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"_meta": {
"purpose": "Hand-written retrieval sanity set. Each question lists passage ids that correctly answer it; a hit means one of them is in the top 3. Written from the passage content, then frozen, so it checks retrieval and does not tune it.",
"recorded": "2026-10-01"
},
"tcga-nsclc": [
{
"q": "which features separate squamous from adenocarcinoma of the lung",
"expect": [
"lung-luad-vs-lusc",
"lung-lusc-cytomorphology"
]
},
{
"q": "keratin pearls intercellular bridges",
"expect": [
"lung-lusc-cytomorphology",
"lung-lusc-definition",
"lung-luad-vs-lusc"
]
},
{
"q": "glandular acinar pattern mucin production",
"expect": [
"lung-luad-definition",
"lung-luad-cytomorphology",
"lung-luad-grading"
]
},
{
"q": "how is lung adenocarcinoma graded by pattern",
"expect": [
"lung-luad-grading"
]
},
{
"q": "TTF-1 Napsin A p40 p63 staining",
"expect": [
"lung-luad-ihc",
"lung-lusc-ihc"
]
},
{
"q": "squamous carcinoma subtypes basaloid keratinizing",
"expect": [
"lung-lusc-subtypes"
]
},
{
"q": "lepidic micropapillary predominant pattern subtypes of adenocarcinoma in situ",
"expect": [
"lung-luad-subtypes",
"lung-luad-grading"
]
},
{
"q": "poorly differentiated solid tumour ambiguous morphology what resolves it",
"expect": [
"lung-luad-vs-lusc"
]
},
{
"q": "What growth patterns are recognised in lung adenocarcinoma and how do lepidic, acinar, papillary, micropapillary and solid look?",
"expect": [
"lung-luad-libre-growth-patterns",
"lung-luad-patterns-who-2021-wikipedia"
]
},
{
"q": "What distinguishes lepidic growth from invasive adenocarcinoma in the lung?",
"expect": [
"lung-luad-lepidic-definition",
"lung-luad-libre-extent-classification"
]
},
{
"q": "How is lung adenocarcinoma graded by its dominant growth pattern and what is the 20 percent high-grade rule?",
"expect": [
"lung-luad-grading-who-vs-iaslc",
"lung-luad-grading-iaslc-biopsy-cohort",
"lung-luad-grading-cap-libre"
]
},
{
"q": "Do pathologists agree on the predominant pattern of lung adenocarcinoma?",
"expect": [
"lung-luad-pattern-interobserver-variability",
"lung-luad-pattern-ai-agreement"
]
},
{
"q": "Which nuclear and cytoplasmic features suggest adenocarcinoma of the lung on H&E?",
"expect": [
"lung-luad-libre-microscopy",
"lung-luad-cohort-morphology"
]
},
{
"q": "How common is an acinar component in lung adenocarcinoma and what is its prognosis?",
"expect": [
"lung-luad-acinar-definition"
]
},
{
"q": "What are keratin pearls and intercellular bridges and why do they point to squamous carcinoma of the lung?",
"expect": [
"lung-lusc-keratin-pearls-bridges-review",
"lung-lusc-libre-microscopy",
"lung-lusc-cohort-morphology"
]
},
{
"q": "What is the difference between keratinizing, non-keratinizing and basaloid squamous carcinoma?",
"expect": [
"lung-lusc-subtypes-wikipedia"
]
},
{
"q": "How is squamous cell carcinoma of the lung graded by keratinization?",
"expect": [
"lung-lusc-libre-microscopy",
"lung-lusc-keratinization-grading-cohort"
]
},
{
"q": "Can squamous carcinoma grow under alveolar pneumocytes and look like a lepidic tumour?",
"expect": [
"lung-lusc-subepithelial-growth-mimic"
]
},
{
"q": "What patterns does peripheral squamous carcinoma show and which carries a good prognosis?",
"expect": [
"lung-lusc-definition-pattern-series",
"lung-lusc-subepithelial-growth-mimic"
