id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
values | statement_pol stringclasses 50
values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
values |
|---|---|---|---|---|---|---|---|
5,256 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
1. women osteoporosis
2. patients with a diagnosis of Postmenopausal over 6 Months if they had a bone mineral
density T-score of < -2.5 at the mean lumbar spine (L1-4), femoral neck, or total, or
a T-score of < -1.0 with radiologic evidence of at least... | Post-menopausal Women Osteoporosis(Phase III) | NCT01806792 | Entailment |
608 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- tubal pregnancy
- tubal pregnancy except interstitial pregnancy
- a pretreatment β-hCG level <15000 mIU/mL
- a gestational sac with a largest diameter <4 cm
- hemodynamically stable status
- agreement to methotrexate treatment... | Methotrexate Treatment for Ectopic Pregnancy | NCT01855568 | Entailment |
5,930 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Clinically obese or morbid obese males and females aged 14 - 19 years old (BMI > 3.5
SD)
- Are able to attend biweekly to monthly sessions with our support team and are capable
of adhering to the lifestyle changes advised
Exclusion Criteri... | Effectiveness Gastric Balloon in Obese Adolescents | NCT04209842 | Contradiction |
4,513 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Healthy, women 18 through 40 years of age at the time of enrollment who have severe
menstrual related symptoms
- Willing and able to comply with the study protocol
- Has not used oral contraceptives, vaginal rings, or injectable contraceptives durin... | Continuous Use of the Contraceptive Patch and the Personal Economic Impact. | NCT00357981 | Contradiction |
2,339 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Subject Inclusion Criteria
1. 5 to 10 years of age
2. ambulatory
3. diagnosis of DMD confirmed by at least one of the following:
- Positive x-linked family history of DMD in older male relatives (onset by 5
years, wheelchair bound by 12 years), or;
... | KUL0401: An Open-label Pilot Study of Oxatomide in Steroid-Naive Duchenne Muscular Dystrophy | NCT00033813 | Entailment |
4,784 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
1. Patients with age between 20 to 80-year-old who can cooperate to the whole treatment,
testing and questionnaire.
2. The chief complaint is dizziness which diagnosed by the doctor in charge of the
emergency department, in together to exclude the pati... | The Efficacy and Safety of Traditional Chinese Medicine (TCM) to the Patient With Dizziness in Emergency Department | NCT04415307 | Entailment |
493 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Patient's preparing for invitro fertilization and embryo transfer with endometrial
growth of less than 7 mm, unresponsive to standard treatment
Exclusion Criteria:
- Sickle Cell disease
- Renal insufficiency
- Upper respiratory ... | Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF | NCT01202643 | Contradiction |
4,428 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Male or female
- 18-65 years of age, inclusive
- Diagnosis of tendinitis in the elbow (lateral or medial epicondyle), Achilles tendon,
or patellar tendon based on examination of medical history and confirmed by physical
examination incl... | Long Duration Therapeutic Ultrasound for Tendon Healing | NCT02466308 | Contradiction |
1,109 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
1. Control group: (1) Absence of known systemic diseases; (2)Normal examinations（normal
findings in both echocardiography and CMR）.
2. Hypertrophic cardiomyopathy: 1) genetic determination of a pathogenic mutation or 2)
left ventricular hypertrophy (LV... | Differentiating Hypertrophic Cardiomyopathy From Hypertensive Heart Disease | NCT03271385 | Entailment |
3,635 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- ED patients >18 years old
- Seen in ED triage
Exclusion Criteria:
- patients <18 years old
- not seen in ED triage
- Adults unable to consent
- Prisoners
No condition on gender to be admitted to the trial.
No healthy ... | Emergency Department Safety Assessment and Follow-up Evaluation 2 | NCT02453243 | Entailment |
1,876 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Histologically documented adenocarcinoma of the stomach or Gastroesophageal Junction
(GEJ).
