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ff5bd45 | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 | {
"allow_unverified_wt_in_exploratory_analysis": true,
"alpha": 0.05,
"batch_A_genes": 24,
"conditional_estimand": "E[CRISPR X | A=1,B=1] - E[CRISPR X | A=1,B=0]",
"download_optional_omics": true,
"drug_estimand": "E[PRISM AUC | A=1,B=1] - E[PRISM AUC | A=1,B=0]",
"expected_crispr_sigma": 0.45,
"figshare_article_id": 27993248,
"figshare_version": 1,
"genotypes_require_both_matrices": true,
"gsea_max_size": 300,
"gsea_min_size": 10,
"holdout_fraction": 0.2,
"interaction_auxiliary": "A*B non-additive association, not necessary for conditional estimand",
"max_condition_number": 1000000000.0,
"min_enrichment_genes": 5,
"min_gene_observations": 12,
"min_overlap_per_lineage_arm": 2,
"min_per_arm_estimable": 5,
"min_per_arm_for_four_group": 5,
"min_reporting_effect_gene": 1,
"min_residual_df": 8,
"multiplicity": "Original Simes pair BH / within BH / global gene-context BH, BY dependence sensitivity",
"mutation_call": "OR(damaging,hotspot); zero is no reported qualifying mutation, NOT verified WT",
"n_gsea_permutations": 250,
"pathway_for_discoveries_only": true,
"pinned_release": "DepMap 24Q4 Public v1 (machine-accessible verified release)",
"report_top_n": 20,
"researcher_review": "PENDING",
"root": "/kaggle/working/final_comutation_fresh_20261104_192636_UTC",
"run_four_group_interactions": true,
"run_live": true,
"run_pan_cancer": true,
"run_within_lineage": true,
"save_pair_chunk_rows": 500000,
"seed": 20261026,
"source_policy": "Only raw provider releases fetched in this run; never read previous result repositories",
"target_ci_halfwidth": 0.25,
"use_mutation_burden_covariate": true
} |