accession stringlengths 6 10 | name stringlengths 6 11 | Full Name stringlengths 1 147 ⌀ | taxon stringlengths 3 46 ⌀ | sequence stringlengths 16 2.75k | function stringlengths 6 5.51k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q9ULZ9 | MMP17_HUMAN | Membrane-type-4 matrix metalloproteinase | Homo | MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRS... | Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln... | Q9ULZ9 |
Q661D9 | RL2_BORGP | 50S ribosomal protein L2 | Borreliella | MGIKTYKPKTSSLRYKTTLSFDDLSKGNDPLKSLTKGKKLKSGRDSSGRISIRRRGGGHKRKYRLIDFNRRDKFSIPARVASIEYDPNRSANIALLVYKDGEKRYIISPKGIKVGDVLESGPNAPIKIGNALPLENIPIGRTIHNIELNVGKGGQLVRSAGGYAMILASDGNYVTVKLSSGEMRLIFKKCIATIGEIGNEDYANVSIGKAGKSRWLGRRPKVRGVAMNPVDHPHGGGEGKTSGGRHPVSPWGQPTKGYKTRKKKRYSDKFIIKRRNK | One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. | Q661D9 |
B7GGF3 | PLSX_ANOFW | Phosphate-acyl-ACP acyltransferase | Anoxybacillus | MKIAIDAMGGDHAPKEIVIGAQKAIEHFQDIEITLVGNETLIRPYITNDERLSIIHTEQVIEATDEPVRAVRRKKEASMVLMANEVSEGRAHACISAGNTGALMAAGLFIVGRIDGIDRPALAPTLPTIDGKGFVLLDVGANVDARPEHILQYALMGAAYAEKVRGIHRPRIGLLNVGTEDQKGNELAKKTFQLIQDTSLNFVGNVEARDLLEGVADVVVTDGFTGNVALKTIEGTAIAVFSMLKSALTSNVVSKMAALALKPQLMQLKKKMDYAEYGGAALFGLRAPVIKAHGSSDAHAIFHAVRQAREMVVNDVIQTV... | Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. | B7GGF3 |
Q8LDB8 | RING2_ARATH | RING-type E3 ubiquitin transferase At1g63170 | Arabidopsis | MSRETTTEATPLILTDGGGGRRSVRRQGLREAARLLRHASSGRMMMREPSMLVREAAAEQLEERQSDWAYSKPVVVLDFVWNLAFVVVATAVLVLSSDENPNMPLRVWIIGYGLQCMMHMVCVCVEYRRRNSRRRRDLSPRSSSSSSSSSSSMDEEEGLGLSRNSDERYLELGQLENENNSFAKHLESANTMISFIWWVIGFYWVSSGGQELAQGSPQLYWLCIVFLGFDVFFVVFCVALACVIGIAVCCCLPCIIAVLYAVAEQEGASKEDIDQLTKFKFRKVGDTMKHTVDEEQGQGDSGGVMTECGTDSPVEHALPH... | Mediates E2-dependent protein ubiquitination. | Q8LDB8 |
Q4FVB4 | RL25_PSYA2 | General stress protein CTC | Psychrobacter | MTINHFALNAVDRSAEVQGKGASRRLRKQNLVPAIIYGGGEQPIAISIKINELVKSLEFEAFFSHILTLNVDGEEHQVVIKDLQRHPAKGFPMHADFQRVVKGQKINMNVPVHFSGREEAPGTKAGGILSTLVTDIEIVCIPSQLPEYLEIDVSGMEIGDLFRLSDIKLPEGVIIFDLDMEDAHDRTIVNMQPPTVQEVDKVAEIDASDVPATEQGTDGNKDGK | This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. | Q4FVB4 |
A9M838 | ATPG_BRUC2 | F-ATPase gamma subunit | Brucella | MPSLKDLRNRIASVKATQKITKAMQMVAAAKLRRAQEAAEAARPYSQRMGAVLANIAQNVSGEDAPALMVGTGKDNVHLLVVCTAERGLCGGFNSQIARLARDHARKLLAEGKTVKIITVGKKGADILRREFSALLHDHVDLREVKQLAFVHADQIGHKIIKLFEEGAFDVCTLFYSEFKSVISQVPTAQQLIPASADNEAEMETAGDAIYEYEPDPAAILSTLIPRNISVQIFRALLENVAGEMGAKMSAMDNATRNAGDMINKLSITYNRQRQAQITKELIEIISGAEAL | Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. | A9M838 |
Q81PL1 | RPIA_BACAN | Phosphoriboisomerase A | Bacillus cereus group | MDLKQIAGEYAATFVKDGMKIGLGTGSTAYWTIQKLGQRVKEGLSIQAVPTSKETEALAQQLNIPLISLNDVQSLDLTIDGADEIDSNLQLIKGGGGALLREKIVASSSKELIIIVDESKVVTRLGTFPLPIEIIPFAWKQTESKIQSLGCQTTLRLKNNETFITDNNNMIIDCIFPNHIPTPSDLHKRLKMITGVVETGLFVNMTSKAIIGTKNGIQEL | Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. | Q81PL1 |
Q9ERG4 | GLHA_MASCO | Thyrotropin alpha chain | Mastomys | MDYCRKYAAVILVMLSVFLHILHSLPDGDFIIQGCPECKLKENKYFSKLGAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKAFTKATVMGNARVENHTECHCSTCYYHKS | Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | Q9ERG4 |
B9JJB7 | 1A1D_AGRRK | 1-aminocyclopropane-1-carboxylate deaminase | Agrobacterium tumefaciens complex | MLEKFERYPLTFGPTHIEKLERLSEHLGGKVQLYAKREDCNSGLAFGGNKLRKLEYIIPDAIASNADTLVSIGGVQSNHTRMIAAVAAKIGFKCRLVQESWVPHEDAVYDRVGNILLSRIMGADVQMVDEGFDIGIRQSWEEAIEDVKAKGGKPYPIPAGASVHKYGGLGYVGFAEEVRVQEEELGFKFDYIVVCTVTGSTHAGMTVGFAKDGRERQVIGIDASFTPAQTKAQVLEIARRTAELVELGRELSSDDIVLIEDYAYPVYGVPSDETKEAIRLCARLEGMITDPVYEGKSMQGMIDLVKKGYFPEGSKVLYAH... | Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate. Allows growth on ACC as a nitrogen source. | B9JJB7 |
Q7VJ25 | ATPF_HELHP | F-type ATPase subunit b | Helicobacter | MKKIAFFVICVGFPSLIFASASIQESDFIQRVINFVIFVAILWYFAFDSIKGIFVNRRNAISARLQEVQENLHKAKREKETAQKRLEESKEKAKNIVNAAKQEAYLLEQKYNDQIKKDIETLKYALESNIEFERRKITHEAVDELLNKLIQSDDVQLNKEDYVNIITKRIS | Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). | Q7VJ25 |
A6VPA5 | FABA_ACTSZ | Trans-2-decenoyl-[acyl-carrier-protein] isomerase | Actinobacillus | MTNTCTPNHKSSYTYEDLLASGRGELFGPKGPQLPAPTMLMMDRVIEMNETGGQYGKGYVEAELDIKPDLFFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWIGGEGKGRALGVGEVKFTGQVLPTAKKVTYRIHLKRVINRKLIMGVADGEVEVDGRVIYTATDLKVGLFQDTSTF | Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active ... | A6VPA5 |
Q12702 | 2ABA_SCHPO | Protein phosphatase 2A 55 kDa regulatory subunit | Schizosaccharomyces | MDDIEDSLDQWKFAQCFGDKGDVEDITEADIISAVEFDHTGDYLATGDKGGRVVLFERNHSKKGCEYKFFTEFQSHEPEFDYLKSLEIEEKINKIRWCKRTNRAHFLLSTNDKTIKLWKLYEKNLKVVAENNLSDSFHSPMQGPLTTPSQLRLPRLNHHDMIIAAYPRRVYANAHAYHINSISVNSDAETYISADDLRINLWNLSISDHSFNIVDIKPENMEELTEVITSAEFHPINCNHLMYSSSKGNIKLLDLRQSALCDNPCKLFEDQEDQDSKSFFSEIISSISDVKFSQNGRYILSRDYLTLKIWDVNMEKAPVK... | Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subs... | Q12702 |
P01497 | SIX1_ANDAU | AaH IT1 | Androctonus | MKFLLLFLVVLPIMGVFGKKNGYAVDSSGKAPECLLSNYCNNECTKVHYADKGYCCLLSCYCFGLNDDKKVLEISDTRKSYCDTTIIN | Excitatory insect beta-toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on insec... | P01497 |
