00066811"
] | [
"23578334"
] | [
"Self-rescue of an EXTENSIN mutant reveals alternative gene expression programs and candidate proteins for new cell wall assembly in Arabidopsis."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
3,
2114
] | 2 | [
"Arabidopsis thaliana"
] | [
73
] | 1 | true | Domain | Extensin domain | Extensin domain | Extensin_dom | 7 |
IPR006707 | 6,707 | Type VII secretion system membrane protein EccD | T7SS_EccD | Family | 5,754 | false | false | This entry represents the EccD family of proteins, which includes EccD1-5. EccD1, also known as Snm4, has a ubiquitin-like fold and forms a dimer, with a negatively charged groove which indicates that it likely interacts with positive charged partners and may recruit other T7SS components or secretion substrates or it ... | [] | [] | [] | 0 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF017804",
"TIGR03920"
] | [
"Secretion_EccD1",
"T7SS_EccD"
] | [
4193,
5752
] | 2 | [
"GP"
] | [
"GenProp0904"
] | [
"GP:GenProp0904"
] | 1 | [
"6lar",
"6sgw",
"6sgx",
"6sgz",
"6umm",
"7b9f",
"7b9s",
"7np7",
"7npr",
"7npt",
"7npu",
"7npv"
] | 12 | [
"PUB00053896",
"PUB00053901",
"PUB00053902",
"PUB00093032"
] | [
"19876390",
"14557536",
"16368961",
"26922638"
] | [
"Systematic genetic nomenclature for type VII secretion systems.",
"Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system.",
"Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.",
"Structures of EccB1 ... | [
2009,
2003,
2006,
2016
] | 4 | [
"IPR024962"
] | [] | 1 | 0 | 1 | [
"Bacillati",
"metagenomes"
] | [
5749,
5
] | 2 | [] | [] | 0 | true | Family | Type VII secretion system membrane protein EccD | Type VII secretion system membrane protein EccD | T7SS_EccD | 9 |
IPR006708 | 6,708 | Pex19 protein | Pex19 | Family | 4,396 | false | false | Peroxisome(s) form an intracellular compartment, bounded by a typical lipid bilayer membrane. Peroxisome functions are often specialised by organism and cell type; two widely distributed and well-conserved functions are H2O2-based respiration and fatty acid beta-oxidation. Other functions include ether lipid (plasmalog... | [
"GO:0005777"
] | [
"peroxisome"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04614",
"PTHR12774"
] | [
"Pex19",
""
] | [
4369,
4259
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1369062",
"R-BTA-9603798",
"R-CEL-1369062",
"R-CEL-9603798",
"R-DDI-1369062",
"R-DDI-9603798",
"R-HSA-1369062",
"R-HSA-9603798",
"R-MMU-1369062",
"R-MMU-9603798",
"R-RNO-1369062",
"R-RNO-9603798",
"R-SCE-1369062",
"R-SCE-9603798",
"R-SPO-9603798"
] | [
"REACTOME:R-BTA-1369062",
"REACTOME:R-BTA-9603798",
"REACTOME:R-CEL-1369062",
"REACTOME:R-CEL-9603798",
"REACTOME:R-DDI-1369062",
"REACTOME:R-DDI-9603798",
"REACTOME:R-HSA-1369062",
"REACTOME:R-HSA-9603798",
"REACTOME:R-MMU-1369062",
"REACTOME:R-MMU-9603798",
"REACTOME:R-RNO-1369062",
"REACTOM... | 15 | [
"2wl8",
"5lnf"
] | 2 | [
"PUB00056487"
] | [
"20531392"
] | [
"The peroxisomal receptor Pex19p forms a helical mPTS recognition domain."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Olivibacter ginsenosidimutans",
"bird metagenome"
] | [
4394,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
2,
4,
10,
2,
1,
3,
12,
1,
1,
9
] | 12 | true | Family | Pex19 protein | Pex19 protein | Pex19 | 4 |
IPR006709 | 6,709 | Small-subunit processome, Utp14 | SSU_processome_Utp14 | Family | 5,259 | false | false | A large ribonuclear protein complex is required for the processing of the small-ribosomal-subunit rRNA -the small-subunit (SSU) processome [ , ]. This preribosomal complex contains the U3 snoRNA and at least 40 proteins, which have the following properties: They are nucleolar. They are able to coimmunoprecipitate with ... | [
"GO:0006364",
"GO:0032040"
] | [
"rRNA processing",
"small-subunit processome"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PANTHER"
] | [
"PTHR14150"
] | [
""
] | [
5259
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6791226",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-BTA-6791226",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 6 | [
"5oql",
"5wlc",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqg",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t",
"7d63",
"7mq8",
"7mq9",
"7mqa",
"7suk",
"7wts"... | 49 | [
"PUB00008496",
"PUB00035836",
"PUB00035837"
] | [
"12068309",
"15590835",
"15489292"
] | [
"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.",
"The small-subunit processome is a ribosome assembly intermediate.",
"RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
] | [
2002,
2004,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5259
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
19,
1,
2,
9,
6,
6,
1,
3,
7,
1,
1,
10
] | 12 | true | Family | Small-subunit processome, Utp14 | Small-subunit processome, Utp14 | SSU_processome_Utp14 | 8 |
IPR006710 | 6,710 | Glycoside hydrolase, family 43 | Glyco_hydro_43 | Family | 66,423 | false | false | O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,... | [
"GO:0004553",
"GO:0005975"
] | [
"hydrolase activity, hydrolyzing O-glycosyl compounds",
"carbohydrate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF04616"
] | [
"Glyco_hydro_43"
] | [
66423
] | 1 | [
"CAZY",
"EC",
"EC"
] | [
"GH43",
"3.2.1",
"3.2.1.99"
] | [
"CAZY:GH43",
"EC:3.2.1",
"EC:3.2.1.99"
] | 3 | [
"1gyd",
"1gye",
"1gyh",
"1uv4",
"1wl7",
"1y7b",
"1yi7",
"1yif",
"1yrz",
"2exh",
"2exi",
"2exj",
"2exk",
"2x8f",
"2x8s",
"2x8t",
"3akf",
"3akg",
"3akh",
"3aki",
"3c2u",
"3c7e",
"3c7f",
"3c7g",
"3c7h",
"3c7o",
"3cu9",
"3d5y",
"3d5z",
"3d60",
"3d61",
"3k1u"... | 126 | [
"PUB00004870",
"PUB00005266"
] | [
"7624375",
"8535779"
] | [
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases."
