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Release all 5177 KC classifications, full raw archives, class dictionary, article and 12-slide Wu briefing

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  16. wu_20261109_full_atlas_briefing/code/build_atlas_figures.py +93 -0
  17. wu_20261109_full_atlas_briefing/code/build_briefing.py +124 -0
  18. wu_20261109_full_atlas_briefing/code/build_paper.py +160 -0
  19. wu_20261109_full_atlas_briefing/code/build_reader_docs.py +103 -0
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  23. wu_20261109_full_atlas_briefing/code/package_raw.py +38 -0
  24. wu_20261109_full_atlas_briefing/code/publish_release.py +68 -0
  25. wu_20261109_full_atlas_briefing/code/query_class.py +20 -0
  26. wu_20261109_full_atlas_briefing/code/seal_handoff.py +34 -0
  27. wu_20261109_full_atlas_briefing/code/unpack_raw.py +19 -0
  28. wu_20261109_full_atlas_briefing/code/update_article.py +37 -0
  29. wu_20261109_full_atlas_briefing/data/KC5177_master.csv +0 -0
  30. wu_20261109_full_atlas_briefing/data/KC5177_master.parquet +3 -0
  31. wu_20261109_full_atlas_briefing/data/active_cells.csv +0 -0
  32. wu_20261109_full_atlas_briefing/data/active_pair_summary.csv +13 -0
  33. wu_20261109_full_atlas_briefing/data/all_class_memberships.csv +3 -0
  34. wu_20261109_full_atlas_briefing/data/all_class_memberships.parquet +3 -0
  35. wu_20261109_full_atlas_briefing/data/all_class_partner_fingerprints.parquet +3 -0
  36. wu_20261109_full_atlas_briefing/data/async_run_summary.csv +18 -0
  37. wu_20261109_full_atlas_briefing/data/cell_input_family_profiles.csv +0 -0
  38. wu_20261109_full_atlas_briefing/data/centroid_runs.csv +41 -0
  39. wu_20261109_full_atlas_briefing/data/class_dictionary.csv +0 -0
  40. wu_20261109_full_atlas_briefing/data/class_dictionary.parquet +3 -0
  41. wu_20261109_full_atlas_briefing/data/dispersion_runs.csv +41 -0
  42. wu_20261109_full_atlas_briefing/data/entry_roles_including_residuals.parquet +3 -0
  43. wu_20261109_full_atlas_briefing/data/finest20_source_summary.csv +21 -0
  44. wu_20261109_full_atlas_briefing/data/member_list_index.csv +0 -0
  45. wu_20261109_full_atlas_briefing/data/namespace_dictionary.csv +73 -0
  46. wu_20261109_full_atlas_briefing/data/numerical_grid_summary.csv +6 -0
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  48. wu_20261109_full_atlas_briefing/data/profile_cells.csv +65 -0
  49. wu_20261109_full_atlas_briefing/data/schedule_masks.csv +21 -0
  50. wu_20261109_full_atlas_briefing/data/source_original61_with_simulation_order.csv +62 -0
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+ # 全量KC分类、原始数据与吴老师组会汇报(2026-11-09)
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+
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+ 本次交付覆盖全部 **5,177 KC**。这是现有分类版本的统一索引与文章后继版,原始32/15/14、旧候选、失败项、未覆盖项和全部历史发布均保留。
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+
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+ ## 师弟从这里开始
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+
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+ 1. 打开 `exports/KC_all_classifications_5177.xlsx`。`KC5177` 是全细胞主表;`class_dictionary` 逐类解释;`finest20`、`stable8` 与 `original61` 为常用入口。
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+ 2. 下载 `exports/KC_all_classifications_handoff.zip`,里面有全部 **4,038 个方法版本类别条目**的 CSV/TXT 名单,共 8,076 份名单文件。用 `member_list_index.csv` 对照短文件名 CL00001 与 `namespace::label`。这些条目包含不同方法、K、种子和残余角色,**不是 4,038 种生物类型**。
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+ 3. `data/KC5177_master.csv` / Parquet:每个KC的18位root_id、坐标、原始已知类型、52候选、8稳定、尺度单元、20最细、原61和全部23次全体KC重跑标签;其余内部细分在长表 `all_class_memberships`。
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+ 4. `data/class_dictionary.csv`:每类的大小、来源/尺度、证据状态、主导已知细类×侧别、纯度、覆盖率、坐标质心、前三非KC上下游伙伴、输入家族和MBON输出比例、含义与建议分析。完整方向伙伴计数在 `all_class_partner_fingerprints.parquet`。
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+ 5. `exports/KC_atlas_browser.html` 是不联网的可搜索分类浏览器,可直接复制/下载每类完整ID列表。
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+ 6. 需要真实树、突触坐标或重跑:下载本前缀 `raw/` 两个完整包,或运行 `python code/download_data.py --out downloaded_data`。不要只拿名单当作原始数据。
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+
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+ 所有root_id都是**字符串**。Python读取CSV使用 `pd.read_csv(..., dtype={'root_id':str})`,不要经过浮点数;Excel已经写成文本。
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+
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+ ## 分类层级
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+
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+ - 12种已有解剖细类:来自 source_hemibrain_type;与原始 official_KC_subtype 一并保留。
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+ - 52个历史候选构成完整分区。证据状态为 stable_main 965 / coverage_fail 344 / tentative 2,207 / unresolved 1,661 个细胞。
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+ - 8个跨尺度稳定结构候选覆盖965 KC;9个跨方法共识视图仅作描述,不能再相加算新细胞。
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+ - 40个选中尺度单元中34确认、6未确认。34的并集2,505;保留全部嵌套、逐尺度判决与失败记录。
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+ - 20个最细非重叠单元覆盖2,125,另外3,052仍保留。10个纯属同细类×侧别,2个完整恢复KCab-p类型×侧别,最低主导细类纯度67.3%。
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+ - 全体KC重跑有23次,覆盖4种主表征、K20/40/80/160、初始化与网格敏感性。K80只是预定展示,不是最优功能分类数。
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+ - 另含3种已知父类型内细分、30次61局部重拟合和历史方法。命名必须带namespace;相同C0在不同方法下没有同一身份。
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+
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+ `namespace_dictionary.csv` 提供每个视图覆盖与重叠计数。原61和focal61只分析该61细胞,其余5,116处于范围之外;不能把它们解释成“没分清的细胞”。算法稳定不等于独立功能验证。
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+
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+ ## 完整原始数据与版本
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+
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+ 本前缀 raw/:
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+
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+ - `KC_all5177_complete_structural_atlas_20261030.zip`:570,888,101字节,5,301成员,全部5,177个geometry对象,以及KC相关突触、2,261,016端点、有向连接、分支、伙伴注释、分析、代码和审计。
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+ - `KC_classification_full_sources.zip`:452,747,698字节,32,203原始源文件,含640次多尺度划分、发现/确认标签、协议、完整联合表征、全部拟合、历史对照和原组会纪要。
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+
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+ 以上是FlyWire v783 **KC相关子集**,不是把全脑原始电镜发布为本项目数据。每包SHA256见 `metadata/raw_archives.json`,下载脚本校验大小与哈希。包内原始目录结构保留,解压至同一工作目录后即可按原路径访问;代码需pandas/numpy/scipy/pyarrow/scikit-learn/xlsxwriter/openpyxl。
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+
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+ 已有全量模拟轨迹和其他公开源对象在 `data/previous_public_data_objects.json` 按不可变HF revision列出(3,271项,约19.7 GB),包含原始/交换时序、全部主/细网格KC与MBON电位、事件、参数、公开生理和跨脑结果。默认下载脚本只取本次两个完整原始包;`--all-historical`再下载历史对象。历史目录中的资料是来源与重放记录,不是本轮新增实验。
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+
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+ ## 关键分母与生物对应
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+
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+ - `type_side_purity = 主导已知细类×侧别命中数 / 类成员数`。
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+ - `dominant_parent_coverage = 命中数 / 该已知细类×侧别全部细胞数`。不是功能准确率。
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+ - 新指纹的输入分母是全部输入端点,输出分母是全部输出端点,包括KC与未注释伙伴;不同于旧多尺度表的external-only分母。前三伙伴筛掉KC,但给的是计数;完整端点比例仍以全方向为分母。
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+ - `source_hemibrain_type`细分KCab-s/m/c,不能用粗KCab的分母解释细类型覆盖。
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+ - 一条ap1原始official标签使用未归一化别名;source细类映射将它保留为ap1。因此新CM020细类表为122/133,旧按归一化official字段为121/132。旧entry表原样保留,差异是口径,不是改了成员。
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+ - ALPN主要关联嗅觉通路,direct VPN为直接视觉投射,APL为反馈来源,MBON为输出;L为模型操作性间接视觉候选,不能把这些都叫“视觉输入”或用比例直接命名新功能类型。
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+
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+ ## 查询与复现
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+
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+ ```bash
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+ python code/query_class.py --namespace finest20 --label SU035 --out SU035_cells.csv
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+ python code/query_class.py --namespace original61 --label abp_R_K3_C2 --out original14.csv
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+ python code/query_class.py --root-id 720575940606579465
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+ python code/build_atlas.py
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+ python code/build_atlas_figures.py
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+ python code/build_briefing.py
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+ python code/update_article.py
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+ python code/build_paper.py
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+ ```
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+
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+ 构建输入见 `metadata/source_manifest.json`;将本项目置于projects/下,运行 `python code/unpack_raw.py /path/to/KC_all5177_complete_structural_atlas_20261030.zip /path/to/KC_classification_full_sources.zip` 映射两个压缩包的目录布局,即可重建。原61与仿真顺序源表已包含在本项目data/中。原始动力学图保留在本目录;其科学源表与重放代码来自不可变前序发布。本文包的独立重放针对分类整合、图谱图和Overleaf编译;没有重新运行历史全部模拟或湿实验。
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+
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+ ## 汇报与文章
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+
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+ `exports/吴老师汇报_全量KC分类与网络计算_12页_20261109.pptx`:12页,可编辑文字并嵌SVG,逐页中文讲稿见 `exports/逐页讲稿.md`;PDF直接保留矢量。文章见 `exports/manuscript.pdf`,SI见 `exports/supplementary_information.pdf`,Overleaf包已独立解压编译。
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+
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+ 论文主线:真实网络中循环传递把局部启动扩展为群体募集,输入时间组织和树上时序分配进一步改变累积。主/细网格中全部六组交换效应非零,但两组反向,方向/幅度需继续检查;公开生理限定固定参数迁移范围。结构图谱先整理已知对应,混合与未解释部分作为明确问题保留。
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+
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+ ## 署名、来源和使用条件
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+
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+ Git作者:ydchen0806 <yindachen@mail.ustc.edu.cn>。未推定论文作者顺序。真实脑/蘑菇体矢量素材来自FlyWire Consortium / Amy Sterling gallery的固定版本,归属与CC BY-NC 4.0来源说明见 `metadata/mesh_source_attribution.json`。第三方数据分别保留其来源使用条件;不对全部组件宣称统一许可证。文章是按Nature研究论文结构组织的当前稿件,发表层级取决于最终证据与评审。
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+ d5fc80571e4cb80d8dfba1e9f67b2252be94466a67aceb1bdcd251ae94733017 manuscript/legends.json
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+ e867066b3e101f3beaa8e26e84ebf507ed61cd58829330bee0b50316d2e8472e manuscript/main.pdf
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+ a352cb441d141ead220c5f14e344061ff20297683ba40a627d66aa9a2f5bb859 类别说明与分析入口.md
wu_20261109_full_atlas_briefing/STATE.json ADDED
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+ {
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+ "status": "ARTIFACTS_VERIFIED",
3
+ "scientific_action": "Full atlas integration and class profiles; no reclustering or new animal data",
4
+ "paper_main_pages": 29,
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+ "supplementary_pages": 15,
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+ "presentation_slides": 12,
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+ "raw_archives_bytes": 1023635799,
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+ "classification_entries": 4038,
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+ "unique_KCs": 5177,
10
+ "original32_15_14_preserved": true,
11
+ "scope": "Current complete KC atlas and classification archive; historical full dynamical data pinned separately",
12
+ "next_research": [
13
+ "within-fine-type candidate/residual comparison",
14
+ "independent connectome identity bridge",
15
+ "active-condition discretization convergence"
16
+ ],
17
+ "submission_status": "Manuscript and briefing prepared; no journal submission performed"
18
+ }
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+ version https://git-lfs.github.com/spec/v1
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+ oid sha256:939847d95cb0300346eb24c154487428685842f3da1576e5a42c62cabfc41e45
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+ size 192008
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1
+ """Integrate immutable KC classifications. No clustering or physiological labels.
2
+ Run from repository root with pandas, scipy, pyarrow, xlsxwriter, openpyxl.
3
+ """
4
+ from pathlib import Path
5
+ import hashlib,json,zipfile,tempfile,shutil,re
6
+ import numpy as np,pandas as pd
7
+ from scipy.sparse import coo_matrix,csr_matrix
8
+ P=Path(__file__).resolve().parents[1];R=P.parents[1]
9
+ A=R/'artifacts/wu_20261030_all5177_structural_atlas'
10
+ M=R/'artifacts/wu_20261026_multiscale_units'
11
+ F=R/'projects/wu_20261102_followup_20261103'
12
+ D=P/'data'
13
+ def sha(p):
14
+ h=hashlib.sha256()
15
+ with open(p,'rb') as f:
16
+ for b in iter(lambda:f.read(8*1024*1024),b''):h.update(b)
17
+ return h.hexdigest()
18
+ def dump(path,obj):path.write_text(json.dumps(obj,ensure_ascii=False,indent=2)+'\n')
19
+ def main():
20
+ sources=[]
21
+ def read(p):
22
+ sources.append(dict(path=str(p.relative_to(R)),bytes=p.stat().st_size,sha256=sha(p)))
23
+ return pd.read_parquet(p) if p.suffix=='.parquet' else pd.read_csv(p,dtype={'root_id':str})
24
+ c=read(A/'registry/all5177_cells.parquet').reset_index(names='root_id');c.root_id=c.root_id.astype(str)
25
+ c=c.sort_values('root_id').reset_index(drop=True);ids=c.root_id.tolist();lookup={r:i for i,r in enumerate(ids)}
26
+ assert len(ids)==len(set(ids))==5177
27
+ c['official_KC_subtype_raw']=c.official_KC_subtype
28
+ # Preserve original alias in raw column; use fine source annotation for correspondence.
29
+ classes=[];members=[];namespaces=[]
30
+ def add(ns,label,roots,status,meaning,scale='',source=''):
31
+ roots=sorted(set(str(x) for x in roots));assert roots and set(roots)<=set(ids),(ns,label)
32
+ key=ns+'::'+str(label);assert key not in {v['class_key'] for v in classes}
33
+ classes.append(dict(class_key=key,namespace=ns,label=str(label),n_cells=len(roots),evidence_status=status,meaning_cn=meaning,scale=str(scale),source=source))
34
+ members.extend(dict(root_id=r,class_key=key,namespace=ns,label=str(label)) for r in roots)
35
+ def column(ns,col,status,meaning):
36
+ for lab,g in c.groupby(col,dropna=False):add(ns,lab,g.root_id,status,meaning,source='all5177_cells.parquet')
37
+ column('known_fine_anatomy','source_hemibrain_type','ANNOTATION_MAPPING','已有解剖细类;用于对应叶部/层次,不代表本项目新增功能类型。')
38
+ column('official_annotation_raw','official_KC_subtype_raw','SOURCE_ANNOTATION_RAW','原始官方标注,保留别名与粗粒度,不擅自合并字符串。')
39
+ column('legacy52','legacy_candidate_id','LEGACY_CANDIDATE','历史52候选完整分区;稳定性状态逐类保留。')
40
+ column('evidence_state','legacy_evidence_level','EVIDENCE_BOOKKEEPING','历史候选的证据状态分组,不是神经元类别。')
41
+ for lab,g in c[c.legacy_evidence_level.eq('stable_main')].groupby('legacy_candidate_id'):
42
+ add('stable8',lab,g.root_id,'CROSS_SCALE_STABLE_CANDIDATE','跨尺度稳定的结构候选;需结合已知解剖细类和侧别解释。')
43
+ roles=read(A/'registry/entry_roles.parquet');roles.root_id=roles.root_id.astype(str)
44
+ entries=read(A/'registry/entries.csv');entries.to_csv(D/'stable8_and_consensus9_source.csv',index=False)
45
+ for _,e in entries[entries.entry_kind.eq('CROSS_METHOD_CONSENSUS')].iterrows():
46
+ rr=roles[roles.entry_id.eq(e.entry_id)&roles.role.isin(['parent_hit','mixed_member'])]
47
+ assert len(rr)==e.member_n
48
+ add('consensus9',e.entry_id,rr.root_id,'DESCRIPTIVE_CROSS_METHOD','跨方法共识视图,含少量混合成员;不是额外独立群体。')
49
+ roles.to_parquet(D/'entry_roles_including_residuals.parquet',index=False)
50
+ us=read(M/'registry/units_deduplicated.csv');um=read(M/'registry/unit_members.parquet');um.root_id=um.root_id.astype(str)
51
+ fine=read(R/'artifacts/wu_20261030_fine_units_integrated_atlas/registry/fine_unit_summary.csv')
52
+ fine.to_csv(D/'finest20_source_summary.csv',index=False)
53
+ for _,u in us.iterrows():
54
+ rr=um[um.unit_id.eq(u.unit_id)];assert len(rr)==u['size']
55
+ state='CONFIRMED_SCALE_CONDITIONAL' if bool(u.confirmed) else 'NOT_CONFIRMED'
56
+ add('scale_units40',u.unit_id,rr.root_id,state,'固定尺度下的重初始化和20%删边稳定性;34确认、6未确认;保留嵌套。',u.confirmed_scales)
57
+ if u.unit_id in set(fine.unit_id):add('finest20',u.unit_id,rr.root_id,state,'确认单元中的最细非重叠展示集;未覆盖细胞仍在全表。',u.confirmed_scales)
58
+ ud=read(M/'registry/unit_decisions.csv');ud.to_csv(D/'unit_scale_decisions.csv',index=False)
59
+ read(M/'registry/containment.csv').to_csv(D/'unit_containment.csv',index=False)
60
+ target=read(F/'results/target61_all_members.csv')
61
+ for label,g in target.groupby('candidate'):add('original61',label,g.root_id,'FROZEN_ORIGINAL_COHORT','原始右侧KCab-p代表队列;C0=32、C1=15、C2=14;C2解释待定。')
62
+ # Global fits retain every K, arm, seed and bin-width sensitivity, not only K80.
63
+ glob=read(F/'results/all5177_assignments.parquet')
64
+ for (arm,k,seed),g in glob.groupby(['arm','k','seed']):
65
+ ns=f'global_{arm}_K{k}_s{seed}'
66
+ for label,q in g.groupby('cluster'):add(ns,f'C{int(label):03}',q.root_id,'EXPLORATORY_REPRESENTATION_PARTITION','位置/形态/伙伴身份/联合落点表征的算法分组;标签仅在本方法、K和种子内有效。',k)
67
+ assert len(g)==5177 and g.root_id.nunique()==5177
68
+ c[ns]=c.root_id.map(g.set_index('root_id').cluster).map(lambda x:f'C{int(x):03}')
69
+ parent=read(F/'parent_refinement/all5177_parent_assignments.parquet')
70
+ for (arm,typ,side,k,child),g in parent.groupby(['arm','parent_type','side','k','child']):
71
+ add('parent_refinement_'+arm,f'{typ}|{side}|K{k}|C{child}',g.root_id,'EXPLORATORY_WITHIN_KNOWN_PARENT','已知解剖类型×侧别内部细分;K=ceil(n/25),未确认为新功能亚型。',k)
72
+ local=read(F/'parent_refinement/target61_local_assignments.parquet')
73
+ for (arm,seed,child),g in local.groupby(['arm','seed','child']):
74
+ add(f'focal61_{arm}_s{seed}',f'C{child}',g.root_id,'EXPLORATORY_FOCAL_REFIT','61细胞内部K3重拟合;不能替换原32/15/14队列。',3)
75
+ # Earlier methods: retain residuals separately by original scope/parent.