A7ZC38 | ATPE_CAMC1 | F-ATPase epsilon subunit | Campylobacter | MDKLHLEIVTPQGQIFNDDVSSVVLPGSEGEFGVLPNHASLISLLKAGIIDIEDKHKKHDVVAINWGYAKIDEGKVVILADGAVYVSGNSESELANSLEAARNLIESMSSDTNAFAATISKMENVVRAR | Produces ATP from ADP in the presence of a proton gradient across the membrane. | A7ZC38 |
Q62MN2 | FDHD_BURMA | Sulfur carrier protein FdhD | pseudomallei group | MSLSETVEPSGIVELAVRRRRGDAAETAVDRVGQEWPVALVFNGISHAVMMCTPRDLEAFAVGFAVSEGIVERGSDVKDIEVALHGAGPLPHAEVQLTVVQQAFAALKEKRRALAGRTGCGVCGIESIGLLDLVPQRLPDTGFLARLAPDAIARAARELPAHQALTRQTGGLHAAAWCDASGAIVHAFEDIGRHNALDKLIGTLTLTRADMANGFVFLSSRASYELVRKSARVGIPMVATISAPSSLAIEIARQAGLRLVSFCREAGYVDYGTA | Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. | Q62MN2 |
C1DBG0 | TRMD_LARHH | tRNA [GM37] methyltransferase | Laribacter | MRIDAVTLFAPMFEALTRSGVTRRAAEQGIWSFHAWNPRDFTTDNYHTVDDRPYGGGPGMVMLCEPLQQALRQAVAAQQADGAARIRRIYLSPQGEQLTDRKVQELAGLDGLVLLCGRYEGVDERLLQSEIDEEISIGDYVLSGGELPAMVLMDAVVRRLPGVLNDAQSAEQDSFATGLLDCPHYTRPEVFDGVRVPDVLLSGNHAEIAKWRLKMALGRTRERRPDLLANRQLTKQEARLLAQYQQEHAPDNNRSSS | Specifically methylates guanosine-37 in various tRNAs. | C1DBG0 |
D5CDA0 | AAEB_ENTCC | p-hydroxybenzoic acid efflux pump subunit AaeB | Enterobacter cloacae complex | MGIFTIASQHIRFAVKLASAIVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIIGTFIGCIAALTIIILMIRTPLLMVLVCCIWAGFCTWLSSLVKVENSYAWGLAGYTALIIVITIQTEPLLAPQFAVERCSEIVIGIVCAIVADLLFSPRSIKQEVDRELDALIVSQYQLMQLCIKHGDSEEVDKAWSGLVRRTQALEGMRSNLNMESSRWARANRRLKAINTVSLTLITQACETYLIQNTRPESVTDTFRELFAEPVETVQDVHKQLKRMRRVIAWTGERDTPVTIYTWVGAATRYLLL... | Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. | D5CDA0 |
C4K7H1 | GUAA_HAMD5 | Glutamine amidotransferase | Candidatus Hamiltonella | MIKNIDRHRILILDFGSQYTQLLARRIREMGVYSELWPWDVAAERIQAFHPQGIILSGGPESATENDTPRAPDIIFTLGVPVLGICYGMQTMAIQLGGTVSNTHQGEFGYAPLALKNKNALIDGLEDFVNANNEPCLKVWMSHADKVTKLPEHFTCIASTETCPIAIMAHPEKHFYGVQFHPEVTHTLQGQSLLKRFVLQICQCEPLWTPRNIIDQTLSELKDQIGDDQVILGLSGGVDSAVTAILLHRAIGKSLTCVFVDNGLLRLNESQQVLNIFQDQFGLNIIHVSAANRFMNALKGIQDPEKKRKVIGRVFVDIFD... | Catalyzes the synthesis of GMP from XMP. | C4K7H1 |
B7HBC4 | GLGA_BACC4 | Starch [bacterial glycogen] synthase | Bacillus cereus group | MNILFAVSECVPFVKSGGLADVAGALPKELKKLGVDVRIILPNYSLIPQKLRDGCTLHKVINVPLGWRNQYCGILKGEQDGITYYLIDNEYYFKRDSLYGHYDDGERFSYFSKAVLECIPHLDFEVDVLHSHDWHTAMVNFLLREKYQDNPLYERIKTVYTIHNLQFQGVFPPEVMYDLLELGDEYFHSKQLEFYGNVNFMKGGIIASDQITAVSPTYKEEIQYEFFGEKLDGLLRKYNDKLSGIVNGIDTSVYNPETDSYIKAQYDAESLYEKSENKRALQRYFGLPEKEDTPIISMVTRLTKQKGLDLVRTVFREIME... | Synthesizes alpha-1,4-glucan chains using ADP-glucose. | B7HBC4 |
C4QV17 | GSM1_KOMPG | Glucose starvation modulator protein 1 | Komagataella | MTKPLPLEVKRSRRPTSRACKFCHFKHLQCDATRPCKNCVKRNIGDSCEDIQRRKYGSNGTKKRAQSAQKVQSDSPSASSATNAGTSAVNESKLESSELPMVAQQTQQTPRGLETIPTIPHPNAENNSSFLSPTTSQMFNTGSNTLMDQLKMSVPENNSMYQHDTLFQPPKKYENNSYGYVNAAPQGQHMFYVGYSEPGEQRASPDAEKEPGTNLNSPSSYLSQYSHTQSHTNSQLTNSPSVVYESEIAKQEELQLTSFVEAANNEELDFFDMDFTQRPFIRLLENNTMVSSYPNNSTPKFFDHSRSHGRIPNTAKEVPT... | Transcription factor which regulates nonfermentable carbon utilization. | C4QV17 |
A9VSA7 | ATPF_BACMK | F-type ATPase subunit b | Bacillus cereus group | MPTLLLGASIPFGTIAYTLFIFLLLLVMLRKFAWGPLMGIMKEREEHVTNEIDAAERSNAEAKKLVEEQREMLKQSRVEAQELIERAKKQAVDQKDVIVAAAKEEAESIKTSAVQEIQREKEQAIAALQEQVASLSVHIASKVIEKELKEEDQVKLIRDYIKEVGEAR | Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). | A9VSA7 |
Q8RLW0 | SERC_XENNA | Phosphohydroxythreonine aminotransferase | Xenorhabdus | MNQVYNFSAGPAMLPAEVLRRAEQELCNWHGLGTSVMEISHRSKEFIAVAAEAEKDLRDLLAIPENYNVLFCHGGARGQFSALPQNLLGDKSTADYIVSGYWSECAAKEAEKYCTPNIIDIRSNTDGITSVKPMNEWALSSDAAYVHYCPNETIEGTAIFEEPDFGDDKIVIADYSSTILSAPIDVSRYGVIYAGAQKNIGPAGITVVIIREDLLGKAHKHIPSILDYTVQVKADSMYNTPPTFAWYLSGMVFKWLKEQGGLQEISKRNLAKAELLYRAIDNSNLYINRVALQNRSIMNVPFQLVNPALDGKFLEEAYAH... | Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. | Q8RLW0 |
B5XU34 | UPPP_KLEP3 | Undecaprenyl pyrophosphate phosphatase | Klebsiella | MSDIHSLLVAAILGVVEGLTEFLPVSSTGHMIIVGHLLGFEGDTANTFEVVIQLGSILAVVVMFWRRLFGLIGIHFGRPPEHEGKGSGRLSLIHILLGMIPAVVLGLIFHDTIKSLFNPVNVMYALIVGGVLLIAAEVLKPKQPRAVGIDDMTYRQAFVIGCFQCLALWPGFSRSGATISGGMLMGVSRYAASEFSFLLAVPMMMGATVLDVYKSIGFLNMGDVPMFAVGFVMAFIVALIAIKTFLQLIKRISFIPFAIYRFIVAAAVYVVFF | Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin. | B5XU34 |
Q5F5W5 | FABZ_NEIG1 | Beta-hydroxyacyl-ACP dehydratase | Neisseria | MDVQLPIEAKDIQKLIPHRYPFLQLDRITAFEPMKTLTAIKNVTINEPQFQGHFPDLPVMPGVLIIEAMAQACGTLAILSEGGRKENEFFFFAGIDEARFKRQVIPGDQLVFEVELLTSRRGIGKFNAVAKVDGQVAVEAVIMCAKRVV | Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | Q5F5W5 |
A3LVX1 | TPC1_PICST | Mitochondrial thiamine pyrophosphate carrier 1 | Scheffersomyces | MESRKREDHLRKGSEVSPYESLLAGSISGAVARAVTAPLDTIKIRLQLQRSAFRSRVSVTTVVKDLLKNEGAIALWKGNVPAEILYVLYGAAQFTTYSSISRWLSHLSDTSGFNLPSSAHSLVSGTGAGVVSTLVTYPFDLLRTRLAANSEKKLLSMSGTAREIISSEGFTGLFAGIKPAMLSISTTTGLMFWSYELVRETLGDRDIPFKEGICGFIAGATSKGITFPLDTIRKRTQMYKILYNSAKRVGAFRLLADIVANEGVLGLYKGFGISVLKTSPTSAVSLFVYEYSLAAIQRINRKTLD | Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria. | A3LVX1 |