] | [
1995,
1995
] | 2 | [] | [
"IPR016828",
"IPR016840"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
109,
48790,
17248,
2,
274
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
1,
5,
6,
14
] | 5 | true | Family | Glycoside hydrolase, family 43 | Glycoside hydrolase, family 43 | Glyco_hydro_43 | 7 |
IPR006712 | 6,712 | HD-ZIP protein, N-terminal | HD-ZIP_N | Domain | 1,978 | false | false | Homeodomain leucine zipper (HDZip) genes encode putative transcription factors that are unique to plants. This observation suggests that homeobox-leucine zipper genes evolved after the divergence of plants and animals, perhaps to mediate specific regulatory events [ ]. This domain is the N-terminal of plant homeobox-le... | [
"GO:0005634"
] | [
"nucleus"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF04618"
] | [
"HD-ZIP_N"
] | [
1978
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007988"
] | [
"7915839"
] | [
"Structure of homeobox-leucine zipper genes suggests a model for the evolution of gene families."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1978
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
20,
6,
4
] | 3 | true | Domain | HD-ZIP protein, N-terminal | HD-ZIP protein, N-terminal | HD-ZIP_N | 5 |
IPR006713 | 6,713 | Adhesin, Dr-family | Adhesin_Dr | Family | 68 | false | false | The Afa/Dr family of adhesins bind to the Dr blood group antigen component of decay-accelerating factor. These proteins contain both fimbriated and afimbriated adherence structures and mediate adherence of uropathogenic Escherichia coli to the urinary tract, leading to urinary tract infections (UTIs) and pregnancy comp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04619"
] | [
"Adhesin_Dr"
] | [
68
] | 1 | [] | [] | [] | 0 | [
"1rxl",
"1usq",
"1usz",
"1ut1",
"1ut2",
"2bcm",
"2ixq",
"2jkj",
"2jkl",
"2jkn",
"2ver",
"2w5p"
] | 12 | [
"PUB00008499",
"PUB00008500",
"PUB00099772",
"PUB00099773"
] | [
"9169726",
"1670929",
"25278576",
"31917805"
] | [
"Distribution of drb genes coding for Dr binding adhesins among uropathogenic and fecal Escherichia coli isolates and identification of new subtypes.",
"Molecular structure of the Dr adhesin: nucleotide sequence and mapping of receptor-binding domain by use of fusion constructs.",
"Pathogenesis of human diffuse... | [
1997,
1991,
2014,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Escherichia coli"
] | [
68
] | 1 | [] | [] | 0 | true | Family | Adhesin, Dr-family | Adhesin, Dr-family | Adhesin_Dr | 9 |
IPR006714 | 6,714 | Flagellar filament outer layer protein FlaA | FlaA | Family | 831 | false | false | Periplasmic flagella are the organelles of spirochete mobility, and are structurally different from the flagella of other motile bacteria. They reside inside the cell within the periplasmic space, and confer mobility in viscous gel-like media such as connective tissue [ ]. The flagella are composed of an outer sheath o... | [
"GO:0071973",
"GO:0030288"
] | [
"bacterial-type flagellum-dependent cell motility",
"outer membrane-bounded periplasmic space"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF04620"
] | [
"FlaA"
] | [
831
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008501",
"PUB00008502"
] | [
"2194955",
"8990312"
] | [
"Expression in Escherichia coli of the 37-kilodalton endoflagellar sheath protein of Treponema pallidum by use of the polymerase chain reaction and a T7 expression system.",
"An unexpected flaA homolog is present and expressed in Borrelia burgdorferi."
] | [
1990,
1997
] | 2 | [] | [
"IPR016369"
] | 0 | 1 | 0 | [
"Bacteria",
"Menopon gallinae",
"marine sediment metagenome"
] | [
828,
1,
2
] | 3 | [] | [] | 0 | true | Family | Flagellar filament outer layer protein FlaA | Flagellar filament outer layer protein FlaA | FlaA | 1 |
IPR006715 | 6,715 | PEA3-type ETS-domain transcription factor, N-terminal | ETS_PEA3_N | Domain | 4,304 | false | false | The N-terminal of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding [ ]. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N-terminal region contains conserved MAP kinase phosphorylation sites [ ]. | [
"GO:0003700",
"GO:0006355",
"GO:0005634"
] | [
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF04621"
] | [
"ETS_PEA3_N"
] | [
4304
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5687128",
"R-MMU-5687128"
] | [
"REACTOME:R-HSA-5687128",
"REACTOME:R-MMU-5687128"
] | 2 | [] | 0 | [
"PUB00008503",
"PUB00008504"
] | [
"9259977",
"9285689"
] | [
"Structure-function relationships of the PEA3 group of Ets-related transcription factors.",
"Differential expression patterns of the PEA3 group transcription factors through murine embryonic development."