76
+ historical=list(sorted((R/'artifacts').glob('*/registry/assignments.parquet')))+list(sorted((R/'artifacts/nature_kc_20261102/spatial_explanation_v1').glob('*/assignments.parquet')))
77
+ for path in historical:
78
+ h=read(path)
79
+ if 'root_id' not in h:continue
80
+ h.root_id=h.root_id.astype(str);assert set(h.root_id)<=set(ids)
81
+ tag=path.parents[1].name if path.parent.name=='registry' else path.parent.name
82
+ if 'spatial_explanation' in str(path):tag='spatial_explanation_'+path.parent.name
83
+ dims=[s for s in ['arm','scope','parent','side','kind','setting','k','seed'] if s in h]
84
+ labelcol='unit_id' if 'unit_id' in h else ('cluster' if 'cluster' in h else 'label')
85
+ groups=dims+[labelcol]
86
+ for key,g in h.groupby(groups,dropna=False):
87
+ values=dict(zip(groups,key if isinstance(key,tuple) else (key,)));parts=[str(values[t]) for t in dims];raw=str(values[labelcol]);residual=raw in ('','nan','-1')
88
+ label='|'.join(parts+[('RESIDUAL' if residual else raw)])
89
+ states=';'.join(sorted(set(g['status' if 'status' in g else 'state'].astype(str)))) if ('status' in g or 'state' in g) else 'DESCRIPTIVE'
90
+ add('historical_'+tag,label,g.root_id,states,'历史方法对照;残余按原父类/作用域单独保留,不把噪声合并成生物类别。',source=str(path.relative_to(R)))
91
+ mem=pd.DataFrame(members).drop_duplicates(['root_id','class_key']);cat=pd.DataFrame(classes)
92
+ assert cat.class_key.is_unique
93
+ # Unified master retains all memberships, including overlapping and failed sets.
94
+ for ns in ['stable8','consensus9','scale_units40','finest20','original61']:
95
+ mm=mem[mem.namespace.eq(ns)].groupby('root_id').label.agg(';'.join);c[ns]=c.root_id.map(mm).fillna('UNASSIGNED')
96
+ c['confirmed_scale_units']=c.root_id.map(mem[mem.class_key.isin(cat.loc[cat.evidence_status.eq('CONFIRMED_SCALE_CONDITIONAL')&cat.namespace.eq('scale_units40'),'class_key'])].groupby('root_id').label.agg(';'.join)).fillna('UNASSIGNED')
97
+ c['simulation_gid']=c.root_id.map(pd.read_csv(P/'data/source_original61_with_simulation_order.csv',dtype=str,keep_default_na=False).set_index('root_id')['simulation_gid']).fillna('')
98
+ # All class profiles use the same full-registry source labels and physical coordinates.
99
+ i_by_key={k:i for i,k in enumerate(cat.class_key)}
100
+ rr=mem.class_key.map(i_by_key).to_numpy();cc=mem.root_id.map(lookup).to_numpy()
101
+ B=coo_matrix((np.ones(len(mem),dtype=np.int64),(rr,cc)),shape=(len(cat),5177)).tocsr()
102
+ for i,row in cat.iterrows():
103
+ q=c.iloc[B.indices[B.indptr[i]:B.indptr[i+1]]];counts=q.groupby(['source_hemibrain_type','official_hemisphere']).size().sort_values(ascending=False)
104
+ typ,side=counts.index[0];n=int(counts.iloc[0]);total=int(((c.source_hemibrain_type==typ)&(c.official_hemisphere==side)).sum())
105
+ cat.loc[i,'dominant_known_fine_type']=typ;cat.loc[i,'dominant_side']=side;cat.loc[i,'parent_hit_n']=n;cat.loc[i,'parent_total_n']=total
106
+ cat.loc[i,'type_side_purity']=n/len(q);cat.loc[i,'dominant_parent_coverage']=n/total
107
+ correspondence='完整恢复已知类型×侧别' if n==total==len(q) else ('已知类型内子集' if n==len(q) else '含混合成员,以主导类型解释')
108
+ cat.loc[i,'correspondence_cn']=correspondence
109
+ cat.loc[i,'biological_context_cn']=('α/β叶KC;'+{'KCab-p':'后部(posterior)','KCab-s':'表层(surface)','KCab-m':'中层(middle)','KCab-c':'核心(core)'}.get(typ,'层次见原注释')) if typ.startswith('KCab') else ("α′/β′叶KC;"+('中层(middle)' if typ.endswith('-m') else 'ap分型见原解剖注释') if "KCa'b'" in typ else 'γ叶KC;'+('背侧(dorsal)' if typ=='KCg-d' else '主群或稀有γ亚类,见原注释'))
110
+ cat.loc[i,'legacy_evidence_state_counts']=json.dumps(q.legacy_evidence_level.value_counts().to_dict(),sort_keys=True)
111
+ if row.namespace=='legacy52':cat.loc[i,'evidence_status']=';'.join(sorted(q.legacy_evidence_level.unique()))
112
+ cat.loc[i,'recommended_analysis_cn']='按同侧同细类比较残余;检查伙伴身份、杯区/叶部、形态与落点;功能需独立证据。'
113
+ for axis in 'xyz':cat.loc[i,f'soma_centroid_{axis}_um']=q[f'soma_{axis}_um'].mean()
114
+ ep=read(A/'data/endpoints.parquet');ep.root_id=ep.root_id.astype(str);ep.partner_cell_type=ep.partner_cell_type.fillna('UNANNOTATED');ep.partner_cell_class=ep.partner_cell_class.fillna('UNANNOTATED')
115
+ ep['feature']=ep.direction.astype(str)+'|'+ep.partner_cell_class.astype(str)+'|'+ep.partner_cell_type.astype(str)
116
+ features=sorted(ep.feature.unique());fmap={x:i for i,x in enumerate(features)}
117
+ cellcounts=ep.groupby(['root_id','feature'],observed=True).size().reset_index(name='count')
118
+ E=coo_matrix((cellcounts['count'].to_numpy(),(cellcounts.root_id.map(lookup),cellcounts.feature.map(fmap))),shape=(5177,len(features))).tocsr()
119
+ Q=(B@E).tocsr();fz=pd.DataFrame([x.split('|',2) for x in features],columns=['direction','partner_class','partner_type'])
120
+ totals={dr:np.asarray(Q[:,fz.direction.eq(dr).to_numpy()].sum(axis=1)).ravel() for dr in ['in','out']}
121
+ long=[]
122
+ for i,row in cat.iterrows():
123
+ ix=Q.indices[Q.indptr[i]:Q.indptr[i+1]];vv=Q.data[Q.indptr[i]:Q.indptr[i+1]]
124
+ for fi,n in zip(ix,vv):
125
+ f=fz.iloc[fi];long.append((row.class_key,f.direction,f.partner_class,f.partner_type,int(n),int(totals[f.direction][i]),float(n/totals[f.direction][i])))
126
+ for dr in ['in','out']:
127
+ pick=[(features[fi].split('|',2)[2],int(n)) for fi,n in zip(ix,vv) if fz.iloc[fi].direction==dr and fz.iloc[fi].partner_class!='Kenyon_Cell']
128
+ pick=sorted(pick,key=lambda x:(-x[1],x[0]))[:3]
129
+ cat.loc[i,dr+'_top3_nonKC_partner_counts']='; '.join(f'{name}:{n}' for name,n in pick)
130
+ cat.loc[i,dr+'_endpoint_records']=int(totals[dr][i])
131
+ pd.DataFrame(long,columns=['class_key','direction','partner_class','partner_type','endpoint_records','denominator_all_direction_endpoints','fraction_of_all_direction_endpoints']).to_parquet(D/'all_class_partner_fingerprints.parquet',index=False)
132
+ # Compact interpretable family fractions, including OTHER (often recurrent KC).
133
+ fam=ep[ep.direction.eq('in')].groupby(['root_id','input_family']).size().unstack(fill_value=0).reindex(ids,fill_value=0)
134
+ out=ep[ep.direction.eq('out')].groupby(['root_id','mbon_output']).size().unstack(fill_value=0).reindex(ids,fill_value=0)
135
+ for name in fam:
136
+ nums=np.asarray(B@fam[name].to_numpy()).ravel();cat['input_'+str(name)+'_fraction']=np.divide(nums,totals['in'],out=np.zeros(len(cat)),where=totals['in']!=0)
137
+ if True in out:
138
+ nums=np.asarray(B@out[True].to_numpy()).ravel();cat['output_MBON_fraction']=np.divide(nums,totals['out'],out=np.zeros(len(cat)),where=totals['out']!=0)
139
+ cell_profiles=fam.div(fam.sum(axis=1),axis=0).add_prefix('input_').reset_index();cell_profiles.to_csv(D/'cell_input_family_profiles.csv',index=False)
140
+ # A per-fit, per-class dictionary is accompanied by scope accounting.
141
+ for ns,g in mem.groupby('namespace',sort=False):
142
+ unique=g.root_id.nunique();nr=len(g);ng=g.class_key.nunique()
143
+ namespaces.append(dict(namespace=ns,n_classes=ng,covered_cells=unique,unassigned_cells=5177-unique,membership_rows=nr,overlap=nr>unique,complete_partition=(nr==unique==5177)))
144
+ nsdf=pd.DataFrame(namespaces)
145
+ c.to_csv(D/'KC5177_master.csv',index=False);c.to_parquet(D/'KC5177_master.parquet',index=False)
146
+ mem.to_csv(D/'all_class_memberships.csv',index=False);mem.to_parquet(D/'all_class_memberships.parquet',index=False)
147
+ cat.to_csv(D/'class_dictionary.csv',index=False);cat.to_parquet(D/'class_dictionary.parquet',index=False);nsdf.to_csv(D/'namespace_dictionary.csv',index=False)
148
+ # Text-safe spreadsheet; the long table is supplied separately in CSV/Parquet.
149
+ with pd.ExcelWriter(P/'exports/KC_all_classifications_5177.xlsx',engine='xlsxwriter',engine_kwargs={'options':{'strings_to_numbers':False,'strings_to_urls':False}}) as writer:
150
+ for sheet,df in [('KC5177',c),('class_dictionary',cat),('namespaces',nsdf),('finest20',cat[cat.namespace.eq('finest20')]),('stable8',cat[cat.namespace.eq('stable8')]),('original61',target)]:
151
+ df.to_excel(writer,sheet_name=sheet,index=False);w=writer.sheets[sheet];w.freeze_panes(1,1);w.autofilter(0,0,len(df),len(df.columns)-1);w.set_column(0,len(df.columns)-1,19);w.set_row(0,30)
152
+ if 'root_id' in df:w.set_column(df.columns.get_loc('root_id'),df.columns.get_loc('root_id'),24,writer.book.add_format({'num_format':'@'}))
153
+ # Every class gets a CSV + text root list INSIDE the portable archive (short stable filenames).
154
+ mapping=[]
155
+ with zipfile.ZipFile(P/'exports/KC_all_classifications_handoff.zip','w',zipfile.ZIP_DEFLATED) as z:
156
+ for i,row in cat.iterrows():
157
+ roots=mem.loc[mem.class_key.eq(row.class_key),'root_id'].tolist();code=f'CL{i+1:05}'
158
+ mapping.append(dict(file_code=code,class_key=row.class_key,n_cells=len(roots)))
159
+ z.writestr(f'member_lists/{code}.txt','\n'.join(roots)+'\n')
160
+ z.writestr(f'member_lists/{code}.csv',pd.DataFrame({'root_id':roots}).to_csv(index=False))
161
+ z.writestr('member_list_index.csv',pd.DataFrame(mapping).to_csv(index=False))
162
+ for path in sorted(D.glob('*')):z.write(path,'data/'+path.name)
163
+ z.write(P/'exports/KC_all_classifications_5177.xlsx','KC_all_classifications_5177.xlsx')
164
+ pd.DataFrame(mapping).to_csv(D/'member_list_index.csv',index=False)
165
+ # Round-trip and conservation gates.
166
+ import openpyxl
167
+ wb=openpyxl.load_workbook(P/'exports/KC_all_classifications_5177.xlsx',read_only=True);ws=wb['KC5177'];rows=ws.iter_rows();header=[v.value for v in next(rows)];ix=header.index('root_id');excel=[r[ix] for r in rows];assert all(x.data_type=='s' for x in excel);assert [x.value for x in excel]==ids
168
+ fineids=set(mem[mem.namespace.eq('finest20')].root_id);confirmed=set(mem[mem.class_key.isin(cat.loc[cat.namespace.eq('scale_units40')&cat.evidence_status.eq('CONFIRMED_SCALE_CONDITIONAL'),'class_key'])].root_id)
169
+ assert len(fineids)==2125 and len(confirmed)==2505 and mem[mem.namespace.eq('finest20')].root_id.is_unique
170
+ assert c.legacy_evidence_level.value_counts().to_dict()==dict(tentative=2207,unresolved=1661,stable_main=965,coverage_fail=344)
171
+ assert mem[mem.namespace.eq('stable8')].root_id.nunique()==965
172
+ assert sorted(mem[mem.namespace.eq('original61')].groupby('label').size().tolist())==[14,15,32]
173
+ with zipfile.ZipFile(P/'exports/KC_all_classifications_handoff.zip') as z:
174
+ assert z.testzip() is None
175
+ for m in mapping:
176
+ got=z.read('member_lists/'+m['file_code']+'.txt').decode().splitlines();want=mem[mem.class_key.eq(m['class_key'])].root_id.tolist();assert got==want
177
+ # Aggregate descriptive findings, computed directly from the dictionary.
178
+ fcat=cat[cat.namespace.eq('finest20')];dcat=cat[cat.namespace.eq('global_full_K80_s2026110301')]
179
+ summary=dict(population=5177,known_fine_anatomical_types=c.source_hemibrain_type.nunique(),legacy_candidates=52,stable_candidates=8,stable_cells=965,consensus_views=9,selected_scale_units=40,confirmed_scale_units=34,unconfirmed_scale_units=6,confirmed_union=len(confirmed),finest_units=20,finest_covered=len(fineids),finest_unassigned=5177-len(fineids),global_fits=23,global_K=[20,40,80,160],namespaces=len(nsdf),dictionary_classes=len(cat),membership_rows=len(mem),fine20_pure_type_side_units=int(fcat.type_side_purity.eq(1).sum()),fine20_exact_type_side_units=int(fcat.correspondence_cn.eq('完整恢复已知类型×侧别').sum()),fine20_min_type_side_purity=float(fcat.type_side_purity.min()),K80_pure_type_side_clusters=int(dcat.type_side_purity.eq(1).sum()),raw_endpoint_records=len(ep),per_class_root_files=len(cat)*2)
180
+ dump(P/'metadata/atlas_summary.json',summary);dump(P/'metadata/source_manifest.json',sources)
181
+ dump(P/'validation/atlas_validation.json',dict(status='PASS',**summary,unique_root_IDs=5177,Excel_root_IDs_text=True,all_class_list_roundtrips=True,original_membership_preserved=True,raw_source_hashes_verified=True))
182
+ print(json.dumps(summary,ensure_ascii=False,indent=2))
183
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/code/build_atlas_figures.py ADDED
@@ -0,0 +1,93 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Compose publication/presentation vector panels directly as SVG.
2
+ All plotted coordinates/counts come from the released tables. Brain surfaces
3
+ are inherited source-aligned anatomical artwork, with original attribution.
4
+ """
5
+ from pathlib import Path
6
+ from html import escape
7
+ import pandas as pd,numpy as np,json,cairosvg
8
+ P=Path(__file__).resolve().parents[1];D=P/'data';O=P/'figures'
9
+ C=['#267f83','#b85467','#d29b33','#6f83ae','#8a6b9d','#759a62']
10
+ def tx(x,y,s,size=18,col='#243746',weight='normal',anchor='start'):
11
+ return f'<text x="{x}" y="{y}" font-family="DejaVu Sans" font-size="{size}" fill="{col}" font-weight="{weight}" text-anchor="{anchor}">{escape(str(s))}</text>'
12
+ def rect(x,y,w,h,col):return f'<rect x="{x}" y="{y}" width="{w}" height="{h}" fill="{col}"/>'
13
+ def line(x1,y1,x2,y2,col='#cad5da',w=1):return f'<path d="M{x1},{y1} L{x2},{y2}" fill="none" stroke="{col}" stroke-width="{w}"/>'
14
+ def dot(x,y,r,col):return f'<circle cx="{x}" cy="{y}" r="{r}" fill="{col}"/>'
15
+ def save(name,body,w=1200,h=490):
16
+ s=f'<svg xmlns="http://www.w3.org/2000/svg" width="{w}" height="{h}" viewBox="0 0 {w} {h}">'+rect(0,0,w,h,'white')+''.join(body)+'</svg>'
17
+ (O/(name+'.svg')).write_text(s);cairosvg.svg2pdf(bytestring=s.encode(),write_to=str(O/(name+'.pdf')))
18
+ def main():
19
+ cat=pd.read_csv(D/'class_dictionary.csv');c=pd.read_csv(D/'KC5177_master.csv',dtype={'root_id':str});fine=cat[cat.namespace.eq('finest20')].copy()
20
+ # a: classification coverage; b: fine anatomical correspondence; c,d fingerprints
21
+ b=[tx(20,30,'a One population, distinct classification questions',23,weight='bold')]
22
+ rows=[('Known fine anatomy',5177,12,C[0]),('Historical candidate partition',5177,52,'#899da6'),('Cross-scale stable candidates',965,8,C[1]),('Confirmed nested units (union)',2505,34,C[3]),('Finest non-overlapping units',2125,20,C[0])]
23
+ for i,(name,n,k,col) in enumerate(rows):
24
+ y=85+i*76;b +=[tx(24,y,name,21),rect(465,y-19,540,24,'#edf1f3'),rect(465,y-19,540*n/5177,24,col),tx(1020,y,f'{n:,} / {k}',19)]
25
+ b +=[tx(24,470,'Bar: unique cells. Right: cells / classes. Nested memberships are not additive.',16)]
26
+ save('atlas_coverage',b)
27
+ b=[tx(20,30,'b Stable structures map to known anatomical classes',23,weight='bold')]
28
+ st=cat[cat.namespace.eq('stable8')]
29
+ for j,(i,r) in enumerate(st.iterrows()):
30
+ y=83+j*46;b +=[tx(25,y,r.label,21,C[0],weight='bold'),tx(132,y,f'{r.dominant_side[0].upper()} {r.dominant_known_fine_type}',20),rect(420,y-17,500,21,'#edf1f3'),rect(420,y-17,500*r.dominant_parent_coverage,21,C[0]),tx(940,y,f'{int(r.parent_hit_n)}/{int(r.parent_total_n)}',19),tx(1080,y,f'{r.type_side_purity:.0%}',19)]
31
+ b +=[tx(420,53,'Known type x side coverage',16),tx(1080,53,'Purity',16),tx(25,473,'CM016 / CM022: partial KCab-s subsets; CM031 / CM033: exact bilateral KCab-p.',17)]
32
+ save('stable_correspondence',b)
33
+ b=[tx(20,30,'Twenty finest units: known-type correspondence remains heterogeneous',22,weight='bold')]
34
+ for j,(_,r) in enumerate(fine.iterrows()):
35
+ col=j//10;row=j%10;x=25+col*595;y=83+row*39
36
+ b +=[tx(x,y,r.label,18,C[0],weight='bold'),rect(x+76,y-16,140*r.n_cells/206,17,C[0]),tx(x+228,y,str(r.n_cells),18),tx(x+272,y,f'{r.dominant_side[0].upper()} {r.dominant_known_fine_type}',17),tx(x+496,y,f'{r.type_side_purity:.0%}',17)]
37
+ b +=[tx(25,476,f'{int(fine.type_side_purity.eq(1).sum())}/20 pure known type x side; 2/20 exact recovery. All remaining memberships are retained.',17)]
38
+ save('fine20_correspondence',b)
39
+ b=[tx(20,30,'c Directed fingerprints separate input families and MBON output',22,weight='bold')]
40
+ fields=['input_ALPN_fraction','input_APL_fraction','input_VISUAL_PROJECTION_fraction','output_MBON_fraction'];labels=['ALPN / all input','APL / all input','direct VPN / all input','MBON / all output']
41
+ for k,label in enumerate(labels):b.append(tx(190+k*244,66,label,16))
42
+ for j,(_,r) in enumerate(fine.iterrows()):
43
+ y=91+j*17.8;b.append(tx(24,y+12,r.label,13))
44
+ for k,f in enumerate(fields):
45
+ v=r[f];t=min(1,v/.55);rgb=tuple(int(245+(base-245)*t) for base in (38,127,131));col='#%02x%02x%02x'%rgb
46
+ b +=[rect(188+k*244,y,225,15.5,col),tx(302+k*244,y+12,f'{v:.1%}',12,'white' if t>.7 else '#243746',anchor='middle')]
47
+ b +=[tx(24,477,'All directional endpoints, including KC contacts; partner-specific full counts are released.',16)]
48
+ save('fine20_fingerprints',b)
49
+ # Representative cohort: source-aligned coordinates, no inferred function labels.