Q8XZJ3 | GLND_RALSO | [Protein-PII]-UMP uridylyl-removing enzyme | Ralstonia | MHTAAAATPATSPRDILKAERAHLFAQFEQHANVNLLVTKLARAVDQALILLWQDEGMPDTCALVAVGGYGRGELFPHSDVDILLLLPQTADKALETRLEAFIGHCWDMGLDIGSSVRTVDECISEATQDVTVCTSLLEARLLTGDEGLYRTFETHYQGHLDAADFYQSKMLEMRQRHAKYQDTPYSLEPNCKESPGGLRDLQVILWMTRAAGFGSSWNELLVNQLLTRREAKELAANERLLKTIRARLHLLAGRRQDVLVFDLQTQLGEAFGYRPNAAKRTSEQLMRRYYWAAKAVTQLNTVVLQNIEARLFPTELGIT... | Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine ... | Q8XZJ3 |
Q66G56 | MURI_YERPS | Glutamate racemase | Yersinia | MATKPQDANTTSREAITSKADSPPRPTALIFDSGVGGLSVYQEIRQLLPNLHYIYAFDNVAFPYGEKSGEFIVERVLEIVTAVQQSHPLAIVVIACNTASTVSLPALRERFAFPVVGVVPAIKPAVRLTRNGVVGLLATRATVHASYTLDLIARFATDCKIELLGSSELVEVAETKLHGGVVPLEVLKKILHPWLSMREPPDTIVLGCTHFPLLTEELAQVLPEGTRMVDSGAAIARRTAWLISSQENVISSQDENIAYCMALDEDTDALLPVLQSYGFPKLQKLPI | Provides the (R)-glutamate required for cell wall biosynthesis. | Q66G56 |
Q36201 | CYB_UROBI | Ubiquinol-cytochrome-c reductase complex cytochrome b subunit | Uroderma | MTNIRKTHPLLKIINSSFVDLPAPSSLSSWWNFGSLLGVCLGVQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWLLRYLHANGASMFFICLYLHVGRGLYYGSYTYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFLLPFIVTALVMVHLLFLHETGSNNPTGIPSDSDMIPFHPYYTIKDILGFLIMLTALSSLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIVPILHVSKQRSMMFRPL... | Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is... | Q36201 |
Q20X63 | TOLB_RHOPB | Tol-Pal system protein TolB | Rhodopseudomonas | MSSRLPALPLSRRQALLGGAGSAAALLLPGGAQAQTRLQITEGNVAPMPIAIPNFVAGTPADNEVGLGVAQVITNNLKRSGLFAPIDQAAFIERISNIDTPPQFQSWKTINAQALVTGRMTKQGDGRLKAEFRLWDVAAGQQLTGQQYFTSPEYWRRIAHIISDQIYERLTGEKGYFDSRVVFIDETGSKERRVKRLALMDQDGANVRYLTRGADLVLTPRFSPSTQEITYMEFGQGDPRVYLFNIETGQREIVGNFPGMSFSPRFSPDGQRVIMSLQQGGNSNLFVMDLRSKSTTRLTDTPAIDTSPSYAPDGSKICFE... | Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. | Q20X63 |
Q5LNX9 | COXZ_RUEPO | Cytochrome c oxidase assembly protein CtaG | Ruegeria | MALNGPQKTVVQLVSVVVVMGGLAWASVPFYDWFCRVTGFGGATGVAEAGSDTILDKTIKVRFDASKERGMPWEFRPVQTEMELRIGETGLAFYEAYNPTDRPVAGQASYNVAPYSAGGYFDKIACFCFEEQVLQPGERVQMPVTFFVDPEIVNDRDAKYVHTITLSYTFYEIDLPEGYAALDAGEKTNTN | Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. | Q5LNX9 |
A3N0D6 | PYRD_ACTP2 | Dihydroorotate oxidase | Actinobacillus | MYSLIRKCLFSMDAETAHNFSIQALKLAGKLPINVLPMPLNPVEVMGLQFKNPIGLAAGADKNGEAIDGFGKLGFGFIEVGTVTPVAQDGNPKPRQFRILEAEGIINRNGFNNLGVDVLVENVKKAKYDGIIGINIGKNAVTPIERALDDYQICLRKVYEHADYITVNISSPNTKNLRTLQYGEALDDLLRSLKSEQESLSQKFNRYKPLVLKIAPDLTDEEIASVADSLVRYKIDGVIAGNTTLSRDPVVGLKNAEQQGGLSGKPLNTLSTRLISTLAKELNGALPIIGSGGIHSVASGQEKIDAGASLLQVYSAMIYQ... | Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | A3N0D6 |
B9LAA1 | GLMU_NAUPA | Glucosamine-1-phosphate N-acetyltransferase | Nautilia | MLQIIILAAGKGTRMKSSTAKVLHKLCGKSMIEYIIEESLKLTPNIDIVLNHQFEKVSETVKNYPVNIVKQDLEKFPGTGGALKEVPIKGDKVLILNGDMPLIKAEELKKFEELDADIVMSVMKLDNPDGYGRVVIENGNVKKIVEQKDANEEELKIPYVNAGVYLFKKDVLNKYLPKLSNNNSQKEYYLTDIIEMVEKDGLTIKAIEVDEENFKGVNSKKDLAHAEEIMCERIKNFWMQNGVIMHLPETIYIDAYSSFEGECEIGNGCVIKKSVIIESEVRALSVVEEAVIKNSGIGPMARIRPKSELVNTHIGNFVEV... | Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted ... | B9LAA1 |
Q9PA81 | NUSG_XYLFA | Transcription termination/antitermination protein NusG | Xylella | MKRWYVVHAYSGFEKSVAQALRDRISRIEIQDRFGDVLVPAEEVVEMRSGQKRRSEHKFFPGYVLIQIETYYEGGVPRIDNECWHLVKETPKVMGFIGGTADRPLPISSDEADAILRRVQDGAEKPRPKVLFEPGQMVRVIDGPFNDFDGLVEEVNYEKNRLRVAVLIFGRPTPVDLEFGQVQKS | Participates in transcription elongation, termination and antitermination. | Q9PA81 |
Q85B66 | T214A_ANTAG | Translocon at the inner envelope membrane of chloroplasts 214 | Anthoceros | MITSITLLFSILWAQILSWISISGPLILFGLYYGFSITLPMGPSQILSIRAFLLEGNLSGLMALGGSTLGQLIILISIFYSPLYIMLLKPHAITLITLPYVLFYWYEIKDLSDYQPLRPITSLNDTGIIQIFLNSFLFQIFNPILLPSPVLTRLVKLFLFRYSHNSFFVISLFCGWLGGNILLINLSKFLLIRIKNNSSTLYLLVKRLIYRTFSIIIFVACLSYLGKFPVPFSMKKSSDESSLNEWKAERLSWLYKPWPTSLFNYRKWNRPLRYIENSRFSNKSPVKRNVSQYFFDVCLNDGRQRISFTSLPSFSIFEKN... | Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope. | Q85B66 |
Q03IV3 | RS6_STRTD | 30S ribosomal protein S6 | Streptococcus | MAKYEILYIIRPNIEEEAKNALVARFDSILTDNGATVVESKDWEKRRLAYEIQDFREGIYHVVNVEANDATALNEFDRLSKINGDILRHMIVKLDA | Binds together with S18 to 16S ribosomal RNA. | Q03IV3 |
Q3KLH5 | RS3_CHLTA | 30S ribosomal protein S3 | Chlamydia | MGQKGCPIGFRTAVTKKWRSLWYGNNQEFGKFLIEDVKIREFLKKKPSCQGAAGFVVKRMSGKIEVTIHTARPGLVIGKKGAEVESLKAELKKLTGKDVWVEIAEVKRPELNAQLVADGIAKQIERRVSFRRAMKKALQSVMDAGALGVKVQVSGRLAGAEIARSEWYKNGRVPLHTLRADIDYATASAETTYGIIGIKVWINLSEKKAVPAANHAGAASTAAA | Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. | Q3KLH5 |
Q9XV46 | MOE3_CAEEL | Maturation oocyte expansion protein 3 | Caenorhabditis | MSKVKGDLEKSDKRPPSSMSTGSADSGVFSSGVHASSPSHSQGSSSQSGPPSPTTQLNSLLFETANLIAVNEQLRKEIAENKQIQTNQMRALRYSSNPVDQPFVANSISPHHGFPQRPPRGERRMQKPESYKTVICQAWLESKTCTFAENCRFAHGEEELRPAKLESRQNNKYKTKLCDKYTTTGLCPYGKRCLFIHPDNQPNAYIRADKLYEVSQRHALADLRDHVESQIMTGNTRNSYNQQPPPMGGLEMQSSPMKSSSDSSHMRSPMAQMNCETTRPHPSWPLESSSFFLPPEMSSINNNNLMSPFETPFPNGSTGI... | Zinc-finger protein that may play a role in oocyte maturation and fertility. | Q9XV46 |
B0Z4P6 | PSAJ_OENAR | PSI-J | Oenothera | MRDLKTYLSVAPVLSALWFGALAGLLIEINRFFPDALTFPFFS | May help in the organization of the PsaE and PsaF subunits. | B0Z4P6 |