2. Age >18 years;
3. Eastern Cooperative Oncology Group (ECOG) Performance Status 0-1;
4. Chemotherapy: No prior chemotherapy is permitted for metas... | Docetaxel, 5-Fluorouracil and Oxaliplatin in Adenocarcinoma of the Stomach or Gastroesophageal Junction Patients | NCT00526110 | Entailment |
293 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Female subjects undergoing stimulation with Pergoveris for the ovarian stimulation
with VZO or with IUI or in preparation for a technology of the assisted conception
such as IVF or ICSI
Exclusion Criteria:
- Subjects receiving combination ... | A Non-interventional Study to Identify the Patients With Severe Luteinizing Hormone Deficiency in the Daily Practice | NCT01112618 | Contradiction |
4,873 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Patient with clinical and laboratory suspicions of hypersecretion of adrenal cortical
hormones
Exclusion Criteria:
- n/a
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Adrenal Scans With Radioiodine-Labeled Norcholesterol (NP-59) | NCT00591643 | Entailment |
5,591 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | INCLUSION CRITERIA:
Girls and women with TS diagnosed by karyotype or other genetic evidence of X-chromosome
defects and ovarian failure (diagnosed by failure to enter puberty spontaneously by age 18
or 2nd degree amenorrhea greater than 6 months and FSH greater than 40 mIU/ml)
Subject... | Hormone Replacement Therapy to Treat Turner Syndrome | NCT00013546 | Contradiction |
3,125 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com
Inclusion Criteria:
- Healthy subjects as determined by no clinically significant deviation from normal
medical history, physical examination, ECGs and clinical laboratory dete... | Placebo-Controlled, Single and Multiple Ascending Subcutaneous Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986089 in Healthy Adult Subjects | NCT02145234 | Contradiction |
390 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- first cycle of IVF with transfer of fresh embryo
Exclusion Criteria:
- use of non-autologous oocytes; prior diagnosis of premature ovarian failure or
diminished ovarian reserve; BMI>= 40; cryopreservation cycles; smokers; use of
PGS/PGD; u... | AMH and Dosing Regimens for Initial IVF Stimulation Protocols | NCT03098199 | Contradiction |
6,715 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
1. Male subjects ≥12 years to ≤65 years with a diagnosis of congenital moderate or severe
hemophilia A (FVIII:C ≤5%).
2. Documented history of at least 50 exposure days (EDs) to FVIII-containing products.
3. Evidence of a personally signed and dated info... | Moroctocog Alfa (AF-CC) for Prophylaxis and Treatment of Bleeding Episodes in Previously Treated Hemophilia A Patients | NCT04396639 | Contradiction |
1,673 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- age > 18 years
- native Italian speakers
- wrist/hand pathology
- trauma (fractures, tendon injuries, etc.)
- chronic pathology, the pathology has been present for at least 1 month (tenosynovitis,
chronic arthrosis pain, rheu... | Italian Translation of the Michigan Hand Outcomes Questionnaire | NCT04527588 | Entailment |
1,376 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Diarrhea
- constipation
Exclusion Criteria:
- Shock
- Sepsis
- Past history with GI tract surgery
- Immunodeficiency
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at le... | Effect of Probiotics on Intestinal Bacterial Population and Immune Modulation | NCT00763399 | Contradiction |
585 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Crown rump length (CRL) is appropriate to less than 12 weeks.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years | Early Pregnancy Failure: Factors Affecting Successful Medical Termination Treatment | NCT00782860 | Entailment |
3,727 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Adults over 50
- Patients undergoing outpatient treatment in orthopedic surgery for osteoarthritis of
the knee joint
- Patients diagnosed with Kellgren-Lawrence grade II or III osteoarthritis of the knee
by imaging examination
... | Effectiveness and Safety of Celecoxib (Celebrex 200 mg) Combined With Joins in the Treatment of Degenerative Knee Osteoarthritis: a Randomized Controlled Trial | NCT04718649 | Contradiction |
6,736 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Males, ≥12 years of age
- Severe hemophilia A or B with inhibitors
- (Severity confirmed by a central laboratory where FVIII level is <1% or FIX level
is ≤2% at Screening; Inhibitors defined as inhibitor titer of ≥0.6 BU/mL or as
... | A Study of Fitusiran (ALN-AT3SC) in Severe Hemophilia A and B Patients With Inhibitors | NCT03417102 | Contradiction |
2,960 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Patients classified as having clinically definite, clinically probable, or clinically
probable (laboratory-supported) ALS according to the El-Escorial diagnostic criteria
for ALS
2. Evidence of decremental response greater or equal to 5.0% in at lea... | A Registry-Based Clinical Trial of Pimozide in Patients With Neuromuscular Junction Transmission Dysfunction Due to ALS | NCT02463825 | Entailment |
322 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- IVF-ET candidates (excluding PGD and oocyte donor);
- Body mass index from 18 to 30 kg/m2;
- Non smokers;
- Regular menstrual cycles (25-35 days);
- Presence of both ovaries;
- Antral follicle count (follicles measuring from 3... | NATural Ovarian Stimulation | NCT02892942 | Contradiction |
1,492 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Have a history of swallowing difficulties associated with aging and/or previous or
current diagnosis of, but not limited to head and neck cancer (treatment may include
surgery, radiation or chemotherapy, or a combination of more than one), stroke,
... | Validation of a Revised Version of the Danish McGill Ingestive Skills Assessment | NCT02328196 | Entailment |
276 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- only single blastocyst transfer cycles were included
Exclusion Criteria:
- PGT-a cycles and cleavage stage embryo transfers
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years | Natural Cycles With Spontaneous Versus Induced Ovulation in FET | NCT03581422 | Contradiction |
1,277 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
1. the estimated amount of effusion is above 500 ml;
2. Drainage was not performed within 1 month before admission;
3. assigned informed consent.