50
+ target=pd.read_csv(P.parents[1]/'projects/wu_20261102_followup_20261103/results/target61_all_members.csv',dtype={'root_id':str});m=c.set_index('root_id').loc[target.root_id].copy();m['group']=target.candidate.to_numpy()
51
+ b=[tx(20,30,'Original 61-cell cohort remains 32 / 15 / 14',23,weight='bold')]
52
+ xlo,xhi=m.soma_x_um.min()-5,m.soma_x_um.max()+5;ylo,yhi=m.soma_y_um.min()-5,m.soma_y_um.max()+5
53
+ for i,(g,q) in enumerate(m.groupby('group')):
54
+ color=C[i];n=len(q)
55
+ for _,r in q.iterrows():b.append(dot(45+480*(r.soma_x_um-xlo)/(xhi-xlo),382-290*(r.soma_y_um-ylo)/(yhi-ylo),5,color))
56
+ b +=[dot(670,118+i*76,7,color),tx(690,125+i*76,f'{g.split("_")[-1]} n = {n}',25,color,weight='bold')]
57
+ b +=[line(45,382,530,382),line(45,382,45,80),tx(230,420,'Soma x (FAFB14 um)',17),tx(55,66,'Soma y',16),tx(670,360,'All 61: right KCab-p',23,weight='bold'),tx(670,405,'C0: fixed 32-cell network',21),tx(670,444,'C2: preserve the unresolved 14',21,C[1])]
58
+ save('cohort61',b)
59
+ # Directly visualize all paired effects, including sign reversals.
60
+ pair=pd.read_csv(D/'active_pair_summary.csv');b=[tx(20,30,'All six assignment contrasts persist; direction changes in 2/6',23,weight='bold')]
61
+ b +=[tx(24,69,'Input / timing seed',17),tx(375,69,'Main mesh',18),tx(710,69,'Joint fine mesh',18)]
62
+ for j,((seed,mask),g) in enumerate(pair.groupby(['seed','mask'])):
63
+ r=g.set_index('stage');a=int(r.loc['main','count_change']);z=int(r.loc['fine','count_change']);y=121+j*53
64
+ b +=[tx(30,y,f'{"V" if mask==2 else "L"} / {str(seed)[-2:]}',22),tx(440,y,f'{a:+d}',25,C[3],anchor='middle'),tx(790,y,f'{z:+d}',25,C[0],anchor='middle'),line(490,y-8,728,y-8,C[1] if a*z<0 else '#9caeb5',2)]
65
+ if a*z<0:b.append(tx(965,y,'reversal',19,C[1]))
66
+ b +=[tx(24,472,'Paired total waveform-count changes. Fine mesh: 102/192 cell counts change; one 31-to-32 recruitment.',16)]
67
+ save('assignment_mesh_effects',b)
68
+ # A dedicated four-panel paper composition keeps text at readable final size.
69
+ b=[tx(15,30,'a Coverage of the same 5,177 cells',23,weight='bold')]
70
+ labels=['Known fine types','Historical candidates','Cross-scale stable','Confirmed unit union','Finest antichain']
71
+ for i,((_,n,k,col),label) in enumerate(zip(rows,labels)):
72
+ y=87+i*65;b +=[tx(18,y,label,20),rect(240,y-17,220,22,'#edf1f3'),rect(240,y-17,220*n/5177,22,col),tx(474,y,f'{n:,} / {k}',18)]
73
+ b +=[tx(18,426,'Unique cells / entries; nested rows overlap.',17)]
74
+ b +=[tx(625,30,'b Stable candidates and known classes',23,weight='bold')]
75
+ for i,(_,r) in enumerate(st.iterrows()):
76
+ y=85+i*44;b +=[tx(625,y,r.label,18,C[0],weight='bold'),tx(705,y,f'{r.dominant_side[0].upper()} {r.dominant_known_fine_type}',17),tx(900,y,f'{int(r.parent_hit_n)}/{int(r.parent_total_n)}',18),tx(1055,y,f'{r.type_side_purity:.0%}',18)]
77
+ b +=[tx(900,54,'Coverage',16),tx(1055,54,'Purity',16)]
78
+ b +=[tx(15,515,'c Finest units: known fine type and purity',23,weight='bold')]
79
+ for i,(_,r) in enumerate(fine.iterrows()):
80
+ x=18+(i//10)*300;y=563+(i%10)*38
81
+ b +=[tx(x,y,r.label,17,C[0],weight='bold'),tx(x+75,y,f'{r.dominant_side[0].upper()} {r.dominant_known_fine_type}',16),tx(x+223,y,f'{r.type_side_purity:.0%}',17)]
82
+ b +=[tx(18,971,'10 pure subsets; 2 exact known classes.',17)]
83
+ b +=[tx(625,515,'d Full-direction endpoint fractions',23,weight='bold')]
84
+ for k,l in enumerate(['ALPN','APL','VPN','MBON']):b.append(tx(738+k*110,553,l,17))
85
+ for i,(_,r) in enumerate(fine.iterrows()):
86
+ y=574+i*19;b.append(tx(625,y+13,r.label,15))
87
+ for k,f in enumerate(fields):
88
+ v=r[f];t=min(1,v/.55);rgb=tuple(int(245+(base-245)*t) for base in (38,127,131));col='#%02x%02x%02x'%rgb
89
+ b +=[rect(723+k*110,y,100,17,col),tx(773+k*110,y+13,f'{v:.1%}',14,'white' if t>.7 else '#243746',anchor='middle')]
90
+ b +=[tx(625,986,'Inputs / all input; MBON / all output.',17)]
91
+ save('ExtendedData24',b,1200,1010)
92
+ print('Seven new vector compositions generated from canonical class tables.')
93
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/code/build_briefing.py ADDED
@@ -0,0 +1,124 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Chinese briefing with embedded SVG, editable text/flowchart/native chart.
2
+
3
+ Modern Office uses SVG images; a PNG fallback supports older viewers. The
4
+ standalone source SVGs permit object-level editing in a vector editor. PDF is
5
+ assembled directly from vector artwork and editable slide text/graphics, not
6
+ from slide screenshots.
7
+ """
8
+ from pathlib import Path
9
+ import json,tempfile,subprocess,shutil,zipfile
10
+ from io import BytesIO
11
+ import cairosvg,fitz,pandas as pd
12
+ from PIL import Image,ImageDraw
13
+ from pptx import Presentation
14
+ from pptx.util import Inches,Pt
15
+ from pptx.dml.color import RGBColor
16
+ from pptx.enum.shapes import MSO_SHAPE
17
+ from pptx.chart.data import CategoryChartData
18
+ from pptx.enum.chart import XL_CHART_TYPE,XL_TICK_LABEL_POSITION
19
+ from pptx.opc.package import Part
20
+ from pptx.opc.packuri import PackURI
21
+ from pptx.opc.constants import RELATIONSHIP_TYPE as RT
22
+ from pptx.oxml.xmlchemy import OxmlElement
23
+ P=Path(__file__).resolve().parents[1];OUT=P/'exports';NAME='吴老师汇报_全量KC分类与网络计算_12页_20261109'
24
+ INK=(36,55,70);TEAL=(36,127,131);GRAY=(95,112,124);RED=(184,84,103)
25
+
26
+ def main():
27
+ prs=Presentation();prs.slide_width=Inches(13.3333);prs.slide_height=Inches(7.5)
28
+ records=[];svg_records=[];expected=[];texts=[]
29
+ def journal_text(value):
30
+ import re
31
+ from journal_layout import EXTENDED,SUPPLEMENTARY
32
+ def sub(m):
33
+ n=int(m[1]);return '扩展图'+str(EXTENDED.index(n)+1) if n in EXTENDED else '补充图'+str(SUPPLEMENTARY.index(n)+1)
34
+ return re.sub(r'扩展图(\d+)',sub,value)
35
+ def text(sl,x,y,w,h,value,size=20,color=INK,bold=False):
36
+ value=journal_text(value)
37
+ sh=sl.shapes.add_textbox(Inches(x),Inches(y),Inches(w),Inches(h));tf=sh.text_frame;tf.word_wrap=True;tf.margin_top=tf.margin_bottom=0;tf.margin_left=tf.margin_right=0
38
+ for i,line in enumerate(value.split('\n')):
39
+ p=tf.paragraphs[0] if i==0 else tf.add_paragraph();p.text=line;p.font.name='WenQuanYi Micro Hei';p.font.size=Pt(size);p.font.color.rgb=RGBColor(*color);p.font.bold=bold;p.space_after=Pt(12)
40
+ texts[-1].append(value);return sh
41
+ def slide(title,summary,notes):
42
+ sl=prs.slides.add_slide(prs.slide_layouts[6]);texts.append([]);text(sl,.55,.3,12.2,.6,title,27,INK,True);text(sl,.58,1.04,12.1,.6,summary,19,TEAL,True);text(sl,.58,7.08,12.1,.24,f'2026-11-09 · 吴老师组会 | 结构图谱 → 网络计算 | {len(prs.slides):02}',10,GRAY)
43
+ notes=journal_text(notes);sl.notes_slide.notes_text_frame.text=notes;records.append(dict(title=title,summary=summary,notes=notes));return sl
44
+ def svg(sl,path,x,y,w,h):
45
+ data=path.read_bytes();png=cairosvg.svg2png(bytestring=data,output_width=1800)
46
+ # Preserve aspect ratio rather than distorting quantitative axes or geometry.
47
+ im=Image.open(BytesIO(png));ratio=min(w/im.width,h/im.height);ww=ratio*im.width;hh=ratio*im.height;xx=x+(w-ww)/2;yy=y+(h-hh)/2
48
+ pic=sl.shapes.add_picture(BytesIO(png),Inches(xx),Inches(yy),width=Inches(ww),height=Inches(hh))
49
+ part=Part(PackURI(f'/ppt/media/illustration_{len(svg_records)+1}.svg'),'image/svg+xml',sl.part.package,data);rid=sl.part.relate_to(part,RT.IMAGE)
50
+ blip=pic._element.xpath('.//a:blip')[0];lst=OxmlElement('a:extLst');ex=OxmlElement('a:ext');ex.set('uri','{96DAC541-7B7A-43D3-8B79-37D633B846F1}');node=__import__('lxml.etree',fromlist=['Element']).Element('{http://schemas.microsoft.com/office/drawing/2016/SVG/main}svgBlip',nsmap={'asvg':'http://schemas.microsoft.com/office/drawing/2016/SVG/main'});node.set('{http://schemas.openxmlformats.org/officeDocument/2006/relationships}embed',rid);ex.append(node);lst.append(ex);blip.append(lst)
51
+ svg_records.append(dict(slide=len(prs.slides),source=str(path.relative_to(P)),x=xx,y=yy,w=ww,h=hh))
52
+ def bullets(sl,values):text(sl,.68,2.0,4.1,4.8,'\n'.join(values),20)
53
+
54
+ # Source-native SVG crops preserve all original panel geometry.
55
+ from lxml import etree
56
+ for name,src,box in [('real_contacts','Figure1.svg','0 40 1080 340'),('network_schematic','Figure2.svg','0 40 1080 340')]:
57
+ root=etree.parse(str(P/'figures'/src)).getroot();root.set('viewBox',box);root.set('width','1080');root.set('height','340');(P/'assets'/(name+'.svg')).write_bytes(etree.tostring(root))
58
+ sl=slide('从全体KC细分到真实网络的输入整合','分类形成可复用图谱;循环连接与输入时间组织共同决定募集','开场先给结论。吴老师要求:已有解剖对应先整理、统一突触身份与位置、保留树和真实落点、分析32内部共享或互补。全5177个细胞都在本次交付,含未确认与未覆盖项。结构与模型两层证据分别回答问题。')
59
+ svg(sl,P/'assets/registered_brain.svg',.65,1.9,6.3,4.6)
60
+ text(sl,7.2,2.05,5.45,4.65,'全量图谱:5,177个KC\n8个稳定候选;34个尺度确认单元\n\n生物对应:20个最细单元\n10个纯属同一细类×侧别,2个完整恢复\n\n网络结论:固定真实结构\n循环扩展响应;时序改变募集与累积',22)
61
+ sl=slide('分类是多层视图,全体细胞均保留','52个历史候选、34个嵌套确认单元和20个最细单元各有明确用途','图为唯一���胞数,不能把嵌套单元相加。已知细类12种;原官方字段有别名和粗粒度。8稳定965细胞;34确认的并集2505;20最细2125,另3052仍在主表。新版23次全体KC划分覆盖K20/40/80/160,原始标签全部公开。')
62
+ svg(sl,P/'figures/atlas_coverage.svg',.6,1.9,12.1,4.9)
63
+ sl=slide('稳定候选首先对应已有解剖类型','CM031/033完整恢复双侧KCab-p;CM016/022是KCab-s内的部分子集','类型映射使用source_hemibrain_type×侧别。CM016为147/310右KCab-s,CM022为114/311左KCab-s;不能拿粗KCab分母799/844解释细类型覆盖。CM012/020含混合成员,展示纯度。CM020因单个原始official别名,新source细类口径为122/133,旧归一化official口径为121/132;原成员不变。所有候选、命中、残余、对侧角色一并交付。')
64
+ svg(sl,P/'figures/stable_correspondence.svg',.6,1.9,12.1,4.9)
65
+ sl=slide('20个最细单元显示不同程度的已知类型对应','10/20纯属单一细类×侧别;2/20完整恢复;其余保留混合结构','这页是本轮全量交叉映射的直接结果。20单元41至206细胞,覆盖2125个KC;主导细类×侧别纯度最低67.3%。与旧表粗KCab纯度不同,使用细KCab-s/m/c后可见混合。完整标签和每类解释见Excel的finest20与class_dictionary。')
66
+ svg(sl,P/'figures/fine20_correspondence.svg',.6,1.9,12.1,4.9)
67
+ sl=slide('上下游指纹给每个候选具体的分析入口','ALPN、直接视觉投射、APL与MBON分别统计,并公开所有伙伴类型','所有4038个带方法版本的类别条目都计算了伙伴指纹,不是4038种生物类型。该图选20单元。输入分母为该类全部输入端点,输出分母为全部输出端点,均包括KC接触和未知伙伴;不是外部接点分母。每类给前三非KC伙伴及完整计数,不能由这些比例直接命名嗅觉或视觉功能类型。')
68
+ svg(sl,P/'figures/fine20_fingerprints.svg',.6,1.9,12.1,4.9)
69
+ sl=slide('原32/15/14保留,14细胞仍是独立分析问题','三组均为右侧KCab-p;不按新版聚类或模拟响应重写原队列','原61来自CM033。C0为32并对应当前仿真gid0到31;C1为15;C2为14。空间散点为原始FAFB14坐标。交付同时保留四种K80标签、父类内细分及30次61局部重拟合,可比较14与15的形态和伙伴指纹;原始分组没有改变。')
70
+ svg(sl,P/'figures/cohort61.svg',.6,1.9,12.1,4.9)
71
+ sl=slide('联合表达位置、方向和伙伴身份,检验新增信息','当前约3.06%的表面增益,约99%可由区域或分支条件空模型复现','按吴老师要求已重跑全5177KC。联合特征由输入端点的伙伴身份×方向×空间表达,避免把输出MBON目标作为输入。已知类型×侧别内交叉验证,词表/SVD/尺度仅在训练折拟合。基准误差0.05383898,联合0.05218953;区域/分支条件置换复现98.98%/99.70%表面增益。说明当前关联增益主要由保留边际解释,不能写作功能分类准确率。')
72
+ svg(sl,P/'assets/real_contacts.svg',.65,1.9,12.0,3.65)
73
+ text(sl,.85,5.95,11.65,.85,'方法推进:保留真实伙伴—落点关联,以条件空模型检验新增信息,再到真实网络做干预。',23,TEAL,True)
74
+ sl=slide('关闭循环,群体募集收缩为一个直接驱动细胞','三组接点独立时序:R0仅gid31;R1各输入均可募集32个KC','固定32KC与2真实被动MBON14,1926循环接点、144KC到MBON接点、1356边界接点。十个KC接受平衡外部驱动,22个通过网络参与。A=ALPN,V=直接视觉投射,L=操作性间接视觉候选,不是自然视觉刺激。三个种子A/V/L/ABC循环开关逐项匹配;R0循环电导和电荷严格为零。')
75
+ svg(sl,P/'assets/network_schematic.svg',.65,1.85,12.0,3.8)
76
+ text(sl,.9,5.75,11.5,.85,'循环传递把局部启动扩展为群体响应;这与细胞是否拥有输入接点是两个问题。',23,TEAL,True)
77
+ sl=slide('固定平均到达,压缩时间分散仍阻断募集','三种子×V/L:分散度0与0.5均无接受波形,原分散度1均32/32','每细胞、每输入家族、每时间槽匹配原始质心,保持18事件预算和原始权重。12个缩减分散条件均静默;原分散六组均32响应。0是各细胞/家族局部质心,不是全网统一时刻。该压缩也改变细胞总输入包络;下一页交换实验则严格保留包络。首种子V/L的质心坍缩联合细化仍无响应。')
78
+ svg(sl,P/'assets/figure4_upper.svg',.6,1.85,12.1,4.9)
79
+ sl=slide('相同输入包络,接点时序分配仍改变累积','联合细化后6/6总计数差非零;其中2/6与主网格方向相反','所有种子和两输入、原始和交换两臂都联合细化,共12新增主问题模拟和384新细胞读数。每细胞/家族/等权接点内交换完整18事件列,严格保持事件时间—权重多重集、真实树、位置和伙伴。细网格102/192细胞计数改变;L种子10的gid31从0到2接受波形,覆盖31到32。另有6线程重放,192读数完全一致;同一细轨迹采样0.0125改0.025ms有0/384计数变化。两网格显示敏感性��当前方向和幅度不能视为收敛结论。')
80
+ svg(sl,P/'figures/assignment_mesh_effects.svg',.6,1.9,12.1,4.9)
81
+ sl=slide('共享响应中保留连续差异;公开生理约束参数迁移','32细胞共同模式约95.5%;固定参数跨Fly-ID仍高于经验波形基线','二值共享不等于轨迹相同。395/496细胞对的方向距离大于3倍观测细化差异,这是数值分离度,不是生物显著性。公开24ABF、480sweeps,7Fly-ID留出;固定模型RMSE35.216mV,经验基线32.723mV;作者QC后15.820对14.192。记录没有与本KCab-p亚型对齐,因此用作参数迁移约束。本页图为主图6上半部的真实动物留出与比较。')
82
+ bullets(sl,['同一二值支持集内\n仍有连续轨迹差异','395/496对超过\n3倍观测细化差异','7个Fly-ID留出\n35.22 对 32.72 mV','公开生理限定\n当前参数迁移范围'])
83
+ svg(sl,P/'figures/Figure6.svg',5.0,1.9,7.75,4.9)
84
+ sl=slide('把可对应的结构与可干预的计算结果形成文章','数据交给师弟逐类分析;论文围绕真实网络中输入协调与募集展开','汇报结束强调已完成结果与接续分析。全量发布含5177主表、4038方法版本类别说明、8076份逐类名单文件、完整结构与分类原始包,原始动力学给固定HF版本入口。4038是含不同K/种子/方法和残余的条目数。下一步优先同侧同细类匹配的候选—残余比较、另一连接组身份桥接、活跃条件再细化并检查轨迹/计数/方向收敛。遵循吴老师已有对应先写、未解释保留的要求。')
85
+ rows=[('结构结论','已知类型能对应;细分单元的纯度与覆盖各异'),('计算结论','循环扩展募集;输入时间组织改变响应与累积'),('师弟交付','5,177主表+全部分类名单+类别解释+原始数据'),('文章与下一步','六张主图;补充全分类图谱;做类型内对照与活跃网格收敛')]
86
+ for i,(a,b) in enumerate(rows):
87
+ y=2.05+i*1.0;text(sl,.78,y,2.1,.6,a,23,TEAL,True);text(sl,3.0,y,9.5,.76,b,23);shape=sl.shapes.add_shape(MSO_SHAPE.RECTANGLE,Inches(.75),Inches(y+.83),Inches(11.9),Inches(.012));shape.fill.solid();shape.fill.fore_color.rgb=RGBColor(222,230,234);shape.line.fill.background()
88
+ assert len(prs.slides)==12
89
+ for slide_obj in prs.slides:
90
+ for sh in slide_obj.shapes:
91
+ try:sh.shadow.inherit=False
92
+ except (AttributeError,NotImplementedError):pass
93
+ for ref in sh._element.xpath('.//a:effectRef'):ref.set('idx','0')
94
+ ppt=OUT/(NAME+'.pptx');prs.save(ppt)
95
+ # Render Office for compatibility; retain vector reassembly as the delivery PDF.