Q5ZLL7 | WDR91_CHICK | WD repeat-containing protein 91 | Gallus | MAAATERTDELVREYLLFRGFTAALKQLDAEIKADREKGFRVDKIVEQLQQFVQSYDLAALRDYWGYLDRRLFSRLEDMYRPTVNKLKTSLYRYYLVHTVQTGRNDKAQEFFLKQASELQNQAEWKDWFVLPFLPAPDSNPTFATYFSRQWADTFIVSLHNFLSVLFQCMPVPVILNLEAECHRSSLIQEENESLRHKLFALQAESSRMKKEELEVEEAVVHHKLPAYVANMDRLGDSELDMTCSQRSTAHSLQSRGGFLSSLLSQSKKGPARPAQPSGASPTQTGSVLLGKKEPANHQSAKGKEGTASSKDGKSHFSGL... | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. | Q5ZLL7 |
A9N278 | ASTC_SALPB | Succinylornithine aminotransferase | Salmonella | MSLSVTRENFDEWMVPVYVPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPALREALNEQANRFWHTGNGYTNEPALRLAKKLIDATFAERVFFCNSGAEANEAALKLARKYAHDRIGNHKSGIVAFKNAFHGRTLFTVSAGGQPSYSQDFAPLPPDIRHAAYNDLNSASALIDDNTCAVIVEPVQGEGGVIPATKAFLQGLRELCDRHQALLIFDEVQTGVGRTGELYAYMHYGVTPDILTTAKALGGGFPIGAMLTTQDYASVMTPGTHGTTYGGNPLATAVAGKVLDIINTPEMQNGVRQRHDAFIERLN... | Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. | A9N278 |
Q37411 | COX2_PATPE | Cytochrome c oxidase polypeptide II | Patiria | MANWTQLGLQDASSPLMEELIYFHDYTLIILTLITILVFYGLASLLFSSNTNRFFLEGQGLETVWTIIPAVILIFIALPSLQLLYLMDEVNNPYLTIKAIGHQWYWSYEYADYRELEFDSYMIPTSDLTSGNPRLLEVDNRLTLPAQTPIRVLVSSADVLHSWAIPSLGIKMDAVPGRLNQVNFFISRCGLFYGQCSEICGANHSFMPIVIESVNFSTFETWVSNFITE | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CII... | Q37411 |
Q3YZ11 | HCAD_SHISS | 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component | Shigella | MKEKTIIIVGGGQAAAMAAASLRQQGFTGELHLFSDERHLPYERPPLSKSMLLEDSPQLQQVLPANWWQENNVHLHSGVTIKTLGRDTRELVLTNGESWHWDQLFIAIGAAARPLPLLDALGERCFTLRHAGDAARLREVLQPERSVVIVGAGTIGLELAASATQRRCKVTVIELAATVMGRNAPPPVQRYLLQRHQQAGVRILLNNAIEHVVDGEKVELTLQSGETLQADVVIYGIGISANEQLAREANLDTANGIVIDEACRTCDPAIFAGGDVAITRLDNGALHRCESWENANNQAQIAAAAMLGLPLPLLPPPWFW... | Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. | Q3YZ11 |
Q8L7U4 | P23A_ARATH | p23 co-chaperone | Arabidopsis | MSRHPEVKWAETTEKIFLTVVLADTKDTKVNLDPEGVFDFSAKVGPENHVYELKLELADKVNVEESKINIGERSIFCIIEKAEPERWNKLLRVKKPPHYVKVDWDKWVDEDDEGSAGAADMDMAGMEGMGGMGGMGGMGGMGGMGGMGGMGGMEGMDFSKLMGGMGGMGGMGGLEGLGGMGGMGGMGGMGGMGGMEEFEDSDDEEETAKSGDKKDDAVKEEGLATEKAPAAEETTSVKEDK | Acts as a co-chaperone for HSP90 . Controls root development through the modulation of auxin distribution in the root meristem . | Q8L7U4 |
P34079 | TX22A_PLETR | Toxin PLTX-2 | Plectreurys | ADCSATGDTCDHTKKCCDDCYTCRCGTPWGANCRCDYYKARCDT | Toxin that inhibits presynaptic voltage-gated calcium channel (Cav) in Drosophila nerve terminals, most likely through specific block of the Cav2 channel (known as Dmca1A). | P34079 |
Q5U4V2 | HNMTA_XENLA | Histamine N-methyltransferase A | Xenopus | MDSKLRSLLSDHSRYVESFRLFLQNSTEHQCMQHFIESKLPNIISSIGNDKPVIDVLGVGSGSGEIDLQMIAKIQARWPGVPINNQIVEPSAEQIFGYKERVAKAPNLENVTFSWHRQTSSEFESQVNEDKQMRKFDFIHMIQMLYYVKDVLGTLKFFKSCLAPSGKLLIILVSGNSGWATLWKKYGQRLPLNDLCLYITAGDIAEMLSSMGARFQSHELQSDMDITECFIEGDRDGELLLDFLTETCDFKRNAPADLRDQIICDLKSPGCSTTKDGKVIFNNNLSVIVVEAD | Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. | Q5U4V2 |
Q5ZHW7 | ABITM_CHICK | Protein Simiate | Gallus | MAAAEALGAARYFTRWYKADVKGRPCEDFCVLQHSNRICVITLAEAHPLLQPGKTITSINYQISPNCSRLQNKVSGKSKRGAQFLTELAPLCRIASSDGEEYTIYSFIRGRLIEVNENILSNPALLQEKPSTEGYIAVVLPKFEESKSVTQGLLTPEEYKEVLLKRQNSSSGS | Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons. | Q5ZHW7 |
Q84FI0 | DPS_KLEPN | DNA protection during starvation protein | Klebsiella | MSTAKLVKSKATNLLYTRNDVADSEKKATIELLNRQVIQFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTALTEHLDTMAERAVQLGGVALGTTQVINSKTPLQSYPLDIHHVQDHLKALADRYAVVANDVRKAIDEAKDEDTADIFTAASRDLDKFLWFIESNIE | During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydr... | Q84FI0 |
A6VJM9 | DAPA_METM7 | 4-hydroxy-tetrahydrodipicolinate synthase | Methanococcus | MQGVYPAIITPFKDGKVDYDGLQSNLDFLIENGVSGVIPVGTTGESPTLTPLEHEQVIEKVVEFVDGRVEVIAGTGSNSTSEALEFSQYAEDVGVDGVLLITPYYNKPSQEGLKRHFGEIANSINVPIVLYNVPSRTALNIEPYTIKYLFEEYSNITAIKEANPNLSQVSEVLDSCNIDVLSGNDELTLPIISLGGKGVVSVVANIAPKEFVQMVDFANAGKFDKAKEIHYKLFPLMKLMFIETNPIPIKTAMNMLGMPSGELRLPLCEMAESNKSKLQNALNNLGLLK | Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | A6VJM9 |
A1T026 | TRHO_PSYIN | tRNA hydroxylation protein O | Psychromonas | MSNTVVCALYRFVSLENYQEIQAPLLKMMQANNIKGTLLLAQEGINGTVAGSREDINTLIAWLKSDPRLNKLTTKESFTEENPFYRTKVKLKKEIVTMGVEGIDPKRTAGSYVKPKDWNALISDPDVLLVDTRNDYEISIGTFKNAVDPKTTNFREFPQYVKDNLDPAVNKKVAMFCTGGIRCEKSTAYLKEQGFDEVYHLEGGVLKYLEEVPQEESMWQGECFVFDNRVSVNHKLEKGQYDQCHGCRLPITEDDKKSDKYQEGVCCHQCHEQLTVEQKQRFAQREKQVGLAKQRGQTHIGNDAVAQLENNRLKKQAVKQ... | Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. | A1T026 |
Q8XDZ5 | ARNC_ECO57 | Undecaprenyl-phosphate Ara4FN transferase | Escherichia | MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHILVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREYGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKE... | Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. | Q8XDZ5 |
Q02788 | CO6A2_MOUSE | Collagen alpha-2(VI) chain | Mus | MTTIKMLQGPLSVLLIGGLLGVLHAQQQEAISPQEQEAVSPDISTTERNNNCPEKADCPVNVYFVLDTSESVAMQSPTDSLLYHMQQFVPQFISQLQNEFYLDQVALSWRYGGLHFSDQVEVFSPPGSDRASFTKSLQGIRSFRRGTFTDCALANMTQQIRQHVGKGVVNFAVVITDGHVTGSPCGGIKMQAERAREEGIRLFAVAPNRNLNEQGLRDIANSPHELYRNNYATMRPDSTEIDQDTINRIIKVMKHEAYGECYKVSCLEIPGPHGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGF... | Collagen VI acts as a cell-binding protein. | Q02788 |
