interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR001195 | 1,195 | Glycophorin | Glycophorin | Family | 343 | false | false | Proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates attached to lipids or proteins [Reid M.E., Lomas-Francis C. The Blood Group Antigen FactsBook Academic... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF002466",
"PTHR13813"
] | [
"Glycophorin",
""
] | [
108,
338
] | 2 | [
"PROSITEDOC",
"REACTOME"
] | [
"PDOC00281",
"R-HSA-202733"
] | [
"PROSITEDOC:PDOC00281",
"REACTOME:R-HSA-202733"
] | 2 | [
"1afo",
"2kpe",
"2kpf",
"5eh4",
"5eh6",
"7uz3",
"7v07",
"7v0k",
"7v19",
"8crq",
"8crr",
"8crt",
"8cs9",
"8csl",
"8ct3",
"8cte"
] | 16 | [
"PUB00000593"
] | [
"2605264"
] | [
"Amino acid sequence of monkey erythrocyte glycophorin MK. Its amino acid sequence has a striking homology with that of human glycophorin A."
] | [
1989
] | 1 | [] | [
"IPR049535"
] | 0 | 1 | 0 | [
"Theria"
] | [
343
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
76,
4,
2
] | 3 | true | Family | Glycophorin | Glycophorin | Glycophorin | 6 |
IPR001196 | 1,196 | Large ribosomal subunit protein uL15, conserved site | Ribosomal_uL15_CS | Conserved_site | 27,265 | false | false | This entry represents a conserved region in the C-terminal section of the large ribosomal subunit protein uL15, which is found in al cellular organisms. Large ribosomal subunit protein uL15 was previously known as L15. In Escherichia coli, L15 is known to bind the 23S rRNA. Ribosomal protein, L15 from bacteria and plan... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS00475"
] | [
"RIBOSOMAL_L15"
] | [
27265
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00386",
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72689",
"R-BTA-72706",
"R-BTA-9629569",
"R-BTA-975956",
"R-BTA-975957",
"R-DDI-156827",
"R-DDI-1799339",
"R-DDI-72689",
"R-DDI-72706",
"R-DDI-975956",
"R-DDI-975957",
"R-DME-156827",
"R-DME-1799339",
"R-DME-72689... | [
"PROSITEDOC:PDOC00386",
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-9629569",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-DDI-156827",
"REACTOME:R-DDI-1799339",
"REACTOME:R-DDI-72... | 63 | [
"1ffk",
"1jj2",
"1k73",
"1k8a",
"1k9m",
"1kc8",
"1kd1",
"1kqs",
"1m1k",
"1m90",
"1ml5",
"1n8r",
"1nji",
"1nkw",
"1nwx",
"1nwy",
"1q7y",
"1q81",
"1q82",
"1q86",
"1qvf",
"1qvg",
"1s72",
"1sm1",
"1vq4",
"1vq5",
"1vq6",
"1vq7",
"1vq8",
"1vq9",
"1vqk",
"1vql"... | 1,762 | [
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00010656",
"PUB00080279"
] | [
"11297922",
"11290319",
"11114498",
"10527834",
"24524803"
] | [
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins.",
"Cloning, sequencing, and characterization of ribosomal protein and RNA polymerase genes from the region analogous to the alpha-operon of escherichia coli in hal... | [
2001,
2001,
2000,
1999,
2014
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1434,
19421,
6016,
394
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
7,
2,
1,
2,
2,
4,
1,
1,
10,
8,
1,
2,
11
] | 13 | true | Conserved_site | Large ribosomal subunit protein uL15, conserved site | Large ribosomal subunit protein uL15, conserved site | Ribosomal_uL15_CS | 1 |
IPR001197 | 1,197 | Large ribosomal subunit protein uL16, eukaryota/archaea | Ribosomal_uL16_euk_arch | Family | 8,836 | false | false | This family consists of large ribosomal subunit protein uL16 from archaea and eukaryotes (in the latter were previously known as L10) [ , ]. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PIRSF005590",
"PTHR11726",
"TIGR00279"
] | [
"Ribosomal_L10",
"",
"uL16_euk_arch"
] | [
5631,
8810,
4956
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00968",
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72689",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-72689",
"R-CEL-72706",
"R-CEL-975956",
"R-CEL-975957",
"R-DDI-156827",
"R-DDI-1799339",
"R-DDI-72689",
"R-DDI-72706",... | [
"PROSITEDOC:PDOC00968",
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-1799339",
"REACTOME:R-CEL-72689",
"REACTOME:R-CEL-7270... | 77 | [
"1ffk",
"1jj2",
"1k73",
"1k8a",
"1k9m",
"1kc8",
"1kd1",
"1kqs",
"1m1k",
"1m90",
"1ml5",
"1n8r",
"1nji",
"1q7y",
"1q81",
"1q82",
"1q86",
"1qvf",
"1qvg",
"1s72",
"1vq4",
"1vq5",
"1vq6",
"1vq7",
"1vq8",
"1vq9",
"1vqk",
"1vql",
"1vqm",
"1vqn",
"1vqo",
"1vqp"... | 570 | [
"PUB00000257",
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00080279"
] | [
"8780716",
"11297922",
"11290319",
"11114498",
"24524803"
] | [
"The primary structure of rat ribosomal protein L10: relationship to a Jun-binding protein and to a putative Wilms' tumor suppressor.",
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins.",
"A new system for namin... | [
1996,
2001,
2001,
2000,
2014
] | 5 | [
"IPR047873"
] | [
"IPR022981"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Picornavirales sp.",
"unclassified sequences"
] | [
909,
9,
7871,
1,
46
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
1,
2,
2,
11,
8,
1,
8,
6,
1,
2,
20
] | 12 | true | Family | Large ribosomal subunit protein uL16, eukaryota/archaea | Large ribosomal subunit protein uL16, eukaryota/archaea | Ribosomal_uL16_euk_arch | 3 |
IPR001199 | 1,199 | Cytochrome b5-like heme/steroid binding domain | Cyt_B5-like_heme/steroid-bd | Domain | 76,532 | false | false | Cytochrome b5 is a membrane-bound hemoprotein which acts as an electron carrier for several membrane-bound oxygenases [ ]. There are two homologous forms of b5, one found in microsomes and one found in the outer membrane of mitochondria. Two conserved histidine residues serve as axial ligands for the heme group. The st... | [] | [] | [] | 0 | [
"PFAM",
"PRINTS",
"PROFILE",
"SMART"
] | [
"PF00173",
"PR00363",
"PS50255",
"SM01117"
] | [
"Cyt-b5",
"CYTOCHROMEB5",
"CYTOCHROME_B5_2",
"Cyt-b5"
] | [
74846,
32023,
59021,
72565
] | 4 | [
"GP",
"GP",
"GP",
"GP",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"R... | [
"GenProp1423",
"GenProp1452",
"GenProp1554",
"GenProp1597",
"PDOC00170",
"R-BTA-1237044",
"R-BTA-196836",
"R-BTA-2046105",
"R-BTA-2046106",
"R-BTA-9609523",
"R-CEL-6798695",
"R-CEL-9013405",
"R-CEL-9707616",
"R-DME-1614517",
"R-DME-1660661",
"R-DME-196836",
"R-DME-211945",
"R-DME-5... | [
"GP:GenProp1423",
"GP:GenProp1452",
"GP:GenProp1554",
"GP:GenProp1597",
"PROSITEDOC:PDOC00170",
"REACTOME:R-BTA-1237044",
"REACTOME:R-BTA-196836",
"REACTOME:R-BTA-2046105",
"REACTOME:R-BTA-2046106",
"REACTOME:R-BTA-9609523",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-9013405",
"REACTOME:R-CEL... | 103 | [
"1aqa",
"1aw3",
"1awp",
"1axx",
"1b5a",
"1b5b",
"1b5m",
"1bfx",
"1blv",
"1cxy",
"1cyo",
"1do9",
"1ehb",
"1es1",
"1eue",
"1f03",
"1f04",
"1fcb",
"1hko",
"1i5u",
"1i87",
"1i8c",
"1ib7",
"1icc",
"1iet",
"1ieu",
"1j03",
"1j0q",
"1jex",
"1kbi",
"1lco",
"1ldc"... | 92 | [
"PUB00000592",
"PUB00001140",
"PUB00001335",
"PUB00004363",
"PUB00004659"
] | [
"2752049",
"3004948",
"510290",
"2549511",
"3393528"
] | [
"Structure of cytochrome b5 and its topology in the microsomal membrane.",
"Structure, expression and regulation of a nuclear gene encoding a mitochondrial protein: the yeast L(+)-lactate cytochrome c oxidoreductase (cytochrome b2).",
"Amino acid sequence of the 'b5-like' heme-binding domain from chicken sulfit... | [
1989,
1985,
1979,
1989,
1988
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviricetes",
"metagenomes"
] | [
108,
2189,
74043,
40,
152
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
55,
13,
26,
40,
41,
34,
20,
45,
71,
6,
6,
117
] | 12 | true | Domain | Cytochrome b5-like heme/steroid binding domain | Cytochrome b5-like heme/steroid binding domain | Cyt_B5-like_heme/steroid-bd | 4 |
IPR001200 | 1,200 | Phosducin | Phosducin | Family | 5,217 | false | false | The outer and inner segments of vertebrate rod photoreceptor cells contain phosducin, a soluble phosphoprotein that complexes with the beta/gamma-subunits of the GTP-binding protein, transducin. Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of phosducin by protein kinase A [ ]. The prot... | [
"GO:0008277"
] | [
"regulation of G protein-coupled receptor signaling pathway"
] | [
"biological_process"
] | 1 | [
"PRINTS",
"CDD"
] | [
"PR00677",
"cd02987"
] | [
"PHOSDUCIN",
"Phd_like_Phd"
] | [
4096,
5088
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6814122",
"R-DME-6814122",
"R-HSA-6814122",
"R-MMU-6814122",
"R-RNO-6814122"
] | [
"REACTOME:R-BTA-6814122",
"REACTOME:R-DME-6814122",
"REACTOME:R-HSA-6814122",
"REACTOME:R-MMU-6814122",
"REACTOME:R-RNO-6814122"
] | 5 | [
"1a0r",
"1b9x",
"1b9y",
"2trc",
"8sff",
"8sg8",
"8sgc",
"8sh9",
"8sha",
"8shf",
"8shg",
"8shl",
"8sho",
"8shp",
"8shq",
"8sht"
] | 16 | [
"PUB00001790",
"PUB00002577"
] | [
"2210381",
"2203790"
] | [
"Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland.",
"Amino acid and cDNA sequence of bovine phosducin, a soluble phosphoprotein from photoreceptor cells."
] | [
1990,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5217
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
4,
1,
3,
7,
1,
7
] | 7 | true | Family | Phosducin | Phosducin | Phosducin | 9 |
IPR001202 | 1,202 | WW domain | WW_dom | Domain | 136,492 | false | false | The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded β-sheet. This short domain of approximately 40 amino acids, may be repeated up to four times in some proteins [ , , , ]. The name WW or WWP derives from the presence of two signature tryptophan residues... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PFAM",
"PROSITE",
"PROFILE",
"SMART",
"CDD"
] | [
"PF00397",
"PF18507",
"PS01159",
"PS50020",
"SM00456",
"cd00201"
] | [
"WW",
"WW_1",
"WW_DOMAIN_1",
"WW_DOMAIN_2",
"WW",
"WW"
] | [
102399,
57,
97992,
132915,
117771,
120634
] | 6 | [
"GP",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp1754",
"PDOC50020",
"R-BTA-5668599",
"R-BTA-6804756",
"R-BTA-6811555",
"R-BTA-72163",
"R-BTA-936440",
"R-CEL-1251985",
"R-CEL-1253288",
"R-CEL-2028269",
"R-CEL-2032785",
"R-CEL-2173796",
"R-CEL-2672351",
"R-CEL-4641258",
"R-CEL-6798695",
"R-CEL-8939236",
"R-CEL-8948751",
"R... | [
"GP:GenProp1754",
"PROSITEDOC:PDOC50020",
"REACTOME:R-BTA-5668599",
"REACTOME:R-BTA-6804756",
"REACTOME:R-BTA-6811555",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-936440",
"REACTOME:R-CEL-1251985",
"REACTOME:R-CEL-1253288",
"REACTOME:R-CEL-2028269",
"REACTOME:R-CEL-2032785",
"REACTOME:R-CEL-21737... | 273 | [
"1e0l",
"1e0m",
"1e0n",
"1eg3",
"1eg4",
"1f8a",
"1i5h",
"1i6c",
"1i8g",
"1i8h",
"1jmq",
"1k5r",
"1k9q",
"1k9r",
"1nmv",
"1o6w",
"1pin",
"1tk7",
"1wmv",
"1wr3",
"1wr4",
"1wr7",
"1yiu",
"1ymz",
"1yw5",
"1ywi",
"1ywj",
"1zcn",
"1zr7",
"2djy",
"2dk1",
"2dk7"... | 321 | [
"PUB00000239",
"PUB00001680",
"PUB00001690",
"PUB00004872",
"PUB00005431",
"PUB00007124"
] | [
"7802651",
"7828727",
"7641887",
"7644498",
"7846762",
"11911877"
] | [
"WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3-binding Yes-associated protein YAP65.",
"The rsp5-domain is shared by proteins of diverse functions.",
"Characterization of a novel protein-binding module--the WW domain.",
"The WW domain of ... | [
1994,
1995,
1995,
1995,
1994,
2002
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
3,
1840,
134538,
34,
77
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
80,
40,
537,
72,
273,
205,
10,
38,
263,
6,
9,
194
] | 12 | true | Domain | WW domain | WW domain | WW_dom | 4 |
IPR001203 | 1,203 | Aldehyde ferredoxin oxidoreductase, C-terminal | OxRdtase_Ald_Fedxn_C | Domain | 6,062 | false | false | This entry represents the C-terminal region of the the aldehyde ferredoxin oxidoreductase (AOR) family enzymes, containing the α-helical structural domains 2 and 3 [ , ]. Enzymes of the aldehyde ferredoxin oxidoreductase (AOR) family [ ] contain a tungsten cofactor and an 4Fe4S cluster and catalyse the interconversion ... | [
"GO:0009055",
"GO:0016491",
"GO:0016625",
"GO:0051536"
] | [
"electron transfer activity",
"oxidoreductase activity",
"oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor",
"iron-sulfur cluster binding"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"molecular_function"
] | 4 | [
"PFAM"
] | [
"PF01314"
] | [
"AFOR_C"
] | [
6062
] | 1 | [] | [] | [] | 0 | [
"1aor",
"1b25",
"1b4n",
"4z3w",
"4z3x",
"4z3y",
"4z3z",
"4z40",
"6x1o",
"6x6u",
"8c0z",
"9g7j",
"9mqx"
] | 13 | [
"PUB00005196",
"PUB00007125",
"PUB00007126",
"PUB00007127",
"PUB00007128",
"PUB00007129",
"PUB00007130",
"PUB00021189"
] | [
"7878465",
"9242907",
"8672295",
"2550230",
"8026480",
"7721730",
"9275170",
"10024458"
] | [
"Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase.",
"Molybdenum-cofactor-containing enzymes: structure and mechanism.",
"Tungsten in biological systems.",
"Carboxylic acid reductase: a new tungsten enzyme catalyses the reduction of non-activated carboxylic acids to al... | [
1995,
1997,
1996,
1989,
1994,
1995,
1997,
1999
] | 8 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1860,
3506,
5,
691
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Aldehyde ferredoxin oxidoreductase, C-terminal | Aldehyde ferredoxin oxidoreductase, C-terminal | OxRdtase_Ald_Fedxn_C | 9 |
IPR001204 | 1,204 | Phosphate transporter | Phos_transporter | Family | 36,870 | false | false | The PHO-4 family of transporters includes the phosphate-repressible phosphate permease (PHO-4) from Neurospora crassa, which is probably a sodium-phosphate symporter [ ] and the Low-affinity inorganic phosphate transporter PitA from Escherichia coli, whose activity impacts bacterial growth in low Mg2+ conditions [ , ].... | [
"GO:0005315",
"GO:0006817",
"GO:0016020"
] | [
"phosphate transmembrane transporter activity",
"phosphate ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF01384",
"PTHR11101"
] | [
"PHO4",
""
] | [
36814,
36746
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-427652",
"R-HSA-427652",
"R-HSA-5619111",
"R-MMU-427652",
"R-RNO-427652",
"R-SCE-427652",
"R-XTR-427652"
] | [
"REACTOME:R-DRE-427652",
"REACTOME:R-HSA-427652",
"REACTOME:R-HSA-5619111",
"REACTOME:R-MMU-427652",
"REACTOME:R-RNO-427652",
"REACTOME:R-SCE-427652",
"REACTOME:R-XTR-427652"
] | 7 | [
"6l85"
] | 1 | [
"PUB00004860",
"PUB00101328",
"PUB00101329",
"PUB00101330",
"PUB00101331",
"PUB00151050"
] | [
"7732001",
"15955065",
"11435563",
"11489853",
"30276893",
"36346250"
] | [
"Repressible cation-phosphate symporters in Neurospora crassa.",
"Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2.",
"Id... | [
1995,
2005,
2001,
2001,
2019,
2022
] | 6 | [] | [
"IPR047818"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1994,
24713,
9752,
3,
408
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
5,
7,
13,
2,
2,
14,
4,
1,
4,
7,
1,
3
] | 12 | true | Family | Phosphate transporter | Phosphate transporter | Phos_transporter | 9 |
IPR001205 | 1,205 | RNA-directed RNA polymerase, C-terminal domain | RNA-dir_pol_C | Domain | 55,882 | false | false | This entry represents the C-terminal domain of the RNA-directed RNA polymerase (RdRp) found in many positive strand RNA eukaryotic viruses. It is part of the genome polyprotein that contains other polypeptides such as coat proteins VP1 to VP4, core proteins P2A to P2C and P3A, genome-linked protein VPG and picornain 3C... | [
"GO:0003723",
"GO:0003968",
"GO:0006351"
] | [
"RNA binding",
"RNA-directed RNA polymerase activity",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF00680"
] | [
"RdRP_1"
] | [
55882
] | 1 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7.48",
"3.4.22",
"R-HSA-191859",
"R-HSA-918233",
"R-HSA-9679504",
"R-HSA-9682706",
"R-HSA-9682708",
"R-HSA-9683439",
"R-HSA-9684325",
"R-HSA-9692916",
"R-HSA-9694271",
"R-HSA-9694301",
"R-HSA-9694676",
"R-HSA-9694686",
"R-HSA-9694786",
"R-HSA-9705671",
"R-HSA-9735869",
"R-HSA-... | [
"EC:2.7.7.48",
"EC:3.4.22",
"REACTOME:R-HSA-191859",
"REACTOME:R-HSA-918233",
"REACTOME:R-HSA-9679504",
"REACTOME:R-HSA-9682706",
"REACTOME:R-HSA-9682708",
"REACTOME:R-HSA-9683439",
"REACTOME:R-HSA-9684325",
"REACTOME:R-HSA-9692916",
"REACTOME:R-HSA-9694271",
"REACTOME:R-HSA-9694301",
"REACT... | 18 | [
"1hhs",
"1hht",
"1hi0",
"1hi1",
"1hi8",
"1khv",
"1khw",
"1ra6",
"1ra7",
"1raj",
"1rdr",
"1sh0",
"1sh2",
"1sh3",
"1tp7",
"1tql",
"1u09",
"1uvi",
"1uvj",
"1uvk",
"1uvl",
"1uvm",
"1uvn",
"1wac",
"1wne",
"1xr5",
"1xr6",
"1xr7",
"2b43",
"2ckw",
"2d7s",
"2e9r"... | 272 | [
"PUB00028057",
"PUB00028058",
"PUB00094093",
"PUB00098221",
"PUB00099876"
] | [
"15306852",
"15296746",
"31138817",
"32438371",
"34580920"
] | [
"Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase.",
"The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy.",
"Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp... | [
2004,
2004,
2019,
2020,
2021
] | 5 | [] | [] | 0 | 0 | null | [
"Chitinophaga agrisoli",
"Eukaryota",
"Viruses",
"organismal metagenomes"
] | [
1,
196,
55536,
149
] | 4 | [] | [] | 0 | true | Domain | RNA-directed RNA polymerase, C-terminal domain | RNA-directed RNA polymerase, C-terminal domain | RNA-dir_pol_C | 6 |
IPR001206 | 1,206 | Diacylglycerol kinase, catalytic domain | Diacylglycerol_kinase_cat_dom | Domain | 82,009 | false | false | The DAG-kinase catalytic domain or DAGKc domain is present in mammalian lipid kinases, such as diacylglycerol (DAG), ceramide and sphingosine kinases, as well as in related bacterial proteins [ , ]. Eukaryotic DAG-kinase ( ) catalyses the phosphorylation of DAG to phosphatidic acid, thus modulating the balance between ... | [
"GO:0016301"
] | [
"kinase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00781",
"PS50146",
"SM00046"
] | [
"DAGK_cat",
"DAGK",
"DAGKc"
] | [
81120,
80321,
69186
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REA... | [
"2.7.1",
"GenProp1277",
"GenProp1335",
"GenProp1363",
"R-BTA-114508",
"R-CEL-114508",
"R-CEL-1483206",
"R-CEL-1660661",
"R-CEL-390471",
"R-CEL-5218921",
"R-CEL-9009391",
"R-CEL-9833482",
"R-CEL-9840309",
"R-DDI-114508",
"R-DDI-1483206",
"R-DDI-1660661",
"R-DDI-390471",
"R-DDI-52189... | [
"EC:2.7.1",
"GP:GenProp1277",
"GP:GenProp1335",
"GP:GenProp1363",
"REACTOME:R-BTA-114508",
"REACTOME:R-CEL-114508",
"REACTOME:R-CEL-1483206",
"REACTOME:R-CEL-1660661",
"REACTOME:R-CEL-390471",
"REACTOME:R-CEL-5218921",
"REACTOME:R-CEL-9009391",
"REACTOME:R-CEL-9833482",
"REACTOME:R-CEL-98403... | 58 | [
"2bon",
"2jgr",
"2p1r",
"2qv7",
"2qvl",
"3s40",
"3t5p",
"3vzb",
"3vzc",
"3vzd",
"4l02",
"4v24",
"4wer",
"4wrr",
"7cgp"
] | 15 | [
"PUB00002985",
"PUB00039707",
"PUB00044045",
"PUB00052586"
] | [
"8626538",
"17351295",
"17512245",
"19112175"
] | [
"Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases.",
"Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site.",
... | [
1996,
2007,
2007,
2009
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Klosneuvirinae",
"unclassified sequences"
] | [
292,
38455,
42653,
3,
606
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
57,
19,
171,
35,
1,
71,
55,
3,
46,
77,
2,
1,
113
] | 13 | true | Domain | Diacylglycerol kinase, catalytic domain | Diacylglycerol kinase, catalytic domain | Diacylglycerol_kinase_cat_dom | 8 |
IPR001207 | 1,207 | Transposase, mutator type | Transposase_mutator | Family | 30,981 | false | false | Autonomous mobile genetic elements such as transposon or insertion sequences (IS) encode an enzyme, transposase, that is required for excising and inserting the mobile element. Transposases have been grouped into various families [ , , ]. The mutator family of transposases consists of a number of elements that include,... | [
"GO:0003677",
"GO:0004803",
"GO:0006313"
] | [
"DNA binding",
"transposase activity",
"DNA transposition"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM",
"PROSITE",
"PANTHER"
] | [
"PF00872",
"PS01007",
"PTHR33217"
] | [
"Transposase_mut",
"TRANSPOSASE_MUTATOR",
""
] | [
29130,
11260,
25118
] | 3 | [
"PROSITEDOC"
] | [
"PDOC00770"
] | [
"PROSITEDOC:PDOC00770"
] | 1 | [
"6xg8",
"6xgw",
"6xgx"
] | 3 | [
"PUB00001812",
"PUB00003820",
"PUB00004452"
] | [
"1718819",
"1310791",
"8041625"
] | [
"IS406 and IS407, two gene-activating insertion sequences for Pseudomonas cepacia.",
"Isolation and analysis of IS6120, a new insertion sequence from Mycobacterium smegmatis.",
"Sequence similarity of putative transposases links the maize Mutator autonomous element and a group of bacterial insertion sequences."... | [
1991,
1992,
1994
] | 3 | [] | [
"IPR048004"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
412,
27849,
2107,
12,
601
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
16,
26,
8
] | 3 | true | Family | Transposase, mutator type | Transposase, mutator type | Transposase_mutator | 6 |
IPR001208 | 1,208 | MCM domain | MCM_dom | Domain | 53,543 | false | false | Proteins shown to be required for the initiation of eukaryotic DNA replication share a highly conserved domain of about 210 amino-acid residues [ , , ]. The latter shows some similarities [ ] with that of various other families of DNA-dependent ATPases. Eukaryotes seem to possess a family of eight proteins that contain... | [
"GO:0003677",
"GO:0005524"
] | [
"DNA binding",
"ATP binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"PRINTS",
"PROFILE"
] | [
"PF00493",
"PR01657",
"PS50051"
] | [
"MCM",
"MCMFAMILY",
"MCM_2"
] | [
41664,
46180,
45024
] | 3 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.6.4.12",
"PDOC00662",
"R-BTA-176187",
"R-BTA-68689",
"R-BTA-68867",
"R-BTA-68949",
"R-BTA-68962",
"R-BTA-69052",
"R-CEL-68867",
"R-CEL-68949",
"R-CEL-68962",
"R-CEL-69052",
"R-DDI-68867",
"R-DDI-68962",
"R-DDI-69052",
"R-DME-176187",
"R-DME-68689",
"R-DME-68867",
"R-DME-68949"... | [
"EC:3.6.4.12",
"PROSITEDOC:PDOC00662",
"REACTOME:R-BTA-176187",
"REACTOME:R-BTA-68689",
"REACTOME:R-BTA-68867",
"REACTOME:R-BTA-68949",
"REACTOME:R-BTA-68962",
"REACTOME:R-BTA-69052",
"REACTOME:R-CEL-68867",
"REACTOME:R-CEL-68949",
"REACTOME:R-CEL-68962",
"REACTOME:R-CEL-69052",
"REACTOME:R-... | 58 | [
"3f8t",
"3f9v",
"3ja8",
"3jc5",
"3jc6",
"3jc7",
"4fdg",
"4r7y",
"4r7z",
"5bk4",
"5u8s",
"5u8t",
"5v8f",
"5xf8",
"6eyc",
"6f0l",
"6hv9",
"6mii",
"6ptj",
"6ptn",
"6pto",
"6raw",
"6rax",
"6ray",
"6raz",
"6rqc",
"6skl",
"6sko",
"6u0m",
"6wgc",
"6wgf",
"6wgg"... | 105 | [
"PUB00004410",
"PUB00004422",
"PUB00004436",
"PUB00005507",
"PUB00094697",
"PUB00094698"
] | [
"1454522",
"8332451",
"8265339",
"14731643",
"22771115",
"30743181"
] | [
"Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.",
"A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication.",
"The P1 family: a new cla... | [
1992,
1993,
1993,
1994,
2012,
2019
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1236,
11633,
40316,
17,
341
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
54,
6,
19,
17,
57,
30,
6,
15,
29,
6,
6,
126
] | 12 | true | Domain | MCM domain | MCM domain | MCM_dom | 4 |
IPR001209 | 1,209 | Small ribosomal subunit protein uS14 | Ribosomal_uS14 | Family | 49,710 | false | false | uS14 is one of the proteins from the small ribosomal subunit. In Escherichia coli, uS14 is known to be required for the assembly of 30S particles and may also be responsible for determining the conformation of 16S rRNA at the A site. It belongs to a family of ribosomal proteins [ ] that include bacterial, algal and pla... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF00253",
"PTHR19836"
] | [
"Ribosomal_S14",
""
] | [
49578,
44474
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00456",
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-6791226",
"R-BTA-72649",
"R-BTA-72689",
"R-BTA-72695",
"R-BTA-72702",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-BTA-9937383",
"R-CEL-5389840",
"R-CEL-5419276",
"R-CEL-9937383",
"R-DDI-156... | [
"PROSITEDOC:PDOC00456",
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-5389840",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72649",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72695",
"REACTOME:R-BTA-72702",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-97595... | 97 | [
"1fjg",
"1hnw",
"1hnx",
"1hnz",
"1hr0",
"1i94",
"1i95",
"1i96",
"1i97",
"1ibk",
"1ibl",
"1ibm",
"1j5e",
"1jgo",
"1jgp",
"1jgq",
"1ml5",
"1n32",
"1n33",
"1n34",
"1n36",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1xmo",
"1xmq",
"1xnq",
"1xnr",
"2e5l",
"2f4v"... | 1,816 | [
"PUB00004441",
"PUB00007068",
"PUB00007069",
"PUB00007070"
] | [
"8441676",
"11297922",
"11290319",
"11114498"
] | [
"Zinc finger-like motifs in rat ribosomal proteins S27 and S29.",
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins."