] | [
1997,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
4304
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
20,
18,
14
] | 4 | true | Domain | PEA3-type ETS-domain transcription factor, N-terminal | PEA3-type ETS-domain transcription factor, N-terminal | ETS_PEA3_N | 7 |
IPR006716 | 6,716 | ERG2/sigma1 receptor-like | ERG2_sigma1_rcpt-like | Family | 3,617 | false | false | This family consists of the fungal C-8 sterol isomerase and mammalian sigma1 receptor. C-8 sterol isomerase (delta-8--delta-7 sterol isomerase), catalyses a reaction in ergosterol biosynthesis, which results in unsaturation at C-7 in the B ring of sterols [ ]. Sigma 1 receptor is a low molecular mass mammalian protein ... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF04622",
"PTHR10868"
] | [
"ERG2_Sigma1R",
""
] | [
3388,
3551
] | 2 | [
"GP",
"REACTOME"
] | [
"GenProp1609",
"R-HSA-9679191"
] | [
"GP:GenProp1609",
"REACTOME:R-HSA-9679191"
] | 2 | [
"5hk1",
"5hk2",
"6djz",
"6dk0",
"6dk1",
"7w2b",
"7w2c",
"7w2d",
"7w2e",
"7w2f",
"7w2g",
"7w2h",
"8w4b",
"8w4c",
"8w4d",
"8w4e",
"8wue",
"8wwb",
"8ybb"
] | 19 | [
"PUB00008505",
"PUB00008506",
"PUB00008507"
] | [
"8082205",
"8755605",
"9425306"
] | [
"Isolation of the ERG2 gene, encoding sterol delta 8-->delta 7 isomerase, from the rice blast fungus Magnaporthe grisea and its expression in the maize smut pathogen Ustilago maydis.",
"Purification, molecular cloning, and expression of the mammalian sigma1-binding site.",
"Cloning and structural analysis of th... | [
1994,
1996,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
77,
3539,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
6,
1,
1,
7,
2,
1,
5,
4,
1,
1,
3
] | 11 | true | Family | ERG2/sigma1 receptor-like | ERG2/sigma1 receptor-like | ERG2_sigma1_rcpt-like | 7 |
IPR006717 | 6,717 | Adenovirus E1B protein, N-terminal | Adeno_E1B_55K_N | Domain | 369 | false | false | This domain constitutes the N-terminal of E1B 55kDa ( ). E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA into an unregulated repressor of genes with a p53 binding site [ ]. This protects the virus against p53 induced host anitviral responses a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04623"
] | [
"Adeno_E1B_55K_N"
] | [
369
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003708"
] | [
"10207064"
] | [
"Corepressor required for adenovirus E1B 55,000-molecular-weight protein repression of basal transcription."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Mastadenovirus"
] | [
369
] | 1 | [] | [] | 0 | true | Domain | Adenovirus E1B protein, N-terminal | Adenovirus E1B protein, N-terminal | Adeno_E1B_55K_N | 8 |
IPR006718 | 6,718 | Dec-1 repeat | DEC-1_REPEAT | Repeat | 80 | false | false | The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing [ ]. Cleavage products include S80 (80kDa) which is incorporated into the eggshell, and further ... | [
"GO:0005213",
"GO:0007304",
"GO:0005576",
"GO:0042600"
] | [
"structural constituent of egg chorion",
"chorion-containing eggshell formation",
"extracellular region",
"egg chorion"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PFAM"
] | [
"PF04624"
] | [
"Dec-1"
] | [
80
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008509",
"PUB00008510"
] | [
"1699826",
"8350348"
] | [
"Multiple proteins are produced from the dec-1 eggshell gene in Drosophila by alternative RNA splicing and proteolytic cleavage events.",
"Evolution of the dec-1 eggshell locus in Drosophila. II. Intraspecific DNA sequence analysis reveals length mutations in a repetitive region in D. melanogaster."
] | [
1990,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Drosophilinae"
] | [
80
] | 1 | [
"Drosophila melanogaster"
] | [
7
] | 1 | true | Repeat | Dec-1 repeat | Dec-1 repeat | DEC-1_REPEAT | 5 |
IPR006719 | 6,719 | DEC-1 protein, N-terminal | DEC-1_N | Domain | 126 | false | false | The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing [ ]. Cleavage products include S80 (80kDa) which is incorporated into the eggshell, and further ... | [
"GO:0005213",
"GO:0007304",
"GO:0005576",
"GO:0042600"
] | [
"structural constituent of egg chorion",
"chorion-containing eggshell formation",
"extracellular region",
"egg chorion"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PFAM"
] | [
"PF04625"
] | [
"DEC-1_N"
] | [
126
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008509"
] | [
"1699826"
] | [
"Multiple proteins are produced from the dec-1 eggshell gene in Drosophila by alternative RNA splicing and proteolytic cleavage events."
] | [
1990
] | 1 | [] | [] | 0 | 0 | null | [
"Rugamonas brunnea",
"Schizophora"
] | [
1,
125
] | 2 | [
"Drosophila melanogaster"
] | [
7
] | 1 | true | Domain | DEC-1 protein, N-terminal | DEC-1 protein, N-terminal | DEC-1_N | 4 |
IPR006720 | 6,720 | Dec-1 protein, C-terminal | DEC-1_C | Domain | 69 | false | false | The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing [ ]. Cleavage products include S80 (80kDa) which is incorporated into the eggshell, and further ... | [
"GO:0005213",
"GO:0007304",
"GO:0005576",
"GO:0042600"
] | [
"structural constituent of egg chorion",
"chorion-containing eggshell formation",
"extracellular region",
"egg chorion"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PFAM"
] | [
"PF04626"
] | [
"DEC-1_C"
] | [
69
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008509"
] | [
"1699826"
] | [
"Multiple proteins are produced from the dec-1 eggshell gene in Drosophila by alternative RNA splicing and proteolytic cleavage events."