Q9H741 | SPRNG_HUMAN | SREBF pathway regulator in Golgi 1 | Homo | MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQEERAVRDRNLLQVHDHNQPIPWKVQFNLGNSSRPSNQCRNSIQGKHLITDELGYVCERKDLLVNGCCNVNVPSTKQYCCDGCWPNGCCSAYEYCVSCCLQPNKQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA | Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP. | Q9H741 |
Q4WLN1 | ACON_ASPFU | Homocitrate dehydratase | Aspergillus subgen. Fumigati | MISTRLARAGALAPKSRLFLGTRAFATVGDSPLDKKVEMANTEKGNYINYKKMSENLDIVRRRLQRPLTYAEKVLYSHLDDPHGQEIERGKSYLKLRPDRVACQDATAQMAILQFMSAGMPSVATPTTVHCDHLIEAQVGGDKDLARANEINKEVYDFLASATAKYNIGFWKPGSGIIHQIVLENYAFPGGLMIGTDSHTPNAGGLAMAAIGVGGADAVDVMAGLPWELKAPKVIGVKLTGEMSGWTTPKDVILKVAGLLTVKGGTGAIIEYHGPGVTSLSCTGMGTICNMGAEIGATTSMFPFNDRMYDYLKATKRQHI... | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, a step in the citric acid cycle. Also catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. | Q4WLN1 |
A6WTS3 | ARGC_SHEB8 | N-acetyl-glutamate semialdehyde dehydrogenase | Shewanella | MKNIAIIGASGYTGAQLTALIHAEAELTIQGLYVSENSLDKGKPLADLYPSYSHIALTLSPLSDDAKAKIVAEADAVVLATEHSVSLHLAAWFYSQGLAVFDLSGAYRFSDVAQYPKWYGFEHEYPEVLAKAVYGLAEWNAKEIAATKMIAVPGCYPTASLTALKPLASLLTSAYPVINAVSGVTGAGRKAQLQTSFCEVSLTPYGVLGHRHQPEIATQLGQEVIFTPHLGNFKRGILATITVQLKPGTTTADVAAAYSVYDQAPLVTVKHNHFPKVDDVVLTPNCHLGWKFDENSGYLVVASAIDNLMKGAASQALQCI... | Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. | A6WTS3 |
B0VMD7 | THIC_ACIBS | Thiamine biosynthesis protein ThiC | Acinetobacter calcoaceticus/baumannii complex | MNQLTNLSSAEISAQHEQDAKDLTRILPASKKVYIEGSRPDIQVPMREISLTDTPTGLGGEHNPPIMVYDTSGVYTDPNVQIDLNKGLPSVRQKWIEERNDTDVLSGLTSKFGQERLKDIRTADIRFAHIQNPRRAKAGKNVTQMHYAKQGIITPEMEYIAIRENQRQHEAVDMRQHPGQNFGAKNLKEITPEFVRQEVAEGRAIIPANINHPELEPMIIGRNFLVKINANIGNSALGSSIDEEVAKMTWATRWGADTIMDLSTGKNIHETREWIIRNSPVPIGTVPIYQALEKVDGVAENLTWEIFKDTLIEQAEQGVD... | Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | B0VMD7 |
Q6D8J9 | FETP_PECAS | Probable Fe(2+)-trafficking protein | Pectobacterium | MSRTIFCTVLQRDAEGQDFQLYPGDLGKRIYNEISKEAWAQWQTKQTMLINEKKLSMMNVDDRKLLEQEMIKFLFEGKDVHIEGYTPPSH | Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. | Q6D8J9 |
Q811B1 | XYLT1_MOUSE | Xylosyltransferase I | Mus | MVAAPCARRLARRSHSALLAALMVLLLHTLVVWNFSSLDSGAGEQRRAGAAAGAAEQQQPAAPRRERRDLAAHLPAARGGPGGRAGGGGARGGGPGGARAQQPASRGALASRARDPQPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPELAKKPPSRQKEHLQRKLDALDKRQGQSVLGKGPKEVLPPREKATGNSSQGKDLSRHSHARKSGGGGSPETKSDQAPKCDISGKEAISALTRAKSKHCRQEIAETYCRHKLGLLMPEKVARFCPLKGKAHKNVQWDEDAVEYMPANPV... | Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal maturation of chondrocytes during bone development, normal onset of ossification and normal embry... | Q811B1 |
B1KWN1 | RNH2_CLOBM | Ribonuclease HII | Clostridium | MNLNNLENIRYNEIKEFSDKIKKEFTFSQEKQVMDIIEKLNKDPRKNVIKLGQALEKFLNKYEEELKRTNNMYNFDRRYGNNYLIAGVDEVGRGPLAGPIVAAAVVLDLNVEEMQRIFNIKDSKKLSEKKREELDIIIREKAISYNIALVDNKTIDERGISWSNNEVLKRAVEGLKVKPDLVLSDGYAVKNLNIRNEFIIKGDSKSISIASSSIIAKVYRDNMMKEYSKELNMYGFNHNAGYGTEEHVQAIKKYGPSKIHRMSFLTNIL | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | B1KWN1 |
C0NL63 | ARO1_AJECG | Shikimate dehydrogenase | Histoplasma | MGVPTKISILGRESIVADFGIWRNYVAKDLLSSCSSSTYILISDTNLTPLYLEGFQRSFEDAATNVSPKPRLLTYEIPPGESSKSRETKADIEDWMLARQPPCGRDTVIIALGGGVIGDLIGFVAATYMRGVRFVQVPTTLLAMVDSSIGGKTAIDTPNGKNLIGAIWQPQRIYLDMEFLNTLPEREFINGMAEVIKTAAISSDEKFAALERDAETILAAVKSKNTPERPRFSGIEETLKRTILSSAEFKAQVVSADEREGGLRNLLNFGHSIGHAIEAILAPQVLHGECVSIGMVKEAELARHLGILNNVSVSRISKCL... | The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. | C0NL63 |
Q70XJ0 | NU4LM_RHYRA | NADH dehydrogenase subunit 4L | Rhyncholestes | MTTIYLNLILAFTLALSGVLIYRSHLLSTLLCLEGMMLSLFILMALTISHFHMFSLSMAPLILLVFSACEAGVGLALLVKTSNAHGNDHVQSLNLLQC | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. | Q70XJ0 |
Q00941 | CSF2R_MOUSE | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha | Mus | MTSSHAMNITPLAQLALLFSTLLLPGTQALLAPTTPDAGSALNLTFDPWTRTLTWACDTAAGNVTVTSCTVTSREAGIHRRVSPFGCRCWFRRMMALHHGVTLDVNGTVGGAAAHWRLSFVNEGAAGSGAENLTCEIRAARFLSCAWREGPAAPADVRYSLRVLNSTGHDVARCMADPGDDVITQCIANDLSLLGSEAYLVVTGRSGAGPVRFLDDVVATKALERLGPPRDVTASCNSSHCTVSWAPPSTWASLTARDFQFEVQWQSAEPGSTPRKVLVVEETRLAFPSPAPHGGHKVKVRAGDTRMKHWGEWSPAHPLE... | Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. | Q00941 |
P25369 | LSB5_YEAST | LAS seventeen-binding protein 5 | Saccharomyces | MGFLSDHPHTAITETIFRIVSSRDYTLEVELAPLIQLIKADHNDYNYTVNQEEAARALRKKIKYGNRLQQSRTLDLLDLFISQGVKFTVMYNDDKLLQRLRGMATNSENSGSGEKYEPRIIKKCAAYAISWLNYITQNNLENARAYSGLYQLGQTVKQRYSKSSRSRRSGGGSGGRSNFMDDSADDTLYQSNSLTSADRLYRIPQINMNKEAPRIRLIISDALASAVSLQNSLIGLPKGKFSTDDEEATSKFIQARAIRRKVLRYLQLVTEGEFLGSLIHANDELVAALTAYDDRSAQDDSSDESDHGSYDDGIYDENEQ... | Essential for the organization of the actin cytoskeleton, fluid phase endocytosis and vesicle trafficking, together with YSC84. | P25369 |