] | [
1993,
2001,
2001,
2000
] | 4 | [] | [
"IPR023036",
"IPR023053",
"IPR039744"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
889,
25912,
22567,
342
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
19,
2,
2,
7,
1,
6,
3,
2,
11,
8,
3,
2,
24
] | 13 | true | Family | Small ribosomal subunit protein uS14 | Small ribosomal subunit protein uS14 | Ribosomal_uS14 | 7 |
IPR001210 | 1,210 | Small ribosomal subunit protein eS17 | Ribosomal_eS17 | Family | 7,153 | false | false | A number of eukaryotic and archaebacterial ribosomal proteins can be grouped in this family of ribosomal proteins, eS17 (RPS17) [ ]. They include, vertebrate, Drosophila and Neurospora crassa (crp-3) eS17's as well as yeast eS17a (RP51A) and eS17b (RP51B) [ ] and archaebacterial eS17 [ , , ]. Ribosomes are the particle... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PFAM",
"PANTHER"
] | [
"MF_00511",
"PF00833",
"PTHR10732"
] | [
"Ribosomal_eS17",
"Ribosomal_S17e",
""
] | [
5932,
7151,
6808
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00590",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-72649",
"R-CEL-72689",
"R-CEL-72695",
"R-CEL-72702",
"R-CEL-72706",
"R-CEL-975956",
"R-CEL-975957",
"R-CFA-156827",
"R-CFA-1799339",
"R-CFA-72649",
"R-CFA-72689",
"R-CFA-72695",
"R-CFA-72702",
"R-CFA-72706",
"R-CFA-975956",
"R-... | [
"PROSITEDOC:PDOC00590",
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-1799339",
"REACTOME:R-CEL-72649",
"REACTOME:R-CEL-72689",
"REACTOME:R-CEL-72695",
"REACTOME:R-CEL-72702",
"REACTOME:R-CEL-72706",
"REACTOME:R-CEL-975956",
"REACTOME:R-CEL-975957",
"REACTOME:R-CFA-156827",
"REACTOME:R-CFA-1799339"... | 109 | [
"1rq6",
"3j6x",
"3j6y",
"3j77",
"3j78",
"3j7a",
"3j7p",
"3j7r",
"3j80",
"3j81",
"3jag",
"3jah",
"3jai",
"3jaj",
"3jam",
"3jan",
"3jap",
"3jbn",
"3jbo",
"3jbp",
"4bts",
"4d5l",
"4d61",
"4kzx",
"4kzy",
"4kzz",
"4u3m",
"4u3n",
"4u3u",
"4u4n",
"4u4o",
"4u4q"... | 577 | [
"PUB00001768",
"PUB00001776",
"PUB00003645",
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00059102",
"PUB00080279"
] | [
"3240863",
"2507396",
"6092944",
"11297922",
"11290319",
"11114498",
"22096102",
"24524803"
] | [
"The transcriptionally active human ribosomal protein S17 gene.",
"The Drosophila melanogaster RPS17 gene encoding ribosomal protein S17.",
"Two genes for ribosomal protein 51 of Saccharomyces cerevisiae complement and contribute to the ribosomes.",
"Atomic structures at last: the ribosome in 2000.",
"The r... | [
1988,
1989,
1984,
2001,
2001,
2000,
2011,
2014
] | 8 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Hepatitis E virus",
"ecological metagenomes"
] | [
891,
5,
6207,
10,
40
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
2,
1,
7,
4,
1,
5,
12,
2,
2,
8
] | 12 | true | Family | Small ribosomal subunit protein eS17 | Small ribosomal subunit protein eS17 | Ribosomal_eS17 | 8 |
IPR001212 | 1,212 | Somatomedin B domain | Somatomedin_B_dom | Domain | 15,414 | false | false | Somatomedin B (SMB), a serum factor of unknown function, is a small cysteine-rich peptide, derived proteolytically from the N terminus of the cell-substrate adhesion protein vitronectin [ ]. Cys-rich somatomedin B-like domains are found in a number of proteins [ ], including ectonucleotide pyrophosphatase/phosphodieste... | [] | [] | [] | 0 | [
"PFAM",
"PROSITE",
"PROFILE",
"SMART"
] | [
"PF01033",
"PS00524",
"PS50958",
"SM00201"
] | [
"Somatomedin_B",
"SMB_1",
"SMB_2",
"SO"
] | [
10770,
13211,
15279,
9615
] | 4 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00453",
"R-BTA-5173214",
"R-HSA-196843",
"R-HSA-199220",
"R-HSA-2129379",
"R-HSA-216083",
"R-HSA-3000170",
"R-HSA-3000178",
"R-HSA-5083635",
"R-HSA-5173214",
"R-HSA-977606",
"R-HSA-9925563",
"R-MMU-196843",
"R-MMU-2129379",
"R-MMU-216083",
"R-MMU-3000170",
"R-MMU-3000178",
"R-... | [
"PROSITEDOC:PDOC00453",
"REACTOME:R-BTA-5173214",
"REACTOME:R-HSA-196843",
"REACTOME:R-HSA-199220",
"REACTOME:R-HSA-2129379",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-3000170",
"REACTOME:R-HSA-3000178",
"REACTOME:R-HSA-5083635",
"REACTOME:R-HSA-5173214",
"REACTOME:R-HSA-977606",
"REACTOME:R-HS... | 25 | [
"1oc0",
"1s4g",
"1ssu",
"2cqw",
"2jq8",
"2xr9",
"2xrg",
"2ys0",
"3bt1",
"3bt2",
"3nkm",
"3nkn",
"3nko",
"3nkp",
"3nkq",
"3nkr",
"3wav",
"3waw",
"3wax",
"3way",
"4b56",
"4gtw",
"4gtx",
"4gty",
"4gtz",
"4k24",
"4zg6",
"4zg7",
"4zg9",
"4zga",
"5dlt",
"5dlv"... | 289 | [
"PUB00000196",
"PUB00000290",
"PUB00004746",
"PUB00015354",
"PUB00015355",
"PUB00015356"
] | [
"1710108",
"2447940",
"1647027",
"12533192",
"15157085",
"12808446"
] | [
"Homology of placental protein 11 and pea seed albumin 2 with vitronectin.",
"Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the \"pexin\" family and a model for their evolution.",
"Identification of nucleotide pyrophosphatase/alkaline phosphodiesterase I activity ... | [
1991,
1987,
1991,
2003,
2004,
2003
] | 6 | [] | [
"IPR020436"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanosarcina barkeri",
"metagenomes"
] | [
38,
15371,
3,
2
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
46,
82,
36,
28,
45
] | 6 | true | Domain | Somatomedin B domain | Somatomedin B domain | Somatomedin_B_dom | 8 |
IPR001213 | 1,213 | Mouse mammary tumour virus superantigen | MMTV_SAg | Family | 80 | false | false | The Mouse mammary tumor virus (MMTV) is a milk-transmitted type B retrovirus. The superantigen (SAg) is encoded in the long terminal repeat [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01054"
] | [
"MMTV_SAg"
] | [
80
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000111"
] | [
"7612231"
] | [
"Superantigens of mouse mammary tumor virus."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Muroidea",
"Viruses"
] | [
23,
57
] | 2 | [
"Mus musculus"
] | [
19
] | 1 | true | Family | Mouse mammary tumour virus superantigen | Mouse mammary tumour virus superantigen | MMTV_SAg | 3 |
IPR001214 | 1,214 | SET domain | SET_dom | Domain | 166,826 | false | false | The SET domain is a 130 to 140 amino acid, evolutionary well conserved sequence motif that was initially characterised in the Drosophila proteins Su(var)3-9, Enhancer-of-zeste and Trithorax. In addition to these chromosomal proteins modulating gene activities and/or chromatin structure, the SET domain is found in prote... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00856",
"PF21549",
"PS50280",
"SM00317"
] | [
"SET",
"PRDM2_PR",
"SET",
"SET"
] | [
137944,
21304,
157419,
111048
] | 4 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.1.1",
"PDOC50280",
"R-BTA-2299718",
"R-BTA-3214841",
"R-BTA-6804760",
"R-BTA-9764725",
"R-CEL-2299718",
"R-CEL-2559580",
"R-CEL-3214841",
"R-CEL-8936459",
"R-CEL-8943724",
"R-CEL-9764725",
"R-CEL-9772755",
"R-DDI-3214841",
"R-DDI-9772755",
"R-DME-201722",
"R-DME-212300",
"R-DME-... | [
"EC:2.1.1",
"PROSITEDOC:PDOC50280",
"REACTOME:R-BTA-2299718",
"REACTOME:R-BTA-3214841",
"REACTOME:R-BTA-6804760",
"REACTOME:R-BTA-9764725",
"REACTOME:R-CEL-2299718",
"REACTOME:R-CEL-2559580",
"REACTOME:R-CEL-3214841",
"REACTOME:R-CEL-8936459",
"REACTOME:R-CEL-8943724",
"REACTOME:R-CEL-9764725"... | 117 | [
"1h3i",
"1ml9",
"1mlv",
"1mt6",
"1muf",
"1mvh",
"1mvx",
"1n3j",
"1n6a",
"1n6c",
"1o9s",
"1ozv",
"1p0y",
"1peg",
"1xqh",
"1zkk",
"2bqz",
"2f69",
"2g46",
"2h21",
"2h23",
"2h2e",
"2h2j",
"2igq",
"2jv0",
"2n1i",
"2o8j",
"2qpw",
"2r3a",
"2rfi",
"2w5y",
"2w5z"... | 403 | [
"PUB00005822",
"PUB00007133",
"PUB00014448",
"PUB00018233",
"PUB00018235",
"PUB00018236",
"PUB00018237",
"PUB00048100",
"PUB00054125",
"PUB00054732",
"PUB00095964",
"PUB00152720",
"PUB00152721"
] | [
"9632640",
"12372294",
"10949293",
"9487389",
"12372305",
"12372304",
"12372303",
"18082620",
"12826405",
"20084102",
"24095733",
"24900801",
"19891491"
] | [
"The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression.",
"Structures of SET domain proteins: protein lysine methyltransferases make their mark.",
"Regulation of chromatin structure by site-speci... | [
1998,
2002,
2000,
1998,
2002,
2002,
2002,
2008,
2003,
2010,
2013,
2014,
2009
] | 13 | [] | [
"IPR037841",
"IPR037890",
"IPR044418",
"IPR044419",
"IPR044420",
"IPR044421",
"IPR044422",
"IPR044424",
"IPR044425",
"IPR044426",
"IPR044427",
"IPR044428",
"IPR044429",
"IPR044430",
"IPR044431",
"IPR044432",
"IPR044433",
"IPR044434",
"IPR044435",
"IPR044436",
"IPR044437",
"... | 0 | 26 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
62,
6587,
159809,
139,
229
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
243,
36,
469,
66,
197,
163,
24,
128,
206,
12,
13,
430
] | 12 | true | Domain | SET domain | SET domain | SET_dom | 3 |
IPR001217 | 1,217 | Transcription factor STAT | STAT | Family | 13,105 | false | false | The STAT protein (Signal Transducers and Activators of Transcription) family contains transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors, hence they act as signal transducers in the cytoplasm and transcription activators in the nucleus ... | [
"GO:0003700",
"GO:0006355",
"GO:0007165"
] | [
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription",
"signal transduction"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PANTHER"
] | [
"PTHR11801"
] | [
""
] | [
13105
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1251985",
"R-BTA-1266695",
"R-BTA-1433557",
"R-BTA-186763",
"R-BTA-512988",
"R-BTA-8854691",
"R-BTA-8983432",
"R-BTA-8985947",
"R-BTA-9020558",
"R-BTA-9020958",
"R-CEL-1059683",
"R-CEL-1169408",
"R-CEL-1251985",
"R-CEL-186763",
"R-CEL-201556",
"R-CEL-3249367",
"R-CEL-6783783",... | [
"REACTOME:R-BTA-1251985",
"REACTOME:R-BTA-1266695",
"REACTOME:R-BTA-1433557",
"REACTOME:R-BTA-186763",
"REACTOME:R-BTA-512988",
"REACTOME:R-BTA-8854691",
"REACTOME:R-BTA-8983432",
"REACTOME:R-BTA-8985947",
"REACTOME:R-BTA-9020558",
"REACTOME:R-BTA-9020958",
"REACTOME:R-CEL-1059683",
"REACTOME:... | 234 | [
"1bf5",
"1bg1",
"1bgf",
"1uur",
"1uus",
"1y1u",
"1yvl",
"3cwg",
"3wwt",
"4e68",
"4y5u",
"4y5w",
"4zia",
"5d39",
"5oen",
"6mbw",
"6mbz",
"6njs",
"6nuq",
"6qhd",
"6tlc",
"6ux2",
"6wcz",
"7nuf",
"7tva",
"7tvb",
"7ubt",
"7uc6",
"7uc7",
"7zn7",
"7znn",
"8d3f"... | 37 | [
"PUB00007134",
"PUB00011807",
"PUB00032712",
"PUB00051157"
] | [
"12039028",
"9630226",
"15780933",
"18433722"
] | [
"Signaling through the JAK/STAT pathway, recent advances and future challenges.",
"Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.",
"Structural bases of unphosphorylated STAT1 association and receptor binding.",
"Crystal structure of unphosphorylated STAT3 core fragment."
] | [
2002,
1998,
2005,
2008
] | 4 | [] | [] | 0 | 0 | null | [
"Clandestinovirus",
"Eukaryota",
"Rhodobacter flavimaris",
"bird metagenome"
] | [
1,
13101,
1,
2
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
9,
30,
7,
127,
43,
5,
33,
13
] | 9 | true | Family | Transcription factor STAT | Transcription factor STAT | STAT | 3 |
IPR001218 | 1,218 | Nucleocapsid protein, coronavirus | Nucleocap_CoV | Family | 4,270 | false | false | The Nucleocapsid (N) protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signalling pathways. The N protein interacts with genomic and subgenomic RNA molecules. Together with the envelope protein M, it participates in genome condensation and packaging. The N... | [
"GO:0003723",
"GO:0019013"
] | [
"RNA binding",
"viral nucleocapsid"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PIRSF"
] | [
"PF00937",
"PIRSF003888"
] | [
"CoV_nucleocap",
"Corona_nucleocap"
] | [
4270,
3435
] | 2 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp1009",
"R-HSA-1257604",
"R-HSA-168638",
"R-HSA-168928",
"R-HSA-389357",
"R-HSA-445989",
"R-HSA-5218920",
"R-HSA-9020702",
"R-HSA-909733",
"R-HSA-9678110",
"R-HSA-9679509",
"R-HSA-9682708",
"R-HSA-9683610",
"R-HSA-9683701",
"R-HSA-9692914",
"R-HSA-9692916",
"R-HSA-9694322",
... | [
"GP:GenProp1009",
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA-168638",
"REACTOME:R-HSA-168928",
"REACTOME:R-HSA-389357",
"REACTOME:R-HSA-445989",
"REACTOME:R-HSA-5218920",
"REACTOME:R-HSA-9020702",
"REACTOME:R-HSA-909733",
"REACTOME:R-HSA-9678110",
"REACTOME:R-HSA-9679509",
"REACTOME:R-HSA-96827... | 26 | [
"1ssk",
"2btl",
"2bxx",
"2c86",
"2ca1",
"2cjr",
"2ge7",
"2ge8",
"2gec",
"2gib",
"2jw8",
"2ofz",
"2og3",
"3hd4",
"4j3k",
"4kxj",
"4li4",
"4lm7",
"4lm9",
"4lmc",
"4lmt",
"4ud1",
"5epw",
"5n4k",
"6g13",
"6kl2",
"6kl5",
"6kl6",
"6lnn",
"6lz6",
"6lz8",
"6m3m"... | 108 | [
"PUB00094055",
"PUB00094059",
"PUB00094060",
"PUB00094095",
"PUB00094096",
"PUB00094097",
"PUB00094098",
"PUB00099891"
] | [
"31776274",
"28720894",
"25299332",
"16494977",
"32106567",
"12862314",
"16112641",
"33039147"
] | [
"Nucleocapsid Protein Recruitment to Replication-Transcription Complexes Plays a Crucial Role in Coronaviral Life Cycle.",
"Coronavirus nucleocapsid proteins assemble constitutively in high molecular oligomers.",
"Nucleocapsid phosphorylation and RNA helicase DDX1 recruitment enables coronavirus transition from... | [
2020,
2017,
2014,
2006,
2020,
2003,
2005,
2021
] | 8 | [] | [
"IPR042547",
"IPR042548",
"IPR043505"
] | 0 | 3 | 0 | [
"Nidovirales",
"Pseudomonas oryzicola"
] | [
4269,
1
] | 2 | [] | [] | 0 | true | Family | Nucleocapsid protein, coronavirus | Nucleocapsid protein, coronavirus | Nucleocap_CoV | 9 |
IPR001220 | 1,220 | Legume lectin domain | Legume_lectin_dom | Domain | 24,146 | false | false | Lectins are carbohydrate-binding proteins. Leguminous lectins form one of the largest lectin families and resemble each other in their physicochemical properties, though they differ in their carbohydrate specificities. They bind either glucose/mannose or galactose [ ]. Carbohydrate-binding activity depends on the simul... | [
"GO:0030246"
] | [
"carbohydrate binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"CDD"
] | [
"PF00139",
"cd06899"
] | [
"Lectin_legB",
"lectin_legume_LecRK_Arcelin_ConA"
] | [
24146,
20211
] | 2 | [
"PROSITEDOC"
] | [
"PDOC00278"
] | [
"PROSITEDOC:PDOC00278"
] | 1 | [
"1apn",
"1avb",
"1ax0",
"1ax1",
"1ax2",
"1axy",
"1axz",
"1azd",
"1bjq",
"1bqp",
"1bxh",
"1bzw",
"1c57",
"1ces",
"1ciw",
"1cjp",
"1cn1",
"1con",
"1cq9",
"1cr7",
"1cvn",
"1dbn",
"1dgl",
"1dhk",
"1dq0",
"1dq1",
"1dq2",
"1dq4",
"1dq5",
"1dq6",
"1dzq",
"1enq"... | 346 | [
"PUB00001507",
"PUB00046607",
"PUB00057387",
"PUB00057388",
"PUB00057389",
"PUB00057390"
] | [
"2227211",
"9546043",
"16441240",
"36624",
"3965973",
"8373823"
] | [
"Legume lectins--a large family of homologous proteins.",
"Legume lectin structure.",
"Dual-function protein in plant defence: seed lectin from Dolichos biflorus (horse gram) exhibits lipoxygenase activity.",
"The Rhizobium--legume symbiosis.",
"Polypeptide ligation occurs during post-translational modifica... | [
1990,
1998,
2006,
1979,
1985,
1993
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanolobus zinderi",
"ecological metagenomes"
] | [
303,
23838,
1,
4
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
256,
272,
137
] | 3 | true | Domain | Legume lectin domain | Legume lectin domain | Legume_lectin_dom | 8 |
IPR001222 | 1,222 | Zinc finger, TFIIS-type | Znf_TFIIS | Domain | 20,810 | false | false | Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b... | [
"GO:0003676",
"GO:0008270",
"GO:0006351"
] | [
"nucleic acid binding",
"zinc ion binding",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM",
"PROSITE",
"PROFILE",
"SMART"
] | [
"PF01096",
"PS00466",
"PS51133",
"SM00440"
] | [
"Zn_ribbon_TFIIS",
"ZF_TFIIS_1",
"ZF_TFIIS_2",
"ZnF_C2C2"
] | [
20656,
12676,
20500,
20287
] | 4 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00383",
"R-BTA-5250924",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-73762",
"R-BTA-73772",
"R-BTA-73863",
"R-BTA-75955",
"R-CEL-112382",
"R-CEL-113418",
"R-CEL-5578749",
"R-CEL-674695",
"R-CEL-6781823",
"R-CEL-6782135",
"R-CEL-67... | [
"PROSITEDOC:PDOC00383",
"REACTOME:R-BTA-5250924",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-73762",
"REACTOME:R-BTA-73772",
"REACTOME:R-BTA-73863",
"REACTOME:R-BTA-75955",
"REACTOME:R-CEL-112... | 207 | [
"1i3q",
"1i50",
"1i6h",
"1k83",
"1nik",
"1nt9",
"1pqv",
"1qyp",
"1r5u",
"1r9s",
"1r9t",
"1sfo",
"1tfi",
"1twa",
"1twc",
"1twf",
"1twg",
"1twh",
"1wcm",
"1y1v",
"1y1w",
"1y1y",
"1y77",
"2b63",
"2b8k",
"2e2h",
"2e2i",
"2e2j",
"2ja5",
"2ja6",
"2ja7",
"2ja8"... | 527 | [
"PUB00002480",
"PUB00003664",
"PUB00004154",
"PUB00011910",
"PUB00014077",
"PUB00017221",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812"
] | [
"3346229",
"2398897",
"7626141",
"12914699",
"12665246",
"10723030",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890"
] | [
"Molecular cloning and characterization of cDNA for eukaryotic transcription factor S-II.",
"Identification of rpo30, a vaccinia virus RNA polymerase gene with structural similarity to a eucaryotic transcription elongation factor.",
"Structure of a new nucleic-acid-binding motif in eukaryotic transcriptional el... | [
1988,
1990,
1993,
2003,
2002,
2000,
2007,
2005,
2005,
1999,
2001
] | 11 | [] | [
"IPR034004",
"IPR034012",
"IPR034014"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
1278,
21,
18727,
469,
315
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
23,
5,
57,
9,
14,
18,
4,
23,
21,
4,
4,
31
] | 12 | true | Domain | Zinc finger, TFIIS-type | Zinc finger, TFIIS-type | Znf_TFIIS | 6 |
IPR001223 | 1,223 | Glycoside hydrolase family 18, catalytic domain | Glyco_hydro18_cat | Domain | 89,465 | false | false | The glycosyl hydrolases family 18 (GH18) is widely distributed in all kingdoms and contains hydrolytic enzymes with chitinase or endo-N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase-like lectins (chi-lectins/proteins (CLPs). Chitinases ( ) are hydrolytic enzymes that cleave the beta-1,4-bond rele... | [
"GO:0005975"
] | [
"carbohydrate metabolic process"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PROFILE"
] | [
"PF00704",
"PS51910"
] | [
"Glyco_hydro_18",
"GH18_2"
] | [
83709,
87881
] | 2 | [
"CAZY",
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"... | [
"GH18",
"3.2.1",
"GenProp1522",
"R-BTA-114608",
"R-CEL-189085",
"R-CEL-6798695",
"R-DDI-114608",
"R-DME-189085",
"R-DME-6798695",
"R-DRE-114608",
"R-HSA-114608",
"R-HSA-189085",
"R-HSA-2534343",
"R-HSA-6798695",
"R-MMU-114608",
"R-MMU-189085",
"R-MMU-2534343",
"R-MMU-6798695",
"R... | [
"CAZY:GH18",
"EC:3.2.1",
"GP:GenProp1522",
"REACTOME:R-BTA-114608",
"REACTOME:R-CEL-189085",
"REACTOME:R-CEL-6798695",
"REACTOME:R-DDI-114608",
"REACTOME:R-DME-189085",
"REACTOME:R-DME-6798695",
"REACTOME:R-DRE-114608",
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-189085",
"REACTOME:R-HSA-253434... | 26 | [
"1c3f",
"1c8x",
"1c8y",
"1c90",
"1c91",
"1c92",
"1c93",
"1cnv",
"1ctn",
"1d2k",
"1e15",
"1e6n",
"1e6p",
"1e6r",
"1e6z",
"1e9l",
"1edq",
"1edt",
"1ehn",
"1eib",
"1eok",
"1eom",
"1ffq",
"1ffr",
"1goi",
"1gpf",
"1guv",
"1h0g",
"1h0i",
"1hjv",
"1hjw",
"1hjx"... | 413 | [
"PUB00004870",
"PUB00005266",
"PUB00061053",
"PUB00084156",
"PUB00093760",
"PUB00093762"
] | [
"7624375",
"8535779",
"22742450",
"22550243",
"22859955",
"24380021"
] | [
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases.",
"Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.",
"Chitinase-like proteins in lung injury, repair, a... | [
1995,
1995,
2012,
2012,
2012,
2013
] | 6 | [] | [
"IPR011583",
"IPR045321"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
174,
31661,
56740,
307,
583
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
56,
39,
46,
45,
2,
48,
33,
13,
90,
39,
2,
1,
73
] | 13 | true | Domain | Glycoside hydrolase family 18, catalytic domain | Glycoside hydrolase family 18, catalytic domain | Glyco_hydro18_cat | 1 |
IPR001224 | 1,224 | Vasopressin V1A receptor | Vprs_V1A_rcpt | Family | 1,252 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0005000",
"GO:0007186",
"GO:0016020"
] | [
"vasopressin receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00752"
] | [
"VASOPRSNV1AR"
] | [
1252
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"366",
"R-HSA-388479",
"R-HSA-416476",
"R-HSA-5619099",
"R-MMU-388479",
"R-MMU-416476",
"R-RNO-388479",
"R-RNO-416476"
] | [
"IUPHAR:366",
"REACTOME:R-HSA-388479",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-5619099",
"REACTOME:R-MMU-388479",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-388479",
"REACTOME:R-RNO-416476"
] | 8 | [] | 0 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"The G protein-coupled receptor repertoires of human and mouse.",
"GCRDb: a G-protein-coup... | [
1990,
1988,
1993,
1994,
2003,
1994,
2005,
2009,
2006,
2013
] | 10 | [
"IPR001817"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
1252
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
3,
3
] | 4 | true | Family | Vasopressin V1A receptor | Vasopressin V1A receptor | Vprs_V1A_rcpt | 1 |
IPR001226 | 1,226 | Flavodoxin, conserved site | Flavodoxin_CS | Conserved_site | 21,309 | false | false | Flavodoxins are electron-transfer proteins that function in various electron transport systems. Flavodoxins bind one FMN molecule, which serves as a redox-active prosthetic group [ ] and are functionally interchangeable with ferredoxins. They have been isolated from prokaryotes, cyanobacteria, and some eukaryotic algae... | [
"GO:0009055",
"GO:0010181"
] | [
"electron transfer activity",
"FMN binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PROSITE"
] | [
"PS00201"
] | [
"FLAVODOXIN"
] | [
21309
] | 1 | [
"PROSITEDOC"
] | [
"PDOC00178"
] | [
"PROSITEDOC:PDOC00178"
] | 1 | [
"1ag9",
"1ahn",
"1akq",
"1akr",
"1akt",
"1aku",
"1akv",
"1akw",
"1azl",
"1bu5",
"1c7e",
"1c7f",
"1czh",
"1czk",
"1czl",
"1czn",
"1czo",
"1czr",
"1czu",
"1d03",
"1d04",
"1dx9",
"1f4p",
"1fla",
"1fld",
"1fln",
"1flv",
"1ftg",
"1fvx",
"1fx1",
"1i1o",
"1j8q"... | 122 | [
"PUB00000480",
"PUB00043026",
"PUB00094592"
] | [
"2597140",
"16672604",
"19583219"
] | [
"The amino acid sequence of a flavodoxin from the eukaryotic red alga Chondrus crispus.",
"WrbA from Escherichia coli and Archaeoglobus fulgidus is an NAD(P)H:quinone oxidoreductase.",
"Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity."