96
+ with tempfile.TemporaryDirectory(prefix='wu_vector_slides_') as td:
97
+ td=Path(td);shutil.copy2(ppt,td/'briefing.pptx');res=subprocess.run(['libreoffice','-env:UserInstallation='+(td/'profile').as_uri(),'--headless','--convert-to','pdf','--outdir',str(td),str(td/'briefing.pptx')],capture_output=True,text=True,timeout=90)
98
+ assert res.returncode==0 and (td/'briefing.pdf').exists(),res.stdout+res.stderr
99
+ raw=fitz.open(td/'briefing.pdf');assert len(raw)==len(prs.slides)
100
+ out=fitz.open()
101
+ for i,pg in enumerate(raw):
102
+ out.insert_pdf(raw,from_page=i,to_page=i);target=out[-1]
103
+ # Replace raster fallback regions with direct vector SVG PDFs while retaining
104
+ # native Office text/flowcharts/chart around them.
105
+ for row in [v for v in svg_records if v['slide']==i+1]:
106
+ box=fitz.Rect(row['x']*72,row['y']*72,(row['x']+row['w'])*72,(row['y']+row['h'])*72)
107
+ target.add_redact_annot(box,fill=(1,1,1));target.apply_redactions(images=1,graphics=2);b=cairosvg.svg2pdf(url=str(P/row['source']));vector=fitz.open(stream=b,filetype='pdf');target.show_pdf_page(box,vector,0)
108
+ expected.append(''.join(pg.get_text().split()))
109
+ pdf=OUT/(NAME+'.pdf');out.save(pdf,garbage=4,deflate=True);out.close();raw.close()
110
+ (P/'validation/office_render.log').write_text(res.stdout+res.stderr)
111
+ checks=[]
112
+ with fitz.open(pdf) as doc:
113
+ sheet=Image.new('RGB',(1440,430*((len(doc)+1)//2)),'#e9edf0');draw=ImageDraw.Draw(sheet)
114
+ for i,page in enumerate(doc):
115
+ actual=''.join(page.get_text().split()).replace('−','-')
116
+ missing=[line for value in texts[i] for line in value.split('\n') if ''.join(line.split()).replace('−','-') not in actual]
117
+ assert not missing,(i+1,missing)
118
+ image=page.get_pixmap(matrix=fitz.Matrix(1,1));image.save(OUT/f'briefing_slide_{i+1:02}.png');im=Image.open(OUT/f'briefing_slide_{i+1:02}.png').convert('RGB');im.thumbnail((700,394));sheet.paste(im,((i%2)*720+10,(i//2)*430+5));draw.text(((i%2)*720+10,(i//2)*430+405),str(i+1),fill='black');checks.append(dict(slide=i+1,all_textbox_lines_present=True,raster_images=len(page.get_image_info())))
119
+ sheet.save(P/'validation/slide_contact_sheet.png')
120
+ with zipfile.ZipFile(ppt) as z:
121
+ embedded=[n for n in z.namelist() if n.endswith('.svg')];assert len(embedded)==len(svg_records)
122
+ report=dict(status='PASS',slides=len(prs.slides),embedded_SVG=len(embedded),native_editable_charts=0,native_editable_workflow=True,actual_office_render=True,delivery_PDF='Office text/shapes plus original vector figure recomposition',slide_checks=checks)
123
+ (P/'validation/briefing_validation.json').write_text(json.dumps(report,indent=2)+'\n');(OUT/'slide_content.json').write_text(json.dumps(records,ensure_ascii=False,indent=2)+'\n');print(json.dumps(report))
124
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/code/build_paper.py ADDED
@@ -0,0 +1,160 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Build a reader PDF and a clean, independently compiling Overleaf package."""
2
+ from pathlib import Path
3
+ import re,json,subprocess,shutil,tempfile,zipfile,unicodedata,hashlib
4
+ import fitz
5
+ from journal_layout import records
6
+ P=Path(__file__).resolve().parents[1];R=P.parents[1]
7
+ DOIS=['10.7554/eLife.62576','10.1038/s41467-024-49616-z','10.1038/s41586-024-07763-9','10.1038/s41586-024-07939-3','10.1038/s41586-024-07686-5','10.1016/j.cell.2026.08.015','10.1113/JP288790','10.7554/eLife.56954','10.7554/eLife.77578','10.1038/nn.3547','10.3389/fphys.2026.1898182','10.1016/j.cub.2026.01.014']
8
+ EXT=[('wu_20261105_crossbrain_transfer','crossbrain_transfer'),('wu_20261104_combination_network','anatomical_coverage'),('wu_20261104_combination_network','full_primary_refinement'),('wu_20261105_drive_recurrence','continuous_profiles'),('wu_20261104_public_validation','all21_heldout_traces'),('wu_20261104_public_validation','raw_WT_QC'),('wu_20261104_public_validation','raw_NaChBac_QC'),('wu_20261104_public_validation','native_variants'),('wu_20261104_public_validation','observation_and_calibration'),('wu_20261104_public_validation','published_perturbation_source')]
9
+
10
+ def esc(s):
11
+ trans={'±':r'$\pm$','γ':'gamma','μ':r'$\mu$','µ':r'$\mu$','Ω':r'$\Omega$','−':'-','–':'--','—':'---','×':r'$\times$','≤':r'$\leq$','≥':r'$\geq$','→':r'$\rightarrow$','↓':r'$\downarrow$','’':"'",'‘':"'",'“':'"','”':'"','⁻':'-','⁶':'6','α':r'$\alpha$','Δ':r'$\Delta$','²':'2','³':'3','π':r'$\pi$','…':r'$\ldots$'}
12
+ out=''
13
+ for c in s:
14
+ if c in trans:out+=trans[c]
15
+ else:out+= {'\\':r'\textbackslash{}','&':r'\&','%':r'\%','$':r'\$','#':r'\#','_':r'\_','{':r'\{','}':r'\}','~':r'\textasciitilde{}','^':r'\textasciicircum{}'}.get(c,c)
16
+ return out
17
+
18
+ def inline(s):
19
+ parts=re.split(r'(\[\d+(?:,\d+)*\]|`[^`]+`|https://[^\s]+|\d+(?:\.\d+)? × 10−\d+)',s);out=''
20
+ for t in parts:
21
+ if re.fullmatch(r'\[\d+(?:,\d+)*\]',t):out+=r'\citep{'+','.join('ref'+x for x in t[1:-1].split(','))+'}'
22
+ elif t.startswith('`'):out+=esc(t[1:-1])
23
+ elif t.startswith('https://'):out+=r'\url{'+t+'}'
24
+ elif (scientific:=re.fullmatch(r'(\d+(?:\.\d+)?) × 10−(\d+)',t)):
25
+ out+='$'+scientific[1]+r'\times10^{-'+scientific[2]+'}$'
26
+ else:out+=esc(t)
27
+ return out
28
+
29
+ def compile_at(path,label,basename="main",bibliography=True):
30
+ logs=[]
31
+ commands=[['pdflatex','-interaction=nonstopmode','-halt-on-error',basename+'.tex']]
32
+ if bibliography:commands.append(['bibtex',basename])
33
+ commands += [['pdflatex','-interaction=nonstopmode','-halt-on-error',basename+'.tex']]*2
34
+ for cmd in commands:
35
+ r=subprocess.run(cmd,cwd=path,capture_output=True,text=True,timeout=90);logs.append(r.stdout+r.stderr)
36
+ if r.returncode:raise RuntimeError(' '.join(cmd)+'\n'+logs[-1][-3500:])
37
+ (P/f'validation/{label}_compile.txt').write_text('\n'.join(logs))
38
+ return (path/(basename+'.pdf')).read_bytes(),(path/(basename+'.log')).read_text(errors='replace')
39
+
40
+ def main():
41
+ ref_file=R/'projects/wu_20261104_manuscript_release/metadata/verified_references.json'
42
+ if not ref_file.exists():ref_file=P/'metadata/verified_references.json'
43
+ refs={**json.loads(ref_file.read_text()),**json.loads((P/'metadata/verified_references.json').read_text())};bib=[]
44
+ for i,doi in enumerate(DOIS,1):
45
+ v=refs[doi];author=' and '.join(unicodedata.normalize('NFKD',x).encode('ascii','ignore').decode() for x in v['authors'][:3])+(' and others' if len(v['authors'])>3 else '')
46
+ title=unicodedata.normalize('NFKD',v['title']).encode('ascii','ignore').decode()
47
+ bib.append('@article{ref'+str(i)+',\n author={'+author+'},\n title={{'+title+'}},\n journal={'+v['journal']+'},\n year={'+v['year']+'},\n doi={'+doi+'}\n}')
48
+ (P/'manuscript/references.bib').write_text('\n\n'.join(bib)+'\n')
49
+ (P/'metadata/verified_references.json').write_text(json.dumps({doi:refs[doi] for doi in DOIS},indent=2)+'\n')
50
+ for i,(project,name) in enumerate(EXT,1):
51
+ source_pdf=R/f'projects/{project}/figures/{name}.pdf';target_pdf=P/f'figures/ExtendedData{i}.pdf'
52
+ if source_pdf.exists():shutil.copy2(source_pdf,target_pdf)
53
+ assert target_pdf.exists(),target_pdf
54
+ source=(P/'manuscript/article.md').read_text();title=source.splitlines()[0][2:];abstract=source.split('## Abstract\n\n')[1].split('\n\n## Introduction')[0]
55
+ text=source.split('## Introduction\n\n',1)[1];body=[]
56
+ for line in text.splitlines():
57
+ if line.startswith('## '):
58
+ name=line[3:]
59
+ if name=='Methods':body.append('\\clearpage\n\\onecolumn\n')
60
+ body.append(r'\section*{'+esc(name)+'}')
61
+ elif line.startswith('### '):body.append(r'\subsection*{'+esc(line[4:])+'}')
62
+ elif line:body.append(inline(line)+'\n')
63
+ else:body.append('\n')
64
+ header=r'''\documentclass[10pt,a4paper]{article}
65
+ \usepackage[T1]{fontenc}
66
+ \usepackage[utf8]{inputenc}
67
+ \usepackage{lmodern}
68
+ \usepackage[margin=15mm,columnsep=7mm]{geometry}
69
+ \usepackage{graphicx,microtype,amsmath}
70
+ \usepackage[super,sort&compress]{natbib}
71
+ \usepackage{xurl}
72
+ \usepackage[colorlinks=true,allcolors=black]{hyperref}
73
+ \usepackage{caption}
74
+ \captionsetup{font=small,labelfont=bf}
75
+ \setlength{\parindent}{1em}
76
+ \setlength{\parskip}{0.25em}
77
+ \setlength{\emergencystretch}{1em}
78
+ \makeatletter
79
+ \renewcommand\section{\@startsection{section}{1}{0pt}{2ex plus 1ex}{1ex}{\normalfont\large\bfseries}}
80
+ \renewcommand\subsection{\@startsection{subsection}{2}{0pt}{1.8ex plus .8ex}{.7ex}{\normalfont\normalsize\bfseries}}
81
+ \makeatother
82
+ \begin{document}
83
+ \twocolumn[{
84
+ \begin{center}{\LARGE\bfseries '''+esc(title)+r'''}\par\vspace{3mm}
85
+ {\small 9 November 2026}
86
+ \end{center}
87
+ \noindent\textbf{'''+inline(abstract)+r'''}\par\vspace{6mm}
88
+ }]
89
+ '''
90
+ tex=header+''.join(body)+r'\clearpage\bibliographystyle{unsrtnat}\bibliography{references}'+'\n'
91
+ legends=json.loads((P/'manuscript/legends.json').read_text())
92
+ layout=records();alias=P/'figures/journal';alias.mkdir(exist_ok=True)
93
+ for row in layout:
94
+ for suffix in ['.pdf','.svg']:
95
+ original=P/'figures'/(row['source']+suffix)
96
+ if original.exists():shutil.copy2(original,alias/(row['name']+suffix))
97
+ def figure_tex(row):
98
+ return ('\\clearpage\n\\noindent\\textbf{'+row['label']+'}\n\\begin{center}\n'
99
+ +'\\includegraphics[width=\\textwidth,height=.70\\textheight,keepaspectratio]{../figures/journal/'+row['name']+'.pdf}\n'
100
+ +'\\end{center}\n\\noindent{\\small '+inline(legends[row['source']])+'}\n')
101
+ for row in layout:
102
+ if row['section']!='supplementary':tex+=figure_tex(row)
103
+ supplementary=header.split('\\begin{document}',1)[0]+'\\begin{document}\n\\onecolumn\n'
104
+ supplementary+='\\begin{center}{\\LARGE\\bfseries Supplementary Information}\\par\\vspace{4mm}\n'+esc(title)+'\\end{center}\n'
105
+ supplementary+='\\noindent Supplementary Figures 1--14 preserve complete recording, assay, timing and numerical controls. All original model cells and historical outcomes remain.\n'
106
+ for row in layout:
107
+ if row['section']=='supplementary':supplementary+=figure_tex(row)
108
+ supplementary+='\\end{document}\n'
109
+ (P/'manuscript/supplementary.tex').write_text(supplementary)
110
+ tex+='\\end{document}\n';(P/'manuscript/main.tex').write_text(tex)
111
+ pdf,log=compile_at(P/'manuscript','source');(P/'exports/manuscript.pdf').write_bytes(pdf)
112
+ supp,supplog=compile_at(P/'manuscript','supplementary_source','supplementary',False);(P/'exports/supplementary_information.pdf').write_bytes(supp)
113
+ assert not any(re.search(r'Overfull|undefined|Float too large|LaTeX Warning',line) for line in supplog.splitlines())
114
+ with fitz.open(stream=pdf,filetype='pdf') as combined,fitz.open(stream=supp,filetype='pdf') as sd:
115
+ combined.insert_pdf(sd);combined.save(P/'exports/manuscript_with_supplement.pdf',garbage=4,deflate=True)
116
+ warnings=[line for line in log.splitlines() if re.search(r'Overfull|undefined|Float too large|LaTeX Warning',line)]
117
+ assert not warnings,warnings
118
+ stage=P/'exports/overleaf';
119
+ if stage.exists():shutil.rmtree(stage)
120
+ (stage/'manuscript').mkdir(parents=True);(stage/'figures/journal').mkdir(parents=True)
121
+ for f in ['main.tex','supplementary.tex','references.bib']:shutil.copy2(P/'manuscript'/f,stage/'manuscript'/f)
122
+ for f in sorted((P/'figures/journal').glob('*.pdf')):shutil.copy2(f,stage/'figures/journal'/f.name)
123
+ (stage/'README.txt').write_text('Set manuscript/main.tex as the root document and compile with pdfLaTeX/BibTeX. Set manuscript/supplementary.tex as root for the independent supplementary document (pdfLaTeX). Original SVG artwork and numerical source tables are distributed in the full project release.\n')
124
+ zipfile_path=P/'exports/overleaf_submission.zip'
125
+ with zipfile.ZipFile(zipfile_path,'w',zipfile.ZIP_DEFLATED) as z:
126
+ for f in sorted(stage.rglob('*')):
127
+ if f.is_file():z.write(f,f.relative_to(stage))
128
+ with tempfile.TemporaryDirectory(prefix='wu_paper_replay_') as tmp:
129
+ with zipfile.ZipFile(zipfile_path) as z:z.extractall(tmp)
130
+ replay,replaylog=compile_at(Path(tmp)/'manuscript','extracted_package')
131
+ assert not any(re.search(r'Overfull|undefined|Float too large|LaTeX Warning',l) for l in replaylog.splitlines())
132
+ replay_supp,replay_supp_log=compile_at(Path(tmp)/'manuscript','supplementary_extracted','supplementary',False)
133
+ assert not any(re.search(r'Overfull|undefined|Float too large|LaTeX Warning',line) for line in replay_supp_log.splitlines())
134
+ with fitz.open(stream=replay_supp,filetype='pdf') as a,fitz.open(stream=supp,filetype='pdf') as b:
135
+ assert len(a)==len(b) and [page.get_text() for page in a]==[page.get_text() for page in b]
136
+ with fitz.open(stream=replay,filetype='pdf') as a,fitz.open(stream=pdf,filetype='pdf') as b:
137
+ assert len(a)==len(b)
138
+ assert [p.get_text() for p in a]==[p.get_text() for p in b]
139
+ with fitz.open(stream=pdf,filetype='pdf') as doc:
140
+ full=' '.join(page.get_text() for page in doc)
141
+ for marker in ['5,177','559','35.216','32.723','15.820','14.192','95.4852']:assert marker in full,marker
142
+ assert not re.search(r'/unify/|/tmp/|/root/',full)
143
+ for stale in (P/'validation').glob('paper_page_*.png'):stale.unlink()
144
+ for i in sorted(set([0,1,2]+[j for j,p in enumerate(doc) if p.get_text().startswith('Figure ') or any(p.get_text().startswith('Extended Data Figure '+str(n)) for n in [6,7,8,9,10])])):doc[i].get_pixmap(matrix=fitz.Matrix(1.25,1.25)).save(P/f'validation/paper_page_{i+1:02}.png')
145
+ report=dict(status='PASS',pages=len(doc),main_figures=6,extended_figures=10,supplementary_figures=14,supplementary_pages=len(fitz.open(stream=supp,filetype='pdf')),combined_pages=len(fitz.open(stream=pdf,filetype='pdf'))+len(fitz.open(stream=supp,filetype='pdf')),main_text_words=len(source.split('## Introduction\n\n')[1].split('## Methods')[0].split()),abstract_words=len(abstract.split()),separate_bibliography=True,verified_references=12,overleaf_extracted_compile=True,overleaf_text_identical=True,supplementary_extracted_compile=True,supplementary_text_identical=True,latex_warnings=warnings,visible_local_paths=False,authors_not_inferred=True,main_figure_raster_images=sum(len(fitz.open(P/f'figures/Figure{i}.pdf')[0].get_images()) for i in range(1,7)))
146
+ with fitz.open(stream=pdf,filetype='pdf') as doc:
147
+ inherited=[]
148
+ for i,page in enumerate(doc):
149
+ images=page.get_image_info()
150
+ if images:
151
+ label=page.get_text().splitlines()[0];assert label in ['Extended Data Figure 2','Extended Data Figure 4'],label
152
+ inherited.append(dict(page=i+1,label=label,images=[dict(width=im['width'],height=im['height']) for im in images]))
153
+ inventory=dict(status='DOCUMENTED',main_figure_rasters=0,new_extended_rasters=0,inherited_extended_objects=inherited)
154
+ (P/'validation/inherited_raster_inventory.json').write_text(json.dumps(inventory,indent=2)+'\n')
155
+ with fitz.open(stream=supp,filetype='pdf') as sd:
156
+ assert not re.search(r'/unify/|/tmp/|/root/',' '.join(page.get_text() for page in sd))
157
+ assert all(not page.get_image_info() for page in sd)
158
+ report['all_supplementary_pages_vector']=True
159
+ (P/'validation/manuscript_validation.json').write_text(json.dumps(report,indent=2)+'\n');print(json.dumps(report))
160
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/code/build_reader_docs.py ADDED
@@ -0,0 +1,103 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Write the collaborator entry points from the canonical tables."""
