Datasets:
Add recurrence controls, numerical decomposition and updated vector article
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- .gitattributes +10 -0
- wu_20261107_recurrence_timing/METHODS_RESULTS_zh.md +56 -0
- wu_20261107_recurrence_timing/README.md +41 -0
- wu_20261107_recurrence_timing/archive_members.json +1332 -0
- wu_20261107_recurrence_timing/assets/mushroom_body.pdf +0 -0
- wu_20261107_recurrence_timing/assets/mushroom_body.svg +32 -0
- wu_20261107_recurrence_timing/assets/registered_brain.pdf +3 -0
- wu_20261107_recurrence_timing/assets/registered_brain.svg +0 -0
- wu_20261107_recurrence_timing/assets/synapse_circuit.pdf +0 -0
- wu_20261107_recurrence_timing/assets/synapse_circuit.svg +16 -0
- wu_20261107_recurrence_timing/briefing.pdf +3 -0
- wu_20261107_recurrence_timing/briefing.pptx +3 -0
- wu_20261107_recurrence_timing/dependencies.json +16 -0
- wu_20261107_recurrence_timing/figures/ExtendedData1.pdf +0 -0
- wu_20261107_recurrence_timing/figures/ExtendedData10.pdf +0 -0
- wu_20261107_recurrence_timing/figures/ExtendedData11.pdf +3 -0
- wu_20261107_recurrence_timing/figures/ExtendedData11.svg +0 -0
- wu_20261107_recurrence_timing/figures/ExtendedData12.pdf +0 -0
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- wu_20261107_recurrence_timing/figures/ExtendedData13.pdf +0 -0
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- wu_20261107_recurrence_timing/figures/ExtendedData14.pdf +0 -0
- wu_20261107_recurrence_timing/figures/ExtendedData14.svg +197 -0
- wu_20261107_recurrence_timing/figures/ExtendedData2.pdf +0 -0
- wu_20261107_recurrence_timing/figures/ExtendedData3.pdf +0 -0
- wu_20261107_recurrence_timing/figures/ExtendedData4.pdf +0 -0
- wu_20261107_recurrence_timing/figures/ExtendedData5.pdf +3 -0
- wu_20261107_recurrence_timing/figures/ExtendedData6.pdf +3 -0
- wu_20261107_recurrence_timing/figures/ExtendedData7.pdf +3 -0
- wu_20261107_recurrence_timing/figures/ExtendedData8.pdf +0 -0
- wu_20261107_recurrence_timing/figures/ExtendedData9.pdf +0 -0
- wu_20261107_recurrence_timing/figures/Figure1.pdf +3 -0
- wu_20261107_recurrence_timing/figures/Figure1.svg +0 -0
- wu_20261107_recurrence_timing/figures/Figure2.pdf +0 -0
- wu_20261107_recurrence_timing/figures/Figure2.svg +146 -0
- wu_20261107_recurrence_timing/figures/Figure3.pdf +0 -0
- wu_20261107_recurrence_timing/figures/Figure3.svg +428 -0
- wu_20261107_recurrence_timing/figures/Figure4.pdf +0 -0
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- wu_20261107_recurrence_timing/figures/Figure5.pdf +0 -0
- wu_20261107_recurrence_timing/figures/Figure5.svg +0 -0
- wu_20261107_recurrence_timing/figures/Figure6.pdf +0 -0
- wu_20261107_recurrence_timing/figures/Figure6.svg +160 -0
- wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/KC_response.csv +33 -0
- wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/KC_traces.npz +3 -0
- wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/MBON_post_location_registry.csv +145 -0
- wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/MBON_response.csv +3 -0
- wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/MBON_traces.npz +3 -0
- wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/STATUS.json +26 -0
- wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/actual_arrivals.csv +0 -0
.gitattributes
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wu_20261107_contact_asynchrony/figures/Figure1.pdf filter=lfs diff=lfs merge=lfs -text
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wu_20261107_contact_asynchrony/manuscript.pdf filter=lfs diff=lfs merge=lfs -text
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wu_20261107_contact_asynchrony/source_data/meshes/BRAIN.glb filter=lfs diff=lfs merge=lfs -text
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wu_20261107_contact_asynchrony/manuscript.pdf filter=lfs diff=lfs merge=lfs -text
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wu_20261107_contact_asynchrony/source_data/meshes/BRAIN.glb filter=lfs diff=lfs merge=lfs -text