... | [
1989,
2006,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
438,
20055,
542,
23,
251
] | 5 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Conserved_site | Flavodoxin, conserved site | Flavodoxin, conserved site | Flavodoxin_CS | 6 |
IPR001227 | 1,227 | Acyl transferase domain superfamily | Ac_transferase_dom_sf | Homologous_superfamily | 112,726 | false | false | Enzymes like bacterial malonyl CoA-acly carrier protein transacylase ( ) and eukaryotic fatty acid synthase ( ) that are involved in fatty acid biosynthesis belong to this group [ ]. Also included are the polyketide synthases 6-methylsalicylic acid synthase ( ), a multifunctional enzyme that involved in the biosynthesi... | [
"GO:0016740"
] | [
"transferase activity"
] | [
"molecular_function"
] | 1 | [
"CATHGENE3D"
] | [
"G3DSA:3.40.366.10"
] | [
""
] | [
112726
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"2.3.1",
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
... | [
"EC:2.3.1",
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"... | 237 | [
"1mla",
"1nm2",
"2c2n",
"2cdh",
"2cf2",
"2cuy",
"2g1h",
"2g2o",
"2g2y",
"2g2z",
"2h1y",
"2hg4",
"2jfd",
"2jfk",
"2pff",
"2qc3",
"2qj3",
"2qo3",
"2uv8",
"2vkz",
"2vz8",
"2vz9",
"3ezo",
"3g87",
"3h0p",
"3hhd",
"3hjv",
"3hmj",
"3im8",
"3im9",
"3k89",
"3ptw"... | 220 | [
"PUB00099666"
] | [
"19549604"
] | [
"Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
27,
74076,
37837,
786
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
6,
4,
10,
7,
2,
4,
7,
9,
3,
4,
2,
2,
7
] | 13 | true | Homologous_superfamily | Acyl transferase domain superfamily | Acyl transferase domain superfamily | Ac_transferase_dom_sf | 8 |
IPR001228 | 1,228 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | IspD | Family | 21,781 | false | false | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) catalyses the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) in the deoxyxylulose pathway of isopentenyl diphosphate (IPP) biosynthesis [ ]. This mevalonate independent pathway that utilizes p... | [
"GO:0050518",
"GO:0008299"
] | [
"2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity",
"isoprenoid biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00108",
"TIGR00453"
] | [
"IspD",
"ispD"
] | [
20774,
20060
] | 2 | [
"EC",
"GP",
"GP",
"METACYC",
"PROSITEDOC"
] | [
"2.7.7.60",
"GenProp0048",
"GenProp1295",
"PWY-7560",
"PDOC00997"
] | [
"EC:2.7.7.60",
"GP:GenProp0048",
"GP:GenProp1295",
"METACYC:PWY-7560",
"PROSITEDOC:PDOC00997"
] | 5 | [
"1h3m",
"1i52",
"1ini",
"1inj",
"1vgt",
"1vgu",
"1vgw",
"1vgz",
"1vpa",
"1w55",
"1w57",
"1w77",
"2px7",
"2xwl",
"2xwm",
"2xwn",
"2yc3",
"2yc5",
"2ycm",
"3n9w",
"3okr",
"3q7u",
"3q80",
"4kt7",
"4myb",
"4nai",
"4nak",
"4nal",
"4nan",
"4ys8",
"4zdq",
"5ddt"... | 46 | [
"PUB00011033",
"PUB00043297",
"PUB00043298"
] | [
"10841550",
"17081012",
"17921290"
] | [
"Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana.",
"Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods.",
"Characterization of the Mycobacterium tuberculosis 4-diphosphocytidy... | [
2000,
2006,
2007
] | 3 | [
"IPR034683"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
8,
20641,
765,
367
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
1,
1,
11
] | 4 | true | Family | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | IspD | 3 |
IPR001232 | 1,232 | S-phase kinase-associated protein 1-like | SKP1-like | Family | 18,297 | false | false | This entry includes SKP1 and SKP1-like protein, elongin-C (also known as TCEB1). SKP1 is part of the E3 ubiquitin ligase complexes. Elongin-C has dual functions, works as a component of RNA polymerase II (Pol II) transcription elongation factor and as the substrate recognition subunit of a Cullin-RING E3 ubiquitin liga... | [
"GO:0006511"
] | [
"ubiquitin-dependent protein catabolic process"
] | [
"biological_process"
] | 1 | [
"SMART"
] | [
"SM00512"
] | [
"Skp1"
] | [
18297
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1169091",
"R-BTA-1234176",
"R-BTA-174113",
"R-BTA-187577",
"R-BTA-195253",
"R-BTA-202424",
"R-BTA-2565942",
"R-BTA-2871837",
"R-BTA-5607761",
"R-BTA-5607764",
"R-BTA-5610780",
"R-BTA-5610785",
"R-BTA-5676590",
"R-BTA-5684264",
"R-BTA-674695",
"R-BTA-6796648",
"R-BTA-68949",
... | [
"REACTOME:R-BTA-1169091",
"REACTOME:R-BTA-1234176",
"REACTOME:R-BTA-174113",
"REACTOME:R-BTA-187577",
"REACTOME:R-BTA-195253",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-2565942",
"REACTOME:R-BTA-2871837",
"REACTOME:R-BTA-5607761",
"REACTOME:R-BTA-5607764",
"REACTOME:R-BTA-5610780",
"REACTOME:R-... | 192 | [
"1fqv",
"1fs1",
"1fs2",
"1hv2",
"1ldk",
"1lm8",
"1lqb",
"1nex",
"1p22",
"1vcb",
"2ass",
"2ast",
"2c9w",
"2e31",
"2e32",
"2fnj",
"2izv",
"2jz3",
"2ma9",
"2ovp",
"2ovq",
"2ovr",
"2p1m",
"2p1n",
"2p1o",
"2p1p",
"2p1q",
"3c6n",
"3c6o",
"3c6p",
"3dcg",
"3l2o"... | 328 | [
"PUB00006069",
"PUB00058708",
"PUB00067735",
"PUB00068343",
"PUB00072441",
"PUB00076424",
"PUB00076434"
] | [
"8670864",
"20181953",
"11283612",
"15590694",
"17296727",
"25460509",
"25878247"
] | [
"The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution.",
"Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase.",
"Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assemb... | [
1996,
2010,
2001,
2005,
2007,
2015,
2015
] | 7 | [] | [
"IPR016897",
"IPR039948"
] | 0 | 2 | 0 | [
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
18266,
23,
8
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
68,
26,
4,
18,
11,
7,
3,
59,
14,
2,
2,
102
] | 12 | true | Family | S-phase kinase-associated protein 1-like | S-phase kinase-associated protein 1-like | SKP1-like | 3 |
IPR001233 | 1,233 | RNA-splicing ligase, RtcB | RtcB | Family | 19,194 | false | false | RctB is a RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. It probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester [ ... | [
"GO:0008452",
"GO:0006396"
] | [
"RNA ligase activity",
"RNA processing"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROSITE",
"PANTHER"
] | [
"PF01139",
"PS01288",
"PTHR11118"
] | [
"RtcB",
"UPF0027",
""
] | [
19178,
4306,
8731
] | 3 | [
"EC",
"GP",
"METACYC",
"PROSITEDOC",
"REACTOME"
] | [
"6.5.1.8",
"GenProp1707",
"PWY-7803",
"PDOC00990",
"R-HSA-6784531"
] | [
"EC:6.5.1.8",
"GP:GenProp1707",
"METACYC:PWY-7803",
"PROSITEDOC:PDOC00990",
"REACTOME:R-HSA-6784531"
] | 5 | [
"1uc2",
"2epg",
"4dwq",
"4dwr",
"4isj",
"4isz",
"4it0",
"7lfq",
"7p3b",
"8btt",
"8dc9",
"8dca",
"8dcb",
"8dcd",
"8dcf",
"8dcg",
"8odo",
"8odp",
"8orj",
"9i8v"
] | 20 | [
"PUB00057853",
"PUB00065771",
"PUB00101165",
"PUB00101166",
"PUB00101167"
] | [
"21224389",
"22949672",
"22320833",
"25429148",
"25366321"
] | [
"RtcB is the RNA ligase component of an Escherichia coli RNA repair operon.",
"Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH.",
"tRNA ligase catalyzes the GTP-dependent ligation of RNA with 3'-phosphate and 5'-hydroxyl term... | [
2011,
2012,
2012,
2014,
2014
] | 5 | [] | [
"IPR017510",
"IPR027513"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1019,
14005,
3545,
272,
353
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
1,
4,
2,
5
] | 7 | true | Family | RNA-splicing ligase, RtcB | RNA-splicing ligase, RtcB | RtcB | 6 |
IPR001234 | 1,234 | GPCR, family 3, metabotropic glutamate receptor 3 | GPCR_3_mGluR3 | Family | 1,472 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01053"
] | [
"MTABOTROPC3R"
] | [
1472
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"291",
"R-HSA-418594",
"R-HSA-420499",
"R-MMU-418594",
"R-MMU-420499",
"R-RNO-418594",
"R-RNO-420499"
] | [
"IUPHAR:291",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-420499",
"REACTOME:R-MMU-418594",
"REACTOME:R-MMU-420499",
"REACTOME:R-RNO-418594",
"REACTOME:R-RNO-420499"
] | 7 | [
"2e4u",
"2e4v",
"2e4w",
"2e4x",
"2e4y",
"3sm9",
"4xar",
"5cnk",
"5cnm",
"6b7h",
"7wi6",
"7wi8",
"7wih",
"8jcu",
"8jcv",
"8jcw",
"8jcx",
"8jcy",
"8jcz",
"8jd0",
"8jd1",
"8jd2",
"8jd3",
"8tqb",
"8tr0",
"8tr2",
"8trc",
"8trd",
"9ii2",
"9ii3"
] | 30 | [
"PUB00000775",
"PUB00002720",
"PUB00004090",
"PUB00004161",
"PUB00004309",
"PUB00004961",
"PUB00005138",
"PUB00007343",
"PUB00036049",
"PUB00036050",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00100448",
"PUB00100449",
"PUB001004... | [
"8840013",
"1320017",
"1847995",
"8255296",
"1309649",
"8170923",
"1656524",
"9292726",
"17266540",
"10773016",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"28114282",
"31925813",
"30488581"
] | [
"Molecular characterization and localization of human metabotropic glutamate receptor type 3.",
"Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.",
"Sequence and expression of a metabotropic glutamate receptor.",
"Cloning and ... | [
1996,
1992,
1991,
1993,
1992,
1994,
1991,
1997,
2007,
2000,
2003,
1994,
2005,
2009,
2006,
2013,
2017,
2020,
2018
] | 19 | [
"IPR000162"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
1472
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
7,
2,
4
] | 4 | true | Family | GPCR, family 3, metabotropic glutamate receptor 3 | GPCR, family 3, metabotropic glutamate receptor 3 | GPCR_3_mGluR3 | 4 |
IPR001235 | 1,235 | Blue (type 1) copper protein, plastocyanin-type | Copper_blue_Plastocyanin | Family | 2,967 | false | false | null | [
"GO:0005507",
"GO:0009055"
] | [
"copper ion binding",
"electron transfer activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PRINTS"
] | [
"PR00156"
] | [
"COPPERBLUE"
] | [
2967
] | 1 | [] | [] | [] | 0 | [
"1aac",
"1aaj",
"1aan",
"1adw",
"1ag6",
"1b3i",
"1baw",
"1bqk",
"1bqr",
"1bxa",
"1bxu",
"1bxv",
"1byo",
"1byp",
"1fa4",
"1id2",
"1iuz",
"1j5c",
"1j5d",
"1jxd",
"1jxf",
"1jxg",
"1kdi",
"1kdj",
"1m9w",
"1mda",
"1mg2",
"1mg3",
"1nin",
"1oow",
"1paz",
"1pcs"... | 149 | [
"PUB00003327",
"PUB00003425"
] | [
"8035459",
"8433378"
] | [
"Solution structure of the type 1 blue copper protein amicyanin from Thiobacillus versutus.",
"Evolution of protein complexity: the blue copper-containing oxidases and related proteins."
] | [
1994,
1993
] | 2 | [] | [
"IPR002386",
"IPR002387"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"ecological metagenomes"
] | [
29,
2067,
59,
802,
10
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
1,
6
] | 3 | true | Family | Blue (type 1) copper protein, plastocyanin-type | Blue (type 1) copper protein, plastocyanin-type | Copper_blue_Plastocyanin | 8 |
IPR001236 | 1,236 | Lactate/malate dehydrogenase, N-terminal | Lactate/malate_DH_N | Domain | 65,566 | false | false | This entry represents the N-terminal, and is thought to be a Rossmann NAD-binding fold. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis [ ]. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes.... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00056"
] | [
"Ldh_1_N"
] | [
65566
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"1.1.1",
"1.1.1.37",
"PWY-1622",
"PWY-5392",
"PWY-561",
"PWY-5690",
"PWY-6728",
"PWY-6969",
"PWY-7115",
"PWY-7383",
"PWY-8086",
"R-BTA-70268",
"R-BTA-71403",
"R-BTA-9837999",
"R-BTA-9856872",
"R-BTA-9861718",
"R-CEL-70268",
"R-CEL-71403",
"R-CEL-9837999",
"R-CEL-9856872",
"R-... | [
"EC:1.1.1",
"EC:1.1.1.37",
"METACYC:PWY-1622",
"METACYC:PWY-5392",
"METACYC:PWY-561",
"METACYC:PWY-5690",
"METACYC:PWY-6728",
"METACYC:PWY-6969",
"METACYC:PWY-7115",
"METACYC:PWY-7383",
"METACYC:PWY-8086",
"REACTOME:R-BTA-70268",
"REACTOME:R-BTA-71403",
"REACTOME:R-BTA-9837999",
"REACTOM... | 53 | [
"1a5z",
"1b8p",
"1b8u",
"1b8v",
"1bdm",
"1bmd",
"1ceq",
"1cet",
"1civ",
"1d3a",
"1emd",
"1ez4",
"1guy",
"1guz",
"1gv0",
"1gv1",
"1hlp",
"1hye",
"1hyg",
"1hyh",
"1i0z",
"1i10",
"1ib6",
"1ie3",
"1iz9",
"1ldb",
"1ldg",
"1ldm",
"1ldn",
"1llc",
"1lld",
"1lth"... | 328 | [
"PUB00025866",
"PUB00027386"
] | [
"11276087",
"8117664"
] | [
"Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.",
"Refined crystal structure of mitochondrial malate dehydrogenase from porcine heart and the consensus structure for dicarboxylic acid oxidoreductases."
] | [
2001,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
856,
32637,
31512,
1,
560
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
51,
4,
26,
13,
1,
50,
37,
3,
32,
42,
3,
2,
67
] | 13 | true | Domain | Lactate/malate dehydrogenase, N-terminal | Lactate/malate dehydrogenase, N-terminal | Lactate/malate_DH_N | 3 |
IPR001238 | 1,238 | DNA-binding, RecF | DNA-binding_RecF | Family | 22,598 | false | false | RecF belongs to the AAA+ superfamily of ATPases. All proteins in this family, including recF, are DNA binding proteins that assist the filamentation of RecA onto DNA for the initiation of recombination or recombinational repair. RecF is involved in DNA metabolism and is required for recombinational DNA repair and for i... | [
"GO:0003697",
"GO:0005524",
"GO:0006281"
] | [
"single-stranded DNA binding",
"ATP binding",
"DNA repair"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00365",
"TIGR00611"
] | [
"RecF",
"recf"
] | [
22598,
22155
] | 2 | [
"GP",
"PROSITEDOC"
] | [
"GenProp0491",
"PDOC00539"
] | [
"GP:GenProp0491",
"PROSITEDOC:PDOC00539"
] | 2 | [
"2o5v",
"5z67",
"5z68",
"5z69",
"5zwu",
"8a8j",
"8a93",
"8bpr"
] | 8 | [
"PUB00003768",
"PUB00004414",
"PUB00057226"
] | [
"7898435",
"1542576",
"11473577"
] | [
"Nucleotide sequence of the recF gene cluster from Staphylococcus aureus and complementation analysis in Bacillus subtilis recF mutants.",
"Sequence and complementation analysis of recF genes from Escherichia coli, Salmonella typhimurium, Pseudomonas putida and Bacillus subtilis: evidence for an essential phospha... | [
1995,
1992,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"Stenosarchaea group",
"unclassified sequences"
] | [
22136,
43,
1,
3,
415
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | DNA-binding, RecF | DNA-binding, RecF | DNA-binding_RecF | 6 |
IPR001239 | 1,239 | Proteinase inhibitor I1, Kazal-type, metazoa | Prot_inh_Kazal-m | Family | 2,246 | false | false | This family of Kazal eukaryotic proteinase inhibitors, belongs to MEROPS inhibitor family I1, clan IA. They inhibit serine peptidases of the S1 family ( ) [ ]. They are restricted to the metazoa (arthropoda and chordata), and includes a single exception in the alveolata (apicomplexa). No members are found in nematodes,... | [
"GO:0004867"
] | [
"serine-type endopeptidase inhibitor activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR00290"
] | [
"KAZALINHBTR"
] | [
2246
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6809371",
"R-HSA-9925561",
"R-MMU-6809371",
"R-RNO-6809371"
] | [
"REACTOME:R-HSA-6809371",
"REACTOME:R-HSA-9925561",
"REACTOME:R-MMU-6809371",
"REACTOME:R-RNO-6809371"
] | 4 | [
"1cgi",
"1cgj",
"1cho",
"1cso",
"1ct0",
"1ct2",
"1ct4",
"1ds2",
"1ds3",
"1hja",
"1hpt",
"1iy5",
"1iy6",
"1m8b",
"1m8c",
"1omt",
"1omu",
"1ovo",
"1pce",
"1ppf",
"1r0r",
"1sgd",
"1sge",
"1sgn",
"1sgp",
"1sgq",
"1sgr",
"1sgy",
"1tgs",
"1tur",
"1tus",
"1y1b"... | 55 | [
"PUB00000276",
"PUB00000286",
"PUB00003203",
"PUB00014133"
] | [
"7046785",
"3828298",
"6699915",
"14705960"
] | [
"Thermodynamics and kinetics of single residue replacements in avian ovomucoid third domains: effect on inhibitor interactions with serine proteinases.",
"Ovomucoid third domains from 100 avian species: isolation, sequences, and hypervariability of enzyme-inhibitor contact residues.",
"Secondary structure in th... | [
1982,
1987,
1984,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2246
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
4,
9,
8
] | 4 | true | Family | Proteinase inhibitor I1, Kazal-type, metazoa | Proteinase inhibitor I1, Kazal-type, metazoa | Prot_inh_Kazal-m | 8 |
IPR001240 | 1,240 | N-(5'phosphoribosyl) anthranilate isomerase (PRAI) domain | PRAI_dom | Domain | 24,329 | false | false | N-(5'-phosphoribosyl) anthranilate isomerase (PRAI) is an enzyme that catalyses the third step of tryptophan biosynthesis. This domain can also be found at the C terminus of several multifunctional enzymes such as tryptophan biosynthesis protein TrpCF, TRP1 and TrpC. Phosphoribosylanthranilate isomerase is monomeric an... | [
"GO:0004640",
"GO:0006568"
] | [
"phosphoribosylanthranilate isomerase activity",
"L-tryptophan metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PFAM",
"CDD"
] | [
"MF_00135",
"PF00697",
"cd00405"
] | [
"PRAI",
"PRAI",
"PRAI"
] | [
23739,
24317,
23593
] | 3 | [
"EC",
"GP",
"GP"
] | [
"5.3.1.24",
"GenProp0037",
"GenProp1450"
] | [
"EC:5.3.1.24",
"GP:GenProp0037",
"GP:GenProp1450"
] | 3 | [
"1dl3",
"1lbm",
"1nsj",
"1pii",
"1v5x",
"2kzh",
"4aaj",
"4wui",
"5lhe",
"5lhf",
"7etx",
"7ety"
] | 12 | [
"PUB00006375",
"PUB00006524"
] | [
"9166771",
"10745009"
] | [
"Crystal structure at 2.0 A resolution of phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga maritima: possible determinants of protein stability.",
"Structure and function of mutationally generated monomers of dimeric phosphoribosylanthranilate isomerase from Thermotoga maritima."
] | [
1997,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"minichromosomes",
"unclassified sequences"
] | [
761,
20212,
2946,
4,
406
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
31,
1,
1,
3,
1,
1,
12
] | 7 | true | Domain | N-(5'phosphoribosyl) anthranilate isomerase (PRAI) domain | N-(5'phosphoribosyl) anthranilate isomerase (PRAI) domain | PRAI_dom | 8 |
IPR001241 | 1,241 | DNA topoisomerase, type IIA | Topo_IIA | Family | 76,316 | false | false | Type IIA topoisomerases together manage chromosome integrity and topology in cells. Topoisomerase II (called gyrase in bacteria) primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II consists of two polypeptide subunits, gyrA and gyrB, which form a heterotetramer: (BA)2. In most eukaryotes, t... | [
"GO:0003677",
"GO:0003918",
"GO:0005524",
"GO:0006265"
] | [
"DNA binding",
"DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity",
"ATP binding",
"DNA topological change"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 4 | [
"SMART"
] | [
"SM00433"
] | [
"TOP2c"
] | [
76316
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.6.2.2",
"PDOC00160",
"R-CEL-4615885",
"R-DDI-4615885",
"R-DME-4615885",
"R-HSA-1362277",
"R-HSA-4615885",
"R-HSA-9638771",
"R-HSA-9913143",
"R-MMU-4615885",
"R-RNO-4615885",
"R-SCE-4615885",
"R-SPO-4615885",
"R-SSC-4615885"
] | [
"EC:5.6.2.2",
"PROSITEDOC:PDOC00160",
"REACTOME:R-CEL-4615885",
"REACTOME:R-DDI-4615885",
"REACTOME:R-DME-4615885",
"REACTOME:R-HSA-1362277",
"REACTOME:R-HSA-4615885",
"REACTOME:R-HSA-9638771",
"REACTOME:R-HSA-9913143",
"REACTOME:R-MMU-4615885",
"REACTOME:R-RNO-4615885",
"REACTOME:R-SCE-461588... | 14 | [
"1aj6",
"1bgw",
"1bjt",
"1ei1",
"1kij",
"1kzn",
"1pvg",
"1qzr",
"1s16",
"1zxm",
"1zxn",
"2rgr",
"2xco",
"2xcq",
"2xcr",
"2xcs",
"2xct",
"2xkj",
"2xkk",
"2zjt",
"3foe",
"3fof",
"3fv5",
"3g75",
"3g7b",
"3g7e",
"3ig0",
"3k9f",
"3ksa",
"3ksb",
"3l4j",
"3l4k"... | 307 | [
"PUB00005437",
"PUB00016842",
"PUB00020793",
"PUB00020794",
"PUB00020795",
"PUB00020802",
"PUB00020803"
] | [
"7770916",
"11395412",
"12596227",
"12042765",
"7980433",
"16023670",
"8982450"
] | [
"The mechanisms of DNA topoisomerases.",
"DNA topoisomerases: structure, function, and mechanism.",
"Phylogenomics of type II DNA topoisomerases.",
"Cellular roles of DNA topoisomerases: a molecular perspective.",
"Structure and function of type II DNA topoisomerases.",
"The structural basis for substrate... | [
1995,
2001,
2003,
2002,
1994,
2005,
1996
] | 7 | [] | [
"IPR000565",
"IPR001154",
"IPR005737"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
583,
64370,
9360,
721,
1282
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
22,
4,
5,
1,
2,
8,
6,
2,
8,
7,
1,
1,
60
] | 13 | true | Family | DNA topoisomerase, type IIA | DNA topoisomerase, type IIA | Topo_IIA | 5 |
IPR001242 | 1,242 | Condensation domain | Condensation_dom | Domain | 97,032 | false | false | This domain is found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found on the carboxy side of a phosphopantetheine binding domain (pp-binding) ( ). This domain was described as... | [
"GO:0003824"
] | [
"catalytic activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00668"
] | [
"Condensation"
] | [
97032
] | 1 | [
"EC"
] | [
"6.3.2"
] | [
"EC:6.3.2"
] | 1 | [
"1l5a",
"2jgp",
"2vsq",
"2xhg",
"4hvm",
"4jn3",
"4jn5",
"4tx2",
"4tx3",
"4znm",
"4zxh",
"4zxi",
"4zxw",
"5dij",
"5dlk",
"5du9",
"5dua",
"5egf",
"5ejd",
"5isw",
"5isx",
"5ja1",
"5ja2",
"5t3d",
"5t3e",
"5t7z",
"5t81",
"5u89",
"6ad3",
"6aef",
"6cgo",
"6lta"... | 97 | [
"PUB00007135",
"PUB00095150"
] | [
"9712910",
"28526268"
] | [
"Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain.",
"Structural and functional aspects of the nonribosomal peptide synthetase condensation domain superfamily: discovery, dissection and diversity."
] | [
1998,
2017
] | 2 | [] | [
"IPR057737"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimiviridae",
"unclassified sequences"
] | [
80,
78400,
18387,
5,
160
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
1,
3,
2
] | 5 | true | Domain | Condensation domain | Condensation domain | Condensation_dom | 5 |
IPR001245 | 1,245 | Serine-threonine/tyrosine-protein kinase, catalytic domain | Ser-Thr/Tyr_kinase_cat_dom | Domain | 611,269 | false | false | This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include catalytic domain of dual specificity kinases. Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphopr... | [
"GO:0004672",
"GO:0006468"
] | [
"protein kinase activity",
"protein phosphorylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PRINTS"
] | [
"PF07714",
"PR00109"
] | [
"PK_Tyr_Ser-Thr",
"TYRKINASE"
] | [
600367,
206206
] | 2 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp1455",
"R-BTA-114604",
"R-BTA-1227986",
"R-BTA-1257604",
"R-BTA-1433557",
"R-BTA-1433559",
"R-BTA-168638",
"R-BTA-180292",
"R-BTA-202424",
"R-BTA-202427",
"R-BTA-202670",
"R-BTA-202733",
"R-BTA-2029481",
"R-BTA-209543",
"R-BTA-210990",
"R-BTA-210993",
"R-BTA-2424491",
"R-BT... | [
"GP:GenProp1455",
"REACTOME:R-BTA-114604",
"REACTOME:R-BTA-1227986",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-1433557",
"REACTOME:R-BTA-1433559",
"REACTOME:R-BTA-168638",
"REACTOME:R-BTA-180292",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-202427",
"REACTOME:R-BTA-202670",
"REACTOME:R-BTA-202733... | 1,587 | [
"1ad5",
"1agw",
"1byg",
"1fgi",
"1fgk",
"1fmk",
"1fpu",
"1fvr",
"1gag",
"1gjo",
"1i44",
"1iep",
"1ir3",
"1irk",
"1jpa",
"1jqh",
"1k2p",
"1k3a",
"1k9a",
"1ksw",
"1luf",
"1m14",
"1m17",
"1m52",
"1m7n",
"1mp8",
"1mqb",
"1oec",
"1opj",
"1opk",
"1opl",
"1p14"... | 2,723 | [
"PUB00005115",
"PUB00015362",
"PUB00020114",
"PUB00034898",
"PUB00034899"
] | [
"3291115",
"12368087",
"12471243",
"15078142",
"15320712"
] | [
"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.",
"Evolution of protein kinase signaling from yeast to man.",
"The protein kinase complement of the human genome.",
"High-throughput structural biology in drug discovery: protein kinases.",
"Creating chemical dive... | [
1988,
2002,
2002,
2004,
2004
] | 5 | [
"IPR000719"
] | [
"IPR020635",
"IPR035692",
"IPR042817",
"IPR042822"
] | 1 | 4 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"Viruses",
"unclassified sequences"
] | [
3315,
607601,
19,
269,
65
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
2403,
177,
817,
420,
777,
462,
1,
1980,
617,
1,
2886
] | 11 | true | Domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | Ser-Thr/Tyr_kinase_cat_dom | 7 |
IPR001246 | 1,246 | Lipoxygenase, plant | LipOase_plant | Family | 8,333 | false | false | Lipoxygenases ([ec:1.13.11.-]) are a class of iron-containing dioxygenases which catalyses the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure. They are common in plants where they may be involved in a number of diverse aspects of plant physiology including growth and development, pest resist... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR00468"
] | [
"PLTLPOXGNASE"
] | [
8333
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.13.11.58",
"PWY-5406",
"PWY-5407",
"PWY-5408",
"PWY-6917",
"PWY-8395",
"PWY-8398"
] | [
"EC:1.13.11.58",
"METACYC:PWY-5406",
"METACYC:PWY-5407",
"METACYC:PWY-5408",
"METACYC:PWY-6917",
"METACYC:PWY-8395",
"METACYC:PWY-8398"
] | 7 | [
"1f8n",
"1fgm",
"1fgo",
"1fgq",
"1fgr",
"1fgt",
"1hu9",
"1ik3",
"1jnq",
"1lnh",
"1n8q",
"1no3",
"1rov",
"1rrh",
"1rrl",
"1y4k",
"1yge",
"2iuj",
"2iuk",
"2sbl",
"3bnb",
"3bnc",
"3bnd",
"3bne",
"3pzw",
"4wfo",
"4wha",
"5eeo",
"5t5v",
"5tqn",
"5tqo",
"5tqp"... | 38 | [
"PUB00092509"
] | [
"18949503"
] | [
"Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana."