] | [
1990
] | 1 | [] | [] | 0 | 0 | null | [
"Paenibacillus terrae (strain HPL-003)",
"Schizophora"
] | [
1,
68
] | 2 | [
"Drosophila melanogaster"
] | [
7
] | 1 | true | Domain | Dec-1 protein, C-terminal | Dec-1 protein, C-terminal | DEC-1_C | 6 |
IPR006721 | 6,721 | ATP synthase, F1 complex, epsilon subunit, mitochondrial | ATP_synth_F1_esu_mt | Family | 3,860 | false | false | Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ... | [
"GO:0046933",
"GO:0015986",
"GO:0005743"
] | [
"proton-transporting ATP synthase activity, rotational mechanism",
"proton motive force-driven ATP synthesis",
"mitochondrial inner membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER",
"CDD"
] | [
"PF04627",
"PTHR12448",
"cd12153"
] | [
"ATP-synt_Eps",
"",
"F1-ATPase_epsilon"
] | [
3853,
3174,
3696
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-163210",
"R-BTA-8949613",
"R-DME-163210",
"R-DME-8949613",
"R-HSA-163210",
"R-HSA-8949613",
"R-MMU-163210",
"R-MMU-8949613",
"R-RNO-163210",
"R-RNO-8949613"
] | [
"REACTOME:R-BTA-163210",
"REACTOME:R-BTA-8949613",
"REACTOME:R-DME-163210",
"REACTOME:R-DME-8949613",
"REACTOME:R-HSA-163210",
"REACTOME:R-HSA-8949613",
"REACTOME:R-MMU-163210",
"REACTOME:R-MMU-8949613",
"REACTOME:R-RNO-163210",
"REACTOME:R-RNO-8949613"
] | 10 | [
"1e79",
"1h8e",
"2ck3",
"2hld",
"2jdi",
"2v7q",
"2w6h",
"2w6i",
"2w6j",
"2wpd",
"2wss",
"2xnd",
"2xok",
"3fks",
"3oe7",
"3oee",
"3oeh",
"3ofn",
"3zia",
"3zry",
"4asu",
"4b2q",
"4yxw",
"5ara",
"5are",
"5arh",
"5ari",
"5fij",
"5fik",
"5fil",
"5lqx",
"5lqy"... | 174 | [
"PUB00009752",
"PUB00020603",
"PUB00020604",
"PUB00020605",
"PUB00068786",
"PUB00068787",
"PUB00068788",
"PUB00068789",
"PUB00082577",
"PUB00082578"
] | [
"11309608",
"15473999",
"15078220",
"16154570",
"20450191",
"18937357",
"1385979",
"9741106",
"19672878",
"15133470"
] | [
"Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.",
"The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.",
"Mechanisms of ATPases--a multi-disciplinary approach.",
"Regulation of the F0F1-ATP ... | [
2001,
2004,
2004,
2005,
2010,
2008,
1992,
1998,
2009,
2004
] | 10 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Solihabitans fulvus"
] | [
3859,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
3,
1,
2,
2,
3,
1,
4,
4,
1,
1,
12
] | 12 | true | Family | ATP synthase, F1 complex, epsilon subunit, mitochondrial | ATP synthase, F1 complex, epsilon subunit, mitochondrial | ATP_synth_F1_esu_mt | 8 |
IPR006722 | 6,722 | Trafficking protein particle complex subunit 2 | Sedlin | Family | 8,793 | false | false | Trafficking protein particle complex subunit 2, also known as Sedlin, is a 140 amino-acid protein with a putative role in endoplasmic reticulum-to-Golgi transport [ ]. Several missense mutations and deletion mutations in the SEDL gene, which result in protein truncation by frame shift, are responsible for spondyloepiph... | [
"GO:0006888"
] | [
"endoplasmic reticulum to Golgi vesicle-mediated transport"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF04628",
"PTHR12403"
] | [
"Sedlin_N",
""
] | [
8790,
8320
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-204005",
"R-BTA-8876198",
"R-CEL-204005",
"R-CEL-8876198",
"R-CFA-204005",
"R-CFA-8876198",
"R-DDI-204005",
"R-DDI-8876198",
"R-DME-204005",
"R-DME-8876198",
"R-DRE-204005",
"R-GGA-204005",
"R-HSA-204005",
"R-HSA-8876198",
"R-MMU-204005",
"R-MMU-8876198",
"R-RNO-204005",
"R-... | [
"REACTOME:R-BTA-204005",
"REACTOME:R-BTA-8876198",
"REACTOME:R-CEL-204005",
"REACTOME:R-CEL-8876198",
"REACTOME:R-CFA-204005",
"REACTOME:R-CFA-8876198",
"REACTOME:R-DDI-204005",
"REACTOME:R-DDI-8876198",
"REACTOME:R-DME-204005",
"REACTOME:R-DME-8876198",
"REACTOME:R-DRE-204005",
"REACTOME:R-GG... | 24 | [
"1h3q",
"2j3w",
"3pr6",
"7b6d",
"7b6r",
"7b6x",
"7b70",
"7e2c",
"7e2d",
"7e8s",
"7e8t",
"7e93",
"7e94",
"7ea3",
"7kmt",
"7u05",
"7u06"
] | 17 | [
"PUB00008512",
"PUB00074299"
] | [
"11349230",
"20498720"
] | [
"The molecular basis of X-linked spondyloepiphyseal dysplasia tarda.",
"SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1."