]
},
{
"q": "How can I tell lung adenocarcinoma from squamous carcinoma on H&E when glands are not obvious?",
"expect": [
"lung-luad-vs-lusc-libre-bridges-mucin",
"lung-luad-vs-lusc-solid-variant-nos"
]
},
{
"q": "When does H&E morphology misclassify lung adenocarcinoma versus squamous carcinoma on a small biopsy?",
"expect": [
"lung-luad-vs-lusc-ihc-reclassification",
"lung-luad-vs-lusc-adenosquamous"
]
},
{
"q": "How do I prove that a solid tumour without glands is adenocarcinoma rather than non-keratinizing squamous carcinoma?",
"expect": [
"lung-luad-solid-mucin-lineage",
"lung-luad-vs-lusc-solid-variant-nos",
"lung-luad-libre-special-stains"
]
},
{
"q": "Is tumour location central or peripheral useful for separating lung adenocarcinoma from squamous carcinoma?",
"expect": [
"lung-luad-vs-lusc-location-clinical",
"lung-lusc-keratin-pearls-bridges-review"
]
},
{
"q": "What are the differential diagnoses listed for lung adenocarcinoma?",
"expect": [
"lung-luad-libre-differential"
]
}
],
"bracs-fine": [
{
"q": "difference between atypical ductal hyperplasia and ductal carcinoma in situ",
"expect": [
"breast-adh-vs-dcis",
"breast-hard-boundaries"
]
},
{
"q": "usual ductal hyperplasia no atypia",
"expect": [
"breast-udh"
]
},
{
"q": "flat epithelial atypia apical snouts calcifications",
"expect": [
"breast-fea"
]
},
{
"q": "loss of myoepithelial layer stromal invasion",
"expect": [
"breast-ic"
]
},
{
"q": "what is in the pathological benign category",
"expect": [
"breast-pb"
]
},
{
"q": "comedonecrosis pleomorphic nuclei high grade",
"expect": [
"breast-dcis-grades"
]
},
{
"q": "cribriform micropapillary monomorphic cells partial involvement of ducts",
"expect": [
"breast-adh-khoury",
"breast-adh-bracs"
]
},
{
"q": "normal breast tissue luminal and myoepithelial cells epithelium to stroma ratio",
"expect": [
"breast-normal"
]
},
{
"q": "how is the whole slide label defined in BRACS",
"expect": [
"breast-wsi-label-rule"
]
},
{
"q": "why are atypical lesions clinically important",
"expect": [
"breast-atypical-significance"
]
},
{
"q": "What does normal breast tissue look like at gland level?",
"expect": [
"breast-n-libre-resting-breast",
"breast-n-bracs-paper-tissue"
]
},
{
"q": "Which cell layers line a normal breast duct and how are they shown by stain?",
"expect": [
"breast-n-myoepithelium-key",
"breast-n-libre-resting-breast"
]
},
{
"q": "How does stroma in normal breast differ from benign pathology?",
"expect": [
"breast-n-vs-pb-ratio-and-glands",
"breast-n-libre-resting-breast"
]
},
{
"q": "What is the ratio of epithelium to stroma in normal versus benign lesion tissue in BRACS?",
"expect": [
"breast-n-bracs-paper-tissue",
"breast-n-vs-pb-ratio-and-glands"
]
},
{
"q": "Which benign lesions are grouped into the pathological benign class of BRACS?",
"expect": [
"breast-pb-bracs-composition"
]
},
{
"q": "What are the H&E features of fibrocystic change?",
"expect": [
"breast-pb-fibrocystic-libre"
]
},
{
"q": "How does sclerosing adenosis mimic carcinoma on H&E?",
"expect": [
"breast-pb-sclerosing-adenosis-libre"
]
},
{
"q": "What distinguishes an intraductal papilloma from papillary DCIS?",
"expect": [
"breast-pb-papilloma-libre",
"breast-dcis-subtypes-architecture"
]
},
{
"q": "What stromal features define a fibroadenoma?",
"expect": [
"breast-pb-fibroadenoma-libre-wikipedia"
]
},
{