Exclusion Criteria:
1. physical weakness which is difficult to withstand the thoracentesis;
... | Impact of Large-Volume Pleural Effusions on Heart Function | NCT02548221 | Entailment |
1,539 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Females 14-21 years old Note: Our pilot data are reassuring in that young women 18-25
years old with hypothalamic amenorrhea are not adversely affected with estrogen use.
In fact, in our prospective study, beneficial effects were observed both in young
... | Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes | NCT00946192 | Contradiction |
3,597 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Women in the fertile age (between 20-45 years), not assuming oral contraceptives from
at least three months
- Referred normal menses .Use of the same brand of sanitary protection wear for the
whole of the period.
- BMI between 18 and 30... | Protocol for the Determination of Menstrual Losses in Healthy Women With Apparently Normal Cycles | NCT01276964 | Contradiction |
3,780 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Males or females at the age of 40-75 years old
2. Conforming to the diagnosis standard of the American College of Rheumatology in 2009：
knee pain and osteophyte determined with X-ray, and at least one of the following
items：
- above... | Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) | NCT02323451 | Entailment |
219 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion criteria:
- Have a diagnosis of primary or secondary hypogonadism.
- Have very low testosterone levels on 2 separate days.
- Have a BMI within range of 18.5-35kg/m2.
- Have not taken dutasteride for one year, or finasteride for the past 3 months.
Exclus... | 28-Day Study of Testosterone Co-administered With Dutasteride in Hypogonadal Men | NCT00398580 | Entailment |
896 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
Staff from the Ziv Medical Center and patients
Exclusion Criteria:
Staff members that do not deal with pain treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be ... | Quality of Pain Management at the Ziv Medical Center | NCT02001454 | Entailment |
796 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Males or Females 40 years and older
2. According to the clinical diagnosis standard of the American College of Rheumatology
(ACR), someone, diagnosed as a single/both sides of osteoarthritis, who corresponds to
over 3 conditions of followings.
... | Clinical Trial of YYD302 for Treatment of Osteoarthritis of the Knee | NCT02965495 | Entailment |
2,485 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | - INCLUSION CRITERIA:
Participants will be eligible if they:
- Are 12 years of age or older.
- Have the ability to cooperate with an eye exam and adaptive optics imaging.
- Have the ability to understand and sign an informed consent or have a parent/legal
guard... | Adaptive Optics Retinal Imaging | NCT02317328 | Entailment |
3,861 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Knee pain on most days
- Either isolated patellofemoral osteoarthritis or mixed patellofemoral and tibiofemoral
osteoarthritis, as based on x-ray
Exclusion Criteria:
- Bed- or chair-bound, usually uses an ambulation aid to walk (e.g., cane,... | Knee Bracing for People With Patellofemoral Osteoarthritis | NCT00381563 | Entailment |
4,827 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- patients who have been cured of Cushing's disease at least 5 years ago.
Exclusion Criteria:
- patients who have been cured of Cushing's disease more than 15 years ago.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Sub... | Long-term Cardiovascular Risk in Cured Cushing's Patients | NCT00881283 | Contradiction |
3,850 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Symptomatic osteoarthritis of the knee.
Exclusion Criteria:
- No disorders which could interfere with study required assessments.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years o... | Safety and Effectiveness Study of a Non-Crosslinked HA Alkylamide HYADD(TM) 4 Hydrogel for Osteoarthritis of the Knee | NCT02187549 | Entailment |
3,636 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Age 18 years or older and receiving treatment in the ED
Exclusion Criteria:
- sustained altered mental status (e.g., psychosis, delirium, disorientation,
unresponsive)
- hostile or agitated behavior
- sexual assault victims
... | Dynamic Assessment and Referral System - Evaluation | NCT01153373 | Entailment |
2,798 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Patients of both genders aging between 18-65 years with primary unilateral
uncomplicated inguinal hernia were included.
Exclusion Criteria:
- Patients with bilateral or sliding inguinal hernia.
- incarcerated or strangulated hernia
... | Sutured Versus Cyanoacrylate Glue Mesh Fixation for Inguinal Hernia Repair | NCT04203940 | Entailment |
2,948 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Amyotrophic lateral sclerosis patients.