Q9UT81 | UBX3_SCHPO | Meiotically up-regulated gene 39 protein | Schizosaccharomyces | MDREDILKEFCNRNNIDVSQGRFFLESTNWNYELATALLHEVIPPEEDHGLQPSSDVSKVPEVTGSSSGISGGDQQPPRPLQRQQNTQGQGMKSGTASKKFATLRDLEGNDESAEEKSHLFTGGEKSGLSVEDGDPDPKKQLVRDILEKARQHTISPLDEQDSGPSSLASSWASVGQRLGTENEASGSTTPVTQSGPPRENPPTESQPEKPLRRTLYFWRNGFSVDDGPIYTYDDPANQEMLRYINSGRAPLHLLGVSMNQPIDVVVQHRMDEDYVAPFKPFSGKGQRLGSTYMQPRMSQMPGGLYTDTSTSSSVPINVK... | Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway. Involved in delivery of substrates to the 26S proteasome. Also required for membrane fusion and sporulation. | Q9UT81 |
B2KA22 | SERC_YERPB | Phosphohydroxythreonine aminotransferase | Yersinia | MTQVYNFSAGPAMLPVEVLRRAEQELRNWHGLGTSVMEISHRSKEFMQVAEESEKDLRDLLQIPANYKVLFCHGGARAQFAAVPLNLLGDSNSADYIDGGYWAHSAVKEAQKYCTPHVIDVTTHDNGLTGIQPMKQWKLSDNAAYVHYCPNETIDGVAINEQPDFGNKVVVADYSSAILSRPIDISRYGVIYAGAQKNIGPAGLTLVIVREDLLGKAHTALPSILDYKVLADNDSMFNTPPTFAWYLSGLVFKWLKEQGGLGEMEKRNQAKAELLYGAIDRTGFYRNQVAIANRSWMNVPFQMAEASLDKLFLSEAEAQG... | Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. | B2KA22 |
Q8ZU56 | SYM_PYRAE | Methionyl-tRNA synthetase | Pyrobaculum | MAKYVIGSAWPYVQTVPHLGNMIGSVLSADVYARYLRLKGHEVVFVSGSDVHGTPVEVEAIQLGVDPAEYSMKMHAIVAELFKKWNISFDLYTHTHSETHIKFVQDFYLKIYENGYIFTKEDEVPYCPRDKIYLPDRFIIGKCPYCGYERARGDQCENCGRLLDPKQLIEPKCAVCGSKPEWRITKHWYLDLRRLEDRIRKYVEENPHLPPNAKEMSLAMLKEGLRPRAVTRDNKWGIPAPFPGAEGKTIYVWFEAVLGYISAVVEYFKKIGREEEWKRFWLDPETKVVFFVGKDNVPFHVIILPALLLANGGGYVMPTT... | Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Q8ZU56 |
A7NJH1 | LEUD_ROSCS | Isopropylmalate isomerase | Roseiflexus | MHPISIITGRIVALPAHDIDTDQIIPARYLKVTDKSGLAEGLFYAWRFDAEGKPNPDFVLNRPEAQGATILVAGRNFGCGSSREHAPWALQGYGFKAVISPSFADIFRNNALKNGLLTVQTDEETWQQLVSLFEEDPTTEVIIDLATQTVTLPDGRQARFPIDPFTKHCLLQGIDQMGFLLNEEDAISAYESAHPPRVVTTARS | Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. | A7NJH1 |
Q88XW4 | IF1_LACPL | Translation initiation factor IF-1 | Lactiplantibacillus | MAKEDVIEIQGTIKETLPNAMFKVELENGAEILAHVSGKIRMHYIRILPGDKVTVEMSPYDLTKGRITYRFK | One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-... | Q88XW4 |
Q8ZCR0 | HMP_YERPE | Nitric oxide dioxygenase | Yersinia | MLDTQTIAIVKSTIPLLAATGPKLTAHFYERMFKHHPELKNIFNMSNQSSGDQREALFNAICAYATNIENLAALLPTVERIAQKHTSLNIQPEHYPIVGEHLIATLDELFSPGQAVLDAWAKAYGVLADVFIQRESQIYQQSETETGGWRTLRRFRIIKKEQQSEVICSFVLAPEDGGQVLHYKPGQYLGIYIEHESLEFQEIRQYSLTTAPNGKTYRIAVKREEQGTVSNLLHRELNEGDIVRIAPPRGDFFLDVSPDTPVALISAGVGQTPMLSMLNTLYSQQHAAPVHWLHAAENGRVHAFADEVSAIAAKMPNLSR... | Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. | Q8ZCR0 |
Q9WXS4 | UXUA_THEMA | D-mannonate hydro-lyase | Thermotoga | MKLVFRWYGEKHDTVTLEQIRQIPGVEGVVGALFDIPVGEVWPFEEIMKLKETVEKAGLKLEVIESVNVHEDIKLGLPTRDRYIENYKKTIRNLAKAGVKVVCYNFMPVFDWMRTDLHKKLPDGSETMEYDHRLIEGVTPDELIKRVKEGSQGFVLPGWEWDRLEKLRETFELYKNVDEEKLFENLVYFLERVIPVCEECDVKLAIHPDDPPWSIFGLPRIITNKENIERMLKAVDSPYNGITFCMGSLGANPENNIPEMIRYFGKMGRIHFAHVRNLKFTGEKSFYETAHPSFCGSHDLFEVMKAFHDIGYEGYIRPDH... | Catalyzes the dehydration of D-mannonate. | Q9WXS4 |
A6YGC5 | RR19_PLETE | 30S ribosomal protein S19, chloroplastic | Pleurastrum | MSRSLTKGPFIADHLLKKIQKLNAQGKKKVIVTWSRASTIVPLMIGHTIAVHNGREHIPVFITDQMVGHKLGEFSPTRTYRGHIKTKGDKKSKR | Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. | A6YGC5 |
B2FTJ0 | SYI_STRMK | Isoleucyl-tRNA synthetase | Stenotrophomonas maltophilia group | MSQDYKTTLNLPATEFPMRGDLPKREPGILARWEAQGLYQQLRDNAAGRPLFVLHDGPPYANGRIHLGHAVNKILKDIIVKSRYLAGFDAPYVPGWDCHGLPIEIAVEKKWGKVGTKLDAVEFRQKCREFAEEQINIQRVDFKRLGVTGDWDNPYKTLSFDFEANEIRALSKVVANGHLVRGAKPVYWCFDCGSALAEAEIEYQEKESPAIDVAYAARDAQAIGQAFGVSVPADVEVAVPIWTTTPWTLPASLAVSLGAEITYVLAEGPAHNGKRRWLVLAAALAERALQRYGVENLVLHGETTGAALENQLLAHPFYPE... | Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrol... | B2FTJ0 |
P51609 | CCN3_XENLA | Protein NOV homolog | Xenopus | MTPHLALCFILLIQQVASQKCPSQCDQCPEEPPSCAPSVLLILDGCGCCPVCARQEGESCSHLNPCQEDKGLYCEFNADPRMETGTCMALEGNSCVFDGVVYRNRESFQPSCKYHCTCLNGHIGCVPRCNLDLLLPGPDCPFPRRVKVPGECCEKWVCDSKEEMAIGGFAMAAYRPEATLGIDASDTSFACIAQTTEWSACSKTCGMGVSSRVTNRNARCEMQKQIRLCMVRSCEEEPGWHVEKKGKKCVRVRKTTKPIHFHYKNCTSVQPYKPKFCGQCSDGRCCTPHSTKTMHVEFVCPQKRIVKKPVMVISTCVCHY... | Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. | P51609 |
C1BAC2 | ISPD_RHOOB | MEP cytidylyltransferase | Rhodococcus | MAEGRGPVVALVPAAGQGVRLGENKPKAFVDLGGTTMLTRAVDGLLQSGAVDRVVVIVPEELVESTRSLLPGHVTVVAGGSERTGSVRAGLAVADDAEYVLVHDAARALTPPSLIARVVAELRCGRRAVIPVLPVADTIKTVDVLGAVTGTPERSELRAVQTPQGFTAELLRRAYAAADGIATDDAGLVERLGERVRSIVGEPTAFKITTPLDLVLARALVEEGAH | Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | C1BAC2 |
B7L7D0 | SELU_ECO55 | tRNA 2-selenouridine synthase | Escherichia | MQERHTEQDYRALLIADTPIIDVRAPIEFEQGAMPAAINLPLMNNDERAAVGTCYKQQGSDAALALGHKLVAGEIRQQRMDAWRAACLQNPQGILCCARGGQRSHIVQSWLHAAGIDYPLVEGGYKALRQTTIQATIELAQKPIVLIGGCTGCGKTLLVQQQPNGVDLEGLARHRGSAFGRTLQPQLSQASFENLLAAEMLKTDARQNLRLWVLEDESRMIGSNHLPECLRERMTQAAIAVVEDPFEIRLERLNEEYFLRMHHDFTHAYGDEQGWQEYCEYLHHGLSAIKRRLGLQRYNELAARLDAALTTQLATGSTDS... | Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS... | B7L7D0 |
