Datasets:
Align modality labels with paper table; uppercase HERITAGE; group by modality
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README.md
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---
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license: cc-by-4.0
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tags:
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- biology
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- genomics
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- proteomics
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- graph-neural-networks
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- benchmarking
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- omics
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pretty_name: OmicsGBench — Omics Graph Benchmark
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task_categories:
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- tabular-classification
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size_categories:
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- n<1K
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---
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# OmicsGBench: Benchmarking Graph Neural Networks on Omics Data
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## Datasets
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This repository contains six preprocessed omics graph classification datasets:
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| Dataset | Modality | n | p | Task |
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| Parkinson's | Transcriptomics | 535 | 21,755 | Cognitive status (binary) |
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| AddNeuroMed | Transcriptomics | 711 | 17,197 | Clinical diagnosis (3-class) |
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| BRCA | Epigenomics | 640 | 19,049 | Cancer subtype (4-class) |
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| Tuberculosis | Protein microarray | 561 | 3,814 | Culture negative vs positive |
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| Smoking | DNA methylation | 464 | 139,125 | Never- vs ever-smoker |
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Smoking stores 139,125 TSS1500/TSS200 probes
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## Source Data
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- **Parkinson's**: Shamir et al. (2017), *Neurology*. Available via NCBI GEO (GSE99039) under GEO public data access policy.
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- **AddNeuroMed**: Lovestone et al. (2009). Available via NCBI GEO (GSE63063) under GEO public data access policy.
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- **BRCA**: Yang et al. (2025), MLOmics, *Scientific Data*. Available on Figshare/Hugging Face under CC-BY 4.0.
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- **Tuberculosis**: Kunnath-Velayudhan et al. (2010), *PNAS*. Available via NCBI GEO (GSE19433) under GEO public data access policy.
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- **Smoking**: Tsaprouni et al. (2014), *Epigenetics*. Available via NCBI GEO (GSE50660) under GEO public data access policy.
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## Preprocessing
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Datasets share one ingest pipeline: probe-to-gene aggregation where the source is probe-level, and the normalization described in Appendix B of the accompanying paper. Matrices on the Hub are uncorrected. HERITAGE covariate adjustment, AddNeuroMed ComBat, and smoking promoter-probe selection plus median-centering are fit on the training split only.
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The default evaluation is stratified 5-fold. A 70/15/15 train/val/test split is available as `split_type=fixed`. Parkinson's and
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---
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license: cc-by-4.0
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tags:
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| 4 |
+
- biology
|
| 5 |
+
- genomics
|
| 6 |
+
- proteomics
|
| 7 |
+
- graph-neural-networks
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| 8 |
+
- benchmarking
|
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+
- omics
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pretty_name: OmicsGBench — Omics Graph Benchmark
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task_categories:
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+
- tabular-classification
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size_categories:
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+
- n<1K
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---
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# OmicsGBench: Benchmarking Graph Neural Networks on Omics Data
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## Datasets
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This repository contains six preprocessed omics graph classification datasets, grouped by modality:
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| Dataset | Modality | n | p | Task |
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| --- | --- | --- | --- | --- |
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| HERITAGE | Proteomics | 654 | 4,976 | Exercise responder (binary) |
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| Tuberculosis | Proteomics | 561 | 3,814 | Culture negative vs positive |
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| Parkinson's | Transcriptomics | 535 | 21,755 | Cognitive status (binary) |
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| AddNeuroMed | Transcriptomics | 711 | 17,197 | Clinical diagnosis (3-class) |
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| Smoking | Epigenomics | 464 | 139,125 | Never- vs ever-smoker |
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| BRCA | Epigenomics | 640 | 19,049 | Cancer subtype (4-class) |
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Tuberculosis is a full-proteome antibody microarray (immunoproteomics), where each feature is one *M. tuberculosis* protein. Smoking stores 139,125 TSS1500/TSS200 methylation probes; training keeps one probe per gene, about 20,763 genes.
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## Source Data
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- **HERITAGE**: Robbins et al. (2021), *Nature Metabolism*. Available via MoTrPAC Data Hub (motrpac-data.org) under CC-BY 4.0.
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- **Tuberculosis**: Kunnath-Velayudhan et al. (2010), *PNAS*. Available via NCBI GEO (GSE19433) under GEO public data access policy.
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- **Parkinson's**: Shamir et al. (2017), *Neurology*. Available via NCBI GEO (GSE99039) under GEO public data access policy.
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- **AddNeuroMed**: Lovestone et al. (2009). Available via NCBI GEO (GSE63063) under GEO public data access policy.
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- **Smoking**: Tsaprouni et al. (2014), *Epigenetics*. Available via NCBI GEO (GSE50660) under GEO public data access policy.
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- **BRCA**: Yang et al. (2025), MLOmics, *Scientific Data*. Available on Figshare/Hugging Face under CC-BY 4.0.
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## Preprocessing
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| 46 |
|
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Datasets share one ingest pipeline: probe-to-gene aggregation where the source is probe-level, and the normalization described in Appendix B of the accompanying paper. Matrices on the Hub are uncorrected. HERITAGE covariate adjustment, AddNeuroMed ComBat, and smoking promoter-probe selection plus median-centering are fit on the training split only.
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The default evaluation is stratified 5-fold. A 70/15/15 train/val/test split is available as `split_type=fixed`. Parkinson's and Tuberculosis keep each batch inside one fold: hybridization date for Parkinson's, country of serum collection for Tuberculosis.
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