] | [
2009
] | 1 | [
"IPR000907"
] | [] | 1 | 0 | 1 | [
"Viridiplantae"
] | [
8333
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
29,
51,
117
] | 3 | true | Family | Lipoxygenase, plant | Lipoxygenase, plant | LipOase_plant | 5 |
IPR001247 | 1,247 | Exoribonuclease, phosphorolytic domain 1 | ExoRNase_PH_dom1 | Domain | 73,243 | false | false | This entry represents the phosphorolytic (PH) domain 1, which has a core 2-layer α/β structure with a left-handed crossover, similar to that found in ribosomal protein S5. This domain is found in bacterial/organelle PNPases and in archaeal/eukaryotic exosomes [ ]. The PH (phosphorolytic) domain is responsible for 3'-5'... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01138"
] | [
"RNase_PH"
] | [
73243
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.7.8",
"R-BTA-429958",
"R-BTA-450385",
"R-BTA-450513",
"R-BTA-450604",
"R-BTA-6791226",
"R-BTA-9930044",
"R-CEL-429958",
"R-CEL-450385",
"R-CEL-450513",
"R-CEL-6791226",
"R-CEL-9930044",
"R-DDI-429958",
"R-DDI-450385",
"R-DDI-450513",
"R-DDI-6791226",
"R-HSA-380994",
"R-HSA-429... | [
"EC:2.7.7.8",
"REACTOME:R-BTA-429958",
"REACTOME:R-BTA-450385",
"REACTOME:R-BTA-450513",
"REACTOME:R-BTA-450604",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-9930044",
"REACTOME:R-CEL-429958",
"REACTOME:R-CEL-450385",
"REACTOME:R-CEL-450513",
"REACTOME:R-CEL-6791226",
"REACTOME:R-CEL-9930044",
... | 47 | [
"1e3h",
"1e3p",
"1oyp",
"1oyr",
"1oys",
"1r6l",
"1r6m",
"1udn",
"1udo",
"1udq",
"1uds",
"2ba0",
"2ba1",
"2br2",
"2c37",
"2c38",
"2c39",
"2je6",
"2jea",
"2jeb",
"2nn6",
"2pnz",
"2po0",
"2po1",
"2po2",
"2wnr",
"2wp8",
"3b4t",
"3cdi",
"3cdj",
"3dd6",
"3gcm"... | 94 | [
"PUB00000954",
"PUB00035567",
"PUB00035568",
"PUB00035569",
"PUB00035570",
"PUB00035571",
"PUB00035572"
] | [
"9390555",
"17084501",
"15951817",
"17174896",
"16285927",
"16713559",
"17380186"
] | [
"The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases.",
"Genetic analysis of polynucleotide phosphorylase structure and functions.",
"The archaeal exosome core is a hexameric ring structure with three catalytic subunits.",
"Reconstitution, activities, and st... | [
1997,
2007,
2005,
2006,
2005,
2006,
2007
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ct2798",
"unclassified sequences"
] | [
1057,
42320,
28777,
1,
1088
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
44,
7,
8,
12,
2,
28,
26,
5,
26,
30,
5,
6,
84
] | 13 | true | Domain | Exoribonuclease, phosphorolytic domain 1 | Exoribonuclease, phosphorolytic domain 1 | ExoRNase_PH_dom1 | 6 |
IPR001248 | 1,248 | Purine-cytosine permease | Pur-cyt_permease | Family | 44,175 | false | false | This entry represents the purine-cytosine permease family, whose members include allantoin permease Dal4 [ ], nicotinamide riboside transporter 1 (Nrt1) [ ], purine-cytosine permease Fcy2/21/22 [ ], thiamine transporter Thi7/Thi72 [ ], uracil permease Fur4 [ ], uridine permease Fui1 [ ] and vitamin B6 transporter Tpn1 ... | [
"GO:0022857",
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transporter activity",
"transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF02133"
] | [
"Transp_cyt_pur"
] | [
44175
] | 1 | [] | [] | [] | 0 | [
"2jln",
"2x79",
"4d1a",
"4d1b",
"4d1c",
"4d1d",
"7qoa"
] | 7 | [
"PUB00071844",
"PUB00071893",
"PUB00074910",
"PUB00074911",
"PUB00074912",
"PUB00074913",
"PUB00074914",
"PUB00074915",
"PUB00074916"
] | [
"12649274",
"1640834",
"24621654",
"1293888",
"18258590",
"9092500",
"9358046",
"9829833",
"16854981"
] | [
"Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae.",
"Characterization of the Escherichia coli codBA operon encoding cytosine permease and cytosine deaminase.",
"Structure-function relationship of a plant NCS1 member--homology modeling and mutagenesis identified residues critical fo... | [
2003,
1992,
2014,
1992,
2008,
1997,
1997,
1998,
2006
] | 9 | [] | [
"IPR012732",
"IPR026030",
"IPR030191",
"IPR045225"
] | 0 | 4 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
304,
28302,
15307,
262
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
4,
2,
3,
3,
10,
3,
2
] | 7 | true | Family | Purine-cytosine permease | Purine-cytosine permease | Pur-cyt_permease | 9 |
IPR001249 | 1,249 | Acetyl-CoA biotin carboxyl carrier | AcCoA_biotinCC | Family | 21,879 | false | false | The proteins in this family are a component of the acetyl coenzyme A carboxylase complex ( ) and are involved in the first step in long-chain fatty acid synthesis. In plants this is usually located in the chloroplast. In the first step, biotin carboxylase catalyses the carboxylation of the carrier protein to form an in... | [
"GO:0003989",
"GO:0006633",
"GO:0009317"
] | [
"acetyl-CoA carboxylase activity",
"fatty acid biosynthetic process",
"acetyl-CoA carboxylase complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS",
"NCBIFAM"
] | [
"PR01071",
"TIGR00531"
] | [
"ACOABIOTINCC",
"BCCP"
] | [
21753,
18458
] | 2 | [
"GP",
"GP"
] | [
"GenProp0214",
"GenProp1111"
] | [
"GP:GenProp0214",
"GP:GenProp1111"
] | 2 | [
"1a6x",
"1bdo",
"2bdo",
"3bdo",
"4hr7",
"8uxz",
"8uz2",
"9e4n",
"9e4o"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
20019,
1551,
38,
271
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
8,
1
] | 2 | true | Family | Acetyl-CoA biotin carboxyl carrier | Acetyl-CoA biotin carboxyl carrier | AcCoA_biotinCC | 6 |
IPR001251 | 1,251 | CRAL-TRIO lipid binding domain | CRAL-TRIO_dom | Domain | 99,829 | false | false | The CRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules [ ]. The domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor. The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a ... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PROFILE",
"SMART",
"CDD"
] | [
"PF00650",
"PF13716",
"PS50191",
"SM00516",
"cd00170"
] | [
"CRAL_TRIO",
"CRAL_TRIO_2",
"CRAL_TRIO",
"SEC14",
"SEC14"
] | [
67941,
30497,
89834,
82817,
92343
] | 5 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50191",
"R-BTA-2187335",
"R-BTA-2453902",
"R-DDI-2187335",
"R-DDI-2453902",
"R-DDI-432720",
"R-DDI-5658442",
"R-DDI-8877627",
"R-DME-8877627",
"R-DME-8980692",
"R-DME-9013026",
"R-DME-9013148",
"R-DME-9013149",
"R-DME-9013404",
"R-DME-9013405",
"R-DME-9013406",
"R-DME-9013408",
... | [
"PROSITEDOC:PDOC50191",
"REACTOME:R-BTA-2187335",
"REACTOME:R-BTA-2453902",
"REACTOME:R-DDI-2187335",
"REACTOME:R-DDI-2453902",
"REACTOME:R-DDI-432720",
"REACTOME:R-DDI-5658442",
"REACTOME:R-DDI-8877627",
"REACTOME:R-DME-8877627",
"REACTOME:R-DME-8980692",
"REACTOME:R-DME-9013026",
"REACTOME:R... | 114 | [
"1aua",
"1o6u",
"1oip",
"1oiz",
"1olm",
"1r5l",
"2d4q",
"2e2x",
"3b74",
"3b7n",
"3b7q",
"3b7z",
"3hx3",
"3hy5",
"3p7z",
"3peg",
"3pg7",
"3q8g",
"3w67",
"3w68",
"4ciz",
"4cj6",
"4fmm",
"4j7p",
"4j7q",
"4m8z",
"4omj",
"4omk",
"4tlg",
"4uyb",
"5mue",
"5mug"... | 70 | [
"PUB00002798",
"PUB00004273",
"PUB00018188",
"PUB00018190",
"PUB00056878",
"PUB00093503",
"PUB00163288",
"PUB00163289"
] | [
"8349655",
"9461221",
"2198263",
"10829015",
"12767229",
"10848624",
"12869188",
"16709158"
] | [
"Primary structure of alpha-tocopherol transfer protein from rat liver. Homology with cellular retinaldehyde-binding protein.",
"Crystal structure of the Saccharomyces cerevisiae phosphatidylinositol-transfer protein.",
"Cloning and characterization of Kluyveromyces lactis SEC14, a gene whose product stimulates... | [
1993,
1998,
1990,
2000,
2003,
2000,
2003,
2006
] | 8 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
12,
381,
99344,
5,
87
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
189,
20,
248,
79,
127,
79,
7,
99,
118,
7,
6,
383
] | 12 | true | Domain | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain | CRAL-TRIO_dom | 8 |
IPR001252 | 1,252 | Malate dehydrogenase, active site | Malate_DH_AS | Active_site | 28,185 | false | false | Malate dehydrogenase ( ) (MDH) [ ] catalyzes the interconversion of malate to oxaloacetate utilizing the NAD/NADH cofactor system. The enzyme participates in the citric acid cycle and exists in all aerobics organisms. While prokaryotic organisms contains a single form of MDH, in eukaryotic cells there are two isozymes:... | [
"GO:0016615",
"GO:0006108"
] | [
"malate dehydrogenase activity",
"malate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS00068"
] | [
"MDH"
] | [
28185
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTO... | [
"1.1.1.37",
"PWY-1622",
"PWY-5392",
"PWY-561",
"PWY-5690",
"PWY-6728",
"PWY-6969",
"PWY-7115",
"PWY-7383",
"PWY-8086",
"PDOC00066",
"R-BTA-71403",
"R-BTA-9837999",
"R-BTA-9856872",
"R-CEL-71403",
"R-CEL-9837999",
"R-CEL-9856872",
"R-DDI-9856872",
"R-GGA-352875",
"R-HSA-71403",
... | [
"EC:1.1.1.37",
"METACYC:PWY-1622",
"METACYC:PWY-5392",
"METACYC:PWY-561",
"METACYC:PWY-5690",
"METACYC:PWY-6728",
"METACYC:PWY-6969",
"METACYC:PWY-7115",
"METACYC:PWY-7383",
"METACYC:PWY-8086",
"PROSITEDOC:PDOC00066",
"REACTOME:R-BTA-71403",
"REACTOME:R-BTA-9837999",
"REACTOME:R-BTA-985687... | 33 | [
"1bdm",
"1bmd",
"1civ",
"1emd",
"1iz9",
"1mld",
"1sev",
"1smk",
"1wze",
"1wzi",
"1y7t",
"2cmd",
"2cvq",
"2dfd",
"2pwz",
"3hhp",
"4e0b",
"4h7p",
"4i1i",
"4kde",
"4kdf",
"4mdh",
"4tvo",
"4uup",
"4wle",
"4wlf",
"4wln",
"4wlo",
"4wlu",
"4wlv",
"5kka",
"5kvv"... | 57 | [
"PUB00000309",
"PUB00000626"
] | [
"2775751",
"1610875"
] | [
"Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution.",
"Malate dehydrogenase isoenzymes: cellular locations and role in the flow of metabolites between the cytoplasm and cell organelles."
] | [
1989,
1992
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes",
"unclassified Candidatus Thermoprofundales"
] | [
9283,
2,
18804,
91,
5
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
44,
2,
11,
7,
2,
12,
5,
2,
24,
9,
3,
57
] | 12 | true | Active_site | Malate dehydrogenase, active site | Malate dehydrogenase, active site | Malate_DH_AS | 8 |
IPR001253 | 1,253 | Translation initiation factor 1A (eIF-1A) | TIF_eIF-1A | Family | 11,454 | false | false | Eukaryotic translation initiation factor A (eIF-1A) (formerly known as eiF-4C) is a protein that seems to be required for maximal rate of protein biosynthesis. It enhances ribosome dissociation into subunits and stabilises the binding of the initiator Met-tRNA to 40S ribosomal subunits [ ]. The archaea possess an eIF-1... | [
"GO:0003743",
"GO:0006413"
] | [
"translation initiation factor activity",
"translational initiation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PANTHER",
"SMART",
"NCBIFAM",
"CDD"
] | [
"MF_00216",
"PTHR21668",
"SM00652",
"TIGR00523",
"cd05793"
] | [
"aIF_1A",
"",
"eIF1a",
"eIF-1A",
"S1_IF1A"
] | [
7402,
8084,
11354,
6550,
7743
] | 5 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00970",
"R-DDI-156827",
"R-DDI-72689",
"R-DDI-72695",
"R-DDI-72702",
"R-HSA-156827",
"R-HSA-72649",
"R-HSA-72689",
"R-HSA-72695",
"R-HSA-72702",
"R-HSA-72706",
"R-MMU-156827",
"R-MMU-72649",
"R-MMU-72689",
"R-MMU-72695",
"R-MMU-72702",
"R-MMU-72706",
"R-RNO-156827",
"R-RNO-7... | [
"PROSITEDOC:PDOC00970",
"REACTOME:R-DDI-156827",
"REACTOME:R-DDI-72689",
"REACTOME:R-DDI-72695",
"REACTOME:R-DDI-72702",
"REACTOME:R-HSA-156827",
"REACTOME:R-HSA-72649",
"REACTOME:R-HSA-72689",
"REACTOME:R-HSA-72695",
"REACTOME:R-HSA-72702",
"REACTOME:R-HSA-72706",
"REACTOME:R-MMU-156827",
"... | 33 | [
"1d7q",
"1jt8",
"2dgy",
"2oqk",
"3j80",
"3j81",
"3jam",
"3jap",
"3wbk",
"3zjy",
"4bts",
"4kzy",
"4kzz",
"4mno",
"4uer",
"5jb3",
"5jbh",
"6fyx",
"6fyy",
"6gsm",
"6gsn",
"6sw9",
"6swc",
"6swd",
"6swe",
"6yal",
"6yam",
"6ybw",
"6zce",
"6zmw",
"6zp4",
"6zu9"... | 71 | [
"PUB00002919"
] | [
"7559407"
] | [
"Characterization of yeast translation initiation factor 1A and cloning of its essential gene."
] | [
1995
] | 1 | [] | [
"IPR039294"
] | 0 | 1 | 0 | [
"Archaea",
"Eukaryota",
"Pseudomonadati",
"Viruses",
"metagenomes"
] | [
1404,
9798,
36,
25,
191
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
2,
3,
4,
10,
21,
2,
6,
11,
1,
2,
13
] | 12 | true | Family | Translation initiation factor 1A (eIF-1A) | Translation initiation factor 1A (eIF-1A) | TIF_eIF-1A | 9 |
IPR001254 | 1,254 | Serine proteases, trypsin domain | Trypsin_dom | Domain | 216,831 | false | false | This entry represents the active-site-containing domain found in the trypsin family members. The catalytic activity of the serine proteases from the trypsin family is provided by a charge relay system involving an aspartic acid residue hydrogen-bonded to a histidine, which itself is hydrogen-bonded to a serine. The seq... | [
"GO:0004252",
"GO:0006508"
] | [
"serine-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART",
"CDD"
] | [
"PF00089",
"PS50240",
"SM00020",
"cd00190"
] | [
"Trypsin",
"TRYPSIN_DOM",
"Tryp_SPc",
"Tryp_SPc"
] | [
215204,
196145,
187591,
163089
] | 4 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.21",
"PDOC00124",
"R-BTA-114608",
"R-BTA-140834",
"R-BTA-140837",
"R-BTA-1592389",
"R-BTA-159740",
"R-BTA-159763",
"R-BTA-159782",
"R-BTA-166663",
"R-BTA-173736",
"R-BTA-174577",
"R-BTA-381426",
"R-BTA-6798695",
"R-BTA-75205",
"R-BTA-8957275",
"R-BTA-977606",
"R-CFA-114608",
... | [
"EC:3.4.21",
"PROSITEDOC:PDOC00124",
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-140834",
"REACTOME:R-BTA-140837",
"REACTOME:R-BTA-1592389",
"REACTOME:R-BTA-159740",
"REACTOME:R-BTA-159763",
"REACTOME:R-BTA-159782",
"REACTOME:R-BTA-166663",
"REACTOME:R-BTA-173736",
"REACTOME:R-BTA-174577",
"REA... | 249 | [
"1a0h",
"1a0j",
"1a0l",
"1a2c",
"1a3b",
"1a3e",
"1a46",
"1a4w",
"1a5g",
"1a5h",
"1a5i",
"1a61",
"1a7s",
"1ab9",
"1abi",
"1abj",
"1acb",
"1ad8",
"1ae5",
"1ae8",
"1afe",
"1afq",
"1aht",
"1ai8",
"1aix",
"1aks",
"1amh",
"1an1",
"1anb",
"1anc",
"1and",
"1ane"... | 2,701 | [
"PUB00003576",
"PUB00004028"
] | [
"7845208",
"3136396"
] | [
"Families of serine peptidases.",
"The molecular evolution of genes and proteins: a tale of two serines."
] | [
1994,
1988
] | 2 | [] | [
"IPR015420"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
34,
24439,
192124,
33,
201
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
1,
15,
297,
601,
1,
612,
419,
1,
590,
2
] | 10 | true | Domain | Serine proteases, trypsin domain | Serine proteases, trypsin domain | Trypsin_dom | 8 |
IPR001256 | 1,256 | GPCR, family 3, metabotropic glutamate receptor 1 | GPCR_3_mGluR1 | Family | 1,581 | false | false | The mRNA for GRM1 is widespread in the brain and is abundant in neuronal cells in hippocampal dentate gyrus and CA2-3 regions, cerebellum Purkinje cells, olfactory bulb and thalamic nuclei. GRM1 activates the phosphoinositide pathway. It is thought to participate in the central action of glutamate in the CNS, such as l... | [
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01051"
] | [
"MTABOTROPC1R"
] | [
1581
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"289",
"R-HSA-416476",
"R-HSA-420499",
"R-HSA-6794361",
"R-HSA-9717207",
"R-MMU-416476",
"R-MMU-420499",
"R-MMU-6794361",
"R-RNO-416476",
"R-RNO-420499",
"R-RNO-6794361"
] | [
"IUPHAR:289",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-420499",
"REACTOME:R-HSA-6794361",
"REACTOME:R-HSA-9717207",
"REACTOME:R-MMU-416476",
"REACTOME:R-MMU-420499",
"REACTOME:R-MMU-6794361",
"REACTOME:R-RNO-416476",
"REACTOME:R-RNO-420499",
"REACTOME:R-RNO-6794361"
] | 11 | [
"1ewk",
"1ewt",
"1ewv",
"1isr",
"1iss",
"3ks9",
"7dgd",
"7dge"
] | 8 | [
"PUB00002720",
"PUB00004090",
"PUB00004161",
"PUB00004309",
"PUB00004961",
"PUB00005138",
"PUB00007343",
"PUB00036049",
"PUB00036050",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00100438",
"PUB00100439",
"PUB00100440",
"PUB001004... | [
"1320017",
"1847995",
"8255296",
"1309649",
"8170923",
"1656524",
"9292726",
"17266540",
"10773016",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"7476890",
"28886343",
"24603153",
"20055706"
] | [
"Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.",
"Sequence and expression of a metabotropic glutamate receptor.",
"Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.",
"A famil... | [
1992,
1991,
1993,
1992,
1994,
1991,
1997,
2007,
2000,
2003,
1994,
2005,
2009,
2006,
2013,
1995,
2017,
2014,
2010
] | 19 | [
"IPR000162"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
1581
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
2,
4
] | 4 | true | Family | GPCR, family 3, metabotropic glutamate receptor 1 | GPCR, family 3, metabotropic glutamate receptor 1 | GPCR_3_mGluR1 | 1 |
IPR001257 | 1,257 | Parvovirus non-structural protein 1, helicase domain | Parvovirus_NS1_helicase | Domain | 4,607 | false | false | Parvoviruses are some of the smallest viruses containing linear, non-segmented single-stranded DNA genomes, with an average genome size of 5000 nucleotides. Parvoviruses have been described that infect a wide range of invertebrates and vertebrates and are well known for causing enteric disease in mammals. Genomes conta... | [
"GO:0019079"
] | [
"viral genome replication"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF01057"
] | [
"Parvo_NS1"
] | [
4607
] | 1 | [
"EC",
"EC"
] | [
"3.1.21.-",
"3.6.4.12"
] | [
"EC:3.1.21.-",
"EC:3.6.4.12"
] | 2 | [
"1s9h",
"1u0j",
"3p0s",
"7jse",
"7jsf",
"7jsg",
"7jsh",
"7jsi",
"9bc5",
"9bu7",
"9kbg",
"9kbh",
"9kbi",
"9kbj"
] | 14 | [
"PUB00005594",
"PUB00053332",
"PUB00054921",
"PUB00096898"
] | [
"8372437",
"15994782",
"20097398",
"12050365"
] | [
"Nuclear targeting of the parvoviral replicator molecule NS1: evidence for self-association prior to nuclear transport.",
"Parvovirus nonstructural proteins induce an epigenetic modification through histone acetylation in host genes and revert tumor malignancy to benignancy.",
"Determination and analysis of the... | [
1993,
2005,
2010,
2002
] | 4 | [
"IPR014015"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
8,
317,
4280,
2
] | 4 | [
"Homo sapiens"
] | [
1
] | 1 | true | Domain | Parvovirus non-structural protein 1, helicase domain | Parvovirus non-structural protein 1, helicase domain | Parvovirus_NS1_helicase | 5 |
IPR001258 | 1,258 | NHL repeat | NHL_repeat | Repeat | 60,049 | false | false | The NHL repeat, named after NCL-1, HT2A and Lin-41, is a conserved structural motif present in a large number of eukaryotic and prokaryotic proteins. For example, the repeat is found in a variety of enzymes of the copper type II, ascorbate-dependent monooxygenase family, which catalyse the C-terminal alpha-amidation of... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE"
] | [
"PF01436",
"PS51125"
] | [
"NHL",
"NHL"
] | [
52390,
51801
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-114608",
"R-CEL-6798695",
"R-DME-6798695",
"R-DRE-983168",
"R-HSA-114608",
"R-HSA-3134975",
"R-HSA-3322077",
"R-HSA-3785653",
"R-HSA-6798695",
"R-HSA-877300",
"R-HSA-983168",
"R-MMU-114608",
"R-MMU-3134975",
"R-MMU-6798695",
"R-MMU-983168",
"R-RNO-983168"
] | [
"REACTOME:R-BTA-114608",
"REACTOME:R-CEL-6798695",
"REACTOME:R-DME-6798695",
"REACTOME:R-DRE-983168",
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-3134975",
"REACTOME:R-HSA-3322077",
"REACTOME:R-HSA-3785653",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-877300",
"REACTOME:R-HSA-983168",
"REACTOME:R-M... | 16 | [
"1q7f",
"1rwi",
"1rwl",
"3fvz",
"3fw0",
"3ww7",
"3ww8",
"3ww9",
"3wwa",
"3wwb",
"3wwf",
"4zcn",
"4zlr",
"5chb",
"5ex7",
"5f53",
"5i1y",
"5i1z",
"5wm0",
"6d69",
"6f0q",
"6f0s",
"6f0t",
"6fpt",
"6fq3",
"6fql",
"6g7w",
"6gc1",
"6i37",
"6i38",
"6i39",
"6i3a"... | 72 | [
"PUB00002654",
"PUB00005488",
"PUB00017037",
"PUB00020208",
"PUB00030819"
] | [
"1894599",
"9868369",
"14561773",
"11336677",
"15136047"
] | [
"The membrane-bound bifunctional peptidylglycine alpha-amidating monooxygenase protein. Exploration of its domain structure through limited proteolysis.",
"A novel repeat domain that is often associated with RING finger and B-box motifs.",
"Model of the brain tumor-Pumilio translation repressor complex.",
"St... | [
1991,
1998,
2003,
2001,
2004
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
229,
11849,
47100,
2,
869
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
43,
21,
26,
23,
55,
27,
7,
32,
22
] | 9 | true | Repeat | NHL repeat | NHL repeat | NHL_repeat | 5 |
IPR001259 | 1,259 | Proteinase inhibitor I27, calpastatin | Prot_inh_calpain | Repeat | 3,094 | false | false | This entry represents repeats on calpain inhibitor proteins. Calpain inhibitor (calpastatin) is restricted to the metazoa and specifically inhibits calpain (calcium-dependent cysteine protease) [ ]. Calpastatin belongs to MEROPS inhibitor family I27, clan II. It plays a key role in post-mortem tenderisation of meat and... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00748"
] | [
"Calpain_inhib"
] | [
3094
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1474228",
"R-HSA-8862803",
"R-MMU-1474228",
"R-RNO-1474228",
"R-SSC-1474228"
] | [
"REACTOME:R-HSA-1474228",
"REACTOME:R-HSA-8862803",
"REACTOME:R-MMU-1474228",
"REACTOME:R-RNO-1474228",
"REACTOME:R-SSC-1474228"
] | 5 | [
"3bow",
"3df0"
] | 2 | [
"PUB00014535",
"PUB00062143"
] | [
"12843408",
"15255177"
] | [
"The calpain system.",
"Interaction of calpastatin with calpain: a review."
] | [
2003,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
3094
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
53,
42,
10,
15
] | 4 | true | Repeat | Proteinase inhibitor I27, calpastatin | Proteinase inhibitor I27, calpastatin | Prot_inh_calpain | 8 |
IPR001260 | 1,260 | Coproporphyrinogen III oxidase, aerobic | Coprogen_oxidase_aer | Family | 17,190 | false | false | Coprogen oxidase (i.e. coproporphyrin III oxidase or coproporphyrinogenase) catalyses the oxidative decarboxylation of coproporphyrinogen III to proto-porhyrinogen IX in the haem and chlorophyll biosynthetic pathways [ , ]. The protein is a homodimer containing two internally bound iron atoms per molecule of native pro... | [
"GO:0004109",
"GO:0006779"
] | [
"coproporphyrinogen oxidase activity",
"porphyrin-containing compound biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PFAM",
"PIRSF",
"PRINTS",
"PANTHER"
] | [
"MF_00333",
"PF01218",
"PIRSF000166",
"PR00073",
"PTHR10755"
] | [
"Coprogen_oxidas",
"Coprogen_oxidas",
"Coproporphyri_ox",
"COPRGNOXDASE",
""
] | [
8181,
17185,
14239,
16797,
17123
] | 5 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.3.3.3",
"GenProp0221",
"GenProp1421",
"GenProp1470",
"PWY-7159",
"PDOC00783",
"R-DDI-189451",
"R-DME-189451",
"R-HSA-189451",
"R-MMU-189451",
"R-RNO-189451",
"R-SCE-189451",
"R-SPO-189451"
] | [
"EC:1.3.3.3",
"GP:GenProp0221",
"GP:GenProp1421",
"GP:GenProp1470",
"METACYC:PWY-7159",
"PROSITEDOC:PDOC00783",
"REACTOME:R-DDI-189451",
"REACTOME:R-DME-189451",
"REACTOME:R-HSA-189451",
"REACTOME:R-MMU-189451",
"REACTOME:R-RNO-189451",
"REACTOME:R-SCE-189451",
"REACTOME:R-SPO-189451"
] | 13 | [
"1tk1",
"1tkl",
"1tlb",
"1txn",
"1vju",
"2aex",
"2qt8",
"3dwr",
"3dws",
"3e8j",
"3ejo",
"5eo6",
"8t7w"
] | 13 | [
"PUB00001344",
"PUB00002804",
"PUB00004565"
] | [
"3516695",
"8407975",
"8219054"
] | [
"Purification and properties of coproporphyrinogen oxidase from the yeast Saccharomyces cerevisiae.",
"Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation.",
"A soybean coproporphyrinogen oxidase gene is highly expressed in root nodules."