"q": "Is fibrocystic change benign or does it imply cancer risk?",
"expect": [
"breast-pb-fibrocystic-libre",
"breast-n-vs-pb-ratio-and-glands"
]
},
{
"q": "How many cell layers does usual ductal hyperplasia have and what do its lumina look like?",
"expect": [
"breast-udh-libre-florid-hyperplasia",
"breast-udh-wikipedia-histology"
]
},
{
"q": "Why is usual ductal hyperplasia not atypical?",
"expect": [
"breast-udh-bracs-and-terminology",
"breast-udh-libre-florid-hyperplasia"
]
},
{
"q": "Which immunostain pattern separates usual hyperplasia from atypical hyperplasia?",
"expect": [
"breast-udh-ck56-er-pattern"
]
},
{
"q": "What risk does usual ductal hyperplasia carry compared with atypical hyperplasia?",
"expect": [
"breast-udh-risk-and-molecular",
"breast-udh-libre-florid-hyperplasia"
]
},
{
"q": "What do columnar cell lesions with atypia look like and how many cell layers are involved?",
"expect": [
"breast-fea-who-definition-ccl-spectrum",
"breast-fea-libre-features"
]
},
{
"q": "How reproducible is the diagnosis of flat epithelial atypia between pathologists?",
"expect": [
"breast-fea-interobserver-variability",
"breast-fea-vs-adh-expert-disagreement"
]
},
{
"q": "What is the difference between columnar cell change and flat epithelial atypia?",
"expect": [
"breast-fea-who-definition-ccl-spectrum",
"breast-fea-libre-features"
]
},
{
"q": "What cytologic features define flat epithelial atypia in the BRACS description?",
"expect": [
"breast-fea-bracs-and-expert-definition"
]
},
{
"q": "What is known about proliferation and upgrade risk of flat epithelial atypia?",
"expect": [
"breast-fea-proliferation-and-risk"
]
},
{
"q": "How do I tell usual ductal hyperplasia from flat epithelial atypia?",
"expect": [
"breast-udh-vs-fea-indirect"
]
},
{
"q": "Is there a direct comparison between usual hyperplasia and flat epithelial atypia in the sources?",
"expect": [
"breast-udh-vs-fea-indirect"
]
},
{
"q": "Which lesion shows streaming multilayered epithelium and which shows monomorphic columnar cells with snouts?",
"expect": [
"breast-udh-vs-fea-indirect",
"breast-udh-libre-florid-hyperplasia",
"breast-fea-libre-features"
]
},
{
"q": "Do usual hyperplasia and flat epithelial atypia differ molecularly or by basal cytokeratin staining?",
"expect": [
"breast-udh-vs-fea-indirect",
"breast-udh-risk-and-molecular",
"breast-udh-vs-fea-ihc-molecular"
]
},
{
"q": "What size limit defines atypical ductal hyperplasia?",
"expect": [
"breast-adh-libre-features-size",
"breast-adh-wikipedia-size-criteria",
"breast-adh-review-morphology"
]
},
{
"q": "What architecture and cells are seen in atypical ductal hyperplasia?",
"expect": [
"breast-adh-libre-features-size",
"breast-adh-review-morphology",
"breast-adh-bracs-definition"
]
},
{
"q": "How often do pathologists disagree on atypical ductal hyperplasia?",
"expect": [
"breast-adh-interobserver-variability"
]
},
{
"q": "What share of atypical hyperplasia on core biopsy is upgraded at excision?",
"expect": [
"breast-adh-risk-upgrade",
"breast-adh-wikipedia-size-criteria"
]
},
{
"q": "Which architectural feature turns a columnar cell lesion from flat epithelial atypia into atypical ductal hyperplasia?",
"expect": [
"breast-fea-vs-adh-architecture"
]
},
{
"q": "Do breast pathology experts agree when flat atypia has focal architectural atypia?",
"expect": [