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wu_20261107_recurrence_timing/assets/registered_brain.pdf filter=lfs diff=lfs merge=lfs -text
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wu_20261107_recurrence_timing/manuscript.pdf filter=lfs diff=lfs merge=lfs -text
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wu_20261107_recurrence_timing/METHODS_RESULTS_zh.md
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# 当前方法与结论:循环传递与接点时间协调
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本轮完成11次新计算:8个循环关闭条件,以及L输入的记录采样、时间步长、空间网格3个独立控制。对9个历史配对条件重新读取原始轨迹;合计核验640个细胞—条件读数,其中352个来自本轮计算。每个输入、静默行、潜伏期和原始波形均保留。
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## 方法
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沿用吴老师要求的真实树结构、突触三维落点、输入/输出方向与伙伴身份。结构底座保留5,177个KC;原始61细胞的32/15/14不改写,14细胞的精细功能问题继续保留。仿真使用原32个KC和2个真实被动MBON14,含1,926个KC循环接点、144个KC→MBON接点。按原三家族资格,10细胞接受平衡边界驱动,22细胞仍完整在线。
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外部参考电导固定E=1nS,每活跃接点18个事件。把共享同步/接点独立时序分别与R=0/1nS交叉,四种输入A、V、L、ABC均完整覆盖;独立时序严格复用前版首个冻结种子。R=0保留连接登记,但逐接点积分电导和电荷必须为零。源阈值事件、零权重到达记录与操作性起始部位波形分开审计。
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波形以峰值≥0mV、前2ms最大上升速率≥10mV/ms、最小峰间隔2ms识别,统计窗100≤t<1000ms;胞体均电位窗100≤t<1100ms。响应时间同时相对最早全局输入和本细胞最早局部输入保存;静默细胞保留零计数和空潜伏期。计数、覆盖、连续电位、首响应分别比较。
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## 本轮机制结果
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下表每项为“总波形数 / 响应细胞数”,覆盖原32细胞。
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|时间组织|循环R|A|V|L|ABC|
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|---|---:|---:|---:|---:|---:|
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|共享同步|0nS|18 / 1细胞|0 / 0细胞|0 / 0细胞|18 / 1细胞|
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|共享同步|1nS|559 / 32细胞|0 / 0细胞|0 / 0细胞|559 / 32细胞|
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|接点独立,种子09|0nS|5 / 1细胞|2 / 1细胞|2 / 1细胞|1 / 1细胞|
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|接点独立,种子09|1nS|252 / 32细胞|158 / 32细胞|188 / 32细胞|281 / 32细胞|
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完整逐细胞因果干预差见`recurrence_factorial.csv`。R=0的循环积分电导/电荷全部为零;不存在把零权重到达事件当作有效循环传递的情况。结果把直接驱动与循环募集分开,结论对应这里的模型参数、输入预算与时序。按响应重新划分生物学亚型不属于本轮估计。
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## L输入数值分解
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同一接点事件、相同电导与原32细胞,对记录采样、时间和空间独立控制。
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|配置|KC/MBON最大段长µm|dt ms|采样ms|波形数|响应细胞|
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|---|---:|---:|---:|---:|---:|
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|原始|0.25/0.5|0.0025|0.025|188|32|
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|仅提高采样|0.25/0.5|0.0025|0.0125|188|32|
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|仅细化时间|0.25/0.5|0.00125|0.0125|192|32|
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|仅细化空间|0.125/0.25|0.0025|0.0125|158|32|
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|时间/空间联合|0.125/0.25|0.00125|0.0125|125|32|
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`numerical_decomposition.csv`保留所有细胞的计数变化、首响应变化与胞体轨迹RMS。响应覆盖与累积计数分别呈现;细化差异直接写入结果,不用总数相近替代轨迹检验。前版首种子四输入联合细化仍保留:A/V/L/ABC=250/160/125/281,混合减逐细胞最强单输入的求和为+28。
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## 保留的证据链与文献
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三组接点独立时序在R=1nS均使V/L覆盖原32细胞;混合计数差分别+29、+25、−2。共享时序的抖动比较与接点独立时序区分;连续剖面95.4852%的第一共同模态只对应原共享同步面板。公开KC生理按7个Fly-ID留出:固定WT9与经验训练波形均值的平均误差分别35.216与32.723mV;按作者QC保留4个时为15.820与14.192mV。所有24个QC判定均能重建。
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新增核验2026年蜜蜂嗅觉—视觉MBON复合响应文献,DOI10.3389/fphys.2026.1898182。取得带CC BY许可的全文,作为跨物种讨论背景。该文只提供向作者索取数据的声明,全文未列出公开数据编号或代码仓库;本轮没有据此声称原始数据复分析。逐项证据见`new_literature_evidence.csv`,此前真实脑/蘑菇体矢量来源与组件许可继续保留。
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## 文章、图版与汇报
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[29页英文稿](exports/manuscript.pdf)、[文章源文件](manuscript/article.md)、[LaTeX](manuscript/main.tex)、[Overleaf包](https://huggingface.co/datasets/cyd0806/neuronmimic-data/resolve/main/wu_20261107_recurrence_timing/overleaf_submission.zip);六张复合主图25子图、十四张扩展图;[12页PPTX](https://huggingface.co/datasets/cyd0806/neuronmimic-data/resolve/main/wu_20261107_recurrence_timing/briefing.pptx)、[矢量汇报PDF](exports/吴老师汇报_循环与时间协调机制_20261107.pdf)。主图2改为循环关闭配对,扩展图13为独立数值分解,原主图2的非零增益比较保留为扩展图14。真实脑区矢量与真实骨架继续用作主图解剖锚点。