2
+ from pathlib import Path
3
+ import json,pandas as pd,zipfile
4
+ P=Path(__file__).resolve().parents[1]
5
+ def table(df,cols):
6
+ rows=['| '+' | '.join(cols)+' |','| '+' | '.join(['---']*len(cols))+' |']
7
+ for _,r in df.iterrows():rows.append('| '+' | '.join(str(r[k]).replace('|',' / ') for k in cols)+' |')
8
+ return '\n'.join(rows)
9
+ def main():
10
+ c=pd.read_csv(P/'data/class_dictionary.csv');s=json.loads((P/'metadata/atlas_summary.json').read_text());m=pd.read_parquet(P/'data/all_class_memberships.parquet');ns=pd.read_csv(P/'data/namespace_dictionary.csv')
11
+ ns['scope_note_cn']=ns.namespace.map(lambda x:'仅原61细胞;其余细胞在该分析范围之外' if (x=='original61' or x.startswith('focal61_') or 'spatial_explanation' in x) else '见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能')
12
+ ns.to_csv(P/'data/namespace_dictionary.csv',index=False)
13
+ readme=f'''# 全量KC分类、原始数据与吴老师组会汇报(2026-11-09)
14
+
15
+ 本次交付覆盖全部 **5,177 KC**。这是现有分类版本的统一索引与文章后继版,原始32/15/14、旧候选、失败项、未覆盖项和全部历史发布均保留。
16
+
17
+ ## 师弟从这里开始
18
+
19
+ 1. 打开 `exports/KC_all_classifications_5177.xlsx`。`KC5177` 是全细胞主表;`class_dictionary` 逐类解释;`finest20`、`stable8` 与 `original61` 为常用入口。
20
+ 2. 下载 `exports/KC_all_classifications_handoff.zip`,里面有全部 **{s['dictionary_classes']:,} 个方法版本类别条目**的 CSV/TXT 名单,共 {s['per_class_root_files']:,} 份名单文件。用 `member_list_index.csv` 对照短文件名 CL00001 与 `namespace::label`。这些条目包含不同方法、K、种子和残余角色,**不是 {s['dictionary_classes']:,} 种生物类型**。
21
+ 3. `data/KC5177_master.csv` / Parquet:每个KC的18位root_id、坐标、原始已知类型、52候选、8稳定、尺度单元、20最细、原61和全部23次全体KC重跑标签;其余内部细分在长表 `all_class_memberships`。
22
+ 4. `data/class_dictionary.csv`:每类的大小、来源/尺度、证据状态、主导已知细类×侧别、纯度、覆盖率、坐标质心、前三非KC上下游伙伴、输入家族和MBON输出比例、含义与建议分析。完整方向伙伴计数在 `all_class_partner_fingerprints.parquet`。
23
+ 5. `exports/KC_atlas_browser.html` 是不联网的可搜索分类浏览器,可直接复制/下载每类完整ID列表。
24
+ 6. 需要真实树、突触坐标或重跑:下载本前缀 `raw/` 两个完整包,或运行 `python code/download_data.py --out downloaded_data`。不要只拿名单当作原始数据。
25
+
26
+ 所有root_id都是**字符串**。Python读取CSV使用 `pd.read_csv(..., dtype={{'root_id':str}})`,不要经过浮点数;Excel已经写成文本。
27
+
28
+ ## 分类层级
29
+
30
+ - 12种已有解剖细类:来自 source_hemibrain_type;与原始 official_KC_subtype 一并保留。
31
+ - 52个历史候选构成完整分区。证据状态为 stable_main 965 / coverage_fail 344 / tentative 2,207 / unresolved 1,661 个细胞。
32
+ - 8个跨尺度稳定结构候选覆盖965 KC;9个跨方法共识视图仅作描述,不能再相加算新细胞。
33
+ - 40个选中尺度单元中34确认、6未确认。34的并集2,505;保留全部嵌套、逐尺度判决与失败记录。
34
+ - 20个最细非重叠单元覆盖2,125,另外3,052仍保留。10个纯属同细类×侧别,2个完整恢复KCab-p类型×侧别,最低主导细类纯度67.3%。
35
+ - 全体KC重跑有23次,覆盖4种主表征、K20/40/80/160、初始化与网格敏感性。K80只是预定展示,不是最优功能分类数。
36
+ - 另含3种已知父类型内细分、30次61局部重拟合和历史方法。命名必须带namespace;相同C0在不同方法下没有同一身份。
37
+
38
+ `namespace_dictionary.csv` 提供每个视图覆盖与重叠计数。原61和focal61只分析该61细胞,其余5,116处于范围之外;不能把它们解释成“没分清的细胞”。算法稳定不等于独立功能验证。
39
+
40
+ ## 完整原始数据与版本
41
+
42
+ 本前缀 raw/:
43
+
44
+ - `KC_all5177_complete_structural_atlas_20261030.zip`:570,888,101字节,5,301成员,全部5,177个geometry对象,以及KC相关突触、2,261,016端点、有向连接、分支、伙伴注释、分析、代码和审计。
45
+ - `KC_classification_full_sources.zip`:452,747,698字节,32,203原始源文件,含640次多尺度划分、发现/确认标签、协议、完整联合表征、全部拟合、历史对照和原组会纪要。
46
+
47
+ 以上是FlyWire v783 **KC相关子集**,不是把全脑原始电镜发布为本项目数据。每包SHA256见 `metadata/raw_archives.json`,下载脚本校验大小与哈希。包内原始目录结构保留,解压至同一工作目录后即可按原路径访问;代码需pandas/numpy/scipy/pyarrow/scikit-learn/xlsxwriter/openpyxl。
48
+
49
+ 已有全量模拟轨迹和其他公开源对象在 `data/previous_public_data_objects.json` 按不可变HF revision列出(3,271项,约19.7 GB),包含原始/交换时序、全部主/细网格KC与MBON电位、事件、参数、公开生理和跨脑结果。默认下载脚本只取本次两个完整原始包;`--all-historical`再下载历史对象。历史目录中的资料是来源与重放记录,不是本轮新增实验。
50
+
51
+ ## 关键分母与生物对应
52
+
53
+ - `type_side_purity = 主导已知细类×侧别命中数 / 类成员数`。
54
+ - `dominant_parent_coverage = 命中数 / 该已知细类×侧别全部细胞数`。不是功能准确率。
55
+ - 新指纹的输入分母是全部输入端点,输出分母是全部输出端点,包括KC与未注释伙伴;不同于旧多尺度表的external-only分母。前三伙伴筛掉KC,但给的是计数;完整端点比例仍以全方向为分母。
56
+ - `source_hemibrain_type`细分KCab-s/m/c,不能用粗KCab的分母解释细类型覆盖。
57
+ - 一条ap1原始official标签使用未归一化别名;source细类映射将它保留为ap1。因此新CM020细类表为122/133,旧按归一化official字段为121/132。旧entry表原样保留,差异是口径,不是改了成员。
58
+ - ALPN主要关联嗅觉通路,direct VPN为直接视觉投射,APL为反馈来源,MBON为输出;L为模型操作性间接视觉候选,不能把这些都叫“视觉输入”或用比例直接命名新功能类型。
59
+
60
+ ## 查询与复现
61
+
62
+ ```bash
63
+ python code/query_class.py --namespace finest20 --label SU035 --out SU035_cells.csv
64
+ python code/query_class.py --namespace original61 --label abp_R_K3_C2 --out original14.csv
65
+ python code/query_class.py --root-id 720575940606579465
66
+ python code/build_atlas.py
67
+ python code/build_atlas_figures.py
68
+ python code/build_briefing.py
69
+ python code/update_article.py
70
+ python code/build_paper.py
71
+ ```
72
+
73
+ 构建输入见 `metadata/source_manifest.json`;将本项目置于projects/下,运行 `python code/unpack_raw.py /path/to/KC_all5177_complete_structural_atlas_20261030.zip /path/to/KC_classification_full_sources.zip` 映射两个压缩包的目录布局,即可重建。原61与仿真顺序源表已包含在本项目data/中。原始动力学图保留在本目录;其科学源表与重放代码来自不可变前序发布。本文包的独立重放针对分类整合、图谱图和Overleaf编译;没有重新运行历史全部模拟或湿实验。
74
+
75
+ ## 汇报与文章
76
+
77
+ `exports/吴老师汇报_全量KC分类与网络计算_12页_20261109.pptx`:12页,可编辑文字并嵌SVG,逐页中文讲稿见 `exports/逐页讲稿.md`;PDF直接保留矢量。文章见 `exports/manuscript.pdf`,SI见 `exports/supplementary_information.pdf`,Overleaf包已独立解压编译。
78
+
79
+ 论文主线:真实网络中循环传递把局部启动扩展为群体募集,输入时间组织和树上时序分配进一步改变累积。主/细网格中全部六组交换效应非零,但两组反向,方向/幅度需继续检查;公开生理限定固定参数迁移范围。结构图谱先整理已知对应,混合与未解释部分作为明确问题保留。
80
+
81
+ ## 署名、来源和使用条件
82
+
83
+ Git作者:ydchen0806 <yindachen@mail.ustc.edu.cn>。未推定论文作者顺序。真实脑/蘑菇体矢量素材来自FlyWire Consortium / Amy Sterling gallery的固定版本,归属与CC BY-NC 4.0来源说明见 `metadata/mesh_source_attribution.json`。第三方数据分别保留其来源使用条件;不对全部组件宣称统一许可证。文章是按Nature研究论文结构组织的当前稿件,发表层级取决于最终证据与评审。
84
+ '''
85
+ (P/'README.md').write_text(readme)
86
+ fine=c[c.namespace.eq('finest20')][['label','n_cells','dominant_known_fine_type','dominant_side','type_side_purity','dominant_parent_coverage','correspondence_cn','in_top3_nonKC_partner_counts','out_top3_nonKC_partner_counts']].copy()
87
+ doc='# 每类是什么意思:生物对应与分析入口\n\n每个方法版本类别的完整说明均在Excel/CSV中。本文件先给最常用层级。\n\n## 已有解剖细类\n\n'
88
+ anatomy=c[c.namespace.eq('known_fine_anatomy')][['label','n_cells','biological_context_cn']]
89
+ doc+=table(anatomy,list(anatomy.columns))+'\n\n## 稳定8候选\n\n'
90
+ st=c[c.namespace.eq('stable8')][['label','n_cells','dominant_known_fine_type','dominant_side','type_side_purity','dominant_parent_coverage','correspondence_cn']]
91
+ doc+=table(st,list(st.columns))+'\n\n## 最细20单元:逐类对应与主要非KC伙伴\n\n'+table(fine,list(fine.columns))+'\n\n输入/输出top3为非KC伙伴计数,不是功能标签。全部4038条目还包括不同K/方法/种子、父类内细分、旧对照和残余;请用class_dictionary按namespace检索。所有类别均可从member_list_index找到CSV/TXT。\n'
92
+ (P/'类别说明与分析入口.md').write_text(doc)
93
+ notes=json.loads((P/'exports/slide_content.json').read_text());(P/'exports/逐页讲稿.md').write_text('# 吴老师组会:12页逐页讲稿\n\n'+'\n\n'.join(f"## {i+1:02} {r['title']}\n\n**结论:{r['summary']}**\n\n{r['notes']}" for i,r in enumerate(notes)))
94
+ # Browser: self-contained classifications with exact text root IDs and downloads.
95
+ records=[];roots=m.groupby('class_key').root_id.agg(list).to_dict()
96
+ for row in c.fillna('').to_dict('records'):row['roots']=roots[row['class_key']];records.append(row)
97
+ payload=json.dumps(records,ensure_ascii=False,separators=(',',':')).replace('</','<\\/')
98
+ html='''<!doctype html><meta charset="utf-8"><title>KC全量分类图谱</title><style>body{font:16px system-ui;color:#243746;margin:32px;max-width:1500px}h1{font-size:27px}input,select,button{padding:10px;font:inherit;margin:5px}table{border-collapse:collapse;width:100%;font-size:14px}td,th{border-bottom:1px solid #ddd;padding:8px;text-align:left}tr:hover{background:#eaf3f3;cursor:pointer}#detail{white-space:pre-wrap;background:#f2f6f6;padding:16px}textarea{width:95%;height:150px}small{color:#556b75}</style><h1>全部5,177 KC:分类、含义与逐类名单</h1><p>4038个方法版本条目;包含不同K、种子和残余,并非4038种生物类型。点击一类查看完整ID。离线运行。</p><select id="ns"></select><input id="q" placeholder="搜索标签、已知类型或说明"><span id="count"></span><div id="detail">选择下方任意类别。</div><table><thead><tr><th>namespace</th><th>类别</th><th>n</th><th>主导已知细类</th><th>侧别</th><th>纯度</th><th>覆盖</th><th>状态</th></tr></thead><tbody id="rows"></tbody></table><script>const data=PAYLOAD;const ns=document.querySelector('#ns'),q=document.querySelector('#q'),rows=document.querySelector('#rows'),detail=document.querySelector('#detail');const option=(s)=>{let o=document.createElement('option');o.textContent=s;ns.append(o)};option('finest20');[...new Set(data.map(x=>x.namespace))].filter(x=>x!='finest20').forEach(option);let selected;function render(){rows.replaceChildren();let subset=data.filter(r=>r.namespace==ns.value&&JSON.stringify(r).toLowerCase().includes(q.value.toLowerCase()));document.querySelector('#count').textContent=subset.length+'类';subset.forEach(r=>{let tr=document.createElement('tr');[r.namespace,r.label,r.n_cells,r.dominant_known_fine_type,r.dominant_side,(100*r.type_side_purity).toFixed(1)+'%',(100*r.dominant_parent_coverage).toFixed(1)+'%',r.evidence_status].forEach(v=>{let td=document.createElement('td');td.textContent=v;tr.append(td)});tr.onclick=()=>show(r);rows.append(tr)})}function show(r){selected=r;detail.replaceChildren();let p=document.createElement('p');p.textContent=r.class_key+' | n='+r.n_cells+'\n'+r.meaning_cn+'\n'+r.biological_context_cn+';'+r.correspondence_cn+'\n主要非KC输入计数:'+r.in_top3_nonKC_partner_counts+'\n主要非KC输出计数:'+r.out_top3_nonKC_partner_counts+'\n'+r.recommended_analysis_cn;detail.append(p);let a=document.createElement('button');a.textContent='下载本类root_id.txt';a.onclick=()=>{let link=document.createElement('a');link.href=URL.createObjectURL(new Blob([r.roots.join('\\n')+'\\n'],{type:'text/plain;charset=utf-8'}));link.download='KC_'+r.label.replace(/[^a-zA-Z0-9_-]/g,'_')+'.txt';link.click();setTimeout(()=>URL.revokeObjectURL(link.href),1000)};detail.append(a);let area=document.createElement('textarea');area.value=r.roots.join('\\n');area.readOnly=true;detail.append(area)}ns.onchange=render;q.oninput=render;render();</script>'''.replace('PAYLOAD',payload)
99
+ # Convert intended JS newlines to escaped literals (the HTML source is not shell text).
100
+ html=html.replace("+'\n'+","+'\\n'+").replace("+'\n主要","+'\\n主要").replace("+'\n'+r.","+'\\n'+r.")
101
+ (P/'exports/KC_atlas_browser.html').write_text(html)
102
+ print('Collaborator README, biological dictionary, slide notes and offline browser generated.')
103
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/code/download_data.py ADDED
@@ -0,0 +1,27 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Download the complete raw KC subset and classification replay sources.
2
+ Default: two complete current raw archives (~1.02 GB). Optionally materialize
3
+ all previous publicly archived objects (~19.7 GB), pinned to their revisions.
4
+ Read the provenance/license notes before reuse; no single blanket licence.
5
+ """
6
+ from pathlib import Path
7
+ import argparse,json,hashlib
8
+ from huggingface_hub import hf_hub_download
9
+ P=Path(__file__).resolve().parents[1];REPO='cyd0806/neuronmimic-data'
10
+ def digest(path):
11
+ h=hashlib.sha256()
12
+ with open(path,'rb') as f:
13
+ for chunk in iter(lambda:f.read(8*1024*1024),b''):h.update(chunk)
14
+ return h.hexdigest()
15
+ def main():
16
+ ap=argparse.ArgumentParser();ap.add_argument('--out',type=Path,default=Path('downloaded_data'));ap.add_argument('--all-historical',action='store_true');a=ap.parse_args()
17
+ receipt_path=P/'metadata/publication_receipt.json'
18
+ if not receipt_path.exists():receipt_path=Path(hf_hub_download(REPO,'wu_20261109_full_atlas_briefing/metadata/publication_receipt.json',repo_type='dataset'))
19
+ receipt=json.loads(receipt_path.read_text());rev=receipt['payload_commit']
20
+ for row in json.loads((P/'metadata/raw_archives.json').read_text()):
21
+ f=hf_hub_download(REPO,'wu_20261109_full_atlas_briefing/'+row['path'],repo_type='dataset',revision=rev,local_dir=a.out)
22
+ assert Path(f).stat().st_size==row['bytes'] and digest(f)==row['sha256'];print('Verified',row['path'])
23
+ if a.all_historical:
24
+ for row in json.loads((P/'data/previous_public_data_objects.json').read_text()):
25
+ f=hf_hub_download(REPO,row['path'],repo_type='dataset',revision=row['revision'],local_dir=a.out);assert Path(f).stat().st_size==row['size']
26
+ print('Previous immutable objects downloaded; HF validates transport blobs and LFS content.')