"breast-fea-vs-adh-expert-disagreement",
"breast-fea-interobserver-variability"
]
},
{
"q": "How many ducts are involved in ADH compared with FEA?",
"expect": [
"breast-fea-vs-adh-architecture",
"breast-adh-review-morphology"
]
},
{
"q": "Is flat epithelial atypia always flat?",
"expect": [
"breast-fea-vs-adh-architecture",
"breast-fea-bracs-and-expert-definition"
]
},
{
"q": "What separates atypical ductal hyperplasia from low-grade DCIS?",
"expect": [
"breast-adh-vs-dcis-libre-table",
"breast-adh-vs-dcis-size-rules-disagree",
"breast-adh-vs-dcis-same-biology"
]
},
{
"q": "Do different sources agree on the 2 mm rule and the two-duct rule for ADH versus DCIS?",
"expect": [
"breast-adh-vs-dcis-size-rules-disagree"
]
},
{
"q": "Are ADH and low-grade DCIS biologically different?",
"expect": [
"breast-adh-vs-dcis-same-biology",
"breast-dcis-low-grade-vs-high-grade-pathway"
]
},
{
"q": "What do lumina and cell spacing look like in ADH versus DCIS?",
"expect": [
"breast-adh-vs-dcis-libre-table"
]
},
{
"q": "How is nuclear grade of DCIS judged against red blood cells?",
"expect": [
"breast-dcis-libre-features-grading"
]
},
{
"q": "What are the architectural subtypes of DCIS?",
"expect": [
"breast-dcis-subtypes-architecture",
"breast-dcis-bracs-definition"
]
},
{
"q": "Is DCIS grading reproducible between pathologists?",
"expect": [
"breast-dcis-grading-variability"
]
},
{
"q": "Do low-grade and high-grade DCIS share a pathway?",
"expect": [
"breast-dcis-low-grade-vs-high-grade-pathway"
]
},
{
"q": "What H&E evidence establishes invasion in breast carcinoma?",
"expect": [
"breast-ic-libre-invasion-criteria",
"breast-ic-bracs-definition"
]
},
{
"q": "What is invasive carcinoma of no special type?",
"expect": [
"breast-ic-wikipedia-nst",
"breast-ic-libre-invasion-criteria"
]
},
{
"q": "How is invasive breast carcinoma graded?",
"expect": [
"breast-ic-libre-invasion-criteria"
]
},
{
"q": "What does loss of the myoepithelial layer indicate?",
"expect": [
"breast-ic-bracs-definition",
"breast-dcis-vs-ic-myoepithelium"
]
},
{
"q": "How do I tell DCIS from invasive carcinoma?",
"expect": [
"breast-dcis-vs-ic-myoepithelium",
"breast-dcis-vs-ic-he-stroma",
"breast-dcis-vs-ic-confined-to-basement-membrane"
]
},
{
"q": "Which stains show myoepithelial cells around a duct and what do they show in invasive cancer?",
"expect": [
"breast-dcis-vs-ic-myoepithelium",
"breast-n-myoepithelium-key"
]
},
{
"q": "Is DCIS confined by the basement membrane?",
"expect": [
"breast-dcis-vs-ic-confined-to-basement-membrane",
"breast-dcis-bracs-definition"
]
},
{
"q": "What stromal pattern signals invasion beyond in situ disease?",
"expect": [
"breast-dcis-vs-ic-he-stroma",
"breast-ic-libre-invasion-criteria"
]
},
{
"q": "How do I distinguish pathological benign breast tissue from normal breast tissue?",
"expect": [
"breast-n-vs-pb-ratio-and-glands",
"breast-n-bracs-paper-tissue"
]
},
{
"q": "Do dilated glands with two cell layers imply pathological benign rather than normal?",
"expect": [
"breast-n-vs-pb-ratio-and-glands",
"breast-pb-fibrocystic-libre"
]
},
{
"q": "Which BRACS class is the catch-all for benign changes that are neither UDH nor FEA nor ADH?",
"expect": [
"breast-pb-bracs-composition"
]
},
{
"q": "Is fibrocystic change normal or pathological?",
"expect": [
"breast-n-vs-pb-ratio-and-glands",
"breast-pb-fibrocystic-libre"