Q8J0F6 | MLCC_PENCI | DihydroML-236B hydroxylase | Penicillium | MLGQVLLTVESYQWVSTPQALVAVAVLLSLIAYRLRGRQSELQVYNPKKWWELTTMRARQDFDTYGPSWIEAWFSKNDKPLRFIVDSGYCTILPSSMADEFRKIKDMCMYKFLADDFHSHLPGFDGFKEICQDAHLVNKVVLNQLQTQAPKYTKPLATLADATIAKLFGKSEEWQTAPVYSNGLDLVTRTVTLIMVGDKICHNEEWLDIAKNHAVSVAVQARQLRVWPMLLRPLAHWFQPQGRKLRDQVRRARKIIDPEIQRRRAEKAACVAKGVQPPQYVDTMQWFEDTADGRWYDVAGAQLAMDFAGIYASTDLFVGA... | Dihydro-ML-236C carboxylate monooxygenase; part of the gene cluster that mediates the biosynthesis of compactin, also known as mevastatin or ML-236B, and which acts as a potent competitive inhibitor of HMG-CoA reductase . Compactin biosynthesis is performed in two stages . The first stage is catalyzed by the nonaketide... | Q8J0F6 |
A4IR02 | END4_GEOTN | Endonuclease IV | Geobacillus | MLKIGSHVSMSGKKMLLAASEEAVSYGANTFMIYTGAPQNTRRKAIEELNIEAGHEHMKAHGIEDIVVHAPYIINIGNTKNPDTFALGVNFLRAEIERTEAIGAKQLVLHPGAHVGAGAEAGLRQIIRGLNEVLTREQTVEIALETMAGKGSECGRTFEELAYIIDGVAYNDKLSVCFDTCHTHDAGYDIVNDFDGVLSEFDRVIGLERLKVLHINDSKNPRGSRKDRHENIGFGHIGFRALNYIVHHPQLADIPKILETPYVGEDKNNKKPPYKHEIAMLRAQTFDDQLLEKIVADTQ | Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. | A4IR02 |
A1R8Y2 | MSHD_PAEAT | Mycothiol synthase | Paenarthrobacter | MSHAHPENWPVLIIAGALDTELLRDVKTLAAAAGESDGNPPFSEQTLVTLRGADAGDHSVLSFVLYAPDEDSDPATAEDLAGVAVVVENGDESGVLELAVHPSYRNQGVAGRLLDALQGKRGLGGLSAWSHGNHEAAAELATRFGYGPVRELWKMRLMSSTSALPDAGLPDGVSLRAFVPGQDEQAWLTANSAAFSHHPEQGSMTRADLEARKAEDWFDPEGFLLAVNAEGELLGFHWTKVHPRQGPHPAIGEVYVVGVTPEAQGLGLGKALTVAGIKHLQDQGLHAVMLYVDADNEAAVALYQKLGFVRWDTDVMYGPL... | Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. | A1R8Y2 |
B3QLJ0 | HIS3_CHLP8 | Phosphoribosyl-AMP cyclohydrolase | Chlorobaculum | MSENQDTQKSFLETVKFDDRGLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWLKGESSGNMQDVHDIMIDCDGDTLLLKVSQKGGACHVGYHSCFYRKTTDGEQMEICDTLMFDPEEVYGKKS | Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | B3QLJ0 |
O88685 | PRS6A_MOUSE | Tat-binding protein 1 | Mus | MQEMNLLPTPESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIVQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQL... | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions ... | O88685 |
P30569 | EC1_WHEAT | Zinc metallothionein class II | Triticum | MGCDDKCGCAVPCPGGTGCRCTSARSGAAAGEHTTCGCGEHCGCNPCACGREGTPSGRANRRANCSCGAACNCASCGSATA | Binds 5 molecules of zinc. May have a role in Zn(2+) homeostasis during embryogenesis. | P30569 |
B2TWI1 | THIC_SHIB3 | Thiamine biosynthesis protein ThiC | Shigella | MSATKLTRREQRARAQHFIDTLEGTAFPNSKRIYLTGTHSGVRVPMREIQLSPTLIGGSKEQPQFEENEAIPVYDTSGPYGDPQIAINVQQGLAKLRQPWIDARGDTEELTVRSSDYTKARLADDGLDELRFSGVLTPKRAKAGRRVTQLHYARQGIITPEMEFIAIRENMGRERIRSEVLRHQHPGMSFGARLPENITAEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSMRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAEDLTWEAFRDTLL... | Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. | B2TWI1 |
B0TE53 | BIOB_HELMI | Biotin synthase | Heliomicrobium | MQSIIRQTEAALFAGAVLDRETAGKLARIEGSDIYTLMDVARRVRDHFGAGKVDLCSIVNAKSGACSEDCRFCAQSAHHQACVKTYDLLDPDAIVGRARVMEAEGAHRFSLVTSGRGMSDAELEPVLAIYERLRRETKLSLCASLGILNEAQLRRLAEAGVTMYHHNLEASRRFFPQICTTHSYDERIATIRAAQAAGMVVCSGGIFSMGETIDDRIDMAFELRELGIRSVPINILNPIAGTPLEGQPLIPPLEILKSIALYRLILPSARIRMAGGREGALRDLQSLPFIAGADAALVGSYLTTSGRTVAEDIQMLRDLG... | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. | B0TE53 |
A0AK94 | LEUC_LISW6 | Isopropylmalate isomerase | Listeria | MGKTLFDKLWNRHVIYGKEGEPQLLYVDLHLIHEVTSPQAFEGLRMENRPLRRPDKTFATMDHNVPTEDIFNIQDLVAKKQIEALQTNCAEFGVTLADMGSDRQGIVHMVGPETGLTQPGKVIVCGDSHTATHGAFGAIGFGIGSSEVEHVFATQTIWQQKPKSMGIEIKGKLPKGVYAKDIILHLIATYGVAFGTGYAVEYYGETIQNMSMEERMTICNMAIEGGAKMGMMAPDETTFEYVRGREYAPTDMEKAISDWKTLQTDPDAEYDLHIEMDASTLEPYVTWGTNPEMGVPFSRAFPEIKDMNYERAYEYMGLKP... | Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. | A0AK94 |
A1QZY4 | DNLJ_BORT9 | Polydeoxyribonucleotide synthase [NAD(+)] | Borrelia | MGRFNVKFMIKDIEDEILCLRDNIRKWNKEYYVDSSPSVSDLTYDKALLRLQDLESKYPEYKTLDSPTLKFGSDLLNNFEEVTHSFPILSLDKAYDIKELLLWIEKMVLEGSSLGSYTGISVEPKIDGCSIVLYYKDGILQKALTRGDGRVGNDVTENVRTIKNVPLSIDEKVELVLRGEIYITKENFLKINHTLKNPYLNARNLASGILRRINSREVASFPLDIFVYDILYSSFGLSTNHDAFDKLKKFGFKINPFCKFFGGKNLEEITNHVKKIEMQRNSLEYEIDGVVLKVDSFILRDILGYTSHHPKWSVAYKFES... | DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | A1QZY4 |
P35394 | TBB_ENTDO | Beta-tubulin | Enteroctopus | MREIVHIQAGQCGNQIGSKFWEVISEEHGIDPSGVYQGKLSTQLERSYVYFNEASSGKYVPRAVLLDLEPGTMDSVRSGPYGSLFRPDNYVFGQSGAGNNWAKGHYTEGAELVDTVLDVIRKECEGCECIQGFQMTHSLGGGTGAGMGTLLISKYREEYPDRIMTTFSVMPSPKVSDTVVEPYNATLSIHQLVENTDETFCIDNEALYDISLRTLKLPNPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQDYRMHSVSDLTQQLFDAKNMMTACDPRHGRYLTVAAVFRGK... | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-... | P35394 |
Q9CV60 | MLN_MOUSE | Myoregulin | Mus | MSGKSWVLISTTSPQSLEDEILGRLLKILFVLFVDLMSIMYVVITS | Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in ad... | Q9CV60 |
B3PJA8 | PIMT_CELJU | Protein-beta-aspartate methyltransferase | Cellvibrio | MTNLLLQGVGMTSLRTRERLIQRLRDQGVTNLRVLDIMLNTPRHLFLDEALAHRAYEDTALPIGHGQTLSQPYIVARMTELLLGAAGKLNKVLEVGTGSGYQTSLLAQLVPEVYTVERIKPLQDKARERLHQLGLRNIRYRHADGGFGWPDMGAYDGILSTAAPQVVPDELLKQLAPGGVLVIPVGGREQQLHLIIRDTEDTEKFVTQILEPVKFVPFLSGTAR | Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. | B3PJA8 |