] | [
2001,
2010
] | 2 | [] | [
"IPR044760"
] | 0 | 1 | 0 | [
"Eukaryota"
] | [
8793
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
2,
3,
4,
13,
5,
2,
10,
14,
2,
2,
20
] | 12 | true | Family | Trafficking protein particle complex subunit 2 | Trafficking protein particle complex subunit 2 | Sedlin | 3 |
IPR006723 | 6,723 | Islet cell autoantigen Ica1, C-terminal | Islet_autoAg_Ica1_C | Domain | 2,510 | false | false | This entry represents a C-terminal domain found in islet cell autoantigen Ica1. Ica1 has been identified as an islet cell autoantigen in type I diabetes mellitus [ ]. Its precise function is unknown, though it may play a role in neurotransmitter secretion [ ]. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF04629",
"SM01237"
] | [
"ICA69",
"ICA69"
] | [
2433,
2377
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008513",
"PUB00055450"
] | [
"8975715",
"11029035"
] | [
"Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity.",
"The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion."
] | [
1996,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2510
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
55,
1,
7,
6,
14
] | 5 | true | Domain | Islet cell autoantigen Ica1, C-terminal | Islet cell autoantigen Ica1, C-terminal | Islet_autoAg_Ica1_C | 4 |
IPR006724 | 6,724 | Phage tail tube protein 1 | Phage_TTP | Family | 1,229 | false | false | This is a family of phage tail tube proteins from virus [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04630"
] | [
"Phage_TTP_1"
] | [
1229
] | 1 | [
"GP"
] | [
"GenProp0208"
] | [
"GP:GenProp0208"
] | 1 | [] | 0 | [
"PUB00075454"
] | [
"23542344"
] | [
"A conserved spiral structure for highly diverged phage tail assembly chaperones."
] | [
2013
] | 1 | [
"IPR006490"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Mus musculus",
"Viruses",
"metagenomes"
] | [
988,
1,
238,
2
] | 4 | [
"Mus musculus"
] | [
1
] | 1 | true | Family | Phage tail tube protein 1 | Phage tail tube protein 1 | Phage_TTP | 8 |
IPR006725 | 6,725 | Per os infectivity factor 2 | PIF2 | Family | 331 | false | false | This family includes several baculoviral proteins, with predicted molecular weights of approximately 44kDa. The per os infectivity factor 2 (PIF2) is included in this entry. PIF2 forms a stable complex with PIF1, PIF3, PIF4 which is essential for oral infectivity of Autographa californica multinucleocapsid nucleopolyhe... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04631"
] | [
"PIF2"
] | [
331
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00082562"
] | [
"20610731"
] | [
"Baculovirus per os infectivity factors form a complex on the surface of occlusion-derived virus."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Arthropoda",
"Lefavirales"
] | [
44,
287
] | 2 | [] | [] | 0 | true | Family | Per os infectivity factor 2 | Per os infectivity factor 2 | PIF2 | 6 |
IPR006726 | 6,726 | Para-hydroxybenzoic acid efflux pump subunit AaeB/fusaric acid resistance protein | PHBA_efflux_AaeB/fusaric-R | Family | 14,024 | false | false | This entry represents the p-hydroxybenzoic acid efflux pump subunit AaeB (pHBA efflux pump protein B) whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. It could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high level... | [
"GO:0022857",
"GO:0055085",
"GO:0005886"
] | [
"transmembrane transporter activity",
"transmembrane transport",
"plasma membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF04632"
] | [
"FUSC"
] | [
14024
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008514",
"PUB00054183"
] | [
"1370369",
"15489430"
] | [
"Molecular cloning and characterization of the fusaric acid-resistance gene from Pseudomonas cepacia.",
"Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve?"
] | [
1991,
2004
] | 2 | [] | [
"IPR023706"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacterium congolense",
"unclassified sequences"
] | [
13773,
219,
1,
31
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
2,
4
] | 2 | true | Family | Para-hydroxybenzoic acid efflux pump subunit AaeB/fusaric acid resistance protein | Para-hydroxybenzoic acid efflux pump subunit AaeB/fusaric acid resistance protein | PHBA_efflux_AaeB/fusaric-R | 6 |
IPR006727 | 6,727 | Herpesvirus BMRF2 protein | Herpes_BMRF2 | Family | 90 | false | false | This is a family of unknown function found in the Herpes viruses. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04633"
] | [
"Herpes_BMRF2"
] | [
90
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Orthoherpesviridae"
] | [
90
] | 1 | [] | [] | 0 | true | Family | Herpesvirus BMRF2 protein | Herpesvirus BMRF2 protein | Herpes_BMRF2 | 5 |
IPR006728 | 6,728 | Immunity protein YezG-like | YezG-like | Family | 1,333 | false | false | Proteins in this entry include the Immunity protein YezG from Bacillus subtilis and Type VII secretion system protein EsaG from Staphylococcus aureus. YezG is the antitoxin component of a LXG toxin-antitoxin (TA) module that promote kin selection, mediate competition in biofilms, and drive spatial segregation of differ... | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF04634",
"TIGR01741"
] | [
"YezG-like",
"staph_tand_hypo"
] | [
1333,
828
] | 2 | [] | [] | [] | 0 | [
"2ia1",
"3i0t",
"8guo",
"8gup"
] | 4 | [
"PUB00070721",
"PUB00093667",
"PUB00101092"
] | [
"22200572",
"27723728",
"34280190"
] | [
"A novel family of toxin/antitoxin proteins in Bacillus species.",
"The type VII secretion system of Staphylococcus aureus secretes a nuclease toxin that targets competitor bacteria.",
"Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms."