]
},
{
"q": "Which fine classes belong to the benign, atypical and malignant coarse groups of BRACS?",
"expect": [
"breast-coarse-groups-bracs"
]
}
],
"ebr-coarse30": [
{
"q": "fried egg cells chicken wire capillaries",
"expect": [
"cns-oligodendroglioma-histology"
]
},
{
"q": "necrosis microvascular proliferation glioblastoma",
"expect": [
"cns-gbm-histology",
"cns-astrocytoma-idh-grading"
]
},
{
"q": "EGFR amplification TERT promoter chromosome 7 gain 10 loss",
"expect": [
"cns-gbm-definition"
]
},
{
"q": "what happened to the names anaplastic astrocytoma and glioblastoma IDH-mutant",
"expect": [
"cns-legacy-names",
"cns-who5-overview"
]
},
{
"q": "meningioma subtype grades atypical anaplastic chordoid",
"expect": [
"cns-meningioma-grading"
]
},
{
"q": "ATRX loss p53 overexpression IDH1 R132H",
"expect": [
"cns-astrocytoma-idh-ihc"
]
},
{
"q": "circumscribed glioma grade 1 KIAA1549 BRAF",
"expect": [
"cns-pilocytic"
]
},
{
"q": "ependymoma classification by location ZFTA PFA",
"expect": [
"cns-ependymoma"
]
},
{
"q": "medulloblastoma WNT SHH molecular groups",
"expect": [
"cns-medulloblastoma"
]
},
{
"q": "1p/19q codeletion oligodendroglioma grade 3",
"expect": [
"cns-oligodendroglioma-molecular-grading",
"cns-oligodendroglioma-histology"
]
},
{
"q": "Cerebellar tumour of vacuolated stromal cells in a rich capillary network with reticulin",
"expect": [
"cns-haemangioblastoma-histology-case",
"cns-haemangioblastoma-clear-cell-vascular",
"cns-haemangioblastoma-libre-profile"
]
},
{
"q": "How to tell haemangioblastoma from metastatic clear cell renal carcinoma",
"expect": [
"cns-haemangioblastoma-vs-metastatic-rcc-lineage",
"cns-haemangioblastoma-libre-profile"
]
},
{
"q": "Which stain is positive in haemangioblastoma but not in renal cell carcinoma metastasis",
"expect": [
"cns-haemangioblastoma-vs-metastatic-rcc-lineage",
"cns-haemangioblastoma-libre-profile"
]
},
{
"q": "Vascular channels lined by benign endothelium with red blood cells in the brain",
"expect": [
"cns-haemangioma-libre-histology",
"cns-haemangioma-cavernous-venous-malformation"
]
},
{
"q": "Cavernous haemangioma is a venous malformation with back to back dilated channels",
"expect": [
"cns-haemangioma-cavernous-venous-malformation"
]
},
{
"q": "Vessel rich lesion versus angiomatous meningioma: what separates a vascular malformation",
"expect": [
"cns-haemangioma-vs-angiomatous-meningioma",
"cns-angiomatous-libre-histology"
]
},
{
"q": "Why is haemangiopericytoma now called solitary fibrous tumour and what fusion defines it",
"expect": [
"cns-haemangiopericytoma-naming-grading"
]
},
{
"q": "Staghorn vessels and patternless spindle cell growth with hyalinised collagen",
"expect": [
"cns-haemangiopericytoma-histology",
"cns-haemangiopericytoma-libre-sft"
]
},
{
"q": "Dural spindle cell tumour: solitary fibrous tumour versus fibrous meningioma on stains and pseudoinclusions",
"expect": [
"cns-haemangiopericytoma-vs-meningioma"
]
},
{
"q": "Intracranial mass made of mature fat cells without atypia",
"expect": [
"cns-lipoma-histology",
"cns-lipoma-vs-normal-fat"
]
},
{
"q": "Lipoma versus liposarcoma and normal fat",
"expect": [
"cns-lipoma-vs-normal-fat"
]
},
{
"q": "Cerebellopontine angle lipoma mistaken for hamartoma",
"expect": [
"cns-lipoma-histology"
]
},
{
"q": "Wet keratin stellate reticulum and palisading basal cells in a sellar cystic tumour",