] | [
1986,
1993,
1993
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
11948,
5097,
145
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae... | [
7,
1,
2,
1,
2,
2,
1,
3,
3,
1,
1,
8
] | 12 | true | Family | Coproporphyrinogen III oxidase, aerobic | Coproporphyrinogen III oxidase, aerobic | Coprogen_oxidase_aer | 6 |
IPR001261 | 1,261 | ArgE/DapE/ACY1/CPG2/YscS, conserved site | ArgE/DapE_CS | Conserved_site | 74,357 | false | false | This group contains metallopeptidases belonging to MEROPS peptidase family M20 (clan MH), subfamilies M20A and M20B; many are classified as unassigned peptidases or non-peptidase homologues. In addition to the metallopeptidases this group of sequences contain a variety of other protein families from the archaea, bacter... | [] | [] | [] | 0 | [
"PROSITE",
"PROSITE"
] | [
"PS00758",
"PS00759"
] | [
"ARGE_DAPE_CPG2_1",
"ARGE_DAPE_CPG2_2"
] | [
52495,
45722
] | 2 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.1",
"PDOC00613",
"R-BTA-174403",
"R-BTA-9753281",
"R-DDI-5423646",
"R-DDI-9673163",
"R-DDI-9753281",
"R-HSA-174403",
"R-HSA-5423646",
"R-HSA-5579007",
"R-HSA-9753281",
"R-MMU-174403",
"R-MMU-5423646",
"R-MMU-9753281",
"R-RNO-174403",
"R-RNO-5423646",
"R-RNO-9753281",
"R-SCE-96... | [
"EC:3.5.1",
"PROSITEDOC:PDOC00613",
"REACTOME:R-BTA-174403",
"REACTOME:R-BTA-9753281",
"REACTOME:R-DDI-5423646",
"REACTOME:R-DDI-9673163",
"REACTOME:R-DDI-9753281",
"REACTOME:R-HSA-174403",
"REACTOME:R-HSA-5423646",
"REACTOME:R-HSA-5579007",
"REACTOME:R-HSA-9753281",
"REACTOME:R-MMU-174403",
... | 22 | [
"1cg2",
"1fno",
"1lfw",
"1q7l",
"1vix",
"2rb7",
"2zof",
"2zog",
"3ct9",
"3dlj",
"3gb0",
"3ic1",
"3ife",
"3isz",
"3rza",
"3tx8",
"4h2k",
"4onw",
"4op4",
"4q7a",
"4ruh",
"5vo3",
"6xj5",
"7lgp",
"7ljh",
"7lji",
"7m6u",
"7rsf",
"7uoi",
"8uw6",
"8vkt"
] | 31 | [
"PUB00014889"
] | [
"11250542"
] | [
"Sequence analysis of the aminoacylase-1 family. A new proposed signature for metalloexopeptidases."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1477,
57855,
14259,
52,
714
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
14,
7,
7,
3,
4,
22,
12,
3,
4,
17,
2,
1,
10
] | 13 | true | Conserved_site | ArgE/DapE/ACY1/CPG2/YscS, conserved site | ArgE/DapE/ACY1/CPG2/YscS, conserved site | ArgE/DapE_CS | 4 |
IPR001262 | 1,262 | Hyperglycemic hormone type 2 | Hyperglycemic2 | Family | 100 | false | false | Hyperglycemic hormone, which controls blood sugar levels, is an abundant peptide in the sinus glands of isopods and decapods [ , ]. The peptide is a potent secretagogue, releasing digestive enzymes from the hepatopancreas. It may act as a stress hormone. The peptide contains around 70 amino acid residues, and includes ... | [
"GO:0005184",
"GO:0005576"
] | [
"neuropeptide hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR00549"
] | [
"HYPRGLYCEMC2"
] | [
100
] | 1 | [] | [] | [] | 0 | [
"1j0t"
] | 1 | [
"PUB00000190",
"PUB00001435",
"PUB00001577"
] | [
"2169734",
"8436119",
"2792364"
] | [
"Amino acid sequence of a peptide with both molt-inhibiting and hyperglycemic activities in the lobster, Homarus americanus.",
"Isolation and molecular characterization of a hyperglycemic neuropeptide from the sinus gland of the terrestrial isopod Armadillidium vulgare (Crustacea).",
"Amino acid sequence of the... | [
1990,
1993,
1989
] | 3 | [
"IPR001166"
] | [] | 1 | 0 | 1 | [
"Eumalacostraca"
] | [
100
] | 1 | [] | [] | 0 | true | Family | Hyperglycemic hormone type 2 | Hyperglycemic hormone type 2 | Hyperglycemic2 | 5 |
IPR001263 | 1,263 | Phosphoinositide 3-kinase, accessory (PIK) domain | PI3K_accessory_dom | Domain | 26,459 | false | false | Phosphatidylinositol 3-kinase (PI3K) ( ) is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. The role of the accessory domain of phosphoinositide 3-kinase (PI3-kinase) is unclear. It may be involved in substrate presentation [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00613",
"PS51545",
"SM00145"
] | [
"PI3Ka",
"PIK_HELICAL",
"PI3Ka"
] | [
21921,
26099,
21385
] | 3 | [
"EC",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.1",
"GenProp1548",
"GenProp1758",
"R-BTA-109704",
"R-BTA-112399",
"R-BTA-114604",
"R-BTA-1250342",
"R-BTA-1257604",
"R-BTA-1433557",
"R-BTA-1660499",
"R-BTA-180292",
"R-BTA-186763",
"R-BTA-1963642",
"R-BTA-198203",
"R-BTA-201556",
"R-BTA-202424",
"R-BTA-2029485",
"R-BTA-210993... | [
"EC:2.7.1",
"GP:GenProp1548",
"GP:GenProp1758",
"REACTOME:R-BTA-109704",
"REACTOME:R-BTA-112399",
"REACTOME:R-BTA-114604",
"REACTOME:R-BTA-1250342",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-1433557",
"REACTOME:R-BTA-1660499",
"REACTOME:R-BTA-180292",
"REACTOME:R-BTA-186763",
"REACTOME:R-BTA... | 257 | [
"1e7u",
"1e7v",
"1e8w",
"1e8x",
"1e8y",
"1e8z",
"1e90",
"1he8",
"2a4z",
"2a5u",
"2chw",
"2chx",
"2chz",
"2rd0",
"2v4l",
"2wxf",
"2wxg",
"2wxh",
"2wxi",
"2wxj",
"2wxk",
"2wxl",
"2wxm",
"2wxn",
"2wxo",
"2wxp",
"2wxq",
"2wxr",
"2x38",
"2x6f",
"2x6h",
"2x6i"... | 367 | [
"PUB00005173"
] | [
"8248783"
] | [
"Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability."
] | [
1993
] | 1 | [
"IPR049160"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
11,
26437,
9,
2
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
20,
5,
42,
12,
55,
34,
3,
14,
45,
3,
3,
45
] | 12 | true | Domain | Phosphoinositide 3-kinase, accessory (PIK) domain | Phosphoinositide 3-kinase, accessory (PIK) domain | PI3K_accessory_dom | 8 |
IPR001264 | 1,264 | Glycosyl transferase, family 51 | Glyco_trans_51 | Domain | 85,626 | false | false | The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferas... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00912"
] | [
"Transgly"
] | [
85626
] | 1 | [
"CAZY",
"EC",
"REACTOME"
] | [
"GT51",
"2.4.99.28",
"R-HSA-9638771"
] | [
"CAZY:GT51",
"EC:2.4.99.28",
"REACTOME:R-HSA-9638771"
] | 3 | [
"2jch",
"2je5",
"2olu",
"2olv",
"2oqo",
"3d3h",
"3dwk",
"3fwl",
"3hzs",
"3nb6",
"3nb7",
"3udf",
"3udi",
"3udx",
"3ue0",
"3ue1",
"3vma",
"3vmq",
"3vmr",
"3vms",
"3vmt",
"3zg7",
"3zg8",
"3zg9",
"3zga",
"4oon",
"5fgz",
"5hl9",
"5hla",
"5hlb",
"5hld",
"5u2g"... | 42 | [
"PUB00002311",
"PUB00003875",
"PUB00009409"
] | [
"9244263",
"8830253",
"9334165"
] | [
"Topographical and functional investigation of Escherichia coli penicillin-binding protein 1b by alanine stretch scanning mutagenesis.",
"Monofunctional biosynthetic peptidoglycan transglycosylases.",
"A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities.... | [
1997,
1996,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"candidate division MSBL1 archaeon SCGC-AAA382N08",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
84354,
380,
1,
2,
889
] | 5 | [
"Escherichia coli (strain K12)"
] | [
4
] | 1 | true | Domain | Glycosyl transferase, family 51 | Glycosyl transferase, family 51 | Glyco_trans_51 | 5 |
IPR001265 | 1,265 | Formin homology family, Cappuccino subfamily | Formin_Cappuccino_subfam | Family | 2,995 | false | false | Formins (formin homology proteins) proteins play a crucial role in the reorganisation of the actin cytoskeleton and associate with the fast-growing end (barbed end) of actin filaments [ , ]. This entry represents the formin homologues from animals (and some fungi), including protein cappuccino from Drosophila melanogas... | [
"GO:0008017",
"GO:0045010",
"GO:0005884"
] | [
"microtubule binding",
"actin nucleation",
"actin filament"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR00828"
] | [
"FORMIN"
] | [
2995
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00014909",
"PUB00014910",
"PUB00014911",
"PUB00014912",
"PUB00066248",
"PUB00066267"
] | [
"10631086",
"12538772",
"14576350",
"14992721",
"12775772",
"19633175"
] | [
"Formin family proteins in cytoskeletal control.",
"ForC, a novel type of formin family protein lacking an FH1 domain, is involved in multicellular development in Dictyostelium discoideum.",
"Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic comp... | [
2000,
2003,
2003,
2004,
2003,
2009
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2995
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
16,
13,
13,
6,
12
] | 5 | true | Family | Formin homology family, Cappuccino subfamily | Formin homology family, Cappuccino subfamily | Formin_Cappuccino_subfam | 4 |
IPR001267 | 1,267 | Thymidine kinase | Thymidine_kinase | Family | 19,943 | false | false | Thymidine kinase (TK) ( ) is an ubiquitous enzyme that catalyzes the ATP-dependent phosphorylation of thymidine. | [
"GO:0004797",
"GO:0005524"
] | [
"thymidine kinase activity",
"ATP binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"HAMAP",
"PFAM",
"PIRSF",
"PANTHER"
] | [
"MF_00124",
"PF00265",
"PIRSF035805",
"PTHR11441"
] | [
"Thymidine_kinase",
"TK",
"TK_cell",
""
] | [
13127,
19936,
16927,
19516
] | 4 | [
"EC",
"GP",
"GP",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1.21",
"GenProp1221",
"GenProp1264",
"PWY-7199",
"PDOC00524",
"R-DDI-73614",
"R-GGA-73614",
"R-HSA-69205",
"R-HSA-73614",
"R-MMU-73614"
] | [
"EC:2.7.1.21",
"GP:GenProp1221",
"GP:GenProp1264",
"METACYC:PWY-7199",
"PROSITEDOC:PDOC00524",
"REACTOME:R-DDI-73614",
"REACTOME:R-GGA-73614",
"REACTOME:R-HSA-69205",
"REACTOME:R-HSA-73614",
"REACTOME:R-MMU-73614"
] | 10 | [
"1w4r",
"1xbt",
"1xx6",
"2b8t",
"2j87",
"2j9r",
"2ja1",
"2orv",
"2orw",
"2qpo",
"2qq0",
"2qqe",
"2uz3",
"2wvj",
"3e2i",
"4uxh",
"4uxi",
"4uxj",
"5fuv",
"5fuw",
"5fux",
"5fuy",
"8y7w",
"9k6k"
] | 24 | [
"PUB00005563",
"PUB00005572"
] | [
"3027984",
"2389555"
] | [
"Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinases.",
"Sequence and evolutionary relationships of African swine fever virus thymidine kinase."
] | [
1987,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
225,
15282,
3122,
820,
494
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
7,
2,
1,
1,
8,
4,
5,
10,
6
] | 9 | true | Family | Thymidine kinase | Thymidine kinase | Thymidine_kinase | 7 |
IPR001268 | 1,268 | NADH:ubiquinone oxidoreductase, 30kDa subunit | NADH_UbQ_OxRdtase_30kDa_su | Domain | 43,540 | false | false | Respiratory-chain NADH dehydrogenase ( ) (also known as complex I or NADH-ubiquinone oxidoreductase) is an oligomeric enzymatic complex located in the inner mitochondrial membrane which also seems to exist in the chloroplast and in cyanobacteria (as a NADH-plastoquinone oxidoreductase). Among the 25 to 30 polypeptide s... | [
"GO:0008137"
] | [
"NADH dehydrogenase (ubiquinone) activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00329"
] | [
"Complex1_30kDa"
] | [
43540
] | 1 | [
"EC",
"GP",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"7.1.1.-",
"GenProp0135",
"PDOC00468",
"R-DDI-6799198",
"R-DDI-9013408",
"R-DME-611105",
"R-DME-6799198",
"R-DME-9013408",
"R-DME-9837999",
"R-HSA-611105",
"R-HSA-6799198",
"R-HSA-9013408",
"R-HSA-9837999",
"R-MMU-611105",
"R-MMU-6799198",
"R-MMU-9013408",
"R-MMU-9837999"
] | [
"EC:7.1.1.-",
"GP:GenProp0135",
"PROSITEDOC:PDOC00468",
"REACTOME:R-DDI-6799198",
"REACTOME:R-DDI-9013408",
"REACTOME:R-DME-611105",
"REACTOME:R-DME-6799198",
"REACTOME:R-DME-9013408",
"REACTOME:R-DME-9837999",
"REACTOME:R-HSA-611105",
"REACTOME:R-HSA-6799198",
"REACTOME:R-HSA-9013408",
"REA... | 17 | [
"2fug",
"2ybb",
"3i9v",
"3iam",
"3ias",
"3m9s",
"3mcr",
"4hea",
"4wz7",
"5b3p",
"5b3q",
"5gpn",
"5gup",
"5lc5",
"5ldw",
"5ldx",
"5lnk",
"5o31",
"5xtb",
"5xtd",
"5xth",
"5xti",
"6cfw",
"6g2j",
"6g72",
"6gcs",
"6h8k",
"6hum",
"6i0d",
"6i1p",
"6khi",
"6khj"... | 338 | [
"PUB00001392",
"PUB00005074",
"PUB00043561",
"PUB00045437",
"PUB00097437"
] | [
"2029890",
"1470679",
"10940377",
"18394423",
"27398308"
] | [
"The respiratory-chain NADH dehydrogenase (complex I) of mitochondria.",
"The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.",
"The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.",
"Assembly of the Escherichia coli... | [
1991,
1992,
2000,
2008,
2016
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1322,
22193,
19290,
735
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
9,
1,
1,
1,
3,
4,
1,
1,
10,
5,
7
] | 11 | true | Domain | NADH:ubiquinone oxidoreductase, 30kDa subunit | NADH:ubiquinone oxidoreductase, 30kDa subunit | NADH_UbQ_OxRdtase_30kDa_su | 8 |
IPR001269 | 1,269 | tRNA-dihydrouridine synthase | DUS_fam | Family | 42,974 | false | false | Dihydrouridine synthases (Dus) is a large family of flavoenzymes comprising eight subfamilies. They catalyse the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Mainly, they contain two functional conserved domains, an N-terminal catalytic domain (TBD) adopting a TIM barr... | [
"GO:0017150",
"GO:0050660",
"GO:0008033"
] | [
"tRNA dihydrouridine synthase activity",
"flavin adenine dinucleotide binding",
"tRNA processing"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PIRSF"
] | [
"PIRSF006621"
] | [
"Dus"
] | [
42974
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"1.3.1",
"1.3.1.-",
"PWY-2541",
"PWY-5292",
"PWY-5301",
"PWY-5367",
"PWY-5393",
"PWY-5729",
"PWY-5818",
"PWY-5956",
"PWY-5972",
"PWY-5984",
"PWY-6088",
"PWY-6302",
"PWY-6309",
"PWY-6332",
"PWY-6786",
"PWY-6824",
"PWY-6944",
"PWY-6996",
"PWY-7096",
"PWY-7154",
"PWY-7155",
... | [
"EC:1.3.1",
"EC:1.3.1.-",
"METACYC:PWY-2541",
"METACYC:PWY-5292",
"METACYC:PWY-5301",
"METACYC:PWY-5367",
"METACYC:PWY-5393",
"METACYC:PWY-5729",
"METACYC:PWY-5818",
"METACYC:PWY-5956",
"METACYC:PWY-5972",
"METACYC:PWY-5984",
"METACYC:PWY-6088",
"METACYC:PWY-6302",
"METACYC:PWY-6309",
... | 37 | [
"1vhn",
"3b0p",
"3b0u",
"3b0v",
"3w9z",
"4bf9",
"4bfa",
"4wfs",
"4yco",
"4ycp",
"6ei9",
"6eza",
"6ezb",
"6ezc"
] | 14 | [
"PUB00014304",
"PUB00096089",
"PUB00096095"
] | [
"12003496",
"30149704",
"30605527"
] | [
"A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA.",
"Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.",
"Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase ... | [
2002,
2018,
2019
] | 3 | [] | [
"IPR004652",
"IPR004653",
"IPR032886"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ct8aR17",
"unclassified sequences"
] | [
125,
39818,
2541,
1,
489
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"... | [
8,
1,
1,
3,
3,
2,
4,
3,
2,
1,
3
] | 11 | true | Family | tRNA-dihydrouridine synthase | tRNA-dihydrouridine synthase | DUS_fam | 7 |
IPR001270 | 1,270 | ClpA/B family | ClpA/B | Family | 107,656 | false | false | This family belongs to the AAA+ (ATPase associated with diverse cellular activities) superfamily. Most of these proteins of this family (ClpA, ClpC, ClpD, ClpE, ClpX, HslU) are involved in proteolysis and associate with a separate proteolytic subunit (ClpP, HslV) to form the active protease. ClpB is not involved in pro... | [
"GO:0005524"
] | [
"ATP binding"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR00300"
] | [
"CLPPROTEASEA"
] | [
107656
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00679",
"R-CEL-114608",
"R-CEL-8856825",
"R-DRE-114608",
"R-MMU-114608",
"R-XTR-114608"
] | [
"PROSITEDOC:PDOC00679",
"REACTOME:R-CEL-114608",
"REACTOME:R-CEL-8856825",
"REACTOME:R-DRE-114608",
"REACTOME:R-MMU-114608",
"REACTOME:R-XTR-114608"
] | 6 | [
"1jr3",
"1ksf",
"1njf",
"1njg",
"1qvr",
"1r6b",
"1xxh",
"1xxi",
"3glf",
"3glg",
"3glh",
"3gli",
"3j3r",
"3j3s",
"3j3t",
"3j3u",
"3pxi",
"4ciu",
"4d2q",
"4d2u",
"4d2x",
"4fct",
"4fcv",
"4fcw",
"4fd2",
"4lj4",
"4lj5",
"4lj6",
"4lj7",
"4lj8",
"4lj9",
"4lja"... | 139 | [
"PUB00004102",
"PUB00004707",
"PUB00093976",
"PUB00106739",
"PUB00160474",
"PUB00160475"
] | [
"1896074",
"2185473",
"25305017",
"19131969",
"14570582",
"21469952"
] | [
"Hsp104 is a highly conserved protein with two essential nucleotide-binding sites.",
"Conservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes.",
"Coevolution of the ATPase ClpV, the sheath proteins TssB and TssC, and the accessory protein TagJ/HsiE1 distinguishes ... | [
1991,
1990,
2014,
2009,
2003,
2011
] | 6 | [] | [
"IPR010448",
"IPR013461",
"IPR017729",
"IPR017730",
"IPR044539"
] | 0 | 5 | 0 | [
"Archaea",
"Bacteria",
"Birmingham IncP-alpha plasmid",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
206,
85577,
1,
20536,
73,
1263
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
40,
4,
17,
5,
3,
7,
12,
3,
27,
19,
2,
2,
59
] | 13 | true | Family | ClpA/B family | ClpA/B family | ClpA/B | 1 |
IPR001272 | 1,272 | Phosphoenolpyruvate carboxykinase, ATP-utilising | PEP_carboxykinase_ATP | Family | 19,098 | false | false | Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the first committed (rate-limiting) step in hepatic gluconeogenesis, namely the reversible decarboxylation of oxaloacetate to phosphoenolpyruvate (PEP) and carbon dioxide, using either ATP or GTP as a source of phosphate. The ATP-utilising ( ) and GTP-utilising ( ) en... | [
"GO:0004612",
"GO:0005524",
"GO:0006094"
] | [
"phosphoenolpyruvate carboxykinase (ATP) activity",
"ATP binding",
"gluconeogenesis"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_00453",
"PF01293",
"PIRSF006294",
"PTHR30031",
"TIGR00224",
"cd00484"
] | [
"PEPCK_ATP",
"PEPCK_ATP",
"PEP_crbxkin",
"",
"pckA",
"PEPCK_ATP"
] | [
15984,
18945,
14888,
18226,
15589,
13844
] | 6 | [
"EC",
"GP",
"METACYC",
"METACYC"
] | [
"4.1.1.49",
"GenProp1344",
"PWY-561",
"PWY-7117"
] | [
"EC:4.1.1.49",
"GP:GenProp1344",
"METACYC:PWY-561",
"METACYC:PWY-7117"
] | 4 | [
"1aq2",
"1ayl",
"1ii2",
"1j3b",
"1k3c",
"1k3d",
"1oen",
"1os1",
"1xkv",
"1ygg",
"1ylh",
"1ytm",
"1yvy",
"2olq",
"2olr",
"2pc9",
"2pxz",
"2py7",
"6asi",
"6asm",
"6asn",
"6at2",
"6at3",
"6at4",
"6com",
"6crt",
"6v2l",
"6v2m",
"6v2n"
] | 29 | [
"PUB00003355",
"PUB00035740",
"PUB00035741",
"PUB00035742",
"PUB00035743",
"PUB00035744"
] | [
"8609605",
"16330239",
"15023367",
"15890557",
"17403375",
"16126724"
] | [
"Crystal structure of Escherichia coli phosphoenolpyruvate carboxykinase: a new structural family with the P-loop nucleoside triphosphate hydrolase fold.",
"Nucleotide specificity of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase Kinetics, fluorescence spectroscopy, and molecular simulation studies.",... | [
1996,
2006,
2004,
2005,
2007,
2005
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
239,
13385,
5167,
7,
300
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
16,
1,
1,
15,
1,
36
] | 6 | true | Family | Phosphoenolpyruvate carboxykinase, ATP-utilising | Phosphoenolpyruvate carboxykinase, ATP-utilising | PEP_carboxykinase_ATP | 6 |
IPR001273 | 1,273 | Aromatic amino acid hydroxylase | ArAA_hydroxylase | Family | 18,552 | false | false | Phenylalanine, tyrosine and tryptophan hydroxylases constitute a family of tetrahydrobiopterin-dependent aromatic amino acid hydroxylases, all of which are rate-limiting catalysts for important metabolic pathways [ ]. The proteins are structurally and functionally related, each containing iron, and catalysing ring hydr... | [
"GO:0004497",
"GO:0005506",
"GO:0009072"
] | [
"monooxygenase activity",
"iron ion binding",
"aromatic amino acid metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PANTHER"
] | [
"PTHR11473"
] | [
""
] | [
18552
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.14.16",
"PDOC00316",
"R-BTA-8964208",
"R-CEL-209905",
"R-CEL-8964208",
"R-DDI-209905",
"R-DDI-209931",
"R-DDI-8964208",
"R-DME-209905",
"R-DME-8964208",
"R-HSA-209905",
"R-HSA-209931",
"R-HSA-2160456",
"R-HSA-8964208",
"R-HSA-9031628",
"R-MMU-209905",
"R-MMU-209931",
"R-MMU-8964... | [
"EC:1.14.16",
"PROSITEDOC:PDOC00316",
"REACTOME:R-BTA-8964208",
"REACTOME:R-CEL-209905",
"REACTOME:R-CEL-8964208",
"REACTOME:R-DDI-209905",
"REACTOME:R-DDI-209931",
"REACTOME:R-DDI-8964208",
"REACTOME:R-DME-209905",
"REACTOME:R-DME-8964208",
"REACTOME:R-HSA-209905",
"REACTOME:R-HSA-209931",
... | 21 | [
"1dmw",
"1j8t",
"1j8u",
"1kw0",
"1lrm",
"1ltu",
"1ltv",
"1ltz",
"1mlw",
"1mmk",
"1mmt",
"1pah",
"1phz",
"1tdw",
"1tg2",
"1toh",
"2pah",
"2phm",
"2toh",
"2v27",
"2v28",
"2xsn",
"3e2t",
"3hf6",
"3hf8",
"3hfb",
"3pah",
"3tcy",
"3tk2",
"3tk4",
"4anp",
"4bpt"... | 80 | [
"PUB00003956",
"PUB00004640"
] | [
"9406548",
"3475690"
] | [
"Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria.",
"Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases."
] | [
1997,
1987
] | 2 | [] | [
"IPR005960",
"IPR019773"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"Mimiviridae sp. ChoanoV1",
"metagenomes"
] | [
6343,
12143,
11,
1,
54
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
10,
9,
40,
16,
22
] | 6 | true | Family | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase | ArAA_hydroxylase | 5 |
IPR001275 | 1,275 | DM DNA-binding domain | DM_DNA-bd | Domain | 8,489 | false | false | DMRT genes encode a conserved family of transcription factors that share a unique DNA binding motif, the DM domain [ ]. This domain was first discovered in the doublesex proteins of Drosophila melanogaster [ ]. In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spli... | [
"GO:0043565",
"GO:0006355"
] | [
"sequence-specific DNA binding",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROSITE",
"PROFILE",
"SMART"
] | [
"PF00751",
"PS40000",
"PS50809",
"SM00301"
] | [
"DM",
"DM_1",
"DM_2",
"DM"
] | [
8458,
7888,
8386,
8268
] | 4 | [
"PROSITEDOC",
"REACTOME"
] | [
"PDOC50809",
"R-HSA-9690406"
] | [
"PROSITEDOC:PDOC50809",
"REACTOME:R-HSA-9690406"
] | 2 | [
"1lpv",
"4yj0"
] | 2 | [
"PUB00001940",
"PUB00004274",
"PUB00007136",
"PUB00007137",
"PUB00007138",
"PUB00007139",
"PUB00086561"
] | [
"8978051",
"9490411",
"1907913",
"3046751",
"9927589",
"10898790",
"28774758"
] | [
"Functional and genetic characterization of the oligomerization and DNA binding properties of the Drosophila doublesex proteins.",
"Evidence for evolutionary conservation of sex-determining genes.",
"The doublesex proteins of Drosophila melanogaster bind directly to a sex-specific yolk protein gene enhancer.",
... | [
1996,
1998,
1991,
1988,
1999,
2000,
2017
] | 7 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
8489
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
8,
10,
15,
10,
13
] | 6 | true | Domain | DM DNA-binding domain | DM DNA-binding domain | DM_DNA-bd | 7 |
IPR001277 | 1,277 | CXC chemokine receptor 4/atypical chemokine receptor 2 | CXCR4/ACKR2 | Family | 4,849 | false | false | CXC chemokine receptor 4 (CXCR4), also known as fusin, which is a specific receptor for a CXCL12 (or SDF1). CXCR4 has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types [ , , , , ]. In addition, CXCR4 can also be found on vascular endothelial cells and neuronal/nerve cell... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PRINTS"
] | [
"PR00645"
] | [
"CXCCHMKINER4"
] | [
4849
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"71",
"R-BTA-376176",
"R-BTA-380108",
"R-BTA-418594",
"R-HSA-173107",
"R-HSA-376176",
"R-HSA-380108",
"R-HSA-418594",
"R-HSA-9823730",
"R-HSA-9827857",
"R-HSA-9937080",
"R-MMU-376176",
"R-MMU-380108",
"R-MMU-418594",
"R-RNO-380108",
"R-RNO-418594",
"R-SSC-380108",
"R-SSC-418594"
] | [
"IUPHAR:71",
"REACTOME:R-BTA-376176",
"REACTOME:R-BTA-380108",
"REACTOME:R-BTA-418594",
"REACTOME:R-HSA-173107",
"REACTOME:R-HSA-376176",
"REACTOME:R-HSA-380108",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-9823730",
"REACTOME:R-HSA-9827857",
"REACTOME:R-HSA-9937080",
"REACTOME:R-MMU-376176",
"... | 18 | [
"2k03",
"2k04",
"2k05",
"2n55",
"6gpx",
"8k3z",
"8yu7",
"8zpl",
"8zpm",
"8zpn",
"9d3e",
"9d3g",
"9mdu",
"9me1",
"9mej",
"9men",
"9met",
"9meu",
"9pee"
] | 19 | [
"PUB00064715",
"PUB00064887",
"PUB00064888",
"PUB00064889",
"PUB00064890",
"PUB00064891",
"PUB00064892",
"PUB00064893",
"PUB00064894",
"PUB00064901",
"PUB00064902",
"PUB00064903",
"PUB00077501",
"PUB00077505",
"PUB00077506",
"PUB00077507",
"PUB00077508",
"PUB00077509",
"PUB000775... | [
"12055238",
"9261420",
"10985313",
"11154210",
"11435493",
"9461627",
"9634238",
"11983855",
"18378795",
"11876757",
"12370187",
"10525044",
"19130487",
"12594248",
"15004236",
"26097478",
"23479571",
"15750596",
"23125030",
"23633677",
"25271254"
] | [
"Expression of functional CCR and CXCR chemokine receptors in podocytes.",
"CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus.",
"Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissu... | [
2002,
1997,
2000,
2001,
2001,
1998,
1998,
2002,
2008,
2002,
2002,
1999,
2009,
2003,
2004,
2015,
2013,
2005,
2013,
2013,
2014
] | 21 | [
"IPR000355"
] | [] | 1 | 0 | 1 | [
"Bilateria",
"Tanapox virus"
] | [
4846,
3
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
9,
5,
8
] | 4 | true | Family | CXC chemokine receptor 4/atypical chemokine receptor 2 | CXC chemokine receptor 4/atypical chemokine receptor 2 | CXCR4/ACKR2 | 2 |
IPR001278 | 1,278 | Arginine-tRNA ligase | Arg-tRNA-ligase | Family | 41,187 | false | false | Arginine-tRNA ligase ( ) has been crystallized and preliminary X-ray crystallographic analysis of yeast arginine-tRNA ligase-yeast tRNAArg complexes is available [ ]. Aminoacyl-tRNA synthetases (also known as aminoacyl-tRNA ligases) catalyse the attachment of amino acids to their cognate transfer RNA molecules through ... | [
"GO:0004814",
"GO:0005524",
"GO:0006420"
] | [
"arginine-tRNA ligase activity",
"ATP binding",
"arginyl-tRNA aminoacylation"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"PRINTS",
"PANTHER",
"NCBIFAM"
] | [
"MF_00123",
"PR01038",
"PTHR11956",
"TIGR00456"
] | [
"Arg_tRNA_synth",
"TRNASYNTHARG",
"",
"argS"
] | [
31912,
37947,
41127,
35715
] | 4 | [
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.1.1.19",
"GenProp0258",
"R-BTA-9856649",
"R-DME-9856649",
"R-HSA-2408522",
"R-HSA-379716",
"R-HSA-379726",
"R-HSA-9856649",
"R-MMU-9856649",
"R-RNO-9856649"
] | [
"EC:6.1.1.19",
"GP:GenProp0258",
"REACTOME:R-BTA-9856649",
"REACTOME:R-DME-9856649",
"REACTOME:R-HSA-2408522",
"REACTOME:R-HSA-379716",
"REACTOME:R-HSA-379726",
"REACTOME:R-HSA-9856649",
"REACTOME:R-MMU-9856649",
"REACTOME:R-RNO-9856649"
] | 10 | [
"1bs2",
"1f7u",
"1f7v",
"1iq0",
"2zue",
"2zuf",
"3fnr",
"3gdz",
"4oby",
"4q2t",
"4q2x",
"4q2y",
"4r3z",
"4zaj",
"5b63",
"5jld",
"5yym",
"5yyn",
"6ao8"
] | 19 | [
"PUB00000386",
"PUB00000723",
"PUB00004391",
"PUB00005365",
"PUB00006477",
"PUB00006576",
"PUB00007191",
"PUB00007363",
"PUB00079872",
"PUB00079873"
] | [
"8364025",
"8274143",
"1852601",
"2053131",
"10673435",
"10739930",
"2203971",
"10447505",
"10704480",
"12458790"
] | [
"Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.",
"The aminoacyl-tRNA synthetase family: modules at work.",
"Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.",
"Classes of aminoacyl-tRNA synthetases and the establ... | [
1993,
1993,
1991,
1991,
2000,
2000,
1990,
1999,
2000,
2002
] | 10 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
964,
29667,
9681,
39,
836
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
15,
3,
4,
2,
1,
25,
4,
1,
7,
6,
2,
1,
21
] | 13 | true | Family | Arginine-tRNA ligase | Arginine-tRNA ligase | Arg-tRNA-ligase | 9 |
IPR001279 | 1,279 | Metallo-beta-lactamase | Metallo-B-lactamas | Domain | 384,631 | false | false | Metallo beta lactamases exhibit low sequence identity between enzymes but they are structurally similar. They have a characteristic α-β/β-α sandwich fold in which the active site is at the interface between domains. Apart from the beta-lactamases and metallo-beta-lactamases, a number of other proteins contain this doma... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PFAM",
"SMART"
] | [
"PF00753",
"PF12706",
"PF16661",
"SM00849"
] | [
"Lactamase_B",
"Lactamase_B_2",
"Lactamase_B_6",
"Lactamase_B"
] | [
251823,
92644,
13910,
312433
] | 4 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-159231",
"R-BTA-1614517",
"R-BTA-70268",
"R-BTA-72187",
"R-BTA-72203",
"R-BTA-73856",
"R-BTA-77595",
"R-CEL-72187",
"R-CEL-72203",
"R-CEL-73856",
"R-CEL-77595",
"R-DDI-6807505",
"R-DDI-70268",
"R-DDI-77595",
"R-DME-159231",
"R-DME-6807505",
"R-DME-72187",
"R-DME-72203",
"R... | [
"REACTOME:R-BTA-159231",
"REACTOME:R-BTA-1614517",
"REACTOME:R-BTA-70268",
"REACTOME:R-BTA-72187",
"REACTOME:R-BTA-72203",
"REACTOME:R-BTA-73856",
"REACTOME:R-BTA-77595",
"REACTOME:R-CEL-72187",
"REACTOME:R-CEL-72203",
"REACTOME:R-CEL-73856",
"REACTOME:R-CEL-77595",
"REACTOME:R-DDI-6807505",
... | 49 | [
"1a7t",
"1a8t",
"1bc2",
"1bmc",
"1bvt",
"1dd6",
"1ddk",
"1dxk",
"1e5d",
"1hlk",
"1jje",
"1jjt",
"1ko2",
"1ko3",
"1kr3",
"1l9y",
"1m2x",
"1mqo",
"1p9e",
"1qh3",
"1qh5",
"1sml",
"1vgn",
"1vme",
"1wra",
"1wuo",
"1wup",
"1ww1",
"1x8g",
"1x8h",
"1x8i",
"1xm8"... | 1,215 | [
"PUB00001273",
"PUB00095151"
] | [
"7588620",
"23163348"
] | [
"The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold.",
"Metallo-?-lactamase structure and function."