] | [
2012,
2016,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"human gut metagenome"
] | [
1328,
4,
1
] | 3 | [] | [] | 0 | true | Family | Immunity protein YezG-like | Immunity protein YezG-like | YezG-like | 9 |
IPR006730 | 6,730 | Sestrin | Sestrin | Family | 5,332 | false | false | Sestrins (Sesns) are involved in ROS (reactive oxygen species) regulation. In mammals, there are three Sestrins (Sesn1, Sesn2, and Sesn3), while in Drosophila melanogaster and C. elegans, there is only one Sesn [ ]. The N-terminal of Sesns shares protein sequence and structural similarity with the C-terminal α-helical ... | [
"GO:1901031",
"GO:0005634"
] | [
"regulation of response to reactive oxygen species",
"nucleus"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF04636",
"PTHR12474"
] | [
"PA26",
""
] | [
5320,
5307
] | 2 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.11.1.-",
"PWY-5292",
"R-BTA-5628897",
"R-BTA-9639288",
"R-BTA-9755511",
"R-CEL-5628897",
"R-CEL-9755511",
"R-DDI-5628897",
"R-DDI-9639288",
"R-DDI-9755511",
"R-DME-5628897",
"R-DME-9755511",
"R-HSA-5628897",
"R-HSA-9639288",
"R-HSA-9755511",
"R-MMU-5628897",
"R-MMU-9639288",
"R-... | [
"EC:1.11.1.-",
"METACYC:PWY-5292",
"REACTOME:R-BTA-5628897",
"REACTOME:R-BTA-9639288",
"REACTOME:R-BTA-9755511",
"REACTOME:R-CEL-5628897",
"REACTOME:R-CEL-9755511",
"REACTOME:R-DDI-5628897",
"REACTOME:R-DDI-9639288",
"REACTOME:R-DDI-9755511",
"REACTOME:R-DME-5628897",
"REACTOME:R-DME-9755511",... | 18 | [
"5cuf",
"5dj4",
"5t0n",
"6n0m",
"9lvj",
"9lwf"
] | 6 | [
"PUB00026775",
"PUB00070250",
"PUB00070251",
"PUB00070252"
] | [
"11799204",
"20712410",
"7938006",
"12203114"
] | [
"Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.",
"Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling.",
"Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes.",
"Identifica... | [
2002,
2011,
1994,
2002
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Ketogulonicigenium",
"marine metagenome"
] | [
5329,
2,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
2,
7,
13,
11
] | 6 | true | Family | Sestrin | Sestrin | Sestrin | 3 |
IPR006731 | 6,731 | Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) | Herpes_pp85 | Family | 232 | false | false | This family includes UL25 proteins from human cytomelagovirus (HCMV), as well as U14 proteins from the human herpesviruses HHV-6 and HHV-7. These 85kDa phosphoproteins appear to act as structural antigens, but their precise function is otherwise unknown. This entry also includes protein M35 from Murid herpesvirus 1. M3... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04637"
] | [
"Herpes_pp85"
] | [
232
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9609690",
"R-HSA-9610379"
] | [
"REACTOME:R-HSA-9609690",
"REACTOME:R-HSA-9610379"
] | 2 | [
"5b1q",
"8btj"
] | 2 | [
"PUB00088048"
] | [
"28542326"
] | [
"The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Herpesvirales",
"Opisthokonta"
] | [
228,
4
] | 2 | [
"Homo sapiens"
] | [
1
] | 1 | true | Family | Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) | Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) | Herpes_pp85 | 3 |
IPR006732 | 6,732 | Poxvirus O1 | Poxvirus_O1 | Family | 188 | false | false | This entry represents Protein O1 found in poxvirus. This protein is also known as Protein OPG074. It seems to be involved in binding to the host receptors. It comprises an N-terminal annular (ring) and a C-terminal globular (head) domains [ ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF015980"
] | [
"VAC_O1L"
] | [
188
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00103580"
] | [
"36680170"
] | [
"Phylogenomic and Structural Analysis of the Monkeypox Virus Shows Evolution towards Increased Stability."
] | [
2022
] | 1 | [
"IPR021155"
] | [] | 1 | 0 | 1 | [
"Poxviridae"
] | [
188
] | 1 | [] | [] | 0 | true | Family | Poxvirus O1 | Poxvirus O1 | Poxvirus_O1 | 1 |
IPR006734 | 6,734 | PLATZ transcription factor | PLATZ | Family | 7,489 | false | false | This family represents plant AT-rich sequence and zinc-binding proteins (PLATZ), which are zinc dependent DNA binding proteins. They bind to AT rich sequences and functions in transcriptional repression [ ]. Included in this family is the protein RGF1 INDUCIBLE TRANSCRIPTION FACTOR 1 (RITF1), a transcription factor tha... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04640"
] | [
"PLATZ"
] | [
7489
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00045078",
"PUB00096638"
] | [
"11600698",
"31801996"
] | [
"A novel class of plant-specific zinc-dependent DNA-binding protein that binds to A/T-rich DNA sequences.",
"RGF1 controls root meristem size through ROS signalling."