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## 执行与复现记录
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方案在计算前冻结。首5个条件保存完13个原始科学文件后,因状态序列化中的执行字段重复而退出1;独立重提取全部波形、核对数组与电荷后才补全状态和事件登记,原13文件的字节保持不变。修复说明、冻结哈希、原退出记录和恢复审计一并保留。缺失的原计时不补造;恢复状态用空计时。余下条件使用只过滤重复执行字段的修复入口,数值参数与模型均不变。
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代码沿用已授权GitHub分支;数据以`wu_20261107_recurrence_timing`新前缀增量发布,历史版本完整保留。确切提交、对象核验和历史保留数以`metadata/publication_receipt.json`为准。
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wu_20261107_recurrence_timing/README.md
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# Recurrent transmission and contact-level timing in a synapse-resolved mushroom body
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This successor completes **11 new numerical runs**: an eight-condition zero-recurrence timing/input panel and three independent L numerical controls. Nine original matched runs are re-audited, yielding 640 cell-condition readouts, including 352 new ones. The original32/15/14, real cable trees, contact identities, boundary event budgets and physiological parameters are preserved.
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- [29-page article](exports/manuscript.pdf), [manuscript source](manuscript/article.md), [LaTeX](manuscript/main.tex), [independently compiled Overleaf package](https://huggingface.co/datasets/cyd0806/neuronmimic-data/resolve/main/wu_20261107_recurrence_timing/overleaf_submission.zip).
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- [12-slide Chinese PPTX](https://huggingface.co/datasets/cyd0806/neuronmimic-data/resolve/main/wu_20261107_recurrence_timing/briefing.pptx), [vector briefing PDF](exports/吴老师汇报_循环与时间协调机制_20261107.pdf), [methods and findings in Chinese](当前方法与结论.md).
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- [Six composite vector main figures](figures/), [real brain/MB artwork](assets/registered_brain.svg), [canonical data](source_data/), [scientific audits](validation/), [publication identities](metadata/publication_receipt.json).
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## Results
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Each entry below gives operational waveform counts and responding cells out of32. E=1nS and each active boundary contact retains18 events. R0 preserves connection objects but carries exactly zero integrated recurrent conductance and charge.
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|时间组织|循环R|A|V|L|ABC|
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|---|---:|---:|---:|---:|---:|
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|共享同步|0nS|18 / 1细胞|0 / 0细胞|0 / 0细胞|18 / 1细胞|
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|共享同步|1nS|559 / 32细胞|0 / 0细胞|0 / 0细胞|559 / 32细胞|
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|接点独立,种子09|0nS|5 / 1细胞|2 / 1细胞|2 / 1细胞|1 / 1细胞|
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|接点独立,种子09|1nS|252 / 32细胞|158 / 32细胞|188 / 32细胞|281 / 32细胞|
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Figure2 now presents the matched schedule-by-recurrence intervention. Extended Data13 separates acquisition sampling, time-step and cable controls; Extended Data14 preserves the former nonzero conductance comparison. All six main figures/25 panels and fourteen Extended Data figures accompany the manuscript. The three-seed contact-timing results, source-attributed brain projections, structural nulls and public Fly-ID physiology remain explicit layers of the same evidence chain.
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## Reproduce
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See [REPRODUCIBILITY.md](REPRODUCIBILITY.md) for exact dependency revisions, raw-data restoration and the execution-only repair. No additional full second simulation repeat is claimed. Saved-data extraction and isolated compact figure reconstruction were executed.