] | [
1995,
2013
] | 2 | [] | [
"IPR030829",
"IPR035639",
"IPR035680",
"IPR035681",
"IPR035682",
"IPR037482",
"IPR041712",
"IPR041897",
"IPR044094",
"IPR044097",
"IPR044528",
"IPR045761",
"IPR047917",
"IPR047921",
"IPR049721"
] | 0 | 15 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
14022,
303137,
61927,
220,
5325
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
87,
17,
19,
14,
7,
61,
36,
14,
53,
49,
6,
6,
111
] | 13 | true | Domain | Metallo-beta-lactamase | Metallo-beta-lactamase | Metallo-B-lactamas | 7 |
IPR001280 | 1,280 | Photosystem I PsaA/PsaB | PSI_PsaA/B | Family | 36,140 | false | false | Photosystem I (PSI) [ ] is an integral membrane protein complex that uses light energy to mediate electron transfer from plastocyanin to ferredoxin. PSI is found in the chloroplast of plants and cyanobacteria. The electron transfer components of the reaction centre of PSI are a primary electron donor P-700 (chlorophyll... | [
"GO:0015979",
"GO:0009579",
"GO:0016020"
] | [
"photosynthesis",
"thylakoid",
"membrane"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"PFAM",
"PIRSF",
"PRINTS"
] | [
"PF00223",
"PIRSF002905",
"PR00257"
] | [
"PsaA_PsaB",
"PSI_A",
"PHOTSYSPSAAB"
] | [
36138,
28355,
34915
] | 3 | [
"EC",
"GP",
"METACYC",
"METACYC",
"PROSITEDOC"
] | [
"1.97.1.12",
"GenProp1353",
"PWY-101",
"PWY-8270",
"PDOC00347"
] | [
"EC:1.97.1.12",
"GP:GenProp1353",
"METACYC:PWY-101",
"METACYC:PWY-8270",
"PROSITEDOC:PDOC00347"
] | 5 | [
"1jb0",
"2o01",
"2wsc",
"2wse",
"2wsf",
"3lw5",
"3pcq",
"4fe1",
"4kt0",
"4l6v",
"4rku",
"4xk8",
"4y28",
"5l8r",
"5oy0",
"5v8k",
"5zf0",
"5zgb",
"5zgh",
"5zji",
"6fos",
"6hqb",
"6igz",
"6ijj",
"6ijo",
"6jeo",
"6jo5",
"6jo6",
"6k33",
"6k61",
"6kif",
"6kig"... | 155 | [
"PUB00000583",
"PUB00001586"
] | [
"3333014",
"2186925"
] | [
"Structure, function and organization of the Photosystem I reaction center complex.",
"Photosystem I reaction-centre proteins contain leucine zipper motifs. A proposed role in dimer formation."
] | [
1987,
1990
] | 2 | [] | [
"IPR006243",
"IPR006244"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Viruses",
"marine metagenome"
] | [
1520,
34606,
12,
2
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
18,
9
] | 3 | true | Family | Photosystem I PsaA/PsaB | Photosystem I PsaA/PsaB | PSI_PsaA/B | 9 |
IPR001282 | 1,282 | Glucose-6-phosphate dehydrogenase | G6P_DH | Family | 38,233 | false | false | Glucose-6-phosphate dehydrogenase ( ) (G6PDH) is a ubiquitous protein, present in bacteria and all eukaryotic cell types [ ]. The enzyme catalyses the the first step in the pentose pathway, i.e. the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH. The ubiquitous ... | [
"GO:0016614",
"GO:0050661",
"GO:0006006"
] | [
"oxidoreductase activity, acting on CH-OH group of donors",
"NADP binding",
"glucose metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"PIRSF",
"PRINTS",
"PANTHER",
"NCBIFAM"
] | [
"MF_00966",
"PIRSF000110",
"PR00079",
"PTHR23429",
"TIGR00871"
] | [
"G6PD",
"G6PD",
"G6PDHDRGNASE",
"",
"zwf"
] | [
32237,
30772,
36238,
38194,
31271
] | 5 | [
"EC",
"EC",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"R... | [
"1.1.1",
"1.1.1.49",
"GenProp0120",
"GenProp1502",
"GenProp1520",
"GenProp1691",
"PWY-7268",
"PWY-8004",
"PDOC00067",
"R-CEL-5628897",
"R-CEL-71336",
"R-DDI-5628897",
"R-DDI-71336",
"R-DME-5628897",
"R-DME-71336",
"R-HSA-5628897",
"R-HSA-71336",
"R-HSA-9818028",
"R-MMU-5628897",
... | [
"EC:1.1.1",
"EC:1.1.1.49",
"GP:GenProp0120",
"GP:GenProp1502",
"GP:GenProp1520",
"GP:GenProp1691",
"METACYC:PWY-7268",
"METACYC:PWY-8004",
"PROSITEDOC:PDOC00067",
"REACTOME:R-CEL-5628897",
"REACTOME:R-CEL-71336",
"REACTOME:R-DDI-5628897",
"REACTOME:R-DDI-71336",
"REACTOME:R-DME-5628897",
... | 28 | [
"1dpg",
"1e77",
"1e7m",
"1e7y",
"1h93",
"1h94",
"1h9a",
"1h9b",
"1qki",
"2bh9",
"2bhl",
"2dpg",
"4lgv",
"5aq1",
"5ukw",
"6d23",
"6d24",
"6e07",
"6e08",
"6jyu",
"6va0",
"6va7",
"6va8",
"6va9",
"6vaq",
"7e6h",
"7e6i",
"7seh",
"7sei",
"7snf",
"7sng",
"7snh"... | 58 | [
"PUB00001763",
"PUB00097191",
"PUB00097192"
] | [
"2838391",
"26479991",
"24769394"
] | [
"Nucleotide sequence of the Drosophila glucose-6-phosphate dehydrogenase gene and comparison with the homologous human gene.",
"Severe G6PD Deficiency Due to a New Missense Mutation in an Infant of Northern European Descent.",
"Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cel... | [
1988,
2015,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
5,
26635,
11243,
24,
326
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
33,
1,
10,
3,
1,
35,
10,
1,
18,
5,
1,
3,
37
] | 13 | true | Family | Glucose-6-phosphate dehydrogenase | Glucose-6-phosphate dehydrogenase | G6P_DH | 8 |
IPR001285 | 1,285 | Synaptophysin/synaptoporin | Synaptophysin/porin | Family | 5,462 | false | false | Synaptophysin and synaptoporin are related glycoproteins: they are the major integral membrane proteins of a certain class of small neurosecretory vesicles, although they may also be found in vesicles of various non-endocrine cells [ , ]. The polypeptide chain spans the membrane four times and possibly acts as an ion o... | [
"GO:0008021",
"GO:0016020"
] | [
"synaptic vesicle",
"membrane"
] | [
"cellular_component",
"cellular_component"
] | 2 | [
"PRINTS",
"PROSITE",
"PANTHER"
] | [
"PR00220",
"PS00604",
"PTHR10306"
] | [
"SYNAPTOPHYSN",
"SYNAPTOP",
""
] | [
5041,
633,
5427
] | 3 | [
"PROSITEDOC",
"REACTOME"
] | [
"PDOC00525",
"R-HSA-9662360"
] | [
"PROSITEDOC:PDOC00525",
"REACTOME:R-HSA-9662360"
] | 2 | [
"9b8o",
"9bra",
"9brb",
"9brc",
"9brd",
"9brq",
"9brt",
"9brz"
] | 8 | [
"PUB00001155",
"PUB00002501"
] | [
"3123215",
"2492017"
] | [
"Synaptophysin: molecular organization and mRNA expression as determined from cloned cDNA.",
"Transmembrane topography and evolutionary conservation of synaptophysin."
] | [
1987,
1989
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"bird metagenome"
] | [
5460,
2
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
13,
24,
12,
23
] | 5 | true | Family | Synaptophysin/synaptoporin | Synaptophysin/synaptoporin | Synaptophysin/porin | 9 |
IPR001286 | 1,286 | Glycoside hydrolase, family 59 | Glyco_hydro_59 | Family | 2,859 | false | false | Glycoside hydrolase family 59 comprises enzymes with only one known activity; galactocerebrosidase ( ). Globoid cell leukodystrophy (Krabbe disease) is a severe, autosomal recessive disorder that results from deficiency of galactocerebrosidase (GALC) activity [ , , ]. GALC is responsible for the lysosomal catabolism of... | [
"GO:0004336",
"GO:0006683"
] | [
"galactosylceramidase activity",
"galactosylceramide catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS",
"PANTHER"
] | [
"PR00850",
"PTHR15172"
] | [
"GLHYDRLASE59",
""
] | [
2183,
2858
] | 2 | [
"CAZY",
"EC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GH59",
"3.2.1.46",
"R-CEL-9840310",
"R-HSA-9840310",
"R-MMU-9840310"
] | [
"CAZY:GH59",
"EC:3.2.1.46",
"REACTOME:R-CEL-9840310",
"REACTOME:R-HSA-9840310",
"REACTOME:R-MMU-9840310"
] | 5 | [
"3zr5",
"3zr6",
"4ccc",
"4ccd",
"4cce",
"4ufh",
"4ufi",
"4ufj",
"4ufk",
"4ufl",
"4ufm",
"5nxb",
"6y6s",
"6y6t"
] | 14 | [
"PUB00000576",
"PUB00001963",
"PUB00001972",
"PUB00004870",
"PUB00005266"
] | [
"9434153",
"7601472",
"8661004",
"7624375",
"8535779"
] | [
"Human galactocerebrosidase gene: promoter analysis of the 5'-flanking region and structural organization.",
"Structure and organization of the human galactocerebrosidase (GALC) gene.",
"Cloning of the canine GALC cDNA and identification of the mutation causing globoid cell leukodystrophy in West Highland White... | [
1998,
1995,
1996,
1995,
1995
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
860,
1996,
3
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
8,
3,
5
] | 5 | true | Family | Glycoside hydrolase, family 59 | Glycoside hydrolase, family 59 | Glyco_hydro_59 | 5 |
IPR001287 | 1,287 | Nitrite reductase, copper-type | NO2-reductase_Cu | Family | 5,485 | false | false | These enzymes are involved in nitrate assimilation in the denitrification pathway. The 3D structure of the copper-containing nitrite reductase (NIR) from Achromobacter cycloclastes has been determined to 2.3A resolution [ ]. The enzyme is a trimer, each monomer of which contains two Greek key β-barrel domains (similar ... | [
"GO:0005507",
"GO:0050421"
] | [
"copper ion binding",
"nitrite reductase (NO-forming) activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PRINTS",
"NCBIFAM"
] | [
"PR00695",
"TIGR02376"
] | [
"CUNO2RDTASE",
"Cu_nitrite_red"
] | [
5419,
2370
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.7.2.1",
"PWY-6523",
"PWY-6748",
"PWY-7084"
] | [
"EC:1.7.2.1",
"METACYC:PWY-6523",
"METACYC:PWY-6748",
"METACYC:PWY-7084"
] | 4 | [
"1aq8",
"1as6",
"1as7",
"1as8",
"1bq5",
"1et5",
"1et7",
"1et8",
"1gs6",
"1gs7",
"1gs8",
"1hau",
"1haw",
"1j9q",
"1j9r",
"1j9s",
"1j9t",
"1kbv",
"1kbw",
"1kcb",
"1l9o",
"1l9p",
"1l9q",
"1l9r",
"1l9s",
"1l9t",
"1mzy",
"1mzz",
"1n70",
"1ndr",
"1nds",
"1ndt"... | 283 | [
"PUB00005146"
] | [
"1862344"
] | [
"The 2.3 angstrom X-ray structure of nitrite reductase from Achromobacter cycloclastes."
] | [
1991
] | 1 | [
"IPR045087"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
992,
4069,
340,
84
] | 4 | [] | [] | 0 | true | Family | Nitrite reductase, copper-type | Nitrite reductase, copper-type | NO2-reductase_Cu | 1 |
IPR001288 | 1,288 | Translation initiation factor 3 | Translation_initiation_fac_3 | Family | 30,207 | false | false | Initiation factor 3 (IF-3) (gene infC) is one of the three factors required for the initiation of protein biosynthesis in bacteria. IF-3 is thought to function as a fidelity factor during the assembly of the ternary initiation complex which consist of the 30S ribosomal subunit, the initiator tRNA and the messenger RNA.... | [
"GO:0003743",
"GO:0006413"
] | [
"translation initiation factor activity",
"translational initiation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PANTHER",
"NCBIFAM"
] | [
"MF_00080",
"PTHR10938",
"TIGR00168"
] | [
"IF_3",
"",
"infC"
] | [
21629,
30125,
28044
] | 3 | [
"GP",
"PROSITEDOC",
"REACTOME"
] | [
"GenProp0740",
"PDOC00723",
"R-HSA-5368286"
] | [
"GP:GenProp0740",
"PROSITEDOC:PDOC00723",
"REACTOME:R-HSA-5368286"
] | 3 | [
"1i96",
"1tif",
"1tig",
"2crq",
"2ife",
"2m71",
"5lmn",
"5lmo",
"5lmp",
"5lmq",
"5lmr",
"5lms",
"5lmt",
"5lmu",
"5lmv",
"5me0",
"5me1",
"6neq",
"6nf8",
"6o6d",
"6rw4",
"6rw5",
"6vrj",
"7p2e",
"7po0",
"7po1",
"8jsg",
"8jsh",
"8qrm",
"9fco",
"9fda",
"9fib"... | 37 | [
"PUB00001732",
"PUB00002896"
] | [
"8405963",
"8144528"
] | [
"Molecular cloning and sequencing of infC, the gene encoding translation initiation factor IF3, from four enterobacterial species.",
"Isolation and characterization of cDNA clones for chloroplast translational initiation factor-3 from Euglena gracilis."
] | [
1993,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nitrososphaerota",
"Viruses",
"unclassified sequences"
] | [
24960,
4679,
2,
24,
542
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pomb... | [
16,
9,
4,
1,
1,
2,
1,
5,
3,
1,
8
] | 11 | true | Family | Translation initiation factor 3 | Translation initiation factor 3 | Translation_initiation_fac_3 | 1 |
IPR001289 | 1,289 | Nuclear transcription factor Y subunit A | NFYA | Family | 11,254 | false | false | Diverse DNA binding proteins are known to bind the CCAAT box, a common cis- acting element found in the promoter and enhancer regions of a large number of genes in eukaryotes. Amongst these proteins is one known as the CCAAT-binding factor (CBF) or nuclear transcription factor Y (NF-Y) [ ]. CBF is a heteromeric transcr... | [
"GO:0003700",
"GO:0006355"
] | [
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PRINTS",
"PROFILE",
"PANTHER",
"SMART"
] | [
"PF02045",
"PR00616",
"PS51152",
"PTHR12632",
"SM00521"
] | [
"CBFB_NFYA",
"CCAATSUBUNTB",
"NFYA_HAP2_2",
"",
"CBF"
] | [
10785,
9699,
11217,
10543,
10627
] | 5 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00578",
"R-HSA-1989781",
"R-HSA-2426168",
"R-HSA-380994",
"R-HSA-381183",
"R-HSA-9614657"
] | [
"PROSITEDOC:PDOC00578",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-2426168",
"REACTOME:R-HSA-380994",
"REACTOME:R-HSA-381183",
"REACTOME:R-HSA-9614657"
] | 6 | [
"3jbn",
"3jbo",
"3jbp",
"4awl",
"4g91",
"4g92",
"6qmp",
"6qmq",
"6qms",
"6r2v",
"6y35",
"6y36",
"6y37",
"6y39",
"7aw7",
"7aw9",
"8qu2",
"8qu3",
"8qu4"
] | 19 | [
"PUB00003675",
"PUB00004401"
] | [
"1899284",
"1549471"
] | [
"The Schizosaccharomyces pombe homolog of Saccharomyces cerevisiae HAP2 reveals selective and stringent conservation of the small essential core protein domain.",
"Evolutionary variation of the CCAAT-binding transcription factor NF-Y."
] | [
1991,
1992
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"marine metagenome"
] | [
50,
11097,
106,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
50,
2,
30,
3,
3,
9,
1,
40,
7,
1,
1,
118
] | 12 | true | Family | Nuclear transcription factor Y subunit A | Nuclear transcription factor Y subunit A | NFYA | 8 |
IPR001292 | 1,292 | Estrogen receptor | Estr_rcpt | Family | 1,367 | false | false | Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and r... | [
"GO:0003677",
"GO:0005496",
"GO:0030284",
"GO:0006355",
"GO:0043401",
"GO:0005634"
] | [
"DNA binding",
"steroid binding",
"nuclear estrogen receptor activity",
"regulation of DNA-templated transcription",
"steroid hormone receptor signaling pathway",
"nucleus"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 6 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF500101",
"PR00543"
] | [
"ER-a",
"OESTROGENR"
] | [
1034,
917
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1251985",
"R-BTA-1257604",
"R-BTA-383280",
"R-BTA-4090294",
"R-BTA-5689896",
"R-BTA-6811558",
"R-BTA-8866910",
"R-BTA-8931987",
"R-BTA-8939211",
"R-BTA-9009391",
"R-BTA-9018519",
"R-BTA-9841251",
"R-DRE-1251985",
"R-DRE-1257604",
"R-DRE-5689896",
"R-DRE-6811558",
"R-DRE-893921... | [
"REACTOME:R-BTA-1251985",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-383280",
"REACTOME:R-BTA-4090294",
"REACTOME:R-BTA-5689896",
"REACTOME:R-BTA-6811558",
"REACTOME:R-BTA-8866910",
"REACTOME:R-BTA-8931987",
"REACTOME:R-BTA-8939211",
"REACTOME:R-BTA-9009391",
"REACTOME:R-BTA-9018519",
"REACTOME... | 71 | [] | 0 | [
"PUB00004464",
"PUB00006168",
"PUB00015853",
"PUB00016725",
"PUB00016726",
"PUB00016727"
] | [
"7899080",
"8165128",
"14747695",
"15728727",
"14612550",
"15831449"
] | [
"Vitamin D receptor contains multiple dimerization interfaces that are functionally different.",
"Human androgen receptor expressed in HeLa cells activates transcription in vitro.",
"Nuclear receptors: the evolution of diversity.",
"Delineation of a unique protein-protein interaction site on the surface of th... | [
1995,
1994,
2004,
2005,
2003,
2005
] | 6 | [
"IPR024178"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1367
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
25,
10,
17
] | 4 | true | Family | Estrogen receptor | Estrogen receptor | Estr_rcpt | 4 |
IPR001293 | 1,293 | Zinc finger, TRAF-type | Znf_TRAF | Domain | 21,547 | false | false | This entry represents TRAF-type zinc finger domains. Some of the proteins that have this domain are mammalian signal transducers associated with the cytoplasmic domain of the 75kDa tumour necrosis factor receptor [ ]. A heterocomplex, homodimer or heterodimer of TRAF1 and TRAF2, binds to the N-terminal of the inhibitor... | [
"GO:0008270"
] | [
"zinc ion binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PFAM",
"PROFILE"
] | [
"PF02176",
"PF15965",
"PS50145"
] | [
"zf-TRAF",
"zf-TRAF_2",
"ZF_TRAF"
] | [
13090,
2843,
20963
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50145",
"R-BTA-1257604",
"R-BTA-166058",
"R-BTA-193692",
"R-BTA-202424",
"R-BTA-205043",
"R-BTA-209543",
"R-BTA-209560",
"R-BTA-2871837",
"R-BTA-450302",
"R-BTA-450321",
"R-BTA-5607764",
"R-BTA-5689880",
"R-BTA-5689896",
"R-BTA-6811558",
"R-BTA-9020702",
"R-BTA-937039",
"R-BTA... | [
"PROSITEDOC:PDOC50145",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-166058",
"REACTOME:R-BTA-193692",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-205043",
"REACTOME:R-BTA-209543",
"REACTOME:R-BTA-209560",
"REACTOME:R-BTA-2871837",
"REACTOME:R-BTA-450302",
"REACTOME:R-BTA-450321",
"REACTOME:R-BTA-56... | 190 | [
"2eod",
"2yre",
"2yuc",
"3hcs",
"5vo0",
"7l3l",
"8hz2"
] | 7 | [
"PUB00014077",
"PUB00015838",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812"
] | [
"12665246",
"11607847",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890"
] | [
"Zinc fingers--folds for many occasions.",
"Tumor necrosis factor receptor-associated factors (TRAFs).",
"Sticky fingers: zinc-fingers as protein-recognition motifs.",
"Multiple modes of RNA recognition by zinc finger proteins.",
"Zinc finger proteins: getting a grip on RNA.",
"Zinc finger peptides for th... | [
2002,
2001,
2007,
2005,
2005,
1999,
2001
] | 7 | [] | [] | 0 | 0 | null | [
"Endozoicomonadaceae",
"Eukaryota",
"Viruses",
"organismal metagenomes"
] | [
13,
21516,
16,
2
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
2,
40,
4,
34,
27,
1,
16,
40,
17
] | 10 | true | Domain | Zinc finger, TRAF-type | Zinc finger, TRAF-type | Znf_TRAF | 3 |
IPR001294 | 1,294 | Phytochrome | Phytochrome | Family | 18,438 | false | false | Phytochromes are a class of photoreceptor found in plants, bacteria and fungi, which are used to detect light. In plants, phytochromes mediate physiological and developmental responses to changes in red and far-red light conditions [ ]. The protein undergoes reversible photochemical conversion between a biologically-in... | [
"GO:0006355",
"GO:0009584"
] | [
"regulation of DNA-templated transcription",
"detection of visible light"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR01033"
] | [
"PHYTOCHROME"
] | [
18438
] | 1 | [] | [] | [] | 0 | [
"1ztu",
"2k2n",
"2kli",
"2koi",
"2lb5",
"2lb9",
"2o9b",
"2o9c",
"2ool",
"2vea",
"3c2w",
"3g6o",
"3ibr",
"3nhq",
"3nop",
"3not",
"3nou",
"3s7n",
"3s7o",
"3s7p",
"3s7q",
"3zq5",
"4bwi",
"4cqh",
"4e04",
"4gw9",
"4ijg",
"4o01",
"4o0p",
"4o8g",
"4our",
"4q0h"... | 166 | [
"PUB00000104",
"PUB00001889",
"PUB00004519"
] | [
"1812812",
"2606345",
"8453299"
] | [
"Phytochrome: a light-activated molecular switch that regulates plant gene expression.",
"Novel phytochrome sequences in Arabidopsis thaliana: structure, evolution, and differential expression of a plant regulatory photoreceptor family.",
"Mutations in the gene for the red/far-red light receptor phytochrome B a... | [
1991,
1989,
1993
] | 3 | [] | [
"IPR009219",
"IPR012129"
] | 0 | 2 | 0 | [
"Bacteria",
"Ectocarpus siliculosus virus 1 (isolate New Zealand/Kaikoura/1988)",
"Eukaryota",
"unclassified sequences"
] | [
5053,
1,
13374,
10
] | 4 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
78,
2,
36,
50
] | 4 | true | Family | Phytochrome | Phytochrome | Phytochrome | 1 |
IPR001295 | 1,295 | Dihydroorotate dehydrogenase, conserved site | Dihydroorotate_DH_CS | Conserved_site | 34,105 | false | false | Dihydroorotate dehydrogenase ( ) (DHOdehase) catalyses the fourth step in the de novo biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate. DHOdehase is a ubiquitous FAD flavoprotein. In bacteria (gene pyrD), DHOdease is located on the inner side of the cytosolic membrane. In some yeasts, such as i... | [
"GO:0016627",
"GO:0006207"
] | [
"oxidoreductase activity, acting on the CH-CH group of donors",
"'de novo' pyrimidine nucleobase biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE",
"PROSITE"
] | [
"PS00911",
"PS00912"
] | [
"DHODEHASE_1",
"DHODEHASE_2"
] | [
25311,
29188
] | 2 | [
"EC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.3.5.2",
"PWY-5686",
"PDOC00708",
"R-DME-500753",
"R-HSA-500753",
"R-MMU-500753",
"R-PFA-500753",
"R-RNO-500753",
"R-SPO-500753"
] | [
"EC:1.3.5.2",
"METACYC:PWY-5686",
"PROSITEDOC:PDOC00708",
"REACTOME:R-DME-500753",
"REACTOME:R-HSA-500753",
"REACTOME:R-MMU-500753",
"REACTOME:R-PFA-500753",
"REACTOME:R-RNO-500753",
"REACTOME:R-SPO-500753"
] | 9 | [
"1d3g",
"1d3h",
"1dor",
"1ep1",
"1ep2",
"1ep3",
"1f76",
"1jqv",
"1jqx",
"1jrb",
"1jrc",
"1jub",
"1jue",
"1ovd",
"1tv5",
"1uum",
"1uuo",
"1ypf",
"2a1y",
"2b0m",
"2bsl",
"2bx7",
"2bxv",
"2dor",
"2fpt",
"2fpv",
"2fpy",
"2fqi",
"2prh",
"2prl",
"2prm",
"2wv8"... | 173 | [
"PUB00004801"
] | [
"1409592"
] | [
"Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts."