] | [
2001,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7489
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
58,
45,
52
] | 3 | true | Family | PLATZ transcription factor | PLATZ transcription factor | PLATZ | 9 |
IPR006735 | 6,735 | Replication termination factor 2 | Rtf2 | Family | 4,611 | false | false | This entry represents Replication termination factor 2 from Schizosaccharomyces pombe (Rtf2) and similar eukaryotic proteins [ ]. The site-specific replication barrier RTS1 terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass throug... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12775"
] | [
""
] | [
4611
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00066779",
"PUB00153784",
"PUB00153785",
"PUB00153786"
] | [
"19416828",
"37615341",
"29290612",
"32839439"
] | [
"Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart.",
"<i>Schizosaccharomyces pombe</i> Rtf2 is important for replication fork barrier activity of <i>RTS1</i> via splicing of <i>Rtf1</i>.",
"Removal of RTF2 from Stalled Replisomes Promotes Maintenanc... | [
2009,
2023,
2018,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4611
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
4,
1,
2,
1,
7,
6,
1,
3,
3,
1,
2
] | 11 | true | Family | Replication termination factor 2 | Replication termination factor 2 | Rtf2 | 6 |
IPR006736 | 6,736 | Protein of unknown function DUF601 | DUF601 | Family | 89 | false | false | This family consists of several uncharacterised plant proteins which share a conserved region. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04642"
] | [
"DUF601"
] | [
89
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Camelineae"
] | [
89
] | 1 | [
"Arabidopsis thaliana"
] | [
25
] | 1 | true | Family | Protein of unknown function DUF601 | Protein of unknown function DUF601 | DUF601 | 1 |
IPR006737 | 6,737 | Motilin/ghrelin-associated peptide | Motilin_assoc | Domain | 1,045 | false | false | Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. It is released into the general circulation at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions. Motilin also stim... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF04643"
] | [
"Motilin_assoc"
] | [
1045
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-416476",
"R-BTA-422085",
"R-CFA-416476",
"R-CFA-422085",
"R-HSA-375276",
"R-HSA-416476",
"R-HSA-422085",
"R-MMU-416476",
"R-MMU-422085",
"R-RNO-416476",
"R-RNO-422085",
"R-SSC-416476",
"R-SSC-422085"
] | [
"REACTOME:R-BTA-416476",
"REACTOME:R-BTA-422085",
"REACTOME:R-CFA-416476",
"REACTOME:R-CFA-422085",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-422085",
"REACTOME:R-MMU-416476",
"REACTOME:R-MMU-422085",
"REACTOME:R-RNO-416476",
"REACTOME:R-RNO-422085",
"REACTOME:R-SSC-416... | 13 | [
"2jsh",
"2jsj"
] | 2 | [
"PUB00007825",
"PUB00008516"
] | [
"11306336",
"9210180"
] | [
"Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.",
"Motilin and clinical application."
] | [
2001,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1045
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
4,
3
] | 4 | true | Domain | Motilin/ghrelin-associated peptide | Motilin/ghrelin-associated peptide | Motilin_assoc | 7 |
IPR006738 | 6,738 | Motilin/ghrelin | Motilin_ghrelin | Domain | 953 | false | false | Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. It is released into the general circulation at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions. Motilin also stim... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF04644"
] | [
"Motilin_ghrelin"
] | [
953
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-416476",
"R-BTA-422085",
"R-CFA-416476",
"R-CFA-422085",
"R-HSA-375276",
"R-HSA-416476",
"R-HSA-422085",
"R-MMU-416476",
"R-MMU-422085",
"R-RNO-416476",
"R-RNO-422085",
"R-SSC-416476",
"R-SSC-422085"
] | [
"REACTOME:R-BTA-416476",
"REACTOME:R-BTA-422085",
"REACTOME:R-CFA-416476",
"REACTOME:R-CFA-422085",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-422085",
"REACTOME:R-MMU-416476",
"REACTOME:R-MMU-422085",
"REACTOME:R-RNO-416476",
"REACTOME:R-RNO-422085",
"REACTOME:R-SSC-416... | 13 | [
"1lbj",
"6h3e",
"7f9y",
"7w2z",
"8ibv"
] | 5 | [
"PUB00007825",
"PUB00008516"
] | [
"11306336",
"9210180"
] | [
"Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.",
"Motilin and clinical application."
] | [
2001,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Amniota"
] | [
953
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
3
] | 3 | true | Domain | Motilin/ghrelin | Motilin/ghrelin | Motilin_ghrelin | 5 |
IPR006739 | 6,739 | Protein of unknown function DUF603 | DUF603 | Family | 303 | false | false | This family includes several uncharacterised proteins from Borrelia species. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04645"
] | [
"DUF603"
] | [
303
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Borreliaceae",
"Tanacetum cinerariifolium"
] | [
302,
1
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF603 | Protein of unknown function DUF603 | DUF603 | 8 |
IPR006740 | 6,740 | Protein of unknown function DUF604 | DUF604 | Family | 7,282 | false | false | This family includes a conserved region found in several uncharacterised plant proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04646"
] | [
"DUF604"
] | [
7282
] | 1 | [] | [] | [] | 0 | [
"8yrl"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7282
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
74,
1,
35,
32
] | 4 | true | Family | Protein of unknown function DUF604 | Protein of unknown function DUF604 | DUF604 | 9 |