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```bash
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python projects/wu_20261107_recurrence_timing/code/analyze_mechanism.py
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python projects/wu_20261107_recurrence_timing/code/build_figures.py
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python projects/wu_20261107_recurrence_timing/code/build_paper.py
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python projects/wu_20261107_recurrence_timing/code/build_slides.py
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python projects/wu_20261107_recurrence_timing/code/verify_release.py
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```
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| 35 |
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The11 complete new raw runs are directly available under HF `main/` and `fine/`. The compact `paper_and_vectors.tar.gz` archive includes editable figures, canonical sources, all manuscript files, source attribution and code. Restore the9 matched legacy runs at their original paths to re-extract the full20-condition audit. Their immutable predecessors and file-level hashes are in `metadata/dependencies.json` and `metadata/mechanism_raw_manifest.json`.
|
| 36 |
+
|
| 37 |
+
The primary protocol and original runner remain frozen. `execution_repair.json` documents a final-status serialization failure after the first5 complete raw payloads; their13 scientific files were audited and left byte-identical. The production rerun entry is `run_mechanism_repaired.py`. Original exit1 records and missing per-run timings are preserved explicitly; no timer is invented. The recovery utility is one-time provenance, not a normal rerun step.
|
| 38 |
+
|
| 39 |
+
## Publication and sources
|
| 40 |
+
|
| 41 |
+
GitHub: `ydchen0806/bio_fly_cyber_lateralization`, branch `research/wu-structure-function-20261104`. HF: `cyd0806/neuronmimic-data`, additive prefix `wu_20261107_recurrence_timing`. Historical prefixes are preserved. Source meshes retain their component-specific CC BY-NC4.0 notes and credits. The inspected honeybee MBON article (DOI10.3389/fphys.2026.1898182) is comparative context with CC BY full-text attribution, not a new raw-data validation; its data statement offers author-mediated access and states no public code repository. No journal artwork is copied.
|
wu_20261107_recurrence_timing/archive_members.json
ADDED
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wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/KC_traces.npz
ADDED
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version https://git-lfs.github.com/spec/v1
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size 65621041
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wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/MBON_post_location_registry.csv
ADDED
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|
wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/MBON_response.csv
ADDED
|
@@ -0,0 +1,3 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
+
gid,root_id,mean_soma_delta_mV,peak_soma_delta_mV,n_contacts
|
| 2 |
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32,720575940614026193,1.0657194565303476,3.846313906248348,119
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| 3 |
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33,720575940639697827,0.23850743695119303,0.7296368524089232,25
|
wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/MBON_traces.npz
ADDED
|
@@ -0,0 +1,3 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
+
version https://git-lfs.github.com/spec/v1
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| 2 |
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oid sha256:a69e43bbae5fc7e7689ee3a0456008d003e63e2f0d2ce91913e9d231228de555
|
| 3 |
+
size 28256793
|
wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/STATUS.json
ADDED
|
@@ -0,0 +1,26 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
|
|
|
| 1 |
+
{
|
| 2 |
+
"status": "COMPUTED_AUTONOMOUS_COMBINATION",
|
| 3 |
+
"condition": "async_R1_L_sample_control",
|
| 4 |
+
"panel": "balanced",
|
| 5 |
+
"mask": 4,
|
| 6 |
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"weight_uS": 0.001,
|
| 7 |
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"external_weight_uS": 0.001,
|
| 8 |
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"recurrent_weight_uS": 0.001,
|
| 9 |
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"event_schedule": "contact_independent_jitter",
|
| 10 |
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"seed": 20261109,
|
| 11 |
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"n_events": 18,
|
| 12 |
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"threads": 5,
|
| 13 |
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"initiation_sample_ms": 0.0125,
|
| 14 |
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"stage": "fine",
|
| 15 |
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"KCmesh_um": 0.25,
|
| 16 |
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"MBONmesh_um": 0.5,
|
| 17 |
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"dt_ms": 0.0025,
|
| 18 |
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"n_cv": 158568,
|
| 19 |
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"n_cells": 34,
|
| 20 |
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"n_KC_waveform_events": 188,
|
| 21 |
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"n_internal_arrivals": 11432,
|
| 22 |
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"n_MBON_arrivals": 863,
|
| 23 |
+
"gate": {},
|
| 24 |
+
"elapsed_s": 330.77532180026174,
|
| 25 |
+
"scope": "Online excitatory KC subnetwork with partial passive MBON output; synthetic inputs and unvalidated parameter/release transfers. No biological validation."
|
| 26 |
+
}
|
wu_20261107_recurrence_timing/fine/async_R1_L_sample_control/actual_arrivals.csv
ADDED
|
The diff for this file is too large to render.
See raw diff
|
|
|