- Clinically stable, at least for one month.
Exclusion Criteria:
- Claustrophobic patients.
- Patients using continuous non-invasive ventilation treatment.
- Incapacity to tolerate supine d... | Relationship Between Respiratory Functional Tests and Image Thoracic Techniques in Patients With Neuromuscular Diseases | NCT01090674 | Entailment |
5,392 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Women patient aged 30-45 years
- Diagnosed adenomyosis by transvaginal ultrasound or MRI or 3D ultrasound
- Patient complains of heavy menstrual bleeding or dysmenorrhea or both
- Living in a nearby area to make follow-up reasonably possible
... | Levonorgestrel-releasing Intrauterine System Versus a Low-dose Combined Oral Contraceptive for Management of Adenomyosis Uteri | NCT03037944 | Entailment |
3,735 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Knee osteoarthritis
- Moderate radiographic evidence by Kellgren and Lawrence grade 2-4
- Knee pain > 20 on VAS pain scale
Exclusion Criteria:
- Bilateral knee replacements
- Unwillingness to take acetaminophen for pain relief
No... | Toward Better Outcomes in Osteoarthritis | NCT00000425 | Contradiction |
5,514 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Patients with newly onset or relapsed GCA
- > 50 years of age
- satisfying ACR criteria
- elevated sedimentation rate above 40 mm
- CRP > 20 mg/L
- Patients with histologically proven GCA or with large vessel vasculitis assess... | Tocilizumab for Patients With Giant Cell Arteritis | NCT01450137 | Entailment |
1,839 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Diagnosed with gastric cancer (histological or cytological) Attending health centers
of the Red UC Christus network for at least 3 months with clinical follow-up.
Capable to read and speak spanish Willing and able to provide written informed consent to
eh ... | Chilean Gastric Cancer Task Force (FORCE 1) | NCT03158571 | Entailment |
2,955 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Males or females age 21-65 years;
- No history of serious neurological injury or disease; OR
- Chronic (>12 months since injury) incomplete SCI between levels C2-C8 or diagnosis of
definite or probable ALS;
- Incomplete weakness of left ... | Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALS | NCT02469675 | Entailment |
1,356 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Hard or firm stools for twice or less per week
- Age were from newborn to 3 months
- Histochemical acetylcholinesterase reaction (AChE) in rectal mucosa was positive
- The narrowed distal bowel on barium enema was characterized as normal or short-seg... | A Trial on Conservative Treatment for Infants' Hirschsprung Disease | NCT01985646 | Contradiction |
2,247 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion criteria:
- Compliance and completion of the canakinumab PFS core study
- Unchanged significant clinical medical history from entry into core study
Exclusion criteria:
- Physician judgment of unsuitability for the study
- Pregnant or nursing women Other... | Long-Term Safety and Tolerability of Canakinumab Prefilled Syringes in Frequently Flaring Acute Gouty Arthritis Patients | NCT01431638 | Entailment |
4,924 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Diagnosed with Parkinson's Disease (ICD-10-GM G20.-) or Essential Tremor (G25.0)
- Comparison group: Other movement disorders including atypical Parkinsonian disorders
and healthy participants
Exclusion Criteria:
- Unable to obtain informed... | Utilizing Smart Devices to Identify New Phenotypical Characteristics in Movement Disorders | NCT03638479 | Entailment |
4,218 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- men with idiopathic infertility or unexplained
Exclusion Criteria:
- history of varicocele, genitourinary inflammation or infection
- history of cigarette smoking.
Male
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at... | Reduction of Sperm DNA Fragmentation by Oral Ginger | NCT02032251 | Contradiction |
3,819 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Age 18 to 65 years
2. Body mass index (BMI) ≤33 kg/m2
3. Grade 2And above imaging of osteoarthritis
4. History of knee pain or swelling should have at least 4 months
Exclusion Criteria:
1. treated with steroids and Anti-coagulant or ... | The Effect of Platelet-rich Plasma in Patients With Osteoarthritis of the Knee | NCT01926327 | Entailment |
1,402 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Subjects with written informed consent to participate in the study
Exclusion Criteria:
- Subjects with an apparent swallowing disorder
- Subjects with clinically evident cerebrovascular diseases
No condition on gender to be admitted to the trial.