] | [
1992
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1013,
26998,
5431,
5,
658
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (s... | [
5,
1,
5,
5,
1,
4,
7,
1,
8,
1,
1,
3
] | 12 | true | Conserved_site | Dihydroorotate dehydrogenase, conserved site | Dihydroorotate dehydrogenase, conserved site | Dihydroorotate_DH_CS | 7 |
IPR001296 | 1,296 | Glycosyl transferase, family 1 | Glyco_trans_1 | Domain | 314,316 | false | false | Proteins containing this domain transfer UDP, ADP, GDP or CMP linked sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. The bacterial enzymes are involved in various biosynthetic processes that include exopolysaccharide biosynthesis, lipopolysaccharide core biosynthesis... | [
"GO:0016757"
] | [
"glycosyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00534"
] | [
"Glycos_transf_1"
] | [
314316
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.1",
"GenProp1302",
"GenProp1325",
"GenProp1398",
"GenProp1546",
"GenProp1647",
"GenProp1651",
"GenProp1684",
"R-DDI-446193",
"R-HSA-162710",
"R-HSA-446193",
"R-HSA-4549349",
"R-HSA-4549380",
"R-HSA-4551295",
"R-MMU-162710",
"R-MMU-446193",
"R-MTU-879299",
"R-SCE-446193",
"R-... | [
"EC:2.4.1",
"GP:GenProp1302",
"GP:GenProp1325",
"GP:GenProp1398",
"GP:GenProp1546",
"GP:GenProp1647",
"GP:GenProp1651",
"GP:GenProp1684",
"REACTOME:R-DDI-446193",
"REACTOME:R-HSA-162710",
"REACTOME:R-HSA-446193",
"REACTOME:R-HSA-4549349",
"REACTOME:R-HSA-4549380",
"REACTOME:R-HSA-4551295",... | 19 | [
"1rzu",
"1rzv",
"2f9f",
"2iuy",
"2iv3",
"2iv7",
"2iw1",
"2jjm",
"2qzs",
"2r4t",
"2r4u",
"2r60",
"2r66",
"2r68",
"2x6q",
"2x6r",
"2xa1",
"2xa2",
"2xa9",
"2xmp",
"3c48",
"3c4q",
"3c4v",
"3cop",
"3cx4",
"3d1j",
"3guh",
"3mbo",
"3oka",
"3okc",
"3okp",
"3qhp"... | 119 | [
"PUB00009409",
"PUB00096717"
] | [
"9334165",
"12037021"
] | [
"A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities.",
"Mutation analysis of the PIG-A gene in Korean patients with paroxysmal nocturnal haemoglobinuria."
] | [
1997,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
8270,
259346,
40979,
165,
5556
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
135,
4,
14,
6,
7,
75,
10,
7,
114,
20,
4,
7,
258
] | 13 | true | Domain | Glycosyl transferase, family 1 | Glycosyl transferase, family 1 | Glyco_trans_1 | 6 |
IPR001297 | 1,297 | Phycobilisome linker domain | PBS_linker_dom | Domain | 2,780 | false | false | Phycobilisomes (PBSs) are the major light-harvesting systems in cyanobacteria and red algae. PBS is a supercomplex that is composed of a core complex and multiple peripheral rod complexes. Typically, the core consists of two or five cylinders lying on the membrane with, in most cases, multiple rods radiating from the c... | [
"GO:0015979",
"GO:0030089"
] | [
"photosynthesis",
"phycobilisome"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PROFILE"
] | [
"PF00427",
"PS51445"
] | [
"PBS_linker_poly",
"PBS_LINKER"
] | [
2776,
2772
] | 2 | [] | [] | [] | 0 | [
"2ky4",
"2l06",
"2l3w",
"2l8v",
"3nph",
"3ohw",
"3osj",
"3pru",
"5y6p",
"6kgx",
"7ext",
"7eyd",
"7ezx",
"7liz",
"7lj0",
"7sc7",
"7sc8",
"7sc9",
"7sca",
"7scb",
"7scc",
"7tz8",
"7vea",
"7veb",
"7y4l",
"7y5e",
"7y7a",
"8hfq",
"8imi",
"8imj",
"8imk",
"8iml"... | 48 | [
"PUB00052617",
"PUB00052618",
"PUB00052619",
"PUB00052620",
"PUB00052621"
] | [
"2107546",
"1743523",
"15922288",
"17310305",
"17468217"
] | [
"Molecular characterization of the terminal energy acceptor of cyanobacterial phycobilisomes.",
"A small multigene family encodes the rod-core linker polypeptides of Anabaena sp. PCC7120 phycobilisomes.",
"Characterization, structure and function of linker polypeptides in phycobilisomes of cyanobacteria and red... | [
1990,
1991,
2005,
2007,
2007
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2231,
549
] | 2 | [] | [] | 0 | true | Domain | Phycobilisome linker domain | Phycobilisome linker domain | PBS_linker_dom | 5 |
IPR001298 | 1,298 | Filamin/ABP280 repeat | Filamin/ABP280_rpt | Repeat | 21,161 | false | false | The many different actin cross-linking proteins share a common architecture, consisting of a globular actin-binding domain and an extended rod. Whereas their actin-binding domains consist of two calponin homology domains (see ), their rods fall into three families. The rod domain of the family including the Dictyosteli... | [
"GO:0005515"
] | [
"protein binding"
] | [
"molecular_function"
] | 1 | [
"SMART"
] | [
"SM00557"
] | [
"IG_FLMN"
] | [
21161
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-6798695",
"R-DDI-114608",
"R-DDI-1169408",
"R-DDI-446353",
"R-DDI-5627123",
"R-DME-114608",
"R-DME-1169408",
"R-DME-446353",
"R-DME-5627123",
"R-DRE-983168",
"R-HSA-114608",
"R-HSA-1169408",
"R-HSA-430116",
"R-HSA-446353",
"R-HSA-5627123",
"R-HSA-877300",
"R-HSA-8983711",
"R... | [
"REACTOME:R-CEL-6798695",
"REACTOME:R-DDI-114608",
"REACTOME:R-DDI-1169408",
"REACTOME:R-DDI-446353",
"REACTOME:R-DDI-5627123",
"REACTOME:R-DME-114608",
"REACTOME:R-DME-1169408",
"REACTOME:R-DME-446353",
"REACTOME:R-DME-5627123",
"REACTOME:R-DRE-983168",
"REACTOME:R-HSA-114608",
"REACTOME:R-HS... | 26 | [
"1ksr",
"1qfh",
"1v05",
"1wlh",
"2aav",
"2bp3",
"2brq",
"2d7m",
"2d7n",
"2d7o",
"2d7p",
"2d7q",
"2di7",
"2di8",
"2di9",
"2dia",
"2dib",
"2dic",
"2dj4",
"2dlg",
"2dmb",
"2dmc",
"2ds4",
"2e9i",
"2e9j",
"2ee6",
"2ee9",
"2eea",
"2eeb",
"2eec",
"2eed",
"2j3s"... | 72 | [
"PUB00003939",
"PUB00010566",
"PUB00010567",
"PUB00010568"
] | [
"9164464",
"9417983",
"10467095",
"2668299"
] | [
"The repeating segments of the F-actin cross-linking gelation factor (ABP-120) have an immunoglobulin-like fold.",
"Crystallization and preliminary X-Ray diffraction characterization of a dimerizing fragment of the rod domain of the Dictyostelium gelation factor (ABP-120).",
"Structural basis for dimerization o... | [
1997,
1997,
1999,
1989
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"bird metagenome"
] | [
16,
21139,
6
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
20,
46,
47,
28,
74,
30,
3,
36,
16
] | 9 | true | Repeat | Filamin/ABP280 repeat | Filamin/ABP280 repeat | Filamin/ABP280_rpt | 9 |
IPR001299 | 1,299 | Ependymin | Ependymin | Family | 2,958 | false | false | Ependymins are secretory proteins found predominantly in the cerebrospinal fluid of teleost fish [ , ]. A bound form of the glycoproteins is associated with the extracellular matrix, probably with collagen fibrils, that may be the functional form of ependymins [ ]. The proteins bind calcium via N-linked sialic acid res... | [
"GO:0005509",
"GO:0007160",
"GO:0005576"
] | [
"calcium ion binding",
"cell-matrix adhesion",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PRINTS",
"PANTHER",
"SMART"
] | [
"PF00811",
"PR00317",
"PTHR10697",
"SM00026"
] | [
"Ependymin",
"EPENDYMIN",
"",
"EPEND"
] | [
2737,
1685,
2876,
1491
] | 4 | [
"PROSITEDOC"
] | [
"PDOC00699"
] | [
"PROSITEDOC:PDOC00699"
] | 1 | [
"6e7o",
"6e8n",
"6jl9",
"6jla",
"6jld",
"6l9x",
"6lxx",
"8i34"
] | 8 | [
"PUB00000027",
"PUB00002045",
"PUB00003426"
] | [
"1831964",
"8005346",
"8350351"
] | [
"Ependymin, a brain extracellular glycoprotein, and CNS plasticity.",
"Ependymins and their potential role in neuroplasticity and regeneration: calcium-binding meningeal glycoproteins of the cerebrospinal fluid and extracellular matrix.",
"Molecular analysis of ependymins from the cerebrospinal fluid of the ord... | [
1991,
1994,
1993
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2958
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
4,
2,
3
] | 4 | true | Family | Ependymin | Ependymin | Ependymin | 8 |
IPR001300 | 1,300 | Peptidase C2, calpain, catalytic domain | Peptidase_C2_calpain_cat | Domain | 38,487 | false | false | This group of cysteine peptidases belong to the MEROPS peptidase family C2 (calpain family, clan CA). A type example is calpain, which is an intracellular protease involved in many important cellular functions that are regulated by calcium [ , , , ]. The protein is a complex of 2 polypeptide chains (light and heavy), w... | [
"GO:0004198",
"GO:0006508"
] | [
"calcium-dependent cysteine-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE",
"SMART",
"CDD"
] | [
"PF00648",
"PS50203",
"SM00230",
"cd00044"
] | [
"Peptidase_C2",
"CALPAIN_CAT",
"CysPc",
"CysPc"
] | [
38023,
38214,
34617,
27740
] | 4 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.22",
"PDOC50203",
"R-BTA-1474228",
"R-BTA-9856530",
"R-BTA-9860927",
"R-CEL-6798695",
"R-DME-6798695",
"R-HSA-1474228",
"R-HSA-6798695",
"R-HSA-6809371",
"R-HSA-8862803",
"R-HSA-9856530",
"R-HSA-9860927",
"R-MMU-1474228",
"R-MMU-6798695",
"R-MMU-9856530",
"R-MMU-9860927",
"R-R... | [
"EC:3.4.22",
"PROSITEDOC:PDOC50203",
"REACTOME:R-BTA-1474228",
"REACTOME:R-BTA-9856530",
"REACTOME:R-BTA-9860927",
"REACTOME:R-CEL-6798695",
"REACTOME:R-DME-6798695",
"REACTOME:R-HSA-1474228",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-6809371",
"REACTOME:R-HSA-8862803",
"REACTOME:R-HSA-9856530... | 23 | [
"1df0",
"1kfu",
"1kfx",
"1kxr",
"1mdw",
"1qxp",
"1tl9",
"1tlo",
"1u5i",
"1zcm",
"1ziv",
"2ary",
"2g8e",
"2g8j",
"2nqa",
"2nqg",
"2nqi",
"2p0r",
"2r9c",
"2r9f",
"3bow",
"3df0",
"6bdt",
"6bgp",
"6bjd",
"6bkj",
"6p3q",
"7n6g",
"7sqc",
"7w7o",
"7x79",
"8gx3"... | 32 | [
"PUB00000551",
"PUB00002525",
"PUB00002542",
"PUB00003577",
"PUB00007140",
"PUB00011704",
"PUB00014535",
"PUB00018208",
"PUB00018209",
"PUB00018210",
"PUB00018211",
"PUB00020025",
"PUB00030423",
"PUB00076953",
"PUB00081543",
"PUB00081544",
"PUB00081545"
] | [
"9396712",
"2555341",
"2539381",
"7845226",
"11914728",
"11517925",
"12843408",
"11854009",
"11950589",
"10601010",
"11893336",
"9891971",
"14725770",
"7044372",
"11328585",
"11517928",
"21864727"
] | [
"Structure and physiological function of calpains.",
"Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle.",
"Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the la... | [
1997,
1989,
1989,
1994,
2002,
2001,
2003,
2002,
2002,
1999,
2002,
1998,
2004,
1982,
2001,
2001,
2012
] | 17 | [] | [] | 0 | 0 | null | [
"Aureococcus anophagefferens virus",
"Bacteria",
"Eukaryota",
"Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP)",
"metagenomes"
] | [
1,
864,
37608,
1,
13
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
17,
73,
11,
71,
53,
5,
4,
69,
1,
26
] | 11 | true | Domain | Peptidase C2, calpain, catalytic domain | Peptidase C2, calpain, catalytic domain | Peptidase_C2_calpain_cat | 9 |
IPR001301 | 1,301 | Geminivirus AL1 replication-associated protein, CLV type | Gemini_AL1_CLV | Family | 8,811 | false | false | Geminiviruses are characterised by a genome of circular single-stranded DNA encapsidated in twinned (geminate) quasi-isometric particles, from which the group derives its name [ ]. Most geminiviruses can be divided into two subgroups on the basis of host range and/or insect vector: i.e. those that infect dicotyledenous... | [
"GO:0005198"
] | [
"structural molecule activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR00228"
] | [
"GEMCOATCLVL1"
] | [
8811
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.-",
"3.1.21.-",
"PWY-6322",
"PWY-6626",
"PWY-6749",
"PWY-6955",
"PWY-6998",
"PWY-7127",
"PWY-7419",
"PWY-7529",
"PWY-7706",
"PWY-7719",
"PWY-7735",
"PWY-7737",
"PWY-7769",
"PWY-7888",
"PWY-7904",
"PWY-8117",
"PWY-8179"
] | [
"EC:2.7.7.-",
"EC:3.1.21.-",
"METACYC:PWY-6322",
"METACYC:PWY-6626",
"METACYC:PWY-6749",
"METACYC:PWY-6955",
"METACYC:PWY-6998",
"METACYC:PWY-7127",
"METACYC:PWY-7419",
"METACYC:PWY-7529",
"METACYC:PWY-7706",
"METACYC:PWY-7719",
"METACYC:PWY-7735",
"METACYC:PWY-7737",
"METACYC:PWY-7769",... | 19 | [
"1l2m",
"1l5i",
"6q1m",
"6we0",
"6we1",
"7kik",
"7vg8"
] | 7 | [
"PUB00001133",
"PUB00001145",
"PUB00003142",
"PUB00003143",
"PUB00004348",
"PUB00004397",
"PUB00005574",
"PUB00005578"
] | [
"6526009",
"16453696",
"1919519",
"1588314",
"2829117",
"1840676",
"1984668",
"1926771"
] | [
"The nucleotide sequence of maize streak virus DNA.",
"The nucleotide sequence of an infectious clone of the geminivirus beet curly top virus.",
"The nucleotide sequence and genome structure of the geminivirus miscanthus streak virus.",
"The nucleotide sequence of an infectious insect-transmissible clone of t... | [
1984,
1986,
1991,
1992,
1988,
1991,
1991,
1991
] | 8 | [
"IPR001191"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Viruses"
] | [
25,
207,
8579
] | 3 | [] | [] | 0 | true | Family | Geminivirus AL1 replication-associated protein, CLV type | Geminivirus AL1 replication-associated protein, CLV type | Gemini_AL1_CLV | 6 |
IPR001302 | 1,302 | Photosystem I reaction centre subunit VIII | PSI_PsaI | Family | 13,592 | false | false | Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria and in the thylakoid membranes of chloroplasts in plants and algae. Photosystem II (PSII) has a P680 reaction centre containing chlorophyll 'a' that uses light energy to carry out the oxidation (splitti... | [
"GO:0015979",
"GO:0009522"
] | [
"photosynthesis",
"photosystem I"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"HAMAP",
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"MF_00431",
"PF00796",
"PTHR35775",
"TIGR03052"
] | [
"PSI_PsaI",
"PSI_8",
"",
"PS_I_psaI"
] | [
13027,
13570,
12819,
13352
] | 4 | [
"GP",
"GP"
] | [
"GenProp0660",
"GenProp1353"
] | [
"GP:GenProp0660",
"GP:GenProp1353"
] | 2 | [
"1jb0",
"2o01",
"2wsc",
"2wse",
"2wsf",
"3lw5",
"3pcq",
"4fe1",
"4l6v",
"4rku",
"4xk8",
"4y28",
"5l8r",
"5oy0",
"5zf0",
"5zgb",
"5zgh",
"5zji",
"6fos",
"6hqb",
"6igz",
"6ijj",
"6ijo",
"6jeo",
"6jo5",
"6jo6",
"6k33",
"6k61",
"6kif",
"6kig",
"6kmw",
"6l35"... | 128 | [
"PUB00006297",
"PUB00006328",
"PUB00015098",
"PUB00152828"
] | [
"8262256",
"7608190",
"11418848",
"33846594"
] | [
"PsaL subunit is required for the formation of photosystem I trimers in the cyanobacterium Synechocystis sp. PCC 6803.",
"Mutational analysis of photosystem I polypeptides in the cyanobacterium Synechocystis sp. PCC 6803. Targeted inactivation of psaI reveals the function of psaI in the structural organization of... | [
1993,
1995,
2001,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
310,
13282
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
4,
2
] | 3 | true | Family | Photosystem I reaction centre subunit VIII | Photosystem I reaction centre subunit VIII | PSI_PsaI | 8 |
IPR001303 | 1,303 | Class II aldolase/adducin N-terminal | Aldolase_II/adducin_N | Domain | 71,604 | false | false | This entry represents the α/β/α domain found in class II aldolases and in adducin (usually at the N terminus of adducin). Proteins containing this domain include: rhamnulose-1-phosphate aldolase ( ), L-fuculose phosphate aldolase ( ) [ , ] that is involved in the third step in fucose metabolism, L-ribulose- 5-phosphate... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF00596",
"SM01007"
] | [
"Aldolase_II",
"Aldolase_II"
] | [
71602,
69714
] | 2 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp0458",
"R-BTA-111458",
"R-BTA-9627069",
"R-CEL-264870",
"R-CEL-5223345",
"R-CEL-9013405",
"R-CEL-9035034",
"R-DME-111458",
"R-DME-264870",
"R-DME-5223345",
"R-DME-9013405",
"R-DME-9035034",
"R-DME-9627069",
"R-DRE-111458",
"R-DRE-9627069",
"R-HSA-111458",
"R-HSA-1237112",
"... | [
"GP:GenProp0458",
"REACTOME:R-BTA-111458",
"REACTOME:R-BTA-9627069",
"REACTOME:R-CEL-264870",
"REACTOME:R-CEL-5223345",
"REACTOME:R-CEL-9013405",
"REACTOME:R-CEL-9035034",
"REACTOME:R-DME-111458",
"REACTOME:R-DME-264870",
"REACTOME:R-DME-5223345",
"REACTOME:R-DME-9013405",
"REACTOME:R-DME-9035... | 36 | [
"1dzu",
"1dzv",
"1dzw",
"1dzx",
"1dzy",
"1dzz",
"1e46",
"1e47",
"1e48",
"1e49",
"1e4a",
"1e4b",
"1e4c",
"1fua",
"1gt7",
"1jdi",
"1k0w",
"1ojr",
"1pvt",
"2fk5",
"2flf",
"2fua",
"2irp",
"2opi",
"2uyu",
"2uyv",
"2v29",
"2v2a",
"2v2b",
"2v9e",
"2v9f",
"2v9g"... | 58 | [
"PUB00003307",
"PUB00003364",
"PUB00056872",
"PUB00153682"
] | [
"8515438",
"8676381",
"1840603",
"36434094"
] | [
"The spatial structure of the class II L-fuculose-1-phosphate aldolase from Escherichia coli.",
"Catalytic mechanism of the metal-dependent fuculose aldolase from Escherichia coli as derived from the structure.",
"Primary structure and domain organization of human alpha and beta adducin.",
"A non-carboxylatin... | [
1993,
1996,
1991,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
653,
51768,
18312,
11,
860
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
11,
5,
76,
7,
6,
21,
18,
2,
1,
19,
1,
4,
6
] | 13 | true | Domain | Class II aldolase/adducin N-terminal | Class II aldolase/adducin N-terminal | Aldolase_II/adducin_N | 5 |
IPR001304 | 1,304 | C-type lectin-like | C-type_lectin-like | Domain | 134,941 | false | false | A number of different families of proteins share a conserved domain which was first characterised in some animal lectins and which seem to function as a calcium-dependent carbohydrate-recognition domain [ , ]. This domain, which is known as the C-type lectin domain (CTL) or as the carbohydrate-recognition domain (CRD),... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00059",
"PS50041",
"SM00034"
] | [
"Lectin_C",
"C_TYPE_LECTIN_2",
"CLECT"
] | [
121725,
131825,
120076
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00537",
"R-BTA-1482788",
"R-BTA-1482801",
"R-BTA-1482839",
"R-BTA-1482922",
"R-BTA-1482925",
"R-BTA-1483166",
"R-BTA-166016",
"R-BTA-166662",
"R-BTA-166663",
"R-BTA-1971475",
"R-BTA-198933",
"R-BTA-2022870",
"R-BTA-2022923",
"R-BTA-2024101",
"R-BTA-202733",
"R-BTA-3000178",
"R... | [
"PROSITEDOC:PDOC00537",
"REACTOME:R-BTA-1482788",
"REACTOME:R-BTA-1482801",
"REACTOME:R-BTA-1482839",
"REACTOME:R-BTA-1482922",
"REACTOME:R-BTA-1482925",
"REACTOME:R-BTA-1483166",
"REACTOME:R-BTA-166016",
"REACTOME:R-BTA-166662",
"REACTOME:R-BTA-166663",
"REACTOME:R-BTA-1971475",
"REACTOME:R-B... | 201 | [
"1afa",
"1afb",
"1afd",
"1b08",
"1b6e",
"1bch",
"1bcj",
"1bj3",
"1buu",
"1bv4",
"1byf",
"1c3a",
"1dv8",
"1e87",
"1e8i",
"1egg",
"1egi",
"1esl",
"1fif",
"1fih",
"1fm5",
"1fvu",
"1g1q",
"1g1r",
"1g1s",
"1g1t",
"1gz2",
"1h8u",
"1hq8",
"1htn",
"1hup",
"1hyr"... | 443 | [
"PUB00002490",
"PUB00004941",
"PUB00042644",
"PUB00042645",
"PUB00042881",
"PUB00042882",
"PUB00042883",
"PUB00081335",
"PUB00103664"
] | [
"3290208",
"8341801",
"15476922",
"14519388",
"18243268",
"16150695",
"14658760",
"16336259",
"28344595"
] | [
"Two distinct classes of carbohydrate-recognition domains in animal lectins.",
"Evolution of Ca(2+)-dependent animal lectins.",
"Divergent roles for C-type lectins expressed by cells of the innate immune system.",
"Dual function of C-type lectin-like receptors in the immune system.",
"Subunit structure and ... | [
1988,
1993,
2004,
2003,
2008,
2005,
2003,
2005,
2017
] | 9 | [] | [
"IPR033816",
"IPR033987",
"IPR033988",
"IPR033989",
"IPR033990",
"IPR033991",
"IPR033992",
"IPR034007",
"IPR034008",
"IPR034010",
"IPR034011"
] | 0 | 11 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
25,
1683,
132912,
247,
74
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
255,
451,
89,
252,
379,
4,
428,
2
] | 9 | true | Domain | C-type lectin-like | C-type lectin-like | C-type_lectin-like | 8 |
IPR001305 | 1,305 | Heat shock protein DnaJ, cysteine-rich domain | HSP_DnaJ_Cys-rich_dom | Domain | 55,131 | false | false | This entry represents the central cysteine-rich (CR) domain of DnaJ proteins. This central cysteine rich domain (CR-type zinc finger) has an overall V-shaped extended β-hairpin topology and contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent f... | [
"GO:0031072",
"GO:0051082"
] | [
"heat shock protein binding",
"unfolded protein binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"PROFILE",
"CDD"
] | [
"PF00684",
"PS51188",
"cd10719"
] | [
"DnaJ_CXXCXGXG",
"ZF_CR",
"DnaJ_zf"
] | [
52383,
52399,
53323
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00553",
"R-BTA-3371497",
"R-BTA-9841251",
"R-DDI-3371497",
"R-HSA-3371497",
"R-HSA-9841251",
"R-MMU-3371497",
"R-MMU-9841251",
"R-RNO-3371497",
"R-RNO-9841251",
"R-SCE-3371497",
"R-SCE-9841251",
"R-SPO-3371497",
"R-SPO-9841251"
] | [
"PROSITEDOC:PDOC00553",
"REACTOME:R-BTA-3371497",
"REACTOME:R-BTA-9841251",
"REACTOME:R-DDI-3371497",
"REACTOME:R-HSA-3371497",
"REACTOME:R-HSA-9841251",
"REACTOME:R-MMU-3371497",
"REACTOME:R-MMU-9841251",
"REACTOME:R-RNO-3371497",
"REACTOME:R-RNO-9841251",
"REACTOME:R-SCE-3371497",
"REACTOME:... | 14 | [
"1exk",
"1nlt",
"2ctt",
"6jzb",
"7zhs"
] | 5 | [
"PUB00014967",
"PUB00019436",
"PUB00020790",
"PUB00033831"
] | [
"15063739",
"10891270",
"15170475",
"11395418"
] | [
"cis-Effect of DnaJ on DnaK in ternary complexes with chimeric DnaK/DnaJ-binding peptides.",
"Solution structure of the cysteine-rich domain of the Escherichia coli chaperone protein DnaJ.",
"The J-protein family: modulating protein assembly, disassembly and translocation.",
"Folding of newly translated prote... | [
2004,
2000,
2004,
2001
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
945,
30204,
23158,
75,
749
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
42,
3,
12,
17,
1,
15,
16,
4,
29,
19,
5,
4,
127
] | 13 | true | Domain | Heat shock protein DnaJ, cysteine-rich domain | Heat shock protein DnaJ, cysteine-rich domain | HSP_DnaJ_Cys-rich_dom | 7 |
IPR001308 | 1,308 | Electron transfer flavoprotein alpha subunit/FixB | ETF_a/FixB | Family | 35,815 | false | false | This entry includes electron transfer flavoprotein alpha subunit and the FixB protein. Electron transfer flavoproteins (ETFs) serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. They can be functionally classified into constitutive, "housekeeping"... | [
"GO:0009055",
"GO:0050660"
] | [
"electron transfer activity",
"flavin adenine dinucleotide binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF000089",
"PTHR43153"
] | [
"Electra_flavoP_a",
""
] | [
30583,
35815
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-611105",
"R-DDI-611105",
"R-HSA-611105",
"R-MMU-611105",
"R-RNO-611105",
"R-SCE-611105",
"R-SPO-611105"
] | [
"REACTOME:R-CEL-611105",
"REACTOME:R-DDI-611105",
"REACTOME:R-HSA-611105",
"REACTOME:R-MMU-611105",
"REACTOME:R-RNO-611105",
"REACTOME:R-SCE-611105",
"REACTOME:R-SPO-611105"
] | 7 | [
"1efp",
"1efv",
"1o94",
"1o95",
"1o96",
"1o97",
"1t9g",
"2a1t",
"2a1u",
"3clr",
"3cls",
"3clt",
"3clu",
"3ih5",
"4kpu",
"4l2i",
"5ol2",
"5ow0",
"6fah",
"7koe",
"7qh2"
] | 21 | [
"PUB00003866",
"PUB00004879",
"PUB00004936",
"PUB00005086",
"PUB00024527",
"PUB00033231",
"PUB00033232",
"PUB00053911",
"PUB00054253"
] | [
"7815937",
"8962055",
"2326318",
"8525056",
"10026281",
"8599534",
"12567183",
"9037756",
"12081978"
] | [
"Molecular characterization of the cai operon necessary for carnitine metabolism in Escherichia coli.",
"Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution.",
"Biosynthesis, molecular cloning and sequencing of electron transfer flavoprotein.",
"Phylogenetic characterizatio... | [
1994,
1996,
1990,
1995,
1999,
1996,
2003,
1997,
2002
] | 9 | [] | [
"IPR023461",
"IPR050041"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
895,
28890,
5255,
775
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
2,
1,
1,
2,
3,
18,
1,
1,
1,
4,
1,
1,
18
] | 13 | true | Family | Electron transfer flavoprotein alpha subunit/FixB | Electron transfer flavoprotein alpha subunit/FixB | ETF_a/FixB | 3 |
IPR001309 | 1,309 | Peptidase C14, p20 domain | Pept_C14_p20 | Domain | 29,703 | false | false | This group of sequences represent the p20 subunit found in caspases. Caspases are composed of an N-terminal pro-domain that is cleaved during activation, and C-terminal catalytic and interaction domains [ ]. All caspases contain two essential caspase catalytic domains: the p20 subunit (20kDa) and the p10 subunit (10kDa... | [
"GO:0004197",
"GO:0006508"
] | [
"cysteine-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROFILE"
] | [
"PS50208"
] | [
"CASPASE_P20"
] | [
29703
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.22",
"PDOC00864",
"R-BTA-5620971",
"R-CEL-111465",
"R-CEL-140342",
"R-CEL-198323",
"R-CEL-2028269",
"R-CEL-264870",
"R-CEL-351906",
"R-CEL-418889",
"R-CEL-5357905",
"R-DME-111458",
"R-DME-111459",
"R-DME-111465",
"R-DME-111469",
"R-DME-140342",
"R-DME-198323",
"R-DME-2028269",... | [
"EC:3.4.22",
"PROSITEDOC:PDOC00864",
"REACTOME:R-BTA-5620971",
"REACTOME:R-CEL-111465",
"REACTOME:R-CEL-140342",
"REACTOME:R-CEL-198323",
"REACTOME:R-CEL-2028269",
"REACTOME:R-CEL-264870",
"REACTOME:R-CEL-351906",
"REACTOME:R-CEL-418889",
"REACTOME:R-CEL-5357905",
"REACTOME:R-DME-111458",
"R... | 154 | [
"1bmq",
"1cp3",
"1f1j",
"1f9e",
"1gfw",
"1gqf",
"1i3o",
"1i4e",
"1i4o",
"1i51",
"1ibc",
"1ice",
"1jxq",
"1k86",
"1k88",
"1kmc",
"1m72",
"1nme",
"1nmq",
"1nms",
"1nw9",
"1pau",
"1pyo",
"1qdu",
"1qtn",
"1qx3",
"1re1",
"1rhj",
"1rhk",
"1rhm",
"1rhq",
"1rhr"... | 342 | [
"PUB00014747",
"PUB00014748",
"PUB00015006",
"PUB00015057"
] | [
"15077141",
"15066636",
"10578171",
"15226512"
] | [
"Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies.",
"Death without caspases, caspases without death.",
"Caspase structure, proteolytic substrates, and function during apoptotic cell death.",
"The domains of apoptosis: a genomics perspective."