"expect": [
"cns-acp-histology",
"cns-acp-libre-profile"
]
},
{
"q": "Adamantinomatous versus papillary craniopharyngioma histology",
"expect": [
"cns-acp-vs-papillary"
]
},
{
"q": "Craniopharyngioma with CTNNB1 mutation and calcifications",
"expect": [
"cns-acp-libre-profile"
]
},
{
"q": "Reticulin stain to tell pituitary adenoma from normal anterior pituitary",
"expect": [
"cns-pituitary-adenoma-vs-normal-and-metastasis",
"cns-pituitary-adenoma-libre-profile"
]
},
{
"q": "Pituitary adenoma versus metastasis mitoses and pleomorphism",
"expect": [
"cns-pituitary-adenoma-vs-normal-and-metastasis"
]
},
{
"q": "Why pituitary adenoma is now called PitNET and how it is typed",
"expect": [
"cns-pituitary-adenoma-libre-profile"
]
},
{
"q": "Antoni A and Antoni B areas with Verocay bodies",
"expect": [
"cns-schwannoma-libre-histology",
"cns-schwannoma-case-histology"
]
},
{
"q": "Schwannoma versus meningioma thick walled hyalinised vessels",
"expect": [
"cns-schwannoma-libre-histology"
]
},
{
"q": "Spindle cell tumour S100 and SOX10 positive with EMA negative",
"expect": [
"cns-schwannoma-case-histology"
]
},
{
"q": "Well demarcated brain lesion without cytoplasmic processes and with malignant nuclear atypia",
"expect": [
"cns-metastasis-libre-histology",
"cns-metastasis-vs-primary-tumour"
]
},
{
"q": "How to separate a glial tumour from a metastatic carcinoma at high power",
"expect": [
"cns-metastasis-vs-primary-tumour",
"cns-metastasis-libre-histology"
]
},
{
"q": "TTF-1 CK7 CDX2 PAX8 lineage stains for brain metastasis",
"expect": [
"cns-metastasis-lineage-stains"
]
},
{
"q": "Periventricular large B cell lymphoma with perivascular clustering and CD20",
"expect": [
"cns-cnsdlbcl-libre-histology",
"cns-cnsdlbcl-vs-glioblastoma"
]
},
{
"q": "Primary CNS lymphoma versus glioblastoma angiotropism versus necrosis and microvascular proliferation",
"expect": [
"cns-cnsdlbcl-vs-glioblastoma"
]
},
{
"q": "Lymphoma versus tumefactive demyelination foamy macrophages and Creutzfeldt-Peters cells",
"expect": [
"cns-cnsdlbcl-vs-demyelination"
]
},
{
"q": "Reniform nuclei with grooves foamy cytoplasm and eosinophils",
"expect": [
"cns-lch-libre-histology",
"cns-lch-hypothalamic-cytology"
]
},
{
"q": "CD1a and langerin positive histiocytes in the suprasellar region",
"expect": [
"cns-lch-hypothalamic-cytology"
]
},
{
"q": "Differential diagnosis of pituitary stalk and hypothalamic lesions histiocytosis",
"expect": [
"cns-lch-sellar-differential"
]
},
{
"q": "Syncytial meningioma with nuclear pseudoinclusions and AKT1 mutation",
"expect": [
"cns-meningothelial-libre-histology",
"cns-meningioma-classic-histology"
]
},
{
"q": "Meningothelial meningioma lobules separated by thin collagenous septa",
"expect": [
"cns-meningothelial-case-histology"
]
},
{
"q": "Whorls psammoma bodies and nuclear pseudoinclusions in meningioma",
"expect": [
"cns-meningioma-classic-histology"
]
},
{
"q": "Meningioma of parallel spindle cell bundles lacking whorls",
"expect": [
"cns-fibrous-libre-histology",
"cns-fibrous-vs-transitional-histology"
]
},
{
"q": "Fibrous versus transitional meningioma collagenous stroma and psammoma bodies",
"expect": [
"cns-fibrous-vs-transitional-histology"
]
},
{
"q": "Fibrous meningioma versus solitary fibrous tumour by EMA and STAT6",
"expect": [
"cns-haemangiopericytoma-vs-meningioma"