Accept... | Visual and Auditory Breathing-swallowing Coordinated Training | NCT04590391 | Contradiction |
2,905 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | For the patients :
Inclusion Criteria:
- Man or woman with sporadic ALS and a possible, probable or definite diagnosis
regarding the revised Escorial criteria (Forbes et al., 2001). Patients are followed
quarterly according to national recommendations. At the end of the fo... | T Cell Phenotypes in Amyotropic Lateral Sclerosis (ALS), Influence of Vitamin D | NCT02756104 | Entailment |
6,991 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
1. Signed an Institutional Review Board (IRB) approved informed consent document
2. Aged 50 - 89 years inclusive.
3. Meeting the diagnosis of probable AD consistent with:
- Revised National Institute on Aging-Alzheimer's Disease Association (NIA-ADA)... | A Dose Titration Study of CPC-201 in Patients With Dementia of Alzheimer's Type | NCT02549196 | Entailment |
3,178 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Diagnosis of moderate to severe dry eye syndrome with or without Sjogren's syndrome or
other autoimmune disease
Exclusion Criteria:
- Intraocular or refractive surgery in the study eye within 3 months prior to study
start
- Unw... | Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-007) | NCT00548301 | Entailment |
1,658 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- I1. Sufficiently conversant in the English language to satisfy I3.
- I2. Able and willing to comply with all study requirements.
- I3. Able and willing to provide written informed consent to participate (including by
parent or legal guardian if unde... | Vital Sign Comparison Between Lifelight and Standard of Care - Development | NCT04003662 | Entailment |
4,150 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Between 20 and 75 years of age inclusive, at the time of signing the informed consent.
- Healthy as determined by the investigator or medically qualified designee based on a
medical evaluation including medical history, physical examination, laboratory tests
... | Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GSK2269557 Administered Via the ELLIPTA Dry Powder Inhaler to Healthy Subjects | NCT02691325 | Contradiction |
200 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. Secondary hypogonadal males between the ages of 18 and 65
2. Men currently using topical testosterone products should wash-out for at least 7 days
before Visit 1.
3. All clinical laboratory tests within normal ranges (any clinically significant
... | Safety Study of Enclomiphene Citrate in the Treatment of Men With Secondary Hypogonadism | NCT01534208 | Entailment |
5,510 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Diagnosis of GCA or TAK (defined below)
- History of active GCA or TAK within the past 2 months
- Age of 15 years or older
- Willing to use an effective means of birth control throughout the study
Specific Inclusion Criteria for Participants... | Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritis | NCT00556439 | Entailment |
2,131 | 13 | A 24-year-old man comes to the office complaining of infertility. He and his wife have been trying to conceive for the last 18 months. Medical records of his wife showed no abnormalities. The patient doesn't smoke and takes no medications. Height is 185 cm and weight is 77 kg. Heart and lung sounds are normal. Th... | I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was norm... | Inclusion Criteria:
- Signed informed consent/assent (as per local requirements), males aged 11-18 yrs.
(after his 10th and prior to 19th birthday), gynecomastia, one breast measuring ≥ 2 cm
in diameter (by ultrasound or caliper measurement) that has not decreased during the
... | Open Label Arimidex in Gynecomastia | NCT00241436 | Entailment |
1,321 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- Boys and girls.
- Aged 3 to 18 years old.
- Subjects with a Sensenbrenner's syndrome diagnosis and followed from 2005
- Parents/ legal guardian must provide non opposition prior to participation in the
study
Exclusion Criteria:
... | Sensenbrenner Clinical Study | NCT04184531 | Contradiction |
6,109 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Subject Inclusion Criteria:
An individual must meet the criteria below to be eligible.
- Individual is attending or invited to visit a participating collection site.
- Individual is 18 years or older at the time of consent.
- Individual is feeling well at the time of consent... | Evaluation of the COVIDSeq Test in Nasal Swab and Saliva From a COVID-19 Asymptomatic Population | NCT04561102 | Contradiction |
6,709 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Males, age 18 to 65 years.
- Subjects with Severe Hemophilia A with a documented plasma FVIII level of < 1%
- ≥ 150 exposure days with FVIII concentrate(s) as supported by medical records
Exclusion Criteria:
- Evidence of current or past inh... | BAY94-9027 PK Study Comparing to Another Long Acting Product | NCT03364998 | Contradiction |
3,964 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Individual will be included if they:
1. Have physician-diagnosed mild to moderate knee OA (OARSI atlas grades 1-2) based on
fixed-flexion x-ray radiological findings for osteophytes and joint space narrowing
within the past 12 months,
2. are between 35-65 years of age
... | Wearable Therapeutic Ultrasound Study for Knee Osteoarthritis | NCT01993693 | Entailment |
4,818 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion criteria:
- Male and female patients at least 18 years old
- Patients with confirmed pituitary origin of excess adrenocorticotropic hormone (ACTH)
production:
- Persistent hypercortisolemia established by two consecutive 24 h UFC levels at
... | Multicenter Study of Seliciclib (R-roscovitine) for Cushing Disease | NCT03774446 | Contradiction |
4,951 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Diagnosis of ET, as decided by the movement disorder specialist; Substantial
incapacity; Duration of symptoms > 5 years; Age 18 - 75; unsatisfying effect from
β-blockers, or be unable to tolerate the medical therapy.