IPR006741 | 6,741 | Accessory gene regulator B | AgrB | Family | 3,026 | false | false | This entry represents the accessory gene regulator protein B (AgrB) family. Proteins in this family include AgrB from Staphylococcus aureus and FsrB from Enterococcus faecalis. A cysteine peptidase is a proteolytic enzyme that hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile. Hydro... | [
"GO:0008233",
"GO:0009372",
"GO:0016020"
] | [
"peptidase activity",
"quorum sensing",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM",
"SMART"
] | [
"MF_00784",
"PF04647",
"SM00793"
] | [
"AgrB",
"AgrB",
"AgrB"
] | [
387,
3026,
2635
] | 3 | [
"GP"
] | [
"GenProp1011"
] | [
"GP:GenProp1011"
] | 1 | [] | 0 | [
"PUB00007991",
"PUB00008519",
"PUB00011704",
"PUB00020025",
"PUB00030423",
"PUB00070800",
"PUB00076953"
] | [
"12122003",
"11195102",
"11517925",
"9891971",
"14725770",
"10768947",
"7044372"
] | [
"Transmembrane topology of AgrB, the protein involved in the post-translational modification of AgrD in Staphylococcus aureus.",
"Inducible expression and cellular location of AgrB, a protein involved in the maturation of the staphylococcal quorum-sensing pheromone.",
"Evolutionary lines of cysteine peptidases.... | [
2002,
2000,
2001,
1998,
2004,
2000,
1982
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"metagenomes"
] | [
2984,
12,
30
] | 3 | [] | [] | 0 | true | Family | Accessory gene regulator B | Accessory gene regulator B | AgrB | 6 |
IPR006742 | 6,742 | Mating factor alpha, C-terminal repeat | Mating_factor_alpha_C | Repeat | 130 | false | false | This repeated sequence,WHWLQLKPGQPMY, characterises the mating factor alpha-1 or alpha-1 mating pheromone. The hormone is excreted into the culture medium by haploid cells of the alpha mating type and acts on cells of the opposite mating type (type A) by binding to a cognate G-protein coupled receptor which is coupled ... | [
"GO:0000772",
"GO:0019953",
"GO:0005576"
] | [
"mating pheromone activity",
"sexual reproduction",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF04648"
] | [
"MF_alpha"
] | [
130
] | 1 | [] | [] | [] | 0 | [
"7ad3",
"7aft",
"7qbc",
"7qbi"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Saccharomycotina"
] | [
2,
128
] | 2 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2
] | 1 | true | Repeat | Mating factor alpha, C-terminal repeat | Mating factor alpha, C-terminal repeat | Mating_factor_alpha_C | 2 |
IPR006744 | 6,744 | Poxvirus A12 | Poxvirus_A12 | Family | 216 | false | false | This family represents Protein A12 from Vaccinia virus, also known as 25 kDa core protein OPG138, and similar proteins from poxvirus. A12 is a component of the virion core that undergoes proteolytic processing during the immature virion (IV) to mature virion (MV) transition. It is essential for the formation of a struc... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04651"
] | [
"Pox_A12"
] | [
216
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00103581"
] | [
"17625005"
] | [
"Vaccinia virus A12L protein and its AG/A proteolysis play an important role in viral morphogenic transition."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
216
] | 1 | [] | [] | 0 | true | Family | Poxvirus A12 | Poxvirus A12 | Poxvirus_A12 | 6 |
IPR006746 | 6,746 | 26S proteasome non-ATPase regulatory subunit Rpn12 | 26S_Psome_Rpn12 | Family | 4,482 | false | false | Intracellular proteins, including short-lived proteins such as cyclin, Mos, Myc, p53, NF-kappaB, and IkappaB, are degraded by the ubiquitin-proteasome system. The 26S proteasome is a self-compartmentalising protease responsible for the regulated degradation of intracellular proteins in eukaryotes [ , ]. This giant intr... | [
"GO:0006508",
"GO:0005838"
] | [
"proteolysis",
"proteasome regulatory particle"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PANTHER"
] | [
"PTHR12387"
] | [
""
] | [
4482
] | 1 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp2012",
"R-CEL-1234176",
"R-CEL-1236978",
"R-CEL-187577",
"R-CEL-195253",
"R-CEL-349425",
"R-CEL-350562",
"R-CEL-382556",
"R-CEL-4608870",
"R-CEL-4641258",
"R-CEL-5632684",
"R-CEL-5687128",
"R-CEL-5689603",
"R-CEL-5689880",
"R-CEL-68949",
"R-CEL-69017",
"R-CEL-69601",
"R-CEL... | [
"GP:GenProp2012",
"REACTOME:R-CEL-1234176",
"REACTOME:R-CEL-1236978",
"REACTOME:R-CEL-187577",
"REACTOME:R-CEL-195253",
"REACTOME:R-CEL-349425",
"REACTOME:R-CEL-350562",
"REACTOME:R-CEL-382556",
"REACTOME:R-CEL-4608870",
"REACTOME:R-CEL-4641258",
"REACTOME:R-CEL-5632684",
"REACTOME:R-CEL-56871... | 191 | [
"3jck",
"3jco",
"3jcp",
"4b0z",
"4cr2",
"4cr3",
"4cr4",
"5a5b",
"5gjq",
"5gjr",
"5l4k",
"5ln3",
"5m32",
"5mpb",
"5mpc",
"5mpd",
"5mpe",
"5t0c",
"5t0g",
"5t0h",
"5t0i",
"5t0j",
"5vfp",
"5vfq",
"5vfr",
"5vfs",
"5vft",
"5vfu",
"5vgz",
"5vhf",
"5vhh",
"5vhi"... | 111 | [
"PUB00016866",
"PUB00020294",
"PUB00034667",
"PUB00034668",
"PUB00034669",
"PUB00043308",
"PUB00086026"
] | [
"15571806",
"8621436",
"15890341",
"9741626",
"7621825",
"16566573",
"28583440"
] | [
"The proteasome: a proteolytic nanomachine of cell regulation and waste disposal.",
"A conditional lethal mutant in the fission yeast 26 S protease subunit mts3+ is defective in metaphase to anaphase transition.",
"Proteasome plasticity.",
"A subcomplex of the proteasome regulatory particle required for ubiqu... | [
2004,
1996,
2005,
1998,
1995,
2006,
2017
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Hyperionvirus sp."
] | [
4481,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
2,
2,
13,
9,
1,
2,
6,
1,
1,
10
] | 12 | true | Family | 26S proteasome non-ATPase regulatory subunit Rpn12 | 26S proteasome non-ATPase regulatory subunit Rpn12 | 26S_Psome_Rpn12 | 3 |
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