] | [
2004,
2004,
1999,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
7,
4963,
24687,
9,
37
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
62,
11,
63,
41,
54
] | 6 | true | Domain | Peptidase C14, p20 domain | Peptidase C14, p20 domain | Pept_C14_p20 | 2 |
IPR001310 | 1,310 | Histidine triad (HIT) protein | Histidine_triad_HIT | Family | 45,908 | false | false | The Histidine Triad (HIT) motif, His-x-His-x-His-x-x (x, a hydrophobic amino acid) was identified as being highly conserved in a variety of organisms [ , ]. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consis... | [] | [] | [] | 0 | [
"PRINTS",
"PANTHER",
"PANTHER"
] | [
"PR00332",
"PTHR23089",
"PTHR46648"
] | [
"HISTRIAD",
"",
""
] | [
41439,
20025,
22272
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00694",
"R-BTA-9013405",
"R-CEL-9824594",
"R-CEL-9825892",
"R-CEL-9856649",
"R-HSA-9013405",
"R-HSA-9824594",
"R-HSA-9825892",
"R-HSA-9856649",
"R-MMU-9013405",
"R-MMU-9824594",
"R-MMU-9825892",
"R-MMU-9856649",
"R-RNO-9824594",
"R-RNO-9825892",
"R-RNO-9856649"
] | [
"PROSITEDOC:PDOC00694",
"REACTOME:R-BTA-9013405",
"REACTOME:R-CEL-9824594",
"REACTOME:R-CEL-9825892",
"REACTOME:R-CEL-9856649",
"REACTOME:R-HSA-9013405",
"REACTOME:R-HSA-9824594",
"REACTOME:R-HSA-9825892",
"REACTOME:R-HSA-9856649",
"REACTOME:R-MMU-9013405",
"REACTOME:R-MMU-9824594",
"REACTOME:... | 16 | [
"1av5",
"1kpa",
"1kpb",
"1kpc",
"1kpe",
"1kpf",
"1rzy",
"1y23",
"2eo4",
"3imi",
"3ksv",
"3l7x",
"3lb5",
"3n1s",
"3n1t",
"3o0m",
"3o1c",
"3o1x",
"3o1z",
"3oj7",
"3omf",
"3oxk",
"3p0t",
"3qgz",
"3r6f",
"3rhn",
"3tw2",
"4egu",
"4eqe",
"4eqg",
"4eqh",
"4inc"... | 99 | [
"PUB00001122",
"PUB00003940",
"PUB00005228",
"PUB00008002",
"PUB00008005",
"PUB00015781",
"PUB00089564",
"PUB00099578"
] | [
"1472710",
"9164465",
"9323207",
"11805111",
"12119013",
"12473516",
"12432269",
"15703176"
] | [
"The HIT protein family: a new family of proteins present in prokaryotes, yeast and mammals.",
"Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins.",
"Structure-based analysis of catalysis and substrate definition in the HIT protein family.",
"Ade... | [
1992,
1997,
1997,
2002,
2002,
2002,
2002,
2005
] | 8 | [] | [
"IPR026026",
"IPR039384"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
924,
33130,
11146,
23,
685
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
20,
1,
8,
2,
1,
11,
4,
2,
16,
7,
1,
2,
15
] | 13 | true | Family | Histidine triad (HIT) protein | Histidine triad (HIT) protein | Histidine_triad_HIT | 2 |
IPR001312 | 1,312 | Hexokinase | Hexokinase | Family | 22,954 | false | false | Hexokinase ( ) [ , ] is an important glycolytic enzyme that catalyses the phosphorylation of keto- and aldohexoses (e.g. glucose, mannose and fructose) using MgATP as the phosphoryl donor. In vertebrates there are four major isoenzymes, commonly referred as types I, II, III and IV. Type IV hexokinase, which is often in... | [
"GO:0004396",
"GO:0005524",
"GO:0005536",
"GO:0001678",
"GO:0005975"
] | [
"hexokinase activity",
"ATP binding",
"D-glucose binding",
"intracellular glucose homeostasis",
"carbohydrate metabolic process"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 5 | [
"PROFILE",
"PANTHER"
] | [
"PS51748",
"PTHR19443"
] | [
"HEXOKINASE_2",
""
] | [
22438,
22799
] | 2 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.1.1",
"PDOC00370",
"R-DME-170822",
"R-DME-446205",
"R-DME-6798695",
"R-DME-70171",
"R-HSA-170822",
"R-HSA-210745",
"R-HSA-446205",
"R-HSA-5619056",
"R-HSA-5619073",
"R-HSA-5619107",
"R-HSA-6798695",
"R-HSA-70171",
"R-HSA-9615017",
"R-MMU-170822",
"R-MMU-446205",
"R-MMU-6798695... | [
"EC:2.7.1.1",
"PROSITEDOC:PDOC00370",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-446205",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-70171",
"REACTOME:R-HSA-170822",
"REACTOME:R-HSA-210745",
"REACTOME:R-HSA-446205",
"REACTOME:R-HSA-5619056",
"REACTOME:R-HSA-5619073",
"REACTOME:R-HSA-5619107",
"... | 31 | [
"1bdg",
"1bg3",
"1cza",
"1dgk",
"1hkb",
"1hkc",
"1hkg",
"1ig8",
"1qha",
"1v4s",
"1v4t",
"2nzt",
"2yhx",
"3a0i",
"3b8a",
"3f9m",
"3fgu",
"3fr0",
"3goi",
"3h1v",
"3hm8",
"3id8",
"3idh",
"3imx",
"3o08",
"3o1b",
"3o1w",
"3o4w",
"3o5b",
"3o6w",
"3o80",
"3o8m"... | 89 | [
"PUB00000147",
"PUB00000566",
"PUB00001951",
"PUB00005375",
"PUB00014215",
"PUB00036888"
] | [
"3579310",
"2199258",
"1783373",
"1957348",
"10749890",
"9493266"
] | [
"Rat brain hexokinase: location of the substrate hexose binding site in a structural domain at the C-terminus of the enzyme.",
"Hexokinases and glucokinases.",
"Mammalian hexokinase 1: evolutionary conservation and structure to function analysis.",
"Hexokinase and 'glucokinase' in liver metabolism.",
"The h... | [
1987,
1990,
1991,
1991,
2000,
1998
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
432,
22513,
9
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
32,
6,
8,
16,
55,
28,
5,
29,
37,
5,
2,
52
] | 12 | true | Family | Hexokinase | Hexokinase | Hexokinase | 3 |
IPR001313 | 1,313 | Pumilio RNA-binding repeat | Pumilio_RNA-bd_rpt | Repeat | 34,346 | false | false | Members of the Pumilio family of proteins (Puf) regulate translation and mRNA stability in a wide variety of eukaryotic organisms including mammals, flies, worms, slime mold, and yeast [ ]. Pumilio family members are characterised by the presence of eight tandem copies of an imperfectly repeated 36 amino acids sequence... | [
"GO:0003723"
] | [
"RNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00806",
"PF22493",
"PS50302",
"SM00025"
] | [
"PUF",
"PUF_NOP9",
"PUM",
"Pumilio"
] | [
25645,
5682,
29816,
32592
] | 4 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC50302",
"R-GGA-432722",
"R-HSA-432722",
"R-HSA-8951664",
"R-MMU-432722"
] | [
"PROSITEDOC:PDOC50302",
"REACTOME:R-GGA-432722",
"REACTOME:R-HSA-432722",
"REACTOME:R-HSA-8951664",
"REACTOME:R-MMU-432722"
] | 5 | [
"1ib2",
"1m8w",
"1m8x",
"1m8y",
"1m8z",
"2yjy",
"3bsb",
"3bsx",
"3bwt",
"3bx2",
"3bx3",
"3gvo",
"3gvt",
"3h3d",
"3k49",
"3k4e",
"3k5q",
"3k5y",
"3k5z",
"3k61",
"3k62",
"3k64",
"3q0l",
"3q0m",
"3q0n",
"3q0o",
"3q0p",
"3q0q",
"3q0r",
"3q0s",
"3qg9",
"3qgb"... | 78 | [
"PUB00018238",
"PUB00018239",
"PUB00018240",
"PUB00018241",
"PUB00018242",
"PUB00050752",
"PUB00050806",
"PUB00052211",
"PUB00057141",
"PUB00094378"
] | [
"10662662",
"14584586",
"1459455",
"11336708",
"12202039",
"18328718",
"18327269",
"19540345",
"21653694",
"29385744"
] | [
"Translational repression: a duet of Nanos and Pumilio.",
"The PUF family of RNA-binding proteins: does evolutionarily conserved structure equal conserved function?",
"Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos.",
"Crystal structure of a Pumilio ho... | [
2000,
2003,
1992,
2001,
2002,
2008,
2008,
2009,
2011,
2018
] | 10 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Orthopoxvirus",
"metagenomes"
] | [
8,
257,
34000,
67,
14
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
115,
11,
11,
13,
21,
22,
7,
60,
20,
7,
9,
129
] | 12 | true | Repeat | Pumilio RNA-binding repeat | Pumilio RNA-binding repeat | Pumilio_RNA-bd_rpt | 8 |
IPR001314 | 1,314 | Peptidase S1A, chymotrypsin family | Peptidase_S1A | Family | 160,610 | false | false | This group of serine peptidases and non-peptidase homologues belong to the MEROPS peptidase family S1, subfamily S1A (chymotrypsin subfamily, clan PA(S)). These peptidases contain the catalytic triad histidine, aspartate and serine found in all members of subfamily S1A. Testes-specific protein TSP50 is also included in... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR00722"
] | [
"CHYMOTRYPSIN"
] | [
160610
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.21",
"R-BTA-114608",
"R-BTA-140834",
"R-BTA-140837",
"R-BTA-1592389",
"R-BTA-159740",
"R-BTA-159763",
"R-BTA-159782",
"R-BTA-166663",
"R-BTA-173736",
"R-BTA-174577",
"R-BTA-6798695",
"R-BTA-75205",
"R-BTA-977606",
"R-CFA-114608",
"R-CFA-1257604",
"R-CFA-140875",
"R-CFA-1433557... | [
"EC:3.4.21",
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-140834",
"REACTOME:R-BTA-140837",
"REACTOME:R-BTA-1592389",
"REACTOME:R-BTA-159740",
"REACTOME:R-BTA-159763",
"REACTOME:R-BTA-159782",
"REACTOME:R-BTA-166663",
"REACTOME:R-BTA-173736",
"REACTOME:R-BTA-174577",
"REACTOME:R-BTA-6798695",
"R... | 243 | [
"1a0h",
"1a0j",
"1a0l",
"1a2c",
"1a3b",
"1a3e",
"1a46",
"1a4w",
"1a5g",
"1a5h",
"1a5i",
"1a61",
"1a7s",
"1ab9",
"1abi",
"1abj",
"1acb",
"1ad8",
"1ae5",
"1ae8",
"1afe",
"1afq",
"1aht",
"1ai8",
"1aix",
"1aks",
"1amh",
"1an1",
"1anb",
"1anc",
"1and",
"1ane"... | 2,586 | [
"PUB00003576",
"PUB00095105"
] | [
"7845208",
"17283160"
] | [
"Families of serine peptidases.",
"TSP50 encodes a testis-specific protease and is negatively regulated by p53."
] | [
1994,
2007
] | 2 | [] | [
"IPR003966",
"IPR008292",
"IPR011163",
"IPR011360",
"IPR012224",
"IPR012267",
"IPR014394",
"IPR017118",
"IPR017324",
"IPR017326",
"IPR017327",
"IPR017329",
"IPR023317",
"IPR024174",
"IPR024175"
] | 0 | 15 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"metagenomes"
] | [
13108,
147372,
7,
25,
98
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
261,
486,
465,
336,
494
] | 6 | true | Family | Peptidase S1A, chymotrypsin family | Peptidase S1A, chymotrypsin family | Peptidase_S1A | 6 |
IPR001315 | 1,315 | CARD domain | CARD | Domain | 30,543 | false | false | The caspase recruitment domain (CARD domain) is a homotypic protein interaction module composed of a bundle of six α-helices. CARD is related in sequence and structure to the death domain (DD, see ) and the death effector domain (DED, see ), which work in similar pathways and show similar interaction properties [ ]. Th... | [
"GO:0042981"
] | [
"regulation of apoptotic process"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF00619",
"PS50209",
"SM00114"
] | [
"CARD",
"CARD",
"CARD"
] | [
27275,
29925,
8509
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC50209",
"R-BTA-168638",
"R-BTA-202424",
"R-BTA-209543",
"R-BTA-450302",
"R-BTA-450321",
"R-BTA-5620971",
"R-BTA-5689896",
"R-CEL-111465",
"R-CEL-140342",
"R-CEL-198323",
"R-CEL-2028269",
"R-CEL-264870",
"R-CEL-351906",
"R-CEL-418889",
"R-CEL-5357905",
"R-CFA-168638",
"R-CFA-53... | [
"PROSITEDOC:PDOC50209",
"REACTOME:R-BTA-168638",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-209543",
"REACTOME:R-BTA-450302",
"REACTOME:R-BTA-450321",
"REACTOME:R-BTA-5620971",
"REACTOME:R-BTA-5689896",
"REACTOME:R-CEL-111465",
"REACTOME:R-CEL-140342",
"REACTOME:R-CEL-198323",
"REACTOME:R-CEL-20... | 144 | [
"1c15",
"1cww",
"1cy5",
"1dgn",
"1z6t",
"2a5y",
"2b1w",
"2dbd",
"2kn6",
"2l9m",
"2mb9",
"2mn4",
"2n7z",
"2n83",
"2nsn",
"2nz7",
"2p1h",
"2ygs",
"3crd",
"3j2t",
"3jbt",
"3kat",
"3lqq",
"3lqr",
"3sfz",
"3shf",
"3t6p",
"3ygs",
"4e9m",
"4i16",
"4ifp",
"4ikm"... | 92 | [
"PUB00005464",
"PUB00014109",
"PUB00015013",
"PUB00015057",
"PUB00097958"
] | [
"9175472",
"12101092",
"11504623",
"15226512",
"22065589"
] | [
"The CARD domain: a new apoptotic signalling motif.",
"CARD games in apoptosis and immunity.",
"The death domain superfamily: a tale of two interfaces?",
"The domains of apoptosis: a genomics perspective.",
"Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactio... | [
1997,
2002,
2001,
2004,
2011
] | 5 | [] | [
"IPR033516",
"IPR035702",
"IPR037963",
"IPR042140",
"IPR042141",
"IPR042142",
"IPR042143",
"IPR042147",
"IPR042148",
"IPR042149"
] | 0 | 10 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
21,
306,
30139,
70,
7
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
151,
115,
81,
117
] | 5 | true | Domain | CARD domain | CARD domain | CARD | 9 |
IPR001316 | 1,316 | Peptidase S1A, streptogrisin | Pept_S1A_streptogrisin | Family | 8,420 | false | false | This group of serine peptidases belong to the MEROPS peptidase family S1, subfamily S1E (streptogrisin A subfamily, clan PA(S)). A type example is streptogrisin A from Streptomyces griseus [ ]. | [
"GO:0004252",
"GO:0006508"
] | [
"serine-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF001134",
"PR00861"
] | [
"Streptogrisin",
"ALYTICPTASE"
] | [
6282,
8393
] | 2 | [] | [] | [] | 0 | [
"1boq",
"1cso",
"1ct0",
"1ct2",
"1ct4",
"1ds2",
"1gba",
"1gbb",
"1gbc",
"1gbd",
"1gbe",
"1gbf",
"1gbh",
"1gbi",
"1gbj",
"1gbk",
"1gbl",
"1gbm",
"1hpg",
"1p01",
"1p02",
"1p03",
"1p04",
"1p05",
"1p06",
"1p09",
"1p10",
"1p11",
"1p12",
"1qq4",
"1qrw",
"1qrx"... | 91 | [
"PUB00085122"
] | [
"3112129"
] | [
"Characterization and structure of genes for proteases A and B from Streptomyces griseus."
] | [
1987
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"ecological metagenomes"
] | [
8175,
223,
11,
11
] | 4 | [] | [] | 0 | true | Family | Peptidase S1A, streptogrisin | Peptidase S1A, streptogrisin | Pept_S1A_streptogrisin | 6 |
IPR001318 | 1,318 | Inhibin, beta C subunit | Inhibin_betaC | Family | 940 | false | false | Inhibins and activins are glycoproteins, secreted by the gonads, that belong to the transforming growth factor beta family [ ]. They participate in differentiation and growth of diverse cell types. Inhibin inhibits secretion of follicle-stimulating hormone by the pituitary [ ]. Inhibin has two isoforms, A and B, with t... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR00672"
] | [
"INHIBINBC"
] | [
940
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-209822",
"R-MMU-209822",
"R-RNO-209822"
] | [
"REACTOME:R-HSA-209822",
"REACTOME:R-MMU-209822",
"REACTOME:R-RNO-209822"
] | 3 | [] | 0 | [
"PUB00001456",
"PUB00003992",
"PUB00006558",
"PUB00006578"
] | [
"7813465",
"2417121",
"9207855",
"9989858"
] | [
"Genomic cloning and sequence analyses of the bovine alpha-, beta A- and beta B-inhibin/activin genes. Identification of transcription factor AP-2-binding sites in the 5'-flanking regions by DNase I footprinting.",
"Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homol... | [
1994,
1985,
1997,
1998
] | 4 | [
"IPR015615"
] | [] | 1 | 0 | 1 | [
"Chordata"
] | [
940
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
3,
5
] | 4 | true | Family | Inhibin, beta C subunit | Inhibin, beta C subunit | Inhibin_betaC | 8 |
IPR001319 | 1,319 | Nuclear transition protein 1 | Nuclear_transition_prot1 | Family | 159 | false | false | Nuclear transition protein 1 (TP1) is one of the spermatid-specific proteins [ ]. TP1 is a basic protein well conserved in mammalian species. In mammals, the second stage of spermatogenesis is characterised by the conversion of nucleosomal chromatin to the compact, non-nucleosomal and transcriptionally inactive form fo... | [
"GO:0003677",
"GO:0007283",
"GO:0000786",
"GO:0005634"
] | [
"DNA binding",
"spermatogenesis",
"nucleosome",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PFAM",
"PANTHER"
] | [
"PF02079",
"PTHR17486"
] | [
"TP1",
""
] | [
159,
159
] | 2 | [
"PROSITEDOC"
] | [
"PDOC00467"
] | [
"PROSITEDOC:PDOC00467"
] | 1 | [] | 0 | [
"PUB00001393"
] | [
"2040274"
] | [
"Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants."
] | [
1991
] | 1 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
159
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
3
] | 3 | true | Family | Nuclear transition protein 1 | Nuclear transition protein 1 | Nuclear_transition_prot1 | 8 |
IPR001320 | 1,320 | Ionotropic glutamate receptor, C-terminal | Iontro_rcpt_C | Domain | 101,171 | false | false | There are three classes of ionotropic glutamate receptors (iGluRs), namely NMDA (N-methyl-D-aspartate), AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid) and kainate receptors. They are believed to play critical roles in synaptic plasticity. At many synapses in the brain, transient activation of NMDA r... | [
"GO:0015276",
"GO:0016020"
] | [
"ligand-gated monoatomic ion channel activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"SMART"
] | [
"PF00060",
"SM00079"
] | [
"Lig_chan",
"PBPe"
] | [
63268,
91142
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-204005",
"R-CEL-399710",
"R-CEL-438066",
"R-CEL-5694530",
"R-CEL-8849932",
"R-CFA-3928662",
"R-CFA-438066",
"R-CFA-5673001",
"R-CFA-8849932",
"R-CFA-9609736",
"R-DME-204005",
"R-DME-3928662",
"R-DME-399710",
"R-DME-416993",
"R-DME-438066",
"R-DME-5694530",
"R-DME-8849932",
"... | [
"REACTOME:R-CEL-204005",
"REACTOME:R-CEL-399710",
"REACTOME:R-CEL-438066",
"REACTOME:R-CEL-5694530",
"REACTOME:R-CEL-8849932",
"REACTOME:R-CFA-3928662",
"REACTOME:R-CFA-438066",
"REACTOME:R-CFA-5673001",
"REACTOME:R-CFA-8849932",
"REACTOME:R-CFA-9609736",
"REACTOME:R-DME-204005",
"REACTOME:R-D... | 63 | [
"1ftj",
"1ftk",
"1ftl",
"1ftm",
"1fto",
"1fw0",
"1ggg",
"1gr2",
"1ii5",
"1iit",
"1iiw",
"1lb8",
"1lb9",
"1lbb",
"1lbc",
"1m5b",
"1m5c",
"1m5d",
"1m5e",
"1m5f",
"1mm6",
"1mm7",
"1mqd",
"1mqg",
"1mqh",
"1mqi",
"1mqj",
"1ms7",
"1mxu",
"1mxv",
"1mxw",
"1mxx"... | 851 | [
"PUB00006459",
"PUB00072709",
"PUB00072710"
] | [
"10580501",
"14977400",
"20808886"
] | [
"Kainate receptors are involved in synaptic plasticity.",
"Structure and function of glutamate receptor ion channels.",
"Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction."
] | [
1999,
2004,
2010
] | 3 | [] | [
"IPR044132",
"IPR049872"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviricetes",
"unclassified sequences"
] | [
276,
35308,
65433,
3,
151
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
131,
20,
236,
65,
4,
99,
77,
70,
104,
86
] | 10 | true | Domain | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, C-terminal | Iontro_rcpt_C | 3 |
IPR001322 | 1,322 | Lamin tail domain | Lamin_tail_dom | Domain | 24,518 | false | false | Intermediate filaments (IFs) constitute a major structural element of metazoan cells. They build two distinct systems: one inside the nucleus attached to the inner membrane, and one that is cytoplasmic, which connects intercellular junctional complexes situated at the plasma membrane with the outer nuclear membrane. In... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF00932",
"PS51841"
] | [
"LTD",
"LTD"
] | [
21788,
23709
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-2559584",
"R-CEL-4419969",
"R-CEL-9013405",
"R-CEL-9035034",
"R-DME-4419969",
"R-DME-9013405",
"R-DME-9035034",
"R-HSA-1221632",
"R-HSA-2559584",
"R-HSA-2980766",
"R-HSA-2995383",
"R-HSA-352238",
"R-HSA-381038",
"R-HSA-4419969",
"R-HSA-6802952",
"R-HSA-8862803",
"R-HSA-8950505... | [
"REACTOME:R-CEL-2559584",
"REACTOME:R-CEL-4419969",
"REACTOME:R-CEL-9013405",
"REACTOME:R-CEL-9035034",
"REACTOME:R-DME-4419969",
"REACTOME:R-DME-9013405",
"REACTOME:R-DME-9035034",
"REACTOME:R-HSA-1221632",
"REACTOME:R-HSA-2559584",
"REACTOME:R-HSA-2980766",
"REACTOME:R-HSA-2995383",
"REACTOM... | 32 | [
"1ifr",
"1ivt",
"1ufg",
"2kpw",
"2lll",
"3gef",
"3jt0",
"3umn",
"6ghd",
"6rpr",
"7crg",
"7dtg",
"7yvd",
"7z21",
"9j8m",
"9j8n",
"9j8o"
] | 17 | [
"PUB00026148",
"PUB00057231",
"PUB00088683",
"PUB00088684",
"PUB00088685"
] | [
"12057196",
"15611647",
"17551517",
"1794458",
"22265972"
] | [
"The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy.",
"Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex.",
"Intermediate filaments: from cell architecture to nanomechanics.",
"Aspe... | [
2002,
2004,
2007,
1991,
2012
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
826,
14520,
8697,
475
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
8,
4,
19,
14,
29
] | 6 | true | Domain | Lamin tail domain | Lamin tail domain | Lamin_tail_dom | 9 |
IPR001323 | 1,323 | Erythropoietin/thrombopoietin | EPO_TPO | Family | 1,717 | false | false | Erythropoietin, a plasma glycoprotein, is the primary physiological mediator of erythropoiesis [ ]. It is involved in the regulation of the level of peripheral erythrocytes by stimulating the differentiation of erythroid progenitor cells, found in the spleen and bone marrow, into mature erythrocytes [ ]. It is primaril... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF00758"
] | [
"EPO_TPO"
] | [
1717
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00644",
"R-BTA-9027276",
"R-BTA-9027284",
"R-HSA-1234158",
"R-HSA-76009",
"R-HSA-9006335",
"R-HSA-9027276",
"R-HSA-9027277",
"R-HSA-9027283",
"R-HSA-9027284",
"R-MMU-9027276",
"R-MMU-9027284",
"R-RNO-9027276",
"R-RNO-9027284",
"R-SSC-9027276",
"R-SSC-9027284"
] | [
"PROSITEDOC:PDOC00644",
"REACTOME:R-BTA-9027276",
"REACTOME:R-BTA-9027284",
"REACTOME:R-HSA-1234158",
"REACTOME:R-HSA-76009",
"REACTOME:R-HSA-9006335",
"REACTOME:R-HSA-9027276",
"REACTOME:R-HSA-9027277",
"REACTOME:R-HSA-9027283",
"REACTOME:R-HSA-9027284",
"REACTOME:R-MMU-9027276",
"REACTOME:R-... | 16 | [
"1buy",
"1cn4",
"1eer",
"1v7m",
"1v7n",
"8g04",
"8u18",
"8vu5"
] | 8 | [
"PUB00000639",
"PUB00001756",
"PUB00002479",
"PUB00003648"
] | [
"1420369",
"2877922",
"3346214",
"3773894"
] | [
"Nucleotide sequence of rat erythropoietin.",
"Monkey erythropoietin gene: cloning, expression and comparison with the human erythropoietin gene.",
"Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary ce... | [
1992,
1986,
1988,
1986
] | 4 | [] | [
"IPR003013",
"IPR003978"
] | 0 | 2 | 0 | [
"Gnathostomata"
] | [
1717
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
10,
7,
7
] | 4 | true | Family | Erythropoietin/thrombopoietin | Erythropoietin/thrombopoietin | EPO_TPO | 4 |
IPR001325 | 1,325 | Interleukin-4/interleukin-13 | IL-4/IL-13 | Family | 696 | false | false | null | [
"GO:0005126",
"GO:0006955",
"GO:0005576"
] | [
"cytokine receptor binding",
"immune response",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"SMART"
] | [
"SM00190"
] | [
"IL4_13"
] | [
696
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00655",
"R-BTA-6785807",
"R-CFA-6785807",
"R-HSA-6785807",
"R-HSA-9012546",
"R-MMU-6785807",
"R-RNO-6785807",
"R-SSC-6785807"
] | [
"PROSITEDOC:PDOC00655",
"REACTOME:R-BTA-6785807",
"REACTOME:R-CFA-6785807",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-9012546",
"REACTOME:R-MMU-6785807",
"REACTOME:R-RNO-6785807",
"REACTOME:R-SSC-6785807"
] | 8 | [
"1bbn",
"1bcn",
"1cyl",
"1ga3",
"1hij",
"1hik",
"1hzi",
"1iar",
"1ijz",
"1ik0",
"1iti",
"1itl",
"1itm",
"1rcb",
"2b8u",
"2b8x",
"2b8y",
"2b8z",
"2b90",
"2b91",
"2cyk",
"2d48",
"2int",
"3bpl",
"3bpn",
"3bpo",
"3g6d",
"3l5w",
"3l5x",
"3lb6",
"3qb7",
"4i77"... | 44 | [
"PUB00000107",
"PUB00000339",
"PUB00002013",
"PUB00004143"
] | [
"1693082",
"1993171",
"3284813",
"8096327"
] | [
"Lymphokine control of in vivo immunoglobulin isotype selection.",
"Disulfide assignments in recombinant mouse and human interleukin 4.",
"Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells.",
"Interleukin-13 is a new ... | [
1990,
1991,
1988,
1993
] | 4 | [] | [
"IPR002354",
"IPR020470"
] | 0 | 2 | 0 | [
"Euteleostomi"
] | [
696
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
3,
6
] | 3 | true | Family | Interleukin-4/interleukin-13 | Interleukin-4/interleukin-13 | IL-4/IL-13 | 4 |
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