Exclusion Criteria:
- ... | The Swedish Essential Tremor (SWEET) Trial | NCT03832712 | Entailment |
6,616 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- BMI between ≥18 kg/m² and <30 kg/m² at time of screening
- Body weight between ≥45 kg and <100 kg
- Baseline vWF:Ag between ≥60% and <170% (0.6-1.7 IU/mL)
Exclusion Criteria:
- History of and/or any sign or symptom indicating current abnorma... | Caplacizumab Single and Multiple Dose Study in Healthy Japanese and White Subjects. | NCT03172208 | Contradiction |
3,917 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- symptomatic and radiographic knee OA
Exclusion Criteria:
- severe patella femoral knee pain that would make cycling difficult
- medical condition which would prohibit an exercise program
No condition on gender to be admitted to the trial.
No healthy sub... | The Effects of Group Cycling (Spinning®) With Knee Osteoarthritis: A Randomized Control Trial | NCT00917618 | Entailment |
5,908 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Age 20 and over (at the time of consent given)
- Gender and inpatient or outpatient: Irrelevant
- Patients diagnosed with Grade A or Grade B mild reflux oesophagitis (according to the
Los Angels classification) through endoscopic test
- ... | Verification Study on Lafutidine in Mild Reflux Oesophagitis - Double Blind Controlled Study With Famotidine - | NCT00229424 | Contradiction |
1,774 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Consecutive patients aged 18-65 years who go to the gastroenterology clinic presented
with upper gastrointestinal discomfort, such as heartburn, regurgitation, dysphagia,
substernal pain, epigastric pain, epigastric burning, early satiety, postprandial
... | The Primary Symptoms of GERD(Gastroesophageal Reflux Disease) in Chinese Outpatients in Gastroenterology Department | NCT02506634 | Contradiction |
5,038 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- diagnosis of essential tremor made according to the newest consensus statement on the
classification of tremors
- patients initiated on propranolol or primidone
Exclusion Criteria:
- a history of seizures
- a history of mental i... | Pathophysiology of Tremor-modulating Mechanisms of Propranolol and Primidone in Essential Tremor | NCT04692844 | Entailment |
4,707 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- women with adenomyosis
- at early- to mid-secretory phases
Exclusion Criteria:
- postmenopausal
- malignancy
Female
Accepts Healthy Volunteers
Subject must be at least 35 Years old.
Subject must be at most 50 Years | Progestin Treatment for Endometrial Stromal Cells in Adenomyosis | NCT00155051 | Entailment |
5,040 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
Parkinson's disease
- Male or female with age over 40 years
- Clinical diagnosis of Parkinson's disease
- Ability to give informed consent
Essential tremor
- Male or female with age over 40 years
- Clinical diagnosis of Es... | Efficacy and Safety of F-18 FPCIT PET in Parkinson's Disease and Essential Tremor Patients | NCT00468078 | Entailment |
4,174 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Non-smoking, healthy male or female, age greater than or equal to (>=) 18 years and
<55 years old at the time of informed consent. To be considered non-smokers,
Participants must have discontinued smoking for at least 4 weeks before dosing
2. Japane... | A Study to Assess the Safety and Tolerability of E2730 After Multiple Dose and the Food Effect After Single Dose in Healthy Participants | NCT04676685 | Contradiction |
6,503 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. Male or female subjects age 18 or older.
2. Diagnosis of moderate to severe papulopustular rosacea with IGA of 3- moderate or
4-severe.
3. Presence of 12 - 50 inflammatory lesions and persistent erythema with or without
telangiectasia.
... | Azelaic Acid Foam 15% in the Treatment of Papulopustular Rosacea | NCT03418610 | Entailment |
45 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. Agrees to written as well as audio-visual informed consent.
2. Ability to understand the risks/benefits of the protocol
3. Male between 35-65 years of age.
4. Diagnosed with Symptomatic hypogonadism
Exclusion Criteria:
1. Uncooperati... | The Efficacy Study of FUROSAP: A Testosterone Booster Supplement In Humans. | NCT02702882 | Contradiction |
3,306 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Patients have been recruited into the study by referral from an ophthalmologist or
pediatrician.
Entrance into the study was dependent upon clinical evidence of decreased or absent
pigmentation in skin, hair, and/or eyes.