O28964 | FAEHP_ARCFU | D-arabino-3-hexulose-6-phosphate formaldehyde lyase | Archaeoglobus | MEFRIGEALIGEGFEVAHVDLIIGTKDSPAGIAFANALANLSAGHTPLLAVLRPNLITKPPAVIVPKVTVKDMHQAELIFGPAQAAVAKAVADAVEEGIIPRERADEYVVVASVFIHPNAKNKHKIYYYNYGATKLAIKRAMQNFPDVDTVLYEKDRSFHPFVGRKLTKLWDPPYLQIAIDIPDLGEVLKVLEQIPDSDHIVFEVGTPLAKRYGCEVILKLREVKPDAFYILDLKTLDVGNLEARMAADATANAVVISGLAPTSTIVKGIREAEKTGILSYVDMMNVDDPIKRLEEIQKAGVLPNVVELHRAIDSEDKEP... | Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate. | O28964 |
P73755 | MNMA_SYNY3 | tRNA-specific 2-thiouridylase MnmA | unclassified Synechocystis | MTQKVVVGLSGGVDSSVAAALLHRQGYAVVGVTLWLMKGKGQCCSEGLVDAASICEQLGVPHEIVDTRDLFQNHIIDYLVQGYGEGVTPLPCSQCNKAVKFGPMLQYAQQSLGIDKIATGHYARIRFNEASQRYELLRAVDRQKDQSYFLYDLSQEILAATLFPLGEQTKTVTRQLAAEFDLSTAEKKDSQDLCLIEAHGSMRDFLDKYIAPKAGEIVDLSGAVLGHHEGIHHYTIGQRKGLGIAAAEPLYVVKLDPVMNRVIVGDRQSAGSGECYVQRLNWVSIPEPTAPIRCEVQVRYRSAPVTVNAIPWHDQQIKLV... | Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | P73755 |
C5BF39 | ATPG_EDWI9 | F-ATPase gamma subunit | Edwardsiella | MAGAKEIRSKIASVQNTQKITKAMEMVAASKMRKTQDRMAASRPYAETMRKVIGHLALGNLEYKHPYLEERDIKRVGYLVVSTDRGLCGGLNINLFKKLLTEMKEWNQKGVDIDLALIGSKAVSFFGSVGGNVVAQVTGMGDNPSLSELIGPVKVMLQAYDEGRLDRLYVVSNKFINTMSQEPQVIQLLPLPKADDAELKRKSWDYLYEPDPKALLDTLLRRYVESQVYQGVVENLASEQAARMVAMKAATDNGGNLIKELQLVYNKARQASITQELTEIVSGAAAV | Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. | C5BF39 |
Q6IFW2 | K1C40_RAT | Type I hair keratin Ka36 | Rattus | MASEGSPDCCSSEPYAGASSCTTASFCPTSTTYLPSTCATSRCQTPSFLCRAHLPAGCLSPCYLTGGCNSPCLVGNCAWCEEGTFNSNEKETMQFLNDRLASYLERVRSLEENNAELECRIREQCEPDATPVCPDYQRYFDTIEELQQKILCTKAENSRLAVQVDNCKLAADDFRSKYESELSLRQLVENDISGLRGILGELTLCKSDLEAHVESLKDDLLCLKKDHEEEVNLLREQLGDRLNVELDTAPTVDLNKVLDEMRCQYERVLANNRRDAEEWFAAQTEELNQQQMSSAEQLQGCQTEMLELKRTANTLEIELQ... | May play a role in late hair differentiation. | Q6IFW2 |
A4QKK0 | RBL_CAPBU | Ribulose bisphosphate carboxylase large chain | Capsella | MSPQTETKASVGFKAGVKEYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVPGEETQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALAALRLEDLRIPPAYTKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLSHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRL... | RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. | A4QKK0 |
Q5E6F2 | SERC_ALIF1 | Phosphohydroxythreonine aminotransferase | Aliivibrio | MEKVFNFCAGPAMLPVDVLAQAQKELVNWNGLGTSVMEISHRSKEFIKVAEESEQDLRDLLAIPDNYKVLFCQGGARAQFAAVPLNLLGGNTKADYVDAGYWAQSAVEEAQKYCTPNVINTIIDVDGKKAVQPASEWALSDDAVYVHFCPNETIDGIEINDLPVTDKPIVADMSSTILSRKIDVSKYGVIYAGAQKNIGPAGLTIVIVRDDLLDLASQTLPSVLNYGVLADKESMFNTPPTYAWYLAGLVFKWLKSNGGIDAMETHNRKKAAVLYDYIDQSDFYRNDVHSDNRSLMNVPFQLANPELDTKFLELADEAGL... | Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. | Q5E6F2 |
B2V4F3 | CODY_CLOBA | GTP-sensing transcriptional pleiotropic repressor CodY | Clostridium | MSSLLSKTRRLNKILQKTGTEPVAFQDICTLLSEVLECNAYIVSKRGKVLGYTFSPGFECEAMKKKVIEDKKFPEDYNLTLLESNETLANLSNQGRCVFAEIGDCKTKDKISTIIPIIGSRERLGTLILARFGKEFTDDDLVLVEYSATIVGMEMLRALQEDLADQTRKKAVVQLAIGTLSYSELEAVEHIFEELNGNEGLLVASKIADKVGITRSVIVNALRKFESAGVIESRSLGMKGTYIRVLNEKLLDELKKIK | DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer b... | B2V4F3 |
Q38WK1 | ATPF_LATSS | F-type ATPase subunit b | Latilactobacillus | MFSNLIVGASASYLGDSLFVLVVFIILVALVGKFAFGPVSKMMQERSNKITNDLDSAAQSREDAAKLAAQRATELKSSKSEAVEIVNTAKQNGEKQREGMVTLAQEEVQTLKQNAKKDIEQSRLDALNSARDDVAQLSIEIASKLIKKELSVTDQKSLINSYIEGLDKQNETR | Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). | Q38WK1 |
Q07UH4 | IHFB_RHOP5 | Integration host factor subunit beta | Rhodopseudomonas | MIKSELVQRIAEHNPHLYQRDVENIVNAILEEIVAALARGDRVELRGFGAFSVKHRPARAGRNPRTGEHVPVEQKSVPFFKTGKEMRERLNRDNGISAETGA | This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. | Q07UH4 |
B7LDH3 | UNG_ECO55 | Uracil-DNA glycosylase | Escherichia | MANELTWHDVLAEEKQQPYFLNTLQTVASERQSGVTIYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVRPGIAIPPSLLNMYKELENTIPGFTRPNHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVISLINQHREGVVFLLWGSHAQKKGAIIDKQRHHVLKAPHPSPLSAHRGFFGCNHFVLANQWLEQRGETPIDWMPVLPAESE | Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | B7LDH3 |
Q0C2L6 | CCME_HYPNA | Heme chaperone CcmE | Hyphomonas | MRARTRRLYTFGIAAALIVAAAALAFFALRENANLFYTPEVLAEKGLPREGREVKVGGWVEPGSLTYADGGATMRFTVIDNSPSTITVSFNGVAPDLFREGQGVVATGTFTPEGEFTARQLLAKHDENYQPRELKPLEAGG | Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. | Q0C2L6 |
Q6GJH3 | SP5G_STAAR | Putative septation protein SpoVG | Staphylococcus | MKVTDVRLRKIQTDGRMKALVSITLDEAFVIHDLRVIEGNSGLFVAMPSKRTPDGEFRDIAHPINSDMRQEIQDAVMKVYDEIDEVVPDKNATSEDSEEA | Could be involved in septation. | Q6GJH3 |
O14230 | ERG20_SCHPO | Geranyltranstransferase | Schizosaccharomyces | MSAVDKRAKFESALPVFVDEIVNYLKTINIPDDVTEWYKNSLFHNTLGGKYNRGLSVIDSYEILLGHPLDEAAYMKAAVLGWMVELLQSFFLIADDIMDASKTRRGQPCWYLMPGVGNIAINDAFMVESAIYFLLKKHFRQESCYVDLIELFHDVTFQTELGQQLDLLTAPEDSVDLSKFSLQKHSFIVIYKTAFYSFYLPVALAMHLAGVATPENLKCAQDILIILGKYFQVQDDYLDCYGDPTVTGKIGTDILDNKCSWIINLALAKCTPEQRVILDDNYGRKDSESEKRVKAVFEELNIRGEFENYEESEVSEIKKL... | Farnesyl pyrophosphate synthase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway . Fps1 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product... | O14230 |
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