]
},
{
"q": "Mixed meningothelial and fibrous meningioma with whorls and psammoma bodies",
"expect": [
"cns-transitional-libre-histology",
"cns-fibrous-vs-transitional-histology"
]
},
{
"q": "Lobular and fascicular growth together in one meningioma",
"expect": [
"cns-transitional-libre-histology"
]
},
{
"q": "Transitional component of a dumbbell meningioma histology",
"expect": [
"cns-fibrous-vs-transitional-histology"
]
},
{
"q": "Meningioma in which vessels exceed half of the tumour volume",
"expect": [
"cns-angiomatous-histology",
"cns-angiomatous-libre-histology"
]
},
{
"q": "Angiomatous meningioma bleeding risk and low Ki-67",
"expect": [
"cns-angiomatous-histology"
]
},
{
"q": "Cystic angiomatous meningioma mimicking haemangioblastoma",
"expect": [
"cns-angiomatous-cystic-mimics-haemangioblastoma",
"cns-angiomatous-libre-histology"
]
},
{
"q": "Pseudopsammoma bodies PAS positive hyaline inclusions in meningioma",
"expect": [
"cns-secretory-histology",
"cns-secretory-libre-differential"
]
},
{
"q": "Secretory meningioma KLF4 and TRAF7 mutations with CEA positive inclusions",
"expect": [
"cns-secretory-libre-differential"
]
},
{
"q": "Secretory meningioma versus metastatic mucinous adenocarcinoma",
"expect": [
"cns-secretory-libre-differential"
]
},
{
"q": "Criteria for atypical meningioma mitoses brain invasion sheeting",
"expect": [
"cns-atypical-vs-classic-criteria",
"cns-atypical-sellar-histology"
]
},
{
"q": "Atypical meningioma small cell change and loss of lobular architecture",
"expect": [
"cns-atypical-sellar-histology"
]
},
{
"q": "What separates grade 2 from grade 1 meningioma",
"expect": [
"cns-atypical-vs-classic-criteria"
]
},
{
"q": "Anaplastic meningioma 20 mitoses per 10 high power fields carcinoma-like",
"expect": [
"cns-anaplastic-vs-atypical-criteria",
"cns-anaplastic-meningioma-case-criteria"
]
},
{
"q": "Anaplastic versus atypical meningioma mitotic threshold",
"expect": [
"cns-anaplastic-vs-atypical-criteria"
]
},
{
"q": "TERT promoter mutation or CDKN2A deletion grade 3 meningioma in a child",
"expect": [
"cns-anaplastic-meningioma-case-criteria"
]
},
{
"q": "Perivascular pseudorosettes and true ependymal rosettes in a sharply demarcated tumour",
"expect": [
"cns-ependymoma-histology"
]
},
{
"q": "Ependymoma versus glioblastoma border circumscribed or invasive",
"expect": [
"cns-ependymoma-libre-differential"
]
},
{
"q": "Clear cell ependymoma mimicking oligodendroglioma ZFTA",
"expect": [
"cns-ependymoma-clear-cell-vs-oligodendroglioma"
]
},
{
"q": "Grade 3 ependymoma criteria mitoses microvascular proliferation",
"expect": [
"cns-anaplastic-ependymoma-grading",
"cns-anaplastic-ependymoma-histology"
]
},
{
"q": "Anaplastic ependymoma legacy name and grade",
"expect": [
"cns-anaplastic-ependymoma-grading"
]
},
{
"q": "Spinal ependymoma with nuclear pleomorphism and MYCN expression",
"expect": [
"cns-anaplastic-ependymoma-histology"
]
},
{
"q": "Biphasic tumour with Rosenthal fibres and eosinophilic granular bodies",
"expect": [
"cns-pilocytic-histology-review",
"cns-pilocytic-libre-histology"
]
},
{
"q": "Piloid gliosis around craniopharyngioma mimicking pilocytic astrocytoma",
"expect": [
"cns-pilocytic-differential-piloid-gliosis"
]
},
{
"q": "Pilocytic astrocytoma versus oligodendroglioma circumscribed and BRAF",
"expect": [