The definition was purposefully broad to include the broad range... | Visual Function and Ocular Pigmentation in Albinism | NCT00001153 | Entailment |
5,399 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Subject has voluntarily given written informed consent (before conduct of any
study-related procedures)
- The subject has hereditary type 3 VWD (<= 3 IU/dL VWF:Ag)or severe type 1 or type 2A
VWD (VWF:RCo <= 10% and FVIII:C <20%)
- The s... | Pharmacokinetic, Safety and Tolerability Study of Recombinant Von Willebrand Factor / Recombinant Factor VIII Complex in Type 3 Von Willebrand Disease | NCT00816660 | Entailment |
1,586 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Right-handed (assessed by Edinburgh Handedness Inventory)
- Healthy volunteers (self report)
- Absence of neurological and psychiatric diseases
- No history of severe musculoskeletal injury to wrists and fingers
- Without using drugs or n... | Non-invasive Cerebellar Stimulation on Motor Learning | NCT02559518 | Contradiction |
4,442 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- The diagnoses included are lateral elbow pain, lateral epicondylitis, or lateral
epicondylalgia, more general diagnoses elbow tendinitis or elbow pain will be included
if their clinical picture at physical therapy meets criteria for lateral
epicon... | Trial of Blood Flow Restriction Plus Physical Therapy vs. Physical Therapy Alone for Lateral Epicondylitis | NCT03978897 | Contradiction |
1,811 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Subject older than 18 years and younger than 80 years
- Subject referred for upper gastro-intestinal endoscopy under general anesthesia for
anemia, intestinal metaplasia in the stomach, Helicobacter pylori screening, or
submucosal dissection
... | Normal Values for Esophageal and Pyloric Impedance Planimetry Under General Anesthesia (NormaFLIP) | NCT02905669 | Contradiction |
3,889 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. The patient provides consent to be part of the research.
2. The diagnosis of Knee Osteoarthritis was made based on clinical criteria/radiology
American College of Rheumatology (ACR) 2012 with radiology grading according to
Kellgren-Lawrence 2-3
... | Prolotherapy Intervention Effect in Patient With Knee Osteoarthritis | NCT04557943 | Entailment |
5,400 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Women and girls with an active diagnosis of a congenital bleeding disorder (as
designated by the institution inputting data);
1. Deficiencies of factors VIII, IX, II, V, VII, VII, IX, X, XI, FV+VIII, XIII,
Plasminogen Activator Inhibitor 1... | Characterizing the Impact and Treatment of Reproductive Tract Bleeding on Women and Post-menarchal Girls With Bleeding Disorders | NCT03834727 | Entailment |
6,849 | 49 | A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating. She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems ... | I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not un... | Inclusion Criteria:
- Woman or man> 18 years,
- Signature of informed consent,
- Muscle biopsy for suspicion of recent inflammatory myopathy (<6 months) or for
exclusion of neuromuscular pathology.
Prospectively, following the results of the muscle biopsy, the s... | Exercise Capacity of Patients With Dermatomyosis | NCT03293615 | Entailment |
6,575 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Body weight >/= 40 kilograms (kg) at the time of screening
- Diagnosis of congenital hemophilia A of any severity and documented history of
high-titer inhibitor ( that is [i.e.], >/= 5 Bethesda Units [BU])
- Documentation of treatment with episodic ... | A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants With Inhibitors | NCT02622321 | Contradiction |
3,820 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Adult male and female in-patients with vital signs considered 'stable' by clinical
caregivers.
Exclusion Criteria:
- Pediatric patients
- Female patients who are pregnant
- Patients with internal or external defibrillators
... | Vital Signs Patch Early Feasibility and Usability Study v1.0 | NCT02524470 | Entailment |
953 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Male or Female patients between the ages of 40-75 with a diagnosis of Osteoarthritis
of the knee consistent with the ACR Clinical Classification Criteria for Arthritis of
the Knee (Altman, R. et al., 1991):
- Current knee pain,
... | A Comparison of the Analgesic Efficacy and Safety of Once Daily Tramadol OAD Tablets to Twice Daily Tramadol BID for the Treatment of Osteoarthritis of the Knee (Extension Protocol) and Open Label Safety Follow-Up | NCT00912015 | Entailment |
5,604 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- 8-10 years old
- healthy
- African American
- parent willing to participate in data collection
- internet access
- personal email address
Exclusion Criteria:
- mental, physical, or medical conditions that ... | Food, Fun, & Fitness Internet Program for Girls: Outcome Evaluation | NCT01481948 | Contradiction |
4,203 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Men with normospermia who are initiating testosterone replacement and are over 18
years of age will provide semen samples to NYU Fertility Center.