27
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/code/final_checks.py ADDED
@@ -0,0 +1,22 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ from pathlib import Path
2
+ import hashlib,json,zipfile,pandas as pd,openpyxl
3
+ P=Path(__file__).resolve().parents[1]
4
+ def main():
5
+ c=pd.read_parquet(P/'data/KC5177_master.parquet');m=pd.read_parquet(P/'data/all_class_memberships.parquet');d=pd.read_csv(P/'data/class_dictionary.csv');summary=json.loads((P/'metadata/atlas_summary.json').read_text())
6
+ assert len(c)==c.root_id.nunique()==5177
7
+ assert c.root_id.map(lambda s:isinstance(s,str) and s.isdecimal() and len(s)==18).all()
8
+ sim=c[c.simulation_gid.ne('')].copy();assert len(sim)==32 and sorted(sim.simulation_gid.astype(int))==list(range(32));assert sim.original61.eq('abp_R_K3_C0').all()
9
+ assert c.finest20.eq('UNASSIGNED').sum()==3052
10
+ assert d.class_key.nunique()==4038 and len(m)==230899
11
+ assert m.groupby('class_key').size().reindex(d.class_key).to_numpy().tolist()==d.n_cells.tolist()
12
+ raw=json.loads((P/'metadata/raw_archives.json').read_text());assert sum(x['bytes'] for x in raw)==1023635799
13
+ for name in ['atlas_validation','isolated_atlas_replay','briefing_validation','manuscript_validation','browser_logic_check']:
14
+ assert json.loads((P/'validation'/f'{name}.json').read_text())['status']=='PASS'
15
+ w=openpyxl.load_workbook(P/'exports/KC_all_classifications_5177.xlsx',read_only=True);rows=w['KC5177'].iter_rows();heads=[x.value for x in next(rows)];ix=heads.index('root_id');ids=[r[ix] for r in rows];assert all(x.data_type=='s' for x in ids);assert [x.value for x in ids]==c.root_id.tolist()
16
+ with zipfile.ZipFile(P/'exports/KC_all_classifications_handoff.zip') as z:
17
+ assert z.testzip() is None and sum(n.startswith('member_lists/') for n in z.namelist())==8076
18
+ assert z.read('data/class_dictionary.csv')==(P/'data/class_dictionary.csv').read_bytes()
19
+ assert z.read('KC_all_classifications_5177.xlsx')==(P/'exports/KC_all_classifications_5177.xlsx').read_bytes()
20
+ report=dict(status='PASS',all_5177_cells_retained=True,all_namespace_memberships_conserved=True,simulation_order_original32=True,all_8076_lists_packaged=True,Excel_ID_text_after_final_seal=True,raw_archives_bytes=sum(x['bytes'] for x in raw),classification_replay_byte_identical=True,article_and_slides_checked=True)
21
+ (P/'validation/final_checks.json').write_text(json.dumps(report,indent=2)+'\n');print(json.dumps(report))
22
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/code/journal_layout.py ADDED
@@ -0,0 +1,38 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Keep six main figures, ten Extended Data figures and full supplementary art."""
2
+ import re
3
+
4
+ EXTENDED=[1,2,3,4,5,13,15,16,22,23]
5
+ SUPPLEMENTARY=[i for i in range(1,25) if i not in EXTENDED]
6
+
7
+ def records():
8
+ rows=[dict(source=f'Figure{i}',name=f'Figure{i}',section='main',label=f'Figure {i}') for i in range(1,7)]
9
+ rows += [dict(source=f'ExtendedData{old}',name=f'ExtendedData{i}',section='extended',
10
+ label=f'Extended Data Figure {i}') for i,old in enumerate(EXTENDED,1)]
11
+ rows += [dict(source=f'ExtendedData{old}',name=f'SupplementaryFigure{i}',section='supplementary',
12
+ label=f'Supplementary Figure {i}') for i,old in enumerate(SUPPLEMENTARY,1)]
13
+ return rows
14
+
15
+ def convert_citations(text):
16
+ mapping={old:('Extended Data',i) for i,old in enumerate(EXTENDED,1)}
17
+ mapping.update({old:('Supplementary',i) for i,old in enumerate(SUPPLEMENTARY,1)})
18
+ component=r'\d+(?:[a-z](?:[–-][a-z])?)?(?:\s*[–-]\s*\d+[a-z]?)?'
19
+ pattern=re.compile(r'Extended Data Figs?\.\s*'+component+r'(?:(?:,\s*| and )(?:'+component+r'|[a-z]))*')
20
+ def replace(match):
21
+ content=re.sub(r'^Extended Data Figs?\.\s*','',match.group())
22
+ # Expand numerical ranges before preserving panel-letter groups.
23
+ content=re.sub(r'(\d+)\s*[–-]\s*(\d+)',lambda m:', '.join(str(i) for i in range(int(m[1]),int(m[2])+1)),content)
24
+ parts=re.findall(r'(\d+)([a-z](?:[–-][a-z])?(?:,\s*[a-z])*)?',content)
25
+ groups=[]
26
+ for old,suffix in parts:
27
+ family,n=mapping[int(old)]
28
+ ref=str(n)+suffix.replace(' ','')
29
+ if groups and groups[-1][0]==family:
30
+ groups[-1][1].append(ref)
31
+ else:
32
+ groups.append((family,[ref]))
33
+ formatted=[]
34
+ for family,refs in groups:
35
+ values=', '.join(refs[:-1])+' and '+refs[-1] if len(refs)>1 else refs[0]
36
+ formatted.append(family+(' Figs. ' if len(refs)>1 else ' Fig. ')+values)
37
+ return ' and '.join(formatted)
38
+ return pattern.sub(replace,text)
wu_20261109_full_atlas_briefing/code/package_raw.py ADDED
@@ -0,0 +1,38 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Archive all raw KC atlas objects and all classification replay sources.
2
+ Large archives are published to HF, not committed to GitHub.
3
+ """
4
+ from pathlib import Path
5
+ import json,hashlib,zipfile,shutil
6
+ from build_atlas import sha,P,R
7
+ OUT=R/'deliveries/wu_20261109_full_atlas_raw'
8
+ def main():
9
+ OUT.mkdir(exist_ok=True)
10
+ archive=R/'deliveries/kc_all5177_structural_atlas_20261030/KC_all5177_complete_structural_atlas_20261030.zip'
11
+ with zipfile.ZipFile(archive) as z:
12
+ assert z.testzip() is None
13
+ names=z.namelist();geom=[n for n in names if '/geometry/' in n and n.endswith('.json')];assert len(geom)==5177,len(geom)
14
+ raw=dict(local=str(archive.relative_to(R)),path='raw/'+archive.name,bytes=archive.stat().st_size,sha256=sha(archive),archive_members=len(names),geometry_objects=len(geom),scope='All 5177 KC geometry, incident synapses, endpoints, directed pairs, branch profiles, annotations, analysis, source and audits; FlyWire v783 subset.')
15
+ paths=[R/'artifacts/wu_20261026_multiscale_units',R/'artifacts/wu_20261030_fine_units_integrated_atlas',R/'projects/wu_20261102_followup_20261103']
16
+ paths += [p for p in sorted((R/'artifacts').glob('*')) if p.name in ['wu_20261026_density_refinement','wu_20261027_branch_contact_model','wu_20261027_local_tree_refinement','wu_20261028_open_tools','wu_20261028_parent_free_model']]
17
+ paths += [R/'artifacts/nature_kc_20261102/spatial_explanation_v1']
18
+ target=OUT/'KC_classification_full_sources.zip';manifest=[]
19
+ with zipfile.ZipFile(target,'w',zipfile.ZIP_DEFLATED) as z:
20
+ for base in paths:
21
+ for f in sorted(base.rglob('*')):
22
+ if f.is_file() and '__pycache__' not in f.parts:
23
+ z.write(f,str(f.relative_to(R)));manifest.append(dict(path=str(f.relative_to(R)),bytes=f.stat().st_size,sha256=sha(f)))
24
+ for f in [R/'simulation/scripts/build_fine_units_integrated_atlas.py',R/'20261102_吴老师组会纪要.pdf']:
25
+ z.write(f,str(f.relative_to(R)));manifest.append(dict(path=str(f.relative_to(R)),bytes=f.stat().st_size,sha256=sha(f)))
26
+ z.writestr('SOURCE_FILE_MANIFEST.json',json.dumps(manifest,ensure_ascii=False,indent=2))
27
+ with zipfile.ZipFile(target) as z:assert z.testzip() is None
28
+ second=dict(local=str(target.relative_to(R)),path='raw/'+target.name,bytes=target.stat().st_size,sha256=sha(target),source_files=len(manifest),scope='Complete multiscale discovery/confirmation labels and protocols, full joint features and assignments, all parent/focal refits, integrated finest atlas, historical method controls and source scripts.')
29
+ (P/'metadata/raw_archives.json').write_text(json.dumps([raw,second],ensure_ascii=False,indent=2)+'\n')
30
+ # Every existing remote object is indexed with an immutable revision for full historical replay.
31
+ inv=json.load(open('/tmp/wu_hf_inventory.json'));rows=[]
32
+ for f in inv['files']:
33
+ if f['path']=='.gitattributes':continue
34
+ if f['path'].split('/')[0].startswith(('wu_','structure_','flywire_','p1','p0','physics_','provenance')):
35
+ rows.append(dict(**f,revision=inv['revision'],url=f"https://huggingface.co/datasets/cyd0806/neuronmimic-data/resolve/{inv['revision']}/{f['path']}"))
36
+ (P/'data/previous_public_data_objects.json').write_text(json.dumps(rows,ensure_ascii=False,indent=2)+'\n')
37
+ print(json.dumps(dict(raw_archives=[raw,second],previous_objects_indexed=len(rows),previous_bytes=sum(x['size'] for x in rows)),ensure_ascii=False,indent=2))
38
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/code/publish_release.py ADDED
@@ -0,0 +1,68 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Additive publication of the reviewed atlas, article and 12-slide briefing.
2
+ GitHub receives code and compact reviewable data. HF also receives both full
3
+ raw archives. No old prefix is overwritten; each remote object is verified.
4
+ """
5
+ from pathlib import Path
6
+ import hashlib,json,re,subprocess
7
+ import httpx
8
+ from huggingface_hub import HfApi,CommitOperationAdd,set_client_factory
9
+ P=Path(__file__).resolve().parents[1];R=P.parents[1];W=R/'deliveries/wu_structure_function_code_20261105'
10
+ REPO='cyd0806/neuronmimic-data';PREFIX=P.name
11
+
12
+ def files():
13
+ return [f for f in sorted(P.rglob('*')) if f.is_file() and '__pycache__' not in f.parts and f.name!='publication_receipt.json' and not f.is_relative_to(P/'exports/overleaf') and f.suffix not in ['.aux','.bbl','.blg','.log','.out']]
14
+ def identity(obj):return obj.size,obj.blob_id,getattr(getattr(obj,'lfs',None),'sha256',None)
15
+ def sha(p):
16
+ h=hashlib.sha256()
17
+ with p.open('rb') as f:
18
+ for b in iter(lambda:f.read(8*1024*1024),b''):h.update(b)
19
+ return h.hexdigest()
20
+ def main():
21
+ for f in ['atlas_validation.json','isolated_atlas_replay.json','briefing_validation.json','manuscript_validation.json','final_checks.json']:
22
+ assert json.loads((P/'validation'/f).read_text())['status']=='PASS',f
23
+ assert json.loads((P/'validation/visual_review.json').read_text())['status']=='PASS'
24
+ head=subprocess.check_output(['git','rev-parse','HEAD'],cwd=W,text=True).strip()
25
+ remote=subprocess.check_output(['git','ls-remote','origin','refs/heads/research/wu-structure-function-20261104'],cwd=W,text=True).split()[0]
26
+ assert head==remote and not subprocess.check_output(['git','status','--porcelain','-z'],cwd=W)
27
+ payload=files();pat=re.compile(rb'(?:gh[pousr]_[A-Za-z0-9_]{20,}|github_pat_[A-Za-z0-9_]{20,}|hf_[A-Za-z0-9]{20,})')
28
+ tracked=set(subprocess.check_output(['git','ls-files','-z'],cwd=W,text=True).split('\0'))
29
+ for f in payload:
30
+ assert not pat.search(f.read_bytes()),f.name
31
+ path='projects/'+P.name+'/'+str(f.relative_to(P));assert path in tracked,path
32
+ assert (W/path).read_bytes()==f.read_bytes(),path
33
+ for line in (P/'SHA256SUMS').read_text().splitlines():
34
+ d,n=line.split(' ',1);assert sha(P/n)==d,n
35
+ proxy=subprocess.run(['git','config','--get','https.proxy'],capture_output=True,text=True).stdout.strip()
36
+ set_client_factory(lambda:httpx.Client(proxy=proxy or None,timeout=120,follow_redirects=True))
37
+ api=HfApi();assert api.whoami()['name']=='cyd0806'
38
+ before=api.repo_info(REPO,repo_type='dataset').sha
39
+ old={o.path:identity(o) for o in api.list_repo_tree(REPO,repo_type='dataset',revision=before,recursive=True) if hasattr(o,'size')}
40
+ assert not any(n.startswith(PREFIX+'/') for n in old)
41
+ items=[(str(f.relative_to(P)),f) for f in payload]
42
+ for row in json.loads((P/'metadata/raw_archives.json').read_text()):
43
+ f=R/row['local'];assert f.stat().st_size==row['bytes'] and sha(f)==row['sha256'];items.append((row['path'],f))
44
+ operations=[CommitOperationAdd(path_in_repo=PREFIX+'/'+name,path_or_fileobj=f) for name,f in items]
45
+ print('Publishing',len(items),'objects;',sum(f.stat().st_size for _,f in items),'bytes',flush=True)
46
+ commit=api.create_commit(REPO,repo_type='dataset',parent_commit=before,operations=operations,commit_message='Release all 5177 KC classifications, full raw archives, class dictionary, article and 12-slide Wu briefing',num_threads=4)
47
+ current={o.path:o for o in api.list_repo_tree(REPO,repo_type='dataset',revision=commit.oid,recursive=True) if hasattr(o,'size')}
48
+ checked=[]
49
+ for name,f in items:
50
+ obj=current[PREFIX+'/'+name];digest=sha(f);assert obj.size==f.stat().st_size,name
51
+ if identity(obj)[2]:assert identity(obj)[2]==digest,name
52
+ else:
53
+ b=f.read_bytes();assert obj.blob_id==hashlib.sha1(b'blob '+str(len(b)).encode()+b'\0'+b).hexdigest(),name
54
+ checked.append(dict(path=name,bytes=f.stat().st_size,sha256=digest))
55
+ for name,ident in old.items():
56
+ if name!='.gitattributes':assert identity(current[name])==ident,name
57
+ if '.gitattributes' in old and identity(current['.gitattributes'])!=old['.gitattributes']:
58
+ from huggingface_hub import hf_hub_download
59
+ lines=lambda rev:set(Path(hf_hub_download(REPO,'.gitattributes',repo_type='dataset',revision=rev)).read_text().splitlines())
60
+ assert lines(before)<=lines(commit.oid)
61
+ receipt=dict(status='PUBLISHED_AND_VERIFIED',github_scientific_commit=head,branch='research/wu-structure-function-20261104',dataset=REPO,prefix=PREFIX,payload_commit=commit.oid,previous_dataset_revision=before,historical_objects_preserved=len(old)-int('.gitattributes' in old),summary=json.loads((P/'metadata/atlas_summary.json').read_text()),verified_files=checked)
62
+ body=json.dumps(receipt,ensure_ascii=False,indent=2).encode()
63
+ rec=api.create_commit(REPO,repo_type='dataset',parent_commit=commit.oid,operations=[CommitOperationAdd(path_in_repo=PREFIX+'/metadata/publication_receipt.json',path_or_fileobj=body)],commit_message='Record full atlas release hashes and preserved historical objects')
64
+ obj=api.get_paths_info(REPO,[PREFIX+'/metadata/publication_receipt.json'],repo_type='dataset',revision=rec.oid)[0]
65
+ assert obj.size==len(body) and obj.blob_id==hashlib.sha1(b'blob '+str(len(body)).encode()+b'\0'+body).hexdigest()
66
+ receipt['receipt_commit']=rec.oid;(P/'metadata/publication_receipt.json').write_text(json.dumps(receipt,ensure_ascii=False,indent=2)+'\n')
67
+ print(json.dumps({k:v for k,v in receipt.items() if k not in ['verified_files','summary']},indent=2))
68
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/code/query_class.py ADDED
@@ -0,0 +1,20 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Exact root-ID lookup; no credential or network required.
2
+ Example: python code/query_class.py --namespace finest20 --label SU035
3
+ python code/query_class.py --root-id 720575940606579465
4
+ """
5
+ from pathlib import Path
6
+ import argparse,pandas as pd
7
+ P=Path(__file__).resolve().parents[1]
8
+ def main():
9
+ p=argparse.ArgumentParser();p.add_argument('--namespace');p.add_argument('--label');p.add_argument('--root-id');p.add_argument('--out',type=Path);a=p.parse_args()
10
+ m=pd.read_parquet(P/'data/all_class_memberships.parquet');d=pd.read_csv(P/'data/class_dictionary.csv',dtype={'label':str})
11
+ if a.root_id:
12
+ result=m[m.root_id.eq(a.root_id)].merge(d,on=['class_key','namespace','label'],validate='many_to_one');print(result[['namespace','label','n_cells','evidence_status','dominant_known_fine_type','dominant_side']].to_string(index=False))
13
+ else:
14
+ assert a.namespace,'Choose --root-id OR --namespace [--label]'
15
+ q=m[m.namespace.eq(a.namespace)]
16
+ if a.label:q=q[q.label.eq(a.label)]
17
+ assert len(q),'No matching class. See data/namespace_dictionary.csv and data/class_dictionary.csv'
18
+ result=q.merge(pd.read_parquet(P/'data/KC5177_master.parquet'),on='root_id',validate='many_to_one');print(result[['root_id','label','source_hemibrain_type','official_hemisphere','soma_x_um','soma_y_um','soma_z_um']].to_string(index=False))
19
+ if a.out:result.to_csv(a.out,index=False)
20
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/code/seal_handoff.py ADDED
@@ -0,0 +1,34 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Refresh the portable handoff after final documents and source tables."""
2
+ from pathlib import Path
3
+ import zipfile,shutil,tempfile,json
4
+ from openpyxl import load_workbook
5
+ P=Path(__file__).resolve().parents[1]
6
+ def main():
7
+ x=P/'exports/KC_all_classifications_5177.xlsx';w=load_workbook(x)
8
+ if 'README' in w:del w['README']
9
+ s=w.create_sheet('README',0)
10
+ for row in [
11
+ ['内容','全部5,177 KC;各分类视图并存,详见项目README与类别说明'],
12
+ ['分类条目','4,038为不同方法/K/种子/作用域条目,不是生物类型数'],
13
+ ['root_id','18位文本,不得先转浮点数'],
14
+ ['known_fine','source_hemibrain_type保留细KCab-s/m/c;official原字段另存'],
15
+ ['unassigned','finest20未覆盖仍保留;original61之外为范围外,不是没功能'],
16
+ ['嵌套','34确认单元允许嵌套,不能把成员数相加算唯一细胞'],
17
+ ['比例','输入/输出分别使用全部同方向端点,包括KC接点和未知伙伴'],
18
+ ['完整名单','zip内member_list_index.csv对应8,076份CSV/TXT'],
19
+ ['原始数据','同一HF前缀raw/含完整结构与完整分类重放包'],
20
+ ['仿真编号','simulation_gid仅原32组对应0至31,其他细胞留空'],
21
+ ['功能解释','解剖对应与算法稳定性不能直接当作新的生理功能类型']]:s.append(row)
22
+ s.column_dimensions['A'].width=20;s.column_dimensions['B'].width=115;w.save(x)
23
+ old=P/'exports/KC_all_classifications_handoff.zip';temp=old.with_suffix('.new.zip')
24
+ with zipfile.ZipFile(old) as src,zipfile.ZipFile(temp,'w',zipfile.ZIP_DEFLATED) as out:
25
+ for info in src.infolist():
26
+ if info.filename.startswith('member_lists/') or info.filename=='member_list_index.csv':out.writestr(info.filename,src.read(info))
27
+ for file in sorted((P/'data').glob('*')):out.write(file,'data/'+file.name)
28
+ for file in [P/'README.md',P/'类别说明与分析入口.md',x,P/'metadata/raw_archives.json',P/'metadata/source_manifest.json',P/'metadata/integration_protocol.json']:
29
+ out.write(file,str(file.relative_to(P)) if file!=x else file.name)
30
+ for file in ['query_class.py','download_data.py','unpack_raw.py']:out.write(P/'code'/file,'code/'+file)
31
+ out.write(P/'exports/KC_atlas_browser.html','KC_atlas_browser.html')
32
+ with zipfile.ZipFile(temp) as z:assert z.testzip() is None;count=sum(n.startswith('member_lists/') for n in z.namelist());assert count==8076
33
+ temp.replace(old);print('Sealed portable handoff:',old.stat().st_size,'bytes;',count,'per-class lists')
34
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/code/unpack_raw.py ADDED
@@ -0,0 +1,19 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Map both portable ZIP layouts to the source tree expected by build_atlas.py."""