"cns-pilocytic-vs-oligodendroglioma"
]
},
{
"q": "Dysplastic neurons together with neoplastic glia in a temporal lobe epilepsy tumour",
"expect": [
"cns-ganglioglioma-histology-review",
"cns-ganglioglioma-libre-histology"
]
},
{
"q": "Ganglioglioma versus DNET and pilocytic astrocytoma",
"expect": [
"cns-ganglioglioma-vs-dnet-and-pilocytic"
]
},
{
"q": "Ganglioglioma lymphocytic cuffing and perimembranous Nissl",
"expect": [
"cns-ganglioglioma-libre-histology"
]
},
{
"q": "Biphasic glioblastoma with reticulin rich GFAP negative sarcomatous areas",
"expect": [
"cns-gliosarcoma-biphasic-histology",
"cns-gliosarcoma-vs-glioblastoma"
]
},
{
"q": "Sarcomatous components in gliosarcoma cartilage bone muscle",
"expect": [
"cns-gliosarcoma-sarcomatous-types"
]
},
{
"q": "Gliosarcoma versus glioblastoma distinction",
"expect": [
"cns-gliosarcoma-vs-glioblastoma"
]
},
{
"q": "Anaplastic astrocytoma with pleomorphism mitoses but no necrosis or vascular proliferation",
"expect": [
"cns-anaplastic-astrocytoma-wt-histology",
"cns-anaplastic-astrocytoma-wt-vs-gbm"
]
},
{
"q": "Anaplastic astrocytoma versus glioblastoma histological line",
"expect": [
"cns-anaplastic-astrocytoma-wt-vs-gbm"
]
},
{
"q": "IDH-wildtype astrocytoma underdiagnosed glioblastoma",
"expect": [
"cns-anaplastic-astrocytoma-wt-histology"
]
},
{
"q": "Small round cell cerebellar tumour with Homer-Wright rosettes",
"expect": [
"cns-medulloblastoma-histology"
]
},
{
"q": "Group 3 and group 4 medulloblastoma histology and MYC",
"expect": [
"cns-medulloblastoma-groups-and-histology"
]
},
{
"q": "Medulloblastoma versus ATRT ETMR and other small round cell tumours",
"expect": [
"cns-medulloblastoma-small-round-cell-differential"
]
},
{
"q": "Why can a tumour that looks like grade 2 astrocytoma on H&E be grade 4",
"expect": [
"cns-astrocytoma-idh-mutant-grading-review",
"cns-gbm-histological-vs-molecular"
]
},
{
"q": "Molecular glioblastoma without necrosis or microvascular proliferation TERT EGFR",
"expect": [
"cns-gbm-histological-vs-molecular",
"cns-aa-idh-wt-histologic-grade-outcome"
]
},
{
"q": "IDH wildtype grade 2 or 3 astrocytoma outcome compared with glioblastoma",
"expect": [
"cns-aa-idh-wt-histologic-grade-outcome"
]
},
{
"q": "Does medulloblastoma histology determine the molecular group",
"expect": [
"cns-medulloblastoma-histology-vs-molecular-group"
]
},
{
"q": "Langerhans cell nuclear grooves eosinophils and overlapping histiocytic lesions",
"expect": [
"cns-lch-he-limitation"
]
},
{
"q": "Can a metastasis infiltrate brain beyond a well-demarcated border",
"expect": [
"cns-metastasis-infiltration-caveat"
]
},
{
"q": "Perinuclear halo and chicken wire vessels in a tumour that is not oligodendroglioma",
"expect": [
"cns-oligodendroglioma-like-pitfall"
]
}
],
"bracs-coarse": [
{
"q": "Which fine classes belong to the benign, atypical and malignant coarse groups of BRACS?",
"expect": [
"breast-coarse-groups-bracs"
]
},
{
"q": "How many slides are in each BRACS coarse group?",
"expect": [
"breast-coarse-groups-bracs"
]
},
{
"q": "Why are atypical lesions hard to classify on needle biopsy?",
"expect": [
"breast-coarse-groups-bracs",
"breast-fea-vs-adh-expert-disagreement"
]
},
{
"q": "What separates atypical from malignant lesions in the ductal spectrum?",
"expect": [
"breast-adh-vs-dcis-libre-table",
"breast-adh-vs-dcis-same-biology"
]
}
]
}
|