Exclusion Criteria:
- Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artifici... | Quantitative MRI for Functional Imaging of the Testis: A New Methodology for Evaluation of the Infertile Male | NCT02756325 | Contradiction |
4,506 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Female of Chinese origin, with two ethnic Chinese parents and four ethnic Chinese
grandparents 21-40 years of age (both inclusive)
- Willing to stop using combined oral contraceptives (COC) in relation to the first
DECAPEPTYL Depot administration o... | Rekovelle PK Trial in Chinese Women | NCT04150861 | Contradiction |
6,971 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- adult patients, 50-90 years of age;
- diagnosis of probable Alzheimer Disease, with symptoms >=1 year prior to screening;
- meets DSM-IV criteria for Alzheimer-type dementia;
- stabilised on approved medications for treatment of Alzheimer Disease for... | A Multiple Ascending Dose Study of R1450 in Patients With Alzheimer Disease. | NCT00531804 | Entailment |
6,950 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
Diagnosed Alzheimer´s disease
Exclusion Criteria:
Other neurological comorbidity, substance abuse
No condition on gender to be admitted to the trial.
| Processing of Music in Alzheimer Patients | NCT04132193 | Entailment |
2,858 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Able to understand and give written informed consent.
2. Male or female patients aged 35 years or greater (inclusive) and less than 75 years of
age at the time of ALS diagnosis.
3. Patients with a confirmed ALS diagnosis: "definite ALS" or "probable A... | 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis (REPAIR-ALS) | NCT03843710 | Entailment |
2,972 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Subjects will be individuals with neurologic or neuromuscular disease who are deemed
well-enough for sample collection.
Exclusion Criteria:
- Subjects who are not willing to undergo sample collection, genetic analysis, or
unwilling to shar... | Genetic and Blood Biomarkers in Neurological and Neuromuscular Diseases | NCT02780531 | Entailment |
2,833 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- diagnosis of probable, laboratory-supported probable, or definite amyotrophic lateral
sclerosis according to the El Escorial revised criteria
- spinal onset
- aged 18 to 85 years inclusive
- disease duration ≤ 24 months
- dis... | Transcranial Direct Current Stimulation as a Novel Therapeutic Approach in Amyotrophic Lateral Sclerosis | NCT01569958 | Entailment |
6,470 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. Subjects must be able to understand the requirements of the study and be willing to
give written informed consent.
2. Male and female subjects aged 18 years and above.
3. Subjects, any gender or ethnicity (and of Fitzpatrick skin type I - III), must b... | A Controlled Study to Assess the Efficacy, Safety and Tolerability of Oral DFD-29 Extended Release Capsules | NCT03340961 | Entailment |
5,979 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion criteria:
A. Males and females of age 18-55. B. A diagnosis of epigastric pain/discomfort (located in
the upper abdomen) rated by the patient as moderate to severe in intensity (on a four-point
categorical scale), which has been present at least 3 times per week for 12 weeks,
... | Inhibition of Gastric Acid is the Key to Satisfactory Relief of Symptoms With Esomeprazole in NUD Patients | NCT00222131 | Entailment |
4,954 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Diagnosis of refractory essential tremor scheduled for unilateral thalamic deep brain
stimulator placement
- Age ≥ 18 years
Exclusion Criteria:
- Prior deep brain stimulator, stereotactic radiosurgery, or focused ultrasound
pro... | Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor | NCT03875404 | Entailment |
6,434 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. Provide IRB approved written informed consent/assent.
2. Male or non-pregnant female, ≥ 18 years of age.
3. Diagnosis of rosacea with moderate to severe erythema on the face defined as: a score
of ≥ 3 on the Clinician's Erythema Assessment (CEA) and a... | Comparative Safety and Efficacy of Two Rosacea Products in the Treatment of Facial Erythema of Rosacea | NCT02385240 | Entailment |
6,542 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria
1. Participant is < 6 years old at the time of screening
2. Participant is previously untreated with < 3 exposure days (EDs) to ADVATE, BAX 855 or
plasma transfusion at any time prior to screening
3. Participant has severe hemophilia A (Factor VIII (FVIII... | Safety, Immunogenicity and Hemostatic Efficacy of PEGylated Recombinant FVIII (BAX 855) in Previously Untreated Patients (PUPs) < 6 Years of Age With Severe Hemophilia A | NCT02615691 | Contradiction |
67 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Age greater than or equal to 50 years but not older than 80 years of age;
- Serum testosterone level <13.8 nmol/l;
- Sperm concentration > 40 Million/ml;
- Willing to give written informed consent.
Exclusion Criteria:
- Testicula... | Influence of Administration Route of Testosterone on Male Fertility | NCT00705796 | Contradiction |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.