2
+ from pathlib import Path
3
+ import argparse,zipfile
4
+ P=Path(__file__).resolve().parents[1];R=P.parents[1]
5
+ def main():
6
+ a=argparse.ArgumentParser();a.add_argument('atlas_zip',type=Path);a.add_argument('classification_zip',type=Path);a.add_argument('--root',type=Path,default=R);q=a.parse_args()
7
+ for f,atlas in [(q.atlas_zip,True),(q.classification_zip,False)]:
8
+ with zipfile.ZipFile(f) as z:
9
+ for name in z.namelist():
10
+ if name.endswith('/'):continue
11
+ relative=Path(*Path(name).parts[1:]) if atlas else Path(name)
12
+ if atlas:relative=Path('artifacts/wu_20261030_all5177_structural_atlas')/relative
13
+ dest=q.root/relative
14
+ assert dest.resolve().is_relative_to(q.root.resolve()),'Unsafe archive path'
15
+ dest.parent.mkdir(parents=True,exist_ok=True)
16
+ with z.open(name) as src,dest.open('wb') as out:
17
+ import shutil;shutil.copyfileobj(src,out)
18
+ print('Raw sources arranged at',q.root)
19
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/code/update_article.py ADDED
@@ -0,0 +1,37 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Create an atlas-integrated article successor without modifying frozen studies."""
2
+ from pathlib import Path
3
+ import json,shutil
4
+ P=Path(__file__).resolve().parents[1];R=P.parents[1];A=R/'projects/wu_20261108_active_refinement'
5
+ def main():
6
+ summary=json.loads((P/'metadata/atlas_summary.json').read_text())
7
+ s=(A/'manuscript/article.md').read_text()
8
+ marker='We evaluated whether joint partner identity–position features improve prediction'
9
+ paragraph="""A complete classification crosswalk places these objects in a common anatomical hierarchy (Supplementary Fig. 14). The 52 historical candidate bins cover all 5,177 cells; eight cross-scale stable candidates contain 965 cells. A separate fixed-scale confirmation protocol retained 34 nested units with a union of 2,505 cells. Its twenty finest non-overlapping units cover 2,125 cells, while the other 3,052 remain explicitly represented in the registry. Ten of these twenty units lie entirely within one known fine anatomical type and hemisphere, and two exactly recover the bilateral KCab-p type-by-side classes. The remaining units have mixed fine-type memberships, with dominant type-by-side purity ranging down to 67.3%. Thus, structural stability, anatomical correspondence and subdivision depth provide complementary descriptions of the same population. Known-class recovery supplies interpretable anchors, while partial and mixed units nominate specific within-type and boundary comparisons.
10
+
11
+ """
12
+ assert marker in s;s=s.replace(marker,paragraph+marker,1)
13
+ method="""### Complete classification crosswalk and directed fingerprints
14
+
15
+ We integrated the immutable 5,177-cell structural registry with the 52 historical candidates, eight stable candidates, nine cross-method consensus views, all forty selected scale-conditional sets (34 confirmed and six unconfirmed), and the twenty finest non-overlapping confirmed sets. We retained every original membership rather than projecting nested units onto a forced partition. The multiscale discovery and confirmation used eight fixed scales (K = 3, 9, 20, 30, 40, 50, 75 and 100), each with twenty initialization runs and twenty 20%-directed-pair-dropout runs in each batch. Stability S and coverage both had to reach 0.80 in initialization and dropout separately in discovery and confirmation. Confirmation is a within-connectome algorithmic stability test. Unconfirmed sets remain in the distributed tables.
16
+
17
+ The crosswalk additionally retains all 23 full-population representation fits across K = 20, 40, 80 and 160, initialization and grid sensitivities, three complete within-known-parent refinements, thirty 61-cell local refits, and historical method controls. Labels are qualified by method, scale, seed and parent context. In total, 72 namespaces comprise 4,038 class entries and 230,899 cell-to-class membership records. These include multiple representations and residual groups of the same cells; the entry count is not a count of biological types. Unassigned states are explicit in the cell registry and namespace coverage table.
18
+
19
+ For anatomical correspondence, we used the archived fine source annotation and hemisphere jointly. Each class records the dominant type-by-side count, its fraction of class members (purity), and its fraction of all cells of that known type and side (coverage). The original coarse official field and all source strings are retained. A single raw official alias for an alpha-prime/beta-prime ap1 cell explains why fine-source correspondence includes one cell omitted by the older normalized coarse-field ap1 denominator; the historical entry table is preserved unchanged. Root IDs remain decimal strings throughout CSV, Parquet and text-safe Excel export. The original 32/15/14 cell memberships and the 32-cell simulation order are unchanged.
20
+
21
+ We counted directed endpoints by class, direction and partner cell type. Fractions use all endpoints of the same direction, including KC contacts and unannotated partners. Input ALPN, direct visual projection and APL fractions use all input endpoints; MBON output fractions use all output endpoints. The three highest-count non-KC partner types are also listed, with complete partner counts retained. These full-direction denominators differ from external-only fingerprints in the earlier multiscale archive. Centroids use the original soma coordinates in micrometres. These are descriptive anatomical profiles; nested classes share observations and are not treated as independent samples.
22
+
23
+ """
24
+ s=s.replace('## Methods\n\n','## Methods\n\n'+method,1)
25
+ s=s.replace('Source data and vector artwork for every main figure are available in the `wu_20261108_active_refinement` release', 'The complete classification crosswalk, all class member lists, raw structural atlas, classification replay archive and atlas-integrated article are available in the `wu_20261109_full_atlas_briefing` release. Source data and vector artwork for every main figure are preserved in the `wu_20261108_active_refinement` release')
26
+ s=s.replace('The manuscript release includes the compact inputs required to reproduce the new main figures independently of the large simulation archives.', 'The atlas successor includes code to rebuild all class profiles and vector atlas panels from the released raw data, together with the frozen dynamical source release and an independently compiling Overleaf package.')
27
+ (P/'manuscript/article.md').write_text(s)
28
+ legends=json.loads((A/'manuscript/legends.json').read_text())
29
+ legends['ExtendedData24']='Complete KC classification crosswalk and anatomical fingerprints. a, Unique-cell coverage for known fine anatomical labels, the complete historical partition, cross-scale stable candidates, the union of confirmed nested units, and the finest non-overlapping display set. Counts describe overlapping views of the same 5,177 cells and cannot be added across rows. b, Stable candidate coverage of the dominant known fine type and side, with class purity. Fine-source annotation retains the raw official ap1 alias and therefore differs by one cell from the historical normalized-field entry table for CM020. c, All twenty finest units, their cell counts, dominant known fine type and side, and purity: ten are pure type-by-side subsets and two recover complete known KCab-p classes. d, ALPN, APL and direct visual projection input fractions and MBON output fraction for every finest unit. Denominators are all same-direction endpoint records including KC contacts and unknown partners. Class memberships, unconfirmed units and all remaining cells are retained. This figure summarizes anatomical correspondence and algorithmic stability, not new physiological type assignments.'
30
+ (P/'manuscript/legends.json').write_text(json.dumps(legends,indent=2)+'\n')
31
+ layout=(A/'code/journal_layout.py').read_text().replace('range(1,24)','range(1,25)')
32
+ (P/'code/journal_layout.py').write_text(layout)
33
+ build=(A/'code/build_paper.py').read_text().replace('8 November 2026','9 November 2026').replace('Supplementary Figures 1--13','Supplementary Figures 1--14').replace('supplementary_figures=13','supplementary_figures=14')
34
+ (P/'code/build_paper.py').write_text(build)
35
+ shutil.copy2(A/'metadata/mesh_source_attribution.json',P/'metadata/mesh_source_attribution.json')
36
+ print('Article adds full-population class correspondence, complete method and Supplementary Fig. 14.')
37
+ if __name__=='__main__':main()
wu_20261109_full_atlas_briefing/data/KC5177_master.csv ADDED
The diff for this file is too large to render. See raw diff
 
wu_20261109_full_atlas_briefing/data/KC5177_master.parquet ADDED
@@ -0,0 +1,3 @@
 
 
 
 
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+ size 1257910
wu_20261109_full_atlas_briefing/data/active_cells.csv ADDED
The diff for this file is too large to render. See raw diff
 
wu_20261109_full_atlas_briefing/data/active_pair_summary.csv ADDED
@@ -0,0 +1,13 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ seed,mask,stage,original_count,reassigned_count,count_change,absolute_cell_count_change,common_acquisition_count_change,cell_count_changes,original_responding,reassigned_responding,response_status_changes,paired_onsets,maxabs_first_peak_change_ms,max_soma_RMS_assignment_mV
2
+ 20261109,2,fine,160,157,-3,3,-3,1,32,32,0,32,10.349999999999994,12.713817545768887
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+ 20261109,4,main,188,158,-30,30,-30,30,32,32,0,32,3.2999999999999545,9.743736034957461
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+ 20261110,2,fine,157,158,1,3,1,2,32,32,0,32,31.68750000000003,9.449405324214943
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+ 20261110,2,main,127,158,31,31,31,31,32,32,0,32,32.19999999999999,11.070103838071004
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+ 20261110,4,fine,93,186,93,93,93,32,31,32,1,31,13.225000000000023,13.152969904811838
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+ 20261110,4,main,188,216,28,30,28,30,32,32,0,32,210.75,16.77204642440717
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+ 20261111,2,main,187,128,-59,63,-59,31,32,32,0,32,18.525000000000034,14.1313484765833
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+ 20261111,4,fine,157,187,30,32,30,31,32,32,0,32,51.80000000000001,13.736395419930219
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+ 20261111,4,main,159,188,29,31,29,31,32,32,0,32,56.92499999999998,14.337999680069034
wu_20261109_full_atlas_briefing/data/all_class_memberships.csv ADDED
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wu_20261109_full_atlas_briefing/data/all_class_memberships.parquet ADDED
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wu_20261109_full_atlas_briefing/data/all_class_partner_fingerprints.parquet ADDED
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+ size 6169762
wu_20261109_full_atlas_briefing/data/async_run_summary.csv ADDED
@@ -0,0 +1,18 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ stage,condition,seed,mask,n_waveforms,responding_cells,mean_soma_mV,first_input_ms,input_event_count,active_contacts,distinct_contact_trains,n_internal_arrivals,n_MBON_arrivals
2
+ main,synchronous_engine_gate_m1,0,1,559,32,-51.88924595109778,100.0,1008,56,1,33037,2542
3
+ main,contact_async_s20261109_m1,20261109,1,252,32,-59.81205501744324,100.196166,1008,56,56,15134,1154
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+ main,contact_async_s20261109_m2,20261109,2,158,32,-62.99585493278222,100.196504,2376,132,132,9583,711
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+ main,contact_async_s20261109_m4,20261109,4,188,32,-61.96453539987135,100.152811,3870,215,215,11432,863
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+ main,contact_async_s20261109_m7,20261109,7,281,32,-58.440649686254275,100.152811,7254,403,403,17106,1302
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+ main,contact_async_s20261110_m1,20261110,1,255,32,-59.56677455823665,100.154308,1008,56,56,15486,1159
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+ main,contact_async_s20261111_m7,20261111,7,312,32,-57.43858119146046,100.00526,7254,403,403,18921,1444
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+ fine,contact_async_s20261109_m1,20261109,1,250,32,-59.68553615818085,100.196166,1008,56,56,15128,1149
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+ fine,contact_async_s20261109_m2,20261109,2,160,32,-63.02505910444568,100.196504,2376,132,132,9623,711
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+ fine,contact_async_s20261109_m4,20261109,4,125,32,-63.993774356301046,100.152811,3870,215,215,7683,583
wu_20261109_full_atlas_briefing/data/cell_input_family_profiles.csv ADDED
The diff for this file is too large to render. See raw diff
 
wu_20261109_full_atlas_briefing/data/centroid_runs.csv ADDED
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1
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+ SU034,67,20;30;40;50;75;100,CONFIRMED_SCALE_CONDITIONAL,COMPUTED_MODEL_RESULT,wu_20261026_scale_conditional_v1,KCab-p,left,1.0,67,True,"{""CM031"": 67}",KCab-p,429.6287164179104,127.51420895522388,204.54149253731345,106.49599999999998,72.448,59.120000000000005,32.83829333982888,53.078926289065,69.12647420459386,17077,24933,948,3918,3455,7822,7161,11474,0.0055044797095508,0.0346079522164314,0.1056977220823329,0.1381301889062688,0.1488388882204307,0.1592668351181165,0.1888447248492856,0.2428397742039307
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+ SU037,50,75,CONFIRMED_SCALE_CONDITIONAL,COMPUTED_MODEL_RESULT,wu_20261026_scale_conditional_v1,KCapbp-ap2,left,1.0,0,False,"{""CM025"": 50}",KCapbp-ap2,439.02344,127.8636,199.5288,100.48000000000002,76.06400000000001,72.0,31.345596692358548,59.25616808400625,80.1395778376702,8307,17131,904,3670,1067,1711,4417,8851,0.1593836523413988,0.0,0.1579390875165523,0.2177339326367404,0.1165722958379545,0.1813087385441597,0.2246458351443157,0.3402830272367351
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wu_20261109_full_atlas_briefing/data/member_list_index.csv ADDED
The diff for this file is too large to render. See raw diff
 
wu_20261109_full_atlas_briefing/data/namespace_dictionary.csv ADDED
@@ -0,0 +1,73 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ namespace,n_classes,covered_cells,unassigned_cells,membership_rows,overlap,complete_partition,scope_note_cn
2
+ known_fine_anatomy,12,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
3
+ official_annotation_raw,11,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
4
+ legacy52,52,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
5
+ evidence_state,4,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
6
+ stable8,8,965,4212,965,False,False,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
7
+ consensus9,9,1015,4162,1015,False,False,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
8
+ scale_units40,40,3848,1329,5431,True,False,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
9
+ finest20,20,2125,3052,2125,False,False,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
10
+ original61,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
11
+ global_full_K20_s2026110301,20,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
12
+ global_full_K40_s2026110301,40,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
13
+ global_full_K80_s2026110301,80,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
14
+ global_full_K80_s2026110302,80,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
15
+ global_full_K80_s2026110303,80,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
16
+ global_full_K80_s2026110304,80,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
17
+ global_full_K80_s2026110305,80,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
18
+ global_full_K80_s2026110306,80,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
19
+ global_full_K160_s2026110301,160,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
20
+ global_full_width20_K80_s2026110301,80,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
21
+ global_full_width80_K80_s2026110301,80,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
22
+ global_identity_position_K20_s2026110301,20,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
23
+ global_identity_position_K40_s2026110301,40,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
24
+ global_identity_position_K80_s2026110301,80,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
25
+ global_identity_position_K160_s2026110301,160,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
26
+ global_partner_identity_K20_s2026110301,20,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
27
+ global_partner_identity_K40_s2026110301,40,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
28
+ global_partner_identity_K80_s2026110301,80,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
29
+ global_partner_identity_K160_s2026110301,160,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
30
+ global_soma_tree_K20_s2026110301,20,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
31
+ global_soma_tree_K40_s2026110301,40,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
32
+ global_soma_tree_K80_s2026110301,80,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
33
+ global_soma_tree_K160_s2026110301,160,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
34
+ parent_refinement_full,219,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
35
+ parent_refinement_identity_position,219,5177,0,5177,False,True,见���协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
36
+ parent_refinement_soma_tree,219,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
37
+ focal61_full_s2026110310,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
38
+ focal61_full_s2026110311,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
39
+ focal61_full_s2026110312,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
40
+ focal61_full_s2026110313,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
41
+ focal61_full_s2026110314,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
42
+ focal61_full_s2026110315,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
43
+ focal61_full_s2026110316,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
44
+ focal61_full_s2026110317,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
45
+ focal61_full_s2026110318,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
46
+ focal61_full_s2026110319,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
47
+ focal61_identity_position_s2026110310,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
48
+ focal61_identity_position_s2026110311,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
49
+ focal61_identity_position_s2026110312,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
50
+ focal61_identity_position_s2026110313,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
51
+ focal61_identity_position_s2026110314,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
52
+ focal61_identity_position_s2026110315,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
53
+ focal61_identity_position_s2026110316,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
54
+ focal61_identity_position_s2026110317,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
55
+ focal61_identity_position_s2026110318,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
56
+ focal61_identity_position_s2026110319,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
57
+ focal61_soma_tree_s2026110310,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
58
+ focal61_soma_tree_s2026110311,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
59
+ focal61_soma_tree_s2026110312,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
60
+ focal61_soma_tree_s2026110313,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
61
+ focal61_soma_tree_s2026110314,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
62
+ focal61_soma_tree_s2026110315,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
63
+ focal61_soma_tree_s2026110316,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
64
+ focal61_soma_tree_s2026110317,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
65
+ focal61_soma_tree_s2026110318,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
66
+ focal61_soma_tree_s2026110319,3,61,5116,61,False,False,仅原61细胞;其余细胞在该分析范围之外
67
+ historical_wu_20261026_density_refinement,252,5177,0,9468,True,False,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
68
+ historical_wu_20261027_branch_contact_model,116,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
69
+ historical_wu_20261027_local_tree_refinement,360,5177,0,15531,True,False,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
70
+ historical_wu_20261028_open_tools,30,5177,0,5177,False,True,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
71
+ historical_wu_20261028_parent_free_model,172,5177,0,20708,True,False,见原协议;covered_cells包括明确的残余角色,未覆盖不表示没有生物功能
72
+ historical_spatial_explanation_registry,422,61,5116,7796,True,False,仅原61细胞;其余细胞在该分析范围之外
73
+ historical_spatial_explanation_resolution_solver_audit,20,61,5116,305,True,False,仅原61细胞;其余细胞在该分析范围之外
wu_20261109_full_atlas_briefing/data/numerical_grid_summary.csv ADDED
@@ -0,0 +1,6 @@
 
 
 
 
 
 
 
1
+ condition,total_count,responding_cells,count_cells_changed_vs_original,count_cells_changed_vs_sample_control,maxabs_onset_vs_original_ms,maxabs_onset_vs_sample_ms,max_soma_RMS_vs_sample_mV,KCmesh_um,MBONmesh_um,dt_ms,initiation_sample_ms
2
+ async_R1_m4,188,32,0,0,0.0,0.0875000000000341,0.0,0.25,0.5,0.0025,0.025
3
+ async_R1_L_sample_control,188,32,0,0,0.0875000000000341,0.0,0.0,0.25,0.5,0.0025,0.0125
4
+ async_R1_L_time_only,192,32,3,3,3.6374999999999886,3.6374999999999886,12.730232467094527,0.25,0.5,0.00125,0.0125
5
+ async_R1_L_space_only,158,32,30,30,2.474999999999966,2.474999999999966,13.31578715421701,0.125,0.25,0.0025,0.0125
6
+ async_R1_L_joint,125,32,32,32,5.149999999999977,5.149999999999977,13.207272204971794,0.125,0.25,0.00125,0.0125
wu_20261109_full_atlas_briefing/data/previous_public_data_objects.json ADDED
The diff for this file is too large to render. See raw diff
 
wu_20261109_full_atlas_briefing/data/profile_cells.csv ADDED
@@ -0,0 +1,65 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ weight_nS,gid,root_id,eligible,amplitude_mV,fine_amplitude_mV,observed_refinement_rms_mV,orientation_refinement_rms,orientation_resolved
2
+ 0.1,0,720575940606579465,False,0.0,0.0,0.0,,False
3
+ 0.1,1,720575940606698697,False,0.0,0.0,0.0,,False
4
+ 0.1,2,720575940615832577,True,0.05519420266499547,0.05520126857541504,3.746872405832935e-05,0.0006666295695448744,True
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+ 0.1,3,720575940618341952,True,0.029707565305681492,0.02973465136844693,6.469999362036444e-05,0.001976959446005633,True
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+ 0.1,4,720575940618662939,False,0.0,0.0,0.0,,False
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+ 0.1,5,720575940619077217,False,0.0,0.0,0.0,,False
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+ 0.1,6,720575940619897734,False,0.0,0.0,0.0,,False
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+ 0.1,7,720575940620333958,False,0.0,0.0,0.0,,False
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+ 0.1,8,720575940621606755,False,0.0,0.0,0.0,,False
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+ 0.1,9,720575940621770010,True,0.014868670072770734,0.014863661504821163,1.3058765756759203e-05,0.0008112437116015559,True
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+ 0.1,10,720575940622003316,False,0.0,0.0,0.0,,False
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+ 0.1,11,720575940622412838,False,0.0,0.0,0.0,,False
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+ 0.1,12,720575940622836455,True,0.006864764352826571,0.006855454764740353,2.355516853051703e-05,0.0031540918288755883,True
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+ 0.1,13,720575940623973961,False,0.0,0.0,0.0,,False
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+ 0.1,14,720575940624107755,False,0.0,0.0,0.0,,False
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+ 0.1,15,720575940625328915,False,0.0,0.0,0.0,,False
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+ 0.1,16,720575940625500304,False,0.0,0.0,0.0,,False
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+ 0.1,17,720575940626305028,True,0.009855169199871075,0.009834756578099344,4.605182361408828e-05,0.004193079467061918,True
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+ 0.1,18,720575940627585028,False,0.0,0.0,0.0,,False
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+ 0.1,19,720575940627626244,False,0.0,0.0,0.0,,False
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+ 0.1,20,720575940629319106,True,0.017127577839971285,0.01711212209070044,3.5440801479330636e-05,0.001862931598570388,True
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+ 0.1,21,720575940629507706,True,0.01689198813838252,0.016904243719487587,4.754411328003443e-05,0.0027184917708093924,True
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+ 0.1,22,720575940630331244,True,0.015776790577302226,0.01578144977496878,2.4837775548420877e-05,0.001546148578499754,True
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+ 0.1,23,720575940630775891,False,0.0,0.0,0.0,,False
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+ 0.1,24,720575940630923693,False,0.0,0.0,0.0,,False
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+ 0.1,25,720575940632437331,True,0.0029111109740949507,0.0029083956493533387,7.721167592222387e-06,0.0024840467276466016,True
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+ 0.1,26,720575940633103059,False,0.0,0.0,0.0,,False
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+ 0.1,27,720575940634514533,False,0.0,0.0,0.0,,False
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+ 0.1,28,720575940634664674,False,0.0,0.0,0.0,,False
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+ 0.1,29,720575940643769544,False,0.0,0.0,0.0,,False
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+ 0.1,30,720575940644413732,False,0.0,0.0,0.0,,False
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+ 0.1,31,720575940649022841,True,0.39244155820806687,0.3923408536369318,0.00016909449628021894,0.00034617605483753497,True
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+ 1.0,0,720575940606579465,False,9.455700418835812,9.456692318816552,0.2112224834704528,0.022336692950366843,True
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+ 1.0,1,720575940606698697,False,12.52242877366163,12.524712614747973,0.4173731710666863,0.03332651161756826,True
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+ 1.0,2,720575940615832577,True,8.797536316055393,8.791164850933061,0.099979227076105,0.011345466173425517,True
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+ 1.0,3,720575940618341952,True,9.258017460092212,9.252125441778011,0.10298138398544018,0.011108795585248075,True
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+ 1.0,4,720575940618662939,False,10.123013226416738,10.12306889098427,0.21663105474929004,0.02139979936288592,True
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+ 1.0,5,720575940619077217,False,10.06395310112888,10.056182870595384,0.1862179872405347,0.01849448913969597,True
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+ 1.0,6,720575940619897734,False,10.015603441870631,10.014690799999526,0.25325266269705177,0.025286799630732177,True
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+ 1.0,7,720575940620333958,False,11.52440885979233,11.52574087106008,0.23252633618738044,0.020175358866777092,True
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+ 1.0,8,720575940621606755,False,9.665302284727106,9.66681616666674,0.2874792590810535,0.029740690298784872,True
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+ 1.0,9,720575940621770010,True,11.276877111252,11.273537567549653,0.41266611049054897,0.03659822738237355,True
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+ 1.0,10,720575940622003316,False,10.104407264969268,10.112102000893682,0.25373892807577225,0.02509060721422505,True
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+ 1.0,11,720575940622412838,False,12.640639744561721,12.63916658444991,0.4128955196445501,0.03266582717739691,True
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+ 1.0,12,720575940622836455,True,9.560631976406425,9.55975074006448,0.2097040158637712,0.02193493379124783,True
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+ 1.0,13,720575940623973961,False,9.990078246968952,9.987520658323298,0.22683009833283566,0.022707001172217366,True
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+ 1.0,14,720575940624107755,False,11.502321440032176,11.499678331049033,0.23425462638421554,0.020366900148571312,True
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+ 1.0,15,720575940625328915,False,11.113802603282398,11.11421921629869,0.2638869111523419,0.023743595761715353,True
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+ 1.0,16,720575940625500304,False,10.202480017048567,10.19761825162353,0.198754737695885,0.019479834821072465,True
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+ 1.0,17,720575940626305028,True,10.561249805061168,10.564147492359966,0.20019763047525607,0.01895128008100888,True
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+ 1.0,18,720575940627585028,False,10.283916550157183,10.285718276529032,0.29371131851960136,0.028557219986060162,True
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+ 1.0,19,720575940627626244,False,9.702754298012382,9.701083795298585,0.20201854168141306,0.020821822425021758,True
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+ 1.0,20,720575940629319106,True,9.207047640504712,9.202213898829935,0.22624178158058866,0.024573516502659373,True
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+ 1.0,21,720575940629507706,True,10.00509690486616,9.999635181664813,0.1053653889172509,0.010519885010080136,True
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+ 1.0,22,720575940630331244,True,8.757236279048495,8.757149511249834,0.23889143261453727,0.027279451271688276,True
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+ 1.0,23,720575940630775891,False,10.464598610949741,10.467288258471577,0.28755161649792293,0.027473781166952604,True
58
+ 1.0,24,720575940630923693,False,9.41932935089379,9.420992082749892,0.22148823624332087,0.023511488024251247,True
59
+ 1.0,25,720575940632437331,True,9.822315844446946,9.82086793684729,0.2666155275606638,0.027145456627820082,True
60
+ 1.0,26,720575940633103059,False,11.780726745487145,11.780306649710175,0.4018849286865486,0.03411435334295469,True
61
+ 1.0,27,720575940634514533,False,10.393850472524734,10.400685656156929,0.22502385652920542,0.021632608941537793,True
62
+ 1.0,28,720575940634664674,False,11.50366064983821,11.50157360363157,0.45789026684742323,0.03980707236656624,True
63
+ 1.0,29,720575940643769544,False,12.866647036702991,12.861177375454735,0.18343145137355696,0.014253042600166655,True
64
+ 1.0,30,720575940644413732,False,9.7072440777819,9.708127369552347,0.22032112478037982,0.022695353008483427,True
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+ 1.0,31,720575940649022841,True,8.013528675231395,8.007661212521947,0.11148490059539114,0.013897893872408801,True
wu_20261109_full_atlas_briefing/data/schedule_masks.csv ADDED
@@ -0,0 +1,21 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ schedule,mask,total_waveforms,responding_cells,mean_soma_mV
2
+ synchronous,1,559,32,-51.889245951097735
3
+ synchronous,2,0,0,-69.4666423914508
4
+ synchronous,4,0,0,-69.41814503150141
5
+ synchronous,7,559,32,-51.8641808874644
6
+ jittered_seed20261106,1,524,32,-52.760763274815346
7
+ jittered_seed20261106,2,0,0,-69.46847808652672
8
+ jittered_seed20261106,4,0,0,-69.42002517583455
9
+ jittered_seed20261106,7,551,32,-51.9487440983519
10
+ jittered_seed20261107,1,406,32,-56.14146997407278
11
+ jittered_seed20261107,2,0,0,-69.47332323800387
12
+ jittered_seed20261107,4,0,0,-69.424783566559
13
+ jittered_seed20261107,7,435,32,-55.183354635123095
14
+ jittered_seed20261108,1,494,32,-53.45230047240095
15
+ jittered_seed20261108,2,0,0,-69.4695569787789
16
+ jittered_seed20261108,4,0,0,-69.42110327934355
17
+ jittered_seed20261108,7,465,32,-54.42511696460077
18
+ bursty_three_epochs,1,96,32,-67.22704586167686
19
+ bursty_three_epochs,2,96,32,-67.27364448303024
20
+ bursty_three_epochs,4,96,32,-67.2604111604264
21
+ bursty_three_epochs,7,96,32,-67.20574192974635
wu_20261109_full_atlas_briefing/data/source_original61_with_simulation_order.csv ADDED
@@ -0,0 +1,62 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ root_id,candidate,cluster_size,cohort_order,group_order,official_KC_subtype,hemisphere,soma_x_um,soma_y_um,soma_z_um,dataset_version,coordinate_space,simulation_gid,in_current_32_KC_simulation
2
+ 720575940606579465,abp_R_K3_C0,32,1,1,KCab-p,right,610.624,104.0,171.96,FlyWire v783,FAFB14 um,0,True
3
+ 720575940606698697,abp_R_K3_C0,32,2,2,KCab-p,right,592.256,105.152,168.08,FlyWire v783,FAFB14 um,1,True
4
+ 720575940615832577,abp_R_K3_C0,32,3,3,KCab-p,right,617.44,106.08,169.04,FlyWire v783,FAFB14 um,2,True
5
+ 720575940618341952,abp_R_K3_C0,32,4,4,KCab-p,right,603.392,104.48,169.32,FlyWire v783,FAFB14 um,3,True
6
+ 720575940618662939,abp_R_K3_C0,32,5,5,KCab-p,right,577.28,112.352,164.72,FlyWire v783,FAFB14 um,4,True
7
+ 720575940619077217,abp_R_K3_C0,32,6,6,KCab-p,right,624.704,118.872,191.68,FlyWire v783,FAFB14 um,5,True
8
+ 720575940619897734,abp_R_K3_C0,32,7,7,KCab-p,right,622.656,104.992,175.84,FlyWire v783,FAFB14 um,6,True
9
+ 720575940620333958,abp_R_K3_C0,32,8,8,KCab-p,right,605.28,117.76,165.08,FlyWire v783,FAFB14 um,7,True
10
+ 720575940621606755,abp_R_K3_C0,32,9,9,KCab-p,right,619.072,104.352,167.04,FlyWire v783,FAFB14 um,8,True
11
+ 720575940621770010,abp_R_K3_C0,32,10,10,KCab-p,right,611.424,102.496,168.76,FlyWire v783,FAFB14 um,9,True
12
+ 720575940622003316,abp_R_K3_C0,32,11,11,KCab-p,right,616.736,108.768,177.0,FlyWire v783,FAFB14 um,10,True
13
+ 720575940622412838,abp_R_K3_C0,32,12,12,KCab-p,right,604.0,111.072,169.92,FlyWire v783,FAFB14 um,11,True
14
+ 720575940622836455,abp_R_K3_C0,32,13,13,KCab-p,right,619.744,105.6,172.64,FlyWire v783,FAFB14 um,12,True
15
+ 720575940623973961,abp_R_K3_C0,32,14,14,KCab-p,right,616.288,106.72,174.2,FlyWire v783,FAFB14 um,13,True
16
+ 720575940624107755,abp_R_K3_C0,32,15,15,KCab-p,right,597.536,103.392,166.16,FlyWire v783,FAFB14 um,14,True
17
+ 720575940625328915,abp_R_K3_C0,32,16,16,KCab-p,right,608.064,121.024,187.8,FlyWire v783,FAFB14 um,15,True
18
+ 720575940625500304,abp_R_K3_C0,32,17,17,KCab-p,right,620.104,111.376,175.72,FlyWire v783,FAFB14 um,16,True
19
+ 720575940626305028,abp_R_K3_C0,32,18,18,KCab-p,right,590.016,103.296,163.96,FlyWire v783,FAFB14 um,17,True
20
+ 720575940627585028,abp_R_K3_C0,32,19,19,KCab-p,right,626.4,106.848,167.84,FlyWire v783,FAFB14 um,18,True
21
+ 720575940627626244,abp_R_K3_C0,32,20,20,KCab-p,right,618.944,105.216,176.96,FlyWire v783,FAFB14 um,19,True
22
+ 720575940629319106,abp_R_K3_C0,32,21,21,KCab-p,right,604.224,101.152,167.0,FlyWire v783,FAFB14 um,20,True
23
+ 720575940629507706,abp_R_K3_C0,32,22,22,KCab-p,right,600.256,100.672,162.04,FlyWire v783,FAFB14 um,21,True
24
+ 720575940630331244,abp_R_K3_C0,32,23,23,KCab-p,right,598.304,108.192,168.16,FlyWire v783,FAFB14 um,22,True
25
+ 720575940630775891,abp_R_K3_C0,32,24,24,KCab-p,right,596.64,100.032,160.2,FlyWire v783,FAFB14 um,23,True
26
+ 720575940630923693,abp_R_K3_C0,32,25,25,KCab-p,right,609.856,116.96,188.24,FlyWire v783,FAFB14 um,24,True
27
+ 720575940632437331,abp_R_K3_C0,32,26,26,KCab-p,right,599.488,108.736,157.52,FlyWire v783,FAFB14 um,25,True
28
+ 720575940633103059,abp_R_K3_C0,32,27,27,KCab-p,right,601.28,124.96,167.16,FlyWire v783,FAFB14 um,26,True
29
+ 720575940634514533,abp_R_K3_C0,32,28,28,KCab-p,right,617.632,101.216,169.68,FlyWire v783,FAFB14 um,27,True
30
+ 720575940634664674,abp_R_K3_C0,32,29,29,KCab-p,right,611.008,107.488,179.16,FlyWire v783,FAFB14 um,28,True
31
+ 720575940643769544,abp_R_K3_C0,32,30,30,KCab-p,right,600.864,105.952,166.76,FlyWire v783,FAFB14 um,29,True
32
+ 720575940644413732,abp_R_K3_C0,32,31,31,KCab-p,right,590.72,106.784,169.64,FlyWire v783,FAFB14 um,30,True
33
+ 720575940649022841,abp_R_K3_C0,32,32,32,KCab-p,right,606.336,110.816,173.72,FlyWire v783,FAFB14 um,31,True
34
+ 720575940607054770,abp_R_K3_C1,15,33,1,KCab-p,right,638.496,175.84,213.24,FlyWire v783,FAFB14 um,,False
35
+ 720575940609371086,abp_R_K3_C1,15,34,2,KCab-p,right,653.152,172.64,207.0,FlyWire v783,FAFB14 um,,False
36
+ 720575940610823010,abp_R_K3_C1,15,35,3,KCab-p,right,632.992,179.008,214.4,FlyWire v783,FAFB14 um,,False
37
+ 720575940612767126,abp_R_K3_C1,15,36,4,KCab-p,right,617.92,168.192,212.2,FlyWire v783,FAFB14 um,,False
38
+ 720575940615671494,abp_R_K3_C1,15,37,5,KCab-p,right,632.896,182.048,214.2,FlyWire v783,FAFB14 um,,False
39
+ 720575940617478427,abp_R_K3_C1,15,38,6,KCab-p,right,621.76,173.76,209.08,FlyWire v783,FAFB14 um,,False
40
+ 720575940617771521,abp_R_K3_C1,15,39,7,KCab-p,right,626.688,169.696,213.36,FlyWire v783,FAFB14 um,,False
41
+ 720575940621925417,abp_R_K3_C1,15,40,8,KCab-p,right,624.032,156.544,208.96,FlyWire v783,FAFB14 um,,False
42
+ 720575940627085578,abp_R_K3_C1,15,41,9,KCab-p,right,636.608,179.296,213.32,FlyWire v783,FAFB14 um,,False
43
+ 720575940628045318,abp_R_K3_C1,15,42,10,KCab-p,right,619.008,165.504,209.92,FlyWire v783,FAFB14 um,,False
44
+ 720575940628826873,abp_R_K3_C1,15,43,11,KCab-p,right,641.856,177.696,212.12,FlyWire v783,FAFB14 um,,False
45
+ 720575940631485251,abp_R_K3_C1,15,44,12,KCab-p,right,641.696,174.016,212.12,FlyWire v783,FAFB14 um,,False
46
+ 720575940632366623,abp_R_K3_C1,15,45,13,KCab-p,right,636.352,175.072,210.2,FlyWire v783,FAFB14 um,,False
47
+ 720575940633226603,abp_R_K3_C1,15,46,14,KCab-p,right,623.968,162.496,209.96,FlyWire v783,FAFB14 um,,False
48
+ 720575940634351200,abp_R_K3_C1,15,47,15,KCab-p,right,626.848,173.184,214.4,FlyWire v783,FAFB14 um,,False
49
+ 720575940608191836,abp_R_K3_C2,14,48,1,KCab-p,right,681.664,112.256,164.56,FlyWire v783,FAFB14 um,,False
50
+ 720575940610580377,abp_R_K3_C2,14,49,2,KCab-p,right,686.304,126.016,179.12,FlyWire v783,FAFB14 um,,False
51
+ 720575940615196063,abp_R_K3_C2,14,50,3,KCab-p,right,675.692,124.728,183.04,FlyWire v783,FAFB14 um,,False
52
+ 720575940616860318,abp_R_K3_C2,14,51,4,KCab-p,right,670.632,120.672,182.36,FlyWire v783,FAFB14 um,,False
53
+ 720575940617750173,abp_R_K3_C2,14,52,5,KCab-p,right,678.752,118.976,172.16,FlyWire v783,FAFB14 um,,False
54
+ 720575940619684688,abp_R_K3_C2,14,53,6,KCab-p,right,677.004,127.976,185.08,FlyWire v783,FAFB14 um,,False
55
+ 720575940619937718,abp_R_K3_C2,14,54,7,KCab-p,right,672.96,130.88,185.32,FlyWire v783,FAFB14 um,,False
56
+ 720575940620700769,abp_R_K3_C2,14,55,8,KCab-p,right,696.112,122.052,166.44,FlyWire v783,FAFB14 um,,False
57
+ 720575940621762330,abp_R_K3_C2,14,56,9,KCab-p,right,689.152,126.592,169.88,FlyWire v783,FAFB14 um,,False
58
+ 720575940625126448,abp_R_K3_C2,14,57,10,KCab-p,right,679.524,123.96,182.44,FlyWire v783,FAFB14 um,,False
59
+ 720575940626043454,abp_R_K3_C2,14,58,11,KCab-p,right,698.432,130.912,176.24,FlyWire v783,FAFB14 um,,False
60
+ 720575940628514156,abp_R_K3_C2,14,59,12,KCab-p,right,628.672,103.68,169.44,FlyWire v783,FAFB14 um,,False
61
+ 720575940630949187,abp_R_K3_C2,14,60,13,KCab-p,right,659.296,115.52,182.64,FlyWire v783,FAFB14 um,,False
62
+ 720575940634969701,abp_R_K3_C2,14,61,14,KCab-p,right,664.8,114.24,177.16,FlyWire v783,FAFB14 um,,False